Matching by Monotonic Tone Mapping.

Science.gov (United States)

Kovacs, Gyorgy

2018-06-01

In this paper, a novel dissimilarity measure called Matching by Monotonic Tone Mapping (MMTM) is proposed. The MMTM technique allows matching under non-linear monotonic tone mappings and can be computed efficiently when the tone mappings are approximated by piecewise constant or piecewise linear functions. The proposed method is evaluated in various template matching scenarios involving simulated and real images, and compared to other measures developed to be invariant to monotonic intensity transformations. The results show that the MMTM technique is a highly competitive alternative of conventional measures in problems where possible tone mappings are close to monotonic.

Monotonicity of the von Neumann entropy expressed as a function of R\\'enyi entropies

OpenAIRE

Fannes, Mark

2013-01-01

The von Neumann entropy of a density matrix of dimension d, expressed in terms of the first d-1 integer order R\\'enyi entropies, is monotonically increasing in R\\'enyi entropies of even order and decreasing in those of odd order.

Multipartite classical and quantum secrecy monotones

International Nuclear Information System (INIS)

Cerf, N.J.; Massar, S.; Schneider, S.

2002-01-01

In order to study multipartite quantum cryptography, we introduce quantities which vanish on product probability distributions, and which can only decrease if the parties carry out local operations or public classical communication. These 'secrecy monotones' therefore measure how much secret correlation is shared by the parties. In the bipartite case we show that the mutual information is a secrecy monotone. In the multipartite case we describe two different generalizations of the mutual information, both of which are secrecy monotones. The existence of two distinct secrecy monotones allows us to show that in multipartite quantum cryptography the parties must make irreversible choices about which multipartite correlations they want to obtain. Secrecy monotones can be extended to the quantum domain and are then defined on density matrices. We illustrate this generalization by considering tripartite quantum cryptography based on the Greenberger-Horne-Zeilinger state. We show that before carrying out measurements on the state, the parties must make an irreversible decision about what probability distribution they want to obtain

An electronic implementation for Liao's chaotic delayed neuron model with non-monotonous activation function

International Nuclear Information System (INIS)

Duan Shukai; Liao Xiaofeng

2007-01-01

A new chaotic delayed neuron model with non-monotonously increasing transfer function, called as chaotic Liao's delayed neuron model, was recently reported and analyzed. An electronic implementation of this model is described in detail. At the same time, some methods in circuit design, especially for circuit with time delayed unit and non-monotonously increasing activation unit, are also considered carefully. We find that the dynamical behaviors of the designed circuits are closely similar to the results predicted by numerical experiments

Edit Distance to Monotonicity in Sliding Windows

DEFF Research Database (Denmark)

Chan, Ho-Leung; Lam, Tak-Wah; Lee, Lap Kei

2011-01-01

Given a stream of items each associated with a numerical value, its edit distance to monotonicity is the minimum number of items to remove so that the remaining items are non-decreasing with respect to the numerical value. The space complexity of estimating the edit distance to monotonicity of a ...

Monotone Approximations of Minimum and Maximum Functions and Multi-objective Problems

International Nuclear Information System (INIS)

Stipanović, Dušan M.; Tomlin, Claire J.; Leitmann, George

2012-01-01

In this paper the problem of accomplishing multiple objectives by a number of agents represented as dynamic systems is considered. Each agent is assumed to have a goal which is to accomplish one or more objectives where each objective is mathematically formulated using an appropriate objective function. Sufficient conditions for accomplishing objectives are derived using particular convergent approximations of minimum and maximum functions depending on the formulation of the goals and objectives. These approximations are differentiable functions and they monotonically converge to the corresponding minimum or maximum function. Finally, an illustrative pursuit-evasion game example with two evaders and two pursuers is provided.

Monotone Approximations of Minimum and Maximum Functions and Multi-objective Problems

Energy Technology Data Exchange (ETDEWEB)

Stipanovic, Dusan M., E-mail: dusan@illinois.edu [University of Illinois at Urbana-Champaign, Coordinated Science Laboratory, Department of Industrial and Enterprise Systems Engineering (United States); Tomlin, Claire J., E-mail: tomlin@eecs.berkeley.edu [University of California at Berkeley, Department of Electrical Engineering and Computer Science (United States); Leitmann, George, E-mail: gleit@berkeley.edu [University of California at Berkeley, College of Engineering (United States)

2012-12-15

In this paper the problem of accomplishing multiple objectives by a number of agents represented as dynamic systems is considered. Each agent is assumed to have a goal which is to accomplish one or more objectives where each objective is mathematically formulated using an appropriate objective function. Sufficient conditions for accomplishing objectives are derived using particular convergent approximations of minimum and maximum functions depending on the formulation of the goals and objectives. These approximations are differentiable functions and they monotonically converge to the corresponding minimum or maximum function. Finally, an illustrative pursuit-evasion game example with two evaders and two pursuers is provided.

A note on monotone solutions for a nonconvex second-order functional differential inclusion

Directory of Open Access Journals (Sweden)

Aurelian Cernea

2011-12-01

Full Text Available The existence of monotone solutions for a second-order functional differential inclusion with Carath\\'{e}odory perturbation is obtained in the case when the multifunction that define the inclusion is upper semicontinuous compact valued and contained in the Fr\\'{e}chet subdifferential of a $\\phi $-convex function of order two.

A non-parametric test for partial monotonicity in multiple regression

NARCIS (Netherlands)

van Beek, M.; Daniëls, H.A.M.

Partial positive (negative) monotonicity in a dataset is the property that an increase in an independent variable, ceteris paribus, generates an increase (decrease) in the dependent variable. A test for partial monotonicity in datasets could (1) increase model performance if monotonicity may be

Totally Optimal Decision Trees for Monotone Boolean Functions with at Most Five Variables

KAUST Repository

Chikalov, Igor; Hussain, Shahid; Moshkov, Mikhail

2013-01-01

In this paper, we present the empirical results for relationships between time (depth) and space (number of nodes) complexity of decision trees computing monotone Boolean functions, with at most five variables. We use Dagger (a tool for optimization

A Survey on Operator Monotonicity, Operator Convexity, and Operator Means

Directory of Open Access Journals (Sweden)

Pattrawut Chansangiam

2015-01-01

Full Text Available This paper is an expository devoted to an important class of real-valued functions introduced by Löwner, namely, operator monotone functions. This concept is closely related to operator convex/concave functions. Various characterizations for such functions are given from the viewpoint of differential analysis in terms of matrix of divided differences. From the viewpoint of operator inequalities, various characterizations and the relationship between operator monotonicity and operator convexity are given by Hansen and Pedersen. In the viewpoint of measure theory, operator monotone functions on the nonnegative reals admit meaningful integral representations with respect to Borel measures on the unit interval. Furthermore, Kubo-Ando theory asserts the correspondence between operator monotone functions and operator means.

Testing Manifest Monotonicity Using Order-Constrained Statistical Inference

Science.gov (United States)

Tijmstra, Jesper; Hessen, David J.; van der Heijden, Peter G. M.; Sijtsma, Klaas

2013-01-01

Most dichotomous item response models share the assumption of latent monotonicity, which states that the probability of a positive response to an item is a nondecreasing function of a latent variable intended to be measured. Latent monotonicity cannot be evaluated directly, but it implies manifest monotonicity across a variety of observed scores,…

Multistability of memristive Cohen-Grossberg neural networks with non-monotonic piecewise linear activation functions and time-varying delays.

Science.gov (United States)

Nie, Xiaobing; Zheng, Wei Xing; Cao, Jinde

2015-11-01

The problem of coexistence and dynamical behaviors of multiple equilibrium points is addressed for a class of memristive Cohen-Grossberg neural networks with non-monotonic piecewise linear activation functions and time-varying delays. By virtue of the fixed point theorem, nonsmooth analysis theory and other analytical tools, some sufficient conditions are established to guarantee that such n-dimensional memristive Cohen-Grossberg neural networks can have 5(n) equilibrium points, among which 3(n) equilibrium points are locally exponentially stable. It is shown that greater storage capacity can be achieved by neural networks with the non-monotonic activation functions introduced herein than the ones with Mexican-hat-type activation function. In addition, unlike most existing multistability results of neural networks with monotonic activation functions, those obtained 3(n) locally stable equilibrium points are located both in saturated regions and unsaturated regions. The theoretical findings are verified by an illustrative example with computer simulations. Copyright © 2015 Elsevier Ltd. All rights reserved.

Monotonism.

Science.gov (United States)

Franklin, Elda

1981-01-01

Reviews studies on the etiology of monotonism, the monotone being that type of uncertain or inaccurate singer who cannot vocally match pitches and who has trouble accurately reproducing even a familiar song. Neurological factors (amusia, right brain abnormalities), age, and sex differences are considered. (Author/SJL)

Complete Monotonicity of a Difference Between the Exponential and Trigamma Functions and Properties Related to a Modified Bessel Function

DEFF Research Database (Denmark)

Qi, Feng; Berg, Christian

2013-01-01

In the paper, the authors find necessary and sufficient conditions for a difference between the exponential function αeβ/t, α, β > 0, and the trigamma function ψ (t) to be completely monotonic on (0,∞). While proving the complete onotonicity, the authors discover some properties related to the fi...

Reduction theorems for weighted integral inequalities on the cone of monotone functions

Czech Academy of Sciences Publication Activity Database

Gogatishvili, Amiran; Stepanov, V.D.

2013-01-01

Roč. 68, č. 4 (2013), s. 597-664 ISSN 0036-0279 R&D Projects: GA ČR GA201/08/0383; GA ČR GA13-14743S Institutional support: RVO:67985840 Keywords : weighted Lebesgue space * cone of monotone functions * duality principle Subject RIV: BA - General Mathematics Impact factor: 1.357, year: 2013 http://iopscience.iop.org/0036-0279/68/4/597

An electronic implementation for Liao's chaotic delayed neuron model with non-monotonous activation function

Energy Technology Data Exchange (ETDEWEB)

Duan Shukai [Department of Computer Science and Engineering, Chongqing University, Chongqing 400044 (China); School of Electronic and Information Engineering, Southwest University, Chongqing 400715 (China)], E-mail: duansk@swu.edu.cn; Liao Xiaofeng [Department of Computer Science and Engineering, Chongqing University, Chongqing 400044 (China)], E-mail: xfliao@cqu.edu.cn

2007-09-10

A new chaotic delayed neuron model with non-monotonously increasing transfer function, called as chaotic Liao's delayed neuron model, was recently reported and analyzed. An electronic implementation of this model is described in detail. At the same time, some methods in circuit design, especially for circuit with time delayed unit and non-monotonously increasing activation unit, are also considered carefully. We find that the dynamical behaviors of the designed circuits are closely similar to the results predicted by numerical experiments.

Moduli and Characteristics of Monotonicity in Some Banach Lattices

Directory of Open Access Journals (Sweden)

Miroslav Krbec

2010-01-01

Full Text Available First the characteristic of monotonicity of any Banach lattice X is expressed in terms of the left limit of the modulus of monotonicity of X at the point 1. It is also shown that for Köthe spaces the classical characteristic of monotonicity is the same as the characteristic of monotonicity corresponding to another modulus of monotonicity δ^m,E. The characteristic of monotonicity of Orlicz function spaces and Orlicz sequence spaces equipped with the Luxemburg norm are calculated. In the first case the characteristic is expressed in terms of the generating Orlicz function only, but in the sequence case the formula is not so direct. Three examples show why in the sequence case so direct formula is rather impossible. Some other auxiliary and complemented results are also presented. By the results of Betiuk-Pilarska and Prus (2008 which establish that Banach lattices X with ε0,m(X<1 and weak orthogonality property have the weak fixed point property, our results are related to the fixed point theory (Kirk and Sims (2001.

Specific non-monotonous interactions increase persistence of ecological networks.

Science.gov (United States)

Yan, Chuan; Zhang, Zhibin

2014-03-22

The relationship between stability and biodiversity has long been debated in ecology due to opposing empirical observations and theoretical predictions. Species interaction strength is often assumed to be monotonically related to population density, but the effects on stability of ecological networks of non-monotonous interactions that change signs have not been investigated previously. We demonstrate that for four kinds of non-monotonous interactions, shifting signs to negative or neutral interactions at high population density increases persistence (a measure of stability) of ecological networks, while for the other two kinds of non-monotonous interactions shifting signs to positive interactions at high population density decreases persistence of networks. Our results reveal a novel mechanism of network stabilization caused by specific non-monotonous interaction types through either increasing stable equilibrium points or reducing unstable equilibrium points (or both). These specific non-monotonous interactions may be important in maintaining stable and complex ecological networks, as well as other networks such as genes, neurons, the internet and human societies.

Non-monotonic relationships between emotional arousal and memory for color and location.

Science.gov (United States)

Boywitt, C Dennis

2015-01-01

Recent research points to the decreased diagnostic value of subjective retrieval experience for memory accuracy for emotional stimuli. While for neutral stimuli rich recollective experiences are associated with better context memory than merely familiar memories this association appears questionable for emotional stimuli. The present research tested the implicit assumption that the effect of emotional arousal on memory is monotonic, that is, steadily increasing (or decreasing) with increasing arousal. In two experiments emotional arousal was manipulated in three steps using emotional pictures and subjective retrieval experience as well as context memory were assessed. The results show an inverted U-shape relationship between arousal and recognition memory but for context memory and retrieval experience the relationship was more complex. For frame colour, context memory decreased linearly while for spatial location it followed the inverted U-shape function. The complex, non-monotonic relationships between arousal and memory are discussed as possible explanations for earlier divergent findings.

Use of empirical likelihood to calibrate auxiliary information in partly linear monotone regression models.

Science.gov (United States)

Chen, Baojiang; Qin, Jing

2014-05-10

In statistical analysis, a regression model is needed if one is interested in finding the relationship between a response variable and covariates. When the response depends on the covariate, then it may also depend on the function of this covariate. If one has no knowledge of this functional form but expect for monotonic increasing or decreasing, then the isotonic regression model is preferable. Estimation of parameters for isotonic regression models is based on the pool-adjacent-violators algorithm (PAVA), where the monotonicity constraints are built in. With missing data, people often employ the augmented estimating method to improve estimation efficiency by incorporating auxiliary information through a working regression model. However, under the framework of the isotonic regression model, the PAVA does not work as the monotonicity constraints are violated. In this paper, we develop an empirical likelihood-based method for isotonic regression model to incorporate the auxiliary information. Because the monotonicity constraints still hold, the PAVA can be used for parameter estimation. Simulation studies demonstrate that the proposed method can yield more efficient estimates, and in some situations, the efficiency improvement is substantial. We apply this method to a dementia study. Copyright © 2013 John Wiley & Sons, Ltd.

Dynamical zeta functions for piecewise monotone maps of the interval

CERN Document Server

Ruelle, David

2004-01-01

Consider a space M, a map f:M\\to M, and a function g:M \\to {\\mathbb C}. The formal power series \\zeta (z) = \\exp \\sum ^\\infty _{m=1} \\frac {z^m}{m} \\sum _{x \\in \\mathrm {Fix}\\,f^m} \\prod ^{m-1}_{k=0} g (f^kx) yields an example of a dynamical zeta function. Such functions have unexpected analytic properties and interesting relations to the theory of dynamical systems, statistical mechanics, and the spectral theory of certain operators (transfer operators). The first part of this monograph presents a general introduction to this subject. The second part is a detailed study of the zeta functions associated with piecewise monotone maps of the interval [0,1]. In particular, Ruelle gives a proof of a generalized form of the Baladi-Keller theorem relating the poles of \\zeta (z) and the eigenvalues of the transfer operator. He also proves a theorem expressing the largest eigenvalue of the transfer operator in terms of the ergodic properties of (M,f,g).

Necessary and sufficient conditions for a class of functions and their reciprocals to be logarithmically completely monotonic

OpenAIRE

Lv Yu-Pei; Sun Tian-Chuan; Chu Yu-Ming

2011-01-01

Abstract We prove that the function F α,β (x) = x α Γ β (x)/Γ(βx) is strictly logarithmically completely monotonic on (0, ∞) if and only if (α, β) ∈ {(α, β) : β > 0, β ≥ 2α + 1, β ≥ α + 1}{(α, β) : α = 0, β = 1} and that [F α,β (x)]-1 is strictly logarithmically completely monotonic on (0, ∞) if and only if (α, β) ∈ {(α, β ...

Testing manifest monotonicity using order-constrained statistical inference

NARCIS (Netherlands)

Tijmstra, J.; Hessen, D.J.; van der Heijden, P.G.M.; Sijtsma, K.

2013-01-01

Most dichotomous item response models share the assumption of latent monotonicity, which states that the probability of a positive response to an item is a nondecreasing function of a latent variable intended to be measured. Latent monotonicity cannot be evaluated directly, but it implies manifest

Unordered Monotonicity.

Science.gov (United States)

Heckman, James J; Pinto, Rodrigo

2018-01-01

This paper defines and analyzes a new monotonicity condition for the identification of counterfactuals and treatment effects in unordered discrete choice models with multiple treatments, heterogenous agents and discrete-valued instruments. Unordered monotonicity implies and is implied by additive separability of choice of treatment equations in terms of observed and unobserved variables. These results follow from properties of binary matrices developed in this paper. We investigate conditions under which unordered monotonicity arises as a consequence of choice behavior. We characterize IV estimators of counterfactuals as solutions to discrete mixture problems.

Monotone piecewise bicubic interpolation

International Nuclear Information System (INIS)

Carlson, R.E.; Fritsch, F.N.

1985-01-01

In a 1980 paper the authors developed a univariate piecewise cubic interpolation algorithm which produces a monotone interpolant to monotone data. This paper is an extension of those results to monotone script C 1 piecewise bicubic interpolation to data on a rectangular mesh. Such an interpolant is determined by the first partial derivatives and first mixed partial (twist) at the mesh points. Necessary and sufficient conditions on these derivatives are derived such that the resulting bicubic polynomial is monotone on a single rectangular element. These conditions are then simplified to a set of sufficient conditions for monotonicity. The latter are translated to a system of linear inequalities, which form the basis for a monotone piecewise bicubic interpolation algorithm. 4 references, 6 figures, 2 tables

Multistability of neural networks with discontinuous non-monotonic piecewise linear activation functions and time-varying delays.

Science.gov (United States)

Nie, Xiaobing; Zheng, Wei Xing

2015-05-01

This paper is concerned with the problem of coexistence and dynamical behaviors of multiple equilibrium points for neural networks with discontinuous non-monotonic piecewise linear activation functions and time-varying delays. The fixed point theorem and other analytical tools are used to develop certain sufficient conditions that ensure that the n-dimensional discontinuous neural networks with time-varying delays can have at least 5(n) equilibrium points, 3(n) of which are locally stable and the others are unstable. The importance of the derived results is that it reveals that the discontinuous neural networks can have greater storage capacity than the continuous ones. Moreover, different from the existing results on multistability of neural networks with discontinuous activation functions, the 3(n) locally stable equilibrium points obtained in this paper are located in not only saturated regions, but also unsaturated regions, due to the non-monotonic structure of discontinuous activation functions. A numerical simulation study is conducted to illustrate and support the derived theoretical results. Copyright © 2015 Elsevier Ltd. All rights reserved.

Monotonicity of social welfare optima

DEFF Research Database (Denmark)

Hougaard, Jens Leth; Østerdal, Lars Peter Raahave

2010-01-01

This paper considers the problem of maximizing social welfare subject to participation constraints. It is shown that for an income allocation method that maximizes a social welfare function there is a monotonic relationship between the incomes allocated to individual agents in a given coalition...

Monotonicity of fitness landscapes and mutation rate control.

Science.gov (United States)

Belavkin, Roman V; Channon, Alastair; Aston, Elizabeth; Aston, John; Krašovec, Rok; Knight, Christopher G

2016-12-01

A common view in evolutionary biology is that mutation rates are minimised. However, studies in combinatorial optimisation and search have shown a clear advantage of using variable mutation rates as a control parameter to optimise the performance of evolutionary algorithms. Much biological theory in this area is based on Ronald Fisher's work, who used Euclidean geometry to study the relation between mutation size and expected fitness of the offspring in infinite phenotypic spaces. Here we reconsider this theory based on the alternative geometry of discrete and finite spaces of DNA sequences. First, we consider the geometric case of fitness being isomorphic to distance from an optimum, and show how problems of optimal mutation rate control can be solved exactly or approximately depending on additional constraints of the problem. Then we consider the general case of fitness communicating only partial information about the distance. We define weak monotonicity of fitness landscapes and prove that this property holds in all landscapes that are continuous and open at the optimum. This theoretical result motivates our hypothesis that optimal mutation rate functions in such landscapes will increase when fitness decreases in some neighbourhood of an optimum, resembling the control functions derived in the geometric case. We test this hypothesis experimentally by analysing approximately optimal mutation rate control functions in 115 complete landscapes of binding scores between DNA sequences and transcription factors. Our findings support the hypothesis and find that the increase of mutation rate is more rapid in landscapes that are less monotonic (more rugged). We discuss the relevance of these findings to living organisms.

Non-monotonic piezoresistive behaviour of graphene nanoplatelet (GNP-polymer composite flexible films prepared by solvent casting

Directory of Open Access Journals (Sweden)

S. Makireddi

2017-07-01

Full Text Available Graphene-polymer nanocomposite films show good piezoresistive behaviour and it is reported that the sensitivity increases either with the increased sheet resistance or decreased number density of the graphene fillers. A little is known about this behaviour near the percolation region. In this study, graphene nanoplatelet (GNP/poly (methyl methacrylate (PMMA flexible films are fabricated via solution casting process at varying weight percent of GNP. Electrical and piezoresistive behaviour of these films is studied as a function of GNP concentration. Piezoresistive strain sensitivity of the films is measured by affixing the film to an aluminium specimen which is subjected to monotonic uniaxial tensile load. The change in resistance of the film with strain is monitored using a four probe. An electrical percolation threshold at 3 weight percent of GNP is observed. We report non-monotonic piezoresistive behaviour of these films as a function GNP concentration. We observe an increase in gauge factor (GF with unstrained resistance of the films up to a critical resistance corresponding to percolation threshold. Beyond this limit the GF decreases with unstrained resistance.

Strong Convergence of Monotone Hybrid Method for Maximal Monotone Operators and Hemirelatively Nonexpansive Mappings

Directory of Open Access Journals (Sweden)

Chakkrid Klin-eam

2009-01-01

Full Text Available We prove strong convergence theorems for finding a common element of the zero point set of a maximal monotone operator and the fixed point set of a hemirelatively nonexpansive mapping in a Banach space by using monotone hybrid iteration method. By using these results, we obtain new convergence results for resolvents of maximal monotone operators and hemirelatively nonexpansive mappings in a Banach space.

Ergodic averages for monotone functions using upper and lower dominating processes

DEFF Research Database (Denmark)

Møller, Jesper; Mengersen, Kerrie

We show how the mean of a monotone function (defined on a state space equipped with a partial ordering) can be estimated, using ergodic averages calculated from upper and lower dominating processes of a stationary irreducible Markov chain. In particular, we do not need to simulate the stationary...... Markov chain and we eliminate the problem of whether an appropriate burn-in is determined or not. Moreover, when a central limit theorem applies, we show how confidence intervals for the mean can be estimated by bounding the asymptotic variance of the ergodic average based on the equilibrium chain. Our...... methods are studied in detail for three models using Markov chain Monte Carlo methods and we also discuss various types of other models for which our methods apply....

Ergodic averages for monotone functions using upper and lower dominating processes

DEFF Research Database (Denmark)

Møller, Jesper; Mengersen, Kerrie

2007-01-01

We show how the mean of a monotone function (defined on a state space equipped with a partial ordering) can be estimated, using ergodic averages calculated from upper and lower dominating processes of a stationary irreducible Markov chain. In particular, we do not need to simulate the stationary...... Markov chain and we eliminate the problem of whether an appropriate burn-in is determined or not. Moreover, when a central limit theorem applies, we show how confidence intervals for the mean can be estimated by bounding the asymptotic variance of the ergodic average based on the equilibrium chain. Our...... methods are studied in detail for three models using Markov chain Monte Carlo methods and we also discuss various types of other models for which our methods apply....

The monotonicity and convexity of a function involving digamma one and their applications

OpenAIRE

Yang, Zhen-Hang

2014-01-01

Let $\\mathcal{L}(x,a)$ be defined on $\\left( -1,\\infty \\right) \\times \\left( 4/15,\\infty \\right) $ or $\\left( 0,\\infty \\right) \\times \\left( 1/15,\\infty \\right) $ by the formula% \\begin{equation*} \\mathcal{L}(x,a)=\\tfrac{1}{90a^{2}+2}\\ln \\left( x^{2}+x+\\tfrac{3a+1}{3}% \\right) +\\tfrac{45a^{2}}{90a^{2}+2}\\ln \\left( x^{2}+x+\\allowbreak \\tfrac{% 15a-1}{45a}\\right) . \\end{equation*} We investigate the monotonicity and convexity of the function $x\\rightarrow F_{a}\\left( x\\right) =\\psi \\left( x+1\\r...

Generalized monotone operators in Banach spaces

International Nuclear Information System (INIS)

Nanda, S.

1988-07-01

The concept of F-monotonicity was first introduced by Kato and this generalizes the notion of monotonicity introduced by Minty. The purpose of this paper is to define various types of F-monotonicities and discuss the relationships among them. (author). 6 refs

Solvability conditions of the Cauchy problem for two-dimensional systems of linear functional differential equations with monotone operators

Czech Academy of Sciences Publication Activity Database

Šremr, Jiří

2007-01-01

Roč. 132, č. 3 (2007), s. 263-295 ISSN 0862-7959 R&D Projects: GA ČR GP201/04/P183 Institutional research plan: CEZ:AV0Z10190503 Keywords : system of functional differential equations with monotone operators * initial value problem * unique solvability Subject RIV: BA - General Mathematics

Information flow in layered networks of non-monotonic units

International Nuclear Information System (INIS)

Neves, Fabio Schittler; Schubert, Benno Martim; Erichsen, Rubem Jr

2015-01-01

Layered neural networks are feedforward structures that yield robust parallel and distributed pattern recognition. Even though much attention has been paid to pattern retrieval properties in such systems, many aspects of their dynamics are not yet well characterized or understood. In this work we study, at different temperatures, the memory activity and information flows through layered networks in which the elements are the simplest binary odd non-monotonic function. Our results show that, considering a standard Hebbian learning approach, the network information content has its maximum always at the monotonic limit, even though the maximum memory capacity can be found at non-monotonic values for small enough temperatures. Furthermore, we show that such systems exhibit rich macroscopic dynamics, including not only fixed point solutions of its iterative map, but also cyclic and chaotic attractors that also carry information. (paper)

Information flow in layered networks of non-monotonic units

Science.gov (United States)

Schittler Neves, Fabio; Martim Schubert, Benno; Erichsen, Rubem, Jr.

2015-07-01

Layered neural networks are feedforward structures that yield robust parallel and distributed pattern recognition. Even though much attention has been paid to pattern retrieval properties in such systems, many aspects of their dynamics are not yet well characterized or understood. In this work we study, at different temperatures, the memory activity and information flows through layered networks in which the elements are the simplest binary odd non-monotonic function. Our results show that, considering a standard Hebbian learning approach, the network information content has its maximum always at the monotonic limit, even though the maximum memory capacity can be found at non-monotonic values for small enough temperatures. Furthermore, we show that such systems exhibit rich macroscopic dynamics, including not only fixed point solutions of its iterative map, but also cyclic and chaotic attractors that also carry information.

Optimal Monotone Drawings of Trees

OpenAIRE

He, Dayu; He, Xin

2016-01-01

A monotone drawing of a graph G is a straight-line drawing of G such that, for every pair of vertices u,w in G, there exists abpath P_{uw} in G that is monotone in some direction l_{uw}. (Namely, the order of the orthogonal projections of the vertices of P_{uw} on l_{uw} is the same as the order they appear in P_{uw}.) The problem of finding monotone drawings for trees has been studied in several recent papers. The main focus is to reduce the size of the drawing. Currently, the smallest drawi...

Monotonicity properties of keff with shape change and with nesting

International Nuclear Information System (INIS)

Arzhanov, V.

2002-01-01

It was found that, contrary to expectations based on physical intuition, k eff can both increase and decrease when changing the shape of an initially regular critical system, while preserving its volume. Physical intuition would only allow for a decrease of k eff when the surface/volume ratio increases. The unexpected behaviour of increasing k eff was found through numerical investigation. For a convincing demonstration of the possibility of the non-monotonic behaviour, a simple geometrical proof was constructed. This latter proof, in turn, is based on the assumption that k eff can only increase (or stay constant) in the case of nesting, i.e. when adding extra volume to a system. Since we found no formal proof of the nesting theorem for the general case, we close the paper by a simple formal proof of the monotonic behaviour of k eff by nesting

Studies on the zeros of Bessel functions and methods for their computation: 2. Monotonicity, convexity, concavity, and other properties

Science.gov (United States)

Kerimov, M. K.

2016-07-01

This work continues the study of real zeros of first- and second-kind Bessel functions and Bessel general functions with real variables and orders begun in the first part of this paper (see M.K. Kerimov, Comput. Math. Math. Phys. 54 (9), 1337-1388 (2014)). Some new results concerning such zeros are described and analyzed. Special attention is given to the monotonicity, convexity, and concavity of zeros with respect to their ranks and other parameters.

Monotonicity of the ratio of modified Bessel functions of the first kind with applications.

Science.gov (United States)

Yang, Zhen-Hang; Zheng, Shen-Zhou

2018-01-01

Let [Formula: see text] with [Formula: see text] be the modified Bessel functions of the first kind of order v . In this paper, we prove the monotonicity of the function [Formula: see text] on [Formula: see text] for different values of parameter p with [Formula: see text]. As applications, we deduce some new Simpson-Spector-type inequalities for [Formula: see text] and derive a new type of bounds [Formula: see text] ([Formula: see text]) for [Formula: see text]. In particular, we show that the upper bound [Formula: see text] for [Formula: see text] is the minimum over all upper bounds [Formula: see text], where [Formula: see text] and is not comparable with other sharpest upper bounds. We also find such type of upper bounds for [Formula: see text] with [Formula: see text] and for [Formula: see text] with [Formula: see text].

Characteristic of monotonicity of Orlicz function spaces equipped with the Orlicz norm

Czech Academy of Sciences Publication Activity Database

Foralewski, P.; Hudzik, H.; Kaczmarek, R.; Krbec, Miroslav

2013-01-01

Roč. 53, č. 2 (2013), s. 421-432 ISSN 0373-8299 R&D Projects: GA ČR GAP201/10/1920 Institutional support: RVO:67985840 Keywords : Orlicz space * Köthe space * characteristic of monotonicity Subject RIV: BA - General Mathematics

Sufficient Condition for Monotonicity in Constructing the Distribution Function With Bernoulli Scheme

Directory of Open Access Journals (Sweden)

Vedenyapin Aleksandr Dmitrievich

2015-11-01

Full Text Available This paper is the construction of the distribution function using the Bernoulli scheme, and is also designed to correct some of the mistakes that were made in the article [2]. Namely, a function built in [2] need not be monotonous, and some formulas need to be adjusted. The idea of building as well as in [2], is based on the model of Cox-Ross-Rubinstein "binary market". The essence of the model was to divide time into N steps, and assuming that the price of an asset at each step can move either up to a certain value with probability p, or down also by some certain value with probability q = 1 - p. Prices in step N can take only a finite number of values. "Success" or "failure" was the changing price for some fixed value in the model of Cox-Ross-Rubinstein. Here as a "success" or "failure" at every step we consider the affiliation of changing the index value to the section [r, S] either to the interval [I, r. Further a function P(r was introduced, which at any step gives us the probability of "success". The maximum index value increase for the all period of time [T, 2T] will be equal nS, and the maximum possible reduction will be equal nI. Then let x ∈ [nI, nS]. This segment will reflect every possible total variation that we can get at the end of a period of time [T, 2T]. The further introduced inequality k ≥ (x - nI/(S - I gives us the minimum number of successes that needed for total changing could be in the section [x, nS] if was n - k reductions with the index value to I. Then was introduced the function r(x, kmin which is defined on the interval (nI, nS] and provided us some assurance that the total index changing could be in the section [x, nS] if successful interval is [r(x, kmin, S] and the amount of success is satisfying to our inequality. The probability of k "successes" and n - k "failures" is calculated according to the formula of Bernoulli, where the probability of "success" is determined by the function P(r, and r is determined

Simple bounds for counting processes with monotone rate of occurrence of failures

International Nuclear Information System (INIS)

Kaminskiy, Mark P.

2007-01-01

The article discusses some aspects of analogy between certain classes of distributions used as models for time to failure of nonrepairable objects, and the counting processes used as models for failure process for repairable objects. The notion of quantiles for the counting processes with strictly increasing cumulative intensity function is introduced. The classes of counting processes with increasing (decreasing) rate of occurrence of failures are considered. For these classes, the useful nonparametric bounds for cumulative intensity function based on one known quantile are obtained. These bounds, which can be used for repairable objects, are similar to the bounds introduced by Barlow and Marshall [Barlow, R. Marshall, A. Bounds for distributions with monotone hazard rate, I and II. Ann Math Stat 1964; 35: 1234-74] for IFRA (DFRA) time to failure distributions applicable to nonrepairable objects

The Monotonicity Puzzle: An Experimental Investigation of Incentive Structures

Directory of Open Access Journals (Sweden)

Jeannette Brosig

2010-05-01

Full Text Available Non-monotone incentive structures, which - according to theory - are able to induce optimal behavior, are often regarded as empirically less relevant for labor relationships. We compare the performance of a theoretically optimal non-monotone contract with a monotone one under controlled laboratory conditions. Implementing some features relevant to real-world employment relationships, our paper demonstrates that, in fact, the frequency of income-maximizing decisions made by agents is higher under the monotone contract. Although this observed behavior does not change the superiority of the non-monotone contract for principals, they do not choose this contract type in a significant way. This is what we call the monotonicity puzzle. Detailed investigations of decisions provide a clue for solving the puzzle and a possible explanation for the popularity of monotone contracts.

Studies on the zeros of Bessel functions and methods for their computation: 3. Some new works on monotonicity, convexity, and other properties

Science.gov (United States)

Kerimov, M. K.

2016-12-01

This paper continues the study of real zeros of Bessel functions begun in the previous parts of this work (see M. K. Kerimov, Comput. Math. Math. Phys. 54 (9), 1337-1388 (2014); 56 (7), 1175-1208 (2016)). Some new results regarding the monotonicity, convexity, concavity, and other properties of zeros are described. Additionally, the zeros of q-Bessel functions are investigated.

Influence of Compaction Temperature on Resistance Under Monotonic Loading of Crumb-Rubber Modified Hot-Mix Asphalts

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Hugo A. Rondón-Quintana

2012-12-01

Full Text Available The influence of compaction temperature on resistance under mono-tonic loading (Marshall of Crumb-Rubber Modified (CRM Hot-Mix As-phalt (HMA was evaluated. The emphasis of this study was the applica-tion in Bogotá D.C. (Colombia. In this city the compaction temperature of HMA mixtures decreases, compared to the optimum, in about 30°C. Two asphalt cements (AC 60-70 and AC 80-100 were modified. Two particle sizes distribution curve were used. The compaction temperatures used were 120, 130, 140 and 150°C. The decrease of the compaction tempera-ture produces a small decrease in resistance under monotonic loading of the modified mixtures tested. Mixtures without CRM undergo a lineal decrease in its resistance of up to 34%.

Influence of Compaction Temperature on Resistance Under Monotonic Loading of Crumb-Rubber Modified Hot-Mix Asphalts

Directory of Open Access Journals (Sweden)

Hugo A. Rondón-Quintana

2012-12-01

Full Text Available The influence of compaction temperature on resistance under monotonic loading (Marshall of Crumb-Rubber Modified (CRM Hot-Mix Asphalt (HMA was evaluated. The emphasis of this study was the application in Bogotá D.C. (Colombia. In this city the compaction temperature of HMA mixtures decreases, compared to the optimum, in about 30°C. Two asphalt cements (AC 60-70 and AC 80-100 were modified. Two particle sizes distribution curve were used. The compaction temperatures used were 120, 130, 140 and 150°C. The decrease of the compaction temperature produces a small decrease in resistance under monotonic loading of the modified mixtures tested. Mixtures without CRM undergo a lineal decrease in its resistance of up to 34%.

Positivity and monotonicity properties of C0-semigroups. Pt. 1

International Nuclear Information System (INIS)

Bratteli, O.; Kishimoto, A.; Robinson, D.W.

1980-01-01

If exp(-tH), exp(-tK), are self-adjoint, positivity preserving, contraction semigroups on a Hilbert space H = L 2 (X;dμ) we write esup(-tH) >= esup(-tK) >= 0 whenever exp(-tH) - exp(-tK) is positivity preserving for all t >= 0 and then we characterize the class of positive functions for which (*) always implies esup(-tf(H)) >= esup(-tf(K)) >= 0. This class consists of the f epsilon Csup(infinitely)(0, infinitely) with (-1)sup(n)fsup((n + 1))(x) >= 0, x epsilon(0, infinitely), n = 0, 1, 2, ... In particular it contains the class of monotone operator functions. Furthermore if exp(-tH) is Lsup(P)(X;dμ) contractive for all p epsilon[1, infinitely] and all t > 0 (or, equivalently, for p = infinitely and t > 0) then exp(-tf(H)) has the same property. Various applications to monotonicity properties of Green's functions are given. (orig.)

Strong monotonicity in mixed-state entanglement manipulation

International Nuclear Information System (INIS)

Ishizaka, Satoshi

2006-01-01

A strong entanglement monotone, which never increases under local operations and classical communications (LOCC), restricts quantum entanglement manipulation more strongly than the usual monotone since the usual one does not increase on average under LOCC. We propose strong monotones in mixed-state entanglement manipulation under LOCC. These are related to the decomposability and one-positivity of an operator constructed from a quantum state, and reveal geometrical characteristics of entangled states. These are lower bounded by the negativity or generalized robustness of entanglement

Comparison of boundedness and monotonicity properties of one-leg and linear multistep methods

KAUST Repository

Mozartova, A.; Savostianov, I.; Hundsdorfer, W.

2015-01-01

© 2014 Elsevier B.V. All rights reserved. One-leg multistep methods have some advantage over linear multistep methods with respect to storage of the past results. In this paper boundedness and monotonicity properties with arbitrary (semi-)norms or convex functionals are analyzed for such multistep methods. The maximal stepsize coefficient for boundedness and monotonicity of a one-leg method is the same as for the associated linear multistep method when arbitrary starting values are considered. It will be shown, however, that combinations of one-leg methods and Runge-Kutta starting procedures may give very different stepsize coefficients for monotonicity than the linear multistep methods with the same starting procedures. Detailed results are presented for explicit two-step methods.

Comparison of boundedness and monotonicity properties of one-leg and linear multistep methods

KAUST Repository

Mozartova, A.

2015-05-01

© 2014 Elsevier B.V. All rights reserved. One-leg multistep methods have some advantage over linear multistep methods with respect to storage of the past results. In this paper boundedness and monotonicity properties with arbitrary (semi-)norms or convex functionals are analyzed for such multistep methods. The maximal stepsize coefficient for boundedness and monotonicity of a one-leg method is the same as for the associated linear multistep method when arbitrary starting values are considered. It will be shown, however, that combinations of one-leg methods and Runge-Kutta starting procedures may give very different stepsize coefficients for monotonicity than the linear multistep methods with the same starting procedures. Detailed results are presented for explicit two-step methods.

Multigenerational contaminant exposures produce non-monotonic, transgenerational responses in Daphnia magna

International Nuclear Information System (INIS)

Kimberly, David A.; Salice, Christopher J.

2015-01-01

Generally, ecotoxicologists rely on short-term tests that assume populations to be static. Conversely, natural populations may be exposed to the same stressors for many generations, which can alter tolerance to the same (or other) stressors. The objective of this study was to improve our understanding of how multigenerational stressors alter life history traits and stressor tolerance. After continuously exposing Daphnia magna to cadmium for 120 days, we assessed life history traits and conducted a challenge at higher temperature and cadmium concentrations. Predictably, individuals exposed to cadmium showed an overall decrease in reproductive output compared to controls. Interestingly, control D. magna were the most cadmium tolerant to novel cadmium, followed by those exposed to high cadmium. Our data suggest that long-term exposure to cadmium alter tolerance traits in a non-monotonic way. Because we observed effects after one-generation removal from cadmium, transgenerational effects may be possible as a result of multigenerational exposure. - Highlights: • Daphnia magna exposed to cadmium for 120 days. • D. magna exposed to cadmium had decreased reproductive output. • Control D. magna were most cadmium tolerant to novel cadmium stress. • Long-term exposure to cadmium alter tolerance traits in a non-monotonic way. • Transgenerational effects observed as a result of multigenerational exposure. - Adverse effects of long-term cadmium exposure persist into cadmium free conditions, as seen by non-monotonic responses when exposed to novel stress one generation removed.

Generalized convexity, generalized monotonicity recent results

CERN Document Server

Martinez-Legaz, Juan-Enrique; Volle, Michel

1998-01-01

A function is convex if its epigraph is convex. This geometrical structure has very strong implications in terms of continuity and differentiability. Separation theorems lead to optimality conditions and duality for convex problems. A function is quasiconvex if its lower level sets are convex. Here again, the geo­ metrical structure of the level sets implies some continuity and differentiability properties for quasiconvex functions. Optimality conditions and duality can be derived for optimization problems involving such functions as well. Over a period of about fifty years, quasiconvex and other generalized convex functions have been considered in a variety of fields including economies, man­ agement science, engineering, probability and applied sciences in accordance with the need of particular applications. During the last twenty-five years, an increase of research activities in this field has been witnessed. More recently generalized monotonicity of maps has been studied. It relates to generalized conve...

Generalized bi-quasi-variational inequalities for quasi-semi-monotone and bi-quasi-semi-monotone operators with applications in non-compact settings and minimization problems

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Chowdhury Molhammad SR

2000-01-01

Full Text Available Results are obtained on existence theorems of generalized bi-quasi-variational inequalities for quasi-semi-monotone and bi-quasi-semi-monotone operators in both compact and non-compact settings. We shall use the concept of escaping sequences introduced by Border (Fixed Point Theorem with Applications to Economics and Game Theory, Cambridge University Press, Cambridge, 1985 to obtain results in non-compact settings. Existence theorems on non-compact generalized bi-complementarity problems for quasi-semi-monotone and bi-quasi-semi-monotone operators are also obtained. Moreover, as applications of some results of this paper on generalized bi-quasi-variational inequalities, we shall obtain existence of solutions for some kind of minimization problems with quasi- semi-monotone and bi-quasi-semi-monotone operators.

A Markov chain approach to modelling charge exchange processes of an ion beam in monotonically increasing or decreasing potentials

International Nuclear Information System (INIS)

Shrier, O; Khachan, J; Bosi, S

2006-01-01

A Markov chain method is presented as an alternative approach to Monte Carlo simulations of charge exchange collisions by an energetic hydrogen ion beam with a cold background hydrogen gas. This method was used to determine the average energy of the resulting energetic neutrals along the path of the beam. A comparison with Monte Carlo modelling showed a good agreement but with the advantage that it required much less computing time and produced no numerical noise. In particular, the Markov chain method works well for monotonically increasing or decreasing electrostatic potentials. Finally, a good agreement is obtained with experimental results from Doppler shift spectroscopy on energetic beams from a hollow cathode discharge. In particular, the average energy of ions that undergo charge exchange reaches a plateau that can be well below the full energy that might be expected from the applied voltage bias, depending on the background gas pressure. For example, pressures of ∼20 mTorr limit the ion energy to ∼20% of the applied voltage

CFD simulation of simultaneous monotonic cooling and surface heat transfer coefficient

International Nuclear Information System (INIS)

Mihálka, Peter; Matiašovský, Peter

2016-01-01

The monotonic heating regime method for determination of thermal diffusivity is based on the analysis of an unsteady-state (stabilised) thermal process characterised by an independence of the space-time temperature distribution on initial conditions. At the first kind of the monotonic regime a sample of simple geometry is heated / cooled at constant ambient temperature. The determination of thermal diffusivity requires the determination rate of a temperature change and simultaneous determination of the first eigenvalue. According to a characteristic equation the first eigenvalue is a function of the Biot number defined by a surface heat transfer coefficient and thermal conductivity of an analysed material. Knowing the surface heat transfer coefficient and the first eigenvalue the thermal conductivity can be determined. The surface heat transport coefficient during the monotonic regime can be determined by the continuous measurement of long-wave radiation heat flow and the photoelectric measurement of the air refractive index gradient in a boundary layer. CFD simulation of the cooling process was carried out to analyse local convective and radiative heat transfer coefficients more in detail. Influence of ambient air flow was analysed. The obtained eigenvalues and corresponding surface heat transfer coefficient values enable to determine thermal conductivity of the analysed specimen together with its thermal diffusivity during a monotonic heating regime.

On the size of monotone span programs

NARCIS (Netherlands)

Nikov, V.S.; Nikova, S.I.; Preneel, B.; Blundo, C.; Cimato, S.

2005-01-01

Span programs provide a linear algebraic model of computation. Monotone span programs (MSP) correspond to linear secret sharing schemes. This paper studies the properties of monotone span programs related to their size. Using the results of van Dijk (connecting codes and MSPs) and a construction for

Stepsize Restrictions for Boundedness and Monotonicity of Multistep Methods

KAUST Repository

Hundsdorfer, W.

2011-04-29

In this paper nonlinear monotonicity and boundedness properties are analyzed for linear multistep methods. We focus on methods which satisfy a weaker boundedness condition than strict monotonicity for arbitrary starting values. In this way, many linear multistep methods of practical interest are included in the theory. Moreover, it will be shown that for such methods monotonicity can still be valid with suitable Runge-Kutta starting procedures. Restrictions on the stepsizes are derived that are not only sufficient but also necessary for these boundedness and monotonicity properties. © 2011 Springer Science+Business Media, LLC.

Type monotonic allocation schemes for multi-glove games

OpenAIRE

Brânzei, R.; Solymosi, T.; Tijs, S.H.

2007-01-01

Multiglove markets and corresponding games are considered.For this class of games we introduce the notion of type monotonic allocation scheme.Allocation rules for multiglove markets based on weight systems are introduced and characterized.These allocation rules generate type monotonic allocation schemes for multiglove games and are also helpful in proving that each core element of the corresponding game is extendable to a type monotonic allocation scheme.The T-value turns out to generate a ty...

Almost monotonicity formulas for elliptic and parabolic operators with variable coefficients

KAUST Repository

Matevosyan, Norayr; Petrosyan, Arshak

2010-01-01

In this paper we extend the results of Caffarelli, Jerison, and Kenig [Ann. of Math. (2)155 (2002)] and Caffarelli and Kenig [Amer. J. Math.120 (1998)] by establishing an almost monotonicity estimate for pairs of continuous functions satisfying u

Non-monotonic effect of growth temperature on carrier collection in SnS solar cells

International Nuclear Information System (INIS)

Chakraborty, R.; Steinmann, V.; Mangan, N. M.; Brandt, R. E.; Poindexter, J. R.; Jaramillo, R.; Mailoa, J. P.; Hartman, K.; Polizzotti, A.; Buonassisi, T.; Yang, C.; Gordon, R. G.

2015-01-01

We quantify the effects of growth temperature on material and device properties of thermally evaporated SnS thin-films and test structures. Grain size, Hall mobility, and majority-carrier concentration monotonically increase with growth temperature. However, the charge collection as measured by the long-wavelength contribution to short-circuit current exhibits a non-monotonic behavior: the collection decreases with increased growth temperature from 150 °C to 240 °C and then recovers at 285 °C. Fits to the experimental internal quantum efficiency using an opto-electronic model indicate that the non-monotonic behavior of charge-carrier collection can be explained by a transition from drift- to diffusion-assisted components of carrier collection. The results show a promising increase in the extracted minority-carrier diffusion length at the highest growth temperature of 285 °C. These findings illustrate how coupled mechanisms can affect early stage device development, highlighting the critical role of direct materials property measurements and simulation

Estimation of Poisson-Dirichlet Parameters with Monotone Missing Data

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Xueqin Zhou

2017-01-01

Full Text Available This article considers the estimation of the unknown numerical parameters and the density of the base measure in a Poisson-Dirichlet process prior with grouped monotone missing data. The numerical parameters are estimated by the method of maximum likelihood estimates and the density function is estimated by kernel method. A set of simulations was conducted, which shows that the estimates perform well.

Monotonicity-based electrical impedance tomography for lung imaging

Science.gov (United States)

Zhou, Liangdong; Harrach, Bastian; Seo, Jin Keun

2018-04-01

This paper presents a monotonicity-based spatiotemporal conductivity imaging method for continuous regional lung monitoring using electrical impedance tomography (EIT). The EIT data (i.e. the boundary current-voltage data) can be decomposed into pulmonary, cardiac and other parts using their different periodic natures. The time-differential current-voltage operator corresponding to the lung ventilation can be viewed as either semi-positive or semi-negative definite owing to monotonic conductivity changes within the lung regions. We used these monotonicity constraints to improve the quality of lung EIT imaging. We tested the proposed methods in numerical simulations, phantom experiments and human experiments.

Regional trends in short-duration precipitation extremes: a flexible multivariate monotone quantile regression approach

Science.gov (United States)

Cannon, Alex

2017-04-01

Estimating historical trends in short-duration rainfall extremes at regional and local scales is challenging due to low signal-to-noise ratios and the limited availability of homogenized observational data. In addition to being of scientific interest, trends in rainfall extremes are of practical importance, as their presence calls into question the stationarity assumptions that underpin traditional engineering and infrastructure design practice. Even with these fundamental challenges, increasingly complex questions are being asked about time series of extremes. For instance, users may not only want to know whether or not rainfall extremes have changed over time, they may also want information on the modulation of trends by large-scale climate modes or on the nonstationarity of trends (e.g., identifying hiatus periods or periods of accelerating positive trends). Efforts have thus been devoted to the development and application of more robust and powerful statistical estimators for regional and local scale trends. While a standard nonparametric method like the regional Mann-Kendall test, which tests for the presence of monotonic trends (i.e., strictly non-decreasing or non-increasing changes), makes fewer assumptions than parametric methods and pools information from stations within a region, it is not designed to visualize detected trends, include information from covariates, or answer questions about the rate of change in trends. As a remedy, monotone quantile regression (MQR) has been developed as a nonparametric alternative that can be used to estimate a common monotonic trend in extremes at multiple stations. Quantile regression makes efficient use of data by directly estimating conditional quantiles based on information from all rainfall data in a region, i.e., without having to precompute the sample quantiles. The MQR method is also flexible and can be used to visualize and analyze the nonlinearity of the detected trend. However, it is fundamentally a

Almost monotonicity formulas for elliptic and parabolic operators with variable coefficients

KAUST Repository

Matevosyan, Norayr

2010-10-21

In this paper we extend the results of Caffarelli, Jerison, and Kenig [Ann. of Math. (2)155 (2002)] and Caffarelli and Kenig [Amer. J. Math.120 (1998)] by establishing an almost monotonicity estimate for pairs of continuous functions satisfying u± ≥ 0 Lu± ≥ -1, u+ · u_ = 0 ;in an infinite strip (global version) or a finite parabolic cylinder (localized version), where L is a uniformly parabolic operator Lu = LA,b,cu := div(A(x, s)∇u) + b(x,s) · ∇u + c(x,s)u - δsu with double Dini continuous A and uniformly bounded b and c. We also prove the elliptic counterpart of this estimate.This closes the gap between the known conditions in the literature (both in the elliptic and parabolic case) imposed on u± in order to obtain an almost monotonicity estimate.At the end of the paper, we demonstrate how to use this new almost monotonicity formula to prove the optimal C1,1-regularity in a fairly general class of quasi-linear obstacle-type free boundary problems. © 2010 Wiley Periodicals, Inc.

Stepsize Restrictions for Boundedness and Monotonicity of Multistep Methods

KAUST Repository

Hundsdorfer, W.; Mozartova, A.; Spijker, M. N.

2011-01-01

In this paper nonlinear monotonicity and boundedness properties are analyzed for linear multistep methods. We focus on methods which satisfy a weaker boundedness condition than strict monotonicity for arbitrary starting values. In this way, many

On-line learning of non-monotonic rules by simple perceptron

OpenAIRE

Inoue, Jun-ichi; Nishimori, Hidetoshi; Kabashima, Yoshiyuki

1997-01-01

We study the generalization ability of a simple perceptron which learns unlearnable rules. The rules are presented by a teacher perceptron with a non-monotonic transfer function. The student is trained in the on-line mode. The asymptotic behaviour of the generalization error is estimated under various conditions. Several learning strategies are proposed and improved to obtain the theoretical lower bound of the generalization error.

Quantitative non-monotonic modeling of economic uncertainty by probability and possibility distributions

DEFF Research Database (Denmark)

Schjær-Jacobsen, Hans

2012-01-01

uncertainty can be calculated. The possibility approach is particular well suited for representation of uncertainty of a non-statistical nature due to lack of knowledge and requires less information than the probability approach. Based on the kind of uncertainty and knowledge present, these aspects...... to the understanding of similarities and differences of the two approaches as well as practical applications. The probability approach offers a good framework for representation of randomness and variability. Once the probability distributions of uncertain parameters and their correlations are known the resulting...... are thoroughly discussed in the case of rectangular representation of uncertainty by the uniform probability distribution and the interval, respectively. Also triangular representations are dealt with and compared. Calculation of monotonic as well as non-monotonic functions of variables represented...

Monotonic Loading of Circular Surface Footings on Clay

DEFF Research Database (Denmark)

Ibsen, Lars Bo; Barari, Amin

2011-01-01

Appropriate modeling of offshore foundations under monotonic loading is a significant challenge in geotechnical engineering. This paper reports experimental and numerical analyses, specifically investigating the response of circular surface footings during monotonic loading and elastoplastic...... behavior during reloading. By using the findings presented in this paper, it is possible to extend the model to simulate the vertical-load displacement response of offshore bucket foundations....

Proofs with monotone cuts

Czech Academy of Sciences Publication Activity Database

Jeřábek, Emil

2012-01-01

Roč. 58, č. 3 (2012), s. 177-187 ISSN 0942-5616 R&D Projects: GA AV ČR IAA100190902; GA MŠk(CZ) 1M0545 Institutional support: RVO:67985840 Keywords : proof complexity * monotone sequent calculus Subject RIV: BA - General Mathematics Impact factor: 0.376, year: 2012 http://onlinelibrary.wiley.com/doi/10.1002/malq.201020071/full

Diagnosis of constant faults in iteration-free circuits over monotone basis

KAUST Repository

Alrawaf, Saad Abdullah; Chikalov, Igor; Hussain, Shahid; Moshkov, Mikhail

2014-01-01

We show that for each iteration-free combinatorial circuit S over a basis B containing only monotone Boolean functions with at most five variables, there exists a decision tree for diagnosis of constant faults on inputs of gates with depth at most 7L(S) where L(S) is the number of gates in S. © 2013 Elsevier B.V. All rights reserved.

Diagnosis of constant faults in iteration-free circuits over monotone basis

KAUST Repository

Alrawaf, Saad Abdullah

2014-03-01

We show that for each iteration-free combinatorial circuit S over a basis B containing only monotone Boolean functions with at most five variables, there exists a decision tree for diagnosis of constant faults on inputs of gates with depth at most 7L(S) where L(S) is the number of gates in S. © 2013 Elsevier B.V. All rights reserved.

Surfactants non-monotonically modify the onset of Faraday waves

Science.gov (United States)

Strickland, Stephen; Shearer, Michael; Daniels, Karen

2017-11-01

When a water-filled container is vertically vibrated, subharmonic Faraday waves emerge once the driving from the vibrations exceeds viscous dissipation. In the presence of an insoluble surfactant, a viscous boundary layer forms at the contaminated surface to balance the Marangoni and Boussinesq stresses. For linear gravity-capillary waves in an undriven fluid, the surfactant-induced boundary layer increases the amount of viscous dissipation. In our analysis and experiments, we consider whether similar effects occur for nonlinear Faraday (gravity-capillary) waves. Assuming a finite-depth, infinite-breadth, low-viscosity fluid, we derive an analytic expression for the onset acceleration up to second order in ɛ =√{ 1 / Re } . This expression allows us to include fluid depth and driving frequency as parameters, in addition to the Marangoni and Boussinesq numbers. For millimetric fluid depths and driving frequencies of 30 to 120 Hz, our analysis recovers prior numerical results and agrees with our measurements of NBD-PC surfactant on DI water. In both case, the onset acceleration increases non-monotonically as a function of Marangoni and Boussinesq numbers. For shallower systems, our model predicts that surfactants could decrease the onset acceleration. DMS-0968258.

Obliquely Propagating Non-Monotonic Double Layer in a Hot Magnetized Plasma

International Nuclear Information System (INIS)

Kim, T.H.; Kim, S.S.; Hwang, J.H.; Kim, H.Y.

2005-01-01

Obliquely propagating non-monotonic double layer is investigated in a hot magnetized plasma, which consists of a positively charged hot ion fluid and trapped, as well as free electrons. A model equation (modified Korteweg-de Vries equation) is derived by the usual reductive perturbation method from a set of basic hydrodynamic equations. A time stationary obliquely propagating non-monotonic double layer solution is obtained in a hot magnetized-plasma. This solution is an analytic extension of the monotonic double layer and the solitary hole. The effects of obliqueness, external magnetic field and ion temperature on the properties of the non-monotonic double layer are discussed

POLARIZED LINE FORMATION IN NON-MONOTONIC VELOCITY FIELDS

Energy Technology Data Exchange (ETDEWEB)

Sampoorna, M.; Nagendra, K. N., E-mail: sampoorna@iiap.res.in, E-mail: knn@iiap.res.in [Indian Institute of Astrophysics, Koramangala, Bengaluru 560034 (India)

2016-12-10

For a correct interpretation of the observed spectro-polarimetric data from astrophysical objects such as the Sun, it is necessary to solve the polarized line transfer problems taking into account a realistic temperature structure, the dynamical state of the atmosphere, a realistic scattering mechanism (namely, the partial frequency redistribution—PRD), and the magnetic fields. In a recent paper, we studied the effects of monotonic vertical velocity fields on linearly polarized line profiles formed in isothermal atmospheres with and without magnetic fields. However, in general the velocity fields that prevail in dynamical atmospheres of astrophysical objects are non-monotonic. Stellar atmospheres with shocks, multi-component supernova atmospheres, and various kinds of wave motions in solar and stellar atmospheres are examples of non-monotonic velocity fields. Here we present studies on the effect of non-relativistic non-monotonic vertical velocity fields on the linearly polarized line profiles formed in semi-empirical atmospheres. We consider a two-level atom model and PRD scattering mechanism. We solve the polarized transfer equation in the comoving frame (CMF) of the fluid using a polarized accelerated lambda iteration method that has been appropriately modified for the problem at hand. We present numerical tests to validate the CMF method and also discuss the accuracy and numerical instabilities associated with it.

Generalized Yosida Approximations Based on Relatively A-Maximal m-Relaxed Monotonicity Frameworks

Directory of Open Access Journals (Sweden)

Heng-you Lan

2013-01-01

Full Text Available We introduce and study a new notion of relatively A-maximal m-relaxed monotonicity framework and discuss some properties of a new class of generalized relatively resolvent operator associated with the relatively A-maximal m-relaxed monotone operator and the new generalized Yosida approximations based on relatively A-maximal m-relaxed monotonicity framework. Furthermore, we give some remarks to show that the theory of the new generalized relatively resolvent operator and Yosida approximations associated with relatively A-maximal m-relaxed monotone operators generalizes most of the existing notions on (relatively maximal monotone mappings in Hilbert as well as Banach space and can be applied to study variational inclusion problems and first-order evolution equations as well as evolution inclusions.

Oscillation of Nonlinear Delay Differential Equation with Non-Monotone Arguments

Directory of Open Access Journals (Sweden)

Özkan Öcalan

2017-07-01

Full Text Available Consider the first-order nonlinear retarded differential equation $$ x^{\\prime }(t+p(tf\\left( x\\left( \\tau (t\\right \\right =0, t\\geq t_{0} $$ where $p(t$ and $\\tau (t$ are function of positive real numbers such that $%\\tau (t\\leq t$ for$\\ t\\geq t_{0},\\ $and$\\ \\lim_{t\\rightarrow \\infty }\\tau(t=\\infty $. Under the assumption that the retarded argument is non-monotone, new oscillation results are given. An example illustrating the result is also given.

Monotonic and fatigue deformation of Ni--W directionally solidified eutectic

International Nuclear Information System (INIS)

Garmong, G.; Williams, J.C.

1975-01-01

Unlike many eutectic composites, the Ni--W eutectic exhibits extensive ductility by slip. Furthermore, its properties may be greatly varied by proper heat treatments. Results of studies of deformation in both monotonic and fatigue loading are reported. During monotonic deformation the fiber/matrix interface acts as a source of dislocations at low strains and an obstacle to matrix slip at higher strains. Deforming the quenched-plus-aged eutectic causes planar matrix slip, with the result that matrix slip bands create stress concentrations in the fibers at low strains. The aged eutectic reaches generally higher stress levels for comparable strains than does the as-quenched eutectic, and the failure strains decrease with increasing aging times. For the composites tested in fatigue, the aged eutectic has better high-stress fatigue resistance than the as-quenched material, but for low-stress, high-cycle fatigue their cycles to failure are nearly the same. However, both crack initiation and crack propagation are different in the two conditions, so the coincidence in high-cycle fatigue is probably fortuitous. The effect of matrix strength on composite performance is not simple, since changes in strength may be accompanied by alterations in slip modes and failure processes. (17 fig) (auth)

Transformation-invariant and nonparametric monotone smooth estimation of ROC curves.

Science.gov (United States)

Du, Pang; Tang, Liansheng

2009-01-30

When a new diagnostic test is developed, it is of interest to evaluate its accuracy in distinguishing diseased subjects from non-diseased subjects. The accuracy of the test is often evaluated by receiver operating characteristic (ROC) curves. Smooth ROC estimates are often preferable for continuous test results when the underlying ROC curves are in fact continuous. Nonparametric and parametric methods have been proposed by various authors to obtain smooth ROC curve estimates. However, there are certain drawbacks with the existing methods. Parametric methods need specific model assumptions. Nonparametric methods do not always satisfy the inherent properties of the ROC curves, such as monotonicity and transformation invariance. In this paper we propose a monotone spline approach to obtain smooth monotone ROC curves. Our method ensures important inherent properties of the underlying ROC curves, which include monotonicity, transformation invariance, and boundary constraints. We compare the finite sample performance of the newly proposed ROC method with other ROC smoothing methods in large-scale simulation studies. We illustrate our method through a real life example. Copyright (c) 2008 John Wiley & Sons, Ltd.

Iterates of piecewise monotone mappings on an interval

CERN Document Server

Preston, Chris

1988-01-01

Piecewise monotone mappings on an interval provide simple examples of discrete dynamical systems whose behaviour can be very complicated. These notes are concerned with the properties of the iterates of such mappings. The material presented can be understood by anyone who has had a basic course in (one-dimensional) real analysis. The account concentrates on the topological (as opposed to the measure theoretical) aspects of the theory of piecewise monotone mappings. As well as offering an elementary introduction to this theory, these notes also contain a more advanced treatment of the problem of classifying such mappings up to topological conjugacy.

Risk-Sensitive Control with Near Monotone Cost

International Nuclear Information System (INIS)

Biswas, Anup; Borkar, V. S.; Suresh Kumar, K.

2010-01-01

The infinite horizon risk-sensitive control problem for non-degenerate controlled diffusions is analyzed under a 'near monotonicity' condition on the running cost that penalizes large excursions of the process.

Failure mechanisms of closed-cell aluminum foam under monotonic and cyclic loading

International Nuclear Information System (INIS)

Amsterdam, E.; De Hosson, J.Th.M.; Onck, P.R.

2006-01-01

This paper concentrates on the differences in failure mechanisms of Alporas closed-cell aluminum foam under either monotonic or cyclic loading. The emphasis lies on aspects of crack nucleation and crack propagation in relation to the microstructure. The cell wall material consists of Al dendrites and an interdendritic network of Al 4 Ca and Al 22 CaTi 2 precipitates. In situ scanning electron microscopy monotonic tensile tests were performed on small samples to study crack nucleation and propagation. Digital image correlation was employed to map the strain in the cell wall on the characteristic microstructural length scale. Monotonic tensile tests and tension-tension fatigue tests were performed on larger samples to observe the overall fracture behavior and crack path in monotonic and cyclic loading. The crack nucleation and propagation path in both loading conditions are revealed and it can be concluded that during monotonic tension cracks nucleate in and propagate partly through the Al 4 Ca interdendritic network, whereas under cyclic loading cracks nucleate and propagate through the Al dendrites

Monotonicity of a Key Function Arised in Studies of Nematic Liquid Crystal Polymers

Directory of Open Access Journals (Sweden)

Hongyun Wang

2007-01-01

Full Text Available We revisit a key function arised in studies of nematic liquid crystal polymers. Previously, it was conjectured that the function is strictly decreasing and the conjecture was numerically confirmed. Here we prove the conjecture analytically. More specifically, we write the derivative of the function into two parts and prove that each part is strictly negative.

Monotone numerical methods for finite-state mean-field games

KAUST Repository

Gomes, Diogo A.; Saude, Joao

2017-01-01

Here, we develop numerical methods for finite-state mean-field games (MFGs) that satisfy a monotonicity condition. MFGs are determined by a system of differential equations with initial and terminal boundary conditions. These non-standard conditions are the main difficulty in the numerical approximation of solutions. Using the monotonicity condition, we build a flow that is a contraction and whose fixed points solve the MFG, both for stationary and time-dependent problems. We illustrate our methods in a MFG modeling the paradigm-shift problem.

Monotone numerical methods for finite-state mean-field games

KAUST Repository

Gomes, Diogo A.

2017-04-29

Here, we develop numerical methods for finite-state mean-field games (MFGs) that satisfy a monotonicity condition. MFGs are determined by a system of differential equations with initial and terminal boundary conditions. These non-standard conditions are the main difficulty in the numerical approximation of solutions. Using the monotonicity condition, we build a flow that is a contraction and whose fixed points solve the MFG, both for stationary and time-dependent problems. We illustrate our methods in a MFG modeling the paradigm-shift problem.

A discrete wavelet spectrum approach for identifying non-monotonic trends in hydroclimate data

Science.gov (United States)

Sang, Yan-Fang; Sun, Fubao; Singh, Vijay P.; Xie, Ping; Sun, Jian

2018-01-01

The hydroclimatic process is changing non-monotonically and identifying its trends is a great challenge. Building on the discrete wavelet transform theory, we developed a discrete wavelet spectrum (DWS) approach for identifying non-monotonic trends in hydroclimate time series and evaluating their statistical significance. After validating the DWS approach using two typical synthetic time series, we examined annual temperature and potential evaporation over China from 1961-2013 and found that the DWS approach detected both the warming and the warming hiatus in temperature, and the reversed changes in potential evaporation. Further, the identified non-monotonic trends showed stable significance when the time series was longer than 30 years or so (i.e. the widely defined climate timescale). The significance of trends in potential evaporation measured at 150 stations in China, with an obvious non-monotonic trend, was underestimated and was not detected by the Mann-Kendall test. Comparatively, the DWS approach overcame the problem and detected those significant non-monotonic trends at 380 stations, which helped understand and interpret the spatiotemporal variability in the hydroclimatic process. Our results suggest that non-monotonic trends of hydroclimate time series and their significance should be carefully identified, and the DWS approach proposed has the potential for wide use in the hydrological and climate sciences.

In some symmetric spaces monotonicity properties can be reduced to the cone of rearrangements

Czech Academy of Sciences Publication Activity Database

Hudzik, H.; Kaczmarek, R.; Krbec, Miroslav

2016-01-01

Roč. 90, č. 1 (2016), s. 249-261 ISSN 0001-9054 Institutional support: RVO:67985840 Keywords : symmetric spaces * K-monotone symmetric Banach spaces * strict monotonicity * lower local uniform monotonicity Subject RIV: BA - General Mathematics Impact factor: 0.826, year: 2016 http://link.springer.com/article/10.1007%2Fs00010-015-0379-6

Alternans by non-monotonic conduction velocity restitution, bistability and memory

International Nuclear Information System (INIS)

Kim, Tae Yun; Hong, Jin Hee; Heo, Ryoun; Lee, Kyoung J

2013-01-01

Conduction velocity (CV) restitution is a key property that characterizes any medium supporting traveling waves. It reflects not only the dynamics of the individual constituents but also the coupling mechanism that mediates their interaction. Recent studies have suggested that cardiac tissues, which have a non-monotonic CV-restitution property, can support alternans, a period-2 oscillatory response of periodically paced cardiac tissue. This study finds that single-hump, non-monotonic, CV-restitution curves are a common feature of in vitro cultures of rat cardiac cells. We also find that the Fenton–Karma model, one of the well-established mathematical models of cardiac tissue, supports a very similar non-monotonic CV restitution in a physiologically relevant parameter regime. Surprisingly, the mathematical model as well as the cell cultures support bistability and show cardiac memory that tends to work against the generation of an alternans. Bistability was realized by adopting two different stimulation protocols, ‘S1S2’, which produces a period-1 wave train, and ‘alternans-pacing’, which favors a concordant alternans. Thus, we conclude that the single-hump non-monotonicity in the CV-restitution curve is not sufficient to guarantee a cardiac alternans, since cardiac memory interferes and the way the system is paced matters. (paper)

Laser induced non-monotonic degradation in short-circuit current of triple-junction solar cells

Science.gov (United States)

Dou, Peng-Cheng; Feng, Guo-Bin; Zhang, Jian-Min; Song, Ming-Ying; Zhang, Zhen; Li, Yun-Peng; Shi, Yu-Bin

2018-06-01

In order to study the continuous wave (CW) laser radiation effects and mechanism of GaInP/GaAs/Ge triple-junction solar cells (TJSCs), 1-on-1 mode irradiation experiments were carried out. It was found that the post-irradiation short circuit current (ISC) of the TJSCs initially decreased and then increased with increasing of irradiation laser power intensity. To explain this phenomenon, a theoretical model had been established and then verified by post-damage tests and equivalent circuit simulations. Conclusion was drawn that laser induced alterations in the surface reflection and shunt resistance were the main causes for the observed non-monotonic decrease in the ISC of the TJSCs.

Estimating monotonic rates from biological data using local linear regression.

Science.gov (United States)

Olito, Colin; White, Craig R; Marshall, Dustin J; Barneche, Diego R

2017-03-01

Accessing many fundamental questions in biology begins with empirical estimation of simple monotonic rates of underlying biological processes. Across a variety of disciplines, ranging from physiology to biogeochemistry, these rates are routinely estimated from non-linear and noisy time series data using linear regression and ad hoc manual truncation of non-linearities. Here, we introduce the R package LoLinR, a flexible toolkit to implement local linear regression techniques to objectively and reproducibly estimate monotonic biological rates from non-linear time series data, and demonstrate possible applications using metabolic rate data. LoLinR provides methods to easily and reliably estimate monotonic rates from time series data in a way that is statistically robust, facilitates reproducible research and is applicable to a wide variety of research disciplines in the biological sciences. © 2017. Published by The Company of Biologists Ltd.

Computation of Optimal Monotonicity Preserving General Linear Methods

KAUST Repository

Ketcheson, David I.

2009-07-01

Monotonicity preserving numerical methods for ordinary differential equations prevent the growth of propagated errors and preserve convex boundedness properties of the solution. We formulate the problem of finding optimal monotonicity preserving general linear methods for linear autonomous equations, and propose an efficient algorithm for its solution. This algorithm reliably finds optimal methods even among classes involving very high order accuracy and that use many steps and/or stages. The optimality of some recently proposed methods is verified, and many more efficient methods are found. We use similar algorithms to find optimal strong stability preserving linear multistep methods of both explicit and implicit type, including methods for hyperbolic PDEs that use downwind-biased operators.

Denjoy minimal sets and Birkhoff periodic orbits for non-exact monotone twist maps

Science.gov (United States)

Qin, Wen-Xin; Wang, Ya-Nan

2018-06-01

A non-exact monotone twist map φbarF is a composition of an exact monotone twist map φ bar with a generating function H and a vertical translation VF with VF ((x , y)) = (x , y - F). We show in this paper that for each ω ∈ R, there exists a critical value Fd (ω) ≥ 0 depending on H and ω such that for 0 ≤ F ≤Fd (ω), the non-exact twist map φbarF has an invariant Denjoy minimal set with irrational rotation number ω lying on a Lipschitz graph, or Birkhoff (p , q)-periodic orbits for rational ω = p / q. Like the Aubry-Mather theory, we also construct heteroclinic orbits connecting Birkhoff periodic orbits, and show that quasi-periodic orbits in these Denjoy minimal sets can be approximated by periodic orbits. In particular, we demonstrate that at the critical value F =Fd (ω), the Denjoy minimal set is not uniformly hyperbolic and can be approximated by smooth curves.

Monotonous consumption of fibre-enriched bread at breakfast increases satiety and influences subsequent food intake.

Science.gov (United States)

Touyarou, Peio; Sulmont-Rossé, Claire; Gagnaire, Aude; Issanchou, Sylvie; Brondel, Laurent

2012-04-01

This study aimed to observe the influence of the monotonous consumption of two types of fibre-enriched bread at breakfast on hedonic liking for the bread, subsequent hunger and energy intake. Two groups of unrestrained normal weight participants were given either white sandwich bread (WS) or multigrain sandwich bread (MG) at breakfast (the sensory properties of the WS were more similar to the usual bread eaten by the participants than those of the MG). In each group, two 15-day cross-over conditions were set up. During the experimental condition the usual breakfast of each participant was replaced by an isocaloric portion of plain bread (WS or MG). During the control condition, participants consumed only 10 g of the corresponding bread and completed their breakfast with other foods they wanted. The results showed that bread appreciation did not change over exposure even in the experimental condition. Hunger was lower in the experimental condition than in the control condition. The consumption of WS decreased energy intake while the consumption of MG did not in the experimental condition compared to the corresponding control one. In conclusion, a monotonous breakfast composed solely of a fibre-enriched bread may decrease subsequent hunger and, when similar to a familiar bread, food intake. Copyright © 2011. Published by Elsevier Ltd.

A discrete wavelet spectrum approach for identifying non-monotonic trends in hydroclimate data

Directory of Open Access Journals (Sweden)

Y.-F. Sang

2018-01-01

Full Text Available The hydroclimatic process is changing non-monotonically and identifying its trends is a great challenge. Building on the discrete wavelet transform theory, we developed a discrete wavelet spectrum (DWS approach for identifying non-monotonic trends in hydroclimate time series and evaluating their statistical significance. After validating the DWS approach using two typical synthetic time series, we examined annual temperature and potential evaporation over China from 1961–2013 and found that the DWS approach detected both the warming and the warming hiatus in temperature, and the reversed changes in potential evaporation. Further, the identified non-monotonic trends showed stable significance when the time series was longer than 30 years or so (i.e. the widely defined climate timescale. The significance of trends in potential evaporation measured at 150 stations in China, with an obvious non-monotonic trend, was underestimated and was not detected by the Mann–Kendall test. Comparatively, the DWS approach overcame the problem and detected those significant non-monotonic trends at 380 stations, which helped understand and interpret the spatiotemporal variability in the hydroclimatic process. Our results suggest that non-monotonic trends of hydroclimate time series and their significance should be carefully identified, and the DWS approach proposed has the potential for wide use in the hydrological and climate sciences.

A System of Generalized Variational Inclusions Involving a New Monotone Mapping in Banach Spaces

Directory of Open Access Journals (Sweden)

Jinlin Guan

2013-01-01

Full Text Available We introduce a new monotone mapping in Banach spaces, which is an extension of the -monotone mapping studied by Nazemi (2012, and we generalize the variational inclusion involving the -monotone mapping. Based on the new monotone mapping, we propose a new proximal mapping which combines the proximal mapping studied by Nazemi (2012 with the mapping studied by Lan et al. (2011 and show its Lipschitz continuity. Based on the new proximal mapping, we give an iterative algorithm. Furthermore, we prove the convergence of iterative sequences generated by the algorithm under some appropriate conditions. Our results improve and extend corresponding ones announced by many others.

A simple algorithm for computing positively weighted straight skeletons of monotone polygons☆

Science.gov (United States)

Biedl, Therese; Held, Martin; Huber, Stefan; Kaaser, Dominik; Palfrader, Peter

2015-01-01

We study the characteristics of straight skeletons of monotone polygonal chains and use them to devise an algorithm for computing positively weighted straight skeletons of monotone polygons. Our algorithm runs in O(nlog⁡n) time and O(n) space, where n denotes the number of vertices of the polygon. PMID:25648376

A simple algorithm for computing positively weighted straight skeletons of monotone polygons.

Science.gov (United States)

Biedl, Therese; Held, Martin; Huber, Stefan; Kaaser, Dominik; Palfrader, Peter

2015-02-01

We study the characteristics of straight skeletons of monotone polygonal chains and use them to devise an algorithm for computing positively weighted straight skeletons of monotone polygons. Our algorithm runs in [Formula: see text] time and [Formula: see text] space, where n denotes the number of vertices of the polygon.

Modelling Embedded Systems by Non-Monotonic Refinement

NARCIS (Netherlands)

Mader, Angelika H.; Marincic, J.; Wupper, H.

2008-01-01

This paper addresses the process of modelling embedded sys- tems for formal verification. We propose a modelling process built on non-monotonic refinement and a number of guidelines. The outcome of the modelling process is a model, together with a correctness argument that justifies our modelling

An analysis of the stability and monotonicity of a kind of control models

Directory of Open Access Journals (Sweden)

LU Yifa

2013-06-01

Full Text Available The stability and monotonicity of control systems with parameters are considered.By the iterative relationship of the coefficients of characteristic polynomials and the Mathematica software,some sufficient conditions for the monotonicity and stability of systems are given.

Expert system for failures detection and non-monotonic reasoning

International Nuclear Information System (INIS)

Assis, Abilio de; Schirru, Roberto

1997-01-01

This paper presents the development of a shell denominated TIGER that has the purpose to serve as environment to the development of expert systems in diagnosis of faults in industrial complex plants. A model of knowledge representation and an inference engine based on non monotonic reasoning has been developed in order to provide flexibility in the representation of complex plants as well as performance to satisfy restrictions of real time. The TIGER is able to provide both the occurred fault and a hierarchical view of the several reasons that caused the fault to happen. As a validation of the developed shell a monitoring system of the critical safety functions of Angra-1 has been developed. 7 refs., 7 figs., 2 tabs

An Examination of Cooper's Test for Monotonic Trend

Science.gov (United States)

Hsu, Louis

1977-01-01

A statistic for testing monotonic trend that has been presented in the literature is shown not to be the binomial random variable it is contended to be, but rather it is linearly related to Kendall's tau statistic. (JKS)

Raman D-band in the irradiated graphene: Origin of the non-monotonous dependence of its intensity with defect concentration

International Nuclear Information System (INIS)

Codorniu Pujals, Daniel

2013-01-01

Raman spectroscopy is one of the most used experimental techniques in studying irradiated carbon nanostructures, in particular graphene, due to its high sensibility to the presence of defects in the crystalline lattice. Special attention has been given to the variation of the intensity of the Raman D-band of graphene with the concentration of defects produced by irradiation. Nowadays, there are enough experimental evidences about the non-monotonous character of that dependence, but the explanation of this behavior is still controversial. In the present work we developed a simplified mathematical model to obtain a functional relationship between these two magnitudes and showed that the non-monotonous dependence is intrinsic to the nature of the D-band and that it is not necessarily linked to amorphization processes. The obtained functional dependence was used to fit experimental data taken from other authors. The determination coefficient of the fitting was 0.96.

A note on monotone real circuits

Czech Academy of Sciences Publication Activity Database

Hrubeš, Pavel; Pudlák, Pavel

2018-01-01

Roč. 131, March (2018), s. 15-19 ISSN 0020-0190 EU Projects: European Commission(XE) 339691 - FEALORA Institutional support: RVO:67985840 Keywords : computational complexity * monotone real circuit * Karchmer-Wigderson game Subject RIV: BA - General Mathematics OBOR OECD: Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8) Impact factor: 0.748, year: 2016 http ://www.sciencedirect.com/science/article/pii/S0020019017301965?via%3Dihub

A note on monotone real circuits

Czech Academy of Sciences Publication Activity Database

Hrubeš, Pavel; Pudlák, Pavel

2018-01-01

Roč. 131, March (2018), s. 15-19 ISSN 0020-0190 EU Projects: European Commission(XE) 339691 - FEALORA Institutional support: RVO:67985840 Keywords : computational complexity * monotone real circuit * Karchmer-Wigderson game Subject RIV: BA - General Mathematics OBOR OECD: Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8) Impact factor: 0.748, year: 2016 http://www.sciencedirect.com/science/article/pii/S0020019017301965?via%3Dihub

Interval Routing and Minor-Monotone Graph Parameters

NARCIS (Netherlands)

Bakker, E.M.; Bodlaender, H.L.; Tan, R.B.; Leeuwen, J. van

2006-01-01

We survey a number of minor-monotone graph parameters and their relationship to the complexity of routing on graphs. In particular we compare the interval routing parameters κslir(G) and κsir(G) with Colin de Verdi`ere’s graph invariant μ(G) and its variants λ(G) and κ(G). We show that for all the

A Hybrid Approach to Proving Memory Reference Monotonicity

KAUST Repository

Oancea, Cosmin E.

2013-01-01

Array references indexed by non-linear expressions or subscript arrays represent a major obstacle to compiler analysis and to automatic parallelization. Most previous proposed solutions either enhance the static analysis repertoire to recognize more patterns, to infer array-value properties, and to refine the mathematical support, or apply expensive run time analysis of memory reference traces to disambiguate these accesses. This paper presents an automated solution based on static construction of access summaries, in which the reference non-linearity problem can be solved for a large number of reference patterns by extracting arbitrarily-shaped predicates that can (in)validate the reference monotonicity property and thus (dis)prove loop independence. Experiments on six benchmarks show that our general technique for dynamic validation of the monotonicity property can cover a large class of codes, incurs minimal run-time overhead and obtains good speedups. © 2013 Springer-Verlag.

The regularized monotonicity method: detecting irregular indefinite inclusions

DEFF Research Database (Denmark)

Garde, Henrik; Staboulis, Stratos

2018-01-01

inclusions, where the conductivity distribution has both more and less conductive parts relative to the background conductivity; one such method is the monotonicity method of Harrach, Seo, and Ullrich. We formulate the method for irregular indefinite inclusions, meaning that we make no regularity assumptions...

Non-monotone positive solutions of second-order linear differential equations: existence, nonexistence and criteria

Directory of Open Access Journals (Sweden)

Mervan Pašić

2016-10-01

Full Text Available We study non-monotone positive solutions of the second-order linear differential equations: $(p(tx'' + q(t x = e(t$, with positive $p(t$ and $q(t$. For the first time, some criteria as well as the existence and nonexistence of non-monotone positive solutions are proved in the framework of some properties of solutions $\\theta (t$ of the corresponding integrable linear equation: $(p(t\\theta''=e(t$. The main results are illustrated by many examples dealing with equations which allow exact non-monotone positive solutions not necessarily periodic. Finally, we pose some open questions.

New concurrent iterative methods with monotonic convergence

Energy Technology Data Exchange (ETDEWEB)

Yao, Qingchuan [Michigan State Univ., East Lansing, MI (United States)

1996-12-31

This paper proposes the new concurrent iterative methods without using any derivatives for finding all zeros of polynomials simultaneously. The new methods are of monotonic convergence for both simple and multiple real-zeros of polynomials and are quadratically convergent. The corresponding accelerated concurrent iterative methods are obtained too. The new methods are good candidates for the application in solving symmetric eigenproblems.

Non-Interior Continuation Method for Solving the Monotone Semidefinite Complementarity Problem

International Nuclear Information System (INIS)

Huang, Z.H.; Han, J.

2003-01-01

Recently, Chen and Tseng extended non-interior continuation smoothing methods for solving linear/ nonlinear complementarity problems to semidefinite complementarity problems (SDCP). In this paper we propose a non-interior continuation method for solving the monotone SDCP based on the smoothed Fischer-Burmeister function, which is shown to be globally linearly and locally quadratically convergent under suitable assumptions. Our algorithm needs at most to solve a linear system of equations at each iteration. In addition, in our analysis on global linear convergence of the algorithm, we need not use the assumption that the Frechet derivative of the function involved in the SDCP is Lipschitz continuous. For non-interior continuation/ smoothing methods for solving the nonlinear complementarity problem, such an assumption has been used widely in the literature in order to achieve global linear convergence results of the algorithms

The Bird Core for Minimum Cost Spanning Tree problems Revisited : Monotonicity and Additivity Aspects

NARCIS (Netherlands)

Tijs, S.H.; Moretti, S.; Brânzei, R.; Norde, H.W.

2005-01-01

A new way is presented to define for minimum cost spanning tree (mcst-) games the irreducible core, which is introduced by Bird in 1976.The Bird core correspondence turns out to have interesting monotonicity and additivity properties and each stable cost monotonic allocation rule for mcst-problems

Thermal effects on the enhanced ductility in non-monotonic uniaxial tension of DP780 steel sheet

Science.gov (United States)

Majidi, Omid; Barlat, Frederic; Korkolis, Yannis P.; Fu, Jiawei; Lee, Myoung-Gyu

2016-11-01

To understand the material behavior during non-monotonic loading, uniaxial tension tests were conducted in three modes, namely, the monotonic loading, loading with periodic relaxation and periodic loading-unloadingreloading, at different strain rates (0.001/s to 0.01/s). In this study, the temperature gradient developing during each test and its contribution to increasing the apparent ductility of DP780 steel sheets were considered. In order to assess the influence of temperature, isothermal uniaxial tension tests were also performed at three temperatures (298 K, 313 K and 328 K (25 °C, 40 °C and 55 °C)). A digital image correlation system coupled with an infrared thermography was used in the experiments. The results show that the non-monotonic loading modes increased the apparent ductility of the specimens. It was observed that compared with the monotonic loading, the temperature gradient became more uniform when a non-monotonic loading was applied.

A c-function for non-supersymmetric attractors

International Nuclear Information System (INIS)

Goldstein, Kevin; Jena, Rudra P.; Mandal, Gautam; Trivedi, Sandip P.

2006-01-01

We present a c-function for spherically symmetric, static and asymptotically flat solutions in theories of four-dimensional gravity coupled to gauge fields and moduli. The c-function is valid for both extremal and non-extremal black holes. It monotonically decreases from infinity and in the static region acquires its minimum value at the horizon, where it equals the entropy of the black hole. Higher dimensional cases, involving p-form gauge fields, and other generalisations are also discussed

Partial coherence with application to the monotonicity problem of coherence involving skew information

Science.gov (United States)

Luo, Shunlong; Sun, Yuan

2017-08-01

Quantifications of coherence are intensively studied in the context of completely decoherent operations (i.e., von Neuamnn measurements, or equivalently, orthonormal bases) in recent years. Here we investigate partial coherence (i.e., coherence in the context of partially decoherent operations such as Lüders measurements). A bona fide measure of partial coherence is introduced. As an application, we address the monotonicity problem of K -coherence (a quantifier for coherence in terms of Wigner-Yanase skew information) [Girolami, Phys. Rev. Lett. 113, 170401 (2014), 10.1103/PhysRevLett.113.170401], which is introduced to realize a measure of coherence as axiomatized by Baumgratz, Cramer, and Plenio [Phys. Rev. Lett. 113, 140401 (2014), 10.1103/PhysRevLett.113.140401]. Since K -coherence fails to meet the necessary requirement of monotonicity under incoherent operations, it is desirable to remedy this monotonicity problem. We show that if we modify the original measure by taking skew information with respect to the spectral decomposition of an observable, rather than the observable itself, as a measure of coherence, then the problem disappears, and the resultant coherence measure satisfies the monotonicity. Some concrete examples are discussed and related open issues are indicated.

Optimal Monotonicity-Preserving Perturbations of a Given Runge–Kutta Method

KAUST Repository

Higueras, Inmaculada

2018-02-14

Perturbed Runge–Kutta methods (also referred to as downwind Runge–Kutta methods) can guarantee monotonicity preservation under larger step sizes relative to their traditional Runge–Kutta counterparts. In this paper we study the question of how to optimally perturb a given method in order to increase the radius of absolute monotonicity (a.m.). We prove that for methods with zero radius of a.m., it is always possible to give a perturbation with positive radius. We first study methods for linear problems and then methods for nonlinear problems. In each case, we prove upper bounds on the radius of a.m., and provide algorithms to compute optimal perturbations. We also provide optimal perturbations for many known methods.

Optimal Monotonicity-Preserving Perturbations of a Given Runge–Kutta Method

KAUST Repository

Higueras, Inmaculada; Ketcheson, David I.; Kocsis, Tihamé r A.

2018-01-01

Perturbed Runge–Kutta methods (also referred to as downwind Runge–Kutta methods) can guarantee monotonicity preservation under larger step sizes relative to their traditional Runge–Kutta counterparts. In this paper we study the question of how to optimally perturb a given method in order to increase the radius of absolute monotonicity (a.m.). We prove that for methods with zero radius of a.m., it is always possible to give a perturbation with positive radius. We first study methods for linear problems and then methods for nonlinear problems. In each case, we prove upper bounds on the radius of a.m., and provide algorithms to compute optimal perturbations. We also provide optimal perturbations for many known methods.

Simple utility functions with Giffen demand

DEFF Research Database (Denmark)

Sørensen, Peter Norman

2007-01-01

Simple utility functions with the Giffen property are presented: locally, the demand curve for a good is upward sloping. The utility functions represent continuous, monotone, convex preferences......Simple utility functions with the Giffen property are presented: locally, the demand curve for a good is upward sloping. The utility functions represent continuous, monotone, convex preferences...

Error Bounds for Augmented Truncations of Discrete-Time Block-Monotone Markov Chains under Geometric Drift Conditions

OpenAIRE

Masuyama, Hiroyuki

2014-01-01

In this paper we study the augmented truncation of discrete-time block-monotone Markov chains under geometric drift conditions. We first present a bound for the total variation distance between the stationary distributions of an original Markov chain and its augmented truncation. We also obtain such error bounds for more general cases, where an original Markov chain itself is not necessarily block monotone but is blockwise dominated by a block-monotone Markov chain. Finally,...

Global Attractivity Results for Mixed-Monotone Mappings in Partially Ordered Complete Metric Spaces

Directory of Open Access Journals (Sweden)

Kalabušić S

2009-01-01

Full Text Available We prove fixed point theorems for mixed-monotone mappings in partially ordered complete metric spaces which satisfy a weaker contraction condition than the classical Banach contraction condition for all points that are related by given ordering. We also give a global attractivity result for all solutions of the difference equation , where satisfies mixed-monotone conditions with respect to the given ordering.

Error bounds for augmented truncations of discrete-time block-monotone Markov chains under subgeometric drift conditions

OpenAIRE

Masuyama, Hiroyuki

2015-01-01

This paper studies the last-column-block-augmented northwest-corner truncation (LC-block-augmented truncation, for short) of discrete-time block-monotone Markov chains under subgeometric drift conditions. The main result of this paper is to present an upper bound for the total variation distance between the stationary probability vectors of a block-monotone Markov chain and its LC-block-augmented truncation. The main result is extended to Markov chains that themselves may not be block monoton...

On stability and monotonicity requirements of finite difference approximations of stochastic conservation laws with random viscosity

KAUST Repository

Pettersson, Per

2013-05-01

The stochastic Galerkin and collocation methods are used to solve an advection-diffusion equation with uncertain and spatially varying viscosity. We investigate well-posedness, monotonicity and stability for the extended system resulting from the Galerkin projection of the advection-diffusion equation onto the stochastic basis functions. High-order summation-by-parts operators and weak imposition of boundary conditions are used to prove stability of the semi-discrete system.It is essential that the eigenvalues of the resulting viscosity matrix of the stochastic Galerkin system are positive and we investigate conditions for this to hold. When the viscosity matrix is diagonalizable, stochastic Galerkin and stochastic collocation are similar in terms of computational cost, and for some cases the accuracy is higher for stochastic Galerkin provided that monotonicity requirements are met. We also investigate the total spatial operator of the semi-discretized system and its impact on the convergence to steady-state. © 2013 Elsevier B.V.

On stability and monotonicity requirements of finite difference approximations of stochastic conservation laws with random viscosity

KAUST Repository

Pettersson, Per; Doostan, Alireza; Nordströ m, Jan

2013-01-01

The stochastic Galerkin and collocation methods are used to solve an advection-diffusion equation with uncertain and spatially varying viscosity. We investigate well-posedness, monotonicity and stability for the extended system resulting from the Galerkin projection of the advection-diffusion equation onto the stochastic basis functions. High-order summation-by-parts operators and weak imposition of boundary conditions are used to prove stability of the semi-discrete system.It is essential that the eigenvalues of the resulting viscosity matrix of the stochastic Galerkin system are positive and we investigate conditions for this to hold. When the viscosity matrix is diagonalizable, stochastic Galerkin and stochastic collocation are similar in terms of computational cost, and for some cases the accuracy is higher for stochastic Galerkin provided that monotonicity requirements are met. We also investigate the total spatial operator of the semi-discretized system and its impact on the convergence to steady-state. © 2013 Elsevier B.V.

Pathwise duals of monotone and additive Markov processes

Czech Academy of Sciences Publication Activity Database

Sturm, A.; Swart, Jan M.

-, - (2018) ISSN 0894-9840 R&D Projects: GA ČR GAP201/12/2613 Institutional support: RVO:67985556 Keywords : pathwise duality * monotone Markov process * additive Markov process * interacting particle system Subject RIV: BA - General Mathematics Impact factor: 0.854, year: 2016 http://library.utia.cas.cz/separaty/2016/SI/swart-0465436.pdf

The relation between majorization theory and quantum information from entanglement monotones perspective

Energy Technology Data Exchange (ETDEWEB)

Erol, V. [Department of Computer Engineering, Institute of Science, Okan University, Istanbul (Turkey); Netas Telecommunication Inc., Istanbul (Turkey)

2016-04-21

Entanglement has been studied extensively for understanding the mysteries of non-classical correlations between quantum systems. In the bipartite case, there are well known monotones for quantifying entanglement such as concurrence, relative entropy of entanglement (REE) and negativity, which cannot be increased via local operations. The study on these monotones has been a hot topic in quantum information [1-7] in order to understand the role of entanglement in this discipline. It can be observed that from any arbitrary quantum pure state a mixed state can obtained. A natural generalization of this observation would be to consider local operations classical communication (LOCC) transformations between general pure states of two parties. Although this question is a little more difficult, a complete solution has been developed using the mathematical framework of the majorization theory [8]. In this work, we analyze the relation between entanglement monotones concurrence and negativity with respect to majorization for general two-level quantum systems of two particles.

Generalized monotonicity from global minimization in fourth-order ODEs

NARCIS (Netherlands)

M.A. Peletier (Mark)

2000-01-01

textabstractWe consider solutions of the stationary Extended Fisher-Kolmogorov equation with general potential that are global minimizers of an associated variational problem. We present results that relate the global minimization property to a generalized concept of monotonicity of the solutions.

Decreases in soil microbial function and functional diversity in response to depleted uranium

International Nuclear Information System (INIS)

Meyer, M.C.; Paschke, M.W.; McLendon, T.

1998-01-01

A soil microcosm experiment was used to analyze effects of depleted uranium (DU) on soil function, and the concomitant changes in bacterial functional diversity. Uranium treatment levels were 0, 50, 500, 5000, 10,000 and 25,000 mg DU kg -1 soil. Three measures of soil function were made. Overall soil biological activity was assessed via measurement of soil respiration. Decomposition was assessed by measurement of mass loss of four different plant litter types: wood sticks, cellulose paper, high-N grass, and low-N grass. Mineral N availability in the microcosms was estimated using ion-exchange resin bags. Functional diversity of the microcosms was analyzed through the use of the Biolog-system of sole-C-utilization patterns. Soil respiration was the most sensitive measure of functional changes, with significant decreases observed starting at the 500 mg kg -1 treatment. No differences in N availability were observed across the U treatments. Litter decomposition was significantly decreased at the 25,000 mg kg -1 level relative to the control for all litter types except the high-N grass. Wood decomposition was reduced by 84% at the 25,000 mg kg - treatment, cellulose paper by 68%, and low-N grass by 15%. Decreases in the functional diversity of the bacterial community were related to the observed decrease in soil respiration, and to the greater effect on decomposition of the lower-quality litter types

Monotone methods for solving a boundary value problem of second order discrete system

Directory of Open Access Journals (Sweden)

Wang Yuan-Ming

1999-01-01

Full Text Available A new concept of a pair of upper and lower solutions is introduced for a boundary value problem of second order discrete system. A comparison result is given. An existence theorem for a solution is established in terms of upper and lower solutions. A monotone iterative scheme is proposed, and the monotone convergence rate of the iteration is compared and analyzed. The numerical results are given.

Autoimmune Response Confers Decreased Cardiac Function in ...

African Journals Online (AJOL)

inflammatory response; rather, autoimmune response would keep affecting decreased heart function in. RHD patients who ... untreated children. Nearly 30 - 45 % of the affected children could ..... Technology Department of Anhui Province (PR.

PENGARUH MONOTON, KUALITAS TIDUR, PSIKOFISIOLOGI, DISTRAKSI, DAN KELELAHAN KERJA TERHADAP TINGKAT KEWASPADAAN

Directory of Open Access Journals (Sweden)

Wiwik Budiawan

2016-02-01

Full Text Available Manusia sebagai subyek yang memiliki keterbatasan dalam kerja, sehingga menyebabkan terjadinya kesalahan. Kesalahan manusia yang dilakukan mengakibatkan menurunnya tingkat kewaspadaan masinis dan asisten masinis dalam menjalankan tugas. Tingkat kewaspadaan dipengaruhi oleh 5 faktor yaitu keadaan monoton, kualitas tidur, keadaan psikofisiologi, distraksi dan kelelahan kerja. Metode untuk mengukur 5 faktor yaitu kuisioner mononton, kuisioner Pittsburgh Sleep Quality Index (PSQI, kuisioner General Job Stress dan kuisioner FAS. Sedangkan untuk menguji tingkat kewaspadaan menggunakan Software Psychomotor Vigilance Test (PVT. Responden yang dipilih adalah masinis dan asisten masinis, karena jenis pekerjaan tersebut sangat membutuhkan tingkat kewaspadaan yang tinggi. Hasil pengukuran kemudian dianalisa menggunakan uji regresi linear majemuk. Dalam penelitian ini menghasilkan keadaan monoton, kualitas tidur, keadaan psikofisiologi, distraksi dan kelelahan kerja berpengaruh secara simultan terhadap tingkat kewaspadaan. Hal ini dibuktikan dengan ketika sebelum jam dinas, hasil uji F-hitung keadaan monoton, kualitas tidur, keadaan psikofisiologi adalah sebesar 0,876, sedangkan untuk variabel distraksi dan Kelelahan Kerja (FAS terhadap tingkat kewaspadaan memiliki nilai 2,371. pada saat sesudah bekerja variabel distraksi dan kelelahan kerja (FAS terhadap tingkat kewaspadaan memiliki nilai F-hitung 2,953,dan nilai 0,544 untuk keadaan monoton, kualitas tidur, keadaan psikofisiologi. Faktor yang memiliki pengaruh terbesar terhadap tingkat kewaspadaan sebelum jam dinas yaitu faktor kualitas tidur, sedangkan untuk sesudah jam dinas adalah faktor kelelahan kerja.     Abstract Human beings as subjects who have limitations in work, thus causing the error. Human error committed resulted in a decreased level of alertness machinist and assistant machinist in the line of duty. Alert level is influenced by five factors: the state of monotony, quality of sleep

Monotone viable trajectories for functional differential inclusions

Science.gov (United States)

Haddad, Georges

This paper is a study on functional differential inclusions with memory which represent the multivalued version of retarded functional differential equations. The main result gives a necessary and sufficient equations. The main result gives a necessary and sufficient condition ensuring the existence of viable trajectories; that means trajectories remaining in a given nonempty closed convex set defined by given constraints the system must satisfy to be viable. Some motivations for this paper can be found in control theory where F( t, φ) = { f( t, φ, u)} uɛU is the set of possible velocities of the system at time t, depending on the past history represented by the function φ and on a control u ranging over a set U of controls. Other motivations can be found in planning procedures in microeconomics and in biological evolutions where problems with memory do effectively appear in a multivalued version. All these models require viability constraints represented by a closed convex set.

The Monotonic Lagrangian Grid for Fast Air-Traffic Evaluation

Science.gov (United States)

Alexandrov, Natalia; Kaplan, Carolyn; Oran, Elaine; Boris, Jay

2010-01-01

This paper describes the continued development of a dynamic air-traffic model, ATMLG, intended for rapid evaluation of rules and methods to control and optimize transport systems. The underlying data structure is based on the Monotonic Lagrangian Grid (MLG), which is used for sorting and ordering positions and other data needed to describe N moving bodies, and their interactions. In ATMLG, the MLG is combined with algorithms for collision avoidance and updating aircraft trajectories. Aircraft that are close to each other in physical space are always near neighbors in the MLG data arrays, resulting in a fast nearest-neighbor interaction algorithm that scales as N. In this paper, we use ATMLG to examine how the ability to maintain a required separation between aircraft decreases as the number of aircraft in the volume increases. This requires keeping track of the primary and subsequent collision avoidance maneuvers necessary to maintain a five mile separation distance between all aircraft. Simulation results show that the number of collision avoidance moves increases exponentially with the number of aircraft in the volume.

Non-Monotonic Survival of Staphylococcus aureus with Respect to Ciprofloxacin Concentration Arises from Prophage-Dependent Killing of Persisters

Directory of Open Access Journals (Sweden)

Elizabeth L. Sandvik

2015-11-01

Full Text Available Staphylococcus aureus is a notorious pathogen with a propensity to cause chronic, non-healing wounds. Bacterial persisters have been implicated in the recalcitrance of S. aureus infections, and this motivated us to examine the persistence of S. aureus to ciprofloxacin, a quinolone antibiotic. Upon treatment of exponential phase S. aureus with ciprofloxacin, we observed that survival was a non-monotonic function of ciprofloxacin concentration. Maximal killing occurred at 1 µg/mL ciprofloxacin, which corresponded to survival that was up to ~40-fold lower than that obtained with concentrations ≥ 5 µg/mL. Investigation of this phenomenon revealed that the non-monotonic response was associated with prophage induction, which facilitated killing of S. aureus persisters. Elimination of prophage induction with tetracycline was found to prevent cell lysis and persister killing. We anticipate that these findings may be useful for the design of quinolone treatments.

The product of capacities and belief functions

DEFF Research Database (Denmark)

Hendon, Ebbe; Whitta-Jacobsen, Hans Jørgen; Sloth, Birgitte

1996-01-01

Capacities (monotone, non-additive set functions) have been suggested to describe situations of uncertainty. We examine the question of how to define the product of two independent capacities. In particular, for the product of two belief functions (totally monotone capacities), there is a unique...... minimal product belief function. This is characterized in several ways...

The product of capacities and belief functions

DEFF Research Database (Denmark)

Hendon, Ebbe; Jacobsen, Hans Jørgen; Sloth, Birgitte

1996-01-01

Capacities (monotone, non-additive set functions) have been suggested to describe situations of uncertainty. We examine the question of how to define the product of two independent capacities. In particular, for the product of two belief functions (totally monotone capacities), there is a unique...... minimal product belief function. This is characterized in several ways....

Non-monotonic resonance in a spatially forced Lengyel-Epstein model

Energy Technology Data Exchange (ETDEWEB)

Haim, Lev [Physics Department, Ben-Gurion University of the Negev, Beer-Sheva 84105 (Israel); Department of Oncology, Soroka University Medical Center, Beer-Sheva 84101 (Israel); Hagberg, Aric [Center for Nonlinear Studies, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Meron, Ehud [Physics Department, Ben-Gurion University of the Negev, Beer-Sheva 84105 (Israel); Department of Solar Energy and Environmental Physics, BIDR, Ben-Gurion University of the Negev, Sede Boqer Campus, Midreshet Ben-Gurion 84990 (Israel)

2015-06-15

We study resonant spatially periodic solutions of the Lengyel-Epstein model modified to describe the chlorine dioxide-iodine-malonic acid reaction under spatially periodic illumination. Using multiple-scale analysis and numerical simulations, we obtain the stability ranges of 2:1 resonant solutions, i.e., solutions with wavenumbers that are exactly half of the forcing wavenumber. We show that the width of resonant wavenumber response is a non-monotonic function of the forcing strength, and diminishes to zero at sufficiently strong forcing. We further show that strong forcing may result in a π/2 phase shift of the resonant solutions, and argue that the nonequilibrium Ising-Bloch front bifurcation can be reversed. We attribute these behaviors to an inherent property of forcing by periodic illumination, namely, the increase of the mean spatial illumination as the forcing amplitude is increased.

Theoretical and experimental study of non-monotonous effects

International Nuclear Information System (INIS)

Delforge, J.

1977-01-01

In recent years, the study of the effects of low dose rates has expanded considerably, especially in connection with current problems concerning the environment and health physics. After having made a precise definition of the different types of non-monotonous effect which may be encountered, for each the main experimental results known are indicated, as well as the principal consequences which may be expected. One example is the case of radiotherapy, where there is a chance of finding irradiation conditions such that the ratio of destructive action on malignant cells to healthy cells is significantly improved. In the second part of the report, the appearance of these phenomena, especially at low dose rates are explained. For this purpose, the theory of transformation systems of P. Delattre is used as a theoretical framework. With the help of a specific example, it is shown that non-monotonous effects are frequently encountered, especially when the overall effect observed is actually the sum of several different elementary effects (e.g. in survival curves, where death may be due to several different causes), or when the objects studied possess inherent kinetics not limited to restoration phenomena alone (e.g. cellular cycle) [fr

How do people learn from negative evidence? Non-monotonic generalizations and sampling assumptions in inductive reasoning.

Science.gov (United States)

Voorspoels, Wouter; Navarro, Daniel J; Perfors, Amy; Ransom, Keith; Storms, Gert

2015-09-01

A robust finding in category-based induction tasks is for positive observations to raise the willingness to generalize to other categories while negative observations lower the willingness to generalize. This pattern is referred to as monotonic generalization. Across three experiments we find systematic non-monotonicity effects, in which negative observations raise the willingness to generalize. Experiments 1 and 2 show that this effect emerges in hierarchically structured domains when a negative observation from a different category is added to a positive observation. They also demonstrate that this is related to a specific kind of shift in the reasoner's hypothesis space. Experiment 3 shows that the effect depends on the assumptions that the reasoner makes about how inductive arguments are constructed. Non-monotonic reasoning occurs when people believe the facts were put together by a helpful communicator, but monotonicity is restored when they believe the observations were sampled randomly from the environment. Copyright © 2015 Elsevier Inc. All rights reserved.

Statistical analysis of sediment toxicity by additive monotone regression splines

NARCIS (Netherlands)

Boer, de W.J.; Besten, den P.J.; Braak, ter C.J.F.

2002-01-01

Modeling nonlinearity and thresholds in dose-effect relations is a major challenge, particularly in noisy data sets. Here we show the utility of nonlinear regression with additive monotone regression splines. These splines lead almost automatically to the estimation of thresholds. We applied this

Monotone matrix transformations defined by the group inverse and simultaneous diagonalizability

International Nuclear Information System (INIS)

Bogdanov, I I; Guterman, A E

2007-01-01

Bijective linear transformations of the matrix algebra over an arbitrary field that preserve simultaneous diagonalizability are characterized. This result is used for the characterization of bijective linear monotone transformations . Bibliography: 28 titles.

Scaling laws for dislocation microstructures in monotonic and cyclic deformation of fcc metals

International Nuclear Information System (INIS)

Kubin, L.P.; Sauzay, M.

2011-01-01

This work reviews and critically discusses the current understanding of two scaling laws, which are ubiquitous in the modeling of monotonic plastic deformation in face-centered cubic metals. A compilation of the available data allows extending the domain of application of these scaling laws to cyclic deformation. The strengthening relation tells that the flow stress is proportional to the square root of the average dislocation density, whereas the similitude relation assumes that the flow stress is inversely proportional to the characteristic wavelength of dislocation patterns. The strengthening relation arises from short-range reactions of non-coplanar segments and applies all through the first three stages of the monotonic stress vs. strain curves. The value of the proportionality coefficient is calculated and simulated in good agreement with the bulk of experimental measurements published since the beginning of the 1960's. The physical origin of what is called similitude is not understood and the related coefficient is not predictable. Its value is determined from a review of the experimental literature. The generalization of these scaling laws to cyclic deformation is carried out on the base of a large collection of experimental results on single and polycrystals of various materials and on different microstructures. Surprisingly, for persistent slip bands (PSBs), both the strengthening and similitude coefficients appear to be more than two times smaller than the corresponding monotonic values, whereas their ratio is the same as in monotonic deformation. The similitude relation is also checked in cell structures and in labyrinth structures. Under low cyclic stresses, the strengthening coefficient is found even lower than in PSBs. A tentative explanation is proposed for the differences observed between cyclic and monotonic deformation. Finally, the influence of cross-slip on the temperature dependence of the saturation stress of PSBs is discussed in some detail

Brain 'talks over' boring quotes: top-down activation of voice-selective areas while listening to monotonous direct speech quotations.

Science.gov (United States)

Yao, Bo; Belin, Pascal; Scheepers, Christoph

2012-04-15

In human communication, direct speech (e.g., Mary said, "I'm hungry") is perceived as more vivid than indirect speech (e.g., Mary said that she was hungry). This vividness distinction has previously been found to underlie silent reading of quotations: Using functional magnetic resonance imaging (fMRI), we found that direct speech elicited higher brain activity in the temporal voice areas (TVA) of the auditory cortex than indirect speech, consistent with an "inner voice" experience in reading direct speech. Here we show that listening to monotonously spoken direct versus indirect speech quotations also engenders differential TVA activity. This suggests that individuals engage in top-down simulations or imagery of enriched supra-segmental acoustic representations while listening to monotonous direct speech. The findings shed new light on the acoustic nature of the "inner voice" in understanding direct speech. Copyright © 2012 Elsevier Inc. All rights reserved.

Monotone difference schemes for weakly coupled elliptic and parabolic systems

NARCIS (Netherlands)

P. Matus (Piotr); F.J. Gaspar Lorenz (Franscisco); L. M. Hieu (Le Minh); V.T.K. Tuyen (Vo Thi Kim)

2017-01-01

textabstractThe present paper is devoted to the development of the theory of monotone difference schemes, approximating the so-called weakly coupled system of linear elliptic and quasilinear parabolic equations. Similarly to the scalar case, the canonical form of the vector-difference schemes is

Monotone Comparative Statics for the Industry Composition

DEFF Research Database (Denmark)

Laugesen, Anders Rosenstand; Bache, Peter Arendorf

2015-01-01

We let heterogeneous firms face decisions on a number of complementary activities in a monopolistically-competitive industry. The endogenous level of competition and selection regarding entry and exit of firms introduces a wedge between monotone comparative statics (MCS) at the firm level and MCS...... for the industry composition. The latter phenomenon is defined as first-order stochastic dominance shifts in the equilibrium distributions of all activities across active firms. We provide sufficient conditions for MCS at both levels of analysis and show that we may have either type of MCS without the other...

Periodontal Disease and Decreased Kidney Function in Japanese Elderly

NARCIS (Netherlands)

Iwasaki, Masanori; Taylor, George W.; Nesse, Willem; Vissink, Arjan; Yoshihara, Akihiro; Miyazaki, Hideo

Background: Early detection of decreased kidney function can help prevent the progression of kidney disease to kidney failure and cardiovascular events. Potentially significant associations between kidney function and periodontal disease have been reported in cross-sectional studies. However, no

Inequalities for the Modified k-Bessel Function

Directory of Open Access Journals (Sweden)

Saiful Rahman Mondal

2017-07-01

Full Text Available The article considers the generalized k-Bessel functions and represents it as Wright functions. Then we study the monotonicity properties of the ratio of two different orders k- Bessel functions, and the ratio of the k-Bessel and the k-Bessel functions. The log-convexity with respect to the order of the k-Bessel also given. An investigation regarding the monotonicity of the ratio of the k-Bessel and k-confluent hypergeometric functions are discussed.

Sampling from a Discrete Distribution While Preserving Monotonicity.

Science.gov (United States)

1982-02-01

in a table beforehand, this procedure, known as the inverse transform method, requires n storage spaces and EX comparisons on average, which may prove...limitations that deserve attention: a. In general, the alias method does not preserve a monotone relationship between U and X as does the inverse transform method...uses the inverse transform approach but with more information computed beforehand, as in the alias method. The proposed method is not new having been

Martensitic Transformation in Ultrafine-Grained Stainless Steel AISI 304L Under Monotonic and Cyclic Loading

Directory of Open Access Journals (Sweden)

Heinz Werner Höppel

2012-02-01

Full Text Available The monotonic and cyclic deformation behavior of ultrafine-grained metastable austenitic steel AISI 304L, produced by severe plastic deformation, was investigated. Under monotonic loading, the martensitic phase transformation in the ultrafine-grained state is strongly favored. Under cyclic loading, the martensitic transformation behavior is similar to the coarse-grained condition, but the cyclic stress response is three times larger for the ultrafine-grained condition.

Existence, uniqueness, monotonicity and asymptotic behaviour of travelling waves for epidemic models

International Nuclear Information System (INIS)

Hsu, Cheng-Hsiung; Yang, Tzi-Sheng

2013-01-01

The purpose of this work is to investigate the existence, uniqueness, monotonicity and asymptotic behaviour of travelling wave solutions for a general epidemic model arising from the spread of an epidemic by oral–faecal transmission. First, we apply Schauder's fixed point theorem combining with a supersolution and subsolution pair to derive the existence of positive monotone monostable travelling wave solutions. Then, applying the Ikehara's theorem, we determine the exponential rates of travelling wave solutions which converge to two different equilibria as the moving coordinate tends to positive infinity and negative infinity, respectively. Finally, using the sliding method, we prove the uniqueness result provided the travelling wave solutions satisfy some boundedness conditions. (paper)

The effect of the electrical double layer on hydrodynamic lubrication: a non-monotonic trend with increasing zeta potential

Directory of Open Access Journals (Sweden)

Dalei Jing

2017-07-01

Full Text Available In the present study, a modified Reynolds equation including the electrical double layer (EDL-induced electroviscous effect of lubricant is established to investigate the effect of the EDL on the hydrodynamic lubrication of a 1D slider bearing. The theoretical model is based on the nonlinear Poisson–Boltzmann equation without the use of the Debye–Hückel approximation. Furthermore, the variation in the bulk electrical conductivity of the lubricant under the influence of the EDL is also considered during the theoretical analysis of hydrodynamic lubrication. The results show that the EDL can increase the hydrodynamic load capacity of the lubricant in a 1D slider bearing. More importantly, the hydrodynamic load capacity of the lubricant under the influence of the EDL shows a non-monotonic trend, changing from enhancement to attenuation with a gradual increase in the absolute value of the zeta potential. This non-monotonic hydrodynamic lubrication is dependent on the non-monotonic electroviscous effect of the lubricant generated by the EDL, which is dominated by the non-monotonic electrical field strength and non-monotonic electrical body force on the lubricant. The subject of the paper is the theoretical modeling and the corresponding analysis.

Modelling the drained response of bucket foundations for offshore wind turbines under general monotonic and cyclic loading

DEFF Research Database (Denmark)

Foglia, Aligi; Gottardi, Guido; Govoni, Laura

2015-01-01

The response of bucket foundations on sand subjected to planar monotonic and cyclic loading is investigated in the paper. Thirteen monotonic and cyclic laboratory tests on a skirted footing model having a 0.3 m diameter and embedment ratio equal to 1 are presented. The loading regime reproduces t...

Experimental quantum control landscapes: Inherent monotonicity and artificial structure

International Nuclear Information System (INIS)

Roslund, Jonathan; Rabitz, Herschel

2009-01-01

Unconstrained searches over quantum control landscapes are theoretically predicted to generally exhibit trap-free monotonic behavior. This paper makes an explicit experimental demonstration of this intrinsic monotonicity for two controlled quantum systems: frequency unfiltered and filtered second-harmonic generation (SHG). For unfiltered SHG, the landscape is randomly sampled and interpolation of the data is found to be devoid of landscape traps up to the level of data noise. In the case of narrow-band-filtered SHG, trajectories are taken on the landscape to reveal a lack of traps. Although the filtered SHG landscape is trap free, it exhibits a rich local structure. A perturbation analysis around the top of these landscapes provides a basis to understand their topology. Despite the inherent trap-free nature of the landscapes, practical constraints placed on the controls can lead to the appearance of artificial structure arising from the resultant forced sampling of the landscape. This circumstance and the likely lack of knowledge about the detailed local landscape structure in most quantum control applications suggests that the a priori identification of globally successful (un)constrained curvilinear control variables may be a challenging task.

Non-monotonic reasoning in conceptual modeling and ontology design: A proposal

CSIR Research Space (South Africa)

Casini, G

2013-06-01

Full Text Available -1 2nd International Workshop on Ontologies and Conceptual Modeling (Onto.Com 2013), Valencia, Spain, 17-21 June 2013 Non-monotonic reasoning in conceptual modeling and ontology design: A proposal Giovanni Casini1 and Alessandro Mosca2 1...

Monotonous braking of high energy hadrons in nuclear matter

International Nuclear Information System (INIS)

Strugalski, Z.

1979-01-01

Propagation of high energy hadrons in nuclear matter is discussed. The possibility of the existence of the monotonous energy losses of hadrons in nuclear matter is considered. In favour of this hypothesis experimental facts such as pion-nucleus interactions (proton emission spectra, proton multiplicity distributions in these interactions) and other data are presented. The investigated phenomenon in the framework of the hypothesis is characterized in more detail

Quantisation of monotonic twist maps

International Nuclear Information System (INIS)

Boasman, P.A.; Smilansky, U.

1993-08-01

Using an approach suggested by Moser, classical Hamiltonians are generated that provide an interpolating flow to the stroboscopic motion of maps with a monotonic twist condition. The quantum properties of these Hamiltonians are then studied in analogy with recent work on the semiclassical quantization of systems based on Poincare surfaces of section. For the generalized standard map, the correspondence with the usual classical and quantum results is shown, and the advantages of the quantum Moser Hamiltonian demonstrated. The same approach is then applied to the free motion of a particle on a 2-torus, and to the circle billiard. A natural quantization condition based on the eigenphases of the unitary time--development operator is applied, leaving the exact eigenvalues of the torus, but only the semiclassical eigenvalues for the billiard; an explanation for this failure is proposed. It is also seen how iterating the classical map commutes with the quantization. (authors)

The period function of the generalized Lotka-Volterra centers

Science.gov (United States)

Villadelprat, J.

2008-05-01

The present paper deals with the period function of the quadratic centers. In the literature different terminologies are used to classify these centers, but essentially there are four families: Hamiltonian, reversible , codimension four Q4 and generalized Lotka-Volterra systems . Chicone [C. Chicone, Review in MathSciNet, Ref. 94h:58072] conjectured that the reversible centers have at most two critical periods, and that the centers of the three other families have a monotonic period function. With regard to the second part of this conjecture, only the monotonicity of the Hamiltonian and Q4 families [W.A. Coppel, L. Gavrilov, The period function of a Hamiltonian quadratic system, Differential Integral Equations 6 (1993) 1357-1365; Y. Zhao, The monotonicity of period function for codimension four quadratic system Q4, J. Differential Equations 185 (2002) 370-387] has been proved. Concerning the family, no substantial progress has been made since the middle 80s, when several authors showed independently the monotonicity of the classical Lotka-Volterra centers [F. Rothe, The periods of the Volterra-Lokta system, J. Reine Angew. Math. 355 (1985) 129-138; R. Schaaf, Global behaviour of solution branches for some Neumann problems depending on one or several parameters, J. Reine Angew. Math. 346 (1984) 1-31; J. Waldvogel, The period in the Lotka-Volterra system is monotonic, J. Math. Anal. Appl. 114 (1986) 178-184]. By means of the first period constant one can easily conclude that the period function of the centers in the family is monotone increasing near the inner boundary of its period annulus (i.e., the center itself). Thus, according to Chicone's conjecture, it should be also monotone increasing near the outer boundary, which in the Poincaré disc is a polycycle. In this paper we show that this is true. In addition we prove that, except for a zero measure subset of the parameter plane, there is no bifurcation of critical periods from the outer boundary. Finally we

On utilization bounds for a periodic resource under rate monotonic scheduling

NARCIS (Netherlands)

Renssen, van A.M.; Geuns, S.J.; Hausmans, J.P.H.M.; Poncin, W.; Bril, R.J.

2009-01-01

This paper revisits utilization bounds for a periodic resource under the rate monotonic (RM) scheduling algorithm. We show that the existing utilization bound, as presented in [8, 9], is optimistic. We subsequently show that by viewing the unavailability of the periodic resource as a deferrable

Monotonous property of non-oscillations of the damped Duffing's equation

International Nuclear Information System (INIS)

Feng Zhaosheng

2006-01-01

In this paper, we give a qualitative study to the damped Duffing's equation by means of the qualitative theory of planar systems. Under certain parametric conditions, the monotonous property of the bounded non-oscillations is obtained. Explicit exact solutions are obtained by a direct method and application of this approach to a reaction-diffusion equation is presented

On monotonic solutions of an integral equation of Abel type

International Nuclear Information System (INIS)

Darwish, Mohamed Abdalla

2007-08-01

We present an existence theorem of monotonic solutions for a quadratic integral equation of Abel type in C[0, 1]. The famous Chandrasekhar's integral equation is considered as a special case. The concept of measure of noncompactness and a fi xed point theorem due to Darbo are the main tools in carrying out our proof. (author)

Decreased function of survival motor neuron protein impairs endocytic pathways.

Science.gov (United States)

Dimitriadi, Maria; Derdowski, Aaron; Kalloo, Geetika; Maginnis, Melissa S; O'Hern, Patrick; Bliska, Bryn; Sorkaç, Altar; Nguyen, Ken C Q; Cook, Steven J; Poulogiannis, George; Atwood, Walter J; Hall, David H; Hart, Anne C

2016-07-26

Spinal muscular atrophy (SMA) is caused by depletion of the ubiquitously expressed survival motor neuron (SMN) protein, with 1 in 40 Caucasians being heterozygous for a disease allele. SMN is critical for the assembly of numerous ribonucleoprotein complexes, yet it is still unclear how reduced SMN levels affect motor neuron function. Here, we examined the impact of SMN depletion in Caenorhabditis elegans and found that decreased function of the SMN ortholog SMN-1 perturbed endocytic pathways at motor neuron synapses and in other tissues. Diminished SMN-1 levels caused defects in C. elegans neuromuscular function, and smn-1 genetic interactions were consistent with an endocytic defect. Changes were observed in synaptic endocytic proteins when SMN-1 levels decreased. At the ultrastructural level, defects were observed in endosomal compartments, including significantly fewer docked synaptic vesicles. Finally, endocytosis-dependent infection by JC polyomavirus (JCPyV) was reduced in human cells with decreased SMN levels. Collectively, these results demonstrate for the first time, to our knowledge, that SMN depletion causes defects in endosomal trafficking that impair synaptic function, even in the absence of motor neuron cell death.

A note on profit maximization and monotonicity for inbound call centers

NARCIS (Netherlands)

Koole, G.M.; Pot, S.A.

2011-01-01

We consider an inbound call center with a fixed reward per call and communication and agent costs. By controlling the number of lines and the number of agents, we can maximize the profit. Abandonments are included in our performance model. Monotonicity results for the maximization problem are

Effect of dynamic monotonic and cyclic loading on fracture behavior for Japanese carbon steel pipe STS410

Energy Technology Data Exchange (ETDEWEB)

Kinoshita, Kanji; Murayama, Kouichi; Ogata, Hiroyuki [and others

1997-04-01

The fracture behavior for Japanese carbon steel pipe STS410 was examined under dynamic monotonic and cyclic loading through a research program of International Piping Integrity Research Group (EPIRG-2), in order to evaluate the strength of pipe during the seismic event The tensile test and the fracture toughness test were conducted for base metal and TIG weld metal. Three base metal pipe specimens, 1,500mm in length and 6-inch diameter sch.120, were employed for a quasi-static monotonic, a dynamic monotonic and a dynamic cyclic loading pipe fracture tests. One weld joint pipe specimen was also employed for a dynamic cyclic loading test In the dynamic cyclic loading test, the displacement was controlled as applying the fully reversed load (R=-1). The pipe specimens with a circumferential through-wall crack were subjected four point bending load at 300C in air. Japanese STS410 carbon steel pipe material was found to have high toughness under dynamic loading condition through the CT fracture toughness test. As the results of pipe fracture tests, the maximum moment to pipe fracture under dynamic monotonic and cyclic loading condition, could be estimated by plastic collapse criterion and the effect of dynamic monotonic loading and cyclic loading was a little on the maximum moment to pipe fracture of the STS410 carbon steel pipe. The STS410 carbon steel pipe seemed to be less sensitive to dynamic and cyclic loading effects than the A106Gr.B carbon steel pipe evaluated in IPIRG-1 program.

Effect of dynamic monotonic and cyclic loading on fracture behavior for Japanese carbon steel pipe STS410

International Nuclear Information System (INIS)

Kinoshita, Kanji; Murayama, Kouichi; Ogata, Hiroyuki

1997-01-01

The fracture behavior for Japanese carbon steel pipe STS410 was examined under dynamic monotonic and cyclic loading through a research program of International Piping Integrity Research Group (EPIRG-2), in order to evaluate the strength of pipe during the seismic event The tensile test and the fracture toughness test were conducted for base metal and TIG weld metal. Three base metal pipe specimens, 1,500mm in length and 6-inch diameter sch.120, were employed for a quasi-static monotonic, a dynamic monotonic and a dynamic cyclic loading pipe fracture tests. One weld joint pipe specimen was also employed for a dynamic cyclic loading test In the dynamic cyclic loading test, the displacement was controlled as applying the fully reversed load (R=-1). The pipe specimens with a circumferential through-wall crack were subjected four point bending load at 300C in air. Japanese STS410 carbon steel pipe material was found to have high toughness under dynamic loading condition through the CT fracture toughness test. As the results of pipe fracture tests, the maximum moment to pipe fracture under dynamic monotonic and cyclic loading condition, could be estimated by plastic collapse criterion and the effect of dynamic monotonic loading and cyclic loading was a little on the maximum moment to pipe fracture of the STS410 carbon steel pipe. The STS410 carbon steel pipe seemed to be less sensitive to dynamic and cyclic loading effects than the A106Gr.B carbon steel pipe evaluated in IPIRG-1 program

Stability properties of an anisotropic guiding center plasma and relation with the Suydam function

International Nuclear Information System (INIS)

Choe, J.Y.; Davidson, R.C.

1979-01-01

The effect of pressure anisotropy on the equilibrium and stability properties of an unstable guiding center plasma and the dependence of associated stability properties on the Suydam function S are examined. An explicit solution of the guiding center plasma equilibrium equation is obtained as a function of the anitsotropy parameter αequivalentP/sub parallel//P/sub perpendicular/ (assumed constant), and the maximum growth rates for internal kink modes are numerically computed for the entire permissible range of α. For a typical tokamak field configuration with shear in straight cylindrical geometry, it is found that the maximum growth rate is a monotonically increasing function of α. A detailed parameter study of equilibrium and stability properties is presented. The dependence of stability properties on the Suydam function S is investigated by correlating maximum growth rates with the magnitude of S, and by examining the ratio of consecutive eigenvalues for each set of the parameters. The numerical analysis shows that, even though the Suydam function occurs naturally in studies of marginal stability, the maximum growth rate (except for a narrow range of α) is a monotonically decreasing function of S

Multipartite entangled quantum states: Transformation, Entanglement monotones and Application

Science.gov (United States)

Cui, Wei

Entanglement is one of the fundamental features of quantum information science. Though bipartite entanglement has been analyzed thoroughly in theory and shown to be an important resource in quantum computation and communication protocols, the theory of entanglement shared between more than two parties, which is called multipartite entanglement, is still not complete. Specifically, the classification of multipartite entanglement and the transformation property between different multipartite states by local operators and classical communications (LOCC) are two fundamental questions in the theory of multipartite entanglement. In this thesis, we present results related to the LOCC transformation between multipartite entangled states. Firstly, we investigate the bounds on the LOCC transformation probability between multipartite states, especially the GHZ class states. By analyzing the involvement of 3-tangle and other entanglement measures under weak two-outcome measurement, we derive explicit upper and lower bound on the transformation probability between GHZ class states. After that, we also analyze the transformation between N-party W type states, which is a special class of multipartite entangled states that has an explicit unique expression and a set of analytical entanglement monotones. We present a necessary and sufficient condition for a known upper bound of transformation probability between two N-party W type states to be achieved. We also further investigate a novel entanglement transformation protocol, the random distillation, which transforms multipartite entanglement into bipartite entanglement ii shared by a non-deterministic pair of parties. We find upper bounds for the random distillation protocol for general N-party W type states and find the condition for the upper bounds to be achieved. What is surprising is that the upper bounds correspond to entanglement monotones that can be increased by Separable Operators (SEP), which gives the first set of

Hybrid Proximal-Point Methods for Zeros of Maximal Monotone Operators, Variational Inequalities and Mixed Equilibrium Problems

Directory of Open Access Journals (Sweden)

Kriengsak Wattanawitoon

2011-01-01

Full Text Available We prove strong and weak convergence theorems of modified hybrid proximal-point algorithms for finding a common element of the zero point of a maximal monotone operator, the set of solutions of equilibrium problems, and the set of solution of the variational inequality operators of an inverse strongly monotone in a Banach space under different conditions. Moreover, applications to complementarity problems are given. Our results modify and improve the recently announced ones by Li and Song (2008 and many authors.

Modeling non-monotonic properties under propositional argumentation

Science.gov (United States)

Wang, Geng; Lin, Zuoquan

2013-03-01

In the field of knowledge representation, argumentation is usually considered as an abstract framework for nonclassical logic. In this paper, however, we'd like to present a propositional argumentation framework, which can be used to closer simulate a real-world argumentation. We thereby argue that under a dialectical argumentation game, we can allow non-monotonic reasoning even under classical logic. We introduce two methods together for gaining nonmonotonicity, one by giving plausibility for arguments, the other by adding "exceptions" which is similar to defaults. Furthermore, we will give out an alternative definition for propositional argumentation using argumentative models, which is highly related to the previous reasoning method, but with a simple algorithm for calculation.

A Min-max Relation for Monotone Path Systems in Simple Regions

DEFF Research Database (Denmark)

Cameron, Kathleen

1996-01-01

A monotone path system (MPS) is a finite set of pairwise disjointpaths (polygonal arcs) in the plane such that every horizontal line intersectseach of the paths in at most one point. We consider a simple polygon in thexy-plane which bounds the simple polygonal (closed) region D. Let T and B betwo...

On a strong law of large numbers for monotone measures

Czech Academy of Sciences Publication Activity Database

Agahi, H.; Mohammadpour, A.; Mesiar, Radko; Ouyang, Y.

2013-01-01

Roč. 83, č. 4 (2013), s. 1213-1218 ISSN 0167-7152 R&D Projects: GA ČR GAP402/11/0378 Institutional support: RVO:67985556 Keywords : capacity * Choquet integral * strong law of large numbers Subject RIV: BA - General Mathematics Impact factor: 0.531, year: 2013 http://library.utia.cas.cz/separaty/2013/E/mesiar-on a strong law of large numbers for monotone measures.pdf

The Monotonic Lagrangian Grid for Rapid Air-Traffic Evaluation

Science.gov (United States)

Kaplan, Carolyn; Dahm, Johann; Oran, Elaine; Alexandrov, Natalia; Boris, Jay

2010-01-01

The Air Traffic Monotonic Lagrangian Grid (ATMLG) is presented as a tool to evaluate new air traffic system concepts. The model, based on an algorithm called the Monotonic Lagrangian Grid (MLG), can quickly sort, track, and update positions of many aircraft, both on the ground (at airports) and in the air. The underlying data structure is based on the MLG, which is used for sorting and ordering positions and other data needed to describe N moving bodies and their interactions. Aircraft that are close to each other in physical space are always near neighbors in the MLG data arrays, resulting in a fast nearest-neighbor interaction algorithm that scales as N. Recent upgrades to ATMLG include adding blank place-holders within the MLG data structure, which makes it possible to dynamically change the MLG size and also improves the quality of the MLG grid. Additional upgrades include adding FAA flight plan data, such as way-points and arrival and departure times from the Enhanced Traffic Management System (ETMS), and combining the MLG with the state-of-the-art strategic and tactical conflict detection and resolution algorithms from the NASA-developed Stratway software. In this paper, we present results from our early efforts to couple ATMLG with the Stratway software, and we demonstrate that it can be used to quickly simulate air traffic flow for a very large ETMS dataset.

A Mathematical Model for Non-monotonic Deposition Profiles in Deep Bed Filtration Systems

DEFF Research Database (Denmark)

Yuan, Hao; Shapiro, Alexander

2011-01-01

A mathematical model for suspension/colloid flow in porous media and non-monotonic deposition is proposed. It accounts for the migration of particles associated with the pore walls via the second energy minimum (surface associated phase). The surface associated phase migration is characterized...... by advection and diffusion/dispersion. The proposed model is able to produce a nonmonotonic deposition profile. A set of methods for estimating the modeling parameters is provided in the case of minimal particle release. The estimation can be easily performed with available experimental information....... The numerical modeling results highly agree with the experimental observations, which proves the ability of the model to catch a non-monotonic deposition profile in practice. An additional equation describing a mobile population behaving differently from the injected population seems to be a sufficient...

Non-monotonic wetting behavior of chitosan films induced by silver nanoparticles

Energy Technology Data Exchange (ETDEWEB)

Praxedes, A.P.P.; Webler, G.D.; Souza, S.T. [Instituto de Física, Universidade Federal de Alagoas, 57072-970 Maceió, AL (Brazil); Ribeiro, A.S. [Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, 57072-970 Maceió, AL (Brazil); Fonseca, E.J.S. [Instituto de Física, Universidade Federal de Alagoas, 57072-970 Maceió, AL (Brazil); Oliveira, I.N. de, E-mail: italo@fis.ufal.br [Instituto de Física, Universidade Federal de Alagoas, 57072-970 Maceió, AL (Brazil)

2016-05-01

Highlights: • The addition of silver nanoparticles modifies the morphology of chitosan films. • Metallic nanoparticles can be used to control wetting properties of chitosan films. • The contact angle shows a non-monotonic dependence on the silver concentration. - Abstract: The present work is devoted to the study of structural and wetting properties of chitosan-based films containing silver nanoparticles. In particular, the effects of silver concentration on the morphology of chitosan films are characterized by different techniques, such as atomic force microscopy (AFM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). By means of dynamic contact angle measurements, we study the modification on surface properties of chitosan-based films due to the addition of silver nanoparticles. The results are analyzed in the light of molecular-kinetic theory which describes the wetting phenomena in terms of statistical dynamics for the displacement of liquid molecules in a solid substrate. Our results show that the wetting properties of chitosan-based films are high sensitive to the fraction of silver nanoparticles, with the equilibrium contact angle exhibiting a non-monotonic behavior.

Non-Monotonic Spatial Reasoning with Answer Set Programming Modulo Theories

OpenAIRE

Wałęga, Przemysław Andrzej; Schultz, Carl; Bhatt, Mehul

2016-01-01

The systematic modelling of dynamic spatial systems is a key requirement in a wide range of application areas such as commonsense cognitive robotics, computer-aided architecture design, and dynamic geographic information systems. We present ASPMT(QS), a novel approach and fully-implemented prototype for non-monotonic spatial reasoning -a crucial requirement within dynamic spatial systems- based on Answer Set Programming Modulo Theories (ASPMT). ASPMT(QS) consists of a (qualitative) spatial re...

On the Monotonicity and Log-Convexity of a Four-Parameter Homogeneous Mean

Directory of Open Access Journals (Sweden)

Yang Zhen-Hang

2008-01-01

Full Text Available Abstract A four-parameter homogeneous mean is defined by another approach. The criterion of its monotonicity and logarithmically convexity is presented, and three refined chains of inequalities for two-parameter mean values are deduced which contain many new and classical inequalities for means.

Monotonic Set-Extended Prefix Rewriting and Verification of Recursive Ping-Pong Protocols

DEFF Research Database (Denmark)

Delzanno, Giorgio; Esparza, Javier; Srba, Jiri

2006-01-01

of messages) some verification problems become decidable. In particular we give an algorithm to decide control state reachability, a problem related to security properties like secrecy and authenticity. The proof is via a reduction to a new prefix rewriting model called Monotonic Set-extended Prefix rewriting...

An iterative method for nonlinear demiclosed monotone-type operators

International Nuclear Information System (INIS)

Chidume, C.E.

1991-01-01

It is proved that a well known fixed point iteration scheme which has been used for approximating solutions of certain nonlinear demiclosed monotone-type operator equations in Hilbert spaces remains applicable in real Banach spaces with property (U, α, m+1, m). These Banach spaces include the L p -spaces, p is an element of [2,∞]. An application of our results to the approximation of a solution of a certain linear operator equation in this general setting is also given. (author). 19 refs

Dispersion forces in a four-component density functional theory framework

OpenAIRE

Pilemalm, Robert

2009-01-01

The main purpose of this thesis is to implement the Gauss--Legendre quadrature for the dispersion coefficient. This has been done and can be now be made with different number of points. The calculations with this implementation has shown that the relativistic impact on helium, neon, argon and krypton is largest for krypton, that has the highest charge of its nucleus. It was also seen that the polarizability of neon as a function of the imaginary angular frequency decreases monotonically from ...

Using exogenous variables in testing for monotonic trends in hydrologic time series

Science.gov (United States)

Alley, William M.

1988-01-01

One approach that has been used in performing a nonparametric test for monotonic trend in a hydrologic time series consists of a two-stage analysis. First, a regression equation is estimated for the variable being tested as a function of an exogenous variable. A nonparametric trend test such as the Kendall test is then performed on the residuals from the equation. By analogy to stagewise regression and through Monte Carlo experiments, it is demonstrated that this approach will tend to underestimate the magnitude of the trend and to result in some loss in power as a result of ignoring the interaction between the exogenous variable and time. An alternative approach, referred to as the adjusted variable Kendall test, is demonstrated to generally have increased statistical power and to provide more reliable estimates of the trend slope. In addition, the utility of including an exogenous variable in a trend test is examined under selected conditions.

Effect of fiber fabric orientation on the flexural monotonic and fatigue behavior of 2D woven ceramic matrix composites

International Nuclear Information System (INIS)

Chawla, N.; Liaw, P.K.; Lara-Curzio, E.; Ferber, M.K.; Lowden, R.A.

2012-01-01

The effect of fiber fabric orientation, i.e., parallel to loading and perpendicular to the loading axis, on the monotonic and fatigue behavior of plain-weave fiber reinforced SiC matrix laminated composites was investigated. Two composite systems were studied: Nextel 312 (3M Corp.) reinforced SiC and Nicalon (Nippon Carbon Corp.) reinforced SiC, both fabricated by Forced Chemical Vapor Infiltration (FCVI). The behavior of both materials was investigated under monotonic and fatigue loading. Interlaminar and in-plane shear tests were conducted to further correlate shear properties with the effect of fabric orientation, with respect to the loading axis, on the orientation effects in bending. The underlying mechanisms, in monotonic and fatigue loading, were investigated through post-fracture examination using scanning electron microscopy (SEM).

Elucidating the Relations Between Monotonic and Fatigue Properties of Laser Powder Bed Fusion Stainless Steel 316L

Science.gov (United States)

Zhang, Meng; Sun, Chen-Nan; Zhang, Xiang; Goh, Phoi Chin; Wei, Jun; Li, Hua; Hardacre, David

2018-03-01

The laser powder bed fusion (L-PBF) technique builds parts with higher static strength than the conventional manufacturing processes through the formation of ultrafine grains. However, its fatigue endurance strength σ f does not match the increased monotonic tensile strength σ b. This work examines the monotonic and fatigue properties of as-built and heat-treated L-PBF stainless steel 316L. It was found that the general linear relation σ f = mσ b for describing conventional ferrous materials is not applicable to L-PBF parts because of the influence of porosity. Instead, the ductility parameter correlated linearly with fatigue strength and was proposed as the new fatigue assessment criterion for porous L-PBF parts. Annealed parts conformed to the strength-ductility trade-off. Fatigue resistance was reduced at short lives, but the effect was partially offset by the higher ductility such that comparing with an as-built part of equivalent monotonic strength, the heat-treated parts were more fatigue resistant.

Mechanisms of plastic deformation (cyclic and monotonous) of Inconel X750

International Nuclear Information System (INIS)

Randrianarivony, H.

1992-01-01

Plastic deformation mechanisms under cyclic or monotonous solicitations, are analysed in function of Inconel X750 initial macrostructure. Two heat treated Inconel (first one is treated at 1366 K one hour, air cooled, aged at 977 K 20 hours, and air cooled, the second alloy is aged at 1158 K 24 hours, air cooled, aged at 977 K 20 hours, and air cooled), are characterized respectively by a fine and uniform precipitation of the γ' phase (approximative formulae: Ni 3 (Al,Ti)), and by a bimodal distribution of γ' precipitates. In both alloys, dislocations pairs (characteristic of a shearing by antiphase wall creation) are observed, and the crossing mechanism of the γ' precipitates by creation of overstructure pile defects is the same. But, glissile loops dislocations are less numerous than dislocations pairs in the first alloy, involving denser bands structure for this alloy (dislocations loops are always observed around γ' precipitates). Some comportment explications of Inconel X750 in PWR medium are given. (A.B.). refs., figs., tabs

Effect of meal glycemic load and caffeine consumption on prolonged monotonous driving performance.

Science.gov (United States)

Bragg, Christopher; Desbrow, Ben; Hall, Susan; Irwin, Christopher

2017-11-01

Monotonous driving involves low levels of stimulation and high levels of repetition and is essentially an exercise in sustained attention and vigilance. The aim of this study was to determine the effects of consuming a high or low glycemic load meal on prolonged monotonous driving performance. The effect of consuming caffeine with a high glycemic load meal was also examined. Ten healthy, non-diabetic participants (7 males, age 51±7yrs, mean±SD) completed a repeated measures investigation involving 3 experimental trials. On separate occasions, participants were provided one of three treatments prior to undertaking a 90min computer-based simulated drive. The 3 treatment conditions involved consuming: (1) a low glycemic load meal+placebo capsules (LGL), (2) a high glycemic load meal+placebo capsules (HGL) and (3) a high glycemic load meal+caffeine capsules (3mgkg -1 body weight) (CAF). Measures of driving performance included lateral (standard deviation of lane position (SDLP), average lane position (AVLP), total number of lane crossings (LC)) and longitudinal (average speed (AVSP) and standard deviation of speed (SDSP)) vehicle control parameters. Blood glucose levels, plasma caffeine concentrations and subjective ratings of sleepiness, alertness, mood, hunger and simulator sickness were also collected throughout each trial. No difference in either lateral or longitudinal vehicle control parameters or subjective ratings were observed between HGL and LGL treatments. A significant reduction in SDLP (0.36±0.20m vs 0.41±0.19m, p=0.004) and LC (34.4±31.4 vs 56.7±31.5, p=0.018) was observed in the CAF trial compared to the HGL trial. However, no differences in AVLP, AVSP and SDSP or subjective ratings were detected between these two trials (p>0.05). Altering the glycemic load of a breakfast meal had no effect on measures of monotonous driving performance in non-diabetic adults. Individuals planning to undertake a prolonged monotonous drive following consumption of a

Robust Monotonically Convergent Iterative Learning Control for Discrete-Time Systems via Generalized KYP Lemma

Directory of Open Access Journals (Sweden)

Jian Ding

2014-01-01

Full Text Available This paper addresses the problem of P-type iterative learning control for a class of multiple-input multiple-output linear discrete-time systems, whose aim is to develop robust monotonically convergent control law design over a finite frequency range. It is shown that the 2 D iterative learning control processes can be taken as 1 D state space model regardless of relative degree. With the generalized Kalman-Yakubovich-Popov lemma applied, it is feasible to describe the monotonically convergent conditions with the help of linear matrix inequality technique and to develop formulas for the control gain matrices design. An extension to robust control law design against systems with structured and polytopic-type uncertainties is also considered. Two numerical examples are provided to validate the feasibility and effectiveness of the proposed method.

Asian Option Pricing with Monotonous Transaction Costs under Fractional Brownian Motion

Directory of Open Access Journals (Sweden)

Di Pan

2013-01-01

Full Text Available Geometric-average Asian option pricing model with monotonous transaction cost rate under fractional Brownian motion was established. The method of partial differential equations was used to solve this model and the analytical expressions of the Asian option value were obtained. The numerical experiments show that Hurst exponent of the fractional Brownian motion and transaction cost rate have a significant impact on the option value.

Some properties of the Catalan-Qi function related to the Catalan numbers.

Science.gov (United States)

Qi, Feng; Mahmoud, Mansour; Shi, Xiao-Ting; Liu, Fang-Fang

2016-01-01

In the paper, the authors find some properties of the Catalan numbers, the Catalan function, and the Catalan-Qi function which is a generalization of the Catalan numbers. Concretely speaking, the authors present a new expression, asymptotic expansions, integral representations, logarithmic convexity, complete monotonicity, minimality, logarithmically complete monotonicity, a generating function, and inequalities of the Catalan numbers, the Catalan function, and the Catalan-Qi function. As by-products, an exponential expansion and a double inequality for the ratio of two gamma functions are derived.

Optimization of nonlinear, non-Gaussian Bayesian filtering for diagnosis and prognosis of monotonic degradation processes

Science.gov (United States)

Corbetta, Matteo; Sbarufatti, Claudio; Giglio, Marco; Todd, Michael D.

2018-05-01

The present work critically analyzes the probabilistic definition of dynamic state-space models subject to Bayesian filters used for monitoring and predicting monotonic degradation processes. The study focuses on the selection of the random process, often called process noise, which is a key perturbation source in the evolution equation of particle filtering. Despite the large number of applications of particle filtering predicting structural degradation, the adequacy of the picked process noise has not been investigated. This paper reviews existing process noise models that are typically embedded in particle filters dedicated to monitoring and predicting structural damage caused by fatigue, which is monotonic in nature. The analysis emphasizes that existing formulations of the process noise can jeopardize the performance of the filter in terms of state estimation and remaining life prediction (i.e., damage prognosis). This paper subsequently proposes an optimal and unbiased process noise model and a list of requirements that the stochastic model must satisfy to guarantee high prognostic performance. These requirements are useful for future and further implementations of particle filtering for monotonic system dynamics. The validity of the new process noise formulation is assessed against experimental fatigue crack growth data from a full-scale aeronautical structure using dedicated performance metrics.

The resource theory of quantum reference frames: manipulations and monotones

International Nuclear Information System (INIS)

Gour, Gilad; Spekkens, Robert W

2008-01-01

Every restriction on quantum operations defines a resource theory, determining how quantum states that cannot be prepared under the restriction may be manipulated and used to circumvent the restriction. A superselection rule (SSR) is a restriction that arises through the lack of a classical reference frame and the states that circumvent it (the resource) are quantum reference frames. We consider the resource theories that arise from three types of SSRs, associated respectively with lacking: (i) a phase reference, (ii) a frame for chirality, and (iii) a frame for spatial orientation. Focusing on pure unipartite quantum states (and in some cases restricting our attention even further to subsets of these), we explore single-copy and asymptotic manipulations. In particular, we identify the necessary and sufficient conditions for a deterministic transformation between two resource states to be possible and, when these conditions are not met, the maximum probability with which the transformation can be achieved. We also determine when a particular transformation can be achieved reversibly in the limit of arbitrarily many copies and find the maximum rate of conversion. A comparison of the three resource theories demonstrates that the extent to which resources can be interconverted decreases as the strength of the restriction increases. Along the way, we introduce several measures of frameness and prove that these are monotonically non-increasing under various classes of operations that are permitted by the SSR

Psychophysiological responses to short-term cooling during a simulated monotonous driving task.

Science.gov (United States)

Schmidt, Elisabeth; Decke, Ralf; Rasshofer, Ralph; Bullinger, Angelika C

2017-07-01

For drivers on monotonous routes, cognitive fatigue causes discomfort and poses an important risk for traffic safety. Countermeasures against this type of fatigue are required and thermal stimulation is one intervention method. Surprisingly, there are hardly studies available to measure the effect of cooling while driving. Hence, to better understand the effect of short-term cooling on the perceived sleepiness of car drivers, a driving simulator study (n = 34) was conducted in which physiological and vehicular data during cooling and control conditions were compared. The evaluation of the study showed that cooling applied during a monotonous drive increased the alertness of the car driver. The sleepiness rankings were significantly lower for the cooling condition. Furthermore, the significant pupillary and electrodermal responses were physiological indicators for increased sympathetic activation. In addition, during cooling a better driving performance was observed. In conclusion, the study shows generally that cooling has a positive short-term effect on drivers' wakefulness; in detail, a cooling period of 3 min delivers best results. Copyright © 2017 Elsevier Ltd. All rights reserved.

Non-monotonic dose dependence of the Ge- and Ti-centres in quartz

International Nuclear Information System (INIS)

Woda, C.; Wagner, G.A.

2007-01-01

The dose response of the Ge- and Ti-centres in quartz is studied over a large dose range. After an initial signal increase in the low dose range, both defects show a pronounced decrease in signal intensities for high doses. The model by Euler and Kahan [1987. Radiation effects and anelastic loss in germanium-doped quartz. Phys. Rev. B 35 (9), 4351-4359], in which the signal drop is explained by an enhanced trapping of holes at the electron trapping site, is critically discussed. A generalization of the model is then developed, following similar considerations by Lawless et al. [2005. A model for non-monotonic dose dependence of thermoluminescence (TL). J. Phys. Condens. Matter 17, 737-753], who explained a signal drop in TL by an enhanced recombination rate with electrons at the recombination centre. Finally, an alternative model for the signal decay is given, based on the competition between single and double electron capture at the electron trapping site. From the critical discussion of the different models it is concluded that the double electron capture mechanism is the most probable effect for the dose response

Task-related signal decrease on functional magnetic resonance imaging

International Nuclear Information System (INIS)

Hara, Yoshie; Nakamura, Mitsugu; Tamaki, Norihiko; Tamura, Shogo; Kitamura, Junji

2001-01-01

An atypical pattern of signal change was identified on functional magnetic resonance (fMR) imaging in pathologic patients. Three normal volunteers and 34 patients with pathologic lesions near the primary motor cortex underwent fMR imaging with echo-planar imaging while performing a hand motor task. Signal intensities were evaluated with the z-score method, and the time course and changes of the signal intensity were calculated. Nine of the 34 patients with pathologic lesions displayed a significant task-related signal reduction in motor-related areas. They also presented a conventional task-related signal increase in other motor-related areas. The time courses of the increase and decrease were the inverse of each other. There was no significant difference between rates of signal increase and decrease. Our findings suggest that this atypical signal decrease is clinically significant, and that impaired vascular reactivity and altered oxygen metabolism could contribute to the task-related signal reduction. Brain areas showing such task-related signal decrease should be preserved at surgery. (author)

Non-monotonic behaviour in relaxation dynamics of image restoration

International Nuclear Information System (INIS)

Ozeki, Tomoko; Okada, Masato

2003-01-01

We have investigated the relaxation dynamics of image restoration through a Bayesian approach. The relaxation dynamics is much faster at zero temperature than at the Nishimori temperature where the pixel-wise error rate is minimized in equilibrium. At low temperature, we observed non-monotonic development of the overlap. We suggest that the optimal performance is realized through premature termination in the relaxation processes in the case of the infinite-range model. We also performed Markov chain Monte Carlo simulations to clarify the underlying mechanism of non-trivial behaviour at low temperature by checking the local field distributions of each pixel

Non-monotonic swelling of surface grafted hydrogels induced by pH and/or salt concentration

Science.gov (United States)

Longo, Gabriel S.; Olvera de la Cruz, Monica; Szleifer, I.

2014-09-01

We use a molecular theory to study the thermodynamics of a weak-polyacid hydrogel film that is chemically grafted to a solid surface. We investigate the response of the material to changes in the pH and salt concentration of the buffer solution. Our results show that the pH-triggered swelling of the hydrogel film has a non-monotonic dependence on the acidity of the bath solution. At most salt concentrations, the thickness of the hydrogel film presents a maximum when the pH of the solution is increased from acidic values. The quantitative details of such swelling behavior, which is not observed when the film is physically deposited on the surface, depend on the molecular architecture of the polymer network. This swelling-deswelling transition is the consequence of the complex interplay between the chemical free energy (acid-base equilibrium), the electrostatic repulsions between charged monomers, which are both modulated by the absorption of ions, and the ability of the polymer network to regulate charge and control its volume (molecular organization). In the absence of such competition, for example, for high salt concentrations, the film swells monotonically with increasing pH. A deswelling-swelling transition is similarly predicted as a function of the salt concentration at intermediate pH values. This reentrant behavior, which is due to the coupling between charge regulation and the two opposing effects triggered by salt concentration (screening electrostatic interactions and charging/discharging the acid groups), is similar to that found in end-grafted weak polyelectrolyte layers. Understanding how to control the response of the material to different stimuli, in terms of its molecular structure and local chemical composition, can help the targeted design of applications with extended functionality. We describe the response of the material to an applied pressure and an electric potential. We present profiles that outline the local chemical composition of the

The effect of pain on physical functioning after breast cancer treatment

DEFF Research Database (Denmark)

Andersen, Kenneth Geving; Christensen, Karl Bang; Kehlet, Henrik

2014-01-01

OBJECTIVES:: Persistent postsurgical pain, musculoskeletal pain, sensory disturbances and lymphedema are major clinical problems after treatment for breast cancer. However, there is little evidence on how these sequelae affects physical function. The aim was to develop and validate a procedure...... specific tool for assessing the impact of pain and other sequelae on physical function after breast cancer treatment. METHODS:: Literature review, patient and expert interviews were used to identify dimensions of physical function and sequelae. A questionnaire was developed and tested using cognitive......, lymphedema and other causes. Convergent validity was assessed using the "Quick-disability of arm, shoulder and hand" scale (Q-DASH). RESULTS:: About half of the patients reported decreased physical function. All 5 scales displayed good fit, unidimensionality, monotonicity, local independence, and lack...

Critical undrained shear strength of sand-silt mixtures under monotonic loading

Directory of Open Access Journals (Sweden)

Mohamed Bensoula

2014-07-01

Full Text Available This study uses experimental triaxial tests with monotonic loading to develop empirical relationships to estimate undrained critical shear strength. The effect of the fines content on undrained shear strength is analyzed for different density states. The parametric analysis indicates that, based on the soil void ratio and fine content properties, the undrained critical shear strength first increases and then decreases as the proportion of fines increases, which demonstrates the influence of fine content on a soil’s vulnerability to liquefaction. A series of monotonic undrained triaxial tests were performed on reconstituted saturated sand-silt mixtures. Beyond 30% fines content, a fraction of the silt participates in the soil’s skeleton chain force. In this context, the concept of the equivalent intergranular void ratio may be an appropriate parameter to express the critical shear strength of the studied soil. This parameter is able to control the undrained shear strength of non-plastic silt and sand mixtures with different densities.   Resumen Este estudio utiliza evaluaciones experimentales triaxiales con cargas repetitivas para desarrollar relaciones empíricas y estimar la tensión crítica de corte bajo condiciones no drenadas. El efecto de contenido de finos en la tensión de corte sin drenar se analizó en diferentes estados de densidad. El análisis paramétrico indica que, basado en la porosidad del suelo y las propiedades del material de finos, la tensión de corte sin drenar primero se incrementa y luego decrece mientras la proporción de finos aumenta, lo que demuestra la influencia de contenido de finos en la vulnerabilidad del suelo a la licuación. Una serie de las evaluaciones se realizó en  mezclas rehidratadas y saturadas de arena y cieno. Más allá del 30 % de los contenidos finos, una fracción del cieno hace parte principal de la cadena de fuerza del suelo. En este contexto, el concepto de porosidad equivalente

Non-monotonic probability of thermal reversal in thin-film biaxial nanomagnets with small energy barriers

Directory of Open Access Journals (Sweden)

N. Kani

2017-05-01

Full Text Available The goal of this paper is to investigate the short time-scale, thermally-induced probability of magnetization reversal for an biaxial nanomagnet that is characterized with a biaxial magnetic anisotropy. For the first time, we clearly show that for a given energy barrier of the nanomagnet, the magnetization reversal probability of an biaxial nanomagnet exhibits a non-monotonic dependence on its saturation magnetization. Specifically, there are two reasons for this non-monotonic behavior in rectangular thin-film nanomagnets that have a large perpendicular magnetic anisotropy. First, a large perpendicular anisotropy lowers the precessional period of the magnetization making it more likely to precess across the x^=0 plane if the magnetization energy exceeds the energy barrier. Second, the thermal-field torque at a particular energy increases as the magnitude of the perpendicular anisotropy increases during the magnetization precession. This non-monotonic behavior is most noticeable when analyzing the magnetization reversals on time-scales up to several tens of ns. In light of the several proposals of spintronic devices that require data retention on time-scales up to 10’s of ns, understanding the probability of magnetization reversal on the short time-scales is important. As such, the results presented in this paper will be helpful in quantifying the reliability and noise sensitivity of spintronic devices in which thermal noise is inevitably present.

Sufficient Descent Conjugate Gradient Methods for Solving Convex Constrained Nonlinear Monotone Equations

Directory of Open Access Journals (Sweden)

San-Yang Liu

2014-01-01

Full Text Available Two unified frameworks of some sufficient descent conjugate gradient methods are considered. Combined with the hyperplane projection method of Solodov and Svaiter, they are extended to solve convex constrained nonlinear monotone equations. Their global convergence is proven under some mild conditions. Numerical results illustrate that these methods are efficient and can be applied to solve large-scale nonsmooth equations.

Asymptotic estimates and exponential stability for higher-order monotone difference equations

Directory of Open Access Journals (Sweden)

Pituk Mihály

2005-01-01

Full Text Available Asymptotic estimates are established for higher-order scalar difference equations and inequalities the right-hand sides of which generate a monotone system with respect to the discrete exponential ordering. It is shown that in some cases the exponential estimates can be replaced with a more precise limit relation. As corollaries, a generalization of discrete Halanay-type inequalities and explicit sufficient conditions for the global exponential stability of the zero solution are given.

Asymptotic estimates and exponential stability for higher-order monotone difference equations

Directory of Open Access Journals (Sweden)

Mihály Pituk

2005-03-01

Full Text Available Asymptotic estimates are established for higher-order scalar difference equations and inequalities the right-hand sides of which generate a monotone system with respect to the discrete exponential ordering. It is shown that in some cases the exponential estimates can be replaced with a more precise limit relation. As corollaries, a generalization of discrete Halanay-type inequalities and explicit sufficient conditions for the global exponential stability of the zero solution are given.

Mapping axonal density and average diameter using non-monotonic time-dependent gradient-echo MRI

DEFF Research Database (Denmark)

Nunes, Daniel; Cruz, Tomás L; Jespersen, Sune N

2017-01-01

available in the clinic, or extremely long acquisition schemes to extract information from parameter-intensive models. In this study, we suggest that simple and time-efficient multi-gradient-echo (MGE) MRI can be used to extract the axon density from susceptibility-driven non-monotonic decay in the time...... the quantitative results are compared against ground-truth histology, they seem to reflect the axonal fraction (though with a bias, as evident from Bland-Altman analysis). As well, the extra-axonal fraction can be estimated. The results suggest that our model is oversimplified, yet at the same time evidencing......-dependent signal. We show, both theoretically and with simulations, that a non-monotonic signal decay will occur for multi-compartmental microstructures – such as axons and extra-axonal spaces, which we here used in a simple model for the microstructure – and that, for axons parallel to the main magnetic field...

Whole brain resting-state analysis reveals decreased functional connectivity in major depression

NARCIS (Netherlands)

Veer, I.M.; Beckmann, C.F.; van Tol, M.J.; Ferrarini, L.; Milles, J.; Veltman, D.J.; Aleman, A.; van Buchem, M.A.; van der Wee, N.J.; Rombouts, S.A.R.B.

2010-01-01

Recently, both increases and decreases in resting-state functional connectivity have been found in major depression. However, these studies only assessed functional connectivity within a specific network or between a few regions of interest, while comorbidity and use of medication was not always

The Cognitive Social Network in Dreams: Transitivity, Assortativity, and Giant Component Proportion Are Monotonic.

Science.gov (United States)

Han, Hye Joo; Schweickert, Richard; Xi, Zhuangzhuang; Viau-Quesnel, Charles

2016-04-01

For five individuals, a social network was constructed from a series of his or her dreams. Three important network measures were calculated for each network: transitivity, assortativity, and giant component proportion. These were monotonically related; over the five networks as transitivity increased, assortativity increased and giant component proportion decreased. The relations indicate that characters appear in dreams systematically. Systematicity likely arises from the dreamer's memory of people and their relations, which is from the dreamer's cognitive social network. But the dream social network is not a copy of the cognitive social network. Waking life social networks tend to have positive assortativity; that is, people tend to be connected to others with similar connectivity. Instead, in our sample of dream social networks assortativity is more often negative or near 0, as in online social networks. We show that if characters appear via a random walk, negative assortativity can result, particularly if the random walk is biased as suggested by remote associations. Copyright © 2015 Cognitive Science Society, Inc.

Inelastic behavior of materials and structures under monotonic and cyclic loading

CERN Document Server

Brünig, Michael

2015-01-01

This book presents studies on the inelastic behavior of materials and structures under monotonic and cyclic loads. It focuses on the description of new effects like purely thermal cycles or cases of non-trivial damages. The various models are based on different approaches and methods and scaling aspects are taken into account. In addition to purely phenomenological models, the book also presents mechanisms-based approaches. It includes contributions written by leading authors from a host of different countries.

Whole brain resting-state analysis reveals decreased functional connectivity in major depression

Directory of Open Access Journals (Sweden)

Ilya M. Veer

2010-09-01

Full Text Available Recently, both increases and decreases in resting-state functional connectivity have been found in major depression. However, these studies only assessed functional connectivity within a specific network or between a few regions of interest, while comorbidity and use of medication was not always controlled for. Therefore, the aim of the current study was to investigate whole-brain functional connectivity, unbiased by a priori definition of regions or networks of interest, in medication-free depressive patients without comorbidity. We analyzed resting-state fMRI data of 19 medication-free patients with a recent diagnosis of major depression (within six months before inclusion and no comorbidity, and 19 age- and gender-matched controls. Independent component analysis was employed on the concatenated data sets of all participants. Thirteen functionally relevant networks were identified, describing the entire study sample. Next, individual representations of the networks were created using a dual regression method. Statistical inference was subsequently done on these spatial maps using voxelwise permutation tests. Abnormal functional connectivity was found within three resting-state networks in depression: 1 decreased bilateral amygdala and left anterior insula connectivity in an affective network, 2 reduced connectivity of the left frontal pole in a network associated with attention and working memory, and 3 decreased bilateral lingual gyrus connectivity within ventromedial visual regions. None of these effects were associated with symptom severity or grey matter density. We found abnormal resting-state functional connectivity not previously associated with major depression, which might relate to abnormal affect regulation and mild cognitive deficits, both associated with the symptomatology of the disorder.

Hyperglycemia decreases mitochondrial function: The regulatory role of mitochondrial biogenesis

International Nuclear Information System (INIS)

Palmeira, Carlos M.; Rolo, Anabela P.; Berthiaume, Jessica; Bjork, James A.; Wallace, Kendall B.

2007-01-01

Increased generation of reactive oxygen species (ROS) is implicated in 'glucose toxicity' in diabetes. However, little is known about the action of glucose on the expression of transcription factors in hepatocytes, especially those involved in mitochondrial DNA (mtDNA) replication and transcription. Since mitochondrial functional capacity is dynamically regulated, we hypothesized that stressful conditions of hyperglycemia induce adaptations in the transcriptional control of cellular energy metabolism, including inhibition of mitochondrial biogenesis and oxidative metabolism. Cell viability, mitochondrial respiration, ROS generation and oxidized proteins were determined in HepG2 cells cultured in the presence of either 5.5 mM (control) or 30 mM glucose (high glucose) for 48 h, 96 h and 7 days. Additionally, mtDNA abundance, plasminogen activator inhibitor-1 (PAI-1), mitochondrial transcription factor A (TFAM) and nuclear respiratory factor-1 (NRF-1) transcripts were evaluated by real time PCR. High glucose induced a progressive increase in ROS generation and accumulation of oxidized proteins, with no changes in cell viability. Increased expression of PAI-1 was observed as early as 96 h of exposure to high glucose. After 7 days in hyperglycemia, HepG2 cells exhibited inhibited uncoupled respiration and decreased MitoTracker Red fluorescence associated with a 25% decrease in mtDNA and 16% decrease in TFAM transcripts. These results indicate that glucose may regulate mtDNA copy number by modulating the transcriptional activity of TFAM in response to hyperglycemia-induced ROS production. The decrease of mtDNA content and inhibition of mitochondrial function may be pathogenic hallmarks in the altered metabolic status associated with diabetes

Comparison of linear and non-linear monotonicity-based shape reconstruction using exact matrix characterizations

DEFF Research Database (Denmark)

Garde, Henrik

2018-01-01

. For a fair comparison, exact matrix characterizations are used when probing the monotonicity relations to avoid errors from numerical solution to PDEs and numerical integration. Using a special factorization of the Neumann-to-Dirichlet map also makes the non-linear method as fast as the linear method...

Height of the E layer as a function of solar activity

International Nuclear Information System (INIS)

Antonova, L.A.; Ivanov-Kholodnyj, G.S.; Zhivolup, T.G.

1992-01-01

Variations of h m E height of E layer maximum with solar activity are investigated using data of from rocket measurements. These data are contradictory ones and requires more exact definition. h m E decrease with growth of solar activity is predicted theoretically: small monotone decrease during solar cycle on the one hand, and/or jump-like decrease of h m E at a certain intermediate value of F 10.7 - on the other hand. New rather reliable results are obtained due to data from incoherent dissipation station. On the basis of these measurements it is obtained that at low and even at rather high solar activity there is a small monotone decrease of h m E, while at intermediate activity, when F 10.7 =140-180 there occurs more abrupt variation of h m E

Monotonic and Cyclic Behavior of DIN 34CrNiMo6 Tempered Alloy Steel

Directory of Open Access Journals (Sweden)

Ricardo Branco

2016-04-01

Full Text Available This paper aims at studying the monotonic and cyclic plastic deformation behavior of DIN 34CrNiMo6 high strength steel. Monotonic and low-cycle fatigue tests are conducted in ambient air, at room temperature, using standard 8-mm diameter specimens. The former tests are carried out under position control with constant displacement rate. The latter are performed under fully-reversed strain-controlled conditions, using the single-step test method, with strain amplitudes lying between ±0.4% and ±2.0%. After the tests, the fracture surfaces are examined by scanning electron microscopy in order to characterize the surface morphologies and identify the main failure mechanisms. Regardless of the strain amplitude, a softening behavior was observed throughout the entire life. Total strain energy density, defined as the sum of both tensile elastic and plastic strain energies, was revealed to be an adequate fatigue damage parameter for short and long lives.

On the Computation of Optimal Monotone Mean-Variance Portfolios via Truncated Quadratic Utility

OpenAIRE

Ales Cerný; Fabio Maccheroni; Massimo Marinacci; Aldo Rustichini

2008-01-01

We report a surprising link between optimal portfolios generated by a special type of variational preferences called divergence preferences (cf. [8]) and optimal portfolios generated by classical expected utility. As a special case we connect optimization of truncated quadratic utility (cf. [2]) to the optimal monotone mean-variance portfolios (cf. [9]), thus simplifying the computation of the latter.

Monotonic childhoods: representations of otherness in research writing

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Denise Marcos Bussoletti

2011-12-01

Full Text Available This paper is part of a doctoral thesis entitled “Monotonic childhoods – a rhapsody of hope”. It follows the perspective of a critical psychosocial and cultural study, and aims at discussing the other’s representation in research writing, electing childhood as an allegorical and refl ective place. It takes into consideration, by means of analysis, the drawings and poems of children from the Terezin ghetto during the Second World War. The work is mostly based on Serge Moscovici’s Social Representation Theory, but it is also in constant dialogue with other theories and knowledge fi elds, especially Walter Benjamin’s and Mikhail Bakhtin’s contributions. At the end, the paper supports the thesis that conceives poetics as one of the translation axes of childhood cultures.

A note on monotonically star Lindelöf spaces | Song | Quaestiones ...

African Journals Online (AJOL)

A space X is monotonically star Lindelöf if one assign to for each open cover U a subspace s(U) ⊆ X, called a kernel, such that s(U) is a Lindelöf subset of X, and st(s(U); U) = X, and if V renes U then ∪ s(U) ⊆ s(V), where st(s(U); U) = ∪ {U ∈ U : U ∩ s(U) ≠ ∅}. In this paper, we investigate the relationship between ...

ASPMT(QS): Non-Monotonic Spatial Reasoning with Answer Set Programming Modulo Theories

OpenAIRE

Wałęga, Przemysław Andrzej; Bhatt, Mehul; Schultz, Carl

2015-01-01

The systematic modelling of \\emph{dynamic spatial systems} [9] is a key requirement in a wide range of application areas such as comonsense cognitive robotics, computer-aided architecture design, dynamic geographic information systems. We present ASPMT(QS), a novel approach and fully-implemented prototype for non-monotonic spatial reasoning ---a crucial requirement within dynamic spatial systems-- based on Answer Set Programming Modulo Theories (ASPMT). ASPMT(QS) consists of a (qualitative) s...

Monotonicity Conditions for Multirate and Partitioned Explicit Runge-Kutta Schemes

KAUST Repository

Hundsdorfer, Willem

2013-01-01

Multirate schemes for conservation laws or convection-dominated problems seem to come in two flavors: schemes that are locally inconsistent, and schemes that lack mass-conservation. In this paper these two defects are discussed for one-dimensional conservation laws. Particular attention will be given to monotonicity properties of the multirate schemes, such as maximum principles and the total variation diminishing (TVD) property. The study of these properties will be done within the framework of partitioned Runge-Kutta methods. It will also be seen that the incompatibility of consistency and mass-conservation holds for ‘genuine’ multirate schemes, but not for general partitioned methods.

Semiparametric approach for non-monotone missing covariates in a parametric regression model

KAUST Repository

Sinha, Samiran

2014-02-26

Missing covariate data often arise in biomedical studies, and analysis of such data that ignores subjects with incomplete information may lead to inefficient and possibly biased estimates. A great deal of attention has been paid to handling a single missing covariate or a monotone pattern of missing data when the missingness mechanism is missing at random. In this article, we propose a semiparametric method for handling non-monotone patterns of missing data. The proposed method relies on the assumption that the missingness mechanism of a variable does not depend on the missing variable itself but may depend on the other missing variables. This mechanism is somewhat less general than the completely non-ignorable mechanism but is sometimes more flexible than the missing at random mechanism where the missingness mechansim is allowed to depend only on the completely observed variables. The proposed approach is robust to misspecification of the distribution of the missing covariates, and the proposed mechanism helps to nullify (or reduce) the problems due to non-identifiability that result from the non-ignorable missingness mechanism. The asymptotic properties of the proposed estimator are derived. Finite sample performance is assessed through simulation studies. Finally, for the purpose of illustration we analyze an endometrial cancer dataset and a hip fracture dataset.

ON AN EXPONENTIAL INEQUALITY AND A STRONG LAW OF LARGE NUMBERS FOR MONOTONE MEASURES

Czech Academy of Sciences Publication Activity Database

Agahi, H.; Mesiar, Radko

2014-01-01

Roč. 50, č. 5 (2014), s. 804-813 ISSN 0023-5954 Institutional support: RVO:67985556 Keywords : Choquet expectation * a strong law of large numbers * exponential inequality * monotone probability Subject RIV: BA - General Mathematics Impact factor: 0.541, year: 2014 http://library.utia.cas.cz/separaty/2014/E/mesiar-0438052.pdf

Decreased long- and short-range functional connectivity at rest in drug-naive major depressive disorder.

Science.gov (United States)

Guo, Wenbin; Liu, Feng; Chen, Jindong; Wu, Renrong; Zhang, Zhikun; Yu, Miaoyu; Xue, Zhimin; Zhao, Jingping

2016-08-01

Abnormal functional connectivity has been observed in major depressive disorder. Anatomical distance may affect functional connectivity in patients with major depressive disorder. However, whether and how anatomical distance affects functional connectivity at rest remains unclear in drug-naive patients with major depressive disorder. Forty-four patients with major depressive disorder, as well as 44 age-, sex- and education-matched healthy controls, underwent resting-state functional magnetic resonance imaging scanning. Regional functional connectivity strength was calculated for each voxel in the whole brain, which was further divided into short- and long-range functional connectivity strength. The patients showed decreased long-range positive functional connectivity strength in the right inferior parietal lobule, as well as decreased short-range positive functional connectivity strength in the right insula and right superior temporal gyrus relative to those of the controls. No significant correlations existed between abnormal functional connectivity strength and the clinical variables of the patients. The findings revealed that anatomical distance decreases long- and short-range functional connectivity strength in patients with major depressive disorder, which may underlie the neurobiology of major depressive disorder. © The Royal Australian and New Zealand College of Psychiatrists 2015.

Uniform persistence and upper Lyapunov exponents for monotone skew-product semiflows

International Nuclear Information System (INIS)

Novo, Sylvia; Obaya, Rafael; Sanz, Ana M

2013-01-01

Several results of uniform persistence above and below a minimal set of an abstract monotone skew-product semiflow are obtained. When the minimal set has a continuous separation the results are given in terms of the principal spectrum. In the case that the semiflow is generated by the solutions of a family of non-autonomous differential equations of ordinary, delay or parabolic type, the former results are strongly improved. A method of calculus of the upper Lyapunov exponent of the minimal set is also determined. (paper)

Complex, non-monotonic dose-response curves with multiple maxima: Do we (ever) sample densely enough?

Science.gov (United States)

Cvrčková, Fatima; Luštinec, Jiří; Žárský, Viktor

2015-01-01

We usually expect the dose-response curves of biological responses to quantifiable stimuli to be simple, either monotonic or exhibiting a single maximum or minimum. Deviations are often viewed as experimental noise. However, detailed measurements in plant primary tissue cultures (stem pith explants of kale and tobacco) exposed to varying doses of sucrose, cytokinins (BA or kinetin) or auxins (IAA or NAA) revealed that growth and several biochemical parameters exhibit multiple reproducible, statistically significant maxima over a wide range of exogenous substance concentrations. This results in complex, non-monotonic dose-response curves, reminiscent of previous reports of analogous observations in both metazoan and plant systems responding to diverse pharmacological treatments. These findings suggest the existence of a hitherto neglected class of biological phenomena resulting in dose-response curves exhibiting periodic patterns of maxima and minima, whose causes remain so far uncharacterized, partly due to insufficient sampling frequency used in many studies.

Decrease in pulmonary function and oxygenation after lung resection.

Science.gov (United States)

Brocki, Barbara Cristina; Westerdahl, Elisabeth; Langer, Daniel; Souza, Domingos S R; Andreasen, Jan Jesper

2018-01-01

Respiratory deficits are common following curative intent lung cancer surgery and may reduce the patient's ability to be physically active. We evaluated the influence of surgery on pulmonary function, respiratory muscle strength and physical performance after lung resection. Pulmonary function, respiratory muscle strength (maximal inspiratory/expiratory pressure) and 6-min walk test (6MWT) were assessed pre-operatively, 2 weeks post-operatively and 6 months post-operatively in 80 patients (age 68±9 years). Video-assisted thoracoscopic surgery was performed in 58% of cases. Two weeks post-operatively, we found a significant decline in pulmonary function (forced vital capacity -0.6±0.6 L and forced expiratory volume in 1 s -0.43±0.4 L; both p<0.0001), 6MWT (-37.6±74.8 m; p<0.0001) and oxygenation (-2.9±4.7 units; p<0.001), while maximal inspiratory and maximal expiratory pressure were unaffected. At 6 months post-operatively, pulmonary function and oxygenation remained significantly decreased (p<0.001), whereas 6MWT was recovered. We conclude that lung resection has a significant short- and long-term impact on pulmonary function and oxygenation, but not on respiratory muscle strength. Future research should focus on mechanisms negatively influencing post-operative pulmonary function other than impaired respiratory muscle strength.

Eigenvalue for Densely Defined Perturbations of Multivalued Maximal Monotone Operators in Reflexive Banach Spaces

Directory of Open Access Journals (Sweden)

Boubakari Ibrahimou

2013-01-01

maximal monotone with and . Using the topological degree theory developed by Kartsatos and Quarcoo we study the eigenvalue problem where the operator is a single-valued of class . The existence of continuous branches of eigenvectors of infinite length then could be easily extended to the case where the operator is multivalued and is investigated.

Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment

OpenAIRE

Lagarde, Fabien; Beausoleil, Claire; Belcher, Scott M; Belzunces, Luc P; Emond, Claude; Guerbet, Michel; Rousselle, Christophe

2015-01-01

International audience; Experimental studies investigating the effects of endocrine disruptors frequently identify potential unconventional dose-response relationships called non-monotonic dose-response (NMDR) relationships. Standardized approaches for investigating NMDR relationships in a risk assessment context are missing. The aim of this work was to develop criteria for assessing the strength of NMDR relationships. A literature search was conducted to identify published studies that repor...

Large Airborne Full Tensor Gradient Data Inversion Based on a Non-Monotone Gradient Method

Science.gov (United States)

Sun, Yong; Meng, Zhaohai; Li, Fengting

2018-03-01

Following the development of gravity gradiometer instrument technology, the full tensor gravity (FTG) data can be acquired on airborne and marine platforms. Large-scale geophysical data can be obtained using these methods, making such data sets a number of the "big data" category. Therefore, a fast and effective inversion method is developed to solve the large-scale FTG data inversion problem. Many algorithms are available to accelerate the FTG data inversion, such as conjugate gradient method. However, the conventional conjugate gradient method takes a long time to complete data processing. Thus, a fast and effective iterative algorithm is necessary to improve the utilization of FTG data. Generally, inversion processing is formulated by incorporating regularizing constraints, followed by the introduction of a non-monotone gradient-descent method to accelerate the convergence rate of FTG data inversion. Compared with the conventional gradient method, the steepest descent gradient algorithm, and the conjugate gradient algorithm, there are clear advantages of the non-monotone iterative gradient-descent algorithm. Simulated and field FTG data were applied to show the application value of this new fast inversion method.

The role of the indoor environment: Residential determinants of allergy, asthma and pulmonary function in children from a US-Mexico border community.

Science.gov (United States)

Svendsen, Erik R; Gonzales, Melissa; Commodore, Adwoa

2018-03-01

The El Paso Children's Health Study examined environmental risk factors for allergy and asthma among fourth and fifth grade schoolchildren living in a major United States-Mexico border city. Complete questionnaire information was available for 5210 children, while adequate pulmonary function data were available for a subset of 1874. Herein we studied indoor environmental health risk factors for allergy and asthma. Several indoor environmental risk factors were associated with allergy and asthma. In particular, we found that ant and spider pest problems, pet dogs, fireplace heat, central air conditioning, humidifier use, and cooking with gas stoves were positively associated with both allergy and asthma prevalence. With regards to asthma severity, our analysis indicated that exposure to pet dogs increased monotonically with increasing asthma severity while the lack of any heat source and gas stove use for cooking decreased monotonically with increasing asthma severity. Lung function also decreased among children who lived in homes with reported cockroach pest problem in the past year without concurrent use of pesticides. These effects on pulmonary function were present even after excluding children with a current physician's diagnosis of asthma. Clinicians and public health professionals may need to look closely at the contribution of these indoor risk factors on pulmonary health and quality of life among susceptible populations. Copyright © 2017 Elsevier B.V. All rights reserved.

The non-monotonic shear-thinning flow of two strongly cohesive concentrated suspensions

OpenAIRE

Buscall, Richard; Kusuma, Tiara E.; Stickland, Anthony D.; Rubasingha, Sayuri; Scales, Peter J.; Teo, Hui-En; Worrall, Graham L.

2014-01-01

The behaviour in simple shear of two concentrated and strongly cohesive mineral suspensions showing highly non-monotonic flow curves is described. Two rheometric test modes were employed, controlled stress and controlled shear-rate. In controlled stress mode the materials showed runaway flow above a yield stress, which, for one of the suspensions, varied substantially in value and seemingly at random from one run to the next, such that the up flow-curve appeared to be quite irreproducible. Th...

Assessing the Health of LiFePO4 Traction Batteries through Monotonic Echo State Networks

Science.gov (United States)

Anseán, David; Otero, José; Couso, Inés

2017-01-01

A soft sensor is presented that approximates certain health parameters of automotive rechargeable batteries from on-vehicle measurements of current and voltage. The sensor is based on a model of the open circuit voltage curve. This last model is implemented through monotonic neural networks and estimate over-potentials arising from the evolution in time of the Lithium concentration in the electrodes of the battery. The proposed soft sensor is able to exploit the information contained in operational records of the vehicle better than the alternatives, this being particularly true when the charge or discharge currents are between moderate and high. The accuracy of the neural model has been compared to different alternatives, including data-driven statistical models, first principle-based models, fuzzy observers and other recurrent neural networks with different topologies. It is concluded that monotonic echo state networks can outperform well established first-principle models. The algorithms have been validated with automotive Li-FePO4 cells. PMID:29267219

Assessing the Health of LiFePO4 Traction Batteries through Monotonic Echo State Networks

Directory of Open Access Journals (Sweden)

Luciano Sánchez

2017-12-01

Full Text Available A soft sensor is presented that approximates certain health parameters of automotive rechargeable batteries from on-vehicle measurements of current and voltage. The sensor is based on a model of the open circuit voltage curve. This last model is implemented through monotonic neural networks and estimate over-potentials arising from the evolution in time of the Lithium concentration in the electrodes of the battery. The proposed soft sensor is able to exploit the information contained in operational records of the vehicle better than the alternatives, this being particularly true when the charge or discharge currents are between moderate and high. The accuracy of the neural model has been compared to different alternatives, including data-driven statistical models, first principle-based models, fuzzy observers and other recurrent neural networks with different topologies. It is concluded that monotonic echo state networks can outperform well established first-principle models. The algorithms have been validated with automotive Li-FePO4 cells.

Monotone measures of ergodicity for Markov chains

Directory of Open Access Journals (Sweden)

J. Keilson

1998-01-01

Full Text Available The following paper, first written in 1974, was never published other than as part of an internal research series. Its lack of publication is unrelated to the merits of the paper and the paper is of current importance by virtue of its relation to the relaxation time. A systematic discussion is provided of the approach of a finite Markov chain to ergodicity by proving the monotonicity of an important set of norms, each measures of egodicity, whether or not time reversibility is present. The paper is of particular interest because the discussion of the relaxation time of a finite Markov chain [2] has only been clean for time reversible chains, a small subset of the chains of interest. This restriction is not present here. Indeed, a new relaxation time quoted quantifies the relaxation time for all finite ergodic chains (cf. the discussion of Q1(t below Equation (1.7]. This relaxation time was developed by Keilson with A. Roy in his thesis [6], yet to be published.

Decrease in pulmonary function and oxygenation after lung resection

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Barbara Cristina Brocki

2018-01-01

Full Text Available Respiratory deficits are common following curative intent lung cancer surgery and may reduce the patient's ability to be physically active. We evaluated the influence of surgery on pulmonary function, respiratory muscle strength and physical performance after lung resection. Pulmonary function, respiratory muscle strength (maximal inspiratory/expiratory pressure and 6-min walk test (6MWT were assessed pre-operatively, 2 weeks post-operatively and 6 months post-operatively in 80 patients (age 68±9 years. Video-assisted thoracoscopic surgery was performed in 58% of cases. Two weeks post-operatively, we found a significant decline in pulmonary function (forced vital capacity −0.6±0.6 L and forced expiratory volume in 1 s −0.43±0.4 L; both p<0.0001, 6MWT (−37.6±74.8 m; p<0.0001 and oxygenation (−2.9±4.7 units; p<0.001, while maximal inspiratory and maximal expiratory pressure were unaffected. At 6 months post-operatively, pulmonary function and oxygenation remained significantly decreased (p<0.001, whereas 6MWT was recovered. We conclude that lung resection has a significant short- and long-term impact on pulmonary function and oxygenation, but not on respiratory muscle strength. Future research should focus on mechanisms negatively influencing post-operative pulmonary function other than impaired respiratory muscle strength.

Eigenvalues, embeddings and generalised trigonometric functions

CERN Document Server

Lang, Jan

2011-01-01

The main theme of the book is the study, from the standpoint of s-numbers, of integral operators of Hardy type and related Sobolev embeddings. In the theory of s-numbers the idea is to attach to every bounded linear map between Banach spaces a monotone decreasing sequence of non-negative numbers with a view to the classification of operators according to the way in which these numbers approach a limit: approximation numbers provide an especially important example of such numbers. The asymptotic behavior of the s-numbers of Hardy operators acting between Lebesgue spaces is determined here in a wide variety of cases. The proof methods involve the geometry of Banach spaces and generalized trigonometric functions; there are connections with the theory of the p-Laplacian.

Effect of Pulse Polarity on Thresholds and on Non-monotonic Loudness Growth in Cochlear Implant Users.

Science.gov (United States)

Macherey, Olivier; Carlyon, Robert P; Chatron, Jacques; Roman, Stéphane

2017-06-01

Most cochlear implants (CIs) activate their electrodes non-simultaneously in order to eliminate electrical field interactions. However, the membrane of auditory nerve fibers needs time to return to its resting state, causing the probability of firing to a pulse to be affected by previous pulses. Here, we provide new evidence on the effect of pulse polarity and current level on these interactions. In experiment 1, detection thresholds and most comfortable levels (MCLs) were measured in CI users for 100-Hz pulse trains consisting of two consecutive biphasic pulses of the same or of opposite polarity. All combinations of polarities were studied: anodic-cathodic-anodic-cathodic (ACAC), CACA, ACCA, and CAAC. Thresholds were lower when the adjacent phases of the two pulses had the same polarity (ACCA and CAAC) than when they were different (ACAC and CACA). Some subjects showed a lower threshold for ACCA than for CAAC while others showed the opposite trend demonstrating that polarity sensitivity at threshold is genuine and subject- or electrode-dependent. In contrast, anodic (CAAC) pulses always showed a lower MCL than cathodic (ACCA) pulses, confirming previous reports. In experiments 2 and 3, the subjects compared the loudness of several pulse trains differing in current level separately for ACCA and CAAC. For 40 % of the electrodes tested, loudness grew non-monotonically as a function of current level for ACCA but never for CAAC. This finding may relate to a conduction block of the action potentials along the fibers induced by a strong hyperpolarization of their central processes. Further analysis showed that the electrodes showing a lower threshold for ACCA than for CAAC were more likely to yield a non-monotonic loudness growth. It is proposed that polarity sensitivity at threshold reflects the local neural health and that anodic asymmetric pulses should preferably be used to convey sound information while avoiding abnormal loudness percepts.

MONOTONIC DERIVATIVE CORRECTION FOR CALCULATION OF SUPERSONIC FLOWS WITH SHOCK WAVES

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P. V. Bulat

2015-07-01

Full Text Available Subject of Research. Numerical solution methods of gas dynamics problems based on exact and approximate solution of Riemann problem are considered. We have developed an approach to the solution of Euler equations describing flows of inviscid compressible gas based on finite volume method and finite difference schemes of various order of accuracy. Godunov scheme, Kolgan scheme, Roe scheme, Harten scheme and Chakravarthy-Osher scheme are used in calculations (order of accuracy of finite difference schemes varies from 1st to 3rd. Comparison of accuracy and efficiency of various finite difference schemes is demonstrated on the calculation example of inviscid compressible gas flow in Laval nozzle in the case of continuous acceleration of flow in the nozzle and in the case of nozzle shock wave presence. Conclusions about accuracy of various finite difference schemes and time required for calculations are made. Main Results. Comparative analysis of difference schemes for Euler equations integration has been carried out. These schemes are based on accurate and approximate solution for the problem of an arbitrary discontinuity breakdown. Calculation results show that monotonic derivative correction provides numerical solution uniformity in the breakdown neighbourhood. From the one hand, it prevents formation of new points of extremum, providing the monotonicity property, but from the other hand, causes smoothing of existing minimums and maximums and accuracy loss. Practical Relevance. Developed numerical calculation method gives the possibility to perform high accuracy calculations of flows with strong non-stationary shock and detonation waves. At the same time, there are no non-physical solution oscillations on the shock wave front.

Risk-Sensitive Control of Pure Jump Process on Countable Space with Near Monotone Cost

International Nuclear Information System (INIS)

Suresh Kumar, K.; Pal, Chandan

2013-01-01

In this article, we study risk-sensitive control problem with controlled continuous time pure jump process on a countable space as state dynamics. We prove multiplicative dynamic programming principle, elliptic and parabolic Harnack’s inequalities. Using the multiplicative dynamic programing principle and the Harnack’s inequalities, we prove the existence and a characterization of optimal risk-sensitive control under the near monotone condition

Iterative methods for nonlinear set-valued operators of the monotone type with applications to operator equations

International Nuclear Information System (INIS)

Chidume, C.E.

1989-06-01

The fixed points of set-valued operators satisfying a condition of monotonicity type in real Banach spaces with uniformly convex dual spaces are approximated by recursive averaging processes. Applications to important classes of linear and nonlinear operator equations are also presented. (author). 33 refs

The behavior of welded joint in steel pipe members under monotonic and cyclic loading

International Nuclear Information System (INIS)

Chang, Kyong-Ho; Jang, Gab-Chul; Shin, Young-Eui; Han, Jung-Guen; Kim, Jong-Min

2006-01-01

Most steel pipe members are joined by welding. The residual stress and weld metal in a welded joint have the influence on the behavior of steel pipes. Therefore, to accurately predict the behavior of steel pipes with a welded joint, the influence of welding residual stress and weld metal on the behavior of steel pipe must be investigated. In this paper, the residual stress of steel pipes with a welded joint was investigated by using a three-dimensional non-steady heat conduction analysis and a three-dimensional thermal elastic-plastic analysis. Based on the results of monotonic and cyclic loading tests, a hysteresis model for weld metal was formulated. The hysteresis model was proposed by the authors and applied to a three-dimensional finite elements analysis. To investigate the influence of a welded joint in steel pipes under monotonic and cyclic loading, three-dimensional finite elements analysis considering the proposed model and residual stress was carried out. The influence of a welded joint on the behavior of steel pipe members was investigated by comparing the analytical result both steel pipe with a welded joint and that without a welded joint

Multistability and gluing bifurcation to butterflies in coupled networks with non-monotonic feedback

International Nuclear Information System (INIS)

Ma Jianfu; Wu Jianhong

2009-01-01

Neural networks with a non-monotonic activation function have been proposed to increase their capacity for memory storage and retrieval, but there is still a lack of rigorous mathematical analysis and detailed discussions of the impact of time lag. Here we consider a two-neuron recurrent network. We first show how supercritical pitchfork bifurcations and a saddle-node bifurcation lead to the coexistence of multiple stable equilibria (multistability) in the instantaneous updating network. We then study the effect of time delay on the local stability of these equilibria and show that four equilibria lose their stability at a certain critical value of time delay, and Hopf bifurcations of these equilibria occur simultaneously, leading to multiple coexisting periodic orbits. We apply centre manifold theory and normal form theory to determine the direction of these Hopf bifurcations and the stability of bifurcated periodic orbits. Numerical simulations show very interesting global patterns of periodic solutions as the time delay is varied. In particular, we observe that these four periodic solutions are glued together along the stable and unstable manifolds of saddle points to develop a butterfly structure through a complicated process of gluing bifurcations of periodic solutions

A cascadic monotonic time-discretized algorithm for finite-level quantum control computation

Science.gov (United States)

Ditz, P.; Borzi`, A.

2008-03-01

A computer package (CNMS) is presented aimed at the solution of finite-level quantum optimal control problems. This package is based on a recently developed computational strategy known as monotonic schemes. Quantum optimal control problems arise in particular in quantum optics where the optimization of a control representing laser pulses is required. The purpose of the external control field is to channel the system's wavefunction between given states in its most efficient way. Physically motivated constraints, such as limited laser resources, are accommodated through appropriately chosen cost functionals. Program summaryProgram title: CNMS Catalogue identifier: ADEB_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADEB_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 770 No. of bytes in distributed program, including test data, etc.: 7098 Distribution format: tar.gz Programming language: MATLAB 6 Computer: AMD Athlon 64 × 2 Dual, 2:21 GHz, 1:5 GB RAM Operating system: Microsoft Windows XP Word size: 32 Classification: 4.9 Nature of problem: Quantum control Solution method: Iterative Running time: 60-600 sec

Construction of second order accurate monotone and stable residual distribution schemes for unsteady flow problems

International Nuclear Information System (INIS)

Abgrall, Remi; Mezine, Mohamed

2003-01-01

The aim of this paper is to construct upwind residual distribution schemes for the time accurate solution of hyperbolic conservation laws. To do so, we evaluate a space-time fluctuation based on a space-time approximation of the solution and develop new residual distribution schemes which are extensions of classical steady upwind residual distribution schemes. This method has been applied to the solution of scalar advection equation and to the solution of the compressible Euler equations both in two space dimensions. The first version of the scheme is shown to be, at least in its first order version, unconditionally energy stable and possibly conditionally monotonicity preserving. Using an idea of Csik et al. [Space-time residual distribution schemes for hyperbolic conservation laws, 15th AIAA Computational Fluid Dynamics Conference, Anahein, CA, USA, AIAA 2001-2617, June 2001], we modify the formulation to end up with a scheme that is unconditionally energy stable and unconditionally monotonicity preserving. Several numerical examples are shown to demonstrate the stability and accuracy of the method

MONOTONIC AND CYCLIC LOADING SIMULATION OF STRUCTURAL STEELWORK BEAM TO COLUMN BOLTED CONNECTIONS WITH CASTELLATED BEAM

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SAEID ZAHEDI VAHID

2013-08-01

Full Text Available Recently steel extended end plate connections are commonly used in rigid steel frame due to its good ductility and ability for energy dissipation. This connection system is recommended to be widely used in special moment-resisting frame subjected to vertical monotonic and cyclic loads. However improper design of beam to column connection can leads to collapses and fatalities. Therefore extensive study of beam to column connection design must be carried out, particularly when the connection is exposed to cyclic loadings. This paper presents a Finite Element Analysis (FEA approach as an alternative method in studying the behavior of such connections. The performance of castellated beam-column end plate connections up to failure was investigated subjected to monotonic and cyclic loading in vertical and horizontal direction. The study was carried out through a finite element analysis using the multi-purpose software package LUSAS. The effect of arranging the geometry and location of openings were also been investigated.

Sampling dynamics: an alternative to payoff-monotone selection dynamics

DEFF Research Database (Denmark)

Berkemer, Rainer

payoff-monotone nor payoff-positive which has interesting consequences. This can be demonstrated by application to the travelers dilemma, a deliberately constructed social dilemma. The game has just one symmetric Nash equilibrium which is Pareto inefficient. Especially when the travelers have many......'' of the standard game theory result. Both, analytical tools and agent based simulation are used to investigate the dynamic stability of sampling equilibria in a generalized travelers dilemma. Two parameters are of interest: the number of strategy options (m) available to each traveler and an experience parameter...... (k), which indicates the number of samples an agent would evaluate before fixing his decision. The special case (k=1) can be treated analytically. The stationary points of the dynamics must be sampling equilibria and one can calculate that for m>3 there will be an interior solution in addition...

Casimir force, excess free energy and C-function in O(n) systems with long-range interactions in the n → ∞ limit

International Nuclear Information System (INIS)

Chamati, H.; Dantchev, D.M.

2004-06-01

We present exact results on the behavior of the thermodynamic Casimir force and the excess free energy and the C-function in the framework of the d-dimensional spherical model with a power law long-range interaction decaying at large distances r as r -d- σ, where σ c , as well as for T > Tc and T c . The universal finite-size scaling function governing the behavior of the force in the critical region is derived and its asymptotics are investigated. While in the critical and under -d -d-, critical region the force is of the order of L -d , for T > T c it decays as L -dσ , where L is the thickness of the film. We consider both the case of a finite system that has no phase transition of its own, when d - σ when one observes a dimensional crossover from d to a d - 1 dimensional critical behavior. The behavior of the force along the phase coexistence line for a magnetic field H = 0 and T c . is also derived. We have proven analytically that the excess free energy is always negative ad monotonically increasing function of T and H, while the C-function is always non-negative and monotonically decreasing function of T and H. For the Casimir force we have demonstrated that for any σ > it is everywhere negative, i.e. an attraction between the surfaces bounding the system is to be observed. At T = T c the force is an increasing function of T for σ > 1 and a decreasing one for σ c is always achieved at some H ≠ 0 . (author)

Application of non-monotonic logic to failure diagnosis of nuclear power plant

International Nuclear Information System (INIS)

Takahashi, M.; Kitamura, M.; Sugiyama, K.

1989-01-01

A prototype diagnosis system for nuclear power plants was developed based on Truth Maintenance systems: TMS and Dempster-Shafer probability theory. The purpose of this paper is to establish basic technique for more intelligent, man-computer cooperative diagnosis system. The developed system is capable of carrying out the diagnostic inference under the imperfect observation condition with the help of the proposed belief revision procedure with TMS and the systematic uncertainty treatment with Dempster-Shafer theory. The usefulness and potentiality of the present non-monotonic logic were demonstrated through simulation experiments

Isochronous relaxation curves for type 304 stainless steel after monotonic and cyclic strain

International Nuclear Information System (INIS)

Swindeman, R.W.

1978-01-01

Relaxation tests to 100 hr were performed on type 304 stainless steel in the temperature range 480 to 650 0 C and were used to develop isochronous relaxation curves. Behavior after monotonic and cyclic strain was compared. Relaxation differed only slightly as a consequence of the type of previous strain, provided that plastic flow preceded the relaxation period. We observed that the short-time relaxation behavior did not manifest strong heat-to-heat variation in creep strength

APPLICATION OF A PRIMAL-DUAL INTERIOR POINT ALGORITHM USING EXACT SECOND ORDER INFORMATION WITH A NOVEL NON-MONOTONE LINE SEARCH METHOD TO GENERALLY CONSTRAINED MINIMAX OPTIMISATION PROBLEMS

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INTAN S. AHMAD

2008-04-01

Full Text Available This work presents the application of a primal-dual interior point method to minimax optimisation problems. The algorithm differs significantly from previous approaches as it involves a novel non-monotone line search procedure, which is based on the use of standard penalty methods as the merit function used for line search. The crucial novel concept is the discretisation of the penalty parameter used over a finite range of orders of magnitude and the provision of a memory list for each such order. An implementation within a logarithmic barrier algorithm for bounds handling is presented with capabilities for large scale application. Case studies presented demonstrate the capabilities of the proposed methodology, which relies on the reformulation of minimax models into standard nonlinear optimisation models. Some previously reported case studies from the open literature have been solved, and with significantly better optimal solutions identified. We believe that the nature of the non-monotone line search scheme allows the search procedure to escape from local minima, hence the encouraging results obtained.

Robust sampling-sourced numerical retrieval algorithm for optical energy loss function based on log–log mesh optimization and local monotonicity preserving Steffen spline

Energy Technology Data Exchange (ETDEWEB)

Maglevanny, I.I., E-mail: sianko@list.ru [Volgograd State Social Pedagogical University, 27 Lenin Avenue, Volgograd 400131 (Russian Federation); Smolar, V.A. [Volgograd State Technical University, 28 Lenin Avenue, Volgograd 400131 (Russian Federation)

2016-01-15

We introduce a new technique of interpolation of the energy-loss function (ELF) in solids sampled by empirical optical spectra. Finding appropriate interpolation methods for ELFs poses several challenges. The sampled ELFs are usually very heterogeneous, can originate from various sources thus so called “data gaps” can appear, and significant discontinuities and multiple high outliers can be present. As a result an interpolation based on those data may not perform well at predicting reasonable physical results. Reliable interpolation tools, suitable for ELF applications, should therefore satisfy several important demands: accuracy and predictive power, robustness and computational efficiency, and ease of use. We examined the effect on the fitting quality due to different interpolation schemes with emphasis on ELF mesh optimization procedures and we argue that the optimal fitting should be based on preliminary log–log scaling data transforms by which the non-uniformity of sampled data distribution may be considerably reduced. The transformed data are then interpolated by local monotonicity preserving Steffen spline. The result is a piece-wise smooth fitting curve with continuous first-order derivatives that passes through all data points without spurious oscillations. Local extrema can occur only at grid points where they are given by the data, but not in between two adjacent grid points. It is found that proposed technique gives the most accurate results and also that its computational time is short. Thus, it is feasible using this simple method to address practical problems associated with interaction between a bulk material and a moving electron. A compact C++ implementation of our algorithm is also presented.

Robust sampling-sourced numerical retrieval algorithm for optical energy loss function based on log–log mesh optimization and local monotonicity preserving Steffen spline

International Nuclear Information System (INIS)

Maglevanny, I.I.; Smolar, V.A.

2016-01-01

We introduce a new technique of interpolation of the energy-loss function (ELF) in solids sampled by empirical optical spectra. Finding appropriate interpolation methods for ELFs poses several challenges. The sampled ELFs are usually very heterogeneous, can originate from various sources thus so called “data gaps” can appear, and significant discontinuities and multiple high outliers can be present. As a result an interpolation based on those data may not perform well at predicting reasonable physical results. Reliable interpolation tools, suitable for ELF applications, should therefore satisfy several important demands: accuracy and predictive power, robustness and computational efficiency, and ease of use. We examined the effect on the fitting quality due to different interpolation schemes with emphasis on ELF mesh optimization procedures and we argue that the optimal fitting should be based on preliminary log–log scaling data transforms by which the non-uniformity of sampled data distribution may be considerably reduced. The transformed data are then interpolated by local monotonicity preserving Steffen spline. The result is a piece-wise smooth fitting curve with continuous first-order derivatives that passes through all data points without spurious oscillations. Local extrema can occur only at grid points where they are given by the data, but not in between two adjacent grid points. It is found that proposed technique gives the most accurate results and also that its computational time is short. Thus, it is feasible using this simple method to address practical problems associated with interaction between a bulk material and a moving electron. A compact C++ implementation of our algorithm is also presented.

Non-monotonicity and divergent time scale in Axelrod model dynamics

Science.gov (United States)

Vazquez, F.; Redner, S.

2007-04-01

We study the evolution of the Axelrod model for cultural diversity, a prototypical non-equilibrium process that exhibits rich dynamics and a dynamic phase transition between diversity and an inactive state. We consider a simple version of the model in which each individual possesses two features that can assume q possibilities. Within a mean-field description in which each individual has just a few interaction partners, we find a phase transition at a critical value qc between an active, diverse state for q < qc and a frozen state. For q lesssim qc, the density of active links is non-monotonic in time and the asymptotic approach to the steady state is controlled by a time scale that diverges as (q-qc)-1/2.

Renormalization in charged colloids: non-monotonic behaviour with the surface charge

International Nuclear Information System (INIS)

Haro-Perez, C; Quesada-Perez, M; Callejas-Fernandez, J; Schurtenberger, P; Hidalgo-Alvarez, R

2006-01-01

The static structure factor S(q) is measured for a set of deionized latex dispersions with different numbers of ionizable surface groups per particle and similar diameters. For a given volume fraction, the height of the main peak of S(q), which is a direct measure of the spatial ordering of latex particles, does not increase monotonically with the number of ionizable groups. This behaviour cannot be described using the classical renormalization scheme based on the cell model. We analyse our experimental data using a renormalization model based on the jellium approximation, which predicts the weakening of the spatial order for moderate and large particle charges. (letter to the editor)

Non-monotonic behavior of electron temperature in argon inductively coupled plasma and its analysis via novel electron mean energy equation

Science.gov (United States)

Zhao, Shu-Xia

2018-03-01

In this work, the behavior of electron temperature against the power in argon inductively coupled plasma is investigated by a fluid model. The model properly reproduces the non-monotonic variation of temperature with power observed in experiments. By means of a novel electron mean energy equation proposed for the first time in this article, this electron temperature behavior is interpreted. In the overall considered power range, the skin effect of radio frequency electric field results in localized deposited power density, responsible for an increase of electron temperature with power by means of one parameter defined as power density divided by electron density. At low powers, the rate fraction of multistep and Penning ionizations of metastables that consume electron energy two times significantly increases with power, which dominates over the skin effect and consequently leads to the decrease of temperature with power. In the middle power regime, a transition region of temperature is given by the competition between the ionizing effect of metastables and the skin effect of electric field. The power location where the temperature alters its trend moves to the low power end as increasing the pressure due to the lack of metastables. The non-monotonic curve of temperature is asymmetric at the short chamber due to the weak role of skin effect in increasing the temperature and tends symmetric when axially prolonging the chamber. Still, the validity of the fluid model in this prediction is estimated and the role of neutral gas heating is guessed. This finding is helpful for people understanding the different trends of temperature with power in the literature.

Reconstruing U-Shaped Functions

Science.gov (United States)

Werker, Janet F.; Hall, D. Geoffrey; Fais, Laurel

2004-01-01

U-shaped developmental functions, and their N-shaped cousins, have intrigued developmental psychologists for decades because they provide a compelling demonstration that development does not always entail a monotonic increase across age in a single underlying ability. Instead, the causes of development are much more complex. Indeed,…

Decreased Sudomotor Function is Involved in the Formation of Atopic Eczema in the Cubital Fossa

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Aya Takahashi

2013-01-01

Conclusions: These results suggest that decreased sweating is a major source of water in the stratum corneum, and decreased sudomotor function may be involved in both the cause and aggravation of representative atopic eczema in the cubital fossa.

Decrease of Fisher information and the information geometry of evolution equations for quantum mechanical probability amplitudes.

Science.gov (United States)

Cafaro, Carlo; Alsing, Paul M

2018-04-01

The relevance of the concept of Fisher information is increasing in both statistical physics and quantum computing. From a statistical mechanical standpoint, the application of Fisher information in the kinetic theory of gases is characterized by its decrease along the solutions of the Boltzmann equation for Maxwellian molecules in the two-dimensional case. From a quantum mechanical standpoint, the output state in Grover's quantum search algorithm follows a geodesic path obtained from the Fubini-Study metric on the manifold of Hilbert-space rays. Additionally, Grover's algorithm is specified by constant Fisher information. In this paper, we present an information geometric characterization of the oscillatory or monotonic behavior of statistically parametrized squared probability amplitudes originating from special functional forms of the Fisher information function: constant, exponential decay, and power-law decay. Furthermore, for each case, we compute both the computational speed and the availability loss of the corresponding physical processes by exploiting a convenient Riemannian geometrization of useful thermodynamical concepts. Finally, we briefly comment on the possibility of using the proposed methods of information geometry to help identify a suitable trade-off between speed and thermodynamic efficiency in quantum search algorithms.

Decrease of Fisher information and the information geometry of evolution equations for quantum mechanical probability amplitudes

Science.gov (United States)

Cafaro, Carlo; Alsing, Paul M.

2018-04-01

The relevance of the concept of Fisher information is increasing in both statistical physics and quantum computing. From a statistical mechanical standpoint, the application of Fisher information in the kinetic theory of gases is characterized by its decrease along the solutions of the Boltzmann equation for Maxwellian molecules in the two-dimensional case. From a quantum mechanical standpoint, the output state in Grover's quantum search algorithm follows a geodesic path obtained from the Fubini-Study metric on the manifold of Hilbert-space rays. Additionally, Grover's algorithm is specified by constant Fisher information. In this paper, we present an information geometric characterization of the oscillatory or monotonic behavior of statistically parametrized squared probability amplitudes originating from special functional forms of the Fisher information function: constant, exponential decay, and power-law decay. Furthermore, for each case, we compute both the computational speed and the availability loss of the corresponding physical processes by exploiting a convenient Riemannian geometrization of useful thermodynamical concepts. Finally, we briefly comment on the possibility of using the proposed methods of information geometry to help identify a suitable trade-off between speed and thermodynamic efficiency in quantum search algorithms.

Elucidation of the effects of cementite morphology on damage formation during monotonic and cyclic tension in binary low carbon steels using in situ characterization

Energy Technology Data Exchange (ETDEWEB)

Koyama, Motomichi, E-mail: koyama@mech.kyushu-u.ac.jp [Faculty of Engineering, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka-shi, Fukuoka 819-0395 (Japan); Yu, Yachen; Zhou, Jia-Xi [Faculty of Engineering, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka-shi, Fukuoka 819-0395 (Japan); Yoshimura, Nobuyuki [Nippon Steel & Sumitomo Metal Corporation, 20-1 Shintomi, Futtsu, Chiba 293-8511 (Japan); Sakurada, Eisaku [Nippon Steel & Sumitomo Metal Corporation, 5-3 Tokai, Aichi 476-8686 (Japan); Ushioda, Kohsaku [Nippon Steel & Sumitomo Metal Corporation, 20-1 Shintomi, Futtsu, Chiba 293-8511 (Japan); Noguchi, Hiroshi [Faculty of Engineering, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka-shi, Fukuoka 819-0395 (Japan)

2016-06-14

The effects of the morphology and distribution of cementite on damage formation were studied using in situ scanning electron microscopy under monotonic and cyclic tension. To investigate the effects of the morphology/distribution of cementite, intergranular cementite precipitation (ICP) and transgranular cementite precipitation (TCP) steels were prepared from an ingot of Fe-0.017 wt% C binary alloy using different heat treatments. In all cases, the damage incidents were observed primarily at the grain boundaries. The damage morphology was dependent on the cementite morphology and loading condition. Monotonic tension in the ICP steel caused cracks across the cementite plates, located at the grain boundaries. In contrast, fatigue loading in the ICP steel induced cracking at the ferrite/cementite interface. Moreover, in the TCP steel, monotonic tension- and cyclic tension-induced intergranular cracking was distinctly observed, due to the slip localization associated with a limited availability of free slip paths. When a notch is introduced to the ICP steel specimen, the morphology of the cyclic tension-induced damage at the notch tip changed to resemble that across the intergranular cementite, and was rather similar to the monotonic tension-induced damage. The damage at the notch tip coalesced with the main crack, accelerating the growth of the fatigue crack.

Use Residual Correction Method and Monotone Iterative Technique to Calculate the Upper and Lower Approximate Solutions of Singularly Perturbed Non-linear Boundary Value Problems

Directory of Open Access Journals (Sweden)

Chi-Chang Wang

2013-09-01

Full Text Available This paper seeks to use the proposed residual correction method in coordination with the monotone iterative technique to obtain upper and lower approximate solutions of singularly perturbed non-linear boundary value problems. First, the monotonicity of a non-linear differential equation is reinforced using the monotone iterative technique, then the cubic-spline method is applied to discretize and convert the differential equation into the mathematical programming problems of an inequation, and finally based on the residual correction concept, complex constraint solution problems are transformed into simpler questions of equational iteration. As verified by the four examples given in this paper, the method proposed hereof can be utilized to fast obtain the upper and lower solutions of questions of this kind, and to easily identify the error range between mean approximate solutions and exact solutions.

Relationship between cognitive function and prevalence of decrease in intrinsic academic motivation in adolescents

Science.gov (United States)

2011-01-01

Background Decrease in intrinsic motivation is a common complaint among elementary and junior high school students, and is related to poor academic performance. Since grade-dependent development of cognitive functions also influences academic performance by these students, we examined whether cognitive functions are related to the prevalence of decrease in intrinsic academic motivation. Methods The study group consisted of 134 elementary school students from 4th to 6th grades and 133 junior high school students from 7th to 9th grades. Participants completed a questionnaire on intrinsic academic motivation. They also performed paper-and-pencil and computerized cognitive tests to measure abilities in motor processing, spatial construction, semantic fluency, immediate memory, short-term memory, delayed memory, spatial working memory, and selective, alternative, and divided attention. Results In multivariate logistic regression analyses adjusted for grade and gender, scores of none of the cognitive tests were correlated with the prevalence of decrease in intrinsic academic motivation in elementary school students. However, low digit span forward test score and score for comprehension of the story in the kana pick-out test were positively correlated with the prevalence of decrease in intrinsic academic motivation in junior high school students. Conclusions The present findings suggest that decrease in capacity for verbal memory is associated with the prevalence of decrease in intrinsic academic motivation among junior high school students. PMID:21235802

Relationship between cognitive function and prevalence of decrease in intrinsic academic motivation in adolescents

Directory of Open Access Journals (Sweden)

Fukuda Sanae

2011-01-01

Full Text Available Abstract Background Decrease in intrinsic motivation is a common complaint among elementary and junior high school students, and is related to poor academic performance. Since grade-dependent development of cognitive functions also influences academic performance by these students, we examined whether cognitive functions are related to the prevalence of decrease in intrinsic academic motivation. Methods The study group consisted of 134 elementary school students from 4th to 6th grades and 133 junior high school students from 7th to 9th grades. Participants completed a questionnaire on intrinsic academic motivation. They also performed paper-and-pencil and computerized cognitive tests to measure abilities in motor processing, spatial construction, semantic fluency, immediate memory, short-term memory, delayed memory, spatial working memory, and selective, alternative, and divided attention. Results In multivariate logistic regression analyses adjusted for grade and gender, scores of none of the cognitive tests were correlated with the prevalence of decrease in intrinsic academic motivation in elementary school students. However, low digit span forward test score and score for comprehension of the story in the kana pick-out test were positively correlated with the prevalence of decrease in intrinsic academic motivation in junior high school students. Conclusions The present findings suggest that decrease in capacity for verbal memory is associated with the prevalence of decrease in intrinsic academic motivation among junior high school students.

Relationship between cognitive function and prevalence of decrease in intrinsic academic motivation in adolescents.

Science.gov (United States)

Mizuno, Kei; Tanaka, Masaaki; Fukuda, Sanae; Imai-Matsumura, Kyoko; Watanabe, Yasuyoshi

2011-01-14

Decrease in intrinsic motivation is a common complaint among elementary and junior high school students, and is related to poor academic performance. Since grade-dependent development of cognitive functions also influences academic performance by these students, we examined whether cognitive functions are related to the prevalence of decrease in intrinsic academic motivation. The study group consisted of 134 elementary school students from 4th to 6th grades and 133 junior high school students from 7th to 9th grades. Participants completed a questionnaire on intrinsic academic motivation. They also performed paper-and-pencil and computerized cognitive tests to measure abilities in motor processing, spatial construction, semantic fluency, immediate memory, short-term memory, delayed memory, spatial working memory, and selective, alternative, and divided attention. In multivariate logistic regression analyses adjusted for grade and gender, scores of none of the cognitive tests were correlated with the prevalence of decrease in intrinsic academic motivation in elementary school students. However, low digit span forward test score and score for comprehension of the story in the kana pick-out test were positively correlated with the prevalence of decrease in intrinsic academic motivation in junior high school students. The present findings suggest that decrease in capacity for verbal memory is associated with the prevalence of decrease in intrinsic academic motivation among junior high school students.

Post-error expression of speed and force while performing a simple, monotonous task with a haptic pen

NARCIS (Netherlands)

Bruns, M.; Keyson, D.V.; Jabon, M.E.; Hummels, C.C.M.; Hekkert, P.P.M.; Bailenson, J.N.

2013-01-01

Control errors often occur in repetitive and monotonous tasks, such as manual assembly tasks. Much research has been done in the area of human error identification; however, most existing systems focus solely on the prediction of errors, not on increasing worker accuracy. The current study examines

Cytotoxicity of binary mixtures of human pharmaceuticals in a fish cell line: approaches for non-monotonic concentration-response relationships.

Science.gov (United States)

Bain, Peter A; Kumar, Anupama

2014-08-01

Predicting the effects of mixtures of environmental micropollutants is a priority research area. In this study, the cytotoxicity of ten pharmaceuticals to the rainbow trout cell line RTG-2 was determined using the neutral red uptake assay. Fluoxetine (FL), propranolol (PPN), and diclofenac (DCF) were selected for further study as binary mixtures. Biphasic concentration-response relationships were observed in cells exposed to FL and PPN. In the case of PPN, microscopic examination revealed lysosomal swelling indicative of direct uptake and accumulation of the compound. Three equations describing non-monotonic concentration-response relationships were evaluated and one was found to consistently provide more accurate estimates of the median and 10% effect concentrations compared with a sigmoidal concentration-response model. Predictive modeling of the effects of binary mixtures of FL, PPN, and DCF was undertaken using an implementation of the concentration addition (CA) conceptual model incorporating non-monotonic concentration-response relationships. The cytotoxicity of the all three binary combinations could be adequately predicted using CA, suggesting that the toxic mode of action in RTG-2 cells is unrelated to the therapeutic mode of action of these compounds. The approach presented here is widely applicable to the study of mixture toxicity in cases where non-monotonic concentration-response relationships are observed. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

A study on the evolution of dielectric function of ZnO thin films with decreasing film thickness

International Nuclear Information System (INIS)

Li, X. D.; Chen, T. P.; Liu, P.; Liu, Y.; Liu, Z.; Leong, K. C.

2014-01-01

Dielectric function, band gap, and exciton binding energies of ultrathin ZnO films as a function of film thickness have been obtained with spectroscopic ellipsometry. As the film thickness decreases, both real (ε 1 ) and imaginary (ε 2 ) parts of the dielectric function decrease significantly, and ε 2 shows a blue shift. The film thickness dependence of the dielectric function is shown related to the changes in the interband absorption, discrete-exciton absorption, and continuum-exciton absorption, which can be attributed to the quantum confinement effect on both the band gap and exciton binding energies

Maximum Likelihood, Consistency and Data Envelopment Analysis: A Statistical Foundation

OpenAIRE

Rajiv D. Banker

1993-01-01

This paper provides a formal statistical basis for the efficiency evaluation techniques of data envelopment analysis (DEA). DEA estimators of the best practice monotone increasing and concave production function are shown to be also maximum likelihood estimators if the deviation of actual output from the efficient output is regarded as a stochastic variable with a monotone decreasing probability density function. While the best practice frontier estimator is biased below the theoretical front...

Convex analysis and monotone operator theory in Hilbert spaces

CERN Document Server

Bauschke, Heinz H

2017-01-01

This reference text, now in its second edition, offers a modern unifying presentation of three basic areas of nonlinear analysis: convex analysis, monotone operator theory, and the fixed point theory of nonexpansive operators. Taking a unique comprehensive approach, the theory is developed from the ground up, with the rich connections and interactions between the areas as the central focus, and it is illustrated by a large number of examples. The Hilbert space setting of the material offers a wide range of applications while avoiding the technical difficulties of general Banach spaces. The authors have also drawn upon recent advances and modern tools to simplify the proofs of key results making the book more accessible to a broader range of scholars and users. Combining a strong emphasis on applications with exceptionally lucid writing and an abundance of exercises, this text is of great value to a large audience including pure and applied mathematicians as well as researchers in engineering, data science, ma...

Decreased serum level of NGF in alcohol-dependent patients with declined executive function

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Bae H

2014-11-01

Full Text Available Hwallip Bae,1 Youngsun Ra,1 Changwoo Han,2 Dai-Jin Kim3 1Department of Psychiatry, Myongji Hospital, Goyang, 2Department of Psychiatry, Keyo Hospital, Uiwang, 3Department of Psychiatry, Seoul St Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, South Korea Abstract: The role of neurotrophic factors has been highlighted as a cause of decline in the cognitive function of alcohol-dependent patients. It is known that nerve-growth factor (NGF, one of the neurotrophins, is related to the growth and differentiation of nerve cells, as well as to a decline in cognitive function. The purpose of this study was to investigate the relationship between decreased NGF levels and cognitive decline in alcohol-dependent patients. The serum concentration of NGF was measured in 38 patients with chronic alcohol dependence, and several neuropsychological tests were also performed for cognitive function assessment. The results indicated a significant correlation between serum NGF level and the trail-making test part B, which evaluates executive function, but did not show a significant correlation with other cognitive function tests. An increased serum level of NGF was associated with a decreased completion time in the trail-making test B, and this finding indicates that a high serum level of NGF is related to greater executive function. This finding may imply a protective role of NGF in preventing neuron damage among patients with alcohol dependence. Larger controlled studies will be necessary in the future to investigate this issue further. Keywords: nerve-growth factor, alcohol dependence, executive function, trail-making test

Decreased proteasomal function accelerates cigarette smoke-induced pulmonary emphysema in mice.

Science.gov (United States)

Yamada, Yosuke; Tomaru, Utano; Ishizu, Akihiro; Ito, Tomoki; Kiuchi, Takayuki; Ono, Ayako; Miyajima, Syota; Nagai, Katsura; Higashi, Tsunehito; Matsuno, Yoshihiro; Dosaka-Akita, Hirotoshi; Nishimura, Masaharu; Miwa, Soichi; Kasahara, Masanori

2015-06-01

Chronic obstructive pulmonary disease (COPD) is a disease common in elderly people, characterized by progressive destruction of lung parenchyma and chronic inflammation of the airways. The pathogenesis of COPD remains unclear, but recent studies suggest that oxidative stress-induced apoptosis in alveolar cells contributes to emphysematous lung destruction. The proteasome is a multicatalytic enzyme complex that plays a critical role in proteostasis by rapidly destroying misfolded and modified proteins generated by oxidative and other stresses. Proteasome activity decreases with aging in many organs including lungs, and an age-related decline in proteasomal function has been implicated in various age-related pathologies. However, the role of the proteasome system in the pathogenesis of COPD has not been investigated. Recently, we have established a transgenic (Tg) mouse model with decreased proteasomal chymotrypsin-like activity, showing age-related phenotypes. Using this model, we demonstrate here that decreased proteasomal function accelerates cigarette smoke (CS)-induced pulmonary emphysema. CS-exposed Tg mice showed remarkable airspace enlargement and increased foci of inflammation compared with wild-type controls. Importantly, apoptotic cells were found in the alveolar walls of the affected lungs. Impaired proteasomal activity also enhanced apoptosis in cigarette smoke extract (CSE)-exposed fibroblastic cells derived from mice and humans in vitro. Notably, aggresome formation and prominent nuclear translocation of apoptosis-inducing factor were observed in CSE-exposed fibroblastic cells isolated from Tg mice. Collective evidence suggests that CS exposure and impaired proteasomal activity coordinately enhance apoptotic cell death in the alveolar walls that may be involved in the development and progression of emphysema in susceptible individuals such as the elderly.

A Lattice-Misfit-Dependent Damage Model for Non-linear Damage Accumulations Under Monotonous Creep in Single Crystal Superalloys

Science.gov (United States)

le Graverend, J.-B.

2018-05-01

A lattice-misfit-dependent damage density function is developed to predict the non-linear accumulation of damage when a thermal jump from 1050 °C to 1200 °C is introduced somewhere in the creep life. Furthermore, a phenomenological model aimed at describing the evolution of the constrained lattice misfit during monotonous creep load is also formulated. The response of the lattice-misfit-dependent plasticity-coupled damage model is compared with the experimental results obtained at 140 and 160 MPa on the first generation Ni-based single crystal superalloy MC2. The comparison reveals that the damage model is well suited at 160 MPa and less at 140 MPa because the transfer of stress to the γ' phase occurs for stresses above 150 MPa which leads to larger variations and, therefore, larger effects of the constrained lattice misfit on the lifetime during thermo-mechanical loading.

NONSTANDARD PROBLEMS IN STUDYING THE PROPERTIES FUNCTIONS.

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V. I. Kuzmich

2010-06-01

Full Text Available In this paper we consider two non-standard problems that may be offered to students for independent solution in the study of fundamental properties of functions in the course of mathematical analysis. These tasks are wearing creativity and contribute to a better understanding of students to concepts such as monotonicity and continuity of the function.

Tur\\'an type inequalities for regular Coulomb wave functions

OpenAIRE

Baricz, Árpád

2015-01-01

Tur\\'an, Mitrinovi\\'c-Adamovi\\'c and Wilker type inequalities are deduced for regular Coulomb wave functions. The proofs are based on a Mittag-Leffler expansion for the regular Coulomb wave function, which may be of independent interest. Moreover, some complete monotonicity results concerning the Coulomb zeta functions and some interlacing properties of the zeros of Coulomb wave functions are given.

Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma.

Science.gov (United States)

Guilbert, Theresa W; Singh, Anne Marie; Danov, Zoran; Evans, Michael D; Jackson, Daniel J; Burton, Ryan; Roberg, Kathy A; Anderson, Elizabeth L; Pappas, Tressa E; Gangnon, Ronald; Gern, James E; Lemanske, Robert F

2011-09-01

Preschool rhinovirus (RV) wheezing illnesses predict an increased risk of childhood asthma; however, it is not clear how specific viral illnesses in early life relate to lung function later on in childhood. To determine the relationship of virus-specific wheezing illnesses and lung function in a longitudinal cohort of children at risk for asthma. Two hundred thirty-eight children were followed prospectively from birth to 8 years of age. Early life viral wheezing respiratory illnesses were assessed by using standard techniques, and lung function was assessed annually by using spirometry and impulse oscillometry. The relationships of these virus-specific wheezing illnesses and lung function were assessed by using mixed-effect linear regression. Children with RV wheezing illness demonstrated significantly decreased spirometry values, FEV(1) (P = .001), FEV(0.5) (P Children who wheezed with respiratory syncytial virus or other viral illnesses did not have any significant differences in spirometric or impulse oscillometry indices when compared with children who did not. Children diagnosed with asthma at ages 6 or 8 years had significantly decreased FEF(25-75) (P = .05) compared with children without asthma. Among outpatient viral wheezing illnesses in early childhood, those caused by RV infections are the most significant predictors of decreased lung function up to age 8 years in a high-risk birth cohort. Whether low lung function is a cause and/or effect of RV wheezing illnesses is yet to be determined. Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

Canonical single field slow-roll inflation with a non-monotonic tensor-to-scalar ratio

Energy Technology Data Exchange (ETDEWEB)

Germán, Gabriel [Rudolf Peierls Centre for Theoretical Physics, University of Oxford, 1 Keble Road, Oxford, OX1 3NP (United Kingdom); Herrera-Aguilar, Alfredo [Instituto de Física, Benemérita Universidad Autónoma de Puebla, Apdo. postal J-48, CP 72570, Puebla, Pue., México (Mexico); Hidalgo, Juan Carlos [Instituto de Ciencias Físicas, Universidad Nacional Autónoma de México, Apdo. postal 48-3, 62251 Cuernavaca, Morelos, México (Mexico); Sussman, Roberto A., E-mail: gabriel@fis.unam.mx, E-mail: aherrera@ifuap.buap.mx, E-mail: hidalgo@fis.unam.mx, E-mail: sussman@nucleares.unam.mx [Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Apdo. postal 70-543, 04510 México D. F., México (Mexico)

2016-05-01

We take a pragmatic, model independent approach to single field slow-roll canonical inflation by imposing conditions, not on the potential, but on the slow-roll parameter ε(φ) and its derivatives ε'(φ) and ε''(φ), thereby extracting general conditions on the tensor-to-scalar ratio r and the running n {sub sk} at φ {sub H} where the perturbations are produced, some 50–60 e -folds before the end of inflation. We find quite generally that for models where ε(φ) develops a maximum, a relatively large r is most likely accompanied by a positive running while a negligible tensor-to-scalar ratio implies negative running. The definitive answer, however, is given in terms of the slow-roll parameter ξ{sub 2}(φ). To accommodate a large tensor-to-scalar ratio that meets the limiting values allowed by the Planck data, we study a non-monotonic ε(φ) decreasing during most part of inflation. Since at φ {sub H} the slow-roll parameter ε(φ) is increasing, we thus require that ε(φ) develops a maximum for φ > φ {sub H} after which ε(φ) decrease to small values where most e -folds are produced. The end of inflation might occur trough a hybrid mechanism and a small field excursion Δφ {sub e} ≡ |φ {sub H} −φ {sub e} | is obtained with a sufficiently thin profile for ε(φ) which, however, should not conflict with the second slow-roll parameter η(φ). As a consequence of this analysis we find bounds for Δφ {sub e} , r {sub H} and for the scalar spectral index n {sub sH} . Finally we provide examples where these considerations are explicitly realised.

Functional Capillary Density Decreases after the First Week of Life in Term Neonates

NARCIS (Netherlands)

Top, A. P. C.; van Dijk, M.; van Velzen, J. E.; Ince, C.; Tibboel, D.

2010-01-01

Background: Changes in the microcirculation have been recognized to play a crucial role in many disease processes. In premature neonates, functional capillary density (FCD) decreases during the first months of life. Objectives: The aims of this study were to obtain microcirculatory parameters in

Functional capillary density decreases after the first week of life in term neonates

NARCIS (Netherlands)

A.P.C. Top (Anke); M. van Dijk (Monique); J.E. van Velzen; C. Ince (Can); D. Tibboel (Dick)

2010-01-01

textabstractBackground: Changes in the microcirculation have been recognized to play a crucial role in many disease processes. In premature neonates, functional capillary density (FCD) decreases during the first months of life. Objectives: The aims of this study were to obtain microcirculatory

Subtractive, divisive and non-monotonic gain control in feedforward nets linearized by noise and delays.

Science.gov (United States)

Mejias, Jorge F; Payeur, Alexandre; Selin, Erik; Maler, Leonard; Longtin, André

2014-01-01

The control of input-to-output mappings, or gain control, is one of the main strategies used by neural networks for the processing and gating of information. Using a spiking neural network model, we studied the gain control induced by a form of inhibitory feedforward circuitry-also known as "open-loop feedback"-, which has been experimentally observed in a cerebellum-like structure in weakly electric fish. We found, both analytically and numerically, that this network displays three different regimes of gain control: subtractive, divisive, and non-monotonic. Subtractive gain control was obtained when noise is very low in the network. Also, it was possible to change from divisive to non-monotonic gain control by simply modulating the strength of the feedforward inhibition, which may be achieved via long-term synaptic plasticity. The particular case of divisive gain control has been previously observed in vivo in weakly electric fish. These gain control regimes were robust to the presence of temporal delays in the inhibitory feedforward pathway, which were found to linearize the input-to-output mappings (or f-I curves) via a novel variability-increasing mechanism. Our findings highlight the feedforward-induced gain control analyzed here as a highly versatile mechanism of information gating in the brain.

Subtractive, divisive and non-monotonic gain control in feedforward nets linearized by noise and delays

Directory of Open Access Journals (Sweden)

Jorge F Mejias

2014-02-01

Full Text Available The control of input-to-output mappings, or gain control, is one of the main strategies used by neural networks for the processing and gating of information. Using a spiking neural network model, we studied the gain control induced by a form of inhibitory feedforward circuitry — also known as ’open-loop feedback’ —, which has been experimentally observed in a cerebellum-like structure in weakly electric fish. We found, both analytically and numerically, that this network displays three different regimes of gain control: subtractive, divisive, and non-monotonic. Subtractive gain control was obtained when noise is very low in the network. Also, it was possible to change from divisive to non-monotonic gain control by simply modulating the strength of the feedforward inhibition, which may be achieved via long-term synaptic plasticity. The particular case of divisive gain control has been previously observed in vivo in weakly electric fish. These gain control regimes were robust to the presence of temporal delays in the inhibitory feedforward pathway, which were found to linearize the input-to-output mappings (or f-I curves via a novel variability-increasing mechanism. Our findings highlight the feedforward-induced gain control analyzed here as a highly versatile mechanism of information gating in the brain.

Estrogen inhibits lysyl oxidase and decreases mechanical function in engineered ligaments.

Science.gov (United States)

Lee, Cassandra A; Lee-Barthel, Ann; Marquino, Louise; Sandoval, Natalie; Marcotte, George R; Baar, Keith

2015-05-15

Women are more likely to suffer an anterior cruciate ligament (ACL) rupture than men, and the incidence of ACL rupture in women rises with increasing estrogen levels. We used an engineered ligament model to determine how an acute rise in estrogen decreases the mechanical properties of ligaments. Using fibroblasts isolated from human ACLs from male or female donors, we engineered ligaments and determined that ligaments made from female ACL cells had more collagen and were equal in strength to those made from male ACL cells. We then treated engineered ligaments for 14 days with low (5 pg/ml), medium (50 pg/ml), or high (500 pg/ml) estrogen, corresponding to the range of in vivo serum estrogen concentrations and found that collagen within the grafts increased without a commensurate increase in mechanical strength. Mimicking the menstrual cycle, with 12 days of low estrogen followed by 2 days of physiologically high estrogen, resulted in a decrease in engineered ligament mechanical function with no change in the amount of collagen in the graft. The decrease in mechanical stiffness corresponded with a 61.7 and 76.9% decrease in the activity of collagen cross-linker lysyl oxidase with 24 and 48 h of high estrogen, respectively. Similarly, grafts treated with the lysyl oxidase inhibitor β-aminoproprionitrile (BAPN) for 24 h showed a significant decrease in ligament mechanical strength [control (CON) = 1.58 ± 0.06 N; BAPN = 1.06 ± 0.13 N] and stiffness (CON = 7.7 ± 0.46 MPa; BAPN = 6.1 ± 0.71 MPa) without changing overall collagen levels (CON = 396 ± 11.5 μg; BAPN = 382 ± 11.6 μg). Together, these data suggest that the rise in estrogen during the follicular phase decreases lysyl oxidase activity in our engineered ligament model and if this occurs in vivo may decrease the stiffness of ligaments and contribute to the elevated rate of ACL rupture in women. Copyright © 2015 the American Physiological Society.

Ticagrelor Improves Endothelial Function by Decreasing Circulating Epidermal Growth Factor (EGF

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Francesco Vieceli Dalla Sega

2018-04-01

Full Text Available Ticagrelor is one of the most powerful P2Y12 inhibitor. We have recently reported that, in patients with concomitant Stable Coronary Artery Disease (SCAD and Chronic Obstructive Pulmonary Disease (COPD undergoing percutaneous coronary intervention (PCI, treatment with ticagrelor, as compared to clopidogrel, is associated with an improvement of the endothelial function (Clinical Trial NCT02519608. In the present study, we showed that, in the same population, after 1 month treatment with ticagrelor, but not with clopidogrel, there is a decrease of the circulating levels of epidermal growth factor (EGF and that these changes in circulating levels of EGF correlate with on-treatment platelet reactivity. Furthermore, in human umbilical vein endothelial cells (HUVEC incubated with sera of the patients treated with ticagrelor, but not with clopidogrel there is an increase of p-eNOS levels. Finally, analyzing the changes in EGF and p-eNOS levels after treatment, we observed an inverse correlation between p-eNOS and EGF changes only in the ticagrelor group. Causality between EGF and eNOS activation was assessed in vitro in HUVEC where we showed that EGF decreases eNOS activity in a dose dependent manner. Taken together our data indicate that ticagrelor improves endothelial function by lowering circulating EGF that results in the activation of eNOS in the vascular endothelium.

Convergence rates and finite-dimensional approximations for nonlinear ill-posed problems involving monotone operators in Banach spaces

International Nuclear Information System (INIS)

Nguyen Buong.

1992-11-01

The purpose of this paper is to investigate convergence rates for an operator version of Tikhonov regularization constructed by dual mapping for nonlinear ill-posed problems involving monotone operators in real reflective Banach spaces. The obtained results are considered in combination with finite-dimensional approximations for the space. An example is considered for illustration. (author). 15 refs

Simplest bifurcation diagrams for monotone families of vector fields on a torus

Science.gov (United States)

Baesens, C.; MacKay, R. S.

2018-06-01

In part 1, we prove that the bifurcation diagram for a monotone two-parameter family of vector fields on a torus has to be at least as complicated as the conjectured simplest one proposed in Baesens et al (1991 Physica D 49 387–475). To achieve this, we define ‘simplest’ by sequentially minimising the numbers of equilibria, Bogdanov–Takens points, closed curves of centre and of neutral saddle, intersections of curves of centre and neutral saddle, Reeb components, other invariant annuli, arcs of rotational homoclinic bifurcation of horizontal homotopy type, necklace points, contractible periodic orbits, points of neutral horizontal homoclinic bifurcation and half-plane fan points. We obtain two types of simplest case, including that initially proposed. In part 2, we analyse the bifurcation diagram for an explicit monotone family of vector fields on a torus and prove that it has at most two equilibria, precisely four Bogdanov–Takens points, no closed curves of centre nor closed curves of neutral saddle, at most two Reeb components, precisely four arcs of rotational homoclinic connection of ‘horizontal’ homotopy type, eight horizontal saddle-node loop points, two necklace points, four points of neutral horizontal homoclinic connection, and two half-plane fan points, and there is no simultaneous existence of centre and neutral saddle, nor contractible homoclinic connection to a neutral saddle. Furthermore, we prove that all saddle-nodes, Bogdanov–Takens points, non-neutral and neutral horizontal homoclinic bifurcations are non-degenerate and the Hopf condition is satisfied for all centres. We also find it has four points of degenerate Hopf bifurcation. It thus provides an example of a family satisfying all the assumptions of part 1 except the one of at most one contractible periodic orbit.

Minimum-error quantum distinguishability bounds from matrix monotone functions: A comment on 'Two-sided estimates of minimum-error distinguishability of mixed quantum states via generalized Holevo-Curlander bounds' [J. Math. Phys. 50, 032106 (2009)

International Nuclear Information System (INIS)

Tyson, Jon

2009-01-01

Matrix monotonicity is used to obtain upper bounds on minimum-error distinguishability of arbitrary ensembles of mixed quantum states. This generalizes one direction of a two-sided bound recently obtained by the author [J. Tyson, J. Math. Phys. 50, 032106 (2009)]. It is shown that the previously obtained special case has unique properties.

Comportement des poteaux mixtes acier-béton soumis aux sollicitations de type monotone. Étude expérimentale

Directory of Open Access Journals (Sweden)

Cristina Câmpian

2006-01-01

Full Text Available For more than one hundred years the construction system based on steel or composite steel -- concrete frames became one of the more utilized types of building in civil engineering domain. For an optimal dimensioning of the structure, the engineers had to found a compromise between the structural exigency for the resistance, stiffness and ductility, on one side, and architectural exigency on the other side. Three monotonic tests and nine cyclic tests according to ECCS loading procedure were carried out in Cluj Laboratory of Concrete. The tested composite columns of fully encased type were subject to a variable transverse load at one end while keeping a constant value of the axial compression force into them. An analytical interpretation is given for the calculus of column stiffness for the monotonic tests, making a comparation with the latest versions of the Eurocode 4 stiffness formula.

Methyl-parathion decreases sperm function and fertilization capacity after targeting spermatocytes and maturing spermatozoa

Energy Technology Data Exchange (ETDEWEB)

Pina-Guzman, Belem; Sanchez-Gutierrez, M.; Marchetti, Francesco; Hernandez-Ochoa, I.; Solis-Heredia, M.J .; Quintanilla-Vega, B.

2009-05-03

Paternal germline exposure to organophosphorous pesticides (OP) has been associated with reproductive failures and adverse effects in the offspring. Methyl parathion (Me-Pa), a worldwide-used OP, has reproductive adverse effects and is genotoxic to sperm. Oxidative damage has been involved in the genotoxic and reproductive effects of OP. The purpose of this study was to determine the effects of Me-Pa on spermatozoa function and ability to fertilize. Male mice were exposed to Me-Pa (20 mg/kg bw, i.p.) and spermatozoa from epididymis-vas deferens were collected at 7 or 28 days post-treatment (dpt) to assess the effects on maturing spermatozoa and spermatocytes, respectively. DNA damage was evaluated by nick translation (NT-positive cells) and SCSA (percentDFI); lipoperoxidation (LPO) by malondialdehyde production; sperm function by spontaneous- and induced-acrosome reactions (AR); mitochondrial membrane potential (MMP) by using the JC-1 flurochrome; and, fertilization ability by an in vitro assay and in vivo mating. Results showed alterations in DNA integrity (percentDFI and NT-positive cells) at 7 and 28 dpt, in addition to decreased sperm quality and a decrease in induced-AR; reduced MMP and LPO was observed only at 7 dpt. We found negative correlations between LPO and all sperm alterations. Altered sperm functional parameters were associated with reduced fertilization rates at both times, evaluated either in vitro or in vivo. These results show that Me-Pa exposure of maturing spermatozoa and spermatocytes affects many sperm functional parameters that result in a decreased fertilizing capacity. Oxidative stress seems to be a likely mechanism ofthe detrimental effects of Me-Pa in male germ cells.

Low dose effects and non-monotonic dose responses for endocrine active chemicals: Science to practice workshop: Workshop summary

DEFF Research Database (Denmark)

Beausoleil, Claire; Ormsby, Jean-Nicolas; Gies, Andreas

2013-01-01

A workshop was held in Berlin September 12–14th 2012 to assess the state of the science of the data supporting low dose effects and non-monotonic dose responses (“low dose hypothesis”) for chemicals with endocrine activity (endocrine disrupting chemicals or EDCs). This workshop consisted of lectu...

The Marotto Theorem on planar monotone or competitive maps

International Nuclear Information System (INIS)

Yu Huang

2004-01-01

In 1978, Marotto generalized Li-Yorke's results on the criterion for chaos from one-dimensional discrete dynamical systems to n-dimensional discrete dynamical systems, showing that the existence of a non-degenerate snap-back repeller implies chaos in the sense of Li-Yorke. This theorem is very useful in predicting and analyzing discrete chaos in multi-dimensional dynamical systems. Yet, besides it is well known that there exists an error in the conditions of the original Marotto Theorem, and several authors had tried to correct it in different way, Chen, Hsu and Zhou pointed out that the verification of 'non-degeneracy' of a snap-back repeller is the most difficult in general and expected, 'almost beyond reasonable doubt', that the existence of only degenerate snap-back repeller still implies chaotic, which was posed as a conjecture by them. In this paper, we shall give necessary and sufficient conditions of chaos in the sense of Li-Yorke for planar monotone or competitive discrete dynamical systems and solve Chen-Hsu-Zhou Conjecture for such kinds of systems

Evaluation of the Monotonic Lagrangian Grid and Lat-Long Grid for Air Traffic Management

Science.gov (United States)

Kaplan, Carolyn; Dahm, Johann; Oran, Elaine; Alexandrov, Natalia; Boris, Jay

2011-01-01

The Air Traffic Monotonic Lagrangian Grid (ATMLG) is used to simulate a 24 hour period of air traffic flow in the National Airspace System (NAS). During this time period, there are 41,594 flights over the United States, and the flight plan information (departure and arrival airports and times, and waypoints along the way) are obtained from an Federal Aviation Administration (FAA) Enhanced Traffic Management System (ETMS) dataset. Two simulation procedures are tested and compared: one based on the Monotonic Lagrangian Grid (MLG), and the other based on the stationary Latitude-Longitude (Lat- Long) grid. Simulating one full day of air traffic over the United States required the following amounts of CPU time on a single processor of an SGI Altix: 88 s for the MLG method, and 163 s for the Lat-Long grid method. We present a discussion of the amount of CPU time required for each of the simulation processes (updating aircraft trajectories, sorting, conflict detection and resolution, etc.), and show that the main advantage of the MLG method is that it is a general sorting algorithm that can sort on multiple properties. We discuss how many MLG neighbors must be considered in the separation assurance procedure in order to ensure a five-mile separation buffer between aircraft, and we investigate the effect of removing waypoints from aircraft trajectories. When aircraft choose their own trajectory, there are more flights with shorter duration times and fewer CD&R maneuvers, resulting in significant fuel savings.

Decreased resting functional connectivity after traumatic brain injury in the rat.

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Asht Mangal Mishra

Full Text Available Traumatic brain injury (TBI contributes to about 10% of acquired epilepsy. Even though the mechanisms of post-traumatic epileptogenesis are poorly known, a disruption of neuronal networks predisposing to altered neuronal synchrony remains a viable candidate mechanism. We tested a hypothesis that resting state BOLD-fMRI functional connectivity can reveal network abnormalities in brain regions that are connected to the lesioned cortex, and that these changes associate with functional impairment, particularly epileptogenesis. TBI was induced using lateral fluid-percussion injury in seven adult male Sprague-Dawley rats followed by functional imaging at 9.4T 4 months later. As controls we used six sham-operated animals that underwent all surgical operations but were not injured. Electroencephalogram (EEG-functional magnetic resonance imaging (fMRI was performed to measure resting functional connectivity. A week after functional imaging, rats were implanted with bipolar skull electrodes. After recovery, rats underwent pentyleneterazol (PTZ seizure-susceptibility test under EEG. For image analysis, four pairs of regions of interests were analyzed in each hemisphere: ipsilateral and contralateral frontal and parietal cortex, hippocampus, and thalamus. High-pass and low-pass filters were applied to functional imaging data. Group statistics comparing injured and sham-operated rats and correlations over time between each region were calculated. In the end, rats were perfused for histology. None of the rats had epileptiform discharges during functional imaging. PTZ-test, however revealed increased seizure susceptibility in injured rats as compared to controls. Group statistics revealed decreased connectivity between the ipsilateral and contralateral parietal cortex and between the parietal cortex and hippocampus on the side of injury as compared to sham-operated animals. Injured animals also had abnormal negative connectivity between the ipsilateral and

Decreased functional connectivity in schizophrenia: The relationship between social functioning, social cognition and graph theoretical network measures.

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Erdeniz, Burak; Serin, Emin; İbadi, Yelda; Taş, Cumhur

2017-12-30

Schizophrenia is a complex disorder in which abnormalities in brain connectivity and social functioning play a central role. The aim of this study is to explore small-world network properties, and understand their relationship with social functioning and social cognition in the context of schizophrenia, by testing functional connectivity differences in network properties and its relation to clinical behavioral measures. Resting-state fMRI time series data were acquired from 23 patients diagnosed with schizophrenia and 23 healthy volunteers. The results revealed that patients with schizophrenia show significantly decreased connectivity between a range of brain regions, particularly involving connections among the right orbitofrontal cortex, bilateral putamen and left amygdala. Furthermore, topological properties of functional brain networks in patients with schizophrenia were characterized by reduced path length compared to healthy controls; however, no significant difference was found for clustering coefficient, local efficiency or global efficiency. Additionally, we found that nodal efficiency of the amygdala and the putamen were significantly correlated with the independence-performance subscale of social functioning scale (SFC), and Reading the Mind in the Eyes test; however, the correlations do not survive correction for multiple comparison. The current results help to clarify the relationship between social functioning deficits and topological brain measures in schizophrenia. Copyright © 2017 Elsevier B.V. All rights reserved.

Mast cell stabilization decreases cardiomyocyte and LV function in dogs with isolated mitral regurgitation.

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Pat, Betty; Killingsworth, Cheryl; Chen, Yuanwen; Gladden, James D; Walcott, Greg; Powell, Pamela C; Denney, Thomas; Gupta, Himanshu; Desai, Ravi; Tillson, Michael; Dillon, A Ray; Dell'italia, Louis J

2010-09-01

Mast cells are increased in isolated mitral regurgitation (MR) in the dog and may mediate extracellular matrix loss and left ventricular (LV) dilatation. We tested the hypothesis that mast cell stabilization would attenuate LV remodeling and improve function in the MR dog. MR was induced in adult dogs randomized to no treatment (MR, n = 5) or to the mast cell stabilizer, ketotifen (MR + MCS, n = 4) for 4 months. LV hemodynamics were obtained at baseline and after 4 months of MR and magnetic resonance imaging (MRI) was performed at sacrifice. MRI-derived, serial, short-axis LV end-diastolic (ED) and end-systolic (ES) volumes, LVED volume/mass ratio, and LV 3-dimensional radius/wall thickness were increased in MR and MR + MCS dogs compared with normal dogs (n = 6) (P < .05). Interstitial collagen was decreased by 30% in both MR and MR + MCS versus normal dogs (P < .05). LV contractility by LV maximum time-varying elastance was significantly depressed in MR and MR + MCS dogs. Furthermore, cardiomyocyte fractional shortening was decreased in MR versus normal dogs and further depressed in MR + MCS dogs (P < .05). In vitro administration of ketotifen to normal cardiomyocytes also significantly decreased fractional shortening and calcium transients. Chronic mast cell stabilization did not attenuate eccentric LV remodeling or collagen loss in MR. However, MCS therapy had a detrimental effect on LV function because of a direct negative inotropic effect on cardiomyocyte function. Published by Elsevier Inc.

Application of a repetitive process setting to design of monotonically convergent iterative learning control

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Boski, Marcin; Paszke, Wojciech

2015-11-01

This paper deals with the problem of designing an iterative learning control algorithm for discrete linear systems using repetitive process stability theory. The resulting design produces a stabilizing output feedback controller in the time domain and a feedforward controller that guarantees monotonic convergence in the trial-to-trial domain. The results are also extended to limited frequency range design specification. New design procedure is introduced in terms of linear matrix inequality (LMI) representations, which guarantee the prescribed performances of ILC scheme. A simulation example is given to illustrate the theoretical developments.

Monotonous and oscillation instability of mechanical equilibrium of isothermal three-components mixture with zero-gradient density

International Nuclear Information System (INIS)

Zhavrin, Yu.I.; Kosov, V.N.; Kul'zhanov, D.U.; Karataev, K.K.

2000-01-01

Presence of two types of instabilities of mechanical equilibrium of a mixture experimentally is shown at an isothermal diffusion of multicomponent system with zero gradient of density/ Theoretically is proved, that partial Rayleigh numbers R 1 , R 2 having different signs, there are two areas with monotonous (R 1 2 < by 0) instability. The experimental data confirm presence of these areas and satisfactory are described by the represented theory. (author)

Further properties of the zeros of Bessel functions

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Carla Giordano

1987-11-01

Full Text Available New monotonicity and convexity properties for the zeros cνk  (k=1,2,... of the Bessel functions are proved. New inequalities for cνk are also given. These inequalities are useful for small values of ν.

Normal Parathyroid Function with Decreased Bone Mineral Density in Treated Celiac Disease

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Bernard Lemieux

2001-01-01

Full Text Available Decreased bone mineral density (BMD has been reported in patients with celiac disease in association with secondary hyperparathyroidism. The present study investigated whether basal parathyroid hormone (PTH remained elevated and whether abnormalities of parathyroid function were still present in celiac disease patients treated with a gluten-free diet. Basal seric measurements of calcium and phosphate homeostasis and BMD were obtained in 17 biopsy-proven patients under treatment for a mean period of 5.7±3.7 years (range 1.1 to 15.9. In addition, parathyroid function was studied with calcium chloride and sodium citrate infusions in seven patients. Basal measurements of patients were compared with those of 26 normal individuals, while parathyroid function results were compared with those of seven sex- and age-matched controls. Basal results were similar in patients and controls except for intact PTH (I-PTH (3.77±0.88 pmol/L versus 2.28±0.63 pmol/L, P<0.001, which was higher in the former group but still within normal limits. Mean 25-hydroxy vitamin D and 1,25-dihydroxy vitamin D values were normal in patients. Parathyroid function results were also found to be similar in both groups. Compared with a reference population of the same age (Z score, patients had significantly lower BMDs of the hip (-0.60±0.96 SDs, P<0.05 and lumbar spine (-0.76±1.15 SDs, P<0.05. T scores were also decreased for the hip (-1.3±0.9 SDs, P<0.0001 and lumbar spine (-1.4±1.35 SDs, P<0.0001, with two to three patients being osteoporotic (T score less than -2.5 SDs and seven to eight osteopenic (T score less than -1 SDs but greater than or equal to -2.5 SDs in at least one site. Height and weight were the only important determinants of BMD values by multivariate or logistical regression analysis in these patients. The results show higher basal I-PTH values with normal parathyroid function in treated celiac disease. Height and weight values are, but I-PTH values are not

The influence of gas–solid reaction kinetics in models of thermochemical heat storage under monotonic and cyclic loading

International Nuclear Information System (INIS)

Nagel, T.; Shao, H.; Roßkopf, C.; Linder, M.; Wörner, A.; Kolditz, O.

2014-01-01

Highlights: • Detailed analysis of cyclic and monotonic loading of thermochemical heat stores. • Fully coupled reactive heat and mass transport. • Reaction kinetics can be simplified in systems limited by heat transport. • Operating lines valid during monotonic and cyclic loading. • Local integral degree of conversion to capture heterogeneous material usage. - Abstract: Thermochemical reactions can be employed in heat storage devices. The choice of suitable reactive material pairs involves a thorough kinetic characterisation by, e.g., extensive thermogravimetric measurements. Before testing a material on a reactor level, simulations with models based on the Theory of Porous Media can be used to establish its suitability. The extent to which the accuracy of the kinetic model influences the results of such simulations is unknown yet fundamental to the validity of simulations based on chemical models of differing complexity. In this article we therefore compared simulation results on the reactor level based on an advanced kinetic characterisation of a calcium oxide/hydroxide system to those obtained by a simplified kinetic model. Since energy storage is often used for short term load buffering, the internal reactor behaviour is analysed under cyclic partial loading and unloading in addition to full monotonic charge/discharge operation. It was found that the predictions by both models were very similar qualitatively and quantitatively in terms of thermal power characteristics, conversion profiles, temperature output, reaction duration and pumping powers. Major differences were, however, observed for the reaction rate profiles themselves. We conclude that for systems not limited by kinetics the simplified model seems sufficient to estimate the reactor behaviour. The degree of material usage within the reactor was further shown to strongly vary under cyclic loading conditions and should be considered when designing systems for certain operating regimes

Functional connectivity decreases in autism in emotion, self, and face circuits identified by Knowledge-based Enrichment Analysis.

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Cheng, Wei; Rolls, Edmund T; Zhang, Jie; Sheng, Wenbo; Ma, Liang; Wan, Lin; Luo, Qiang; Feng, Jianfeng

2017-03-01

A powerful new method is described called Knowledge based functional connectivity Enrichment Analysis (KEA) for interpreting resting state functional connectivity, using circuits that are functionally identified using search terms with the Neurosynth database. The method derives its power by focusing on neural circuits, sets of brain regions that share a common biological function, instead of trying to interpret single functional connectivity links. This provides a novel way of investigating how task- or function-related networks have resting state functional connectivity differences in different psychiatric states, provides a new way to bridge the gap between task and resting-state functional networks, and potentially helps to identify brain networks that might be treated. The method was applied to interpreting functional connectivity differences in autism. Functional connectivity decreases at the network circuit level in 394 patients with autism compared with 473 controls were found in networks involving the orbitofrontal cortex, anterior cingulate cortex, middle temporal gyrus cortex, and the precuneus, in networks that are implicated in the sense of self, face processing, and theory of mind. The decreases were correlated with symptom severity. Copyright © 2017. Published by Elsevier Inc.

Kyphoplasty increases vertebral height, decreases both pain score and opiate requirements while improving functional status.

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Tolba, Reda; Bolash, Robert B; Shroll, Joshua; Costandi, Shrif; Dalton, Jarrod E; Sanghvi, Chirag; Mekhail, Nagy

2014-03-01

Vertebral compression fractures can result from advanced osteoporosis, or less commonly from metastatic or traumatic insults to the vertebral column, and result in disabling pain and decreased functional capacity. Various vertebral augmentation options including kyphoplasty aim at preventing the sequelae of pain and immobility that can develop as the result of the vertebral fractures. The mechanism for pain relief following kyphoplasty is not entirely understood, and the restoration of a portion of the lost vertebral height is a subject of debate. We retrospectively reviewed radiographic imaging, pain relief, analgesic intake and functional outcomes in 67 consecutive patients who underwent single- or multilevel kyphoplasty with the primary goal of quantifying the restoration of lost vertebral height. We observed a mean of 45% of the lost vertebral height restored postprocedurally. Secondarily, kyphoplasty was associated with significant decreases in pain scores, daily morphine consumption and improvement in patient-reported functional measures. © 2013 World Institute of Pain.

Subacute stress and chronic stress interact to decrease intestinal barrier function in rats.

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Lauffer, Adriana; Vanuytsel, Tim; Vanormelingen, Christophe; Vanheel, Hanne; Salim Rasoel, Shadea; Tóth, Joran; Tack, Jan; Fornari, Fernando; Farré, Ricard

2016-01-01

Psychological stress increases intestinal permeability, potentially leading to low-grade inflammation and symptoms in functional gastrointestinal disorders. We assessed the effect of subacute, chronic and combined stress on intestinal barrier function and mast cell density. Male Wistar rats were allocated to four experimental groups (n = 8/group): 1/sham; 2/subacute stress (isolation and limited movement for 24 h); 3/chronic crowding stress for 14 days and 4/combined subacute and chronic stress. Jejunum and colon were collected to measure: transepithelial electrical resistance (TEER; a measure of epithelial barrier function); gene expression of tight junction molecules; mast cell density. Plasma corticosterone concentration was increased in all three stress conditions versus sham, with highest concentrations in the combined stress condition. TEER in the jejunum was decreased in all stress conditions, but was significantly lower in the combined stress condition than in the other groups. TEER in the jejunum correlated negatively with corticosterone concentration. Increased expression of claudin 1, 5 and 8, occludin and zonula occludens 1 mRNAs was detected after subacute stress in the jejunum. In contrast, colonic TEER was decreased only after combined stress, and the expression of tight junction molecules was unaltered. Increased mast cell density was observed in the chronic and combined stress condition in the colon only. In conclusion, our data show that chronic stress sensitizes the gastrointestinal tract to the effects of subacute stress on intestinal barrier function; different underlying cellular and molecular alterations are indicated in the small intestine versus the colon.

Global convergence of periodic solution of neural networks with discontinuous activation functions

International Nuclear Information System (INIS)

Huang Lihong; Guo Zhenyuan

2009-01-01

In this paper, without assuming boundedness and monotonicity of the activation functions, we establish some sufficient conditions ensuring the existence and global asymptotic stability of periodic solution of neural networks with discontinuous activation functions by using the Yoshizawa-like theorem and constructing proper Lyapunov function. The obtained results improve and extend previous works.

Decreases in renal functional reserve and proximal tubular fluid output in conscious oophorectomized rats

DEFF Research Database (Denmark)

Nielsen, Camilla Birch; Flyvbjerg, Allan; Bruun, Jens Meldgaard

2003-01-01

Age-dependent glomerulosclerosis with reduced GFR develops earlier among men than among women. Therefore, whether female sex hormones could prevent the age-dependent decrease in GFR was investigated. The kidney function in oophorectomized rats treated with placebo (OOX group), estrogen (OOX+E(2...... effects were prevented with administration of estrogen. Sham-operated rats demonstrated values for renal functional reserve and fractional lithium excretion that were between those observed for the OOX group and the groups treated with sex hormones....

Decreased functional connectivity between ventral tegmental area and nucleus accumbens in Internet gaming disorder: evidence from resting state functional magnetic resonance imaging.

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Zhang, Jin-Tao; Ma, Shan-Shan; Yip, Sarah W; Wang, Ling-Jiao; Chen, Chao; Yan, Chao-Gan; Liu, Lu; Liu, Ben; Deng, Lin-Yuan; Liu, Qin-Xue; Fang, Xiao-Yi

2015-11-18

Internet gaming disorder (IGD) has become an increasing mental health problem worldwide. Decreased resting-state functional connectivity (rsFC) between the ventral tegmental area (VTA) and the nucleus accumbens (NAcc) has been found in substance use and is thought to play an important role in the development of substance addiction. However, rsFC between the VTA and NAcc in a non-substance addiction, such as IGD, has not been assessed previously. The current study aimed to investigate: (1) if individuals with IGD exhibit alterations in VTA-NAcc functional connectivity; and (2) whether VTA-NAcc functional connectivity is associated with subjective Internet craving. Thirty-five male participants with IGD and 24 healthy control (HC) individuals participated in resting-state functional magnetic resonance imaging. Regions of interest (left NAcc, right NAcc and VTA) were selected based on the literature and were defined by placing spheres centered on Talairach Daemon coordinates. In comparison with HCs, individuals with IGD had significantly decreased rsFC between the VTA and right NAcc. Resting-state functional connectivity strength between the VTA and right NAcc was negatively correlated with self-reported subjective craving for the Internet. These results suggest possible neural functional similarities between individuals with IGD and individuals with substance addictions.

Sonographic decreased echogenicity of thyroid parenchyma in asymptomatic population: Correction with thyroid function and thyroid autoimmune activity

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Park, Ji Yeon; Park, Noh Hyuck; Park, Chan Sub; Lee, Ji Ye [Dept. of Radiology, Myongji Hospital, Seonam University College of Medicine, Goyang (Korea, Republic of); Chun, Kyung Ah [Dept. of Radiology, Catholic Kwandong University School of Medicine, Gangneung (Korea, Republic of); Yi, Seong Yoon [Div. of Hematology-Oncology, Dept. of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang (Korea, Republic of); Park, Hee Jin [Dept. of of Radiology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul (Korea, Republic of)

2016-09-15

The aim of the study was to evaluate the correlation between decreased echogenicity of thyroid and thyroid hormones or autoantibodies. From January 2009 to December 2011, 543 patients with decreased parenchymal echogenicity [M:F = 133:410, median age: 42 years (range: 9-82 years)], who did not have solid nodule, symptom or medication related to thyroid and underwent thyroid function test were retrospectively reviewed. Images were classified based on the degree of hypoechogenicity, heterogenicity or thyroid size. 1) Group A: mild decreased echogenicity, group B: marked decreased echogenicity, 2) group Ho: homogeneous echogenicity, group He: heterogeneous echogenicity, 3) group 1: decreased size, group 2: normal size, group 3: increased size. Differences in triiodiothyronyne (T3), free-thyroxine (fT4), thyrotropin (TSH), anti-thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb), and anti-TSH receptor antibody (TSH-rAb) were evaluated among groups. T3, fT4, and TSH levels differed between groups A and B (p < 0.001, p = 0.001, p < 0.001). TgAb and TPOAb of group B were higher than group A (p = 0.006, p < 0.001). TPOAb of group He was higher than group Ho (p < 0.001). TSH-rAb and TPOAb of group 3 were higher than group 2 (p = 0.017, p < 0.001). The patients with findings of markedly decreased, heterogeneous echogenicity or thyroid enlargement may have abnormal thyroid function and autoantibodies. These may facilitate the physicians' decision to order tests for thyroid function and autoimmune activity.

Sharp inequalities for tangent function with applications

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Hui-Lin Lv

2017-05-01

Full Text Available Abstract In the article, we present new bounds for the function e t cot ( t − 1 $e^{t\\cot(t-1}$ on the interval ( 0 , π / 2 $(0, \\pi/2$ and find sharp estimations for the Sine integral and the Catalan constant based on a new monotonicity criterion for the quotient of power series, which refine the Redheffer and Becker-Stark type inequalities for tangent function.

Effect of tributyltin (TBT) on ATP levels in human natural killer (NK) cells: relationship to TBT-induced decreases in NK function.

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Dudimah, Fred D; Odman-Ghazi, Sabah O; Hatcher, Frank; Whalen, Margaret M

2007-01-01

The purpose of this study was to investigate the role that tributyltin (TBT)-induced decreases in ATP levels may play in TBT-induced decreases in the tumor lysing (lytic) function of natural killer (NK) cells. NK cells are a subset of lymphocytes that act as an initial immune defense against tumor cells and virally infected cells. TBT is an environmental contaminant that has been detected in human blood, which has been shown to interfere with ATP synthesis. Previous studies have shown that TBT is able to decrease very significantly the lytic function of NK cells. In this study NK cells were exposed to various concentrations of TBT and to two other compounds that interfere with ATP synthesis (rotenone a complex I inhibitor and oligomycin an ATP synthase inhibitor) for various lengths of time before determining the levels of ATP and lytic function. Exposures of NK cells to 10, 25, 50 and 100 nm TBT did not significantly reduce ATP levels after 24 h. However, these same exposures caused significant decreases in cytotoxic function. Studies of brief 1 h exposures to a range of TBT, rotenone and oligomycin concentrations followed by 24 h, 48 h and 6 day periods in compound-free media prior to assaying for ATP levels or cytotoxic function showed that each of the compounds caused persistent decreases in ATP levels and lytic function of NK cells. Exposures to 0.05-5 microm rotenone or oligomycin for 1 h reduced ATP levels by 20-25% but did not have any measurable effect on the ability of NK cells to lyse tumor cells. ATP levels were also decreased by about 20-25% after 24 h or 48 h exposures to rotenone or oligomycin (0.5 microm ), and the lytic function was decreased by about 50%. The results suggest that TBT-induced decreases in ATP levels were not responsible for the loss of cytotoxic function seen at 1 h and 24 h. However, TBT-induced decreases of NK-ATP levels may be at least in part responsible for losses of NK-cytotoxic function seen after 48 h and 6 day exposures

Condition-based inspection/replacement policies for non-monotone deteriorating systems with environmental covariates

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Zhao Xuejing [Universite de Technologie de Troyes, Institut Charles Delaunay and STMR UMR CNRS 6279, 12 rue Marie Curie, 10010 Troyes (France); School of mathematics and statistics, Lanzhou University, Lanzhou 730000 (China); Fouladirad, Mitra, E-mail: mitra.fouladirad@utt.f [Universite de Technologie de Troyes, Institut Charles Delaunay and STMR UMR CNRS 6279, 12 rue Marie Curie, 10010 Troyes (France); Berenguer, Christophe [Universite de Technologie de Troyes, Institut Charles Delaunay and STMR UMR CNRS 6279, 12 rue Marie Curie, 10010 Troyes (France); Bordes, Laurent [Universite de Pau et des Pays de l' Adour, LMA UMR CNRS 5142, 64013 PAU Cedex (France)

2010-08-15

The aim of this paper is to discuss the problem of modelling and optimising condition-based maintenance policies for a deteriorating system in presence of covariates. The deterioration is modelled by a non-monotone stochastic process. The covariates process is assumed to be a time-homogenous Markov chain with finite state space. A model similar to the proportional hazards model is used to show the influence of covariates on the deterioration. In the framework of the system under consideration, an appropriate inspection/replacement policy which minimises the expected average maintenance cost is derived. The average cost under different conditions of covariates and different maintenance policies is analysed through simulation experiments to compare the policies performances.

Condition-based inspection/replacement policies for non-monotone deteriorating systems with environmental covariates

International Nuclear Information System (INIS)

Zhao Xuejing; Fouladirad, Mitra; Berenguer, Christophe; Bordes, Laurent

2010-01-01

The aim of this paper is to discuss the problem of modelling and optimising condition-based maintenance policies for a deteriorating system in presence of covariates. The deterioration is modelled by a non-monotone stochastic process. The covariates process is assumed to be a time-homogenous Markov chain with finite state space. A model similar to the proportional hazards model is used to show the influence of covariates on the deterioration. In the framework of the system under consideration, an appropriate inspection/replacement policy which minimises the expected average maintenance cost is derived. The average cost under different conditions of covariates and different maintenance policies is analysed through simulation experiments to compare the policies performances.

An Optimal Augmented Monotonic Tracking Controller for Aircraft Engines with Output Constraints

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Jiakun Qin

2017-01-01

Full Text Available This paper proposes a novel min-max control scheme for aircraft engines, with the aim of transferring a set of regulated outputs between two set-points, while ensuring a set of auxiliary outputs remain within prescribed constraints. In view of this, an optimal augmented monotonic tracking controller (OAMTC is proposed, by considering a linear plant with input integration, to enhance the ability of the control system to reject uncertainty in system parameters and ensure no crossing limits. The key idea is to use the eigenvalue and eigenvector placement method and genetic algorithms to shape the output responses. The approach is validated by numerical simulation. The results show that the designed OAMTC controller can achieve a satisfactory dynamic and steady performance and keep the auxiliary outputs within constraints in the transient regime.

A new efficient algorithm for computing the imprecise reliability of monotone systems

International Nuclear Information System (INIS)

Utkin, Lev V.

2004-01-01

Reliability analysis of complex systems by partial information about reliability of components and by different conditions of independence of components may be carried out by means of the imprecise probability theory which provides a unified framework (natural extension, lower and upper previsions) for computing the system reliability. However, the application of imprecise probabilities to reliability analysis meets with a complexity of optimization problems which have to be solved for obtaining the system reliability measures. Therefore, an efficient simplified algorithm to solve and decompose the optimization problems is proposed in the paper. This algorithm allows us to practically implement reliability analysis of monotone systems under partial and heterogeneous information about reliability of components and under conditions of the component independence or the lack of information about independence. A numerical example illustrates the algorithm

Temporal integration of loudness as a function of level

DEFF Research Database (Denmark)

Florentine, Mary; Buus, Søren; Poulsen, Torben

1996-01-01

Absolute thresholds were measured for 5-, 30-, and 200-ms stimuli using an adaptive, forced choice procedure. Temporal integration of loudness for these durations was also measured for a 1-kHz tone and for broadband noises over a range of 5-80 dB SL (noise) and 5-90 dB SL (tones). Results show...... that temporal integration (defined as the level difference between equally loud 5- and 200-ms stimuli) varies non-monotonically with level. The temporal integration is about 10-12 dB near threshold, increases to 18-19 dB when the 5-ms signal is about 56 dB SPL (tone) and 76 dB SPL (noise), decreases again...... that the growth of loudness may, at least in part, be consistent with the nonlinear input/output function of the basilar membrane....

Exponential stability in a scalar functional differential equation

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Pituk Mihály

2006-01-01

Full Text Available We establish a criterion for the global exponential stability of the zero solution of the scalar retarded functional differential equation whose linear part generates a monotone semiflow on the phase space with respect to the exponential ordering, and the nonlinearity has at most linear growth.

Monotone Hybrid Projection Algorithms for an Infinitely Countable Family of Lipschitz Generalized Asymptotically Quasi-Nonexpansive Mappings

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Watcharaporn Cholamjiak

2009-01-01

Full Text Available We prove a weak convergence theorem of the modified Mann iteration process for a uniformly Lipschitzian and generalized asymptotically quasi-nonexpansive mapping in a uniformly convex Banach space. We also introduce two kinds of new monotone hybrid methods and obtain strong convergence theorems for an infinitely countable family of uniformly Lipschitzian and generalized asymptotically quasi-nonexpansive mappings in a Hilbert space. The results improve and extend the corresponding ones announced by Kim and Xu (2006 and Nakajo and Takahashi (2003.

Use of the nonsteady monotonic heating method for complex determination of thermophysical properties of chemically reacting mixture in the case of non-equilibrium proceeding of the chemical reaction

International Nuclear Information System (INIS)

Serebryanyj, G.Z.

1984-01-01

Theoretical analysis is made for the monotonic heating method as applied for complex determination of thermophysical properties of chemically reacting gases. The possibility is shown of simultaneous determination of frozen and equilibrium heat capacity, frozen and equilibrium heat conduction provided non-equilibrium occuring of the reaction in the wide range of temperatures and pressures. The monotonic heating method can be used for complex determination of thermophysical properties of chemically reacting systems in case of non-equilibrium proceeding of the chemical reaction

The Soluble Epoxide Hydrolase Inhibitor AR9281 Decreases Blood Pressure, Ameliorates Renal Injury and Improves Vascular Function in Hypertension

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Sean Shaw

2009-12-01

Full Text Available Soluble epoxide hydrolase inhibitors (sEHIs are demonstrating promise as potential pharmaceutical agents for the treatment of cardiovascular disease, diabetes, inflammation, and kidney disease. The present study determined the ability of a first-inclass sEHI, AR9281, to decrease blood pressure, improve vascular function, and decrease renal inflammation and injury in angiotensin hypertension. Rats were infused with angiotensin and AR9281 was given orally during the 14-day infusion period. Systolic blood pressure averaged 180 ± 5 mmHg in vehicle treated and AR9281 treatment significantly lowered blood pressure to 142 ± 7 mmHg in angiotensin hypertension. Histological analysis demonstrated decreased injury to the juxtamedullary glomeruli. Renal expression of inflammatory genes was increased in angiotensin hypertension and two weeks of AR9281 treatment decreased this index of renal inflammation. Vascular function in angiotensin hypertension was also improved by AR9281 treatment. Decreased afferent arteriolar and mesenteric resistance endothelial dependent dilator responses were ameliorated by AR9281 treatment of angiotensin hypertensive rats. These data demonstrate that the first-in-class sEHI, AR9281, lowers blood pressure, improves vascular function and reduces renal damage in angiotensin hypertension.

Reversing Period-Doubling Bifurcations in Models of Population Interactions Using Constant Stocking or Harvesting

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James F. Selgrade; James H. Roberds

1998-01-01

This study considers a general class of two-dimensional, discrete population models where each per capita transition function (fitness) depends on a linear combination of the densities of the interacting populations. The fitness functions are either monotone decreasing functions (pioneer fitnesses) or one-humped functions (climax fitnesses). Conditions are derived...

Longitudinal Lung Function Decrease in Subjects with Spontaneous Healed Pulmonary Tuberculosis.

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Lee, Seung Heon; Kwon, Amy M; Yang, Hae-Chung; Lee, Seung Ku; Kim, Young; Choi, Jong Hyun; Kim, Je Hyeong; Shin, Chol

2016-01-01

We compared the longitudinal course of post-bronchodilator Forced Expiratory Volume in 1 second (pFEV1) over a 10-year period in subjects with spontaneous healed pulmonary tuberculosis (SHPTB) with that in normal subjects. We prospectively investigated 339 subjects with SHPTB and 3211 normal subjects. pFEV1 values measured biannually over 10 years were analyzed using mixed effects model. At baseline, there were no differences in gender, smoking amount, and mean height, except mean age (50.0 ± 8.1 VS. 48.1 ± 7.3, P< 0.001) between the SHPTB and normal group. 52% of the 339 participants with SHPTB and 56% of the 3211 normal participants participated till the end of study. According to the final model, the SHPTB group showed significantly larger decrease in the average pFEV1 over the time than the normal group (P< 0.001) adjusted for gender, age, height, smoking pack years, and time effects. Especially, the interaction effect between time and group was statistically significant (P = 0.036). The average lung function in terms of pFEV1 decreases faster in subjects with SHPTB than in normal individuals over time.

Decreased IGF-1 concentration during the first trimester of pregnancy in women with normal somatotroph function.

Science.gov (United States)

Persechini, Marie-Laure; Gennero, Isabelle; Grunenwald, Solange; Vezzosi, Delphine; Bennet, Antoine; Caron, Philippe

2015-08-01

A decrease of insulin-like growth factor-I levels (IGF-I) has been reported during the first trimester of pregnancy in women with acromegaly before the secretion of placental growth hormone (GH) progressively increases IGF-1 concentration. To evaluate variations of concentrations of IGF-1, insulin-like growth factor (IGF)-binding protein-3 (IGF-BP3) and GH during the first trimester of pregnancy in women with normal somatotroph function. Sixteen women (median age 31 years) with as who were followed for benign thyroid disorders (n = 15) or prolactin-secreting microadenoma (n = 1) were evaluated before and in the first trimester of pregnancy. Serum concentrations of GH, IGF-1, IGF-BP3, TSH and estradiol (E2) were measured before and in the first trimester (5.4 ± 2.2 weeks of gestation). Before pregnancy, somatotroph and thyroid functions (median TSH 1.2 mU/L) were normal in all women. At the first trimester IGF-1 levels decreased significantly (before = 210 ng/mL, first trimester = 145 ng/mL, p function, IGF-1 levels decrease in the first trimester of pregnancy without changes in GH or IGF-BP3 levels. These results confirm liver resistance to GH as a consequence of the physiological increase of estrogens during the first trimester.

Influence of pores on crack initiation in monotonic tensile and cyclic loadings in lost foam casting A319 alloy by using 3D in-situ analysis

International Nuclear Information System (INIS)

Wang, Long; Limodin, Nathalie; El Bartali, Ahmed; Witz, Jean-François; Seghir, Rian; Buffiere, Jean-Yves; Charkaluk, Eric

2016-01-01

Lost Foam Casting (LFC) process is replacing the conventional gravity Die Casting (DC) process in automotive industry for the purpose of geometry optimization, cost reduction and consumption control. However, due to lower cooling rate, LFC produces in a coarser microstructure that reduces fatigue life. In order to study the influence of the casting microstructure of LFC Al-Si alloy on damage micromechanisms under monotonic tensile loading and Low Cycle Fatigue (LCF) at room temperature, an experimental protocol based on the three dimensional (3D) in-situ analysis has been set up and validated. This paper focuses on the influence of pores on crack initiation in monotonic and cyclic tensile loadings. X-ray Computed Tomography (CT) allowed the microstructure of material being characterized in 3D and damage evolution being followed in-situ also in 3D. Experimental and numerical mechanical fields were obtained by using Digital Volume Correlation (DVC) technique and Finite Element Method (FEM) simulation respectively. Pores were shown to have an important influence on strain localization as large pores generate enough strain localization zones for crack initiation both in monotonic tensile and cyclic loadings.

Influence of pores on crack initiation in monotonic tensile and cyclic loadings in lost foam casting A319 alloy by using 3D in-situ analysis

Energy Technology Data Exchange (ETDEWEB)

Wang, Long, E-mail: longwang_calt@163.com [Univ. Lille, CNRS, Centrale Lille, Arts et Metiers Paris tech, FRE 3723 – LML – Laboratoire de Mecanique de Lille, F-59000 Lille (France); Limodin, Nathalie; El Bartali, Ahmed; Witz, Jean-François; Seghir, Rian [Univ. Lille, CNRS, Centrale Lille, Arts et Metiers Paris tech, FRE 3723 – LML – Laboratoire de Mecanique de Lille, F-59000 Lille (France); Buffiere, Jean-Yves [Laboratoire Matériaux, Ingénierie et Sciences (MATEIS), CNRS UMR5510, INSA-Lyon, 20 Av. Albert Einstein, 69621 Villeurbanne (France); Charkaluk, Eric [Univ. Lille, CNRS, Centrale Lille, Arts et Metiers Paris tech, FRE 3723 – LML – Laboratoire de Mecanique de Lille, F-59000 Lille (France)

2016-09-15

Lost Foam Casting (LFC) process is replacing the conventional gravity Die Casting (DC) process in automotive industry for the purpose of geometry optimization, cost reduction and consumption control. However, due to lower cooling rate, LFC produces in a coarser microstructure that reduces fatigue life. In order to study the influence of the casting microstructure of LFC Al-Si alloy on damage micromechanisms under monotonic tensile loading and Low Cycle Fatigue (LCF) at room temperature, an experimental protocol based on the three dimensional (3D) in-situ analysis has been set up and validated. This paper focuses on the influence of pores on crack initiation in monotonic and cyclic tensile loadings. X-ray Computed Tomography (CT) allowed the microstructure of material being characterized in 3D and damage evolution being followed in-situ also in 3D. Experimental and numerical mechanical fields were obtained by using Digital Volume Correlation (DVC) technique and Finite Element Method (FEM) simulation respectively. Pores were shown to have an important influence on strain localization as large pores generate enough strain localization zones for crack initiation both in monotonic tensile and cyclic loadings.

Behaviour of smart reinforced concrete beam with super elastic shape memory alloy subjected to monotonic loading

Science.gov (United States)

Hamid, Nubailah Abd; Ibrahim, Azmi; Adnan, Azlan; Ismail, Muhammad Hussain

2018-05-01

This paper discusses the superelastic behavior of shape memory alloy, NiTi when used as reinforcement in concrete beams. The ability of NiTi to recover and reduce permanent deformations of concrete beams was investigated. Small-scale concrete beams, with NiTi reinforcement were experimentally investigated under monotonic loads. The behaviour of simply supported reinforced concrete (RC) beams hybrid with NiTi rebars and the control beam subject to monotonic loads were experimentally investigated. This paper is to highlight the ability of the SMA bars to recover and reduce permanent deformations of concrete flexural members. The size of the control beam is 125 mm × 270 mm × 1000 mm with 3 numbers of 12 mm diameter bars as main reinforcement for compression and 3 numbers of 12 mm bars as tension or hanger bars while 6 mm diameter at 100 mm c/c used as shear reinforcement bars for control beam respectively. While, the minimal provision of 200mm using the 12.7mm of superelastic Shape Memory Alloys were employed to replace the steel rebar at the critical region of the beam. In conclusion, the contribution of the SMA bar in combination with high-strength steel to the conventional reinforcement showed that the SMA beam has exhibited an improve performance in term of better crack recovery and deformation. Therefore the usage of hybrid NiTi with the steel can substantially diminish the risk of the earthquake and also can reduce the associated cost aftermath.

Loschmidt echo for local perturbations: non-monotonic cross-over from the Fermi-golden-rule to the escape-rate regime

International Nuclear Information System (INIS)

Goussev, Arseni; Waltner, Daniel; Richter, Klaus; Jalabert, Rodolfo A

2008-01-01

We address the sensitivity of quantum mechanical time evolution by considering the time decay of the Loschmidt echo (LE) (or fidelity) for local perturbations of the Hamiltonian. Within a semiclassical approach, we derive analytical expressions for the LE decay for chaotic systems for the whole range from weak to strong local perturbations and identify different decay regimes which complement those known for the case of global perturbations. For weak perturbations, a Fermi-golden-rule (FGR)-type behavior is recovered. For strong perturbations, the escape-rate regime is reached, where the LE decays exponentially with a rate independent of the perturbation strength. The transition between the FGR regime and the escape-rate regime is non-monotonic, i.e. the rate of the exponential time-decay of the LE oscillates as a function of the perturbation strength. We further perform extensive quantum mechanical calculations of the LE based on numerical wave packet evolution, which strongly support our semiclassical theory. Finally, we discuss in some detail possible experimental realizations for observing the predicted behavior of the LE

Operations Between Functions

DEFF Research Database (Denmark)

Gardner, Richard J.; Kiderlen, Markus

A structural theory of operations between real-valued (or extended-real-valued) functions on a nonempty subset A of Rn is initiated. It is shown, for example, that any operation ∗ on a cone of functions containing the constant functions, which is pointwise, positively homogeneous, monotonic......, and associative, must be one of 40 explicitly given types. In particular, this is the case for operations between pairs of arbitrary, or continuous, or differentiable functions. The term pointwise means that (f ∗g)(x) = F(f(x), g(x)), for all x ∈ A and some function F of two variables. Several results in the same...... spirit are obtained for operations between convex functions or between support functions. For example, it is shown that ordinary addition is the unique pointwise operation between convex functions satisfying the identity property, i.e., f ∗ 0 = 0 ∗ f = f, for all convex f, while other results classify Lp...

Assessing dose-response relationships for endocrine disrupting chemicals (EDCs): a focus on non-monotonicity.

Science.gov (United States)

Zoeller, R Thomas; Vandenberg, Laura N

2015-05-15

The fundamental principle in regulatory toxicology is that all chemicals are toxic and that the severity of effect is proportional to the exposure level. An ancillary assumption is that there are no effects at exposures below the lowest observed adverse effect level (LOAEL), either because no effects exist or because they are not statistically resolvable, implying that they would not be adverse. Chemicals that interfere with hormones violate these principles in two important ways: dose-response relationships can be non-monotonic, which have been reported in hundreds of studies of endocrine disrupting chemicals (EDCs); and effects are often observed below the LOAEL, including all environmental epidemiological studies examining EDCs. In recognition of the importance of this issue, Lagarde et al. have published the first proposal to qualitatively assess non-monotonic dose response (NMDR) relationships for use in risk assessments. Their proposal represents a significant step forward in the evaluation of complex datasets for use in risk assessments. Here, we comment on three elements of the Lagarde proposal that we feel need to be assessed more critically and present our arguments: 1) the use of Klimisch scores to evaluate study quality, 2) the concept of evaluating study quality without topical experts' knowledge and opinions, and 3) the requirement of establishing the biological plausibility of an NMDR before consideration for use in risk assessment. We present evidence-based logical arguments that 1) the use of the Klimisch score should be abandoned for assessing study quality; 2) evaluating study quality requires experts in the specific field; and 3) an understanding of mechanisms should not be required to accept observable, statistically valid phenomena. It is our hope to contribute to the important and ongoing debate about the impact of NMDRs on risk assessment with positive suggestions.

Statistics of semiflexible self-avoiding trails on a family of two-dimensional compact fractals

International Nuclear Information System (INIS)

Živić, I; Elezović-Hadžić, S; Milošević, S

2011-01-01

We have applied the exact and Monte Carlo renormalization group (MCRG) method to study the statistics of semiflexible self-avoiding trails (SATs) on the family of plane-filling (PF) fractals. Each fractal of the family is compact, that is, the fractal dimension d f is equal to 2 for all members of the PF family, which are enumerated by an odd integer b, 3≤b<∞. Varying values of the stiffness parameter s of trails from 1 to 0 (so that when s decreases the trail stiffness increases) we calculate exactly (for 3 ≤ b ≤ 7) and through the MCRG approach (for b ≤ 201) the sets of the critical exponents ν (associated with the mean squared end-to-end distances of SATs) and γ (associated with the total number of different SATs). Our results show that critical exponents are stiffness dependent functions, so that ν(s) is a monotonically decreasing function of s, for each studied b, whereas γ(s) displays a non-monotonic behavior for some values of b. On the other hand, by fixing the stiffness parameter s, our results show clearly that for highly flexible trails (with s = 1 and 0.9) ν is a non-monotonic function of b, while for stiffer SATs (with s ≤ 0.7) ν monotonically decreases with b. We also show that γ(b) increases with increasing b, independently of s. Finally, we compare the obtained SAT data with those obtained for the semiflexible self-avoiding walk (SAW) model on the same fractal family, and for both models we discuss behavior of the studied exponents in the fractal-to-Euclidean crossover region b→∞

Marginal Consistency: Upper-Bounding Partition Functions over Commutative Semirings.

Science.gov (United States)

Werner, Tomás

2015-07-01

Many inference tasks in pattern recognition and artificial intelligence lead to partition functions in which addition and multiplication are abstract binary operations forming a commutative semiring. By generalizing max-sum diffusion (one of convergent message passing algorithms for approximate MAP inference in graphical models), we propose an iterative algorithm to upper bound such partition functions over commutative semirings. The iteration of the algorithm is remarkably simple: change any two factors of the partition function such that their product remains the same and their overlapping marginals become equal. In many commutative semirings, repeating this iteration for different pairs of factors converges to a fixed point when the overlapping marginals of every pair of factors coincide. We call this state marginal consistency. During that, an upper bound on the partition function monotonically decreases. This abstract algorithm unifies several existing algorithms, including max-sum diffusion and basic constraint propagation (or local consistency) algorithms in constraint programming. We further construct a hierarchy of marginal consistencies of increasingly higher levels and show than any such level can be enforced by adding identity factors of higher arity (order). Finally, we discuss instances of the framework for several semirings, including the distributive lattice and the max-sum and sum-product semirings.

Tuning Monotonic Basin Hopping: Improving the Efficiency of Stochastic Search as Applied to Low-Thrust Trajectory Optimization

Science.gov (United States)

Englander, Jacob A.; Englander, Arnold C.

2014-01-01

Trajectory optimization methods using monotonic basin hopping (MBH) have become well developed during the past decade [1, 2, 3, 4, 5, 6]. An essential component of MBH is a controlled random search through the multi-dimensional space of possible solutions. Historically, the randomness has been generated by drawing random variable (RV)s from a uniform probability distribution. Here, we investigate the generating the randomness by drawing the RVs from Cauchy and Pareto distributions, chosen because of their characteristic long tails. We demonstrate that using Cauchy distributions (as first suggested by J. Englander [3, 6]) significantly improves monotonic basin hopping (MBH) performance, and that Pareto distributions provide even greater improvements. Improved performance is defined in terms of efficiency and robustness. Efficiency is finding better solutions in less time. Robustness is efficiency that is undiminished by (a) the boundary conditions and internal constraints of the optimization problem being solved, and (b) by variations in the parameters of the probability distribution. Robustness is important for achieving performance improvements that are not problem specific. In this work we show that the performance improvements are the result of how these long-tailed distributions enable MBH to search the solution space faster and more thoroughly. In developing this explanation, we use the concepts of sub-diffusive, normally-diffusive, and super-diffusive random walks (RWs) originally developed in the field of statistical physics.

Coldest Temperature Extreme Monotonically Increased and Hottest Extreme Oscillated over Northern Hemisphere Land during Last 114 Years.

Science.gov (United States)

Zhou, Chunlüe; Wang, Kaicun

2016-05-13

Most studies on global warming rely on global mean surface temperature, whose change is jointly determined by anthropogenic greenhouse gases (GHGs) and natural variability. This introduces a heated debate on whether there is a recent warming hiatus and what caused the hiatus. Here, we presented a novel method and applied it to a 5° × 5° grid of Northern Hemisphere land for the period 1900 to 2013. Our results show that the coldest 5% of minimum temperature anomalies (the coldest deviation) have increased monotonically by 0.22 °C/decade, which reflects well the elevated anthropogenic GHG effect. The warmest 5% of maximum temperature anomalies (the warmest deviation), however, display a significant oscillation following the Atlantic Multidecadal Oscillation (AMO), with a warming rate of 0.07 °C/decade from 1900 to 2013. The warmest (0.34 °C/decade) and coldest deviations (0.25 °C/decade) increased at much higher rates over the most recent decade than last century mean values, indicating the hiatus should not be interpreted as a general slowing of climate change. The significant oscillation of the warmest deviation provides an extension of previous study reporting no pause in the hottest temperature extremes since 1979, and first uncovers its increase from 1900 to 1939 and decrease from 1940 to 1969.

Methyl-parathion decreases sperm function and fertilization capacity after targeting spermatocytes and maturing spermatozoa

International Nuclear Information System (INIS)

Pina-Guzman, B.; Sanchez-Gutierrez, M.; Marchetti, F.; Hernandez-Ochoa, I.; Solis-Heredia, M.J.; Quintanilla-Vega, B.

2009-01-01

Paternal germline exposure to organophosphorous pesticides (OP) has been associated with reproductive failures and adverse effects in the offspring. Methyl-parathion (Me-Pa), a worldwide-used OP, has reproductive adverse effects and is genotoxic to sperm, possibly via oxidative damage. This study investigated the stages of spermatogenesis susceptible to be targeted by Me-Pa exposure that impact on spermatozoa function and their ability to fertilize. Male mice were exposed to Me-Pa (20 mg/kg bw, i.p.) and spermatozoa from epididymis-vas deferens were collected at 7 or 28 days post-treatment (dpt) to assess the effects on maturing spermatozoa and spermatocytes, respectively. Spermatozoa were examined for DNA damage by nick translation (NT-positive cells) and SCSA (%DFI), lipoperoxidation (LPO) by malondialdehyde production, sperm function by spontaneous- and induced-acrosome reactions (AR), mitochondrial membrane potential (MMP) by using the JC-1 fluorochrome, and fertilization ability by an in vitro assay and in vivo mating. Alterations on DNA integrity (%DFI and NT-positive cells) in spermatozoa collected at 7 and 28 dpt, and decreases in sperm quality and induced-AR were observed; reduced MMP and LPO were observed at 7 dpt only. Negative correlations between LPO and sperm alterations were found. Altered sperm functional parameters evaluated either in vitro or in vivo were associated with reduced fertilization rates at both times. These results show that Me-Pa exposure of maturing spermatozoa and spermatocytes affects many sperm functional parameters that result in a decreased fertilizing capacity. Oxidative stress seems to be a likely mechanism of the detrimental effects of Me-Pa exposure in male germ cells.

Decreased functional connectivity of the amygdala in Alzheimer's disease revealed by resting-state fMRI

Energy Technology Data Exchange (ETDEWEB)

Yao, Hongxiang [Department of Radiology, Chinese PLA General Hospital, Beijing, 100853 (China); Liu, Yong, E-mail: yliu@nlpr.ia.ac.cn [Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190 (China); National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190 (China); Zhou, Bo; Zhang, Zengqiang [Department of Neurology, Institute of Geriatrics and Gerontology, Chinese PLA General Hospital, Beijing, 100853 (China); An, Ningyu [Department of Radiology, Chinese PLA General Hospital, Beijing, 100853 (China); Wang, Pan; Wang, Luning [Department of Neurology, Institute of Geriatrics and Gerontology, Chinese PLA General Hospital, Beijing, 100853 (China); Zhang, Xi, E-mail: zhangxi@301hospital.com.cn [Department of Neurology, Institute of Geriatrics and Gerontology, Chinese PLA General Hospital, Beijing, 100853 (China); Jiang, Tianzi [Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190 (China); National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190 (China); Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054 (China); The Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072 (Australia)

2013-09-15

Alzheimer's disease (AD), the most common cause of dementia, is thought to be a progressive neurodegenerative disease that is clinically characterised by a decline of memory and other cognitive functions. Mild cognitive impairment (MCI) is considered to be the prodromal stage of AD. However, the relationship between AD and MCI and the development process remains unclear. The amygdala is one of the most vulnerable structures in the early stages of AD. To our knowledge, this is the first report on the alteration of the functional connectivity of the amygdala in AD and MCI subjects. We hypothesised that the amygdala-cortical loop is impaired in AD and that these alterations relate to the disease severity. In our study, we used resting-state functional MRIs to investigate the altered amygdala connectivity patterns in 35 AD patients, 27 MCI patients and 27 age- and gender-matched normal controls (NC). Compared with the NC, the decreased functional connectivity found in the AD patients was mainly located between the amygdala and the regions that are included in the default mode, context conditioning and extinction networks. Importantly, the decreased functional connectivity between the amygdala and some of the identified regions was positively correlated with MMSE, which indicated that the cognitive function impairment is related to an altered functional connectivity pattern.

Decreased functional connectivity of the amygdala in Alzheimer's disease revealed by resting-state fMRI

International Nuclear Information System (INIS)

Yao, Hongxiang; Liu, Yong; Zhou, Bo; Zhang, Zengqiang; An, Ningyu; Wang, Pan; Wang, Luning; Zhang, Xi; Jiang, Tianzi

2013-01-01

Alzheimer's disease (AD), the most common cause of dementia, is thought to be a progressive neurodegenerative disease that is clinically characterised by a decline of memory and other cognitive functions. Mild cognitive impairment (MCI) is considered to be the prodromal stage of AD. However, the relationship between AD and MCI and the development process remains unclear. The amygdala is one of the most vulnerable structures in the early stages of AD. To our knowledge, this is the first report on the alteration of the functional connectivity of the amygdala in AD and MCI subjects. We hypothesised that the amygdala-cortical loop is impaired in AD and that these alterations relate to the disease severity. In our study, we used resting-state functional MRIs to investigate the altered amygdala connectivity patterns in 35 AD patients, 27 MCI patients and 27 age- and gender-matched normal controls (NC). Compared with the NC, the decreased functional connectivity found in the AD patients was mainly located between the amygdala and the regions that are included in the default mode, context conditioning and extinction networks. Importantly, the decreased functional connectivity between the amygdala and some of the identified regions was positively correlated with MMSE, which indicated that the cognitive function impairment is related to an altered functional connectivity pattern

Methods and Algorithms for Approximating the Gamma Function and Related Functions. A survey. Part I: Asymptotic Series

Directory of Open Access Journals (Sweden)

Cristinel Mortici

2015-01-01

Full Text Available In this survey we present our recent results on analysis of gamma function and related functions. The results obtained are in the theory of asymptotic analysis, approximation of gamma and polygamma functions, or in the theory of completely monotonic functions. The motivation of this first part is the work of C. Mortici [Product Approximations via Asymptotic Integration Amer. Math. Monthly 117 (2010 434-441] where a simple strategy for constructing asymptotic series is presented. The classical asymptotic series associated to Stirling, Wallis, Glaisher-Kinkelin are rediscovered. In the second section we discuss some new inequalities related to Landau constants and we establish some asymptotic formulas.

Decreased shoulder function and pain common in recreational badminton players.

Science.gov (United States)

Fahlström, M; Söderman, K

2007-06-01

The aim of this study was to describe the prevalence and consequences of painful conditions in the shoulder region in recreational badminton players. A questionnaire study was performed on 99 players, of whom 57 were also assessed with Constant score. Previous or present pain in the dominant shoulder was reported by 52% of the players. Sixteen percent of the players had on-going shoulder pain associated with badminton play. A majority of these players reported that their training habits were affected by the pain. Total Constant score was lower in the painful shoulders. Furthermore, range of active pain-free shoulder abduction was decreased. However, isometric shoulder strength test showed no differences when compared with pain-free shoulders. Even though the pain caused functional problems, the players were still playing with on-going symptoms. The diagnoses were mostly unknown, although history and clinical tests indicate problems resembling subacromial impingement.

Driving monotonous routes in a train simulator: the effect of task demand on driving performance and subjective experience.

Science.gov (United States)

Dunn, Naomi; Williamson, Ann

2012-01-01

Although monotony is widely recognised as being detrimental to performance, its occurrence and effects are not yet well understood. This is despite the fact that task-related characteristics, such as monotony and low task demand, have been shown to contribute to performance decrements over time. Participants completed one of two simulated train-driving scenarios. Both were highly monotonous and differed only in terms of the level of cognitive demand required (i.e. low demand or high demand). These results highlight the seriously detrimental effects of the combination of monotony and low task demands and clearly show that even a relatively minor increase in cognitive demand can mitigate adverse monotony-related effects on performance for extended periods of time. Monotony is an inherent characteristic of transport industries, including rail, aviation and road transport, which can have adverse impact on safety, reliability and efficiency. This study highlights possible strategies for mitigating these adverse effects. Practitioner Summary: This study provides evidence for the importance of cognitive demand in mitigating monotony-related effects on performance. The results have clear implications for the rapid onset of performance deterioration in low demand monotonous tasks and demonstrate that these detrimental performance effects can be overcome with simple solutions, such as making the task more cognitively engaging.

Some inequalities for the Bell numbers

Indian Academy of Sciences (India)

Feng Qi

2017-08-19

Aug 19, 2017 ... Bell number determinant; product; inequality; generating function; derivative; absolutely monotonic function; completely monotonic func- tion; logarithmically absolutely monotonic function; logarithmically completely monotonic function; Stirling number of the second kind; induction; Faà di Bruno formula;.

Using an inductive approach for definition making: Monotonicity and boundedness of sequences

Directory of Open Access Journals (Sweden)

Deonarain Brijlall

2009-09-01

Full Text Available The study investigated fourth–year students’ construction of the definitions of monotonicity and boundedness of sequences, at the Edgewood Campus of the University of KwaZulu –Natal in South Africa. Structured worksheets based on a guided problem solving teaching model were used to help students to construct the twodefinitions. A group of twenty three undergraduateteacher trainees participated in the project. These students specialised in the teaching of mathematics in the Further Education and Training (FET (Grades 10 to 12 school curriculum. This paper, specifically, reports on the investigation of students’ definition constructions based on a learnig theory within the context of advanced mathematical thinking and makes a contribution to an understanding of how these students constructed the two definitions. It was found that despite the intervention of a structured design, these definitions were partially or inadequately conceptualised by some students.

Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity.

Science.gov (United States)

Liu, Feng; Walters, Stephen J; Julious, Steven A

2017-10-02

It is important to quantify the dose response for a drug in phase 2a clinical trials so the optimal doses can then be selected for subsequent late phase trials. In a phase 2a clinical trial of new lead drug being developed for the treatment of rheumatoid arthritis (RA), a U-shaped dose response curve was observed. In the light of this result further research was undertaken to design an efficient phase 2a proof of concept (PoC) trial for a follow-on compound using the lessons learnt from the lead compound. The planned analysis for the Phase 2a trial for GSK123456 was a Bayesian Emax model which assumes the dose-response relationship follows a monotonic sigmoid "S" shaped curve. This model was found to be suboptimal to model the U-shaped dose response observed in the data from this trial and alternatives approaches were needed to be considered for the next compound for which a Normal dynamic linear model (NDLM) is proposed. This paper compares the statistical properties of the Bayesian Emax model and NDLM model and both models are evaluated using simulation in the context of adaptive Phase 2a PoC design under a variety of assumed dose response curves: linear, Emax model, U-shaped model, and flat response. It is shown that the NDLM method is flexible and can handle a wide variety of dose-responses, including monotonic and non-monotonic relationships. In comparison to the NDLM model the Emax model excelled with higher probability of selecting ED90 and smaller average sample size, when the true dose response followed Emax like curve. In addition, the type I error, probability of incorrectly concluding a drug may work when it does not, is inflated with the Bayesian NDLM model in all scenarios which would represent a development risk to pharmaceutical company. The bias, which is the difference between the estimated effect from the Emax and NDLM models and the simulated value, is comparable if the true dose response follows a placebo like curve, an Emax like curve, or log

Semiparametric Item Response Functions in the Context of Guessing

Science.gov (United States)

Falk, Carl F.; Cai, Li

2016-01-01

We present a logistic function of a monotonic polynomial with a lower asymptote, allowing additional flexibility beyond the three-parameter logistic model. We develop a maximum marginal likelihood-based approach to estimate the item parameters. The new item response model is demonstrated on math assessment data from a state, and a computationally…

Photoelectric work function measurement of a cesiated metal surface and its correlation with the surface-produced H- ion flux

International Nuclear Information System (INIS)

Wada, M.; Berkner, K.H.; Pyle, R.V.; Stearns, J.W.

1982-09-01

For application in plasma heating, fueling, and current drive of magnetic fusion devices, high current negative deuterium ion sources for intense neutral beam injectors are being developed using efficient production of negative hydrogen isotope ions on low work function metal surfaces imbedded in hydrogen plasmas. In order to investigate the correlation between work function and negative hydrogen ion production, photoelectron emission from a cesiated metal surface, which is immersed in a hydrogen plasma with an electron density less than 5 x 10 10 /cc, was measured in the photon energy range of 1.3 to 4.1 eV. The work function determination was based on Fowler's analysis, and at the optimum coverage a work function of less than 1.5 eV was observed for a Cs-Cu surface. Measured values of work functions for different Cs coverages were compared to the negative hydrogen currents produced at the metal surface in the discharge; the surface production of negative hydrogen ion current is monotonically increasing with decreasing work function

Solute-solvent cavity and bridge functions. I. Varying size of the solute

International Nuclear Information System (INIS)

Vyalov, I.; Chuev, G.; Georgi, N.

2014-01-01

In this work we present the results of the extensive molecular simulations of solute-solvent cavity and bridge functions. The mixtures of Lennard-Jones solvent with Lennard-Jones solute at infinite dilution are considered for different solute-solvent size ratios—up to 4:1. The Percus-Yevick and hypernetted chain closures deviate substantially from simulation results in the investigated temperature and density ranges. We also find that the behavior of the indirect and cavity correlation functions is non-monotonous within the hard-core region, but the latter can be successfully approximated by mean-field theory if the solute-solvent interaction energy is divided into repulsive and attractive contribution, according to Weeks-Chandler-Andersen theory. Furthermore, in spite of the non-monotonous behavior of logarithm of the cavity function and the indirect correlation function, their difference, i.e., the bridge function remains constant within the hard-core region. Such behavior of the bridge and indirect correlation functions at small distances and for small values of indirect correlation function is well known from the Duh-Haymet plots, where the non-unique relationship results in loops of the bridge function vs. indirect correlation function graphs. We show that the same pathological behavior appears also when distance is small and indirect correlation function is large. We further show that the unique functional behavior of the bridge function can be established when bridge is represented as a function of the renormalized, repulsive indirect correlation function

Decreasing relative risk premium

DEFF Research Database (Denmark)

Hansen, Frank

2007-01-01

such that the corresponding relative risk premium is a decreasing function of present wealth, and we determine the set of associated utility functions. We find a new characterization of risk vulnerability and determine a large set of utility functions, closed under summation and composition, which are both risk vulnerable...

Mental effort causes vigilance decrease due to resource depletion

NARCIS (Netherlands)

Smit, A.S.; Eling, P.A.T.M.; Coenen, A.M.L.

2004-01-01

The resource view on vigilance performance was tested. First, a low demanding task was compared with a similar low demanding task in which stimulus presentation was less monotonous due to added, irrelevant, stimuli. The resource view, maintaining that vigilance is lowered by hard mental work,

Asymptotic Poisson distribution for the number of system failures of a monotone system

International Nuclear Information System (INIS)

Aven, Terje; Haukis, Harald

1997-01-01

It is well known that for highly available monotone systems, the time to the first system failure is approximately exponentially distributed. Various normalising factors can be used as the parameter of the exponential distribution to ensure the asymptotic exponentiality. More generally, it can be shown that the number of system failures is asymptotic Poisson distributed. In this paper we study the performance of some of the normalising factors by using Monte Carlo simulation. The results show that the exponential/Poisson distribution gives in general very good approximations for highly available components. The asymptotic failure rate of the system gives best results when the process is in steady state, whereas other normalising factors seem preferable when the process is not in steady state. From a computational point of view the asymptotic system failure rate is most attractive

Non-monotonic spatial distribution of the interstellar dust in astrospheres: finite gyroradius effect

Science.gov (United States)

Katushkina, O. A.; Alexashov, D. B.; Izmodenov, V. V.; Gvaramadze, V. V.

2017-02-01

High-resolution mid-infrared observations of astrospheres show that many of them have filamentary (cirrus-like) structure. Using numerical models of dust dynamics in astrospheres, we suggest that their filamentary structure might be related to specific spatial distribution of the interstellar dust around the stars, caused by a gyrorotation of charged dust grains in the interstellar magnetic field. Our numerical model describes the dust dynamics in astrospheres under an influence of the Lorentz force and assumption of a constant dust charge. Calculations are performed for the dust grains with different sizes separately. It is shown that non-monotonic spatial dust distribution (viewed as filaments) appears for dust grains with the period of gyromotion comparable with the characteristic time-scale of the dust motion in the astrosphere. Numerical modelling demonstrates that the number of filaments depends on charge-to-mass ratio of dust.

Lidar inelastic multiple-scattering parameters of cirrus particle ensembles determined with geometrical-optics crystal phase functions.

Science.gov (United States)

Reichardt, J; Hess, M; Macke, A

2000-04-20

Multiple-scattering correction factors for cirrus particle extinction coefficients measured with Raman and high spectral resolution lidars are calculated with a radiative-transfer model. Cirrus particle-ensemble phase functions are computed from single-crystal phase functions derived in a geometrical-optics approximation. Seven crystal types are considered. In cirrus clouds with height-independent particle extinction coefficients the general pattern of the multiple-scattering parameters has a steep onset at cloud base with values of 0.5-0.7 followed by a gradual and monotonic decrease to 0.1-0.2 at cloud top. The larger the scattering particles are, the more gradual is the rate of decrease. Multiple-scattering parameters of complex crystals and of imperfect hexagonal columns and plates can be well approximated by those of projected-area equivalent ice spheres, whereas perfect hexagonal crystals show values as much as 70% higher than those of spheres. The dependencies of the multiple-scattering parameters on cirrus particle spectrum, base height, and geometric depth and on the lidar parameters laser wavelength and receiver field of view, are discussed, and a set of multiple-scattering parameter profiles for the correction of extinction measurements in homogeneous cirrus is provided.

Annealing temperature dependent non-monotonic d{sup 0} ferromagnetism in pristine In{sub 2}O{sub 3} nanoparticles

Energy Technology Data Exchange (ETDEWEB)

Cao, Haiming; Xing, Pengfei, E-mail: pfxing@tju.edu.cn; Yao, Dongsheng; Wu, Ping

2017-05-01

Cubic bixbyite In{sub 2}O{sub 3} nanoparticles with room temperature d{sup 0} ferromagnetism were prepared by sol-gel method with the air annealing temperature ranging from 500 to 900 °C. X-ray diffraction, X-ray photoelectron spectroscopy, Raman-scattering and photoluminescence were carried out to demonstrate the presence of oxygen vacancies. The lattice constant, the atomic ratio of crystal O and In, the Raman peak at 369 cm{sup −1}, the PL emission peak at 396 nm and the saturation magnetization of d{sup 0} ferromagnetism all had a consistent non-monotonic change with the increasing annealing temperature. With further considering the relation between the grain size and the distribution of oxygen vacancies, we think that d{sup 0} ferromagnetism in our samples is directly related with the singly charged oxygen vacancies at the surface of In{sub 2}O{sub 3} nanoparticles. - Highlights: • Effect of air-annealing temperature on the d{sup 0} ferromagnetism of pure In{sub 2}O{sub 3}. • Oxygen-deficiency states of all samples were detected by Raman scattering and PL. • Ferromagnetism changes non-monotonically with the increasing annealing temperature. • d{sup 0} ferromagnetism in our In{sub 2}O{sub 3} nanoparticles is related with the surface V{sub O}{sup +}.

Monotonic and cyclic responses of impact polypropylene and continuous glass fiber-reinforced impact polypropylene composites at different strain rates

KAUST Repository

Yudhanto, Arief

2016-03-08

Impact copolymer polypropylene (IPP), a blend of isotactic polypropylene and ethylene-propylene rubber, and its continuous glass fiber composite form (glass fiber-reinforced impact polypropylene, GFIPP) are promising materials for impact-prone automotive structures. However, basic mechanical properties and corresponding damage of IPP and GFIPP at different rates, which are of keen interest in the material development stage and numerical tool validation, have not been reported. Here, we applied monotonic and cyclic tensile loads to IPP and GFIPP at different strain rates (0.001/s, 0.01/s and 0.1/s) to study the mechanical properties, failure modes and the damage parameters. We used monotonic and cyclic tests to obtain mechanical properties and define damage parameters, respectively. We also used scanning electron microscopy (SEM) images to visualize the failure mode. We found that IPP generally exhibits brittle fracture (with relatively low failure strain of 2.69-3.74%) and viscoelastic-viscoplastic behavior. GFIPP [90]8 is generally insensitive to strain rate due to localized damage initiation mostly in the matrix phase leading to catastrophic transverse failure. In contrast, GFIPP [±45]s is sensitive to the strain rate as indicated by the change in shear modulus, shear strength and failure mode.

Mechanisms of information decoding in a cascade system of gene expression

Science.gov (United States)

Wang, Haohua; Yuan, Zhanjiang; Liu, Peijiang; Zhou, Tianshou

2016-05-01

Biotechnology advances have allowed investigation of heterogeneity of cellular responses to stimuli on the single-cell level. Functionally, this heterogeneity can compromise cellular responses to environmental signals, and it can also enlarge the repertoire of possible cellular responses and hence increase the adaptive nature of cellular behaviors. However, the mechanism of how this response heterogeneity is generated remains elusive. Here, by systematically analyzing a representative cellular signaling system, we show that (1) the upstream activator always amplifies the downstream burst frequency (BF) but the noiseless activator performs better than the noisy one, remarkably for small or moderate input signal strengths, and the repressor always reduces the downstream BF but the difference in the reducing effect between noiseless and noise repressors is very small; (2) both the downstream burst size and mRNA mean are a monotonically increasing function of the activator strength but a monotonically decreasing function of the repressor strength; (3) for repressor-type input, there is a noisy signal strength such that the downstream mRNA noise arrives at an optimal level, but for activator-type input, the output noise intensity is fundamentally a monotonically decreasing function of the input strength. Our results reveal the essential mechanisms of both signal information decoding and cellular response heterogeneity, whereas our analysis provides a paradigm for analyzing dynamics of noisy biochemical signaling systems.

Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity

Directory of Open Access Journals (Sweden)

Feng Liu

2017-10-01

Full Text Available Abstract Background It is important to quantify the dose response for a drug in phase 2a clinical trials so the optimal doses can then be selected for subsequent late phase trials. In a phase 2a clinical trial of new lead drug being developed for the treatment of rheumatoid arthritis (RA, a U-shaped dose response curve was observed. In the light of this result further research was undertaken to design an efficient phase 2a proof of concept (PoC trial for a follow-on compound using the lessons learnt from the lead compound. Methods The planned analysis for the Phase 2a trial for GSK123456 was a Bayesian Emax model which assumes the dose-response relationship follows a monotonic sigmoid “S” shaped curve. This model was found to be suboptimal to model the U-shaped dose response observed in the data from this trial and alternatives approaches were needed to be considered for the next compound for which a Normal dynamic linear model (NDLM is proposed. This paper compares the statistical properties of the Bayesian Emax model and NDLM model and both models are evaluated using simulation in the context of adaptive Phase 2a PoC design under a variety of assumed dose response curves: linear, Emax model, U-shaped model, and flat response. Results It is shown that the NDLM method is flexible and can handle a wide variety of dose-responses, including monotonic and non-monotonic relationships. In comparison to the NDLM model the Emax model excelled with higher probability of selecting ED90 and smaller average sample size, when the true dose response followed Emax like curve. In addition, the type I error, probability of incorrectly concluding a drug may work when it does not, is inflated with the Bayesian NDLM model in all scenarios which would represent a development risk to pharmaceutical company. The bias, which is the difference between the estimated effect from the Emax and NDLM models and the simulated value, is comparable if the true dose response

A Mixed Monotone Operator Method for the Existence and Uniqueness of Positive Solutions to Impulsive Caputo Fractional Differential Equations

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Jieming Zhang

2013-01-01

Full Text Available We establish some sufficient conditions for the existence and uniqueness of positive solutions to a class of initial value problem for impulsive fractional differential equations involving the Caputo fractional derivative. Our analysis relies on a fixed point theorem for mixed monotone operators. Our result can not only guarantee the existence of a unique positive solution but also be applied to construct an iterative scheme for approximating it. An example is given to illustrate our main result.

Exercise in claudicants increase or decrease walking ability and the response relates to mitochondrial function.

Science.gov (United States)

van Schaardenburgh, Michel; Wohlwend, Martin; Rognmo, Øivind; Mattsson, Erney J R

2017-06-07

Exercise of patients with intermittent claudication improves walking performance. Exercise does not usually increase blood flow, but seems to increase muscle mitochondrial enzyme activities. Although exercise is beneficial in most patients, it might be harmful in some. The mitochondrial response to exercise might therefore differ between patients. Our hypothesis was that changes in walking performance relate to changes in mitochondrial function after 8 weeks of exercise. At a subgroup level, negative responders decrease and positive responders increase mitochondrial capacity. Two types of exercise were studied, calf raising and walking (n = 28). We wanted to see whether there were negative and positive responders, independent of type of exercise. Measurements of walking performance, peripheral hemodynamics, mitochondrial respiration and content (citrate synthase activity) were obtained on each patient before and after the intervention period. Multiple linear regression was used to test whether changes in peak walking time relate to mitochondrial function. Subgroups of negative (n = 8) and positive responders (n = 8) were defined as those that either decreased or increased peak walking time following exercise. Paired t test and analysis of covariance was used to test changes within and between subgroups. Changes in peak walking time were related to changes in mitochondrial respiration supported by electron transferring flavoprotein (ETF + CI) P (p = 0.004), complex I (CI + ETF) P (p = 0.003), complex I + complex II (CI + CII + ETF) P (p = 0.037) and OXPHOS coupling efficiency (p = 0.046) in the whole group. Negative responders had more advanced peripheral arterial disease. Mitochondrial respiration supported by electron transferring flavoprotein (ETF + CI) P (p = 0.0013), complex I (CI + ETF) P (p = 0.0005), complex I + complex II (CI + CII + ETF) P (p = 0.011) and electron transfer system capacity (CI + CII + ETF) E (p

Behaviour of C-shaped angle shear connectors under monotonic and fully reversed cyclic loading: An experimental study

International Nuclear Information System (INIS)

Shariati, Mahdi; Ramli Sulong, N.H.; Suhatril, Meldi; Shariati, Ali; Arabnejad Khanouki, M.M.; Sinaei, Hamid

2012-01-01

Highlights: ► C-shaped angle connectors show 8.8–33.1% strength degradation under cyclic loading. ► Connector fracture type of failure was experienced in C-shaped angle shear connectors. ► In push-out samples, more cracking was observed in those slabs with longer angles. ► C-shaped angle connectors show good behaviour in terms of the ultimate shear capacity. ► C-shaped angle connectors did not fulfil the requirements for ductility criteria. -- Abstract: This paper presents an evaluation of the structural behaviour of C-shaped angle shear connectors in composite beams, suitable for transferring shear force in composite structures. The results of the experimental programme, including eight push-out tests, are presented and discussed. The results include resistance, strength degradation, ductility, and failure modes of C-shaped angle shear connectors, under monotonic and fully reversed cyclic loading. The results show that connector fracture type of failure was experienced in C-shaped angle connectors and after the failure, more cracking was observed in those slabs with longer angles. On top of that, by comparing the shear resistance of C-shaped angle shear connectors under monotonic and cyclic loading, these connectors showed 8.8–33.1% strength degradation, under fully reversed cyclic loading. Furthermore, it was concluded that the mentioned shear connector shows a proper behaviour, in terms of the ultimate shear capacity, but it does not satisfy the ductility criteria, imposed by the Eurocode 4, to perform a plastic distribution of the shear force between different connectors along the beam length.

On convergence of differential evolution over a class of continuous functions with unique global optimum.

Science.gov (United States)

Ghosh, Sayan; Das, Swagatam; Vasilakos, Athanasios V; Suresh, Kaushik

2012-02-01

Differential evolution (DE) is arguably one of the most powerful stochastic real-parameter optimization algorithms of current interest. Since its inception in the mid 1990s, DE has been finding many successful applications in real-world optimization problems from diverse domains of science and engineering. This paper takes a first significant step toward the convergence analysis of a canonical DE (DE/rand/1/bin) algorithm. It first deduces a time-recursive relationship for the probability density function (PDF) of the trial solutions, taking into consideration the DE-type mutation, crossover, and selection mechanisms. Then, by applying the concepts of Lyapunov stability theorems, it shows that as time approaches infinity, the PDF of the trial solutions concentrates narrowly around the global optimum of the objective function, assuming the shape of a Dirac delta distribution. Asymptotic convergence behavior of the population PDF is established by constructing a Lyapunov functional based on the PDF and showing that it monotonically decreases with time. The analysis is applicable to a class of continuous and real-valued objective functions that possesses a unique global optimum (but may have multiple local optima). Theoretical results have been substantiated with relevant computer simulations.

Decreased prefrontal functional brain response during memory testing in women with Cushing's syndrome in remission.

Science.gov (United States)

Ragnarsson, Oskar; Stomby, Andreas; Dahlqvist, Per; Evang, Johan A; Ryberg, Mats; Olsson, Tommy; Bollerslev, Jens; Nyberg, Lars; Johannsson, Gudmundur

2017-08-01

Neurocognitive dysfunction is an important feature of Cushing's syndrome (CS). Our hypothesis was that patients with CS in remission have decreased functional brain responses in the prefrontal cortex and hippocampus during memory testing. In this cross-sectional study we included 19 women previously treated for CS and 19 controls matched for age, gender, and education. The median remission time was 7 (IQR 6-10) years. Brain activity was studied with functional magnetic resonance imaging during episodic- and working-memory tasks. The primary regions of interest were the prefrontal cortex and the hippocampus. A voxel-wise comparison of functional brain responses in patients and controls was performed. During episodic-memory encoding, patients displayed lower functional brain responses in the left and right prefrontal gyrus (pright inferior occipital gyrus (pbrain responses in the left posterior hippocampus in patients (p=0.05). During episodic-memory retrieval, the patients displayed lower functional brain responses in several brain areas with the most predominant difference in the right prefrontal cortex (pbrain response during a more complex working memory task compared with a simpler one. In conclusion, women with CS in long-term remission have reduced functional brain responses during episodic and working memory testing. This observation extends previous findings showing long-term adverse effects of severe hypercortisolaemia on brain function. Copyright © 2017 Elsevier Ltd. All rights reserved.

Optimal investment and indifference pricing when risk aversion is not monotone: SAHARA utility functions

NARCIS (Netherlands)

Chen, A.; Pelsser, A.; Vellekoop, M.

2008-01-01

Abstract. We develop a new class of utility functions, SAHARA utility, with the dis- tinguishing feature that they implement the assumption that agents may become less risk-averse for very low values of wealth. This means that SAHARA utility can be used to characterize risk gambling behavior of an

Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function.

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Itay Shafat

Full Text Available Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate side chains, leading to structural modifications that loosen the extracellular matrix barrier and associated with tumor metastasis, inflammation and angiogenesis. In addition, the highly sulfated heparan sulfate proteoglycans are important constituents of the glomerular basement membrane and its permselective properties. Recent studies suggest a role for heparanase in several experimental and human glomerular diseases associated with proteinuria such as diabetes, minimal change disease, and membranous nephropathy. Here, we quantified blood and urine heparanase levels in renal transplant recipients and patients with chronic kidney disease (CKD, and assessed whether alterations in heparanase levels correlate with proteinuria and renal function. We report that in transplanted patients, urinary heparanase was markedly elevated, inversely associated with estimated glomerular filtration rate (eGFR, suggesting a relationship between heparanase and graft function. In CKD patients, urinary heparanase was markedly elevated and associated with proteinuria, but not with eGFR. In addition, urinary heparanase correlated significantly with plasma heparanase in transplanted patients. Such a systemic spread of heparanase may lead to damage of cells and tissues alongside the kidney.The newly described association between heparanase, proteinuria and decreased renal function is expected to pave the way for new therapeutic options aimed at attenuating chronic renal allograft nephropathy, leading to improved graft survival and patient outcome.

Non-monotonic reorganization of brain networks with Alzheimer’s disease progression

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Hyoungkyu eKim

2015-06-01

Full Text Available Background: Identification of stage-specific changes in brain network of patients with Alzheimer’s disease (AD is critical for rationally designed therapeutics that delays the progression of the disease. However, pathological neural processes and their resulting changes in brain network topology with disease progression are not clearly known. Methods: The current study was designed to investigate the alterations in network topology of resting state fMRI among patients in three different clinical dementia rating (CDR groups (i.e., CDR = 0.5, 1, 2 and amnestic mild cognitive impairment (aMCI and age-matched healthy subject groups. We constructed cost networks from these 5 groups and analyzed their network properties using graph theoretical measures.Results: The topological properties of AD brain networks differed in a non-monotonic, stage-specific manner. Interestingly, local and global efficiency and betweenness of the network were rather higher in the aMCI and AD (CDR 1 groups than those of prior stage groups. The number, location, and structure of rich-clubs changed dynamically as the disease progressed.Conclusions: The alterations in network topology of the brain are quite dynamic with AD progression, and these dynamic changes in network patterns should be considered meticulously for efficient therapeutic interventions of AD.

Polyhedral Lyapunov functions structurally ensure global asymptotic stability of dynamical networks iff the Jacobian is non-singular

NARCIS (Netherlands)

Blanchini, Franco; Giordano, G.

2017-01-01

For a vast class of dynamical networks, including chemical reaction networks (CRNs) with monotonic reaction rates, the existence of a polyhedral Lyapunov function (PLF) implies structural (i.e., parameter-free) local stability. Global structural stability is ensured under the additional

Experimental Studies on Behaviour of Reinforced Geopolymer Concrete Beams Subjected to Monotonic Static Loading

Science.gov (United States)

Madheswaran, C. K.; Ambily, P. S.; Dattatreya, J. K.; Ramesh, G.

2015-06-01

This work describes the experimental investigation on behaviour of reinforced GPC beams subjected to monotonic static loading. The overall dimensions of the GPC beams are 250 mm × 300 mm × 2200 mm. The effective span of beam is 1600 mm. The beams have been designed to be critical in shear as per IS:456 provisions. The specimens were produced from a mix incorporating fly ash and ground granulated blast furnace slag, which was designed for a compressive strength of 40 MPa at 28 days. The reinforced concrete specimens are subjected to curing at ambient temperature under wet burlap. The parameters being investigated include shear span to depth ratio (a/d = 1.5 and 2.0). Experiments are conducted on 12 GPC beams and four OPCC control beams. All the beams are tested using 2000 kN servo-controlled hydraulic actuator. This paper presents the results of experimental studies.

Non-Monotonic Relation Between Noise Exposure Severity and Neuronal Hyperactivity in the Auditory Midbrain

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Lara Li Hesse

2016-08-01

Full Text Available The occurrence of tinnitus can be linked to hearing loss in the majority of cases, but there is nevertheless a large degree of unexplained heterogeneity in the relation between hearing loss and tinnitus. Part of the problem might be that hearing loss is usually quantified in terms of increased hearing thresholds, which only provides limited information about the underlying cochlear damage. Moreover, noise exposure that does not cause hearing threshold loss can still lead to hidden hearing loss (HHL, i.e. functional deafferentation of auditory nerve fibres (ANFs through loss of synaptic ribbons in inner hair cells. Whilst it is known that increased hearing thresholds can trigger increases in spontaneous neural activity in the central auditory system, i.e. a putative neural correlate of tinnitus, the central effects of HHL have not yet been investigated. Here, we exposed mice to octave-band noise at 100 and 105 dB SPL, to generate HHL and permanent increases of hearing thresholds, respectively. Deafferentation of ANFs was confirmed through measurement of auditory brainstem responses and cochlear immunohistochemistry. Acute extracellular recordings from the auditory midbrain (inferior colliculus demonstrated increases in spontaneous neuronal activity (a putative neural correlate of tinnitus in both groups. Surprisingly the increase in spontaneous activity was most pronounced in the mice with HHL, suggesting that the relation between hearing loss and neuronal hyperactivity might be more complex than currently understood. Our computational model indicated that these differences in neuronal hyperactivity could arise from different degrees of deafferentation of low-threshold ANFs in the two exposure groups.Our results demonstrate that HHL is sufficient to induce changes in central auditory processing, and they also indicate a non-monotonic relationship between cochlear damage and neuronal hyperactivity, suggesting an explanation for why tinnitus might

Semi-Parametric Item Response Functions in the Context of Guessing. CRESST Report 844

Science.gov (United States)

Falk, Carl F.; Cai, Li

2015-01-01

We present a logistic function of a monotonic polynomial with a lower asymptote, allowing additional flexibility beyond the three-parameter logistic model. We develop a maximum marginal likelihood based approach to estimate the item parameters. The new item response model is demonstrated on math assessment data from a state, and a computationally…

Investigation on de-trapping mechanisms related to non-monotonic kink pattern in GaN HEMT devices

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Chandan Sharma

2017-08-01

Full Text Available This article reports an experimental approach to analyze the kink effect phenomenon which is usually observed during the GaN high electron mobility transistor (HEMT operation. De-trapping of charge carriers is one of the prominent reasons behind the kink effect. The commonly observed non-monotonic behavior of kink pattern is analyzed under two different device operating conditions and it is found that two different de-trapping mechanisms are responsible for a particular kink behavior. These different de-trapping mechanisms are investigated through a time delay analysis which shows the presence of traps with different time constants. Further voltage sweep and temperature analysis corroborates the finding that different de-trapping mechanisms play a role in kink behavior under different device operating conditions.

Investigation on de-trapping mechanisms related to non-monotonic kink pattern in GaN HEMT devices

Science.gov (United States)

Sharma, Chandan; Laishram, Robert; Amit, Rawal, Dipendra Singh; Vinayak, Seema; Singh, Rajendra

2017-08-01

This article reports an experimental approach to analyze the kink effect phenomenon which is usually observed during the GaN high electron mobility transistor (HEMT) operation. De-trapping of charge carriers is one of the prominent reasons behind the kink effect. The commonly observed non-monotonic behavior of kink pattern is analyzed under two different device operating conditions and it is found that two different de-trapping mechanisms are responsible for a particular kink behavior. These different de-trapping mechanisms are investigated through a time delay analysis which shows the presence of traps with different time constants. Further voltage sweep and temperature analysis corroborates the finding that different de-trapping mechanisms play a role in kink behavior under different device operating conditions.

Microstructure-based modelling of the long-term monotonic and cyclic creep of the martensitic steel X 20(22) CrMoV 12 1

International Nuclear Information System (INIS)

Henes, D.; Straub, S.; Blum, W.; Moehlig, H.; Granacher, J.; Berger, C.

1999-01-01

The current state of development of the composite model of deformation of the martensitic steel X 20(22) CrMoV 12 1 under conditions of creep is briefly described. The model is able to reproduce differences in monotonic creep strength of different melts with slightly different initial microstructures and to simulate cyclic creep with alternating phases of tension and compression. (orig.)

Structural analysis of reinforced concrete structures under monotonous and cyclic loadings: numerical aspects

International Nuclear Information System (INIS)

Lepretre, C.; Millard, A.; Nahas, G.

1989-01-01

The structural analysis of reinforced concrete structures is usually performed either by means of simplified methods of strength of materials type i.e. global methods, or by means of detailed methods of continuum mechanics type, i.e. local methods. For this second type, some constitutive models are available for concrete and rebars in a certain number of finite element systems. These models are often validated on simple homogeneous tests. Therefore, it is important to appraise the validity of the results when applying them to the analysis of a reinforced concrete structure, in order to be able to make correct predictions of the actual behaviour, under normal and faulty conditions. For this purpose, some tests have been performed at I.N.S.A. de Lyon on reinforced concrete beams, subjected to monotonous and cyclic loadings, in order to generate reference solutions to be compared with the numerical predictions given by two finite element systems: - CASTEM, developed by C.E.A./.D.E.M.T. - ELEFINI, developed by I.N.S.A. de Lyon

Asymmetric modes and complex time eigenvalues of the one-speed neutron transport equation in a homogeneous sphere

International Nuclear Information System (INIS)

Paranjape, S.D.; Kumar, V.; Sahni, D.C.

1993-01-01

The one-speed, time-dependent, isotropically scattering, integral transport equation in a homogeneous sphere has been converted into a criticality-like problem by considering exponential time behaviour of the scalar flux. This criticality problem has been converted into a matrix eigenvalue problem using the Fourier transform technique. The time eigenvalues λ, which are complex in general, have been determined for spherically symmetric as well as asymmetric modes. For the former case, the real decay constants and the real parts of complex decay constants decrease monotonically with increasing system size and form two distinct families of single-valued functions. For the spherically asymmetric modes, certain new features emerge. The real decay constants are found to be multi-valued functions of system size and they do not always decrease monotonically with increasing system size. As the system size increases from zero onwards, the decay constants alternate between complex and real values and the real and complex decay constant curves interlace. (Author)

Discrete gradient methods for solving variational image regularisation models

International Nuclear Information System (INIS)

Grimm, V; McLachlan, Robert I; McLaren, David I; Quispel, G R W; Schönlieb, C-B

2017-01-01

Discrete gradient methods are well-known methods of geometric numerical integration, which preserve the dissipation of gradient systems. In this paper we show that this property of discrete gradient methods can be interesting in the context of variational models for image processing, that is where the processed image is computed as a minimiser of an energy functional. Numerical schemes for computing minimisers of such energies are desired to inherit the dissipative property of the gradient system associated to the energy and consequently guarantee a monotonic decrease of the energy along iterations, avoiding situations in which more computational work might lead to less optimal solutions. Under appropriate smoothness assumptions on the energy functional we prove that discrete gradient methods guarantee a monotonic decrease of the energy towards stationary states, and we promote their use in image processing by exhibiting experiments with convex and non-convex variational models for image deblurring, denoising, and inpainting. (paper)

Aerobic Swim Training Restores Aortic Endothelial Function by Decreasing Superoxide Levels in Spontaneously Hypertensive Rats

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Camila P. Jordão

Full Text Available OBJECTIVE: We aimed to determine whether aerobic training decreases superoxide levels, increases nitric oxide levels, and improves endothelium-dependent vasodilation in the aortas of spontaneously hypertensive rats. METHODS: Spontaneously hypertensive rats (SHR and Wistar Kyoto rats (WKY were distributed into 2 groups: sedentary (SHRsd and WKYsd, n=10 each and swimming-trained (SHRtr, n=10 and WKYtr, n=10, respectively. The trained group participated in training sessions 5 days/week for 1 h/day with an additional work load of 4% of the animal’s body weight. After a 10-week sedentary or aerobic training period, the rats were euthanized. The thoracic aortas were removed to evaluate the vasodilator response to acetylcholine (10-10 to 10-4 M with or without preincubation with L-NG-nitro-L-arginine methyl ester hydrochloride (L-NAME; 10-4 M in vitro. The aortic tissue was also used to assess the levels of the endothelial nitric oxide synthase and nicotinamide adenine dinucleotide oxidase subunit isoforms 1 and 4 proteins, as well as the superoxide and nitrite contents. Blood pressure was measured using a computerized tail-cuff system. RESULTS: Aerobic training significantly increased the acetylcholine-induced maximum vasodilation observed in the SHRtr group compared with the SHRsd group (85.9±4.3 vs. 71.6±5.2%. Additionally, in the SHRtr group, superoxide levels were significantly decreased, nitric oxide bioavailability was improved, and the levels of the nicotinamide adenine dinucleotide oxidase subunit isoform 4 protein were decreased compared to the SHRsd group. Moreover, after training, the blood pressure of the SHRtr group decreased compared to the SHRsd group. Exercise training had no effect on the blood pressure of the WKYtr group. CONCLUSIONS: In SHR, aerobic swim training decreased vascular superoxide generation by nicotinamide adenine dinucleotide oxidase subunit isoform 4 and increased nitric oxide bioavailability, thereby improving

Oral nutritional support in malnourished elderly decreases functional limitations with no extra costs.

Science.gov (United States)

Neelemaat, Floor; Bosmans, Judith E; Thijs, Abel; Seidell, Jaap C; van Bokhorst-de van der Schueren, Marian A E

2012-04-01

Older people are vulnerable to malnutrition which leads to increased health care costs. The aim of this study was to evaluate the cost-effectiveness of nutritional supplementation from a societal perspective. This randomized controlled trial included hospital admitted malnourished elderly (≥ 60 y) patients. Patients in the intervention group received nutritional supplementation (energy and protein enriched diet, oral nutritional support, calcium-vitamin D supplement, telephone counselling by a dietician) until three months after discharge from hospital. Patients in the control group received usual care (control). Primary outcomes were Quality Adjusted Life Years (QALYs), physical activities and functional limitations. Measurements were performed at hospital admission and three months after discharge. Data were analyzed according to the intention-to-treat principle and multiple imputation was used to impute missing data. Incremental cost-effectiveness ratios were calculated and bootstrapping was applied to evaluate cost-effectiveness. Cost-effectiveness was expressed by cost-effectiveness planes and cost-effectiveness acceptability curves. 210 patients were included, 105 in each group. After three months, no statistically significant differences in quality of life and physical activities were observed between groups. Functional limitations decreased significantly more in the intervention group (mean difference -0.72, 95% CI-1.15; -0.28). There were no differences in costs between groups. Cost-effectiveness for QALYs and physical activities could not be demonstrated. For functional limitations we found a 0.95 probability that the intervention is cost-effective in comparison with usual care for ceiling ratios > €6500. A multi-component nutritional intervention to malnourished elderly patients for three months after hospital discharge leads to significant improvement in functional limitations and is neutral in costs. A follow-up of three months is probably too

Explosive percolation on directed networks due to monotonic flow of activity

Science.gov (United States)

Waagen, Alex; D'Souza, Raissa M.; Lu, Tsai-Ching

2017-07-01

An important class of real-world networks has directed edges, and in addition, some rank ordering on the nodes, for instance the popularity of users in online social networks. Yet, nearly all research related to explosive percolation has been restricted to undirected networks. Furthermore, information on such rank-ordered networks typically flows from higher-ranked to lower-ranked individuals, such as follower relations, replies, and retweets on Twitter. Here we introduce a simple percolation process on an ordered, directed network where edges are added monotonically with respect to the rank ordering. We show with a numerical approach that the emergence of a dominant strongly connected component appears to be discontinuous. Large-scale connectivity occurs at very high density compared with most percolation processes, and this holds not just for the strongly connected component structure but for the weakly connected component structure as well. We present analysis with branching processes, which explains this unusual behavior and gives basic intuition for the underlying mechanisms. We also show that before the emergence of a dominant strongly connected component, multiple giant strongly connected components may exist simultaneously. By adding a competitive percolation rule with a small bias to link uses of similar rank, we show this leads to formation of two distinct components, one of high-ranked users, and one of low-ranked users, with little flow between the two components.

Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice

Science.gov (United States)

Lin, Ai-Ling; Pulliam, Daniel A; Deepa, Sathyaseelan S; Halloran, Jonathan J; Hussong, Stacy A; Burbank, Raquel R; Bresnen, Andrew; Liu, Yuhong; Podlutskaya, Natalia; Soundararajan, Anuradha; Muir, Eric; Duong, Timothy Q; Bokov, Alex F; Viscomi, Carlo; Zeviani, Massimo; Richardson, Arlan G; Van Remmen, Holly; Fox, Peter T; Galvan, Veronica

2013-01-01

Recent studies have challenged the prevailing view that reduced mitochondrial function and increased oxidative stress are correlated with reduced longevity. Mice carrying a homozygous knockout (KO) of the Surf1 gene showed a significant decrease in mitochondrial electron transport chain Complex IV activity, yet displayed increased lifespan and reduced brain damage after excitotoxic insults. In the present study, we examined brain metabolism, brain hemodynamics, and memory of Surf1 KO mice using in vitro measures of mitochondrial function, in vivo neuroimaging, and behavioral testing. We show that decreased respiration and increased generation of hydrogen peroxide in isolated Surf1 KO brain mitochondria are associated with increased brain glucose metabolism, cerebral blood flow, and lactate levels, and with enhanced memory in Surf1 KO mice. These metabolic and functional changes in Surf1 KO brains were accompanied by higher levels of hypoxia-inducible factor 1 alpha, and by increases in the activated form of cyclic AMP response element-binding factor, which is integral to memory formation. These findings suggest that Surf1 deficiency-induced metabolic alterations may have positive effects on brain function. Exploring the relationship between mitochondrial activity, oxidative stress, and brain function will enhance our understanding of cognitive aging and of age-related neurologic disorders. PMID:23838831

Flicker sensitivity as a function of target area with and without temporal noise.

Science.gov (United States)

Rovamo, J; Donner, K; Näsänen, R; Raninen, A

2000-01-01

Flicker sensitivities (1-30 Hz) in foveal, photopic vision were measured as functions of stimulus area with and without strong external white temporal noise. Stimuli were circular, sinusoidally flickering sharp-edged spots of variable diameters (0.25-4 degrees ) but constant duration (2 s), surrounded by a uniform equiluminant field. The data was described with a model comprising (i) low-pass filtering in the retina (R), with a modulation transfer function (MTF) of a form derived from responses of cones; (ii) normalisation of the temporal luminance distribution by the average luminance; (iii) high-pass filtering by postreceptoral neural pathways (P), with an MTF proportional to temporal frequency; (iv) addition of internal white neural noise (N(i)); (v) integration over a spatial window; and (vi) detection by a suboptimal temporal matched filter of efficiency eta. In strong external noise, flicker sensitivity was independent of spot area. Without external noise, sensitivity increased with the square root of stimulus area (Piper's law) up to a critical area (A(c)), where it reaches a maximum level (S(max)). Both A(c) and eta were monotonic functions of temporal frequency (f), such that log A(c) increased and log eta decreased linearly with log f. Remarkably, the increase in spatial integration area and the decrease in efficiency were just balanced, so A(c)(f)eta(f) was invariant against f. Thus the bandpass characteristics of S(max)(f) directly reflected the composite effect of the distal filters R(f) and P(f). The temporal equivalent (N(it)) of internal neural noise (N(i)) decreased in inverse proportion to spot area up to A(c) and then stayed constant indicating that spatially homogeneous signals and noise are integrated over the same area.

Creep crack growth by grain boundary cavitation under monotonic and cyclic loading

Science.gov (United States)

Wen, Jian-Feng; Srivastava, Ankit; Benzerga, Amine; Tu, Shan-Tung; Needleman, Alan

2017-11-01

Plane strain finite deformation finite element calculations of mode I crack growth under small scale creep conditions are carried out. Attention is confined to isothermal conditions and two time histories of the applied stress intensity factor: (i) a monononic increase to a plateau value subsequently held fixed; and (ii) a cyclic time variation. The crack growth calculations are based on a micromechanics constitutive relation that couples creep deformation and damage due to grain boundary cavitation. Grain boundary cavitation, with cavity growth due to both creep and diffusion, is taken as the sole failure mechanism contributing to crack growth. The influence on the crack growth rate of loading history parameters, such as the magnitude of the applied stress intensity factor, the ratio of the applied minimum to maximum stress intensity factors, the loading rate, the hold time and the cyclic loading frequency, are explored. The crack growth rate under cyclic loading conditions is found to be greater than under monotonic creep loading with the plateau applied stress intensity factor equal to its maximum value under cyclic loading conditions. Several features of the crack growth behavior observed in creep-fatigue tests naturally emerge, for example, a Paris law type relation is obtained for cyclic loading.

A practical guide to averaging functions

CERN Document Server

Beliakov, Gleb; Calvo Sánchez, Tomasa

2016-01-01

This book offers an easy-to-use and practice-oriented reference guide to mathematical averages. It presents different ways of aggregating input values given on a numerical scale, and of choosing and/or constructing aggregating functions for specific applications. Building on a previous monograph by Beliakov et al. published by Springer in 2007, it outlines new aggregation methods developed in the interim, with a special focus on the topic of averaging aggregation functions. It examines recent advances in the field, such as aggregation on lattices, penalty-based aggregation and weakly monotone averaging, and extends many of the already existing methods, such as: ordered weighted averaging (OWA), fuzzy integrals and mixture functions. A substantial mathematical background is not called for, as all the relevant mathematical notions are explained here and reported on together with a wealth of graphical illustrations of distinct families of aggregation functions. The authors mainly focus on practical applications ...

Decreasing the Functioning Consumptions of Plastics Injection Moulding Machines

Science.gov (United States)

Vasilache, V.; Vasilache, M.; Vasilache, A.

2017-06-01

A share of about 75% in the cost of a plastic moulded part is held by the energy consumption of the injection machine. It is the heating system of the plasticising unit which is responsible for the energophague character of the process. The transfer rate from the heating elements to the plasticising cylinder depends hardly on the geometry of the system. A new heating system is designed, replacing the classical systems which are applied on the exterior of the cylinder with an “engrooved system”. Proposed heating system leads to decreasing of energy consumption up to 30 % and maintenance costs up to 10 %. A supplementary possibility to decrease the maintenance costs is to modify the geometry of the injection torpedo. The proposed geometry eliminates the possibility of any breaking or gripping related to the injection torpedo.

An inequality for convex functionals and its application to a maxwellian gas

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G. Toscani

1991-05-01

Full Text Available We study the trend towards equilibrium of the solution of the spatially homogeneous Boltzmann equation for a gas of Maxwellian molecules. The cases of axially symmetric and plane initial densities are investigated. In these situations, the strong L1 convergence to equilibrium follows by a suitable use of some convex and isotropic functionals, with monotonic behaviour in time along the solution. The initial density is required to have finite energy and entropy. It is shown that the functionals satisfy a common convolution inequality.

Resonant scattering of energetic electrons in the plasmasphere by monotonic whistler-mode waves artificially generated by ionospheric modification

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S. S. Chang

2014-05-01

Full Text Available Modulated high-frequency (HF heating of the ionosphere provides a feasible means of artificially generating extremely low-frequency (ELF/very low-frequency (VLF whistler waves, which can leak into the inner magnetosphere and contribute to resonant interactions with high-energy electrons in the plasmasphere. By ray tracing the magnetospheric propagation of ELF/VLF emissions artificially generated at low-invariant latitudes, we evaluate the relativistic electron resonant energies along the ray paths and show that propagating artificial ELF/VLF waves can resonate with electrons from ~ 100 keV to ~ 10 MeV. We further implement test particle simulations to investigate the effects of resonant scattering of energetic electrons due to triggered monotonic/single-frequency ELF/VLF waves. The results indicate that within the period of a resonance timescale, changes in electron pitch angle and kinetic energy are stochastic, and the overall effect is cumulative, that is, the changes averaged over all test electrons increase monotonically with time. The localized rates of wave-induced pitch-angle scattering and momentum diffusion in the plasmasphere are analyzed in detail for artificially generated ELF/VLF whistlers with an observable in situ amplitude of ~ 10 pT. While the local momentum diffusion of relativistic electrons is small, with a rate of −7 s−1, the local pitch-angle scattering can be intense near the loss cone with a rate of ~ 10−4 s−1. Our investigation further supports the feasibility of artificial triggering of ELF/VLF whistler waves for removal of high-energy electrons at lower L shells within the plasmasphere. Moreover, our test particle simulation results show quantitatively good agreement with quasi-linear diffusion coefficients, confirming the applicability of both methods to evaluate the resonant diffusion effect of artificial generated ELF/VLF whistlers.

Nonparametric Information Geometry: From Divergence Function to Referential-Representational Biduality on Statistical Manifolds

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Jun Zhang

2013-12-01

Full Text Available Divergence functions are the non-symmetric “distance” on the manifold, Μθ, of parametric probability density functions over a measure space, (Χ,μ. Classical information geometry prescribes, on Μθ: (i a Riemannian metric given by the Fisher information; (ii a pair of dual connections (giving rise to the family of α-connections that preserve the metric under parallel transport by their joint actions; and (iii a family of divergence functions ( α-divergence defined on Μθ x Μθ, which induce the metric and the dual connections. Here, we construct an extension of this differential geometric structure from Μθ (that of parametric probability density functions to the manifold, Μ, of non-parametric functions on X, removing the positivity and normalization constraints. The generalized Fisher information and α-connections on M are induced by an α-parameterized family of divergence functions, reflecting the fundamental convex inequality associated with any smooth and strictly convex function. The infinite-dimensional manifold, M, has zero curvature for all these α-connections; hence, the generally non-zero curvature of M can be interpreted as arising from an embedding of Μθ into Μ. Furthermore, when a parametric model (after a monotonic scaling forms an affine submanifold, its natural and expectation parameters form biorthogonal coordinates, and such a submanifold is dually flat for α = ± 1, generalizing the results of Amari’s α-embedding. The present analysis illuminates two different types of duality in information geometry, one concerning the referential status of a point (measurable function expressed in the divergence function (“referential duality” and the other concerning its representation under an arbitrary monotone scaling (“representational duality”.

Comparison of the monotonic and cyclic mechanical properties of ultrafine-grained low carbon steels processed by continuous and conventional equal channel angular pressing

International Nuclear Information System (INIS)

Niendorf, T.; Böhner, A.; Höppel, H.W.; Göken, M.; Valiev, R.Z.; Maier, H.J.

2013-01-01

Highlights: ► UFG low-carbon steel was successfully processed by continuous ECAP-Conform. ► Continuously processed UFG steel shows high performance. ► High monotonic strength and good ductility. ► Microstructural stability under cyclic loading in the LCF regime. ► Established concepts can be used for predicting the properties. - Abstract: In the current study the mechanical properties of ultra-fine grained low carbon steel processed by conventional equal channel angular pressing and a continuous equal channel angular pressing-Conform process were investigated. Both monotonic and cyclic properties were determined for the steel in either condition and found to be very similar. Microstructural analyses employing electron backscatter diffraction were used for comparison of the low carbon steels processed by either technique. Both steels feature very similar grain sizes and misorientation angle distributions. With respect to fatigue life the low carbon steel investigated shows properties similar to ultra-fine grained interstitial-free steel processed by conventional equal channel angular pressing, and thus, the general fatigue behavior can be addressed following the same routines as proposed for interstitial-free steel. In conclusion, the continuously processed material exhibits very promising properties, and thus, equal channel angular pressing-Conform is a promising tool for production of ultra-fine grained steels in a large quantity

The monotonicity rules for the ratio of two Laplace transforms with applications

OpenAIRE

Yang, Zhen-Hang; Tian, Jing-Feng

2018-01-01

Let $f$ and $g$ be both continuous functions on $\\left( 0,\\infty \\right) $ with $g\\left( t\\right) >0$ for $t\\in \\left( 0,\\infty \\right) $ and let $ F\\left( x\\right) =\\mathcal{L}\\left( f\\right) $, $G\\left( x\\right) =\\mathcal{L }\\left( g\\right) $ be respectively the Laplace transforms of $f$ and $g$ converging for $x>0$. We prove that if there is a $t^{\\ast }\\in \\left( 0,\\infty \\right) $ such that $f/g$ is strictly increasing on $\\left( 0,t^{\\ast }\\right) $ and strictly decreasing on $\\left( t^...

Auditory filters at low-frequencies

DEFF Research Database (Denmark)

Orellana, Carlos Andrés Jurado; Pedersen, Christian Sejer; Møller, Henrik

2009-01-01

-ear transfer function), the asymmetry of the auditory filter changed from steeper high-frequency slopes at 1000 Hz to steeper low-frequency slopes below 100 Hz. Increasing steepness at low-frequencies of the middle-ear high-pass filter is thought to cause this effect. The dynamic range of the auditory filter...... was found to steadily decrease with decreasing center frequency. Although the observed decrease in filter bandwidth with decreasing center frequency was only approximately monotonic, the preliminary data indicates the filter bandwidth does not stabilize around 100 Hz, e.g. it still decreases below...

First functional polymorphism in CFTR promoter that results in decreased transcriptional activity and Sp1/USF binding

International Nuclear Information System (INIS)

Taulan, M.; Lopez, E.; Guittard, C.; Rene, C.; Baux, D.; Altieri, J.P.; DesGeorges, M.; Claustres, M.; Romey, M.C.

2007-01-01

Growing evidences show that functionally relevant polymorphisms in various promoters alter both transcriptional activity and affinities of existing protein-DNA interactions, and thus influence disease progression in humans. We previously reported the -94G>T CFTR promoter variant in a female CF patient in whom any known disease-causing mutation has been detected. To investigate whether the -94G>T could be a regulatory variant, we have proceeded to in silico analyses and functional studies including EMSA and reporter gene assays. Our data indicate that the promoter variant decreases basal CFTR transcriptional activity in different epithelial cells and alters binding affinities of both Sp1 and USF nuclear proteins to the CFTR promoter. The present report provides evidence for the first functional polymorphism that negatively affects the CFTR transcriptional activity and demonstrates a cooperative role of Sp1 and USF transcription factors in transactivation of the CFTR gene promoter

Focus Article: Oscillatory and long-range monotonic exponential decays of electrostatic interactions in ionic liquids and other electrolytes: The significance of dielectric permittivity and renormalized charges

Science.gov (United States)

Kjellander, Roland

2018-05-01

A unified treatment of oscillatory and monotonic exponential decays of interactions in electrolytes is displayed, which highlights the role of dielectric response of the fluid in terms of renormalized (effective) dielectric permittivity and charges. An exact, but physically transparent statistical mechanical formalism is thereby used, which is presented in a systematic, pedagogical manner. Both the oscillatory and monotonic behaviors are given by an equation for the decay length of screened electrostatic interactions that is very similar to the classical expression for the Debye length. The renormalized dielectric permittivities, which have similar roles for electrolytes as the dielectric constant has for pure polar fluids, consist in general of several entities with different physical meanings. They are connected to dielectric response of the fluid on the same length scale as the decay length of the screened interactions. Only in cases where the decay length is very long, these permittivities correspond approximately to a dielectric response in the long-wavelength limit, like the dielectric constant for polar fluids. Experimentally observed long-range exponentially decaying surface forces are analyzed as well as the oscillatory forces observed for short to intermediate surface separations. Both occur in some ionic liquids and in concentrated as well as very dilute electrolyte solutions. The coexisting modes of decay are in general determined by the bulk properties of the fluid and not by the solvation of the surfaces; in the present cases, they are given by the behavior of the screened Coulomb interaction of the bulk fluid. The surface-fluid interactions influence the amplitudes and signs or phases of the different modes of the decay, but not their decay lengths and wavelengths. The similarities between some ionic liquids and very dilute electrolyte solutions as regards both the long-range monotonic and the oscillatory decays are analyzed.

The Sigmoid Transfer Function and the Gain-threshold Exponential Dependence for Neurons from Statistical Mechanics Treatment

Czech Academy of Sciences Publication Activity Database

Andrey, Ladislav; Erzan, R.

2002-01-01

Roč. 52, č. 12 (2002), s. 1349-1356 ISSN 0011-4626 R&D Projects: GA ČR GA305/02/1487 Institutional research plan: AV0Z1030915 Keywords : nonlinear gain curve * gain-threshold dependence * non-monotone transfer function * statistical mechanics Subject RIV: BA - General Mathematics Impact factor: 0.311, year: 2002

Local Monotonicity and Isoperimetric Inequality on Hypersurfaces in Carnot groups

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Francesco Paolo Montefalcone

2010-12-01

Full Text Available Let G be a k-step Carnot group of homogeneous dimension Q. Later on we shall present some of the results recently obtained in [32] and, in particular, an intrinsic isoperimetric inequality for a C2-smooth compact hypersurface S with boundary @S. We stress that S and @S are endowed with the homogeneous measures n????1 H and n????2 H , respectively, which are actually equivalent to the intrinsic (Q - 1-dimensional and (Q - 2-dimensional Hausdor measures with respect to a given homogeneous metric % on G. This result generalizes a classical inequality, involving the mean curvature of the hypersurface, proven by Michael and Simon [29] and Allard [1], independently. One may also deduce some related Sobolev-type inequalities. The strategy of the proof is inspired by the classical one and will be discussed at the rst section. After reminding some preliminary notions about Carnot groups, we shall begin by proving a linear isoperimetric inequality. The second step is a local monotonicity formula. Then we may achieve the proof by a covering argument.We stress however that there are many dierences, due to our non-Euclidean setting.Some of the tools developed ad hoc are, in order, a \\blow-up" theorem, which holds true also for characteristic points, and a smooth Coarea Formula for the HS-gradient. Other tools are the horizontal integration by parts formula and the 1st variation formula for the H-perimeter n????1H already developed in [30, 31] and then generalized to hypersurfaces having non-empty characteristic set in [32]. These results can be useful in the study of minimal and constant horizontal mean curvature hypersurfaces in Carnot groups.

Mechanical characteristics under monotonic and cyclic simple shear of spark plasma sintered ultrafine-grained nickel

International Nuclear Information System (INIS)

Dirras, G.; Bouvier, S.; Gubicza, J.; Hasni, B.; Szilagyi, T.

2009-01-01

The present work focuses on understanding the mechanical behavior of bulk ultrafine-grained nickel specimens processed by spark plasma sintering of high purity nickel nanopowder and subsequently deformed under large amplitude monotonic simple shear tests and strain-controlled cyclic simple shear tests at room temperature. During cyclic tests, the samples were deformed up to an accumulated von Mises strain of about ε VM = 0.75 (the flow stress was in the 650-700 MPa range), which is extremely high in comparison with the low tensile/compression ductility of this class of materials at quasi-static conditions. The underlying physical mechanisms were investigated by electron microscopy and X-ray diffraction profile analysis. Lattice dislocation-based plasticity leading to cell formation and dislocation interactions with twin boundaries contributed to the work-hardening of these materials. The large amount of plastic strain that has been reached during the shear tests highlights intrinsic mechanical characteristics of the ultrafine-grained nickel studied here.

Mechanical characteristics under monotonic and cyclic simple shear of spark plasma sintered ultrafine-grained nickel

Energy Technology Data Exchange (ETDEWEB)

Dirras, G., E-mail: dirras@univ-paris13.fr [LPMTM - CNRS, Institut Galilee, Universite Paris 13, 99 Avenue J.B. Clement, 93430 Villetaneuse (France); Bouvier, S. [LPMTM - CNRS, Institut Galilee, Universite Paris 13, 99 Avenue J.B. Clement, 93430 Villetaneuse (France); Gubicza, J. [Department of Materials Physics, Eoetvoes Lorand University, P.O.B. 32, Budapest H-1518 (Hungary); Hasni, B. [LPMTM - CNRS, Institut Galilee, Universite Paris 13, 99 Avenue J.B. Clement, 93430 Villetaneuse (France); Szilagyi, T. [Department of Materials Physics, Eoetvoes Lorand University, P.O.B. 32, Budapest H-1518 (Hungary)

2009-11-25

The present work focuses on understanding the mechanical behavior of bulk ultrafine-grained nickel specimens processed by spark plasma sintering of high purity nickel nanopowder and subsequently deformed under large amplitude monotonic simple shear tests and strain-controlled cyclic simple shear tests at room temperature. During cyclic tests, the samples were deformed up to an accumulated von Mises strain of about {epsilon}{sub VM} = 0.75 (the flow stress was in the 650-700 MPa range), which is extremely high in comparison with the low tensile/compression ductility of this class of materials at quasi-static conditions. The underlying physical mechanisms were investigated by electron microscopy and X-ray diffraction profile analysis. Lattice dislocation-based plasticity leading to cell formation and dislocation interactions with twin boundaries contributed to the work-hardening of these materials. The large amount of plastic strain that has been reached during the shear tests highlights intrinsic mechanical characteristics of the ultrafine-grained nickel studied here.

Immune activation is associated with decreased thymic function in ...

African Journals Online (AJOL)

Background: Reduced thymic function causes poor immunological reconstitution in human immunodeficiency virus (HIV)-positive patients on combined antiretroviral therapy (cART). The association between immune activation and thymic function in asymptomatic HIVpositive treatment-naive individuals has thus far not been ...

Implication from thyroid function decreasing during chemotherapy in breast cancer patients: chemosensitization role of triiodothyronine

Science.gov (United States)

2013-01-01

Background Thyroid hormones have been shown to regulate breast cancer cells growth, the absence or reduction of thyroid hormones in cells could provoke a proliferation arrest in G0-G1 or weak mitochondrial activity, which makes cells insensitive to therapies for cancers through transforming into low metabolism status. This biological phenomenon may help explain why treatment efficacy and prognosis vary among breast cancer patients having hypothyroid, hyperthyroid and normal function. Nevertheless, the abnormal thyroid function in breast cancer patients has been considered being mainly caused by thyroid diseases, few studied influence of chemotherapy on thyroid function and whether its alteration during chemotherapy can influence the respose to chemotherapy is still unclear. So, we aimed to find the alterations of thyroid function and non-thyroidal illness syndrome (NTIS) prevalence druing chemotherapy in breast cancer patients, and investigate the influence of thyroid hormones on chemotherapeutic efficacy. Methods Thyroid hormones and NTIS prevalence at initial diagnosis and during chemotherapy were analyzed in 685 breast diseases patients (369 breast cancer, 316 breast benign lesions). The influence of thyroid hormones on chemotherapeutic efficacy was evaluated by chemosensitization test, to compare chemotherapeutic efficacy between breast cancer cells with chemotherapeutics plus triiodothyronine (T3) and chemotherapeutics only. Results In breast cancer, NTIS prevalence at the initial diagnosis was higher and increased during chemotherapy, but declined before the next chemotherapeutic course. Thyroid hormones decreased signigicantly during chemotherapy. T3 can enhance the chemosensitivity of MCF-7 to 5-Fu and taxol, with progression from G0-G1 phase to S phase. The similar chemosensitization role of T3 were found in MDA-MB-231. We compared chemotherapeutic efficacy among groups with different usage modes of T3, finding pretreatment with lower dose of T3, using

Low work-function thermionic emission and orbital-motion-limited ion collection at bare-tether cathodic contact

Energy Technology Data Exchange (ETDEWEB)

Chen, Xin, E-mail: xin.chen@upm.es; Sanmartín, J. R., E-mail: juanr.sanmartin@upm.es [Departamento de Física Aplicada, Escuela Técnica Superior de Ingeniería Aeronáutica y del Espacio, Universidad Politécnica de Madrid, Plaza Cardenal Cisneros, 3, 28040 Madrid (Spain)

2015-05-15

With a thin coating of low-work-function material, thermionic emission in the cathodic segment of bare tethers might be much greater than orbital-motion-limited (OML) ion collection current. The space charge of the emitted electrons decreases the electric field that accelerates them outwards, and could even reverse it for high enough emission, producing a potential hollow. In this work, at the conditions of high bias and relatively low emission that make the potential monotonic, an asymptotic analysis is carried out, extending the OML ion-collection analysis to investigate the probe response due to electrons emitted by the negatively biased cylindrical probe. At given emission, the space charge effect from emitted electrons increases with decreasing magnitude of negative probe bias. Although emitted electrons present negligible space charge far away from the probe, their effect cannot be neglected in the global analysis for the sheath structure and two thin layers in between sheath and the quasineutral region. The space-charge-limited condition is located. It is found that thermionic emission increases the range of probe radius for OML validity and is greatly more effective than ion collection for cathodic contact of tethers.

The brain matures with stronger functional connectivity and decreased randomness of its network.

Directory of Open Access Journals (Sweden)

Dirk J A Smit

Full Text Available We investigated the development of the brain's functional connectivity throughout the life span (ages 5 through 71 years by measuring EEG activity in a large population-based sample. Connectivity was established with Synchronization Likelihood. Relative randomness of the connectivity patterns was established with Watts and Strogatz' (1998 graph parameters C (local clustering and L (global path length for alpha (~10 Hz, beta (~20 Hz, and theta (~4 Hz oscillation networks. From childhood to adolescence large increases in connectivity in alpha, theta and beta frequency bands were found that continued at a slower pace into adulthood (peaking at ~50 yrs. Connectivity changes were accompanied by increases in L and C reflecting decreases in network randomness or increased order (peak levels reached at ~18 yrs. Older age (55+ was associated with weakened connectivity. Semi-automatically segmented T1 weighted MRI images of 104 young adults revealed that connectivity was significantly correlated to cerebral white matter volume (alpha oscillations: r = 33, p<01; theta: r = 22, p<05, while path length was related to both white matter (alpha: max. r = 38, p<001 and gray matter (alpha: max. r = 36, p<001; theta: max. r = 36, p<001 volumes. In conclusion, EEG connectivity and graph theoretical network analysis may be used to trace structural and functional development of the brain.

Decreased Fibroblast and Increased Osteoblast Functions on Ionic Plasma Deposited Nanostructured Ti Coatings

Directory of Open Access Journals (Sweden)

Storey Dan

2007-01-01

Full Text Available AbstractBioactive coatings are in high demand to control cellular functions for numerous medical devices. The objective of this in vitro study was to characterize for the first time fibroblast (fibrous scar tissue forming cells adhesion and proliferation on an important polymeric biomaterial (silicone coated with titanium using a novel ionic plasma deposition (IPD process. Fibroblasts are one of the first anchorage-dependent cells to arrive at an implant surface during the wound healing process. Persistent excessive functions of fibroblasts have been linked to detrimental fibrous tissue formation which may cause implant failure. The IPD process creates a surface-engineered nanostructure (with features usually below 100 nm by first using a vacuum to remove all contaminants, then guiding charged metallic ions or plasma to the surface of a medical device at ambient temperature. Results demonstrated that compared to currently used titanium and uncoated silicone, silicone coated with titanium using IPD significantly decreased fibroblast adhesion and proliferation. Results also showed competitively increased osteoblast (bone-forming cells over fibroblast adhesion on silicone coated with titanium; in contrast, osteoblast adhesion was not competitively increased over fibroblast adhesion on uncoated silicone or titanium controls. In this manner, this study strongly suggests that IPD should be further studied for biomaterial applications in which fibrous tissue encapsulation is undesirable (such as for orthopedic implants, cardiovascular components, etc..

Monotonicity and concavity in Coulomb systems

International Nuclear Information System (INIS)

Englisch, R.; Englisch, H.; Karl-Marx-Universitaet, Leipzig

1986-01-01

The eigenvalues of H(α) = H 0 + αH * , where H * is an arbitrary Coulomb potential, decrease with increasing α ≥ 0. Linear and parabolic bounds for the ground state energy are presented. These bounds are applied to the biexciton and the exciton at a neutral donor. (orig.)

Dynamics of inequalities in geometric function theory

Directory of Open Access Journals (Sweden)

Reich Simeon

2001-01-01

Full Text Available A domain in the complex plane which is star-like with respect to a boundary point can be approximated by domains which are star-like with respect to interior points. This approximation process can be viewed dynamically as an evolution of the null points of the underlying holomorphic functions from the interior of the open unit disk towards a boundary point. We trace these dynamics analytically in terms of the Alexander–Nevanlinna and Robertson inequalities by using the framework of complex dynamical systems and hyperbolic monotonicity.

Decreased Respiratory Muscle Function Is Associated with Impaired Trunk Balance among Chronic Stroke Patients: A Cross-sectional Study.

Science.gov (United States)

Lee, Kyeongbong; Cho, Ji-Eun; Hwang, Dal-Yeon; Lee, WanHee

2018-06-01

The abdominal muscles play a role in trunk balance. Abdominal muscle thickness is asymmetrical in stroke survivors, who also have decreased respiratory muscle function. We compared the thickness of the abdominal muscles between the affected and less affected sides in stroke survivors. In addition, the relationship between respiratory muscle function and trunk balance was evaluated. Chronic stroke patients (18 men, 15 women; mean age, 58.94 ± 12.30 years; Mini-Mental Status Examination score ≥ 24) who could sit without assist were enrolled. Abdominal muscle thickness during rest and contraction was measured with ultrasonography, and the thickening ratio was calculated. Respiratory muscle function assessment included maximum respiratory pressure, peak flow, and air volume. Trunk function was evaluated using the Trunk Impairment Scale, and trunk balance was estimated based on the center of pressure velocity and path length within the limit of stability in sitting posture. Abdominal muscles were significantly thinner on the affected side, and the thickening ratio was lower in the affected side (P respiratory muscle function was significantly correlated with higher level of trunk function and balance in stroke patients (P respiratory muscle function has positive correlation with trunk function and balance. We propose that respiratory muscle training should be included as part of trunk balance training in chronic stroke patients.

Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action

Science.gov (United States)

Carvalho Poyraz, Fernanda; Holzner, Eva; Bailey, Matthew R.; Meszaros, Jozsef; Kenney, Lindsay; Kheirbek, Mazen A.

2016-01-01

Altered dopamine D2 receptor (D2R) binding in the striatum has been associated with abnormal motivation in neuropsychiatric disorders, including schizophrenia. Here, we tested whether motivational deficits observed in mice with upregulated D2Rs (D2R-OEdev mice) are reversed by decreasing function of the striatopallidal “no-go” pathway. To this end, we expressed the Gαi-coupled designer receptor hM4D in adult striatopallidal neurons and activated the receptor with clozapine-N-oxide (CNO). Using a head-mounted miniature microscope we confirmed with calcium imaging in awake mice that hM4D activation by CNO inhibits striatopallidal function measured as disinhibited downstream activity in the globus pallidus. Mice were then tested in three operant tasks that address motivated behavior, the progressive ratio task, the progressive hold-down task, and outcome devaluation. Decreasing striatopallidal function in the dorsomedial striatum or nucleus accumbens core enhanced motivation in D2R-OEdev mice and control littermates. This effect was due to increased response initiation but came at the cost of goal-directed efficiency. Moreover, response vigor and the sensitivity to changes in reward value were not altered. Chronic activation of hM4D by administering CNO for 2 weeks in drinking water did not affect motivation due to a tolerance effect. However, the acute effect of CNO on motivation was reinstated after discontinuing chronic treatment for 48 h. Used as a therapeutic approach, striatopallidal inhibition should consider the risk of impairing goal-directed efficiency and behavioral desensitization. SIGNIFICANCE STATEMENT Motivation involves a directional component that allows subjects to efficiently select the behavior that will lead to an optimal outcome and an activational component that initiates and maintains the vigor and persistence of actions. Striatal output pathways modulate motivated behavior, but it remains unknown how these pathways regulate specific

Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action.

Science.gov (United States)

Carvalho Poyraz, Fernanda; Holzner, Eva; Bailey, Matthew R; Meszaros, Jozsef; Kenney, Lindsay; Kheirbek, Mazen A; Balsam, Peter D; Kellendonk, Christoph

2016-06-01

Altered dopamine D2 receptor (D2R) binding in the striatum has been associated with abnormal motivation in neuropsychiatric disorders, including schizophrenia. Here, we tested whether motivational deficits observed in mice with upregulated D2Rs (D2R-OEdev mice) are reversed by decreasing function of the striatopallidal "no-go" pathway. To this end, we expressed the Gαi-coupled designer receptor hM4D in adult striatopallidal neurons and activated the receptor with clozapine-N-oxide (CNO). Using a head-mounted miniature microscope we confirmed with calcium imaging in awake mice that hM4D activation by CNO inhibits striatopallidal function measured as disinhibited downstream activity in the globus pallidus. Mice were then tested in three operant tasks that address motivated behavior, the progressive ratio task, the progressive hold-down task, and outcome devaluation. Decreasing striatopallidal function in the dorsomedial striatum or nucleus accumbens core enhanced motivation in D2R-OEdev mice and control littermates. This effect was due to increased response initiation but came at the cost of goal-directed efficiency. Moreover, response vigor and the sensitivity to changes in reward value were not altered. Chronic activation of hM4D by administering CNO for 2 weeks in drinking water did not affect motivation due to a tolerance effect. However, the acute effect of CNO on motivation was reinstated after discontinuing chronic treatment for 48 h. Used as a therapeutic approach, striatopallidal inhibition should consider the risk of impairing goal-directed efficiency and behavioral desensitization. Motivation involves a directional component that allows subjects to efficiently select the behavior that will lead to an optimal outcome and an activational component that initiates and maintains the vigor and persistence of actions. Striatal output pathways modulate motivated behavior, but it remains unknown how these pathways regulate specific components of motivation. Here

Time-dependent density functional theory for the charging kinetics of electric double layer containing room-temperature ionic liquids.

Science.gov (United States)

Lian, Cheng; Zhao, Shuangliang; Liu, Honglai; Wu, Jianzhong

2016-11-28

Understanding the charging kinetics of electric double layers is of fundamental importance for the design and development of novel electrochemical devices such as supercapacitors and field-effect transistors. In this work, we study the dynamic behavior of room-temperature ionic liquids using a classical time-dependent density functional theory that accounts for the molecular excluded volume effects, the electrostatic correlations, and the dispersion forces. While the conventional models predict a monotonic increase of the surface charge with time upon application of an electrode voltage, our results show that dispersion between ions results in a non-monotonic increase of the surface charge with the duration of charging. Furthermore, we investigate the effects of van der Waals attraction between electrode/ionic-liquid interactions on the charging processes.

Mathematical Modeling of Contact Resistance in Silicon Photovoltaic Cells

KAUST Repository

Black, J. P.

2013-10-22

In screen-printed silicon-crystalline solar cells, the contact resistance of a thin interfacial glass layer between the silicon and the silver electrode plays a limiting role for electron transport. We analyze a simple model for electron transport across this layer, based on the driftdiffusion equations. We utilize the size of the current/Debye length to conduct asymptotic techniques to simplify the model; we solve the model numerically to find that the effective contact resistance may be a monotonic increasing, monotonic decreasing, or nonmonotonic function of the electron flux, depending on the values of the physical parameters. © 2013 Society for Industrial and Applied Mathematics.

Ketamine decreases resting state functional network connectivity in healthy subjects: implications for antidepressant drug action.

Directory of Open Access Journals (Sweden)

Milan Scheidegger

Full Text Available Increasing preclinical and clinical evidence underscores the strong and rapid antidepressant properties of the glutamate-modulating NMDA receptor antagonist ketamine. Targeting the glutamatergic system might thus provide a novel molecular strategy for antidepressant treatment. Since glutamate is the most abundant and major excitatory neurotransmitter in the brain, pathophysiological changes in glutamatergic signaling are likely to affect neurobehavioral plasticity, information processing and large-scale changes in functional brain connectivity underlying certain symptoms of major depressive disorder. Using resting state functional magnetic resonance imaging (rsfMRI, the "dorsal nexus "(DN was recently identified as a bilateral dorsal medial prefrontal cortex region showing dramatically increased depression-associated functional connectivity with large portions of a cognitive control network (CCN, the default mode network (DMN, and a rostral affective network (AN. Hence, Sheline and colleagues (2010 proposed that reducing increased connectivity of the DN might play a critical role in reducing depression symptomatology and thus represent a potential therapy target for affective disorders. Here, using a randomized, placebo-controlled, double-blind, crossover rsfMRI challenge in healthy subjects we demonstrate that ketamine decreases functional connectivity of the DMN to the DN and to the pregenual anterior cingulate (PACC and medioprefrontal cortex (MPFC via its representative hub, the posterior cingulate cortex (PCC. These findings in healthy subjects may serve as a model to elucidate potential biomechanisms that are addressed by successful treatment of major depression. This notion is further supported by the temporal overlap of our observation of subacute functional network modulation after 24 hours with the peak of efficacy following an intravenous ketamine administration in treatment-resistant depression.

Nonlinear generalized synchronization of chaotic systems by pure error dynamics and elaborate nondiagonal Lyapunov function

International Nuclear Information System (INIS)

Ge Zhengming; Chang Chingming

2009-01-01

By applying pure error dynamics and elaborate nondiagonal Lyapunov function, the nonlinear generalized synchronization is studied in this paper. Instead of current mixed error dynamics in which master state variables and slave state variables are presented, the nonlinear generalized synchronization can be obtained by pure error dynamics without auxiliary numerical simulation. The elaborate nondiagonal Lyapunov function is applied rather than current monotonous square sum Lyapunov function deeply weakening the powerfulness of Lyapunov direct method. Both autonomous and nonautonomous double Mathieu systems are used as examples with numerical simulations.

Dhage Iteration Method for Generalized Quadratic Functional Integral Equations

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Bapurao C. Dhage

2015-01-01

Full Text Available In this paper we prove the existence as well as approximations of the solutions for a certain nonlinear generalized quadratic functional integral equation. An algorithm for the solutions is developed and it is shown that the sequence of successive approximations starting at a lower or upper solution converges monotonically to the solutions of related quadratic functional integral equation under some suitable mixed hybrid conditions. We rely our main result on Dhage iteration method embodied in a recent hybrid fixed point theorem of Dhage (2014 in partially ordered normed linear spaces. An example is also provided to illustrate the abstract theory developed in the paper.

Decreasing Relative Risk Premium

DEFF Research Database (Denmark)

Hansen, Frank

relative risk premium in the small implies decreasing relative risk premium in the large, and decreasing relative risk premium everywhere implies risk aversion. We finally show that preferences with decreasing relative risk premium may be equivalently expressed in terms of certain preferences on risky......We consider the risk premium demanded by a decision maker with wealth x in order to be indifferent between obtaining a new level of wealth y1 with certainty, or to participate in a lottery which either results in unchanged present wealth or a level of wealth y2 > y1. We define the relative risk...... premium as the quotient between the risk premium and the increase in wealth y1–x which the decision maker puts on the line by choosing the lottery in place of receiving y1 with certainty. We study preferences such that the relative risk premium is a decreasing function of present wealth, and we determine...

Inelastic behavior of cold-formed braced walls under monotonic and cyclic loading

Science.gov (United States)

Gerami, Mohsen; Lotfi, Mohsen; Nejat, Roya

2015-06-01

The ever-increasing need for housing generated the search for new and innovative building methods to increase speed and efficiency and enhance quality. One method is the use of light thin steel profiles as load-bearing elements having different solutions for interior and exterior cladding. Due to the increase in CFS construction in low-rise residential structures in the modern construction industry, there is an increased demand for performance inelastic analysis of CFS walls. In this study, the nonlinear behavior of cold-formed steel frames with various bracing arrangements including cross, chevron and k-shape straps was evaluated under cyclic and monotonic loading and using nonlinear finite element analysis methods. In total, 68 frames with different bracing arrangements and different ratios of dimensions were studied. Also, seismic parameters including resistance reduction factor, ductility and force reduction factor due to ductility were evaluated for all samples. On the other hand, the seismic response modification factor was calculated for these systems. It was concluded that the highest response modification factor would be obtained for walls with bilateral cross bracing systems with a value of 3.14. In all samples, on increasing the distance of straps from each other, shear strength increased and shear strength of the wall with bilateral bracing system was 60 % greater than that with lateral bracing system.

Cognitive-behavioral therapy for children with functional abdominal pain and their parents decreases pain and other symptoms.

Science.gov (United States)

Levy, Rona L; Langer, Shelby L; Walker, Lynn S; Romano, Joan M; Christie, Dennis L; Youssef, Nader; DuPen, Melissa M; Feld, Andrew D; Ballard, Sheri A; Welsh, Ericka M; Jeffery, Robert W; Young, Melissa; Coffey, Melissa J; Whitehead, William E

2010-04-01

Unexplained abdominal pain in children has been shown to be related to parental responses to symptoms. This randomized controlled trial tested the efficacy of an intervention designed to improve outcomes in idiopathic childhood abdominal pain by altering parental responses to pain and children's ways of coping and thinking about their symptoms. Two hundred children with persistent functional abdominal pain and their parents were randomly assigned to one of two conditions-a three-session intervention of cognitive-behavioral treatment targeting parents' responses to their children's pain complaints and children's coping responses, or a three-session educational intervention that controlled for time and attention. Parents and children were assessed at pretreatment, and 1 week, 3 months, and 6 months post-treatment. Outcome measures were child and parent reports of child pain levels, function, and adjustment. Process measures included parental protective responses to children's symptom reports and child coping methods. Children in the cognitive-behavioral condition showed greater baseline to follow-up decreases in pain and gastrointestinal symptom severity (as reported by parents) than children in the comparison condition (time x treatment interaction, Pparents in the cognitive-behavioral condition reported greater decreases in solicitous responses to their child's symptoms compared with parents in the comparison condition (time x treatment interaction, Pparental responses and increasing child coping skills is effective in reducing children's pain and symptom levels compared with an educational control condition.

Neurogenic detrusor overactivity is associated with decreased expression and function of the large conductance voltage- and Ca(2+-activated K(+ channels.

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Kiril L Hristov

Full Text Available Patients suffering from a variety of neurological diseases such as spinal cord injury, Parkinson's disease, and multiple sclerosis often develop neurogenic detrusor overactivity (NDO, which currently lacks a universally effective therapy. Here, we tested the hypothesis that NDO is associated with changes in detrusor smooth muscle (DSM large conductance Ca(2+-activated K(+ (BK channel expression and function. DSM tissue samples from 33 patients were obtained during open bladder surgeries. NDO patients were clinically characterized preoperatively with pressure-flow urodynamics demonstrating detrusor overactivity, in the setting of a clinically relevant neurological condition. Control patients did not have overactive bladder and did not have a clinically relevant neurological disease. We conducted quantitative polymerase chain reactions (qPCR, perforated patch-clamp electrophysiology on freshly-isolated DSM cells, and functional studies on DSM contractility. qPCR experiments revealed that DSM samples from NDO patients showed decreased BK channel mRNA expression in comparison to controls. Patch-clamp experiments demonstrated reduced whole cell and transient BK currents (TBKCs in freshly-isolated DSM cells from NDO patients. Functional studies on DSM contractility showed that spontaneous phasic contractions had a decreased sensitivity to iberiotoxin, a selective BK channel inhibitor, in DSM strips isolated from NDO patients. These results reveal the novel finding that NDO is associated with decreased DSM BK channel expression and function leading to increased DSM excitability and contractility. BK channel openers or BK channel gene transfer could be an alternative strategy to control NDO. Future clinical trials are needed to evaluate the value of BK channel opening drugs or gene therapies for NDO treatment and to identify any possible adverse effects.

Bird functional diversity decreases with time since disturbance: Does patchy prescribed fire enhance ecosystem function?.

Science.gov (United States)

Sitters, Holly; Di Stefano, Julian; Christie, Fiona; Swan, Matthew; York, Alan

2016-01-01

Animal species diversity is often associated with time since disturbance, but the effects of disturbances such as fire on functional diversity are unknown. Functional diversity measures the range, abundance, and distribution of trait values in a community, and links changes in species composition with the consequences for ecosystem function. Improved understanding of the relationship between time since fire (TSF) and functional diversity is critical given that the frequency of both prescribed fire and wildfire is expected to increase. To address this knowledge gap, we examined responses of avian functional diversity to TSF and two direct measures of environmental heterogeneity, plant diversity, and structural heterogeneity. We surveyed birds across a 70-year chronosequence spanning four vegetation types in southeast Australia. Six bird functional traits were used to derive four functional diversity indices (richness, evenness, divergence, and dispersion) and the effects of TSF, plant diversity and structural heterogeneity on species richness and the functional diversity indices were examined using mixed models. We used a regression tree method to identify traits associated with species more common in young vegetation. Functional richness and dispersion were negatively associated with TSF in all vegetation types, suggesting that recent prescribed fire generates heterogeneous vegetation and provides greater opportunities for resource partitioning. Species richness was not significantly associated with TSF, and is probably an unreliable surrogate for functional diversity in fire-prone systems. A positive, relationship between functional evenness and structural heterogeneity was comnon to all vegetation types, suggesting that fine-scale (tens of meters) structural variation can enhance ecosystem function. Species more common in young vegetation were primarily linked by their specialist diets, indicating that ecosystem services such as seed dispersal and insect control

Isolating spectral cues in amplitude and quasi-frequency modulation discrimination by reducing stimulus duration.

Science.gov (United States)

Borucki, Ewa; Berg, Bruce G

2017-05-01

This study investigated the psychophysical effects of distortion products in a listening task traditionally used to estimate the bandwidth of phase sensitivity. For a 2000 Hz carrier, estimates of modulation depth necessary to discriminate amplitude modulated (AM) tones and quasi-frequency modulated (QFM) were measured in a two interval forced choice task as a function modulation frequency. Temporal modulation transfer functions were often non-monotonic at modulation frequencies above 300 Hz. This was likely to be due to a spectral cue arising from the interaction of auditory distortion products and the lower sideband of the stimulus complex. When the stimulus duration was decreased from 200 ms to 20 ms, thresholds for low-frequency modulators rose to near-chance levels, whereas thresholds in the region of non-monotonicities were less affected. The decrease in stimulus duration appears to hinder the listener's ability to use temporal cues in order to discriminate between AM and QFM, whereas spectral information derived from distortion product cues appears more resilient. Copyright © 2017. Published by Elsevier B.V.

Self-care essential extras: an integration of holistic nursing, functional medicine, and health coaching to promote therapeutic lifestyle change and decrease chronic disease.

Science.gov (United States)

Scattergood, Donna M

2010-01-01

The Essential Vitality Program blends holistic nursing, functional medicine, and health coaching to promote lifestyle changes that modify risk factors of costly chronic disease. Karl is a client who experienced enhanced vitality, decreased chronic pain and medications use, and improved meaningful functioning, by partnering with a holistic nurse coach.

Response of skirted suction caissons to monotonic lateral loading in saturated medium sand

Science.gov (United States)

Li, Da-yong; Zhang, Yu-kun; Feng, Ling-yun; Guo, Yan-xue

2014-08-01

Monotonic lateral load model tests were carried out on steel skirted suction caissons embedded in the saturated medium sand to study the bearing capacity. A three-dimensional continuum finite element model was developed with Z_SOIL software. The numerical model was calibrated against experimental results. Soil deformation and earth pressures on skirted caissons were investigated by using the finite element model to extend the model tests. It shows that the "skirted" structure can significantly increase the lateral capacity and limit the deflection, especially suitable for offshore wind turbines, compared with regular suction caissons without the "skirted" at the same load level. In addition, appropriate determination of rotation centers plays a crucial role in calculating the lateral capacity by using the analytical method. It was also found that the rotation center is related to dimensions of skirted suction caissons and loading process, i.e. the rotation center moves upwards with the increase of the "skirted" width and length; moreover, the rotation center moves downwards with the increase of loading and keeps constant when all the sand along the caisson's wall yields. It is so complex that we cannot simply determine its position like the regular suction caisson commonly with a specified position to the length ratio of the caisson.

Non-monotonic compositional dependence of isothermal bulk modulus of the (Mg1–xMnxCr2O4 spinel solid solutions, and its origin and implication

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Xi Liu

2016-12-01

Full Text Available The compressibility of the spinel solid solutions, (Mg1−xMnxCr2O4 with x = 0.00 (0, 0.20 (0, 0.44 (2, 0.61 (2, 0.77 (2 and 1.00 (0, has been investigated by using a diamond-anvil cell coupled with synchrotron X-ray radiation up to ∼10 GPa (ambient T. The second-order Birch–Murnaghan equation of state was used to fit the PV data, yielding the following values for the isothermal bulk moduli (KT, 198.2 (36, 187.8 (87, 176.1 (32, 168.7 (52, 192.9 (61 and 199.2 (61 GPa, for the spinel solid solutions with x = 0.00 (0, 0.20 (0, 0.44 (2, 0.61 (2, 0.77 (2 and 1.00 (0, respectively (KT′ fixed as 4. The KT value of the MgCr2O4 spinel is in good agreement with existing experimental determinations and theoretical calculations. The correlation between the KT and x is not monotonic, with the KT values similar at both ends of the binary MgCr2O4MnCr2O4, but decreasing towards the middle. This non-monotonic correlation can be described by two equations, KT = −49.2 (11x + 198.0 (4 (x ≤ ∼0.6 and KT = 92 (41x + 115 (30 (x ≥ ∼0.6, and can be explained by the evolution of the average bond lengths of the tetrahedra and octahedra of the spinel solid solutions. Additionally, the relationship between the thermal expansion coefficient and composition is correspondingly reinterpreted, the continuous deformation of the oxygen array is demonstrated, and the evolution of the component polyhedra is discussed for this series of spinel solid solutions. Our results suggest that the correlation between the KT and composition of a solid solution series may be complicated, and great care should be paid while estimating the KT of some intermediate compositions from the KT of the end-members.

Monotonicity of the dynamical activity

Czech Academy of Sciences Publication Activity Database

Maes, C.; Netočný, Karel; Wynants, B.

2012-01-01

Roč. 45, č. 45 (2012), 1-13 ISSN 1751-8113 Institutional research plan: CEZ:AV0Z10100520 Keywords : nonequilibrium steady state * Lyapunov function * dynamical activity Subject RIV: BE - Theoretical Physics Impact factor: 1.766, year: 2012 http://iopscience.iop.org/1751-8121/45/45/455001/

Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential

Science.gov (United States)

Attene-Ramos, Matias S.; Huang, Ruili; Michael, Sam; Witt, Kristine L.; Richard, Ann; Tice, Raymond R.; Simeonov, Anton; Austin, Christopher P.

2014-01-01

Background: Mitochondrial dysfunction has been implicated in the pathogenesis of a variety of disorders including cancer, diabetes, and neurodegenerative and cardiovascular diseases. Understanding whether different environmental chemicals and druglike molecules impact mitochondrial function represents an initial step in predicting exposure-related toxicity and defining a possible role for such compounds in the onset of various diseases. Objectives: We sought to identify individual chemicals and general structural features associated with changes in mitochondrial membrane potential (MMP). Methods: We used a multiplexed [two end points in one screen; MMP and adenosine triphosphate (ATP) content] quantitative high throughput screening (qHTS) approach combined with informatics tools to screen the Tox21 library of 10,000 compounds (~ 8,300 unique chemicals) at 15 concentrations each in triplicate to identify chemicals and structural features that are associated with changes in MMP in HepG2 cells. Results: Approximately 11% of the compounds (913 unique compounds) decreased MMP after 1 hr of treatment without affecting cell viability (ATP content). In addition, 309 compounds decreased MMP over a concentration range that also produced measurable cytotoxicity [half maximal inhibitory concentration (IC50) in MMP assay/IC50 in viability assay ≤ 3; p Tice RR, Simeonov A, Austin CP, Xia M. 2015. Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. Environ Health Perspect 123:49–56; http://dx.doi.org/10.1289/ehp.1408642 PMID:25302578

Monotonic and cyclic bond behavior of confined concrete using NiTiNb SMA wires

International Nuclear Information System (INIS)

Choi, Eunsoo; Chung, Young-Soo; Kim, Yeon-Wook; Kim, Joo-Woo

2011-01-01

This study conducts bond tests of reinforced concrete confined by shape memory alloy (SMA) wires which provide active and passive confinement of concrete. This study uses NiTiNb SMA which usually shows wide temperature hysteresis; this is a good advantage for the application of shape memory effects. The aims of this study are to investigate the behavior of SMA wire under residual stress and the performance of SMA wire jackets in improving bond behavior through monotonic-loading tests. This study also conducts cyclic bond tests and analyzes cyclic bond behavior. The use of SMA wire jackets transfers the bond failure from splitting to pull-out mode and satisfactorily increases bond strength and ductile behavior. The active confinement provided by the SMA plays a major role in providing external pressure on the concrete because the developed passive confinement is much smaller than the active confinement. For cyclic behavior, slip and circumferential strain are recovered more with larger bond stress. This recovery of slip and circumferential strain are mainly due to the external pressure of the SMA wires since cracked concrete cannot provide any elastic recovery

Pade approximants for entire functions with regularly decreasing Taylor coefficients

International Nuclear Information System (INIS)

Rusak, V N; Starovoitov, A P

2002-01-01

For a class of entire functions the asymptotic behaviour of the Hadamard determinants D n,m as 0≤m≤m(n)→∞ and n→∞ is described. This enables one to study the behaviour of parabolic sequences from Pade and Chebyshev tables for many individual entire functions. The central result of the paper is as follows: for some sequences {(n,m(n))} in certain classes of entire functions (with regular Taylor coefficients) the Pade approximants {π n,m(n) }, which provide the locally best possible rational approximations, converge to the given function uniformly on the compact set D={z:|z|≤1} with asymptotically best rate

A new analysing approach for the structure of density fluctuation of supercritical fluid

International Nuclear Information System (INIS)

Sato, T; Sugiyama, M; Itoh, K; Mori, K; Fukunaga, T; Misawa, M; Otomo, T; Takata, S

2008-01-01

Large scale structural evolution of supercritical carbon dioxide along the isotherm at 32 deg. C was investigated with small-angle neutron scattering. The maximum of the density fluctuation, the so-called 'ridge', was confirmed with Ornstein-Zernike analysis. To investigate the structural change in more detail, the molecular distribution over a large domain was determined with a newly developed reverse Monte Carlo method. From the molecular distribution obtained, the pair distribution function and cluster-size distribution can be calculated. With increasing density of carbon dioxide, the cluster size increases monotonically, whereas the pair distribution function for the range of sizes shorter than 10 A shows a monotonic decrease. From this result, it is suggested that the structural change along the isotherm is caused by the change of balance between growth of clusters and increase of the average density

Current Smoking Dose-Dependently Associated with Decreased β-Cell Function in Chinese Men without Diabetes

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Chun Wang

2015-01-01

Full Text Available The aim of this study was to evaluate the associations between chronic smoking and insulin resistance and β-cell function in Chinese men without diabetes. A total of 1,568 participants were recruited by multistage sampling. Using homeostatic model assessment (HOMA, geometric means of insulin resistance (HOMA-IR and β-cell function (HOMA-β with 95% confidence interval (CI were calculated by general linear model. Odds ratios (ORs with 95% CI were estimated to evaluate the associations between smoking status and insulin resistance and β-cell deficiency under a logistic regression model. Current smokers had higher levels of 2 h glucose (6.66 versus 6.48 mmol/L for oral glucose tolerance test and lower levels of fasting insulin (5.68 versus 6.03 mU/L than never smokers. The adjusted means for HOMA-β (% were 54.86 in current smokers and 58.81 in never smokers (P=0.0257. Current smoking was associated with β-cell deficiency (OR 1.29, 95% CI 1.01–1.64 compared to never smoking. The β-cell function gradually decreased with increasing smoking intensity (Ptrend=0.0026, and the differences were statistically significant when the pack-year of smoking was 20 or above. No association was observed between smoking status and HOMA-IR. Our study suggested that chronic smoking may dose-dependently suppress insulin secretion in Chinese men.

A Complexity Analysis of Functional Interpretations

DEFF Research Database (Denmark)

Hernest, Mircea-Dan; Kohlenbach, Ulrich

2003-01-01

We give a quantitative analysis of G ̈odel’s functional interpretation and its monotone variant. The two have been used for the extraction of programs and numerical bounds as well as for conservation results. They apply both to (semi-)intuitionistic as well as (combined with negative translation...... of the verifying proof. In all cases terms of size linear in the size of the proof at input can be extracted and the corresponding extraction algorithms have cubic worst-time complexity. The verifying proofs have depth linear in the depth of the proof at input and the maximal size of a formula of this proof....

Effect of structural relaxation of metallic glasses on positron annihilation parameters

International Nuclear Information System (INIS)

Tian Decheng; Xiong Liangyue; Tang Zhongxun; Xu Yinhua

1987-07-01

The results of a comparative study of positron lifetime and a Doppler broadening line-shape parameter for two metallic glasses are presented. The change of lifetime τ-bar and the S-parameter for these two metallic glasses are shown to have a common feature, i.e. at the initial stage of structural relaxation, τ-bar presents a peak-form as a function of annealing time or temperature while the S-parameter decreases monotonically. A possible mechanism is proposed for explaining the peak-form of τ-bar which has been observed in many metallic glasses; the initial rise and the following decrease of τ-bar are attributed to the homogenization of defects taking place during the structural relaxation. The monotonic behaviour of the S-parameter seems to indicate that the annihilation of positrons in free state with the high momentum core electrons is negligible. (author). 8 refs, 2 figs

Search for scalar-tensor gravity theories with a non-monotonic time evolution of the speed-up factor

Energy Technology Data Exchange (ETDEWEB)

Navarro, A [Dept Fisica, Universidad de Murcia, E30071-Murcia (Spain); Serna, A [Dept Fisica, Computacion y Comunicaciones, Universidad Miguel Hernandez, E03202-Elche (Spain); Alimi, J-M [Lab. de l' Univers et de ses Theories (LUTH, CNRS FRE2462), Observatoire de Paris-Meudon, F92195-Meudon (France)

2002-08-21

We present a method to detect, in the framework of scalar-tensor gravity theories, the existence of stationary points in the time evolution of the speed-up factor. An attractive aspect of this method is that, once the particular scalar-tensor theory has been specified, the stationary points are found through a simple algebraic equation which does not contain any integration. By applying this method to the three classes of scalar-tensor theories defined by Barrow and Parsons, we have found several new cosmological models with a non-monotonic evolution of the speed-up factor. The physical interest of these models is that, as previously shown by Serna and Alimi, they predict the observed primordial abundance of light elements for a very wide range of baryon density. These models are then consistent with recent CMB and Lyman-{alpha} estimates of the baryon content of the universe.

Topological characteristics of multi-valued maps and Lipschitzian functionals

International Nuclear Information System (INIS)

Klimov, V S

2008-01-01

This paper deals with the operator inclusion O element of F(x)+N Q (x), where F is a multi-valued map of monotonic type from a reflexive space V to its conjugate V * and N Q is the cone normal to the closed set Q, which, generally speaking, is not convex. To estimate the number of solutions of this inclusion we introduce topological characteristics of multi-valued maps and Lipschitzian functionals that have the properties of additivity and homotopy invariance. We prove some infinite-dimensional versions of the Poincare-Hopf theorem

Quorum-Sensing Synchronization of Synthetic Toggle Switches: A Design Based on Monotone Dynamical Systems Theory.

Directory of Open Access Journals (Sweden)

Evgeni V Nikolaev

2016-04-01

Full Text Available Synthetic constructs in biotechnology, biocomputing, and modern gene therapy interventions are often based on plasmids or transfected circuits which implement some form of "on-off" switch. For example, the expression of a protein used for therapeutic purposes might be triggered by the recognition of a specific combination of inducers (e.g., antigens, and memory of this event should be maintained across a cell population until a specific stimulus commands a coordinated shut-off. The robustness of such a design is hampered by molecular ("intrinsic" or environmental ("extrinsic" noise, which may lead to spontaneous changes of state in a subset of the population and is reflected in the bimodality of protein expression, as measured for example using flow cytometry. In this context, a "majority-vote" correction circuit, which brings deviant cells back into the required state, is highly desirable, and quorum-sensing has been suggested as a way for cells to broadcast their states to the population as a whole so as to facilitate consensus. In this paper, we propose what we believe is the first such a design that has mathematically guaranteed properties of stability and auto-correction under certain conditions. Our approach is guided by concepts and theory from the field of "monotone" dynamical systems developed by M. Hirsch, H. Smith, and others. We benchmark our design by comparing it to an existing design which has been the subject of experimental and theoretical studies, illustrating its superiority in stability and self-correction of synchronization errors. Our stability analysis, based on dynamical systems theory, guarantees global convergence to steady states, ruling out unpredictable ("chaotic" behaviors and even sustained oscillations in the limit of convergence. These results are valid no matter what are the values of parameters, and are based only on the wiring diagram. The theory is complemented by extensive computational bifurcation analysis

GroEL1, a heat shock protein 60 of Chlamydia pneumoniae, impairs neovascularization by decreasing endothelial progenitor cell function.

Directory of Open Access Journals (Sweden)

Yi-Wen Lin

Full Text Available The number and function of endothelial progenitor cells (EPCs are sensitive to hyperglycemia, hypertension, and smoking in humans, which are also associated with the development of atherosclerosis. GroEL1 from Chlamydia pneumoniae has been found in atherosclerotic lesions and is related to atherosclerotic pathogenesis. However, the actual effects of GroEL1 on EPC function are unclear. In this study, we investigate the EPC function in GroEL1-administered hind limb-ischemic C57BL/B6 and C57BL/10ScNJ (a toll-like receptor 4 (TLR4 mutation mice and human EPCs. In mice, laser Doppler imaging, flow cytometry, and immunohistochemistry were used to evaluate the degree of neo-vasculogenesis, circulating level of EPCs, and expression of CD34, vWF, and endothelial nitric oxide synthase (eNOS in vessels. Blood flow in the ischemic limb was significantly impaired in C57BL/B6 but not C57BL/10ScNJ mice treated with GroEL1. Circulating EPCs were also decreased after GroEL1 administration in C57BL/B6 mice. Additionally, GroEL1 inhibited the expression of CD34 and eNOS in C57BL/B6 ischemic muscle. In vitro, GroEL1 impaired the capacity of differentiation, mobilization, tube formation, and migration of EPCs. GroEL1 increased senescence, which was mediated by caspases, p38 MAPK, and ERK1/2 signaling in EPCs. Furthermore, GroEL1 decreased integrin and E-selectin expression and induced inflammatory responses in EPCs. In conclusion, these findings suggest that TLR4 and impaired NO-related mechanisms could contribute to the reduced number and functional activity of EPCs in the presence of GroEL1 from C. pneumoniae.

Decreased Cerebellar-Orbitofrontal Connectivity Correlates with Stuttering Severity: Whole-Brain Functional and Structural Connectivity Associations with Persistent Developmental Stuttering.

Science.gov (United States)

Sitek, Kevin R; Cai, Shanqing; Beal, Deryk S; Perkell, Joseph S; Guenther, Frank H; Ghosh, Satrajit S

2016-01-01

Persistent developmental stuttering is characterized by speech production disfluency and affects 1% of adults. The degree of impairment varies widely across individuals and the neural mechanisms underlying the disorder and this variability remain poorly understood. Here we elucidate compensatory mechanisms related to this variability in impairment using whole-brain functional and white matter connectivity analyses in persistent developmental stuttering. We found that people who stutter had stronger functional connectivity between cerebellum and thalamus than people with fluent speech, while stutterers with the least severe symptoms had greater functional connectivity between left cerebellum and left orbitofrontal cortex (OFC). Additionally, people who stutter had decreased functional and white matter connectivity among the perisylvian auditory, motor, and speech planning regions compared to typical speakers, but greater functional connectivity between the right basal ganglia and bilateral temporal auditory regions. Structurally, disfluency ratings were negatively correlated with white matter connections to left perisylvian regions and to the brain stem. Overall, we found increased connectivity among subcortical and reward network structures in people who stutter compared to controls. These connections were negatively correlated with stuttering severity, suggesting the involvement of cerebellum and OFC may underlie successful compensatory mechanisms by more fluent stutterers.

Decreased Cerebellar-Orbitofrontal Connectivity Correlates with Stuttering Severity: Whole-Brain Functional and Structural Connectivity Associations with Persistent Developmental Stuttering

Science.gov (United States)

Sitek, Kevin R.; Cai, Shanqing; Beal, Deryk S.; Perkell, Joseph S.; Guenther, Frank H.; Ghosh, Satrajit S.

2016-01-01

Persistent developmental stuttering is characterized by speech production disfluency and affects 1% of adults. The degree of impairment varies widely across individuals and the neural mechanisms underlying the disorder and this variability remain poorly understood. Here we elucidate compensatory mechanisms related to this variability in impairment using whole-brain functional and white matter connectivity analyses in persistent developmental stuttering. We found that people who stutter had stronger functional connectivity between cerebellum and thalamus than people with fluent speech, while stutterers with the least severe symptoms had greater functional connectivity between left cerebellum and left orbitofrontal cortex (OFC). Additionally, people who stutter had decreased functional and white matter connectivity among the perisylvian auditory, motor, and speech planning regions compared to typical speakers, but greater functional connectivity between the right basal ganglia and bilateral temporal auditory regions. Structurally, disfluency ratings were negatively correlated with white matter connections to left perisylvian regions and to the brain stem. Overall, we found increased connectivity among subcortical and reward network structures in people who stutter compared to controls. These connections were negatively correlated with stuttering severity, suggesting the involvement of cerebellum and OFC may underlie successful compensatory mechanisms by more fluent stutterers. PMID:27199712

Decreased cerebellar-orbitofrontal connectivity correlates with stuttering severity: Whole-brain functional and structural connectivity associations with persistent developmental stuttering

Directory of Open Access Journals (Sweden)

Kevin Richard Sitek

2016-05-01

Full Text Available Persistent developmental stuttering is characterized by speech production disfluency and affects 1% of adults. The degree of impairment varies widely across individuals and the neural mechanisms underlying the disorder and this variability remain poorly understood. Here, we elucidate compensatory mechanisms related to this variability in impairment using whole-brain functional and white matter connectivity analyses in persistent developmental stuttering. We found that people who stutter had stronger functional connectivity between cerebellum and thalamus than people with fluent speech, while stutterers with the least severe symptoms had greater functional connectivity between left cerebellum and left orbitofrontal cortex. Additionally, people who stutter had decreased functional and white matter connectivity among the perisylvian auditory, motor, and speech planning regions compared to typical speakers, but greater functional connectivity between the right basal ganglia and bilateral temporal auditory regions. Structurally, disfluency ratings were negatively correlated with white matter connections to left perisylvian regions and to the brain stem. Overall, we found increased connectivity among subcortical and reward network structures in people who stutter compared to controls. These connections were negatively correlated with stuttering severity, suggesting the involvement of cerebellum and orbitofrontal cortex may underlie successful compensatory mechanisms by more fluent stutterers.

Decreased functional connectivity and structural deficit in alertness network with right-sided temporal lobe epilepsy.

Science.gov (United States)

Gao, Yujun; Zheng, Jinou; Li, Yaping; Guo, Danni; Wang, Mingli; Cui, Xiangxiang; Ye, Wei

2018-04-01

Patients with temporal lobe epilepsy (TLE) often suffer from alertness alterations. However, specific regions connected with alertness remain controversial, and whether these regions have structural impairment is also elusive. This study aimed to investigate the characteristics and neural mechanisms underlying the functions and structures of alertness network in patients with right-sided temporal lobe epilepsy (rTLE) by performing the attentional network test (ANT), resting-state functional magnetic resonance imaging (R-SfMRI), and diffusion tensor imaging (DTI).A total of 47 patients with rTLE and 34 healthy controls underwent ANT, R-SfMRI, and DTI scan. The seed-based functional connectivity (FC) method and deterministic tractography were used to analyze the data.Patients with rTLE had longer reaction times in the no-cue and double-cue conditions. However, no differences were noted in the alertness effect between the 2 groups. The patient group had lower FC compared with the control group in the right inferior parietal lobe (IPL), amygdala, and insula. Structural deficits were found in the right parahippocampal gyrus, superior temporal pole, insula, and amygdala in the patient group compared with the control group. Also significantly negative correlations were observed between abnormal fractional anisotropy (between the right insula and the superior temporal pole) and illness duration in the patients with rTLE.The findings of this study suggested abnormal intrinsic and phasic alertness, decreased FC, and structural deficits within the alerting network in the rTLE. This study provided new insights into the mechanisms of alertness alterations in rTLE.

Stationary distributions of stochastic processes described by a linear neutral delay differential equation

International Nuclear Information System (INIS)

Frank, T D

2005-01-01

Stationary distributions of processes are derived that involve a time delay and are defined by a linear stochastic neutral delay differential equation. The distributions are Gaussian distributions. The variances of the Gaussian distributions are either monotonically increasing or decreasing functions of the time delays. The variances become infinite when fixed points of corresponding deterministic processes become unstable. (letter to the editor)

Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function.

Directory of Open Access Journals (Sweden)

Cheryl Hemingway

Full Text Available The WHO estimates around a million children contract tuberculosis (TB annually with over 80 000 deaths from dissemination of infection outside of the lungs. The insidious onset and association with skin test anergy suggests failure of the immune system to both recognise and respond to infection. To understand the immune mechanisms, we studied genome-wide whole blood RNA expression in children with TB meningitis (TBM. Findings were validated in a second cohort of children with TBM and pulmonary TB (PTB, and functional T-cell responses studied in a third cohort of children with TBM, other extrapulmonary TB (EPTB and PTB. The predominant RNA transcriptional response in children with TBM was decreased abundance of multiple genes, with 140/204 (68% of all differentially regulated genes showing reduced abundance compared to healthy controls. Findings were validated in a second cohort with concordance of the direction of differential expression in both TBM (r2 = 0.78 p = 2x10-16 and PTB patients (r2 = 0.71 p = 2x10-16 when compared to a second group of healthy controls. Although the direction of expression of these significant genes was similar in the PTB patients, the magnitude of differential transcript abundance was less in PTB than in TBM. The majority of genes were involved in activation of leucocytes (p = 2.67E-11 and T-cell receptor signalling (p = 6.56E-07. Less abundant gene expression in immune cells was associated with a functional defect in T-cell proliferation that recovered after full TB treatment (p<0.0003. Multiple genes involved in T-cell activation show decreased abundance in children with acute TB, who also have impaired functional T-cell responses. Our data suggest that childhood TB is associated with an acquired immune defect, potentially resulting in failure to contain the pathogen. Elucidation of the mechanism causing the immune paresis may identify new treatment and prevention strategies.

Extended dynamic oligopolies with flexible workforce and isoelastic price function

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Akio Matsumoto

2016-11-01

Full Text Available Single-product oligopolies without product differentiation are examined with linear production, production adjustment, flexible workforce and investment costs. The price function is assumed to be hyperbolic which makes the nonlinearity of the model much stronger than in the case of linear price function examined earlier in the literature. The best responses of the firms are determined which are not monotonic in contrast to the linear case. The set of all steady states is then characterized and in the case of a duopoly it is illustrated. The asymptotical behavior of the steady states is examined by using simulation. We analyze the effects of such costs on the industry dynamics and compare them to the prediction by the well known model with hyperbolic price function and no product adjustment and investments costs.

Validity of estimated prevalence of decreased kidney function and renal replacement therapy from primary care electronic health records compared with national survey and registry data in the United Kingdom.

Science.gov (United States)

Iwagami, Masao; Tomlinson, Laurie A; Mansfield, Kathryn E; Casula, Anna; Caskey, Fergus J; Aitken, Grant; Fraser, Simon D S; Roderick, Paul J; Nitsch, Dorothea

2017-04-01

Anonymous primary care records are an important resource for observational studies. However, their external validity is unknown in identifying the prevalence of decreased kidney function and renal replacement therapy (RRT). We thus compared the prevalence of decreased kidney function and RRT in the Clinical Practice Research Datalink (CPRD) with a nationally representative survey and national registry. Among all people ≥25 years of age registered in the CPRD for ≥1 year on 31 March 2014, we identified patients with an estimated glomerular filtration rate (eGFR) primary care data have good external validity for the prevalence of decreased kidney function and RRT. © The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA.

Fractal and multifractal characteristics of swift heavy ion induced self-affine nanostructured BaF{sub 2} thin film surfaces

Energy Technology Data Exchange (ETDEWEB)

Yadav, R. P.; Mittal, A. K. [Department of Physics, University of Allahabad, Allahabad 211002 (India); Kumar, Manvendra, E-mail: kmanav@gmail.com; Pandey, A. C. [Nanotechnology Application Centre, University of Allahabad, Allahabad 211002 (India)

2015-08-15

Fractal and multifractal characteristics of self-affine surfaces of BaF{sub 2} thin films, deposited on crystalline Si 〈1 1 1〉 substrate at room temperature, were studied. Self-affine surfaces were prepared by irradiation of 120 MeV Ag{sup 9+} ions which modified the surface morphology at nanometer scale. The surface morphology of virgin thin film and those irradiated with different ion fluences are characterized by atomic force microscopy technique. The surface roughness (interface width) shows monotonic decrease with ion fluences, while the other parameters, such as lateral correlation length, roughness exponent, and fractal dimension, did not show either monotonic decrease or increase in nature. The self-affine nature of the films is further confirmed by autocorrelation function. The power spectral density of thin films surfaces exhibits inverse power law variation with spatial frequency, suggesting the existence of fractal component in surface morphology. The multifractal detrended fluctuation analysis based on the partition function approach is also performed on virgin and irradiated thin films. It is found that the partition function exhibits the power law behavior with the segment size. Moreover, it is also seen that the scaling exponents vary nonlinearly with the moment, thereby exhibiting the multifractal nature.

Pair correlation function decay in models of simple fluids that contain dispersion interactions.

Science.gov (United States)

Evans, R; Henderson, J R

2009-11-25

We investigate the intermediate-and longest-range decay of the total pair correlation function h(r) in model fluids where the inter-particle potential decays as -r(-6), as is appropriate to real fluids in which dispersion forces govern the attraction between particles. It is well-known that such interactions give rise to a term in q(3) in the expansion of [Formula: see text], the Fourier transform of the direct correlation function. Here we show that the presence of the r(-6) tail changes significantly the analytic structure of [Formula: see text] from that found in models where the inter-particle potential is short ranged. In particular the pure imaginary pole at q = iα(0), which generates monotonic-exponential decay of rh(r) in the short-ranged case, is replaced by a complex (pseudo-exponential) pole at q = iα(0)+α(1) whose real part α(1) is negative and generally very small in magnitude. Near the critical point α(1)∼-α(0)(2) and we show how classical Ornstein-Zernike behaviour of the pair correlation function is recovered on approaching the mean-field critical point. Explicit calculations, based on the random phase approximation, enable us to demonstrate the accuracy of asymptotic formulae for h(r) in all regions of the phase diagram and to determine a pseudo-Fisher-Widom (pFW) line. On the high density side of this line, intermediate-range decay of rh(r) is exponentially damped-oscillatory and the ultimate long-range decay is power-law, proportional to r(-6), whereas on the low density side this damped-oscillatory decay is sub-dominant to both monotonic-exponential and power-law decay. Earlier analyses did not identify the pseudo-exponential pole and therefore the existence of the pFW line. Our results enable us to write down the generic wetting potential for a 'real' fluid exhibiting both short-ranged and dispersion interactions. The monotonic-exponential decay of correlations associated with the pseudo-exponential pole introduces additional terms into

Essential Oil of Japanese Cedar (Cryptomeria japonica) Wood Increases Salivary Dehydroepiandrosterone Sulfate Levels after Monotonous Work.

Science.gov (United States)

Matsubara, Eri; Tsunetsugu, Yuko; Ohira, Tatsuro; Sugiyama, Masaki

2017-01-21

Employee problems arising from mental illnesses have steadily increased and become a serious social problem in recent years. Wood is a widely available plant material, and knowledge of the psychophysiological effects of inhalation of woody volatile compounds has grown considerably. In this study, we established an experimental method to evaluate the effects of Japanese cedar wood essential oil on subjects performing monotonous work. Two experiment conditions, one with and another without diffusion of the essential oil were prepared. Salivary stress markers were determined during and after a calculation task followed by distribution of questionnaires to achieve subjective odor assessment. We found that inhalation of air containing the volatile compounds of Japanese cedar wood essential oil increased the secretion of dehydroepiandrosterone sulfate (DHEA-s). Slight differences in the subjective assessment of the odor of the experiment rooms were observed. The results of the present study indicate that the volatile compounds of Japanese cedar wood essential oil affect the endocrine regulatory mechanism to facilitate stress responses. Thus, we suggest that this essential oil can improve employees' mental health.

A complexity analysis of functional interpretations

DEFF Research Database (Denmark)

Hernest, Mircea-Dan; Kohlenbach, Ulrich

2005-01-01

Summary: We give a quantitative analysis of Gödel's functional     interpretation and its monotone variant. The two have been used     for the extraction of programs and numerical bounds as well as     for conservation results. They apply both to (semi-)intuitionistic     as well as (combined...... with negative translation) classical proofs.     The proofs may be formalized in systems ranging from weak base     systems to arithmetic and analysis (and numerous fragments of     these). We give upper bounds in basic proof data on the depth,     size, maximal type degree and maximal type arity...

Visceral adiposity is associated with cytokines and decrease in lung function in women with persistent asthma

Directory of Open Access Journals (Sweden)

A.V. Capelo

2016-09-01

Full Text Available Abdominal obesity is associated with a risk of cardiovascular diseases, metabolic syndrome and decreased lung function. However, it is not known whether asthma control is influenced by the accumulation of adipose tissue in the various abdominal compartments. Objective: To determine associations among abdominal adiposity distribution, asthma control, lung function and cytokines in women. Methods and design: In this cross-sectional study of asthmatic women, data on demographic variables, comorbid conditions, disease history, anthropometric and spirometric measurements were collected. Subcutaneous (SAT and visceral (VAT adipose tissues were measured by ultrasound, and the steatosis level was obtained. Asthma control was assessed according to Global Initiative for Asthma (GINA criteria. Atopy was defined on the basis of allergen-specific Immunoglobulin E and/or skin prick testing. Cytokine levels were determined using enzyme-linked immunosorbant assays (ELISAs. Results: Eighty-three asthmatic women were included, 37% of whom had uncontrolled asthma. After controlling for variables, a negative association between asthma control and VAT and the VAT/SAT ratio was observed. VAT was negatively associated with respiratory parameters after controlling for explanatory variables. In an adjusted model, body mass index (BMI and SAT were inversely associated with the adiponectin serum level and VAT was associated with the interleukin 6 level. In conclusion, visceral obesity was negatively associated with asthma control and lung function; and positively associated with increased levels of interleukin 6 in women. We hypothesize that women should be studied as a separate group, and we suggest further studies with a control group to know if the uncontrolled asthmatic group is directly affected by visceral adipose inflammatory markers. Keywords: Asthma, Woman, Abdominal obesity, Lung function, Cytokines, Asthma control

A fiber-optic technique for the measurement of contact angle in a clearance-fit pin-loaded hole

Science.gov (United States)

Prabhakaran, R.; Naik, R. A.

1987-01-01

A fiber-optic technique for measuring contact angle during pin loading of a specimen is proposed. The experimental design and procedures for loading a 49.8-mm-diameter instrumented pin into an quasi-isotropic graphite-epoxy specimen are described. The optical fiber was located just above the surface of the pin outer diameter in order to obtain accurate pin-hole contact-angle measurements at increasing load levels. The movement of the optical fiber through the no-contact, contact, and no-contact regions is discussed; the photodiode output decreased monotonically as the fiber moved from the no-contact to the contact region and then decreased monotonically as the fiber moved from the contact region to the no-contact region. Variations in the contact angle measurements are examined as function of applied load level. The measurements are compared to contact angle values obtained using a finite element analysis and an electrical technique; it is determined that the data correlate well.

Enhanced carrier density in Nb-doped SrTiO3 thermoelectrics

KAUST Repository

Ozdogan, K.

2012-03-08

We study epitaxial SrTiO3 interfaced with Nb-doped SrTi1-x Nb x O3 (x = 0, 0.125, 0.25, 0.375, and 0.5) by full-potential density functional theory. From the electronic band structures obtained by our ab-initio calculations we determine the dependence of the induced metallicity on the Nb concentration. We obtain a monotonous increase of the carrier density with the Nb concentration. The results are confirmed by experiments for SrTi0.88Nb0.12O3 and SrTi0.8Nb0.2O3, demonstrating the predictive power and limitations of our theoretical approach. We also show that the Seebeck coefficient decreases monotonously with increasing temperature.

Enhanced carrier density in Nb-doped SrTiO3 thermoelectrics

KAUST Repository

Ozdogan, K.; Upadhyay Kahaly, M.; Sarath Kumar, S. R.; Alshareef, Husam N.; Schwingenschlö gl, Udo

2012-01-01

We study epitaxial SrTiO3 interfaced with Nb-doped SrTi1-x Nb x O3 (x = 0, 0.125, 0.25, 0.375, and 0.5) by full-potential density functional theory. From the electronic band structures obtained by our ab-initio calculations we determine the dependence of the induced metallicity on the Nb concentration. We obtain a monotonous increase of the carrier density with the Nb concentration. The results are confirmed by experiments for SrTi0.88Nb0.12O3 and SrTi0.8Nb0.2O3, demonstrating the predictive power and limitations of our theoretical approach. We also show that the Seebeck coefficient decreases monotonously with increasing temperature.

Designing the coordinate transformation function for non-magnetic invisibility cloaking

International Nuclear Information System (INIS)

Xu Xiaofei; Feng Yijun; Zhao Lin; Jiang Tian; Lu Chunhua; Xu Zhongzi

2008-01-01

An optical invisibility cloak based on a transformation approach has recently been proposed by a reduced set of material properties due to their easier implementation in reality and little need for an inhomogeneous permeability distribution, but the drawback of undesired scattering caused by the impedance mismatching at the outer boundary is unavoidable in such a cloak. By properly designing the coordinate transformation function to ensure impedance matching at the outer surface, we show that the performance of a nonmagnetic cylindrical cloak could be improved with minimized scattering fields. Using either a single high order power function or an optimized piecewise continuous power function, a cylindrical non-magnetic cloak has been designed with nearly perfect cloaking performance, which is better than those generated with a linear or a quadratic function. Due to the monotonicity of the designed power functions, the resulting cloak has no restriction on the size of the cloaking shell, therefore is suitable for both thick and thin cloaking structures.

A monotone framework for CCS

DEFF Research Database (Denmark)

Nielson, Hanne Riis; Nielson, Flemming

2009-01-01

The calculus of communicating systems, CCS, was introduced by Robin Milner as a calculus for modelling concurrent systems. Subsequently several techniques have been developed for analysing such models in order to get further insight into their dynamic behaviour. In this paper we present a static...... a finite automaton that faithfully captures the control structure of a CCS model. Each state in the automaton records a multiset of the enabled actions and appropriate transfer functions are developed for transforming one state into another. A classical worklist algorithm governs the overall construction...

A rational function based scheme for solving advection equation

International Nuclear Information System (INIS)

Xiao, Feng; Yabe, Takashi.

1995-07-01

A numerical scheme for solving advection equations is presented. The scheme is derived from a rational interpolation function. Some properties of the scheme with respect to convex-concave preserving and monotone preserving are discussed. We find that the scheme is attractive in surpressinging overshoots and undershoots even in the vicinities of discontinuity. The scheme can also be easily swicthed as the CIP (Cubic interpolated Pseudo-Particle) method to get a third-order accuracy in smooth region. Numbers of numerical tests are carried out to show the non-oscillatory and less diffusive nature of the scheme. (author)

Necessary and sufficient conditions for nonoscillatory solutions of impulsive delay differential equations

Directory of Open Access Journals (Sweden)

Shao Yuan Huang

2013-07-01

Full Text Available Monotonicity of solutions is an important property in the investigation of oscillatory behaviors of differential equations. A number of papers provide some existence criteria for eventually positive increasing solutions. However, relatively little attention is paid to eventually positive solutions that are also eventually decreasing solutions. For this reason, we establish several new and sharp oscillatory criteria for impulsive functional differential equations from this viewpoint.

The Role of Levosimendan in Patients with Decreased Left Ventricular Function Undergoing Cardiac Surgery

Directory of Open Access Journals (Sweden)

Marija Bozhinovska

2016-06-01

Full Text Available The postoperative low cardiac output is one of the most important complications following cardiac surgery and is associated with increased morbidity and mortality. The condition requires inotropic support to achieve adequate hemodynamic status and tissue perfusion. While catecholamines are utilised as a standard therapy in cardiac surgery, their use is limited due to increased oxygen consumption. Levosimendan is calcium sensitising inodilatator expressing positive inotropic effect by binding with cardiac troponin C without increasing oxygen demand. Furthermore, the drug opens potassium ATP (KATP channels in cardiac mitochondria and in the vascular muscle cells, showing cardioprotective and vasodilator properties, respectively. In the past decade, levosimendan demonstrated promising results in treating patients with reduced left ventricular function when administered in peri- or post- operative settings. In addition, pre-operative use of levosimendan in patients with severely reduced left ventricular ejection fraction may reduce the requirements for postoperative inotropic support, mechanical support, duration of intensive care unit stay as well as hospital stay and a decrease in post-operative mortality. However, larger studies are needed to clarify clinical advantages of levosimendan versus conventional inotropes.

An advanced probabilistic structural analysis method for implicit performance functions

Science.gov (United States)

Wu, Y.-T.; Millwater, H. R.; Cruse, T. A.

1989-01-01

In probabilistic structural analysis, the performance or response functions usually are implicitly defined and must be solved by numerical analysis methods such as finite element methods. In such cases, the most commonly used probabilistic analysis tool is the mean-based, second-moment method which provides only the first two statistical moments. This paper presents a generalized advanced mean value (AMV) method which is capable of establishing the distributions to provide additional information for reliability design. The method requires slightly more computations than the second-moment method but is highly efficient relative to the other alternative methods. In particular, the examples show that the AMV method can be used to solve problems involving non-monotonic functions that result in truncated distributions.

Arsenic trioxide decreases the amount and inhibits the function of regulatory T cells, which may contribute to its efficacy in the treatment of acute promyelocytic leukemia.

Science.gov (United States)

Xu, Wen; Li, Xiaoxia; Quan, Lina; Yao, Jiying; Mu, Guannan; Guo, Jingjie; Wang, Yitong

2018-03-01

Arsenic trioxide (ATO) exhibits substantial clinical efficacy in the treatment of acute promyelocytic leukemia (APL). Here, we investigated whether ATO exerts its efficacy by affecting regulatory T (Treg) cells. We determined whether ATO treatment influenced the amount and function of purified Treg cells. We also examined the effect of ATO treatment on Treg cells from APL patients. ATO treatment induced apoptosis in purified Treg cells and dampened the inhibition of effector T (Teff) cells proliferation and the secretion of cytokine by Treg cells. Treg cell levels in the peripheral blood and serum IL-10 levels were dramatically decreased in APL patients after single ATO treatment. In summary, our results show that ATO decreases the amount and inhibits the function of Treg cells, thereby enhancing Teff cell function and overall anti-tumor immunity.

Electromagnetic Transponders Indicate Prostate Size Increase Followed by Decrease During the Course of External Beam Radiation Therapy

International Nuclear Information System (INIS)

King, Benjamin L.; Butler, Wayne M.; Merrick, Gregory S.; Kurko, Brian S.; Reed, Joshua L.; Murray, Brian C.; Wallner, Kent E.

2011-01-01

Purpose: Real-time image guidance enables more accurate radiation therapy by tracking target movement. This study used transponder positions to monitor changes in prostate volume that may be a source of dosimetric and target inaccuracy. Methods and Materials: Twenty-four men with biopsy-proven T1c-T3a prostate cancer each had three electromagnetic transponders implanted transperineally. Their coordinates were recorded by the Calypso system, and the perimeter of the triangle formed by the transponders was used to calculate prostate volumes at sequential time points throughout the course of radiation therapy to a dose of 81 Gy in 1.8-Gy fractions. Results: There was a significant decrease in mean prostate volume of 10.9% from the first to the final day of radiation therapy. The volume loss did not occur monotonically but increased in most patients (75%) during the first several weeks to a median maximum on Day 7. The volume increased by a mean of 6.1% before decreasing by a mean maximum difference of 18.4% to nadir (p < 0.001 for both increase and decrease). Glandular shrinkage was asymmetric, with the apex to right base dimension varying more than twice that of the lateral dimension. For all dimensions, the mean change was <0.5 cm. Conclusion: Real-time transponder positions indicated a volume increase during the initial days of radiation therapy and then significant and asymmetric shrinkage by the final day. Understanding and tracking volume fluctuations of the prostate during radiation therapy can help real-time imaging technology perform to its fullest potential.

Epidemic spreading between two coupled subpopulations with inner structures

Science.gov (United States)

Ruan, Zhongyuan; Tang, Ming; Gu, Changgui; Xu, Jinshan

2017-10-01

The structure of underlying contact network and the mobility of agents are two decisive factors for epidemic spreading in reality. Here, we study a model consisting of two coupled subpopulations with intra-structures that emphasizes both the contact structure and the recurrent mobility pattern of individuals simultaneously. We show that the coupling of the two subpopulations (via interconnections between them and round trips of individuals) makes the epidemic threshold in each subnetwork to be the same. Moreover, we find that the interconnection probability between two subpopulations and the travel rate are important factors for spreading dynamics. In particular, as a function of interconnection probability, the epidemic threshold in each subpopulation decreases monotonously, which enhances the risks of an epidemic. While the epidemic threshold displays a non-monotonic variation as travel rate increases. Moreover, the asymptotic infected density as a function of travel rate in each subpopulation behaves differently depending on the interconnection probability.

Decreases in daily physical activity predict acute decline in attention and executive function in heart failure.

Science.gov (United States)

Alosco, Michael L; Spitznagel, Mary Beth; Cohen, Ronald; Sweet, Lawrence H; Hayes, Scott M; Josephson, Richard; Hughes, Joel; Gunstad, John

2015-04-01

Reduced physical activity (PA) may be one factor that contributes to cognitive decline and dementia in heart failure (HF). Yet, the longitudinal relationship between PA and cognition in HF is poorly understood owing to limitations of past work, including single-time assessments of PA. This is the first study to examine changes in objectively measured PA and cognition over time in HF. At baseline and 12 weeks, 57 HF patients completed psychosocial self-report measures and a neuropsychological battery and wore an accelerometer for 7 days. At baseline, HF patients spent an average of 597.83 (SD 75.91) minutes per day sedentary. Steps per day declined from baseline to the 12-week follow-up; there was also a trend for declines in moderate-vigorous PA. Regression analyses controlling for sex, HF severity, and depressive symptoms showed that decreases in light (P = .08) and moderate-vigorous (P = .04) daily PA emerged as strong predictors of declines in attention/executive function over the 12-week period, but not of memory or language. Reductions in daily PA predicted acute decline in attention/executive function in HF, but not of memory or language. Modifications to daily PA may attenuate cognitive decline, and prospective studies are needed to test this possibility. Copyright © 2015 Elsevier Inc. All rights reserved.

Behavior of annealed type 316 stainless steel under monotonic and cyclic biaxial loading at room temperature

International Nuclear Information System (INIS)

Ellis, J.R.; Robinson, D.N.; Pugh, C.E.

1978-01-01

This paper addresses the elastic-plastic behavior of type 316 stainless steel, one of the major structural alloys used in liquid-metal fast breeder reactor components. The study was part of a continuing program to develop a structural design technology applicable to advanced reactor systems. Here, behaviour of solution annealed material was examined through biaxial stress experiments conducted at room temperature under radial loadings (√3tau=sigma) in tension-torsion stress space. The effects of both stress limited monotonic loading and strain limited cyclic loading were determined on the size, shape and position of yield loci corresponding to small offset strain (10 microstrain) definition of yield. In the present work, the aim was to determine the extent to which the constitutive laws previously recommended for type 304 stainless steel are applicable to type 316 stainless steel. It was concluded that for the conditions investigated, the inelastic behavior of the two materials are qualitatively similar. Specifically, the von Mises yield criterion provides a reasonable approximation of initial yield behavior and the subsequent hardening behavior, at least under small offset definitions of yield, is to the first order kinematic in nature. (Auth.)

Decreased plasma concentrations of brain-derived neurotrophic factor (BDNF) in patients with functional hypothalamic amenorrhea.

Science.gov (United States)

Podfigurna-Stopa, Agnieszka; Casarosa, Elena; Luisi, Michele; Czyzyk, Adam; Meczekalski, Blazej; Genazzani, Andrea Riccardo

2013-09-01

Functional hypothalamic amenorrhea (FHA) is a non organic, secondary amenorrhea related to gonadotropin-releasing hormone pulsatile secretion impairment. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of survival-promoting molecules, plays an important role in the growth, development, maintenance and function of several neuronal systems. The aim of the study was the evaluation of plasma BDNF concentrations in patients with the diagnosis of FHA. We studied 85 subjects diagnosed with FHA who were compared with 10 healthy, eumenorrheic controls with normal body mass index. Plasma BDNF and serum luteinizing hormone, follicle-stimulating hormone and estradiol (E2) concentrations were measured by immunoenzymatic method (enzyme-linked immunosorbent assay). Significantly lower concentration of plasma BDNF was found in FHA patients (196.31 ± 35.26 pg/ml) in comparison to healthy controls (407.20 ± 25.71 pg/ml; p < 0.0001). In the control group, there was a strong positive correlation between plasma BDNF and serum E2 concentrations (r = 0.92, p = 0.0001) but in FHA group it was not found. Role of BDNF in FHA is not yet fully understood. There could be found studies concerning plasma BDNF concentrations in humans and animals in the literature. However, our study is one of the first projects which describes decreased plasma BDNF concentration in patients with diagnosed FHA. Therefore, further studies on BDNF in FHA should clarify the role of this peptide.

Functional diversity of macrobenthic assemblages decreases in response to sewage discharges

NARCIS (Netherlands)

Gusmao, Joao B.; Brauko, Kalina M.; Eriksson, Britas K.; Lana, Paulo C.

We analyzed the effects of sewage discharge on a subtropical estuary by comparing the functional diversity of intertidal macroinvertebrate assemblages in contaminated with non-contaminated reference areas. Functional structure was assessed using biological traits analysis (BTA) and four multivariate

Monotonicity of energy eigenvalues for Coulomb systems

International Nuclear Information System (INIS)

Englisch, R.

1983-01-01

Generalising results by earlier workers for a large class of Hamiltonians (among others, Hamiltonians of Coulomb systems) which can be written in the form H(α) = H 0 + αH' the present works shows that their eigenvalues decrease with increasing α. This result is applied to Coulomb systems in which the distances between the infinitely heavy particles are varying and also is used to obtain a completion and simplification of proof for the stability of the biexciton. (author)

Decreased Visual Function Scores on a Low Luminance Questionnaire Is Associated with Impaired Dark Adaptation.

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Yazdanie, Mohammad; Alvarez, Jason; Agrón, Elvira; Wong, Wai T; Wiley, Henry E; Ferris, Frederick L; Chew, Emily Y; Cukras, Catherine

2017-09-01

We investigate whether responses on a Low Luminance Questionnaire (LLQ) in patients with a range of age-related macular degeneration (AMD) severity are associated with their performance on focal dark adaptation (DA) testing and with choroidal thickness. Cross-sectional, single-center, observational study. A total of 113 participants older than 50 years of age with a range of AMD severity. Participants answered the LLQ on the same day they underwent DA testing using a focal dark adaptometer measuring rod intercept time (RIT). We performed univariable and multivariable analyses of the LLQ scores and age, RIT, AMD severity, subfoveal choroidal thickness [SFCT], phakic status, and best-corrected visual acuity. The primary outcome of this study was the score on the 32-question LLQ. Each item in the LLQ is designated to 1 of 6 subscales describing functional problems in low luminance: driving, emotional distress, mobility, extreme lighting, peripheral vision, and general dim lighting. Scores were computed for each subscale, in addition to a weighted total mean score. Responses from 113 participants (mean age, 76.2±9.3 years; 58.4% were female) and 113 study eyes were analyzed. Univariable analysis demonstrated that lower scores on all LLQ subscales were correlated with prolonged DA testing (longer RIT) and decreased choroidal thickness. All associations were statistically significant except for the association of choroidal thickness and "peripheral vision." The strongest association was the LLQ subscale of driving with RIT (r =-0.97, P < 0.001). Multivariable analysis for each of the LLQ subscale outcomes, adjusted for age, included RIT, with total LLQ score, "driving," "extreme lighting," and "mobility" also including choroidal thickness. In all multivariable analyses, RIT had a stronger association than choroidal thickness. This cross-sectional analysis demonstrates associations of patient-reported functional deficits, as assessed on the LLQ, with both reduced DA and

Alcoholic Hepatitis Markedly Decreases the Capacity for Urea Synthesis.

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Emilie Glavind

Full Text Available Data on quantitative metabolic liver functions in the life-threatening disease alcoholic hepatitis are scarce. Urea synthesis is an essential metabolic liver function that plays a key regulatory role in nitrogen homeostasis. The urea synthesis capacity decreases in patients with compromised liver function, whereas it increases in patients with inflammation. Alcoholic hepatitis involves both mechanisms, but how these opposite effects are balanced remains unclear. Our aim was to investigate how alcoholic hepatitis affects the capacity for urea synthesis. We related these findings to another measure of metabolic liver function, the galactose elimination capacity (GEC, as well as to clinical disease severity.We included 20 patients with alcoholic hepatitis and 7 healthy controls. The urea synthesis capacity was quantified by the functional hepatic nitrogen clearance (FHNC, i.e., the slope of the linear relationship between the blood α-amino nitrogen concentration and urea nitrogen synthesis rate during alanine infusion. The GEC was determined using blood concentration decay curves after intravenous bolus injection of galactose. Clinical disease severity was assessed by the Glasgow Alcoholic Hepatitis Score and Model for End-Stage Liver Disease (MELD score.The FHNC was markedly decreased in the alcoholic hepatitis patients compared with the healthy controls (7.2±4.9 L/h vs. 37.4±6.8 L/h, P<0.01, and the largest decrease was observed in those with severe alcoholic hepatitis (4.9±3.6 L/h vs. 9.9±4.9 L/h, P<0.05. The GEC was less markedly reduced than the FHNC. A negative correlation was detected between the FHNC and MELD score (rho = -0.49, P<0.05.Alcoholic hepatitis markedly decreases the urea synthesis capacity. This decrease is associated with an increase in clinical disease severity. Thus, the metabolic failure in alcoholic hepatitis prevails such that the liver cannot adequately perform the metabolic up-regulation observed in other stressful

Environmentally-relevant concentrations of atrazine induce non-monotonic acceleration of developmental rate and increased size at metamorphosis in Rhinella arenarum tadpoles.

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Brodeur, Julie C; Sassone, Alina; Hermida, Gladys N; Codugnello, Nadia

2013-06-01

Despite of the various studies reporting on the subject, anticipating the impacts of the widely-used herbicide atrazine on anuran tadpoles metamorphosis remains complex as increases or decreases of larval period duration are almost as frequently reported as an absence of effect. The aim of the present study was to examine the effects of environmentally-relevant concentrations of atrazine (0.1, 1, 10, 100, and 1000μg/L) on the timings of metamorphosis and body size at metamorphosis in the common South American toad, Rhinella arenarum (Anura: bufonidae). None of the atrazine concentrations tested significantly altered survival. Low atrazine concentrations in the range of 1-100μg/L were found to accelerate developmental rate in a non-monotonic U-shaped concentration-response relationship. This observed acceleration of the metamorphic process occurred entirely between stages 25 and 39; treated tadpoles proceeding through metamorphosis as control animals beyond this point. Together with proceeding through metamorphosis at a faster rate, tadpoles exposed to atrazine concentrations in the range of 1-100μg/L furthermore transformed into significantly larger metamorphs than controls, the concentration-response curve taking the form of an inverted U in this case. The no observed effect concentration (NOEC) was 0.1μg atrazine/L for both size at metamorphosis and timings of metamorphosis. Tadpoles exposed to 100μg/L 17β-estradiol presented the exact same alterations of developmental rate and body size as those treated with 1, 10 and 100μg/L of atrazine. Elements of the experimental design that facilitated the detection of alterations of metamorphosis at low concentrations of atrazine are discussed, together with the ecological significance of those findings. Copyright © 2013 Elsevier Inc. All rights reserved.

A whole-brain computational modeling approach to explain the alterations in resting-state functional connectivity during progression of Alzheimer's disease

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Murat Demirtaş

2017-01-01

Full Text Available Alzheimer's disease (AD is the most common dementia with dramatic consequences. The research in structural and functional neuroimaging showed altered brain connectivity in AD. In this study, we investigated the whole-brain resting state functional connectivity (FC of the subjects with preclinical Alzheimer's disease (PAD, mild cognitive impairment due to AD (MCI and mild dementia due to Alzheimer's disease (AD, the impact of APOE4 carriership, as well as in relation to variations in core AD CSF biomarkers. The synchronization in the whole-brain was monotonously decreasing during the course of the disease progression. Furthermore, in AD patients we found widespread significant decreases in functional connectivity (FC strengths particularly in the brain regions with high global connectivity. We employed a whole-brain computational modeling approach to study the mechanisms underlying these alterations. To characterize the causal interactions between brain regions, we estimated the effective connectivity (EC in the model. We found that the significant EC differences in AD were primarily located in left temporal lobe. Then, we systematically manipulated the underlying dynamics of the model to investigate simulated changes in FC based on the healthy control subjects. Furthermore, we found distinct patterns involving CSF biomarkers of amyloid-beta (Aβ1−42 total tau (t-tau and phosphorylated tau (p-tau. CSF Aβ1−42 was associated to the contrast between healthy control subjects and clinical groups. Nevertheless, tau CSF biomarkers were associated to the variability in whole-brain synchronization and sensory integration regions. These associations were robust across clinical groups, unlike the associations that were found for CSF Aβ1−42. APOE4 carriership showed no significant correlations with the connectivity measures.

Oxidative stress decreases functional airway mannose binding lectin in COPD.

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Hai B Tran

Full Text Available We have previously established that a defect in the ability of alveolar macrophages (AM to phagocytose apoptotic cells (efferocytosis and pathogens is a potential therapeutic target in COPD. We further showed that levels of mannose binding lectin (MBL; required for effective macrophage phagocytic function were reduced in the airways but not circulation of COPD patients. We hypothesized that increased oxidative stress in the airway could be a cause for such disturbances. We therefore studied the effects of oxidation on the structure of the MBL molecule and its functional interactions with macrophages. Oligomeric structure of plasma derived MBL (pdMBL before and after oxidation (oxMBL with 2,2'-azobis(2-methylpropionamidinedihydrochroride (AAPH was investigated by blue native PAGE. Macrophage function in the presence of pd/oxMBL was assessed by measuring efferocytosis, phagocytosis of non-typeable Haemophilus influenzae (NTHi and expression of macrophage scavenger receptors. Oxidation disrupted higher order MBL oligomers. This was associated with changed macrophage function evident by a significantly reduced capacity to phagocytose apoptotic cells and NTHi in the presence of oxMBL vs pdMBL (eg, NTHi by 55.9 and 27.0% respectively. Interestingly, oxidation of MBL significantly reduced macrophage phagocytic ability to below control levels. Flow cytometry and immunofluorescence revealed a significant increase in expression of macrophage scavenger receptor (SRA1 in the presence of pdMBL that was abrogated in the presence of oxMBL. We show the pulmonary macrophage dysfunction in COPD may at least partially result from an oxidative stress-induced effect on MBL, and identify a further potential therapeutic strategy for this debilitating disease.

Open label smoking cessation with varenicline is associated with decreased glutamate levels and functional changes in anterior cingulate cortex: preliminary findings

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Muriah Dawn Wheelock

2014-07-01

Full Text Available Rationale: Varenicline, the most effective single agent for smoking cessation, is a partial agonist at α4β2 nicotinic acetylcholine receptors. Increasing evidence implicates glutamate in the pathophysiology of addiction and one of the benefits of treatment for smoking cessation is the ability to regain cognitive control. Objective: To evaluate the effects of 12 week varenicline administration on glutamate levels in the dorsal anterior cingulate cortex (dACC and functional changes within the cognitive control network.Methods: We used single-voxel proton magnetic resonance spectroscopy (1H-MRS in the dACC and functional MRI (fMRI during performance of a Stroop color-naming task before and after smoking cessation with varenicline in 11 healthy smokers (open label design. Using the dACC as a seed region, we evaluated functional connectivity changes using a psychophysiological interaction (PPI analysis. Results: We observed a significant decrease in dACC glutamate + glutamine (Glx/Cr levels as well as significant blood oxygen level-dependent signal (BOLD decreases in the rostral ACC/medial orbitofrontal cortex and precuneus/posterior cingulate cortex. These BOLD changes are suggestive of alterations in default mode network (DMN function and are further supported by the results of the PPI analysis that revealed changes in connectivity between the dACC and regions of the DMN. Baseline measures of nicotine dependence and craving positively correlated with baseline Glx/Cr levels.Conclusions: These results suggest possible mechanisms of action for varenicline such as reduction in Glx levels in dACC and shifts in BOLD activities between large scale brain networks. They also suggest a role for ACC Glx in the modulation of behavior. Due to the preliminary nature of this study (lack of control group and small sample size, future studies are needed to replicate these findings.

High-frequency conductivity of optically excited charge carriers in hydrogenated nanocrystalline silicon investigated by spectroscopic femtosecond pump–probe reflectivity measurements

Energy Technology Data Exchange (ETDEWEB)

He, Wei [University of Birmingham, School of Physics and Astronomy, Birmingham B15 2TT (United Kingdom); Yurkevich, Igor V. [Aston University, Nonlinearity and Complexity Research Group, Birmingham B4 7ET (United Kingdom); Zakar, Ammar [University of Birmingham, School of Physics and Astronomy, Birmingham B15 2TT (United Kingdom); Kaplan, Andrey, E-mail: a.kaplan.1@bham.ac.uk [University of Birmingham, School of Physics and Astronomy, Birmingham B15 2TT (United Kingdom)

2015-10-01

We report an investigation into the high-frequency conductivity of optically excited charge carriers far from equilibrium with the lattice. The investigated samples consist of hydrogenated nanocrystalline silicon films grown on a thin film of silicon oxide on top of a silicon substrate. For the investigation, we used an optical femtosecond pump–probe setup to measure the reflectance change of a probe beam. The pump beam ranged between 580 and 820 nm, whereas the probe wavelength spanned 770 to 810 nm. The pump fluence was fixed at 0.6 mJ/cm{sup 2}. We show that at a fixed delay time of 300 fs, the conductivity of the excited electron–hole plasma is described well by a classical conductivity model of a hot charge carrier gas found at Maxwell–Boltzmann distribution, while Fermi–Dirac statics is not suitable. This is corroborated by values retrieved from pump–probe reflectance measurements of the conductivity and its dependence on the excitation wavelength and carrier temperature. The conductivity decreases monotonically as a function of the excitation wavelength, as expected for a nondegenerate charge carrier gas. - Highlights: • We study high‐frequency conductivity of excited hydrogenated nanocrystalline silicon. • Reflectance change was measured as a function of pump and probe wavelength. • Maxwell–Boltzmann transport theory was used to retrieve the conductivity. • The conductivity decreases monotonically as a function of the pump wavelength.

[Multispectral Radiation Algorithm Based on Emissivity Model Constraints for True Temperature Measurement].

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Liang, Mei; Sun, Xiao-gang; Luan, Mei-sheng

2015-10-01

Temperature measurement is one of the important factors for ensuring product quality, reducing production cost and ensuring experiment safety in industrial manufacture and scientific experiment. Radiation thermometry is the main method for non-contact temperature measurement. The second measurement (SM) method is one of the common methods in the multispectral radiation thermometry. However, the SM method cannot be applied to on-line data processing. To solve the problems, a rapid inversion method for multispectral radiation true temperature measurement is proposed and constraint conditions of emissivity model are introduced based on the multispectral brightness temperature model. For non-blackbody, it can be drawn that emissivity is an increasing function in the interval if the brightness temperature is an increasing function or a constant function in a range and emissivity satisfies an inequality of emissivity and wavelength in that interval if the brightness temperature is a decreasing function in a range, according to the relationship of brightness temperatures at different wavelengths. The construction of emissivity assumption values is reduced from multiclass to one class and avoiding the unnecessary emissivity construction with emissivity model constraint conditions on the basis of brightness temperature information. Simulation experiments and comparisons for two different temperature points are carried out based on five measured targets with five representative variation trends of real emissivity. decreasing monotonically, increasing monotonically, first decreasing with wavelength and then increasing, first increasing and then decreasing and fluctuating with wavelength randomly. The simulation results show that compared with the SM method, for the same target under the same initial temperature and emissivity search range, the processing speed of the proposed algorithm is increased by 19.16%-43.45% with the same precision and the same calculation results.

Decreased prefrontal cortical dopamine transmission in alcoholism.

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Narendran, Rajesh; Mason, Neale Scott; Paris, Jennifer; Himes, Michael L; Douaihy, Antoine B; Frankle, W Gordon

2014-08-01

Basic studies have demonstrated that optimal levels of prefrontal cortical dopamine are critical to various executive functions such as working memory, attention, inhibitory control, and risk/reward decisions, all of which are impaired in addictive disorders such as alcoholism. Based on this and imaging studies of alcoholism that have demonstrated less dopamine in the striatum, the authors hypothesized decreased dopamine transmission in the prefrontal cortex in persons with alcohol dependence. To test this hypothesis, amphetamine and [11C]FLB 457 positron emission tomography were used to measure cortical dopamine transmission in 21 recently abstinent persons with alcohol dependence and 21 matched healthy comparison subjects. [11C]FLB 457 binding potential, specific compared to nondisplaceable uptake (BPND), was measured in subjects with kinetic analysis using the arterial input function both before and after 0.5 mg kg-1 of d-amphetamine. Amphetamine-induced displacement of [11C]FLB 457 binding potential (ΔBPND) was significantly smaller in the cortical regions in the alcohol-dependent group compared with the healthy comparison group. Cortical regions that demonstrated lower dopamine transmission in the alcohol-dependent group included the dorsolateral prefrontal cortex, medial prefrontal cortex, orbital frontal cortex, temporal cortex, and medial temporal lobe. The results of this study, for the first time, unambiguously demonstrate decreased dopamine transmission in the cortex in alcoholism. Further research is necessary to understand the clinical relevance of decreased cortical dopamine as to whether it is related to impaired executive function, relapse, and outcome in alcoholism.

The loss-of-function disease-mutation G301R in the Na+/K+-ATPase α2 isoform decreases lesion volume and improves functional outcome after acute spinal cord injury in mice.

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Ellman, Ditte Gry; Isaksen, Toke Jost; Lund, Minna Christiansen; Dursun, Safinaz; Wirenfeldt, Martin; Jørgensen, Louise Helskov; Lykke-Hartmann, Karin; Lambertsen, Kate Lykke

2017-09-08

The Na + /K + -ATPases are transmembrane ion pumps important for maintenance of ion gradients across the plasma membrane that serve to support multiple cellular functions, such as membrane potentials, regulation of cellular volume and pH, and co-transport of signaling transmitters in all animal cells. The α 2 Na + /K + -ATPase subunit isoform is predominantly expressed in astrocytes, which us the sharp Na + -gradient maintained by the sodium pump necessary for astroglial metabolism. Prolonged ischemia induces an elevation of [Na + ] i , decreased ATP levels and intracellular pH owing to anaerobic metabolism and lactate accumulation. During ischemia, Na + /K + -ATPase-related functions will naturally increase the energy demand of the Na + /K + -ATPase ion pump. However, the role of the α 2 Na + /K + -ATPase in contusion injury to the spinal cord remains unknown. We used mice heterozygous mice for the loss-of-function disease-mutation G301R in the Atp1a2 gene (α 2 +/G301R ) to study the effect of reduced α 2 Na + /K + -ATPase expression in a moderate contusion spinal cord injury (SCI) model. We found that α 2 +/G301R mice display significantly improved functional recovery and decreased lesion volume compared to littermate controls (α 2 +/+ ) 7 days after SCI. The protein level of the α 1 isoform was significantly increased, in contrast to the α 3 isoform that significantly decreased 3 days after SCI in both α 2 +/G301R and α 2 +/+ mice. The level of the α 2 isoform was significantly decreased in α 2 +/G301R mice both under naïve conditions and 3 days after SCI compared to α 2 +/+ mice. We found no differences in astroglial aquaporin 4 levels and no changes in the expression of chemokines (CCL2, CCL5 and CXCL1) and cytokines (TNF, IL-6, IL-1β, IL-10 and IL-5) between genotypes, just as no apparent differences were observed in location and activation of CD45 and F4/80 positive microglia and infiltrating leukocytes. Our proof of concept study

Decreased NAA in gray matter is correlated with decreased availability of acetate in white matter in postmortem multiple sclerosis cortex.

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Li, S; Clements, R; Sulak, M; Gregory, R; Freeman, E; McDonough, J

2013-11-01

Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system (CNS) which leads to progressive neurological disability. Our previous studies have demonstrated mitochondrial involvement in MS cortical pathology and others have documented decreased levels of the neuronal mitochondrial metabolite N-acetyl aspartate (NAA) in the MS brain. While NAA is synthesized in neurons, it is broken down in oligodendrocytes into aspartate and acetate. The resulting acetate is incorporated into myelin lipids, linking neuronal mitochondrial function to oligodendrocyte-mediated elaboration of myelin lipids in the CNS. In the present study we show that treating human SH-SY5Y neuroblastoma cells with the electron transport chain inhibitor antimycin A decreased levels of NAA as measured by HPLC. To better understand the significance of the relationship between mitochondrial function and levels of NAA and its breakdown product acetate on MS pathology we then quantitated the levels of NAA and acetate in MS and control postmortem tissue blocks. Regardless of lesion status, we observed that levels of NAA were decreased 25 and 32 % in gray matter from parietal and motor cortex in MS, respectively, compared to controls. Acetate levels in adjacent white matter mirrored these decreases as evidenced by the 36 and 45 % reduction in acetate obtained from parietal and motor cortices. These data suggest a novel mechanism whereby mitochondrial dysfunction and reduced NAA levels in neurons may result in compromised myelination by oligodendrocytes due to decreased availability of acetate necessary for the synthesis of myelin lipids.

Ab initio molecular dynamics study of lithium diffusion in tetragonal Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12}

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Andriyevsky, B., E-mail: bohdan.andriyevskyy@tu.koszalin.pl [Faculty of Electronics and Computer Sciences, Koszalin University of Technology, 2 Śniadeckich Str., PL-75-453, Koszalin (Poland); Institute of Electrochemistry, Ulm University, Albert-Einstein-Allee 47, D-89069, Ulm (Germany); Doll, K. [Institute of Electrochemistry, Ulm University, Albert-Einstein-Allee 47, D-89069, Ulm (Germany); Institute of Theoretical Chemistry, Pfaffenwaldring 55, D-70569, Stuttgart (Germany); Jacob, T. [Institute of Electrochemistry, Ulm University, Albert-Einstein-Allee 47, D-89069, Ulm (Germany); Helmholtz Institute Ulm (HIU) for Electrochemical Energy Storage, Albert-Einstein-Allee 11, D-89081, Ulm (Germany)

2017-01-01

Using ab initio density functional theory the thermally-stimulated migration of lithium ions in the garnet-type material Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12} is investigated. The methods of ab initio molecular dynamics have been applied to calculate the lithium ion self-diffusion coefficient and the diffusion barriers as function of lithium ion concentration. The concentration of lithium in the initial Li{sub 7}La{sub 3}Zr{sub 2}O{sub 12} crystal unit cell is varied from 53 to 59 atoms, where 56 lithium atoms represent the stoichiometric concentration. Almost monotonous dependencies of the main characteristics on the number of lithium atoms N{sup (Li)} have been found, except for a non-monotonous peculiarity of the stoichiometric compound (N{sup (Li)} = 56). Finally, the influence of the unit cell volume change on lithium ion diffusion parameters as well as lithium ion hopping rates has been studied. - Highlights: • Partial lithium atoms subtraction from LLZO increases diffusion coefficient D{sup (Li)}. • Partial subtraction of lithium atoms from LLZO decreases activation energy E{sub a}{sup (Li)}. • Activation energy E{sub a}{sup (Li)} is the smallest for tetrahedral oxygen surrounding. • Compression of LLZO leads to a decrease of lithium ion diffusion coefficient D{sup (Li)}.

The dependence of the modulation transfer function on the blocking layer thickness in amorphous selenium x-ray detectors

International Nuclear Information System (INIS)

Hunter, David M.; Belev, Gueorgi; DeCrescenzo, Giovanni; Kasap, Safa O.; Mainprize, James G.; Rowlands, J. A.; Smith, Charles; Tuemer, Tuemay; Verpakhovski, Vladimir; Yin Shi; Yaffe, Martin J.

2007-01-01

Blocking layers are used to reduce leakage current in amorphous selenium detectors. The effect of the thickness of the blocking layer on the presampling modulation transfer function (MTF) and on dark current was experimentally determined in prototype single-line CCD-based amorphous selenium (a-Se) x-ray detectors. The sampling pitch of the detectors evaluated was 25 μm and the blocking layer thicknesses varied from 1 to 51 μm. The blocking layers resided on the signal collection electrodes which, in this configuration, were used to collect electrons. The combined thickness of the blocking layer and a-Se bulk in each detector was ∼200 μm. As expected, the dark current increased monotonically as the thickness of the blocking layer was decreased. It was found that if the blocking layer thickness was small compared to the sampling pitch, it caused a negligible reduction in MTF. However, the MTF was observed to decrease dramatically at spatial frequencies near the Nyquist frequency as the blocking layer thickness approached or exceeded the electrode sampling pitch. This observed reduction in MTF is shown to be consistent with predictions of an electrostatic model wherein the image charge from the a-Se is trapped at a characteristic depth within the blocking layer, generally near the interface between the blocking layer and the a-Se bulk

Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms.

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Becky J Proskocil

Full Text Available BACKGROUND: Epidemiological studies link organophosphorus pesticide (OP exposures to asthma, and we have shown that the OPs chlorpyrifos, diazinon and parathion cause airway hyperreactivity in guinea pigs 24 hr after a single subcutaneous injection. OP-induced airway hyperreactivity involves M2 muscarinic receptor dysfunction on airway nerves independent of acetylcholinesterase (AChE inhibition, but how OPs inhibit neuronal M2 receptors in airways is not known. In the central nervous system, OPs interact directly with neurons to alter muscarinic receptor function or expression; therefore, in this study we tested whether the OP parathion or its oxon metabolite, paraoxon, might decrease M2 receptor function on peripheral neurons via similar direct mechanisms. METHODOLOGY/PRINCIPAL FINDINGS: Intravenous administration of paraoxon, but not parathion, caused acute frequency-dependent potentiation of vagally-induced bronchoconstriction and increased electrical field stimulation (EFS-induced contractions in isolated trachea independent of AChE inhibition. However, paraoxon had no effect on vagally-induced bradycardia in intact guinea pigs or EFS-induced contractions in isolated ileum, suggesting mechanisms other than pharmacologic antagonism of M2 receptors. Paraoxon did not alter M2 receptor expression in cultured cells at the mRNA or protein level as determined by quantitative RT-PCR and radio-ligand binding assays, respectively. Additionally, a biotin-labeled fluorophosphonate, which was used as a probe to identify molecular targets phosphorylated by OPs, did not phosphorylate proteins in guinea pig cardiac membranes that were recognized by M2 receptor antibodies. CONCLUSIONS/SIGNIFICANCE: These data indicate that neither direct pharmacologic antagonism nor downregulated expression of M2 receptors contributes to OP inhibition of M2 function in airway nerves, adding to the growing evidence of non-cholinergic mechanisms of OP neurotoxicity.

Transformation of vortex structures in the wake of a sphere moving in the stratified fluid with decreasing of internal Froude number

International Nuclear Information System (INIS)

Matyushin, Pavel; Gushchin, Valentin

2011-01-01

The 3D separated, density stratified viscous fluid flows around a sphere are investigated by means of the direct numerical simulation (DNS) on the basis of the Navier-Stokes equations in the Boussinesq approximation on the supercomputers at the wide range of internal Froude (Fr) and Reynolds (Re) numbers. For DNS the Splitting on physical factors Method for Incompressible Fluid flows (SMIF) with the hybrid explicit finite difference scheme (second-order accuracy in space, minimum scheme viscosity and dispersion, monotonous) has been used. At Fr > 10 with increasing of Re we observed the flow regimes of the homogeneous viscous fluid (including the laminar-turbulent transition in the boundary layer on the sphere). With decreasing of Fr at Re < 500 the strong transformation of vortex structures in the sphere wake is demonstrated by means of the β – visualization. Thus the refined classification of the flow regimes around a sphere moving in the viscous stratified fluid is presented.

Decreased renal function and hypertension are long-term complications of extracorporeal shock wave lithotripsy

International Nuclear Information System (INIS)

Williams, C.M.; Kaude, J.V.; Newman, R.C.; Peterson, J.C.; Thomas, W.C.

1987-01-01

Quantitative radionuclide renography performed in 21 patients 17-21 months after extracorporeal shock wave lithotripsy showed a significant decrease in the percentage of effective renal plasma flow (%ERPF) of the treated kidney; in five (24%) patients the %ERPF had decreased by more than 5 percentage units. In seven (8%) of 91 patients sustained hypertension developed that required pharmacologic treatment after lithotripsy. Decreased %ERPF of a treated kidney and hypertension may be related to a Page kidney or similar process resulting from renal trauma and hemorrhage occurring as a side effect of lithotripsy. Hypertension is an important complication of lithotripsy in about 8% of patients

Theoretical research on charge exchange of uranum ions at thermal energies

International Nuclear Information System (INIS)

Bardsley, J.N.

1975-01-01

The cross section for resonant charge transfer in U + -U collisions is calculated as a function of the energy in the center-of-mass coordinate frame. The computed value decreases monotonically from approximately 300 A 2 at 0.025 eV to 100 A 2 at 50 eV. The latter value would be appropriate for ions of energy 100 eV moving through a gas of neutral atoms at thermal velocities

Functional diversity exhibits a diverse relationship with area, even a decreasing one

Science.gov (United States)

Karadimou, Elpida K.; Kallimanis, Athanasios S.; Tsiripidis, Ioannis; Dimopoulos, Panayotis

2016-01-01

The relationship between species richness and area is one of the few well-established laws in ecology, and one might expect a similar relationship with functional diversity (FD). However, only a few studies investigate the relationship between trait-based FD and area, the Functional Diversity - Area Relationship (FDAR). To examine FDAR, we constructed the species accumulation curve and the corresponding FD curve. We used plant diversity data from nested plots (1–128 m2), recorded on the Volcanic islands of Santorini Archipelagos, Greece. Six multidimensional FD indices were calculated using 26 traits. We identified a typology of FDARs depending on the facet of FD analyzed: (A) strongly positive for indices quantifying the range of functional traits in the community, (B) negative correlation for indices quantifying the evenness in the distribution of abundance in the trait space, (C) no clear pattern for indices reflecting the functional similarity of species and (D) idiosyncratic patterns with area for functional divergence. As area increases, the range of traits observed in the community increases, but the abundance of traits does not increase proportionally and some traits become dominant, implying a reliance on some functions that may be located in either the center or the periphery of the trait space. PMID:27752086

Decreasing electrical resistivity of silver along the melting boundary up to 5 GPa

Science.gov (United States)

Littleton, Joshua A. H.; Secco, Richard A.; Yong, Wenjun

2018-04-01

The electrical resistivity of Ag was experimentally measured at high pressures up to 5 GPa and at temperatures up to ∼300 K above melting. The resistivity decreased as a function of pressure and increased as a function of temperature as expected and is in very good agreement with 1 atm data. Observed melting temperatures at high pressures also agree well with previous experimental and theoretical studies. The main finding of this study is that resistivity of Ag decreases along the pressure- and temperature-dependent melting boundary, in conflict with prediction of resistivity invariance. This result is discussed in terms of the dominant contribution of the increasing energy separation between the Fermi level and 4d-band as a function of pressure. Calculated from the resistivity using the Wiedemann-Franz law, the electronic thermal conductivity increased as a function of pressure and decreased as a function of temperature as expected. The decrease in the high pressure thermal conductivity in the liquid phase as a function of temperature contrasts with the behavior of the 1 atm data.

Missense mutation Lys18Asn in dystrophin that triggers X-linked dilated cardiomyopathy decreases protein stability, increases protein unfolding, and perturbs protein structure, but does not affect protein function.

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Surinder M Singh

Full Text Available Genetic mutations in a vital muscle protein dystrophin trigger X-linked dilated cardiomyopathy (XLDCM. However, disease mechanisms at the fundamental protein level are not understood. Such molecular knowledge is essential for developing therapies for XLDCM. Our main objective is to understand the effect of disease-causing mutations on the structure and function of dystrophin. This study is on a missense mutation K18N. The K18N mutation occurs in the N-terminal actin binding domain (N-ABD. We created and expressed the wild-type (WT N-ABD and its K18N mutant, and purified to homogeneity. Reversible folding experiments demonstrated that both mutant and WT did not aggregate upon refolding. Mutation did not affect the protein's overall secondary structure, as indicated by no changes in circular dichroism of the protein. However, the mutant is thermodynamically less stable than the WT (denaturant melts, and unfolds faster than the WT (stopped-flow kinetics. Despite having global secondary structure similar to that of the WT, mutant showed significant local structural changes at many amino acids when compared with the WT (heteronuclear NMR experiments. These structural changes indicate that the effect of mutation is propagated over long distances in the protein structure. Contrary to these structural and stability changes, the mutant had no significant effect on the actin-binding function as evident from co-sedimentation and depolymerization assays. These results summarize that the K18N mutation decreases thermodynamic stability, accelerates unfolding, perturbs protein structure, but does not affect the function. Therefore, K18N is a stability defect rather than a functional defect. Decrease in stability and increase in unfolding decrease the net population of dystrophin molecules available for function, which might trigger XLDCM. Consistently, XLDCM patients have decreased levels of dystrophin in cardiac muscle.

Dependence of the subharmonic signal from contrast agent microbubbles on ambient pressure: A theoretical analysis.

Science.gov (United States)

Jiménez-Fernández, J

2018-01-01

This paper investigates the dependence of the subharmonic response in a signal scattered by contrast agent microbubbles on ambient pressure to provide quantitative estimations of local blood pressure. The problem is formulated by assuming a gas bubble encapsulated by a shell of finite thickness with dynamic behavior modeled by a nonlinear viscoelastic constitutive equation. For ambient overpressure compatible with the clinical range, the acoustic pressure intervals where the subharmonic signal may be detected (above the threshold for the onset and below the limit value for the first chaotic transition) are determined. The analysis shows that as the overpressure is increased, all harmonic components are displaced to higher frequencies. This displacement is significant for the subharmonic of order 1/2 and explains the increase or decrease in the subharmonic amplitude with ambient pressure described in previous works. Thus, some questions related to the monotonic dependence of the subharmonic amplitude on ambient pressure are clarified. For different acoustic pressures, quantitative conditions for determining the intervals where the subharmonic amplitude is a monotonic or non-monotonic function of the ambient pressure are provided. Finally, the influence of the ambient pressure on the subharmonic resonance frequency is analyzed.

Accumulation of MRI markers of cerebral small vessel disease is associated with decreased cognitive function. A study in first-ever lacunar stroke and hypertensive patients.

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Marjolein eHuijts

2013-11-01

Full Text Available Background – White matter lesions (WMLs, asymptomatic lacunar infarcts, brain microbleeds (BMBs and enlarged perivascular spaces (EPVS have been identified as silent lesions due to cerebral small vessel disease (cSVD. All these markers have been individually linked to cognitive functioning, but are also strongly correlated with each other. The combined effect of these markers on cognitive function has never been studied and would possibly provide more useful information on the effect on cognitive function. Methods – Brain MRI and extensive neuropsychological assessment were performed in 189 patients at risk for cSVD (112 hypertensive patients and 77 first-ever lacunar stroke patients. We rated the presence of any asymptomatic lacunar infarct, extensive WMLs, any deep BMB, and moderate to extensive EPVS in the basal ganglia. The presence of each marker was summed to an ordinal score between 0 and 4. Associations with domains of cognitive function (memory, executive function, information processing speed and overall cognition were analyzed with correlation analyses. Results – Correlation analyses revealed significant associations between accumulating cSVD burden and decreased performance on all cognitive domains (all p≤.001. Results remained significant for information processing speed (r=-.181, p=.013 and overall cognition (r=-.178, p=.017, after correction for age and sex. Testing of trend using linear regression analyses revealed the same results. Discussion – We tested a new approach to capture total brain damage resulting from cSVD and found that accumulation of MRI burden of cSVD is associated with decreased performance on tests of information processing speed and overall cognition, implying that accumulating brain damage is accompanied by worse cognitive functioning.

Dietary Approach to Recurrent or Chronic Hyperkalaemia in Patients with Decreased Kidney Function

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Adamasco Cupisti

2018-02-01

Full Text Available Whereas the adequate intake of potassium is relatively high in healthy adults, i.e., 4.7 g per day, a dietary potassium restriction of usually less than 3 g per day is recommended in the management of patients with reduced kidney function, especially those who tend to develop hyperkalaemia including patients who are treated with angiotensin pathway modulators. Most potassium-rich foods are considered heart-healthy nutrients with high fibre, high anti-oxidant vitamins and high alkali content such as fresh fruits and vegetables; hence, the main challenge of dietary potassium management is to maintain high fibre intake and a low net fixed-acid load, because constipation and metabolic acidosis are per se major risk factors for hyperkalaemia. To achieve a careful reduction of dietary potassium load without a decrease in alkali or fibre intake, we recommend the implementation of certain pragmatic dietary interventions as follows: Improving knowledge and education about the type of foods with excess potassium (per serving or per unit of weight; identifying foods that are needed for healthy nutrition in renal patients; classification of foods based on their potassium content normalized per unit of dietary fibre; education about the use of cooking procedures (such as boiling in order to achieve effective potassium reduction before eating; and attention to hidden sources of potassium, in particular additives in preserved foods and low-sodium salt substitutes. The present paper aims to review dietary potassium handling and gives information about practical approaches to limit potassium load in chronic kidney disease patients at risk of hyperkalaemia.

l-Theanine and caffeine improve target-specific attention to visual stimuli by decreasing mind wandering: a human functional magnetic resonance imaging study.

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Kahathuduwa, Chanaka N; Dhanasekara, Chathurika S; Chin, Shao-Hua; Davis, Tyler; Weerasinghe, Vajira S; Dassanayake, Tharaka L; Binks, Martin

2018-01-01

Oral intake of l-theanine and caffeine supplements is known to be associated with faster stimulus discrimination, possibly via improving attention to stimuli. We hypothesized that l-theanine and caffeine may be bringing about this beneficial effect by increasing attention-related neural resource allocation to target stimuli and decreasing deviation of neural resources to distractors. We used functional magnetic resonance imaging (fMRI) to test this hypothesis. Solutions of 200mg of l-theanine, 160mg of caffeine, their combination, or the vehicle (distilled water; placebo) were administered in a randomized 4-way crossover design to 9 healthy adult men. Sixty minutes after administration, a 20-minute fMRI scan was performed while the subjects performed a visual color stimulus discrimination task. l-Theanine and l-theanine-caffeine combination resulted in faster responses to targets compared with placebo (∆=27.8milliseconds, P=.018 and ∆=26.7milliseconds, P=.037, respectively). l-Theanine was associated with decreased fMRI responses to distractor stimuli in brain regions that regulate visual attention, suggesting that l-theanine may be decreasing neural resource allocation to process distractors, thus allowing to attend to targets more efficiently. l-Theanine-caffeine combination was associated with decreased fMRI responses to target stimuli as compared with distractors in several brain regions that typically show increased activation during mind wandering. Factorial analysis suggested that l-theanine and caffeine seem to have a synergistic action in decreasing mind wandering. Therefore, our hypothesis is that l-theanine and caffeine may be decreasing deviation of attention to distractors (including mind wandering); thus, enhancing attention to target stimuli was confirmed. Copyright © 2017 Elsevier Inc. All rights reserved.

Mean Occupation Function of High-redshift Quasars from the Planck Cluster Catalog

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Chakraborty, Priyanka; Chatterjee, Suchetana; Dutta, Alankar; Myers, Adam D.

2018-06-01

We characterize the distribution of quasars within dark matter halos using a direct measurement technique for the first time at redshifts as high as z ∼ 1. Using the Planck Sunyaev-Zeldovich (SZ) catalog for galaxy groups and the Sloan Digital Sky Survey (SDSS) DR12 quasar data set, we assign host clusters/groups to the quasars and make a measurement of the mean number of quasars within dark matter halos as a function of halo mass. We find that a simple power-law fit of {log} =(2.11+/- 0.01) {log}(M)-(32.77+/- 0.11) can be used to model the quasar fraction in dark matter halos. This suggests that the quasar fraction increases monotonically as a function of halo mass even to redshifts as high as z ∼ 1.

Nonlocal conductivity in type-II superconductors

International Nuclear Information System (INIS)

Mou, C.; Wortis, R.; Dorsey, A.T.; Huse, D.A.

1995-01-01

Multiterminal transport measurements on YBa 2 Cu 2 O 7 crystals in the vortex liquid regime have shown nonlocal conductivity on length scales up to 50 microns. Motivated by these results we explore the wave vector (k) dependence of the dc conductivity tensor, σ μν (k), in the Meissner, vortex lattice, and disordered phases of a type-II superconductor. Our results are based on time-dependent Ginzburg-Landau (TDGL) theory and on phenomenological arguments. We find four qualitatively different types of behavior. First, in the Meissner phase, the conductivity is infinite at k=0 and is a continuous function of k, monotonically decreasing with increasing k. Second, in the vortex-lattice phase, in the absence of pinning, the conductivity is finite (due to flux flow) at k=0; it is discontinuous there and remains qualitatively like the Meissner phase for k>0. Third, in the vortex liquid regime in a magnetic field and at low temperature, the conductivity is finite, smooth and nonmonotonic, first increasing with k at small k and then decreasing at larger k. This third behavior is expected to apply at temperatures just above the melting transition of the vortex lattice, where the vortex liquid shows strong short-range order and a large viscosity. Finally, at higher temperatures in the disordered phase, the conductivity is finite, smooth and again monotonically decreasing with k. This last, monotonic behavior applies in zero magnetic field for the entire disordered phase, i.e., at all temperatures above T c , while in a field the nonmonotonic behavior may occur in a low-temperature portion of the disordered phase

Macleaya cordata Extract Decreased Diarrhea Score and Enhanced Intestinal Barrier Function in Growing Piglets

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Gang Liu

2016-01-01

Full Text Available Macleaya cordata extract is of great scientific and practical interest to researchers, due to its antimicrobial and anti-inflammatory responses within experimental animals. This study was designed to determine the diarrhea score and innate immunity of growing piglets after they had received Macleaya cordata extract supplements. A total of 240 growing pigs were randomly assigned to one of three dietary treatments, with 8 replicates per treatment and 10 piglets per replicate. All pigs received a basal diet containing similar amounts of nutrients. The three treatments were a control (no additive, an antibiotic (200 mg/kg colistin, and the Macleaya cordata extract supplement group (40 mg/kg Macleaya cordata extract. The diarrhea score was calculated after D 28. The jejunal samples were obtained from five piglets selected randomly from each treatment on D 28. In comparison with the control group, the dietary Macleaya cordata extract and colistin group demonstrated a substantially decreased diarrhea score. The introduction of Macleaya cordata extract supplements to the diet significantly increased volumes of ZO-1 and claudin-1, particularly in comparison with the pigs in the control group (P<0.05. The findings indicate that Macleaya cordata extract does enhance intestinal barrier function in growing piglets and that it could be used as a viable substitute for antibiotics.

Gain-of-function R225W mutation in human AMPKgamma(3 causing increased glycogen and decreased triglyceride in skeletal muscle.

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Sheila R Costford

Full Text Available BACKGROUND: AMP-activated protein kinase (AMPK is a heterotrimeric enzyme that is evolutionarily conserved from yeast to mammals and functions to maintain cellular and whole body energy homeostasis. Studies in experimental animals demonstrate that activation of AMPK in skeletal muscle protects against insulin resistance, type 2 diabetes and obesity. The regulatory gamma(3 subunit of AMPK is expressed exclusively in skeletal muscle; however, its importance in controlling overall AMPK activity is unknown. While evidence is emerging that gamma subunit mutations interfere specifically with AMP activation, there remains some controversy regarding the impact of gamma subunit mutations. Here we report the first gain-of-function mutation in the muscle-specific regulatory gamma(3 subunit in humans. METHODS AND FINDINGS: We sequenced the exons and splice junctions of the AMPK gamma(3 gene (PRKAG3 in 761 obese and 759 lean individuals, identifying 87 sequence variants including a novel R225W mutation in subjects from two unrelated families. The gamma(3 R225W mutation is homologous in location to the gamma(2R302Q mutation in patients with Wolf-Parkinson-White syndrome and to the gamma(3R225Q mutation originally linked to an increase in muscle glycogen content in purebred Hampshire Rendement Napole (RN- pigs. We demonstrate in differentiated muscle satellite cells obtained from the vastus lateralis of R225W carriers that the mutation is associated with an approximate doubling of both basal and AMP-activated AMPK activities. Moreover, subjects bearing the R225W mutation exhibit a approximately 90% increase of skeletal muscle glycogen content and a approximately 30% decrease in intramuscular triglyceride (IMTG. CONCLUSIONS: We have identified for the first time a mutation in the skeletal muscle-specific regulatory gamma(3 subunit of AMPK in humans. The gamma(3R225W mutation has significant functional effects as demonstrated by increases in basal and AMP

Compact stars

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Estevez-Delgado, Gabino; Estevez-Delgado, Joaquin

2018-05-01

An analysis and construction is presented for a stellar model characterized by two parameters (w, n) associated with the compactness ratio and anisotropy, respectively. The reliability range for the parameter w ≤ 1.97981225149 corresponds with a compactness ratio u ≤ 0.2644959374, the density and pressures are positive, regular and monotonic decrescent functions, the radial and tangential speed of sound are lower than the light speed, moreover, than the plausible stability. The behavior of the speeds of sound are determinate for the anisotropy parameter n, admitting a subinterval where the speeds are monotonic crescent functions and other where we have monotonic decrescent functions for the same speeds, both cases describing a compact object that is also potentially stable. In the bigger value for the observational mass M = 2.05 M⊙ and radii R = 12.957 Km for the star PSR J0348+0432, the model indicates that the maximum central density ρc = 1.283820319 × 1018 Kg/m3 corresponds to the maximum value of the anisotropy parameter and the radial and tangential speed of the sound are monotonic decrescent functions.

Note on self-gravitating radiation in AdS spacetime

International Nuclear Information System (INIS)

Li Zhonghua; Hu Bin; Cai Ronggen

2008-01-01

Recently Vaganov and Hammersley investigated independently the equilibrium self-gravitating radiation in higher (d≥4)-dimensional, spherically symmetric anti-de Sitter space. It was found that in 4≤d≤10, there exist locally stable radiation configurations all the way up to a maximum red-shifted temperature, above which there are no solutions; there is also a maximum mass and maximum entropy configuration occurring at a higher central density than the maximal temperature configuration. Beyond their peaks the temperature, mass, and entropy undergo an infinite series of damped oscillations, which indicates the configurations in this range are unstable. In d≥11, the temperature, mass, and entropy of the self-gravitating configuration are monotonic functions of the central energy density, asymptoting to their maxima as the central density goes to infinity. In this paper we investigate the equilibrium self-gravitating radiation in higher-dimensional, plane-symmetric anti-de Sitter space. We find that there exist essential differences from the spherically symmetric case: In each dimension (d≥4), there are maximal mass (density), maximal entropy (density), and maximal temperature configurations; they do not appear at the same central energy density; the oscillation behavior appearing in the spherically symmetric case does not happen in this case; and the mass (density), as a function of the central energy density, increases first and reaches its maximum at a certain central energy density and then decreases monotonically in 4≤d≤7, while in d≥8, besides the maximum, the mass (density) of the equilibrium configuration has a minimum: the mass (density) first increases and reaches its maximum, then decreases to its minimum, and then increases to its asymptotic value monotonically. The reason causing the difference is discussed

Extracting functionally feedforward networks from a population of spiking neurons.

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Vincent, Kathleen; Tauskela, Joseph S; Thivierge, Jean-Philippe

2012-01-01

Neuronal avalanches are a ubiquitous form of activity characterized by spontaneous bursts whose size distribution follows a power-law. Recent theoretical models have replicated power-law avalanches by assuming the presence of functionally feedforward connections (FFCs) in the underlying dynamics of the system. Accordingly, avalanches are generated by a feedforward chain of activation that persists despite being embedded in a larger, massively recurrent circuit. However, it is unclear to what extent networks of living neurons that exhibit power-law avalanches rely on FFCs. Here, we employed a computational approach to reconstruct the functional connectivity of cultured cortical neurons plated on multielectrode arrays (MEAs) and investigated whether pharmacologically induced alterations in avalanche dynamics are accompanied by changes in FFCs. This approach begins by extracting a functional network of directed links between pairs of neurons, and then evaluates the strength of FFCs using Schur decomposition. In a first step, we examined the ability of this approach to extract FFCs from simulated spiking neurons. The strength of FFCs obtained in strictly feedforward networks diminished monotonically as links were gradually rewired at random. Next, we estimated the FFCs of spontaneously active cortical neuron cultures in the presence of either a control medium, a GABA(A) receptor antagonist (PTX), or an AMPA receptor antagonist combined with an NMDA receptor antagonist (APV/DNQX). The distribution of avalanche sizes in these cultures was modulated by this pharmacology, with a shallower power-law under PTX (due to the prominence of larger avalanches) and a steeper power-law under APV/DNQX (due to avalanches recruiting fewer neurons) relative to control cultures. The strength of FFCs increased in networks after application of PTX, consistent with an amplification of feedforward activity during avalanches. Conversely, FFCs decreased after application of APV

Some approximation properties of ( p , q $(p,q$ -Bernstein operators

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Shin Min Kang

2016-06-01

Full Text Available Abstract This paper is concerned with the ( p , q $(p,q$ -analog of Bernstein operators. It is proved that, when the function is convex, the ( p , q $(p,q$ -Bernstein operators are monotonic decreasing, as in the classical case. Also, some numerical examples based on Maple algorithms that verify these properties are considered. A global approximation theorem by means of the Ditzian-Totik modulus of smoothness and a Voronovskaja type theorem are proved.

The Green-Kubo formula, autocorrelation function and fluctuation spectrum for finite Markov chains with continuous time

International Nuclear Information System (INIS)

Chen Yong; Chen Xi; Qian Minping

2006-01-01

A general form of the Green-Kubo formula, which describes the fluctuations pertaining to all the steady states whether equilibrium or non-equilibrium, for a system driven by a finite Markov chain with continuous time (briefly, MC) {ξ t }, is shown. The equivalence of different forms of the Green-Kubo formula is exploited. We also look at the differences in terms of the autocorrelation function and the fluctuation spectrum between the equilibrium state and the non-equilibrium steady state. Also, if the MC is in the non-equilibrium steady state, we can always find a complex function ψ, such that the fluctuation spectrum of {φ(ξ t )} is non-monotonous in [0, + ∞)