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Sample records for monographs search monograph

  1. IARC Monographs

    DEFF Research Database (Denmark)

    Pearce, Neil E; Blair, Aaron; Vineis, Paolo

    2015-01-01

    BACKGROUND: Recently the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also the approach used to perform these evaluations. Some critics have claimed that IARC Working Groups...... carcinogens. We have examined here criticisms of the IARC classification process to determine the validity of these concerns. We review the history of IARC evaluations and describe how the IARC evaluations are performed. DISCUSSION: We conclude that these recent criticisms are unconvincing. The procedures....... This does not mean, however, that the current procedures are flawed. CONCLUSIONS: The IARC Monographs have made, and continue to make, major contributions to the scientific underpinning for societal actions to improve the public's health....

  2. Monographs and Open Access

    Directory of Open Access Journals (Sweden)

    Geoffrey Crossick

    2016-03-01

    Full Text Available This article presents the project that I led for HEFCE on the implications of OA (open access for monographs and other long-form research publications. The likely requirement that books should be OA if submitted to the REF (Research Excellence Framework after next means that OA development must be based on an understanding of the importance of the monograph in the AHSS (arts, humanities and social sciences as well as the challenges involved in making the transition to online OA. The project focused on three issues and each is summarized in turn in the article: What is the place of the monograph and other long-form publications in AHSS disciplines that makes it so important? What is happening to the monograph and is there a crisis as some suggest? What are the issues involved in moving monographs into a digital and OA environment – not just the challenge of effective business models but also many other aspects of sustaining and enhancing the qualities of the monograph? These include third-party rights, technical challenges, licences and the need for international collaboration.

  3. The Research Use of Astronomical Monographs

    Science.gov (United States)

    Abt, Helmut A.

    2014-04-01

    I explored the use of astronomical monographs used for research. After scanning 135 monographs (excluding conference proceedings and textbooks) listed in 2000-2003 issues of Physics Today and counting citations of them in 2000-2013 in ADS (Astrophysics Data System), I found that 67% of the monographs received fewer than 2 citations per year. The average citation rate for the 135 monographs is statistically the same as for ApJ papers. In contrast, only 41% of the ApJ papers produce fewer than 2 citations per year. ADS also counts the number of times each book or paper is read on-line. The average in 14 years is 181 ± 27 times for the monographs and 633 ± 47 times for ApJ papers. The total numbers of citations in 14 years for the monographs ranged from 0 to 711. I explored reasons for this range and only learned that it did not depend on (1) the numbers of book reviews published or (2) the scientific stature of the authors. I am unable to predict whether a monograph will be successful or not. The decreasing of references to monographs seems to be due to (1) monographs becoming so expensive that individuals and libraries cannot afford many of them, (2) readers seeming to prefer concise reviews, such as online searches and the Annual Reviews, and (3) most of the monographs having not been available free online.

  4. Analyzing Workforce Education. Monograph.

    Science.gov (United States)

    Texas Community & Technical Coll. Workforce Education Consortium.

    This monograph examines the issue of task analysis as used in workplace literacy programs, debating the need for it and how to perform it in a rapidly changing environment. Based on experiences of community colleges in Texas, the report analyzes ways that task analysis can be done and how to implement work force education programs more quickly.…

  5. Multiple Primary Cancer Monograph

    Science.gov (United States)

    To identify groups of cancer survivors that are at increased risk for multiple primary cancers, investigators led an effort to provide the first comprehensive population-based analysis of the risk of subsequent cancer in the U.S., resulting in a monograph.

  6. Towards iconic language for patient records, drug monographs, guidelines and medical search engines.

    Science.gov (United States)

    Lamy, Jean-Baptiste; Duclos, Catherine; Hamek, Saliha; Beuscart-Zéphir, Marie-Catherine; Kerdelhué, Gaetan; Darmoni, Stefan; Favre, Madeleine; Falcoff, Hector; Simon, Christian; Pereira, Suzanne; Serrot, Elisabeth; Mitouard, Thierry; Hardouin, Etienne; Kergosien, Yannick; Venot, Alain

    2010-01-01

    Practicing physicians have limited time for consulting medical knowledge and records. We have previously shown that using icons instead of text to present drug monographs may allow contraindications and adverse effects to be identified more rapidly and more accurately. These findings were based on the use of an iconic language designed for drug knowledge, providing icons for many medical concepts, including diseases, antecedents, drug classes and tests. In this paper, we describe a new project aimed at extending this iconic language, and exploring the possible applications of these icons in medicine. Based on evaluators' comments, focus groups of physicians and opinions of academic, industrial and associative partners, we propose iconic applications related to patient records, for example summarizing patient conditions, searching for specific clinical documents and helping to code structured data. Other applications involve the presentation of clinical practice guidelines and improving the interface of medical search engines. These new applications could use the same iconic language that was designed for drug knowledge, with a few additional items that respect the logic of the language.

  7. Monograph of Coccinia (Cucurbitaceae).

    Science.gov (United States)

    Holstein, Norbert

    2015-01-01

    This monograph deals with all 95 names described in the Cucurbitaceae genus Coccinia and recognizes 25 species. Taxonomic novelties are Cocciniaadoensisvar.aurantiaca (C.Jeffrey) Holstein, stat. nov., Cocciniasessilifoliavar.variifolia (A.Meeuse) Holstein, stat. nov., and Cocciniaadoensisvar.jeffreyana Holstein, var. nov. For the 25 species 3157 collections were examined, of which 2024 were georeferenced to produce distribution maps. All species are distributed in sub-Saharan Africa with one species, Cocciniagrandis, extending from Senegal in West Africa east to Indonesia and being naturalized on Pacific Islands, in Australia, the Caribbean, and South America. Coccinia species are dioecious creepers or climbers with simple or bifid tendrils that occupy a range of habitats from arid scrubland, woodlands to lowland rainforest and mist forest. The corolla of Coccinia species is sympetalous, usually pale yellow to orange, and 1 to 4.5 cm long. Pollination is by bees foraging for pollen or nectar. After pollination, the developing ovary often exhibits longitudinal mottling, which usually disappears during maturation. All species produce berries with a pericarp in reddish colors (orange-red through to scarlet red), hence the generic name. The globose to cylindrical fruits contain numerous grayish-beige flat to lenticular seeds. Chromosome numbers are 2n = 20, 24, and 22 + XX/XY. Many Coccinia species are used for food, either as roasted tubers, greens as spinach, or the fruits as vegetables. Medicinal value is established in Cocciniagrandis, of which leaves and sap are used against diabetes.

  8. Comparing Usage Patterns Recorded between an Electronic Reference and an Electronic Monograph Collection: The Differences in Searches and Full-Text Content Viewings

    Science.gov (United States)

    Lamothe, Alain R.

    2012-01-01

    This paper presents the results from a quantitative and systematic analysis comparing the online usage of an e-reference and an e-monograph collection. A very strong relationship exists between size and usage: the larger the collection, the greater the usage. An equally strong relationship exists between searches and viewings, meaning that the…

  9. Comparing Usage Patterns Recorded between an Electronic Reference and an Electronic Monograph Collection: The Differences in Searches and Full-Text Content Viewings

    Science.gov (United States)

    Lamothe, Alain R.

    2012-01-01

    This paper presents the results from a quantitative and systematic analysis comparing the online usage of an e-reference and an e-monograph collection. A very strong relationship exists between size and usage: the larger the collection, the greater the usage. An equally strong relationship exists between searches and viewings, meaning that the…

  10. Monograph: Concluding Remarks

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2007-01-01

    standardization, conceptual issues, up gradation, conflict of interest, patient interest and systematization. Even items for individual preferences, choice or values are not neglected. Special mention must be made of items that specify disclosure of conflict of interest both in the Developer (including the organization that develops and the individuals involved in the guideline's formulation, as well as in the sponsor or funding source (and its role in developing and/or reporting the guideline.Recommendations of CPGs and CDR panels are conflicting. One considers effectiveness, the other cost-effectiveness. However, CPGs do not adhere to established methodological standards; critical information that would attest to validity is regularly absent; explicit criteria to grade scientific evidence that supports their recommendations is absent from 82% of guidelines; 87% are not in a position to report whether a systematic literature search was performed; 67% do not describe the type of professionals used in guidelines development; and there is marked variation in the quality of guidelines. Moreover, CPG guideline layers often are conflicted in their interests. The problem can be resolved to a large extent by taking a simple step: making CPG panelists go into cost effectiveness along with recommending Guidelines. What then happens is they have to consider not only effectiveness but also costs. Effectiveness can be fudged, cost cannot. Why? Because, what is the cost is well known. Therapies in Guidelines should be recommended and graded according to whether they are Most, Moderately or Least Cost Effective. For that CPGs will have to perform an economic analysis as well. This will meet with resistance for obvious reasons. Since guideline groups cannot be kept on the straight and narrow path and till we find fool proof ways of keeping them thus, we have no option but to stress that under no circumstances they can mislead, or get misled themselves, in the name of patient advocacy, to

  11. Force Limited Vibration Testing Monograph

    Science.gov (United States)

    Scharton, Terry D.

    1997-01-01

    The practice of limiting the shaker force in vibration tests was investigated at the NASA Jet Propulsion Laboratory (JPL) in 1990 after the mechanical failure of an aerospace component during a vibration test. Now force limiting is used in almost every major vibration test at JPL and in many vibration tests at NASA Goddard Space Flight Center (GSFC) and at many aerospace contractors. The basic ideas behind force limiting have been in the literature for several decades, but the piezo-electric force transducers necessary to conveniently implement force limiting have been available only in the last decade. In 1993, funding was obtained from the NASA headquarters Office of Chief Engineer to develop and document the technology needed to establish force limited vibration testing as a standard approach available to all NASA centers and aerospace contractors. This monograph is the final report on that effort and discusses the history, theory, and applications of the method in some detail.

  12. Monograph on prospective developments in oceanology

    Science.gov (United States)

    Monin, A. S.

    1986-01-01

    Excerpts from a chapter of a monograph, Oceanology in the Year 2000, which has been prepared for publication at the USSR Academy of Sciences' Institute of Oceanology, is presented. The author of this chapter is A. S. Morin, corresponding member of the USSR Academy of Sciences and director of the oceanology institute. The monograph is said to be the collective work of a group of specialists. Monin views prospective developments of oceanology and oceanology related research and development, technology and expedition research.

  13. Preface to the third monograph

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2004-05-01

    Full Text Available Fashions come and go. Filmstars have their hey days and sink into oblivion. Technological gadgets become outdated sometimes even before they enter the market. Everyone wants the latest in TVs, computers, mobiles, cars, household appliances, industrial machinery, the works.We want to hear the latest news. Nobody prefers to read yesterday's newspaper today out of choice. We also want to read the latest edition of a book, and look up recent references and research work.We want the latest in treatments as well. The most recent is always considered an advancement over what was available earlier. Newer therapies, newer investigations, newer procedures.But, at the some time, we want to go to the senior consultant. And, given a choice, the older the better. Even elsewhere, we do not go to the junior most person to solve our problems if we can approach the senior man, and he is amenable. The recent graduate or postgraduate has the latest information, but it is the senior man who sits on the panel of examiners.We want the most recent in some cases, and the older and more experienced in others. Why should this happen? How should we handle our great need to update our knowledge on the latest, and yet not neglect the old and time-tested?This dilemma occurs in the research field as well, and psychiatry is no exception.What can be a healthy way of resolving this issue is the subject matter of this monograph.

  14. Preface to the seventh monograph

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2005-01-01

    Full Text Available Like all good neighbours, competing schools of psychiatry claw at each other. Like all good samaritans, some people try to play arbiters and douse the fires. The tradition of fights and retaliation is not new to psy­chiatry, neither is it unique to the branch. Competing schools of thought exist almost everywhere. And it is tempting to say that the more intellec­tually robust a field, the greater the controversies and fights in it.In fact if intellectuals were to come together and not voice differences, either they are not intellectuals, or they have no opinions. (Or they may be simply scared, or silenced for other reasons.Ofcourse we must note that while in other fields of thought there can be controversies, there is one essential difference. They may not be dealing with patients and their lives. And to that the corollary is that psychiatric controversies should not be carried out at the expense of patient welfare.Having said that, let us also note that when there are fights, arbiters become very active. As do advocates, of one or the other approach.In this monograph we have tried to act the arbiters. Maybe because it is appropriate. Maybe also because that's the only thing we can do (and may be do well: atleast that's what we would love to believe.Why not advocates ? Well, for one, there are so many already. For another, we run the risk of doing a poor job of it.Not that we have necessarily done a good job of being arbiters.

  15. 21 CFR 330.11 - NDA deviations from applicable monograph.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false NDA deviations from applicable monograph. 330.11... EFFECTIVE AND NOT MISBRANDED Administrative Procedures § 330.11 NDA deviations from applicable monograph. A new drug application requesting approval of an OTC drug deviating in any respect from a monograph that...

  16. Bibliometrics of NIHR HTA monographs and their related journal articles.

    Science.gov (United States)

    Royle, Pamela; Waugh, Norman

    2015-02-18

    A bibliometric analysis of the UK National Institute for Health Research (NIHR) Health Technology Assessment (HTA) monographs and their related journal articles by: (1) exploring the differences in citations to the HTA monographs in Google Scholar (GS), Scopus and Web of Science (WoS), and (2) comparing Scopus citations to the monographs with their related journal articles. A study of 111 HTA monographs published in 2010 and 2011, and their external journal articles. Citations to the monographs in GS, Scopus and WoS, and to their external journal articles in Scopus. The number of citations varied among the three databases, with GS having the highest and WoS the lowest; however, the citation-based rankings among the databases were highly correlated. Overall, 56% of monographs had a related publication, with the highest proportion for primary research (76%) and lowest for evidence syntheses (43%). There was a large variation in how the monographs were cited, compared to journal articles, resulting in more frequent problems, with unlinked citations in Scopus and WoS. When comparing differences in the number of citations between monograph publications with their related journal articles from the same project, we found that monographs received more citations than their journal articles for evidence syntheses and methodology projects; by contrast, journal articles related to primary research monographs were more highly cited than their monograph. The numbers of citations to the HTA monographs differed considerably between the databases, but were highly correlated. When a HTA monograph had a journal article from the same study, there were more citations to the journal article for primary research, but more to the monographs for evidence syntheses. Citations to the related journal articles were more reliably recorded than citations to the HTA monographs. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please

  17. When Teachers Lead. UCEA Monograph Series.

    Science.gov (United States)

    Astuto, Terry A., Ed.

    This document contains six chapters that examine the role of teacher leadership in the school-restructuring process. Chapter 1, "When--Teachers Lead" (Bruce S. Cooper), provides a general introduction to the content and purpose of the monograph. Chapter 2, "When--Teachers Share School-Level Decision-Making" (Sharon Conley and Justo Robles),…

  18. 76 FR 51034 - Availability of Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy...

    Science.gov (United States)

    2011-08-17

    ... HUMAN SERVICES Availability of Draft NTP Monograph on Potential Developmental Effects of Cancer... Monograph AGENCY: Division of the National Toxicology Program (DNTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health. ACTION: Availability of Draft Monograph; Request...

  19. ‘The Returned’: on the future of monographic books

    Directory of Open Access Journals (Sweden)

    Mercedes Bunz

    2014-04-01

    Full Text Available This article evaluates the current state of academic book publishing based on the findings of the Hybrid Publishing Lab's business model research. With students relying more and more on Google and Wikipedia, the role of books within today's university studies is a difficult one. From the perspective of publishers, open access (OA embracing the digital is seen as one potential way to bridge this gap between online search engines and traditional monographs. To illustrate this further, the article delivers an overview of its findings, which highlight changes in academic publishing: publishers have switched their emphasis from delivering a product to creating a service, whereby the author rather than the reader becomes their most focused-on customer. Research frameworks, funding and conventions about academic careers, however, often still need to adjust to this new development. If these frameworks acknowledge and foster OA publishing, and new experiments with collaborative book productions flourish, the monograph will have a future.

  20. Report on carcinogens monograph on 1-bromopropane.

    Science.gov (United States)

    2013-09-01

    The National Toxicology Program conducted a cancer evaluation on 1 bromopropane for possible listing in the Report on Carcinogens (RoC). The cancer evaluation is captured in the RoC monograph, which was peer reviewed in a public forum. The monograph consists of two components: (Part 1) the cancer evaluation, which reviews the relevant scientific information, assesses its quality, applies the RoC listing criteria to the scientific information, and provides the NTP recommendation for listing status for 1 bromopropane in the RoC, and (Part 2) the substance profile proposed for the RoC, containing the NTP's listing status recommendation, a summary of the scientific evidence considered key to reaching that decision, and data on properties, use, production, exposure, and Federal regulations and guidelines to reduce exposure to 1-bromopropane. This monograph provides an assessment of the available scientific information on 1 bromopropane, including human exposure and properties, disposition and toxicokinetics, cancer studies in experimental animals, and studies of mechanisms and other related effects, including relevant toxicological effects, genetic toxicology, and mechanisms of carcinogenicity. From this assessment, the NTP recommended that 1 bromopropane be listed as reasonably anticipated to be a human carcinogen in the RoC based on sufficient evidence from studies in experimental animals, which found inhalation exposure to 1-bromopropane caused skin tumors in male rats, large intestine tumors in female and male rats, and lung tumors in female mice. Also noted was that 1 bromopropane, either directly or via reactive metabolites, caused molecular alterations that typically are associated with carcinogenesis, including genotoxicity, oxidative stress, and glutathione depletion. These alterations, observed in mainly in vitro and toxicity studies in rodents, are relevant to possible mechanisms of human carcinogenicity and support the relevance of the cancer studies in

  1. Report on carcinogens monograph on cumene.

    Science.gov (United States)

    2013-09-01

    The National Toxicology Program conducted a cancer evaluation on cumene for possible listing in the Report on Carcinogens (RoC). The cancer evaluation is captured in the RoC monograph, which was peer reviewed in a public forum. The monograph consists of two components: (Part 1) the cancer evaluation, which reviews the relevant scientific information, assesses its quality, applies the RoC listing criteria to the scientific information, and provides the NTP recommendation for listing status for cumene in the RoC, and (Part 2) the substance profile proposed for the RoC, containing the NTP's listing status recommendation, a summary of the scientific evidence considered key to reaching that decision, and data on properties, use, production, exposure, and Federal regulations and guidelines to reduce exposure to cumene. This monograph provides an assessment of the available scientific information on cumene, including human exposure and properties, disposition and toxicokinetics, cancer studies in experimental animals, and studies of mechanisms and other related effects, including relevant toxicological effects, genetic toxicology, and mechanisms of carcinogenicity. From this assessment, the NTP recommended that cumene be listed as reasonably anticipated to be a human carcinogen in the RoC based on sufficient evidence from studies in experimental animals, which found that cumene exposure caused lung tumors in male and female mice and liver tumors in female mice. Several proposed mechanisms of carcinogenesis support the relevance to humans of the lung and liver tumors observed in experimental animals. Specifically, there is evidence that humans and experimental animals metabolize cumene through similar metabolic pathways. In addition, mutations of the K-ras oncogene and p53 tumor-suppressor gene observed in cumene-induced lung tumors in mice, along with altered expression of many other genes, resemble molecular alterations found in human lung and other cancers.

  2. Creative Drama as a Resource, K-12. Language Arts Monograph.

    Science.gov (United States)

    Sharpham, John R.

    Defining creative drama as a teaching process that uses the inherent ability of each person to explore ideas, behavior patterns, and human relationships, this monograph is designed to help teachers create a working environment within which this process can be most productive. Various sections of the monograph provide information about how creative…

  3. [Leon Daraszkiewicz and his monograph on hebephrenia].

    Science.gov (United States)

    Marcinowski, Filip

    2012-01-01

    Leon Daraszkiewicz (1866-1931) was a Polish psychiatrist, a pupil and co-worker of E. Kraepelin and V. Tsiz on the University of Dorpat (now Tartu, Estonia), the author of highly regarded monograph on hebephrenia (1891). In his work on the basis of over 20 case histories, he described a natural history of hebephrenia and his own views on its aetiology and prognosis. Hebephrenia as described by Daraszkiewicz, served as a clinical model for the Kraepelinian concept of dementia praecox. In the article, the life and career of Daraszkiewicz is covered, with particular emphasis on the role of his doctoral dissertation on hebephrenia in the history of the concept of schizophrenia.

  4. Monograph for using paleoflood data in Water Resources Applications

    Science.gov (United States)

    Swain, R.E.; Jarrett, R.D.

    2004-01-01

    The Environmental and Water Resources Institute (EWRI) Technical Committee on Surface Water Hydrology is sponsoring a Task Committee on Paleoflood Hydrology to prepare a monograph entitled, "Use of Paleoflood and Historical Data in Water Resources Applications." This paper introduces the subject of paleoflood hydrology and discusses the topics, which are expected to be included in the monograph. The procedure for preparing and reviewing the monograph will also be discussed. The paleoflood hydrology monograph will include a discussion of types of hydrologic and paleoflood data, paleostage indicators, flood chronology, modeling methods, interpretation issues, water resources applications and case studies, and research needs. Paleoflood data collection and analysis techniques will be presented, and various applications in water-resources investigations will be provided. An overview of several flood frequency analysis approaches, which consider historical and paleoflood data along with systematic streamflow records, will be presented. The monograph is scheduled for completion and publication in 2001. Copyright ASCE 2004.

  5. 77 FR 48995 - Draft National Toxicology Program (NTP) Monograph on Developmental Effects and Pregnancy Outcomes...

    Science.gov (United States)

    2012-08-15

    ... HUMAN SERVICES National Institutes of Health Draft National Toxicology Program (NTP) Monograph on... of the draft monograph. Topic: Peer review of the draft NTP Monograph on Developmental Effects and... scheduled for oral public comment. The NTP also invites written comments on the draft monograph, submission...

  6. MSM 2010 Theme Monograph Psychopharmacology Today

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2010-01-01

    Full Text Available This theme monograph is called Psychopharmacology Today. It has some notable contributions on issues in psychopharmacology.MSM 2010 is dedicated to the fond memory of Dr V.N. Bagadia, who headed our Hon International Editorial Advisory Board. See Dedication, " Dr Bagadia, Sir, is no more"(p3.Thomas L. Schwartz, M.D. Associate Professor of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA writes an editorial on, "Psychopharmacology today: where are we and where do we go from here?"(p6.Ajai R. Singh, MD. Editor, Mens Sana Monographs, writes the second editorial on, "Modern medicine: towards prevention, cure, well-being and longevity"(p17.Sannidhya Varma, Himanshu Sareen and J.K. Trivedi from CSM Medical University, Lucknow, India, write on, "The Geriatric Population and Psychiatric Medication"(p30.Amresh Shrivastava from The University of Western Ontario, Department of Psychiatry and Megan E. Johnston from University of Toronto, Department of Psychology, write on, "Weight Gain in Psychiatric Treatment: Risks, Implications, and Strategies for Prevention and Management"(p53.Avinash De Sousa, M.D. Consultant Psychiatrist& Psychotherapist, Mumbai, writes on, "The Pharmacotherapy of Alcohol Dependence: A State of the Art Review"(p69. Late B. M. Tripathi, M.D. Professor, Department of Psychiatry and National Drug Dependence and Treatment Center, All India Institute of Medical Sciences, and Pradipta Majumder, MBBS, Resident, Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, write on, "Lactating Mother and Psychotropic Drugs"(p83.K.S. Latha PhD. Associate Professor, Department of Psychiatry, KMC Hospital, Manipal University, writes on, "The Noncompliant Patient in Psychiatry: The Case For and Against Covert/Surreptitious Medication"(p96. Neha Khetrapal, [M.A. Cognitive Science], Centre of Excellence "Cognitive Interaction Technology" (CITEC And Faculty of Psychology& Sport Sciences, University of Bielefeld, Germany

  7. Could EU herbal monographs contribute to Malta's treatment armamentarium?

    Science.gov (United States)

    Micallef, B; Attard, E; Serracino-Inglott, A; Borg, J J

    2015-03-15

    Ten years have passed since Directive 2004/24/EC regulating herbal medicinal products across the EU were published. The directive created the Committee on Herbal Medicinal Products within the European Medicines Agency whose remit includes the creation and publishing of official EU monographs on herbal medicinal products. These monographs include the official uses of the products and their evidence for efficacy and safety. To this effect, we are interested in analysing the potential impact herbal product EU monographs could have on the therapeutic treatment options available for prescribers in Malta. Therefore our aim was two-fold. First, to rationalise the spread of indications of the herbal substances listed in the community herbal monograph inventory and subsequently determine if these herbal substances could potentially contribute to the treatment options available in our local scenario (Malta). 128 EU monographs were analysed resulting in a total of 230 indications which subsequently codified into 42 unique ATC codes. The Malta Medicines List contains 1456 unique ATC codes. Comparative analysis of the Malta Medicines List revealed that the 21 therapeutic areas had 4 or less pharmaceutically used substances (5th level ATC codes) registered and therefore in our opinion are areas with limited therapeutic choice. The following 4 therapeutic areas, A05 bile and liver therapy, A13 tonics, A15 appetite stimulants and D03 preparations for treatment of wounds and ulcers, could potentially benefit from the registration of herbal medicinal products according to the EU herbal monographs. If such registration is effected the aforementioned areas would no longer be considered limited because more than 4 therapeutic choices would be available to prescribers. This study is the first study across the EU to analyse the potential impact of published EU herbal monographs on therapeutic coverage in an EU member state and confirms the notion that herbal products could potentially

  8. A monograph of Otidea (Pyronemataceae, Pezizomycetes).

    Science.gov (United States)

    Olariaga, I; Van Vooren, N; Carbone, M; Hansen, K

    2015-12-01

    The easily recognised genus Otidea is subjected to numerous problems in species identification. A number of old names have undergone various interpretations, materials from different continents have not been compared and misidentifications occur commonly. In this context, Otidea is monographed, based on our multiple gene phylogenies assessing species boundaries and comparative morphological characters (see Hansen & Olariaga 2015). All names combined in or synonymised with Otidea are dealt with. Thirty-three species are treated, with full descriptions and colour illustrations provided for 25 of these. Five new species are described, viz. O. borealis, O. brunneoparva, O. oregonensis, O. pseudoleporina and O. subformicarum. Otidea cantharella var. minor and O. onotica var. brevispora are elevated to species rank. Otideopsis kaushalii is combined in the genus Otidea. A key to the species of Otidea is given. An LSU dataset containing 167 sequences (with 44 newly generated in this study) is analysed to place collections and determine whether the named Otidea sequences in GenBank were identified correctly. Fourty-nine new ITS sequences were generated in this study. The ITS region is too variable to align across Otidea, but had low intraspecific variation and it aided in species identifications. Thirty type collections were studied, and ITS and LSU sequences are provided for 12 of these. A neotype is designated for O. cantharella and epitypes for O. concinna, O. leporina and O. onotica, along with several lectotypifications. The apothecial colour and shape, and spore characters are important for species identification. We conclude that to distinguish closely related or morphologically similar species, a combination of additional features are needed, i.e. the shape of the paraphyses, ectal excipulum structure, types of ectal excipulum resinous exudates and their reactions in Melzer's reagent and KOH, tomentum and basal mycelium colours and exudates. The KOH reaction of

  9. 75 FR 30838 - Drometrizole Trisiloxane Eligibility for Potential Inclusion in Sunscreen Monograph; Over-the...

    Science.gov (United States)

    2010-06-02

    ... Eligibility for Potential Inclusion in Sunscreen Monograph; Over-the-Counter Sunscreen Drug Products for Human... monograph. We reviewed a time and extent application (TEA) for drometrizole trisiloxane and determined that it is eligible to be considered for inclusion in our OTC drug monograph system. We will evaluate the...

  10. Regulation and Education: Strategies for Solving the Bottle Feeding Problem. Monograph Series No. 4.

    Science.gov (United States)

    Greiner, Ted

    This book is the fourth monograph in the Cornell International Monograph Series, the second in the series to deal with the question of breast versus bottle feeding. The introduction to the monograph discusses the shift from breast to bottle feeding in both industrialized and developing nations. Some of the reasons for, and consequences of, the…

  11. 78 FR 4419 - Draft Report on Carcinogens Monographs for 1-Bromopropane and Cumene; Availability of Documents...

    Science.gov (United States)

    2013-01-22

    ... HUMAN SERVICES National Institutes of Health Draft Report on Carcinogens Monographs for 1-Bromopropane... meeting of the Draft Report on Carcinogens (RoC) Monographs for 1-Bromopropane and Cumene. These documents....m. until adjournment, approximately 2:00 p.m. EDT. Document Availability: Draft monographs will...

  12. The monographic sociology from the perspective of American critical ethnography

    Directory of Open Access Journals (Sweden)

    Șerban Văetiși

    2013-11-01

    Full Text Available The paper attempts to reconsider some theoretical and methodological principles practiced by the Bucharest School of Sociology by invoking some concepts put forward by the so called Critical Ethnography. It considers three major ideas of the Monographic Sociology, that can be also found as theoretical assumptions of the postmodern critical ethnographic theory, in an interesting parallel that can be, thus, reconstructed and further suggested as useful paradigm within current approaches in social sciences and policies: interdisciplinarity, activism and criticism. The paper concludes on the contribution that the Monographic School may have to the current social theory, research and policy developed today in Romania.

  13. A foundation monograph of Convolvulus L. (Convolvulaceae).

    Science.gov (United States)

    Wood, John R I; Williams, Bethany R M; Mitchell, Thomas C; Carine, Mark A; Harris, David J; Scotland, Robert W

    2015-01-01

    .R.I.Wood & R.W.Scotland, comb. et stat. nov., Convolvuluscalvertiisubsp.ruprechtii (Boiss.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvuluscephalopodussubsp.bushiricus (Bornm.) J.R.I.Wood & R.W.Scotland, stat. nov. The status of various infraspecific taxa is clarified and numerous taxa are lectotypified. This account represents a new initiative in terms of taxonomic monography, being an attempt to bring together the global approach of the traditional monograph with the more pragmatic and identification-focussed approach of most current floras while at the same time being informed by insights from molecular systematics.

  14. A monograph of the Vochysiaceae ̶ I. Salvertia and Vochysia

    NARCIS (Netherlands)

    Stafleu, F.A.

    1948-01-01

    This publication is intended to be the first part of a taxonomic monograph of the family Vochysiaceae and deals with the genera Salvertia and Vochysia. Since Warming’s excellent treatise of the Brazilian species of this family in the Flora Brasiliensis (Vol. XIII, II,1875) a large number of new spec

  15. The Chemistry of Food Dyes. Palette of Color Monograph Series.

    Science.gov (United States)

    Epp, Dianne N.

    Dyes aren't just for fabrics--colorants have been added to food for centuries to enhance its appearance. This monograph and teaching guide investigates both the compounds that give foods their natural color and synthetic colorants currently approved for use in foods. Problem-solving inquiry based activities involve high school level students in…

  16. The Chemistry of Food Dyes. Palette of Color Monograph Series.

    Science.gov (United States)

    Epp, Dianne N.

    Dyes aren't just for fabrics--colorants have been added to food for centuries to enhance its appearance. This monograph and teaching guide investigates both the compounds that give foods their natural color and synthetic colorants currently approved for use in foods. Problem-solving inquiry based activities involve high school level students in…

  17. Safety in Team Sports. Sports Safety Series, Monograph No. 3.

    Science.gov (United States)

    Borozne, Joseph, Ed.; And Others

    This monograph examines methods of promoting safe practices in the conduct of selected team sports with the aim of reducing and eliminating the occurrance of injuries. The team sports discussed are baseball and softball, basketball, field hockey, tackle football, touch and flag football, ice hockey, lacrosse, and soccer. (MJB)

  18. Use of High Throughput Screening Data in IARC Monograph ...

    Science.gov (United States)

    Purpose: Evaluation of carcinogenic mechanisms serves a critical role in IARC monograph evaluations, and can lead to “upgrade” or “downgrade” of the carcinogenicity conclusions based on human and animal evidence alone. Three recent IARC monograph Working Groups (110, 112, and 113) pioneered analysis of high throughput in vitro screening data from the U.S. Environmental Protection Agency’s ToxCast program in evaluations of carcinogenic mechanisms. Methods: For monograph 110, ToxCast assay data across multiple nuclear receptors were used to test the hypothesis that PFOA acts exclusively through the PPAR family of receptors, with activity profiles compared to several prototypical nuclear receptor-activating compounds. For monographs 112 and 113, ToxCast assays were systematically evaluated and used as an additional data stream in the overall evaluation of the mechanistic evidence. Specifically, ToxCast assays were mapped to 10 “key characteristics of carcinogens” recently identified by an IARC expert group, and chemicals’ bioactivity profiles were evaluated both in absolute terms (number of relevant assays positive for bioactivity) and relative terms (ranking with respect to other compounds evaluated by IARC, using the ToxPi methodology). Results: PFOA activates multiple nuclear receptors in addition to the PPAR family in the ToxCast assays. ToxCast assays offered substantial coverage for 5 of the 10 “key characteristics,” with the greates

  19. A monograph of the Vochysiaceae ̶ I. Salvertia and Vochysia

    NARCIS (Netherlands)

    Stafleu, F.A.

    1948-01-01

    This publication is intended to be the first part of a taxonomic monograph of the family Vochysiaceae and deals with the genera Salvertia and Vochysia. Since Warming’s excellent treatise of the Brazilian species of this family in the Flora Brasiliensis (Vol. XIII, II,1875) a large number of new

  20. Baby Boom Equals Career Bust. Monographs on Career Education.

    Science.gov (United States)

    Moore, Charles Guy

    Presenting the Baby Boom (1946-1965) as both a potential social problem and opportunity for American leadership, this monograph discusses the following aspects of this population concern: (1) its immediate and long-term impact on career opportunities for those college graduates who make up the baby boom generation; (2) its impact on those whose…

  1. Sex Bias in ASAT? ACER Research Monograph No. 24.

    Science.gov (United States)

    Adams, Raymond J.

    The Australian Scholastic Test (ASAT) was first used as a moderating device in the Australian Capitol Territory in 1977. Differences have been observed in the average performance of males and females on the test. The study reported in this monograph investigated the nature and origin of the score differences recorded for ASAT The research focused…

  2. Systematic organization of medicinal plant information: a monograph template proposal

    Directory of Open Access Journals (Sweden)

    Ana C.B. Carvalho

    2014-01-01

    Full Text Available The use of medicinal plants in Brazil is widespread and is supported by public policies; it has the objective of providing the population with safe and effective herbal medicines of adequate quality. An action in these policies is to develop medicinal plant monographs to gather published information and decide which medicinal plants should be financed by the Brazilian government and distributed by the public health system. Currently, the monographs published worldwide do not present unified information regarding medicinal plants, and generally, they do not cover enough requirements for herbal medicine registration. The aim of this study is to develop a monograph model with standardized information not only about botany, agronomy, quality control, safety, and efficacy but also about relating regulatory aspects that support herbal medicine regulation. The development of standardized monographs favors the fast authorization and distribution of herbal medicines in the public system. The model also points out the lacking studies that should be carried out to supplement the necessary regulatory information of medicinal plants.

  3. Assessing Creativity: A Guide for Educators. Research Monograph Series.

    Science.gov (United States)

    Treffinger, Donald J.; Young, Grover C.; Selby, Edwin C.; Shepardson, Cindy

    This monograph deals specifically with the challenge of recognizing or assessing creativity. Following an introductory chapter, chapter 2 focuses on definitions and characteristics of creativity to help clarify the nature and meaning of creativity and creative thinking, and to consider the implications of those definitions for assessment. The…

  4. The significance of field work in monographic studies

    Science.gov (United States)

    The focus of this paper is to document the clear and obvious advantages of field work for monographic studies. These advantages include: 1) ability to understand published distributions better and greatly expand these data, 2) access to taxonomic data obscured on herbarium sheets (as colors, odors, ...

  5. State Defense Force Monograph Series. Winter 2006, Medical Support Teams

    Science.gov (United States)

    2006-01-01

    assets for mobile support teams, labs, immunizations, latent TB screening, and post-deployment assessments.” (COL Eric Allely, Maryland State Surgeon...infarctions ! Diabetes ! Mental health problems ! Hypertension ! Diarrhea ! Heat injuries 30 State Defense Force Monograph Series, Summer 2006...for dysentery and vomiting ! Viral meningitis ! Injuries due to off-site fighting ! Tuberculosis ! HIV ! Special medical needs. See Figures 3

  6. A foundation monograph of Convolvulus L. (Convolvulaceae)

    Science.gov (United States)

    Wood, John R.I.; Williams, Bethany R.M.; Mitchell, Thomas C.; Carine, Mark A.; Harris, David J.; Scotland, Robert W.

    2015-01-01

    ., Convolvulus rottlerianus subsp. stocksii (Boiss.) J.R.I.Wood & R.W.Scotland, comb. et stat. nov., Convolvulus calvertii subsp. ruprechtii (Boiss.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus cephalopodus subsp. bushiricus (Bornm.) J.R.I.Wood & R.W.Scotland, stat. nov. The status of various infraspecific taxa is clarified and numerous taxa are lectotypified. This account represents a new initiative in terms of taxonomic monography, being an attempt to bring together the global approach of the traditional monograph with the more pragmatic and identification-focussed approach of most current floras while at the same time being informed by insights from molecular systematics. PMID:26140023

  7. Monograph use at an academic health sciences library: the first three years of shelf life

    Science.gov (United States)

    Blecic, Deborah D.

    2000-01-01

    Objective: To study the circulation of monographs during the first three years of shelf life at an academic health sciences library. Method: A record was kept of monographs added to the circulating collection from mid-1994 to mid-1995. After three years, each monograph was located and the number of times it circulated during the first, second, and third year of shelf life determined by counting checkout stamps on the circulation slip. Results: Of the 1,958 monographs studied, 1,674 had complete data for the first three years of shelf life. Of those 1,674 titles, 81.48% circulated at least once. A total of 7,659 circulations were recorded; 38.69% occurred in the first year of shelf life, 32.37% in the second year, and 28.95% in the third year. The data did not fit the well-known 80/20 rule. Instead, approximately 38% of monographs accounted for 80% of circulation. A small percentage, 2.21%, of monographs accounted for a substantial percentage of circulation, 21.84%. Conclusions: A large percentage of the monographs circulated and use did not decline sharply with age within the first three years of shelf life, indicating a high demand for monographs at this academic health sciences library. These results, combined with the findings of earlier studies, suggested two possibilities. First, academic health sciences libraries might exhibit use of a higher percentage of monograph acquisitions than other types of libraries; or, second, a low monograph-to-user ratio might result in a higher percentage of monographs being used. Perhaps both factors contributed to the results found in this study. Further investigation would be needed to determine the extent to which library type and monograph-to-user ratio influenced monograph use. PMID:10783969

  8. Monograph on propagation of sound waves in curved ducts

    Science.gov (United States)

    Rostafinski, Wojciech

    1991-01-01

    After reviewing and evaluating the existing material on sound propagation in curved ducts without flow, it seems strange that, except for Lord Rayleigh in 1878, no book on acoustics has treated the case of wave motion in bends. This monograph reviews the available analytical and experimental material, nearly 30 papers published on this subject so far, and concisely summarizes what has been learned about the motion of sound in hard-wall and acoustically lined cylindrical bends.

  9. Circulation of core collection monographs in an academic medical library.

    Science.gov (United States)

    Schmidt, C M; Eckerman, N L

    2001-04-01

    Academic medical librarians responsible for monograph acquisition face a challenging task. From the plethora of medical monographs published each year, academic medical librarians must select those most useful to their patrons. Unfortunately, none of the selection tools available to medical librarians are specifically intended to assist academic librarians with medical monograph selection. The few short core collection lists that are available are intended for use in the small hospital or internal medicine department library. As these are the only selection tools available, however, many academic medical librarians spend considerable time reviewing these collection lists and place heavy emphasis on the acquisition of listed books. The study reported here was initiated to determine whether the circulation of listed books in an academic library justified the emphasis placed on the acquisition of these books. Circulation statistics for "listed" and "nonlisted" books in the hematology (WH) section of Indiana University School of Medicine's Ruth Lilly Medical Library were studied. The average circulation figures for listed books were nearly two times as high as the corresponding figures for the WH books in general. These data support the policies of those academic medical libraries that place a high priority on collection of listed books.

  10. Experience of a monographic tuberculosis unit: the first 500 cases.

    Science.gov (United States)

    González-Moreno, Juan; García-Gasalla, Mercedes; Cifuentes Luna, Carmen; Mir Villadrich, Isabel; Pareja Bezares, Antonio; Navarro Fernández, Verónica; Serrano Bujalance, Araceli; Pérez Seco, M Cruz; Payeras Cifre, Antonio

    2013-10-01

    Tuberculosis (TB) remains a highly prevalent and potentially severe disease. However, since 2002 the annual incidence has been decreasing both worldwide and in Spain, where the incidence varies widely between regions. The main objective of this study is to describe the experience of a monographic TB unit in a second level hospital. A descriptive study was carried out which included all cases of TB diagnosed in a monographic unit of a secondary hospital between 2003 and 2011. Demographic, clinical, epidemiological and microbiological data were recorded. We analyzed 500 TB cases and found an increasing annual incidence in all subgroups, including native and immigrant populations. Most cases (63.8%) were male, with a median age of 36 years (range 8 months-90 years). In total, 39.8% of patients were foreign born. Coinfection with human immunodeficiency virus was found in 11% of cases. The pulmonary form was most frequently diagnosed (63.8%). Overall mortality was 5.8% with no significant differences between groups (including foreign born and human immunodeficiency virus positive patients). Although TB incidence is globally decreasing, in our study we found an increasing number of cases in recent years in all subgroups, which can be explained by this being a monographic unit with an intensive contact tracing program. Copyright © 2012 SEPAR. Published by Elsevier Espana. All rights reserved.

  11. NTP monograph on health effects of low-level lead.

    Science.gov (United States)

    2012-06-01

    Although reductions in lead (Pb) exposure for the U.S. population have resulted in lower blood Pb levels over time, epidemiological studies continue to provide evidence of health effects at lower and lower blood Pb levels. Low-level Pb was selected for evaluation by the National Toxicology Program (NTP) because of (1) the availability of a large number of epidemiological studies of Pb, (2) a nomination by the National Institute for Occupational Safety and Health for an assessment of Pb at lower levels of exposure, and (3) public concern for effects of Pb in children and adults. This evaluation summarizes the evidence in humans and presents conclusions on health effects in children and adults associated with low-level Pb exposure as indicated by less than 10 micrograms of Pb per deciliter of blood (Monograph on Health Effects of Low-Level Lead. The document and appendices are available at http://ntp.niehs.nih.gov/go/evals. This document provides background on Pb exposure and includes a review of the primary epidemiological literature for evidence that low-level Pb is associated with neurological, immunological, cardiovascular, renal, and/or reproductive and developmental effects. The NTP Monograph presents specific conclusions for each health effect area. Overall, the NTP concludes that there is sufficient evidence that blood Pb levels Monograph on November 17-18, 2011 (http://ntp.niehs.nih.gov/go/37090.

  12. Monograph of Keçiören Municipality

    Directory of Open Access Journals (Sweden)

    Savaş Zafer Şahin

    2015-12-01

    Full Text Available In Turkey, urban administration can be defined from a judicial perspective as the bundle of powers vested in municipalities. It is known that throughout republican history, municipalities, using these powers, have differentiated themselves via their own internal dynamics in parallel to the evolution of public policy and changes in legislation. Yet, it is obvious that there are important gaps in understanding this differentiation taking into consideration the structural conditions of individual municipalities. In particular, in order to thoroughly understand municipalities, it is important to consider periodical pictures of how each municipality has been affected by waves of decentralization and centralization experienced over the last thirty years. In this respect, this monograph, using the same monographic approach developed for the Çankaya Municipality, provides a picture of the existing situation of Ankara’s Keçiören Municipality and presents related problems and potential. This monograph, based on qualitative and quantitative research, presents a holistic evaluation of Keçiören Municipality in terms of its external environment, provision of services, decision-making processes, use of technology and communications.

  13. Arrangement and processing of monographic publications in youth sections of public libraries

    Directory of Open Access Journals (Sweden)

    Mateja Ločniškar-Fidler

    2006-01-01

    Full Text Available A systematic and transparent layout of library material on book shelves of public libraries is one of the essential conditions for successful viewing and searching of materials. The research tried to determine the contemporary classification system of library material for the youth. The data needed for the research was gathered and analyzed by a questionnaire completed by five randomly selected central public libraries. Special collections, arrangement and classification of certain fiction and specialized monographic publications for infants, teenagers and adolescents were analyzed. It was of our interest to observe whether the libraries assign the elements of a call number - which are evident on the library material and in online catalogs – according to standards and current instructions. The article also focuses on the unity and differences of the technical processing, and on color and/or image of labels which additionally explain the classification and the contents of the monographic publications for the youth.

  14. Higher Education in the Republic of Moldova. Monographs on Higher Education.

    Science.gov (United States)

    Tiron, Stefan; Arion, Valentin; Paiu, Mihai; Scalini, Vitalie; Stan, Victor

    This monograph parallels others in the "Monographs" series, allowing easy comparisons among the higher education systems of Europe. The volume describes the development of the higher education system in the Republic of Moldava and analyzes its legislative framework and administrative structures. It outlines steps on the academic career ladder and…

  15. J. W. Gitt: The Cold War's "Voice in the Wilderness." Journalism Monographs Number Ninety-One.

    Science.gov (United States)

    Hamilton, Mary Allienne

    This journalism monograph deals with Josiah W. Gitt and his newspaper, "The Gazette and Daily," which existed from 1915 to 1970 and was referred to as "the voice in the wilderness" because of its stand on controversial issues. The monograph discusses the "Gazette and Daily," its views, Gitt's employees, the…

  16. The Caribbean News Agency: Third World Model. Journalism Monographs Number 71.

    Science.gov (United States)

    Cuthbert, Marlene

    This monograph is a history of the Caribbean News Agency (CANA), which is jointly owned by private and public mass media of its region and independent of both governments and foreign news agencies. It is proposed that CANA may provide a unique model of an independent, regional third-world news agency. Sections of the monograph examine (1) CANA's…

  17. Use of High Throughput Screening Data in IARC Monograph Evaluations (SOT)

    Science.gov (United States)

    Purpose: Evaluation of carcinogenic mechanisms serves a critical role in IARC monograph evaluations, and can lead to “upgrade” or “downgrade” of the carcinogenicity conclusions based on human and animal evidence alone. Three recent IARC monograph Working Groups (110, 112, and 11...

  18. 76 FR 61704 - Availability of Draft NTP Monograph on the Health Effects of Low-Level Lead; Request for Comments...

    Science.gov (United States)

    2011-10-05

    ... HUMAN SERVICES Availability of Draft NTP Monograph on the Health Effects of Low- Level Lead; Request for Comments; Announcement of a Panel Meeting to Peer Review Draft Monograph AGENCY: Division of the National... of Health. ACTION: Availability of Draft NTP Monograph; Request for Comments; Announcement of a Peer...

  19. 76 FR 55391 - Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental Effects of...

    Science.gov (United States)

    2011-09-07

    ... HUMAN SERVICES Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy During Pregnancy and Panel Meeting To Peer Review Draft Monograph AGENCY... (NIEHS), National Institutes of Health. ACTION: Notice of postponement of draft NTP monograph and peer...

  20. 78 FR 67371 - Draft Report on Carcinogens Monographs for ortho-Toluidine and Pentachlorophenol and By-products...

    Science.gov (United States)

    2013-11-12

    ... HUMAN SERVICES National Institutes of Health Draft Report on Carcinogens Monographs for ortho-Toluidine... Report on Carcinogens (RoC) Monographs for ortho-Toluidine and Pentachlorophenol and By-products of its... a.m. until adjournment, approximately 11:30 a.m. Document Availability: Draft monographs...

  1. 78 FR 51733 - Draft Report on Carcinogens Monographs for ortho-Toluidine and Pentachlorophenol and By-Products...

    Science.gov (United States)

    2013-08-21

    ... HUMAN SERVICES National Institutes of Health Draft Report on Carcinogens Monographs for ortho-Toluidine... Carcinogens (RoC) Monographs for ortho-Toluidine and Pentachlorophenol and By-products of its Synthesis.... Document Availability: Draft monographs will be available by August 28, 2013, at...

  2. [The HMPC monograph on Hypericum: Background, development, contents].

    Science.gov (United States)

    Länger, Reinhard

    2010-12-01

    The adoption of the EU community monograph on Hypericum constitutes a milestone in the process of harmonisation of herbal medicinal products within the European Community. The assessment of the published clinical data revealed that for two types of extracts the evidence of the efficacy in mild to moderate depressive episodes compared to placebo or standard medication was found to be acceptable. Additionally, a sufficient efficacy in relapse prophylaxis could be demonstrated for these two herbal preparations. For some other dry extracts, the efficacy in the short-term treatment of symptoms in mild depressive disorders was found to be substantiated. Short-term treatment with preparations containing low amounts of hyperforin did not increase cytochrome P450 enzyme activity. Therefore the oral administration of traditional herbal preparations is restricted to two weeks. In the case that an applicant demonstrates that the daily intake of hyperforin is below 1 mg the warnings on interactions may be omitted in traditional herbal medicinal products. Additionally the cutaneous administration of traditional liquid herbal preparations for the traditional use in symptomatic treatment of minor inflammations of the skin and as an aid in healing minor wounds was included in the monograph.

  3. Revisiting an open access monograph experiment: measuring citations and tweets 5 years later.

    Science.gov (United States)

    Snijder, Ronald

    2016-01-01

    An experiment run in 2009 could not assess whether making monographs available in open access enhanced scholarly impact. This paper revisits the experiment, drawing on additional citation data and tweets. It attempts to answer the following research question: does open access have a positive influence on the number of citations and tweets a monograph receives, taking into account the influence of scholarly field and language? The correlation between monograph citations and tweets is also investigated. The number of citations and tweets measured in 2014 reveal a slight open access advantage, but the influence of language or subject should also be taken into account. However, Twitter usage and citation behaviour hardly overlap.

  4. Automatic identification and normalization of dosage forms in drug monographs

    Directory of Open Access Journals (Sweden)

    Li Jiao

    2012-02-01

    Full Text Available Abstract Background Each day, millions of health consumers seek drug-related information on the Web. Despite some efforts in linking related resources, drug information is largely scattered in a wide variety of websites of different quality and credibility. Methods As a step toward providing users with integrated access to multiple trustworthy drug resources, we aim to develop a method capable of identifying drug's dosage form information in addition to drug name recognition. We developed rules and patterns for identifying dosage forms from different sections of full-text drug monographs, and subsequently normalized them to standardized RxNorm dosage forms. Results Our method represents a significant improvement compared with a baseline lookup approach, achieving overall macro-averaged Precision of 80%, Recall of 98%, and F-Measure of 85%. Conclusions We successfully developed an automatic approach for drug dosage form identification, which is critical for building links between different drug-related resources.

  5. Acacia mangium: Growing and utilization. MPTS monograph series No. 3

    Energy Technology Data Exchange (ETDEWEB)

    Awang, K.; Taylor, D.

    1993-01-01

    With deforestation in the Asia-Pacific region progressing at the rate of 4.4 million ha per year, many countries have adopted plantation forestry using fast-growing species as a way to sustain the commercial supply of tree products and reduce pressure on natural forests. Acacia mangium (A. mangium) is playing a large role in this development, especially in Indonesia and Malaysia, due to its versatility and its ability to recapture grasslands dominated by the noxious weed, Imperata cylindrica. This monograph consolidates information on A. mangium from published literature, unpublished reports and studies, and observations from those familiar with the species. Priorities for future research are included in each chapter and in the final summary.

  6. I. Sleep and development: introduction to the monograph.

    Science.gov (United States)

    El-Sheikh, Mona; Sadeh, Avi

    2015-03-01

    Literature on sleep and child development is growing rapidly in exciting new directions across several disciplines and with this comes a need for guiding conceptual principles and methodological tools. In this introductory chapter, the importance of sleep for child development across multiple domains is highlighted. The aims of this monograph are presented and pertain to the need to consider and integrate theory and research across multiple disciplines and use state-of-the-art methodologies. A developmental ecological systems perspective adapted to sleep illustrates the multiple levels of influence and their importance in the study of child sleep and development. A focal aim is to provide examples of longitudinal studies linking sleep with child development, which are presented in seven chapters of this volume. © 2015 The Society for Research in Child Development, Inc.

  7. The Pharmacokinetics of Second-Generation Long-Acting Injectable Antipsychotics: Limitations of Monograph Values.

    Science.gov (United States)

    Lee, Lik Hang N; Choi, Charles; Collier, Abby C; Barr, Alasdair M; Honer, William G; Procyshyn, Ric M

    2015-12-01

    Product monographs (also known by terms such as Summary of Product Characteristics and Highlights of Prescribing Information, depending on the jurisdiction) provide essential information to ensure the safe and effective use of a drug. Medical practitioners often rely on these monographs for guidance on matters related to pharmacokinetics as well as indications, contraindications, clinical pharmacology, and adverse reactions. The clinical and scientific information found within these documents, forming the basis for decision making, are presumed to be derived from well-designed studies. The objective of this review is to examine the source and validity of the pharmacokinetic data used in establishing the half-lives and times to steady-state reported in the product monographs of second-generation long-acting injectable antipsychotics. Thus, we have critically evaluated the clinical trials from which the pharmacokinetic parameters listed in the product monographs were determined. In many cases, the pharmacokinetic information presented in product monographs is of limited use to clinicians wishing to optimize the effectiveness and tolerability of second-generation long-acting injectable antipsychotics. Under such circumstances, off-label prescribing practices may actually produce better clinical outcomes than if decisions were made based on the product monographs alone.

  8. A Comprehensive List of Items to be Included on a Pediatric Drug Monograph.

    Science.gov (United States)

    Kelly, Lauren E; Ito, Shinya; Woods, David; Nunn, Anthony J; Taketomo, Carol; de Hoog, Matthijs; Offringa, Martin

    2017-01-01

    Children require special considerations for drug prescribing. Drug information summarized in a formulary containing drug monographs is essential for safe and effective prescribing. Currently, little is known about the information needs of those who prescribe and administer medicines to children. Our primary objective was to identify a list of important and relevant items to be included in a pediatric drug monograph. Following the establishment of an expert steering committee and an environmental scan of adult and pediatric formulary monograph items, 46 participants from 25 countries were invited to complete a 2-round Delphi survey. Questions regarding source of prescribing information and importance of items were recorded. An international consensus meeting to vote on and finalize the items list with the steering committee followed. Pediatric formularies are most commonly the first resource consulted for information on medication used in children by 31 Delphi participants. After the Delphi rounds, 116 items were identified to be included in a comprehensive pediatric drug monograph, including general information, adverse drug reactions, dosages, precautions, drug-drug interactions, formulation, and drug properties. Health care providers identified 116 monograph items as important for prescribing medicines for children by an international consensus-based process. This information will assist in setting standards for the creation of new pediatric drug monographs for international application and for those involved in pediatric formulary development.

  9. Three Evidence Based Methods to Compensate for a Lack of Subject Background when Ordering Chemistry Monographs

    Directory of Open Access Journals (Sweden)

    Robert A. Wright

    2008-09-01

    Full Text Available Objective – The aim of this article is to present evidence based methods for the selection of chemistry monographs, particularly for librarians lacking a background in chemistry. These methods will be described in detail, their practical application illustrated, and their efficacy tested by analyzing circulation data.Methods – Two hundred and ninety-five chemistry monographs were selected between 2005 and 2007 using rigorously-applied evidence based methods involving the Library's integrated library system (ILS, Google, and SciFinder Scholar. The average circulation rate of this group of monographs was compared to the average circulation rate of 254 chemistry monographs selected between 2002 and 2004 when the methods were not used or were in an incomplete state of development.Results – Circulations/month were on average 9% greater in the cohort of monographs selected with the rigorously-applied evidence based methods. Further statistical analysis, however, finds that this result can not be attributed to the different application of these methods. Conclusion – The methods discussed in this article appear to provide an evidence base for the selection of chemistry monographs, but their application does not change circulation rates in a statistically significant way. Further research is needed to determine if this lack of statistical significance is real or a product of the organic development and application of these methods over time, making definitive comparisons difficult.

  10. NTP-CERHR monograph on Soy Infant Formula.

    Science.gov (United States)

    2010-09-01

    Soy infant formula contains soy protein isolates and is fed to infants as a supplement to or replacement for human milk or cow milk. Soy protein isolates contains estrogenic isoflavones ("phytoestrogens") that occur naturally in some legumes, especially soybeans. Phytoestrogens are non-steroidal, estrogenic compounds. In plants, nearly all phytoestrogens are bound to sugar molecules and these phytoestrogen-sugar complexes are not generally considered hormonally active. Phytoestrogens are found in many food products in addition to soy infant formula, especially soy-based foods such as tofu, soy milk, and in some over-the-counter dietary supplements. Soy infant formula was selected for evaluation by the National Toxicology Program (NTP) because of the: (1)availability of large number of developmental toxicity studies in laboratory animals exposed to the isoflavones found in soy infant formula (namely, genistein) or other soy products, as well as a number of studies on human infants fed soy infant formula, (2)the availability of information on exposures in infants fed soy infant formula, and (3)public concern for effects on infant or child development. The NTP evaluation was conducted through its Center for the Evaluation of Risks to Human Reproduction (CERHR) and completed in September 2010. The results of this soy infant formula evaluation are published in an NTP Monograph. This document contains the NTP Brief on Soy Infant Formula, which presents NTP's opinion on the potential for exposure to soy infant formula to cause adverse developmental effects in humans. The NTP Monograph also contains an expert panel report prepared to assist the NTP in reaching conclusions on soy infant formula. The NTP concluded there is minimal concern for adverse effects on development in infants who consume soy infant formula. This level of concern represents a "2" on the five-level scale of concern used by the NTP that ranges from negligible concern ("1") to serious concern ("5"). This

  11. The UNO Aviation Monograph Series: The Airline Quality Rating 1998

    Science.gov (United States)

    Bowen, Brent D.; Headley, Dean E.

    1998-01-01

    The Airline Quality Rating (AQR) was developed and first announced in early 1991 as an objective method of comparing airline performance on combined multiple factors important to consumers. Development history and calculation details for the AQR rating system are detailed in The Airline Quality Rating 1991 issued in April, 1991, by the National Institute for Aviation Research at Wichita State University. This current report, Airline Quality Rating 1998, contains monthly Airline Quality Rating scores for 1997. Additional copies are available by contacting Wichita State University or University of Nebraska at Omaha. The Airline Quality Rating 1998 is a summary of month-by-month quality ratings for the ten major U.S. airlines operating during 1997. Using the Airline Quality Rating system and monthly performance data for each airline for the calendar year of 1997, individual and comparative ratings are reported. This research monograph contains a brief summary of the AQR methodology, detailed data and charts that track comparative quality for major airlines domestic operations for the 12 month period of 1997, and industry average results. Also, comparative Airline Quality Rating data for 1991 through 1996 are included to provide a longer term view of quality in the industry.

  12. The UNO Aviation Monograph Series: The Airline Quality Rating 1997

    Science.gov (United States)

    Bowen, Brent D.; Headley, Dean E.

    1997-01-01

    The Airline Quality Rating (AQR) was developed and first announced in early 1991 as an objective method of comparing airline performance on combined multiple factors important to consumers. Development history and calculation details for the AQR rating system are detailed in The Airline Quality Rating 1991 issued in April, 1991, by the National Institute for Aviation Research at Wichita State University. This current report, Airline Rating 1997, contains monthly Airline Quality Rating scores for 1996. Additional copies are available by contacting Wichita State University or the University of Nebraska at Omaha. The Airline Quality Rating (AQR) 1997 is a summary of a month-by-month quality ratings for the nine major domestic U.S. airlines operating during 1996. Using the Airline Quality Rating system and monthly performance data for each airline for the calendar year of 1996, individual and comparative ratings are reported. This research monograph contains a brief summary of the AQR methodology, detailed data and charts that track comparative quality for major domestic airlines across the 12 month period of 1996, and industry average results. Also comparative Airline Quality Rating data for 1991 through 1995 are included to provide a longer term view of quality in the industry.

  13. Comparing Linear Relationships between E-Book Usage and University Student and Faculty Populations: The Differences between E-Reference and E-Monograph Collections

    Science.gov (United States)

    Lamothe, Alain R.

    2013-01-01

    This paper reports the results from a quantitative study examining the strength of linear relationships between Laurentian University students and faculty members and the J. N. Desmarais Library's reference and monograph e-book collections. The number of full-text items accessed, searches performed, and undergraduate, graduate, and faculty…

  14. The Law of Procedure in Student Suspensions and Expulsions. NOLPE Monograph Series. ERIC/CEM State-of-the-Knowledge Series, Number Thirty-four.

    Science.gov (United States)

    Phay, Robert E.

    This state-of-the-knowledge paper, a companion to the author's 1975 monograph on a similar topic, examines the legal ramifications of student suspension, expulsion, and search and seizure of students' property. The author reviews relevant court litigation and state laws pertaining to specific rules on student conduct, the procedures to follow in…

  15. School Administrators and the Courts: A Review of Recent Decisions. ERS Monograph. Series, No. 3. ERIC/CEM State-of-the-Knowledge Series, No. 30.

    Science.gov (United States)

    Hudgins, H. C., Jr.

    This monograph is a review of selected judicial decisions reported by state and federal courts during the past two years and related directly to the administration of elementary or secondary schools. The decisions were identified through a standard search of legal resources at the Temple University Law Library; each decision was read in its…

  16. Comparing Linear Relationships between E-Book Usage and University Student and Faculty Populations: The Differences between E-Reference and E-Monograph Collections

    Science.gov (United States)

    Lamothe, Alain R.

    2013-01-01

    This paper reports the results from a quantitative study examining the strength of linear relationships between Laurentian University students and faculty members and the J. N. Desmarais Library's reference and monograph e-book collections. The number of full-text items accessed, searches performed, and undergraduate, graduate, and faculty…

  17. Preface to the first monograph: The Fourth Psychiatric Revolution

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2004-05-01

    the one hand, and cautious forays in the neurosciences, adoption and genetic studies on the other ( from where, hopefully, significant leads in understanding the aetiology of major psychiatric disorders must arise. Diagnostic refinement is a necessary step in this direction, as is use of sophisticated technology to aid the process.And yet, we know that psychiatry, its practitioners, and its patients, do not function in a vacuum. They interact with, and are influenced by, a wide range of complex, interlinked, social and interpersonal forces.These forces are often generated by people not directly connected with the medical speciality of psychiatry. They are the policy-planners, governments, political leaders, activists, social thinkers, NGOs, mass media, enlightened public opinion etc. They have marked influence on social thought and action, policy, funding and research. They influence people and societies often in more significant ways than the medical speciality of psychiatry considers healthy for society.We may continue to function in a vacuum and wait for wisdom to dawn. Or, we may establish a dialogue with them and work for wisdom for happen.The second option seems the more productive one.No doubt, there are some psychiatrists comfortable with the biological label. There are others comfortable with the social one. Both these are needed, for they help to further robust enquiry in their respective fields. But what we also probably need is an integration, a synthesis of the mass of evidence that these two fields have produced. The inevitable conclusions drawn at our present state of knowledge based on such integration will give rise to pointers for further research as well as guidelines for policy-planners. Moreover, it will result in an awakened public opinion empowered with knowledge and evidence, its actions enlightened, and unlikely to be swayed or manipulated by unscrupulous forces.The Mens Sana Monographs are meant to further attempts at such a Fourth

  18. Writing about Class and Race Differences and Similarities in Early Childhood Mathematics: The Case of One Monograph

    Science.gov (United States)

    Parks, Amy Noelle

    2015-01-01

    This article reports on a literature review of 49 articles that cited a single monograph East Lansing written in 1981 about early learning in mathematics to make claims of similarity or difference across lines of race and class in early mathematics. The review found that while about two-thirds of the articles cited the monograph to make claims of…

  19. Writing about Class and Race Differences and Similarities in Early Childhood Mathematics: The Case of One Monograph

    Science.gov (United States)

    Parks, Amy Noelle

    2015-01-01

    This article reports on a literature review of 49 articles that cited a single monograph East Lansing written in 1981 about early learning in mathematics to make claims of similarity or difference across lines of race and class in early mathematics. The review found that while about two-thirds of the articles cited the monograph to make claims of…

  20. Access to Basic Education in Ghana: Politics, Policies and Progress. CREATE Pathways to Access. Research Monograph No. 42

    Science.gov (United States)

    Little, Angela W.

    2010-01-01

    This monograph examines the history and politics of educational reform in Ghana. Using data from interviews conducted with senior policy-makers, implementers and researchers, as well as documentary sources, to explore the drivers and inhibitors of change at the political, bureaucratic and grass-roots levels. The monograph explores the nature of…

  1. A monograph assignment as an integrative application of evidence-based medicine and pharmacoeconomic principles.

    Science.gov (United States)

    Law, Anandi V; Jackevicius, Cynthia A; Bounthavong, Mark

    2011-02-10

    To describe the development and assessment of monographs as an assignment to incorporate evidence-based medicine (EBM) and pharmacoeconomic principles into a third-year pharmacoeconomic course. Eight newly FDA-approved drugs were assigned to 16 teams of students, where each drug was assigned to 2 teams. Teams had to research their drug, write a professional monograph, deliver an oral presentation, and answer questions posed by faculty judges. One team was asked to present evidence for inclusion of the drug into a formulary, while another team presented evidence against inclusion. The teams' average score on the written report was 99.1%; on the oral presentation, 92.5%, and on the online quiz given at the end of the presentations, 77%. Monographs are a successful method of incorporating and integrating learning across different concepts, as well as increasing relevance of pharmacoeconomics in the PharmD curriculum.

  2. ŞTEFANIA CRISTESCU AND THE „MONOGRAPHIC RESEARCH CRISIS”, 1932–1934

    Directory of Open Access Journals (Sweden)

    Professor ZOLTÁN ROSTÁS

    2013-05-01

    Full Text Available This article analyzes the crisis of the monographic research undertaken by the Sociological School from Bucharest (led by Professor Dimitrie Gusti, between 1932–1933. The focus is on the particular perspective offered by one salient member of the group, Ştefania Cristescu-Golopenţia. The internal reason of the “monograph crisis” was the change in status and orientation of the young members of the School, a transformation that – at least in the case of Şt. C.-G. – disturbed her research work, but did not prevent her from carrying out outstanding studies

  3. Harmonization of monographic standards is needed to ensure the quality of Chinese medicinal materials

    Directory of Open Access Journals (Sweden)

    Zhao Sandy

    2009-09-01

    Full Text Available Abstract This article provides an overview on the regulations of Chinese medicinal materials (CMMs in various countries and regions. Harmonization of CMM monographs would provide standards for the quality control of CMM products and play an important role in the modernization and globalization of Chinese medicine. A harmonized regulatory system would improve the quality of CMMs thereby ensuring the safety of the products and assisting Chinese medicine practitioners in their practice. The fast growing demand worldwide for traditional medicines calls for harmonized monographic standards to safeguard the safety and quality of CMM products.

  4. Working toward a Continuum of Professional Learning Experiences for Teachers of Science and Mathematics. Research Monograph.

    Science.gov (United States)

    Mundry, Susan; Spector, Barbara; Stiles, Katherine; Loucks-Horsley, Susan

    This monograph is the result of a one-year qualitative study conducted by the National Institute for Science Education (NISE) of reform-oriented interventions, structures, and relationships in preservice and inservice education of teachers of science and mathematics. The study investigated 61 initiatives of reform activity involving teachers of…

  5. A monograph of the African Squirrels, with an enumeration of the specimens in the Leyden Museum

    NARCIS (Netherlands)

    Jentink, F.A.

    1882-01-01

    The African Squirrels have never been monographically studied, although a large number of more or less important descriptions of different species have been given, which are to be found in different periodicals. The late Temminck in his »Esquisses zoologiques sur la côte de Guiné. 1853” was the firs

  6. Herbert L. Matthews and the Cuban Story. Journalism Monographs No. 54.

    Science.gov (United States)

    Knudson, Jerry W.

    Herbert L. Matthews, a veteran journalist for the "New York Times," traveled to Cuba in 1957 to interview Fidel Castro, then a revolutionary seeking the overthrow of the Batista regime. This monograph considers the impact of Matthews' newspaper articles about those interviews and of his subsequent articles about the Cuban situation and…

  7. Procedures for Inventorying and Replacing Missing Monographs in a Large Research Library.

    Science.gov (United States)

    Shaughnessy, Thomas W.

    Divided into inventory project procedures for the identification of missing books for future replacement and inventory guidelines for use by subject librarians to determine whether an item should be replaced, this report sets forth very specific procedures for conducting a comprehensive inventory of monographic holdings. They are based on…

  8. Nutritional Problems and Policy in Tanzania. Cornell International Nutrition Monograph Series, Number 7 (1980).

    Science.gov (United States)

    Mgaza, Olyvia

    This monograph discusses policies designed to deal with food and nutrition problems in Tanzania. Available information on food supplies and nutritional conditions in Tanzania clearly shows that the country faces nutritional problems; protein energy malnutrition is the most serious and requires priority action. Iron deficiency anemia, goiter, and…

  9. Interactive Robotic Aids--One Option for Independent Living: An International Perspective. Monograph Number 37.

    Science.gov (United States)

    Foulds, Richard, Ed.

    The monograph is a collection of papers on the role of robotics in rehabilitation. The first four papers represent contributions from other countries: "Spartacus and Manus: Telethesis Developments in France and the Netherlands" (H. Kwee); "A Potential Application in Early Education and a Possible Role for a Vision System in a Workstation Based…

  10. The Taming of the Press in Sri Lanka. Journalism Monographs Number 39.

    Science.gov (United States)

    Gunaratne, Shelton A.

    This issue of "Journalism Monographs" deals specifically with the state of newspaper journalism in Sri Lanka, formerly the Dominion of Ceylon. The country's literacy rate is about 81 percent. The first section of this article is a general discussion of newspaper journalism in Sri Lanka, examining historical background and such press…

  11. Logo and Geometry. Journal for Research in Mathematics Education Monograph Series.

    Science.gov (United States)

    Clements, Douglas H.; Battista, Michael T.

    This book, the 10th volume in the Journal for Research in Mathematics Education (JRME) Monograph Series, discusses the geometry curriculum and investigates how elementary school students learn geometric concepts and how Logo programming and its turtle graphics might affect this learning. This volume also provides details on the development,…

  12. The evaluation of scientific monograph and publisher's role: the spanish project Scholarly Publishers Indicators (SPI

    Directory of Open Access Journals (Sweden)

    Andrea Capaccioni

    2016-05-01

    Full Text Available This paper aims to examine the issue about the quality assessment of scientific monograph and the role of publishers in the field of Humanities and Social Sciences, focusing on the Spanish project Scholarly Publishers Indicators (SPI. This project was born to identify and explore specific quality indicators for scientific books, starting from the opinion of SSH Spanish experts.

  13. Administration and Supervision for Safety in Sports. Sports Safety Series: Monograph No. 1.

    Science.gov (United States)

    Borozne, Joseph, Ed.; And Others

    Examined in this monograph are issues concerned with accident problems in sports. Materials are organized under eight headings, each developed by an expert in the area: (1) the injury problem in sports; (2) philosophy of sports accident prevention and injury control; (3) an introduction to administration and supervision; (4) administration and…

  14. Honors Programs at Smaller Colleges. 3rd Edition. National Collegiate Honors Council Monograph Series

    Science.gov (United States)

    Schuman, Samuel

    2011-01-01

    This monograph focuses upon areas of special concern to those working with honors at smaller colleges and universities: mission, recruitment, facilities, administration, budget, and curriculum. In each area, the author makes some general suggestions about overall operating principles, note specific issues that can lead to difficulties, and suggest…

  15. Data Matching, Integration, and Interoperability for a Metric Assessment of Monographs

    DEFF Research Database (Denmark)

    Zuccala, Alesia Ann; Cornacchia, Roberto

    2016-01-01

    This paper details a unique data experiment carried out at the University of Amsterdam, Center for Digital Humanities. Data pertaining to monographs were collected from three autonomous resources, the Scopus Journal Index, WorldCat.org and Goodreads, and linked according to unique identifiers...

  16. Employer Relations and Recruitment Services: An Essential Part of Postsecondary Career Services. Monograph Series

    Science.gov (United States)

    Hoover, Myrna P.; Lenz, Janet G.; Garis, Jeff

    2013-01-01

    This monograph is intended for any career services provider seeking a guide for developing employer relations and recruitment services at a postsecondary institution. It serves to inform readers about the changing meaning of "placement" over the years and the role it currently plays in career services. The publication describes…

  17. HPLC method validation for modernization of the tetracycline hydrochloride capsule USP monograph

    Directory of Open Access Journals (Sweden)

    Emad M. Hussien

    2014-12-01

    Full Text Available This paper is a continuation to our previous work aiming at development and validation of a reversed-phase HPLC for modernization of tetracycline-related USP monographs and the USP general chapter . Previous results showed that the method is accurate and precise for the assay of tetracycline hydrochloride and the limit of 4-epianhydrotetracycline impurity in the drug substance and oral suspension monographs. The aim of the current paper is to examine the feasibility of the method for modernization of USP tetracycline hydrochloride capsule monograph. Specificity, linearity, accuracy and precision were examined for tetracycline hydrochloride assay and 4-epianhydrotetracycline limit. The method was linear in the concentration range from 80% to 160% (r>0.9998 of the assay concentration (0.1 mg/mL for tetracycline hydrochloride and from 50% to 150% (r>0.997 of the acceptance criteria specified in tetracycline hydrochloride capsule monograph for 4-epianhydrotetracycline (NMT 3.0%. The recovery at three concentration levels for tetracycline hydrochloride assay was between 99% and 101% and the RSD from six preparations at the concentration 0.1 mg/mL is less than 0.6%. The recovery for 4-epianhydrotetracycline limit procedure over the concentration range from 50% to 150% is between 96% and 102% with RSD less than 5%. The results met the specified acceptance criteria.

  18. Place as Text: Approaches to Active Learning. 2nd Edition. National Collegiate Honors Council Monograph Series

    Science.gov (United States)

    Braid, Bernice, Ed.; Long, Ada, Ed.

    2010-01-01

    The decade since publication of "Place as Text: Approaches to Active Learning" has seen an explosion of interest and productivity in the field of experiential education. This monograph presents a story of an experiment and a blueprint of sorts for anyone interested in enriching an existing program or willing to experiment with pedagogy…

  19. Does It Make a Sound: Are Open Access Monographs Discoverable in Library Catalogs?

    Science.gov (United States)

    McCollough, Aaron

    2017-01-01

    This article describes an exploratory study examining the common perception among library-based publishers that open access academic publications (especially monographs) are not readily discoverable in library catalogs. Using titles from the Michigan Publishing imprint, digital culture books, the study provides an empirical basis for evaluating…

  20. Does It Make a Sound: Are Open Access Monographs Discoverable in Library Catalogs?

    Science.gov (United States)

    McCollough, Aaron

    2017-01-01

    This article describes an exploratory study examining the common perception among library-based publishers that open access academic publications (especially monographs) are not readily discoverable in library catalogs. Using titles from the Michigan Publishing imprint, digital culture books, the study provides an empirical basis for evaluating…

  1. Cocaine: Pharmacology, Effects, and Treatment of Abuse. National Institute on Drug Abuse Research Monograph 50.

    Science.gov (United States)

    Grabowski, John, Ed.

    This monograph consists of eight papers which refer in one way or another to the pharmacology of cocaine. The papers are: (1) Cocaine 1984: Introduction and Overview" (John Grabowski); (2) "Cocaine: A Growing Public Health Problem" (Edgar H. Adams and Jack Durell); (3) "Neural Mechanisms of the Reinforcing Action of…

  2. Interwoven Lives: Adolescent Mothers and Their Children. Research Monographs in Adolescence.

    Science.gov (United States)

    Whitman, Thomas L.; Borkowski, John G.; Keogh, Deborah A.; Weed, Keri

    This monograph details the Notre Dame Parenting Project, a comprehensive longitudinal study of the lives of adolescent mothers and their children from pregnancy through the first 8 years of life, describing how their respective developmental trajectories are interwoven and linked to the social contexts in which they live. A total of 281…

  3. Education of the Handicapped and Its Implications for Elementary Industrial Arts. ACESIA Monograph 7.

    Science.gov (United States)

    Calder, Clarence R., Jr.; Horvath, Lester J.

    The purpose of this monograph is to illustrate the implications of Public Law 94-142 on public education at the state and local levels. The first section illustrates the importance for all educators to be aware of the administrative design used in this piece of permanent legislation. The second section describes the major provisions of Public Law…

  4. On the rise of Bayesian econometrics after Cowles Foundation monographs 10, 14

    NARCIS (Netherlands)

    Baştürk, N.; Çakmaklı, C.; Ceyhan, S.P.; van Dijk, H.K.

    2014-01-01

    This paper starts with a brief description of the introduction of the likelihood approach in econometrics as presented in Cowles Foundation Monographs 10 and 14. A sketch is given of the criticisms on this approach mainly from the first group of Bayesian econometricians. Publication and citation pat

  5. On the rise of Bayesian econometrics after Cowles Foundation Monographs 10, 14

    NARCIS (Netherlands)

    Baştürk, N.; Çakmak, C.; Pinar Ceyhan, S.; van Dijk, H.K.

    2014-01-01

    This paper starts with a brief description of the introduction of the likelihood approach in econometrics as presented in Cowles Foundation Monographs 10 and 14. A sketch is given of the criticisms on this approach mainly from the first group of Bayesian econometricians. Publication and citation pat

  6. The Self Perception of Male and Female Homosexuals. Criminal Justice Monograph: Vol. 6, No. 3.

    Science.gov (United States)

    Sisson, William Henry, III

    This monograph presents a historical and theoretical review of homosexuality followed by a study of the self-perception of homosexuals. History bears out that homosexuality has always been one aspect of human sexuality and was more prominent in other periods of human history, depending on societal attitudes and mores. At present, many authors…

  7. Recent Advances in Nutrition Education. The Health Education Monograph Series. Volume 15 Number 3.

    Science.gov (United States)

    Shier, Nathan W., Ed.; Torabi, Mohammad R., Ed.

    This monograph presents a collection of articles on nutrition education: "Using the DINE Score To Improve Food Choice Behavior" (Darwin Dennison and Kathryn F. Dennison); "Self-Reported Food Intake Patterns of Older Adults in Australia, China, and the United States" (Alyce D. Fly, Nathan W Shier, Barbara A. Hawkins, Susan J.…

  8. Employer Relations and Recruitment Services: An Essential Part of Postsecondary Career Services. Monograph Series

    Science.gov (United States)

    Hoover, Myrna P.; Lenz, Janet G.; Garis, Jeff

    2013-01-01

    This monograph is intended for any career services provider seeking a guide for developing employer relations and recruitment services at a postsecondary institution. It serves to inform readers about the changing meaning of "placement" over the years and the role it currently plays in career services. The publication describes…

  9. Making Industrial Education Facilities Accessible to the Physically Disabled. A Professional Monograph.

    Science.gov (United States)

    Shackelford, Ray; Henak, Richard

    This monograph focuses on the design of accessible industrial education facilities for individuals with physical disabilities. In chapter 1 accessibility is defined, and three significant pieces of federal legislation regarding the equality of educational opportunities for special needs populations are discussed. The role of industrial education…

  10. South Asian Nomads--A Literature Review. CREATE Pathways to Access. Research Monograph No. 58

    Science.gov (United States)

    Sharma, Anita

    2011-01-01

    This review of literature on South Asian nomads is part of a series of monographs on educational access published by the Consortium for Research on Educational Access Transitions and Equity (CREATE). In the context of India, most recent work has focused on access to the education system for the poor. CREATE research in India has focused on …

  11. The Aeronautics Education, Research, and Industry Alliance (AERIAL) 2002 Report. UNO Aviation Monograph Series. UNOAI Report.

    Science.gov (United States)

    Bowen, Brent D.; Box, Richard C.; Fink, Mary M.; Gogos, George; Lehrer, Henry R.; Narayanan, Ram M.; Nickerson, Jocelyn S.; O'Neil, Patrick D.; Tarry, Scott E.; Vlasek, Karisa D.

    This document contains four papers on aeronautics education, research, and partnerships that partly supported through the Aeronautics Education, Research, and Industry Alliance (AERIAL). The paper "2002 AERIAL Monograph" (Brent D. Bowen, Jocelyn S. Nickerson, Mary M. Fink, et al.) presents an overview of research and development in the…

  12. Cuento Therapy. Folktales as a Culturally Sensitive Psychotherapy for Puerto Rican Children. Monograph No. 12.

    Science.gov (United States)

    Constantino, Giuseppe; And Others

    A seven-year project developing and testing cuento therapy, a form of child psychotherapy in which Puerto Rican mothers recount to their children folktales taken from Puerto Rican culture, is described and evaluated in this monograph. Chapter 1 explains how the research presented in later chapters fits into substantially broader patterns of…

  13. News Piracy: Unfair Competition and the Misappropriation Doctrine. Journalism Monographs No. 56.

    Science.gov (United States)

    Sullivan, Paul W.

    Unfair competition is a complex problem affecting all areas of American business, including the communications media. Piracy of material, an alarmingly widespread example of unfair competition, involves legal as well as ethical questions. This monograph uses the historical approach to trace the development of common-law precedent and trends and…

  14. The Evaluation and Selection of Instructional Software for Use with the Learning Disabled. CREATE Monograph Series.

    Science.gov (United States)

    Weisgerber, Robert A.; Blake, Patricia L.

    Fourth in a series of six monographs on the use of new technologies in the instruction of learning disabled (LD) students, this paper explores issues related to the evaluation and selection of instructional software for LD students. Topics discussed include the following: (1) criteria for instructionally useful software (e.g., flexibility and…

  15. The Learning Disabled and Computer Based Education: Program Design Strategies. CREATE Monograph Series.

    Science.gov (United States)

    Rubin, David; And Others

    Third in a series of six monographs on the use of new technologies in the instruction of learning disabled students, the paper explores program design strategies for computer-based instructional materials. Section 1 summarizes ideas related to models of perception and cognition, theories of instruction, and key characteristics of intelligent…

  16. Existing and Emerging Technologies in Education: A Descriptive Overview. CREATE Monograph Series.

    Science.gov (United States)

    Bakke, Thomas W.

    Second in a series of six monographs on the use of new technologies in the instruction of learning disabled students, the paper offers a descriptive overview of new technologies. Topics addressed include the following: (1) techniques for sharing computer resources (including aspects of networking, sharing information through databases, and the use…

  17. Optimal Approaches to Microcomputer Implementation in the Schools. [CREATS Monograph Series.

    Science.gov (United States)

    Bakke, Thomas W.

    Fifth in a series of six monographs on the use of new technologies in the instruction of learning disabled students, the paper describes how schools can plan for the acquisition of computer hardware and software, and how they can provide district-level staff training in its use. Discussion focuses on the development of a technology implementation…

  18. Man-made mineral (vitreous) fibres: evaluations of cancer hazards by the IARC Monographs Programme.

    Science.gov (United States)

    Baan, Robert A; Grosse, Yann

    2004-09-03

    Man-made vitreous (glass-like) fibres are non-crystalline, fibrous inorganic substances (silicates) made primarily from rock, slag, glass or other processed minerals. These materials, also called man-made mineral fibres, include glass fibres (used in glass wool and continuous glass filament), rock or stone wool, slag wool and refractory ceramic fibres. They are widely used for thermal and acoustical insulation and to a lesser extent for other purposes. These products are potentially hazardous to human health because they release airborne respirable fibres during their production, use and removal. Man-made mineral fibres and man-made vitreous fibres have been the subject of reviews by IARC Monographs Working Groups in 1987 and 2001, respectively, which resulted in evaluations of the carcinogenic hazard to humans from exposure to these materials. These reviews and evaluations have been published as Volumes 43 and 81 of the IARC Monographs series [IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 43, Man-made Mineral Fibres and Radon (1988); IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 81, Man-made Vitreous Fibres (2002)]. The re-evaluation in 2001 was undertaken because there have been substantial improvements in the quality of the epidemiological information available on the carcinogenicity to humans of glass fibres, continuous glass filament and rock/slag wool. The new evaluations have addressed the limitations of earlier cohort studies, particularly concerning the lack of adjustment with respect to concomitant risk factors such as smoking and other sources of occupational exposure. In addition, the evaluation of the evidence for carcinogenicity of glass fibres to experimental animals has been refined, by making a distinction between insulation glass wool and special-purpose glass fibres. The results of the evaluations in 1987 and 2001 are thus different in several aspects. In this paper, the reviews and evaluations

  19. The Development of Monograph with 3-Dimentional Illustrations Titled “Augmented Chemistry: Hydrocarbon” as Learning Enrichment Materials

    Science.gov (United States)

    Ernawati, D.; Ikhsan, J.

    2017-02-01

    The development of 3D technology provides more advantages in education sectors. In chemistry, the 3D technology makes chemistry objects look more tangible. This research developed a monograph titled “Augmented Chemistry: Hydrocarbon” as learning enrichment materials. The development model consisted of 5 steps, which were the adaptation of the ADDIE model. The 3D objects of chemistry were built using the computer applications of Chem Sketch, and Google Sketch Up with AR Plugin. The 3D objects were displayed by relevant markers on the texts of the monograph from which the visualizations of the 3D objects appeared when they were captured by digital camera of laptop or smartphone, and were possibly viewed with free-rotation. Not only were 3D chemistry objects included in the monograph, but also graphics, videos, audios, and animations, which facilitated more fun learning for readers of the monograph. After the reviews by the experts of subject matter, of media, of instruction, and by peers, the monograph was revised, and then rated by chemistry teachers. The analysis of the data showed that the monograph titled “Augmented Chemistry: Hydrocarbon” was in the criteria of very good for the enrichment materials of Chemistry learning.

  20. Non-European traditional herbal medicines in Europe: a community herbal monograph perspective.

    Science.gov (United States)

    Qu, Liping; Zou, Wenjun; Zhou, Zhenxiang; Zhang, Tingmo; Greef, JanVander; Wang, Mei

    2014-10-28

    The European Directive 2004/24/EC introducing a simplified registration procedure for traditional herbal medicinal products, plays an important role in harmonising the current legislation framework for all herbal medicinal products in the European Union (EU). Although substantial achievements have been made under the new scheme, only a limited number of herbal medicinal products from non-European traditions commonly used in Europe have been registered. Therefore, identification of the obstacles, and determination of appropriate means to overcome the major challenges in the registration of non-European traditional herbal medicinal products are of critical importance for the EU herbal medicinal product market. The primary aims of this study were to understand the key issues and obstacles to registration of non-European traditional herbal medicinal products within the EU. The findings may identify the need for more attention on the Community herbal monographs elaborated by the Herbal Medicinal Products Committee (HMPC), as well as further evidence based scientific research on non-European herbal substances/preparations by the scientific community. A systematic evaluation of the herbal substances and preparations included in Community herbal monographs and public statements has been carried out. The focus was herbal substances and preparations derived from non-European traditions. Of the 109 adopted Community herbal monographs, 10 are herbal substances used in Chinese traditional medicine. Where the HMPC issued a public statement because it was unable to elaborate a monograph more than half-involved herbal substances/preparations from non-European traditions. The main reasons herbal substances/preparations from non-European traditions were not accepted for inclusion in the Community herbal monographs have been identified as due to unfulfilled requirements of Directive 2004/24/EC. The most common reasons were the lack of evidence to demonstrate a 15-year minimum

  1. The UNO Aviation Monograph Series: Aviation Security: An Annotated Bibliography of Responses to the Gore Commission

    Science.gov (United States)

    Carrico, John S.; Schaaf, Michaela M.

    1998-01-01

    This monograph is a companion to UNOAI Monograph 96-2, "The Image of Airport Security: An Annotated Bibliography," compiled in June 1996. The White House Commission on Aviation Safety and Security, headed by Vice President Al Gore, was formed as a result of the TWA Flight 800 crash in August 1996. The Commission's final report included 31 recommendations addressed toward aviation security. The recommendations were cause for security issues to be revisited in the media and by the aviation industry. These developments necessitated the need for an updated bibliography to review the resulting literature. Many of the articles were written in response to the recommendations made by the Gore Commission. "Aviation Security: An Annotated Bibliography of Responses to the Gore Commission" is the result of this need.

  2. Truth, Perception, and Consequences (Proteus Monograph Series, Volume 1, Issue 1, November 2007)

    Science.gov (United States)

    2007-11-01

    TruTh , PercePTion, and consequences The Proteus Monograph Series Volume 1, Issue 1 November 2007 Report Documentation Page Form ApprovedOMB No. 0704...2007 to 00-00-2007 4. TITLE AND SUBTITLE Truth , Perception, and Consequences 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...Intelligence, or the U.S. Government. This report is cleared for public release; distribution is unlimited. TruTh , PercePTion, and consequences by

  3. Elements for a of Rural Research Methodology. Sociological Monographs and the Rural Sociological Atlas

    Directory of Open Access Journals (Sweden)

    VERONICA DUMITRAŞCU

    2009-04-01

    Full Text Available This article attempts to provide an "X-ray image" of rural life through the inventory of certain research methods and techniques used in the study of Romanian rural communities. Sociological monographs, including the sociological rural atlas,were the epitome of Gustian sociology. The investigation of rural life focusing on certain key aspects - economic, political, and religious - simultaneously, can provide a more comprehensive perspective on the Romanian village than would be possible by considering each of these elements on its own. Hence, the monograph brings unity to past and present realities. The dynamic character of sociology, on which the Sociological School of Bucharest focused, can be applied nowadays as well. The sociologist is called forth now more than ever in order to interfere with social life. In this case, the methodological tool, that is the monograph, is very useful. Through the Social Atlas, the problems of rural communities can be anticipated and diagnosed and, as such, certain serious problems which take place in a social dimension can be averted. Hence, the Social Atlas project is very useful for research on rural life, as the maps capture the progress of social change.

  4. Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction.

    Science.gov (United States)

    Basalo, Carlos; Mohn, Tobias; Hamburger, Matthias

    2006-10-01

    The extraction methods in selected monographs of the European and the Swiss Pharmacopoeia were compared to pressurized liquid extraction (PLE) with respect to the yield of constituents to be dosed in the quantitative assay for the respective herbal drugs. The study included five drugs, Belladonnae folium, Colae semen, Boldo folium, Tanaceti herba and Agni casti fructus. They were selected to cover different classes of compounds to be analyzed and different extraction methods to be used according to the monographs. Extraction protocols for PLE were optimized by varying the solvents and number of extraction cycles. In PLE, yields > 97 % of extractable analytes were typically achieved with two extraction cycles. For alkaloid-containing drugs, the addition of ammonia prior to extraction significantly increased the yield and reduced the number of extraction cycles required for exhaustive extraction. PLE was in all cases superior to the extraction protocol of the pharmacopoeia monographs (taken as 100 %), with differences ranging from 108 % in case of parthenolide in Tanaceti herba to 343 % in case of alkaloids in Boldo folium.

  5. Prioritizing Chemicals for Risk Assessment Using Chemoinformatics: Examples from the IARC Monographs on Pesticides.

    Science.gov (United States)

    Guha, Neela; Guyton, Kathryn Z; Loomis, Dana; Barupal, Dinesh Kumar

    2016-12-01

    Identifying cancer hazards is the first step towards cancer prevention. The International Agency for Research on Cancer (IARC) Monographs Programme, which has evaluated nearly 1,000 agents for their carcinogenic potential since 1971, typically selects agents for hazard identification on the basis of public nominations, expert advice, published data on carcinogenicity, and public health importance. Here, we present a novel and complementary strategy for identifying agents for hazard evaluation using chemoinformatics, database integration, and automated text mining. To inform selection among a broad range of pesticides nominated for evaluation, we identified and screened nearly 6,000 relevant chemical structures, after which we systematically compiled information on 980 pesticides, creating network maps that allowed cluster visualization by chemical similarity, pesticide class, and publicly available information concerning cancer epidemiology, cancer bioassays, and carcinogenic mechanisms. For the IARC Monograph meetings that took place in March and June 2015, this approach supported high-priority evaluation of glyphosate, malathion, parathion, tetrachlorvinphos, diazinon, p,p'-dichlorodiphenyltrichloroethane (DDT), lindane, and 2,4-dichlorophenoxyacetic acid (2,4-D). This systematic approach, accounting for chemical similarity and overlaying multiple data sources, can be used by risk assessors as well as by researchers to systematize, inform, and increase efficiency in selecting and prioritizing agents for hazard identification, risk assessment, regulation, or further investigation. This approach could be extended to an array of outcomes and agents, including occupational carcinogens, drugs, and foods. Citation: Guha N, Guyton KZ, Loomis D, Barupal DK. 2016. Prioritizing chemicals for risk assessment using chemoinformatics: examples from the IARC Monographs on Pesticides. Environ Health Perspect 124:1823-1829; http://dx.doi.org/10.1289/EHP186.

  6. Prioritizing Chemicals for Risk Assessment Using Chemoinformatics: Examples from the IARC Monographs on Pesticides

    Science.gov (United States)

    Guha, Neela; Guyton, Kathryn Z.; Loomis, Dana; Barupal, Dinesh Kumar

    2016-01-01

    Background: Identifying cancer hazards is the first step towards cancer prevention. The International Agency for Research on Cancer (IARC) Monographs Programme, which has evaluated nearly 1,000 agents for their carcinogenic potential since 1971, typically selects agents for hazard identification on the basis of public nominations, expert advice, published data on carcinogenicity, and public health importance. Objectives: Here, we present a novel and complementary strategy for identifying agents for hazard evaluation using chemoinformatics, database integration, and automated text mining. Discussion: To inform selection among a broad range of pesticides nominated for evaluation, we identified and screened nearly 6,000 relevant chemical structures, after which we systematically compiled information on 980 pesticides, creating network maps that allowed cluster visualization by chemical similarity, pesticide class, and publicly available information concerning cancer epidemiology, cancer bioassays, and carcinogenic mechanisms. For the IARC Monograph meetings that took place in March and June 2015, this approach supported high-priority evaluation of glyphosate, malathion, parathion, tetrachlorvinphos, diazinon, p,p′-dichlorodiphenyltrichloroethane (DDT), lindane, and 2,4-dichlorophenoxyacetic acid (2,4-D). Conclusions: This systematic approach, accounting for chemical similarity and overlaying multiple data sources, can be used by risk assessors as well as by researchers to systematize, inform, and increase efficiency in selecting and prioritizing agents for hazard identification, risk assessment, regulation, or further investigation. This approach could be extended to an array of outcomes and agents, including occupational carcinogens, drugs, and foods. Citation: Guha N, Guyton KZ, Loomis D, Barupal DK. 2016. Prioritizing chemicals for risk assessment using chemoinformatics: examples from the IARC Monographs on Pesticides. Environ Health Perspect 124:1823–1829;

  7. Le monde du theatre: monographie relative au montage d'une piece de theatre (The World of Theater: Monograph on Mounting a Theatrical Production).

    Science.gov (United States)

    Bokor, Pierre

    This monograph (in French) provides Alberta teachers with information relating to teaching about the world of the theater, and discusses the principal elements to be considered in mounting a theatrical production. It is intended for French language dramatic arts teachers (both in immersion courses and French-speaking schools). The monograph's four…

  8. A Review of the Multi-Authored Monograph “The Medical (Clinical Psychology Diagnosis: Current State and Prospects”

    Directory of Open Access Journals (Sweden)

    Vachkov I.V.

    2017-06-01

    Full Text Available The monograph presents a number of articles written by leading domestic clinical psychologists on various issues connected with psychological diagnosis. The multi-authored monograph was written for the international research-to-practice conference “The medical (clinical psychology diagnosis: tradition and prospects”. The conference took place in Moscow on November 29-30, 2016. The book consists of the following sections: "Research methodology in clinical psychology", “The development of endogenous mental pathology diagnosis current trends”, “The development of clinical psychology diagnostics current trends: age aspects”, “The main problems of clinical-psychological prevention and rehabilitation”. The materials of the monograph may be interesting and useful for scientists, psychology lecturers, students and post-graduate students, as well as for specialists working in the field of public health, education and social support for the population.

  9. NTP Monograph: Developmental Effects and Pregnancy Outcomes Associated With Cancer Chemotherapy Use During Pregnancy.

    Science.gov (United States)

    2013-05-01

    The National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) conducted an evaluation of the developmental effects and pregnancy outcomes associated with cancer chemotherapy use during pregnancy in humans. The final NTP monograph was completed in May 2013 (available at http:// ntp.niehs.nih.gov/go/36495). The incidence of cancer during pregnancy has been reported to occur from 17 to 100 per 100,000 pregnant women. Chemotherapy is a common treatment for cancer; however, most chemotherapy agents are classified as known or suspected human teratogens. Cancer chemotherapy use during pregnancy was selected for evaluation by the NTP because of the: (1) paucity of comprehensive reviews on the pregnancy outcomes following cancer chemotherapy use during pregnancy in humans, including the integration of the developmental animal toxicology literature with the observational studies in humans, and (2) growing public interest in the developmental effects of chemotherapy on offspring exposed to cancer chemotherapy during gestation due to the expected incidence of cancer diagnosed during pregnancy as women delay pregnancy to later ages. Of the approximately 110 cancer chemotherapeutic agents currently in use, the NTP monograph includes data on 56 agents used during 1,261 pregnancies for which pregnancy outcomes were documented. Overall, the NTP evaluation found that treatment with chemotherapy for cancer appeared to be associated with: (1) a higher rate of major malformations following exposure during the first trimester compared to exposure in the second and/or third trimester; (2) an increase the rate of stillbirth following exposure in the second and/ or third trimester; abnormally low levels of amniotic fluid (primarily attributable to Trastuzumab); and (3), also data are insufficient, impaired fetal growth and myelosuppression. Treatment with chemotherapy for cancer during pregnancy did not appear to increase spontaneous preterm birth, or impair

  10. Monograph support provided by the National Library of Medicine and its regional medical libraries in the medical behavioral sciences.

    Science.gov (United States)

    Saye, J D; Griffith, B C

    1988-01-01

    The National Library of Medicine's (NLM) monographic resources in the medical behavioral sciences (MBS) were examined to assess NLM's ability to support the needs of researchers writing in this area. A sample of 239 representative monographs derived from citations in MBS-related articles published in 61 journals in 1981 were evaluated. These monographs were limited to works published between 1978 and 1981, inclusive. The subject distribution of the sample included fourteen of the twenty-one main classes in the LC classification, although BF (psychology), H (social sciences), and R (medicine) constituted 80.3% of the sample. The study revealed that NLM held 48.5% of the sample. The holdings of ten research medical libraries, including six of the seven regional medical libraries, were also evaluated in order to gauge NLM's ability to support that element of the medical library network. The holding rates of these libraries ranged widely (9.6% to 36%), although NLM was found to have far more extensive holdings overall, and when assessed against classes BF, H, and R. Overall, NLM could have supplied from 28.8% to 44.5% of the monographs not held by the medical libraries. In only a few cases were the ten medical libraries able to provide access to monographs not held by NLM. The findings of the study indicate that, regardless of NLM's indication of support to the MBS area, the holdings of more general research and academic libraries are essential to support the monograph needs of MBS researchers. PMID:3224221

  11. Bibliometric analysis of martial arts monographs published in Spain (1906-2006

    Directory of Open Access Journals (Sweden)

    Mikel Pérez Gutiérrez

    2012-07-01

    Full Text Available This paper examines the martial arts monographs published in Spain between 1906 and 2006 from a bibliometric point of view. Starting from Pérez and Gutiérrez’s previous bibliography (2008, the total number of published monographs following the criteria of subject, decade and the combination of both was analyzed. The results showed a total of 2.036 books (1.285 original editions with a prevalence of Japanese and Chinese martial arts. A group of eight subjects exceeded a hundred volumes (karate, judo/jujutsu, taijiquan, wu-shu/kung fu, classics, qigong, philosophy, history and education, and aikido, with two patterns of bibliographic evolution appearing. The first, represented by Japanese martial arts considered as a group and martial arts focused on the utilitarian and/or sporting performance aspects (judo/jujutsu, karate and wu-shu/kung fu, developed increasingly until the 80’s when it followed a steady-state and/or drop. The second model, which characterises the Chinese martial arts group and martial arts mainly focused on healthy and/or spiritual aspects of training (taijiquan, qigong, aikido, has increased significantly from the 90’s until the present moment. The interpretation of these patterns and the evolution of the martial arts bibliographic production in Spain highlights some aspects such as the development of the Spanish society and sports practice, bibliographic production, reading habits, or the cultural influences of eastern countries on Spain.

  12. Analysis of Streptococcus bovis infections at a monographic oncological centre

    Directory of Open Access Journals (Sweden)

    Lozano TG

    2014-02-01

    interpretation of the results by the standards of the CLSI (Clinical and Laboratory Standards Institute, M100- S18. The results were: 14 strains (100% were sensitive to ampicillin (≤0.25 mcg / mL, amoxicillin-clavulanate (≤4/2 mg / mL, penicillin G (≤0.12 mcg / mL, cefotaxime (≤1 µg / mL, teicoplanin (≤8 mcg / mL, vancomycin (≤1 µg / mL and nitrofurantoin (≤32 mg / mL, 5 strains (35.71% were resistant to clindamycin (≥1 µg / mL, 6 (42.85% erythromycin (≥8 g / mL, 4 (28.57%, gentamicin (≥16 mg / mL, 3 (21.42%, tobramycin (≥16 mg / mL , 6 (42.85% to levofloxacin (≥8 mcg / mL, 8 (57.14% to ciprofloxacin (≥4 mg / mL, 9 (64.28% to tetracycline (≥8 mcg / mL and 6 (42.58% to trimethoprim-sulfamethoxazole (≥8/152 ug / mL.Regarding to the pathogenicity, there are reports on the degree of colonization of S. bovis (S. gallolyticus subsp. gallolyticus and colon cancer [1] ref code. It postulates several mechanisms involved in its pathogeny [2] ref code and it known the adhesion potential and invasion of endothelial cells or the ability to form biofilms [3] ref code, but if it is true, the relationship between colonization and oncogenesis is not entirely well defined.After analysing the isolated tumour epidemiology of our findings, no one of them was obtained from faecal samples or has been part of some study or active search for this microorganism.

  13. Fundamentos Basicos de Career Education. Monografia en Career Education. [Basic Fundamentals of Career Education. Monograph in Career Education].

    Science.gov (United States)

    Office of Education (DHEW), Washington, DC.

    This document is the Spanish translation of ED 145 222, A Primer for Career Education. In this monograph, a view of the basic nature of the career education effort is discussed under the following topics: the basis of need for career education; the meaning and goals of career education; the difference between career education and vocational…

  14. Administration of Literacy Programmes. Planning, Administration and Monitoring in Literacy; Portfolio of Literacy Materials, Series 2, Monograph 2.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and the Pacific.

    The second of three related monographs resulting from a Unesco regional literacy workshop in Asia, this booklet provides information useful to those administering national programs in literacy training in underdeveloped and developing nations. The introduction discusses the reasons why an effective administration machinery for literacy and adult…

  15. Planning of Literacy Programmes. Planning, Administration and Monitoring in Literacy; Portfolio of Literacy Materials, Series 2, Monograph 1.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and the Pacific.

    The first of three related monographs resulting from a Unesco regional literacy workshop in Asia, this booklet provides information useful to those designing national programs in literacy training for underdeveloped and developing nations. Following an introduction, the booklet discusses the formulation of both policy guidelines and policy…

  16. Monitoring of Literacy Programmes. Planning, Administration and Monitoring in Literacy; Portfolio of Literacy Materials, Series 2, Monograph 3.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and the Pacific.

    The third of three related monographs resulting from a Unesco regional literacy workshop in Asia, this booklet provides information useful to those designing national programs in literacy training for underdeveloped and developing nations. The booklet is divided into four parts. The first part discusses the monitoring of literacy programs,…

  17. Suitability of a liquid chromatography assay of neomycin sulfate to replace the microbiological assay for neomycin in USP Monographs.

    Science.gov (United States)

    Hanko, Valoran P; Rohrer, Jeffrey S

    2010-01-01

    The current USP National Formulary contains 65 Monographs for drug formulations containing neomycin. All 65 Monographs prescribe a bioassay for neomycin assay. This bioassay, based on cell culture, is labor intensive, has poor precision, and cannot be adapted for purity or identification. High-performance anion-exchange chromatography with integrated pulsed amperometric detection (HPAE-IPAD), a liquid chromatography technique, has been shown to be suitable for neomycin purity analysis and neomycin assay of an over-the-counter first aid cream (Hanko and Rohrer [17]). Here we propose that an HPAE-IPAD assay can replace the bioassay in the 65 neomycin-containing Monographs. We applied the HPAE-IPAD assay to four neomycin-containing drug products representing the four classes of formulations found in the 65 Monographs, liquid, solid, suspension, and cream. Each drug was analyzed with two chromatography systems, and on 3 separate days. For all products, HPAE-IPAD measurements were precise and accurate with respect to the label concentrations. There was also high accuracy for spike recovery of neomycin from the four drug products throughout 70-150% of the labeled concentration. These results suggest that an HPAE-IPAD assay would be an accurate assay for neomycin, and would be faster and more precise than the current bioassay.

  18. Access to Elementary Education in India: Politics, Policies and Progress. CREATE Pathways to Access. Research Monograph No. 44

    Science.gov (United States)

    Little, Angela W.

    2010-01-01

    This monograph examines progress in, and policies for, access to elementary education over the past 60 years, the role played by political factors in the process of policy formulation and implementation and the drivers and inhibitors of the implementation of reforms in elementary education in recent years in India. Drawing on interviews and…

  19. Value Orientations of Vietnamese Culture. Cultural Monograph No. 3. Bilingual Multicultural Education Training Project for School Psychologists and Guidance Counselors.

    Science.gov (United States)

    Hallman, Clemens L.; And Others

    This teacher training monograph deals with value orientations of cultures in general with specific reference to Vietnamese culture. The first two sections discuss the conceptual issues of value orientation and give axiological definitions of the six clusters used to describe cultural orientation. The third section introduces the section on…

  20. Social Development: Self Help Skills. A Performance-Based Early Childhood-Special Education Teacher Preparation Program. Monograph 13.

    Science.gov (United States)

    Mann, Lynne

    This monograph presents the self-help skills module of the social development curriculum portion of the Early Childhood-Special Education Teacher Preparation Program. Included are: (1) an ontogeny of self-help skills (feeding, dressing, toileting, and grooming) in young children; (2) a brief discussion of the relevance of self-help skills to the…

  1. Data Matching, Integration, and Interoperability for a Metric Assessment of Monographs

    DEFF Research Database (Denmark)

    Zuccala, Alesia Ann; Cornacchia, Roberto

    2016-01-01

    in a new Microsoft SQL database. The purpose of the experiment was to investigate co-varied metrics for a list of book titles based on their citation impact (from Scopus), presence in international libraries (WorldCat.org) and visibility as publically reviewed items (Goodreads). The results of our data......This paper details a unique data experiment carried out at the University of Amsterdam, Center for Digital Humanities. Data pertaining to monographs were collected from three autonomous resources, the Scopus Journal Index, WorldCat.org and Goodreads, and linked according to unique identifiers...... experiment highlighted current problems related citation indices and the way that books are recorded by different citing authors. Our research further demonstrates the primary problem of matching book titles as ‘cited objects’ with book titles held in a union library catalog, given that books are always...

  2. A short biography of Hubert Ludwig and a note on the publication dates of his monograph Die Seewalzen (1889-1892).

    Science.gov (United States)

    Reich, Mike

    2015-12-03

    The dates of publication of Hubert Ludwig's (1852-1913) comprehensive monograph Die Seewalzen [= Sea cucumbers] are reviewed. The precise publication dates of his volume, originally published in 16 fascicles and 8 parts/issues, delivered between 1889 and 1892, has been re-examined. Additionally, a short biographical note on Hubert Ludwig's life and a discussion of all new taxa introduced by him in his monograph is given.

  3. Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.

    Science.gov (United States)

    Chiu, Weihsueh A; Guyton, Kathryn Z; Martin, Matthew T; Reif, David M; Rusyn, Ivan

    2017-07-24

    Evidence regarding carcinogenic mechanisms serves a critical role in International Agency for Research on Cancer (IARC) Monograph evaluations. Three recent IARC Working Groups pioneered inclusion of the US Environmental Protection Agency (EPA) ToxCast program high-throughput screening (HTS) data to supplement other mechanistic evidence. In Monograph V110, HTS profiles were compared between perfluorooctanoic acid (PFOA) and prototypical activators across multiple nuclear receptors. For Monograph V112 -113, HTS assays were mapped to 10 key characteristics of carcinogens identified by an IARC expert group, and systematically considered as an additional mechanistic data stream. Both individual assay results and ToxPi-based rankings informed mechanistic evaluations. Activation of multiple nuclear receptors in HTS assays showed that PFOA targets peroxisome proliferator activated and other receptors. ToxCast assays substantially covered 5 of 10 key characteristics, corroborating literature evidence of "induces oxidative stress" and "alters cell proliferation, cell death or nutrient supply" and filling gaps for "modulates receptor-mediated effects." Thus, ToxCast HTS data were useful both in evaluating specific mechanistic hypotheses and in the overall evaluation of mechanistic evidence. However, additional HTS assays are needed to provide more comprehensive coverage of the 10 key characteristics of carcinogens that form the basis of current IARC mechanistic evaluations.

  4. Edited Volumes, Monographs, and Book Chapters in the Book Citation Index (BCI) and Science Citation Index (SCI, SoSCI, A&HCI)

    CERN Document Server

    Leydesdorff, Loet

    2012-01-01

    In 2011, Thomson-Reuters introduced the Book Citation Index (BCI) as part of the Science Citation Index (SCI). The interface of the Web of Science version 5 enables users to search for both "Books" and "Book Chapters" as new categories. Books and book chapters, however, were always among the cited references, and book chapters have been included in the database since 2005. We explore the two categories with both BCI and SCI, and in the sister databases for the social sciences (SoSCI) and the arts and humanities (A&HCI). Book chapters in edited volumes can be highly cited. Books contain many citing references, but are relatively less cited. We suggest that this may find its origin in the slower circulation of books then of journal articles. It is possible to distinguish scientometrically between monographs and edited volumes among the "Books". Monographs may be underrated in terms of citation impact or overrated using publication performance indicators because individual chapters are counted separately as ...

  5. Edited volumes, monographs and book chapters in the Book Citation Index (BKCI and Science Citation Index (SCI, SoSCI, A&HCI

    Directory of Open Access Journals (Sweden)

    Loet Leydesdorff

    2012-01-01

    Full Text Available In 2011, Thomson-Reuters introduced the Book Citation Index (BKCI as part of the Science Citation Index (SCI. The interface of the Web of Science version 5 enables users to search for both ′Books′ and ′Book Chapters′ as new categories. Books and book chapters, however, were always among the cited references, and book chapters have been included in the database since 2005. We explore the two categories with both BKCI and SCI, and in the sister social sciences (SoSCI and the arts & humanities (A&HCI databases. Book chapters in edited volumes can be highly cited. Books contain many citing references but are relatively less cited. This may find its origin in the slower circulation of books than of journal articles. It is possible to distinguish between monographs and edited volumes among the ′Books′ scientometrically. Monographs may be underrated in terms of citation impact or overrated using publication performance indicators because individual chapters are counted as contributions separately in terms of articles, reviews, and/or book chapters.

  6. Biowaiver monographs for immediate-release solid oral dosage forms: Zidovudine (azidothymidine).

    Science.gov (United States)

    Soares, Kelen C C; Rediguieri, Camila F; Souza, Jacqueline; Serra, Cristina Helena R; Abrahamsson, Bertil; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Dressman, Jennifer

    2013-08-01

    Literature data on the properties of zidovudine relevant to waiver of in vivo bioequivalence (BE) testing requirements for the approval of immediate-release (IR) solid oral dosage forms containing zidovudine alone or in combination with other active pharmaceutical ingredients (APIs) are reviewed. Solubility, dissolution, and permeability data for zidovudine, along with its dosing schedule, therapeutic index and pharmacokinetic properties, and reports related to BE/bioavailability were all taken into consideration. Data for solubility and permeability suggest that zidovudine belongs to Class I according to the Biopharmaceutics Classification System. Also, zidovudine is not a narrow therapeutic index drug. Although five out of 13 formulations tested in vivo (mostly of unreported composition) failed to show BE, it appears that in vitro studies performed according to biowaiver methods could predict in vivo behavior. Nevertheless, it is highly recommended that if a biowaiver is to be applied, excipient choices be limited to those found in IR drug products approved in International Conference on Harmonisation (ICH) or associated countries in the same dosage form (Table 2 of this monograph), in their usual amounts. These conclusions apply to products containing zidovudine as the only API and also to fixed combination products containing zidovudine with respect to the zidovudine component of the formulation.

  7. Biowaiver monographs for immediate-release solid oral dosage forms: quinine sulfate.

    Science.gov (United States)

    Strauch, Stefanie; Dressman, Jennifer B; Shah, Vinod P; Kopp, Sabine; Polli, James E; Barends, Dirk M

    2012-02-01

    The biowaiver approach permits evaluation of bioequivalence (BE) using a set of laboratory tests, obviating the need for expensive and time-consuming pharmacokinetic BE studies provided that both the active pharmaceutical ingredient and the formulations can meet the specified criteria. In the present monograph, the biowaiver-relevant data including solubility and permeability data, therapeutic use and therapeutic index, pharmacokinetic properties, reported excipient interactions, and BE/bioavailability studies of quinine sulfate are itemized and discussed. Quinine sulfate has borderline solubility characteristics and, on the whole, is highly permeable. Thus, depending on the jurisdiction, it is assigned to Biopharmaceutics Classification System class I or II. Although these characteristics would suggest a low risk of bioinequivalence among oral quinine products, a recent pharmacokinetic study showed bioinequivalence of two products. Even though quinine does not, strictly speaking, fit the definition of a narrow therapeutic index drug, it shows dose-related and, in some cases, irreversible side effects and toxicities at concentrations not far above the therapeutic concentration range. Taking all relevant aspects into consideration, a biowaiver cannot be recommended for new quinine immediate-release multisource products or major post-approval changes of already marketed quinine products, and in such cases, BE should be evaluated using an in vivo BE study.

  8. Biowaiver monographs for immediate-release solid oral dosage forms: codeine phosphate.

    Science.gov (United States)

    Dahan, Arik; Wolk, Omri; Zur, Moran; Amidon, Gordon L; Abrahamsson, Bertil; Cristofoletti, Rodrigo; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2014-06-01

    The present monograph reviews data relevant to applying the biowaiver procedure for the approval of immediate-release multisource solid dosage forms containing codeine phosphate. Both biopharmaceutical and clinical data of codeine were assessed. Solubility studies revealed that codeine meets the "highly soluble" criteria according to World Health Organization (WHO), the European Medicines Agency (EMA), and the United States Food and Drug Administration (US FDA). Codeine's fraction of dose absorbed in humans was reported to be high (>90%) based on cumulative urinary excretion of drug and drug-related material following oral administration. The permeability of codeine was also assessed to be high in both Caco-2 monolayers and rat intestinal perfusion studies. The main risks associated with codeine, that is, toxicity (attributed to CYP2D6 polymorphism) and its abuse potential, are present irrespective of the dosage form, and do not need to be taken into account for bioequivalence (BE) considerations. Taken together, codeine is a class 1 drug with manageable risk and is a good candidate for waiver of in vivo BE studies.

  9. Metrics and Science Monograph Collections at the Marston Science Library, University of Florida

    Directory of Open Access Journals (Sweden)

    Stephanie C. Haas

    2010-01-01

    Full Text Available As academic libraries are increasingly supported by a matrix of database functions, the use of data mining and visualization techniques offer significant potential for future collection development and service initiatives based on quantifiable data. While data collection techniques are still not standardized and results may be skewed because of granularity problems, faulty algorithms, and a host of other factors, useful baseline data is extractable and broad trends can be identified.The purpose of the current study is to provide an initial assessment of data associated with science monograph collection at the Marston Science Library (MSL, University of Florida. These sciences fall within the major Library of Congress Classification schedules of Q, S, and T, excluding TR, TT, and TX. The Rs are also excluded as these subjects are the responsibility of the Health Science Center Library which is connected with the medical school and the teaching hospital. The overall strategy of this project is to look at the potential science audiences within the university community and analyze data related to purchasing and circulation patterns, e-book usage, and interlibrary loan (ILL statistics. This paper presents the results from the academic year July 1, 2008 to June 30, 2009, because all data reservoirs needed were available for the circulation and ILL data. The Springer e-book study is based on 2009 data. The research team consisted of both librarians and technical support staff from MSL, the Acquisitions Department, the Cataloging Department, and the IT Department.

  10. Tools to Ensure Safe Medicines: New Monograph Tests in USP-NF

    Directory of Open Access Journals (Sweden)

    Catherine Sheehan

    2010-09-01

    Full Text Available This paper describes USP-NF compendial updates to six ‘high-priority” excipient monographs: Glycerin, Propylene Glycol, Sorbitol Solution, Sorbitol Sorbitan Solution, Noncrystallizing Sorbitol Solution and Maltitol Solution. The USP-NF revisions arose from the Food and DrugAdministration’s (FDA’s requests to include, as part of each monograph’s Identification test, a limit test to detect the presence of Diethylene Glycol (DEG, a toxic adulterant. These revisions alignwith the 2007 FDA Guidance for Industry: Testing of Glycerin for Diethylene Glycol (1, that drug product manufacturers perform a specific identity test for DEG on all containers of all lots ofglycerin before glycerin is used in the manufacture and preparation of drug products. This paper describes several risk factors due to a complex global excipient supply chain, nonspecific specifications, inadequate supply chain qualification, and poor understanding of regulations. Strengthening and conformance to compendial specifications is one of the tools necessary to mitigate risk and help prevent the next DEG adulteration that is part of USP’s efforts to ensure safe medicines.

  11. Clinical roundtable monograph. New alternatives in CLL therapy: managing adverse events.

    Science.gov (United States)

    Chanan-Khan, Asher; Kipps, Thomas; Stilgenbauer, Stephan

    2010-08-01

    Chronic lymphocytic leukemia (CLL) is a B-cell leukemia mainly affecting older adults. Historically, CLL has been regarded as an incurable disease, and treatment has been confined to cytotoxic chemotherapy regimens. However, prognosis for patients treated with these agents remained poor, prompting the development of new, targeted agents. The introduction of rituximab, a CD20-targeted monoclonal antibody, revolutionized the treatment for this disease. Rituximab in combination with fludarabine improved response rates and length of progression-free survival. The success of rituximab in this setting has prompted the development of many more investigational agents for CLL, including other antibody agents. However, as with any medication, the potential benefit achieved with CLL therapies is mitigated by the safety risk for the patient. These agents have been associated with adverse events such as immunosuppression, reactivation of cytomegalovirus, and infusion-related reactions that can occur with antibody administration. Adverse events can greatly affect the patient’s quality of life and ability to tolerate therapy. Management of adverse events is a critical component of the overall treatment strategy for CLL, particularly in elderly patients. In this clinical roundtable monograph, 3 expert physicians discuss the latest clinical studies evaluating the treatment of CLL, focusing on the adverse events associated with each agent and the potential interventions that can be used to manage their occurrence.

  12. Clinical roundtable monograph: Unmet needs in the management of chronic myelogenous leukemia.

    Science.gov (United States)

    Jabbour, Elias J; Bixby, Dale; Akard, Luke P

    2012-12-01

    Approximately 5,000 cases of chronic myelogenous leukemia (CML) are diagnosed each year in the United States. The introduction of tyrosine kinase inhibitors (TKIs) has dramatically improved survival time for many CML patients. Current first-line treatment options include imatinib and the second-generation agents nilotinib and dasatinib. Second- and third-line agents include nilotinib, dasatinib, bosutinib, and the new agent ponatinib. Despite the effectiveness of TKIs, some patients develop resistance or intolerance to these agents. A number of mutations of the BCR-ABL gene have been identified and are associated with TKI resistance. Patients may benefit from switching to a second-line TKI, undergoing hematopoietic stem cell transplant, or receiving newly emerging agents. Although early response is associated with improved patient outcome, clinicians lack tests that can determine which patients will benefit from which therapies. To ensure adequate response, patients should be monitored by both polymerase chain reaction and cytogenetic analysis of the bone marrow. This roundtable monograph reviews key unmet needs in patients with CML related to disease management and treatment options.

  13. Clinical roundtable monograph: new and emerging treatments for advanced prostate cancer.

    Science.gov (United States)

    George, Daniel J; Kantoff, Philip W; Lin, Daniel W

    2011-06-01

    Historically, the treatment of metastatic castration-resistant prostate cancer (CRPC) has been limited to chemotherapeutic regimens that did not improve patient survival. In 2004, clinical studies began to demonstrate significant improvements in patient outcomes, including overall survival, with docetaxel versus mitoxantrone chemotherapy. Since these pivotal trials, the combination of docetaxel plus prednisone has become a standard of care for patients with metastatic CRPC. However, the limited survival benefit achieved with this regimen prompted several investigations into the development of alternative therapeutic options. Recent advances have now led to an unprecedented number of new drug approvals within the past year, providing many new treatment options for patients with metastatic CRPC. Sipuleucel-T, considered a new paradigm in cancer treatment, is the first such immunotherapeutic agent approved by the US Food and Drug Administration. Other successes include abiraterone acetate, the first androgen biosynthesis inhibitor, and cabazitaxel, a novel microtubule inhibitor, both of which have demonstrated improved survival following docetaxel failure. The bone-targeting agent denosumab, also recently approved in this setting, offers these patients significant improvement in the prevention of skeletal-related events. The data supporting the approval of each of these agents are described in this monograph, as are current approaches in the treatment of metastatic CRPC and ongoing clinical trials of novel treatments and strategies. The experts also discuss several of the issues regarding the introduction of these novel agents into clinical practice for metastatic CRPC patients.

  14. Biowaiver monograph for immediate-release solid oral dosage forms: acetylsalicylic acid.

    Science.gov (United States)

    Dressman, Jennifer B; Nair, Anita; Abrahamsson, Bertil; Barends, Dirk M; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Zimmer, Markus

    2012-08-01

    A biowaiver monograph for acetylsalicylic acid (ASA) is presented. Literature and experimental data indicate that ASA is a highly soluble and highly permeable drug, leading to assignment of this active pharmaceutical ingredient (API) to Class I of the Biopharmaceutics Classification System (BCS). Limited bioequivalence (BE) studies reported in the literature indicate that products that have been tested are bioequivalent. Most of the excipients used in products with a marketing authorization in Europe are not considered to have an impact on gastrointestinal motility or permeability. Furthermore, ASA has a wide therapeutic index. Thus, the risks to the patient that might occur if a nonbioequivalent product were to be incorrectly deemed bioequivalent according to the biowaiver procedure appear to be minimal. As a result, the BCS-based biowaiver procedure can be recommended for approval of new formulations of solid oral dosage forms containing ASA as the only API, including both multisource and reformulated products, under the following conditions: (1) excipients are chosen from those used in ASA products already registered in International Conference on Harmonization and associated countries and (2) the dissolution profiles of the test and the comparator products comply with the BE guidance. Copyright © 2012 Wiley Periodicals, Inc.

  15. Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Amoxicillin Trihydrate.

    Science.gov (United States)

    Thambavita, Dhanusha; Galappatthy, Priyadarshani; Mannapperuma, Uthpali; Jayakody, Lal; Cristofoletti, Rodrigo; Abrahamsson, Bertil; Groot, Dirk W; Langguth, Peter; Mehta, Mehul; Parr, Alan; Polli, James E; Shah, Vinod P; Dressman, Jennifer

    2017-10-01

    Literature and experimental data relevant to waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release solid oral dosage forms containing amoxicillin trihydrate are reviewed. Solubility and permeability characteristics according to the Biopharmaceutics Classification System (BCS), therapeutic uses, therapeutic index, excipient interactions, as well as dissolution and BE and bioavailability studies were taken into consideration. Solubility and permeability studies indicate that amoxicillin doses up to 875 mg belong to BCS class I, whereas 1000 mg belongs to BCS class II and doses of more than 1000 mg belong to BCS class IV. Considering all aspects, the biowaiver procedure can be recommended for solid oral products of amoxicillin trihydrate immediate-release preparations containing amoxicillin as the single active pharmaceutical ingredient at dose strengths of 875 mg or less, provided (a) only the excipients listed in this monograph are used, and only in their usual amounts, (b) the biowaiver study is performed according to the World Health Organization-, U.S. Food and Drug Administration-, or European Medicines Agency-recommended method using the innovator as the comparator, and (c) results comply with criteria for "very rapidly dissolving" or "similarly rapidly dissolving." Products containing other excipients and those containing more than 875 mg amoxicillin per unit should be subjected to an in vivo BE study. Copyright © 2017 American Pharmacists Association®. All rights reserved.

  16. Tools to Ensure Safe Medicines: New Monograph Tests in USP-NF

    Directory of Open Access Journals (Sweden)

    Catherine Sheehan

    2010-06-01

    Full Text Available This paper describes USP-NF compendial updates to six ‘high-priority” excipient monographs: Glycerin, Propylene Glycol, Sorbitol Solution, Sorbitol Sorbitan Solution, Noncrystallizing Sorbitol Solution and Maltitol Solution. The USP-NF revisions arose from the Food and Drug Administration’s (FDA’s requests to include, as part of each monograph’s Identification test, a limit test to detect the presence of Diethylene Glycol (DEG, a toxic adulterant. These revisions align with the 2007 FDA Guidance for Industry: Testing of Glycerin for Diethylene Glycol (1, that drug product manufacturers perform a specific identity test for DEG on all containers of all lots of glycerin before glycerin is used in the manufacture and preparation of drug products. This paper describes several risk factors due to a complex global excipient supply chain, nonspecific specifications, inadequate supply chain qualification, and poor understanding of regulations. Strengthening and conformance to compendial specifications is one of the tools necessary to mitigate risk and help prevent the next DEG adulteration that is part of USP’s efforts to ensure safe medicines.

  17. NTP-CERHR monograph on the potential human reproductive and developmental effects of hydroxyurea.

    Science.gov (United States)

    2008-10-01

    The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for hydroxyurea to cause adverse effects on reproduction and development in humans. Hydroxyurea is a drug used to treat cancer, sickle cell disease, and thalassemia. It is the only treatment for sickle cell disease in children, aside from blood transfusion and, in severe cases, hematopoietic stem cell transplantation. Hydroxyurea is FDA-approved for use in adults with sickle cell anemia to reduce the frequency of painful crises and the need for blood transfusions. Hydroxyurea may be given to children and adults with sickle cell disease for an extended period of time or for repeated cycles of therapy. Treatment with hydroxyurea is associated with known side effects such as cytotoxicity and myelosuppression, and hydroxyurea is genotoxic (can damage DNA). CERHR selected hydroxyurea for evaluation because of: its increasing use for treatment of sickle cell disease in children and adults, knowledge that it inhibits DNA synthesis and is cytotoxic, and published evidence of reproductive and developmental toxicity in rodents. The results of this evaluation are published in the NTP-CERHR Monograph on Hydroxyurea, which includes the NTP Brief and Expert Panel Report on the Reproductive and Developmental Toxicity of Hydroxyurea. Additional information related to the evaluation process, including public comments received on the draft NTP Brief and the final expert panel report, are available on the CERHR website (http:// cerhr.niehs.nih.gov/). See hydroxyurea under "CERHR Chemicals" on the homepage or go directly to http://cerhr.niehs.nih.gov/chemicals/hydroxyurea/hydroxyurea-eval.html). The NTP reached the following conclusions on the possible effects of exposure to hydroxyurea on human reproduction or development. The possible levels of concern, from lowest to highest, are negligible concern, minimal concern, some concern, concern

  18. NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A.

    Science.gov (United States)

    Shelby, Michael D

    2008-09-01

    The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for bisphenol A to cause adverse effects on reproduction and development in humans. The CERHR Expert Panel on Bisphenol A completed its evaluation in August 2007. CERHR selected bisphenol A for evaluation because of the: widespread human exposure; public concern for possible health effects from human exposures; high production volume; evidence of reproductive and developmental toxicity in laboratory animal studies Bisphenol A (CAS RN: 80-05-7) is a high production volume chemical used primarily in the production of polycarbonate plastics and epoxy resins. Polycarbonate plastics are used in some food and drink containers; the resins are used as lacquers to coat metal products such as food cans, bottle tops, and water supply pipes. To a lesser extent bisphenol A is used in the production of polyester resins, polysulfone resins, polyacrylate resins, and flame retardants. In addition, bisphenol A is used in the processing of polyvinyl chloride plastic and in the recycling of thermal paper. Some polymers used in dental sealants and tooth coatings contain bisphenol A. The primary source of exposure to bisphenol A for most people is assumed to occur through the diet. While air, dust, and water (including skin contact during bathing and swimming) are other possible sources of exposure, bisphenol A in food and beverages accounts for the majority of daily human exposure. The highest estimated daily intakes of bisphenol A in the general population occur in infants and children. The results of this bisphenol A evaluation are published in an NTP-CERHR Monograph that includes the (1) NTP Brief and (2) Expert Panel Report on the Reproductive and Developmental Toxicity of Bisphenol A. Additional information related to the evaluation process, including the peer review report for the NTP Brief and public comments received on the draft NTP

  19. Biowaiver monographs for immediate release solid oral dosage forms: amodiaquine hydrochloride.

    Science.gov (United States)

    Nair, Anita; Abrahamsson, Bertil; Barends, Dirk M; Groot, D W; Kopp, Sabine; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2012-12-01

    The present monograph reviews data relevant to applying the biowaiver procedure for the approval of immediate release (IR) multisource solid dosage forms containing amodiaquine hydrochloride (ADQ) as the single active pharmaceutical ingredient (API). Both biopharmaceutical and clinical data of ADQ were assessed. Solubility studies revealed that ADQ meets the "highly soluble" criteria according to World Health Organization (WHO) and European Medicines Agency (EMA) but fails to comply with the United States Food and Drug Administration (US FDA) specifications. Although metabolism hints at high permeability, available permeability data are too scanty to classify ADQ inequivocably as a Class I drug substance. According to WHO and EMA guidances, ADQ would be conservatively categorized as a Class III drug, whereas according to the US FDA specifications, it would fall into Class IV. ADQ has a wide therapeutic index. Furthermore, no cases of bioinequivalent products have been reported in the open literature. As risks associated with biowaiving appear minimal and requirements for "highly soluble" API are met in the WHO and EMA jurisdictions, the biowaiver procedure can be recommended for bioequivalence (BE) testing of multisource IR products containing ADQ as the only API, provided the test product contains excipients used in ADQ products approved in International Conference of Harmonisation and associated countries, and in similar amounts. Furthermore, both comparator and test should conform to "very rapidly dissolving" product criteria (≥85% dissolution of the API in 15 min at pH 1.2, 4.5, and 6.8) and the labeling should specify that the product not be coadministered with high-fat meals. If the comparator and/or test product fails to meet these criteria, BE needs to be established by pharmacokinetic studies in humans.

  20. Prevalence of genotoxic chemicals among animal and human carcinogens evaluated in the IARC Monograph Series.

    Science.gov (United States)

    Bartsch, H; Malaveille, C

    1989-06-01

    To determine whether genotoxic and non-genotoxic carcinogens contribute similarly to the cancer burden in humans, an analysis was performed on agents that were evaluated in Supplements 6 and 7 to the IARC Monographs for their carcinogenic effects in humans and animals and for the activity in short-term genotoxicity tests. The prevalence of genotoxic carcinogens on four groups of agents, consisting of established human carcinogens (group 1, n = 30), probable human carcinogens (group 2A, n = 37), possible human carcinogens (group 2B, n = 113) and on agents with limited evidence of carcinogenicity in animals (a subset of group 3, n = 149) was determined. A high prevalence in the order of 80 to 90% of genotoxic carcinogens was found in each of the groups 1, 2A and 2B, which were also shown to be multi-species/multi-tissues carcinogens. The distribution of carcinogenic potency in rodents did not reveal any specific characteristic of the human carcinogens in group 1 that would differentiate them from agents in groups 2A, 2B and 3. The results of this analysis indicate that (a) an agent with unknown carcinogenic potential showing sufficient evidence of activity in in vitro/in vivo genotoxicity assays (involving as endpoints DNA damage and chromosomal/mutational damage) may represent a hazard to humans; and b) an agent showing lack of activity in this spectrum of genotoxicity assays should undergo evaluation for carcinogenicity by rodent bioassay, in view of the present lack of validated short-term tests for non-genotoxic carcinogens. Overall, this analysis implies that genotoxic carcinogens add more to the cancer burden in man than non-genotoxic carcinogens. Thus, identification of such genotoxic carcinogens and subsequent lowering of exposure will remain the main goal for primary cancer prevention in man.

  1. 欧盟传统草药专论述评%Review on community herbal monographs for traditional herbal medicinal products

    Institute of Scientific and Technical Information of China (English)

    邹文俊; 瞿礼萍; 叶祖光; 姬建新; 李伯刚

    2011-01-01

    该文通过对欧盟传统草药专论的建立与评价进行深入分析研究,关注传统草药专论的最新进展,阐明欧盟传统草药专论与简化注册的关系,为我国中药产品欧盟注册提供参考.%This article discusses the characteristics of cmmunity herbal monographs for traditional herbal medicinal products and its establishment procedure. It also reviews the new development of cmmunity traditional herbal monographs. The purpose is to clarify the relationship between cmmunity herbal monographs and simplified registration for traditional herbal medicinal product in European Union and provide reference to the registration of taditional Chinese mdicinal products in Europe.

  2. Inter-laboratory verification of European pharmacopoeia monograph on derivative spectrophotometry method and its application for chitosan hydrochloride.

    Science.gov (United States)

    Marković, Bojan; Ignjatović, Janko; Vujadinović, Mirjana; Savić, Vedrana; Vladimirov, Sote; Karljiković-Rajić, Katarina

    2015-01-01

    Inter-laboratory verification of European pharmacopoeia (EP) monograph on derivative spectrophotometry (DS) method and its application for chitosan hydrochloride was carried out on two generation of instruments (earlier GBC Cintra 20 and current technology TS Evolution 300). Instruments operate with different versions of Savitzky-Golay algorithm and modes of generating digital derivative spectra. For resolution power parameter, defined as the amplitude ratio A/B in DS method EP monograph, comparable results were obtained only with algorithm's parameters smoothing points (SP) 7 and the 2nd degree polynomial and those provided corresponding data with other two modes on TS Evolution 300 Medium digital indirect and Medium digital direct. Using quoted algorithm's parameters, the differences in percentages between the amplitude ratio A/B averages, were within accepted criteria (±3%) for assay of drug product for method transfer. The deviation of 1.76% for the degree of deacetylation assessment of chitosan hydrochloride, determined on two instruments, (amplitude (1)D202; the 2nd degree polynomial and SP 9 in Savitzky-Golay algorithm), was acceptable, since it was within allowed criteria (±2%) for assay deviation of drug substance, for method transfer in pharmaceutical analyses. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Psychotherapy and Counseling in the Treatment of Drug Abuse [Technical Review] (Rockville, Maryland, May 18-19, 1989). National Institute on Drug Abuse Research Monograph Series 104.

    Science.gov (United States)

    Onken, Lisa Simon; Blaine, Jack D.

    This monograph is based on the papers from a technical review. These papers are included: (1) Psychotherapy and Counseling Research in Drug Abuse Treatment: Questions, Problems, and Solutions (Lisa Onken, Jack Blaine); (2) Psychotherapy and Counseling for Methadone-Maintained Opiate Addicts: Results of Research Studies (George Woody, A. T.…

  4. A monograph of the fern Genus Microsorum (Polypodiaceae) including an attempt towards a reconstruction of the phylogenetic history of the microsoroids

    NARCIS (Netherlands)

    Bosman, M.T.M.

    1991-01-01

    This revision is a monographic treatment of the fern genus Microsorum (Polypodiaceae). To elucidate the problematic generic delimitation and systematic position of this genus an additional selection of 26 possibly related species was also studied. Most of these related species are traditionally plac

  5. The Impact of Socioeconomic Development and Ecological Change on Health and Nutrition in Latin America. Cornell International Nutrition Monograph Series, Number 9 (1981).

    Science.gov (United States)

    Solimano, Giorgio R.; Chapin, Georganne

    This monograph presents an examination of patterns which emerge from the interrelationship between development, environment, and health and nutrition in Latin America. First, the authors consider the components of this interrelationship, discussing the inseparability of health problems such as malnutrition, fecally-borne and parasitic diseases,…

  6. The Genetics Revolution: Programs and Issues for the Community College. A Monograph Highlighting the Winners of the Exxon Education Foundation Innovation Awards.

    Science.gov (United States)

    Mays, Marilyn Elaine, Ed.

    Presented at a 1996 conference on the implications of the Human Genome Project for community and technical colleges, the 30 papers included in this monograph describe methods for incorporating genetics studies into the two-year college curriculum. Among the papers provided are: (1) "Facing the Unknown: The Ethical Challenges of…

  7. Development of monograph titled "augmented chemistry aldehida & keton" with 3 dimensional (3D) illustration as a supplement book on chemistry learning

    Science.gov (United States)

    Damayanti, Latifah Adelina; Ikhsan, Jaslin

    2017-05-01

    Integration of information technology in education more rapidly performed in a medium of learning. Three-dimensional (3D) molecular modeling was performed in Augmented Reality as a tangible manifestation of increasingly modern technology utilization. Based on augmented reality, three-dimensional virtual object is projected in real time and the exact environment. This paper reviewed the uses of chemical learning supplement book of aldehydes and ketones which are equipped with three-dimensional molecular modeling by which students can inspect molecules from various viewpoints. To plays the 3D illustration printed on the book, smartphones with the open-source software of the technology based integrated Augmented Reality can be used. The aims of this research were to develop the monograph of aldehydes and ketones with 3 dimensional (3D) illustrations, to determine the specification of the monograph, and to determine the quality of the monograph. The quality of the monograph is evaluated by experiencing chemistry teachers on the five aspects of contents/materials, presentations, language and images, graphs, and software engineering, resulted in the result that the book has a very good quality to be used as a chemistry learning supplement book.

  8. Transfer Students in Higher Education: Building Foundations for Policies, Programs, and Services that Foster Student Success. The First-Year Experience Monograph Series No. 54

    Science.gov (United States)

    Poisel, Mark Allen, Ed.; Joseph, Sonya, Ed.

    2011-01-01

    "Transfer Students in Higher Education" presents what individuals know about transfer students, addresses assumptions and myths about the transfer experience, and explores the changing demographics of this student group. Adopting a student-centered approach, the monograph offers strategies to begin (and continue) the work of serving students and…

  9. Bullying and School Attendance: A Case Study of Senior High School Students in Ghana. CREATE Pathways to Access. Research Monograph No. 41

    Science.gov (United States)

    Dunne, Mairead; Bosumtwi-Sam, Cynthia; Sabates, Ricardo; Owusu, Andrew

    2010-01-01

    This monograph analyses the effects of bullying on school attendance among senior high school students in Ghana. A strong correlation is found between being bullied and having poor attendance. The effects of emotional problems and of peer friendships on this correlation are then examined. For both boys and girls, having emotional problems is…

  10. Writing on Your Feet: Reflective Practices in City as Text™. A Tribute to the Career of Bernice Braid. National Collegiate Honors Council Monograph Series

    Science.gov (United States)

    Long, Ada, Ed.

    2014-01-01

    City as Text™ (CAT) is one of the earliest structural forms of experiential learning created and practiced in the United States. This monograph explores the centrality of writing in the process of active learning, focusing primarily on the Faculty Institutes and Honors Semesters that foster CAT experiences. All manifestations of this pedagogical…

  11. What Do They Use? Where Do They Get It? An Interdisciplinary Citation Analysis of Latin American Studies Faculty Monographs, 2004-2013

    Science.gov (United States)

    Ostos, Manuel

    2017-01-01

    This citation analysis examines the ability of the local collection at the Pennsylvania State University to meet the needs of global and area studies researchers focusing on monographs published by faculty members on Latin American studies in a ten-year period. The study focuses on book use to address the tempting notion that packages and online…

  12. The Economic Value of Breastfeeding (With Results from Research Conducted in Ghana and the Ivory Coast). Cornell International Nutrition Monograph Series Number 6.

    Science.gov (United States)

    Greiner, Ted; And Others

    This monograph focuses attention on economic considerations related to infant feeding practices in developing countries. By enlarging on previous methodologies, this paper proposes to improve the accuracy of past estimates of the economic value of human milk, or more specifically, the practice of breastfeeding. The theoretical model employed…

  13. The Decline in Breastfeeding: An Analysis of the Role of the Nestle Corporation from Two Perspectives. Cornell International Nutrition Monograph Series, Number 11 (1982).

    Science.gov (United States)

    Campbell, Carolyn E.

    An attempt is made to analyze the ascendancy of formula feeding of infants in terms of the conflicting ideologies of Marxism and capitalism. The decline of breastfeeding is traced, and is linked with the interrelated phenomena of free market economics and the domination of women by men in Western society. The monograph has two sections:…

  14. The Economic Value of Breastfeeding (With Results from Research Conducted in Ghana and the Ivory Coast). Cornell International Nutrition Monograph Series Number 6.

    Science.gov (United States)

    Greiner, Ted; And Others

    This monograph focuses attention on economic considerations related to infant feeding practices in developing countries. By enlarging on previous methodologies, this paper proposes to improve the accuracy of past estimates of the economic value of human milk, or more specifically, the practice of breastfeeding. The theoretical model employed…

  15. Adult Education in the Federal Republic of Germany: Scholarly Approaches and Professional Practice. Monographs on Comparative and Area Studies in Adult Education.

    Science.gov (United States)

    Mader, Wilhelm, Ed.

    This monograph offers insight into the development of the conceptual basis, scholarly inquiry, and professional practice of adult education in West Germany from the end of World War II to the German reunification. Introductory materials are an "Introduction" (Wilhelm Mader) and "Translator's Note and Acknowledgements" (Martin…

  16. Monograph of Arctium L. (Asteraceae). Generic delimitation (including Cousinia Cass, p.p.), revision of the species, pollen morphology, and hybrids

    NARCIS (Netherlands)

    Duistermaat, Helena

    1996-01-01

    The subject of this thesis is a monograph of the genus Arctium, now including also five species formerly placed into Cousinia. Based on herbarium material and some field observations, this study presents new insights on three subjects: a) the generic delimitation of Arctium, b) the species

  17. Corrections and Juvenile Justice: Current Education Practice for Youth with Learning and Other Disabilities. Monograph Series on Education, Disability and Juvenile Justice.

    Science.gov (United States)

    Howell, Kenneth W.; Wolford, Bruce I.

    This monograph, one of a series on youth with disabilities and the juvenile justice system, focuses on the educational services provided to youth with behavioral and cognitive disabilities placed in the juvenile justice system. It reports on a review of correctional system monitoring reports, materials from enforcement actions taken against…

  18. Monograph of Arctium L. (Asteraceae). Generic delimitation (including Cousinia Cass, p.p.), revision of the species, pollen morphology, and hybrids

    NARCIS (Netherlands)

    Duistermaat, Helena

    1996-01-01

    The subject of this thesis is a monograph of the genus Arctium, now including also five species formerly placed into Cousinia. Based on herbarium material and some field observations, this study presents new insights on three subjects: a) the generic delimitation of Arctium, b) the species delimitat

  19. Postcolonial Times: Lock the Gate or Pull Down the Fences? A special Monograph Edition

    Directory of Open Access Journals (Sweden)

    Bill Boyd

    2013-06-01

    understands but that does not actually express what you mean, or speak your own language and risk the other party not understanding what you mean. Copyright © Bill Boyd 2013. This text may be archived and redistributed both in electronic form and in hard copy, provided that the author and journal are properly cited and no fee is charged. Coolabah, No.12, 2013, ISSN 1988-5946, Observatori: Centre d’Estudis Australians, Australian Studies Centre, Universitat de Barcelona 2 From a postcolonial studies perspective, this example reminds students of two key processes. First, students need to master the intellectual skills of the humanities in order to provide critical analysis of social situations. Secondly, students need to know that, as western scholars, they are as much part of any postcolonial problem as those in power, and therefore need to develop good reflective skills and to learn to think ‘otherwise’. This invited monograph is the text of the lecture, supplemented with further comments and illustrations, delivered to second year Humanities students at the University of Barcelona, Catalonia, on Monday 8th April 2013

  20. Screening assays for carcinogenic agents and mixtures: an appraisal based on data in the IARC Monograph series.

    Science.gov (United States)

    Bartsch, H; Malaveille, C

    1990-01-01

    To determine whether genotoxic and non-genotoxic carcinogens contribute similarly to the cancer burden in humans and which types of short-term test are more relevant for predicting human hazards, an analysis was performed on agents that were evaluated in IARC Monographs Supplements 6 and 7 for their carcinogenic effects in humans and animals and for activity in short-term genotoxicity tests. The prevalence of genotoxicity among four groups of agents, consisting of established human carcinogens (group 1, n = 30), probable human carcinogens (group 2A, n = 37), possible human carcinogens (group 2B, n = 113) and agents with limited evidence of carcinogenicity in animals (a subset of group 3, n = 66) was determined. Each of the groups 1, 2A and 2B contained a high proportion (80-90%) of genotoxic carcinogens, which were also multi-species or multi-tissue carcinogens. The distribution of carcinogenic potency in rodents did not reveal any specific characteristic of the human carcinogens in group 1 that would differentiate them from agents in groups 2A, 2B and many in group 3. Although limited by the data-base available through the Monographs series, this analysis implies that genotoxic carcinogens add more to the human cancer burden than non-genotoxic carcinogens. Thus, the continued use of in vitro/in vivo short-term tests, involving as endpoints DNA chromosomal or mutational damage, to identify genotoxic carcinogens or in the isolation of carcinogenic components in complex mixtures is fully justified. It is concluded that (a) an agent or complex mixture with unknown carcinogenic potential showing sufficient evidence of activity in genotoxicity assays in vitro or in vivo is likely to represent a hazard to humans and (b) an agent or complex mixture showing lack of activity in this spectrum of genotoxicity assays should undergo evaluation for carcinogenicity for rodent bioassay, in view of the present lack of validated short-term tests for non-genotoxic carcinogens.

  1. On the Standard Awareness of References Citing in Monographs and Copyright Protection%文献征引中的规范意识与著作权保护研究

    Institute of Scientific and Technical Information of China (English)

    张连举

    2015-01-01

    Monographs can not be completed without citing references.References citing in monographs plays the role of offering supporting evidence and disclosing information sources, which is beneficial to reader's re-trieval and statistical appraisal.However, some monographs pay less attention to the correctness and standard of references citing, such as disorderly labeling system, improper mode of references citing, poor awareness of copy-right, etc..The statistical errors affect the reliability of academic statistics and bring negative influences to tracing and searching, which makes academic appraisal work lack of accuracy and objectivity.Therefore, the standard awareness of references citing shall be improved by paying more attention to the scientific and correct citing of ref-erences, editors'proofreading and copyright protection.%学术论著离不开文献征引。文献征引对论著内容起着支持佐证和揭示其信息来源的作用,既便利读者检索又有益于统计评价。但有些论著对文献征引著录的正确性、规范性重视程度不够,标注体系混乱,征引方式失妥,版权意识淡薄,其数据的误差影响了学术统计源的可靠性,对追踪检索也带来不利因素,使得学术评价工作失去了准确性和客观性。这就要求提升文献征引的规范意识,重视引文的科学性和准确性,注意编辑校对,加强文献征引的著作权保护。

  2. MEDLINE收录的高压氧医学专题论文著者群研究%Author distribution of monographic papers on HBO in MEDLIN

    Institute of Scientific and Technical Information of China (English)

    王侠; 甘辉亮; 吕传禄

    2009-01-01

    Objective Through statistical analyses of the distribution characteristics of international monographers on hyperbaric oxygenation,collected by MEDLINE (1998 -2007 ),the number of monographs from 60 countries was compared and analyzed.With the above work done,the most important corporate authors and core authors were identified.%通过对MEDLINE(1998-2007)收录的国际高压氧医学专题论文著者分布特征进行统计分析,对比研究了60个国家的高压氧医学专题论文发表情况,确定了国际高压氧医学研究中高产机构和核心著者.

  3. Molecular phylogeny, biogeography, and an e-monograph of the papaya family (Caricaceae) as an example of taxonomy in the electronic age

    OpenAIRE

    Antunes Carvalho, Fernanda

    2014-01-01

    This dissertation addresses an issue of key importance to the field of systematics, namely how to foster taxonomic work and the dissemination of knowledge about species by taking full advantage of electronic data and bioinformatic tools. I tested and applied modern systematic tools to produce an electronic monograph of a family of flowering plants, Caricaceae. In addition to a taxonomic revision, a molecular phylogeny of the family that includes representatives of all biological species clari...

  4. 浅谈如何提高科技类学术专著原稿的质量%How to Improve the Tech Academic Monographs Original Quality

    Institute of Scientific and Technical Information of China (English)

    李兰英

    2014-01-01

    Tech academic monographs originals there is often a variety of problems, this paper analyzes the various issues manifestations, causes, and proposed solutions.%科技类学术专著原稿常常存在各种各样的问题,本文分析了各类问题的表现形式、产生的原因,并提出了解决措施。

  5. A dose-response study in animals to evaluate the anticoagulant effect of the stage 2 unfractionated heparin USP monograph change.

    Science.gov (United States)

    Honchel, R; Carraway, J; Gopee, N; Callicott, R; Chen, J; Patton, R; Xu, Q; Zalkkar, J; Laniyonu, A; Krefting, I; Cato, M; Robie-Suh, K; Rieves, R

    2011-08-01

    The United States Pharmacopeia (USP) monograph for unfractionated heparin (UFH) was revised in October 2009. This revision was anticipated, based upon in vitro tests, to reduce UFH potency by approximately 10%. To study the potential in vivo consequences of the monograph change, we evaluated activated partial thromboplastin time (aPTT) and activated clotting time (ACT) responses in animals. Female mini-pigs and monkeys (n=8/species) were administered intravenously 60, 54, 48, or 42 U/kg and 50, 45, 40, or 35 U/kg "old" (pre-USP revision) UFH, respectively, in a Williams 4×4 crossover design. Blood samples for aPTT and ACT were collected at 15 min after dosing. The same study design was then repeated using "new" (post-USP revision) UFH. Mean "new" UFH aPTT and ACT values were generally lower than those for "old" UFH although individual animal responses varied considerably. The aPTT and ACT response was generally dose-proportional for both "old" and "new" UFH. These studies indicate that the USP monograph alteration for UFH may result in a modest reduction in the anticoagulant response across a population, but the variability in animal responses underscores the importance of individualization of clinical UFH dosing and the importance of anticoagulant test monitoring. Published by Elsevier Inc.

  6. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of 1-Bromopropane (1-BP).

    Science.gov (United States)

    2003-10-01

    The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for 1-bromopropane to cause adverse effects on reproduction and development in humans. 1-Bromopropane was selected for evaluation due to recent consideration of 1-bromopropane as a replacement chemical for hydrochlorofluorocarbons and chlorinated solvents. 1-Bromopropane is used in spray adhesives and in cleaning metal and electronic components; as a solvent for fats, waxes, or resins; and as an intermediate in the synthesis of pharmaceuticals, insecticides, quaternary ammonium compounds, flavors, or fragrances. The results of this evaluation on 1-brompropane are published in a NTP-CERHR monograph which includes: 1) the NTP Brief, 2) the Expert Panel Report on the Reproductive and Developmental Toxicity of 1-Bromopropane, and 3) public comments received on the Expert Panel Report. As stated in the NTP Brief, the NTP reached the following conclusions regarding the possible effects of exposure to 1-bromopropane on human development and reproduction. No data were available on 1-bromopropane exposures in the general US population. Therefore, conclusions were based on the available occupational exposure data and on studies in humans and laboratory animals. First, there is serious concern for reproductive and developmental effects at the upper end of the human occupational exposure range (18-381 ppm). Adverse developmental and/or reproductive effects have been reported in animal studies at exposure levels of >/=200 ppm. Second, there is minimal concern for reproductive and developmental effects when humans are exposed at the lower end of the human occupational exposure range (0.04-0.63 ppm). This level is at least 300- fold lower than the no effect level identified from reproductive studies in laboratory animals. These conclusions are based upon limited occupational inhalation exposure data. It is likely that worker exposures

  7. HUMAN IN SPEECH DIMENSION REVIEW OF THE MONOGRAPH: KARASIK V. I. YAZYKOVOYE PROYAVLENIYE LICHNOSTI: MONOGRAFIYA [LINGUISTIC MANIFESTATION OF PERSONALITY] / KARASIK V.I.; VOLGOGRADSKIY GOS. SOTSIALNO-PEDAGOGICHESKIY UN-T, NAUCHNO-ISSLEDOVATELSKAYA LABORATORIYA «AKSIOLOGICHESKAYA LINGVISTIKA». VOLGOGRAD: PARADIGMA, 2014. 449 P

    Directory of Open Access Journals (Sweden)

    VASILEVA V.V.

    2015-01-01

    Full Text Available The review presents to the reader a monographic study by V. Karasik, performed in the mainstream of anthropological linguistics. The peer-reviewed monograph suggests a model for study of human in its linguistic manifestation: as elements of this model serve the "axiological situation, conceptualization of the value and discourse as the embodiment of values". The author of the monograph suggests an issue of the discursive modes of an individual for discussion and considers the typological characteristics of the discourses. Particular attention is given to the typological characteristics of media discourse. The monograph also presents the poetic dimension of personality, which considers poetic reflection, poetic impact, and poetic technique.

  8. HUMAN IN SPEECH DIMENSION REVIEW OF THE MONOGRAPH: KARASIK V. I. YAZYKOVOYE PROYAVLENIYE LICHNOSTI: MONOGRAFIYA [LINGUISTIC MANIFESTATION OF PERSONALITY] / KARASIK V.I.; VOLGOGRADSKIY GOS. SOTSIALNO-PEDAGOGICHESKIY UN-T, NAUCHNO-ISSLEDOVATELSKAYA LABORATORIYA «AKSIOLOGICHESKAYA LINGVISTIKA». VOLGOGRAD: PARADIGMA, 2014. 449 P

    Directory of Open Access Journals (Sweden)

    VASILEVA V.V.

    2015-12-01

    Full Text Available The review presents to the reader a monographic study by V. Karasik, performed in the mainstream of anthropological linguistics. The peer-reviewed monograph suggests a model for study of human in its linguistic manifestation: as elements of this model serve the "axiological situation, conceptualization of the value and discourse as the embodiment of values". The author of the monograph suggests an issue of the discursive modes of an individual for discussion and considers the typological characteristics of the discourses. Particular attention is given to the typological characteristics of media discourse. The monograph also presents the poetic dimension of personality, which considers poetic reflection, poetic impact, and poetic technique.

  9. [The classics of Italian nephrology: the monograph "La nefropatia diabetica" (Diabetic nephropathy) by Luigi Scapellato (1918-1998)].

    Science.gov (United States)

    Fogazzi, G B

    2007-01-01

    This monograph, published in 1953, describes the findings observed by the author in a cohort of patients affected by diabetes mellitus and renal disease. From a pathological standpoint, the typical renal lesion is represented by ''nodular intercapillary glomerulosclerosis'', which is present in 8 out of 20 patients at postmortem. Marked proteinuria and edema are the most typical clinical features. Urinary sediment examination is the only test allowing to differentiate diabetic nephropathy from other glomerular diseases. In the initial phases, the glomerular filtration rate is increased rather than reduced. The evolution is almost invariably towards end-stage renal disease, and a hypoglucidic diet and insulin are the only therapeutic modalities available. Today this work shows us, on the one hand, how many uncertainties still existed about diabetic nephropathy 17 years after its first description by Kimmelstiel and Wilson in 1936. On the other hand, it shows how much relevant and still valid information was already known at the time. Luigi Scapellato, who is almost completely forgotten today, began his career at the Clinica Medica of the University of Rome under the guidance of Cesare Frugoni (1881-1978). In 1959, he moved to Syracuse (Sicily) to work as director of the internal medicine unit of the ''Umberto I'' Hospital. In April 1957 he was among the 13 founders of the Italian Society of Nephrology.

  10. Heparin sodium compliance to USP monograph: structural elucidation of an atypical 2.18 ppm NMR signal.

    Science.gov (United States)

    Mourier, Pierre A J; Guichard, Olivier Y; Herman, Fréderic; Viskov, Christian

    2012-01-01

    The ¹H nuclear magnetic resonance (NMR) acceptance criteria in the new heparin US Pharmacopeia (USP) monograph do not take into account potential structural modifications responsible for any extra signals observed in ¹H NMR spectra, some purified heparins may be non-compliant under the proposed new USP guidelines and incorrectly classified as unsuitable for pharmaceutical use. Heparins from the "ES" source, containing an extra signal at 2.18 ppm, were depolymerized under controlled conditions using heparinases I, II, and III. The oligosaccharides responsible for the 2.18 ppm signal were enriched using orthogonal chromatographic techniques. After multiple purification steps, we obtained an oligosaccharide mixture containing a highly enriched octasaccharide bearing the structural modification responsible for the extra signal. Following heparinase I depolymerization, a pure tetrasaccharide containing the fingerprint structural modification was isolated for full structural determination. Using 1D and 2D ¹H NMR spectroscopy, the structural moiety responsible for the extra signal at 2.18 ppm was identified as an acetyl group on the heparin backbone, most likely resulting from a very minor manufacturing process side reaction that esterifies the uronic acid at position 3. Such analytical peculiarity has always been present in this heparin source and it was used safety over the years. Copyright © 2012 Elsevier B.V. All rights reserved.

  11. Clinical roundtable monograph: Recent advances in the treatment of mantle cell lymphoma: a post-ASH 2009 discussion.

    Science.gov (United States)

    Czuczman, Myron S; Leonard, John P; Williams, Michael E

    2010-04-01

    Mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkin lymphoma characterized by CD5 expression and a t(11;14) cytogenetic translocation that results in overexpression of the cyclin D1 gene. Currently, there is no standard of care for the treatment of MCL, and patient prognosis is poor. Traditional treatments for MCL rely on conventional chemotherapy agents, including cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). The addition of the immunotherapeutic agent rituximab to this regimen (CHOP-R) has helped to improve patient response to treatment. These treatments often provide good initial responses that are difficult to sustain. Therefore, a number of newer agents and combinations have been investigated to produce more durable benefit. Several of these advances were reported at the 51st American Society of Hematology (ASH) Annual Meeting and Exposition, held December 5-8, 2009 in New Orleans, Louisiana. In this clinical roundtable monograph, new strategies in the treatment of MCL are discussed. Some of the drug classes examined here are proteasome inhibitors, inhibitors of the protein mammalian target of rapamycin (mTOR), the unique alkylating agent bendamustine, and immunomodulatory agents.

  12. 60 YEARS OF NEUROENDOCRINOLOGY: Celebrating the brain's other output-input system and the monograph that defined neuroendocrinology.

    Science.gov (United States)

    Coen, Clive W

    2015-08-01

    The brain's unimaginably complex operations are expressed in just two types of output: muscle activity and hormone release. These are the means by which the brain acts beyond its bony casing. Muscle-mediated actions (such as speaking, writing, pupillary reflexes) send signals to the outside world that may convey thoughts, emotions or evidence of neurological disorder. The outputs of the brain as a hormone secreting gland are usually less evident. Their discovery required several paradigm shifts in our understanding of anatomy. The first occurred in 1655. Exactly 300 years later, Geoffrey Harris' monograph Neural control of the pituitary gland launched the scientific discipline that is now known as neuroendocrinology. His hypotheses have stood the test of time to a remarkable degree. A key part of his vision concerned the two-way 'interplay between the central nervous system and endocrine glands'. Over the past 60 years, the importance of this reciprocity and the degree to which cerebral functions are influenced by the endocrine environment have become increasingly clear. © 2015 Society for Endocrinology.

  13. DEVELOPMENT OF METHOD OF QUALITATIVE ANALYSIS OF BIRD CHERRY FRUIT FOR INCLUSION IN THE MONOGRAPH OF STATE PHARMACOPOEIA OF UKRAINE

    Directory of Open Access Journals (Sweden)

    Lenchyk L.V.

    2016-06-01

    Full Text Available Introduction. Bird cherry Padus avium Mill, Rosaceae, is widespread in Ukraine, especially in forests and forest-steppe areas. Bird cherry fruits have long been used in medicine and is a valuable medicinal raw materials. They stated to posess astringent, anti-inflammatory, phytoncidal properties. Bird cherry fruits are included in the USSR Pharmacopoeia IX ed., The State Pharmacopoeia of the Russian Federation, The State Pharmacopoeia of Republic of Belarus. In Ukraine there are no contemporary normative documents for this medicinal plant material, therefore it is the actual to develop projects in the national monographs "dry bird cherry fruit" and "fresh bird cherry fruit" to be included in the State Pharmacopoeia of Ukraine. According to European Pharmacopoeia recommendation method of thin-layer chromatography (TLC is prescribed only for the identification of the herbal drug. The principles of thin-layer chromatography and application of the technique in pharmaceutical analysis are described in State Pharmacopoeia of Ukraine. As it is effective and easy to perform, and the equipment required is inexpensive, the technique is frequently used for evaluating medicinal plant materials and their preparations. The TLC is aimed at elucidating the chromatogram of the drug with respect to selected reference compounds that are described for inclusion as reagents. Aim of this study was to develop methods of qualitative analysis of bird cherry fruits for a monograph in the State Pharmacopoeia of Ukraine (SPU. Materials and Methods. The object of our study was dried bird cherry fruits (7 samples and fresh bird cherry fruits (7 samples harvested in 2013-2015 in Kharkiv, Poltava, Luhansk, Sumy, Lviv, Mykolaiv regions and the city Mariupol. Samples were registered in the department of SPU State Enterprise "Pharmacopeia center". In accordance with the Ph. Eur. and SPU requirements in "identification C" determination was performed by TLC. TLC was performed on

  14. PREDICTING NORMATIVE AND PROBLEMATIC FAMILY PATHWAYS TO THE TRANSITION TO SIBLINGHOOD: COMMENTARY ON VOLLING ET AL.'S MONOGRAPH.

    Science.gov (United States)

    Howe, Nina

    2017-09-01

    Volling et al.'s monograph provides a rich, thoughtful, and rigorous account of how the transition to siblinghood is experienced by the first-born child and the family. In their comprehensive longitudinal study, they followed 241 families from the prenatal period before the second-born's birth until this child was 12-months old. Siblings are a critical, but understudied, relationship in children's development; the challenges posed in researching sibling dynamics in the context of the family are discussed. Prior psychodynamic and developmental research literature is critiqued, which places the current study into perspective and indicates the important theoretical frameworks (i.e., developmental psychopathology and developmental ecological systems) employed by Volling et al. to advance our understanding of this critical transition in the life of the family. The longitudinal study design, sample characteristics, identification of possible trajectories of adjustment (or not) to the birth of the sibling, and selection of family and child variables are addressed. The sophisticated statistical methods (Growth Mixture Modeling and data mining procedures) employed to predict child adjustment in association with parenting variables over time and sibling relationship quality at 12 months identified low- and high-risk trajectories on the seven subscales of the Child Behavior Check List (CBCL). This afforded a nuanced investigation of a variety of potentially problematic child behaviors (e.g., aggression, withdrawal, negative emotionality, somatic problems) in association with parenting behaviors. A final discussion included study limitations, significant strengths, and implications for clinicians and other professionals. The study's conclusion is that most children and families are resilient, take the birth of a sibling in their stride, and do not exhibit empirical evidence of a developmental crisis, as argued by earlier psychodynamic authors. © 2017 The Society for Research

  15. Pierre Janet's addition to Charles-Hubert-Antoine Despine's "Old but very curious" Estelle L'Hardy monograph.

    Science.gov (United States)

    Brown, Carole Koepke

    2008-01-01

    In the magisterial book The Discovery of the Unconscious, Ellenberger (1970) showed a keen appreciation for practitioners of many schools of therapy, including those who practiced animal magnetism (hypnotism). He credited Despine and Janet for their contributions to dynamic psychiatry and documented Janet's intellectual debt to Despine's successful magnetic treatment of 11-year-old Estelle's hysteria (dissociative disorder). No scholarship, however, has identified Janet's unique addition to Despine's 1838/1839 monograph--written decades before Janet's birth. Supplementing Despine's account of Estelle's minor fall that precipitated her paralysis, Janet reported that Estelle disobeyed her mother by quarreling with a friend, soiled her frock, experienced fright and shame, and sought to conceal everything from her mother. The author argues (a) that Despine knew yet wisely excluded Janet's data lest Estelle's family prevent his publishing the case; (b) that Janet's published data about the youngster's fall reached him through a professional network; and (c) that Janet's plausible addition comports well with his theoretical psychology of action--used in this article to explain the fine-grained parsing of Estelle's inner processes during the milliseconds of her fall: her vehement affect substituted for adaptive behavior. This article deepens the understanding of the Despin-Janet connection; maintains that Janet's addition deserves a place in the tradition of the medical case report; encourages trauma specialists to become familiar with their pioneers; and highlights the clinical continuity from Janet's affirmation of Despine's pioneering treatment strategies with the chronically traumatized to contemporary treatment for the same population, conceptualized along Janetian lines.

  16. Biowaiver monographs for immediate release solid oral dosage forms based on biopharmaceutics classification system (BCS) literature data: verapamil hydrochloride, propranolol hydrochloride, and atenolol.

    Science.gov (United States)

    Vogelpoel, H; Welink, J; Amidon, G L; Junginger, H E; Midha, K K; Möller, H; Olling, M; Shah, V P; Barends, D M

    2004-08-01

    Literature data related to the Biopharmaceutics Classification System (BCS) are presented on verapamil hydrochloride, propranolol hydrochloride, and atenolol in the form of BCS-monographs. Data on the qualitative composition of immediate release (IR) tablets containing these active substances with a Marketing Authorization (MA) in the Netherlands (NL) are also provided; in view of these MA's the assumption was made that these tablets were bioequivalent to the innovator product. The development of a database with BCS-related data is announced by the International Pharmaceutical Federation (FIP).

  17. Dandruff, seborrheic dermatitis, and psoriasis drug products containing coal tar and menthol for over-the-counter human use; amendment to the monograph. Final rule

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-03-15

    The Food and Drug Administration (FDA) is issuing a final rule amending the final monograph (FM) for over-the-counter (OTC) dandruff, seborrheic dermatitis, and psoriasis drug products to include the combination of 1.8 percent coal tar solution and 1.5 percent menthol in a shampoo drug product to control dandruff. FDA did not receive any comments or data in response to its previously proposed rule to include this combination. This final rule is part of FDA's ongoing review of OTC drug products.

  18. RSC Chromatography Monographs Quantitative In Silico Chromatography Computational Modelling of Molecular Interactions.

    Science.gov (United States)

    Hanai, Toshihiko

    2014-07-29

    All early chromatographic techniques, starting from the primitive "ancient" chromatography introduced by Tswett in the very early twentieth century, perfected in partition chromatography in the 1940s by Martin and Synge, and extended to a variety of additional separation mechanisms later, were first entirely experimental trial-and-error methods. The early years can also be characterized by searching for theoretical base of various separation techniques that would allow establishing relation between the structure of the analytes and their chromatographic behavior. The advent of computers followed by development of the new software then revolutionized the theoretical approaches and enabled detailed modeling instead of tedious experimentation. This book introduces the readers to the era of computational modeling in which molecular interactions are used to analyze the mechanisms of general molecular interactions with a special focus on biological applications. This article is protected by copyright. All rights reserved.

  19. Measures of abdominal adiposity and the risk of stroke: the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) study.

    Science.gov (United States)

    Bodenant, Marie; Kuulasmaa, Kari; Wagner, Aline; Kee, Frank; Palmieri, Luigi; Ferrario, Marco M; Montaye, Michèle; Amouyel, Philippe; Dallongeville, Jean

    2011-10-01

    Excess fat accumulates in the subcutaneous and visceral adipose tissue compartments. We tested the hypothesis that indicators of visceral adiposity, namely, waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR), are better predictors of stroke risk than body mass index (BMI). The association of BMI, WC, WHR, and WHtR with stroke was assessed in 31,201 men and 23,516 women, free of vascular disease at baseline, from the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) study. During a mean follow-up of 11 years, 1130 strokes were recorded. Relative risks (95% CI) were calculated by Cox regression after stratification for center and adjustment for age, smoking, educational level, alcohol consumption, hypertension, diabetes, total cholesterol, high-density lipoprotein cholesterol, and BMI and model fit was assessed using log-likelihoods. BMI, WC, WHR, and WHtR were associated with the risk of stroke in men. After full adjustment including BMI, the relative risks for stroke remained significant for WC (1.19 [1.02 to 1.34] per 1 SD increase in WC), WHR (1.14 [1.03 to 1.26]), and WHtR (1.50 [1.28 to 1.77]). Among women, the extent of the associations with stroke risk was similar for WHtR (1.31 [1.04 to 1.65]), WC (1.19 [0.96 to 1.47]), and WHR (1.08 [0.97 to 1.22]). Further analyses by World Health Organization obesity categories showed that WC, WHR, and WHtR were associated with the risk of stroke also in lean men and women (BMI<25 kg/m2), independently of confounders, cardiovascular risk factors, and BMI. Indicators of abdominal adiposity, especially WHtR, are more strongly associated with stroke risk than BMI. These results emphasize the importance of measuring abdominal adiposity, especially in lean subjects.

  20. Patterns and Prevalence of School Access, Transitions and Equity in South Africa: Secondary Analyses of BT20 Large-Scale Data Sources. CREATE Pathways to Access. Research Monograph No. 27

    Science.gov (United States)

    Fleisch, Brahm; Shindler, Jennifer

    2009-01-01

    This monograph looks at patterns and prevalence of initial school enrolment, late entry, attainment promotion, and repetition in urban South Africa. The paper pays special attention to the particular gender nature of the patterns of school participation. The study analyses data generated in the genuine representative cohort study, Birth-to-Twenty…

  1. Rune Frederiksen, Elizabeth R. Gebhard & Alexander Sokolicek (eds., The Architecture of the Ancient Greek Theatre, Monographs of the Danish Institute, Volume 17 (Aarhus: Aarhus University Press and The Danish Institute at Athens, 2015

    Directory of Open Access Journals (Sweden)

    William C. Miller

    2017-03-01

    Full Text Available A review of the book: Rune Frederiksen, Elizabeth R. Gebhard & Alexander Sokolicek (eds., The Architecture of the Ancient Greek Theatre, Monographs of the Danish Institute, Volume 17 (Aarhus: Aarhus University Press and The Danish Institute at Athens, 2015

  2. Unconventional Methods and Materials for Preparing Educational Administrators. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM State-of-the-Knowledge Series, Number Fifteen. UCEA Monograph Series, Number Two.

    Science.gov (United States)

    Wynn, Richard

    In this monograph, the author describes the variety of new and innovative instructional methods and materials being used to prepare educational administrators. Because the subject is new and the nomenclature surrounding it imprecise, the author defines his terms. An outline of the history of unconventional instructional methods and the rationale…

  3. Preparing Educational Leaders: A Review of Recent Literature. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM/ State-of-the-Knowledge Series, Number Fourteen. UCEA Monograph Series, Number One.

    Science.gov (United States)

    Farquhar, Robin H.; Piele, Philip K.

    In this monograph, the authors provide a general overview of recent literature on administrator preparation programs. Ten chapters parallel the major interrelated components of an administrator preparation program: Program content, program structure, recruitment and selection, instructional approaches, field-related experiences, student research,…

  4. Training-in-Common for Educational, Public, and Business Administrators. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM State-of-the-Knowledge Series, Number Seventeen. UCEA Monograph Series, Number Four.

    Science.gov (United States)

    Miklos, Erwin

    In this monograph, the author assesses the progress that has been made toward the development of in-common programs for preparing administrators to serve in a variety of institutional settings. After outlining the assumptions, rationales, and strategies behind attempts to institute interdisciplinary administrator training programs, the author…

  5. Emergent Practices in the Continuing Education of School Administrators. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM State-of-the-Knowledge Series, Number Sixteen. UCEA Monograph Series, Number Three.

    Science.gov (United States)

    Lutz, Frank W.; Ferrante, Reynolds

    In this monograph, the authors describe the shortcomings of traditional approaches to continuing education of administrators and examine the extent to which innovations are being attempted in present practices. The authors note that, in print and in practice, continuing education of administrators has failed to develop to the extent that it can be…

  6. New Approaches to Recruitment and Selection of Educational Administrators. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM State-of-the-Knowledge Series, Number Eighteen. UCEA Monograph Series, Number Five.

    Science.gov (United States)

    Stout, Robert T.

    In this monograph, the author claims there is a need for administrators who are responsive to legitimate demands for educational change. He reviews the shortcomings of contemporary American educational systems and traditional procedures for selecting and preparing administrators -- a group noted for its size and homogeneity. The author contends…

  7. 港口危险化学品项目安全设施设计专篇编制要点分析%Points analysis for compilation of safety facilities designed monographs in port hazardous chemicals project

    Institute of Scientific and Technical Information of China (English)

    韩刚; 龚庆文; 赵秀慧

    2014-01-01

    以天津浮式LNG接收终端项目(一期)码头工程为依托,从安全设施设计专篇的前期准备工作、编制内容及专篇审查各环节进行逐一论述,使设计人员对此类设计专篇的工作有一个全面系统的了解,并为今后危险化学品码头工程安全设施设计专篇的编制提供借鉴。%Taking Tianjin floating LNG receiving terminal project (Phase I) wharf engineering as the basis, we discussed the preparatory work, monographs content and monographs reviewing of safety facilities designed monographs to allow designers to have a comprehensive and systematic understanding of such designs, which can provide a reference for the future work of dan-gerous chemicals wharf engineering safety facilities designed monographs.

  8. Monograph of Chroogomphus (Gomphidiaceae)

    Science.gov (United States)

    Orson K. Miller

    1964-01-01

    The study of the interesting agaric family, Gomphidiaceae, was undertaken in 1958. Since that time collections have been made and examined from Idaho, Washington, Oregon, Montana, and the Upper and Lower Peninsulas of Michigan. Collections from New Hampshire failed to yield any specimens in this genus. All but three of the North American species have been studied from...

  9. Monograph On Tensor Notations

    Science.gov (United States)

    Sirlin, Samuel W.

    1993-01-01

    Eight-page report describes systems of notation used most commonly to represent tensors of various ranks, with emphasis on tensors in Cartesian coordinate systems. Serves as introductory or refresher text for scientists, engineers, and others familiar with basic concepts of coordinate systems, vectors, and partial derivatives. Indicial tensor, vector, dyadic, and matrix notations, and relationships among them described.

  10. Every Monograph a Movie

    Science.gov (United States)

    Poe, Marshall

    2012-01-01

    In this article, the author, based on his own experience, contends that historical videos are engaging--more engaging than history text. As far as he can recall, almost no layperson (that is, a nonacademic) has ever contacted him about his published research. In contrast, "users" of YouTube comment on the historical videos daily. Thousands of…

  11. Yersinia enterocolitica Monographic Study

    OpenAIRE

    2011-01-01

    Germs from Yersinia genus have a vast ecologic niche, being met at different domestic and wild animal species, but also in food, water and soil. The majority of yersinis live in the digestive tract of human and numerous animal species, especially rodents, but also in soil, plant debris, waters etc. Numerous species of Yersinia genus could produce characteristic infections in human, the main source of infections is represented by rodents and hematophagous insects or, more frequently, by water ...

  12. Yersinia enterocolitica Monographic Study

    Directory of Open Access Journals (Sweden)

    Emil Tirziu

    2011-10-01

    Full Text Available Germs from Yersinia genus have a vast ecologic niche, being met at different domestic and wild animal species, but also in food, water and soil. The majority of yersinis live in the digestive tract of human and numerous animal species, especially rodents, but also in soil, plant debris, waters etc. Numerous species of Yersinia genus could produce characteristic infections in human, the main source of infections is represented by rodents and hematophagous insects or, more frequently, by water or contaminated food. In a 1999 study, Mead and coauthors established that the Yersinia enterocolitica prevalence in food, in USA, is around 90%. Foods of animal origin more frequently contaminated with Yersinia enterocolitica are: pork, poultry, beef and lamb meat, milk, ice-cream, sea fruits etc., among them pork meat and milk represents the sources of the most numerous toxi-infection outbreaks in human, in different world regions. Bacteria determine infections which interest the digestive tract in numerous animal species and human, with diarrhea, lymphadenitis, pneumonia and abortion are the most important symptoms. Yersinia enterocolitica enter the human body regularly by oral ingestion, and localize itself with predilection in the distal portion of the ileum and at the ileocaecal appendix and proximal colon level, were determine a terminal ileitis with lymphadenitis, acute enterocolitis, and secondary accompanied with nodosum erythema, poliartritis that could be complicated with septicemia, sometimes leading to death.

  13. Intelligence. Indochina Monographs,

    Science.gov (United States)

    1982-01-01

    literary pieces such as proverbs, folk songs, lyrical poems cad ritual chants. The composition of these songs and poems is simple, -•% the language...governing the composition of folk songs, lyrical poems and ritual chants helped sharpen the Communist propaganda technique to the point that every...Vietnam—United States—Free World intelligence community were great and constant. During this long war the entire intelligence program improved each

  14. Holy Grails and Monographs.

    Science.gov (United States)

    Kline, Lloyd W.

    It appears that there is no clear answer to the question of what people are looking for in their professional literature in reading, since professionals, including publishers, writers, and educators, are individuals with differing needs and opinions. However, settling on an answer may not be important to excellence in education; perhaps only the…

  15. Citation Analysis Shows Promise as an Effective Tool for Monograph Collection Citation Analysis Shows Promise as an Effective Tool for Monograph Collection Development. A Review of: Enger, K. B. (2009. Using citation analysis to develop core book collections in academic libraries. Library & Information Science Research, 31(2, 107‐112.

    Directory of Open Access Journals (Sweden)

    Scott Marsalis

    2010-06-01

    Full Text Available Objective – To test whether acquiring books written by authors of highly cited journal articles is an effective method for building a collection in the social sciences.Design – Comparison Study.Setting – Academic library at a public university in the US.Subjects – A total of 1,359 book titles, selected by traditional means (n=1,267 or based on citation analysis (n=92.Methods – The researchers identified highly‐ranked authors, defined as the most frequently cited authors publishing in journals with an impact factor greater than one, with no more than six journals in any category, using 1999 ISI data. They included authors in the categories Business, Anthropology, Criminology & Penology, Education & Education Research, Political Science, Psychology, Sociology/Anthropology, and General Social Sciences. The Books in Print bibliographic tool was searched to identify monographs published by these authors, and any titles not already owned were purchased. All books in the study were available to patrons by Fall 2005. The researchers collected circulation data in Spring 2007, and used it to compare titles acquired by this method with titles selected by traditional means.Main Results – Overall, books selected by traditional methods circulated more than those selected by citation analysis, with differences significant at the .001 level. However, at the subject category level, there was no significant difference at the .05 level. Most books selected by the test method circulated one to two times.Conclusion – Citation analysis can be an effective method for building a relevant book collection, and may be especially effective for identifying works relevant to a discipline beyond local context.

  16. Book review: Peregruznoe I Burial Ground: Results of Interdisciplinary Research : Monograph [Text] / M. A. Balabanova, E. V. Pererva [at al.]. – Volgograd : Izd-vo Volgogradskogo Filiala FGBOU VPO RANHiGS, 2014. – 360 p.

    Directory of Open Access Journals (Sweden)

    Tairov Aleksandr Dmitrievich

    2016-04-01

    Full Text Available The review concerns the monograph “Peregruznoe I Burial Ground: Results of Interdisciplinary Research. The book was prepared by the team of authors including archaeologists, anthropologists, paleosoil specialists, archaeozoologists. The review contains examination of materials and main conclusions for every chapter of the monograph. The monograph is devoted to the analysis of materials from 52 burial mounds dated from the Aeneolith to the Middle Ages. Most of them were erected in the Sarmatian period. In the review, the controversial points concerning the reconstruction of the paleodemographic and physicalgenetic structure of the buried Sarmatian population were pointed out. The authors consider that the gender disharmony of the Early and Middle Sarmatian samples was determined by the peculiarities of mounds formation of nomadic groups localized at the winter and summer nomad camps. This conclusion provokes some objections. As a positive moment, it should be noted that the authors have discovered new trends by means of analysis of cultural and chronological Sarmatian groups according to anthropological data. The monograph presents new interesting data related to reconstruction of the social structure of the Sarmatian societies, burial mound construction, the taxonomic composition of animals from grave pits and mounds. It is necessary to note, that the authors carried out a great deal of investigation and study. The monograph presents abundant scientific data. Interpretation of this material has a great potential which resources are far from being exhausted. The book is going to be a significant event not only for the study of the Volga-Ural steppe antiquities but for all over the Sarmatian archaeology.

  17. A novel method for the determination of chemical purity and assay of menaquinone-7. Comparison with the methods from the official USP monograph.

    Science.gov (United States)

    Jedynak, Łukasz; Jedynak, Maria; Kossykowska, Magdalena; Zagrodzka, Joanna

    2017-02-20

    An HPLC method with UV detection and separation with the use of a C30 reversed phase analytical column for the determination of chemical purity and assay of menaquinone-7 (MK7) in one chromatographic run was developed. The method is superior to the methods published in the USP Monograph in terms of selectivity, sensitivity and accuracy, as well as time, solvent and sample consumption. The developed methodology was applied to MK7 samples of active pharmaceutical ingredient (API) purity, MK7 samples of lower quality and crude MK7 samples before purification. The comparison of the results revealed that the use of USP methodology could lead to serious overestimation (up to a few percent) of both purity and MK7 assay in menaquinone-7 samples. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Veterinary History Museum in Zagreb - on the occasion of a jubilee monograph on the collection of veterinary instruments of the Zagreb University Faculty of Medicine.

    Science.gov (United States)

    Vucevac Bajt, Vesna

    2010-01-01

    To mark its 90th anniversary, the Faculty of Veterinary Medicine, University of Zagreb, published a book Collection of Veterinary Instruments from the Museum of Veterinary History, which is a significant contribution to the history of veterinary medicine of Croatia. The presented collection is on display in the Museum of Veterinary History at the Faculty of Veterinary Medicine. The Museum, an integral part of the Department of History of Veterinary Medicine, was founded by decree in 1936. It houses several collections: archives, veterinary and related literature, a collection of veterinary instruments, and a collection of horseshoes. The monograph presents the veterinary instruments which were of utmost importance for the development of veterinary science and practice.

  19. Freud's private mini-monograph on his own dreams. A contribution to the celebration of the centenary of The interpretation of dreams.

    Science.gov (United States)

    Blum, H P

    2001-10-01

    A virtually unknown brief commentary by Freud on the characteristics of his own dreams is described and discussed. Freud's mini-monograph, discovered after some 80 years, has autobiographical, theoretical and organisational significance in the enigmatic context of the early development of psychoanalysis. Found among papers of Alfred Adler, this extraordinary document adds to our knowledge of psychoanalytic history, including the significance of dreams in the evolution of psychoanalytic thought. Freud's commentary permitted the identification of a particular dream as his own. This dream had been presented in anonymity to the fledgling Vienna Psychoanalytic Society for interpretation. The dream was later inserted, again anonymously, into The Interpretation of Dreams with Freud's own remarkable pre-oedipal interpretation. Freud's conflicted relationships with Adler and Jung are considered in historical context.

  20. Redesigning the practice model for general internal medicine. A proposal for coordinated care: a policy monograph of the Society of General Internal Medicine.

    Science.gov (United States)

    2007-03-01

    General Internal Medicine (GIM) faces a burgeoning crisis in the United States, while patients with chronic illness confront a disintegrating health care system. Reimbursement that rewards using procedures and devices rather than thoughtful examination and management, plus onerous administrative burdens, are prompting physicians to pursue specialties other than GIM. This monograph promotes 9 principles supporting the concept of Coordinated Care--a strategy to sustain quality and enhance the attractiveness and viability of care delivered by highly trained General Internists who specialize in the longitudinal care of adult patients with acute and chronic illness. This approach supplements and extends the concept of the Advanced Medical Home set forth by the American College of Physicians. Specific components of Coordinated Care include clinical support, information management, and access and scheduling. Success of the model will require changes in the payment system that fairly reimburse physicians who provide leadership to teams that deliver high quality, coordinated care.

  1. RDA描述的不同:以普通图书为例%Differences of RDA Cataloging: Focus on Monograph

    Institute of Scientific and Technical Information of China (English)

    王忠红

    2012-01-01

    以普通图书为重点,论述RDA著录的不同。文章先概述RDA基本理念和条例组织,然后以著录项目为序,逐项说明其不同之处,包括著录信息来源、著录方式以及检索点的获取。稍议RDA的利弊以及对编目馆员工作和OPAC的影响。%This paper discusses differences of RDA cataloging from AACR2 with a focus on monograph. It first discusses the RDA rules, and then the differences in description areas. It covers differences in sources of information, transcription and choosing of access points. In the end, discusses its impact on the cataloging work and OPAC, and makes a conclusion.

  2. 清代中前期饮食专著的编撰研究%On the Diet Monographs of the Early and Middle Qing Dynasty

    Institute of Scientific and Technical Information of China (English)

    孙铁楠

    2012-01-01

    饮食是人类赖以生存发展的重要因素。如何解决好饮食问题,涉及到社会的政治、经济、文化等多方面的内容。我国很早就有关于饮食方面的书籍,清代中前期饮食文献是我国古代饮食文献发展的最高阶段,它不仅对前代饮食进行了总结,使饮食文献内容更加丰富,而且对近现代饮食文献的发展和完善也产生积极的作用。在数目众多的清代饮食文献中,饮食专著文献不仅是清代饮食文献的主体,而且最能体现这一时期所取得的成就。目前学术界对于清代中前期饮食专著文献的研究是比较薄弱的。专门对清代中前期饮食文献方面的研究,虽然有对于某一本著作进行研究的论文,但是缺少从总体上进行分析探讨。因此,从历史文献学角度研究清代中前期饮食专著文献是十分必要的。%Diet is an important factor in the survival and development of human beings. How to have a healthy diet involves many aspects including politics, economy, and culture. China had books on diet quite long time ago. The early and middle period of Qing Dynasty reached the highest stage of development of China's ancient diet literature, which not only summarized the previous generations' diet literature, but also enriched their contents and had a positive effect on the development of modern diet literature. Diet monographs account for a crucial part among the numerous culinary literatures in Qing Dynasty, and they can best embody the achievements of this period. However, the study of diet monographs of the early and middle period of Qing Dynasty is relatively weak. Although there are papers researching on some of those monographs, overall analysis and discussion are insufficient. Therefore, it is very necessary to study the diet monographs of the early and middle period of Qing Dynasty from the point of historical literature view.

  3. 浅议海洋科技专著中地图的规范化%Map Standardization in Marine Technology Monograph

    Institute of Scientific and Technical Information of China (English)

    白燕; 彭珺

    2014-01-01

    The existing problems of maps are discussed and analyzed. It is believed that maps should meet the requirements of self -evident, abstract and simplistic. As for the map name, line graphs, and image maps, the suggestions of map standardization are proposed to improve maps' information transfer functions and visual effects in marine technology monographs.%讨论分析了目前海洋科技专著中地图所存在的问题,提出了地图应符合自明性、抽象性和简明性的要求,并针对图名、线划图和影像图提出地图制作的规范化建议,以便增强地图在海洋科技专著中的信息传递功能和视觉效果。

  4. [Knowledge of German neurologists on migraine around 1890. Paul Julius Möbius and his 1894 monograph Die Migräne].

    Science.gov (United States)

    Schobeß, C; Steinberg, H

    2013-08-01

    Paul Julius Möbius (1853-1907), a Leipzig-based author and editor on a vast majority of subjects, has often been acknowledged as a leading 19th-century German neurologist. His impact on the development of knowledge on migraine has likewise been pointed to. This study compares the monograph published by Möbius on the illness in 1894 with contemporary publications and with present day best practice to establish if the author really made an essential contribution to the problem of migraine. As a representative of the central theory Möbius assumed that migraine was caused by aberrations in the brain. At the same time he made it clear that due to very limited diagnostic options this was only a hypothesis. Apart from a genetic factor and these cerebral changes, for Möbius the general state of health was a decisive factor and prevention and change in lifestyle therefore played a crucial role in his therapeutic recommendations. Basically there were only few differences between the views of Möbius and his colleagues, the major dissimilarity being that Möbius postulated a merely suggestive impact but no physical effect of electrotherapy. Although Möbius's monograph on migraine lacks originality, it provides a concise, easy to understand and stylistically impressive overview on the state of knowledge at that time. Therefore, the book can be considered as a benchmark publication of German speaking neurology around 1890 on migraine and it is highly recommended to present day headache and migraine researchers as well as historians of psychiatry and neurology.

  5. Review for the volume Alexei Marco. The destiny of a jeweler from Moldova, by Liliana Condraticova, work about the monographic study of the artist jeweler Alexei Marco, within Moldovan cultural space

    Directory of Open Access Journals (Sweden)

    Ana CARAS

    2012-06-01

    Full Text Available The present paper represents the review for the volume Alexei Marco. The destiny of a jeweler from Moldova, by Liliana Condraticova, published at Lumen Publishing House, a volume about the monographic study of an artist jeweler from Moldova. The work comes as a novelty element in the cultural context of Moldova. The lack of studies regarding the life and work of the masters of jewelry manufacturing, determined the author to develop a work in order to provide relevant, comprehensive information, in terms of the artistic creation of the most famous jeweler in Moldova – Alexei Marco. The study uses monographic method, a method used particularly in empirical research, which involves direct observation of territorial social unit without the use of sampling and without manipulating variables. The social reality investigated is approached in all its manifestations.

  6. Russian Expatriate Community in A.V. Antoshin’s Monograph “Russian Emigrants in Terms of “Cold War” (Middle 1940s – Middle 1960s”: Establishment, Political Activity, Relation with the USSR

    Directory of Open Access Journals (Sweden)

    Artem I. Kuritsyn

    2013-01-01

    Full Text Available The review considers A.V. Antoshin’s monograph “Russian Emigrants in Terms of “Cold War” (Middle 1940s – Middle 1960s”. Special attention is attached to the problem, concerned with the second wave of emigration. The article analyses the process of Soviet citizens repatriation after the World War II, considers the issues, concerned with the political activities of Russian expatriate community, propaganda efforts of People’s Labor Union and other emigration organizations.

  7. 运用专题导向学习进行小论文写作课程之成效探讨%The Study to Explore the Effect of the Curriculum of Essay Writing in Monograph-oriented Learning

    Institute of Scientific and Technical Information of China (English)

    张碧如; 姚湘玲; 吕秋萍

    2011-01-01

    台湾技职教育新课程的规划中,将"专题制作"纳入校定必修课程,本研究旨在探讨运用专题导向学习,利用数字学习平台以专题制作课程结合小论文写作之学习成效。研究发现专题导向学习的教学活动受到大部分学生的喜爱与欢迎,并认为可以增进认知、情意、技能及小论文写作等的能力,故专题导向学习值得在教学中推广。在专题制作课程实施过程中也发现,学习过程中提供学生合作解决问题的机会,培养使用资料搜集的技能,对于提升学生的专题相关知识及网络的使用能力等都具有正向的效果。%In the new curriculum of technical and vocational education in Taiwan,monograph has been subsumed both required and important subject to train the students to have autonomy and the ability of integration.Further,with the progress and development of computer technology,the students had rich and diverse learning situations,so this study was to investigate the learning effect of applying monograph-oriented learning which combined project making course and essay writing on e-learning platform.The results of this study showed that monograph-oriented teaching was very popular with most of the students,and they thought that it could improve cognition,affection,ability and writing ability on essay.Therefore,monograph-oriented teaching is worth promoting in teaching.We also found that the teaching not only offered the students chances of solving problem cooperatively and developing the ability of collecting information but upgraded the knowledge about the monograph,and the ability of Internet using positively.

  8. The impact of the EMA change in definition of "dose" on the BCS dose-solubility ratio: a review of the biowaiver monographs.

    Science.gov (United States)

    Sediq, Ahmad; Kubbinga, Marlies; Langguth, Peter; Dressman, Jennifer

    2014-01-01

    The Biopharmaceutics Classification System (BCS) defines the solubility characteristics of an active pharmaceutical substance based on its dose-solubility ratio: for highly soluble drugs this ratio is less than 250 mL over a defined pH range. Prior to the revision of the European Medicines Agency (EMA, formerly EMEA) guideline in 2010, the "dose" in this ratio was consistently defined by the US FDA, the EMA, and the WHO biowaiver guidelines as the highest dosage strength. However, in the revised EMA guideline, the dose is defined as the highest single dose administered according to the Summary of Product Characteristics. The new EMA criterion for highly soluble may be closer to the actual conditions of use, but it is not in line with the dose that would be used in the in vivo bioequivalence study. This paper evaluates the impact on the BCS classification of the active pharmaceutical ingredients of the published biowaiver monographs and discusses the consequences of the possible change in classification on biowaiver recommendations. Using the current definition of dose by the EMA, the biowaiver recommendations for metoclopramide hydrochloride and verapamil hydrochloride are no longer valid according to EMA criteria. For prednisolone and prednisone, a reevaluation of the biowaiver recommendation, taking into account the usual dosing levels, seems appropriate.

  9. The use of community herbal monographs to facilitate registrations and authorisations of herbal medicinal products in the European Union 2004-2012.

    Science.gov (United States)

    Peschel, Wieland

    2014-12-02

    The provisions for the simplified registration of traditional herbal medicinal products in the European Union were introduced by Directive 2004/24/EC amending Directive 2001/83/EC (Chapter 2a) in 2004. Since implementation in the European member states until December 2012 a total of 1015 registrations (traditional use) and 514 authorisations (well-established use) have been granted for products containing substances/ preparations from about 200 different herbal drugs. The overall number of received applications with more than one third still under assessment suggests a further increase for the next years. This review summarises the main features of registered and authorised herbal medicinal products in the EU and evaluates available data against provisions of Directive 2004/24/EC and European standards established by the Committee on Herbal Medicinal Products at the European Medicines Agency. The supportive function of Community herbal monographs is described as regards availability and their use in national procedures, which is complemented by an analysis of specific future challenges from experiences made with the implementation of Directive 2004/24/EC so far.

  10. Heparin sodium compliance to the new proposed USP monograph: elucidation of a minor structural modification responsible for a process dependent 2.10 ppm NMR signal.

    Science.gov (United States)

    Mourier, Pierre A J; Guichard, Olivier Y; Herman, Fréderic; Viskov, Christian

    2011-01-25

    Heparin is a highly sulfated hetero polysaccharide mixture found and extracted from mammalian tissues. It has been widely used as an anticoagulant drug during the past decades. In the new proposed USP heparin monograph, the ¹H NMR acceptance criteria to prevent contamination by over sulfated chondroitin sulfate (OSCS), or other persulfated glycosaminoglycans, specifies that no unidentified signals greater than 4% of the mean of signal height of 1 and 2 should be present in the following ranges: 0.10-2.00, 2.10-3.20, and 5.70-8.00 ppm. However, those criteria do not take into account the impact of potential structural modifications generated by the heparin manufacturing processes. In fact, starting from pig mucosa, heparin purification involves oxidizing reagents such as sodium peroxide, potassium permanganate and peracetic acid. In the present work, we demonstrate that potassium permanganate treated heparins show a small but characteristic extra signal at 2.10 ppm. Controlled heparinase I depolymerisation is used to target and excise the oligosaccharide responsible for this extra signal from the polysaccharide backbone. By using orthogonal chromatographic techniques, the fingerprint oligosaccharide was isolated and its structure elucidated. Without the identification of this structural moiety, such purified heparins may have been considered as non-compliant drug substance and not suitable for pharmaceutical use. Copyright © 2010 Elsevier B.V. All rights reserved.

  11. A reexamination of the North American Crepis agamic complex and comparison with the findings of Babcock and Stebbins' classic biosystematic monograph.

    Science.gov (United States)

    Sears, Christopher J; Whitton, Jeannette

    2016-07-01

    Babcock and Stebbins coined the term agamic complex in their 1938 monograph of the North American Crepis agamic complex. Despite the historical role that this complex holds in the evolutionary literature, it has not been reexamined in over 75 years. We present a thorough reevaluation of the complex to test hypotheses proposed by Babcock and Stebbins about its origins and spread, the relationships of diploids, and the nature and origins of polyploids. We used flow cytometry to infer ploidy of roughly 600 samples spanning the morphological and taxonomic diversity of the complex and a phylogenetic analysis of plastid DNA variation to infer maternal relationships among diploids and to infer maternal origins of polyploids. We identified populations of all seven recognized diploids plus one new lineage. Phylogenetic analysis of plastid DNA variation in diploids revealed a well-resolved, but moderately supported phylogeny, with evidence for monophyly of the North America Crepis agamic complex and no evidence of widespread homoploid hybridization. Polyploids showed evidence of multiple origins and a pattern of frequent local co-occurrence consistent with repeated colonization of suitable sites. Our findings agree broadly with the distribution and variation of ploidy within and among species described by Babcock and Stebbins. One key difference is finding support for monophyly of North American species, and refuting their hypothesis of polyphyly. Our results provide an explicit phylogenetic framework for further study of this classic agamic complex. © 2016 Botanical Society of America.

  12. Cardiovascular screening in adolescents and young adults: a prospective study comparing the Pre-participation Physical Evaluation Monograph 4th Edition and ECG.

    Science.gov (United States)

    Fudge, Jessie; Harmon, Kimberly G; Owens, David S; Prutkin, Jordan M; Salerno, Jack C; Asif, Irfan M; Haruta, Alison; Pelto, Hank; Rao, Ashwin L; Toresdahl, Brett G; Drezner, Jonathan A

    2014-08-01

    This study compares the accuracy of cardiovascular screening in active adolescents and young adults using a standardised history, physical examination and resting 12-lead ECG. Participants were prospectively screened using a standardised questionnaire based on the Pre-participation Physical Evaluation Monograph 4th Edition (PPE-4), physical examination and ECG interpreted using modern standards. Participants with abnormal findings had focused echocardiography and further evaluation. Primary outcomes included disorders associated with sudden cardiac arrest (SCA). From September 2010 to July 2011, 1339 participants underwent screening: age 13-24 (mean 16) years, 49% male, 68% Caucasian, 17% African-American and 1071 (80%) participating in organised sports. Abnormal history responses were reported on 916 (68%) questionnaires. After physician review, 495/916 (54%) participants with positive questionnaires were thought to have non-cardiac symptoms and/or a benign family history and did not warrant additional evaluation. Physical examination was abnormal in 124 (9.3%) participants, and 72 (5.4%) had ECG abnormalities. Echocardiograms were performed in 586 (44%) participants for abnormal history (31%), physical examination (8%) or ECG (5%). Five participants (0.4%) were identified with a disorder associated with SCA, all with ECG-detected Wolff-Parkinson-White. The false-positive rates for history, physical examination and ECG were 31.3%, 9.3% and 5%, respectively. A standardised history and physical examination using the PPE-4 yields a high false-positive rate in a young active population with limited sensitivity to identify those at risk for SCA. ECG screening has a low false-positive rate using modern interpretation standards and improves detection of primary electrical disease at risk of SCA. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  13. Impact of age on the importance of systolic and diastolic blood pressures for stroke risk: the MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project.

    Science.gov (United States)

    Vishram, Julie K K; Borglykke, Anders; Andreasen, Anne H; Jeppesen, Jørgen; Ibsen, Hans; Jørgensen, Torben; Broda, Grazyna; Palmieri, Luigi; Giampaoli, Simona; Donfrancesco, Chiara; Kee, Frank; Mancia, Giuseppe; Cesana, Giancarlo; Kuulasmaa, Kari; Sans, Susana; Olsen, Michael H

    2012-11-01

    This study investigates age-related shifts in the relative importance of systolic (SBP) and diastolic (DBP) blood pressures as predictors of stroke and whether these relations are influenced by other cardiovascular risk factors. Using 34 European cohorts from the MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project with baseline between 1982 and 1997, 68 551 subjects aged 19 to 78 years, without cardiovascular disease and not receiving antihypertensive treatment, were included. During a mean of 13.2 years of follow-up, stroke incidence was 2.8%. Stroke risk was analyzed using hazard ratios per 10-mm Hg/5-mm Hg increase in SBP/DBP by multivariate-adjusted Cox regressions, including SBP and DBP simultaneously. Because of nonlinearity, DBP was analyzed separately for DBP ≥ 71 mm Hg and DBP <71 mm Hg. Stroke risk was associated positively with SBP and DBP ≥ 71 mm Hg (SBP/DBP ≥ 71 mm Hg; hazard ratios: 1.15/1.06 [95% CI: 1.12-1.18/1.03-1.09]) and negatively with DBP <71 mm Hg (0.88[0.79-0.98]). The hazard ratio for DBP decreased with age (P<0.001) and was not influenced by other cardiovascular risk factors. Taking into account the age × DBP interaction, both SBP and DBP ≥ 71 mm Hg were significantly associated with stroke risk until age 62 years, but in subjects older than 46 years the superiority of SBP for stroke risk exceeded that of DBP ≥ 71 mm Hg and remained significant until age 78 years. DBP <71 mm Hg became significant at age 50 years with an inverse relation to stroke risk. In Europeans, stroke risk should be assessed by both SBP and DBP until age 62 years with increased focus on SBP from age 47 years. From age 62 years, emphasis should be on SBP without neglecting the potential harm of very low DBP.

  14. Review of the monograph “Corruption: nature, revelation, interaction” / editor-in-chief Academician of the Russian Academy of Sciences T. Ya. Khabrieva. Мoscow: “Yurisprudentsiya” Publishers, 2014, 688 p.

    Directory of Open Access Journals (Sweden)

    Sergey F. Milyukov

    2016-03-01

    Full Text Available The review presents the authorsrsquo opinion of the monograph ldquoCorruption nature revelation interactionrdquo editorinchief Academician of the Russian Academy of Sciences T. Ya. Khabrieva. Selected chapters and paragraphs are reviewed and analyzed. The authors note both positive and negative sides of the monograph. The concept of corruption as a social phenomenon is discussed as well as the need to implement international norms in national legislation the legal framework for combating corruption in Russia the activities of the various institutions to fight against corruption combating corruption in state and municipal service ways of overcoming the corruption potential of legal acts impact of corruption on business and methods of combating corruption abroad. The team of authors including a large number of wellknown scientists and politicians S. B. Ivanov S. B. Naryshkin S. V. Stepashin Yu. A. Tikhomirov A. V. Fedorov T. Ya. Khabrieva etc. view corruption as a social phenomenon highlight the issues of international cooperation on corruption issues give a detailed review of legislation including international on combating corruption and name individual institutions to counteract this dangerous phenomenon. Special chapters are devoted to corruption in the system of state and municipal service and corruption in the business sector. Detailed attention in a separate chapter is given to the institution of anticorruption expertise. nbsp

  15. On the Construction of Monographic Teaching Mode of College Chinese Course from the View of Culture%文化视野下的大学语文专题教学模式建构

    Institute of Scientific and Technical Information of China (English)

    杨云萍; 李媛

    2015-01-01

    The monographic teaching becomes the new trend in the reform of College Chinese teaching. There are four characteristics in the monographic teaching mode from the cultural view. Firstly, the teaching aims are inher-iting and innovating the traditional Chinese culture. Secondly, textbook compiling is problem-oriented. Thirdly, it advocates deliberative teaching methods. Lastly, it emphasizes that teachers’role should be organizer and guide in class, instead of the master. This mode embodies the student-oriented teaching idea with attention to cultural function of classroom.%专题教学在大学语文教学改革中成为了一种新的趋势。文化视野下的专题教学模式具有四大特点:以传承与创新中国传统文化为教学目标;以问题为导向编排教材;倡导研讨式课堂教学模式,强调教师的角色由课堂的主宰者转变为课堂的组织者和引导者。这一模式体现了以学生为本、重视课程的文化功能的教学理念。

  16. 针灸学治疗各论教学中运用 SP 的教学设计的探讨%Discussion on the use of SP instructional design in acupuncture and moxibustion treatment of the monograph treating

    Institute of Scientific and Technical Information of China (English)

    蔡兴慧; 胡玲; 唐巍; 张庆萍; 刘广霞; 王欣

    2012-01-01

      Individual monograph in treatment was an important constituent part of the science of acupuncture and moxibustion. In this paper, teaching design that SP should applied in the individual monograph of the science of acupuncture and moxibustion was suggested, which could strengthen the experience of acupuncture and moxibustion. The practice ability and syndrome differentiation thoughts of the students were enhanced by getting in touch with Standardized patients. The teaching quality was expected to increase.%  针灸学治疗各论是针灸学课程的重要组成部分,文章结合教学实践,拟在非针灸专业学生针灸学各论教学中运用SP 的教学设计,加强学生对针灸诊疗过程的体验,通过与标准化病人的接触,加强学生的实践动手能力和中医辨证思维,期望能提高针灸学的教学质量。

  17. 从源数据的类号分歧看总论和专论原则的实践运用%Practical Use of Principles of the General and Monograph from the View of Class Differences of the Source Data

    Institute of Scientific and Technical Information of China (English)

    张立新

    2012-01-01

    总论和专论的分类原则,即能分入专论的文献不分入总论,能分入具体问题、事物的类目则不分入总论性或理论方法性类目。遵循该原则进行分类能够避免类号分歧。总论与专论通常是相互依存的相对概念,没有绝对的总论,也没有绝对的专论。%Classification principles of the general and monograph is that literatures could be divided into the monograph regardless of the general, specific problems could be divided into categories of things regardless of into the general or theoretical method categories. Following these classification principles, we could avoid differences of class number. The general and monographs are usually interdependent relative concept, there is no absolute general, also no absolute monograph.

  18. Preface to the second monograph

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2004-05-01

    Full Text Available 5,00,000 people all over the globe are reported to die of suicide every year. 1,00,000(20% of them are Indians.Suicides are under-reported by 20-100%. Which means it is more likely 8,00,000 people all over and 1,60,000 in India must be dying of suicide every year (taking mean of 20-100% reporting i.e. 60%.Attempted suicides are ten times this figure. This means 8 million all over the globe and 1.6 million in India attempt suicide every year.We know how much burden is placed on care-givers and health-care de­livery systems when a suicidal attempt is made, besides ofcourse its psychoso­cial sequelae.Suicides and attempted suicides are reaching epidemic proportions and hence qualify to be made the focus of public health policy in India and abroad.98% of suicidal deaths have a psychiatric disorder. Therefore better and more affordable psychiatric care is the first important step in suicide eradica­tion. Depression is one psychiatric disorder where suicidal threat is the great­est. Hence specialised Centers to treat Depression, like there are Heart Insti­tutes, are the need for the hour.Suicide is also found more in the widowed, single or divorced, those with alcohol or drug abuse, those with chronic physical and mental illness, and those living alone or in lodging homes. The key factor is social isolation. Hence meth­ods to reduce social isolation are the second important step in reducing suicide rates.Social disintegration is another notable factor responsible for the rise in suicides rates in societies. For example, Lithuania reported the world's highest suicide rates following collapse of the former Soviet Union. Similarly suicides are more common in migrants and changing populations, who experience so­cial disintegration (along with social isolation.Hence to make society suicide-free, a three pronged attack is necessary:Reduce Social Isolation.Prevent Social Disintegration.Treat Mental Disorder.Moreover,the attack will have to be mounted on a war-footing. The need is to first of all identify suicide prevention as public health policy. Just as we think in terms of malaria or polio eradication, or have achieved smallpox eradication, we need to work towards suicide eradication. Just as we have got sensi­tized to the AIDS epidemic, we also need to be aware of the suicide epidemic raging all around us.If that appears farfetched, just remember that man landing on the moon, wireless communication, digital mobile communication technology, and the internet were all farfetched ideas once upon a time.The need is to become aware of the problem, not get overwhelmed by the enormity of the task, and plan concrete steps towards achieving the goal of making society suicide free.

  19. Questions That This Monograph Raises

    Directory of Open Access Journals (Sweden)

    Editors

    2007-01-01

    Full Text Available What is the ideal combination of increased investment in biomedical research by sponsors with least conflict of interest in researchers?What should interested parties do to refurbish pharma's image?Is a voluntary moratorium on pharma spending practically possible?How to resolve the basic schism between profit driven industry and welfare driven profession of medicine?How can CPGs be salvaged from ulterior influence?Can guidelines on guidelines help?Is cost-effectiveness of CPGs a practical solution?Is it possible to grade therapies as Most, Moderate and Least Cost Effective?How can Disease specific Foundations be salvaged from sponsor's influence?How can Journals ensure scientific integrity of conflicted authors and nullify untoward influence of sponsors?Are reports like the Task Force on individual and institutional conflicts of interest of the AAMC followed more in their breach?Are the revised ICMJE guidelines adequate to stub conflicted research?Editorials make pious announcements. Do they really influence what researchers do?How do we protect the interests of human research subjects?Do Best Practice Guidelines and Good Publication Practices really help?Marketability is the name of the game, not usefulness. How do we ensure the latter, even as the former is forwarded?How can we ensure effective traditional therapies remain in use even as new ones are forwarded?How do we ensure non-pharmacological therapies are also forwarded?How can the legitimate thrust of biological psychiatry be encouraged while also forwarding non-pharmacological approaches in psychiatry?What can be done so pharma just cannot consider questionable means as an attractive alternative?How do we expedite scientific self-correction while causing least harm to patients and research subjects?

  20. Drug monographs: afatinib and obinutuzumab.

    Science.gov (United States)

    Mancheril, Benjamin G; Aubrey Waddell, J; Solimando, Dominic A

    2014-03-01

    The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Boulevard #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast.net or J. Aubrey Waddell, Professor, University of Tennessee College of Pharmacy; Oncology Pharmacist, Pharmacy Department, Blount Memorial Hospital, 907 E. Lamar Alexander Parkway, Maryville, TN 37804, e-mail: waddfour@charter.net.

  1. Drug Monographs: Olaratumab and Rucaparib.

    Science.gov (United States)

    Solimando, Dominic A; Waddell, J Aubrey

    2017-04-01

    The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast.net; or J. Aubrey Waddell, Professor, University of Tennessee College of Pharmacy; Oncology Pharmacist, Pharmacy Department, Blount Memorial Hospital, 907 E. Lamar Alexander Parkway, Maryville, TN 37804, e-mail: waddfour@charter.net. The information presented in this review is based on published data and clinical expertise and includes information not included in the product labeling. Incorporation of such published data provides a more robust assessment of the drugs and assists pharmacists in evaluation of orders for off-label use of these agents.

  2. Review of a monograph by P. N. Panchenko «State-legal regularities in the history and theory of state and law and criminal law». Moscow: «Jurisprudence» Publishers, 2014. 518 p.

    Directory of Open Access Journals (Sweden)

    Gennadiy N. Gorshenkov

    2015-12-01

    Full Text Available The article analyzes the problem of legislation imperfection in the sphere of normative legal acts adoption as it is studied in the reviewed monograph. The imperfection consists of ignoring the state and legal regularities. The author39s position is discussed that the normativelegal acts should meet not the legislatorsrsquo ambitions but the legitimate interests of citizens and the state. The author emphasizes the practical benefit of those legal measures that are proposed to stabilize the economy. The idea is developed of creating a general theory of crime and the author39s attitude to modern criminology. The author39s attempt is assessed to adjust the criminal law for the strategic challenges facing Russia in different spheres of life. nbsp

  3. 中国"三计学"领域学术著作引文分析(1987-2010)%Citation Analysis of Chinese Monographs in Scientometrics, Informetrics and Bibliometrics (1987~2010)

    Institute of Scientific and Technical Information of China (English)

    杨洋; 袁军鹏; 潘云涛; 武夷山

    2012-01-01

    For the lack of database, the citation analysis of monographs is rare. But as a major means of dissemination of knowledge, monographs also have numerous citations, which is more standardized and systematic. This paper study on Chinese monographs in Scientometrics, Informetrics and Bibliometrics (1987 ~ 2010), using metrology and statistics methods to analysis the total number, type and language and time distribution of the citation. By statistics we found the increase by year in the number of books and rapid growth of per book citations in near ten years. Most of the authors are male from colleges or universities and the proportion of co-author is 16.7%. The citation analysis results show that monographs cite papers most. Foreign literature also takes a large part. The distribution of citations fits the characteristics of the subject' s development.%目前的引文分析多以期刊论文作为分析的对象.学术著作作为科学知识积累与传播的重要载体(或途径),参考文献数量较多,而且比较规范和系统,对其引文的研究具有重要意义.目前,由于缺乏学术著作的参考文献数据库,针对学术著作的引文分析研究较少.本文以1987~2010年的中国"三计学"领域的学术著作为研究对象,利用科学计量学方法分析这些学术著作的参考文献(引文)的数量、引文的类型、引文语种以及引文年代等的分布情况,将引文分析的对象拓展到学术著作层面.统计表明,此领域著作数量呈增多趋势,近十年本均引文量增长迅速;作者中男性比例较大,多来自高校,合著比例占16.7%.引文分析结果显示,期刊论文在各著作引文类型中占有较大比重,科技期刊为本领域学术著作最主要的信息源;外文文献引用情况较为普遍且比例较高,引文年代分布与学科发展特点相符.

  4. An Innovative Monograph: Comment on "A Study on Wen Yiduo" by Li Leping%一本具有新意的专著——评李乐平的《闻一多论稿》

    Institute of Scientific and Technical Information of China (English)

    陈国恩

    2011-01-01

    “A Study on Wen Yiduo”, is a monographic study on Wen Yiduo's Literary theory, poetry writing and his pursuit of poetic beauty. It has the following features: first, the study shows great concerned about the results of previous studies by focusing on the academic history so as to have informative feature; Second, the method of dialectical thinking is used based on existing research achievement to find new areas of cross-zone or edge discovering and studying new problems; Third, the disciplinary boundaries are broken up to explore ancient and modem contact from his ideological transformation. This monograph implements the spirit of innovation, making a valuable exploration concepts and methods of thought. On some issues, people's understanding of Wen Yiduo is deepened.%,就闻一多的文艺思想、新诗创作和诗美追求等方面进行了专题研究.其特色,一是关注前人研究成果,着力于学术史的清理,资料丰富;二是遵循辩证思维的方法,在现有研究成果的基础上寻找新的交叉地带或边缘领域,发现和研究新的问题;三是打通学科分界,从古今联系中探讨闻一多的思想转变.这本专著贯彻了创新精神,在思想观念和研究方法上做了可贵的探索,在一些问题上把人们对闻一多的认识深化了.

  5. Investigation on several monographs of the Tang dynasty related to Lingnan (Southern Tidges) medicine%唐代几部有关岭南医药专著的考察

    Institute of Scientific and Technical Information of China (English)

    靳士英; 靳朴

    2008-01-01

    、、共著录8部唐代有关岭南的医药专著,至元、明时全佚.今桂林南溪山有宋人摩崖石刻一通;中有、各一条,是唐人郑景岫迄今仅有的遗存.唐代有关南药、海药的专著,有未著撰人的和李珣,李时珍认为两者为一书.今查发现,有一药引一书者,有一药同时引两书者,内容不同,疑为两书.%In the Tang dynasty,eight monographs related to Lingnan medicine were recorded in Yi wen zhi (Bibliography of Arts and Literature) of Xin tang shu (Annals of New Tang Dynasty),Yi wen liie (Brief Bibliography of Arts had Literature) of Tong zhi liie(Brief Annals of General History),Yi wen zhi (Bibliography of Arts and Literature) of Song shi (Annals of Song Dynasty).However,all of them were lost in the Yuan and Ming dynasty.Now,a piece of stone-carving,Gnang nan she sheng lun yang qi tang fang (Nourishing Qi Prescription of Treatise of Keeping Health of Guangnan) was found at the cliff on Nanxi Mountain in Guilin,the descriptions about keeping health prescription and keeping health treatise in Ling nan wei sheng fang (Hygiene Prescriptions of Southern Ridges) were regarded as the only extant version of Guang nan she sheng lun (Treatise of Keeping Health of Guangnan) written by Zheng Jing-xiu in the Tang Dynasty.Monographs about southern Chinese medicines and oversea medicines in the Tang dynasty can be seen,such as Nan hai yao pu (Prescriptions of Nanhai) written by anonymous author and Li Xun's Hai yao ben cao (Oversea Materia Medica).Both claimed by Li Shi-zhen to be the same book.Now,after checking the Zheng he ben cao (Materia Medica of Zhenghe Reign),it is suspicious that these are two different books instead of one,because sometimes,one medicinal item is quoted from one source,while other item can be quoted from the both sourees at the same time with different contexts.

  6. Music and Emotion. Review of "Music and Emotion", monographic issue of the journal «Music Analysis», edited by Michael Spitzer, n. 29/1-2-3 (2010

    Directory of Open Access Journals (Sweden)

    Mario Baroni

    2014-03-01

    Full Text Available The last fifteen years have seen the development of a lively interest, on an international scale, in the topic of emotion in music, documented by numerous noteworthy publications: the two volumes edited by Juslin and Sloboda [2001; 2010], the monographic issues of the journal «Musicae Scientiae» published in 2001 and 2011, and many other texts published in various parts of the world. The topic is not without repercussions also for those involved in musical analysis; and it is no mere chance that the English journal «Music Analysis» chose to dedicate the volume we are now reviewing to the subject. The contributions contained in the volume derive from an international meeting held in Durham in September 2009 and offer a fairly lively cross-section of a wide series of questions. Our only regret is that with the exception of three nordic names (Juslin, Lindström and Eerola, whose place is now solidly established in English language publications all the authors come from the now almost self-referential context of British or American research. But of course this is nothing new.

  7. 民国新闻教育先行者柏德逊和《中国新闻业》探析%Pioneer in Journalism Study: Don D. Journalism Patterson and His monograph The of China

    Institute of Scientific and Technical Information of China (English)

    邓绍根

    2011-01-01

    In 1919, Don D. Patterson, a graduate from Missouri School of'Journalism, came to Shanghai, China. He founded the first Journalism major in St. John University, beeoming the precursor in Chinese journalism education. In December 1922, he published the monograph The Journalism of China, which surveys broadly on the history and status quo of China's journalistic development. This book is a milestone in the studies of China's journalism history.%1919年,密苏里新闻学院毕业生柏德逊来到上海后,创办起中国第一个新闻专业——圣约翰大学报学专业,成为中国新闻教育的先行者。1922年12月,他出版中国新闻史英文著作《中国新闻业》,比较全面地介绍了中国新闻业的发展历史和现状,在中国新闻学术史上具有重要的学术价值和占有重要的历史地位。

  8. 把握学术发展脉搏打造科技专著精品--以上海交通大学出版社医学专著的策划出版为例%Feeling the Pulse of Academic Development and Making Excellent Science and Technology Monographs---Illustrated by the Case of Planning and Publishing of Medical Monographs in Shanghai Jiao Tong University Press

    Institute of Scientific and Technical Information of China (English)

    金宏滨

    2016-01-01

    本文着重介绍了策划选题前期准备过程中,通过经常参加学术会议等多角度多渠道学习,把握学术发展的前沿。同时,作者分享了利用这些方法、渠道策划实施医学专著项目的成功经验。本文将具体的理论与策划项目实践相结合,可操作性强,期望为编辑在策划实践过程中提供一些指导和帮助。%This paper mainly introduces how to master the advance of academic development in a variety of ways such as attending academic conferences during the preparation of selected topics planning.Furthermore, the author shares the experiences of planning and performing the projects of medical monographs utilizing dif-ferent ways.This paper is practical,which combines concrete theories with the practice of planning selected topics,aiming at providing some guidance and assistance to editors during their topic planning.

  9. Asymptotic analysis of the Forward Search

    DEFF Research Database (Denmark)

    Johansen, Søren; Nielsen, Bent

    The Forward Search is an iterative algorithm concerned with detection of outliers and other unsuspected structures in data. This approach has been suggested, analysed and applied for regression models in the monograph Atkinson and Riani (2000). An asymptotic analysis of the Forward Search is made....... The argument involves theory for a new class of weighted and marked empirical processes, quantile process theory, and a fixed point argument to describe the iterative element of the procedure....

  10. Risk assessment and economic impact analysis of the implementation of new European legislation on radiopharmaceuticals in Italy: the case of the new monograph chapter Compounding of Radiopharmaceuticals (PHARMEUROPA, Vol. 23, No. 4, October 2011).

    Science.gov (United States)

    Chitto, Giuseppe; Di Domenico, Elvira; Gandolfo, Patrizia; Ria, Francesco; Tafuri, Chiara; Papa, Sergio

    2013-12-01

    An assessment of the new monograph chapter Compounding of Radiopharmaceuticals has been conducted on the basis of the first period of implementation of Italian legislation on Good Radiopharmaceuticals Practice (NBP) in the preparation of radiopharmaceuticals, in keeping with Decree by the Italian Ministry of Health dated March 30, 2005. This approach is well grounded in the several points of similarity between the two sets of regulations. The impact on patient risk, on staff risk, and on healthcare organization risk, has been assessed. At the same time, the actual costs of coming into compliance with regulations have been estimated. A change risk analysis has been performed through the identification of healthcare-associated risks, the analysis and measurement of the likelihood of occurrence and of the potential impact in terms of patient harm and staff harm, and the determination of the healthcare organization's controlling capability. In order to evaluate the economic impact, the expenses directly related to the implementation of the activities as per ministerial decree have been estimated after calculating the overall costs unrelated to NBP implementation. The resulting costs have then been averaged over the total number of patient services delivered. NBP implementation shows an extremely positive impact on risk management for both patients receiving Nuclear Medicine services and the healthcare organization. With regard to healthcare workers, instead, the implementation of these regulations has a negative effect on the risk for greater exposure and a positive effect on the defense against litigation. The economic impact analysis of NBP implementation shows a 34% increase in the costs for a single patient service. The implementation of the ministerial decree allows for greater detectability of and control over a number of critical elements, paving the way for risk management and minimization. We, therefore, believe that the proposed tool can provide basic

  11. 关于中国美术史中佛教石窟美术专题教学的探讨%The Discussion on Buddhism Grotto Art Monographic Teaching in History of Chinese Fine Arts

    Institute of Scientific and Technical Information of China (English)

    刘韬; 郭早早; 朱文晶

    2011-01-01

    The article mostly discusses some questions on Buddhism grotto art monograpmc teacmng m History of Chinese Fine Arts. The instructional objectives are three aspects that are grasping rudimentary knowledge, extension of art cultivation and increasing of research competence. The article mostly elaborates that settings arrangement of course content, the supple of teaching method bringing in video information, paying attention to the concepts of "cultural circle"and "model"in the course of teaching. The article indicates that we should bring academic history into Grotto art monographic teaching, so we can lead undergraduates to hackle research method on grotto art and to discover new questions.%本文主要讨论了中国美术史中佛教石窟美术专题教学的相关问题,将教学目标设计为基础知识掌握、美术修养扩充及研究能力提高三方面。主要阐述包括课程内容的设置安排、授课过程中引入视频教学资料教学方法补充、在具体授课过程中注意“文化圈”、“样式”等概念的问题,并指出将佛教石窟研究的学术史引入到石窟美术专题教学中,从而引导学生总结梳理石窟美术的研究方法与发现新问题。

  12. Edited volumes, monographs and book chapters in the Book Citation Index (BKCI) and Science Citation Index (SCI, SoSCI, A&HCI)

    NARCIS (Netherlands)

    Leydesdorff, L.; Felt, U.

    2012-01-01

    In 2011, Thomson-Reuters introduced the Book Citation Index (BKCI) as part of the Science Citation Index (SCI). The interface of the Web of Science version 5 enables users to search for both 'Books' and 'Book Chapters' as new categories. Books and book chapters, however, were always among the cited

  13. Exploring and practice of monographic pedagogy in the course“An Introduction to Basic Principles of Marxism”%“马克思主义基本原理”课程专题式教学改革的探索与实践

    Institute of Scientific and Technical Information of China (English)

    晏湘涛

    2015-01-01

    The reform of monographic pedagogy in the course “An Introduction to Basic Principles of Marxism”should aim to the reform of monographic,research orient and practice.Special topics should be set to solve the students’thought puzzles and theory problems.Students’forum is a proper tool to stimulate students to join this course.The academic taste should be high-lighted to improve students’ability to solve reality problem using Marxism principles.%“马克思主义基本原理”课程的专题式教学改革,应以“专题式研究型实践性”教学模式改革为总体目标,科学设置专题,切实解开学员现实关切的思想疑惑和理论扣子;要将“学员论坛”作为专题式教学的重要形式,充分调动和发挥学员参与政治理论课的积极性、主动性、创造性;在专题式教学中突出学术品位,切实提高学员运用马克思主义基本原理解决现实问题的能力。

  14. On the First Monograph On the Strange Tales of Liao Zhai---Liao Zhai Fa Wei%论《聊斋志异》研究史上的索隐派--《聊斋发微》

    Institute of Scientific and Technical Information of China (English)

    朱泽宝

    2015-01-01

    As the first monograph on the strange tales of liao zhai,Wen Hensh-eng's liao zhai fa wei divide the motif of strange tales of liao zhai into five parts:grieving on failing races,angry about power,jealous of wealth,despising on scholars,worshiping on swordsman.Above all,grieving on failing races is the ma-in spirits of strange tales of liao zhai. Interested in detecting the secret history, Liao zhai fa wei takes all foxes written by Pu Songling as Manchu. In his opin-ion,Pu Songling intended to revolt against qing dynasty by literature. The reaso-n that the absurd opinion arise is that bias on minority and shortage of related knowledge. However,some ideas in that book are also inspiring.%问恨生的《聊斋发微》是聊斋研究史上的第一部专著,将《聊斋志异》全书的内容分为“悲种”、“愤势”、“嫉富”、“贱士”、“尚侠”五例。其中“悲种”为全书之主脑,其他四例皆由此生发。《聊斋发微》有着明显的“索隐派”作风,将《聊斋志异》中的狐视为胡,认为书中的鬼狐与人的恋爱传奇隐喻着蒲松龄的反清思想。《聊斋发微》的主要观点是不值一驳的,其错误产生的根源在于作者的民族偏见与相关知识的欠缺,但书中的某些观点对于今天的《聊斋志异》研究也有所启发。

  15. The discipline construction of medical image technology and analysis of the academic monograph%我国医学影像技术学科建设及相关专著情况分析

    Institute of Scientific and Technical Information of China (English)

    王骏; 刘小艳

    2016-01-01

    Today’s medical imaging has developed from a single observation of organisms’ anatomy and the change of morphology under the physiological and pathological conditions to the study of biology function and activity mechanism. Furthermore, it has entered into the molecular imaging. Through the analysis of 25 academic monograph and the experiences of convening three national editorial committees, the author successfully analyzes. Before writing, the author should carry out the market research and the writings should be deigned for a readership. The writing team must be equipped with academic quality as well as humanistic quality. And the comprehensive quality of the premier author is of great importance. He needs to call together all the members of the committee to have an all-round and deep communication, do the job as unifying the drafts, advertise sales and revise.%当今的医学成像已从过去单一的观测生理、病理条件下的生物体解剖结构以及形态学上的变化,发展到研究生物体功能与活动机制,并进入到分子影像。通过对25部医学影像技术学相关专著的分析,以及3次全国性编委会的参与认为:医学影像技术学科建设及专著的写作前需进行市场调研与策划,并针对一定的读者群展开;创作团队必须具备一定的学术素养与人文素养,尤其是第一主编的综合素质至关重要;此外,还需召集编委会进行全方位、深层次地沟通,做好统稿、宣传、销售以及修订的善后工作。

  16. LAMPF: the meson factory. A LASL monograph

    Energy Technology Data Exchange (ETDEWEB)

    Allred, J.C.

    1977-08-01

    A general and simplified introduction to the entire concept of LAMPF is given in terms of its experimental capabilities. Parts of the current experimental program are used as illustrative examples. Topics discussed include: (1) the evolution of the meson factory; (2) accelerator construction; (3) strong focusing; (4) accelerator innovations at LAMPF; (5) photons and pions; (6) muons as nuclear probes; (7) nuclear chemistry; (8) radiobiology and medical applications; (9) radioisotope production; (10) materials testing; and (11) LAMPF management and users group. (PMA)

  17. A monograph of the Vochysiaceae. IV. Erisma

    NARCIS (Netherlands)

    Stafleu, F.A.

    1955-01-01

    The genus Erisma is found in the Amazonian basin and in the Guianas; it comprises 16 species as defined in this paper, all of them typical Hylaean forest trees. The genus was first described by RUDGE in 1805; its name is a greek word meaning “a cause of dispute”. RUDGE may have wanted it to refer to

  18. A monograph of the Vochysiaceae. II. Callisthene

    NARCIS (Netherlands)

    Stafleu, F.A.

    1952-01-01

    The genus Callisthene is found in the Extra Amazonian part of the Brazilian mainland, particularly in the zone of the campos and in the adjacent parts of Bolivia. The genus comprises eight species, as defined in this paper. It shows its greatest diversity on the central plateau of the Brazilian stat

  19. A Monograph of the Vochysiaceae III. Qualea

    NARCIS (Netherlands)

    Stafleu, F.A.

    1953-01-01

    The genus Qualea is found in tropical South America, particularly in the Hylaea and in the Extra Amazonian part of the Brazilian mainland (see fig. 3); it comprises 59 species as defined in this paper. Many species are forest trees occurring in the Amazonian basin, a number are found in the Brazilia

  20. A Monograph on Spanish Palaeozoic Crinoidea

    NARCIS (Netherlands)

    Breimer, A.

    1962-01-01

    It has been the aim of this study to give a comprehensive description of the important crinoid fauna's of the Palaeozoic core of North Western Spain (provinces Palencia, León and Asturias). This was opportune since fine collections of crinoids had been made during the years 1955—1960 by students of

  1. Monograph: Young Adulthood and Middle Age, 1989.

    Science.gov (United States)

    Monograph: Young Adulthood and Middle Age, 1989

    1989-01-01

    The inaugural volume of this serial contains 12 articles that represent a diverse population of counselors: (1) "Issues in Counseling Immigrants" (Linda Sheppard); (2) "Family Support and Starting a Small Business" (Michael Cusack and Peter Emerson); (3) "Professional Disillusionment: Crisis or Catalyst" (Kay Miller, Susan Cooper-Shoup and…

  2. Monograph On Bothid Larvae (Pleuronectiformes - Pisces)

    Digital Repository Service at National Institute of Oceanography (India)

    Devi, C.B.L.

    The scarcity of larval material in the IIOE collections, the faulty preservation which led to the mutilation and dismembering of parts of the specimens as well as nonavailability of connecting links between various stages have been serious handicaps...

  3. A monograph of the genus Evolvulus

    NARCIS (Netherlands)

    Ooststroom, van S.J.

    1934-01-01

    The great difficulties arising in the identification of a number of plants belonging to the genus Evolvulus, which plants were found in several recent collections of Convolvulaceae and were kindly entrusted to me for study, induced me to submit this genus to a further examination. It soon proved how

  4. A monograph of the Genus Aristida

    NARCIS (Netherlands)

    Henrard, J.Th.

    1929-01-01

    In a preliminary work: „A critical Revision of the genus Aristida”, I have given a review of all the hitherto described species of this genus with the citation of the literature, the exact copies of the authentic descriptions and the figures of the spikelet-characters, taken from the type specimens

  5. A Monograph on St. Vincent's Game Preserve

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document describes the geography, history, climate, and wildlife of St. Vincent’s Game Preserve. Photographs, maps, articles, and letters are included.

  6. Bibliography of Nursing Monographs, 1970-1978.

    Science.gov (United States)

    Ewens, Wilma A., Comp.; And Others

    This list consists of titles published since 1970 on nursing, grouping them into five broad categories: (1) nursing practice, including clinical nursing, communication, community health, emergency care, family health, obstetrics, and universal self care; (2) nursing as a profession; (3) educational aspects of nursing; (4) basic health science…

  7. A Monograph of Conostegia (Melastomataceae, Miconieae).

    Science.gov (United States)

    Kriebel, Ricardo

    2016-01-01

    A recent molecular phylogenetic analysis identified a clade containing all species of Conostegia, but that also included species of Clidemia and Miconia nested inside. A taxonomic revision of a more broadly circumscribed Conostegia is presented here. In total, 77 species of Conostegia are recognized. One species from Ecuador, Conostegia ortizae is described as new. Twenty-nine new combinations are proposed for the species of Clidemia and Miconia that fall inside Conostegia. Two new names are proposed for the two species for which the epithet was previously occupied in Conostegia. An infrageneric classification of Conostegia is proposed recognizing three sections based on the results of the molecular phylogeny. This taxonomic revision includes ample documentation of the anatomy and morphology of most species in the genus, taxonomic descriptions, a dichotomous key, and distribution maps for all species.

  8. A MONOGRAPH OF CARYODAPHNOPSIS A. SHAW

    Directory of Open Access Journals (Sweden)

    a. j. g. h. kostermans

    1974-12-01

    Full Text Available Of the genus Caryodapknopaia 7 species are known, of which twoare described here for the first time. The genus occurs from Yunnanto Indochina, with the exception of C. tonkinensis, which goes as far asthe Philippines and Borneo. Apparently most species are distributed bywater and C.tonkinensis is assumed to have spread from the mainlandto Borneo during the glacial period, when a land connection existed.The genus is related to Nothaphoebe and Alseodaphne and hencebelongs to Perseae.

  9. Journal Writing: Pedagogical Perspectives. [SFC Monograph #3.

    Science.gov (United States)

    Casanave, Christine Pearson, Ed.

    Articles on the use of student journals in high school and college English-as-a-Second-Language instruction, specifically in the Japanese context, include: "Journal Writing and the Damaged Language Learner" (Alan J. McCormick); "Interested?" (Sven G. M. Puetter); "Tradition and the Student Journal" (George Deaux);…

  10. Bibliography of Nursing Monographs, 1970-1978.

    Science.gov (United States)

    Ewens, Wilma A., Comp.; And Others

    This list consists of titles published since 1970 on nursing, grouping them into five broad categories: (1) nursing practice, including clinical nursing, communication, community health, emergency care, family health, obstetrics, and universal self care; (2) nursing as a profession; (3) educational aspects of nursing; (4) basic health science…

  11. Monograph of the genus Phylacium (Leguminosae)

    NARCIS (Netherlands)

    Bresser, Mirjam

    1978-01-01

    In the genus Phylacium 2 species are recognized. Special attention is paid to the morphology of the inflorescence; full descriptions are given with plates and a map, showing the distribution of both species.

  12. Illinois wetlands: their value and management. [Monograph

    Energy Technology Data Exchange (ETDEWEB)

    Bell, H.E. III

    1981-01-01

    Wetlands are now valued as an important habitat, for their moderation of flooding, and as free polutant filters. This report documents, with the aid of aerial photographs, the impact of drainage activities for development purposes over the past century, and illustrates the environmental significance of wetlands. There are various techniques available for protecting wetlands, including the use of permits, the Endangered Species Act, floodplain zoning, acquisition, management and restoration, and legislation at all levels of government. The preservation of wetlands is shown to contribute to the well-being of all Illinois citizens. 168 references, 17 tables.

  13. A monograph of the genus Barringtonia (Lecythidaceae)

    NARCIS (Netherlands)

    Payens, J.P.D.W.

    1967-01-01

    A brief history is given on the circumscription and subdivision of Lecythidaceae and the position of Barringtonia. All aspects, also of auxiliary disciplines point to affinity with Myrtaceae but warrant separate family status. The conviction is that only one family is concerned, not two, or even thr

  14. Vegetation Map and Vegetation Monographs of China

    Institute of Scientific and Technical Information of China (English)

    GUO Ke

    2010-01-01

    @@ Vegetation Map of China As the most significant component of an ecosystem,vegetation plays the most important role in maintaining biodiversity and providing the necessary resources for human beings.A vegetation map shows the major vegetation types of a region and their geographic distribution patterns.

  15. A monograph of the Genus Aristida

    NARCIS (Netherlands)

    Henrard, J.Th.

    1929-01-01

    In a preliminary work: „A critical Revision of the genus Aristida”, I have given a review of all the hitherto described species of this genus with the citation of the literature, the exact copies of the authentic descriptions and the figures of the spikelet-characters, taken from the type specimens

  16. Energy and reality: three perceptions. [Monograph

    Energy Technology Data Exchange (ETDEWEB)

    Benson, J.W.

    1977-01-01

    Three perceptual patterns reflecting different value orientations are examined in terms of whether they view the energy problem as one of supply and demand; one of intolerable social, economic, and environmental costs; or one of misdirected societal goals. Each of these perceptions is analyzed and compared with the others to identify criteria that society might adopt in making its choice. These criteria could ask whether the view leads toward societal and ecosystem adaptability and survival, whether it furthers human civilization, and whether it is compatible with human nature. The policy implications drawn from these considerations are that technological and economic arguements are an inadequate basis for major decisions, including the decision to pursue a soft energy path. A determination of the kind of society man wants is a prerequisite to choosing the solar or the nuclear option. 34 references. (DCK)

  17. 一部集中我国研究型医院理论和实践结合发展研究成果的专著%A monograph focus on research the development theory and practice in China researching-type hospital

    Institute of Scientific and Technical Information of China (English)

    王明晓

    2016-01-01

    Some of researching type hospital have been built since 2004 when the concept of researching type hospital was presented by QIN Yinhe, the president of general hospital of PLA. To communication the results of the development theory and practice in China researching-type hospital, a monograph named research type hospital management focused on theory and practice of research type hospital development has been compiled by QIN Yinhe and his team since 2013. The chapters of this monograph involves pandect, plan, leadership, research, human resources, transformation, teaching, nursing, quality, service, ideal, security, logistic, medical ethic, culture and safety and it is the newest and richest monograph which can reflect the general quality of hospital management.%自2004年解放军总医院原院长秦银河教授提出创建研究型医院以来,该理论不断得以丰富深化。以解放军总医院为代表,国内涌现了一批研究型医院。为了集中反映国内研究型医院理论和实践结合的研究成果,2013年开始,由秦银河教授担任主编,集中全国数百名医院管理专家,利用两年的时间,编撰出版了《研究型医院管理学》。该书分为总论、谋划、领导、科研、学科、人才、转化、教学、护理、质量、服务、信念、保障、后勤、医德、文化和安全等18个章节,是目前反映国内医院管理整体水平的一部专著。

  18. Sun Yirang and Compilation Style Catalogues——Taking Monograph on Literature of Wenzhou History as an Example%晚清朴学大师孙诒让与辑录体目录——以《温州经籍志》为例

    Institute of Scientific and Technical Information of China (English)

    李海英

    2012-01-01

    孙诒让的《温州经籍志》被赞为"地方艺文志之冠",但前人的评价要么过于笼统,要么认为其仅是模仿马端临和朱彝尊的辑录体体例而为。其实,与马端临的《文献通考.经籍考》和朱彝尊的《经义考》相比,《温州经籍志》对辑录体做了许多有益的补充,其主要表现在著录全面兼及考辨、分类适当次序合理、著录内容详略得当3个方面,在目录著录体例上具有划时代的意义。%Monograph on Literature of Wenzhou History by Sun Yirang is admired as the best local Yiwenzhi.However,the former evaluation is too general,the other evaluation simply considered it as an imitation of compilation styles of Ma Duanlin and Zhu Yizun.In fact,comparing with Comprehensive Textual Research of Historical Documents by Ma Duanlin and Jing Yi Kao by Zhu Yizun,Monograph on Literature of Wenzhou History has more beneficial supplementary information for the compilation style,which is mainly reflected in following aspects: the comprehensive cataloguing and thorough analysis,appropriate classification and reasonable arrangement,and the combination of detailed and brief information in cataloguing content.It has the epoch-making historical significance to the catalogue style.

  19. The Generalizing Work on History and Culture of the Cossacks (Book Review: Essays on the History and Culture of the Cossacks of Southern Russia: Collective Monograph [Text] / ed. by G. G. Matishov, I. O. Tyumentsev ; Southern Scientic Centre of the Russian Academy of Sciences; Volgograd Branch of Federal State Budgetary Educational Institution of Higher Professional Education “Russian Presidential Academy of National Economy and Public Administration”. – Volgograd : Izd-vo Volgogradskogo Filiala FGBOU VPO RANKhiGS, 2014. – 624 p.

    Directory of Open Access Journals (Sweden)

    Bugay Nikolay F.

    2016-06-01

    Full Text Available This article represents a review of the collective monograph “Essays on the history and culture of the Cossacks of Southern Russia”, published in 2014 under the auspices of the Southern Scientific Centre of the Russian Academy of Sciences and the Volgograd branch of Russian Presidential Academy of National Economy and Public Administration. The review provides a critical analysis of the material in the collective monograph on the problems of studying the history and culture of the Cossacks. The author notes that the revival of Cossacks that began in the 1990s, not only drew attention to the Cossack problem in modern Russia, but also stimulated scientific and public interest in the history and culture of the Cossacks. Russian Cossacks have rich past and its culture is colorful and specific, its role in the history of Russia is significant. Issues of origin and development of the Cossacks, their place among the peoples of Russia, the specificity of cultural practices are constantly causing great interest for researchers. All this has led scientistsspecialists in the history and culture of the Cossacks to the idea of the creation of this scientific work, which has become a generalization of accumulated research experience on the most important issues of the Cossacks’ historical existence. The authors of the monograph limited their research by Southern Russia because of the complexity of creating general work on all Cossack troops which have historically existed in the Russian state and had sometimes very great cultural differences and special historical destiny. The authors made a very successful attempt to highlight the main problematic aspects of the history and culture of the Cossacks. The genre of essay chosen for creating a collective monograph, has allowed not only to identify the most relevant topics of the Cossack history and culture, but also to consider them in relation and development. Each essay contains material that allows to

  20. Summary of monographs made public in the 93rd meeting by West Japan Society of Naval Architects. Lecture meeting sponsored jointly by three shipbuilding societies for fall in 1996; Seibu zosenkai dai 93 kai reikai ronbun kogai. 1996 nendo shuki zosen sangakukai rengo koenkai

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    A lecture meeting sponsored by the three ship building societies for fall in 1996 was held on November 14 and 15, 1996 at the Hiroshima Prefecture Information Plaza, where 16 monographs were presented. With regard to fluid dynamic problems in vessels, reports were given on experimental studies on performance of tandem hydrofoils in highspeed regions, solution methods for non-steady two-dimensional hydrofoil problems by using a simple panel method, a consideration on lateral inclination during maneuvering operation, and a new prediction approach for ships maneuvering hydrodynamics. With respect to structural material strength, reports were made on one consideration on buckling and plastic breakdown strength characteristics of surface fine grain steel plates, a study on buckling and final strength of square plates subjected to load in combined planes, and one consideration on evaluating life to generate corrosion fatigue cracking. Other reports were also given on a theoretical study on sea shock load acting on two-dimensional floating bodies, a study on a method for setting design hydrographic conditions, and a numerical simulation on flow and density field in the Kagoshima bay in summer by using a multi-layer model.

  1. TheReview of“The Monographic Studies on the Current Hot Issues of Educatio:Issues of Educational Sociology”%一部驱动我国人力资源由大臻强的教育社会学力作--《当代教育热点问题专题研究:教育社会问题研究卷》意蕴钩玄

    Institute of Scientific and Technical Information of China (English)

    戴生岐; 刘宁

    2015-01-01

    《当代教育热点问题专题研究———教育社会问题研究卷》饱含对中国教育全息性问题系统性忧思:在思维方法上豁显着天地互文、内外联通的“实语”理路;在研究立场上显示出找回社会、倚重社会的场域归属;在研究导向上突出了殷忧淑世、兴教强国的问题意识;在研究心态上揭橥了“能近取譬”“得大自在”的文化自觉意识。%“The Monographic Studies on the Current Hot Issues of Education :Issues of Educational Sociology” is a monograph about educational sociology that is customized for solving the problems of Chi‐nese education .it contains the authors’ systematic anxieties about the overall issues of Chinese education . Concretely ,its thinking method clearly reveals the truthfully presentation orderliness that Heaven and Earth are correlated and the inside and the outside are united .The standpoint of the researches shows the field belongings to retrieve the society and relies on it .Its research guidance highlights the consciousness of problems that to care about the world as well as to promote education and make the country rich and strong .

  2. While Collaboration Is Increasing in the Profession the LIS Dissertation Remains a Solo-Authored Monograph. A Review of: Sugimoto, C. R. (2011. Collaboration in information and library science doctoral education. Library & Information Science Research, 33, 3-11. doi:10.1016/j.lisr.2010.05.003

    Directory of Open Access Journals (Sweden)

    Diana K. Wakimoto

    2011-09-01

    Full Text Available Objective – To investigate collaboration in LIS doctoral education, in particular the extent and perception of collaboration between advisors and advisees, and the dissertation as a collaborative product. Design – Quantitative and qualitative analysis of questionnaire data. Qualitative analysis of interviews. Bibliometric analysis of curricula vitae (CVs and dissertation citations.Setting – American Library Association (ALA-accredited, doctorate-granting schools in the United States and Canada. Subjects – A total of 374 full-time, tenured faculty members with the rank of associate or full professor (advisor group and 294 assistant professors (advisee group comprised the pool of faculty members (n=668 who were sent the questionnaire. Of these, 30 individuals participated in follow-up telephone interviews, which were equally split between the two groups. There were 97 faculty members from the original pool of 668 faculty members were included in the bibliometric analyses. Methods – The author developed two questionnaires, one for the advisors (associate and full professors and one for the advisees (assistant professors, and sent the surveys to faculty members at ALA-accredited schools in the United States and Canada. The questionnaires gathered information about the extent of collaboration and perceptions of collaboration in LIS doctoral education. The author also collected contact information from those interested in participating in a follow-up interview. The author selected the first 30 individuals who responded as the interview participants. The interview participants were split equally between advisors and advisees. A separate subpopulation of 97 faculty members was chosen for the bibliometric analysis phase of the study. These faculty members were chosen with the following criteria: graduation from an ALA-accredited school; full-text of dissertation available online; and a current, full CV available online. CVs were searched to

  3. 女教奇葩精彩绽放--评《当代教育热点问题专题研究--女性教育问题研究卷》%Wonderful Flowers of Women’s Education Blossoming Splendidly:Commentary on The Monographic Studies on the Current Hot Issues of Education:Women’s Education Issue

    Institute of Scientific and Technical Information of China (English)

    吴吉惠; 邓黎颜

    2015-01-01

    女性教育是当前教育界的热点话题之一,研究成果随着时间的推移逐渐丰富。值联合国第四次世界妇女大会通过《北京宣言》和《行动纲领》二十周年之际,杜学元教授及其研究团队为女性教育献上了《当代教育热点问题专题研究——女性教育问题研究卷》这份厚礼。该书具有研究团队学术水平较高、研究内容覆盖面广、研究结果信度高、研究对策针对性强等特点,有利于现代性别文化的形成、有利于女性教育政策的完善、也有利于女性教育实效性的增强。%Women’s education is one of the hot topics in the current educational circles, and the research achievements also become richer and richer as the time goes by. At the time of the adoption of Beijing Declaration at the Fourth World Women Conference of the United Nations and the 20th anniversary of Action Agenda, Professor Du Xueyuan and his research group present a generous gift for women’s education, that’s The Monographic Studies on the Current Hot Issues of Education. Women’s Education Issue. This book has the following features: strong scientific research abilities of the group members, wide coverage of its contents, reliable research results and highly targeted of its research strategies. It is to the benefit of the form of the modern gender culture, the perfection of women ’s education, as well as the enhancement of the effectiveness of women’s education.

  4. [Substance monograph on bisphenol A (BPA) - reference and human biomonitoring (HBM) values for BPA in urine. Opinion of the Human Biomonitoring Commission of the German Federal Environment Agency (UBA)].

    Science.gov (United States)

    2012-09-01

    Bisphenol A (BPA) is used for the production of polycarbonates and synthetic resins. Many of the items that contain BPA, for example polycarbonate bottles and coated cans, are commodities from which BPA can migrate into food and drinks, resulting in ubiquitous exposure of the population. Numerous animal studies and in vitro tests have shown that BPA acts as an "endocrine disruptor". Because of the still incomplete understanding of the complex and contradictory effects of BPA at doses below the NOAEL, the toxicological significance of recent findings is uncertain. The German HBM Commission takes notice that the risk assessment is currently in flux and that in the EU and other countries precautionary bans on BPA have been introduced. In the light of the extensive and growing body of literature, the Commission does not see itself in a position to resolve this controversy, nor to answer the question of the relevance of observed effects of low BPA doses on human health. The Commission has derived reference values (RV95) and TDI-based HBM I values for total BPA in urine. The RV95 values are 30 μg/l for 3-5 year olds, 15 μg/l for 6-14 year olds, and 7 μg/l for 20-29 year olds. The HBM I value for children is 1.5 mg/l and 2.5 mg/l for adults, respectively. The Commission emphasizes that the HBM values will require immediate adjustment should the current TDI of 0.05 mg/kg bw/day be changed. For the practical application of HBM, the Commission recommends an assessment based on the RV95. Confirmed exceedance of the RV95 by repeat measurements should prompt a search for the possible source(s), following the ALARA principle.

  5. Do princípio monográfico à unidade documentária: exploração dos fundamentos da Catalogação | From the monographic principle to the documentary unit: an exploration of the bases of Cataloguing

    Directory of Open Access Journals (Sweden)

    Cristina Dotta Ortega

    2011-03-01

    ípios gerais para a identificação da unidade documentária a partir da qual o registro de informação é construído. Palavras-chave catalogação; representação descritiva; princípio monográfico; unidade documentária; obra; assunto Abstract This article deals with the notion of documentary unit – a minimum informational unit, which is considered to be of interest of a group of users, liable to representation for the constitution of registration of a database – in order to explore the grounds of Cataloguing. Two conceptions have been taken into account: the concept of work proposed by Panizzi as part of the principles for the production of library catalogs, which was later resumed in the Functional Requirements for Bibliographic Records (FRBR model; and the concept of subject as a way to distinguish the intellectual unit (from the physical unit, developed by Documentation and applied in systems of scientific information. It starts from the assumption that these conceptions frame themselves as conceptual-historical approaches to the notion of documentary unit, therefore making  it  belong  to its problematization.  As methodology,  we have carried  out conceptual-historical approaches of the two conceptions mentioned above, and an analyses about their present contribution. First, this article contextualizes Cataloguing, dealing with its aims and with the existing terminology, bearing in mind the processes and tools of production and management of database. Second, it presents some of the principles of Cataloging consolidated by Panizzi in the middle of 19th century, and the monographic principle proposed by Otlet for documentation based on those principles. Then, it discusses those principles and their applications along the 20th century. The article observes that the scenery portraited by these two conceptions, respectively under the predominance of the community of libraries, and the services and nets of scientific information, has taken new contours during

  6. An Overview of Dental Radiology. NCHCT Monograph Series.

    Science.gov (United States)

    Manny, Edward F.; And Others

    This overview of dental radiology contains sections on demographics, equipment, dental radiology quality assurance, efficacy, dental radiology education curricula, professional organizations' guidelines for training and use, and state activities. In section 1 dental personnel, population of dental personnel, employment and earning prospects,…

  7. Biowaiver monographs for immediate release solid oral dosage forms: rifampicin.

    Science.gov (United States)

    Becker, C; Dressman, J B; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2009-07-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of new multisource and reformulated immediate release (IR) solid oral dosage forms containing rifampicin as the only Active Pharmaceutical Ingredient (API) are reviewed. Rifampicin's solubility and permeability, its therapeutic use and index, pharmacokinetics, excipient interactions and reported BE/bioavailability (BA) problems were taken into consideration. Solubility and absolute BA data indicate that rifampicin is a BCS Class II drug. Of special concern for biowaiving is that many reports of failure of IR solid oral dosage forms of rifampicin to meet BE have been published and the reasons for these failures are yet insufficiently understood. Moreover, no reports were identified in which in vitro dissolution was shown to be predictive of nonequivalence among products. Therefore, a biowaiver based approval of rifampicin containing IR solid oral dosage forms cannot be recommended for either new multisource drug products or for major scale-up and postapproval changes (variations) to existing drug products.

  8. Biowaiver monographs for immediate release solid oral dosage forms: efavirenz.

    Science.gov (United States)

    Cristofoletti, Rodrigo; Nair, Anita; Abrahamsson, Bertil; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2013-02-01

    Literature data pertaining to the decision to allow a waiver of in vivo bioequivalence testing for the approval of immediate-release (IR) solid oral dosage forms containing efavirenz as the only active pharmaceutical ingredient (API) are reviewed. Because of lack of conclusive data about efavirenz's permeability and its failure to comply with the "high solubility" criteria according to the Biopharmaceutics Classification System (BCS), the API can be classified as BCS Class II/IV. In line with the solubility characteristics, the innovator product does not meet the dissolution criteria for a "rapidly dissolving product." Furthermore, product variations containing commonly used excipients or in the manufacturing process have been reported to impact the rate and extent of efavirenz absorption. Despite its wide therapeutic index, subtherapeutic levels of efavirenz can lead to treatment failure and also facilitate the emergence of efavirenz-resistant mutants. For all these reasons, a biowaiver for IR solid oral dosage forms containing efavirenz as the sole API is not scientifically justified for reformulated or multisource drug products.

  9. Biowaiver monographs for immediate release solid oral dosage forms: prednisone.

    Science.gov (United States)

    Vogt, M; Derendorf, H; Krämer, J; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2007-06-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing prednisone are reviewed. Due to insufficient data prednisone cannot be definitively classified according to the current Biopharmaceutics Classification System (BCS) criteria as both the solubility and the permeability of prednisone are on the borderline of the present criteria of BCS Class I. Prednisone's therapeutic indications and therapeutic index, pharmacokinetics and the possibility of excipient interactions were also taken into consideration. Available evidence indicates that a biowaiver for IR solid oral dosage forms formulated with the excipients tabulated in this article would be unlikely to expose patients to undue risks.

  10. Biowaiver monographs for immediate release solid oral dosage forms: cimetidine.

    Science.gov (United States)

    Jantratid, E; Prakongpan, S; Dressman, J B; Amidon, G L; Junginger, H E; Midha, K K; Barends, D M

    2006-05-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing cimetidine are reviewed. According to the current Biopharmaceutics Classification System (BCS), cimetidine would be assigned to Class III. Cimetidine's therapeutic use and therapeutic index, its pharmacokinetic properties, data related to the possibility of excipient interactions, and reported BE/bioavailability (BA) problems were also taken into consideration. On the basis of the overall evidence, a biowaiver can be recommended for cimetidine IR products, provided that the test product contains only those excipients reported in this paper in their usual amounts, and that the test and the comparator drug products both are "rapidly dissolving" as per BCS.

  11. Biowaiver monographs for immediate release solid oral dosage forms: furosemide.

    Science.gov (United States)

    Granero, G E; Longhi, M R; Mora, M J; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2010-06-01

    Literature and new experimental data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing furosemide are reviewed. The available data on solubility, oral absorption, and permeability are sufficiently conclusive to classify furosemide into Class IV of the Biopharmaceutics Classification System (BCS). Furosemide's therapeutic use and therapeutic index, its pharmacokinetic properties, data related to the possibility of excipient interactions and reported BE/bioavailability (BA) problems are also taken into consideration. In view of the data available, it is concluded that the biowaiver procedure cannot be justified for either the registration of new multisource drug products or major postapproval changes (variations) to existing drug products.

  12. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Levetiracetam.

    Science.gov (United States)

    Petruševska, Marija; Berglez, Sandra; Krisch, Igor; Legen, Igor; Megušar, Klara; Peternel, Luka; Abrahamsson, Bertil; Cristofoletti, Rodrigo; Groot, D W; Kopp, Sabine; Langguth, Peter; Mehta, Mehul; Polli, James E; Shah, Vinod P; Dressman, Jennifer

    2015-09-01

    Literature and experimental data relevant for the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing levetiracetam are reviewed. Data on solubility and permeability suggest that levetiracetam belongs to class I of the biopharmaceutical classification system (BCS). Levetiracetam's therapeutic use, its wide therapeutic index, and its favorable pharmacokinetic properties make levetiracetam a valid candidate for the BCS-based biowaiver approach. Further, no BE studies with levetiracetam IR formulations in which the test formulation failed to show BE with the comparator have been reported in the open literature. On the basis of the overall evidence, it appears unlikely that a BCS-based biowaiver approach for levetiracetam IR solid oral dosage forms formulated with established excipients would expose patients to undue risks. Thus, the BCS-based biowaiver approach procedure is recommended for IR solid oral dosage form containing levetiracetam, provided the excipients in the formulation are also present in products that have been approved in countries belonging to or associated with the International Committee on Harmonization and are used in their usual quantities, and provided the dissolution profiles of the test and reference product comply with the current requirements for BCS-based biowaivers.

  13. Biowaiver monographs for immediate release solid oral dosage forms: isoniazid.

    Science.gov (United States)

    Becker, C; Dressman, J B; Amidon, G L; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2007-03-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing isoniazid as the only active pharmaceutical ingredient (API) are reviewed. Isoniazid's solubility and permeability characteristics according to the Biopharmaceutics Classification System (BCS), as well as its therapeutic use and therapeutic index, its pharmacokinetic properties, data related to the possibility of excipient interactions and reported BE/bioavailability (BA) problems were taken into consideration. Isoniazid is "highly soluble" but data on its oral absorption and permeability are inconclusive, suggesting this API to be on the borderline of BCS Class I and III. For a number of excipients, an interaction with the permeability is extreme unlikely, but lactose and other deoxidizing saccharides can form condensation products with isoniazid, which may be less permeable than the free API. A biowaiver is recommended for IR solid oral drug products containing isoniazid as the sole API, provided that the test product meets the WHO requirements for "very rapidly dissolving" and contains only the excipients commonly used in isoniazid products, as listed in this article. Lactose and/or other deoxidizing saccharides containing formulations should be subjected to an in vivo BE study.

  14. Biowaiver monographs for immediate release solid oral dosage forms: levofloxacin.

    Science.gov (United States)

    Koeppe, Marcelle O; Cristofoletti, Rodrigo; Fernandes, Eduardo F; Storpirtis, Silvia; Junginger, Hans E; Kopp, Sabine; Midha, Kamal K; Shah, Vinod P; Stavchansky, Salomon; Dressman, Jennifer B; Barends, Dirk M

    2011-05-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing levofloxacin as the only active pharmaceutical ingredient (API) are reviewed. According to the current Biopharmaceutics Classification System, levofloxacin can be assigned to Class I. No problems with BE of IR levofloxacin formulations containing different excipients and produced by different manufacturing methods have been reported and hence the risk of bioinequivalence caused by these factors appears to be low. In addition, levofloxacin has a wide therapeutic index. On the basis of this evidence, a biowaiver is recommended for IR solid oral dosage forms containing levofloxacin as the single API provided that (a) the test product contains only excipients present in IR levofloxacin drug products that have been approved in International Conference on Harmonization (ICH) or associated countries and which have the same dosage form; (b) both the test and comparator dosage form are "very rapidly dissolving" or "rapidly dissolving" with similarity of the dissolution profiles demonstrated at pH 1.2, 4.5, and 6.8; and (c) if the test product contains polysorbates, it should be both qualitatively and quantitatively identical to its comparator in terms of polysorbate content.

  15. Biowaiver monographs for immediate release solid oral dosage forms: metronidazole.

    Science.gov (United States)

    Rediguieri, Camila F; Porta, Valentina; G Nunes, Diana S; Nunes, Taina M; Junginger, Hans E; Kopp, Sabine; Midha, Kamal K; Shah, Vinod P; Stavchansky, Salomon; Dressman, Jennifer B; Barends, Dirk M

    2011-05-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing metronidazole are reviewed. Metronidazole can be assigned to Biopharmaceutics Classification System Class I. Most BE studies that were identified reported the investigated formulations to be bioequivalent, indicating the risk of bioinequivalence to be low. Formulations showing differences in bioavailability showed dissimilarities in in vitro dissolution profiles. Furthermore, metronidazole has a wide therapeutic index. It is concluded that a biowaiver for solid IR formulations is justified, provided: (a) the test product and its comparator are both rapidly dissolving; (b) meet similarity of the dissolution profiles at pH 1.2, 4.5, and 6.8; (c) the test product contains only excipients present in IR drug products approved in International Conference on Harmonisation (ICH) or associated countries in the same dosage form; and (d) if the test product contains sorbitol, sodium laurilsulfate, or propylene glycol, the test product needs to be qualitatively and quantitatively identical to its comparator with respect to these excipients [corrected]..

  16. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin.

    Science.gov (United States)

    Goodarzi, Navid; Barazesh Morgani, Ahmadreza; Abrahamsson, Bertil; Cristofoletti, Rodrigo; Groot, D W; Langguth, Peter; Mehta, Mehul U; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2016-04-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release solid oral dosage forms containing ribavirin are reviewed. Ribavirin is highly soluble, but its permeability characteristics are not well defined. Therefore according to the Biopharmaceutical Classification System, and taking a "worst case" approach, ribavirin should be assigned to class III. As ribavirin is transported across the brush border membrane of the human jejunum by hCNT2, it shows saturable uptake in the intestine. However, no common excipients have been shown to compete for ribavirin absorption, nor have problems with BE of immediate release ribavirin formulations containing different excipients and produced by different manufacturing methods been reported in the open literature. So the risk of bioinequivalence caused by these factors appears to be low. Ribavirin is considered a narrow therapeutic index drug, as judged by comparing the minimum effective concentration and minimum toxic concentrations in blood. Although ribavirin would not be eligible for approval via a Biopharmaceutical Classification System-based biowaiver procedure according to today's guidances due to its narrow therapeutic index, the risks of biowaiving should be weighed against the considerable risks associated with studying BE of ribavirin products in healthy subjects.

  17. Biowaiver monographs for immediate release solid oral dosage forms: prednisolone.

    OpenAIRE

    Vogt, M.; Derendorf, H; Krämer, J.; Junginger, H E; Midha, K.K.; Shah, V. P.; Stavchansky, S; Dressman, J B; Barends, D M

    2007-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing prednisolone are reviewed. Data on its solubility, oral absorption, and permeability are not totally conclusive, but strongly suggest a BCS Class 1 classification. Prednisolone's therapeutic indications and therapeutic index, pharmacokinetics, and the possibility of excipient interactions were also taken into considerat...

  18. Biowaiver monographs for immediate release solid oral dosage forms: piroxicam.

    Science.gov (United States)

    Shohin, Igor E; Kulinich, Julia I; Ramenskaya, Galina V; Abrahamsson, Bertil; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Groot, D W; Barends, Dirk M; Dressman, Jennifer B

    2014-02-01

    Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing piroxicam in the free acid form are reviewed. Piroxicam solubility and permeability, its therapeutic use and therapeutic index, pharmacokinetic properties, data related to the possibility of excipient interactions and reported BE/bioavailability (BA), and corresponding dissolution data are taken into consideration. The available data suggest that according to the current biopharmaceutics classification system (BCS) and all current guidances, piroxicam would be assigned to BCS Class II. The extent of piroxicam absorption seems not to depend on manufacturing conditions or excipients, so the risk of bioinequivalence in terms of area under the curve (AUC) is very low, but the rate of absorption (i.e., BE in terms of Cmax ) can be affected by the formulation. Current in vitro dissolution methods may not always reflect differences in terms of Cmax for BCS Class II weak acids; however, minor differences in absorption rate of piroxicam would not subject the patient to unacceptable risks: as piroxicam products may be taken before or after meals, the rate of absorption cannot be considered crucial to drug action. Therefore, a biowaiver for IR piroxicam solid oral dosage form is considered feasible, provided that (a) the test product contains only excipients, which are also present in IR solid oral drug products containing piroxicam, which have been approved in ICH or associated countries, for instance, those presented in Table 3 of this paper; (b) both the test and comparator drug products dissolve 85% in 30 min or less at pH 1.2, 4.5, and 6.8; and (c) the test product and comparator show dissolution profile similarity in pH 1.2, 4.5, and 6.8. When not all of these conditions can be fulfilled, BE of the products should be established in vivo.

  19. Biowaiver monographs for immediate release solid oral dosage forms: prednisolone.

    Science.gov (United States)

    Vogt, M; Derendorf, H; Krämer, J; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2007-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing prednisolone are reviewed. Data on its solubility, oral absorption, and permeability are not totally conclusive, but strongly suggest a BCS Class 1 classification. Prednisolone's therapeutic indications and therapeutic index, pharmacokinetics, and the possibility of excipient interactions were also taken into consideration. Available evidence indicates that a biowaiver for IR solid oral dosage forms formulated with the excipients tabulated in this article would be unlikely to expose patients to undue risks.

  20. Biowaiver monographs for immediate release solid oral dosage forms: aciclovir.

    Science.gov (United States)

    Arnal, J; Gonzalez-Alvarez, I; Bermejo, M; Amidon, G L; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2008-12-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing (biowaiver) for the approval of immediate release (IR) solid oral dosage forms containing aciclovir are reviewed. Aciclovir therapeutic use and therapeutic index, pharmacokinetic properties, data related to the possibility of excipient interactions and reported BE/bioavailability (BA) studies were also taken into consideration in order to ascertain whether a biowaiver can be recommended. According to the Biopharmaceutics Classification System (BCS) and considering tablet strengths up to 400 mg, aciclovir would be BCS Class III. However, in some countries also 800 mg tablets are available which fall just within BCS Class IV. Aciclovir seems not to be critical with respect to a risk for bioinequivalence, as no examples of bioinequivalence have been identified. It has a wide therapeutic index and is not used for critical indications. Hence, if: (a) the test product contains only excipients present in aciclovir solid oral IR drug products approved in ICH or associated countries, for instance as presented in this article; and (b) the comparator and the test product both are very rapidly dissolving, a biowaiver for IR aciclovir solid oral drug products is considered justified for all tablet strengths.

  1. Biowaiver monographs for immediate release solid oral dosage forms: ibuprofen.

    Science.gov (United States)

    Potthast, H; Dressman, J B; Junginger, H E; Midha, K K; Oeser, H; Shah, V P; Vogelpoel, H; Barends, D M

    2005-10-01

    Literature data are reviewed on the properties of ibuprofen related to the biopharmaceutics classification system (BCS). Ibuprofen was assessed to be a BCS class II drug. Differences in composition and/or manufacturing procedures were reported to have an effect on the rate, but not the extent of absorption; such differences are likely to be detectable by comparative in vitro dissolution tests. Also in view of its therapeutic use, its wide therapeutic index and uncomplicated pharmacokinetic properties, a biowaiver for immediate release (IR) ibuprofen solid oral drug products is scientifically justified, provided that the test product contains only those excipients reported in this paper in their usual amounts, the dosage form is rapidly dissolving (85% in 30 min or less) in buffer pH 6.8 and the test product also exhibits similar dissolution profiles to the reference product in buffer pH 1.2, 4.5, and 6.8.

  2. Biowaiver monographs for immediate release solid oral dosage forms: pyrazinamide.

    Science.gov (United States)

    Becker, C; Dressman, J B; Amidon, G L; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2008-09-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing pyrazinamide as the only active pharmaceutical ingredient (API) are reviewed. Pyrazinamide is BCS Class III, with linear absorption over a wide dosing range. The risk of bioinequivalence is estimated to be low. Depending on the definition used, pyrazinamide can be classified as a narrow therapeutic index (NTI) drug, which is usually a caveat to biowaiving but may be deemed acceptable if the Summary of Product Characteristics (SmPCs) of the test product stipulates the need for regular monitoring of liver function. It is concluded that a biowaiver can be recommended for IR solid oral dosage only when the test product (a) contains only excipients present in pyrazinamide IR solid oral drug products approved in ICH or associated countries, (b) these excipients are present in amounts normally used in IR solid oral dosage forms, (c) the test product is very rapidly dissolving, (d) the SmPC of the test product indicates the need for monitoring of the patient's liver function.

  3. Biowaiver monographs for immediate release solid oral dosage forms: prednisolone.

    NARCIS (Netherlands)

    Vogt, M; Derendorf, H; Krämer, J; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2007-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing prednisolone are reviewed. Data on its solubility, oral absorption, and permeability are not totally conclusive, but strongl

  4. Biowaiver monographs for immediate release solid oral dosage forms: lamivudine.

    Science.gov (United States)

    Strauch, S; Jantratid, E; Dressman, J B; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2011-06-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing lamivudine as the only active pharmaceutical ingredient were reviewed. The solubility and permeability data of lamivudine as well as its therapeutic index, its pharmacokinetic properties, data indicating excipient interactions, and reported BE/bioavailability (BA) studies were taken into consideration. Lamivudine is highly soluble, but its permeability characteristics are not well-defined. Reported BA values in adults ranged from 82% to 88%. Therefore, lamivudine is assigned to the biopharmaceutics classification system (BCS) class III, noting that its permeability characteristics are near the border of BCS class I. Lamivudine is not a narrow therapeutic index drug. Provided that (a) the test product contains only excipients present in lamivudine IR solid oral drug products approved in the International Conference on Harmonization or associated countries in usual amounts and (b) the test product as well as the comparator product fulfills the BCS dissolution criteria for very rapidly dissolving; a biowaiver can be recommended for new lamivudine multisource IR products and major post-approval changes of marketed drug products.

  5. Biowaiver monographs for immediate release solid oral dosage forms: acetazolamide.

    Science.gov (United States)

    Granero, G E; Longhi, M R; Becker, C; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2008-09-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing acetazolamide are reviewed. Acetazolamide's solubility and permeability characteristics according to the Biopharmaceutics Classification System (BCS), as well as its therapeutic use and therapeutic index, its pharmacokinetic properties, data related to the possibility of excipient interactions and reported BE/bioavailability (BA) problems are taken into consideration. The available data on solubility, on oral absorption and permeability are not sufficiently conclusive to classify acetazolamide with certainty. Taking a conservative approach, no biowaiver is considered justified for the registration of new multisource drug products. However, SUPAC level 1 and level 2 postapproval changes and most EU Type I variations can be approved waiving in vivo BE studies.

  6. Biowaiver monographs for immediate release solid oral dosage forms: cimetidine.

    NARCIS (Netherlands)

    Jantratid, E; Prakongpan, S; Dressman, J B; Amidon, G L; Junginger, H E; Midha, K K; Barends, D M

    2006-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing cimetidine are reviewed. According to the current Biopharmaceutics Classification System (BCS), cimetidine would be assigned

  7. Biowaiver monographs for immediate release solid oral dosage forms: cimetidine.

    OpenAIRE

    Jantratid, E; Prakongpan, S.; Dressman, J B; Amidon, G L; Junginger, H E; Midha, K.K.; Barends, D M

    2006-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing cimetidine are reviewed. According to the current Biopharmaceutics Classification System (BCS), cimetidine would be assigned to Class III. Cimetidine's therapeutic use and therapeutic index, its pharmacokinetic properties, data related to the possibility of excipient interactions, and reported BE/bioavailability (BA) pr...

  8. A monograph of the fern genus Goniophlebium (Polypodiaceae)

    NARCIS (Netherlands)

    Rödl-Linder, Gisela

    1990-01-01

    This study concentrates on the analysis of 34 species earlier referred to Polypodium Linnaeus (sensu lato) with a (partly) goniophlebioid venation pattern and also includes a selection of free veined Polypodium species. Status and nomenclature of the goniophlebioids are most ambiguous and show much

  9. Redesigning the Current Student Tracking Form. Action Research Monograph.

    Science.gov (United States)

    Urey, Donna

    A project was conducted to redesign the Pennsylvania Department of Education (PDE) Bureau of Adult Basic and Literacy Education required student tracking form to provide for better student tracking. The Student Intake and Data form supplied by the PDE from program year 1996-97 was used as a point of comparison, and evaluations of this form by…

  10. Biotechnology, Genetic Engineering and Society. Monograph Series: III.

    Science.gov (United States)

    Kieffer, George H.

    New techniques have expanded the field of biotechnology and awarded scientists an unprecedented degree of control over the genetic constitutions of living things. The knowledge of DNA science is the basis for this burgeoning industry which may be a major force in human existence. Just as it is possible to move genetic material from one organism to…

  11. The Chemistry of Vat Dyes. Palette of Color Monograph Series.

    Science.gov (United States)

    Epp, Dianne N.

    From prehistoric times people have been fascinated with color; from cave paintings to the latest computers, color has been a constant companion. Textiles are made more beautiful by the alteration or application of colorants. This teaching resource investigates vat dyes, a colorant class which includes the oldest dyes known as well as important…

  12. The Chemistry of Natural Dyes. Palette of Color Monograph Series.

    Science.gov (United States)

    Epp, Dianne N.

    From prehistoric times people have been fascinated with color; from cave paintings to the latest computers, color has been a constant companion. Textiles and craft items are made more beautiful by the alteration or application of colorants. This teaching resource investigates dyes obtained from natural sources, such as plants and animals. These…

  13. A monograph of the freshwater Bryozoa-Phylactolaemata

    NARCIS (Netherlands)

    Lacourt, A.W.

    1968-01-01

    1. This paper presents the taxonomy of the Bryozoa Phylactolaemata. The group is found to contain a number of series. The present classification reveals that a number of specific names are synonyms. 2. The evolution of the group is described on the basis of the development of the zoarium and the

  14. [Model for introducing or revitalizing the final monograph].

    Science.gov (United States)

    Saupe, Rosita; Wendhausen, Agueda Lenita Pereira; Machado, Heloisa Beatriz

    2004-01-01

    The requirement set by the Curricular Guidelines for a Course Conclusion Work in the nursing area is an innovation for the majority of courses in Brazil. Only a few courses have introduced this type of study as a result of their forward-looking vision. This requirement has demanded an effort from the universities, to ensure that these studies do not only represent an academic exercise, but also an institutional quality indicator and a possible contribution to the solution of social problems. Our proposed model includes: defining lines of research, gathering researchers per by area of interest, organizing research groups and centers, defining the preferred types of studies, planning operational agendas, carrying out a follow-up on their introduction and encouraging their publication.

  15. IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans

    NARCIS (Netherlands)

    Pearce, Neil E; Blair, Aaron; Vineis, Paolo; Ahrens, Wolfgang; Andersen, Aage; Anto, Josep M; Armstrong, Bruce K; Baccarelli, Andrea A; Beland, Frederick A; Berrington, Amy; Bertazzi, Pier A; Birnbaum, Linda S; Brownson, Ross C; Bucher, John R; Cantor, Kenneth P; Cardis, Elisabeth; Cherrie, John W; Christiani, David C; Cocco, Pierluigi; Coggon, David; Comba, Pietro; Demers, Paul A; Dement, John M; Douwes, Jeroen; Eisen, Ellen A; Engel, Lawrence S; Fenske, Richard A; Fleming, Lora E; Fletcher, Tony; Fontham, Elizabeth; Forastiere, Francesco; Frentzel-Beyme, Rainer; Fritschi, Lin; Gerin, Michel; Goldberg, Marcel; Grandjean, Philippe; Grimsrud, Tom K; Gustavsson, Per; Haines, Andy; Hartge, Patricia; Hansen, Johnni; Hauptmann, Michael; Heederik, Dick; Hemminki, Kari; Hemon, Denis; Hertz-Picciotto, Irva; Hoppin, Jane A; Huff, James; Jarvholm, Bengt; Kang, Daehee; Karagas, Margaret R; Kjaerheim, Kristina; Kjuus, Helge; Kogevinas, Manolis; Kriebel, David; Kristensen, Petter; Kromhout, Hans; Laden, Francine; Lebailly, Pierre; LeMasters, Grace; Lubin, Jay H; Lynch, Charles F; Lynge, Elsebeth; 't Mannetje, Andrea; McMichael, Anthony J; McLaughlin, John R; Marrett, Loraine; Martuzzi, Marco; Merchant, James A; Merler, Enzo; Merletti, Franco; Miller, Anthony; Mirer, Franklin E; Monson, Richard; Nordby, Karl-Kristian; Olshan, Andrew F; Parent, Marie-Elise; Perera, Frederica P; Perry, Melissa J; Pesatori, Angela C; Pirastu, Roberta; Porta, Miquel; Pukkala, Eero; Rice, Carol; Richardson, David B; Ritter, Leonard; Ritz, Beate; Ronckers, Cecile M; Rushton, Lesley; Rusiecki, Jennifer A; Rusyn, Ivan; Samet, Jonathan M; Sandler, Dale P; de Sanjose, Silvia; Schernhammer, Eva; Seniori Constantini, Adele; Seixas, Noah; Shy, Carl; Siemiatycki, Jack; Silvermann, Debra T; Simonato, Lorenzo; Smith, Allan H; Smith, Martyn T; Spinelli, John J; Spitz, Margaret R; Stallones, Lorann; Stayner, Leslie T; Steenland, Kyle; Stenzel, Mark; Stewart, Bernard W; Stewart, Patricia A; Symanski, Elaine; Terracini, Benedetto; Tolbert, Paige E; Vainio, Harri; Vena, John; Vermeulen, Roel; Victora, Cesar G; Ward, Elizabeth M; Weinberg, Clarice R; Weisenburger, Dennis; Wesseling, Catharina; Weiderpass, Elisabete; Zahm, Shelia H

    2015-01-01

    BACKGROUND: Recently the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also the approach used to perform these evaluations. Some critics have claimed that IARC Working Groups' fa

  16. Accommodation, Cafes and Restaurants. Industry Training Monograph No. 8.

    Science.gov (United States)

    Dumbrell, Tom

    Australia's accommodation, cafes, and restaurants industry represents more than half of the nation's total tourism and hospitality employment. It accounts for roughly 4.5% of all jobs in Australia (400,000 workers). Since 1987, the number of jobs in the sector has risen from about 257,000 to about 372,000. Approximately 57% of employees are…

  17. The Chemistry of Natural Dyes. Palette of Color Monograph Series.

    Science.gov (United States)

    Epp, Dianne N.

    From prehistoric times people have been fascinated with color; from cave paintings to the latest computers, color has been a constant companion. Textiles and craft items are made more beautiful by the alteration or application of colorants. This teaching resource investigates dyes obtained from natural sources, such as plants and animals. These…

  18. A MONOGRAPH OF THE GENUS DIPLODISCUS* Turcz. (TILIACEAE

    Directory of Open Access Journals (Sweden)

    A. J. G. H. KOSTERMANS

    2014-01-01

    Full Text Available 1. Seven species of the genus Diplodiscus are described, of which three(D. microlepis, D. parviflorus and D. decumbens are new to science, and one (D. hookerianus was formerly described as Pentace (for the description of D. decumbens cf. p. 264.2. The area of distribution of the genus covers the Malay Peninsula,Borneo and the Philippines.3. The affinities of the genus are discussed.4. A key to the species is presented.

  19. A seminal monograph: Mackay and Burnet's Autoimmune diseases.

    Science.gov (United States)

    Roberts-Thomson, Peter J; Jackson, Michael W; Gordon, Thomas P

    2012-01-16

    Mackay and Burnet's Autoimmune diseases, published in 1962, marked the beginning of autoimmunity as a clinical science and led to the future acceptance of the existence of autoimmunity. While there is still controversy regarding the mechanisms of autoimmunity, the authors' insightful hypothesis based on clonal selection theory and the emergence of "forbidden clones", due to somatic mutations, is still current, with recent evidence giving further credence to this hypothesis. We salute Mackay and Burnet on the 50th anniversary of this seminal publication. It is particularly pleasing that it has an iconic Australian origin.

  20. A taxonomic monograph of Nearctic Scolytus Geoffroy (Coleoptera, Curculionidae, Scolytinae

    Directory of Open Access Journals (Sweden)

    Sarah Smith

    2014-10-01

    Full Text Available The Nearctic bark beetle genus Scolytus Geoffroy was revised based in part on a molecular and morphological phylogeny. Monophyly of the native species was tested using mitochondrial (COI and nuclear (28S, CAD, ArgK genes and 43 morphological characters in parsimony and Bayesian phylogenetic analyses. Parsimony analyses of molecular and combined datasets provided mixed results while Bayesian analysis recovered most nodes with posterior probabilities >90%. Native hardwood- and conifer-feeding Scolytus species were recovered as paraphyletic. Native Nearctic species were recovered as paraphyletic with hardwood-feeding species sister to Palearctic hardwood-feeding species rather than to native conifer-feeding species. The Nearctic conifer-feeding species were monophyletic. Twenty-five species were recognized. Four new synonyms were discovered: S. praeceps LeConte, 1868 (= S. abietis Blackman, 1934; = S. opacus Blackman, 1934, S. reflexus Blackman, 1934 (= S. virgatus Bright, 1972; = S. wickhami Blackman, 1934. Two species were reinstated: S. fiskei Blackman, 1934 and S. silvaticus Bright, 1972. A diagnosis, description, distribution, host records and images were provided for each species and a key is presented to all species.

  1. A MONOGRAPH OF THE GENUS SCHOUTENIA* Korth. (Tiliaceae

    Directory of Open Access Journals (Sweden)

    ROEKMOWATI ROEKMOWATI

    2015-11-01

    Full Text Available The genus consists of 8 species in Siam, Indochina, the Malay Peninsula, Sumatra,Borneo, Java, and the Lesser Sunda Islands. It is here divided into 2 subgenera,the monotypic Schoutevia with S. cvata Korth. and Chartacalyx with S. accres-cens (Mast. Curtis as type species. Chartacalyx is divided into 2 sections, Char-tacalyx and A disci flora with S. kuiistleri King as type spscies.Three species, S. curtisii, corneri, and kostermansii are considered new.S. hypoleuca Pierre is reduced to synonymy of S. ovata Korth. S. peregrines Craib is reduced to a subspecies of S. glomerata King. The varieties of S. accrescens (Mast. Curtis are deleted. The species is dividedinto 3 subspecies: accrescens, stellata, and borneensis. A forma lepidota is reeog-nized for subspecies accrescens.. S. buurmanii K. et V. and S. kunstleri King- are considered to be differentspecies.

  2. A taxonomic monograph of Nearctic Scolytus Geoffroy (Coleoptera, Curculionidae, Scolytinae).

    Science.gov (United States)

    Smith, Sarah M; Cognato, Anthony I

    2014-01-01

    The Nearctic bark beetle genus Scolytus Geoffroy was revised based in part on a molecular and morphological phylogeny. Monophyly of the native species was tested using mitochondrial (COI) and nuclear (28S, CAD, ArgK) genes and 43 morphological characters in parsimony and Bayesian phylogenetic analyses. Parsimony analyses of molecular and combined datasets provided mixed results while Bayesian analysis recovered most nodes with posterior probabilities >90%. Native hardwood- and conifer-feeding Scolytus species were recovered as paraphyletic. Native Nearctic species were recovered as paraphyletic with hardwood-feeding species sister to Palearctic hardwood-feeding species rather than to native conifer-feeding species. The Nearctic conifer-feeding species were monophyletic. Twenty-five species were recognized. Four new synonyms were discovered: Scolytuspraeceps LeConte, 1868 (= Scolytusabietis Blackman, 1934; = Scolytusopacus Blackman, 1934), Scolytusreflexus Blackman, 1934 (= Scolytusvirgatus Bright, 1972; = Scolytuswickhami Blackman, 1934). Two species were reinstated: Scolytusfiskei Blackman, 1934 and Scolytussilvaticus Bright, 1972. A diagnosis, description, distribution, host records and images were provided for each species and a key is presented to all species.

  3. Bureau of Mines War Gas Investigations (WGI) Monographs (Old Series)

    Science.gov (United States)

    2015-01-01

    sulfide from Ethylene chloro- iodide: Helferich & Reid 5 394. Report on G-34: Conant 9 395. Report on the chlorination of Methyl sulfide...2 Preparation 2 3 Possible use of Ethylene dihalides 5 4 Nature of Diethylene disulfide 10 5 Possible use of Ethyl sulfide 13 6 German...method of manufacture 13 7 Manufacture A. Chlorhydrin method 15 1. Ethylene 16 2. Ethylene Chlorhydrin 25 3. Thiodiglycol 45

  4. U.S. Competitiveness in Science and Technology. Monograph. Summary

    Science.gov (United States)

    Galama, Titus; Hosek, James

    2008-01-01

    Is the United States in danger of losing its competitive edge in science and technology (S&T)? This concern has been raised repeatedly since the end of the Cold War, most recently in a wave of reports in the mid-2000s suggesting that globalization and the growing strength of other nations in S&T, coupled with inadequate U.S. investments in…

  5. U.S. Competitiveness in Science and Technology. Monograph

    Science.gov (United States)

    Galama, Titus; Hosek, James

    2008-01-01

    Is the United States in danger of losing its competitive edge in science and technology (S&T)? This concern has been raised repeatedly since the end of the Cold War, most recently in a wave of reports in the mid-2000s suggesting that globalization and the growing strength of other nations in S&T, coupled with inadequate U.S. investments in…

  6. New Monograph on Marine Science and International Law

    Science.gov (United States)

    The International Marine Science Cooperation Program at the Woods Hole Oceanographic Institution (Woods Hole, Mass.) announces its second publication, Marine Scientific Research Boundaries and the Law of the Sea: Discussion and Inventory of National Claims by David A. Ross and Therese A. Landry. The document is in two parts. The first section describes research boundaries and discusses specific articles of the Law of the Sea Treaty that bear on marine scientific research, while the second section is an inventory of the maritime claims by 139 countries.

  7. Values, Inquiry, and Education. CSE Monograph Series in Evaluation, 9.

    Science.gov (United States)

    Gideonse, Hendrik, Ed.; And Others

    This edited volume contains 16 social science-related educational research articles based on papers presented at the 1979 annual meeting of the American Educational Research Association (AERA). The articles and associated commentary are organized according to six symposia held at the meeting--anthropology, evaluation, history, political science,…

  8. A monograph on the remediation of hazardous phthalates.

    Science.gov (United States)

    Benjamin, Sailas; Pradeep, Selvanesan; Josh, Moolakkariyil Sarath; Kumar, Sunil; Masai, Eiji

    2015-11-15

    Phthalates or phthalic acid esters are a group of xenobiotic and hazardous compounds blended in plastics to enhance their plasticity and versatility. Enormous quantities of phthalates are produced globally for the production of plastic goods, whose disposal and leaching out into the surroundings cause serious concerns to the environment, biota and human health. Though in silico computational, in vitro mechanistic, pre-clinical animal and clinical human studies showed endocrine disruption, hepatotoxic, teratogenic and carcinogenic properties, usage of phthalates continues due to their cuteness, attractive chemical properties, low production cost and lack of suitable alternatives. Studies revealed that microbes isolated from phthalate-contaminated environmental niches efficiently bioremediate various phthalates. Based upon this background, this review addresses the enumeration of major phthalates used in industry, routes of environmental contamination, evidences for health hazards, routes for in situ and ex situ microbial degradation, bacterial pathways involved in the degradation, major enzymes involved in the degradation process, half-lives of phthalates in environments, etc. Briefly, this handy module would enable the readers, environmentalists and policy makers to understand the impact of phthalates on the environment and the biota, coupled with the concerted microbial efforts to alleviate the burden of ever increasing load posed by phthalates.

  9. A MONOGRAPH OF THE GENUS NEESIA * Blume (Bombacaceae

    Directory of Open Access Journals (Sweden)

    SOEPADMO SOEPADMO

    2014-01-01

    Full Text Available 1     Eight species are described:  N. altissima, synandra, glabra, koster-mansiana, malayana, parpurascens, piluliflora and strigosa.2     N. kostermansiana is a species new to science.3     N. glabra and synandra, formerly included in N. altissima are reinstated  as distinct species.4     The area of distribution of the genus covers Lower Siam, the Malay Peninsula, Sumatra, Java and Borneo, with Borneo as centre.

  10. IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans

    NARCIS (Netherlands)

    Pearce, Neil E; Blair, Aaron; Vineis, Paolo; Ahrens, Wolfgang; Andersen, Aage; Anto, Josep M; Armstrong, Bruce K; Baccarelli, Andrea A; Beland, Frederick A; Berrington, Amy; Bertazzi, Pier A; Birnbaum, Linda S; Brownson, Ross C; Bucher, John R; Cantor, Kenneth P; Cardis, Elisabeth; Cherrie, John W; Christiani, David C; Cocco, Pierluigi; Coggon, David; Comba, Pietro; Demers, Paul A; Dement, John M; Douwes, Jeroen; Eisen, Ellen A; Engel, Lawrence S; Fenske, Richard A; Fleming, Lora E; Fletcher, Tony; Fontham, Elizabeth; Forastiere, Francesco; Frentzel-Beyme, Rainer; Fritschi, Lin; Gerin, Michel; Goldberg, Marcel; Grandjean, Philippe; Grimsrud, Tom K; Gustavsson, Per; Haines, Andy; Hartge, Patricia; Hansen, Johnni; Hauptmann, Michael; Heederik, Dick; Hemminki, Kari; Hemon, Denis; Hertz-Picciotto, Irva; Hoppin, Jane A; Huff, James; Jarvholm, Bengt; Kang, Daehee; Karagas, Margaret R; Kjaerheim, Kristina; Kjuus, Helge; Kogevinas, Manolis; Kriebel, David; Kristensen, Petter; Kromhout, Hans; Laden, Francine; Lebailly, Pierre; LeMasters, Grace; Lubin, Jay H; Lynch, Charles F; Lynge, Elsebeth; 't Mannetje, Andrea; McMichael, Anthony J; McLaughlin, John R; Marrett, Loraine; Martuzzi, Marco; Merchant, James A; Merler, Enzo; Merletti, Franco; Miller, Anthony; Mirer, Franklin E; Monson, Richard; Nordby, Karl-Kristian; Olshan, Andrew F; Parent, Marie-Elise; Perera, Frederica P; Perry, Melissa J; Pesatori, Angela C; Pirastu, Roberta; Porta, Miquel; Pukkala, Eero; Rice, Carol; Richardson, David B; Ritter, Leonard; Ritz, Beate; Ronckers, Cecile M; Rushton, Lesley; Rusiecki, Jennifer A; Rusyn, Ivan; Samet, Jonathan M; Sandler, Dale P; de Sanjose, Silvia; Schernhammer, Eva; Seniori Constantini, Adele; Seixas, Noah; Shy, Carl; Siemiatycki, Jack; Silvermann, Debra T; Simonato, Lorenzo; Smith, Allan H; Smith, Martyn T; Spinelli, John J; Spitz, Margaret R; Stallones, Lorann; Stayner, Leslie T; Steenland, Kyle; Stenzel, Mark; Stewart, Bernard W; Stewart, Patricia A; Symanski, Elaine; Terracini, Benedetto; Tolbert, Paige E; Vainio, Harri; Vena, John; Vermeulen, Roel; Victora, Cesar G; Ward, Elizabeth M; Weinberg, Clarice R; Weisenburger, Dennis; Wesseling, Catharina; Weiderpass, Elisabete; Zahm, Shelia H

    2015-01-01

    BACKGROUND: Recently the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also the approach used to perform these evaluations. Some critics have claimed that IARC Working Groups' fa

  11. Consumer Education in the English Curriculum. Monograph 5.

    Science.gov (United States)

    Greenspan, Nancy B.; Johnston, William L.

    Consumer education should be integrated throughout the curriculum in an inter-disciplinary manner. English teachers have unparalleled opportunity to provide students with excellent foundations for critical and interpretive reading and thinking in the area of advertising, as they are involved with reading, vocabulary building, and both oral and…

  12. State Defense Force Monograph Series. Fall 2007, Special Units

    Science.gov (United States)

    2007-01-01

    authors and the visual panorama of artists and film makers. Those World War Two soldiers for whom “taps” has not yet been sounded may still remember the...is a reenactor and living historian, with an emphasis on mounted cavalry, formed and commanded many reenactment units, trained numerous soldiers in

  13. IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans

    NARCIS (Netherlands)

    Pearce, Neil E; Blair, Aaron; Vineis, Paolo; Ahrens, Wolfgang; Andersen, Aage; Anto, Josep M; Armstrong, Bruce K; Baccarelli, Andrea A; Beland, Frederick A; Berrington, Amy; Bertazzi, Pier A; Birnbaum, Linda S; Brownson, Ross C; Bucher, John R; Cantor, Kenneth P; Cardis, Elisabeth; Cherrie, John W; Christiani, David C; Cocco, Pierluigi; Coggon, David; Comba, Pietro; Demers, Paul A; Dement, John M; Douwes, Jeroen; Eisen, Ellen A; Engel, Lawrence S; Fenske, Richard A; Fleming, Lora E; Fletcher, Tony; Fontham, Elizabeth; Forastiere, Francesco; Frentzel-Beyme, Rainer; Fritschi, Lin; Gerin, Michel; Goldberg, Marcel; Grandjean, Philippe; Grimsrud, Tom K; Gustavsson, Per; Haines, Andy; Hartge, Patricia; Hansen, Johnni; Hauptmann, Michael; Heederik, Dick|info:eu-repo/dai/nl/072910542; Hemminki, Kari; Hemon, Denis; Hertz-Picciotto, Irva; Hoppin, Jane A; Huff, James; Jarvholm, Bengt; Kang, Daehee; Karagas, Margaret R; Kjaerheim, Kristina; Kjuus, Helge; Kogevinas, Manolis; Kriebel, David; Kristensen, Petter; Kromhout, Hans|info:eu-repo/dai/nl/074385224; Laden, Francine; Lebailly, Pierre; LeMasters, Grace; Lubin, Jay H; Lynch, Charles F; Lynge, Elsebeth; 't Mannetje, Andrea; McMichael, Anthony J; McLaughlin, John R; Marrett, Loraine; Martuzzi, Marco; Merchant, James A; Merler, Enzo; Merletti, Franco; Miller, Anthony; Mirer, Franklin E; Monson, Richard; Nordby, Karl-Kristian; Olshan, Andrew F; Parent, Marie-Elise; Perera, Frederica P; Perry, Melissa J; Pesatori, Angela C; Pirastu, Roberta; Porta, Miquel; Pukkala, Eero; Rice, Carol; Richardson, David B; Ritter, Leonard; Ritz, Beate; Ronckers, Cecile M; Rushton, Lesley; Rusiecki, Jennifer A; Rusyn, Ivan; Samet, Jonathan M; Sandler, Dale P; de Sanjose, Silvia; Schernhammer, Eva; Seniori Constantini, Adele; Seixas, Noah; Shy, Carl; Siemiatycki, Jack; Silvermann, Debra T; Simonato, Lorenzo; Smith, Allan H; Smith, Martyn T; Spinelli, John J; Spitz, Margaret R; Stallones, Lorann; Stayner, Leslie T; Steenland, Kyle; Stenzel, Mark; Stewart, Bernard W; Stewart, Patricia A; Symanski, Elaine; Terracini, Benedetto; Tolbert, Paige E; Vainio, Harri; Vena, John; Vermeulen, Roel|info:eu-repo/dai/nl/216532620; Victora, Cesar G; Ward, Elizabeth M; Weinberg, Clarice R; Weisenburger, Dennis; Wesseling, Catharina; Weiderpass, Elisabete; Zahm, Shelia H

    2015-01-01

    BACKGROUND: Recently the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also the approach used to perform these evaluations. Some critics have claimed that IARC Working Groups'

  14. "A Limited Number of Advertising Pages." Journalism Monographs, No. 25.

    Science.gov (United States)

    Garberson, John W.

    This report provides information on the background against which the "Readers Digest" began to carry advertising in the United States, the implementation of the decision to do so, the evolution from accepting ads to selling space aggressively, and the performance of the magazine's advertising sales forces as of early 1972. The…

  15. I. Monographic Section Constructing territories/constructing identity. Lagoons compared

    Directory of Open Access Journals (Sweden)

    Sauro Gelichi (a cura di

    2015-10-01

    Though fragmented and tied to the specificity of the single contributions, the picture that emerges is one moving towards the construction of a unitary interpretative paradigm, in which the constructed territory is analysed in all its forms and expressions, both material and ideological. The result is an original and in some ways unique story of a significant segment of early medieval Italian history that has until now been largely neglected by historical studies.

  16. Demography and Educational Planning. Monograph Series No. 7.

    Science.gov (United States)

    Macleod, Betty, Ed.

    The OISE Educational Planning Department launched a research program to determine the current patterns of fertility and migration of the Ontario population, with a view to subsequent investigations into the interrelationships between population growth and shift and education. Demographers and educators engaged in demographic research related to…

  17. Methadone Diversion: Experiences and Issues. Services Research Monograph Series.

    Science.gov (United States)

    Inciardi, James A.

    This report is a description of the phenomenon of methadone diversion as it exists now and places it in the context of prior research in this area. The intent here is to clarify issues around methadone diversion and to provide guidance to treatment administrators and program planners regarding efforts they can initiate to monitor this significant…

  18. Chemical Vapor Deposited Zinc Sulfide. SPIE Press Monograph

    Energy Technology Data Exchange (ETDEWEB)

    McCloy, John S.; Tustison, Randal W.

    2013-04-22

    Zinc sulfide has shown unequaled utility for infrared windows that require a combination of long-wavelength infrared transparency, mechanical durability, and elevated-temperature performance. This book reviews the physical properties of chemical vapor deposited ZnS and their relationship to the CVD process that produced them. An in-depth look at the material microstructure is included, along with a discussion of the material's optical properties. Finally, because the CVD process itself is central to the development of this material, a brief history is presented.

  19. Property and Business Services. Industry Training Monograph No. 12.

    Science.gov (United States)

    Dumbrell, Tom

    Australia's property and business services industry is its third largest industry and has been the fastest growing industry over the last 10 years. The industry is composed of a diverse range of activities, including real estate sales, legal and accountancy practices, employment placement services, labor and equipment hire, scientific and market…

  20. Electricity, Gas and Water Supply. Industry Training Monograph No. 4.

    Science.gov (United States)

    Dumbrell, Tom

    Australia's electricity, gas, and water supply industry employs only 0.8% of the nation's workers and employment in the industry has declined by nearly 39% in the last decade. This industry is substantially more dependent on the vocational education and training (VET) sector for skilled graduates than is the total Australian labor market. Despite…

  1. Transport and Storage. Industry Training Monograph No. 9.

    Science.gov (United States)

    Dumbrell, Tom

    Australia's transport and storage industry is a large, diverse sector covering all forms of transport operation, including road, rail, air, and sea, and related services: stevedoring, port operations, customs agencies, and travel agencies. Employment in this industry has not grown as quickly over the last decade as employment in general. Under…

  2. Property and Business Services. Industry Training Monograph No. 12.

    Science.gov (United States)

    Dumbrell, Tom

    Australia's property and business services industry is its third largest industry and has been the fastest growing industry over the last 10 years. The industry is composed of a diverse range of activities, including real estate sales, legal and accountancy practices, employment placement services, labor and equipment hire, scientific and market…

  3. Accommodation, Cafes and Restaurants. Industry Training Monograph No. 8.

    Science.gov (United States)

    Dumbrell, Tom

    Australia's accommodation, cafes, and restaurants industry represents more than half of the nation's total tourism and hospitality employment. It accounts for roughly 4.5% of all jobs in Australia (400,000 workers). Since 1987, the number of jobs in the sector has risen from about 257,000 to about 372,000. Approximately 57% of employees are…

  4. Drug discovery from fungal metabolites: a review of the papers in this monographical issue of Mycosystema concerned with the natural resources, problems and strategies%真菌代谢产物的药物发现——资源、问题和策略

    Institute of Scientific and Technical Information of China (English)

    郑维发

    2011-01-01

    本期菌物学报"真菌生物活性代谢产物的药物发现专刊"刊登了7篇深度论述的综述性文章,19篇研究论文及2篇简报.内容涉及植物内生真菌产紫杉醇/紫杉烷的研究现状及最新进展、虫草菌素产生菌的培养策略及其药理学研究进展、灵芝三萜和胞外多糖生物合成的调控策略、淡水和海水真菌活性代谢产物研究进展等.本期内容还涉及内生真菌的分离和鉴定、海洋真菌的代谢产物分离、大型真菌的培养、代谢产物的分离及其药理学研究、酚类化合物测定方法、蛋白质组学以及生物转化等研究,基本体现了我国真菌代谢产物新药发现研究的最新进展,对真菌代谢产物合成调控、活性代谢产物分离和结构鉴定以及药理学研究等都具有重要的参考价值.%This monographical issue of Mycosystema contains 7 in-depth reviews, 19 research articles and 2 short communications on the latest and most important progress in the resources, problems and strategies for drug discovery from fungal metabolites. It covers the current progress and latest achievements on production of taxol by entophytic fungi, strategies and latest developments on culturing cordycepin-producing fungi, regulation strategies on biosynthesis of triterpenoids and extracellular polysaccharides produced by Ganoderma lucidum, current progress on bioactive metabolites from the fungi grown in fresh and sea water. This issue of Mycosystema also involves the isolation and identification of entophytic fungi, isolation of metabolites from sea-grown fungi, the culture for macro-fungi and isolation and bioassay of their metabolites, and research of methodology on determining polyphenols,proteomics and biotransformation. These reviews and research articles represent the most updated progress in drug discovery from fungal metabolites in China, and provide insights into up-regulation of bioactive fungal metabolites, isolation and structure

  5. Developing a Test Collection for the Evaluation of Integrated Search

    DEFF Research Database (Denmark)

    Lykke, Marianne; Larsen, Birger; Lund, Haakon;

    2010-01-01

    he poster discusses the characteristics needed in an information retrieval (IR) test collection to facilitate the evaluation of integrated search, i.e. search across a range of different sources but with one search box and one ranked result list, and describes and analyses a new test collection...... constructed for this purpose. The test collection consists of approx. 18,000 monographic records, 160,000 papers and journal articles in PDF and 275,000 abstracts with a varied set of metadata and vocabularies from the physics domain, 65 topics based on real work tasks and corresponding graded relevance...... assessments. The test collection may be used for systems- as well as user-oriented evaluation....

  6. Installation Restoration Program. Phase 1: Records Search, Sheppard AFB, Texas

    Science.gov (United States)

    1984-02-01

    Treatment Technology, W.V. Eckenfelder and J.W. Patterson, ed., 1981. A-5 Eric H. Snider (Continued) Manning, F.S., and E.H. Snider; "Oil aia Grease...Removal by Gravity,0 Invited Monograph in Series on Wastewater Treatment Technology, W.W. Eckenfelder and J.W. Patterson, ed., 1981. Manning, F.S., and E.H...Snider; "Incineration: Wastewater Treatment Applications,s Invited Monograph in Series on Wastewater Treatment Technology, W.W. Eckenfelder and J.W

  7. Additions to our monograph on Psathyrella. Thirteen new species, some revised keys, comments on other recently described species, and corrections and additions to our monograph

    NARCIS (Netherlands)

    Kits van Waveren, E.

    1987-01-01

    Thirteen new species and a new variety of Psathyrella are described: P. badia, P. bernhardii, P. borgensis, P. capitatocystis, P. dennyensis, P. minutissima, P. mookensis, P. multicystidiata, P. perpusilla, P. ploddensis, P. romseyensis, P. twickelensis, P. vyrnwyensis, and P. obtusata var.

  8. Priorities in Dealing with Nutrition Problems in Indonesia. Cornell International Nutrition Monograph Series, Number 1 (1974).

    Science.gov (United States)

    Soekirman

    A study of the literature dealing with past and present food and nutrition problems in Indonesia reveals that the problems remain serious. The major nutrition problems are: (1) Protein-Calorie Malnutrition; (2) Vitamin A Deficiency; (3) Nutritional Anemia; and (4) Goitre. These nutrition problems afflict people of all ages, males and females.…

  9. Use of political pressure as a policy tool during the 1979 oil-supply crisis. [Monograph

    Energy Technology Data Exchange (ETDEWEB)

    Erfle, S.; Pound, J.; Kalt, J.

    1981-01-01

    The response of American markets to supply crisis in world oil markets is analyzed in the context of four main issues: the efficiency of the operation of American oil markets during oil-supply crises; the problems of both economic efficiency and social equity that arise during the American adaptation process; the propriety of the federal government's past policy responses to these problems; and the relationship between perceptions of the problems caused by world oil crises and the real economic nature of these problems. The conclusion is reached that federal intervention has caused the bulk of the genuine oil-market inefficiencies experienced by American consumers since 1973, and has forced major oil companies in particular into price and supply behavior at odds with the interests of the firms themselves and society's interests in maximizing national economic output. 64 references, 15 figures, 11 tables.

  10. Patterns of Living in California's Migrant Labor Families. Research Monograph No. 12.

    Science.gov (United States)

    Hawkes, Glenn R.; And Others

    This report presents a study of the living patterns of California's migrant labor families, one part of a national study on the identification of life patterns among relatively disadvantaged families. Data were collected from 169 interviews with homemakers randomly selected from 12 state-owned migrant camps in California. The interviews consisted…

  11. Individual and Distributed Cognitions in Interdisciplinary Teamwork: A Developing Case Study and Emerging Theory. Research Monograph.

    Science.gov (United States)

    Derry, Sharon J.; DuRussel, Lori Adams; O'Donnell, Angela M.

    We present a developing distributed cognition theory of interdisciplinary collaboration that incorporates concepts from both situated cognition and information processing theory. This theoretical framework is being refined as it is used for analyzing interdisciplinary collaboration within the National Institute of Science Education (NISE). The…

  12. Freedom of the Press in Europe, 1815-1914. Journalism Monographs Number Eighty.

    Science.gov (United States)

    Goldstein, Robert J.

    In 19th century Europe, the dominant classes detested the idea of a free press, seeing it as a middle and lower class weapon. Although repression of the press in Europe existed long before the 19th century, at this time techniques of press repression fell into two major categories: (1) direct--licensing, prior censorship, and post-publication…

  13. A Bibliography of Philippine Language Dictionaries and Vocabularies. Special Monograph Issue, Number 30.

    Science.gov (United States)

    Hendrickson, Gail R., Comp.; Newell, Leonard E., Comp.

    This bibliography is a comprehensive listing of dictionaries and vocabularies, published and unpublished, of the Philippine languages. Introductory sections chronicle briefly the histories of Philippine lexicography and Philippine bibliographies, describe the scope of the present work, and outline the organization of the bibliography itself and…

  14. Glosario de Tecnologia Educativa. Monografia No. 1 (Glossary of Educational Technology. Monograph No. 1).

    Science.gov (United States)

    Chadwick, Clifton; Rojas, Alicia Mabel

    This glossary offers definitions of almost 600 terms normally associated with the field of educational technology in brief and easy-to-understand form, all in Spanish (a Portugese version exists). The terms are organized into six major areas: learning, communications, instructional design, evaluation, media production, and systems theory. (Author)

  15. Behavior Modification and Transfer in an Out-of-Control Classroom. Monograph Number 5.

    Science.gov (United States)

    Orme, Michael E. J.; Purnell, Richard F.

    Three hypotheses were tested in this 6-week study: a) training in systematic application of strategies designed to reinforce desirable pupil behavior would enable the teacher to develop and maintain classroom control and increase pupil learning; b) desirable pupil behavior thus produced could be transferred from one classroom to another in which…

  16. Literacy Assessment for Today's Schools. Monograph of the College Reading Association.

    Science.gov (United States)

    Collins, Martha D., Ed.; Moss, Barbara G., Ed.

    This collection of 17 papers provides a blueprint for teachers who want increasingly sophisticated methods for monitoring student growth and can serve as a resource for in-service educators as literacy instruction changes. Papers in the first section of the book examine literacy assessment as it pertains to school-age children. Papers in the…

  17. State Defense Force Monograph Series: Mission Growth of the SDF from the Cold War

    Science.gov (United States)

    2009-01-01

    as pre-placed and “walk-in” explosive devices; our critical infrastructure is vulnerable to all forms of interruption and destruction by external...knowledge that the nation was not prepared for Pearl Harbor; it was not prepared for the first attack on the World Trade Center ( WTC ), nor was it prepared...for the subsequent attacks of 9-11 on the WTC and the Pentagon. What will it take to move us from business as usual to a point of realization that

  18. Organizing for Student Success: The University College Model. The First Year Experience Monograph Series No. 53

    Science.gov (United States)

    Evenbeck, Scott E.; Jackson, Barbara; Smith, Maggy; Ward, Dorothy

    2010-01-01

    Organizing for Student Success draws on data from more than 50 institutions to provide insight into how university colleges are organized, the initiatives they house, and the practices in place to ensure their effectiveness. Twenty case studies from 15 different campuses offer an in-depth understanding of institutional practice. Ultimately,…

  19. Taxation and regulation of petroleum companies under asymmetric information; a monograph

    Energy Technology Data Exchange (ETDEWEB)

    Osmundsen, P.

    1994-12-01

    The report relates to the taxation and regulation of petroleum companies. The main topics of this report are as follow: Taxation and regulation of petroleum companies under asymmetric information. A discussion of incentive problems and the principles for applying principal-agent analysis; taxation and regulation of petroleum companies under asymmetric information. A static adverse selection model; Petroleum Taxation with adverse selection. Interactions of dynamics in costs and information; Adverse selection and moral hazard in the petroleum industry, repeated auctions of incentive contracts; Petroleum taxation and regulation. Policy implications from principal-agent theory, and a comparison with the current Norwegian system. 54 refs., 7 figs.

  20. Citations and Circulation Counts: Data Sources for Monograph Deselection in Research Library Collections

    Science.gov (United States)

    White, Bruce

    2017-01-01

    Studies of data-driven deselection overwhelmingly emphasise the importance of circulation counts and date-of-last-use in the weeding process. When applied to research collections, however, this approach fails to take account of highly influential and significant titles that have not been of interest to large numbers of borrowers but that have been…

  1. A MONOGRAPH OF THE GENUS PARINARI Aubl. (Rosaceae-Chrysobalanoideae IN ASIA AND THE PACIFIC REGION

    Directory of Open Access Journals (Sweden)

    A. J. G. H. KOSTERMANS

    2015-11-01

    Full Text Available In the area 20 species (one cultivated are recognized; furthermore oneundescribed species is discussed.The genera Cyelaiulrophora Hassk. and Mara/tithes Bl. are segregated fromParinari proper.The genus is subdivided into 2 sections: Parinari and Anareolala.

  2. Biowaiver monographs for immediate release solid oral dosage forms: ethambutol dihydrochloride.

    Science.gov (United States)

    Becker, C; Dressman, J B; Amidon, G L; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2008-04-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing ethambutol dihydrochloride as the only active pharmaceutical ingredient (API) are reviewed. Ethambutol dihydrochloride is a Biopharmaceutics Classification System (BCS) Class III drug with permeability properties approaching the border between BCS Class I and III. BE problems of ethambutol formulations containing different excipients and different dosages forms have not been reported and hence the risk of bioinequivalence caused by excipients is low. Ethambutol has a narrow therapeutic index related to ocular toxicity. However, as long as the prescribers' information of the test product stipulates the need for regular monitoring of ocular toxicity, the additional patient risk is deemed acceptable. It is concluded that a biowaiver can be recommended for IR solid oral dosage forms provided that the test product (a) contains only excipients present in ethambutol IR solid oral drug products approved in ICH or associated countries, for instance as presented in this paper, (b) complies with the criteria for "very rapidly dissolving" and (c) has a prescribers' information indicating the need for testing the patient's vision prior to initiating ethambutol therapy and regularly during therapy.

  3. Biowaiver monographs for immediate release solid oral dosage forms: quinidine sulfate.

    Science.gov (United States)

    Grube, S; Langguth, P; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2009-07-01

    Literature data are reviewed relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of new multisource and reformulated immediate release (IR) solid oral dosage forms containing quinidine sulfate. Quinidine sulfate's solubility and permeability, its therapeutic use and index, pharmacokinetics, excipient interactions and reported BE/bioavailability (BA) problems were taken into consideration. The available data are not fully conclusive, but do suggest that quinidine sulfate is highly soluble and moderately to highly permeable and would likely be assigned to BCS Class I (or at worst BCS III). In view of the inconclusiveness of the data and, more important, quinidine's narrow therapeutic window and critical indication, a biowaiver based approval of quinidine containing dosage forms cannot be recommended for either new multisource drug products or for major postapproval changes (variations) to existing drug products.

  4. Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Nifedipine.

    Science.gov (United States)

    Gajendran, Jayachandar; Krämer, Johannes; Shah, Vinod P; Langguth, Peter; Polli, James; Mehta, Mehul; Groot, D W; Cristofoletti, Rodrigo; Abrahamsson, Bertil; Dressman, Jennifer B

    2015-10-01

    Literature data relevant to the biopharmaceutical properties of the active pharmaceutical ingredient (API) nifedipine are reviewed to evaluate whether a waiver of in vivo bioequivalence (BE) testing of immediate-release (IR) dosage forms formulated as tablets and soft gelatin capsules is warranted. Nifedipine's solubility and permeability, its therapeutic use and index, pharmacokinetics, food drug interactions, and any reported BE/bioavailability problems were all taken into consideration. Solubility and BA data indicate conclusively that nifedipine is a class II substance of biopharmaceutics classification system (BCS) and that the formulation of drug product plays a key role on the dissolution characteristics of the API. Therefore, a BCS biowaiver-based approval of nifedipine containing IR oral dosage forms cannot be recommended for reformulated/new multisource drug products or for major scale-up and postapproval changes to the existing drug products.

  5. Biowaiver monographs for immediate release solid oral dosage forms: ranitidine hydrochloride.

    Science.gov (United States)

    Kortejärvi, H; Yliperttula, M; Dressman, J B; Junginger, H E; Midha, K K; Shah, V P; Barends, D M

    2005-08-01

    Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence testing for the approval of immediate release (IR) solid oral dosage forms containing ranitidine hydrochloride are reviewed. According to the current Biopharmaceutics Classification System (BCS), ranitidine hydrochloride should be assigned to Class III. However, based on its therapeutic and therapeutic index, pharmacokinetic properties and data related to the possibility of excipient interactions, a biowaiver can be recommended for IR solid oral dosage forms that are rapidly dissolving and contain only those excipients as reported in this study.

  6. Biowaiver monographs for immediate release solid oral dosage forms: acetaminophen (paracetamol).

    OpenAIRE

    Kalantzi, L; Reppas, C; Dressman, J B; Amidon, G L; Junginger, H E; Midha, K.K.; Shah, V. P.; Stavchansky, S A; Barends, Dirk M.

    2006-01-01

    Literature data are reviewed on the properties of acetaminophen (paracetamol) related to the biopharmaceutics classification system (BCS). According to the current BCS criteria, acetaminophen is BCS Class III compound. Differences in composition seldom, if ever, have an effect on the extent of absorption. However, some studies show differences in rate of absorption between brands and formulations. In particular, sodium bicarbonate, present in some drug products, was reported to give an increa...

  7. Biowaiver monographs for immediate release solid oral dosage forms: acetaminophen (paracetamol).

    Science.gov (United States)

    Kalantzi, L; Reppas, C; Dressman, J B; Amidon, G L; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S A; Barends, Dirk M

    2006-01-01

    Literature data are reviewed on the properties of acetaminophen (paracetamol) related to the biopharmaceutics classification system (BCS). According to the current BCS criteria, acetaminophen is BCS Class III compound. Differences in composition seldom, if ever, have an effect on the extent of absorption. However, some studies show differences in rate of absorption between brands and formulations. In particular, sodium bicarbonate, present in some drug products, was reported to give an increase in the rate of absorption, probably caused by an effect on gastric emptying. In view of Marketing Authorizations (MAs) given in a number of countries to acetaminophen drug products with rapid onset of action, it is concluded that differences in rate of absorption were considered therapeutically not relevant by the Health Authorities. Moreover, in view of its therapeutic use, its wide therapeutic index and its uncomplicated pharmacokinetic properties, in vitro dissolution data collected according to the relevant Guidances can be safely used for declaring bioequivalence (BE) of two acetaminophen formulations. Therefore, accepting a biowaiver for immediate release (IR) acetaminophen solid oral drug products is considered scientifically justified, if the test product contains only those excipients reported in this paper in their usual amounts and the test product is rapidly dissolving, as well as the test product fulfils the criterion of similarity of dissolution profiles to the reference product.

  8. Biowaiver monographs for immediate release solid oral dosage forms: diclofenac sodium and diclofenac potassium.

    Science.gov (United States)

    Chuasuwan, B; Binjesoh, V; Polli, J E; Zhang, H; Amidon, G L; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2009-04-01

    Literature data are reviewed regarding the scientific advisability of allowing a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing either diclofenac potassium and diclofenac sodium. Within the biopharmaceutics classification system (BCS), diclofenac potassium and diclofenac sodium are each BCS class II active pharmaceutical ingredients (APIs). However, a biowaiver can be recommended for IR drug products of each salt form, due to their therapeutic use, therapeutic index, pharmacokinetic properties, potential for excipient interactions, and performance in reported BE/bioavailability (BA) studies, provided: (a) test and comparator contain the same diclofenac salt; (b) the dosage form of the test and comparator is identical; (c) the test product contains only excipients present in diclofenac drug products approved in ICH or associated countries in the same dosage form, for instance as presented in this paper; (d) test drug product and comparator dissolve 85% in 30 min or less in 900 mL buffer pH 6.8, using the paddle apparatus at 75 rpm or the basket apparatus at 100 rpm; and (e) test product and comparator show dissolution profile similarity in pH 1.2, 4.5, and 6.8.

  9. Biowaiver monographs for immediate-release solid oral dosage forms: stavudine.

    Science.gov (United States)

    Silva, Arthur L L; Cristofoletti, Rodrigo; Storpirtis, Silvia; Sousa, Varley D; Junginger, Hans E; Shah, Vinod P; Stavchansky, Salomon; Dressman, Jennifer B; Barends, Dirk M

    2012-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing stavudine (d4T) are reviewed. According to Biopharmaceutics Classification System (BCS), d4T can be assigned to BCS class I. No problems with BE of IR d4T formulations containing different excipients and produced by different manufacturing methods have been reported and, hence, the risk of bioinequivalence caused by these factors appears to be low. Furthermore, d4T has a wide therapeutic index. It is concluded that a biowaiver is appropriate for IR solid oral dosage forms containing d4T as the single active pharmaceutical ingredient (API) provided that (a) the test product contains only excipients present in the IR d4T drug products that have been approved in a number of countries for the same dosage form, and (b) both test product and its comparator are either "very rapidly dissolving" or "rapidly dissolving" with similarity of dissolution profiles demonstrated at pH 1.2, 4.5, and 6.8.

  10. Biowaiver monographs for immediate release solid oral dosage forms: ciprofloxacin hydrochloride.

    Science.gov (United States)

    Olivera, M E; Manzo, R H; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2011-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of new multisource and reformulated immediate release (IR) solid oral dosage forms containing ciprofloxacin hydrochloride as the only active pharmaceutical ingredient (API) are reviewed. Ciprofloxacin hydrochloride's solubility and permeability, its therapeutic use and index, pharmacokinetics, excipient interactions and reported BE/bioavailability (BA) problems were taken into consideration. Solubility and BA data indicate that ciprofloxacin hydrochloride is a BCS Class IV drug. Therefore, a biowaiver based approval of ciprofloxacin hydrochloride containing IR solid oral dosage forms cannot be recommended for either new multisource drug products or for major scale-up and postapproval changes (variations) to existing drug products.

  11. Biowaiver monographs for immediate release solid oral dosage forms: Doxycycline hyclate.

    Science.gov (United States)

    Jantratid, E; Strauch, S; Becker, C; Dressman, J B; Amidon, G L; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2010-04-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing doxycycline hyclate are reviewed. According to the Biopharmaceutics Classification System (BCS), doxycycline hyclate can be assigned to BCS Class I. No problems with BE of IR doxycycline formulations containing different excipients and produced by different manufacturing methods have been reported and hence the risk of bioinequivalence caused by these factors appears to be low. Doxycycline has a wide therapeutic index. Further, BCS-based dissolution methods have been shown to be capable of identifying formulations which may dissolve too slowly to generate therapeutic levels. It is concluded that a biowaiver is appropriate for IR solid oral dosage forms containing doxycycline hyclate as the single Active Pharmaceutical Ingredient (API) provided that (a) the test product contains only excipients present in doxycycline hyclate IR solid oral drug products approved in the International Conference on Harmonization (ICH) or associated countries; and (b) the comparator and the test products comply with the BCS criteria for "very rapidly dissolving" or, alternatively, when similarity of the dissolution profiles can be demonstrated and the two products are "rapidly dissolving.".

  12. Biowaiver monographs for immediate release solid oral dosage forms: amitriptyline hydrochloride.

    Science.gov (United States)

    Manzo, R H; Olivera, M E; Amidon, G L; Shah, V P; Dressman, J B; Barends, D M

    2006-05-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing amitriptyline hydrochloride are reviewed. Its therapeutic uses, its pharmacokinetic properties, the possibility of excipient interactions and reported BE/bioavailability (BA) problems are also taken into consideration. Literature data indicates that amitriptyline hydrochloride is a highly permeable active pharmaceutical ingredient (API). Data on the solubility according to the current Biopharmaceutics Classification System (BCS) were not fully available and consequently amitriptyline hydrochloride could not be definitively assigned to either BCS Class I or BCS Class II. But all evidence taken together, a biowaiver can currently be recommended provided that IR tablets are formulated with excipients used in existing approved products and that the dissolution meets the criteria defined in the Guidances.

  13. Biowaiver monographs for immediate release solid oral dosage forms: acetaminophen (paracetamol).

    NARCIS (Netherlands)

    Kalantzi, L; Reppas, C; Dressman, J B; Amidon, G L; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S A; Barends, Dirk M

    2006-01-01

    Literature data are reviewed on the properties of acetaminophen (paracetamol) related to the biopharmaceutics classification system (BCS). According to the current BCS criteria, acetaminophen is BCS Class III compound. Differences in composition seldom, if ever, have an effect on the extent of absor

  14. Biowaiver monographs for immediate release solid oral dosage forms: metoclopramide hydrochloride.

    Science.gov (United States)

    Stosik, A G; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2008-09-01

    Literature data are reviewed relevant to the decision for a biowaiver of immediate release (IR) solid oral dosage forms containing metoclopramide hydrochloride. In addition, new solubility data, obtained under Biopharmaceutics Classification System (BCS) conditions are presented. Metoclopramide HCl is conservatively assigned to BCS Class III. Taken also into consideration excipient interactions reported in metoclopramide drug products, its pharmacokinetic properties and therapeutic use and therapeutic index, a biowaiver can be recommended when: (a) the test product contains only excipients present also in metoclopramide HCl containing IR solid oral drug products approved in ICH or associated countries, for instance as presented in this paper, (b) in amounts in normal use in IR solid oral dosage forms, and (c) the test product and the comparator both comply with the criteria for very rapidly dissolving.

  15. Biowaiver monographs for immediate release solid oral dosage forms: mefloquine hydrochloride.

    Science.gov (United States)

    Strauch, S; Jantratid, E; Dressman, J B; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2011-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release solid oral dosage forms containing mefloquine hydrochloride as the only active pharmaceutical ingredient (API) are reviewed. The solubility and permeability data of mefloquine hydrochloride as well as its therapeutic use and therapeutic index, its pharmacokinetic properties, data related to the possibility of excipient interactions and reported BE/bioavailability studies were taken into consideration. Mefloquine hydrochloride is not a highly soluble API. Since no data on permeability are available, it cannot be classified according to the Biopharmaceutics Classification System with certainty. Additionally, several studies in the literature failed to demonstrate BE of existing products. For these reasons, the biowaiver cannot be justified for the approval of new multisource drug products containing mefloquine hydrochloride. However, scale-up and postapproval changes (HHS-FDA SUPAC) levels 1 and 2 and most EU type I variations may be approvable without in vivo BE, using the dissolution tests described in these regulatory documents.

  16. Biowaiver monographs for immediate-release solid oral dosage forms: primaquine phosphate.

    Science.gov (United States)

    Nair, Anita; Abrahamsson, Bertil; Barends, Dirk M; Groot, D W; Kopp, Sabine; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2012-03-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing the antimalarial drug primaquine phosphate as the only active pharmaceutical ingredient (API) are reviewed. On the basis of permeability data and solubility studies, primaquine phosphate was found to be "highly soluble" and "highly permeable" API, thus conforming to Class I of the Biopharmaceutical Classification System (BCS). It has a wide therapeutic index. BCS-conform dissolution studies showed the products to be rapidly dissolving. No data pertaining to BE or bioinequivalence of IR primaquine phosphate products could be located in open literature. On the basis of the available data, a biowaiver-procedure-based approval can be recommended for IR solid oral dosage forms of primaquine phosphate, provided the generic product contains excipients present in products already approved by the International Conference on Harmonisation or associated countries in similar amounts and the test and reference products meet the dissolution criteria for "rapidly dissolving" (>85% drug release in 30 min in standard media at pH 1.2, 4.5, and 6.8; similarity factor (f(2)) > 50) or "very rapidly dissolving" products (>85% drug release in 15 min in standard media at pH 1.2, 4.5, and 6.8).

  17. Poverty, Equity and Access to Education in Bangladesh. CREATE Pathways to Access. Research Monograph No. 51

    Science.gov (United States)

    Hossain, Altaf; Zeitlyn, Benjamin

    2010-01-01

    Bangladesh has made great improvements in the scale and quality of access to education in recent years and gender equality has almost been achieved in primary education (World Bank, 2008). Evidence from CREATE's nationwide community and school survey (ComSS) confirms results from other research (such as Al-Samarrai, 2009) which suggests that…

  18. Real exchange-rate adjustment and the welfare effects of oil-price decontrol. [Monograph

    Energy Technology Data Exchange (ETDEWEB)

    Krugman, P.

    1981-01-01

    Conventional analysis of the welfare effects of US oil price regulation in the 1970s focuses on the deadweight losses in the oil market. This paper argues that such analysis substantially underrates the benefits from decontrolling prices because decontrol will lead to an improvement in the US terms of trade with respect to other oil-importing countries. A simple model of the relationship between oil decontrol and the terms of trade is developed, and the impact is calculated for plausible parameter values. The results suggest that the terms of trade benefits are several times larger than the benefits as conventionally measured. 4 references, 1 figure, 5 tables.

  19. Teenage Pregnancy: Educational Programs To Promote Self-Sufficiency. Monograph. Volume 1, Number 2.

    Science.gov (United States)

    Saravalli, Susan K.

    The seriousness of the consequences of teenage pregnancy and parenthood results in substantial long-term costs to the public as well as immeasurable personal implications. Education may be one way to combat the deleterious effects. Since attendance at school seems to be the avenue for acquiring the necessary knowledge and skills to become…

  20. Safety in Individual and Dual Sports. Sports Safety Series. Monograph No. 4.

    Science.gov (United States)

    Borozne, Joseph, Ed.; And Others

    The prevention of injuries and control of hazards in individual and dual sports is outlined. A separate chapter is devoted to each of twelve sports: archery, bowling, equitation, golf, gymnastics, marksmanship, track and field, weight training and weight lifting, fencing, racquet sports, judo, and wrestling. (MM)

  1. News Bias in the 1972 Campaign: A Cross-Media Comparison. Journalism Monographs No. 58.

    Science.gov (United States)

    Hofstetter, C. Richard

    The television networks nightly news coverage of the 1972 Presidential campaign was examined between July 10 and November 6, 1972 to assess the nature and impact of political bias in news coverage. The campaign news coverage of two newspapers and one wire service was also compared with respect to the content and length of each medium's news about…

  2. The equilibrium theory of inhomogeneous polymers (international series of monographs on physics)

    CERN Document Server

    Fredrickson, Glenn

    2013-01-01

    The Equilibrium Theory of Inhomogeneous Polymers provides an introduction to the field-theoretic methods and computer simulation techniques that are used in the design of structured polymeric fluids. By such methods, the principles that dictate equilibrium self-assembly in systems ranging from block and graft copolymers, to polyelectrolytes, liquid crystalline polymers, and polymer nanocomposites can be established. Building on an introductory discussion of single-polymer statistical mechanics, the book provides a detailed treatment of analytical and numerical techniques for addressing the conformational properties of polymers subjected to spatially-varying potential fields. This problem is shown to be central to the field-theoretic description of interacting polymeric fluids, and models for a number of important polymer systems are elaborated. Chapter 5 serves to unify and expound the topic of self-consistent field theory, which is a collection of analytical and numerical techniques for obtaining solutions o...

  3. JTEC monograph on biodegradable polymers and plastics in Japan: Research, development, and applications

    Science.gov (United States)

    Lenz, Robert W.

    1995-01-01

    A fact-finding team of American scientists and engineers visited Japan to assess the status of research and development and applications in biodegradable polymers. The visit was sponsored by the National Science Foundation and industry. In Japan, the team met with representatives of 31 universities, government ministries and institutes, companies, and associations. Japan's national program on biodegradable polymers and plastics evaluates new technologies, testing methods, and potential markets for biodegradables. The program is coordinated by the Biodegradable Plastics Society of Japan, which seeks to achieve world leadership in biodegradable polymer technology and identify commercial opportunities for exploiting this technology. The team saw no major new technology breakthroughs. Japanese scientists and engineers are focusing on natural polymers from renewable resources, synthetic polymers, and bacterially-produced polymers such as polyhydroxyalkanoates, poly(amino acids), and polysaccharides. The major polymers receiving attention are the Zeneca PHBV copolymers, Biopol(registered trademark), poly(lactic acid) from several sources, polycaprolactone, and the new synthetic polyester, Bionolle(registered trademark), from Showa High Polymer. In their present state of development, these polymers all have major deficiencies that inhibit their acceptance for large-scale applications.

  4. Training and Entry Into Union Construction. R and D Monograph 39.

    Science.gov (United States)

    Marshall, Ray; And Others

    The study focuses on the issue of entry into building trades unions, detailing union procedures and standards, journeyman's background, and comparing training routes. Various basic construction trades were investigated: bricklayers, carpenters, electrical workers, ironworkers, plumbers and steamfitters, and sheet metal workers. Data were collected…

  5. Clinical roundtable monograph: a multidisciplinary approach to the use of oncotype DX in clinical practice.

    Science.gov (United States)

    Gradishar, William J; Hansen, Nora M; Susnik, Barbara

    2009-04-01

    Recently, recommendations for the use of the Oncotype DX assay in estrogen receptor-positive node-negative breast cancer patients were incorporated into guidelines from both the American Society of Clinical Oncology and the National Comprehensive Cancer Network. The Oncotype DX assay is a diagnostic test which measures changes in a set of 21 genes in order to predict the likelihood of disease recurrence and also to predict which patients are most likely to respond to chemotherapy. Oncotype DX has been available commercially since January 2004 and has been used for more than 85,000 patients. Drs. William J. Gradishar, Nora M. Hansen, and Barbara Susnik answered questions regarding the incorporation of the Oncotype DX breast cancer assay into routine clinical practice. This expert dialog offers an update and clinical insights into when, how, and why clinicians might incorporate the Oncotype DX assay into the management of their breast cancer patients. Also, the latest research into the benefit of the Oncotype DX assay in node-positive patients is discussed. Finally, sample case studies offer clinically relevant examples of the practical application of the Oncotype DX assay.

  6. Collegiate Aviation Research and Education Solutions to Critical Safety Issues. UNO Aviation Monograph Series. UNOAI Report.

    Science.gov (United States)

    Bowen, Brent, Ed.

    This document contains four papers concerning collegiate aviation research and education solutions to critical safety issues. "Panel Proposal Titled Collegiate Aviation Research and Education Solutions to Critical Safety Issues for the Tim Forte Collegiate Aviation Safety Symposium" (Brent Bowen) presents proposals for panels on the…

  7. Labor Markets, Incentives and Occupational Education. Center Research Monograph No. 3.

    Science.gov (United States)

    Fearn, Robert M.

    Although the major factors determining curriculum mix are known, little has been done to measure the relative importance of each factor. Using the data gathered by questionnaire from North Carolina community colleges and technical institutes, this study tested the hypotheses that local labor market structures influence curricular offerings, and…

  8. Non-Conventional Approaches to Education at the Primary Level. UIE Monographs 14.

    Science.gov (United States)

    Ranaweera, A. Mahinda; And Others

    Nonformal approaches to primary education in developing countries are described in detail in the hope that the discussion will benefit decision makers and planners confronting situations marked by mass rural illiteracy, urban marginalization, employment of young children, and ethnic and cultural differences between minorities and the majority…

  9. Politics and Reality in an American City; The New Orleans School Crisis of 1960. A Monograph.

    Science.gov (United States)

    Inger, Morton

    This study focuses on the reasons why one city, which seemingly was ready to be a leader in racial matters, became instead a center for resistance to school integration. When integration began, the reaction of extremists was so intense and prolonged that the city suffered a near catastrophe. The city's most serious problem was a lack of…

  10. Dynamics of the earth's radiation belts and inner magnetosphere (geophysical monograph series)

    CERN Document Server

    2013-01-01

    Dynamics of the Earth's Radiation Belts and Inner Magnetosphere draws together current knowledge of the radiation belts prior to the launch of Radiation Belt Storm Probes (RPSP) and other imminent space missions, making this volume timely and unique. The volume will serve as a useful benchmark at this exciting and pivotal period in radiation belt research in advance of the new discoveries that the RPSP mission will surely bring. Highlights include the following: a review of the current state of the art of radiation belt science; a complete and up-to-date account of the wave-particle interactions that control the dynamical acceleration and loss processes of particles in the Earth's radiation belts and inner magnetosphere; a discussion emphasizing the importance of the cross-energy coupling of the particle populations of the radiation belts, ring current, and plasmasphere in controlling the dynamics of the inner magnetosphe...

  11. Biowaiver monograph for immediate-release solid oral dosage forms: fluconazole.

    Science.gov (United States)

    Charoo, Naseem; Cristofoletti, Rodrigo; Graham, Alexandra; Lartey, Paul; Abrahamsson, Bertil; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James; Shah, Vinod P; Dressman, Jennifer

    2014-12-01

    Literature data pertaining to the decision to allow a waiver of in vivo bioequivalence (BE) testing requirements for the approval of immediate release (IR) solid oral dosage forms containing fluconazole as the only active pharmaceutical ingredient (API) are reviewed. The decision is based on solubility, dissolution, permeability, therapeutic index, pharmacokinetic parameters, pharmacodynamic properties, and other relevant data. BE/bioavailability (BA) problems and drug-excipients interaction data were also reviewed and taken into consideration. According to the biopharmaceutics classification system (BCS), fluconazole in polymorphic forms II and III is a BCS class I drug and has a wide therapeutic index. BE of test formulations from many different manufacturers containing different excipients confirmed that the risk of bioinequivalence because of formulation and manufacturing factors is low. It was inferred that risk can be further reduced if in vitro studies are performed according to biowaiver guidelines. Thus, it is concluded that a biowaiver can be recommended for fluconazole IR dosage forms if (a) fluconazole is present as polymorphic form II or III or any other form/mixture showing high solubility, (b) the selection of excipients be limited to those found in IR drug products approved in International Conference on Harmonisation (ICH) countries for the same dosage form and used in their usual amounts, and (c) both the test and comparator dosage form are very rapidly dissolving, or, rapidly dissolving throughout the shelf life with similar dissolution profiles at pH 1.2, 4.5, and 6.8.

  12. Strategic Priorities for Improving Access to Quality Education in the Kurdistan Region--Iraq. Monograph

    Science.gov (United States)

    Vernez, Georges; Culbertson, Shelly; Constant, Louay

    2014-01-01

    The Kurdistan Regional Government (KRG) began an ambitious reform of the Kurdistan Region of Iraq's (KRI's) kindergarten through grade 12 (K-12) education system beginning in 2007 in an effort to modernize the curriculum, upgrade school facilities, and raise the quality of instruction. In 2010, RAND was asked to conduct a one-year study to assess…

  13. International Aspects of Environmental Education. Monographs in Environmental Education and Environmental Studies. Volume III.

    Science.gov (United States)

    Perkins, John H., Ed.; And Others

    This document contains four sections which deal with various aspects of international environmental education. Section 1 includes papers that describe environmental education projects and programs in South America, Europe, India, Scotland, the Arab states, and the Sudan. An additional article in this chapter compares the environmental education…

  14. NTP-CERHR monograph on the potential human reproductive and developmental effects of acrylamide.

    Science.gov (United States)

    2005-02-01

    Acrylamide, used in the manufacture of polyacrylamide and grouting agents, is produced during the cooking of foods. Workplace exposure to acrylamide can occur through the dermal and inhalation routes. The objectives of this study were to evaluate the metabolism of acrylamide in humans following oral administration, to compare hemoglobin adduct formation on oral and dermal administration, to measure hormone levels, and to monitor the safety of acrylamide in people exposed under controlled conditions. Prior to conducting exposures in humans, a low-dose study was conducted in rats administered 3 mg/kg 1,2,3-¹³C₃acrylamide by gavage. The study protocol was reviewed and approved by Institute Review Boards both at RTI which performed the sample analysis, and the clinical research center conducting the study. 1,2,3-¹³C₃Acrylamide (AM) was administered in an aqueous solution orally (single dose of 0.5, 1.0,or 3.0 mg/kg) or dermally (3 daily doses of 3.0 mg/kg) to sterile male volunteers. Urine samples (3 mg/kg oral dose) were analyzed for AM metabolites using 13C NMR spectroscopy. Approximately 86 % of the urinary metabolites were derived from GSH conjugation, and excreted as N-acetyl-S-(3-amino-3-oxopropyl)cysteine and its S-oxide.Glycidamide, glycer amide, and low levels of N-acetyl-S-(3-amino-2-hydroxy-3-oxopropyl)cysteine were detected in urine. On oral administration, a linear dose response was observed for N-(2-carbamoylethyl)valine (AAVal) and N-(2-carbamoyl-2-hydroxyethyl)valine (GAVal) in hemoglobin. Dermal administration resulted in lower levels of AAVal and GAVal. This study indicated that humans metabolize acrylamide via glycidamide to a lesser extent than rodents, and dermal uptake was approximately 5%of that observed with oral uptake. Acrylamide is used in the manufacture of water- soluble polymers (European Union,2002). These polymers are then used for wastewater and sludge treatment, paper manufacture, soil stabilization, mining and many other uses (European Union, 2002).Acrylamide is also a chemical intermediate in the manufacture of other monomeric chemicals and used for grouting and preparation of laboratory gels for electrophoresis.Human exposure through these applications is very small (European Union, 2002).Previously, it has been postulated that dermal absorption was the major route of human exposure to acrylamide (European Union, 2002). The magnitude of this dermal absorption is highly relevant as one of the uses of acrylamide based polymers is in the formulation of skin creams (European Union, 2002). Estimates of dermal absorption based on in vitro and rodent studies have ranged from 3% to 100 (European Union,2002). Recently, exposure to acrylamide in a variety of cooked foods has been described(Rosen and Hellen as, 2002; Tareke et al., 2002). Human exposure via this route is substantial, with estimated exposures as high as 70 μg per day proposed (Tareke et al.,2002). Acrylamide is metabolized by two main pathways: glutathione conjugation (Dixit et al.,1982; Edwards, 1975; Hashimoto and Aldridge, 1970; Miller et al., 1982; Sumner et al.,1992), and oxidation to glycidamide (Calleman et al., 1990; Sumner et al., 1992). The metabolism of acrylamide in vivo results in the formation of a number of metabolites.These metabolism of acrylamide in vivo has been investigated by administration of 1,2,3-13C3 acrylamide to rodents, with the detection and quantitation of metabolites by 13 CNMR spectroscopy (Sumner et al., 1999; Sumner et al., 1992; Sumner et al., 2003). The oxidation reaction to glycidamide is catalyzed by cytochrome P450 2E1 in rodents(Sumner et al., 1999). Both acrylamide and glycidamide react with hemoglobin producing a stable adduct which can be measured as an indicator of exposure.Correlations have been made with hemoglobin adducts and neurotoxicity, but there has been no systematic standardization of hemoglobin adducts with dose. Glycidamide is weakly mutagenic in the Salmonella test (Hashimoto and Tanii, 1985). It can react with DNA in vitro to produce a guanine derivative N7-(2-carbamoyl-2-hydroxyethyl)guanine(Gamboa da Costa et al., 2003; Segerback et al., 1995). In vivo, administration of acrylamide to rats and mice produces low levels of N7-(2-carbamoyl-2-hydroxyethyl)guanine (Gamboa da Costa et al., 2003; Segerback et al., 1995).Acrylamide induces a characteristic peripheral neurotoxicity in animals and man(Spencer and Schaumburg, 1974a, b, 1975). This toxicity manifests itself as a distal to proximal loss of nerve function and dying back of cells. Acrylamide also effects rodent reproduction, namely smaller litter size. At elevated acrylamide doses other reproductive effects are seen, likely as a consequence of the neurotoxicity. Acrylamide is carcinogenic in drinking water studies in laboratory rats (Friedman et al.,1995; Johnson et al., 1986). In male rats, it induces tumors of the tunica vaginalis testes and the thyroid, while in females, it induces mammary fibroadenomas and thyroid tumors(Friedman et al., 1995). The mechanism for this tumorigenicity is unclear, although interaction with the dopamine receptor has been postulated as well as genotoxicity (Tyland Friedman, 2003). If the mechanism were genotoxicity, then conversion of acrylamide to glycidamide is directly proportional to carcinogenic activity.Understanding the mechanism of tumorigenicity is important, since conventional risk assessment techniques place the order of magnitude of the risk at approximately 10-3 with exposures of 70 μg/ day.The relative contributions of acrylamide and glycidamide in the mode of action of acrylamide are the subject of debate and current research. Understanding the conversion of acrylamide to glycidamide and differences that may occur between species, exposure route, and dose are important considerations in assessing the risk of the possible effects of acrylamide exposures in the diet, in consumer products, and in the workplace.The primary objectives of this study were to evaluate the conversion of acrylamide to glycidamide in people exposed to acrylamide, and to evaluate the extent of uptake following dermal administration. This was conducted by administering a low dose of 13C labeled acrylamide to volunteers orally or dermally, and by measuring urinary metabolites or hemoglobin adducts derived from the glycidamide pathway and comparing them to metabolites and hemoglobin adducts derived from acrylamide directly. More specifically, we intended to evaluate urinary metabolites and hemoglobin adducts, and to measure hormone levels after exposure to a known dose of acrylamide. As a secondary and no less important objective, we intended to monitor the safety of acrylamide in people exposed under controlled conditions.

  15. Toward a Methodology of Naturalistic Inquiry in Educational Evaluation. CSE Monograph Series in Evaluation, 8.

    Science.gov (United States)

    Guba, Egon G.

    Evaluation is viewed as essential to decision making and social policy development. Since conventional methods have been disappointing or inadequate, naturalistic inquiry (N/I) differs from conventional science in minimizing constraints on antecedent conditions (controls) and on output (dependent variables). N/I is phenomenological rather than…

  16. A Comparative Analysis of the Costs of Substitute Care and Family Based Services. Monograph 2.

    Science.gov (United States)

    Hutchinson, Janet

    Family based services attempt to maintain and strengthen the client family and prevent family dissolution and the placement of a child or several children in substitute care. This study compared programs that serve children and their families in their home. Variances in program costs were attributed to differences in number of casework hours per…

  17. Reschooling and the Global Future: Politics, Economics and the English Experience. Monographs in International Education.

    Science.gov (United States)

    Porter, James

    This book analyzes attempts by governments and international development agencies to neutralize the school as an independent and democratizing institution. The volume contains four chapters and a conclusion. Chapter 1, "The Diminished School," highlights the trend away from the liberal and professionally led systems characteristic of the…

  18. Economic impacts of land development: employment, housing, and property values. [Monograph

    Energy Technology Data Exchange (ETDEWEB)

    Muller, T.

    1976-01-01

    This report examines the effects of land development on three areas of the economy: employment, housing, and wealth. The main objective is to provide local governments with inexpensive methods for estimating the impact of new development on demand for employment and housing. Since both employment and housing effects are regional in nature, regional impacts are also noted. National patterns are shown to provide a basis of comparison between local data and national directions. Most changes in property value tend to occur at the neighborhood level. This is one reason for the comparatively limited interest in this subject at the community or regional level. The three areas examined in this study--employment, housing, and wealth--are viewed as one unit for analysis, since each interacts with the others. Additional employment resulting from industrial, commercial, or other development increases the demand for housing. In turn, changes in housing demand affect the value of the existing housing stock and developable land. Residential construction increases the supply of housing and thus affects both the price of existing dwelling units and potentially the level of inmigration to a community due to expanding employment opportunities. And higher per capita personal income resulting from expanded employment opportunities increases demand for housing. (Although income is not treated separately in this report, its relationship to employment, housing demand, and property value is noted.)

  19. A Decision Structure for Teaching Machines. M.I.T. PRESS Research Monograph, 14.

    Science.gov (United States)

    Smallwood, Richard D.

    The problem of enabling a teaching machine to adapt to the individual characteristics of students in presenting course material has been considered--general outlines of computer algorithms and decision criteria have been formulated. It is assumed that there exists both an ordered set of concepts which comprise the material to be learned and, for…

  20. Developmental Language Disability: Adult Accomplishments of Dyslexic Boys. Hood College Monograph Series, Number 2.

    Science.gov (United States)

    Rawson, Margaret B.

    A longitudinal study was made of 56 boys, a highly homogeneous group from 44 families. All had attended a regular private elementary school for at least 3 years between 1930 and 1937. All were placed in three groups according to their performance on a language learning facility scale. The lowest 20 were rated as dyslexis, with specific…

  1. The Bibliographic Control of Foreign Monographs: A Review and Baseline Study.

    Science.gov (United States)

    Leazer, Gregory H.; Rohdy, Margaret

    1995-01-01

    Discussion of the acquisition of foreign research publications focuses on a study that assessed the extent of bibliographic control of foreign published materials in bibliographic utilities. Highlights include a review of previous studies; sources and quality of bibliographic records; timeliness; and presence of Library of Congress Classification…

  2. Inclusive Education in India: Interpretation, Implementation, and Issues. CREATE Pathways to Access. Research Monograph No. 15

    Science.gov (United States)

    Giffard-Lindsay, Katharine

    2007-01-01

    Children with disabilities are a minority that are not prioritised in the context of education programmes in India, although they are often found in many marginalised groups that are catered for if non-disabled, for example, girls, scheduled tribe, scheduled caste, and other backward caste children. Inclusive education may be a way of merging…

  3. Biowaiver monographs for immediate release solid oral dosage forms: acetaminophen (paracetamol).

    NARCIS (Netherlands)

    Kalantzi, L; Reppas, C; Dressman, J B; Amidon, G L; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S A; Barends, Dirk M

    2006-01-01

    Literature data are reviewed on the properties of acetaminophen (paracetamol) related to the biopharmaceutics classification system (BCS). According to the current BCS criteria, acetaminophen is BCS Class III compound. Differences in composition seldom, if ever, have an effect on the extent of absor

  4. Psychosocial Rehabilitation and Mental Illness: Views from Africa, India, Asia and Australia. Monograph Series, Number 49.

    Science.gov (United States)

    Anthony, William A., Ed.; Wolkon, George H., Ed.

    1990-01-01

    This special journal "Theme" issue presents a collection of papers reflecting the psychiatric practices and community treatment for persons with severe psychiatric disabilities in Asia, Africa, Australia, and India. Some of the papers were presented at the 1988 meeting of the World Association of Psychosocial Rehabilitation (WAPR) in…

  5. Workforce Skills Development and Engagement in Training through Skill Sets. NCVER Monograph Series 11/2012

    Science.gov (United States)

    Mills, John; Crean, David; Ranshaw, Danielle; Bowman, Kaye

    2012-01-01

    There has been some debate over whether skill sets have the capacity to be part of a more flexible skilling solution, one in which vocational education and training (VET) in Australia is enhanced. This proposition is explored using a case study of agrifood students who were enrolled in TAFE NSW Statement of Attainment in Rural Production Studies…

  6. Clinical roundtable monograph. Current treatment options for metastatic breast cancer: what now?

    Science.gov (United States)

    Rugo, Hope S; O'Shaughnessy, Joyce A; Perez, Edith A

    2011-11-01

    Approximately 30% of patients with breast cancer will develop metastatic breast disease. Metastatic breast cancer is considered an incurable disease, with complete remission rarely achieved after treatment. The goal of treatment for metastatic breast cancer patients is to increase overall survival time and delay disease progression while ameliorating symptoms and improving or maintaining quality of life. Single-agent therapeutic regimens are appropriate for most metastatic breast cancer patients. Patients with the luminal A subtype of breast cancer, which is more indolent in nature and tends to be more sensitive to treatment in general, often respond well to single-agent therapy. Several chemotherapy regimens are recommended for the treatment of metastatic breast cancer. Compared with single-agent regimens, these combination regimens often produce a greater improvement in the rate of objective response as well as a prolongation of progression-free survival. There is little evidence, however, of improvement in overall survival. Combination chemotherapy regimens are often associated with a greater degree of toxicity depending on schedules and doses used. The use of bevacizumab in metastatic breast cancer is currently a topic of controversy. It is hoped that forthcoming trial data will enable the identification of a group of patients, based on tumor biology, who could benefit from bevacizumab-based therapy.

  7. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    Science.gov (United States)

    Szer, Jeff; Hill, Anita; Weitz, Ilene Ceil

    2012-11-01

    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disorder characterized by chronic intravascular hemolysis as the primary clinical manifestation and morbidities that include anemia, thrombosis, renal impairment, pulmonary hypertension, and bone marrow failure. The prevalence of the PNH clone (from <1-100% PNH granulocytes) is approximately 16 per million, and careful monitoring is required. The average age of onset of the clinical disease is the early 30s, although it can present at all ages. PNH is caused by the acquisition of a somatic mutation of the gene phosphatidylinositol glycan anchor (PIG-A) in a multipotent hematopoietic stem cell (HSC), with clonal expansion of the mutated HSC. The mutation causes a deficiency in the synthesis of glycosylphosphatidylinositol (GPI). In cells derived from normal HSCs, the complement regulatory proteins CD55 and CD59 are anchored to the hematopoietic cell membrane surface via GPI, protecting the cells from complement-mediated lysis. However, in patients with PNH, these 2 proteins, along with numerous other GPI-linked proteins, are absent from the cell surface of red cells, granulocytes, monocytes, and platelets, resulting in complement-mediated intravascular hemolysis and other complications. Lysis of red blood cells is the most obvious manifestation, but as other cell lineages are also affected, this complement-mediated attack contributes to additional complications, such as thrombosis. Eculizumab, a humanized monoclonal antibody against the C5 complement protein, is the only effective drug therapy for PNH patients. The antibody prevents cleavage of the C5 protein by C5 convertase, in turn preventing generation of C5b-9 and release of C5a, thereby protecting from hemolysis of cells lacking the CD59 surface protein and other complications associated with complement activation. Drs. Ilene C. Weitz, Anita Hill, and Jeff Szer discuss 3 recent cases of patients with PNH.

  8. Clinical roundtable monograph: unmet needs in the treatment of chronic lymphocytic leukemia: integrating a targeted approach.

    Science.gov (United States)

    O'Brien, Susan M; Furman, Richard R; Byrd, John C; Smith, Ashbel

    2014-01-01

    Chronic lymphocytic leukemia (CLL) is the most frequently diagnosed hematologic malignancy in the United States. Although several features can be useful in the diagnosis of CLL, the most important is the immunophenotype.Two staging systems--the Binet system and the Rai classification--are used to assess risk. After diagnosis, the first major therapeutic decision is when to initiate therapy, as a watchful waiting approach is often appropriate for patients with asymptomatic disease. Once a patient has met the criteria for treatment, the choice of therapy is the next major decision. Younger patients (<65 years) often receive more aggressive treatment that typically consists of cytotoxic chemotherapy. There is a great unmet need concerning treatment of older patients with CLL, who often present with more comorbid conditions that can decrease their ability to tolerate particular regimens. The current standard of care for older patients with CLL is rituximab plus chlorambucil. The concept of targeted agents is currently an area of intense interest in CLL. The Bruton’s tyrosine kinase inhibitor ibrutinib is the targeted agent that is furthest along in clinical development. It is associated with an overall survival rate of 83%. Idelalisib targets the phosphatidyl inositol 3-kinase and is under evaluation in pivotal trials. Targeted agents offer much promise in terms of efficacy, toxicity, and oral availability. They will change the management of patients with CLL.

  9. American college of gastroenterology monograph on the management of irritable bowel syndrome.

    Science.gov (United States)

    Camilleri, Michael

    2015-04-01

    This editorial reviews a recently published guideline on management of irritable bowel syndrome. The guideline illustrates problems arising from the quality of clinical trials used in systematic reviews and the potential impact of the inherent weaknesses of those trials on rating the strength of evidence and the resulting recommendations.

  10. Clinical roundtable monograph: CD30 in lymphoma: its role in biology, diagnostic testing, and targeted therapy.

    Science.gov (United States)

    Sotomayor, Eduardo M; Young, Ken H; Younes, Anas

    2014-04-01

    CD30, a member of the tumor necrosis factor receptor superfamily, is a transmembrane glycoprotein receptor consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. CD30 has emerged as an important molecule in the field of targeted therapy because its expression is generally restricted to specific disease types and states. The major cancers with elevated CD30 expression include Hodgkin lymphoma and anaplastic large T-cell lymphoma, and CD30 expression is considered essential to the differential diagnosis of these malignancies. Most commonly, CD30 expression is detected and performed by immunohistochemical staining of biopsy samples. Alternatively, flow cytometry analysis has also been developed for fresh tissue and cell aspiration specimens, including peripheral blood and bone marrow aspirate. Over the past several years, several therapeutic agents were developed to target CD30, with varying success in clinical trials. A major advance in the targeting of CD30 was seen with the development of the antibody-drug conjugate brentuximab vedotin, which consists of the naked anti-CD30 antibody SGN-30 conjugated to the synthetic antitubulin agent monomethyl auristatin E. In 2011, brentuximab vedotin was approved by the US Food and Drug Administration for use in Hodgkin lymphoma and anaplastic large cell lymphoma based on clinical trial data showing high response rates in these indications. Ongoing trials are examining brentuximab vedotin after autologous stem cell transplantation, as part of chemotherapy combination regimens, and in other CD30-expressing malignancies, including primary mediastinal large B-cell lymphomas, diffuse large B-cell lymphoma, lymphoma positive for Epstein-Barr virus, peripheral T-cell lymphoma not otherwise specified, and cutaneous anaplastic large cell lymphoma.

  11. Automatic SAR/optical cross-matching for GCP monograph generation

    Science.gov (United States)

    Nutricato, Raffaele; Morea, Alberto; Nitti, Davide Oscar; La Mantia, Claudio; Agrimano, Luigi; Samarelli, Sergio; Chiaradia, Maria Teresa

    2016-10-01

    Ground Control Points (GCP), automatically extracted from Synthetic Aperture Radar (SAR) images through 3D stereo analysis, can be effectively exploited for an automatic orthorectification of optical imagery if they can be robustly located in the basic optical images. The present study outlines a SAR/Optical cross-matching procedure that allows a robust alignment of radar and optical images, and consequently to derive automatically the corresponding sub-pixel position of the GCPs in the optical image in input, expressed as fractional pixel/line image coordinates. The cross-matching in performed in two subsequent steps, in order to gradually gather a better precision. The first step is based on the Mutual Information (MI) maximization between optical and SAR chips while the last one uses the Normalized Cross-Correlation as similarity metric. This work outlines the designed algorithmic solution and discusses the results derived over the urban area of Pisa (Italy), where more than ten COSMO-SkyMed Enhanced Spotlight stereo images with different beams and passes are available. The experimental analysis involves different satellite images, in order to evaluate the performances of the algorithm w.r.t. the optical spatial resolution. An assessment of the performances of the algorithm has been carried out, and errors are computed by measuring the distance between the GCP pixel/line position in the optical image, automatically estimated by the tool, and the "true" position of the GCP, visually identified by an expert user in the optical images.

  12. Clinical roundtable monograph: effective management of quality of life in metastatic breast cancer.

    Science.gov (United States)

    Christopher, Twelves; Gradishar, William J; O'Shaughnessy, Joyce A; Bramsen, Betsy; Lurie, Robert H

    2014-02-01

    Quality of life is accepted as an important consideration in the management of patients with metastatic breast cancer, which remains incurable. Recent clinical trials of newer agents, such as eribulin and trastuzumab emtansine, have incorporated quality of life analyses. Quality of life is impacted by multiple patient-related, disease-related, and treatment-related factors. Therapies most beneficial for maintaining or improving quality of life include those that can effectively reduce tumor burden and tumor-related symptoms, but have toxicity profiles that are well tolerated and easily managed. Overall outcomes of patients with metastatic breast cancer improve when therapy is focused not only on the disease itself, but also on the goals of minimizing diseaserelated and treatment-related symptoms. A paradigm shift now reflected in major guidelines is the incorporation of palliative care strategies earlier in the course of metastatic disease management. The selection and sequence of treatments should be made in cooperation with the patient and after consideration of her particular priorities.

  13. Simplifying sun safety: a guide to the new FDA sunscreen monograph.

    Science.gov (United States)

    Bronfenbrener, Roman

    2014-04-01

    Dermatologists are instrumental in educating their patients about safe sun practices. As residents, we should begin to instill this teaching point into our daily patient encounters. The new US Food and Drug Administration sunscreen guidelines, instituted fully in December 2012, help consumers make more educated decisions about sunscreens they purchase but also introduce new classifications and claims with which dermatologists should be intimately familiar. This article aims to concisely summarize the revisions as well as any continued controversies with the guidelines.

  14. Transforming Monograph Collections with a Model of Collections as a Service

    Science.gov (United States)

    Way, Doug

    2017-01-01

    Financial pressures, changes in scholarly communications, the rise of online content, and the ability to easily share materials have provided libraries the opportunity to rethink their collections practices. This article provides an overview of these changes and outlines a framework for viewing collections as a service. It describes how libraries…

  15. Clinical roundtable monograph: New data in emerging treatment options for chemotherapy-induced nausea and vomiting.

    Science.gov (United States)

    Morrow, Gary R; Navari, Rudolph M; Rugo, Hope S

    2014-03-01

    Chemotherapy-induced nausea and vomiting (CINV) has long been one of the most troublesome adverse effects of chemotherapy, leading to significant detriments in quality of life and functioning, increased economic costs, and, in some cases, the discontinuation of effective cancer therapy. The past 2 decades have witnessed a dramatic increase in the number of effective antiemetic agents, with the introduction of the serotonin (5-hydroxytryptamine [5-HT₃]) receptor antagonists (ondansetron, granisetron, and palonosetron), the neurokinin-1 (NK₁) receptor antagonists (aprepitant and fosaprepitant), and the identification of other agents that have demonstrated efficacy against CINV, including corticosteroids. These agents often provide excellent control of emesis. Nausea, however, has proven more intractable, particularly in the days after administration of chemotherapy. Newer antiemetic agents under study may provide additional CINV control, particularly against delayed nausea. New agents undergoing review by the US Food and Drug Administration for the prevention of CINV include the novel NK₁ receptor antagonist rolapitant and a fixed-dose combination consisting of the novel NK₁ receptor antagonist netupitant and palonosetron (NEPA). Adherence to clinical practice guidelines has been shown to significantly improve CINV control. As antiemetic therapy continues to evolve, it will be important for clinicians to stay informed of new developments and changes in guidelines.

  16. Biowaiver monograph for immediate-release solid oral dosage forms: bisoprolol fumarate.

    Science.gov (United States)

    Charoo, Naseem A; Shamsher, Areeg A A; Lian, Lai Y; Abrahamsson, Bertil; Cristofoletti, Rodrigo; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James; Shah, Vinod P; Dressman, Jennifer

    2014-02-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing bisoprolol as the sole active pharmaceutical ingredient (API) are reviewed. Bisoprolol is classified as a Class I API according to the current Biopharmaceutics Classification System (BCS). In addition to the BCS class, its therapeutic index, pharmacokinetic properties, data related to the possibility of excipient interactions, and reported BE/bioavailability problems are taken into consideration. Qualitative compositions of IR tablet dosage forms of bisoprolol with a marketing authorization (MA) in ICH (International Conference on Harmonisation) countries are tabulated. It was inferred that these tablets had been demonstrated to be bioequivalent to the innovator product. No reports of failure to meet BE standards have been made in the open literature. On the basis of all these pieces of evidence, a biowaiver can currently be recommended for bisoprolol fumarate IR dosage forms if (1) the test product contains only excipients that are well known, and used in normal amounts, for example, those tabulated for products with MA in ICH countries and (2) both the test and comparator dosage form are very rapidly dissolving, or, rapidly dissolving with similarity of the dissolution profiles demonstrated at pH 1.2, 4.5, and 6.8. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association.

  17. Clinical roundtable monograph: Emerging treatment options for TKI-resistant chronic myelogenous leukemia.

    Science.gov (United States)

    Cortes, Jorge; Radich, Jerald; Mauro, Michael J

    2012-10-01

    The development of tyrosine kinase inhibitors (TKIs) that inhibit signaling of the constitutive BCR-ABL protein revolutionized the treatment of chronic myelogenous leukemia (CML). These agents have dramatically changed the treatment landscape for CML, shifting the use of allogeneic stem cell transplantation to selected patients in the salvage setting. Four BCR-ABL TKIs are now commercially available for the treatment of CML: the first-generation TKI imatinib, and the second-generation TKIs dasatinib, nilotinib, and bosutinib. Continuous treatment with these agents induces durable responses in a high proportion of patients with chronic-phase CML. Research is focused on identifying which patients can discontinue therapy without a recurrence of disease. For the group of patients with resistance to TKIs, multiple alternative therapies are being evaluated. The third-generation TKI ponatinib is a BCR-ABL inhibitor that has demonstrated significant activity, including in patients with the TKI resistance mutation T315I. The homoharringtonine derivative omacetaxine mepesuccinate, which inhibits protein synthesis, has also demonstrated clinical activity in CML, including in patients with TKI resistance due to T315I and in patients who have TKI resistance despite no evidence of ABL mutations. It is essential that clinicians implement these new agents with care and change therapies only when appropriate in order to preserve as many options as possible for future use if needed.

  18. Citations and Circulation Counts: Data Sources for Monograph Deselection in Research Library Collections

    Science.gov (United States)

    White, Bruce

    2017-01-01

    Studies of data-driven deselection overwhelmingly emphasise the importance of circulation counts and date-of-last-use in the weeding process. When applied to research collections, however, this approach fails to take account of highly influential and significant titles that have not been of interest to large numbers of borrowers but that have been…

  19. Professors as Teacher Trainers. Career and Technology Education Monograph Series No. 1.

    Science.gov (United States)

    Stutsman, Galen

    This report is concerned with the responsibilities of professors for teacher training. The quality of high school and post high school business teaching depends upon attitudes toward and understandings of business and the economic system which have been developed in the business courses on the college level. The paper briefly examines the…

  20. Pedagogical Perspectives on Using Films in Foreign Language Classes. SFC Monograph #4.

    Science.gov (United States)

    Casanave, Christine Pearson, Ed.; Simons, J. David, Ed.

    This collection of articles on use of films in second language instruction, particularly for teaching English as a second language (ESL) in Japanese colleges and universities, includes: "Whole Movies and Engaged Response in the Japanese University ESL Classroom" (David P. Shea); "Films in English Class: Going Beyond a Content…

  1. Contributions towards a monograph of Phoma (Coelomycetes) III — Supplement. Additional species of section Plenodomus

    NARCIS (Netherlands)

    Boerema, G.H.; Gruyter, de J.

    1999-01-01

    This supplement deals with the diagnostic characteristics and literature data of three species of Phoma sect. Plenodomus: Phoma korfii spec. nov. (synanamorph Sclerotium orobanches Schwein.: Fr.), Phoma pimpinellae spec. nov. (teleomorph Leptosphaeria pimpinellae Lowen & Sivan.) and Phoma etheridgei

  2. [Non-febrile syndromes in the traveler returning from tropical regions admitted in a monographic unit].

    Science.gov (United States)

    Anula-Morales, A; Martin-Giner, B; Hernández-Cabrera, M; Carranza-Rodríguez, C; Pisos-Álamo, E; Jaén-Sánchez, N; Pérez-Arellano, J L

    2017-04-01

    The aim was to analyse those syndromes without fever in travellers who return from tropical regions evaluated at our Department of Infectology and Tropical Medicine. Clarifying these conditions intends to reach earlier diagnoses and, perhaps, to avoid the emergence and spread of imported diseases, as well as to establish appropriate preventive measures. An observational descriptive transversal study was performed, selecting those patients who returned from tropical regions without fever (n = 281), amongst all travellers evaluated in our department between 1998 and 2013. We analysed demographic features, information related to the trip, as well as the presenting complaints and the diagnoses. A total of 281 international travellers presenting without fever were analysed. Only 39% had received health counsel prior to travelling. The most visited regions were Lat-in America (38.8%), Africa (37.8%) and Asia (13.6%). 15% of patients were asymptomatic or suffered from non-infectious conditions. Among the rest, most had either gastrointestinal (46%) or cutaneous (34%) syndromes. The main gastrointestinal condition was diarrhoea, with a microbiological diagnosis reached in almost 50% of cases. Regarding cutaneous syndromes, arthropods bites (31%) and different bacterial lesions (20%) were most common. Approximately 10% of patients in Travel Medicine are international travellers returning from tropical regions, half of them with no fever. Most are diagnosed with infectious diseases, mainly gastrointestinal or cutaneous syn-dromes. Eosinophilia is the third problem in frequency among this group of patients, and sexually transmitted infections are rare in our cohort. It is important to emphasize in preventive activities.

  3. Biowaiver monographs for immediate-release solid oral dosage forms: ketoprofen.

    Science.gov (United States)

    Shohin, Igor E; Kulinich, Julia I; Ramenskaya, Galina V; Abrahamsson, Bertil; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Groot, D W; Barends, Dirk M; Dressman, Jennifer B

    2012-10-01

    Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing ketoprofen are reviewed. Ketoprofen's solubility and permeability, its therapeutic use and therapeutic index, pharmacokinetic properties, data related to the possibility of excipient interactions, and reported BE/bioavailability (BA)/dissolution data were taken into consideration. The available data suggest that according to the current Biopharmaceutics Classification System (BCS) and all current guidances, ketoprofen is a weak acid that would be assigned to BCS Class II. The extent of ketoprofen absorption seems not to depend on formulation or excipients, so the risk of bioinequivalence in terms of area under the curve is very low, but the rate of absorption (i.e., BE in terms of peak plasma concentration, C(max) ) can be altered by formulation. Current in vitro dissolution methods may not always reflect differences in terms of C(max) for BCS Class II weak acids; however, such differences in absorption rate are acceptable for ketoprofen with respect to patient risks. As ketoprofen products may be taken before or after meals, the rate of absorption cannot be considered crucial to drug action. Therefore, a biowaiver for IR ketoprofen solid oral dosage form is considered feasible, provided that (a) the test product contains only excipients present also in IR solid oral drug products containing ketoprofen, which are approved in International Conference on Harmonisation or associated countries, for instance, as presented in this paper; (b) both the test drug product and the comparator dissolve 85% in 30 min or less in pH 6.8 buffer; and (c) test product and comparator show dissolution profile similarity in pH 1.2, 4.5, and 6.8. When one or more of these conditions are not fulfilled, BE should be established in vivo.

  4. On Amazonian Ethnography. The Monograph as a Process of Endless Elaboration (Fieldwork among the Yagua, Peru

    Directory of Open Access Journals (Sweden)

    Chaumeil, Jean Pierre

    2008-06-01

    Full Text Available The author attempts to make explicit certain aspects of his fieldwork experience among the Yagua, in the Peruvian Amazon (1971-2008, providing us with details of this experience as a learning process. His recollections take him to reflect on the ethnography as a gender, which he understands not so much as a stable, self-explanatory directive —as it is commonly received— as quite the opposite: as a process of continual elaboration.

    El autor trata de explicitar ciertos aspectos de su experiencia etnográfica entre los Yagua de la Amazonía peruana (1971-2008, deteniéndose en la genealogía de aprendizaje concreto de dicho proceso. Sus recuerdos le permiten reflexionar sobre el género monográfico, que concibe no tanto como una fórmula estática o replegada sobre ella misma —como se la piensa habitualmente— sino todo lo contrario: como un proceso de construcción permanente.

  5. Studies in Annonaceae. II. A monograph of the genus Anaxagorea A. St. Hil. Part 1

    NARCIS (Netherlands)

    Maas, P.J.M.; Westra, L.Y.Th.

    1985-01-01

    Anaxagorea A. St. Hil. is distinct from other Annonaceae by the fruits. Unlike most members of the family, it occurs both in the Neotropics and in the Palaeotropics. Several chapters are devoted to a.o. morphology, anatomy, karyology, palynology, chemistry, pollination and seed dispersal, geography

  6. Studies in Annonaceae. II. A monograph of the genus Anaxagorea A. St. Hil. Part 2

    NARCIS (Netherlands)

    Maas, P.J.M.; Westra, L.Y.Th.

    1985-01-01

    Anaxagorea A. St. Hil. is distinct from other Annonaceae by the fruits. Unlike most members of the family, it occurs both in the Neotropics and in the Palaeotropics. Several chapters are devoted to a.o. morphology, anatomy, karyology, palynology, chemistry, pollination and seed dispersal, geography

  7. The Syntactic Patterns of Telugu and English: A Study in Contrastive Analysis. Monograph No. 5.

    Science.gov (United States)

    Prakasham, V.; Verma, S. K.

    This contrastive analysis of Telugu and English covers the structure of sentences, clauses, and "groups" (phrases) from a pedagogical point of view. Areas of difficulty for Telugu-speaking students of English as a second language are listed, and a list of errors commonly made by these students is appended. (JB)

  8. Review of the monograph Mathematical Treatment and Application of Uncertain In-formation

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@The present age is an informational one. Treating the information has become an important step for people to make quantitative analysis in ordinary life, production, scientific study, etc. People have already obtained rich experience and knowledge about treating certain informa-tion. And this is just called classical mathematics. In order to represent and treat uncertain information (random in-formation, fuzzy information, grey information and unas-certained information), uncertain mathematics has ap-peared correspondingly (probability statistics, fuzzy math ematics, grey mathematics and unascertained mathemat- ics). Probability statistics[1], fuzzy mathematic[2], grey mathematics[3] and unascertained mathematics[4] are used to represent and treat random information, fuzzy informa-tion, grey information and unascertained information, respectively. If information with only one uncertainty is named mono-information, then probability statistics, fuz-zy mathematics, grey mathematics and unascertained mathematics are all used to represent and treat the mono- information.

  9. Global Collective Resources: A Study of Monographic Bibliographic Records in WorldCat.

    Science.gov (United States)

    Perrault, Anna H.

    In 2001, WorldCat, the primary international bibliographic utility, contained 45 million records with over 750 million library location listings. These records span over 4,000 years of recorded knowledge in 377 languages. Under the auspices of an OCLC/ALISE (Online Computer Library Center/Association of Library and Information Science Educators)…

  10. Practical Public Relations: Effective PR Techniques for School Library/Media Specialists. Monograph Series No. 5.

    Science.gov (United States)

    Behm, Mary W., Ed.

    This handbook of publicity ideas suggests activities and themes to highlight services and resources of school media centers, including approaches to students, faculty, administration, and the community at large. A 14-item annotated bibliography and six mailing list addresses are provided as additional sources for ideas. Clip art illustrations…

  11. A systematic monograph of the Recent Pentastomida, with a compilation of their hosts

    NARCIS (Netherlands)

    Christoffersen, M.L.; De Assis, J.E.

    2013-01-01

    We compile all published information on the Recent Pentastomida published to date, including complete synonyms, and species distributions. All host species are cited and their names updated. A taxonomical history of the group, a synthesis of phylogenetic information for the taxon, and a summary of t

  12. Psychosocial Characteristics of Drug-Abusing Women. Services Research Monograph Series.

    Science.gov (United States)

    Burt, Marvin R.; And Others

    In recent years considerable attention has been paid to the status of women as drug abusers and as clients in drug treatment programs. A study of drug abusers' characteristics found a significantly higher history of non-medical psychotherapeutic drug use for females than for males; however, males had a higher prevalence of illicit drug use.…

  13. Personality Characteristics and Learning Style Preferences of Adult Basic Education Students. Research Monograph.

    Science.gov (United States)

    Manzo, Anthony V.; And Others

    The study described in the report identifies personality characteristics and learning styles of adult basic education (ABE) students on the basis of three instruments: the Luscher Color Test, the Manzo Bestiary Inventory, and the Learning Preference Inventory. The volunteer sample consisted of 83 ABE students. Subsample comparison groups consisted…

  14. Changing Patterns of Finance in Higher Education. Country Study: United States of America. OECD Educational Monographs.

    Science.gov (United States)

    Organisation for Economic Cooperation and Development, Paris (France).

    This report on the United States of America is one in a series of country studies prepared in the framework of the Organization for Economic Cooperation and Development (OECD) Education Committee activity on changing patterns of finance in higher education. The United States maintains the largest and most diverse system of higher education in the…

  15. ASIS Thesaurus of Information Science and Librarianship. ASIS Monograph Series. Second Edition.

    Science.gov (United States)

    Milstead, Jessica L., Ed.

    This thesaurus covers the fields of information science and librarianship to a depth that will adequately support indexing, with coverage of related and peripheral fields as warranted by the strength of their relationship to information science and librarianship. Among the related fields are computer science, linguistics, and behavioral and…

  16. Adolescent Marijuana Abusers and Their Families. Research Monograph Series, No. 40.

    Science.gov (United States)

    Hendin, Herbert; And Others

    Substantial evidence is accumulating which emphasizes the significant role of the family for drug abusing adolescents. To investigate the influence of the family on adolescents (N=17) involved in heavy marihuana use, interviews with family members, case studies of each adolescent, and psychological evaluations were conducted to determine the…

  17. Qatar's School Transportation System: Supporting Safety, Efficiency, and Service Quality. Monograph

    Science.gov (United States)

    Henry, Keith; Younossi, Obaid; Al-Dafa, Maryah; Culbertson, Shelly; Mattock, Michael G.; Light, Thomas; Rohr, Charlene

    2012-01-01

    In consideration of the many challenges associated with Qatar's continued growth and demographic changes, the government of Qatar is interested in updating its school transportation system (STS). This volume assesses the perspectives of parents and school administrators on Qatar's STS, identifies a vision and goals for the STS, reviews…

  18. A Year as an Educator in Northwest China. World Education Monograph Series, Number Two.

    Science.gov (United States)

    Elias, Richard F.

    Chinese children must attend school until age 16, and education consists of elementary schools for ages 6-13 and lower middle schools for ages 13-16. While the economic planning of the national government in Beijing (China) dictates what will be emphasized, the school curriculum includes instruction in ideology, Chinese language, calligraphy, fine…

  19. Roots of Resistance: Land Tenure in New Mexico, 1680-1980. Monograph Number 10.

    Science.gov (United States)

    Ortiz, Roxanne Dunbar

    Focusing on land tenure patterns from 1860 to 1980, this study is a chronological socioeconomic interpretation of the history of northern New Mexico. Chapter One describes the development of the Pueblo Indian land use system prior to colonization. Chapter Two deals with the first colonial period (1598-1693) of land tenure in northern New Mexico.…

  20. Notice on the Issuance of Monograph "China Motorcycles-Marching into the Outside World"

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ "China's Foreign Trade", which has been issuing globally for more than 40 years, is an authoritative magazine introducing China export commodities, enterprises and relevant information, and is the window for other countries to know about the situation of China export and the major channel to access China export information.

  1. Anaerobic Digestion. Selected Instructional Activities and References. Instructional Resources Monograph Series.

    Science.gov (United States)

    Townsend, Robert D., Comp.

    Focusing specifically on the wastewater treatment process of anaerobic digestion, this document identifies instructional and reference materials for use by professionals in the field in the development and implementation of new programs or in the updating of existing programs. It is designed to help trainers, plant operators, educators, engineers,…

  2. Modes of Access: The Influence of Dissemination Channels on the Use of Open Access Monographs

    Science.gov (United States)

    Snijder, Ronald

    2014-01-01

    Introduction: This paper studies the effects of several dissemination channels in an open access environment by analysing the download data of the OAPEN Library. Method: Download data were obtained containing the number of downloads and the name of the Internet provider. Based on public information, each Internet provider was categorised. The…

  3. Glosario de Tecnologia Educativa. Monografia No. 1 (Glossary of Educational Technology. Monograph No. 1).

    Science.gov (United States)

    Chadwick, Clifton; Rojas, Alicia Mabel

    This glossary offers definitions of almost 600 terms normally associated with the field of educational technology in brief and easy-to-understand form, all in Spanish (a Portugese version exists). The terms are organized into six major areas: learning, communications, instructional design, evaluation, media production, and systems theory. (Author)

  4. AMTA Monograph Series - Effective Clinical Practice in Music Therapy Early Childhood and School Age Educational Settings

    Science.gov (United States)

    Humpal, Marcia Earl, Ed.; Colwell, Cynthia, Ed.

    2006-01-01

    Educators, families, and media in increasing numbers are recognizing the unique role music plays in young children's development. More and more daycare, preschool, and early intervention centers offer employment opportunities that reflect the needs and attitudes of our ever-changing society. Furthermore, Federal and state regulations, a changing…

  5. Financing Basic Education in Bangladesh. CREATE Pathways to Access. Research Monograph No. 12

    Science.gov (United States)

    Al-Samarrai, Samer

    2007-01-01

    This paper presents education finance trends for Bangladesh since 2000. It shows that while government spending on education as a proportion of national income has stagnated, it has increased in real terms. Real increases in education spending have resulted in substantial increases in per student spending in basic education. At primary, enrolment…

  6. Transforming Teaching and Learning in Urban Schools through Alternative Assessment. Urban Monograph Series.

    Science.gov (United States)

    Winking, Deborah L.; Bond, Linda Ann

    This paper looks at alternative assessment and explores its place in educational reform. It gives a snapshot of alternative assessment in practice, guidelines for establishing it as part of the urban school culture, and resources for additional information. Alternative assessments differ from traditional tests in that they require students to…

  7. A taxonomic monograph of the genus Tylodinus Champion (Coleoptera: Curculionidae: Cryptorhynchinae: Tylodina) of Chiapas, Mexico.

    Science.gov (United States)

    Luna-Cozar, Jesús; Anderson, Robert S; Jones, Robert W; León-Corté, Jorge L

    2014-04-15

    The species of the genus Tylodinus from the Mexican state of Chiapas are revised. We examined 989 specimens representing 36 species; 23 species are grouped into eight species groups with 13 species considered as Incertae sedis. A total of 32 species are described as new and one species is a new record for México. Species groups  (numbers of species in parentheses) and species are: Tylodinus buchanani species group (6) T. buchanani new species (type locality: Chiapas, Unión Juárez, Volcán Tacan), T. exiguus new species (type locality: Chiapas, Motozintla, 7 km SSW Motozintla de Mendoza), T. ixchel new species (type locality: Chiapas, Unión Juarez, Volcán Tacan), T. jonesi new species (type locality: Chiapas, Angel Albino Corzo, Reserva de la Biosfera el Triunfo, Campamento el Quetzal), T. variabilis new species (type locality: Chiapas, San Cristóbal de las Casas, Cerro Huitepec), T. wibmeri new species (type locality: Chiapas, Motozintla, 7 km SSW Motozintla de Mendoza); Tylodinus canaliculatus species group (3) T. canaliculatus Champion (Chiapas, Unión Juárez, Volcán Tacan, new record for  México), T. sepulturaensis new species (Type locality: Chiapas, Villa Corzo, Ejido Sierra Morena), T. triumforium new species (Type locality: Chiapas, La Concordia, 4 km SE Custepec); Tylodinus cavicrus species group (3) T. cavicrus Champion, T. pseudocavicrus new species (type locality: Chiapas, San Cristóbal de las Casas, Cerro Huitepec), T. rugosus new species (type locality: Chiapas, Villa Flores, Sierra Morena); Tylodinus coapillensis species group (2) T. coapillensis new species (type locality: Chiapas, Coapilla, ca. 10.5 km NE Coapilla), T. leoncortesi new species (type locality: Chiapas, Pueblo Nuevo Solistahuacán, La Yerbabuena); Tylodinus mutabilis species group (2) Tylodinus mutabilis new species (type locality: Chiapas, Villa Corzo, Ejido Sierra Morena), T. parvus new species (type locality: Chiapas, Trinitaria, Lagunas de Montebello); Tylodinus nodulosus species group (3) T. andersoni new species (Chiapas, Ángel Albino Corzo, Reserva El Triunfo, Polígono 1), T. nodulosus (Boheman), T. zilchi Kuschel; Tylodinus pusillus species group (2) T. porvenirensis new species (type locality: Chiapas, El Porvenir, El Porvenir (2 km NE)), T. pusillus new species (type locality: Chiapas, 4 km SE Custepec); Tylodinus spiniventris species group (2) T. lum new species (Chiapas, San Cristóbal de las Casas, Cerro Huitepec), and T. spiniventris new species (type locality: Chiapas, San Cristóbal de las Casas, Reserva Huitepec); Incertae sedis (13) T. pinguis new species (type locality: Chiapas, Ángel Albino Corzo, Reserva El Triunfo, Polígono 1) , T. kissingeri new species (type locality: Chiapas, Tapalapa, ca. 14 km NE Coapilla), T. complicatus new species (type locality: Chiapas, Pueblo Nuevo Solistahuacán, La Yerbabuena), T. dominicus new species (type locality: Chiapas, Villa Corzo, Reserva de la Biósfera La Sepultura), T. noctis new species (type locality: Chiapas, Coapilla, ca. 10.5 km NE Coapilla), T. rufus new species (type locality: Chiapas, San Cristóbal de las Casas, Cerro Huitepec); T. branstetteri new species (type locality: Chiapas, La Concordia, 4 km SE Custepec), T. kuscheli new species (type locality: Chiapas, Villa Flores, Ejido Sierra Morena), T. pappi new species (type locality: Chiapas, Unión Juárez, Volcán Tacan), T. gibbosus new species (type locality: Chiapas, Pueblo Nuevo Solistahuacán, Yerbabuena Reserve), T. immundus new species (type locality: Chiapas, San Cristóbal de las Casas Cerro Huitepec), T. intzin new species (type locality: Chiapas, Tenejapa, Yashanal), T. elongatus new species (type locality: Chiapas, Ángel Albino Corzo, Reserva El Triunfo, Polígono 1). Three species (T. nodulosus (Boheman), T. zilchi Kuschel and T. cavicrus Champion) are not known to occur in Chiapas but were included in this study to be more representative of inter- and intraspecific variation and to provide a better definition of the taxonomic limits of species and species groups.        Species groups are characterized and taxonomic composition and general distribution and ecological correlates summarized. Diagnoses and distributions are given for all species and ecological information is presented where available. Immature stages, life history and food habits are not known for any of the species. 

  8. State and local solar energy policy: meeting low-income needs. [Monograph

    Energy Technology Data Exchange (ETDEWEB)

    Okagaki, A.

    1981-01-01

    This report examines state and local solar-financing programs from the perspective of the low-income consumer. It analyzes 10 specific state and local programs, including consumer loans, technology grants, tax incentives, and financing for small businesses and cooperatives. The report also assesses the methods by which solar manufacture, purchase, and installation can be enhanced through direct public subsidies. The report concludes that only a few of the existing low-income financing programs have shown any sensitivity to the needs of low-income consumers. Part of the problem is the general economic climate, high interest rates, and tight money policies, as well as the basic conservatism of financial institutions. Remedies for low-income groups include lower installation costs, access to adequate financing, non-discriminatory programs, inclusion of the rental housing market, educational programs, and the location of solar businesses in depresed areas. 12 references.

  9. My Maverick Bar: A Search for Identity and the “Real Work” of Librarianship

    Directory of Open Access Journals (Sweden)

    Kim Leeder

    2010-06-01

    Full Text Available Summer Interlude Three years, twenty committees, twelve hundred instruction sessions, forty thousand monograph purchases, and half a million reference questions later, I’m at the point in this librarian job where I have enough experience to know how to get things done, and also enough to wonder, “What exactly am I doing?” The more you know, [...

  10. Training of Masters in Philology in Ukraine and Abroad: Search for Educational Strategies

    Directory of Open Access Journals (Sweden)

    Semenog Olena

    2015-03-01

    Full Text Available The paper outlines the modernization experience of philology Master programs in Ukraine, the USA, Poland and Russia. It has been proved that the Masters’ training is on the search educational strategies phase, which allows to form a single educational space on the principles of internationalization, institutionalization, integration, cultural convergence, common goals and values. An important field of Masters’ training is a competency-based approach. It is based on the idea of flexibility, variability of programs, and profiling, philological integration with other humanities, criteria, standards and principles of improving the quality of education. Attention is focused on the formation of constructive-technological, operational, educational, reflective, educational, qualimetric and creative skills of future teachers. Among the perspective forms of education lecture is distinguished as it is focused on the co-creation and co-thinking of lecturer and students, monographic lectures. Among innovative teaching methods and assessment of Master training are selected case-method, cluster, reference compendium, portfolio, performance tests. The variability of final work is defined as an effective way of learning individualization. It has been proved that the result of Master’s training should be the specialist with a high level of social maturity, active citizenship, education, culture and responsibility for his professional and scientific activity.

  11. BOOK REVIEW: Structures in the Universe by Exact Methods: Formation, Evolutions, Interactions (Cambridge Monographs on Mathematical Physics) Structures in the Universe by Exact Methods: Formation, Evolutions, Interactions (Cambridge Monographs on Mathematical Physics)

    Science.gov (United States)

    Coley, Alan

    2010-05-01

    In this book the use of inhomogeneous models in cosmology, both in modelling structure formation and interpreting cosmological observations, is discussed. The authors concentrate on exact solutions, and particularly the Lemaitre-Tolman (LT) and Szekeres models (the important topic of averaging is not discussed). The book serves to demonstrate that inhomogeneous metrics can generate realistic models of cosmic structure formation and nonlinear evolution and shows that general relativity has a lot more to offer to cosmology than just the standard spatially homogeneous FLRW model. I would recommend this book to people working in theoretical cosmology. In the introduction (and in the concluding chapter and throughout the book) a reasonable discussion of the potential problems with the standard FLRW cosmology is presented, and a list of examples illustrating the limitations of standard FLRW cosmology are discussed (including potential problems with perturbation methods). In particular, the authors argue that the assumptions of isotropy and spatial homogeneity (and consequently the Copernican principle) must be properly challenged and revisited. Indeed, it is possible for `good old general relativity' to be used to explain cosmological observations without introducing speculative elements. In part I of the book the necessary background is presented (readers need a background in general relativity theory at an advanced undergraduate or graduate level). There is a good (and easy to read) review of the exact spherically symmetric dust Lemaitre-Tolman model (LT) (often denoted the LTB model) and the Lemaitre and Szekeres models. Light propogation (i.e. null geodesics, for both central and off-center observers) in exact inhomogeneous (LT) models is reviewed. In part II a number of applications of exact inhomogeneous models are presented (taken mainly from the authors' own work). In chapter 4, the evolution of exact inhomogeneous models (primarily the LT model, but also the Szekeres model) is studied regarding structure formation. I thought that the authors describe the advantages and drawbacks of the idealized exact solutions used in the physical modelling in a reasonable manner (although more concise conclusions might have been useful). The authors also address the formation of a galaxy with a central black hole, the formation and evolution of rich galactic clusters and voids and other structures, and the effects of radiation in the models. The most interesting application is presented in chapter 5; namely, the effects of inhomogeneities on observations such as the luminosity distance relation and the explanation of the observed dimming of distant SN Ia (which is usually interpreted within the standard FLRW model in terms of the existence of dark energy). The main conclusion of this work is that data can be reproduced within the LT model (via inhomogeneities in general relativity, but without introducing dark energy). In particular, a number of exact LT solutions were surveyed, and a full discussion of various models in the literature (and a critique of the various assumptions) is presented. In the next chapter the possible resolution of the horizon problem without inflation, in terms of shell crossing in a LT model, is discussed. This is perhaps the most controversial chapter of the book. In the final chapter 7, the influence of inhomogeneous structures in the path of a light ray (for both center and off-center observers in a special Szekeres Swiss cheese model) on the observed temperature distribution of the CMB is discussed. This is a very important topic, but only a heuristic and qualitative study is presented here; more work on the multipole moments of higher order would be necessary for a more comprehensive analysis.

  12. A critical revision of the Genus Aristida being a preliminary study and an introduction to the monograph

    NARCIS (Netherlands)

    Henrard, J.Th.

    1928-01-01

    Habitat frequens in collinis arenosis siccissimis Distr. Mossamedes, ex Giraûl usque ad Cabo negro, inprimis locis sabulosis oceano proximis, v. gr. ad „Praia da Amelia”, denso agmine crescens, per totum fere annum florens et fructificans (Junio, Julio et Septb. 1859 legi). Exsic. Welw. Iter Angol.

  13. Access to and Exclusion from Primary Education in Slums of Dhaka, Bangladesh. CREATE Pathways to Access. Research Monograph No. 45

    Science.gov (United States)

    Cameron, Stuart

    2010-01-01

    Bangladesh's urban population is rising fast. In the capital, Dhaka, some 4 million people live in slums. They are lacking in wealth, power and social connections; probably under-counted in national surveys; and under-served by both government and non-government organisations, many of whom still see poverty as a rural issue or see the urban poor…

  14. Contributions towards a monograph of Phoma (Coelomycetes) — VII. Section Sclerophomella: Taxa with thick-walled pseudoparenchymatous pycnidia

    NARCIS (Netherlands)

    Boerema, G.H.; Gruyter, de J.

    1998-01-01

    This paper deals with ten species of Phoma, characterized by thick-walled pseudoparenchymatous pycnidia. They superficially resemble the thick-walled pycnidial phenotype in species of Phoma sect. Plenodomus, but scleroplectenchyma is lacking and teleomorphs belong to Didymella, not Leptosphaeria. Ke

  15. Holistic Integrative Analysis of International Change: A Commentary on Teaching Emergent Futures (Proteus Monograph Series. Volume 1, Issue 3)

    Science.gov (United States)

    2008-01-01

    Mayan insurgency, often related to recurrent globalization- style regional development agendas, throughout their history; but in the former, a modern...system as having occurred when “all the civil structures simply turn their backs on the aggressors” (Havel 1991, 109), a subtle syndromes shift that

  16. Fosterage and Access to Schooling in Savelugu-Nanton, Ghana. CREATE Pathways to Access. Research Monograph No. 59

    Science.gov (United States)

    Rolleston, Caine

    2011-01-01

    Fosterage is an important cultural institution which serves to strengthen kinship solidarity among a range of other functions including meeting needs for child labour. Its effects on education are ambiguous. This study examines fostering as a possible contributor to the low levels of educational access and progress in the district using secondary…

  17. Seasonality and Access to Education: The Case of Primary Education in Sub-Saharan Africa. Research Monograph No. 31

    Science.gov (United States)

    Hadley, Sierd

    2010-01-01

    This paper draws together research on seasonality, child labour and education in the context of primary education in sub-Saharan Africa. It describes how income poverty and demand for labour can fluctuate within and between years, affecting participation and progression through school systems. It highlights how analysis of the private and public…

  18. School Dropouts or Pushouts? Overcoming Barriers for the Right to Education. CREATE Pathways to Access. Research Monograph No. 40

    Science.gov (United States)

    Reddy, Anugula N.; Sinha, Shantha

    2010-01-01

    Persistently high dropout rates are one of the biggest challenges to fulfilling the right to education in India. This paper attempts to assess the magnitude of the problem of dropout. The paper critically reviews the evidence on some of the commonly cited reasons for dropout, including poverty, limited to access to credit, child labour, and…

  19. The Practice of Conservation of Library Materials in Sub-Saharan Africa. Monograph on Africana Librarianship No. 3.

    Science.gov (United States)

    Ojo-Igbinoba, M. E.

    This document is concerned with the practice of conservation of library materials in African university libraries south of the Sahara and north of the Limpopo. Data were collected using a questionnaire mailed to 42 university libraries in Sub-Saharan Africa. Responses were received from 27 libraries for a 64% response rate. Data analysis was…

  20. Data-driven deselection for monographs: a rules-based approach to weeding, storage, and shared print decisions

    Directory of Open Access Journals (Sweden)

    Rick Lugg

    2012-07-01

    Full Text Available The value of local print book collections is changing. Even as stacks fill and library traffic grows, circulation continues to decline. Across the ‘collective collection’, millions of unused books occupy prime central campus space. Meanwhile, users want more collaborative study space and online resources. Libraries want room for information commons, teaching and learning centers and cafes. Done properly, removing unused books can free space for these and other purposes, with little impact on users. Many low-use titles are securely archived, accessible digitally, and widely held in print. Surplus copies can be removed without endangering the scholarly record. But identifying candidates for deselection is time-consuming. Batch-oriented tools that incorporate both archival and service values are needed. This article describes the characteristics of a decision-support system that assembles deselection metadata and enables library-defined rules to generate lists of titles eligible for withdrawal, storage, or inclusion in shared print programs.

  1. Data-driven deselection for monographs: a rules-based approach to weeding, storage, and shared print decisions

    OpenAIRE

    Rick Lugg

    2012-01-01

    The value of local print book collections is changing. Even as stacks fill and library traffic grows, circulation continues to decline. Across the ‘collective collection’, millions of unused books occupy prime central campus space. Meanwhile, users want more collaborative study space and online resources. Libraries want room for information commons, teaching and learning centers and cafes. Done properly, removing unused books can free space for these and other purposes, with little impact on ...

  2. Maternity Leave in Australia: Employee and Employer Experiences. Report of a Survey. Australian Institute of Family Studies Monograph No. 7.

    Science.gov (United States)

    Glezer, Helen

    A study was made to obtain a broad overview of the operation of maternity leave in Australia from the perspectives of employees and employers. The study included: (1) an employee survey exploring the use and non-use of maternity leave and identifying determinants of taking maternity leave and of retaining women in the labor force after childbirth;…

  3. Monograph "IV Internet, Law and Politics Congress. Social Software and Web 2.0: Legal and Political Implications"

    Directory of Open Access Journals (Sweden)

    Albert Padró-Solanet

    2008-09-01

    Full Text Available

    L'impacte del Web 2.0 en els camps del dret i de la política ha estat el fil conductor que ha lligat sessions i ponències del IV Congrés d'IDP celebrat el passat mes de juny a la seu de la Universitat Oberta de Catalunya. La denominació Web 2.0 és una forma críptica d'indicar que Internet, en els darrers anys, ha sofert un canvi revolucionari. Les diferents versions del programari s'ordenen amb un número que només canvia quan es refà el programa, mentre que les millores parcials s'indiquen amb un número posterior a un punt decimal. Web 2.0 destaca que Internet ha fet un salt qualitatiu respecte a la Internet primitiva, el Web 1.0. Aquest canvi prové, no només de l'increment de la difusió de l'ús d'un nou mitjà de comunicació, Internet (aquest seria encara un canvi merament quantitatiu; sinó del desenvolupament d'aplicacions (blogs, wikis, Flickr, YouTube, Facebook, MySpace... que han abaratit els costos d'utilitzar la Xarxa de forma interactiva i creativa, han generat comunitats col·laboratives, i han permès que tant la producció com la difusió de continguts es trobin efectivament descentralitzats. Aquesta transformació està començant a afectar radicalment els entorns dels sistemes socials, econòmics i polítics.

  4. Monograph of the Afrotropical species of Scelio Latreille (Hymenoptera, Platygastridae), egg parasitoids of acridid grasshoppers (Orthoptera, Acrididae)

    Science.gov (United States)

    Yoder, Matthew J.; Valerio, Alejandro A.; Polaszek, Andrew; van Noort, Simon; Masner, Lubomír; Johnson, Norman F.

    2014-01-01

    Abstract The genus Scelio is a cosmopolitan and speciose group of solitary parasitoids of the eggs of short-horned grasshoppers (Orthoptera: Acrididae). A number of these hosts are important pests, including plague locusts of the genus Schistocerca. Species of Scelio are recognized as potentially important biological control agents, but this possibility has yet to be fully realized, in part because the species-level taxonomy is still incompletely developed. The species of the pulchripennis group have been recently revised. As a continuation of this effort, here we revise the Afrotropical species of Scelio, excluding the pulchripennis species group. Sixty two (62) species are treated, 48 of which are new. Species are classified into the following species groups: ernstii (12 species, 9 new), howardi (23 species, 19 new), ipomeae (6 species, 5 new), irwini (4 species, 3 new), simoni (3 new species) and walkeri (12 species, 9 new). Keys to species groups and to the species within each group are provided. New species described are: S. albatus Yoder, sp. n., S. aphares Yoder, sp. n., S. apospastos Yoder, sp. n., S. ardelio Yoder, sp. n., S. aurantium Yoder, sp. n., S. balo Valerio & Yoder, sp. n., S. bayanga Yoder, sp. n., S. bubulo Yoder, sp. n., S. cano Yoder, sp. n., S. clypeatus Yoder, sp. n., S. concavus Yoder, sp. n., S. copelandi Yoder, sp. n., S. crepo Yoder, sp. n., S. destico Yoder, sp. n., S. dupondi Yoder, sp. n., S. effervesco Yoder, sp. n., S. erugatus Yoder, sp. n., S. exophthalmus Yoder, sp. n., S. fremo Valerio & Yoder, sp. n., S. gemo Yoder, sp. n., S. grunnio Yoder, sp. n., S. harinhalai Yoder, sp. n., S. igland Yoder, sp. n., S. impostor Yoder, sp. n., S. irwini Yoder, sp. n., S. janseni Yoder, sp. n., S. latro Yoder, sp. n., S. memorabilis Yoder, sp. n., S. modulus Yoder, sp. n., S. mutio Yoder, sp. n., S. ntchisii Yoder, sp. n., S. parkeri Yoder, sp. n., S. phaeoprora Yoder, sp. n., S. pilosilatus Yoder, sp. n., S. pipilo Yoder, sp. n., S. quasiclypeatus Yoder, sp. n., S. retifrons Yoder, sp. n., S. ructo Yoder, sp. n., S. scomma Yoder, sp. n., S. simoni Yoder, sp. n., S. simonolus Yoder, sp. n., S. somaliensis Yoder, sp. n., S. susurro Yoder, sp. n., S. tono Yoder, sp. n., S. transtrum Yoder, sp. n., S. tritus Yoder, sp. n., S. ululo Yoder, sp. n., S. vannoorti Valerio & Yoder, sp. n. The following species are redescribed: S. afer Kieffer, S. chapmani Nixon, S. howardi Crawford, S. ipomeae Risbec, stat. n., S. mauritanicus Risbec, S. philippinensis Ashmead, S. remaudierei Ferrière, S. striatus Priesner,S. taylori Nixon, and S. zolotarevskyi Ferrière. The genus Lepidoscelio Kieffer is treated as a junior synonym of Scelio Latreille, syn. n.; its type species, Lepidoscelio fuscipennis Kieffer, 1905 is transferred to Scelio, renamed Scelio obscuripennis Johnson, nom. n. (preoccupied by Scelio fuscipennis Ashmead, 1887), and redescribed. The following additional species are transferred from Lepidoscelio to Scelio: S. cayennensis (Risbec), comb. n., S. insularis Ashmead, rev. comb., S. luteus (Cameron), comb. n., S. thoracicus Ashmead, rev. comb. Lectotypes are designated for S. africanus Risbec, S. ipomeae Risbec, S. mauritanicus Risbec, S. remaudierei Ferrière, S. sudanensis Ferrière, and S. zolotarevskyi Ferrière. Scelio gaudens Nixon is a junior synonym of Scelio striatus Priesner, syn. n.; Scelio africanus Risbec and Scelio clarus Fouts are both junior synonyms of Scelio afer Kieffer, syn. n.; Scelio sudanensis Ferrière and Scelio cheops Nixon are both junior synonyms of Scelio zolotarevskyi Ferrière, syn. n.; Scelio cahirensis Priesner is a junior synonym of Scelio mauritanicus Risbec, syn. n. The name Scelio chapmanni Nixon is an incorrect original spelling, requiring an emendation to S. chapmani. Digital versions of the identification keys are available at http://www.waspweb.org/Platygastroidea/Keys/index.htm PMID:24624012

  5. Intelligence Scotomas in Central and South America (The Proteus Monograph Series, Volume 1, Issue 4, March 2008)

    Science.gov (United States)

    2008-03-01

    was a member of the National Research Council Committee for Assessment of Non-Lethal Weapons Science and Technology . Dr. Alexander entered the U.S...cultures, ranging from technologically advanced, cosmopolitan groups, to “uncontacted people” still living in ever-shrinking forested areas of...Ford, CitiBank , Blockbuster Video, and that ever-popular symbol, McDonalds. A few government buildings have also been bombed, but there are rarely

  6. Village Literacy Programming in Pakistan: A Comparative ABE Study with Guidelines. Monographs on Comparative and Area Studies in Adult Education.

    Science.gov (United States)

    Hesser, Florence E.

    Ten literacy pilot programs developed by the Adult Basic Education Society (ABES) of Pakistan in Gujranwala, Pakistan, between 1963 and 1973 were analyzed and evaluated to evolve a series of adult literacy program development guidelines. The programs were evaluated on the basis of an eleven-category evaluation system developed by Cyril Houle in…

  7. Economics in Asia: Status Reports on Teaching and Research in Nine Countries. RUSHSAP Series on Occasional Monographs and Papers, 14.

    Science.gov (United States)

    United Nations Educational, Scientific and Cultural Organization, Bangkok (Thailand). Principal Regional Office for Asia and the Pacific.

    This book contains reports on the teaching of and research in economics in nine countries: India, Indonesia, Malaysia, Nepal, the Philippines, Republic of Korea, Sri Lanka, Thailand, and Viet Nam. Each report covers the historical development and growth of the discipline in the country; the development of infra-structures for teaching and…

  8. Students in Transition: Research and Practice in Career Development. The First-Year Experience Monograph Series No. 55

    Science.gov (United States)

    Gore, Paul A., Jr., Ed.; Carter, Louisa P., Ed.

    2011-01-01

    Offering a primer on action research methodologies and examples of practice, "Students in Transition: Research and Practice in Career Development" responds to a dual challenge facing career development educators--designing cutting-edge career development interventions and demonstrating their effectiveness. Overviews of quantitative and qualitative…

  9. Furia y Muerte: Los Bandidos Chicanos (Fury and Death: The Chicano Bandits). Monograph No. 4, Aztlan Publications.

    Science.gov (United States)

    Castillo, Pedro, Ed.; Camarillo, Albert, Ed.

    In the latter half of the nineteenth century five Chicano "bandidos" became prominant in Southwestern history. These "social bandits" were viewed by the dominant Anglo culture as outlaws and criminals; their people saw them as heroes and fighters for justice. Anglos had invaded Northern Mexico, disrupted the existing society, and established a…

  10. Employment of the 307th Medical Battalion (Airborne) in Operations Desert Shield and Desert Storm: A Personal Experience Monograph

    Science.gov (United States)

    1992-05-08

    limited in duration and scope, we didn’t deploy our heavier equipment; X-Ray, Dental , canvas tentage, cots, autoclaves, and miscellaneous support...Oxygen/Fluids Requirements MAJ Clark 16. Medical Supply Stockage 1LT Branch 17. Dental Configuration MAJ Madison 18. Personnel Decontamination SSG...APPARATUS GAS W/ 02 1 0 A6Z252 ANESTESIA SET FIELD: IN CHEST. .. A72260 ANTENNA RC-29- A0712b AXLE CABLE REEL: RL-27 1 0 A79381 ANTENNA GROUP, OE-254 2 1

  11. Phylogeny and taxonomic revision of the Planistromellaceae including its coelomycetous anamorphs: contributions towards a monograph of the genus Kellermania

    OpenAIRE

    Minnis, A.M.; Kennedy, A.H.; Grenier, D.B.; Palm, M. E.; Rossman, A.Y.

    2012-01-01

    The core species of the family Planistromellaceae are included in the teleomorphic genera Planistroma and Planistromella and the connected anamorphic, coelomycetous genera Alpakesa, Kellermania, and Piptarthron. These genera have been defined primarily on the basis of ascospore septation or number of conidial appendages. Due to a lack of DNA sequence data, phylogenetic placement of these genera within the Dothideomycetes, evaluation of monophyly, and questions about generic boundaries could n...

  12. Phylogeny and taxonomic revision of the Planistromellaceae including its coelomycetous anamorphs: contributions towards a monograph of the genus Kellermania

    NARCIS (Netherlands)

    Minnis, A.M.; Kennedy, A.H.; Grenier, D.B.; Palm, M.E.; Rossman, A.Y.

    2012-01-01

    The core species of the family Planistromellaceae are included in the teleomorphic genera Planistroma and Planistromella and the connected anamorphic, coelomycetous genera Alpakesa, Kellermania, and Piptarthron. These genera have been defined primarily on the basis of ascospore septation or number

  13. Comparison of IranMARC Manual (for monographs, MARC21 & UNIMARC with 17 identified problems related to IranMARC

    Directory of Open Access Journals (Sweden)

    Mitra pashootanizadeh

    2014-12-01

    Full Text Available Due to UNIMARC is the basis for the IranMARC format, in this paper all 17 problems identified by Kokabi in 1994 about adoption of UNIMARC in Iran, were compared with IranMARC Manual to find the suggested solutions for them. Because of the international role of MARC21 and UNIMARC, these 17 problems were checked out to reveal if these problems are solved in last update of UNIMARC and if there is any solution for them in MARC21. Eventually with these findings, researchers determined that MARC21 has more adaption with special feature of Persian cataloging and bibliographic features.

  14. Developing Strategies for Communications about Disability: Experiences in the U.S., Hong Kong, India and Pakistan. Monograph #47.

    Science.gov (United States)

    Kolucki, Barbara

    The manual describes a variety of media approaches in the United States, Hong Kong, India, and Pakistan to changing attitudes toward the disabled. Four principles of media communications are stressed: (1) children's television is an important vehicle for changing attitudes; (2) it is vital to know the audience; (3) active participation by the…

  15. Cicer L., a monograph of the genus, with special reference to the chickpea (Cicer arietinum L.), its ecology and cultivation

    NARCIS (Netherlands)

    Maesen, van der L.J.G.

    1972-01-01

    1. The history of the chickpea or gram, Cicer arietinum L., has been described from Homer's time and the earliest finds, 5450 B.C. in Hacilar, Turkey, up to the present day. The crop was first domesticated in Asia Minor and was introduced in India either from Central Asia or Asia Minor, the two mai

  16. Information Subsidies and Media Content: A Study of Public Relations Influence on the News. Journalism Monographs Number 100.

    Science.gov (United States)

    Turk, Judy VanSlyke

    A study examined the relationship between one "family" of the media--newspapers--and one group of public relations (PR) practitioners--public information officers (PIO) for state government agencies--to determine the nature and level of influence the agencies have upon the media's agenda. Eight daily and Sunday newspapers published in New Orleans,…

  17. Formal Occupational Training of Adult Workers; Its Extent, Nature, and Use. Manpower/Automation Research Monograph No. 2.

    Science.gov (United States)

    Bedell, Mary; Bowlby, Roger

    Workers between the ages of 22 and 64 who had completed less than 3 years of college accounted for 52.1 million of the 60.8 million adults in the civilian labor force in 1963. A representative sample of this group was surveyed to determine the extent of their education and whether they had participated in any formal occupational training programs…

  18. Location, Location, Location: Implications of Geographic Situation on Australian Student Performance in PISA 2000. ACER Research Monograph Number 58

    Science.gov (United States)

    Creswell, John; Underwood, Catherine

    2004-01-01

    The primary focus of this report is to examine the effect that geographical location may have on the performance of students from schools from all parts of Australia who participated in the Organisation for Economic Co-operation and Development (OECD)/Programme for International Student Assessment (PISA 2000). Approximately 5,477 students from 231…

  19. Secondary Education in India: Development Policies, Programmes and Challenges. CREATE Pathways to Access. Research Monograph No. 63

    Science.gov (United States)

    Biswal, K.

    2011-01-01

    The paper aims to provide an overview of secondary education in India with focus on the development trajectory currently pursued in the sub-sector. The paper reviews current status, development policies, approaches and reform programmes. While discussing the tremendous progress made in enhancing secondary schooling opportunities in India during…

  20. Translating Theory into Practice: Implications of Japanese Management Theory for Student Personnel Administrators. NASPA Monograph Series Volume 3. First Edition.

    Science.gov (United States)

    Deegan, William L.; And Others

    Japanese management theory was studied to identify specific models for consideration by student personnel administrators. The report is organized into three sections: major components of Japanese management theory, potential implications for student personnel administration, and three models, based on components of Japanese management theory, for…

  1. A taxonomic monograph of the assassin bug genus Zelus Fabricius (Hemiptera: Reduviidae): 71 species based on 10,000 specimens.

    Science.gov (United States)

    Zhang, Guanyang; Hart, Elwood R; Weirauch, Christiane

    2016-01-01

    The New World assassin bug genus Zelus Fabricius, 1803 (Insecta: Hemiptera: Heteroptera: Reduviidae: Harpactorinae: Harpactorini) is revised based on more than 10,000 specimens. Seventy-one species are recognized and twenty-four described as new: Zelus aithaleos sp. n., Zelus amblycephalus sp. n., Zelus antiguensis sp. n., Zelus auralanus sp. n., Zelus bahiaensis sp. n., Zelus banksi sp. n., Zelus casii sp. n., Zelus championi sp. n., Zelus cordazulus sp. n., Zelus fuliginatus sp. n., Zelus gilboventris sp. n., Zelus gracilipes sp. n., Zelus grandoculus sp. n., Zelus kartaboides sp. n., Zelus lewisi sp. n., Zelus panamensis sp. n., Zelus paracephalus sp. n., Zelus rosulentus sp. n., Zelus russulumus sp. n., Zelus spatulosus sp. n., Zelus truxali sp. n., Zelus umbraculoides sp. n., Zelus umbraculus sp. n., and Zelus xouthos sp. n. Five species, Zelus araneiformis Haviland, 1931, Zelus gradarius Bergroth, 1905, Zelus modestus (Stål, 1862), Zelus subfasciatus Stål, 1860 and Zelus vittaticeps Stål, 1866, are removed from Zelus and placed incertae sedis within Harpactorini. Nine new synonyms are recognized (senior synonym in parentheses): Zelus atripes Champion, 1898 syn. nov. (=Zelus conjungens [Stål, 1860]), Zelus dispar Fabricius, 1803 syn. nov. (=Zelus pedestris Fabricius, 1803), Zelus formosus Haviland, 1931 syn. nov. (=Zelus laticornis Herrich-Schaeffer, 1853), Zelus obscuridorsis (Stål, 1860) syn. nov. (=Zelus pedestris), Zelus pallidinervus Haviland, 1931 syn. nov. (=Zelus kartabensis Haviland, 1931), Zelus personatus Berg, 1879 syn. nov. (=Zelus versicolor Herrich-Schaeffer, 1848), Zelus trimaculatus Champion, 1898 syn. nov. (=Zelus means Fabricius, 1803), Zelus trimaculicollis (Stål, 1855) syn. nov. (=Zelus means), and Zelus tristis Haviland, 1931 syn. nov. (=Zelus laticornis). Zelus conjungens (Stål, 1860) stat. rev. Is resurrected from junior synonymy with zealous armillatus (Lepeletier & Seville, 1825). Zelus ambulans Stål, 1862 stat. rev. and Zelus cognatus (Costa, 1862) stat. rev. are resurrected from synonymy with Zelus exsanguis Stål, 1862. Iquitozelus Bérenger syn. nov. is synonymized with Zelus and its only species transferred to Zelus, hence resulting in a new combination, Zelus couturieri (Bérenger, 2003) comb. nov. Lectotypes, paralectotypes or neotypes are designated for a number of species. Habitus images, illustrations of male genitalia, distribution maps and measurements are provided for nearly all species. The three previously recognized subgenera of Zelus are found to be based upon superficial characters and these divisions do not reflect natural groupings. Using sets of characters, especially those of the male genitalia, eleven species groups are proposed. It is also hypothesized that Zelus is closely related to three other New World genera: Atopozelus Elkins, Ischnoclopius Stål and an undescribed genus "Hartzelus" [manuscript name]. Zelus is endemic to the New World, occurring naturally in the Caribbean and all but one of the continental countries, with introductions to Pacific islands, Europe and Chile.

  2. Monograph of the Afrotropical species of Scelio Latreille (Hymenoptera, Platygastridae), egg parasitoids of acridid grasshoppers (Orthoptera, Acrididae).

    Science.gov (United States)

    Yoder, Matthew J; Valerio, Alejandro A; Polaszek, Andrew; van Noort, Simon; Masner, Lubomír; Johnson, Norman F

    2014-01-01

    The genus Scelio is a cosmopolitan and speciose group of solitary parasitoids of the eggs of short-horned grasshoppers (Orthoptera: Acrididae). A number of these hosts are important pests, including plague locusts of the genus Schistocerca. Species of Scelio are recognized as potentially important biological control agents, but this possibility has yet to be fully realized, in part because the species-level taxonomy is still incompletely developed. The species of the pulchripennis group have been recently revised. As a continuation of this effort, here we revise the Afrotropical species of Scelio, excluding the pulchripennis species group. Sixty two (62) species are treated, 48 of which are new. Species are classified into the following species groups: ernstii (12 species, 9 new), howardi (23 species, 19 new), ipomeae (6 species, 5 new), irwini (4 species, 3 new), simoni (3 new species) and walkeri (12 species, 9 new). Keys to species groups and to the species within each group are provided. New species described are: S. albatus Yoder, sp. n., S. aphares Yoder, sp. n., S. apospastos Yoder, sp. n., S. ardelio Yoder, sp. n., S. aurantium Yoder, sp. n., S. balo Valerio & Yoder, sp. n., S. bayanga Yoder, sp. n., S. bubulo Yoder, sp. n., S. cano Yoder, sp. n., S. clypeatus Yoder, sp. n., S. concavus Yoder, sp. n., S. copelandi Yoder, sp. n., S. crepo Yoder, sp. n., S. destico Yoder, sp. n., S. dupondi Yoder, sp. n., S. effervesco Yoder, sp. n., S. erugatus Yoder, sp. n., S. exophthalmus Yoder, sp. n., S. fremo Valerio & Yoder, sp. n., S. gemo Yoder, sp. n., S. grunnio Yoder, sp. n., S. harinhalai Yoder, sp. n., S. igland Yoder, sp. n., S. impostor Yoder, sp. n., S. irwini Yoder, sp. n., S. janseni Yoder, sp. n., S. latro Yoder, sp. n., S. memorabilis Yoder, sp. n., S. modulus Yoder, sp. n., S. mutio Yoder, sp. n., S. ntchisii Yoder, sp. n., S. parkeri Yoder, sp. n., S. phaeoprora Yoder, sp. n., S. pilosilatus Yoder, sp. n., S. pipilo Yoder, sp. n., S. quasiclypeatus Yoder, sp. n., S. retifrons Yoder, sp. n., S. ructo Yoder, sp. n., S. scomma Yoder, sp. n., S. simoni Yoder, sp. n., S. simonolus Yoder, sp. n., S. somaliensis Yoder, sp. n., S. susurro Yoder, sp. n., S. tono Yoder, sp. n., S. transtrum Yoder, sp. n., S. tritus Yoder, sp. n., S. ululo Yoder, sp. n., S. vannoorti Valerio & Yoder, sp. n. The following species are redescribed: S. afer Kieffer, S. chapmani Nixon, S. howardi Crawford, S. ipomeae Risbec, stat. n., S. mauritanicus Risbec, S. philippinensis Ashmead, S. remaudierei Ferrière, S. striatus Priesner,S. taylori Nixon, and S. zolotarevskyi Ferrière. The genus Lepidoscelio Kieffer is treated as a junior synonym of Scelio Latreille, syn. n.; its type species, Lepidoscelio fuscipennis Kieffer, 1905 is transferred to Scelio, renamed Scelio obscuripennis Johnson, nom. n. (preoccupied by Scelio fuscipennis Ashmead, 1887), and redescribed. The following additional species are transferred from Lepidoscelio to Scelio: S. cayennensis (Risbec), comb. n., S. insularis Ashmead, rev. comb., S. luteus (Cameron), comb. n., S. thoracicus Ashmead, rev. comb. Lectotypes are designated for S. africanus Risbec, S. ipomeae Risbec, S. mauritanicus Risbec, S. remaudierei Ferrière, S. sudanensis Ferrière, and S. zolotarevskyi Ferrière. Scelio gaudens Nixon is a junior synonym of Scelio striatus Priesner, syn. n.; Scelio africanus Risbec and Scelio clarus Fouts are both junior synonyms of Scelio afer Kieffer, syn. n.; Scelio sudanensis Ferrière and Scelio cheops Nixon are both junior synonyms of Scelio zolotarevskyi Ferrière, syn. n.; Scelio cahirensis Priesner is a junior synonym of Scelio mauritanicus Risbec, syn. n. The name Scelio chapmanni Nixon is an incorrect original spelling, requiring an emendation to S. chapmani. Digital versions of the identification keys are available at http://www.waspweb.org/Platygastroidea/Keys/index.htm.

  3. Phylogeny and taxonomic revision of the Planistromellaceae including its coelomycetous anamorphs: contributions towards a monograph of the genus Kellermania.

    Science.gov (United States)

    Minnis, A M; Kennedy, A H; Grenier, D B; Palm, M E; Rossman, A Y

    2012-12-01

    The core species of the family Planistromellaceae are included in the teleomorphic genera Planistroma and Planistromella and the connected anamorphic, coelomycetous genera Alpakesa, Kellermania, and Piptarthron. These genera have been defined primarily on the basis of ascospore septation or number of conidial appendages. Due to a lack of DNA sequence data, phylogenetic placement of these genera within the Dothideomycetes, evaluation of monophyly, and questions about generic boundaries could not be adequately addressed in the past. Isolates of nearly all of the known species in these genera were studied genetically and morphologically. DNA sequence data were generated for the nSSU, ITS, nLSU, and RPB1 markers and analysed phylogenetically. These results placed the Planistromellaceae, herein recognised as a distinct family, in an unresolved position relative to other genera within the order Botryosphaeriales. Species representing the core genera of the Planistromellaceae formed a clade and evaluation of its topology revealed that previous morphology-based definitions of genera resulted in an artificial classification system. Alpakesa, Kellermania, Piptarthron, Planistroma, and Planistromella are herein recognised as belonging to the single genus Kellermania. The following new combinations are proposed: Kellermania crassispora, K. dasylirionis, K. macrospora, K. plurilocularis, and K. unilocularis. Five new species are described, namely K. con- fusa, K. dasylirionicola, K. micranthae, K. ramaleyae, and K. rostratae. Descriptions of species in vitro and a key to species known from culture are provided.

  4. A monograph of Allantonectria, Nectria, and Pleonectria (Nectriaceae, Hypocreales, Ascomycota) and their pycnidial, sporodochial, and synnematous anamorphs.

    Science.gov (United States)

    Hirooka, Y; Rossman, A Y; Samuels, G J; Lechat, C; Chaverri, P

    2012-03-15

    Although Nectria is the type genus of Nectriaceae (Hypocreales, Sordariomycetes, Pezizomycotina, Ascomycota), the systematics of the teleomorphic and anamorphic state of Nectriasensu Rossman has not been studied in detail. The objectives of this study are to 1) provide a phylogenetic overview to determine if species of Nectria with Gyrostroma, Tubercularia, and Zythiostroma anamorphs form a monophyletic group; 2) define Nectria, segregate genera, and their species using morphologically informative characters of teleomorphic and anamorphic states; and 3) provide descriptions and illustrations of these genera and species. To accomplish these objectives, results of phylogenetic analyses of DNA sequence data from six loci (act, ITS, LSU, rpb1, tef1 and tub), were integrated with morphological characterisations of anamorphs and teleomorphs. Results from the phylogenetic analyses demonstrate that species previously regarded as the genus Nectria having Gyrostroma,Tubercularia, and Zythiostroma anamorphs belong in two major paraphyletic clades. The first major clade regarded as the genus Pleonectria contains 26 species with ascoconidia produced by ascospores in asci, perithecial walls having bright yellow scurf, and immersed or superficial pycnidial anamorphs (Zythiostroma = Gyrostroma). A lineage basal to the Pleonectria clade includes Nectria miltina having very small, aseptate ascospores, and trichoderma-like conidiophores and occurring on monocotyledonous plants. These characteristics are unusual in Pleonectria, thus we recognise the monotypic genus Allantonectria with Allantonectria miltina. The second major clade comprises the genus Nectriasensu stricto including the type species, N. cinnabarina, and 28 additional species. Within the genus Nectria, four subclades exist. One subclade includes species with sporodochial anamorphs and another with synnematous anamorphs. The other two paraphyletic subclades include species that produce abundant stromata in which the large perithecia are immersed, large ascospores, and peculiar anamorphs that form pycnidia or sporodochia either on their natural substrate or in culture. In this study the evolution of species, morphology, and ecology of the three genera, Allantonectria, Nectria, and Pleonectria, are discussed based on the phylogenetic analyses. In addition, descriptions, illustrations, and keys for identification are presented for the 56 species in Allantonectria, Nectria, and Pleonectria. New species:Nectria argentinensis Hirooka, Rossman & P. Chaverri, Nectria berberidicola Hirooka, Lechat, Rossman, & P. Chaverri, Nectria himalayensis Hirooka, Rossman, & P. Chaverri, Nectria magnispora Hirooka, Rossman, & P. Chaverri, Nectria mariae Hirooka, Fournier, Lechat, Rossman, & P. Chaverri, Nectriapyriformis Hirooka, Rossman & P. Chaverri, Pleonectria boothii Hirooka, Rossman & Chaverri, Pleonectria clavatispora Hirooka, Rossman & P. Chaverri, Pleonectria ilicicola Hirooka, Rossman & P. Chaverri, Pleonectria okinawensis Hirooka, Rossman & P. Chaverri, Pleonectria pseudomissouriensis Hirooka, Rossman & P. Chaverri, Pleonectria quercicola Hirooka, Checa, Areual, Rossman & P. Chaverri, Pleonectria strobi Hirooka, Rossman & P. Chaverri. New combinations:Cosmospora proteae (Marinc., M.J. Wingf. & Crous) Hirooka, Rossman & P. Chaverri, Nectricladiellaviticola (Berk. & M.A. Curtis) Hirooka, Rossman & P. Chaverri, Neocosmospora guarapiensis (Speg.) Hirooka, Samuels, Rossman & P. Chaverri, Neocosmospora rehmiana (Kirschstein) Hirooka, Samuels, Rossman & P. Chaverri, Pleonectria aquifolii (Fr.) Hirooka, Rossman & P. Chaverri, Pleonectria aurigera (Berk. & Rav.) Hirooka, Rossman & P. Chaverri, Pleonectria chlorinella (Cooke) Hirooka, Rossman & P. Chaverri, Pleonectria coryli (Fuckel) Hirooka, Rossman & P. Chaverri, Pleonectria cucurbitula (Tode: Fr.) Hirooka, Rossman & P. Chaverri, Pleonectria lonicerae (Seeler) Hirooka, Rossman & P. Chaverri, Pleonectria rosellinii (Carestia) Hirooka, Rossman & P. Chaverri, Pleonectria rubicarpa (Cooke) Hirooka, Rossman & P. Chaverri, Pleonectria sinopica (Fr.: Fr.) Hirooka, Rossman & P. Chaverri, Pleonectria sphaerospora (Ellis & Everh) Hirooka, Rossman & P. Chaverri, Pleonectria virens (Harkn.) Hirooka, Rossman & P. Chaverri, Pleonectria zanthoxyli (Peck) Hirooka, Rossman & P. Chaverri.

  5. Subjective Well-Being In Later Life: 20 years after the Butterworths monograph series on individual and population aging.

    Science.gov (United States)

    Stones, Michael; Kozma, Albert; McNeil, Kevin; Worobetz, Sarah

    2011-09-01

    This article discusses developments in theory and research on happiness two decades after publication of Psychological Well-Being in Later Life (Butterworths, 1991) by Albert Kozma, Michael Stones, and Kevin McNeil. Major empirical advances include new knowledge about contributions to happiness resulting from genetically related effects and personality. Personality traits have stronger relationships with happiness than was apparent 20 years ago and contribute to covariance between happiness and some of its predictors. Evolving emphases in research include the ways in which genetically related effects influence how people shape, and react to, their environment.

  6. The Honors Thesis: A Handbook for Honors Directors, Deans, and Faculty Advisors. National Collegiate Honors Council Monograph Series

    Science.gov (United States)

    Anderson, Mark; Lyons, Karen; Weiner, Norman

    2014-01-01

    This handbook is intended to help all those who design, administer, and implement honors thesis programs--honors directors, deans, staff, faculty, and advisors--evaluate their thesis programs, solve pressing problems, select more effective requirements or procedures, or introduce an entirely new thesis program. The authors' goal is to provide…

  7. Attitude of Employers of Fitting and Machining Apprentices towards Apprentices. [C.A.T. Education Monograph] No. 15.

    Science.gov (United States)

    Richardson, E.; Clayman, Linda

    As a result of studies on fitting and machining apprentices attitudes toward employers, a study was conducted to obtain the attitudes of a sample of employers toward apprenticeship. Three hundred questionnaires were distributed to employers of fitting and machine students studying at a number of Sydney (Australia) Technical Colleges. An…

  8. Cicer L., a monograph of the genus, with special reference to the chickpea (Cicer arietinum L.), its ecology and cultivation

    NARCIS (Netherlands)

    Maesen, van der L.J.G.

    1972-01-01

    1. The history of the chickpea or gram, Cicer arietinum L., has been described from Homer's time and the earliest finds, 5450 B.C. in Hacilar, Turkey, up to the present day. The crop was first domesticated in Asia Minor and was introduced in India

  9. Parenting and the Child's World: Influences on Academic, Intellectual, and Social-Emotional Development. Monographs in Parenting.

    Science.gov (United States)

    Borkowski, John G.; Ramey, Sharon Landesman; Bristol-Power, Marie

    Conceived around the notion that there are multiple sources of influence on children's development, this volume describes when, where, and how parenting matters and the major antecedents and moderators of effective parenting. The chapters of the volume are as follows: (1) "Beyond the Nurture Assumption: Testing Hypotheses about the Child's…

  10. A critical revision of the Genus Aristida being a preliminary study and an introduction to the monograph

    NARCIS (Netherlands)

    Henrard, J.Th.

    1928-01-01

    Habitat frequens in collinis arenosis siccissimis Distr. Mossamedes, ex Giraûl usque ad Cabo negro, inprimis locis sabulosis oceano proximis, v. gr. ad „Praia da Amelia”, denso agmine crescens, per totum fere annum florens et fructificans (Junio, Julio et Septb. 1859 legi). Exsic. Welw. Iter Angol.

  11. On China's First Modem Indexing Monograph%再谈我国第一部现代索引专著

    Institute of Scientific and Technical Information of China (English)

    谢欢

    2013-01-01

    通过对《索引与索引法——书籍杂志报纸》、Indexing:a handbook of instruction以及《引得说》三本著作的比较研究,认为,钱亚新之《索引与索引法——书籍杂志报纸》一书是我国第一部现代索引专著.

  12. Furia y Muerte: Los Bandidos Chicanos (Fury and Death: The Chicano Bandits). Monograph No. 4, Aztlan Publications.

    Science.gov (United States)

    Castillo, Pedro, Ed.; Camarillo, Albert, Ed.

    In the latter half of the nineteenth century five Chicano "bandidos" became prominant in Southwestern history. These "social bandits" were viewed by the dominant Anglo culture as outlaws and criminals; their people saw them as heroes and fighters for justice. Anglos had invaded Northern Mexico, disrupted the existing society,…

  13. Destalking the Wily Tomato: A Case Study in Social Consequences in California Agricultural Research. Research Monograph No. 15.

    Science.gov (United States)

    Friedland, William H.; Barton, Amy

    The end of the bracero program after 1965 brought about a major change in the growing, harvesting, and processing of California tomatoes which dramatically influenced the structure of the harvesting labor force. In order to determine the social consequences of the transition from man to mechanized harvesting procedures, the following areas of…

  14. Clinical roundtable monograph. Treatment of chemotherapy-induced nausea and vomiting: a post-MASCC 2010 discussion.

    Science.gov (United States)

    Kris, Mark G; Urba, Susan G; Schwartzberg, Lee S

    2011-01-01

    Chemotherapy-induced nausea and vomiting (CINV) is one of the most common and troubling side effects of treatment, and the side effect cancer patients tend to fear most. An improved understanding of the pathophysiology underlying CINV, together with a clear definition of the risk for nausea and vomiting associated with specific chemotherapeutic agents, has for allowed the development of specific and effective antiemetic regimens. Anti­emesis is most effective when used prophylactically, a principle shared among CINV management guidelines. Several antiemetic drug classes are available; among the most effective of these are serotonin (5HT₃) receptor antagonists, neurokinin 1 (NK₁) receptor antagonists, and steroids (primarily dexamethasone), although others are commonly used as well. When choosing an appropriate antiemetic regimen, clinicians should consider patient-specific factors such as sex and prior history of CINV, as well as treatment-specific factors such as the emetogenic potential of each chemotherapeutic agent. Using these factors, clinicians can follow the available algorithms included in guidelines from groups such as the National Comprehensive Cancer Network, the American Society of Clinical Oncology, and the Multinational Association for Supportive Care in Cancer. Ongoing and future clinical trials will be pivotal in helping to further delineate the optimal strategies to prevent and manage CINV in cancer patients.

  15. The New Professional: A Resource Guide for New Student Affairs Professionals and Their Supervisors. Monograph Series Volume 10.

    Science.gov (United States)

    Coleman, David D., Ed.; And Others

    This resource guide for new student affairs professionals reflects on the socialization process experienced by new staff members and offers senior student affairs staff members and graduate preparation program faculty insights to assist them in designing programs for preservice students and new full-time staff appointees. "The New Professional"…

  16. In Times of Challenge: Chicanos and Chicanas in American Society. Mexican American Studies Monograph Series No. 6.

    Science.gov (United States)

    Garcia, Juan R., Ed; And Others

    This anthology compiles articles and essays on Chicano and Chicana political concerns in the 1980's, on cultural aspects of the Chicano experience, and on historical issues and events. The papers are: (1) "Chicano Politics after 1984" by Christine Marie Sierra; (2) "Hacia una Teoria para la Liberacion de la Mujer" (analysis of the relationship of…

  17. Approaches to Research on Teacher Education and Technology. Society for Technology and Teacher Education Monograph Series. No. 1.

    Science.gov (United States)

    Waxman, Hersholt C., Ed.; Bright, George W., Ed.

    This document addresses the use of technology to enrich education. Twelve papers discuss research programs and perspectives and methods of research in technology and teacher education. Titles are: "Research Methods and Paradigms in Technology and Teacher Education" (Hersholt C. Waxman and George W. Bright); "Past and Future Stages in Educational…

  18. A taxonomic monograph of the assassin bug genus Zelus Fabricius (Hemiptera: Reduviidae): 71 species based on 10,000 specimens

    Science.gov (United States)

    Hart, Elwood R; Weirauch, Christiane

    2016-01-01

    Abstract The New World assassin bug genus Zelus Fabricius, 1803 (Insecta: Hemiptera: Heteroptera: Reduviidae: Harpactorinae: Harpactorini) is revised based on more than 10,000 specimens. Seventy-one species are recognized and twenty-four described as new: Zelus aithaleos sp. n., Zelus amblycephalus sp. n., Zelus antiguensis sp. n., Zelus auralanus sp. n., Zelus bahiaensis sp. n., Zelus banksi sp. n., Zelus casii sp. n., Zelus championi sp. n., Zelus cordazulus sp. n., Zelus fuliginatus sp. n., Zelus gilboventris sp. n., Zelus gracilipes sp. n., Zelus grandoculus sp. n., Zelus kartaboides sp. n., Zelus lewisi sp. n., Zelus panamensis sp. n., Zelus paracephalus sp. n., Zelus rosulentus sp. n., Zelus russulumus sp. n., Zelus spatulosus sp. n., Zelus truxali sp. n., Zelus umbraculoides sp. n., Zelus umbraculus sp. n., and Zelus xouthos sp. n. Five species, Zelus araneiformis Haviland, 1931, Zelus gradarius Bergroth, 1905, Zelus modestus (Stål, 1862), Zelus subfasciatus Stål, 1860 and Zelus vittaticeps Stål, 1866, are removed from Zelus and placed incertae sedis within Harpactorini. Nine new synonyms are recognized (senior synonym in parentheses): Zelus atripes Champion, 1898 syn. nov. (=Zelus conjungens [Stål, 1860]), Zelus dispar Fabricius, 1803 syn. nov. (=Zelus pedestris Fabricius, 1803), Zelus formosus Haviland, 1931 syn. nov. (=Zelus laticornis Herrich-Schaeffer, 1853), Zelus obscuridorsis (Stål, 1860) syn. nov. (=Zelus pedestris), Zelus pallidinervus Haviland, 1931 syn. nov. (=Zelus kartabensis Haviland, 1931), Zelus personatus Berg, 1879 syn. nov. (=Zelus versicolor Herrich-Schaeffer, 1848), Zelus trimaculatus Champion, 1898 syn. nov. (=Zelus means Fabricius, 1803), Zelus trimaculicollis (Stål, 1855) syn. nov. (=Zelus means), and Zelus tristis Haviland, 1931 syn. nov. (=Zelus laticornis). Zelus conjungens (Stål, 1860) stat. rev. Is resurrected from junior synonymy with zealous armillatus (Lepeletier & Seville, 1825). Zelus ambulans Stål, 1862 stat. rev. and Zelus cognatus (Costa, 1862) stat. rev. are resurrected from synonymy with Zelus exsanguis Stål, 1862. Iquitozelus Bérenger syn. nov. is synonymized with Zelus and its only species transferred to Zelus, hence resulting in a new combination, Zelus couturieri (Bérenger, 2003) comb. nov. Lectotypes, paralectotypes or neotypes are designated for a number of species. Habitus images, illustrations of male genitalia, distribution maps and measurements are provided for nearly all species. The three previously recognized subgenera of Zelus are found to be based upon superficial characters and these divisions do not reflect natural groupings. Using sets of characters, especially those of the male genitalia, eleven species groups are proposed. It is also hypothesized that Zelus is closely related to three other New World genera: Atopozelus Elkins, Ischnoclopius Stål and an undescribed genus "Hartzelus" [manuscript name]. Zelus is endemic to the New World, occurring naturally in the Caribbean and all but one of the continental countries, with introductions to Pacific islands, Europe and Chile. PMID:27651730

  19. Phylogeny and taxonomic revision of the Planistromellaceae including its coelomycetous anamorphs: contributions towards a monograph of the genus Kellermania

    Science.gov (United States)

    A.M. Minnis; A.H. Kennedy; D.B. Grenier; M.E. Palm; A.Y. Rossman

    2012-01-01

    The core species of the family Planistromellaceae are included in the teleomorphic genera Planistroma and Planistromella and the connected anamorphic, coelomycetous genera Alpakesa, Kellermania, and Piptarthron. These genera have been defined primarily on the basis of...

  20. School Drop Out in Bangladesh: New Insights from Longitudinal Evidence. CREATE Pathways to Access. Research Monograph No. 49

    Science.gov (United States)

    Sabates, Ricardo; Hossain, Altaf; Lewin, Keith M.

    2010-01-01

    This report provides new evidence into the factors that predict school drop out for children in Bangladesh. It also examines similarities and differences between children who enter late into primary schooling, those who are permanently excluded and those who drop out. Our results show that the relationship of the child within the household and the…