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Sample records for monograph presents descriptions

  1. Existing and Emerging Technologies in Education: A Descriptive Overview. CREATE Monograph Series.

    Science.gov (United States)

    Bakke, Thomas W.

    Second in a series of six monographs on the use of new technologies in the instruction of learning disabled students, the paper offers a descriptive overview of new technologies. Topics addressed include the following: (1) techniques for sharing computer resources (including aspects of networking, sharing information through databases, and the use…

  2. "Library Trends" Past and Present: A Descriptive Study.

    Science.gov (United States)

    Auld, Lawrence W. S.

    1988-01-01

    This analysis of "Library Trends" from 1952-86 provides an overall description of authorship and subject content, general comparison of early and late volumes, and more detailed descriptions--including citation analysis--of the three pairs of issues bearing identical titles. Tables present data on authorship, subjects, and citations. (1 reference)…

  3. Monographs and Open Access

    Directory of Open Access Journals (Sweden)

    Geoffrey Crossick

    2016-03-01

    Full Text Available This article presents the project that I led for HEFCE on the implications of OA (open access for monographs and other long-form research publications. The likely requirement that books should be OA if submitted to the REF (Research Excellence Framework after next means that OA development must be based on an understanding of the importance of the monograph in the AHSS (arts, humanities and social sciences as well as the challenges involved in making the transition to online OA. The project focused on three issues and each is summarized in turn in the article: What is the place of the monograph and other long-form publications in AHSS disciplines that makes it so important? What is happening to the monograph and is there a crisis as some suggest? What are the issues involved in moving monographs into a digital and OA environment – not just the challenge of effective business models but also many other aspects of sustaining and enhancing the qualities of the monograph? These include third-party rights, technical challenges, licences and the need for international collaboration.

  4. IARC Monographs

    DEFF Research Database (Denmark)

    Pearce, Neil E; Blair, Aaron; Vineis, Paolo

    2015-01-01

    BACKGROUND: Recently the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also the approach used to perform these evaluations. Some critics have claimed that IARC Working Groups...... carcinogens. We have examined here criticisms of the IARC classification process to determine the validity of these concerns. We review the history of IARC evaluations and describe how the IARC evaluations are performed. DISCUSSION: We conclude that these recent criticisms are unconvincing. The procedures....... This does not mean, however, that the current procedures are flawed. CONCLUSIONS: The IARC Monographs have made, and continue to make, major contributions to the scientific underpinning for societal actions to improve the public's health....

  5. On the rise of Bayesian econometrics after Cowles Foundation monographs 10, 14

    NARCIS (Netherlands)

    Baştürk, N.; Çakmaklı, C.; Ceyhan, S.P.; van Dijk, H.K.

    2014-01-01

    This paper starts with a brief description of the introduction of the likelihood approach in econometrics as presented in Cowles Foundation Monographs 10 and 14. A sketch is given of the criticisms on this approach mainly from the first group of Bayesian econometricians. Publication and citation pat

  6. On the rise of Bayesian econometrics after Cowles Foundation Monographs 10, 14

    NARCIS (Netherlands)

    Baştürk, N.; Çakmak, C.; Pinar Ceyhan, S.; van Dijk, H.K.

    2014-01-01

    This paper starts with a brief description of the introduction of the likelihood approach in econometrics as presented in Cowles Foundation Monographs 10 and 14. A sketch is given of the criticisms on this approach mainly from the first group of Bayesian econometricians. Publication and citation pat

  7. A Description of Preservice Teachers' Task Presentation Skills

    Science.gov (United States)

    Hall, Tina J.; Heidorn, Brent; Welch, Mindy

    2011-01-01

    A teacher's ability to present clear and appropriate movement tasks is strongly related to student learning. The purpose of this study was to describe the ability of preservice teachers to demonstrate task presentation skills following an introductory course in the basics of effective instruction. The task presentations of 15 preservice teachers…

  8. Maintenance Technical Manuals: Format Descriptions and Guidelines for Automated Presentation.

    Science.gov (United States)

    1985-12-01

    regardless of the media by which the information i.esented. Even though the baseline presentation system *.si’ma tel for the automated delivery system... media (i.e., CRT presentation was not a consideration). Nevertheless, some guidance can be provided based on the findings of the limited CRT color...INCH SPACING. CONNECTE R LINKAGE SVSTEN TO A CEA N E L SE RANK . TV! BILL. CR:AN, A LLOWS TH SALES TO SE DOE N EDAD COE ANIL " H MP SCvB IS COM POSED

  9. Monograph on prospective developments in oceanology

    Science.gov (United States)

    Monin, A. S.

    1986-01-01

    Excerpts from a chapter of a monograph, Oceanology in the Year 2000, which has been prepared for publication at the USSR Academy of Sciences' Institute of Oceanology, is presented. The author of this chapter is A. S. Morin, corresponding member of the USSR Academy of Sciences and director of the oceanology institute. The monograph is said to be the collective work of a group of specialists. Monin views prospective developments of oceanology and oceanology related research and development, technology and expedition research.

  10. Monograph for using paleoflood data in Water Resources Applications

    Science.gov (United States)

    Swain, R.E.; Jarrett, R.D.

    2004-01-01

    The Environmental and Water Resources Institute (EWRI) Technical Committee on Surface Water Hydrology is sponsoring a Task Committee on Paleoflood Hydrology to prepare a monograph entitled, "Use of Paleoflood and Historical Data in Water Resources Applications." This paper introduces the subject of paleoflood hydrology and discusses the topics, which are expected to be included in the monograph. The procedure for preparing and reviewing the monograph will also be discussed. The paleoflood hydrology monograph will include a discussion of types of hydrologic and paleoflood data, paleostage indicators, flood chronology, modeling methods, interpretation issues, water resources applications and case studies, and research needs. Paleoflood data collection and analysis techniques will be presented, and various applications in water-resources investigations will be provided. An overview of several flood frequency analysis approaches, which consider historical and paleoflood data along with systematic streamflow records, will be presented. The monograph is scheduled for completion and publication in 2001. Copyright ASCE 2004.

  11. Analyzing Workforce Education. Monograph.

    Science.gov (United States)

    Texas Community & Technical Coll. Workforce Education Consortium.

    This monograph examines the issue of task analysis as used in workplace literacy programs, debating the need for it and how to perform it in a rapidly changing environment. Based on experiences of community colleges in Texas, the report analyzes ways that task analysis can be done and how to implement work force education programs more quickly.…

  12. Multiple Primary Cancer Monograph

    Science.gov (United States)

    To identify groups of cancer survivors that are at increased risk for multiple primary cancers, investigators led an effort to provide the first comprehensive population-based analysis of the risk of subsequent cancer in the U.S., resulting in a monograph.

  13. [DESCRIPTION AND PRESENTATION OF THE RESULTS OF ELECTROENCEPHALOGRAM PROCESSING USING AN INFORMATION MODEL].

    Science.gov (United States)

    Myznikov, I L; Nabokov, N L; Rogovanov, D Yu; Khankevich, Yu R

    2016-01-01

    The paper proposes to apply the informational modeling of correlation matrix developed by I.L. Myznikov in early 1990s in neurophysiological investigations, such as electroencephalogram recording and analysis, coherence description of signals from electrodes on the head surface. The authors demonstrate information models built using the data from studies of inert gas inhalation by healthy human subjects. In the opinion of the authors, information models provide an opportunity to describe physiological processes with a high level of generalization. The procedure of presenting the EEG results holds great promise for the broad application.

  14. Descriptive set theory

    CERN Document Server

    Moschovakis, YN

    1987-01-01

    Now available in paperback, this monograph is a self-contained exposition of the main results and methods of descriptive set theory. It develops all the necessary background material from logic and recursion theory, and treats both classical descriptive set theory and the effective theory developed by logicians.

  15. Monograph of Coccinia (Cucurbitaceae).

    Science.gov (United States)

    Holstein, Norbert

    2015-01-01

    This monograph deals with all 95 names described in the Cucurbitaceae genus Coccinia and recognizes 25 species. Taxonomic novelties are Cocciniaadoensisvar.aurantiaca (C.Jeffrey) Holstein, stat. nov., Cocciniasessilifoliavar.variifolia (A.Meeuse) Holstein, stat. nov., and Cocciniaadoensisvar.jeffreyana Holstein, var. nov. For the 25 species 3157 collections were examined, of which 2024 were georeferenced to produce distribution maps. All species are distributed in sub-Saharan Africa with one species, Cocciniagrandis, extending from Senegal in West Africa east to Indonesia and being naturalized on Pacific Islands, in Australia, the Caribbean, and South America. Coccinia species are dioecious creepers or climbers with simple or bifid tendrils that occupy a range of habitats from arid scrubland, woodlands to lowland rainforest and mist forest. The corolla of Coccinia species is sympetalous, usually pale yellow to orange, and 1 to 4.5 cm long. Pollination is by bees foraging for pollen or nectar. After pollination, the developing ovary often exhibits longitudinal mottling, which usually disappears during maturation. All species produce berries with a pericarp in reddish colors (orange-red through to scarlet red), hence the generic name. The globose to cylindrical fruits contain numerous grayish-beige flat to lenticular seeds. Chromosome numbers are 2n = 20, 24, and 22 + XX/XY. Many Coccinia species are used for food, either as roasted tubers, greens as spinach, or the fruits as vegetables. Medicinal value is established in Cocciniagrandis, of which leaves and sap are used against diabetes.

  16. A Description of Del Mod and Its Final Evaluation, Final Report, Volume I.

    Science.gov (United States)

    Purnell, Charlotte H.; Bolig, John R.

    This monograph presents an overview of five Del Mod System final reports, comments by the project director, financial structure of the Del Mod System, and descriptions of Del Mod Projects. The Del Mod System was concerned with changing the science and mathematics education programs in the state of Delaware. Between 1970 and 1976, Del Mod conducted…

  17. A descriptive analysis of patients presenting to psychosexual clinic at a tertiary care center

    Directory of Open Access Journals (Sweden)

    Rohit Verma

    2013-01-01

    Full Text Available Background: Psychosexual problems are very common presentation, be it with psychiatric or physical illness but there are very few studies available on psychosexual disorders especially in the Indian context. Indian society is deeply ingrained in customs and several misconceptions, myths, prejudices, and social taboos are attached to sex which makes it further very difficult to tackle. Objectives: The aim of this current study was to descriptively analyze the nature of sexual disorders in a tertiary care center. Materials and Methods: The current retrospective chart review included 698 consecutive subjects seeking treatment for their psychosexual problems at the Sexual Clinic, Department of Psychiatry, Dr. Ram Manohar Hospital, New Delhi (between 2006 and 2010. Results: This study observed erectile dysfunction (ED (29.5%, Premature ejaculation (PME (24.6%, Dhat syndrome (DS (18.1%, and ED with PME (17.5% as the common sexual dysfunctions leading to treatment seeking. DS was the major complaint among younger and unmarried individuals. We observed more married individuals seeking treatment for sexual disorders. Conclusions: These findings provide important information on a relatively under-researched area.

  18. The Research Use of Astronomical Monographs

    Science.gov (United States)

    Abt, Helmut A.

    2014-04-01

    I explored the use of astronomical monographs used for research. After scanning 135 monographs (excluding conference proceedings and textbooks) listed in 2000-2003 issues of Physics Today and counting citations of them in 2000-2013 in ADS (Astrophysics Data System), I found that 67% of the monographs received fewer than 2 citations per year. The average citation rate for the 135 monographs is statistically the same as for ApJ papers. In contrast, only 41% of the ApJ papers produce fewer than 2 citations per year. ADS also counts the number of times each book or paper is read on-line. The average in 14 years is 181 ± 27 times for the monographs and 633 ± 47 times for ApJ papers. The total numbers of citations in 14 years for the monographs ranged from 0 to 711. I explored reasons for this range and only learned that it did not depend on (1) the numbers of book reviews published or (2) the scientific stature of the authors. I am unable to predict whether a monograph will be successful or not. The decreasing of references to monographs seems to be due to (1) monographs becoming so expensive that individuals and libraries cannot afford many of them, (2) readers seeming to prefer concise reviews, such as online searches and the Annual Reviews, and (3) most of the monographs having not been available free online.

  19. Baby Boom Equals Career Bust. Monographs on Career Education.

    Science.gov (United States)

    Moore, Charles Guy

    Presenting the Baby Boom (1946-1965) as both a potential social problem and opportunity for American leadership, this monograph discusses the following aspects of this population concern: (1) its immediate and long-term impact on career opportunities for those college graduates who make up the baby boom generation; (2) its impact on those whose…

  20. Patient characteristics upon initial presentation to chiropractic teaching clinics: A descriptive study conducted at one university.

    Science.gov (United States)

    Kaeser, Martha A; Hawk, Cheryl; Anderson, Michelle

    2014-10-01

    Objective : The purpose of this study was to compare demographics and chief complaints of the new patient population at our institution's fee-for-service clinics to the patient population of practicing chiropractors in the United States. We also compared the prevalence of obesity and hypertension to reference standards for the adult population. Methods : Patient data were obtained from the electronic health records. All records identified as new patients during October 2013 were included. Variables of interest were clinic site, patient demographics, blood pressure, body mass index (BMI), chief complaint, and ICD-9 codes. Descriptive statistics were computed and compared to reference standards from previous reports. Results : During October 2013, there were 224 new patients that entered the clinics. The average patient was a 31- to 50-year-old white male. Our clinic patients differed from those seen by US chiropractors in the distribution of all demographic variables. For adult patients, 31.4% were overweight, 29% were obese, and 8% stage 1 or 2 hypertension. Conclusion : New patients in the fee-for-service teaching clinics appear to be dissimilar to those of US practicing chiropractors in several important demographics, characteristics, and types of complaints. The new patients had lower levels of overweight, obesity, and hypertension compared to US reference standards.

  1. Descriptive Study of the Presentation of Human Brucellosis in Colombia (2000-2012

    Directory of Open Access Journals (Sweden)

    Patricia Lopez Guarnizo

    2014-07-01

    Full Text Available This research aims to conduct a descriptive study of the occurrence of human brucellosis in Colombia between 2000 and 2012, and, based on previous studies, to determine the prevalence and incidence of the disease, and the limitations for its timely diagnosis and recognition by the Colombian labor system. The research consisted of searching for and analyzing articles on human brucellosis published between 2000 and 2012 in Colombia. It included a phase of information gathering and unstructured interviews with representatives of brucellosis control programs and experienced professionals. We analyzed 17 studies of human brucellosis cases in personnel at risk in slaughterhouses, retailers and vaccinators for animal brucellosis programs: 10 of them reported prevalences between 0.14% and 10.4%, and seven evidenced seropositivity. Information revealed the limitations of the diagnosis, and it demonstrated the little knowledge of the medical community about this disease. In Colombia, there is no clear policy regarding this occupational zoonosis. Brucellosis is mentioned only in Decree 2566 of 2009, in which the new table of occupational diseases is established. The paper concludes that human brucellosis in Colombia is an underdiagnosed, and therefore underreported, disease since there is no mandatory reporting system on the subject.

  2. Impacts of a change in vegetation description on simulated European summer present-day and future climates

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez, E.; Gaertner, M.A.; Gallardo, C.; Padorno, E.; Castro, M. [Universidad de Castilla-La Mancha (UCLM), Facultad de Ciencias del Medio Ambiente, Toledo (Spain); Arribas, A. [Universidad de Castilla-La Mancha (UCLM), Facultad de Ciencias del Medio Ambiente, Toledo (Spain); Met Office, Exeter, Devon (United Kingdom)

    2007-08-15

    This paper analyzes the soil-atmosphere feedbacks and uncertainties under current (1960-1990) and plausible future climate conditions (2070-2100, using the A2 greenhouse gases emission scenario). For this purpose, two vegetation descriptions differing only in the grassland and grass-with-trees proportion in some parts of the domain have been created. The combination of these two different climate scenarios and two vegetation descriptions defines four different 30-year experiments, which have been completed using a regional climate model. The domain is centered around the Mediterranean basin and covers most of Europe. The study focuses on the summer season when there are major differences between the two vegetation descriptions and when the impact of land-surface processes on precipitation is largest. Present climate experiments show large evapotranspiration differences over areas where vegetation changes have taken place. Precipitation increases (up to 3 mm day{sup -1} in some regions) follow evapotranspiration increases, although with a more complex spatial structure. These results indicate a high sensitivity at regional scales of summer precipitation processes to vegetation changes. Future climate simulations show very similar changes to those observed in the current climate experiments. This indicates that the impacts of climate change are relatively independent to the land-cover descriptions used in this study. (orig.)

  3. Systematic organization of medicinal plant information: a monograph template proposal

    Directory of Open Access Journals (Sweden)

    Ana C.B. Carvalho

    2014-01-01

    Full Text Available The use of medicinal plants in Brazil is widespread and is supported by public policies; it has the objective of providing the population with safe and effective herbal medicines of adequate quality. An action in these policies is to develop medicinal plant monographs to gather published information and decide which medicinal plants should be financed by the Brazilian government and distributed by the public health system. Currently, the monographs published worldwide do not present unified information regarding medicinal plants, and generally, they do not cover enough requirements for herbal medicine registration. The aim of this study is to develop a monograph model with standardized information not only about botany, agronomy, quality control, safety, and efficacy but also about relating regulatory aspects that support herbal medicine regulation. The development of standardized monographs favors the fast authorization and distribution of herbal medicines in the public system. The model also points out the lacking studies that should be carried out to supplement the necessary regulatory information of medicinal plants.

  4. A descriptive study of women presenting to an obstetric triage unit with no prenatal care.

    Science.gov (United States)

    Knight, Erin; Morris, Margaret; Heaman, Maureen

    2014-03-01

    To describe women presenting to an obstetric triage unit with no prenatal care (PNC), to identify gaps in care, and to compare care provided to World Health Organization (WHO) standards. We reviewed the charts of women who gave birth at Women's Hospital in Winnipeg and were discharged between April 1, 2008, and March 31, 2011, and identified those whose charts were coded with ICD-10 code Z35.3 (inadequate PNC) or who had fewer than 2 PNC visits. Three hundred eighty-two charts were identified, and sociodemographic characteristics, PNC history, investigations, and pregnancy outcomes were recorded. The care provided was compared with WHO guidelines. One hundred nine women presented to the obstetric triage unit with no PNC; 96 (88.1%) were in the third trimester. Only 39 women (35.8%) received subsequent PNC, with care falling short of WHO standards. Gaps in PNC included missing time-sensitive screening tests, mid-stream urine culture, and Chlamydia and gonorrhea testing. The mean maternal age was 26.1 years, and 93 women (85.3%) were multigravidas. More than one half of the women (51.4%) were involved with Child and Family Services, 64.2% smoked, 33.0% drank alcohol, and 32.1% used illicit drugs during pregnancy. Two thirds of the women (66.2%) lived in inner-city Winnipeg. Only 63.0% of neonates showed growth appropriate for gestational age. Two pregnancies ended in stillbirth; there was one neonatal death, and over one third of the births were preterm. Most women who present with no PNC do so late in pregnancy, proceed to deliver with little or no additional PNC, and have high rates of adverse outcomes. Thus, efforts to improve PNC must focus on facilitating earlier entry into care. This would also improve compliance with WHO guidelines for continuing care. Treatment protocols could improve gaps in obtaining urine culture and in Chlamydia and gonorrhea testing.

  5. Spent Fuel Test-Climax: technical measurements data management system description and data presentation

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, R.C.

    1985-08-01

    The Spent Fuel Test-Climax (SFT-C) was located 420 m below surface in the Climax Stock granite on the Nevada Test Site. The test was conducted under the technical direction of the Lawrence Livermore National Laboratory (LLNL) as part of the Nevada Nuclear Waste Storage Investigations (NNWSI) for the US Department of Energy. Eleven canisters of spent nuclear reactor fuel were emplaced, along with six electrical simulators, in April-May 1980. The spent fuel canisters were retrieved and the electrical simulators de-energized in March-April 1983. During the test, just over 1000 MW-hr of thermal energy was deposited in the site, causing temperature changes 100{sup 0}C near the canisters, and about 5{sup 0} in the tunnels. More than 900 channels of geotechnical, seismological, and test status data were recorded on nearly continuous basis for about 3-1/2 years, ending in September 1983. Most geotechnical instrumentation was known to be temperature sensitive, and thus would require temperature compensation before interpretation. Accordingly, a 10-in. reel of digital tape was off-loaded and shipped to Livermore every 4 to 8 weeks, where the data were verified, organized into 45 one-million-word files, and temperature corrected. The purpose of this report is to document the receipt and processing of the data by LLNL Livermore personnel, present facts about the history of the instruments which may be important to the interpretation of the data, present the data themselves in graphical form for each instrument over its operating lifetime, document the forms and locations in which the data will be archived, and offer the data to the geotechnical community for future use in understanding and predicting the effects of the storage of heat-generating waste in hard rocks such as granite.

  6. Experience of a monographic tuberculosis unit: the first 500 cases.

    Science.gov (United States)

    González-Moreno, Juan; García-Gasalla, Mercedes; Cifuentes Luna, Carmen; Mir Villadrich, Isabel; Pareja Bezares, Antonio; Navarro Fernández, Verónica; Serrano Bujalance, Araceli; Pérez Seco, M Cruz; Payeras Cifre, Antonio

    2013-10-01

    Tuberculosis (TB) remains a highly prevalent and potentially severe disease. However, since 2002 the annual incidence has been decreasing both worldwide and in Spain, where the incidence varies widely between regions. The main objective of this study is to describe the experience of a monographic TB unit in a second level hospital. A descriptive study was carried out which included all cases of TB diagnosed in a monographic unit of a secondary hospital between 2003 and 2011. Demographic, clinical, epidemiological and microbiological data were recorded. We analyzed 500 TB cases and found an increasing annual incidence in all subgroups, including native and immigrant populations. Most cases (63.8%) were male, with a median age of 36 years (range 8 months-90 years). In total, 39.8% of patients were foreign born. Coinfection with human immunodeficiency virus was found in 11% of cases. The pulmonary form was most frequently diagnosed (63.8%). Overall mortality was 5.8% with no significant differences between groups (including foreign born and human immunodeficiency virus positive patients). Although TB incidence is globally decreasing, in our study we found an increasing number of cases in recent years in all subgroups, which can be explained by this being a monographic unit with an intensive contact tracing program. Copyright © 2012 SEPAR. Published by Elsevier Espana. All rights reserved.

  7. A monograph of the African Squirrels, with an enumeration of the specimens in the Leyden Museum

    NARCIS (Netherlands)

    Jentink, F.A.

    1882-01-01

    The African Squirrels have never been monographically studied, although a large number of more or less important descriptions of different species have been given, which are to be found in different periodicals. The late Temminck in his »Esquisses zoologiques sur la côte de Guiné. 1853” was the firs

  8. Force Limited Vibration Testing Monograph

    Science.gov (United States)

    Scharton, Terry D.

    1997-01-01

    The practice of limiting the shaker force in vibration tests was investigated at the NASA Jet Propulsion Laboratory (JPL) in 1990 after the mechanical failure of an aerospace component during a vibration test. Now force limiting is used in almost every major vibration test at JPL and in many vibration tests at NASA Goddard Space Flight Center (GSFC) and at many aerospace contractors. The basic ideas behind force limiting have been in the literature for several decades, but the piezo-electric force transducers necessary to conveniently implement force limiting have been available only in the last decade. In 1993, funding was obtained from the NASA headquarters Office of Chief Engineer to develop and document the technology needed to establish force limited vibration testing as a standard approach available to all NASA centers and aerospace contractors. This monograph is the final report on that effort and discusses the history, theory, and applications of the method in some detail.

  9. Socio Demographic Profile and Clinical Presentation of Collagen Vascular Disease with Pulmonary Symptoms: A Descriptive Cross Sectional Study

    Directory of Open Access Journals (Sweden)

    Parul Vadgama

    2013-02-01

    Full Text Available Introduction: Collagen Vascular Disease presented with varied systemic symptoms including pulmonary symptoms, commonly breathless on exertion; dry cough; cough with expectoration; chest pain; and hemoptysis. The current study was conducted to know socio demographic profile and clinical presentation of patient coming with Collagen Vascular Disease having pulmonary symptoms. Methodology: This was a descriptive cross sectional study conducted among Collagen Vascular Disease patient coming with pulmonary symptoms in outpatient department. Results: Among the 50 patients 40% patients were having SC followed by SLE (30%. Most common age group was 31 to 40 year of age followed by 21 to 30 year of age. Both these group contribute more than half of the cases. Eighty percent patients were female with female to male ratio was 4:1. The most common chest symptom in the patients was breathlessness (50% and fatigue (50%, followed by cough (46% and chest pain (18%. The most common sign was Crackles (32% followed by clubbing in 22% of patients. Conclusion: Female and young - middle age more commonly presented with Collagen Vascular Disease. Most of the patients when presented were having wide-ranging pulmonary symptoms-signs indicating extensive involvement of lung tissues which emphasis need for early diagnosis and treatment. [Natl J of Med Res 2013; 3(1.000: 27-29

  10. The Pharmacokinetics of Second-Generation Long-Acting Injectable Antipsychotics: Limitations of Monograph Values.

    Science.gov (United States)

    Lee, Lik Hang N; Choi, Charles; Collier, Abby C; Barr, Alasdair M; Honer, William G; Procyshyn, Ric M

    2015-12-01

    Product monographs (also known by terms such as Summary of Product Characteristics and Highlights of Prescribing Information, depending on the jurisdiction) provide essential information to ensure the safe and effective use of a drug. Medical practitioners often rely on these monographs for guidance on matters related to pharmacokinetics as well as indications, contraindications, clinical pharmacology, and adverse reactions. The clinical and scientific information found within these documents, forming the basis for decision making, are presumed to be derived from well-designed studies. The objective of this review is to examine the source and validity of the pharmacokinetic data used in establishing the half-lives and times to steady-state reported in the product monographs of second-generation long-acting injectable antipsychotics. Thus, we have critically evaluated the clinical trials from which the pharmacokinetic parameters listed in the product monographs were determined. In many cases, the pharmacokinetic information presented in product monographs is of limited use to clinicians wishing to optimize the effectiveness and tolerability of second-generation long-acting injectable antipsychotics. Under such circumstances, off-label prescribing practices may actually produce better clinical outcomes than if decisions were made based on the product monographs alone.

  11. Three Evidence Based Methods to Compensate for a Lack of Subject Background when Ordering Chemistry Monographs

    Directory of Open Access Journals (Sweden)

    Robert A. Wright

    2008-09-01

    Full Text Available Objective – The aim of this article is to present evidence based methods for the selection of chemistry monographs, particularly for librarians lacking a background in chemistry. These methods will be described in detail, their practical application illustrated, and their efficacy tested by analyzing circulation data.Methods – Two hundred and ninety-five chemistry monographs were selected between 2005 and 2007 using rigorously-applied evidence based methods involving the Library's integrated library system (ILS, Google, and SciFinder Scholar. The average circulation rate of this group of monographs was compared to the average circulation rate of 254 chemistry monographs selected between 2002 and 2004 when the methods were not used or were in an incomplete state of development.Results – Circulations/month were on average 9% greater in the cohort of monographs selected with the rigorously-applied evidence based methods. Further statistical analysis, however, finds that this result can not be attributed to the different application of these methods. Conclusion – The methods discussed in this article appear to provide an evidence base for the selection of chemistry monographs, but their application does not change circulation rates in a statistically significant way. Further research is needed to determine if this lack of statistical significance is real or a product of the organic development and application of these methods over time, making definitive comparisons difficult.

  12. Descriptive analysis of context evaluation instrument for technical oral presentation skills evaluation: A case study in English technical communication course

    Science.gov (United States)

    Mohamed, Abdullah-Adnan; Asmawi, Adelina; Hamid, Mohd Rashid Ab; Mustafa, Zainol bin

    2015-02-01

    This paper reports a pilot study of Context Evaluation using a self-developed questionnaire distributed among engineering undergraduates at a university under study. The study aims to validate the self-developed questionnaires used in the Context evaluation, a component in the CIPP Model. The Context evaluation assesses background information for needs, assets, problems and opportunities relevant to beneficiaries of the study in a defined environment. Through the questionnaire, background information for the assessment of needs, assets and problems related to the engineering undergraduates' perceptions on the teaching and learning of technical oral presentation skills was collected and analysed. The questionnaire was developed using 5-points Likert scale to measure the constructs under study. They were distributed to 100 respondents with 79 returned. The respondents consisted of engineering undergraduates studied at various faculties at one technical university in Malaysia. The descriptive analysis of data for each item which makes up the construct for Context evaluation is found to be high. This implied that engineering undergraduates showed high interest in teaching and learning of technical oral presentation skills, thus their needs are met. Also, they agreed that assets and facilities are conducive to their learning. In conclusion, the context evaluation involving needs and assets factors are both considerably important; their needs are met and the assets and facilities do support their technical oral presentation skills learning experience.

  13. NTP monograph on health effects of low-level lead.

    Science.gov (United States)

    2012-06-01

    Although reductions in lead (Pb) exposure for the U.S. population have resulted in lower blood Pb levels over time, epidemiological studies continue to provide evidence of health effects at lower and lower blood Pb levels. Low-level Pb was selected for evaluation by the National Toxicology Program (NTP) because of (1) the availability of a large number of epidemiological studies of Pb, (2) a nomination by the National Institute for Occupational Safety and Health for an assessment of Pb at lower levels of exposure, and (3) public concern for effects of Pb in children and adults. This evaluation summarizes the evidence in humans and presents conclusions on health effects in children and adults associated with low-level Pb exposure as indicated by less than 10 micrograms of Pb per deciliter of blood (Monograph on Health Effects of Low-Level Lead. The document and appendices are available at http://ntp.niehs.nih.gov/go/evals. This document provides background on Pb exposure and includes a review of the primary epidemiological literature for evidence that low-level Pb is associated with neurological, immunological, cardiovascular, renal, and/or reproductive and developmental effects. The NTP Monograph presents specific conclusions for each health effect area. Overall, the NTP concludes that there is sufficient evidence that blood Pb levels Monograph on November 17-18, 2011 (http://ntp.niehs.nih.gov/go/37090.

  14. Monograph of Keçiören Municipality

    Directory of Open Access Journals (Sweden)

    Savaş Zafer Şahin

    2015-12-01

    Full Text Available In Turkey, urban administration can be defined from a judicial perspective as the bundle of powers vested in municipalities. It is known that throughout republican history, municipalities, using these powers, have differentiated themselves via their own internal dynamics in parallel to the evolution of public policy and changes in legislation. Yet, it is obvious that there are important gaps in understanding this differentiation taking into consideration the structural conditions of individual municipalities. In particular, in order to thoroughly understand municipalities, it is important to consider periodical pictures of how each municipality has been affected by waves of decentralization and centralization experienced over the last thirty years. In this respect, this monograph, using the same monographic approach developed for the Çankaya Municipality, provides a picture of the existing situation of Ankara’s Keçiören Municipality and presents related problems and potential. This monograph, based on qualitative and quantitative research, presents a holistic evaluation of Keçiören Municipality in terms of its external environment, provision of services, decision-making processes, use of technology and communications.

  15. Software for predictive microbiology and risk assessment: a description and comparison of tools presented at the ICPMF8 Software Fair.

    Science.gov (United States)

    Tenenhaus-Aziza, Fanny; Ellouze, Mariem

    2015-02-01

    The 8th International Conference on Predictive Modelling in Food was held in Paris, France in September 2013. One of the major topics of this conference was the transfer of knowledge and tools between academics and stakeholders of the food sector. During the conference, a "Software Fair" was held to provide information and demonstrations of predictive microbiology and risk assessment software. This article presents an overall description of the 16 software tools demonstrated at the session and provides a comparison based on several criteria such as the modeling approach, the different modules available (e.g. databases, predictors, fitting tools, risk assessment tools), the studied environmental factors (temperature, pH, aw, etc.), the type of media (broth or food) and the number and type of the provided micro-organisms (pathogens and spoilers). The present study is a guide to help users select the software tools which are most suitable to their specific needs, before they test and explore the tool(s) in more depth. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. A monograph of Otidea (Pyronemataceae, Pezizomycetes).

    Science.gov (United States)

    Olariaga, I; Van Vooren, N; Carbone, M; Hansen, K

    2015-12-01

    The easily recognised genus Otidea is subjected to numerous problems in species identification. A number of old names have undergone various interpretations, materials from different continents have not been compared and misidentifications occur commonly. In this context, Otidea is monographed, based on our multiple gene phylogenies assessing species boundaries and comparative morphological characters (see Hansen & Olariaga 2015). All names combined in or synonymised with Otidea are dealt with. Thirty-three species are treated, with full descriptions and colour illustrations provided for 25 of these. Five new species are described, viz. O. borealis, O. brunneoparva, O. oregonensis, O. pseudoleporina and O. subformicarum. Otidea cantharella var. minor and O. onotica var. brevispora are elevated to species rank. Otideopsis kaushalii is combined in the genus Otidea. A key to the species of Otidea is given. An LSU dataset containing 167 sequences (with 44 newly generated in this study) is analysed to place collections and determine whether the named Otidea sequences in GenBank were identified correctly. Fourty-nine new ITS sequences were generated in this study. The ITS region is too variable to align across Otidea, but had low intraspecific variation and it aided in species identifications. Thirty type collections were studied, and ITS and LSU sequences are provided for 12 of these. A neotype is designated for O. cantharella and epitypes for O. concinna, O. leporina and O. onotica, along with several lectotypifications. The apothecial colour and shape, and spore characters are important for species identification. We conclude that to distinguish closely related or morphologically similar species, a combination of additional features are needed, i.e. the shape of the paraphyses, ectal excipulum structure, types of ectal excipulum resinous exudates and their reactions in Melzer's reagent and KOH, tomentum and basal mycelium colours and exudates. The KOH reaction of

  17. Preface to the third monograph

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2004-05-01

    Full Text Available Fashions come and go. Filmstars have their hey days and sink into oblivion. Technological gadgets become outdated sometimes even before they enter the market. Everyone wants the latest in TVs, computers, mobiles, cars, household appliances, industrial machinery, the works.We want to hear the latest news. Nobody prefers to read yesterday's newspaper today out of choice. We also want to read the latest edition of a book, and look up recent references and research work.We want the latest in treatments as well. The most recent is always considered an advancement over what was available earlier. Newer therapies, newer investigations, newer procedures.But, at the some time, we want to go to the senior consultant. And, given a choice, the older the better. Even elsewhere, we do not go to the junior most person to solve our problems if we can approach the senior man, and he is amenable. The recent graduate or postgraduate has the latest information, but it is the senior man who sits on the panel of examiners.We want the most recent in some cases, and the older and more experienced in others. Why should this happen? How should we handle our great need to update our knowledge on the latest, and yet not neglect the old and time-tested?This dilemma occurs in the research field as well, and psychiatry is no exception.What can be a healthy way of resolving this issue is the subject matter of this monograph.

  18. A monograph assignment as an integrative application of evidence-based medicine and pharmacoeconomic principles.

    Science.gov (United States)

    Law, Anandi V; Jackevicius, Cynthia A; Bounthavong, Mark

    2011-02-10

    To describe the development and assessment of monographs as an assignment to incorporate evidence-based medicine (EBM) and pharmacoeconomic principles into a third-year pharmacoeconomic course. Eight newly FDA-approved drugs were assigned to 16 teams of students, where each drug was assigned to 2 teams. Teams had to research their drug, write a professional monograph, deliver an oral presentation, and answer questions posed by faculty judges. One team was asked to present evidence for inclusion of the drug into a formulary, while another team presented evidence against inclusion. The teams' average score on the written report was 99.1%; on the oral presentation, 92.5%, and on the online quiz given at the end of the presentations, 77%. Monographs are a successful method of incorporating and integrating learning across different concepts, as well as increasing relevance of pharmacoeconomics in the PharmD curriculum.

  19. Preface to the seventh monograph

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2005-01-01

    Full Text Available Like all good neighbours, competing schools of psychiatry claw at each other. Like all good samaritans, some people try to play arbiters and douse the fires. The tradition of fights and retaliation is not new to psy­chiatry, neither is it unique to the branch. Competing schools of thought exist almost everywhere. And it is tempting to say that the more intellec­tually robust a field, the greater the controversies and fights in it.In fact if intellectuals were to come together and not voice differences, either they are not intellectuals, or they have no opinions. (Or they may be simply scared, or silenced for other reasons.Ofcourse we must note that while in other fields of thought there can be controversies, there is one essential difference. They may not be dealing with patients and their lives. And to that the corollary is that psychiatric controversies should not be carried out at the expense of patient welfare.Having said that, let us also note that when there are fights, arbiters become very active. As do advocates, of one or the other approach.In this monograph we have tried to act the arbiters. Maybe because it is appropriate. Maybe also because that's the only thing we can do (and may be do well: atleast that's what we would love to believe.Why not advocates ? Well, for one, there are so many already. For another, we run the risk of doing a poor job of it.Not that we have necessarily done a good job of being arbiters.

  20. A descriptive study of hand injuries presenting to the adult emergency department of a tertiary care center in urban India

    Science.gov (United States)

    Ghiya, Murtuza N.; Murty, Shakuntala; Shetty, Naren; D'Cunha, Rodney

    2017-01-01

    Background: Despite having a dedicated Plastic Surgery Unit, emergency physicians (EPs) manage many of the acute, traumatic hand injuries. Further very minimal information exists about the extent to which tetanus recommendations as per Advisory Committee on Immunization Practices are followed in emergency departments (EDs). Furthermore, the management of pain is often neglected. Objectives: To provide a clinical description of hand injuries with etiology and mechanism; and describe the trends of ED management, including analgesia and tetanus prophylaxis. Methodology: Records of eighty patients with hand injuries were reviewed. SPSS version 18 was used for statistical analysis. Wilcoxon signed rank test, and Pearson Chi-square test were used to compare left with right-hand injuries and validate associations, respectively. Results: The mean age of the patients was 27.41 years and median delay in presentation was 2 h. Occupational injury was the predominant mode of injury (74%) most patients (59 of the 86) received intravenous analgesia; while very few (6) received local anesthesia and (24) received no analgesia at all. A majority of patients (56) received tetanus toxoid prophylaxis, while only four patients (4.6%) also received tetanus immunoglobulin intramuscular. Most patients (71%) were admitted, while only a small number of patients (14%) were discharged from the ED. Conclusion: Proper training and sensitization towards the need and technique of anesthesia (particularly local anesthesia) would improve the quality of patient care. Printed guidelines and periodic review of the charts would help to overcome poor adherence to tetanus prophylaxis. Hand injuries could be managed better by the EP, with training through rotations to the Plastic Surgery Unit.

  1. A descriptive study of hand injuries presenting to the adult emergency department of a tertiary care center in urban India

    Directory of Open Access Journals (Sweden)

    Murtuza N Ghiya

    2017-01-01

    Full Text Available Background: Despite having a dedicated Plastic Surgery Unit, emergency physicians (EPs manage many of the acute, traumatic hand injuries. Further very minimal information exists about the extent to which tetanus recommendations as per Advisory Committee on Immunization Practices are followed in emergency departments (EDs. Furthermore, the management of pain is often neglected. Objectives: To provide a clinical description of hand injuries with etiology and mechanism; and describe the trends of ED management, including analgesia and tetanus prophylaxis. Methodology: Records of eighty patients with hand injuries were reviewed. SPSS version 18 was used for statistical analysis. Wilcoxon signed rank test, and Pearson Chi-square test were used to compare left with right-hand injuries and validate associations, respectively. Results: The mean age of the patients was 27.41 years and median delay in presentation was 2 h. Occupational injury was the predominant mode of injury (74% most patients (59 of the 86 received intravenous analgesia; while very few (6 received local anesthesia and (24 received no analgesia at all. A majority of patients (56 received tetanus toxoid prophylaxis, while only four patients (4.6% also received tetanus immunoglobulin intramuscular. Most patients (71% were admitted, while only a small number of patients (14% were discharged from the ED. Conclusion: Proper training and sensitization towards the need and technique of anesthesia (particularly local anesthesia would improve the quality of patient care. Printed guidelines and periodic review of the charts would help to overcome poor adherence to tetanus prophylaxis. Hand injuries could be managed better by the EP, with training through rotations to the Plastic Surgery Unit.

  2. 21 CFR 330.11 - NDA deviations from applicable monograph.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false NDA deviations from applicable monograph. 330.11... EFFECTIVE AND NOT MISBRANDED Administrative Procedures § 330.11 NDA deviations from applicable monograph. A new drug application requesting approval of an OTC drug deviating in any respect from a monograph that...

  3. An Exploratory Descriptive Study of Antimicrobial Resistance Patterns of Staphylococcus Spp. Isolated from Horses Presented at a Veterinary Teaching Hospital.

    Science.gov (United States)

    Oguttu, James Wabwire; Qekwana, Daniel Nenene; Odoi, Agricola

    2017-08-22

    Antimicrobial resistant Staphylococcus are becoming increasingly important in horses because of the zoonotic nature of the pathogens and the associated risks to caregivers and owners. Knowledge of the burden and their antimicrobial resistance patterns are important to inform control strategies. This study is an exploratory descriptive investigation of the burden and antimicrobial drug resistance patterns of Staphylococcus isolates from horses presented at a veterinary teaching hospital in South Africa. Retrospective laboratory clinical records of 1027 horses presented at the University of Pretoria veterinary teaching hospital between 2007 and 2012 were included in the study. Crude and factor-specific percentages of Staphylococcus positive samples, antimicrobial resistant (AMR) and multidrug resistant (MDR) isolates were computed and compared across Staphylococcus spp., geographic locations, seasons, years, breed and sex using Chi-square and Fisher's exact tests. Of the 1027 processed clinical samples, 12.0% were Staphylococcus positive. The majority of the isolates were S. aureus (41.5%) followed by S. pseudintermedius (14.6%). Fifty-two percent of the Staphylococcus positive isolates were AMR while 28.5% were MDR. Significant (p < 0.05) differences in the percentage of samples with isolates that were AMR or MDR was observed across seasons, horse breeds and Staphylococcus spp. Summer season had the highest (64.3%) and autumn the lowest (29.6%) percentages of AMR isolates. Highest percentage of AMR samples were observed among the Boerperds (85.7%) followed by the American saddler (75%) and the European warm blood (73.9%). Significantly (p < 0.001) more S. aureus isolates (72.5%) were AMR than S. pseudintermedius isolates (38.9%). Similarly, significantly (p < 0.001) more S. aureus (52.9%) exhibited MDR than S. pseudintermedius (16.7%). The highest levels of AMR were towards β-lactams (84.5%) followed by trimethoprim/sulfamethoxazole (folate pathway inhibitors

  4. Presentation

    Directory of Open Access Journals (Sweden)

    Paulo Henrique Freire Vieira

    2013-12-01

    Full Text Available This dossier focuses on one of the essential debate topics today about the territorial dimension of the new development strategies concerned with the worsening of the global socioecological crisis, that is: the challenges related to the activation and integration in networks of localized agri-food systems. For its composition, some contributions presented and debated during the VI International Conference on Localized Agri-food System - The LAFS facing the opportunities and challenges of the new global context have been gathered. The event took place in the city of Florianópolis, from May 21th to 25th of 2013. The event was promoted by the Federal University of Santa Catarina (UFSC and by the Center for the International Cooperation on Agricultural Research for Development (CIRAD. Besides UFSC and CIRAD, EPAGRI, State University of Santa Catarina (UDESC, as well as research institutes and universities from other states (UFMG, IEA/SP, UFS, UFRGS and Mexican and Argentinian partners from the RED SIAL Latino Americana also participated in the organization of lectures, discussion tables and workshops.

  5. Bibliometrics of NIHR HTA monographs and their related journal articles.

    Science.gov (United States)

    Royle, Pamela; Waugh, Norman

    2015-02-18

    A bibliometric analysis of the UK National Institute for Health Research (NIHR) Health Technology Assessment (HTA) monographs and their related journal articles by: (1) exploring the differences in citations to the HTA monographs in Google Scholar (GS), Scopus and Web of Science (WoS), and (2) comparing Scopus citations to the monographs with their related journal articles. A study of 111 HTA monographs published in 2010 and 2011, and their external journal articles. Citations to the monographs in GS, Scopus and WoS, and to their external journal articles in Scopus. The number of citations varied among the three databases, with GS having the highest and WoS the lowest; however, the citation-based rankings among the databases were highly correlated. Overall, 56% of monographs had a related publication, with the highest proportion for primary research (76%) and lowest for evidence syntheses (43%). There was a large variation in how the monographs were cited, compared to journal articles, resulting in more frequent problems, with unlinked citations in Scopus and WoS. When comparing differences in the number of citations between monograph publications with their related journal articles from the same project, we found that monographs received more citations than their journal articles for evidence syntheses and methodology projects; by contrast, journal articles related to primary research monographs were more highly cited than their monograph. The numbers of citations to the HTA monographs differed considerably between the databases, but were highly correlated. When a HTA monograph had a journal article from the same study, there were more citations to the journal article for primary research, but more to the monographs for evidence syntheses. Citations to the related journal articles were more reliably recorded than citations to the HTA monographs. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please

  6. Presentation

    Directory of Open Access Journals (Sweden)

    Eduardo Vicente

    2013-06-01

    Full Text Available In the present edition of Significação – Scientific Journal for Audiovisual Culture and in the others to follow something new is brought: the presence of thematic dossiers which are to be organized by invited scholars. The appointed subject for the very first one of them was Radio and the invited scholar, Eduardo Vicente, professor at the Graduate Course in Audiovisual and at the Postgraduate Program in Audiovisual Media and Processes of the School of Communication and Arts of the University of São Paulo (ECA-USP. Entitled Radio Beyond Borders the dossier gathers six articles and the intention of reuniting works on the perspectives of usage of such media as much as on the new possibilities of aesthetical experimenting being build up for it, especially considering the new digital technologies and technological convergences. It also intends to present works with original theoretical approach and original reflections able to reset the way we look at what is today already a centennial media. Having broadened the meaning of “beyond borders”, four foreign authors were invited to join the dossier. This is the first time they are being published in this country and so, in all cases, the articles where either written or translated into Portuguese.The dossier begins with “Radio is dead…Long live to the sound”, which is the transcription of a thought provoking lecture given by Armand Balsebre (Autonomous University of Barcelona – one of the most influential authors in the world on the Radio study field. It addresses the challenges such media is to face so that it can become “a new sound media, in the context of a new soundscape or sound-sphere, for the new listeners”. Andrew Dubber (Birmingham City University regarding the challenges posed by a Digital Era argues for a theoretical approach in radio studies which can consider a Media Ecology. The author understands the form and discourse of radio as a negotiation of affordances and

  7. Presentation

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    Helmut Renders

    2008-10-01

    Full Text Available We present to our esteemed readers the second edition of our journal for 2008. We have chosen the theme “The life and work of Prof. Dr. Jürgen Moltmann” as its special emphasis. It is our way to pay homage to J. Moltmann in the year the Universidade Metodista de São Paulo awards him an honorary Doctor Honoris Causa degree. Sincethe seventies, Moltmann and Latin America have been in dialog. In his emblematic work “A Theology of Liberation”, Gustavo Gutiérrez, the Catholic, discussed with Moltmann, the Reformed, the relationship between eschatology and history (GUTIÉRREZ, Gustavo.Teologia da Libertação. 5ª edição. Petrópolis, RJ: Vozes, 1985, p. 27, 137-139. A dialog held in the premises of IMS, which nowadays is called UMESP, has produced the little book “Passion for life” (MOLTMANN, Jürgen. Paixão pela vida. São Paulo, SP: ASTE - Associaçãode Seminários Teológicos Evangélicos, 1978.In the following years, the wide theological work of J. Moltmann went all the way from debates to congresses and has conquered the classrooms. Most probably, J. Moltmann is nowadays the most widely read European author in Brazilian theological seminaries. Thisrecognition can only be held in unison and the wide response to our request for articles confirms the huge repercussion that Moltmann’s work has been having up to today in Brazil. The ecumenical theologian J. Moltmann is ecumenically read. We believe that thisway we may be better equipped to answer to anyone who asks us for the reason there is hope in us. We have organized the articles on J. Moltmann’s theology according to the original publication date of the books dealt with in each essay. We also communicate that some articles which were originally requested for this edition of the journal will be published in the journal Estudos de Regilião in May 2009.As it is usual with the journal Caminhando, we have, besides this thematic emphasis, yet other contributions in the areas of

  8. Presentation

    Directory of Open Access Journals (Sweden)

    Nicanor Lopes

    2010-11-01

    Full Text Available The Journal Caminhando debuts with a new editorial format: eachmagazine will have a Dossier.In 2010 Christianity celebrated the centenary of Edinburgh. TheWorld Missionary Conference in Edinburgh in 1910 is regarded by manyas missiological watershed in the missionary and ecumenical movement.So the Faculty of Theology of the Methodist Church (FATEO decidedto organize a Wesleyan Week discussing the issue of mission. For anevent of this magnitude FATEO invited the Rev. Dr. Wesley Ariarajah,Methodist pastor and teacher of Sri Lanka with extensive experience inpastoral ministry in local churches and professor of History of Religionsand the New Testament at the Theological College of Lanka, maintainedby the Protestant Churches in Sri Lanka. In 1981 he was invited to jointhe World Council of Churches, where he presided for over ten years theCouncil of Interreligious Dialogue. From 1992 he served as Deputy GeneralSecretary of the WCC.The following texts are not the speeches of the Rev. Dr. WesleyAriarajah, for they will be published separately. Nevertheless, the journaldialogs with the celebrations of the centenary of Edinburgh, parting formthe intriguing theme: "Mission in the 21st century in Brazil". After all, howis it that mission takes place among us in personal, church, and communityactivities?Within the Dossier, as common to the journal, the textos are organizedas follows: Bible, Theology / History and Pastoral Care. Other items thatdo not fit within the Dossier, but, do articulate mission, can be found inthe section Declarations and Documents and Book Reviews.The authors of the Dossier have important considerations in buildinga contemporary missiological concept considering Brazilian reality.Anderson de Oliveira, in the Bible-Section, presents a significantexegeses of Matthew 26.6-13. What does it mean when Jesus is quotedwith the words: "For the poor always ye have with you, but me ye havenot always." Is this declaration challenging the gospels

  9. When Teachers Lead. UCEA Monograph Series.

    Science.gov (United States)

    Astuto, Terry A., Ed.

    This document contains six chapters that examine the role of teacher leadership in the school-restructuring process. Chapter 1, "When--Teachers Lead" (Bruce S. Cooper), provides a general introduction to the content and purpose of the monograph. Chapter 2, "When--Teachers Share School-Level Decision-Making" (Sharon Conley and Justo Robles),…

  10. The Self Perception of Male and Female Homosexuals. Criminal Justice Monograph: Vol. 6, No. 3.

    Science.gov (United States)

    Sisson, William Henry, III

    This monograph presents a historical and theoretical review of homosexuality followed by a study of the self-perception of homosexuals. History bears out that homosexuality has always been one aspect of human sexuality and was more prominent in other periods of human history, depending on societal attitudes and mores. At present, many authors…

  11. Structural and functional models in molybdenum and tungsten bioinorganic chemistry: description of selected model complexes, present scenario and possible future scopes.

    Science.gov (United States)

    Majumdar, Amit

    2014-06-28

    A brief description about some selected model complexes in molybdenum and tungsten bioinorganic chemistry is provided. The synthetic strategies involved and their limitations are discussed. Current status of molybdenum and tungsten bioinorganic modeling chemistry is presented briefly and synthetic problems associated therein are analyzed. Possible future directions which may expand the scope of modeling chemistry are suggested.

  12. Place as Text: Approaches to Active Learning. 2nd Edition. National Collegiate Honors Council Monograph Series

    Science.gov (United States)

    Braid, Bernice, Ed.; Long, Ada, Ed.

    2010-01-01

    The decade since publication of "Place as Text: Approaches to Active Learning" has seen an explosion of interest and productivity in the field of experiential education. This monograph presents a story of an experiment and a blueprint of sorts for anyone interested in enriching an existing program or willing to experiment with pedagogy…

  13. Recent Advances in Nutrition Education. The Health Education Monograph Series. Volume 15 Number 3.

    Science.gov (United States)

    Shier, Nathan W., Ed.; Torabi, Mohammad R., Ed.

    This monograph presents a collection of articles on nutrition education: "Using the DINE Score To Improve Food Choice Behavior" (Darwin Dennison and Kathryn F. Dennison); "Self-Reported Food Intake Patterns of Older Adults in Australia, China, and the United States" (Alyce D. Fly, Nathan W Shier, Barbara A. Hawkins, Susan J.…

  14. The Aeronautics Education, Research, and Industry Alliance (AERIAL) 2002 Report. UNO Aviation Monograph Series. UNOAI Report.

    Science.gov (United States)

    Bowen, Brent D.; Box, Richard C.; Fink, Mary M.; Gogos, George; Lehrer, Henry R.; Narayanan, Ram M.; Nickerson, Jocelyn S.; O'Neil, Patrick D.; Tarry, Scott E.; Vlasek, Karisa D.

    This document contains four papers on aeronautics education, research, and partnerships that partly supported through the Aeronautics Education, Research, and Industry Alliance (AERIAL). The paper "2002 AERIAL Monograph" (Brent D. Bowen, Jocelyn S. Nickerson, Mary M. Fink, et al.) presents an overview of research and development in the…

  15. Cuento Therapy. Folktales as a Culturally Sensitive Psychotherapy for Puerto Rican Children. Monograph No. 12.

    Science.gov (United States)

    Constantino, Giuseppe; And Others

    A seven-year project developing and testing cuento therapy, a form of child psychotherapy in which Puerto Rican mothers recount to their children folktales taken from Puerto Rican culture, is described and evaluated in this monograph. Chapter 1 explains how the research presented in later chapters fits into substantially broader patterns of…

  16. 76 FR 51034 - Availability of Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy...

    Science.gov (United States)

    2011-08-17

    ... HUMAN SERVICES Availability of Draft NTP Monograph on Potential Developmental Effects of Cancer... Monograph AGENCY: Division of the National Toxicology Program (DNTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health. ACTION: Availability of Draft Monograph; Request...

  17. A foundation monograph of Convolvulus L. (Convolvulaceae).

    Science.gov (United States)

    Wood, John R I; Williams, Bethany R M; Mitchell, Thomas C; Carine, Mark A; Harris, David J; Scotland, Robert W

    2015-01-01

    A global revision of Convolvulus L. is presented, Calystegia R.Br. being excluded on pragmatic grounds. One hundred and ninety species are recognised with the greatest diversity in the Irano-Turanian region. All recognised species are described and the majority are illustrated. Distribution details, keys to species identification and taxonomic notes are provided. Four new species, Convolvulusaustroafricanus J.R.I.Wood & R.W.Scotland, sp. nov., Convolvulusiranicus J.R.I.Wood & R.W.Scotland, sp. nov., Convolvuluspeninsularis J.R.I.Wood & R.W.Scotland, sp. nov. and Convolvulusxanthopotamicus J.R.I.Wood & R.W.Scotland, sp. nov., one new subspecies Convolvuluschinensissubsp.triangularis J.R.I.Wood & R.W.Scotland, subsp. nov., and two new varieties Convolvulusequitansvar.lindheimeri J.R.I.Wood & R.W.Scotland, var. nov., Convolvulusglomeratusvar.sachalitarum J.R.I.Wood & R.W.Scotland, var. nov. are described. Convolvulusincisodentatus J.R.I.Wood & R.W.Scotland, nom. nov., is provided as a replacement name for the illegitimate Convolvulusincisus Choisy. Several species treated as synonyms of other species in recent publications are reinstated including Convolvuluschinensis Ker-Gawl., Convolvulusspinifer M.Popov., Convolvulusrandii Rendle and Convolvulusaschersonii Engl. Ten taxa are given new status and recognised at new ranks: Convolvulusnamaquensis (Schltr. ex. A.Meeuse) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulushermanniaesubsp.erosus (Desr.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvuluscrenatifoliussubsp.montevidensis (Spreng.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulusfruticulosussubsp.glandulosus (Webb) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvuluscapituliferussubsp.foliaceus (Verdc.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulushystrixsubsp.ruspolii (Dammer ex Hallier f.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulushystrixsubsp.inermis (Chiov.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulusrottlerianussubsp.stocksii (Boiss.) J

  18. CLIMBER-2: a climate system model of intermediate complexity. Pt. 1. Model description and performance for present climate

    Energy Technology Data Exchange (ETDEWEB)

    Petoukhov, V.; Ganopolski, A.; Brovkin, V.; Claussen, M.; Eliseev, A.; Kubatzki, C.; Rahmstorf, S.

    1998-02-01

    A 2.5-dimensional climate system model of intermediate complexity CLIMBER-2 and its performance for present climate conditions are presented. The model consists of modules describing atmosphere, ocean, sea ice, land surface processes, terrestrial vegetation cover, and global carbon cycle. The modules interact (on-line) through the fluxes of momentum, energy, water and carbon. The model has a coarse spatial resolution, allowing nevertheless to capture the major features of the Earth`s geography. The model describes temporal variability of the system on seasonal and longer time scales. Due to the fact that the model does not employ any type of flux adjustment and has fast turnaround time, it can be used for study of climates significantly different from the present one and allows to perform long-term (multimillennia) simulations. The constraints for coupling the atmosphere and ocean without flux adjustment are discussed. The results of a model validation against present climate data show that the model successfully describes the seasonal variability of a large set of characteristics of the climate system, including radiative balance, temperature, precipitation, ocean circulation and cryosphere. (orig.) 62 refs.

  19. Does birth order and academic proficiency influence perfectionistic self-presentation among undergraduate engineering students? A descriptive analysis

    Directory of Open Access Journals (Sweden)

    Preeti Tabitha Louis

    2016-01-01

    Full Text Available Background: Perfectionism is a multifaceted concept. It had both advantages and disadvantages. Perfectionistic traits have been associated with leadership and very intellectual people. The present study is an attempt to understand if engineering students possess perfectionistic orientation and whether it influences self-efficacy, social connectedness, and achievement motivation. Materials and Methods: The present study adopts a random sampling design to evaluate the presence of perfectionism as a personality trait among undergraduate engineering students (N = 320. Standardized inventories such as Almost Perfect Scale-Revised were administered first to identify perfectionists and second to differentiate the adaptive from the maladaptive perfectionists. Scheduled interviews were conducted with students to obtain information regarding birth order and family functioning. Results: Findings from the study reveal that there were a significant number of maladaptive perfectionists and that they experienced higher levels of personal and societal demands leading to a negative emotional well-being in comparison to the adaptive perfectionists. We also observed that first-born children were more likely to display a perfectionistic self-presentation and from scheduled interviews, we understood that paternal influences were stronger when it came to decision-making and display of conscientiousness. Conclusion: The study draws on important implications for helping students to understand perfectionism and to respond to demands of the family and societal subsystems in a positive and an adaptive manner.

  20. I. Sleep and development: introduction to the monograph.

    Science.gov (United States)

    El-Sheikh, Mona; Sadeh, Avi

    2015-03-01

    Literature on sleep and child development is growing rapidly in exciting new directions across several disciplines and with this comes a need for guiding conceptual principles and methodological tools. In this introductory chapter, the importance of sleep for child development across multiple domains is highlighted. The aims of this monograph are presented and pertain to the need to consider and integrate theory and research across multiple disciplines and use state-of-the-art methodologies. A developmental ecological systems perspective adapted to sleep illustrates the multiple levels of influence and their importance in the study of child sleep and development. A focal aim is to provide examples of longitudinal studies linking sleep with child development, which are presented in seven chapters of this volume. © 2015 The Society for Research in Child Development, Inc.

  1. On the freshwater dinoflagellates presently included in the genus Amphidinium, with a description of Prosoaulax gen. nov

    DEFF Research Database (Denmark)

    Calado, A.; Moestrup, Øjvind

    2005-01-01

    Amphidinium is a genus of naked dinoflagellates, characterized by a small epicone and a larger hypocone. Presently about 120 species from both freshwater and marine biotopes have been described. The genus has long been known to be poly-phyletic, however, and the recent rediscovery of the type......) , and related species. Based on ultrastructural features, notably the very unusual type of eyespot, Prosoaulax is considered to be related to a recently recognized, but poorly understood group of dinoflagellates, comprising the marine species Gymnodinium simplex, G. natalense, Polarella antarctica, and some...... symbionts of marine invertebrates, G. bei and G. linucheae. It also includes the symbionts of corals (‘zooxanthellae') belonging to the genus Symbiodinium, a genus believed to contain the modern representatives of the Suessiales, an order of dinoflagellates extending back into the Mesozoic...

  2. Report on carcinogens monograph on 1-bromopropane.

    Science.gov (United States)

    2013-09-01

    The National Toxicology Program conducted a cancer evaluation on 1 bromopropane for possible listing in the Report on Carcinogens (RoC). The cancer evaluation is captured in the RoC monograph, which was peer reviewed in a public forum. The monograph consists of two components: (Part 1) the cancer evaluation, which reviews the relevant scientific information, assesses its quality, applies the RoC listing criteria to the scientific information, and provides the NTP recommendation for listing status for 1 bromopropane in the RoC, and (Part 2) the substance profile proposed for the RoC, containing the NTP's listing status recommendation, a summary of the scientific evidence considered key to reaching that decision, and data on properties, use, production, exposure, and Federal regulations and guidelines to reduce exposure to 1-bromopropane. This monograph provides an assessment of the available scientific information on 1 bromopropane, including human exposure and properties, disposition and toxicokinetics, cancer studies in experimental animals, and studies of mechanisms and other related effects, including relevant toxicological effects, genetic toxicology, and mechanisms of carcinogenicity. From this assessment, the NTP recommended that 1 bromopropane be listed as reasonably anticipated to be a human carcinogen in the RoC based on sufficient evidence from studies in experimental animals, which found inhalation exposure to 1-bromopropane caused skin tumors in male rats, large intestine tumors in female and male rats, and lung tumors in female mice. Also noted was that 1 bromopropane, either directly or via reactive metabolites, caused molecular alterations that typically are associated with carcinogenesis, including genotoxicity, oxidative stress, and glutathione depletion. These alterations, observed in mainly in vitro and toxicity studies in rodents, are relevant to possible mechanisms of human carcinogenicity and support the relevance of the cancer studies in

  3. Report on carcinogens monograph on cumene.

    Science.gov (United States)

    2013-09-01

    The National Toxicology Program conducted a cancer evaluation on cumene for possible listing in the Report on Carcinogens (RoC). The cancer evaluation is captured in the RoC monograph, which was peer reviewed in a public forum. The monograph consists of two components: (Part 1) the cancer evaluation, which reviews the relevant scientific information, assesses its quality, applies the RoC listing criteria to the scientific information, and provides the NTP recommendation for listing status for cumene in the RoC, and (Part 2) the substance profile proposed for the RoC, containing the NTP's listing status recommendation, a summary of the scientific evidence considered key to reaching that decision, and data on properties, use, production, exposure, and Federal regulations and guidelines to reduce exposure to cumene. This monograph provides an assessment of the available scientific information on cumene, including human exposure and properties, disposition and toxicokinetics, cancer studies in experimental animals, and studies of mechanisms and other related effects, including relevant toxicological effects, genetic toxicology, and mechanisms of carcinogenicity. From this assessment, the NTP recommended that cumene be listed as reasonably anticipated to be a human carcinogen in the RoC based on sufficient evidence from studies in experimental animals, which found that cumene exposure caused lung tumors in male and female mice and liver tumors in female mice. Several proposed mechanisms of carcinogenesis support the relevance to humans of the lung and liver tumors observed in experimental animals. Specifically, there is evidence that humans and experimental animals metabolize cumene through similar metabolic pathways. In addition, mutations of the K-ras oncogene and p53 tumor-suppressor gene observed in cumene-induced lung tumors in mice, along with altered expression of many other genes, resemble molecular alterations found in human lung and other cancers.

  4. Creative Drama as a Resource, K-12. Language Arts Monograph.

    Science.gov (United States)

    Sharpham, John R.

    Defining creative drama as a teaching process that uses the inherent ability of each person to explore ideas, behavior patterns, and human relationships, this monograph is designed to help teachers create a working environment within which this process can be most productive. Various sections of the monograph provide information about how creative…

  5. [Leon Daraszkiewicz and his monograph on hebephrenia].

    Science.gov (United States)

    Marcinowski, Filip

    2012-01-01

    Leon Daraszkiewicz (1866-1931) was a Polish psychiatrist, a pupil and co-worker of E. Kraepelin and V. Tsiz on the University of Dorpat (now Tartu, Estonia), the author of highly regarded monograph on hebephrenia (1891). In his work on the basis of over 20 case histories, he described a natural history of hebephrenia and his own views on its aetiology and prognosis. Hebephrenia as described by Daraszkiewicz, served as a clinical model for the Kraepelinian concept of dementia praecox. In the article, the life and career of Daraszkiewicz is covered, with particular emphasis on the role of his doctoral dissertation on hebephrenia in the history of the concept of schizophrenia.

  6. Drug Monographs: Olaratumab and Rucaparib.

    Science.gov (United States)

    Solimando, Dominic A; Waddell, J Aubrey

    2017-04-01

    The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast.net; or J. Aubrey Waddell, Professor, University of Tennessee College of Pharmacy; Oncology Pharmacist, Pharmacy Department, Blount Memorial Hospital, 907 E. Lamar Alexander Parkway, Maryville, TN 37804, e-mail: waddfour@charter.net. The information presented in this review is based on published data and clinical expertise and includes information not included in the product labeling. Incorporation of such published data provides a more robust assessment of the drugs and assists pharmacists in evaluation of orders for off-label use of these agents.

  7. A foundation monograph of Convolvulus L. (Convolvulaceae)

    Science.gov (United States)

    Wood, John R.I.; Williams, Bethany R.M.; Mitchell, Thomas C.; Carine, Mark A.; Harris, David J.; Scotland, Robert W.

    2015-01-01

    Abstract A global revision of Convolvulus L. is presented, Calystegia R.Br. being excluded on pragmatic grounds. One hundred and ninety species are recognised with the greatest diversity in the Irano-Turanian region. All recognised species are described and the majority are illustrated. Distribution details, keys to species identification and taxonomic notes are provided. Four new species, Convolvulus austroafricanus J.R.I.Wood & R.W.Scotland, sp. nov., Convolvulus iranicus J.R.I.Wood & R.W.Scotland, sp. nov., Convolvulus peninsularis J.R.I.Wood & R.W.Scotland, sp. nov. and Convolvulus xanthopotamicus J.R.I.Wood & R.W.Scotland, sp. nov., one new subspecies Convolvulus chinensis subsp. triangularis J.R.I.Wood & R.W.Scotland, subsp. nov., and two new varieties Convolvulus equitans var. lindheimeri J.R.I.Wood & R.W.Scotland, var. nov., Convolvulus glomeratus var. sachalitarum J.R.I.Wood & R.W.Scotland, var. nov. are described. Convolvulus incisodentatus J.R.I.Wood & R.W.Scotland, nom. nov., is provided as a replacement name for the illegitimate Convolvulus incisus Choisy. Several species treated as synonyms of other species in recent publications are reinstated including Convolvulus chinensis Ker-Gawl., Convolvulus spinifer M.Popov., Convolvulus randii Rendle and Convolvulus aschersonii Engl. Ten taxa are given new status and recognised at new ranks: Convolvulus namaquensis (Schltr. ex. A.Meeuse) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus hermanniae subsp. erosus (Desr.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus crenatifolius subsp. montevidensis (Spreng.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus fruticulosus subsp. glandulosus (Webb) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus capituliferus subsp. foliaceus (Verdc.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus hystrix subsp. ruspolii (Dammer ex Hallier f.) J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus hystrix subsp. inermis (Chiov.) J.R.I.Wood & R.W.Scotland, stat. nov

  8. 77 FR 48995 - Draft National Toxicology Program (NTP) Monograph on Developmental Effects and Pregnancy Outcomes...

    Science.gov (United States)

    2012-08-15

    ... HUMAN SERVICES National Institutes of Health Draft National Toxicology Program (NTP) Monograph on... of the draft monograph. Topic: Peer review of the draft NTP Monograph on Developmental Effects and... scheduled for oral public comment. The NTP also invites written comments on the draft monograph, submission...

  9. A Review of the Multi-Authored Monograph “The Medical (Clinical Psychology Diagnosis: Current State and Prospects”

    Directory of Open Access Journals (Sweden)

    Vachkov I.V.

    2017-06-01

    Full Text Available The monograph presents a number of articles written by leading domestic clinical psychologists on various issues connected with psychological diagnosis. The multi-authored monograph was written for the international research-to-practice conference “The medical (clinical psychology diagnosis: tradition and prospects”. The conference took place in Moscow on November 29-30, 2016. The book consists of the following sections: "Research methodology in clinical psychology", “The development of endogenous mental pathology diagnosis current trends”, “The development of clinical psychology diagnostics current trends: age aspects”, “The main problems of clinical-psychological prevention and rehabilitation”. The materials of the monograph may be interesting and useful for scientists, psychology lecturers, students and post-graduate students, as well as for specialists working in the field of public health, education and social support for the population.

  10. Synchronous Low-grade Appendiceal Mucinous Neoplasm and Primary Peritoneal Low-grade Serous Carcinoma: A First Description of These 2 Neoplasms Presenting Together as Suspected Peritoneal Carcinomatosis.

    Science.gov (United States)

    Sekulic, Miroslav; Pichler Sekulic, Simona; Movahedi-Lankarani, Saeid

    2016-09-28

    Low-grade appendiceal mucinous neoplasm is a neoplasm typically of appendiceal origin, which is characterized by diffuse peritoneal involvement by pools of mucin with mucinous epithelium lacking high-grade cytologic atypia, and clinically presents as suspected peritoneal carcinomatosis. A similar clinical presentation can sometimes be seen with disseminated low-grade serous carcinomas of the peritoneum, fallopian tubes, or ovaries; however, this neoplasm is histologically characterized by tubal-type epithelium and invasive or confluent growth. In this case report, we describe a patient presenting with a clinical examination and radiologic features suggestive of peritoneal carcinomatosis and a prominent pelvic mass; however, after pathologic review, the patient was proven to have peritoneal involvement by both low-grade appendiceal mucinous neoplasm of appendiceal origin and a low-grade peritoneal primary serous carcinoma. In short, we present the first description of low-grade appendiceal mucinous neoplasm and serous carcinoma of the peritoneum presenting synchronously, providing morphologic characterization and immunohistochemical studies supporting the diagnosis, and illustrating a rare instance in which 2 neoplastic processes are underlying clinically suspected peritoneal carcinomatosis.

  11. A trajectory description of quantum processes. II. Applications. A Bohmian perspective

    Energy Technology Data Exchange (ETDEWEB)

    Sanz, Angel S.; Miret-Artes, Salvador [CSIC, Madrid (Spain). Inst. de Fisica Fundamental (IFF-CSIC)

    2014-07-01

    Presents a thorough introduction to, and treatment of, trajectory-based quantum-mechanical calculations. Useful for a wide range of scattering problems. Presents the applications of the trajectory description of basic quantum processes. Trajectory-based formalisms are an intuitively appealing way of describing quantum processes because they allow the use of ''classical'' concepts. Beginning as an introductory level suitable for students, this two-volume monograph presents (1) the fundamentals and (2) the applications of the trajectory description of basic quantum processes. This second volume is focussed on simple and basic applications of quantum processes such as interference and diffraction of wave packets, tunneling, diffusion and bound-state and scattering problems. The corresponding analysis is carried out within the Bohmian framework. By stressing its interpretational aspects, the book leads the reader to an alternative and complementary way to better understand the underlying quantum dynamics.

  12. HUMAN IN SPEECH DIMENSION REVIEW OF THE MONOGRAPH: KARASIK V. I. YAZYKOVOYE PROYAVLENIYE LICHNOSTI: MONOGRAFIYA [LINGUISTIC MANIFESTATION OF PERSONALITY] / KARASIK V.I.; VOLGOGRADSKIY GOS. SOTSIALNO-PEDAGOGICHESKIY UN-T, NAUCHNO-ISSLEDOVATELSKAYA LABORATORIYA «AKSIOLOGICHESKAYA LINGVISTIKA». VOLGOGRAD: PARADIGMA, 2014. 449 P

    Directory of Open Access Journals (Sweden)

    VASILEVA V.V.

    2015-01-01

    Full Text Available The review presents to the reader a monographic study by V. Karasik, performed in the mainstream of anthropological linguistics. The peer-reviewed monograph suggests a model for study of human in its linguistic manifestation: as elements of this model serve the "axiological situation, conceptualization of the value and discourse as the embodiment of values". The author of the monograph suggests an issue of the discursive modes of an individual for discussion and considers the typological characteristics of the discourses. Particular attention is given to the typological characteristics of media discourse. The monograph also presents the poetic dimension of personality, which considers poetic reflection, poetic impact, and poetic technique.

  13. HUMAN IN SPEECH DIMENSION REVIEW OF THE MONOGRAPH: KARASIK V. I. YAZYKOVOYE PROYAVLENIYE LICHNOSTI: MONOGRAFIYA [LINGUISTIC MANIFESTATION OF PERSONALITY] / KARASIK V.I.; VOLGOGRADSKIY GOS. SOTSIALNO-PEDAGOGICHESKIY UN-T, NAUCHNO-ISSLEDOVATELSKAYA LABORATORIYA «AKSIOLOGICHESKAYA LINGVISTIKA». VOLGOGRAD: PARADIGMA, 2014. 449 P

    Directory of Open Access Journals (Sweden)

    VASILEVA V.V.

    2015-12-01

    Full Text Available The review presents to the reader a monographic study by V. Karasik, performed in the mainstream of anthropological linguistics. The peer-reviewed monograph suggests a model for study of human in its linguistic manifestation: as elements of this model serve the "axiological situation, conceptualization of the value and discourse as the embodiment of values". The author of the monograph suggests an issue of the discursive modes of an individual for discussion and considers the typological characteristics of the discourses. Particular attention is given to the typological characteristics of media discourse. The monograph also presents the poetic dimension of personality, which considers poetic reflection, poetic impact, and poetic technique.

  14. A Monograph of Conostegia (Melastomataceae, Miconieae).

    Science.gov (United States)

    Kriebel, Ricardo

    2016-01-01

    A recent molecular phylogenetic analysis identified a clade containing all species of Conostegia, but that also included species of Clidemia and Miconia nested inside. A taxonomic revision of a more broadly circumscribed Conostegia is presented here. In total, 77 species of Conostegia are recognized. One species from Ecuador, Conostegia ortizae is described as new. Twenty-nine new combinations are proposed for the species of Clidemia and Miconia that fall inside Conostegia. Two new names are proposed for the two species for which the epithet was previously occupied in Conostegia. An infrageneric classification of Conostegia is proposed recognizing three sections based on the results of the molecular phylogeny. This taxonomic revision includes ample documentation of the anatomy and morphology of most species in the genus, taxonomic descriptions, a dichotomous key, and distribution maps for all species.

  15. Social Development: Self Help Skills. A Performance-Based Early Childhood-Special Education Teacher Preparation Program. Monograph 13.

    Science.gov (United States)

    Mann, Lynne

    This monograph presents the self-help skills module of the social development curriculum portion of the Early Childhood-Special Education Teacher Preparation Program. Included are: (1) an ontogeny of self-help skills (feeding, dressing, toileting, and grooming) in young children; (2) a brief discussion of the relevance of self-help skills to the…

  16. Banach spaces and descriptive set theory selected topics

    CERN Document Server

    Dodos, Pandelis

    2010-01-01

    This volume deals with problems in the structure theory of separable infinite-dimensional Banach spaces, with a central focus on universality problems. This topic goes back to the beginnings of the field and appears in Banach's classical monograph. The novelty of the approach lies in the fact that the answers to a number of basic questions are based on techniques from Descriptive Set Theory. Although the book is oriented on proofs of several structural theorems, in the main text readers will also find a detailed exposition of numerous “intermediate” results which are interesting in their own right and have proven to be useful in other areas of Functional Analysis. Moreover, several well-known results in the geometry of Banach spaces are presented from a modern perspective.

  17. MSM 2010 Theme Monograph Psychopharmacology Today

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2010-01-01

    Full Text Available This theme monograph is called Psychopharmacology Today. It has some notable contributions on issues in psychopharmacology.MSM 2010 is dedicated to the fond memory of Dr V.N. Bagadia, who headed our Hon International Editorial Advisory Board. See Dedication, " Dr Bagadia, Sir, is no more"(p3.Thomas L. Schwartz, M.D. Associate Professor of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA writes an editorial on, "Psychopharmacology today: where are we and where do we go from here?"(p6.Ajai R. Singh, MD. Editor, Mens Sana Monographs, writes the second editorial on, "Modern medicine: towards prevention, cure, well-being and longevity"(p17.Sannidhya Varma, Himanshu Sareen and J.K. Trivedi from CSM Medical University, Lucknow, India, write on, "The Geriatric Population and Psychiatric Medication"(p30.Amresh Shrivastava from The University of Western Ontario, Department of Psychiatry and Megan E. Johnston from University of Toronto, Department of Psychology, write on, "Weight Gain in Psychiatric Treatment: Risks, Implications, and Strategies for Prevention and Management"(p53.Avinash De Sousa, M.D. Consultant Psychiatrist& Psychotherapist, Mumbai, writes on, "The Pharmacotherapy of Alcohol Dependence: A State of the Art Review"(p69. Late B. M. Tripathi, M.D. Professor, Department of Psychiatry and National Drug Dependence and Treatment Center, All India Institute of Medical Sciences, and Pradipta Majumder, MBBS, Resident, Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, write on, "Lactating Mother and Psychotropic Drugs"(p83.K.S. Latha PhD. Associate Professor, Department of Psychiatry, KMC Hospital, Manipal University, writes on, "The Noncompliant Patient in Psychiatry: The Case For and Against Covert/Surreptitious Medication"(p96. Neha Khetrapal, [M.A. Cognitive Science], Centre of Excellence "Cognitive Interaction Technology" (CITEC And Faculty of Psychology& Sport Sciences, University of Bielefeld, Germany

  18. [The classics of Italian nephrology: the monograph "La nefropatia diabetica" (Diabetic nephropathy) by Luigi Scapellato (1918-1998)].

    Science.gov (United States)

    Fogazzi, G B

    2007-01-01

    This monograph, published in 1953, describes the findings observed by the author in a cohort of patients affected by diabetes mellitus and renal disease. From a pathological standpoint, the typical renal lesion is represented by ''nodular intercapillary glomerulosclerosis'', which is present in 8 out of 20 patients at postmortem. Marked proteinuria and edema are the most typical clinical features. Urinary sediment examination is the only test allowing to differentiate diabetic nephropathy from other glomerular diseases. In the initial phases, the glomerular filtration rate is increased rather than reduced. The evolution is almost invariably towards end-stage renal disease, and a hypoglucidic diet and insulin are the only therapeutic modalities available. Today this work shows us, on the one hand, how many uncertainties still existed about diabetic nephropathy 17 years after its first description by Kimmelstiel and Wilson in 1936. On the other hand, it shows how much relevant and still valid information was already known at the time. Luigi Scapellato, who is almost completely forgotten today, began his career at the Clinica Medica of the University of Rome under the guidance of Cesare Frugoni (1881-1978). In 1959, he moved to Syracuse (Sicily) to work as director of the internal medicine unit of the ''Umberto I'' Hospital. In April 1957 he was among the 13 founders of the Italian Society of Nephrology.

  19. Elements for a of Rural Research Methodology. Sociological Monographs and the Rural Sociological Atlas

    Directory of Open Access Journals (Sweden)

    VERONICA DUMITRAŞCU

    2009-04-01

    Full Text Available This article attempts to provide an "X-ray image" of rural life through the inventory of certain research methods and techniques used in the study of Romanian rural communities. Sociological monographs, including the sociological rural atlas,were the epitome of Gustian sociology. The investigation of rural life focusing on certain key aspects - economic, political, and religious - simultaneously, can provide a more comprehensive perspective on the Romanian village than would be possible by considering each of these elements on its own. Hence, the monograph brings unity to past and present realities. The dynamic character of sociology, on which the Sociological School of Bucharest focused, can be applied nowadays as well. The sociologist is called forth now more than ever in order to interfere with social life. In this case, the methodological tool, that is the monograph, is very useful. Through the Social Atlas, the problems of rural communities can be anticipated and diagnosed and, as such, certain serious problems which take place in a social dimension can be averted. Hence, the Social Atlas project is very useful for research on rural life, as the maps capture the progress of social change.

  20. Non-European traditional herbal medicines in Europe: a community herbal monograph perspective.

    Science.gov (United States)

    Qu, Liping; Zou, Wenjun; Zhou, Zhenxiang; Zhang, Tingmo; Greef, JanVander; Wang, Mei

    2014-10-28

    medicinal use period in the EU and evidence of absence of health risk as required by Article 16a (1) (d), and Article 16a (1) (e). Under the current EU legislation, the requirement to demonstrate 15-year minimum medicinal use in the EU is a major obstacle to the registration of non-European traditional herbal medicinal products. Access to scientific data to support the product safety profile may be a possible solution to overcome the hurdle presented by the 15-year minimum medicinal use period. Furthermore, the Community herbal monographs play an important role in the registration process. Therefore, making full use of existing Community herbal monographs, and promoting scientific research and subsequent development of additional monographs for herbal substances and preparations, and combinations thereof from non-European traditions would be of benefit to herbal medicinal product registration from non-European traditions. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  1. Could EU herbal monographs contribute to Malta's treatment armamentarium?

    Science.gov (United States)

    Micallef, B; Attard, E; Serracino-Inglott, A; Borg, J J

    2015-03-15

    Ten years have passed since Directive 2004/24/EC regulating herbal medicinal products across the EU were published. The directive created the Committee on Herbal Medicinal Products within the European Medicines Agency whose remit includes the creation and publishing of official EU monographs on herbal medicinal products. These monographs include the official uses of the products and their evidence for efficacy and safety. To this effect, we are interested in analysing the potential impact herbal product EU monographs could have on the therapeutic treatment options available for prescribers in Malta. Therefore our aim was two-fold. First, to rationalise the spread of indications of the herbal substances listed in the community herbal monograph inventory and subsequently determine if these herbal substances could potentially contribute to the treatment options available in our local scenario (Malta). 128 EU monographs were analysed resulting in a total of 230 indications which subsequently codified into 42 unique ATC codes. The Malta Medicines List contains 1456 unique ATC codes. Comparative analysis of the Malta Medicines List revealed that the 21 therapeutic areas had 4 or less pharmaceutically used substances (5th level ATC codes) registered and therefore in our opinion are areas with limited therapeutic choice. The following 4 therapeutic areas, A05 bile and liver therapy, A13 tonics, A15 appetite stimulants and D03 preparations for treatment of wounds and ulcers, could potentially benefit from the registration of herbal medicinal products according to the EU herbal monographs. If such registration is effected the aforementioned areas would no longer be considered limited because more than 4 therapeutic choices would be available to prescribers. This study is the first study across the EU to analyse the potential impact of published EU herbal monographs on therapeutic coverage in an EU member state and confirms the notion that herbal products could potentially

  2. NTP-CERHR monograph on Soy Infant Formula.

    Science.gov (United States)

    2010-09-01

    Soy infant formula contains soy protein isolates and is fed to infants as a supplement to or replacement for human milk or cow milk. Soy protein isolates contains estrogenic isoflavones ("phytoestrogens") that occur naturally in some legumes, especially soybeans. Phytoestrogens are non-steroidal, estrogenic compounds. In plants, nearly all phytoestrogens are bound to sugar molecules and these phytoestrogen-sugar complexes are not generally considered hormonally active. Phytoestrogens are found in many food products in addition to soy infant formula, especially soy-based foods such as tofu, soy milk, and in some over-the-counter dietary supplements. Soy infant formula was selected for evaluation by the National Toxicology Program (NTP) because of the: (1)availability of large number of developmental toxicity studies in laboratory animals exposed to the isoflavones found in soy infant formula (namely, genistein) or other soy products, as well as a number of studies on human infants fed soy infant formula, (2)the availability of information on exposures in infants fed soy infant formula, and (3)public concern for effects on infant or child development. The NTP evaluation was conducted through its Center for the Evaluation of Risks to Human Reproduction (CERHR) and completed in September 2010. The results of this soy infant formula evaluation are published in an NTP Monograph. This document contains the NTP Brief on Soy Infant Formula, which presents NTP's opinion on the potential for exposure to soy infant formula to cause adverse developmental effects in humans. The NTP Monograph also contains an expert panel report prepared to assist the NTP in reaching conclusions on soy infant formula. The NTP concluded there is minimal concern for adverse effects on development in infants who consume soy infant formula. This level of concern represents a "2" on the five-level scale of concern used by the NTP that ranges from negligible concern ("1") to serious concern ("5"). This

  3. Monograph of the genus Phylacium (Leguminosae)

    NARCIS (Netherlands)

    Bresser, Mirjam

    1978-01-01

    In the genus Phylacium 2 species are recognized. Special attention is paid to the morphology of the inflorescence; full descriptions are given with plates and a map, showing the distribution of both species.

  4. Attitudes and beliefs of Australian adults on reality television cooking programmes and celebrity chefs. Is there cause for concern? Descriptive analysis presented from a consumer survey.

    Science.gov (United States)

    Villani, A M; Egan, T; Keogh, J B; Clifton, P M

    2015-08-01

    There is evidence suggesting that the nutritional content of recipes promoted by celebrity chefs or television cooking programmes contradict healthy eating guidelines. This study aims to investigate people's attitudes and beliefs about popular television cooking programmes and celebrity chefs. Males and females who watch television cooking programmes were recruited to participate in a self-administered online questionnaire (22-items) which included multiple-choice and rank order questions. A total of n = 207 participants undertook the questionnaire with fully completed questionnaires available for n = 150 participants (Males, n = 22; Females, n = 128; aged 38.4 ± 14 years). The majority of respondents watch ≤30 minutes of television cooking programming per day (total responses, n = 153/207; 74%) with almost three-quarters (total responses, n = 130/175; 74%) having attempted a recipe. New cooking ideas (total responses, n = 81/175; 46%) and entertainment (total responses, n = 64/175; 36.5%) were the two main reasons participants gave for watching these programmes. Significantly more respondents believed recipes use excessive amounts of unhealthy fat, sugar or salt (unhealthy: 24%; healthy: 7%; P people watch these programmes. However results generated from the present study are descriptive and subjective and further investigation into the impact of television cooking programmes and celebrity chefs on behavioural change requires attention. Further investigation including a systematic investigation into the dietary quality of recipes promoted by celebrity chefs against national healthy eating benchmarks is also warranted. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. 75 FR 30838 - Drometrizole Trisiloxane Eligibility for Potential Inclusion in Sunscreen Monograph; Over-the...

    Science.gov (United States)

    2010-06-02

    ... Eligibility for Potential Inclusion in Sunscreen Monograph; Over-the-Counter Sunscreen Drug Products for Human... monograph. We reviewed a time and extent application (TEA) for drometrizole trisiloxane and determined that it is eligible to be considered for inclusion in our OTC drug monograph system. We will evaluate the...

  6. Regulation and Education: Strategies for Solving the Bottle Feeding Problem. Monograph Series No. 4.

    Science.gov (United States)

    Greiner, Ted

    This book is the fourth monograph in the Cornell International Monograph Series, the second in the series to deal with the question of breast versus bottle feeding. The introduction to the monograph discusses the shift from breast to bottle feeding in both industrialized and developing nations. Some of the reasons for, and consequences of, the…

  7. 78 FR 4419 - Draft Report on Carcinogens Monographs for 1-Bromopropane and Cumene; Availability of Documents...

    Science.gov (United States)

    2013-01-22

    ... HUMAN SERVICES National Institutes of Health Draft Report on Carcinogens Monographs for 1-Bromopropane... meeting of the Draft Report on Carcinogens (RoC) Monographs for 1-Bromopropane and Cumene. These documents....m. until adjournment, approximately 2:00 p.m. EDT. Document Availability: Draft monographs will...

  8. The monographic sociology from the perspective of American critical ethnography

    Directory of Open Access Journals (Sweden)

    Șerban Văetiși

    2013-11-01

    Full Text Available The paper attempts to reconsider some theoretical and methodological principles practiced by the Bucharest School of Sociology by invoking some concepts put forward by the so called Critical Ethnography. It considers three major ideas of the Monographic Sociology, that can be also found as theoretical assumptions of the postmodern critical ethnographic theory, in an interesting parallel that can be, thus, reconstructed and further suggested as useful paradigm within current approaches in social sciences and policies: interdisciplinarity, activism and criticism. The paper concludes on the contribution that the Monographic School may have to the current social theory, research and policy developed today in Romania.

  9. A Monograph on Spanish Palaeozoic Crinoidea

    NARCIS (Netherlands)

    Breimer, A.

    1962-01-01

    It has been the aim of this study to give a comprehensive description of the important crinoid fauna's of the Palaeozoic core of North Western Spain (provinces Palencia, León and Asturias). This was opportune since fine collections of crinoids had been made during the years 1955—1960 by students of

  10. A monograph of the Genus Aristida

    NARCIS (Netherlands)

    Henrard, J.Th.

    1929-01-01

    In a preliminary work: „A critical Revision of the genus Aristida”, I have given a review of all the hitherto described species of this genus with the citation of the literature, the exact copies of the authentic descriptions and the figures of the spikelet-characters, taken from the type specimens

  11. A monograph of the Genus Aristida

    NARCIS (Netherlands)

    Henrard, J.Th.

    1929-01-01

    In a preliminary work: „A critical Revision of the genus Aristida”, I have given a review of all the hitherto described species of this genus with the citation of the literature, the exact copies of the authentic descriptions and the figures of the spikelet-characters, taken from the type specimens

  12. A monograph of the Vochysiaceae ̶ I. Salvertia and Vochysia

    NARCIS (Netherlands)

    Stafleu, F.A.

    1948-01-01

    This publication is intended to be the first part of a taxonomic monograph of the family Vochysiaceae and deals with the genera Salvertia and Vochysia. Since Warming’s excellent treatise of the Brazilian species of this family in the Flora Brasiliensis (Vol. XIII, II,1875) a large number of new spec

  13. The Chemistry of Food Dyes. Palette of Color Monograph Series.

    Science.gov (United States)

    Epp, Dianne N.

    Dyes aren't just for fabrics--colorants have been added to food for centuries to enhance its appearance. This monograph and teaching guide investigates both the compounds that give foods their natural color and synthetic colorants currently approved for use in foods. Problem-solving inquiry based activities involve high school level students in…

  14. The Chemistry of Food Dyes. Palette of Color Monograph Series.

    Science.gov (United States)

    Epp, Dianne N.

    Dyes aren't just for fabrics--colorants have been added to food for centuries to enhance its appearance. This monograph and teaching guide investigates both the compounds that give foods their natural color and synthetic colorants currently approved for use in foods. Problem-solving inquiry based activities involve high school level students in…

  15. Safety in Team Sports. Sports Safety Series, Monograph No. 3.

    Science.gov (United States)

    Borozne, Joseph, Ed.; And Others

    This monograph examines methods of promoting safe practices in the conduct of selected team sports with the aim of reducing and eliminating the occurrance of injuries. The team sports discussed are baseball and softball, basketball, field hockey, tackle football, touch and flag football, ice hockey, lacrosse, and soccer. (MJB)

  16. Use of High Throughput Screening Data in IARC Monograph ...

    Science.gov (United States)

    Purpose: Evaluation of carcinogenic mechanisms serves a critical role in IARC monograph evaluations, and can lead to “upgrade” or “downgrade” of the carcinogenicity conclusions based on human and animal evidence alone. Three recent IARC monograph Working Groups (110, 112, and 113) pioneered analysis of high throughput in vitro screening data from the U.S. Environmental Protection Agency’s ToxCast program in evaluations of carcinogenic mechanisms. Methods: For monograph 110, ToxCast assay data across multiple nuclear receptors were used to test the hypothesis that PFOA acts exclusively through the PPAR family of receptors, with activity profiles compared to several prototypical nuclear receptor-activating compounds. For monographs 112 and 113, ToxCast assays were systematically evaluated and used as an additional data stream in the overall evaluation of the mechanistic evidence. Specifically, ToxCast assays were mapped to 10 “key characteristics of carcinogens” recently identified by an IARC expert group, and chemicals’ bioactivity profiles were evaluated both in absolute terms (number of relevant assays positive for bioactivity) and relative terms (ranking with respect to other compounds evaluated by IARC, using the ToxPi methodology). Results: PFOA activates multiple nuclear receptors in addition to the PPAR family in the ToxCast assays. ToxCast assays offered substantial coverage for 5 of the 10 “key characteristics,” with the greates

  17. A monograph of the Vochysiaceae ̶ I. Salvertia and Vochysia

    NARCIS (Netherlands)

    Stafleu, F.A.

    1948-01-01

    This publication is intended to be the first part of a taxonomic monograph of the family Vochysiaceae and deals with the genera Salvertia and Vochysia. Since Warming’s excellent treatise of the Brazilian species of this family in the Flora Brasiliensis (Vol. XIII, II,1875) a large number of new

  18. Sex Bias in ASAT? ACER Research Monograph No. 24.

    Science.gov (United States)

    Adams, Raymond J.

    The Australian Scholastic Test (ASAT) was first used as a moderating device in the Australian Capitol Territory in 1977. Differences have been observed in the average performance of males and females on the test. The study reported in this monograph investigated the nature and origin of the score differences recorded for ASAT The research focused…

  19. Assessing Creativity: A Guide for Educators. Research Monograph Series.

    Science.gov (United States)

    Treffinger, Donald J.; Young, Grover C.; Selby, Edwin C.; Shepardson, Cindy

    This monograph deals specifically with the challenge of recognizing or assessing creativity. Following an introductory chapter, chapter 2 focuses on definitions and characteristics of creativity to help clarify the nature and meaning of creativity and creative thinking, and to consider the implications of those definitions for assessment. The…

  20. The significance of field work in monographic studies

    Science.gov (United States)

    The focus of this paper is to document the clear and obvious advantages of field work for monographic studies. These advantages include: 1) ability to understand published distributions better and greatly expand these data, 2) access to taxonomic data obscured on herbarium sheets (as colors, odors, ...

  1. State Defense Force Monograph Series. Winter 2006, Medical Support Teams

    Science.gov (United States)

    2006-01-01

    assets for mobile support teams, labs, immunizations, latent TB screening, and post-deployment assessments.” (COL Eric Allely, Maryland State Surgeon...infarctions ! Diabetes ! Mental health problems ! Hypertension ! Diarrhea ! Heat injuries 30 State Defense Force Monograph Series, Summer 2006...for dysentery and vomiting ! Viral meningitis ! Injuries due to off-site fighting ! Tuberculosis ! HIV ! Special medical needs. See Figures 3

  2. Preface to the first monograph: The Fourth Psychiatric Revolution

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2004-05-01

    the one hand, and cautious forays in the neurosciences, adoption and genetic studies on the other ( from where, hopefully, significant leads in understanding the aetiology of major psychiatric disorders must arise. Diagnostic refinement is a necessary step in this direction, as is use of sophisticated technology to aid the process.And yet, we know that psychiatry, its practitioners, and its patients, do not function in a vacuum. They interact with, and are influenced by, a wide range of complex, interlinked, social and interpersonal forces.These forces are often generated by people not directly connected with the medical speciality of psychiatry. They are the policy-planners, governments, political leaders, activists, social thinkers, NGOs, mass media, enlightened public opinion etc. They have marked influence on social thought and action, policy, funding and research. They influence people and societies often in more significant ways than the medical speciality of psychiatry considers healthy for society.We may continue to function in a vacuum and wait for wisdom to dawn. Or, we may establish a dialogue with them and work for wisdom for happen.The second option seems the more productive one.No doubt, there are some psychiatrists comfortable with the biological label. There are others comfortable with the social one. Both these are needed, for they help to further robust enquiry in their respective fields. But what we also probably need is an integration, a synthesis of the mass of evidence that these two fields have produced. The inevitable conclusions drawn at our present state of knowledge based on such integration will give rise to pointers for further research as well as guidelines for policy-planners. Moreover, it will result in an awakened public opinion empowered with knowledge and evidence, its actions enlightened, and unlikely to be swayed or manipulated by unscrupulous forces.The Mens Sana Monographs are meant to further attempts at such a Fourth

  3. Prioritizing Chemicals for Risk Assessment Using Chemoinformatics: Examples from the IARC Monographs on Pesticides.

    Science.gov (United States)

    Guha, Neela; Guyton, Kathryn Z; Loomis, Dana; Barupal, Dinesh Kumar

    2016-12-01

    Identifying cancer hazards is the first step towards cancer prevention. The International Agency for Research on Cancer (IARC) Monographs Programme, which has evaluated nearly 1,000 agents for their carcinogenic potential since 1971, typically selects agents for hazard identification on the basis of public nominations, expert advice, published data on carcinogenicity, and public health importance. Here, we present a novel and complementary strategy for identifying agents for hazard evaluation using chemoinformatics, database integration, and automated text mining. To inform selection among a broad range of pesticides nominated for evaluation, we identified and screened nearly 6,000 relevant chemical structures, after which we systematically compiled information on 980 pesticides, creating network maps that allowed cluster visualization by chemical similarity, pesticide class, and publicly available information concerning cancer epidemiology, cancer bioassays, and carcinogenic mechanisms. For the IARC Monograph meetings that took place in March and June 2015, this approach supported high-priority evaluation of glyphosate, malathion, parathion, tetrachlorvinphos, diazinon, p,p'-dichlorodiphenyltrichloroethane (DDT), lindane, and 2,4-dichlorophenoxyacetic acid (2,4-D). This systematic approach, accounting for chemical similarity and overlaying multiple data sources, can be used by risk assessors as well as by researchers to systematize, inform, and increase efficiency in selecting and prioritizing agents for hazard identification, risk assessment, regulation, or further investigation. This approach could be extended to an array of outcomes and agents, including occupational carcinogens, drugs, and foods. Citation: Guha N, Guyton KZ, Loomis D, Barupal DK. 2016. Prioritizing chemicals for risk assessment using chemoinformatics: examples from the IARC Monographs on Pesticides. Environ Health Perspect 124:1823-1829; http://dx.doi.org/10.1289/EHP186.

  4. Prioritizing Chemicals for Risk Assessment Using Chemoinformatics: Examples from the IARC Monographs on Pesticides

    Science.gov (United States)

    Guha, Neela; Guyton, Kathryn Z.; Loomis, Dana; Barupal, Dinesh Kumar

    2016-01-01

    Background: Identifying cancer hazards is the first step towards cancer prevention. The International Agency for Research on Cancer (IARC) Monographs Programme, which has evaluated nearly 1,000 agents for their carcinogenic potential since 1971, typically selects agents for hazard identification on the basis of public nominations, expert advice, published data on carcinogenicity, and public health importance. Objectives: Here, we present a novel and complementary strategy for identifying agents for hazard evaluation using chemoinformatics, database integration, and automated text mining. Discussion: To inform selection among a broad range of pesticides nominated for evaluation, we identified and screened nearly 6,000 relevant chemical structures, after which we systematically compiled information on 980 pesticides, creating network maps that allowed cluster visualization by chemical similarity, pesticide class, and publicly available information concerning cancer epidemiology, cancer bioassays, and carcinogenic mechanisms. For the IARC Monograph meetings that took place in March and June 2015, this approach supported high-priority evaluation of glyphosate, malathion, parathion, tetrachlorvinphos, diazinon, p,p′-dichlorodiphenyltrichloroethane (DDT), lindane, and 2,4-dichlorophenoxyacetic acid (2,4-D). Conclusions: This systematic approach, accounting for chemical similarity and overlaying multiple data sources, can be used by risk assessors as well as by researchers to systematize, inform, and increase efficiency in selecting and prioritizing agents for hazard identification, risk assessment, regulation, or further investigation. This approach could be extended to an array of outcomes and agents, including occupational carcinogens, drugs, and foods. Citation: Guha N, Guyton KZ, Loomis D, Barupal DK. 2016. Prioritizing chemicals for risk assessment using chemoinformatics: examples from the IARC Monographs on Pesticides. Environ Health Perspect 124:1823–1829;

  5. Monograph use at an academic health sciences library: the first three years of shelf life

    Science.gov (United States)

    Blecic, Deborah D.

    2000-01-01

    Objective: To study the circulation of monographs during the first three years of shelf life at an academic health sciences library. Method: A record was kept of monographs added to the circulating collection from mid-1994 to mid-1995. After three years, each monograph was located and the number of times it circulated during the first, second, and third year of shelf life determined by counting checkout stamps on the circulation slip. Results: Of the 1,958 monographs studied, 1,674 had complete data for the first three years of shelf life. Of those 1,674 titles, 81.48% circulated at least once. A total of 7,659 circulations were recorded; 38.69% occurred in the first year of shelf life, 32.37% in the second year, and 28.95% in the third year. The data did not fit the well-known 80/20 rule. Instead, approximately 38% of monographs accounted for 80% of circulation. A small percentage, 2.21%, of monographs accounted for a substantial percentage of circulation, 21.84%. Conclusions: A large percentage of the monographs circulated and use did not decline sharply with age within the first three years of shelf life, indicating a high demand for monographs at this academic health sciences library. These results, combined with the findings of earlier studies, suggested two possibilities. First, academic health sciences libraries might exhibit use of a higher percentage of monograph acquisitions than other types of libraries; or, second, a low monograph-to-user ratio might result in a higher percentage of monographs being used. Perhaps both factors contributed to the results found in this study. Further investigation would be needed to determine the extent to which library type and monograph-to-user ratio influenced monograph use. PMID:10783969

  6. The Impact of Socioeconomic Development and Ecological Change on Health and Nutrition in Latin America. Cornell International Nutrition Monograph Series, Number 9 (1981).

    Science.gov (United States)

    Solimano, Giorgio R.; Chapin, Georganne

    This monograph presents an examination of patterns which emerge from the interrelationship between development, environment, and health and nutrition in Latin America. First, the authors consider the components of this interrelationship, discussing the inseparability of health problems such as malnutrition, fecally-borne and parasitic diseases,…

  7. The Genetics Revolution: Programs and Issues for the Community College. A Monograph Highlighting the Winners of the Exxon Education Foundation Innovation Awards.

    Science.gov (United States)

    Mays, Marilyn Elaine, Ed.

    Presented at a 1996 conference on the implications of the Human Genome Project for community and technical colleges, the 30 papers included in this monograph describe methods for incorporating genetics studies into the two-year college curriculum. Among the papers provided are: (1) "Facing the Unknown: The Ethical Challenges of…

  8. Transfer Students in Higher Education: Building Foundations for Policies, Programs, and Services that Foster Student Success. The First-Year Experience Monograph Series No. 54

    Science.gov (United States)

    Poisel, Mark Allen, Ed.; Joseph, Sonya, Ed.

    2011-01-01

    "Transfer Students in Higher Education" presents what individuals know about transfer students, addresses assumptions and myths about the transfer experience, and explores the changing demographics of this student group. Adopting a student-centered approach, the monograph offers strategies to begin (and continue) the work of serving students and…

  9. Comparing Usage Patterns Recorded between an Electronic Reference and an Electronic Monograph Collection: The Differences in Searches and Full-Text Content Viewings

    Science.gov (United States)

    Lamothe, Alain R.

    2012-01-01

    This paper presents the results from a quantitative and systematic analysis comparing the online usage of an e-reference and an e-monograph collection. A very strong relationship exists between size and usage: the larger the collection, the greater the usage. An equally strong relationship exists between searches and viewings, meaning that the…

  10. Monograph of Arctium L. (Asteraceae). Generic delimitation (including Cousinia Cass, p.p.), revision of the species, pollen morphology, and hybrids

    NARCIS (Netherlands)

    Duistermaat, Helena

    1996-01-01

    The subject of this thesis is a monograph of the genus Arctium, now including also five species formerly placed into Cousinia. Based on herbarium material and some field observations, this study presents new insights on three subjects: a) the generic delimitation of Arctium, b) the species

  11. Comparing Usage Patterns Recorded between an Electronic Reference and an Electronic Monograph Collection: The Differences in Searches and Full-Text Content Viewings

    Science.gov (United States)

    Lamothe, Alain R.

    2012-01-01

    This paper presents the results from a quantitative and systematic analysis comparing the online usage of an e-reference and an e-monograph collection. A very strong relationship exists between size and usage: the larger the collection, the greater the usage. An equally strong relationship exists between searches and viewings, meaning that the…

  12. Monograph of Arctium L. (Asteraceae). Generic delimitation (including Cousinia Cass, p.p.), revision of the species, pollen morphology, and hybrids

    NARCIS (Netherlands)

    Duistermaat, Helena

    1996-01-01

    The subject of this thesis is a monograph of the genus Arctium, now including also five species formerly placed into Cousinia. Based on herbarium material and some field observations, this study presents new insights on three subjects: a) the generic delimitation of Arctium, b) the species delimitat

  13. ‘The Returned’: on the future of monographic books

    Directory of Open Access Journals (Sweden)

    Mercedes Bunz

    2014-04-01

    Full Text Available This article evaluates the current state of academic book publishing based on the findings of the Hybrid Publishing Lab's business model research. With students relying more and more on Google and Wikipedia, the role of books within today's university studies is a difficult one. From the perspective of publishers, open access (OA embracing the digital is seen as one potential way to bridge this gap between online search engines and traditional monographs. To illustrate this further, the article delivers an overview of its findings, which highlight changes in academic publishing: publishers have switched their emphasis from delivering a product to creating a service, whereby the author rather than the reader becomes their most focused-on customer. Research frameworks, funding and conventions about academic careers, however, often still need to adjust to this new development. If these frameworks acknowledge and foster OA publishing, and new experiments with collaborative book productions flourish, the monograph will have a future.

  14. Monograph on propagation of sound waves in curved ducts

    Science.gov (United States)

    Rostafinski, Wojciech

    1991-01-01

    After reviewing and evaluating the existing material on sound propagation in curved ducts without flow, it seems strange that, except for Lord Rayleigh in 1878, no book on acoustics has treated the case of wave motion in bends. This monograph reviews the available analytical and experimental material, nearly 30 papers published on this subject so far, and concisely summarizes what has been learned about the motion of sound in hard-wall and acoustically lined cylindrical bends.

  15. Circulation of core collection monographs in an academic medical library.

    Science.gov (United States)

    Schmidt, C M; Eckerman, N L

    2001-04-01

    Academic medical librarians responsible for monograph acquisition face a challenging task. From the plethora of medical monographs published each year, academic medical librarians must select those most useful to their patrons. Unfortunately, none of the selection tools available to medical librarians are specifically intended to assist academic librarians with medical monograph selection. The few short core collection lists that are available are intended for use in the small hospital or internal medicine department library. As these are the only selection tools available, however, many academic medical librarians spend considerable time reviewing these collection lists and place heavy emphasis on the acquisition of listed books. The study reported here was initiated to determine whether the circulation of listed books in an academic library justified the emphasis placed on the acquisition of these books. Circulation statistics for "listed" and "nonlisted" books in the hematology (WH) section of Indiana University School of Medicine's Ruth Lilly Medical Library were studied. The average circulation figures for listed books were nearly two times as high as the corresponding figures for the WH books in general. These data support the policies of those academic medical libraries that place a high priority on collection of listed books.

  16. Bibliometric analysis of martial arts monographs published in Spain (1906-2006

    Directory of Open Access Journals (Sweden)

    Mikel Pérez Gutiérrez

    2012-07-01

    Full Text Available This paper examines the martial arts monographs published in Spain between 1906 and 2006 from a bibliometric point of view. Starting from Pérez and Gutiérrez’s previous bibliography (2008, the total number of published monographs following the criteria of subject, decade and the combination of both was analyzed. The results showed a total of 2.036 books (1.285 original editions with a prevalence of Japanese and Chinese martial arts. A group of eight subjects exceeded a hundred volumes (karate, judo/jujutsu, taijiquan, wu-shu/kung fu, classics, qigong, philosophy, history and education, and aikido, with two patterns of bibliographic evolution appearing. The first, represented by Japanese martial arts considered as a group and martial arts focused on the utilitarian and/or sporting performance aspects (judo/jujutsu, karate and wu-shu/kung fu, developed increasingly until the 80’s when it followed a steady-state and/or drop. The second model, which characterises the Chinese martial arts group and martial arts mainly focused on healthy and/or spiritual aspects of training (taijiquan, qigong, aikido, has increased significantly from the 90’s until the present moment. The interpretation of these patterns and the evolution of the martial arts bibliographic production in Spain highlights some aspects such as the development of the Spanish society and sports practice, bibliographic production, reading habits, or the cultural influences of eastern countries on Spain.

  17. Development of monograph titled "augmented chemistry aldehida & keton" with 3 dimensional (3D) illustration as a supplement book on chemistry learning

    Science.gov (United States)

    Damayanti, Latifah Adelina; Ikhsan, Jaslin

    2017-05-01

    Integration of information technology in education more rapidly performed in a medium of learning. Three-dimensional (3D) molecular modeling was performed in Augmented Reality as a tangible manifestation of increasingly modern technology utilization. Based on augmented reality, three-dimensional virtual object is projected in real time and the exact environment. This paper reviewed the uses of chemical learning supplement book of aldehydes and ketones which are equipped with three-dimensional molecular modeling by which students can inspect molecules from various viewpoints. To plays the 3D illustration printed on the book, smartphones with the open-source software of the technology based integrated Augmented Reality can be used. The aims of this research were to develop the monograph of aldehydes and ketones with 3 dimensional (3D) illustrations, to determine the specification of the monograph, and to determine the quality of the monograph. The quality of the monograph is evaluated by experiencing chemistry teachers on the five aspects of contents/materials, presentations, language and images, graphs, and software engineering, resulted in the result that the book has a very good quality to be used as a chemistry learning supplement book.

  18. A MONOGRAPH OF THE GENUS DIPLODISCUS* Turcz. (TILIACEAE

    Directory of Open Access Journals (Sweden)

    A. J. G. H. KOSTERMANS

    2014-01-01

    Full Text Available 1. Seven species of the genus Diplodiscus are described, of which three(D. microlepis, D. parviflorus and D. decumbens are new to science, and one (D. hookerianus was formerly described as Pentace (for the description of D. decumbens cf. p. 264.2. The area of distribution of the genus covers the Malay Peninsula,Borneo and the Philippines.3. The affinities of the genus are discussed.4. A key to the species is presented.

  19. Descriptive Research

    DEFF Research Database (Denmark)

    Wigram, Anthony Lewis

    2003-01-01

    Descriptive research is described by Lathom-Radocy and Radocy (1995) to include Survey research, ex post facto research, case studies and developmental studies. Descriptive research also includes a review of the literature in order to provide both quantitative and qualitative evidence of the effect...... starts will allow effect size calculations to be made in order to evaluate effect over time. Given the difficulties in undertaking controlled experimental studies in the creative arts therapies, descriptive research methods offer a way of quantifying effect through descriptive statistical analysis...

  20. Diagnostic conundrums in antenatal presentation of a skeletal dysplasia with description of a heterozygous C-propeptide mutation in COL1A1 associated with a severe presentation of osteogenesis imperfecta.

    Science.gov (United States)

    Marshall, Charlotte J; Arundel, Paul; Mushtaq, Talat; Offiah, Amaka C; Pollitt, Rebecca C; Bishop, Nicholas J; Balasubramanian, Meena

    2016-12-01

    Prompt and accurate diagnosis of skeletal dysplasias can play a crucial role in ensuring appropriate counseling and management (both antenatal and postnatal). When a skeletal dysplasia is detected during the antenatal period, especially early in the pregnancy, it can be associated with a poor prognosis. It is important to make a diagnosis in antenatal presentation of skeletal dysplasias to inform diagnosis, predict prognosis, provide accurate recurrence risks, and options for prenatal genetic testing in future pregnancies. Prenatal ultrasound scanning is a useful tool to detect several skeletal dysplasias and sonographic measurements serve as reliable indicators of lethality. The lethality depends on various factors including gestational age at which features are identified, size of the chest and progression of malformations. Although, it is important to type the skeletal presentation as accurately as possible, this is not always possible in an antenatal presentation and it is important to acknowledge this uncertainty. In the case of a live birth, it is always important to reassess the infant. Osteogenesis imperfecta (OI) is a heterogeneous group of disorders characterized by fragile bones. Here, we report an infant with severe OI born following a twin pregnancy in whom the bone disease is caused by a heterozygous pathogenic mutation, c.4160C >T, p.(Ala1387Val) located in the C-propeptide region of COL1A1. An assumption of lethality antenatally complicated his management in early life. We discuss this patient with particular emphasis on the neonatal presentation of a severe skeletal dysplasia and the lessons that may be learned in such situations. © 2016 Wiley Periodicals, Inc.

  1. Higher Education in the Republic of Moldova. Monographs on Higher Education.

    Science.gov (United States)

    Tiron, Stefan; Arion, Valentin; Paiu, Mihai; Scalini, Vitalie; Stan, Victor

    This monograph parallels others in the "Monographs" series, allowing easy comparisons among the higher education systems of Europe. The volume describes the development of the higher education system in the Republic of Moldava and analyzes its legislative framework and administrative structures. It outlines steps on the academic career ladder and…

  2. J. W. Gitt: The Cold War's "Voice in the Wilderness." Journalism Monographs Number Ninety-One.

    Science.gov (United States)

    Hamilton, Mary Allienne

    This journalism monograph deals with Josiah W. Gitt and his newspaper, "The Gazette and Daily," which existed from 1915 to 1970 and was referred to as "the voice in the wilderness" because of its stand on controversial issues. The monograph discusses the "Gazette and Daily," its views, Gitt's employees, the…

  3. The Caribbean News Agency: Third World Model. Journalism Monographs Number 71.

    Science.gov (United States)

    Cuthbert, Marlene

    This monograph is a history of the Caribbean News Agency (CANA), which is jointly owned by private and public mass media of its region and independent of both governments and foreign news agencies. It is proposed that CANA may provide a unique model of an independent, regional third-world news agency. Sections of the monograph examine (1) CANA's…

  4. Use of High Throughput Screening Data in IARC Monograph Evaluations (SOT)

    Science.gov (United States)

    Purpose: Evaluation of carcinogenic mechanisms serves a critical role in IARC monograph evaluations, and can lead to “upgrade” or “downgrade” of the carcinogenicity conclusions based on human and animal evidence alone. Three recent IARC monograph Working Groups (110, 112, and 11...

  5. 76 FR 61704 - Availability of Draft NTP Monograph on the Health Effects of Low-Level Lead; Request for Comments...

    Science.gov (United States)

    2011-10-05

    ... HUMAN SERVICES Availability of Draft NTP Monograph on the Health Effects of Low- Level Lead; Request for Comments; Announcement of a Panel Meeting to Peer Review Draft Monograph AGENCY: Division of the National... of Health. ACTION: Availability of Draft NTP Monograph; Request for Comments; Announcement of a Peer...

  6. 76 FR 55391 - Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental Effects of...

    Science.gov (United States)

    2011-09-07

    ... HUMAN SERVICES Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy During Pregnancy and Panel Meeting To Peer Review Draft Monograph AGENCY... (NIEHS), National Institutes of Health. ACTION: Notice of postponement of draft NTP monograph and peer...

  7. 78 FR 67371 - Draft Report on Carcinogens Monographs for ortho-Toluidine and Pentachlorophenol and By-products...

    Science.gov (United States)

    2013-11-12

    ... HUMAN SERVICES National Institutes of Health Draft Report on Carcinogens Monographs for ortho-Toluidine... Report on Carcinogens (RoC) Monographs for ortho-Toluidine and Pentachlorophenol and By-products of its... a.m. until adjournment, approximately 11:30 a.m. Document Availability: Draft monographs...

  8. 78 FR 51733 - Draft Report on Carcinogens Monographs for ortho-Toluidine and Pentachlorophenol and By-Products...

    Science.gov (United States)

    2013-08-21

    ... HUMAN SERVICES National Institutes of Health Draft Report on Carcinogens Monographs for ortho-Toluidine... Carcinogens (RoC) Monographs for ortho-Toluidine and Pentachlorophenol and By-products of its Synthesis.... Document Availability: Draft monographs will be available by August 28, 2013, at...

  9. Preliminary description of aging cats and dogs presented to a New Zealand first-opinion veterinary clinic at end-of-life.

    Science.gov (United States)

    Gates, M C; Hinds, H J; Dale, A

    2017-08-09

    AIMS To conduct a preliminary investigation into the chronic disease conditions and clinical signs present in aging New Zealand companion animals at end-of-life and to describe the timing, circumstances, and manner of death. METHODS The medical records database of a first-opinion, companion animal, veterinary practice in Auckland, New Zealand was searched to identify all canine and feline patients ≥7 years of age that were subjected to euthanasia or cremated in the period between July 2012-June 2014. The free-text medical notes were analysed for information on the circumstances surrounding the death, previous diagnoses of chronic disease conditions, and the presence of clinical signs associated with decreased quality-of-life at the time of euthanasia. RESULTS The median age at death was 15 (max 22) years for the 130 cats and 12 (max 17) years for the 68 dogs in the study sample. Euthanasia at the clinic was carried out for 119/130 (91%) cats and 62/68 (91%) dogs, with the remainder recorded as having an unassisted death. The frequency of deaths was highest during December for both cats and dogs. Cost was mentioned as an issue in the medical records for 39/181 (21.6%) patients that were subjected to euthanasia. At the time of euthanasia, 92/119 (77.3%) cats and 43/62 (69.4%) dogs were recorded as having >1 clinical sign associated with a decreased quality-of-life. Inappetence and non-specific decline were the two most commonly recorded clinical signs for both dogs and cats. Cardiovascular disease (44/130, 34%), renal failure (40/130, 31%), and malignant neoplasia (36/130, 28%) were the most common chronic disease conditions recorded for cats. Degenerative joint disease (22/68, 32%), malignant neoplasia (14/68, 21%), and cardiovascular disease (8/68, 12%) were the most common chronic disease conditions recorded for dogs. CONCLUSIONS AND CLINICAL RELEVANCE These preliminary findings highlight that aging companion animals in New Zealand frequently have chronic

  10. [The HMPC monograph on Hypericum: Background, development, contents].

    Science.gov (United States)

    Länger, Reinhard

    2010-12-01

    The adoption of the EU community monograph on Hypericum constitutes a milestone in the process of harmonisation of herbal medicinal products within the European Community. The assessment of the published clinical data revealed that for two types of extracts the evidence of the efficacy in mild to moderate depressive episodes compared to placebo or standard medication was found to be acceptable. Additionally, a sufficient efficacy in relapse prophylaxis could be demonstrated for these two herbal preparations. For some other dry extracts, the efficacy in the short-term treatment of symptoms in mild depressive disorders was found to be substantiated. Short-term treatment with preparations containing low amounts of hyperforin did not increase cytochrome P450 enzyme activity. Therefore the oral administration of traditional herbal preparations is restricted to two weeks. In the case that an applicant demonstrates that the daily intake of hyperforin is below 1 mg the warnings on interactions may be omitted in traditional herbal medicinal products. Additionally the cutaneous administration of traditional liquid herbal preparations for the traditional use in symptomatic treatment of minor inflammations of the skin and as an aid in healing minor wounds was included in the monograph.

  11. Revisiting an open access monograph experiment: measuring citations and tweets 5 years later.

    Science.gov (United States)

    Snijder, Ronald

    2016-01-01

    An experiment run in 2009 could not assess whether making monographs available in open access enhanced scholarly impact. This paper revisits the experiment, drawing on additional citation data and tweets. It attempts to answer the following research question: does open access have a positive influence on the number of citations and tweets a monograph receives, taking into account the influence of scholarly field and language? The correlation between monograph citations and tweets is also investigated. The number of citations and tweets measured in 2014 reveal a slight open access advantage, but the influence of language or subject should also be taken into account. However, Twitter usage and citation behaviour hardly overlap.

  12. Descriptive Research

    DEFF Research Database (Denmark)

    Wigram, Anthony Lewis

    2003-01-01

    Descriptive research is described by Lathom-Radocy and Radocy (1995) to include Survey research, ex post facto research, case studies and developmental studies. Descriptive research also includes a review of the literature in order to provide both quantitative and qualitative evidence of the effect...... of music therapy with a specific population (Gold, Voracek & Wigram, Wigram, 2002). The collection of such evidence, through surveys of the literature and documentation of music therapy studies that show effect with a specified population are becoming increasingly important in order to underpin music...

  13. Automatic identification and normalization of dosage forms in drug monographs

    Directory of Open Access Journals (Sweden)

    Li Jiao

    2012-02-01

    Full Text Available Abstract Background Each day, millions of health consumers seek drug-related information on the Web. Despite some efforts in linking related resources, drug information is largely scattered in a wide variety of websites of different quality and credibility. Methods As a step toward providing users with integrated access to multiple trustworthy drug resources, we aim to develop a method capable of identifying drug's dosage form information in addition to drug name recognition. We developed rules and patterns for identifying dosage forms from different sections of full-text drug monographs, and subsequently normalized them to standardized RxNorm dosage forms. Results Our method represents a significant improvement compared with a baseline lookup approach, achieving overall macro-averaged Precision of 80%, Recall of 98%, and F-Measure of 85%. Conclusions We successfully developed an automatic approach for drug dosage form identification, which is critical for building links between different drug-related resources.

  14. Acacia mangium: Growing and utilization. MPTS monograph series No. 3

    Energy Technology Data Exchange (ETDEWEB)

    Awang, K.; Taylor, D.

    1993-01-01

    With deforestation in the Asia-Pacific region progressing at the rate of 4.4 million ha per year, many countries have adopted plantation forestry using fast-growing species as a way to sustain the commercial supply of tree products and reduce pressure on natural forests. Acacia mangium (A. mangium) is playing a large role in this development, especially in Indonesia and Malaysia, due to its versatility and its ability to recapture grasslands dominated by the noxious weed, Imperata cylindrica. This monograph consolidates information on A. mangium from published literature, unpublished reports and studies, and observations from those familiar with the species. Priorities for future research are included in each chapter and in the final summary.

  15. A Comprehensive List of Items to be Included on a Pediatric Drug Monograph.

    Science.gov (United States)

    Kelly, Lauren E; Ito, Shinya; Woods, David; Nunn, Anthony J; Taketomo, Carol; de Hoog, Matthijs; Offringa, Martin

    2017-01-01

    Children require special considerations for drug prescribing. Drug information summarized in a formulary containing drug monographs is essential for safe and effective prescribing. Currently, little is known about the information needs of those who prescribe and administer medicines to children. Our primary objective was to identify a list of important and relevant items to be included in a pediatric drug monograph. Following the establishment of an expert steering committee and an environmental scan of adult and pediatric formulary monograph items, 46 participants from 25 countries were invited to complete a 2-round Delphi survey. Questions regarding source of prescribing information and importance of items were recorded. An international consensus meeting to vote on and finalize the items list with the steering committee followed. Pediatric formularies are most commonly the first resource consulted for information on medication used in children by 31 Delphi participants. After the Delphi rounds, 116 items were identified to be included in a comprehensive pediatric drug monograph, including general information, adverse drug reactions, dosages, precautions, drug-drug interactions, formulation, and drug properties. Health care providers identified 116 monograph items as important for prescribing medicines for children by an international consensus-based process. This information will assist in setting standards for the creation of new pediatric drug monographs for international application and for those involved in pediatric formulary development.

  16. Emergent Practices in the Continuing Education of School Administrators. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM State-of-the-Knowledge Series, Number Sixteen. UCEA Monograph Series, Number Three.

    Science.gov (United States)

    Lutz, Frank W.; Ferrante, Reynolds

    In this monograph, the authors describe the shortcomings of traditional approaches to continuing education of administrators and examine the extent to which innovations are being attempted in present practices. The authors note that, in print and in practice, continuing education of administrators has failed to develop to the extent that it can be…

  17. The UNO Aviation Monograph Series: The Airline Quality Rating 1998

    Science.gov (United States)

    Bowen, Brent D.; Headley, Dean E.

    1998-01-01

    The Airline Quality Rating (AQR) was developed and first announced in early 1991 as an objective method of comparing airline performance on combined multiple factors important to consumers. Development history and calculation details for the AQR rating system are detailed in The Airline Quality Rating 1991 issued in April, 1991, by the National Institute for Aviation Research at Wichita State University. This current report, Airline Quality Rating 1998, contains monthly Airline Quality Rating scores for 1997. Additional copies are available by contacting Wichita State University or University of Nebraska at Omaha. The Airline Quality Rating 1998 is a summary of month-by-month quality ratings for the ten major U.S. airlines operating during 1997. Using the Airline Quality Rating system and monthly performance data for each airline for the calendar year of 1997, individual and comparative ratings are reported. This research monograph contains a brief summary of the AQR methodology, detailed data and charts that track comparative quality for major airlines domestic operations for the 12 month period of 1997, and industry average results. Also, comparative Airline Quality Rating data for 1991 through 1996 are included to provide a longer term view of quality in the industry.

  18. The UNO Aviation Monograph Series: The Airline Quality Rating 1997

    Science.gov (United States)

    Bowen, Brent D.; Headley, Dean E.

    1997-01-01

    The Airline Quality Rating (AQR) was developed and first announced in early 1991 as an objective method of comparing airline performance on combined multiple factors important to consumers. Development history and calculation details for the AQR rating system are detailed in The Airline Quality Rating 1991 issued in April, 1991, by the National Institute for Aviation Research at Wichita State University. This current report, Airline Rating 1997, contains monthly Airline Quality Rating scores for 1996. Additional copies are available by contacting Wichita State University or the University of Nebraska at Omaha. The Airline Quality Rating (AQR) 1997 is a summary of a month-by-month quality ratings for the nine major domestic U.S. airlines operating during 1996. Using the Airline Quality Rating system and monthly performance data for each airline for the calendar year of 1996, individual and comparative ratings are reported. This research monograph contains a brief summary of the AQR methodology, detailed data and charts that track comparative quality for major domestic airlines across the 12 month period of 1996, and industry average results. Also comparative Airline Quality Rating data for 1991 through 1995 are included to provide a longer term view of quality in the industry.

  19. Droughts in the Czech Lands: Past, Present and Future

    Science.gov (United States)

    Brázdil, Rudolf; Trnka, Miroslav

    2015-04-01

    The presentation highlights main results of the InterDrought project (2013-2015), which includes several Czech universities and research institutes, and also shows overview of multidisciplinary scientific monograph on drought. The basic data sources consisting of instrumental, documentary, tree-ring and satellite data are presented. Selected drought indices (SPI, SPEI, Z-index and PDSI) calculated from homogenised Czech temperature and precipitation series are used to describe spatial and temporal variability of droughts in the Czech Lands for the 1804-2010 period including selection of drought extreme episodes and their detail description with respect to meteorological and synoptic patterns and impacts as well. Analysis of droughts prior 1804 is based on documentary data and oak tree-ring widths used for compilation of 500-year Czech drought chronology. The occurrence of extreme droughts is further analysed with respect to sea-level pressure patterns in the Atlantic-European area, climate forcings and changes in land-use. Examples of agricultural and hydrological droughts are mentioned. High resolution soil moisture models are used to estimate drought trends in last five decades as well as estimate future development of droughts in the Czech Republic. Overview represented by this paper will be complemented by several individual detail studies of other InterDrought Team members.

  20. Biowaiver monographs for immediate-release solid oral dosage forms: codeine phosphate.

    Science.gov (United States)

    Dahan, Arik; Wolk, Omri; Zur, Moran; Amidon, Gordon L; Abrahamsson, Bertil; Cristofoletti, Rodrigo; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2014-06-01

    The present monograph reviews data relevant to applying the biowaiver procedure for the approval of immediate-release multisource solid dosage forms containing codeine phosphate. Both biopharmaceutical and clinical data of codeine were assessed. Solubility studies revealed that codeine meets the "highly soluble" criteria according to World Health Organization (WHO), the European Medicines Agency (EMA), and the United States Food and Drug Administration (US FDA). Codeine's fraction of dose absorbed in humans was reported to be high (>90%) based on cumulative urinary excretion of drug and drug-related material following oral administration. The permeability of codeine was also assessed to be high in both Caco-2 monolayers and rat intestinal perfusion studies. The main risks associated with codeine, that is, toxicity (attributed to CYP2D6 polymorphism) and its abuse potential, are present irrespective of the dosage form, and do not need to be taken into account for bioequivalence (BE) considerations. Taken together, codeine is a class 1 drug with manageable risk and is a good candidate for waiver of in vivo BE studies.

  1. Towards iconic language for patient records, drug monographs, guidelines and medical search engines.

    Science.gov (United States)

    Lamy, Jean-Baptiste; Duclos, Catherine; Hamek, Saliha; Beuscart-Zéphir, Marie-Catherine; Kerdelhué, Gaetan; Darmoni, Stefan; Favre, Madeleine; Falcoff, Hector; Simon, Christian; Pereira, Suzanne; Serrot, Elisabeth; Mitouard, Thierry; Hardouin, Etienne; Kergosien, Yannick; Venot, Alain

    2010-01-01

    Practicing physicians have limited time for consulting medical knowledge and records. We have previously shown that using icons instead of text to present drug monographs may allow contraindications and adverse effects to be identified more rapidly and more accurately. These findings were based on the use of an iconic language designed for drug knowledge, providing icons for many medical concepts, including diseases, antecedents, drug classes and tests. In this paper, we describe a new project aimed at extending this iconic language, and exploring the possible applications of these icons in medicine. Based on evaluators' comments, focus groups of physicians and opinions of academic, industrial and associative partners, we propose iconic applications related to patient records, for example summarizing patient conditions, searching for specific clinical documents and helping to code structured data. Other applications involve the presentation of clinical practice guidelines and improving the interface of medical search engines. These new applications could use the same iconic language that was designed for drug knowledge, with a few additional items that respect the logic of the language.

  2. A taxonomic monograph of Nearctic Scolytus Geoffroy (Coleoptera, Curculionidae, Scolytinae

    Directory of Open Access Journals (Sweden)

    Sarah Smith

    2014-10-01

    Full Text Available The Nearctic bark beetle genus Scolytus Geoffroy was revised based in part on a molecular and morphological phylogeny. Monophyly of the native species was tested using mitochondrial (COI and nuclear (28S, CAD, ArgK genes and 43 morphological characters in parsimony and Bayesian phylogenetic analyses. Parsimony analyses of molecular and combined datasets provided mixed results while Bayesian analysis recovered most nodes with posterior probabilities >90%. Native hardwood- and conifer-feeding Scolytus species were recovered as paraphyletic. Native Nearctic species were recovered as paraphyletic with hardwood-feeding species sister to Palearctic hardwood-feeding species rather than to native conifer-feeding species. The Nearctic conifer-feeding species were monophyletic. Twenty-five species were recognized. Four new synonyms were discovered: S. praeceps LeConte, 1868 (= S. abietis Blackman, 1934; = S. opacus Blackman, 1934, S. reflexus Blackman, 1934 (= S. virgatus Bright, 1972; = S. wickhami Blackman, 1934. Two species were reinstated: S. fiskei Blackman, 1934 and S. silvaticus Bright, 1972. A diagnosis, description, distribution, host records and images were provided for each species and a key is presented to all species.

  3. A taxonomic monograph of Nearctic Scolytus Geoffroy (Coleoptera, Curculionidae, Scolytinae).

    Science.gov (United States)

    Smith, Sarah M; Cognato, Anthony I

    2014-01-01

    The Nearctic bark beetle genus Scolytus Geoffroy was revised based in part on a molecular and morphological phylogeny. Monophyly of the native species was tested using mitochondrial (COI) and nuclear (28S, CAD, ArgK) genes and 43 morphological characters in parsimony and Bayesian phylogenetic analyses. Parsimony analyses of molecular and combined datasets provided mixed results while Bayesian analysis recovered most nodes with posterior probabilities >90%. Native hardwood- and conifer-feeding Scolytus species were recovered as paraphyletic. Native Nearctic species were recovered as paraphyletic with hardwood-feeding species sister to Palearctic hardwood-feeding species rather than to native conifer-feeding species. The Nearctic conifer-feeding species were monophyletic. Twenty-five species were recognized. Four new synonyms were discovered: Scolytuspraeceps LeConte, 1868 (= Scolytusabietis Blackman, 1934; = Scolytusopacus Blackman, 1934), Scolytusreflexus Blackman, 1934 (= Scolytusvirgatus Bright, 1972; = Scolytuswickhami Blackman, 1934). Two species were reinstated: Scolytusfiskei Blackman, 1934 and Scolytussilvaticus Bright, 1972. A diagnosis, description, distribution, host records and images were provided for each species and a key is presented to all species.

  4. Biowaiver monographs for immediate-release solid oral dosage forms: quinine sulfate.

    Science.gov (United States)

    Strauch, Stefanie; Dressman, Jennifer B; Shah, Vinod P; Kopp, Sabine; Polli, James E; Barends, Dirk M

    2012-02-01

    The biowaiver approach permits evaluation of bioequivalence (BE) using a set of laboratory tests, obviating the need for expensive and time-consuming pharmacokinetic BE studies provided that both the active pharmaceutical ingredient and the formulations can meet the specified criteria. In the present monograph, the biowaiver-relevant data including solubility and permeability data, therapeutic use and therapeutic index, pharmacokinetic properties, reported excipient interactions, and BE/bioavailability studies of quinine sulfate are itemized and discussed. Quinine sulfate has borderline solubility characteristics and, on the whole, is highly permeable. Thus, depending on the jurisdiction, it is assigned to Biopharmaceutics Classification System class I or II. Although these characteristics would suggest a low risk of bioinequivalence among oral quinine products, a recent pharmacokinetic study showed bioinequivalence of two products. Even though quinine does not, strictly speaking, fit the definition of a narrow therapeutic index drug, it shows dose-related and, in some cases, irreversible side effects and toxicities at concentrations not far above the therapeutic concentration range. Taking all relevant aspects into consideration, a biowaiver cannot be recommended for new quinine immediate-release multisource products or major post-approval changes of already marketed quinine products, and in such cases, BE should be evaluated using an in vivo BE study.

  5. Metrics and Science Monograph Collections at the Marston Science Library, University of Florida

    Directory of Open Access Journals (Sweden)

    Stephanie C. Haas

    2010-01-01

    Full Text Available As academic libraries are increasingly supported by a matrix of database functions, the use of data mining and visualization techniques offer significant potential for future collection development and service initiatives based on quantifiable data. While data collection techniques are still not standardized and results may be skewed because of granularity problems, faulty algorithms, and a host of other factors, useful baseline data is extractable and broad trends can be identified.The purpose of the current study is to provide an initial assessment of data associated with science monograph collection at the Marston Science Library (MSL, University of Florida. These sciences fall within the major Library of Congress Classification schedules of Q, S, and T, excluding TR, TT, and TX. The Rs are also excluded as these subjects are the responsibility of the Health Science Center Library which is connected with the medical school and the teaching hospital. The overall strategy of this project is to look at the potential science audiences within the university community and analyze data related to purchasing and circulation patterns, e-book usage, and interlibrary loan (ILL statistics. This paper presents the results from the academic year July 1, 2008 to June 30, 2009, because all data reservoirs needed were available for the circulation and ILL data. The Springer e-book study is based on 2009 data. The research team consisted of both librarians and technical support staff from MSL, the Acquisitions Department, the Cataloging Department, and the IT Department.

  6. Biowaiver monograph for immediate-release solid oral dosage forms: acetylsalicylic acid.

    Science.gov (United States)

    Dressman, Jennifer B; Nair, Anita; Abrahamsson, Bertil; Barends, Dirk M; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Zimmer, Markus

    2012-08-01

    A biowaiver monograph for acetylsalicylic acid (ASA) is presented. Literature and experimental data indicate that ASA is a highly soluble and highly permeable drug, leading to assignment of this active pharmaceutical ingredient (API) to Class I of the Biopharmaceutics Classification System (BCS). Limited bioequivalence (BE) studies reported in the literature indicate that products that have been tested are bioequivalent. Most of the excipients used in products with a marketing authorization in Europe are not considered to have an impact on gastrointestinal motility or permeability. Furthermore, ASA has a wide therapeutic index. Thus, the risks to the patient that might occur if a nonbioequivalent product were to be incorrectly deemed bioequivalent according to the biowaiver procedure appear to be minimal. As a result, the BCS-based biowaiver procedure can be recommended for approval of new formulations of solid oral dosage forms containing ASA as the only API, including both multisource and reformulated products, under the following conditions: (1) excipients are chosen from those used in ASA products already registered in International Conference on Harmonization and associated countries and (2) the dissolution profiles of the test and the comparator products comply with the BE guidance. Copyright © 2012 Wiley Periodicals, Inc.

  7. Book review: Peregruznoe I Burial Ground: Results of Interdisciplinary Research : Monograph [Text] / M. A. Balabanova, E. V. Pererva [at al.]. – Volgograd : Izd-vo Volgogradskogo Filiala FGBOU VPO RANHiGS, 2014. – 360 p.

    Directory of Open Access Journals (Sweden)

    Tairov Aleksandr Dmitrievich

    2016-04-01

    Full Text Available The review concerns the monograph “Peregruznoe I Burial Ground: Results of Interdisciplinary Research. The book was prepared by the team of authors including archaeologists, anthropologists, paleosoil specialists, archaeozoologists. The review contains examination of materials and main conclusions for every chapter of the monograph. The monograph is devoted to the analysis of materials from 52 burial mounds dated from the Aeneolith to the Middle Ages. Most of them were erected in the Sarmatian period. In the review, the controversial points concerning the reconstruction of the paleodemographic and physicalgenetic structure of the buried Sarmatian population were pointed out. The authors consider that the gender disharmony of the Early and Middle Sarmatian samples was determined by the peculiarities of mounds formation of nomadic groups localized at the winter and summer nomad camps. This conclusion provokes some objections. As a positive moment, it should be noted that the authors have discovered new trends by means of analysis of cultural and chronological Sarmatian groups according to anthropological data. The monograph presents new interesting data related to reconstruction of the social structure of the Sarmatian societies, burial mound construction, the taxonomic composition of animals from grave pits and mounds. It is necessary to note, that the authors carried out a great deal of investigation and study. The monograph presents abundant scientific data. Interpretation of this material has a great potential which resources are far from being exhausted. The book is going to be a significant event not only for the study of the Volga-Ural steppe antiquities but for all over the Sarmatian archaeology.

  8. Mathematical description of the heat transfer in living tissue, 1

    CERN Document Server

    Lubashevsky, I A

    1999-01-01

    In the present monograph we formulate a simple model for heat transfer in living tissue with self - regulation. The initial point of the model is the governing equations describing heat transfer in living tissue at the mesoscopic level, i.e. considering different vessels individually. Then, basing on the well known equivalence of the diffusion type process and random walks, we develop a certain regular procedure that enables us to average these mesoscopic equations practically over all scales of the hierarchical vascular network. The microscopic governing equations obtained in this way describe living tissue in terms of an active medium with continuously distributed self - regulation. One of the interesting results obtained in the present monograph is that there can be the phenomena of ideal self - regulation in large active hierarchical systems. Large hierarchical systems are characterized by such a great information flow that none of its elements can possess whole information required of governing the syste...

  9. Writing about Class and Race Differences and Similarities in Early Childhood Mathematics: The Case of One Monograph

    Science.gov (United States)

    Parks, Amy Noelle

    2015-01-01

    This article reports on a literature review of 49 articles that cited a single monograph East Lansing written in 1981 about early learning in mathematics to make claims of similarity or difference across lines of race and class in early mathematics. The review found that while about two-thirds of the articles cited the monograph to make claims of…

  10. Writing about Class and Race Differences and Similarities in Early Childhood Mathematics: The Case of One Monograph

    Science.gov (United States)

    Parks, Amy Noelle

    2015-01-01

    This article reports on a literature review of 49 articles that cited a single monograph East Lansing written in 1981 about early learning in mathematics to make claims of similarity or difference across lines of race and class in early mathematics. The review found that while about two-thirds of the articles cited the monograph to make claims of…

  11. Access to Basic Education in Ghana: Politics, Policies and Progress. CREATE Pathways to Access. Research Monograph No. 42

    Science.gov (United States)

    Little, Angela W.

    2010-01-01

    This monograph examines the history and politics of educational reform in Ghana. Using data from interviews conducted with senior policy-makers, implementers and researchers, as well as documentary sources, to explore the drivers and inhibitors of change at the political, bureaucratic and grass-roots levels. The monograph explores the nature of…

  12. ŞTEFANIA CRISTESCU AND THE „MONOGRAPHIC RESEARCH CRISIS”, 1932–1934

    Directory of Open Access Journals (Sweden)

    Professor ZOLTÁN ROSTÁS

    2013-05-01

    Full Text Available This article analyzes the crisis of the monographic research undertaken by the Sociological School from Bucharest (led by Professor Dimitrie Gusti, between 1932–1933. The focus is on the particular perspective offered by one salient member of the group, Ştefania Cristescu-Golopenţia. The internal reason of the “monograph crisis” was the change in status and orientation of the young members of the School, a transformation that – at least in the case of Şt. C.-G. – disturbed her research work, but did not prevent her from carrying out outstanding studies

  13. Harmonization of monographic standards is needed to ensure the quality of Chinese medicinal materials

    Directory of Open Access Journals (Sweden)

    Zhao Sandy

    2009-09-01

    Full Text Available Abstract This article provides an overview on the regulations of Chinese medicinal materials (CMMs in various countries and regions. Harmonization of CMM monographs would provide standards for the quality control of CMM products and play an important role in the modernization and globalization of Chinese medicine. A harmonized regulatory system would improve the quality of CMMs thereby ensuring the safety of the products and assisting Chinese medicine practitioners in their practice. The fast growing demand worldwide for traditional medicines calls for harmonized monographic standards to safeguard the safety and quality of CMM products.

  14. A description of the global land-surface precipitation data products of the Global Precipitation Climatology Centre with sample applications including centennial (trend analysis from 1901–present

    Directory of Open Access Journals (Sweden)

    A. Becker

    2013-02-01

    Full Text Available The availability of highly accessible and reliable monthly gridded data sets of global land-surface precipitation is a need that was already identified in the mid-1980s when there was a complete lack of globally homogeneous gauge-based precipitation analyses. Since 1989, the Global Precipitation Climatology Centre (GPCC has built up its unique capacity to assemble, quality assure, and analyse rain gauge data gathered from all over the world. The resulting database has exceeded 200 yr in temporal coverage and has acquired data from more than 85 000 stations worldwide. Based on this database, this paper provides the reference publication for the four globally gridded monthly precipitation products of the GPCC, covering a 111-yr analysis period from 1901–present. As required for a reference publication, the content of the product portfolio, as well as the underlying methodologies to process and interpolate are detailed. Moreover, we provide information on the systematic and statistical errors associated with the data products. Finally, sample applications provide potential users of GPCC data products with suitable advice on capabilities and constraints of the gridded data sets. In doing so, the capabilities to access El Niño–Southern Oscillation (ENSO and North Atlantic Oscillation (NAO sensitive precipitation regions and to perform trend analyses across the past 110 yr are demonstrated. The four gridded products, i.e. the Climatology (CLIM V2011, the Full Data Reanalysis (FD V6, the Monitoring Product (MP V4, and the First Guess Product (FG, are publicly available on easily accessible latitude/longitude grids encoded in zipped clear text ASCII files for subsequent visualization and download through the GPCC download gate hosted on ftp://ftp.dwd.de/pub/data/gpcc/html/download_gate.html by the Deutscher Wetterdienst (DWD, Offenbach, Germany. Depending on the product, four (0.25°, 0.5°, 1.0°, 2.5° for CLIM, three (0.5°, 1.0°, 2.5°, for FD

  15. RDA描述的不同:以普通图书为例%Differences of RDA Cataloging: Focus on Monograph

    Institute of Scientific and Technical Information of China (English)

    王忠红

    2012-01-01

    以普通图书为重点,论述RDA著录的不同。文章先概述RDA基本理念和条例组织,然后以著录项目为序,逐项说明其不同之处,包括著录信息来源、著录方式以及检索点的获取。稍议RDA的利弊以及对编目馆员工作和OPAC的影响。%This paper discusses differences of RDA cataloging from AACR2 with a focus on monograph. It first discusses the RDA rules, and then the differences in description areas. It covers differences in sources of information, transcription and choosing of access points. In the end, discusses its impact on the cataloging work and OPAC, and makes a conclusion.

  16. Methadone Diversion: Experiences and Issues. Services Research Monograph Series.

    Science.gov (United States)

    Inciardi, James A.

    This report is a description of the phenomenon of methadone diversion as it exists now and places it in the context of prior research in this area. The intent here is to clarify issues around methadone diversion and to provide guidance to treatment administrators and program planners regarding efforts they can initiate to monitor this significant…

  17. Working toward a Continuum of Professional Learning Experiences for Teachers of Science and Mathematics. Research Monograph.

    Science.gov (United States)

    Mundry, Susan; Spector, Barbara; Stiles, Katherine; Loucks-Horsley, Susan

    This monograph is the result of a one-year qualitative study conducted by the National Institute for Science Education (NISE) of reform-oriented interventions, structures, and relationships in preservice and inservice education of teachers of science and mathematics. The study investigated 61 initiatives of reform activity involving teachers of…

  18. Herbert L. Matthews and the Cuban Story. Journalism Monographs No. 54.

    Science.gov (United States)

    Knudson, Jerry W.

    Herbert L. Matthews, a veteran journalist for the "New York Times," traveled to Cuba in 1957 to interview Fidel Castro, then a revolutionary seeking the overthrow of the Batista regime. This monograph considers the impact of Matthews' newspaper articles about those interviews and of his subsequent articles about the Cuban situation and…

  19. Procedures for Inventorying and Replacing Missing Monographs in a Large Research Library.

    Science.gov (United States)

    Shaughnessy, Thomas W.

    Divided into inventory project procedures for the identification of missing books for future replacement and inventory guidelines for use by subject librarians to determine whether an item should be replaced, this report sets forth very specific procedures for conducting a comprehensive inventory of monographic holdings. They are based on…

  20. Nutritional Problems and Policy in Tanzania. Cornell International Nutrition Monograph Series, Number 7 (1980).

    Science.gov (United States)

    Mgaza, Olyvia

    This monograph discusses policies designed to deal with food and nutrition problems in Tanzania. Available information on food supplies and nutritional conditions in Tanzania clearly shows that the country faces nutritional problems; protein energy malnutrition is the most serious and requires priority action. Iron deficiency anemia, goiter, and…

  1. Interactive Robotic Aids--One Option for Independent Living: An International Perspective. Monograph Number 37.

    Science.gov (United States)

    Foulds, Richard, Ed.

    The monograph is a collection of papers on the role of robotics in rehabilitation. The first four papers represent contributions from other countries: "Spartacus and Manus: Telethesis Developments in France and the Netherlands" (H. Kwee); "A Potential Application in Early Education and a Possible Role for a Vision System in a Workstation Based…

  2. The Taming of the Press in Sri Lanka. Journalism Monographs Number 39.

    Science.gov (United States)

    Gunaratne, Shelton A.

    This issue of "Journalism Monographs" deals specifically with the state of newspaper journalism in Sri Lanka, formerly the Dominion of Ceylon. The country's literacy rate is about 81 percent. The first section of this article is a general discussion of newspaper journalism in Sri Lanka, examining historical background and such press…

  3. Logo and Geometry. Journal for Research in Mathematics Education Monograph Series.

    Science.gov (United States)

    Clements, Douglas H.; Battista, Michael T.

    This book, the 10th volume in the Journal for Research in Mathematics Education (JRME) Monograph Series, discusses the geometry curriculum and investigates how elementary school students learn geometric concepts and how Logo programming and its turtle graphics might affect this learning. This volume also provides details on the development,…

  4. The evaluation of scientific monograph and publisher's role: the spanish project Scholarly Publishers Indicators (SPI

    Directory of Open Access Journals (Sweden)

    Andrea Capaccioni

    2016-05-01

    Full Text Available This paper aims to examine the issue about the quality assessment of scientific monograph and the role of publishers in the field of Humanities and Social Sciences, focusing on the Spanish project Scholarly Publishers Indicators (SPI. This project was born to identify and explore specific quality indicators for scientific books, starting from the opinion of SSH Spanish experts.

  5. Administration and Supervision for Safety in Sports. Sports Safety Series: Monograph No. 1.

    Science.gov (United States)

    Borozne, Joseph, Ed.; And Others

    Examined in this monograph are issues concerned with accident problems in sports. Materials are organized under eight headings, each developed by an expert in the area: (1) the injury problem in sports; (2) philosophy of sports accident prevention and injury control; (3) an introduction to administration and supervision; (4) administration and…

  6. Honors Programs at Smaller Colleges. 3rd Edition. National Collegiate Honors Council Monograph Series

    Science.gov (United States)

    Schuman, Samuel

    2011-01-01

    This monograph focuses upon areas of special concern to those working with honors at smaller colleges and universities: mission, recruitment, facilities, administration, budget, and curriculum. In each area, the author makes some general suggestions about overall operating principles, note specific issues that can lead to difficulties, and suggest…

  7. Data Matching, Integration, and Interoperability for a Metric Assessment of Monographs

    DEFF Research Database (Denmark)

    Zuccala, Alesia Ann; Cornacchia, Roberto

    2016-01-01

    This paper details a unique data experiment carried out at the University of Amsterdam, Center for Digital Humanities. Data pertaining to monographs were collected from three autonomous resources, the Scopus Journal Index, WorldCat.org and Goodreads, and linked according to unique identifiers...

  8. Employer Relations and Recruitment Services: An Essential Part of Postsecondary Career Services. Monograph Series

    Science.gov (United States)

    Hoover, Myrna P.; Lenz, Janet G.; Garis, Jeff

    2013-01-01

    This monograph is intended for any career services provider seeking a guide for developing employer relations and recruitment services at a postsecondary institution. It serves to inform readers about the changing meaning of "placement" over the years and the role it currently plays in career services. The publication describes…

  9. HPLC method validation for modernization of the tetracycline hydrochloride capsule USP monograph

    Directory of Open Access Journals (Sweden)

    Emad M. Hussien

    2014-12-01

    Full Text Available This paper is a continuation to our previous work aiming at development and validation of a reversed-phase HPLC for modernization of tetracycline-related USP monographs and the USP general chapter . Previous results showed that the method is accurate and precise for the assay of tetracycline hydrochloride and the limit of 4-epianhydrotetracycline impurity in the drug substance and oral suspension monographs. The aim of the current paper is to examine the feasibility of the method for modernization of USP tetracycline hydrochloride capsule monograph. Specificity, linearity, accuracy and precision were examined for tetracycline hydrochloride assay and 4-epianhydrotetracycline limit. The method was linear in the concentration range from 80% to 160% (r>0.9998 of the assay concentration (0.1 mg/mL for tetracycline hydrochloride and from 50% to 150% (r>0.997 of the acceptance criteria specified in tetracycline hydrochloride capsule monograph for 4-epianhydrotetracycline (NMT 3.0%. The recovery at three concentration levels for tetracycline hydrochloride assay was between 99% and 101% and the RSD from six preparations at the concentration 0.1 mg/mL is less than 0.6%. The recovery for 4-epianhydrotetracycline limit procedure over the concentration range from 50% to 150% is between 96% and 102% with RSD less than 5%. The results met the specified acceptance criteria.

  10. Does It Make a Sound: Are Open Access Monographs Discoverable in Library Catalogs?

    Science.gov (United States)

    McCollough, Aaron

    2017-01-01

    This article describes an exploratory study examining the common perception among library-based publishers that open access academic publications (especially monographs) are not readily discoverable in library catalogs. Using titles from the Michigan Publishing imprint, digital culture books, the study provides an empirical basis for evaluating…

  11. Does It Make a Sound: Are Open Access Monographs Discoverable in Library Catalogs?

    Science.gov (United States)

    McCollough, Aaron

    2017-01-01

    This article describes an exploratory study examining the common perception among library-based publishers that open access academic publications (especially monographs) are not readily discoverable in library catalogs. Using titles from the Michigan Publishing imprint, digital culture books, the study provides an empirical basis for evaluating…

  12. Cocaine: Pharmacology, Effects, and Treatment of Abuse. National Institute on Drug Abuse Research Monograph 50.

    Science.gov (United States)

    Grabowski, John, Ed.

    This monograph consists of eight papers which refer in one way or another to the pharmacology of cocaine. The papers are: (1) Cocaine 1984: Introduction and Overview" (John Grabowski); (2) "Cocaine: A Growing Public Health Problem" (Edgar H. Adams and Jack Durell); (3) "Neural Mechanisms of the Reinforcing Action of…

  13. Interwoven Lives: Adolescent Mothers and Their Children. Research Monographs in Adolescence.

    Science.gov (United States)

    Whitman, Thomas L.; Borkowski, John G.; Keogh, Deborah A.; Weed, Keri

    This monograph details the Notre Dame Parenting Project, a comprehensive longitudinal study of the lives of adolescent mothers and their children from pregnancy through the first 8 years of life, describing how their respective developmental trajectories are interwoven and linked to the social contexts in which they live. A total of 281…

  14. Education of the Handicapped and Its Implications for Elementary Industrial Arts. ACESIA Monograph 7.

    Science.gov (United States)

    Calder, Clarence R., Jr.; Horvath, Lester J.

    The purpose of this monograph is to illustrate the implications of Public Law 94-142 on public education at the state and local levels. The first section illustrates the importance for all educators to be aware of the administrative design used in this piece of permanent legislation. The second section describes the major provisions of Public Law…

  15. Employer Relations and Recruitment Services: An Essential Part of Postsecondary Career Services. Monograph Series

    Science.gov (United States)

    Hoover, Myrna P.; Lenz, Janet G.; Garis, Jeff

    2013-01-01

    This monograph is intended for any career services provider seeking a guide for developing employer relations and recruitment services at a postsecondary institution. It serves to inform readers about the changing meaning of "placement" over the years and the role it currently plays in career services. The publication describes…

  16. Making Industrial Education Facilities Accessible to the Physically Disabled. A Professional Monograph.

    Science.gov (United States)

    Shackelford, Ray; Henak, Richard

    This monograph focuses on the design of accessible industrial education facilities for individuals with physical disabilities. In chapter 1 accessibility is defined, and three significant pieces of federal legislation regarding the equality of educational opportunities for special needs populations are discussed. The role of industrial education…

  17. South Asian Nomads--A Literature Review. CREATE Pathways to Access. Research Monograph No. 58

    Science.gov (United States)

    Sharma, Anita

    2011-01-01

    This review of literature on South Asian nomads is part of a series of monographs on educational access published by the Consortium for Research on Educational Access Transitions and Equity (CREATE). In the context of India, most recent work has focused on access to the education system for the poor. CREATE research in India has focused on …

  18. News Piracy: Unfair Competition and the Misappropriation Doctrine. Journalism Monographs No. 56.

    Science.gov (United States)

    Sullivan, Paul W.

    Unfair competition is a complex problem affecting all areas of American business, including the communications media. Piracy of material, an alarmingly widespread example of unfair competition, involves legal as well as ethical questions. This monograph uses the historical approach to trace the development of common-law precedent and trends and…

  19. The Evaluation and Selection of Instructional Software for Use with the Learning Disabled. CREATE Monograph Series.

    Science.gov (United States)

    Weisgerber, Robert A.; Blake, Patricia L.

    Fourth in a series of six monographs on the use of new technologies in the instruction of learning disabled (LD) students, this paper explores issues related to the evaluation and selection of instructional software for LD students. Topics discussed include the following: (1) criteria for instructionally useful software (e.g., flexibility and…

  20. The Learning Disabled and Computer Based Education: Program Design Strategies. CREATE Monograph Series.

    Science.gov (United States)

    Rubin, David; And Others

    Third in a series of six monographs on the use of new technologies in the instruction of learning disabled students, the paper explores program design strategies for computer-based instructional materials. Section 1 summarizes ideas related to models of perception and cognition, theories of instruction, and key characteristics of intelligent…

  1. Optimal Approaches to Microcomputer Implementation in the Schools. [CREATS Monograph Series.

    Science.gov (United States)

    Bakke, Thomas W.

    Fifth in a series of six monographs on the use of new technologies in the instruction of learning disabled students, the paper describes how schools can plan for the acquisition of computer hardware and software, and how they can provide district-level staff training in its use. Discussion focuses on the development of a technology implementation…

  2. Modelling object typicality in description logics - [Workshop on Description Logics

    CSIR Research Space (South Africa)

    Britz, K

    2009-07-01

    Full Text Available The authors presents a semantic model of typicality of concept members in description logics that accords well with a binary, globalist cognitive model of class membership and typicality. The authors define a general preferential semantic framework...

  3. Screening assays for carcinogenic agents and mixtures: an appraisal based on data in the IARC Monograph series.

    Science.gov (United States)

    Bartsch, H; Malaveille, C

    1990-01-01

    To determine whether genotoxic and non-genotoxic carcinogens contribute similarly to the cancer burden in humans and which types of short-term test are more relevant for predicting human hazards, an analysis was performed on agents that were evaluated in IARC Monographs Supplements 6 and 7 for their carcinogenic effects in humans and animals and for activity in short-term genotoxicity tests. The prevalence of genotoxicity among four groups of agents, consisting of established human carcinogens (group 1, n = 30), probable human carcinogens (group 2A, n = 37), possible human carcinogens (group 2B, n = 113) and agents with limited evidence of carcinogenicity in animals (a subset of group 3, n = 66) was determined. Each of the groups 1, 2A and 2B contained a high proportion (80-90%) of genotoxic carcinogens, which were also multi-species or multi-tissue carcinogens. The distribution of carcinogenic potency in rodents did not reveal any specific characteristic of the human carcinogens in group 1 that would differentiate them from agents in groups 2A, 2B and many in group 3. Although limited by the data-base available through the Monographs series, this analysis implies that genotoxic carcinogens add more to the human cancer burden than non-genotoxic carcinogens. Thus, the continued use of in vitro/in vivo short-term tests, involving as endpoints DNA chromosomal or mutational damage, to identify genotoxic carcinogens or in the isolation of carcinogenic components in complex mixtures is fully justified. It is concluded that (a) an agent or complex mixture with unknown carcinogenic potential showing sufficient evidence of activity in genotoxicity assays in vitro or in vivo is likely to represent a hazard to humans and (b) an agent or complex mixture showing lack of activity in this spectrum of genotoxicity assays should undergo evaluation for carcinogenicity for rodent bioassay, in view of the present lack of validated short-term tests for non-genotoxic carcinogens.

  4. Biowaiver monographs for immediate release solid oral dosage forms based on biopharmaceutics classification system (BCS) literature data: verapamil hydrochloride, propranolol hydrochloride, and atenolol.

    Science.gov (United States)

    Vogelpoel, H; Welink, J; Amidon, G L; Junginger, H E; Midha, K K; Möller, H; Olling, M; Shah, V P; Barends, D M

    2004-08-01

    Literature data related to the Biopharmaceutics Classification System (BCS) are presented on verapamil hydrochloride, propranolol hydrochloride, and atenolol in the form of BCS-monographs. Data on the qualitative composition of immediate release (IR) tablets containing these active substances with a Marketing Authorization (MA) in the Netherlands (NL) are also provided; in view of these MA's the assumption was made that these tablets were bioequivalent to the innovator product. The development of a database with BCS-related data is announced by the International Pharmaceutical Federation (FIP).

  5. Man-made mineral (vitreous) fibres: evaluations of cancer hazards by the IARC Monographs Programme.

    Science.gov (United States)

    Baan, Robert A; Grosse, Yann

    2004-09-03

    Man-made vitreous (glass-like) fibres are non-crystalline, fibrous inorganic substances (silicates) made primarily from rock, slag, glass or other processed minerals. These materials, also called man-made mineral fibres, include glass fibres (used in glass wool and continuous glass filament), rock or stone wool, slag wool and refractory ceramic fibres. They are widely used for thermal and acoustical insulation and to a lesser extent for other purposes. These products are potentially hazardous to human health because they release airborne respirable fibres during their production, use and removal. Man-made mineral fibres and man-made vitreous fibres have been the subject of reviews by IARC Monographs Working Groups in 1987 and 2001, respectively, which resulted in evaluations of the carcinogenic hazard to humans from exposure to these materials. These reviews and evaluations have been published as Volumes 43 and 81 of the IARC Monographs series [IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 43, Man-made Mineral Fibres and Radon (1988); IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 81, Man-made Vitreous Fibres (2002)]. The re-evaluation in 2001 was undertaken because there have been substantial improvements in the quality of the epidemiological information available on the carcinogenicity to humans of glass fibres, continuous glass filament and rock/slag wool. The new evaluations have addressed the limitations of earlier cohort studies, particularly concerning the lack of adjustment with respect to concomitant risk factors such as smoking and other sources of occupational exposure. In addition, the evaluation of the evidence for carcinogenicity of glass fibres to experimental animals has been refined, by making a distinction between insulation glass wool and special-purpose glass fibres. The results of the evaluations in 1987 and 2001 are thus different in several aspects. In this paper, the reviews and evaluations

  6. A description of the global land-surface precipitation data products of the Global Precipitation Climatology Centre with sample applications including centennial (trend analysis from 1901–present

    Directory of Open Access Journals (Sweden)

    A. Becker

    2012-09-01

    Full Text Available The availability of highly accessible and reliable monthly gridded data sets of the global land-surface precipitation is a need that has already been identified in the mid-80s when there was a complete lack of a globally homogeneous gauge based precipitation analysis. Since 1989 the Global Precipitation Climatology Centre (GPCC has built up a unique capacity to assemble, quality assure, and analyse rain gauge data gathered from all over the world. The resulting data base has exceeded 200 yr in temporal coverage and has acquired data from more than 85 000 stations world-wide. This paper provides the reference publication for the four globally gridded monthly precipitation products of the GPCC covering a 111-yr analysis period from 1901–present, processed from this data base. As required for a reference publication, the content of the product portfolio, as well as the underlying methodologies to process and interpolate are detailed. Moreover, we provide information on the systematic and statistical errors associated with the data products. Finally, sample applications provide potential users of GPCC data products with suitable advice on capabilities and constraints of the gridded data sets. In doing so, the capabilities to access ENSO and NAO sensitive precipitation regions and to perform trend analysis across the past 110 yr are demonstrated. The four gridded products, i.e. the Climatology V2011 (CLIM, the Full Data Reanalysis (FD V6, the Monitoring Product (MP V4, and the First Guess Product (FG are public available on easy accessible latitude longitude grids encoded in zipped clear text ASCII files for subsequent visualization and download through the GPCC download gate hosted on ftp://ftp.dwd.de/pub/data/gpcc/html/download_gate.html by the Deutscher Wetterdienst (DWD, Offenbach, Germany. Depending on the product four (0.25°, 0.5°, 1.0°, 2.5° for CLIM

  7. Quantum mechanical description of waveguides

    Institute of Scientific and Technical Information of China (English)

    Wang Zhi-Yong; Xiong Cai-Dong; He Bing

    2008-01-01

    Applying the spinor representation of the electromagnetic field,this paper present a quantum-mechanical description of waveguides.As an example of application,a potential qubit generated by photon tunnelling is discussed.

  8. Biowaiver monographs for immediate release solid oral dosage forms: amodiaquine hydrochloride.

    Science.gov (United States)

    Nair, Anita; Abrahamsson, Bertil; Barends, Dirk M; Groot, D W; Kopp, Sabine; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2012-12-01

    The present monograph reviews data relevant to applying the biowaiver procedure for the approval of immediate release (IR) multisource solid dosage forms containing amodiaquine hydrochloride (ADQ) as the single active pharmaceutical ingredient (API). Both biopharmaceutical and clinical data of ADQ were assessed. Solubility studies revealed that ADQ meets the "highly soluble" criteria according to World Health Organization (WHO) and European Medicines Agency (EMA) but fails to comply with the United States Food and Drug Administration (US FDA) specifications. Although metabolism hints at high permeability, available permeability data are too scanty to classify ADQ inequivocably as a Class I drug substance. According to WHO and EMA guidances, ADQ would be conservatively categorized as a Class III drug, whereas according to the US FDA specifications, it would fall into Class IV. ADQ has a wide therapeutic index. Furthermore, no cases of bioinequivalent products have been reported in the open literature. As risks associated with biowaiving appear minimal and requirements for "highly soluble" API are met in the WHO and EMA jurisdictions, the biowaiver procedure can be recommended for bioequivalence (BE) testing of multisource IR products containing ADQ as the only API, provided the test product contains excipients used in ADQ products approved in International Conference of Harmonisation and associated countries, and in similar amounts. Furthermore, both comparator and test should conform to "very rapidly dissolving" product criteria (≥85% dissolution of the API in 15 min at pH 1.2, 4.5, and 6.8) and the labeling should specify that the product not be coadministered with high-fat meals. If the comparator and/or test product fails to meet these criteria, BE needs to be established by pharmacokinetic studies in humans.

  9. Prevalence of genotoxic chemicals among animal and human carcinogens evaluated in the IARC Monograph Series.

    Science.gov (United States)

    Bartsch, H; Malaveille, C

    1989-06-01

    To determine whether genotoxic and non-genotoxic carcinogens contribute similarly to the cancer burden in humans, an analysis was performed on agents that were evaluated in Supplements 6 and 7 to the IARC Monographs for their carcinogenic effects in humans and animals and for the activity in short-term genotoxicity tests. The prevalence of genotoxic carcinogens on four groups of agents, consisting of established human carcinogens (group 1, n = 30), probable human carcinogens (group 2A, n = 37), possible human carcinogens (group 2B, n = 113) and on agents with limited evidence of carcinogenicity in animals (a subset of group 3, n = 149) was determined. A high prevalence in the order of 80 to 90% of genotoxic carcinogens was found in each of the groups 1, 2A and 2B, which were also shown to be multi-species/multi-tissues carcinogens. The distribution of carcinogenic potency in rodents did not reveal any specific characteristic of the human carcinogens in group 1 that would differentiate them from agents in groups 2A, 2B and 3. The results of this analysis indicate that (a) an agent with unknown carcinogenic potential showing sufficient evidence of activity in in vitro/in vivo genotoxicity assays (involving as endpoints DNA damage and chromosomal/mutational damage) may represent a hazard to humans; and b) an agent showing lack of activity in this spectrum of genotoxicity assays should undergo evaluation for carcinogenicity by rodent bioassay, in view of the present lack of validated short-term tests for non-genotoxic carcinogens. Overall, this analysis implies that genotoxic carcinogens add more to the cancer burden in man than non-genotoxic carcinogens. Thus, identification of such genotoxic carcinogens and subsequent lowering of exposure will remain the main goal for primary cancer prevention in man.

  10. A royal description of madness.

    Science.gov (United States)

    Ottilingam, Somasundaram; Tejus, Murthy; Vijaya, Raghavan

    2016-08-01

    The search for the description of mental illness in the community is an interesting pastime and has been attempted by many psychiatrists. The present writer has described an instance in the Tamil literature of the 2nd century CE in the Tamil Buddhist epic, Manimekalai. Presently, is given another description from the stylus of the Tamil Pallava king, Mahendravarman of the 6th century CE from his farcical drama of Mattavilasa Prahasana. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Multidimensional nonlinear descriptive analysis

    CERN Document Server

    Nishisato, Shizuhiko

    2006-01-01

    Quantification of categorical, or non-numerical, data is a problem that scientists face across a wide range of disciplines. Exploring data analysis in various areas of research, such as the social sciences and biology, Multidimensional Nonlinear Descriptive Analysis presents methods for analyzing categorical data that are not necessarily sampled randomly from a normal population and often involve nonlinear relations. This reference not only provides an overview of multidimensional nonlinear descriptive analysis (MUNDA) of discrete data, it also offers new results in a variety of fields. The first part of the book covers conceptual and technical preliminaries needed to understand the data analysis in subsequent chapters. The next two parts contain applications of MUNDA to diverse data types, with each chapter devoted to one type of categorical data, a brief historical comment, and basic skills peculiar to the data types. The final part examines several problems and then concludes with suggestions for futu...

  12. Multiple descriptions based wavelet image coding

    Institute of Scientific and Technical Information of China (English)

    陈海林; 杨宇航

    2004-01-01

    We present a simple and efficient scheme that combines multiple descriptions coding with wavelet transform under JPEG2000 image coding architecture. To reduce packet losses, controlled amounts of redundancy are added to the wavelet transform coefficients to produce multiple descriptions of wavelet coefficients during the compression process to produce multiple descriptions bit-stream of a compressed image. Even if areceiver gets only parts of descriptions (other descriptions being lost), it can still reconstruct image with acceptable quality. Specifically, the scheme uses not only high-performance wavelet transform to improve compression efficiency, but also multiple descriptions technique to enhance the robustness of the compressed image that is transmitted through unreliable network channels.

  13. Management control system description

    Energy Technology Data Exchange (ETDEWEB)

    Bence, P. J.

    1990-10-01

    This Management Control System (MCS) description describes the processes used to manage the cost and schedule of work performed by Westinghouse Hanford Company (Westinghouse Hanford) for the US Department of Energy, Richland Operations Office (DOE-RL), Richland, Washington. Westinghouse Hanford will maintain and use formal cost and schedule management control systems, as presented in this document, in performing work for the DOE-RL. This MCS description is a controlled document and will be modified or updated as required. This document must be approved by the DOE-RL; thereafter, any significant change will require DOE-RL concurrence. Westinghouse Hanford is the DOE-RL operations and engineering contractor at the Hanford Site. Activities associated with this contract (DE-AC06-87RL10930) include operating existing plant facilities, managing defined projects and programs, and planning future enhancements. This document is designed to comply with Section I-13 of the contract by providing a description of Westinghouse Hanford's cost and schedule control systems used in managing the above activities. 5 refs., 22 figs., 1 tab.

  14. Review for the volume Alexei Marco. The destiny of a jeweler from Moldova, by Liliana Condraticova, work about the monographic study of the artist jeweler Alexei Marco, within Moldovan cultural space

    Directory of Open Access Journals (Sweden)

    Ana CARAS

    2012-06-01

    Full Text Available The present paper represents the review for the volume Alexei Marco. The destiny of a jeweler from Moldova, by Liliana Condraticova, published at Lumen Publishing House, a volume about the monographic study of an artist jeweler from Moldova. The work comes as a novelty element in the cultural context of Moldova. The lack of studies regarding the life and work of the masters of jewelry manufacturing, determined the author to develop a work in order to provide relevant, comprehensive information, in terms of the artistic creation of the most famous jeweler in Moldova – Alexei Marco. The study uses monographic method, a method used particularly in empirical research, which involves direct observation of territorial social unit without the use of sampling and without manipulating variables. The social reality investigated is approached in all its manifestations.

  15. The Development of Monograph with 3-Dimentional Illustrations Titled “Augmented Chemistry: Hydrocarbon” as Learning Enrichment Materials

    Science.gov (United States)

    Ernawati, D.; Ikhsan, J.

    2017-02-01

    The development of 3D technology provides more advantages in education sectors. In chemistry, the 3D technology makes chemistry objects look more tangible. This research developed a monograph titled “Augmented Chemistry: Hydrocarbon” as learning enrichment materials. The development model consisted of 5 steps, which were the adaptation of the ADDIE model. The 3D objects of chemistry were built using the computer applications of Chem Sketch, and Google Sketch Up with AR Plugin. The 3D objects were displayed by relevant markers on the texts of the monograph from which the visualizations of the 3D objects appeared when they were captured by digital camera of laptop or smartphone, and were possibly viewed with free-rotation. Not only were 3D chemistry objects included in the monograph, but also graphics, videos, audios, and animations, which facilitated more fun learning for readers of the monograph. After the reviews by the experts of subject matter, of media, of instruction, and by peers, the monograph was revised, and then rated by chemistry teachers. The analysis of the data showed that the monograph titled “Augmented Chemistry: Hydrocarbon” was in the criteria of very good for the enrichment materials of Chemistry learning.

  16. Arrangement and processing of monographic publications in youth sections of public libraries

    Directory of Open Access Journals (Sweden)

    Mateja Ločniškar-Fidler

    2006-01-01

    Full Text Available A systematic and transparent layout of library material on book shelves of public libraries is one of the essential conditions for successful viewing and searching of materials. The research tried to determine the contemporary classification system of library material for the youth. The data needed for the research was gathered and analyzed by a questionnaire completed by five randomly selected central public libraries. Special collections, arrangement and classification of certain fiction and specialized monographic publications for infants, teenagers and adolescents were analyzed. It was of our interest to observe whether the libraries assign the elements of a call number - which are evident on the library material and in online catalogs – according to standards and current instructions. The article also focuses on the unity and differences of the technical processing, and on color and/or image of labels which additionally explain the classification and the contents of the monographic publications for the youth.

  17. The UNO Aviation Monograph Series: Aviation Security: An Annotated Bibliography of Responses to the Gore Commission

    Science.gov (United States)

    Carrico, John S.; Schaaf, Michaela M.

    1998-01-01

    This monograph is a companion to UNOAI Monograph 96-2, "The Image of Airport Security: An Annotated Bibliography," compiled in June 1996. The White House Commission on Aviation Safety and Security, headed by Vice President Al Gore, was formed as a result of the TWA Flight 800 crash in August 1996. The Commission's final report included 31 recommendations addressed toward aviation security. The recommendations were cause for security issues to be revisited in the media and by the aviation industry. These developments necessitated the need for an updated bibliography to review the resulting literature. Many of the articles were written in response to the recommendations made by the Gore Commission. "Aviation Security: An Annotated Bibliography of Responses to the Gore Commission" is the result of this need.

  18. Description logic rules

    CERN Document Server

    Krötzsch, M

    2010-01-01

    Ontological modelling today is applied in many areas of science and technology,including the Semantic Web. The W3C standard OWL defines one of the most important ontology languages based on the semantics of description logics. An alternative is to use rule languages in knowledge modelling, as proposed in the W3C's RIF standard. So far, it has often been unclear how to combine both technologies without sacrificing essential computational properties. This book explains this problem and presents new solutions that have recently been proposed. Extensive introductory chapters provide the necessary

  19. Truth, Perception, and Consequences (Proteus Monograph Series, Volume 1, Issue 1, November 2007)

    Science.gov (United States)

    2007-11-01

    TruTh , PercePTion, and consequences The Proteus Monograph Series Volume 1, Issue 1 November 2007 Report Documentation Page Form ApprovedOMB No. 0704...2007 to 00-00-2007 4. TITLE AND SUBTITLE Truth , Perception, and Consequences 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...Intelligence, or the U.S. Government. This report is cleared for public release; distribution is unlimited. TruTh , PercePTion, and consequences by

  20. Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction.

    Science.gov (United States)

    Basalo, Carlos; Mohn, Tobias; Hamburger, Matthias

    2006-10-01

    The extraction methods in selected monographs of the European and the Swiss Pharmacopoeia were compared to pressurized liquid extraction (PLE) with respect to the yield of constituents to be dosed in the quantitative assay for the respective herbal drugs. The study included five drugs, Belladonnae folium, Colae semen, Boldo folium, Tanaceti herba and Agni casti fructus. They were selected to cover different classes of compounds to be analyzed and different extraction methods to be used according to the monographs. Extraction protocols for PLE were optimized by varying the solvents and number of extraction cycles. In PLE, yields > 97 % of extractable analytes were typically achieved with two extraction cycles. For alkaloid-containing drugs, the addition of ammonia prior to extraction significantly increased the yield and reduced the number of extraction cycles required for exhaustive extraction. PLE was in all cases superior to the extraction protocol of the pharmacopoeia monographs (taken as 100 %), with differences ranging from 108 % in case of parthenolide in Tanaceti herba to 343 % in case of alkaloids in Boldo folium.

  1. Taxonomic revision of Elaphoglossum subsection Muscosa (Dryopteridaceae)

    NARCIS (Netherlands)

    Vasco, A.

    2011-01-01

    The present paper provides a monograph of Elaphoglossum subsect. Muscosa, a monophyletic group supported by molecular phylogenetic analyses. The monograph includes keys, full synonymy, descriptions, representative specimens examined, an index to collectors’ names and numbers, illustrations, spore

  2. Guidelines for Description

    NARCIS (Netherlands)

    Links, P.; Horsman, Peter; Kühnel, Karsten; Priddy, M.; Reijnhoudt, Linda; Merenmies, Mark

    2013-01-01

    The Guidelines follow the conceptual metadata model (deliverable 17.2). They include guidelines for description of collection-holding institutions, document collections, organisations, personalities, events, camps and ghettos. As much as possible the guidelines comply with the descriptive standards

  3. Workshop Presentations of the World Seminar on Employment Counseling (Ottawa, Ontario, September 1980).

    Science.gov (United States)

    Ross, Gladys G., Ed.

    This monograph presents 26 papers addressed to workshop sessions representing thought and innovation in employment counseling and vocational guidance. Two papers are written in German, one in French, and 23 in English. Abstracts preceding each paper appear in the two languages other than that used for the paper itself. Topics covered include…

  4. A monograph of the freshwater Bryozoa-Phylactolaemata

    NARCIS (Netherlands)

    Lacourt, A.W.

    1968-01-01

    1. This paper presents the taxonomy of the Bryozoa Phylactolaemata. The group is found to contain a number of series. The present classification reveals that a number of specific names are synonyms. 2. The evolution of the group is described on the basis of the development of the zoarium and the

  5. The initial management of stable angina in Europe, from the Euro Heart Survey: a description of pharmacological management and revascularization strategies initiated within the first month of presentation to a cardiologist in the Euro Heart Survey of Stable Angina.

    NARCIS (Netherlands)

    Daly, C.A.; Clemens, F.; Lopez-Sendon, J.; Tavazzi, L.; Boersma, E.; Danchin, N.; Delahaye, F.; Gitt, A.; Julian, D.; Mulcahy, D.; Ruzyllo, W.; Thygesen, K.; Verheugt, F.W.A.; Fox, K.M.

    2005-01-01

    AIMS: In order to assess adherence to guidelines and international variability in management, the Euro Heart Survey of Newly Presenting Angina prospectively studied medical therapy, percutaneous coronary intervention (PCI), and surgery in patients with new-onset stable angina in Europe. METHODS AND

  6. Archival description: a conceptual discussion

    Directory of Open Access Journals (Sweden)

    Luciane Paula Vital

    2016-04-01

    Full Text Available Introduction: Contextualizes the activity of archival description in the processes of organization and representation of information. Objective: Features aimed at identifying the concept of archival description presented in scientific articles of Information Science. Methodology: It is a literature that employs techniques of content analysis. 9 examines scientific articles recovered Base Reference Data Journal Articles in Information Science (BRAPCI and International Basis Library and Information Science Abstracts (LISA, that meet the criteria. Results: Considers the concept of archival description in the literature of information science considered a form of representation of information through a process of analyzing, organizing and recording information. Information is represented by structure elements (support and means of access and elements of content and context. Conclusions: Highlights the paucity of studies that present a theoretical discussion about the theme and possible approaches to the areas of organization and representation of information.

  7. Auteur Description: From the Director's Creative Vision to Audio Description

    Science.gov (United States)

    Szarkowska, Agnieszka

    2013-01-01

    In this report, the author follows the suggestion that a film director's creative vision should be incorporated into Audio description (AD), a major technique for making films, theater performances, operas, and other events accessible to people who are blind or have low vision. The author presents a new type of AD for auteur and artistic films:…

  8. Heparin sodium compliance to USP monograph: structural elucidation of an atypical 2.18 ppm NMR signal.

    Science.gov (United States)

    Mourier, Pierre A J; Guichard, Olivier Y; Herman, Fréderic; Viskov, Christian

    2012-01-01

    The ¹H nuclear magnetic resonance (NMR) acceptance criteria in the new heparin US Pharmacopeia (USP) monograph do not take into account potential structural modifications responsible for any extra signals observed in ¹H NMR spectra, some purified heparins may be non-compliant under the proposed new USP guidelines and incorrectly classified as unsuitable for pharmaceutical use. Heparins from the "ES" source, containing an extra signal at 2.18 ppm, were depolymerized under controlled conditions using heparinases I, II, and III. The oligosaccharides responsible for the 2.18 ppm signal were enriched using orthogonal chromatographic techniques. After multiple purification steps, we obtained an oligosaccharide mixture containing a highly enriched octasaccharide bearing the structural modification responsible for the extra signal. Following heparinase I depolymerization, a pure tetrasaccharide containing the fingerprint structural modification was isolated for full structural determination. Using 1D and 2D ¹H NMR spectroscopy, the structural moiety responsible for the extra signal at 2.18 ppm was identified as an acetyl group on the heparin backbone, most likely resulting from a very minor manufacturing process side reaction that esterifies the uronic acid at position 3. Such analytical peculiarity has always been present in this heparin source and it was used safety over the years. Copyright © 2012 Elsevier B.V. All rights reserved.

  9. Veterinary History Museum in Zagreb - on the occasion of a jubilee monograph on the collection of veterinary instruments of the Zagreb University Faculty of Medicine.

    Science.gov (United States)

    Vucevac Bajt, Vesna

    2010-01-01

    To mark its 90th anniversary, the Faculty of Veterinary Medicine, University of Zagreb, published a book Collection of Veterinary Instruments from the Museum of Veterinary History, which is a significant contribution to the history of veterinary medicine of Croatia. The presented collection is on display in the Museum of Veterinary History at the Faculty of Veterinary Medicine. The Museum, an integral part of the Department of History of Veterinary Medicine, was founded by decree in 1936. It houses several collections: archives, veterinary and related literature, a collection of veterinary instruments, and a collection of horseshoes. The monograph presents the veterinary instruments which were of utmost importance for the development of veterinary science and practice.

  10. Symmetrical gait descriptions

    Science.gov (United States)

    Dunajewski, Adam; Dusza, Jacek J.; Rosado Muñoz, Alfredo

    2014-11-01

    The article presents a proposal for the description of human gait as a periodic and symmetric process. Firstly, the data for researches was obtained in the Laboratory of Group SATI in the School of Engineering of University of Valencia. Then, the periodical model - Mean Double Step (MDS) was made. Finally, on the basis of MDS, the symmetrical models - Left Mean Double Step and Right Mean Double Step (LMDS and RMDS) could be created. The method of various functional extensions was used. Symmetrical gait models can be used to calculate the coefficients of asymmetry at any time or phase of the gait. In this way it is possible to create asymmetry, function which better describes human gait dysfunction. The paper also describes an algorithm for calculating symmetric models, and shows exemplary results based on the experimental data.

  11. Description of the effort sharing approaches as presented in the Ecofys' policy brief The next step in Europe's climate action. Setting targets for 2030

    Energy Technology Data Exchange (ETDEWEB)

    Hoehne, N.; Hagemann, M.; Fekete, H. [Ecofys, Utrecht (Netherlands)

    2013-06-15

    The paper 'The next step in Europe's climate action. Setting targets for 2030' explains how setting 2030 targets will reinvigorate the ETS and will put EU emissions on track to limit global temperature increase below two degrees Celsius (2C). The paper describes four key findings for EU policymakers engaged in preparing EU energy and climate measures for 2030 and for the longer term. This document aims to provide background information on the effort sharing approaches, as presented in fore-mentioned paper.

  12. Values, Inquiry, and Education. CSE Monograph Series in Evaluation, 9.

    Science.gov (United States)

    Gideonse, Hendrik, Ed.; And Others

    This edited volume contains 16 social science-related educational research articles based on papers presented at the 1979 annual meeting of the American Educational Research Association (AERA). The articles and associated commentary are organized according to six symposia held at the meeting--anthropology, evaluation, history, political science,…

  13. Le monde du theatre: monographie relative au montage d'une piece de theatre (The World of Theater: Monograph on Mounting a Theatrical Production).

    Science.gov (United States)

    Bokor, Pierre

    This monograph (in French) provides Alberta teachers with information relating to teaching about the world of the theater, and discusses the principal elements to be considered in mounting a theatrical production. It is intended for French language dramatic arts teachers (both in immersion courses and French-speaking schools). The monograph's four…

  14. Videoradiography of patients with habitual snoring and/or sleep apnea. Technical description and presentation of videoradiographic results during sleep concerning occurrence of apnea, type of apnea, and site of obstruction

    Energy Technology Data Exchange (ETDEWEB)

    Hillarp, B. [Dept. of Diagnostic Radiology, Malmoe Univ. Hospital (Sweden); Nylander, G. [Dept. of Diagnostic Radiology, Malmoe Univ. Hospital (Sweden); Rosen, I. [Dept. of Neurophysiology, Malmoe Univ. Hospital (Sweden); Wickstroem, O. [Dept. of Neurophysiology, Malmoe Univ. Hospital (Sweden)

    1995-05-01

    The videoradiographic examination described was designed for habitual snorers and sleep apnea syndrome (SAS) patients and was performed during wakefulness and sleep. During wakefulness the purpose was to reveal any dysfunction in deglutiton and speech as well as morphologic abnormalities. The purpose during sleep, which usually was induced by low-dose midazolam intravenously, was to reveal the site and form of obstruction in obstructive sleep apnea patients and the site of snoring in habitual snorers. The preoperative results of 104 patients are presented. In 57 patients who had apneas, the occurrence and type of apnea could be determined. A continuous recording over some minutes gave a rough estimate of the degree of SAS and mean duration of apnea. Although much information on SAS can be obtained by this method, it cannot replace polygraphic sleep recording in the investigation of habitual snorers and SAS patients. However, these 2 methods are complementary and can be performed simultaneously as polygraphic videoradiography. (orig.).

  15. Turbulent Dissipation Challenge -- Problem Description

    CERN Document Server

    Parashar, Tulasi N; Wicks, Robert; Karimabadi, Homa; Chandran, S Peter Gary Benjamin; Matthaeus, William H

    2014-01-01

    The goal of this document is to present a detailed description of the goals, simulation setup and diagnostics for the Turbulent Dissipation Challenge $($http://arxiv.org/abs/1303.0204$)$ as discussed in the Solar Heliospheric and INterplanetary Environment $($SHINE$)$ 2013 workshop, American Geophysical Union Fall Meeting 2013 and the accompanying antenna meeting in Berkeley.

  16. NTP Monograph: Developmental Effects and Pregnancy Outcomes Associated With Cancer Chemotherapy Use During Pregnancy.

    Science.gov (United States)

    2013-05-01

    The National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) conducted an evaluation of the developmental effects and pregnancy outcomes associated with cancer chemotherapy use during pregnancy in humans. The final NTP monograph was completed in May 2013 (available at http:// ntp.niehs.nih.gov/go/36495). The incidence of cancer during pregnancy has been reported to occur from 17 to 100 per 100,000 pregnant women. Chemotherapy is a common treatment for cancer; however, most chemotherapy agents are classified as known or suspected human teratogens. Cancer chemotherapy use during pregnancy was selected for evaluation by the NTP because of the: (1) paucity of comprehensive reviews on the pregnancy outcomes following cancer chemotherapy use during pregnancy in humans, including the integration of the developmental animal toxicology literature with the observational studies in humans, and (2) growing public interest in the developmental effects of chemotherapy on offspring exposed to cancer chemotherapy during gestation due to the expected incidence of cancer diagnosed during pregnancy as women delay pregnancy to later ages. Of the approximately 110 cancer chemotherapeutic agents currently in use, the NTP monograph includes data on 56 agents used during 1,261 pregnancies for which pregnancy outcomes were documented. Overall, the NTP evaluation found that treatment with chemotherapy for cancer appeared to be associated with: (1) a higher rate of major malformations following exposure during the first trimester compared to exposure in the second and/or third trimester; (2) an increase the rate of stillbirth following exposure in the second and/ or third trimester; abnormally low levels of amniotic fluid (primarily attributable to Trastuzumab); and (3), also data are insufficient, impaired fetal growth and myelosuppression. Treatment with chemotherapy for cancer during pregnancy did not appear to increase spontaneous preterm birth, or impair

  17. Monograph support provided by the National Library of Medicine and its regional medical libraries in the medical behavioral sciences.

    Science.gov (United States)

    Saye, J D; Griffith, B C

    1988-01-01

    The National Library of Medicine's (NLM) monographic resources in the medical behavioral sciences (MBS) were examined to assess NLM's ability to support the needs of researchers writing in this area. A sample of 239 representative monographs derived from citations in MBS-related articles published in 61 journals in 1981 were evaluated. These monographs were limited to works published between 1978 and 1981, inclusive. The subject distribution of the sample included fourteen of the twenty-one main classes in the LC classification, although BF (psychology), H (social sciences), and R (medicine) constituted 80.3% of the sample. The study revealed that NLM held 48.5% of the sample. The holdings of ten research medical libraries, including six of the seven regional medical libraries, were also evaluated in order to gauge NLM's ability to support that element of the medical library network. The holding rates of these libraries ranged widely (9.6% to 36%), although NLM was found to have far more extensive holdings overall, and when assessed against classes BF, H, and R. Overall, NLM could have supplied from 28.8% to 44.5% of the monographs not held by the medical libraries. In only a few cases were the ten medical libraries able to provide access to monographs not held by NLM. The findings of the study indicate that, regardless of NLM's indication of support to the MBS area, the holdings of more general research and academic libraries are essential to support the monograph needs of MBS researchers. PMID:3224221

  18. Mathematical description of the heat transfer in living tissue, 1 addendum

    CERN Document Server

    Lubashevsky, I A

    1999-01-01

    In the present monograph we formulate a simple model for heat transfer in living tissue with self - regulation. The initial point of the model is the governing equations describing heat transfer in living tissue at the mesoscopic level, i.e. considering different vessels individually. Then, basing on the well known equivalence of the diffusion type process and random walks, we develop a certain regular procedure that enables us to average these mesoscopic equations practically over all scales of the hierarchical vascular network. The microscopic governing equations obtained in this way describe living tissue in terms of an active medium with continuously distributed self - regulation. One of the interesting results obtained in the present monograph is that there can be the phenomena of ideal self - regulation in large active hierarchical systems. Large hierarchical systems are characterized by such a great information flow that none of its elements can possess whole information required of governing the syste...

  19. Chemical Vapor Deposited Zinc Sulfide. SPIE Press Monograph

    Energy Technology Data Exchange (ETDEWEB)

    McCloy, John S.; Tustison, Randal W.

    2013-04-22

    Zinc sulfide has shown unequaled utility for infrared windows that require a combination of long-wavelength infrared transparency, mechanical durability, and elevated-temperature performance. This book reviews the physical properties of chemical vapor deposited ZnS and their relationship to the CVD process that produced them. An in-depth look at the material microstructure is included, along with a discussion of the material's optical properties. Finally, because the CVD process itself is central to the development of this material, a brief history is presented.

  20. Biowaiver monographs for immediate release solid oral dosage forms: aciclovir.

    Science.gov (United States)

    Arnal, J; Gonzalez-Alvarez, I; Bermejo, M; Amidon, G L; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2008-12-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing (biowaiver) for the approval of immediate release (IR) solid oral dosage forms containing aciclovir are reviewed. Aciclovir therapeutic use and therapeutic index, pharmacokinetic properties, data related to the possibility of excipient interactions and reported BE/bioavailability (BA) studies were also taken into consideration in order to ascertain whether a biowaiver can be recommended. According to the Biopharmaceutics Classification System (BCS) and considering tablet strengths up to 400 mg, aciclovir would be BCS Class III. However, in some countries also 800 mg tablets are available which fall just within BCS Class IV. Aciclovir seems not to be critical with respect to a risk for bioinequivalence, as no examples of bioinequivalence have been identified. It has a wide therapeutic index and is not used for critical indications. Hence, if: (a) the test product contains only excipients present in aciclovir solid oral IR drug products approved in ICH or associated countries, for instance as presented in this article; and (b) the comparator and the test product both are very rapidly dissolving, a biowaiver for IR aciclovir solid oral drug products is considered justified for all tablet strengths.

  1. Biowaiver monographs for immediate release solid oral dosage forms: pyrazinamide.

    Science.gov (United States)

    Becker, C; Dressman, J B; Amidon, G L; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2008-09-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing pyrazinamide as the only active pharmaceutical ingredient (API) are reviewed. Pyrazinamide is BCS Class III, with linear absorption over a wide dosing range. The risk of bioinequivalence is estimated to be low. Depending on the definition used, pyrazinamide can be classified as a narrow therapeutic index (NTI) drug, which is usually a caveat to biowaiving but may be deemed acceptable if the Summary of Product Characteristics (SmPCs) of the test product stipulates the need for regular monitoring of liver function. It is concluded that a biowaiver can be recommended for IR solid oral dosage only when the test product (a) contains only excipients present in pyrazinamide IR solid oral drug products approved in ICH or associated countries, (b) these excipients are present in amounts normally used in IR solid oral dosage forms, (c) the test product is very rapidly dissolving, (d) the SmPC of the test product indicates the need for monitoring of the patient's liver function.

  2. YUCCA MOUNTAIN SITE DESCRIPTION

    Energy Technology Data Exchange (ETDEWEB)

    A.M. Simmons

    2004-04-16

    The ''Yucca Mountain Site Description'' summarizes, in a single document, the current state of knowledge and understanding of the natural system at Yucca Mountain. It describes the geology; geochemistry; past, present, and projected future climate; regional hydrologic system; and flow and transport within the unsaturated and saturated zones at the site. In addition, it discusses factors affecting radionuclide transport, the effect of thermal loading on the natural system, and tectonic hazards. The ''Yucca Mountain Site Description'' is broad in nature. It summarizes investigations carried out as part of the Yucca Mountain Project since 1988, but it also includes work done at the site in earlier years, as well as studies performed by others. The document has been prepared under the Office of Civilian Radioactive Waste Management quality assurance program for the Yucca Mountain Project. Yucca Mountain is located in Nye County in southern Nevada. The site lies in the north-central part of the Basin and Range physiographic province, within the northernmost subprovince commonly referred to as the Great Basin. The basin and range physiography reflects the extensional tectonic regime that has affected the region during the middle and late Cenozoic Era. Yucca Mountain was initially selected for characterization, in part, because of its thick unsaturated zone, its arid to semiarid climate, and the existence of a rock type that would support excavation of stable openings. In 1987, the United States Congress directed that Yucca Mountain be the only site characterized to evaluate its suitability for development of a geologic repository for high-level radioactive waste and spent nuclear fuel.

  3. Biowaiver monographs for immediate release solid oral dosage forms: prednisone.

    Science.gov (United States)

    Vogt, M; Derendorf, H; Krämer, J; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2007-06-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing prednisone are reviewed. Due to insufficient data prednisone cannot be definitively classified according to the current Biopharmaceutics Classification System (BCS) criteria as both the solubility and the permeability of prednisone are on the borderline of the present criteria of BCS Class I. Prednisone's therapeutic indications and therapeutic index, pharmacokinetics and the possibility of excipient interactions were also taken into consideration. Available evidence indicates that a biowaiver for IR solid oral dosage forms formulated with the excipients tabulated in this article would be unlikely to expose patients to undue risks.

  4. Biowaiver monographs for immediate release solid oral dosage forms: piroxicam.

    Science.gov (United States)

    Shohin, Igor E; Kulinich, Julia I; Ramenskaya, Galina V; Abrahamsson, Bertil; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Groot, D W; Barends, Dirk M; Dressman, Jennifer B

    2014-02-01

    Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing piroxicam in the free acid form are reviewed. Piroxicam solubility and permeability, its therapeutic use and therapeutic index, pharmacokinetic properties, data related to the possibility of excipient interactions and reported BE/bioavailability (BA), and corresponding dissolution data are taken into consideration. The available data suggest that according to the current biopharmaceutics classification system (BCS) and all current guidances, piroxicam would be assigned to BCS Class II. The extent of piroxicam absorption seems not to depend on manufacturing conditions or excipients, so the risk of bioinequivalence in terms of area under the curve (AUC) is very low, but the rate of absorption (i.e., BE in terms of Cmax ) can be affected by the formulation. Current in vitro dissolution methods may not always reflect differences in terms of Cmax for BCS Class II weak acids; however, minor differences in absorption rate of piroxicam would not subject the patient to unacceptable risks: as piroxicam products may be taken before or after meals, the rate of absorption cannot be considered crucial to drug action. Therefore, a biowaiver for IR piroxicam solid oral dosage form is considered feasible, provided that (a) the test product contains only excipients, which are also present in IR solid oral drug products containing piroxicam, which have been approved in ICH or associated countries, for instance, those presented in Table 3 of this paper; (b) both the test and comparator drug products dissolve 85% in 30 min or less at pH 1.2, 4.5, and 6.8; and (c) the test product and comparator show dissolution profile similarity in pH 1.2, 4.5, and 6.8. When not all of these conditions can be fulfilled, BE of the products should be established in vivo.

  5. Freud's private mini-monograph on his own dreams. A contribution to the celebration of the centenary of The interpretation of dreams.

    Science.gov (United States)

    Blum, H P

    2001-10-01

    A virtually unknown brief commentary by Freud on the characteristics of his own dreams is described and discussed. Freud's mini-monograph, discovered after some 80 years, has autobiographical, theoretical and organisational significance in the enigmatic context of the early development of psychoanalysis. Found among papers of Alfred Adler, this extraordinary document adds to our knowledge of psychoanalytic history, including the significance of dreams in the evolution of psychoanalytic thought. Freud's commentary permitted the identification of a particular dream as his own. This dream had been presented in anonymity to the fledgling Vienna Psychoanalytic Society for interpretation. The dream was later inserted, again anonymously, into The Interpretation of Dreams with Freud's own remarkable pre-oedipal interpretation. Freud's conflicted relationships with Adler and Jung are considered in historical context.

  6. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Levetiracetam.

    Science.gov (United States)

    Petruševska, Marija; Berglez, Sandra; Krisch, Igor; Legen, Igor; Megušar, Klara; Peternel, Luka; Abrahamsson, Bertil; Cristofoletti, Rodrigo; Groot, D W; Kopp, Sabine; Langguth, Peter; Mehta, Mehul; Polli, James E; Shah, Vinod P; Dressman, Jennifer

    2015-09-01

    Literature and experimental data relevant for the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing levetiracetam are reviewed. Data on solubility and permeability suggest that levetiracetam belongs to class I of the biopharmaceutical classification system (BCS). Levetiracetam's therapeutic use, its wide therapeutic index, and its favorable pharmacokinetic properties make levetiracetam a valid candidate for the BCS-based biowaiver approach. Further, no BE studies with levetiracetam IR formulations in which the test formulation failed to show BE with the comparator have been reported in the open literature. On the basis of the overall evidence, it appears unlikely that a BCS-based biowaiver approach for levetiracetam IR solid oral dosage forms formulated with established excipients would expose patients to undue risks. Thus, the BCS-based biowaiver approach procedure is recommended for IR solid oral dosage form containing levetiracetam, provided the excipients in the formulation are also present in products that have been approved in countries belonging to or associated with the International Committee on Harmonization and are used in their usual quantities, and provided the dissolution profiles of the test and reference product comply with the current requirements for BCS-based biowaivers.

  7. Biowaiver monographs for immediate release solid oral dosage forms: levofloxacin.

    Science.gov (United States)

    Koeppe, Marcelle O; Cristofoletti, Rodrigo; Fernandes, Eduardo F; Storpirtis, Silvia; Junginger, Hans E; Kopp, Sabine; Midha, Kamal K; Shah, Vinod P; Stavchansky, Salomon; Dressman, Jennifer B; Barends, Dirk M

    2011-05-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing levofloxacin as the only active pharmaceutical ingredient (API) are reviewed. According to the current Biopharmaceutics Classification System, levofloxacin can be assigned to Class I. No problems with BE of IR levofloxacin formulations containing different excipients and produced by different manufacturing methods have been reported and hence the risk of bioinequivalence caused by these factors appears to be low. In addition, levofloxacin has a wide therapeutic index. On the basis of this evidence, a biowaiver is recommended for IR solid oral dosage forms containing levofloxacin as the single API provided that (a) the test product contains only excipients present in IR levofloxacin drug products that have been approved in International Conference on Harmonization (ICH) or associated countries and which have the same dosage form; (b) both the test and comparator dosage form are "very rapidly dissolving" or "rapidly dissolving" with similarity of the dissolution profiles demonstrated at pH 1.2, 4.5, and 6.8; and (c) if the test product contains polysorbates, it should be both qualitatively and quantitatively identical to its comparator in terms of polysorbate content.

  8. Biowaiver monographs for immediate release solid oral dosage forms: metronidazole.

    Science.gov (United States)

    Rediguieri, Camila F; Porta, Valentina; G Nunes, Diana S; Nunes, Taina M; Junginger, Hans E; Kopp, Sabine; Midha, Kamal K; Shah, Vinod P; Stavchansky, Salomon; Dressman, Jennifer B; Barends, Dirk M

    2011-05-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing metronidazole are reviewed. Metronidazole can be assigned to Biopharmaceutics Classification System Class I. Most BE studies that were identified reported the investigated formulations to be bioequivalent, indicating the risk of bioinequivalence to be low. Formulations showing differences in bioavailability showed dissimilarities in in vitro dissolution profiles. Furthermore, metronidazole has a wide therapeutic index. It is concluded that a biowaiver for solid IR formulations is justified, provided: (a) the test product and its comparator are both rapidly dissolving; (b) meet similarity of the dissolution profiles at pH 1.2, 4.5, and 6.8; (c) the test product contains only excipients present in IR drug products approved in International Conference on Harmonisation (ICH) or associated countries in the same dosage form; and (d) if the test product contains sorbitol, sodium laurilsulfate, or propylene glycol, the test product needs to be qualitatively and quantitatively identical to its comparator with respect to these excipients [corrected]..

  9. Biowaiver monographs for immediate release solid oral dosage forms: lamivudine.

    Science.gov (United States)

    Strauch, S; Jantratid, E; Dressman, J B; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2011-06-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing lamivudine as the only active pharmaceutical ingredient were reviewed. The solubility and permeability data of lamivudine as well as its therapeutic index, its pharmacokinetic properties, data indicating excipient interactions, and reported BE/bioavailability (BA) studies were taken into consideration. Lamivudine is highly soluble, but its permeability characteristics are not well-defined. Reported BA values in adults ranged from 82% to 88%. Therefore, lamivudine is assigned to the biopharmaceutics classification system (BCS) class III, noting that its permeability characteristics are near the border of BCS class I. Lamivudine is not a narrow therapeutic index drug. Provided that (a) the test product contains only excipients present in lamivudine IR solid oral drug products approved in the International Conference on Harmonization or associated countries in usual amounts and (b) the test product as well as the comparator product fulfills the BCS dissolution criteria for very rapidly dissolving; a biowaiver can be recommended for new lamivudine multisource IR products and major post-approval changes of marketed drug products.

  10. [Knowledge of German neurologists on migraine around 1890. Paul Julius Möbius and his 1894 monograph Die Migräne].

    Science.gov (United States)

    Schobeß, C; Steinberg, H

    2013-08-01

    Paul Julius Möbius (1853-1907), a Leipzig-based author and editor on a vast majority of subjects, has often been acknowledged as a leading 19th-century German neurologist. His impact on the development of knowledge on migraine has likewise been pointed to. This study compares the monograph published by Möbius on the illness in 1894 with contemporary publications and with present day best practice to establish if the author really made an essential contribution to the problem of migraine. As a representative of the central theory Möbius assumed that migraine was caused by aberrations in the brain. At the same time he made it clear that due to very limited diagnostic options this was only a hypothesis. Apart from a genetic factor and these cerebral changes, for Möbius the general state of health was a decisive factor and prevention and change in lifestyle therefore played a crucial role in his therapeutic recommendations. Basically there were only few differences between the views of Möbius and his colleagues, the major dissimilarity being that Möbius postulated a merely suggestive impact but no physical effect of electrotherapy. Although Möbius's monograph on migraine lacks originality, it provides a concise, easy to understand and stylistically impressive overview on the state of knowledge at that time. Therefore, the book can be considered as a benchmark publication of German speaking neurology around 1890 on migraine and it is highly recommended to present day headache and migraine researchers as well as historians of psychiatry and neurology.

  11. Job descriptions made easy.

    Science.gov (United States)

    Miller, Larry

    2014-01-01

    The act of writing a job description can be a daunting and difficult task for many managers. This article focuses on the key concepts of What, How, and Measureable Results as they relate to an employee's job duties. When the answers to these three elements are articulated, they define the core responsibilities of any job that form the basis for an effective job description.

  12. Description logics of context

    CSIR Research Space (South Africa)

    Klarman, S

    2013-05-01

    Full Text Available We introduce Description Logics of Context (DLCs) - an extension of Description Logics (DLs) for context-based reasoning. Our approach descends from J. McCarthy's tradition of treating contexts as formal objects over which one can quantify...

  13. Blade Testing Trends (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Desmond, M.

    2014-08-01

    As an invited guest speaker, Michael Desmond presented on NREL's NWTC structural testing methods and capabilities at the 2014 Sandia Blade Workshop held on August 26-28, 2014 in Albuquerque, NM. Although dynamometer and field testing capabilities were mentioned, the presentation focused primarily on wind turbine blade testing, including descriptions and capabilities for accredited certification testing, historical methodology and technology deployment, and current research and development activities.

  14. A brief description of South Africa's present-day climate

    CSIR Research Space (South Africa)

    Engelbrecht, F

    2010-08-01

    Full Text Available The time of writing of this introduction marks twenty years since former president FW de Klerk announced Nelson Mandela?s release and the effective acceleration of apartheid?s demise. South Africa was to see twenty years of unprecedented change, much...

  15. Multiple descriptions based wavelet image coding

    Institute of Scientific and Technical Information of China (English)

    CHEN Hai-lin(陈海林); YANG Yu-hang(杨宇航)

    2004-01-01

    We present a simple and efficient scheme that combines multiple descriptions coding with wavelet transform under JPEG2000 image coding architecture. To reduce packet losses, controlled amounts of redundancy are added to the wavelet transform coefficients to produce multiple descriptions of wavelet coefficients during the compression process to produce multiple descriptions bit-stream of a compressed image. Even if a receiver gets only parts of descriptions (other descriptions being lost), it can still reconstruct image with acceptable quality. Specifically, the scheme uses not only high-performance wavelet transform to improve compression efficiency, but also multiple descriptions technique to enhance the robustness of the compressed image that is transmitted through unreliable network channels.

  16. A Simplified Description of Fuzzy TOPSIS

    CERN Document Server

    Sodhi, Balwinder

    2012-01-01

    A simplified description of Fuzzy TOPSIS (Technique for Order Preference by Similarity to Ideal Situation) is presented. We have adapted the TOPSIS description from existing Fuzzy theory literature and distilled the bare minimum concepts required for understanding and applying TOPSIS. An example has been worked out to illustrate the application of TOPSIS for a multi-criteria group decision making scenario.

  17. A Semantic Similarity Measure for Expressive Description Logics

    CERN Document Server

    d'Amato, Claudia; Esposito, Floriana

    2009-01-01

    A totally semantic measure is presented which is able to calculate a similarity value between concept descriptions and also between concept description and individual or between individuals expressed in an expressive description logic. It is applicable on symbolic descriptions although it uses a numeric approach for the calculus. Considering that Description Logics stand as the theoretic framework for the ontological knowledge representation and reasoning, the proposed measure can be effectively used for agglomerative and divisional clustering task applied to the semantic web domain.

  18. Fundamentos Basicos de Career Education. Monografia en Career Education. [Basic Fundamentals of Career Education. Monograph in Career Education].

    Science.gov (United States)

    Office of Education (DHEW), Washington, DC.

    This document is the Spanish translation of ED 145 222, A Primer for Career Education. In this monograph, a view of the basic nature of the career education effort is discussed under the following topics: the basis of need for career education; the meaning and goals of career education; the difference between career education and vocational…

  19. Administration of Literacy Programmes. Planning, Administration and Monitoring in Literacy; Portfolio of Literacy Materials, Series 2, Monograph 2.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and the Pacific.

    The second of three related monographs resulting from a Unesco regional literacy workshop in Asia, this booklet provides information useful to those administering national programs in literacy training in underdeveloped and developing nations. The introduction discusses the reasons why an effective administration machinery for literacy and adult…

  20. Planning of Literacy Programmes. Planning, Administration and Monitoring in Literacy; Portfolio of Literacy Materials, Series 2, Monograph 1.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and the Pacific.

    The first of three related monographs resulting from a Unesco regional literacy workshop in Asia, this booklet provides information useful to those designing national programs in literacy training for underdeveloped and developing nations. Following an introduction, the booklet discusses the formulation of both policy guidelines and policy…

  1. Monitoring of Literacy Programmes. Planning, Administration and Monitoring in Literacy; Portfolio of Literacy Materials, Series 2, Monograph 3.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and the Pacific.

    The third of three related monographs resulting from a Unesco regional literacy workshop in Asia, this booklet provides information useful to those designing national programs in literacy training for underdeveloped and developing nations. The booklet is divided into four parts. The first part discusses the monitoring of literacy programs,…

  2. Suitability of a liquid chromatography assay of neomycin sulfate to replace the microbiological assay for neomycin in USP Monographs.

    Science.gov (United States)

    Hanko, Valoran P; Rohrer, Jeffrey S

    2010-01-01

    The current USP National Formulary contains 65 Monographs for drug formulations containing neomycin. All 65 Monographs prescribe a bioassay for neomycin assay. This bioassay, based on cell culture, is labor intensive, has poor precision, and cannot be adapted for purity or identification. High-performance anion-exchange chromatography with integrated pulsed amperometric detection (HPAE-IPAD), a liquid chromatography technique, has been shown to be suitable for neomycin purity analysis and neomycin assay of an over-the-counter first aid cream (Hanko and Rohrer [17]). Here we propose that an HPAE-IPAD assay can replace the bioassay in the 65 neomycin-containing Monographs. We applied the HPAE-IPAD assay to four neomycin-containing drug products representing the four classes of formulations found in the 65 Monographs, liquid, solid, suspension, and cream. Each drug was analyzed with two chromatography systems, and on 3 separate days. For all products, HPAE-IPAD measurements were precise and accurate with respect to the label concentrations. There was also high accuracy for spike recovery of neomycin from the four drug products throughout 70-150% of the labeled concentration. These results suggest that an HPAE-IPAD assay would be an accurate assay for neomycin, and would be faster and more precise than the current bioassay.

  3. Access to Elementary Education in India: Politics, Policies and Progress. CREATE Pathways to Access. Research Monograph No. 44

    Science.gov (United States)

    Little, Angela W.

    2010-01-01

    This monograph examines progress in, and policies for, access to elementary education over the past 60 years, the role played by political factors in the process of policy formulation and implementation and the drivers and inhibitors of the implementation of reforms in elementary education in recent years in India. Drawing on interviews and…

  4. Value Orientations of Vietnamese Culture. Cultural Monograph No. 3. Bilingual Multicultural Education Training Project for School Psychologists and Guidance Counselors.

    Science.gov (United States)

    Hallman, Clemens L.; And Others

    This teacher training monograph deals with value orientations of cultures in general with specific reference to Vietnamese culture. The first two sections discuss the conceptual issues of value orientation and give axiological definitions of the six clusters used to describe cultural orientation. The third section introduces the section on…

  5. The Geometry Description Markup Language

    Institute of Scientific and Technical Information of China (English)

    RadovanChytracek

    2001-01-01

    Currently,a lot of effort is being put on designing complex detectors.A number of simulation and reconstruction frameworks and applications have been developed with the aim to make this job easier.A very important role in this activity is played by the geometry description of the detector apparatus layout and its working environment.However,no real common approach to represent geometry data is available and such data can be found in various forms starting from custom semi-structured text files,source code (C/C++/FORTRAN),to XML and database solutions.The XML(Extensible Markup Language)has proven to provide an interesting approach for describing detector geometries,with several different but incompatible XML-based solutions existing.Therefore,interoperability and geometry data exchange among different frameworks is not possible at present.This article introduces a markup language for geometry descriptions.Its aim is to define a common approach for sharing and exchanging of geometry description data.Its requirements and design have been driven by experience and user feedback from existing projects which have their geometry description in XML.

  6. Description of vegetation types

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document provides descriptions of five vegetation types found in Iowa- oak savannah, mature hardwoods, floodplain woods, scrub woods, and riparian woods. Oak...

  7. Data Matching, Integration, and Interoperability for a Metric Assessment of Monographs

    DEFF Research Database (Denmark)

    Zuccala, Alesia Ann; Cornacchia, Roberto

    2016-01-01

    in a new Microsoft SQL database. The purpose of the experiment was to investigate co-varied metrics for a list of book titles based on their citation impact (from Scopus), presence in international libraries (WorldCat.org) and visibility as publically reviewed items (Goodreads). The results of our data......This paper details a unique data experiment carried out at the University of Amsterdam, Center for Digital Humanities. Data pertaining to monographs were collected from three autonomous resources, the Scopus Journal Index, WorldCat.org and Goodreads, and linked according to unique identifiers...... experiment highlighted current problems related citation indices and the way that books are recorded by different citing authors. Our research further demonstrates the primary problem of matching book titles as ‘cited objects’ with book titles held in a union library catalog, given that books are always...

  8. Present time

    CERN Document Server

    Romero, Gustavo E

    2014-01-01

    The idea of a moving present or `now' seems to form part of our most basic beliefs about reality. Such a present, however, is not reflected in any of our theories of the physical world. I show in this article that presentism, the doctrine that only what is present exists, is in conflict with modern relativistic cosmology and recent advances in neurosciences. I argue for a tenseless view of time, where what we call `the present' is just an emergent secondary quality arising from the interaction of perceiving self-conscious individuals with their environment. I maintain that there is no flow of time, but just an ordered system of events.

  9. Semantic foundation for preferential description logics

    CSIR Research Space (South Africa)

    Britz, K

    2011-12-01

    Full Text Available that they refer to as concept models. They present representation results for the description logic ALC for both preferential and rational consequence relations. They argue that their semantics pave the way for extending preferential and rational consequence...

  10. CATCHY PRESENTATIONS

    DEFF Research Database (Denmark)

    Eriksen, Kaare; Tollestrup, Christian; Ovesen, Nis

    2011-01-01

    An important competence for designers is the ability to communicate and present ideas and proposals for customers, partners, investors and colleagues. The Pecha Kucha principle, developed by Astrid Klein and Mark Dytham, has become a widely used and easy format for the presentation of new concepts...

  11. Reliability of semiology description.

    Science.gov (United States)

    Heo, Jae-Hyeok; Kim, Dong Wook; Lee, Seo-Young; Cho, Jinwhan; Lee, Sang-Kun; Nam, Hyunwoo

    2008-01-01

    Seizure semiology is important for classifying patients' epilepsy. Physicians usually get most of the seizure information from observers though there have been few reports on the reliability of the observers' description. This study aims at determining the reliability of observers' description of the semiology. We included 92 patients who had their habitual seizures recorded during video-EEG monitoring. We compared the semiology described by the observers with that recorded on the videotape, and reviewed which characteristics of the observers affected the reliability of their reported data. The classification of seizures and the individual components of the semiology based only on the observer-description was somewhat discordant compared with the findings from the videotape (correct classification, 85%). The descriptions of some ictal behaviors such as oroalimentary automatism, tonic/dystonic limb posturing, and head versions were relatively accurate, but those of motionless staring and hand automatism were less accurate. The specified directions by the observers were relatively correct. The accuracy of the description was related to the educational level of the observers. Much of the information described by well-educated observers is reliable. However, every physician should keep in mind the limitations of this information and use this information cautiously.

  12. Career Path Descriptions

    CERN Document Server

    Charkiewicz, A

    2000-01-01

    Before the Career Path system, jobs were classified according to grades with general statutory definitions, guided by the "Job Catalogue" which defined 6 evaluation criteria with example illustrations in the form of "typical" job descriptions. Career Paths were given concise statutory definitions necessitating a method of description and evaluation adapted to their new wider-band salary concept. Evaluations were derived from the same 6 criteria but the typical descriptions became unusable. In 1999, a sub-group of the Standing Concertation Committee proposed a new guide for describing Career Paths, adapted to their wider career concept by expanding the 6 evaluation criteria into 9. For each criterion several levels were established tracing the expected evolution of job level profiles and personal competencies over their longer salary ranges. While providing more transparency to supervisors and staff, the Guide's official use would be by services responsible for vacancy notices, Career Path evaluations and rela...

  13. Information Presentation

    Science.gov (United States)

    Holden, Kritina L.; Thompson, Shelby G.; Sandor, Aniko; McCann, Robert S.; Kaiser, Mary K.; Adelstein, Barnard D.; Begault, Durand R.; Beutter, Brent R.; Stone, Leland S.; Godfroy, Martine

    2009-01-01

    The goal of the Information Presentation Directed Research Project (DRP) is to address design questions related to the presentation of information to the crew. In addition to addressing display design issues associated with information formatting, style, layout, and interaction, the Information Presentation DRP is also working toward understanding the effects of extreme environments encountered in space travel on information processing. Work is also in progress to refine human factors-based design tools, such as human performance modeling, that will supplement traditional design techniques and help ensure that optimal information design is accomplished in the most cost-efficient manner. The major areas of work, or subtasks, within the Information Presentation DRP for FY10 are: 1) Displays, 2) Controls, 3) Procedures and Fault Management, and 4) Human Performance Modeling. The poster will highlight completed and planned work for each subtask.

  14. Information Presentation

    Science.gov (United States)

    Holden, K.L.; Boyer, J.L.; Sandor, A.; Thompson, S.G.; McCann, R.S.; Begault, D.R.; Adelstein, B.D.; Beutter, B.R.; Stone, L.S.

    2009-01-01

    The goal of the Information Presentation Directed Research Project (DRP) is to address design questions related to the presentation of information to the crew. The major areas of work, or subtasks, within this DRP are: 1) Displays, 2) Controls, 3) Electronic Procedures and Fault Management, and 4) Human Performance Modeling. This DRP is a collaborative effort between researchers at Johnson Space Center and Ames Research Center.

  15. A short biography of Hubert Ludwig and a note on the publication dates of his monograph Die Seewalzen (1889-1892).

    Science.gov (United States)

    Reich, Mike

    2015-12-03

    The dates of publication of Hubert Ludwig's (1852-1913) comprehensive monograph Die Seewalzen [= Sea cucumbers] are reviewed. The precise publication dates of his volume, originally published in 16 fascicles and 8 parts/issues, delivered between 1889 and 1892, has been re-examined. Additionally, a short biographical note on Hubert Ludwig's life and a discussion of all new taxa introduced by him in his monograph is given.

  16. Generalizing: The descriptive struggle

    OpenAIRE

    Barney G Glaser, Ph.D.; Hon Ph.D.

    2006-01-01

    The literature is not kind to the use of descriptive generalizations. Authors struggle and struggle to find and rationalize a way to use them and then fail in spite of trying a myriad of work-arounds. And then we have Lincoln and Guba’s famous statement: “The only generalization is: there is no generalization” in referring to qualitative research. (op cit, p. 110) They are referring to routine QDA yielding extensive descriptions, but which tacitly include conceptual generalizations without an...

  17. CRAC2 model description

    Energy Technology Data Exchange (ETDEWEB)

    Ritchie, L.T.; Alpert, D.J.; Burke, R.P.; Johnson, J.D.; Ostmeyer, R.M.; Aldrich, D.C.; Blond, R.M.

    1984-03-01

    The CRAC2 computer code is a revised version of CRAC (Calculation of Reactor Accident Consequences) which was developed for the Reactor Safety Study. This document provides an overview of the CRAC2 code and a description of each of the models used. Significant improvements incorporated into CRAC2 include an improved weather sequence sampling technique, a new evacuation model, and new output capabilities. In addition, refinements have been made to the atmospheric transport and deposition model. Details of the modeling differences between CRAC2 and CRAC are emphasized in the model descriptions.

  18. Olkiluoto site description 2011

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-12-15

    This fourth version of the Olkiluoto Site Report, produced by the OMTF (Olkiluoto Modelling Task Force), updates the Olkiluoto Site Report 2008 with the data and knowledge obtained up to December 2010. A descriptive model of the site (the Site Descriptive Model, SDM), i.e. a model describing the geological and hydrogeological structure of the site, properties of the bedrock and the groundwater and its flow, and the associated interacting processes and mechanisms. The SDM is divided into six parts: surface system, geology, rock mechanics, hydrogeology, hydrogeochemistry and transport properties.

  19. A Description Logic Primer

    CERN Document Server

    Krötzsch, Markus; Horrocks, Ian

    2012-01-01

    This paper provides a self-contained first introduction to description logics (DLs). The main concepts and features are explained with examples before syntax and semantics of the DL SROIQ are defined in detail. Additional sections review light-weight DL languages, discuss the relationship to the Web Ontology Language OWL and give pointers to further reading.

  20. Generalizing: The descriptive struggle

    Directory of Open Access Journals (Sweden)

    Barney G. Glaser, Ph.D.; Hon Ph.D.

    2006-11-01

    Full Text Available The literature is not kind to the use of descriptive generalizations. Authors struggle and struggle to find and rationalize a way to use them and then fail in spite of trying a myriad of work-arounds. And then we have Lincoln and Guba’s famous statement: “The only generalization is: there is no generalization” in referring to qualitative research. (op cit, p. 110 They are referring to routine QDA yielding extensive descriptions, but which tacitly include conceptual generalizations without any real thought of knowledge about them. In this chapter I wish to explore this struggle for the purpose of explaining that the various contra arguments to using descriptive generalizations DO NOT apply to the ease of using conceptual generalizations yielded in SGT and especially FGT. I will not argue for the use of descriptive generalization. I agree with Lincoln and Guba with respect to QDA, “the only generalization is: there is no generalization.” It is up to the QDA methodologists, of whom there are many; to continue the struggle and I wish them well.

  1. SUBJECTIVE DESCRIPTION OF TRAINEES.

    Science.gov (United States)

    PEARCE, FRANK C.

    THIS REPORT GIVES A SUBJECTIVE DESCRIPTION OF THE GENERAL POPULATION FROM WHICH TRAINEES FOR THE MODESTO MULTI-OCCUPATIONAL PROJECT WERE SELECTED. IT INCLUDES AN EXTENSIVE STUDY OF THE SOCIOLOGICAL BACKGROUND OF A GROUP OF WHITE MIGRANTS WHO MOVED FROM THE EASTERN UNITES STATES TO CALIFORNIA. THE AUTHOR ALSO INCLUDED REFERENCES TO THE CHANGING…

  2. Voting Present

    Directory of Open Access Journals (Sweden)

    James Lo

    2013-12-01

    Full Text Available During his time as a state senator in Illinois, Barack Obama voted “Present” 129 times, a deliberate act of nonvoting that subsequently became an important campaign issue during the 2008 presidential elections. In this article, I examine the use of Present votes in the Illinois state senate. I find evidence that Present votes can largely be characterized as protest votes used as a legislative tool by the minority party. Incorporating information from Present votes into a Bayesian polytomous item-response model, I find that this information increases the efficiency of ideal point estimates by approximately 35%. There is little evidence of significant moderation by Obama when Present votes are accounted for, though my results suggest that Obama’s voting record may have moderated significantly before his subsequent election to the U.S. Senate. My results also suggest that because legislative nonvoting may occur for a variety of reasons, naive inclusion of nonvoting behavior into vote choice models may lead to biased results.

  3. Multiple Descriptions Using Sparse Decompositions

    DEFF Research Database (Denmark)

    Jensen, Tobias Lindstrøm; Østergaard, Jan; Dahl, Joachim

    2010-01-01

    In this paper, we consider the design of multiple descriptions (MDs) using sparse decompositions. In a description erasure channel only a subset of the transmitted descriptions is received. The MD problem concerns the design of the descriptions such that they individually approximate the source...

  4. Formal description of the OSI session layer: session service

    NARCIS (Netherlands)

    van Sinderen, Marten J.; van Eijk, P.H.J.; Vissers, C.A.; Diaz, M.

    1989-01-01

    The LOTOS formal description of the OSI session service is presented on basis of specification samples from the full description, giving account of how specification styles and session service architectural elements are reflected in the description. Both information (data types) and process

  5. Technical presentation

    CERN Multimedia

    FI Department

    2008-01-01

    RADIOSPARES, the leading catalogue distributor of components (electronic, electrical, automation, etc.) and industrial supplies will be at CERN on Friday 3 October 2008 (Main Building, Room B, from 9.00 a.m. to 3.00 p.m.) to introduce its new 2008/2009 catalogue. This will be the opportunity for us to present our complete range of products in more detail: 400 000 part numbers available on our web site (Radiospares France, RS International, extended range of components from other manufacturers); our new services: quotations, search for products not included in the catalogue, SBP products (Small Batch Production: packaging in quantities adapted to customers’ requirements); partnership with our focus manufacturers; demonstration of the on-line purchasing tool implemented on our web site in conjunction with CERN. RADIOSPARES will be accompanied by representatives of FLUKE and TYCO ELECTRONICS, who will make presentations, demonstrate materials and answer any technical questio...

  6. Overview Presentation

    Science.gov (United States)

    Lytle, John

    2001-01-01

    This report provides an overview presentation of the 2000 NPSS (Numerical Propulsion System Simulation) Review and Planning Meeting. Topics include: 1) a background of the program; 2) 1999 Industry Feedback; 3) FY00 Status, including resource distribution and major accomplishments; 4) FY01 Major Milestones; and 5) Future direction for the program. Specifically, simulation environment/production software and NPSS CORBA Security Development are discussed.

  7. Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.

    Science.gov (United States)

    Chiu, Weihsueh A; Guyton, Kathryn Z; Martin, Matthew T; Reif, David M; Rusyn, Ivan

    2017-07-24

    Evidence regarding carcinogenic mechanisms serves a critical role in International Agency for Research on Cancer (IARC) Monograph evaluations. Three recent IARC Working Groups pioneered inclusion of the US Environmental Protection Agency (EPA) ToxCast program high-throughput screening (HTS) data to supplement other mechanistic evidence. In Monograph V110, HTS profiles were compared between perfluorooctanoic acid (PFOA) and prototypical activators across multiple nuclear receptors. For Monograph V112 -113, HTS assays were mapped to 10 key characteristics of carcinogens identified by an IARC expert group, and systematically considered as an additional mechanistic data stream. Both individual assay results and ToxPi-based rankings informed mechanistic evaluations. Activation of multiple nuclear receptors in HTS assays showed that PFOA targets peroxisome proliferator activated and other receptors. ToxCast assays substantially covered 5 of 10 key characteristics, corroborating literature evidence of "induces oxidative stress" and "alters cell proliferation, cell death or nutrient supply" and filling gaps for "modulates receptor-mediated effects." Thus, ToxCast HTS data were useful both in evaluating specific mechanistic hypotheses and in the overall evaluation of mechanistic evidence. However, additional HTS assays are needed to provide more comprehensive coverage of the 10 key characteristics of carcinogens that form the basis of current IARC mechanistic evaluations.

  8. Oak Ridge TNS Program: system description manual

    Energy Technology Data Exchange (ETDEWEB)

    Reid, R.L.; Becraft, W.R.; Brown, T.G.; Peng, Y.K.M.; Sardella, C.; Shannon, T.E.; Steiner, D.; Wells, W.M.; Wiseman, G.W.

    1979-05-01

    This document provides a systems description of the Reference Design for The Next Step (TNS) evolved at Oak Ridge National Laboratory (ORNL) during FY 1978. The description is presented on the basis of 24 individual device and facility systems. Additional information on these systems, the Reference Design, and the FY 1978 Oak Ridge TNS activities can be found in the associated technical memoranda, ORNL/TM-6720 and ORNL/TM-6722--ORNL/TM-6733.

  9. Review of the monograph “Corruption: nature, revelation, interaction” / editor-in-chief Academician of the Russian Academy of Sciences T. Ya. Khabrieva. Мoscow: “Yurisprudentsiya” Publishers, 2014, 688 p.

    Directory of Open Access Journals (Sweden)

    Sergey F. Milyukov

    2016-03-01

    Full Text Available The review presents the authorsrsquo opinion of the monograph ldquoCorruption nature revelation interactionrdquo editorinchief Academician of the Russian Academy of Sciences T. Ya. Khabrieva. Selected chapters and paragraphs are reviewed and analyzed. The authors note both positive and negative sides of the monograph. The concept of corruption as a social phenomenon is discussed as well as the need to implement international norms in national legislation the legal framework for combating corruption in Russia the activities of the various institutions to fight against corruption combating corruption in state and municipal service ways of overcoming the corruption potential of legal acts impact of corruption on business and methods of combating corruption abroad. The team of authors including a large number of wellknown scientists and politicians S. B. Ivanov S. B. Naryshkin S. V. Stepashin Yu. A. Tikhomirov A. V. Fedorov T. Ya. Khabrieva etc. view corruption as a social phenomenon highlight the issues of international cooperation on corruption issues give a detailed review of legislation including international on combating corruption and name individual institutions to counteract this dangerous phenomenon. Special chapters are devoted to corruption in the system of state and municipal service and corruption in the business sector. Detailed attention in a separate chapter is given to the institution of anticorruption expertise. nbsp

  10. Technical presentation

    CERN Multimedia

    FP Department

    2009-01-01

    07 April 2009 Technical presentation by Leuze Electronics: 14.00 – 15.00, Main Building, Room 61-1-017 (Room A) Photoelectric sensors, data identification and transmission systems, image processing systems. We at Leuze Electronics are "the sensor people": we have been specialising in optoelectronic sensors and safety technology for accident prevention for over 40 years. Our dedicated staff are all highly customer oriented. Customers of Leuze Electronics can always rely on one thing – on us! •\tFounded in 1963 •\t740 employees •\t115 MEUR turnover •\t20 subsidiaries •\t3 production facilities in southern Germany Product groups: •\tPhotoelectric sensors •\tIdentification and measurements •\tSafety devices

  11. RETRIEVAL EQUIPMENT DESCRIPTIONS

    Energy Technology Data Exchange (ETDEWEB)

    J. Steinhoff

    1997-08-25

    The objective and the scope of this document are to list and briefly describe the major mobile equipment necessary for waste package (WP) retrieval from the proposed subsurface nuclear waste repository at Yucca Mountain. Primary performance characteristics and some specialized design features of the equipment are explained and summarized in the individual subsections of this document. There are no quality assurance requirements or QA controls in this document. Retrieval under normal conditions is accomplished with the same fleet of equipment as is used for emplacement. Descriptions of equipment used for retrieval under normal conditions is found in Emplacement Equipment Descriptions, DI: BCAF00000-01717-5705-00002 (a document in progress). Equipment used for retrieval under abnormal conditions is addressed in this document and consists of the following: (1) Inclined Plane Hauler; (2) Bottom Lift Transporter; (3) Load Haul Dump (LHD) Loader; (4) Heavy Duty Forklift for Emplacement Drifts; (5) Covered Shuttle Car; (6) Multipurpose Vehicle; and (7) Scaler.

  12. Biowaiver monographs for immediate-release solid oral dosage forms: Zidovudine (azidothymidine).

    Science.gov (United States)

    Soares, Kelen C C; Rediguieri, Camila F; Souza, Jacqueline; Serra, Cristina Helena R; Abrahamsson, Bertil; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Dressman, Jennifer

    2013-08-01

    Literature data on the properties of zidovudine relevant to waiver of in vivo bioequivalence (BE) testing requirements for the approval of immediate-release (IR) solid oral dosage forms containing zidovudine alone or in combination with other active pharmaceutical ingredients (APIs) are reviewed. Solubility, dissolution, and permeability data for zidovudine, along with its dosing schedule, therapeutic index and pharmacokinetic properties, and reports related to BE/bioavailability were all taken into consideration. Data for solubility and permeability suggest that zidovudine belongs to Class I according to the Biopharmaceutics Classification System. Also, zidovudine is not a narrow therapeutic index drug. Although five out of 13 formulations tested in vivo (mostly of unreported composition) failed to show BE, it appears that in vitro studies performed according to biowaiver methods could predict in vivo behavior. Nevertheless, it is highly recommended that if a biowaiver is to be applied, excipient choices be limited to those found in IR drug products approved in International Conference on Harmonisation (ICH) or associated countries in the same dosage form (Table 2 of this monograph), in their usual amounts. These conclusions apply to products containing zidovudine as the only API and also to fixed combination products containing zidovudine with respect to the zidovudine component of the formulation.

  13. Tools to Ensure Safe Medicines: New Monograph Tests in USP-NF

    Directory of Open Access Journals (Sweden)

    Catherine Sheehan

    2010-09-01

    Full Text Available This paper describes USP-NF compendial updates to six ‘high-priority” excipient monographs: Glycerin, Propylene Glycol, Sorbitol Solution, Sorbitol Sorbitan Solution, Noncrystallizing Sorbitol Solution and Maltitol Solution. The USP-NF revisions arose from the Food and DrugAdministration’s (FDA’s requests to include, as part of each monograph’s Identification test, a limit test to detect the presence of Diethylene Glycol (DEG, a toxic adulterant. These revisions alignwith the 2007 FDA Guidance for Industry: Testing of Glycerin for Diethylene Glycol (1, that drug product manufacturers perform a specific identity test for DEG on all containers of all lots ofglycerin before glycerin is used in the manufacture and preparation of drug products. This paper describes several risk factors due to a complex global excipient supply chain, nonspecific specifications, inadequate supply chain qualification, and poor understanding of regulations. Strengthening and conformance to compendial specifications is one of the tools necessary to mitigate risk and help prevent the next DEG adulteration that is part of USP’s efforts to ensure safe medicines.

  14. Clinical roundtable monograph. New alternatives in CLL therapy: managing adverse events.

    Science.gov (United States)

    Chanan-Khan, Asher; Kipps, Thomas; Stilgenbauer, Stephan

    2010-08-01

    Chronic lymphocytic leukemia (CLL) is a B-cell leukemia mainly affecting older adults. Historically, CLL has been regarded as an incurable disease, and treatment has been confined to cytotoxic chemotherapy regimens. However, prognosis for patients treated with these agents remained poor, prompting the development of new, targeted agents. The introduction of rituximab, a CD20-targeted monoclonal antibody, revolutionized the treatment for this disease. Rituximab in combination with fludarabine improved response rates and length of progression-free survival. The success of rituximab in this setting has prompted the development of many more investigational agents for CLL, including other antibody agents. However, as with any medication, the potential benefit achieved with CLL therapies is mitigated by the safety risk for the patient. These agents have been associated with adverse events such as immunosuppression, reactivation of cytomegalovirus, and infusion-related reactions that can occur with antibody administration. Adverse events can greatly affect the patient’s quality of life and ability to tolerate therapy. Management of adverse events is a critical component of the overall treatment strategy for CLL, particularly in elderly patients. In this clinical roundtable monograph, 3 expert physicians discuss the latest clinical studies evaluating the treatment of CLL, focusing on the adverse events associated with each agent and the potential interventions that can be used to manage their occurrence.

  15. Clinical roundtable monograph: Unmet needs in the management of chronic myelogenous leukemia.

    Science.gov (United States)

    Jabbour, Elias J; Bixby, Dale; Akard, Luke P

    2012-12-01

    Approximately 5,000 cases of chronic myelogenous leukemia (CML) are diagnosed each year in the United States. The introduction of tyrosine kinase inhibitors (TKIs) has dramatically improved survival time for many CML patients. Current first-line treatment options include imatinib and the second-generation agents nilotinib and dasatinib. Second- and third-line agents include nilotinib, dasatinib, bosutinib, and the new agent ponatinib. Despite the effectiveness of TKIs, some patients develop resistance or intolerance to these agents. A number of mutations of the BCR-ABL gene have been identified and are associated with TKI resistance. Patients may benefit from switching to a second-line TKI, undergoing hematopoietic stem cell transplant, or receiving newly emerging agents. Although early response is associated with improved patient outcome, clinicians lack tests that can determine which patients will benefit from which therapies. To ensure adequate response, patients should be monitored by both polymerase chain reaction and cytogenetic analysis of the bone marrow. This roundtable monograph reviews key unmet needs in patients with CML related to disease management and treatment options.

  16. Clinical roundtable monograph: new and emerging treatments for advanced prostate cancer.

    Science.gov (United States)

    George, Daniel J; Kantoff, Philip W; Lin, Daniel W

    2011-06-01

    Historically, the treatment of metastatic castration-resistant prostate cancer (CRPC) has been limited to chemotherapeutic regimens that did not improve patient survival. In 2004, clinical studies began to demonstrate significant improvements in patient outcomes, including overall survival, with docetaxel versus mitoxantrone chemotherapy. Since these pivotal trials, the combination of docetaxel plus prednisone has become a standard of care for patients with metastatic CRPC. However, the limited survival benefit achieved with this regimen prompted several investigations into the development of alternative therapeutic options. Recent advances have now led to an unprecedented number of new drug approvals within the past year, providing many new treatment options for patients with metastatic CRPC. Sipuleucel-T, considered a new paradigm in cancer treatment, is the first such immunotherapeutic agent approved by the US Food and Drug Administration. Other successes include abiraterone acetate, the first androgen biosynthesis inhibitor, and cabazitaxel, a novel microtubule inhibitor, both of which have demonstrated improved survival following docetaxel failure. The bone-targeting agent denosumab, also recently approved in this setting, offers these patients significant improvement in the prevention of skeletal-related events. The data supporting the approval of each of these agents are described in this monograph, as are current approaches in the treatment of metastatic CRPC and ongoing clinical trials of novel treatments and strategies. The experts also discuss several of the issues regarding the introduction of these novel agents into clinical practice for metastatic CRPC patients.

  17. Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Amoxicillin Trihydrate.

    Science.gov (United States)

    Thambavita, Dhanusha; Galappatthy, Priyadarshani; Mannapperuma, Uthpali; Jayakody, Lal; Cristofoletti, Rodrigo; Abrahamsson, Bertil; Groot, Dirk W; Langguth, Peter; Mehta, Mehul; Parr, Alan; Polli, James E; Shah, Vinod P; Dressman, Jennifer

    2017-10-01

    Literature and experimental data relevant to waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release solid oral dosage forms containing amoxicillin trihydrate are reviewed. Solubility and permeability characteristics according to the Biopharmaceutics Classification System (BCS), therapeutic uses, therapeutic index, excipient interactions, as well as dissolution and BE and bioavailability studies were taken into consideration. Solubility and permeability studies indicate that amoxicillin doses up to 875 mg belong to BCS class I, whereas 1000 mg belongs to BCS class II and doses of more than 1000 mg belong to BCS class IV. Considering all aspects, the biowaiver procedure can be recommended for solid oral products of amoxicillin trihydrate immediate-release preparations containing amoxicillin as the single active pharmaceutical ingredient at dose strengths of 875 mg or less, provided (a) only the excipients listed in this monograph are used, and only in their usual amounts, (b) the biowaiver study is performed according to the World Health Organization-, U.S. Food and Drug Administration-, or European Medicines Agency-recommended method using the innovator as the comparator, and (c) results comply with criteria for "very rapidly dissolving" or "similarly rapidly dissolving." Products containing other excipients and those containing more than 875 mg amoxicillin per unit should be subjected to an in vivo BE study. Copyright © 2017 American Pharmacists Association®. All rights reserved.

  18. Tools to Ensure Safe Medicines: New Monograph Tests in USP-NF

    Directory of Open Access Journals (Sweden)

    Catherine Sheehan

    2010-06-01

    Full Text Available This paper describes USP-NF compendial updates to six ‘high-priority” excipient monographs: Glycerin, Propylene Glycol, Sorbitol Solution, Sorbitol Sorbitan Solution, Noncrystallizing Sorbitol Solution and Maltitol Solution. The USP-NF revisions arose from the Food and Drug Administration’s (FDA’s requests to include, as part of each monograph’s Identification test, a limit test to detect the presence of Diethylene Glycol (DEG, a toxic adulterant. These revisions align with the 2007 FDA Guidance for Industry: Testing of Glycerin for Diethylene Glycol (1, that drug product manufacturers perform a specific identity test for DEG on all containers of all lots of glycerin before glycerin is used in the manufacture and preparation of drug products. This paper describes several risk factors due to a complex global excipient supply chain, nonspecific specifications, inadequate supply chain qualification, and poor understanding of regulations. Strengthening and conformance to compendial specifications is one of the tools necessary to mitigate risk and help prevent the next DEG adulteration that is part of USP’s efforts to ensure safe medicines.

  19. Mining skeletal phenotype descriptions from scientific literature.

    Directory of Open Access Journals (Sweden)

    Tudor Groza

    Full Text Available Phenotype descriptions are important for our understanding of genetics, as they enable the computation and analysis of a varied range of issues related to the genetic and developmental bases of correlated characters. The literature contains a wealth of such phenotype descriptions, usually reported as free-text entries, similar to typical clinical summaries. In this paper, we focus on creating and making available an annotated corpus of skeletal phenotype descriptions. In addition, we present and evaluate a hybrid Machine Learning approach for mining phenotype descriptions from free text. Our hybrid approach uses an ensemble of four classifiers and experiments with several aggregation techniques. The best scoring technique achieves an F-1 score of 71.52%, which is close to the state-of-the-art in other domains, where training data exists in abundance. Finally, we discuss the influence of the features chosen for the model on the overall performance of the method.

  20. Heparin sodium compliance to the new proposed USP monograph: elucidation of a minor structural modification responsible for a process dependent 2.10 ppm NMR signal.

    Science.gov (United States)

    Mourier, Pierre A J; Guichard, Olivier Y; Herman, Fréderic; Viskov, Christian

    2011-01-25

    Heparin is a highly sulfated hetero polysaccharide mixture found and extracted from mammalian tissues. It has been widely used as an anticoagulant drug during the past decades. In the new proposed USP heparin monograph, the ¹H NMR acceptance criteria to prevent contamination by over sulfated chondroitin sulfate (OSCS), or other persulfated glycosaminoglycans, specifies that no unidentified signals greater than 4% of the mean of signal height of 1 and 2 should be present in the following ranges: 0.10-2.00, 2.10-3.20, and 5.70-8.00 ppm. However, those criteria do not take into account the impact of potential structural modifications generated by the heparin manufacturing processes. In fact, starting from pig mucosa, heparin purification involves oxidizing reagents such as sodium peroxide, potassium permanganate and peracetic acid. In the present work, we demonstrate that potassium permanganate treated heparins show a small but characteristic extra signal at 2.10 ppm. Controlled heparinase I depolymerisation is used to target and excise the oligosaccharide responsible for this extra signal from the polysaccharide backbone. By using orthogonal chromatographic techniques, the fingerprint oligosaccharide was isolated and its structure elucidated. Without the identification of this structural moiety, such purified heparins may have been considered as non-compliant drug substance and not suitable for pharmaceutical use. Copyright © 2010 Elsevier B.V. All rights reserved.

  1. Distributed multiple description coding

    CERN Document Server

    Bai, Huihui; Zhao, Yao

    2011-01-01

    This book examines distributed video coding (DVC) and multiple description coding (MDC), two novel techniques designed to address the problems of conventional image and video compression coding. Covering all fundamental concepts and core technologies, the chapters can also be read as independent and self-sufficient, describing each methodology in sufficient detail to enable readers to repeat the corresponding experiments easily. Topics and features: provides a broad overview of DVC and MDC, from the basic principles to the latest research; covers sub-sampling based MDC, quantization based MDC,

  2. From description to prescription

    DEFF Research Database (Denmark)

    McQuaid, Sara Dybris

    From Description to Prescription: Politics of Recognition, Consociational Theory and the Conflict in Northern Ireland. Within academic discourses on Northern Ireland the politics of recognition and particularly the theory of consociational democracy has made a profound impact. First introduced...... politico-cultural antagonisms in Northern Ireland. However, the terms ‘consociationalism’ or ‘consociational democracy’ are wholly absent from political discourses: they are never used in any of the governmental and constitutional documents between 1969 and 2006. As such, juxtaposing academic literature...... to integration, eventually converged in authoritative academic and political discourses....

  3. Description of surface systems. Preliminary site description Simpevarp sub area - Version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Lindborg, Tobias (ed.)

    2005-03-01

    Swedish Nuclear Fuel and Waste Management Co is currently conducting site characterisation in the Simpevarp area. The area is divided into two subareas, the Simpevarp and the Laxemar subarea. The two subareas are surrounded by a common regional model area, the Simpevarp area. This report describes both the regional area and the subareas. This report is an interim version (model version 1.2) of the description of the surface systems at the Simpevarp area, and should be seen as a background report to the site description of the Simpevarp area, version 1.2, SKB-R--05-08. The basis for this description is quality-assured field data available in the SKB SICADA and GIS databases, together with generic data from the literature. The Surface system, here defined as everything above the bedrock, comprises a number of separate disciplines (e.g. hydrology, geology, topography, oceanography and ecology). Each discipline has developed descriptions and models for a number of properties that together represent the site description. The current methodology for developing the surface system description and the integration to ecosystem models is documented in a methodology strategy report SKB-R--03-06. The procedures and guidelines given in that report were followed in this report. Compared with version 1.1 of the surface system description SKB-R--04-25, this report presents considerable additional features, especially in the ecosystem description (Chapter 4) and in the description of the surface hydrology (Section 3.4). A first attempt has also been made to connect the flow of matter (carbon) between the different ecosystems into an overall ecosystem model at a landscape level. A summarised version of this report is also presented in SKB-R--05-08 together with geological-, hydrogeological-, transport properties-, thermal properties-, rock mechanics- and hydrogeochemical descriptions.

  4. Descripción de las especies del género Ipomoea presentes en el area de riego del río Dulce, Santiago del Estero, Argentina Description of the species of the genus Ipomoea in the irrigated area of Río Dulce, Santiago del Estero, Argentina

    Directory of Open Access Journals (Sweden)

    E. del V. Carrizo

    2001-08-01

    Full Text Available El objetivo del presente trabajo fue relevar y diferenciar especies del género Ipomoea presentes en diferentes fases de desarrollo, en el área de riego del Río Dulce, Santiago del Estero, Argentina. Para ello fueron herborizados y fotografiados diversos ejemplares encontrados en la región. En el laboratorio, después del trabajo de identificación, fueron descritas las diversas fases de desarrollo de la planta: semilla, plántula y estado adulto, creándose códigos de identificación para cada fase. Se registraron ocho especies del género Ipomoea, I. alba; I. amnicola; I. cairica; I. carnea; I. grandifolia; I. nil; I. purpurea e I. quamoclit, algunas de las cuales se cultivan como ornamentales, otras aparecen como ruderales y algunas son malezas en cultivos de la región.The objective of this research was to describe and differentiate the stages of species of the genus Ipomoea in the irrigated area of Rio Dulce - Santiago del Estero - Argentina, under different growth stages. Species prototypes from the area were mounted in a herbarium, photographed and then identified with detailed descriptions of the seed, seedling and mature stages. A classification key was constructed to identify them under different growth stages. Eight species in the genus Ipomoea: (I. alba, I. amnicola, I. cairica, I. carnea, I. grandifolia, I. nil, I. purpurea and I. quamoclit were registered, some cultivated as ornamental, while others appear naturally or as crop weeds in the region.

  5. Qualitative Descriptive Methods in Health Science Research.

    Science.gov (United States)

    Colorafi, Karen Jiggins; Evans, Bronwynne

    2016-07-01

    The purpose of this methodology paper is to describe an approach to qualitative design known as qualitative descriptive that is well suited to junior health sciences researchers because it can be used with a variety of theoretical approaches, sampling techniques, and data collection strategies. It is often difficult for junior qualitative researchers to pull together the tools and resources they need to embark on a high-quality qualitative research study and to manage the volumes of data they collect during qualitative studies. This paper seeks to pull together much needed resources and provide an overview of methods. A step-by-step guide to planning a qualitative descriptive study and analyzing the data is provided, utilizing exemplars from the authors' research. This paper presents steps to conducting a qualitative descriptive study under the following headings: describing the qualitative descriptive approach, designing a qualitative descriptive study, steps to data analysis, and ensuring rigor of findings. The qualitative descriptive approach results in a summary in everyday, factual language that facilitates understanding of a selected phenomenon across disciplines of health science researchers. © The Author(s) 2016.

  6. Model Experiments and Model Descriptions

    Science.gov (United States)

    Jackman, Charles H.; Ko, Malcolm K. W.; Weisenstein, Debra; Scott, Courtney J.; Shia, Run-Lie; Rodriguez, Jose; Sze, N. D.; Vohralik, Peter; Randeniya, Lakshman; Plumb, Ian

    1999-01-01

    The Second Workshop on Stratospheric Models and Measurements Workshop (M&M II) is the continuation of the effort previously started in the first Workshop (M&M I, Prather and Remsberg [1993]) held in 1992. As originally stated, the aim of M&M is to provide a foundation for establishing the credibility of stratospheric models used in environmental assessments of the ozone response to chlorofluorocarbons, aircraft emissions, and other climate-chemistry interactions. To accomplish this, a set of measurements of the present day atmosphere was selected. The intent was that successful simulations of the set of measurements should become the prerequisite for the acceptance of these models as having a reliable prediction for future ozone behavior. This section is divided into two: model experiment and model descriptions. In the model experiment, participant were given the charge to design a number of experiments that would use observations to test whether models are using the correct mechanisms to simulate the distributions of ozone and other trace gases in the atmosphere. The purpose is closely tied to the needs to reduce the uncertainties in the model predicted responses of stratospheric ozone to perturbations. The specifications for the experiments were sent out to the modeling community in June 1997. Twenty eight modeling groups responded to the requests for input. The first part of this section discusses the different modeling group, along with the experiments performed. Part two of this section, gives brief descriptions of each model as provided by the individual modeling groups.

  7. Addressing the Language Description Deficit

    Directory of Open Access Journals (Sweden)

    M. Ali Bolgiin

    2010-01-01

    Full Text Available Well-described language features are key to successful teaching and learning, especially for achieving advanced levels of proficiency. Other measures, such as simply increasing the number of reading and listening passages in a language program alone are not enough to bring the student to a higher level in a given skill. In fact, even being present in the target culture does not suffice. Angelelli and Degueldre (2002 argue that at advanced levels, even spending time in a country where the language is spoken is not necessarily sufficient for learners: "They do not need just exposure; they need answers to questions and explanations that they can rarely get by simply being immersed in a language/ culture." Less commonly taught languages (LCTLs lack descriptions that have such answers and explanations (cf. Fotos, 2002. It is argued in this paper that corpuslinguistic analyses help to provide actual usage-based, rather than intuition-based, descriptions and explanations of language features. Such approach is illustrated through English and Turkish examples.

  8. Description scheme for video editing work

    Science.gov (United States)

    Ruiloba, Rosa I.; Joly, Philippe

    2001-03-01

    This article presents a Description Scheme (DS) to describe the audio-visual documents from the video editing work point of view. This DS is based on edition techniques used in the video edition domain. The main objective of this DS is to provide a complete, modular and extensible description of the structure of the video documents based on editing process. This VideoEditing DS is generic in the sense that it may be used in a large number of applications such as video document indexing and analysis, description of Edit Decision List and elaboration of editing patterns. It is based on accurate and complete definitions of shots and transition effects required for video document analysis applications. The VideoEditing DS allows three levels of description : analytic, synthetic and semantic. In the DS, the higher (resp. the lower) is the element of description, the more analytic (resp. synthetic) is the information. %Phil This DS allows describing the editing work made by editing boards, using more detailed descriptors of Shots and Transition DSs. These elements are provided to define editing patterns that allow several possible reconstructions of movies depending on, for example, the target audience. A part of the video description made with this DS may be automatically produced by the video to shots segmentation algorithms (analytic DSs ) or by editing software, at the same time the edition work is made. This DS gives an answer to the needs related to the exchange of editing work descriptions between editing softwares. At the same time, the same DS provide an analytic description of editing work which is complementary to existing standards for Edit Decision Lists like SMPTE or AAF.

  9. A reexamination of the North American Crepis agamic complex and comparison with the findings of Babcock and Stebbins' classic biosystematic monograph.

    Science.gov (United States)

    Sears, Christopher J; Whitton, Jeannette

    2016-07-01

    Babcock and Stebbins coined the term agamic complex in their 1938 monograph of the North American Crepis agamic complex. Despite the historical role that this complex holds in the evolutionary literature, it has not been reexamined in over 75 years. We present a thorough reevaluation of the complex to test hypotheses proposed by Babcock and Stebbins about its origins and spread, the relationships of diploids, and the nature and origins of polyploids. We used flow cytometry to infer ploidy of roughly 600 samples spanning the morphological and taxonomic diversity of the complex and a phylogenetic analysis of plastid DNA variation to infer maternal relationships among diploids and to infer maternal origins of polyploids. We identified populations of all seven recognized diploids plus one new lineage. Phylogenetic analysis of plastid DNA variation in diploids revealed a well-resolved, but moderately supported phylogeny, with evidence for monophyly of the North America Crepis agamic complex and no evidence of widespread homoploid hybridization. Polyploids showed evidence of multiple origins and a pattern of frequent local co-occurrence consistent with repeated colonization of suitable sites. Our findings agree broadly with the distribution and variation of ploidy within and among species described by Babcock and Stebbins. One key difference is finding support for monophyly of North American species, and refuting their hypothesis of polyphyly. Our results provide an explicit phylogenetic framework for further study of this classic agamic complex. © 2016 Botanical Society of America.

  10. NTP-CERHR monograph on the potential human reproductive and developmental effects of hydroxyurea.

    Science.gov (United States)

    2008-10-01

    The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for hydroxyurea to cause adverse effects on reproduction and development in humans. Hydroxyurea is a drug used to treat cancer, sickle cell disease, and thalassemia. It is the only treatment for sickle cell disease in children, aside from blood transfusion and, in severe cases, hematopoietic stem cell transplantation. Hydroxyurea is FDA-approved for use in adults with sickle cell anemia to reduce the frequency of painful crises and the need for blood transfusions. Hydroxyurea may be given to children and adults with sickle cell disease for an extended period of time or for repeated cycles of therapy. Treatment with hydroxyurea is associated with known side effects such as cytotoxicity and myelosuppression, and hydroxyurea is genotoxic (can damage DNA). CERHR selected hydroxyurea for evaluation because of: its increasing use for treatment of sickle cell disease in children and adults, knowledge that it inhibits DNA synthesis and is cytotoxic, and published evidence of reproductive and developmental toxicity in rodents. The results of this evaluation are published in the NTP-CERHR Monograph on Hydroxyurea, which includes the NTP Brief and Expert Panel Report on the Reproductive and Developmental Toxicity of Hydroxyurea. Additional information related to the evaluation process, including public comments received on the draft NTP Brief and the final expert panel report, are available on the CERHR website (http:// cerhr.niehs.nih.gov/). See hydroxyurea under "CERHR Chemicals" on the homepage or go directly to http://cerhr.niehs.nih.gov/chemicals/hydroxyurea/hydroxyurea-eval.html). The NTP reached the following conclusions on the possible effects of exposure to hydroxyurea on human reproduction or development. The possible levels of concern, from lowest to highest, are negligible concern, minimal concern, some concern, concern

  11. NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A.

    Science.gov (United States)

    Shelby, Michael D

    2008-09-01

    The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for bisphenol A to cause adverse effects on reproduction and development in humans. The CERHR Expert Panel on Bisphenol A completed its evaluation in August 2007. CERHR selected bisphenol A for evaluation because of the: widespread human exposure; public concern for possible health effects from human exposures; high production volume; evidence of reproductive and developmental toxicity in laboratory animal studies Bisphenol A (CAS RN: 80-05-7) is a high production volume chemical used primarily in the production of polycarbonate plastics and epoxy resins. Polycarbonate plastics are used in some food and drink containers; the resins are used as lacquers to coat metal products such as food cans, bottle tops, and water supply pipes. To a lesser extent bisphenol A is used in the production of polyester resins, polysulfone resins, polyacrylate resins, and flame retardants. In addition, bisphenol A is used in the processing of polyvinyl chloride plastic and in the recycling of thermal paper. Some polymers used in dental sealants and tooth coatings contain bisphenol A. The primary source of exposure to bisphenol A for most people is assumed to occur through the diet. While air, dust, and water (including skin contact during bathing and swimming) are other possible sources of exposure, bisphenol A in food and beverages accounts for the majority of daily human exposure. The highest estimated daily intakes of bisphenol A in the general population occur in infants and children. The results of this bisphenol A evaluation are published in an NTP-CERHR Monograph that includes the (1) NTP Brief and (2) Expert Panel Report on the Reproductive and Developmental Toxicity of Bisphenol A. Additional information related to the evaluation process, including the peer review report for the NTP Brief and public comments received on the draft NTP

  12. [Non-febrile syndromes in the traveler returning from tropical regions admitted in a monographic unit].

    Science.gov (United States)

    Anula-Morales, A; Martin-Giner, B; Hernández-Cabrera, M; Carranza-Rodríguez, C; Pisos-Álamo, E; Jaén-Sánchez, N; Pérez-Arellano, J L

    2017-04-01

    The aim was to analyse those syndromes without fever in travellers who return from tropical regions evaluated at our Department of Infectology and Tropical Medicine. Clarifying these conditions intends to reach earlier diagnoses and, perhaps, to avoid the emergence and spread of imported diseases, as well as to establish appropriate preventive measures. An observational descriptive transversal study was performed, selecting those patients who returned from tropical regions without fever (n = 281), amongst all travellers evaluated in our department between 1998 and 2013. We analysed demographic features, information related to the trip, as well as the presenting complaints and the diagnoses. A total of 281 international travellers presenting without fever were analysed. Only 39% had received health counsel prior to travelling. The most visited regions were Lat-in America (38.8%), Africa (37.8%) and Asia (13.6%). 15% of patients were asymptomatic or suffered from non-infectious conditions. Among the rest, most had either gastrointestinal (46%) or cutaneous (34%) syndromes. The main gastrointestinal condition was diarrhoea, with a microbiological diagnosis reached in almost 50% of cases. Regarding cutaneous syndromes, arthropods bites (31%) and different bacterial lesions (20%) were most common. Approximately 10% of patients in Travel Medicine are international travellers returning from tropical regions, half of them with no fever. Most are diagnosed with infectious diseases, mainly gastrointestinal or cutaneous syn-dromes. Eosinophilia is the third problem in frequency among this group of patients, and sexually transmitted infections are rare in our cohort. It is important to emphasize in preventive activities.

  13. Direction and Description

    Science.gov (United States)

    Ben-Menahem, Yemima

    This paper deals with the dependence of directionality in the course of events-or our claims concerning such directionality-on the modes of description we use in speaking of the events in question. I argue that criteria of similarity and individuation play a crucial role in assessments of directionality. This is an extension of Davidson's claim regarding the difference between causal and explanatory contexts. The argument is based on a characterisation of notions of necessity and contingency that differ from their modal logic counterparts on the one hand, and from causality and chance on the other. I show that some types of directionality are perfectly compatible with both determinism and indeterminism at the microscopic level, and that there is no likelihood of, or advantage to, reducing such directionality to other laws or causal processes.

  14. From description to prescription

    DEFF Research Database (Denmark)

    McQuaid, Sara Dybris

    current prominent position within the academy. Structuring these interpretations alongside evolving constitutional policy, the paper will argue that although consociationalism has developed as an indeterminate research design, the inherent logic of managing diversity on the basis of equality as opposed......From Description to Prescription: Politics of Recognition, Consociational Theory and the Conflict in Northern Ireland. Within academic discourses on Northern Ireland the politics of recognition and particularly the theory of consociational democracy has made a profound impact. First introduced...... by the Dutch political scientist Arend Lijphart in a World Politics article from 1969, it has since increased in importance, both as an authoritative explanatory framework for the institutional design inherent in political agreements and as a desirable approach to manage, balance and potentially dissolve...

  15. 欧盟传统草药专论述评%Review on community herbal monographs for traditional herbal medicinal products

    Institute of Scientific and Technical Information of China (English)

    邹文俊; 瞿礼萍; 叶祖光; 姬建新; 李伯刚

    2011-01-01

    该文通过对欧盟传统草药专论的建立与评价进行深入分析研究,关注传统草药专论的最新进展,阐明欧盟传统草药专论与简化注册的关系,为我国中药产品欧盟注册提供参考.%This article discusses the characteristics of cmmunity herbal monographs for traditional herbal medicinal products and its establishment procedure. It also reviews the new development of cmmunity traditional herbal monographs. The purpose is to clarify the relationship between cmmunity herbal monographs and simplified registration for traditional herbal medicinal product in European Union and provide reference to the registration of taditional Chinese mdicinal products in Europe.

  16. Hypervideos and interactive multimedia presentations

    NARCIS (Netherlands)

    B. Meixner (Britta)

    2017-01-01

    textabstractHypervideos and interactive multimedia presentations allow the creation of fully interactive and enriched video. It is possible to organize video scenes in a nonlinear way. Additional information can be added to the video ranging from short descriptions to images and more videos.

  17. High Luminosity LHC Project Description

    CERN Document Server

    Apollinari, Giorgio; Rossi, Lucio

    2014-01-01

    The High Luminosity LHC (HL-LHC) is a novel configuration of the Large Hadron Collider, aiming at increasing the luminosity by a factor five or more above the nominal LHC design, to allow increasing the integrated luminosity, in the high luminosity experiments ATLAS and CMS, from the 300 fb-1 of the LHC original design up to 3000 fb-1 or more. This paper contains a short description of the main machine parameters and of the main equipment that need to be developed and installed. The preliminary cost evaluation and the time plan are presented, too. Finally, the international collaboration that is supporting the project, the governance and the project structure are discussed, too.

  18. Descriptive data of JENDL-3.2

    Energy Technology Data Exchange (ETDEWEB)

    Shibata, Keiichi; Narita, Tsutomu [eds.] [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-02-01

    The second revision of JENDL-3 (JENDL-3.2) was released in 1994. The library contains evaluated neutron nuclear data for 340 nuclides which are needed for the design of fission and fusion reactors and for shielding calculation. This report presents a brief description of the evaluation method which is given in the File-1 part of JENDL-3.2. (author)

  19. Descriptive data of JENDL-3.3

    Energy Technology Data Exchange (ETDEWEB)

    Shibata, Keiichi (ed.) [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2003-01-01

    The third revision of JENDL-3 (JENDL-3.3) was released in 2002. The library contains evaluated neutron nuclear data for 337 nuclides. This report presents a brief description of the evaluation method which is given in the MF1 part of JENDL-3.3. (author)

  20. Descriptive data of JENDL-3.3

    CERN Document Server

    Shibata, K

    2003-01-01

    The third revision of JENDL-3 (JENDL-3.3) was released in 2002. The library contains evaluated neutron nuclear data for 337 nuclides. This report presents a brief description of the evaluation method which is given in the MF1 part of JENDL-3.3.

  1. Semantic description and recognition of patterns

    Institute of Scientific and Technical Information of China (English)

    杨立; 戴汝为

    1996-01-01

    An algebraic semantic approach for the description and recognition of patterns is presented.Specifically,patterns are assumed as algebraic structures,and semantic constraints are given in the form of equational specifications.By such an idea,to recogniz a pattern is to check the validity of an equational conjecture by term rewriting.Such an approach is demonstrated through examples.

  2. A DESCRIPTIVE INDONESIAN GRAMMAR--PRELIMINARY EDITION.

    Science.gov (United States)

    DYEN, ISIDORE

    THIS PRELIMINARY EDITION COMPRISES A DESCRIPTIVE GRAMMAR OF INDONESIAN (BAHASA INDONESIA), THE OFFICIAL LANGUAGE OF THE REPUBLIC OF INDONESIA. THE THREE SECTIONS--PHONOLOGY, SYNTAX, AND MORPHOLOGY--PRESENT A COMPREHENSIVE LINGUISTIC ANALYSIS OF INDONESIAN, WITH OCCASIONAL CONTRASTIVE REFERENCE TO MALAY, JAVANESE, SUNDANESE, AND SUMATRAN. THIS…

  3. Enriching a Descriptive Grammar with Treebank Queries

    NARCIS (Netherlands)

    Bouma, G.; van Koppen, J.M.|info:eu-repo/dai/nl/203188934; Landsbergen, Frank; Odijk, J.E.J.M.|info:eu-repo/dai/nl/082781710; van der Wouden, Ton; van de Camp, Matje

    2015-01-01

    The Syntax of Dutch (SoD) is a descriptive and detailed grammar of Dutch, that provides data for many issues raised in linguistic theory. We present the results of a pilot project that investigated the possibility of enriching the online version of the text with links to queries that provide

  4. Description of the Wetlands Research Programme

    CSIR Research Space (South Africa)

    Walmsley, RD

    1988-01-01

    Full Text Available This report presents a rationale to the development of a multidisciplinary South African Wetland Research Programme. A definition of what is meant by the term wetland is given along with a general description of what types of wetland occur in South...

  5. [Molluscum contagiosum: descriptive study].

    Science.gov (United States)

    Monteagudo, B; Cabanillas, M; Acevedo, A; de Las Heras, C; Pérez-Pérez, L; Suárez-Amor, O; Ginarte, M

    2010-02-01

    Molluscum contagiosum is a cutaneous viral infection that often requires assistance. The aim of our study is to review the cases admitted in our clinic, evaluate the epidemiological features and the treatment prescribed. We conducted a descriptive survey of the patients diagnosed of molluscum contagiosum in our clinic (Complexo Hospitalario Arquitecto Marcide-Novoa Santos, Ferrol, Spain) between June 16th 2008 and January 15th 2009. The following dates were recorded in all cases: age, sex, personal history of atopy, swimming pool attendance, number of lesions and treatment prescribed. 140 cases of molluscum contagiosum were included in the study. Average age was 10.7 years. 51.43% of patients had a personal history of atopy and 72.1% used to attendance swimming-pool. Average number of lesions was 13.3, with a higher number of them in males, atopic and swimming-pool attendants. Curettage was the treatment performed in 86.4% of cases. Atopic dermatitis and swimming-pool attendance were associated in our study with a higher frequency and number of molluscum contagiosum. Although different therapeutic options must be evaluated depending on the patient and clinical skills, curettage is the most frequent treatment performed by dermatologists.

  6. Inter-laboratory verification of European pharmacopoeia monograph on derivative spectrophotometry method and its application for chitosan hydrochloride.

    Science.gov (United States)

    Marković, Bojan; Ignjatović, Janko; Vujadinović, Mirjana; Savić, Vedrana; Vladimirov, Sote; Karljiković-Rajić, Katarina

    2015-01-01

    Inter-laboratory verification of European pharmacopoeia (EP) monograph on derivative spectrophotometry (DS) method and its application for chitosan hydrochloride was carried out on two generation of instruments (earlier GBC Cintra 20 and current technology TS Evolution 300). Instruments operate with different versions of Savitzky-Golay algorithm and modes of generating digital derivative spectra. For resolution power parameter, defined as the amplitude ratio A/B in DS method EP monograph, comparable results were obtained only with algorithm's parameters smoothing points (SP) 7 and the 2nd degree polynomial and those provided corresponding data with other two modes on TS Evolution 300 Medium digital indirect and Medium digital direct. Using quoted algorithm's parameters, the differences in percentages between the amplitude ratio A/B averages, were within accepted criteria (±3%) for assay of drug product for method transfer. The deviation of 1.76% for the degree of deacetylation assessment of chitosan hydrochloride, determined on two instruments, (amplitude (1)D202; the 2nd degree polynomial and SP 9 in Savitzky-Golay algorithm), was acceptable, since it was within allowed criteria (±2%) for assay deviation of drug substance, for method transfer in pharmaceutical analyses. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. Microcanonical Description of (Micro Black Holes

    Directory of Open Access Journals (Sweden)

    Benjamin Harms

    2011-02-01

    Full Text Available The microcanonical ensemble is the proper ensemble to describe black holes which are not in thermodynamic equilibrium, such as radiating black holes. This choice of ensemble eliminates the problems, e.g., negative specific heat (not allowed in the canonical ensemble and loss of unitarity, encountered when the canonical ensemble is used. In this review we present an overview of the weaknesses of the standard thermodynamic description of black holes and show how the microcanonical approach can provide a consistent description of black holes and their Hawking radiation at all energy scales. Our approach is based on viewing the horizon area as yielding the ensemble density at fixed system energy. We then compare the decay rates of black holes in the two different pictures. Our description is particularly relevant for the analysis of micro-black holes whose existenceis predicted in models with extra-spatial dimensions.

  8. CONDOR-CITVAP-MCNP calculation line description

    Energy Technology Data Exchange (ETDEWEB)

    Villarino, Eduardo Anibal [INVAP S.E., San Carlos de Bariloche (Argentina)

    2002-07-01

    A general description of the CONDOR-CITVAP-MCNP calculation line is given. This calculation line starts at cross section library and allows burnup dependent detailed calculation using MCNP. This calculation line is divided in two main methodologies: CONDOR-CITVAP that allows the 3-Dimensional core burnup calculation and MCNP that performs detailed transport calculations, both methodologies are coupled using the NDDUMP code. A short description of the used codes are given: CONDOR code performs the cell calculation, generating burnup dependent macroscopic cross section and burnup dependent numerical densities per material. CITVAP codes perform the burnup dependent core calculation, including the fuel management and calculates the burnup distribution per material. NDDUMP code generates materials burnup dependent numerical densities to be used by MCNP code. This paper presents a detailed description of the CONDOR-CITVAP-MCNP calculation line and a numerical comparison of the proposed methodology. (author)

  9. A New Topological Description Method of Kinematic Chain

    Institute of Scientific and Technical Information of China (English)

    Ding Huafeng; Huang Zhen; Cao Yi

    2004-01-01

    This paper presents a novel method for the description of kinematic chains, namely the canonical description of kinematic chains including the synthetic degree-sequences and the canonical adjacency matrices sets of kinematic chains. The most important characteristic of this new description method is its uniqueness. Based on the new principle the isomorphism identification becomes easy and the structures of all kinds of kinematic chains can be stored in computer for the benefits of the realization of automation and intelligence of machine design.

  10. Trusting Description: Authenticity, Accountability, and Archival Description Standards

    Science.gov (United States)

    MacNeil, Heather

    2009-01-01

    It has been suggested that one of the purposes of archival description is to establish grounds for presuming the authenticity of the records being described. The article examines the implications of this statement by examining the relationship between and among authenticity, archival description, and archival accountability, assessing how this…

  11. Multiple Descriptions Using Sparse Decompositions

    DEFF Research Database (Denmark)

    Jensen, Tobias Lindstrøm; Østergaard, Jan; Dahl, Joachim;

    2010-01-01

    and furthermore are able to refine each other. In this paper, we form descriptions using convex optimization with l1-norm minimization and Euclidean distortion constraints on the reconstructions and show that with this method we can obtain non-trivial descriptions. We give an algorithm based on recently developed...

  12. Software Architecture Description and UML

    NARCIS (Netherlands)

    Avgeriou, Paris; Guelfi, Nicolas; Medvidovic, Nenad

    2005-01-01

    The description of software architectures has always been concerned with the definition of the appropriate languages for designing the various architectural artifacts. Over the past ten years, formal or less formal Architecture Description Languages (ADLs) and supporting methods and tools have been

  13. Combine harvester : threshing process description

    DEFF Research Database (Denmark)

    Carton, Denis Manuel

    1999-01-01

    The harvest consists of two mains opertions : cutting the crop and extracting the grain.This report is a general description of a model for this mechanism.......The harvest consists of two mains opertions : cutting the crop and extracting the grain.This report is a general description of a model for this mechanism....

  14. Psychotherapy and Counseling in the Treatment of Drug Abuse [Technical Review] (Rockville, Maryland, May 18-19, 1989). National Institute on Drug Abuse Research Monograph Series 104.

    Science.gov (United States)

    Onken, Lisa Simon; Blaine, Jack D.

    This monograph is based on the papers from a technical review. These papers are included: (1) Psychotherapy and Counseling Research in Drug Abuse Treatment: Questions, Problems, and Solutions (Lisa Onken, Jack Blaine); (2) Psychotherapy and Counseling for Methadone-Maintained Opiate Addicts: Results of Research Studies (George Woody, A. T.…

  15. A monograph of the fern Genus Microsorum (Polypodiaceae) including an attempt towards a reconstruction of the phylogenetic history of the microsoroids

    NARCIS (Netherlands)

    Bosman, M.T.M.

    1991-01-01

    This revision is a monographic treatment of the fern genus Microsorum (Polypodiaceae). To elucidate the problematic generic delimitation and systematic position of this genus an additional selection of 26 possibly related species was also studied. Most of these related species are traditionally plac

  16. Bullying and School Attendance: A Case Study of Senior High School Students in Ghana. CREATE Pathways to Access. Research Monograph No. 41

    Science.gov (United States)

    Dunne, Mairead; Bosumtwi-Sam, Cynthia; Sabates, Ricardo; Owusu, Andrew

    2010-01-01

    This monograph analyses the effects of bullying on school attendance among senior high school students in Ghana. A strong correlation is found between being bullied and having poor attendance. The effects of emotional problems and of peer friendships on this correlation are then examined. For both boys and girls, having emotional problems is…

  17. Writing on Your Feet: Reflective Practices in City as Text™. A Tribute to the Career of Bernice Braid. National Collegiate Honors Council Monograph Series

    Science.gov (United States)

    Long, Ada, Ed.

    2014-01-01

    City as Text™ (CAT) is one of the earliest structural forms of experiential learning created and practiced in the United States. This monograph explores the centrality of writing in the process of active learning, focusing primarily on the Faculty Institutes and Honors Semesters that foster CAT experiences. All manifestations of this pedagogical…

  18. What Do They Use? Where Do They Get It? An Interdisciplinary Citation Analysis of Latin American Studies Faculty Monographs, 2004-2013

    Science.gov (United States)

    Ostos, Manuel

    2017-01-01

    This citation analysis examines the ability of the local collection at the Pennsylvania State University to meet the needs of global and area studies researchers focusing on monographs published by faculty members on Latin American studies in a ten-year period. The study focuses on book use to address the tempting notion that packages and online…

  19. Comparing Linear Relationships between E-Book Usage and University Student and Faculty Populations: The Differences between E-Reference and E-Monograph Collections

    Science.gov (United States)

    Lamothe, Alain R.

    2013-01-01

    This paper reports the results from a quantitative study examining the strength of linear relationships between Laurentian University students and faculty members and the J. N. Desmarais Library's reference and monograph e-book collections. The number of full-text items accessed, searches performed, and undergraduate, graduate, and faculty…

  20. The Economic Value of Breastfeeding (With Results from Research Conducted in Ghana and the Ivory Coast). Cornell International Nutrition Monograph Series Number 6.

    Science.gov (United States)

    Greiner, Ted; And Others

    This monograph focuses attention on economic considerations related to infant feeding practices in developing countries. By enlarging on previous methodologies, this paper proposes to improve the accuracy of past estimates of the economic value of human milk, or more specifically, the practice of breastfeeding. The theoretical model employed…

  1. The Decline in Breastfeeding: An Analysis of the Role of the Nestle Corporation from Two Perspectives. Cornell International Nutrition Monograph Series, Number 11 (1982).

    Science.gov (United States)

    Campbell, Carolyn E.

    An attempt is made to analyze the ascendancy of formula feeding of infants in terms of the conflicting ideologies of Marxism and capitalism. The decline of breastfeeding is traced, and is linked with the interrelated phenomena of free market economics and the domination of women by men in Western society. The monograph has two sections:…

  2. The Law of Procedure in Student Suspensions and Expulsions. NOLPE Monograph Series. ERIC/CEM State-of-the-Knowledge Series, Number Thirty-four.

    Science.gov (United States)

    Phay, Robert E.

    This state-of-the-knowledge paper, a companion to the author's 1975 monograph on a similar topic, examines the legal ramifications of student suspension, expulsion, and search and seizure of students' property. The author reviews relevant court litigation and state laws pertaining to specific rules on student conduct, the procedures to follow in…

  3. School Administrators and the Courts: A Review of Recent Decisions. ERS Monograph. Series, No. 3. ERIC/CEM State-of-the-Knowledge Series, No. 30.

    Science.gov (United States)

    Hudgins, H. C., Jr.

    This monograph is a review of selected judicial decisions reported by state and federal courts during the past two years and related directly to the administration of elementary or secondary schools. The decisions were identified through a standard search of legal resources at the Temple University Law Library; each decision was read in its…

  4. The Economic Value of Breastfeeding (With Results from Research Conducted in Ghana and the Ivory Coast). Cornell International Nutrition Monograph Series Number 6.

    Science.gov (United States)

    Greiner, Ted; And Others

    This monograph focuses attention on economic considerations related to infant feeding practices in developing countries. By enlarging on previous methodologies, this paper proposes to improve the accuracy of past estimates of the economic value of human milk, or more specifically, the practice of breastfeeding. The theoretical model employed…

  5. Adult Education in the Federal Republic of Germany: Scholarly Approaches and Professional Practice. Monographs on Comparative and Area Studies in Adult Education.

    Science.gov (United States)

    Mader, Wilhelm, Ed.

    This monograph offers insight into the development of the conceptual basis, scholarly inquiry, and professional practice of adult education in West Germany from the end of World War II to the German reunification. Introductory materials are an "Introduction" (Wilhelm Mader) and "Translator's Note and Acknowledgements" (Martin…

  6. Comparing Linear Relationships between E-Book Usage and University Student and Faculty Populations: The Differences between E-Reference and E-Monograph Collections

    Science.gov (United States)

    Lamothe, Alain R.

    2013-01-01

    This paper reports the results from a quantitative study examining the strength of linear relationships between Laurentian University students and faculty members and the J. N. Desmarais Library's reference and monograph e-book collections. The number of full-text items accessed, searches performed, and undergraduate, graduate, and faculty…

  7. Corrections and Juvenile Justice: Current Education Practice for Youth with Learning and Other Disabilities. Monograph Series on Education, Disability and Juvenile Justice.

    Science.gov (United States)

    Howell, Kenneth W.; Wolford, Bruce I.

    This monograph, one of a series on youth with disabilities and the juvenile justice system, focuses on the educational services provided to youth with behavioral and cognitive disabilities placed in the juvenile justice system. It reports on a review of correctional system monitoring reports, materials from enforcement actions taken against…

  8. Descriptions of Earthworms

    NARCIS (Netherlands)

    Horst, R.

    1890-01-01

    Among the animals, collected by Dr. A. Vorderman in the island of Billiton 1) and presented to our Museum, I met with some earthworms belonging to the genus Perichaeta, which appear to be hitherto undescribed.

  9. Appendiceal taeniasis presenting like acute appendicitis.

    Science.gov (United States)

    Sartorelli, Alesso Cervantes; da Silva, Márcia Guimarães; Rodrigues, Maria Aparecida Marchesan; da Silva, Reinaldo José

    2005-09-01

    A case of parasitic appendicitis caused by Taenia sp. in a 28-year-old woman from Brazil is reported. Histopathological data and a description of the helminthe found in the appendix lumen are presented.

  10. Investigation on several monographs of the Tang dynasty related to Lingnan (Southern Tidges) medicine%唐代几部有关岭南医药专著的考察

    Institute of Scientific and Technical Information of China (English)

    靳士英; 靳朴

    2008-01-01

    、、共著录8部唐代有关岭南的医药专著,至元、明时全佚.今桂林南溪山有宋人摩崖石刻一通;中有、各一条,是唐人郑景岫迄今仅有的遗存.唐代有关南药、海药的专著,有未著撰人的和李珣,李时珍认为两者为一书.今查发现,有一药引一书者,有一药同时引两书者,内容不同,疑为两书.%In the Tang dynasty,eight monographs related to Lingnan medicine were recorded in Yi wen zhi (Bibliography of Arts and Literature) of Xin tang shu (Annals of New Tang Dynasty),Yi wen liie (Brief Bibliography of Arts had Literature) of Tong zhi liie(Brief Annals of General History),Yi wen zhi (Bibliography of Arts and Literature) of Song shi (Annals of Song Dynasty).However,all of them were lost in the Yuan and Ming dynasty.Now,a piece of stone-carving,Gnang nan she sheng lun yang qi tang fang (Nourishing Qi Prescription of Treatise of Keeping Health of Guangnan) was found at the cliff on Nanxi Mountain in Guilin,the descriptions about keeping health prescription and keeping health treatise in Ling nan wei sheng fang (Hygiene Prescriptions of Southern Ridges) were regarded as the only extant version of Guang nan she sheng lun (Treatise of Keeping Health of Guangnan) written by Zheng Jing-xiu in the Tang Dynasty.Monographs about southern Chinese medicines and oversea medicines in the Tang dynasty can be seen,such as Nan hai yao pu (Prescriptions of Nanhai) written by anonymous author and Li Xun's Hai yao ben cao (Oversea Materia Medica).Both claimed by Li Shi-zhen to be the same book.Now,after checking the Zheng he ben cao (Materia Medica of Zhenghe Reign),it is suspicious that these are two different books instead of one,because sometimes,one medicinal item is quoted from one source,while other item can be quoted from the both sourees at the same time with different contexts.

  11. Towards reproducible descriptions of neuronal network models.

    Directory of Open Access Journals (Sweden)

    Eilen Nordlie

    2009-08-01

    Full Text Available Progress in science depends on the effective exchange of ideas among scientists. New ideas can be assessed and criticized in a meaningful manner only if they are formulated precisely. This applies to simulation studies as well as to experiments and theories. But after more than 50 years of neuronal network simulations, we still lack a clear and common understanding of the role of computational models in neuroscience as well as established practices for describing network models in publications. This hinders the critical evaluation of network models as well as their re-use. We analyze here 14 research papers proposing neuronal network models of different complexity and find widely varying approaches to model descriptions, with regard to both the means of description and the ordering and placement of material. We further observe great variation in the graphical representation of networks and the notation used in equations. Based on our observations, we propose a good model description practice, composed of guidelines for the organization of publications, a checklist for model descriptions, templates for tables presenting model structure, and guidelines for diagrams of networks. The main purpose of this good practice is to trigger a debate about the communication of neuronal network models in a manner comprehensible to humans, as opposed to machine-readable model description languages. We believe that the good model description practice proposed here, together with a number of other recent initiatives on data-, model-, and software-sharing, may lead to a deeper and more fruitful exchange of ideas among computational neuroscientists in years to come. We further hope that work on standardized ways of describing--and thinking about--complex neuronal networks will lead the scientific community to a clearer understanding of high-level concepts in network dynamics, and will thus lead to deeper insights into the function of the brain.

  12. Postcolonial Times: Lock the Gate or Pull Down the Fences? A special Monograph Edition

    Directory of Open Access Journals (Sweden)

    Bill Boyd

    2013-06-01

    understands but that does not actually express what you mean, or speak your own language and risk the other party not understanding what you mean. Copyright © Bill Boyd 2013. This text may be archived and redistributed both in electronic form and in hard copy, provided that the author and journal are properly cited and no fee is charged. Coolabah, No.12, 2013, ISSN 1988-5946, Observatori: Centre d’Estudis Australians, Australian Studies Centre, Universitat de Barcelona 2 From a postcolonial studies perspective, this example reminds students of two key processes. First, students need to master the intellectual skills of the humanities in order to provide critical analysis of social situations. Secondly, students need to know that, as western scholars, they are as much part of any postcolonial problem as those in power, and therefore need to develop good reflective skills and to learn to think ‘otherwise’. This invited monograph is the text of the lecture, supplemented with further comments and illustrations, delivered to second year Humanities students at the University of Barcelona, Catalonia, on Monday 8th April 2013

  13. The Fundamental Scale of Descriptions

    CERN Document Server

    Febres, Gerardo

    2014-01-01

    The complexity of a system description is a function of the entropy of its symbolic description. Prior to computing the entropy of the system description, an observation scale has to be assumed. In natural language texts, typical scales are binary, characters, and words. However, considering languages as structures built around certain preconceived set of symbols, like words or characters, is only a presumption. This study depicts the notion of the Description Fundamental Scale as a set of symbols which serves to analyze the essence a language structure. The concept of Fundamental Scale is tested using English and MIDI music texts by means of an algorithm developed to search for a set of symbols, which minimizes the system observed entropy, and therefore best expresses the fundamental scale of the language employed. Test results show that it is possible to find the Fundamental Scale of some languages. The concept of Fundamental Scale, and the method for its determination, emerges as an interesting tool to fac...

  14. Labour: A Prospective, Descriptive Study

    African Journals Online (AJOL)

    Symphysis Fundus Height Measurements during Labour: A Prospective, Descriptive Study 49. Introduction ... 800g in about 50% of cases,2 and in term preg- nancies to be as .... Discussion. Prematurity and low birthweight are major causes.

  15. Description of dose response curve

    OpenAIRE

    Al-Samarai, Firas

    2011-01-01

    The book included several methods to estimate LD50, in addition to explain how to use several programs to estimate LD50. Moreover the book illustrate the description of the dose response curves. Firas Al-Samarai

  16. Back Bay Wilderness area description

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is a description of the lands located within the Back Bay National Wildlife Refuge. Within these lands, it designates which area is suitable for...

  17. Detector Description Framework in LHCb

    CERN Document Server

    Ponce, Sébastien

    2003-01-01

    The Gaudi architecture and framework are designed to provide a common infrastructure and environment for simulation, filtering, reconstruction and analysis applications. In this context, a Detector Description Service was developed in LHCb in order to also provide easy and coherent access to the description of the experimental apparatus. This service centralizes every information about the detector, including geometry, materials, alignment, calibration, structure and controls. From the proof of concept given by the first functional implementation of this service late 2000, the Detector Description Service has grown and has become one of the major components of the LHCb software, shared among all applications, including simulation, reconstruction, analysis and visualization. We describe here the full and functional implementation of the service. We stress the easiness of customization and extension of the detector description by the user, on the seamless integration with condition databases in order to handle ...

  18. Two complementary descriptions of intermittency

    CERN Document Server

    Balkovsky, E

    1998-01-01

    We describe two complementary formalisms designed for the description of probability density function (PDF) of the gradients of turbulent fields. The first approach, we call it adiabatic, describes PDF at the values much less than dispersion. The second, instanton, approach gives the tails of PDF at the values of the gradient much larger than dispersion. Together, both approaches give satisfactory description of gradient PDFs, as illustrated here by an example of a passive scalar advected by a one-dimensional compressible random flow.

  19. Lagrangian description of nonlinear chromatography

    Institute of Scientific and Technical Information of China (English)

    LIANG Heng; LIU Xiaolong

    2004-01-01

    Under the framework of non-equilibrium thermodynamic separation theory (NTST), Local Lagrangian approach (LLA) was proposed to deal with the essential issues of the convection and diffusion (shock waves) phenomena in nonlinear chromatography with recursion equations based on the three basic theorems, Lagrangian description, continuity axiom and local equilibrium assumption (LEA). This approach remarkably distinguished from the system of contemporary chromatographic theories (Eulerian description-partial differential equations), and can felicitously match modern cybernetics.

  20. Minimum Description Length Shape and Appearance Models

    DEFF Research Database (Denmark)

    Thodberg, Hans Henrik

    2003-01-01

    The Minimum Description Length (MDL) approach to shape modelling is reviewed. It solves the point correspondence problem of selecting points on shapes defined as curves so that the points correspond across a data set. An efficient numerical implementation is presented and made available as open s...... source Matlab code. The problems with the early MDL approaches are discussed. Finally the MDL approach is extended to an MDL Appearance Model, which is proposed as a means to perform unsupervised image segmentation....

  1. Wavelet description of the Glottal Gap

    OpenAIRE

    Gómez Vilda, Pedro; Nieto Lluis, Victor; Rodellar Biarge, M. Victoria; Martínez Olalla, Rafael; Muñoz Mulas, Cristina Elena; Álvarez Marquina, Agustin; Mazaira Fernández, Luis Miguel; Scola Yurrita, Bartolomé; Ramírez Calvo, Carlos; Poletti Serafini,Daniel

    2013-01-01

    The Glottal Source correlates reconstructed from the phonated parts of voice may render interesting information with applicability in different fields. One of them is defective closure (gap) detection. Through the paper the background to explain the physical foundations of defective gap are reviewed. A possible method to estimate defective gap is also presented based on a Wavelet Description of the Glottal Source. The method is validated using results from the analysis of a gender-balanced sp...

  2. Forsmark - site descriptive model version 0

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-10-01

    During 2002, the Swedish Nuclear Fuel and Waste Management Company (SKB) is starting investigations at two potential sites for a deep repository in the Precambrian basement of the Fennoscandian Shield. The present report concerns one of those sites, Forsmark, which lies in the municipality of Oesthammar, on the east coast of Sweden, about 150 kilometres north of Stockholm. The site description should present all collected data and interpreted parameters of importance for the overall scientific understanding of the site, for the technical design and environmental impact assessment of the deep repository, and for the assessment of long-term safety. The site description will have two main components: a written synthesis of the site, summarising the current state of knowledge, as documented in the databases containing the primary data from the site investigations, and one or several site descriptive models, in which the collected information is interpreted and presented in a form which can be used in numerical models for rock engineering, environmental impact and long-term safety assessments. The site descriptive models are devised and stepwise updated as the site investigations proceed. The point of departure for this process is the regional site descriptive model, version 0, which is the subject of the present report. Version 0 is developed out of the information available at the start of the site investigation. This information, with the exception of data from tunnels and drill holes at the sites of the Forsmark nuclear reactors and the underground low-middle active radioactive waste storage facility, SFR, is mainly 2D in nature (surface data), and is general and regional, rather than site-specific, in content. For this reason, the Forsmark site descriptive model, version 0, as detailed in the present report, has been developed at a regional scale. It covers a rectangular area, 15 km in a southwest-northeast and 11 km in a northwest-southeast direction, around the

  3. Polemic and Descriptive Negations

    DEFF Research Database (Denmark)

    Horslund, Camilla Søballe

    2011-01-01

    as such may be more or less central to the meaning of the utterance. The present paper investigates the role of morphosyntactic and prosodic prominence as well as register and social setting on the interpretation of negations. It seems plausible to expect that if the negation as such is central to the meaning...... common in certain social context or genres, while polemic negations are more likely to come up in other genres and social settings. Previous studies have shown a relation between articulatory prominence and register, which may further inform the analysis. Hence, the paper investigates how articulatory...... prominence and register may either work in concert or oppose each other with respect to the cues they provide for the interpretation....

  4. Towards unification of product and enterprise system descriptions

    CSIR Research Space (South Africa)

    Erasmus, J

    2015-06-01

    Full Text Available An argument is presented for the unification of descriptions of product systems and enterprise systems. Product systems are developed and produced by enterprises, thus forming an integral part of the enterprise's architecture. However, many products...

  5. Simpevarp - site descriptive model version 0

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-11-01

    During 2002, SKB is starting detailed investigations at two potential sites for a deep repository in the Precambrian rocks of the Fennoscandian Shield. The present report concerns one of those sites, Simpevarp, which lies in the municipality of Oskarshamn, on the southeast coast of Sweden, about 250 kilometres south of Stockholm. The site description will have two main components: a written synthesis of the site, summarising the current state of knowledge, as documented in the databases containing the primary data from the site investigations, and one or several site descriptive models, in which the collected information is interpreted and presented in a form which can be used in numerical models for rock engineering, environmental impact and long-term safety assessments. SKB maintains two main databases at the present time, a site characterisation database called SICADA and a geographic information system called SKB GIS. The site descriptive model will be developed and presented with the aid of the SKB GIS capabilities, and with SKBs Rock Visualisation System (RVS), which is also linked to SICADA. The version 0 model forms an important framework for subsequent model versions, which are developed successively, as new information from the site investigations becomes available. Version 0 is developed out of the information available at the start of the site investigation. In the case of Simpevarp, this is essentially the information which was compiled for the Oskarshamn feasibility study, which led to the choice of that area as a favourable object for further study, together with information collected since its completion. This information, with the exception of the extensive data base from the nearby Aespoe Hard Rock Laboratory, is mainly 2D in nature (surface data), and is general and regional, rather than site-specific, in content. Against this background, the present report consists of the following components: an overview of the present content of the databases

  6. A Unified Semantic Framework for the description of assistive technologies.

    Science.gov (United States)

    Konstadinidou, Aggeliki; Kaklanis, Nikolaos; Votis, Konstantinos; Tzovaras, Dimitrios

    2015-01-01

    This paper presents the Semantic Alignment Tool, a unified, classified, ontological framework, for the description of assistive solutions that comprises information from different sources automatically. The Semantic Alignment Tool is a component of the Cloud4All/GPII infrastructure that enables users to add and/or modify descriptions of assistive technologies and align their specific settings with similar settings in an ontological model based on ISO 9999. The current work presents the interaction of the Semantic Alignment Tool with external sources that contain descriptions and metadata for Assistive Technologies (ATs) in order to achieve their synchronization in the same semantic model.

  7. Semantic matchmaking with nonmonotonic description logics

    CERN Document Server

    Grimm, S

    2009-01-01

    Semantic web has grown into a mature field of research. Its methods find innovative applications on and off the World Wide Web. Its underlying technologies have significant impact on adjacent fields of research and on industrial applications. This new book series reports on the state-of-the-art in foundations, methods, and applications of semantic web and its underlying technologies. It is a central forum for the communication of recent developments and comprises research monographs, textbooks and edited volumes on all topics related to the semantic web. In this first volume several non-monoto

  8. A Modal Description of Multiport Antennas

    Directory of Open Access Journals (Sweden)

    Jonathan J. Lynch

    2011-01-01

    Full Text Available This paper presents a modal description of multiport antennas that leads directly to a rigorous network representation and simple quadratic expressions for gain, efficiency, and effective area. The analysis shows that the transmitting and receiving properties of an element antenna array are exactly described by a 2×2 element scattering matrix together with a set of orthonormal mode functions and accounts for effects such as mutual coupling, scattering, reflection, and losses. The approach is quite general, only requiring that the antenna be finite and reciprocal. The scattering network description simplifies accounting of power flow while retaining a close connection to the physical antenna characteristics. The orthonormal mode functions provide a complete basis for radiated and received fields, facilitating beamforming. The theory provides rigorous definitions of input-output signals and links them to the underlying electromagnetics in a straightforward manner.

  9. A Corpus-Based Investigation of Definite Description Use

    CERN Document Server

    Poesio, M; Poesio, Massimo; Vieira, Renata

    1997-01-01

    We present the results of a study of definite descriptions use in written texts aimed at assessing the feasibility of annotating corpora with information about definite description interpretation. We ran two experiments, in which subjects were asked to classify the uses of definite descriptions in a corpus of 33 newspaper articles, containing a total of 1412 definite descriptions. We measured the agreement among annotators about the classes assigned to definite descriptions, as well as the agreement about the antecedent assigned to those definites that the annotators classified as being related to an antecedent in the text. The most interesting result of this study from a corpus annotation perspective was the rather low agreement (K=0.63) that we obtained using versions of Hawkins' and Prince's classification schemes; better results (K=0.76) were obtained using the simplified scheme proposed by Fraurud that includes only two classes, first-mention and subsequent-mention. The agreement about antecedents was al...

  10. Generic-Model-Based Description Scheme for MPEG-7

    Institute of Scientific and Technical Information of China (English)

    Deng Juan; Tan Hut; Chen Xin-meng

    2004-01-01

    We propose a new description scheme for MPEG7-: Generic-model-based Description Scheme to describe contents of audio, video, text and other sorts of multimedia.It uses a generic model as the description frame, which provides a simple but useful object-based structure. The main components of the description scheme are generic model, objects and object fcatures. The proposed description scheme is illustrated and exemplified by Extensible Markup Language.It aims at clarity and flexibility to support MPEG-7 applications such as query and edit. We demonstrate its feasibility and efficiency by presenting applications: Digital Broadcasting and Edit System (DEBS) and Non-linear Edit System (NLES) that already used the generic structure or will greatly benefit from it.

  11. Dynamic description logic model for data integration

    Institute of Scientific and Technical Information of China (English)

    Guoshun HAO; Shilong MA; Yuefei SUI; Jianghua LV

    2008-01-01

    Data integration is the issue of retrieving and combining data residing at distributed and heterogeneous sources,and of providing users with transparent access without being aware of the details of the sources.Data integration is a very important issue because it deals with data infrastructure issues of coordinated computing systems.Despite its importance,the following key challenges make data integration one of the longest standing problems around:1) how to solve the system heterogeneity;2) how to build a global model;3) how to process queries automatically and correctly;and 4) how to solve semantic heterogeneity. This paper presents an extended dynamic description logic language to describe systems with dynamic actions.By this language,a-universal and unified model for relational database systems and a model for data integration are presented.This paper presents a universal and unified description logic model for relational databases.The model is universal because any relational database system can be automatically transformed to the model;it is unified because it integrates three essential components of relational databases together:description logic knowledge bases modeling the relational data,atomic modalities modeling the atomic relational operations,and combined modalities modeling the combined relational operations-queries. Furthermore,a description logic model for data integration is proposed which contains four layers of ontologies.Based on the model,a solution for each key challenge is proposed:a universal model eliminates system heterogeneity;a novel global model including three ontologies is proposed with some important benefits;a query process mechanism is provided by which user queries can be decomposed to queries over the sources;and for solving the semantic heterogeneity,this paper provides a framework under which semantic relations can be expressed and inferred. In summary,this paper presents a dynamic knowledge base framework by an extended

  12. MEDLINE收录的高压氧医学专题论文著者群研究%Author distribution of monographic papers on HBO in MEDLIN

    Institute of Scientific and Technical Information of China (English)

    王侠; 甘辉亮; 吕传禄

    2009-01-01

    Objective Through statistical analyses of the distribution characteristics of international monographers on hyperbaric oxygenation,collected by MEDLINE (1998 -2007 ),the number of monographs from 60 countries was compared and analyzed.With the above work done,the most important corporate authors and core authors were identified.%通过对MEDLINE(1998-2007)收录的国际高压氧医学专题论文著者分布特征进行统计分析,对比研究了60个国家的高压氧医学专题论文发表情况,确定了国际高压氧医学研究中高产机构和核心著者.

  13. Memory materials: a unifying description

    Directory of Open Access Journals (Sweden)

    Massimiliano Di Ventra

    2011-12-01

    Full Text Available There are so many materials properties leading to memory that a unifying description seems impossible. However, it is easy to show that the majority of two-terminal electronic devices based on memory materials and systems, when subject to time-dependent perturbations, behave simply as, or as a combination of, memristors, memcapacitors, and meminductors; namely non-linear circuit elements with memory. This unifying description opens up new venues for digital and analog applications ranging from information storage to biologically-inspired circuits. In this review, interesting research opportunities that emerge from this new perspective will be outlined.

  14. Molecular phylogeny, biogeography, and an e-monograph of the papaya family (Caricaceae) as an example of taxonomy in the electronic age

    OpenAIRE

    Antunes Carvalho, Fernanda

    2014-01-01

    This dissertation addresses an issue of key importance to the field of systematics, namely how to foster taxonomic work and the dissemination of knowledge about species by taking full advantage of electronic data and bioinformatic tools. I tested and applied modern systematic tools to produce an electronic monograph of a family of flowering plants, Caricaceae. In addition to a taxonomic revision, a molecular phylogeny of the family that includes representatives of all biological species clari...

  15. 浅谈如何提高科技类学术专著原稿的质量%How to Improve the Tech Academic Monographs Original Quality

    Institute of Scientific and Technical Information of China (English)

    李兰英

    2014-01-01

    Tech academic monographs originals there is often a variety of problems, this paper analyzes the various issues manifestations, causes, and proposed solutions.%科技类学术专著原稿常常存在各种各样的问题,本文分析了各类问题的表现形式、产生的原因,并提出了解决措施。

  16. COG Software Architecture Design Description Document

    Energy Technology Data Exchange (ETDEWEB)

    Buck, R M; Lent, E M

    2009-09-21

    This COG Software Architecture Design Description Document describes the organization and functionality of the COG Multiparticle Monte Carlo Transport Code for radiation shielding and criticality calculations, at a level of detail suitable for guiding a new code developer in the maintenance and enhancement of COG. The intended audience also includes managers and scientists and engineers who wish to have a general knowledge of how the code works. This Document is not intended for end-users. This document covers the software implemented in the standard COG Version 10, as released through RSICC and IAEA. Software resources provided by other institutions will not be covered. This document presents the routines grouped by modules and in the order of the three processing phases. Some routines are used in multiple phases. The routine description is presented once - the first time the routine is referenced. Since this is presented at the level of detail for guiding a new code developer, only the routines invoked by another routine that are significant for the processing phase that is being detailed are presented. An index to all routines detailed is included. Tables for the primary data structures are also presented.

  17. The equilibrium theory of inhomogeneous polymers (international series of monographs on physics)

    CERN Document Server

    Fredrickson, Glenn

    2013-01-01

    The Equilibrium Theory of Inhomogeneous Polymers provides an introduction to the field-theoretic methods and computer simulation techniques that are used in the design of structured polymeric fluids. By such methods, the principles that dictate equilibrium self-assembly in systems ranging from block and graft copolymers, to polyelectrolytes, liquid crystalline polymers, and polymer nanocomposites can be established. Building on an introductory discussion of single-polymer statistical mechanics, the book provides a detailed treatment of analytical and numerical techniques for addressing the conformational properties of polymers subjected to spatially-varying potential fields. This problem is shown to be central to the field-theoretic description of interacting polymeric fluids, and models for a number of important polymer systems are elaborated. Chapter 5 serves to unify and expound the topic of self-consistent field theory, which is a collection of analytical and numerical techniques for obtaining solutions o...

  18. A dose-response study in animals to evaluate the anticoagulant effect of the stage 2 unfractionated heparin USP monograph change.

    Science.gov (United States)

    Honchel, R; Carraway, J; Gopee, N; Callicott, R; Chen, J; Patton, R; Xu, Q; Zalkkar, J; Laniyonu, A; Krefting, I; Cato, M; Robie-Suh, K; Rieves, R

    2011-08-01

    The United States Pharmacopeia (USP) monograph for unfractionated heparin (UFH) was revised in October 2009. This revision was anticipated, based upon in vitro tests, to reduce UFH potency by approximately 10%. To study the potential in vivo consequences of the monograph change, we evaluated activated partial thromboplastin time (aPTT) and activated clotting time (ACT) responses in animals. Female mini-pigs and monkeys (n=8/species) were administered intravenously 60, 54, 48, or 42 U/kg and 50, 45, 40, or 35 U/kg "old" (pre-USP revision) UFH, respectively, in a Williams 4×4 crossover design. Blood samples for aPTT and ACT were collected at 15 min after dosing. The same study design was then repeated using "new" (post-USP revision) UFH. Mean "new" UFH aPTT and ACT values were generally lower than those for "old" UFH although individual animal responses varied considerably. The aPTT and ACT response was generally dose-proportional for both "old" and "new" UFH. These studies indicate that the USP monograph alteration for UFH may result in a modest reduction in the anticoagulant response across a population, but the variability in animal responses underscores the importance of individualization of clinical UFH dosing and the importance of anticoagulant test monitoring. Published by Elsevier Inc.

  19. Exclusion Statistics: a Generalized Description

    Institute of Scientific and Technical Information of China (English)

    WANG Bao-Quan; WANG Yu-Peng

    2005-01-01

    @@ By constructing the fused-particle representation of the free boson gas, we propose a description of the exclusion statistics which allows us to connect the Bose-Einstein statistics and the Fermi-Dirac statistics smoothly.With an proper choice of the exclusion factors γl, Hadane-Wu's fractional statistics is retrieved in this representation.

  20. Natural Language Description of Emotion

    Science.gov (United States)

    Kazemzadeh, Abe

    2013-01-01

    This dissertation studies how people describe emotions with language and how computers can simulate this descriptive behavior. Although many non-human animals can express their current emotions as social signals, only humans can communicate about emotions symbolically. This symbolic communication of emotion allows us to talk about emotions that we…

  1. Use cases versus task descriptions

    DEFF Research Database (Denmark)

    Lauesen, Søren; Kuhail, Mohammad Amin

    2011-01-01

    to specify require-ments for the same project: Acquire a new system to support a hotline. [Princi-pal ideas/results] Among the 15 replies, eight used traditional use cases that specified a dialog between users and system. Seven used a related technique, task description, which specified the customer's needs...

  2. Geotechnical Description of Mineral Deposits

    Directory of Open Access Journals (Sweden)

    Sasvári Tibor

    1996-06-01

    Full Text Available Performing various mineral deposits extraction methods requires thorough knowledge of the rock masses` geomechanical parameters. In the geotechnical description of mineral deposits there is proposed a methodical approarch at the collection, registration, and evaluation of rock masses` geological properties for geotechnics being applied within the mining industry.

  3. Epsilon. A System Description Language

    DEFF Research Database (Denmark)

    Jensen, Kurt; Kyng, Morten

    This paper discusses the use of Petri nets as a semantic tool in the design of languages and in the construction and analysis of system descriptions. The topics treated are: -- Languages based on nets. -- The problem of time in nets. -- Nets and related models. -- Nets and formal semantics. -- Pa...

  4. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of 1-Bromopropane (1-BP).

    Science.gov (United States)

    2003-10-01

    The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for 1-bromopropane to cause adverse effects on reproduction and development in humans. 1-Bromopropane was selected for evaluation due to recent consideration of 1-bromopropane as a replacement chemical for hydrochlorofluorocarbons and chlorinated solvents. 1-Bromopropane is used in spray adhesives and in cleaning metal and electronic components; as a solvent for fats, waxes, or resins; and as an intermediate in the synthesis of pharmaceuticals, insecticides, quaternary ammonium compounds, flavors, or fragrances. The results of this evaluation on 1-brompropane are published in a NTP-CERHR monograph which includes: 1) the NTP Brief, 2) the Expert Panel Report on the Reproductive and Developmental Toxicity of 1-Bromopropane, and 3) public comments received on the Expert Panel Report. As stated in the NTP Brief, the NTP reached the following conclusions regarding the possible effects of exposure to 1-bromopropane on human development and reproduction. No data were available on 1-bromopropane exposures in the general US population. Therefore, conclusions were based on the available occupational exposure data and on studies in humans and laboratory animals. First, there is serious concern for reproductive and developmental effects at the upper end of the human occupational exposure range (18-381 ppm). Adverse developmental and/or reproductive effects have been reported in animal studies at exposure levels of >/=200 ppm. Second, there is minimal concern for reproductive and developmental effects when humans are exposed at the lower end of the human occupational exposure range (0.04-0.63 ppm). This level is at least 300- fold lower than the no effect level identified from reproductive studies in laboratory animals. These conclusions are based upon limited occupational inhalation exposure data. It is likely that worker exposures

  5. Towards a Mathematical Description of Biodiversity Evolution

    Directory of Open Access Journals (Sweden)

    Jorge E. Horvath

    2014-09-01

    Full Text Available We outline in this work a mathematical description of biodiversity evolution based on a second-order differential equation (also known as the “inertial/Galilean view”. After discussing the motivations and explicit forms of the simplest “forces”, we are lead to an equation analogue to a harmonic oscillator. The known solutions for the homogeneous problem are then tentatively related to the biodiversity curves of Sepkoski and Alroy et al., suggesting mostly an inertial behavior of the time evolution of the number of genera and a quadratic behavior in some long-term evolution after extinction events. We present the Green function for the dynamical system and apply it to the description of the recovery curve after the Permo-Triassic extinction, as recently analyzed by Burgess, Bowring and Shen. Even though the agreement is not satisfactory, we point out direct connections between observed drop times after massive extinctions and mathematical constants and discuss why the failure ensues, suggesting a more complex form of the second-order mathematical description.

  6. A Descriptive Genetic Classification for Glaciovolcanoes

    Science.gov (United States)

    Edwards, B. R.; Russell, K.; Porritt, L. A.

    2014-12-01

    We review the recently published descriptive genetic classification for glaciovolcanoes (Russell et al., Quat Sci Rv, 2014). The new classification uses 'tuya' as a root word for all glaciovolcanic edifices, and with modifiers that make the classification descriptive (e.g., andesitic, lava-dominated, flat topped tuya). Although tuyas can range in composition from basaltic to rhyolitic, many of the characteristics diagnostic of glaciovolcanic environments are largely independent of lava composition (e.g., edifice morphology, columnar jointing patterns, glass distributions, pyroclast shapes). Tuya subtypes are first classified on the basis of variations in edifice-scale morphologies (e.g., conical tuya) then, on the proportions of the essential lithofacies (e.g., tephra-dominated conical tuya), and lastly on magma composition (e.g., basaltic, tephra-dominated, conical tuya). The lithofacies associations within tuyas broadly record the interplay between magmatic and glaciohydraulic conditions extent during the active phases of the eruption, including the dominant style of eruption (e.g., explosive vs. effusive). We present nine distinct, endmember models for glaciovolcanic edifices that simultaneously record changes in eruption conditions (explosive, transitional, effusive) for different general glaciohydraulic conditions (closed/sealed, leaky/partly sealed, open/well-drained). To date we have identified potential examples for 7 of the 9 models. Use of a simplified, descriptive classification scheme for glaciovolcanoes will facilitate communications amongst volcanologists and planetary scientists and the use of tuyas for recovering critical paleo-environmental information, particularly the local glaciohydraulics extent during eruptions.

  7. Towards a Mathematical Description of Biodiversity Evolution

    Science.gov (United States)

    Horvath, Jorge E.

    2014-09-01

    We outline in this work a mathematical description of biodiversity evolution based on a second-order differential equation (also known as the "inertial/Galilean view"). After discussing the motivations and explicit forms of the simplest "forces", we are lead to an equation analogue to a harmonic oscillator. The known solutions for the homogeneous problem are then tentatively related to the biodiversity curves of Sepkoski and Alroy et al., suggesting mostly an inertial behavior of the time evolution of the number of genera and a quadratic behavior in some long-term evolution after extinction events. We present the Green function for the dynamical system and apply it to the description of the recovery curve after the Permo-Triassic extinction, as recently analyzed by Burgess, Bowring and Shen. Even though the agreement is not satisfactory, we point out direct connections between observed drop times after massive extinctions and mathematical constants and discuss why the failure ensues, suggesting a more complex form of the second-order mathematical description.

  8. LiveDescribe: Can Amateur Describers Create High-Quality Audio Description?

    Science.gov (United States)

    Branje, Carmen J.; Fels, Deborah I.

    2012-01-01

    Introduction: The study presented here evaluated the usability of the audio description software LiveDescribe and explored the acceptance rates of audio description created by amateur describers who used LiveDescribe to facilitate the creation of their descriptions. Methods: Twelve amateur describers with little or no previous experience with…

  9. 29 CFR 2520.102-2 - Style and format of summary plan description.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Style and format of summary plan description. 2520.102-2... Descriptions § 2520.102-2 Style and format of summary plan description. (a) Method of presentation. The summary... than the style, captions, printing type, and prominence used to describe or summarize plan...

  10. Domain Endurants: An Analysis and Description Process Model

    DEFF Research Database (Denmark)

    Bjørner, Dines

    2014-01-01

    We present a summary, Sect. 2, of a structure of domain analysis and description concepts: techniques and tools. And we link, in Sect. 3, these concepts, embodied in domain analysis prompts and domain description prompts, in a model of how a diligent domain analyser cum describer would use them. ...... claim that both sections, Sects. 2–3, contribute to a methodology of software engineering.......We present a summary, Sect. 2, of a structure of domain analysis and description concepts: techniques and tools. And we link, in Sect. 3, these concepts, embodied in domain analysis prompts and domain description prompts, in a model of how a diligent domain analyser cum describer would use them. We...

  11. Presentation on Instructional Objectives

    Science.gov (United States)

    Naz, Bibi Asia

    2009-01-01

    "Learning can be defined as change in a student's capacity for performance as a result of experience" (Kenneth D. Moore). The intended changes should be specified in instructional objectives. Viewed in this context, an objective can be defined as a clear and unambiguous description of your instructional intent. An objective is not a…

  12. Design and Implementation of Test Flow Description Language

    Institute of Scientific and Technical Information of China (English)

    MENG Chen; WANG Cheng; YANG Suo-chang

    2009-01-01

    A test flow description language is designed for the description of test flow. The design concept, composition, program structure and syntax structure of statement are presented. The development and impletementation processes of the language are also described. This language is independent of hardware, which can be used for different platforms, and can be extended. The language is used to describe the test flow easily. It simplifies the development process of test software and reduces the difficulty of software maintenance greatly.

  13. Shāh-nāme Stories: from Independence to Solidarity (A Survey and Critique of Mythological and Historicist Views on the Narrative Structure Analysis of Shāh-nāme: Presenting a New Paradigm of Structure through Descriptive Criticism

    Directory of Open Access Journals (Sweden)

    فرزاد قائمی

    2012-05-01

    Full Text Available The stories of Ferdowsi’s, Shāh-nāme, despite seeming independence, create, in a coherent form, an organic whole. This narrative complexity has caused scholars for a long time, to attempt to discover links that connect the stories. There have been three viewpoints regarding the analysis of mythical or historical features of Shāh-nāme kings, and the interpretation of the longitudinal axis of its narratives: the triple division of Bertels and his followers, as Safa and Starikov; the historicist interpretation of critics such as Arthur Christensen, Mary Boyce, W. B. Henning and Khāleghi-e Motlagh, concerning the historical connections between stories; and the mythological interpretation of mythologists, such as Dümézil, Wikander, Mayrhofer, Sarkārāti and Mokhtāri, known to have based the solidarity of the longitudinal axis of the text on its systematic mythological deep-structure. This paper, after the examination and Critique of these theories, has attempted to give a new reading of raison d’être of the narrative solidarity of Shāh-nāme, based on descriptive criticism, and finally, divide the longitudinal axis of the stories into three major paradigms: The First being "The Mythical History" or "The Symbolic History of The Race of Man, and of Iran" (from Kayumarth to Keikhosrow; the Second being:"The History of the rise of Religion" or "the Religious History" (from Lohrāsp to Kayānid Bahman; and the Third: "the Narrative History" (from Achaemenid Bahman to the end. The aforementioned triple paradigm is a recurrent model, compatible with the cyclic nature of mythological continuity of time. Accordingly, it is possible to perceive the structural manifestations of these patterned models in Shāh-nāme’s narrative structure.

  14. The Athena Data Dictionary and Description Language

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    We have developed a data object description tool suite and service for Athena consisting of :a language grammar based upon an extended proper subset of IDL 2.0,a compiler front end based upon this language grammar,JavaCC,and a Java Reflection API-like interface,and several compiler back ends which meet specific needs in ATLAS such as automatic generation of object converters and data object scripting interfaces.We present here details of our work and experience to date on the Athena Definition Language and Athena Data Dictionary.

  15. Description of the TRT Readout Scheme

    CERN Document Server

    Luehring, F C

    2002-01-01

    This paper documents the TRT detector readout scheme. A description is provided of the data buffers used in the TRT readout chain: the single TRT channel output data format, the DTMROC output data buffer format, the TRT-ROD input FIFO data format, the TRT-ROD output buffer format, and the ROB output buffer data format. Also documented are the current designs for the TRT-ROD zero suppression and data compression schemes. A proposal is presented for ordering the data generated by individual TRT channels suitably for Level-2 triggering, Level-3 triggering and offline data processing.

  16. Clinical roundtable monograph: Recent advances in the treatment of mantle cell lymphoma: a post-ASH 2009 discussion.

    Science.gov (United States)

    Czuczman, Myron S; Leonard, John P; Williams, Michael E

    2010-04-01

    Mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkin lymphoma characterized by CD5 expression and a t(11;14) cytogenetic translocation that results in overexpression of the cyclin D1 gene. Currently, there is no standard of care for the treatment of MCL, and patient prognosis is poor. Traditional treatments for MCL rely on conventional chemotherapy agents, including cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). The addition of the immunotherapeutic agent rituximab to this regimen (CHOP-R) has helped to improve patient response to treatment. These treatments often provide good initial responses that are difficult to sustain. Therefore, a number of newer agents and combinations have been investigated to produce more durable benefit. Several of these advances were reported at the 51st American Society of Hematology (ASH) Annual Meeting and Exposition, held December 5-8, 2009 in New Orleans, Louisiana. In this clinical roundtable monograph, new strategies in the treatment of MCL are discussed. Some of the drug classes examined here are proteasome inhibitors, inhibitors of the protein mammalian target of rapamycin (mTOR), the unique alkylating agent bendamustine, and immunomodulatory agents.

  17. 60 YEARS OF NEUROENDOCRINOLOGY: Celebrating the brain's other output-input system and the monograph that defined neuroendocrinology.

    Science.gov (United States)

    Coen, Clive W

    2015-08-01

    The brain's unimaginably complex operations are expressed in just two types of output: muscle activity and hormone release. These are the means by which the brain acts beyond its bony casing. Muscle-mediated actions (such as speaking, writing, pupillary reflexes) send signals to the outside world that may convey thoughts, emotions or evidence of neurological disorder. The outputs of the brain as a hormone secreting gland are usually less evident. Their discovery required several paradigm shifts in our understanding of anatomy. The first occurred in 1655. Exactly 300 years later, Geoffrey Harris' monograph Neural control of the pituitary gland launched the scientific discipline that is now known as neuroendocrinology. His hypotheses have stood the test of time to a remarkable degree. A key part of his vision concerned the two-way 'interplay between the central nervous system and endocrine glands'. Over the past 60 years, the importance of this reciprocity and the degree to which cerebral functions are influenced by the endocrine environment have become increasingly clear. © 2015 Society for Endocrinology.

  18. DEVELOPMENT OF METHOD OF QUALITATIVE ANALYSIS OF BIRD CHERRY FRUIT FOR INCLUSION IN THE MONOGRAPH OF STATE PHARMACOPOEIA OF UKRAINE

    Directory of Open Access Journals (Sweden)

    Lenchyk L.V.

    2016-06-01

    Full Text Available Introduction. Bird cherry Padus avium Mill, Rosaceae, is widespread in Ukraine, especially in forests and forest-steppe areas. Bird cherry fruits have long been used in medicine and is a valuable medicinal raw materials. They stated to posess astringent, anti-inflammatory, phytoncidal properties. Bird cherry fruits are included in the USSR Pharmacopoeia IX ed., The State Pharmacopoeia of the Russian Federation, The State Pharmacopoeia of Republic of Belarus. In Ukraine there are no contemporary normative documents for this medicinal plant material, therefore it is the actual to develop projects in the national monographs "dry bird cherry fruit" and "fresh bird cherry fruit" to be included in the State Pharmacopoeia of Ukraine. According to European Pharmacopoeia recommendation method of thin-layer chromatography (TLC is prescribed only for the identification of the herbal drug. The principles of thin-layer chromatography and application of the technique in pharmaceutical analysis are described in State Pharmacopoeia of Ukraine. As it is effective and easy to perform, and the equipment required is inexpensive, the technique is frequently used for evaluating medicinal plant materials and their preparations. The TLC is aimed at elucidating the chromatogram of the drug with respect to selected reference compounds that are described for inclusion as reagents. Aim of this study was to develop methods of qualitative analysis of bird cherry fruits for a monograph in the State Pharmacopoeia of Ukraine (SPU. Materials and Methods. The object of our study was dried bird cherry fruits (7 samples and fresh bird cherry fruits (7 samples harvested in 2013-2015 in Kharkiv, Poltava, Luhansk, Sumy, Lviv, Mykolaiv regions and the city Mariupol. Samples were registered in the department of SPU State Enterprise "Pharmacopeia center". In accordance with the Ph. Eur. and SPU requirements in "identification C" determination was performed by TLC. TLC was performed on

  19. Abstract Presentations: What Do SGIM Presenters Prefer?

    OpenAIRE

    Tulsky, Asher A.; Kouides, Ruth W

    1998-01-01

    We surveyed physicians presenting abstracts at the 1995 Society of General Internal Medicine annual meeting to determine whether the oral or poster format better achieved their presentation goals. Poster presentations better met respondents' objectives for feedback and criticism and for networking and developing collaborative projects, while oral presentations better met their objectives for national visibility and sharing knowledge within one's field. Sixty-nine percent of respondents prefer...

  20. Formative value of descriptive grades in mathematics instruction for beginners

    Directory of Open Access Journals (Sweden)

    Đelić Jasmina

    2016-01-01

    Full Text Available Descriptive grading has been implemented in the first grade of primary school in the Republic of Serbia from 2003. The monitoring of this system novelty has been absent since research community most often dealt with teachers’ attitudes and their self-evaluation of the competences for descriptive grading. This form of grading, which stems from the social constructivist paradigm, is observed as the trigger of development of the formative approach in assessment, which has been in the focus of theoreticians and practitioners in the past thirty years, especially in the United States of America and Great Britain. The method of content analysis was applied to 316 descriptive grades in mathematics given to first grade primary students. The quality of three key elements was assessed: the description of academic achievement, the description of students’ engagement and the recommendations to achieve further progress, as well as the balance of quality between the elements of the same descriptive grade. Research results have shown that descriptive grades mostly lack the necessary formative capacity. This means that the majority of students this sample of grades was prepared for did not receive quality and comprehensive feedback, which would be conducive for their further education. Formative assessment, as one of the implications of the constructivist theoretical grounding, demands a high level of development of teacher competences for monitoring the progress and assessing the students, which has not been confirmed in the present research.

  1. Chessboard-interpolation-based multiple description video coding

    Institute of Scientific and Technical Information of China (English)

    FAN Chen; CUI Huijuan; TANG Kun

    2004-01-01

    To enhance the robustness of video transmission over noisy channels, this paper presents a multiple description video coding algorithm based on chessboardinterpolation. In the algorithm, the input image is decomposed according to the chessboard pattern, and then interpolated to produce two approximate images with the same resolution. Consequently, the state-of-the-art DCT+MC (Discrete Cosine Transform + Motion Compensation) video codec is independently applied to the two approximate images to generate two descriptions of the original image. In this framework, a fairely good reconstructed image quality is obtained when two descriptions are received simultaneously, while an acceptable reconstructed image quality could be yielded if only one description is available. Moreover, the mismatch between the encoder and the decoder could be effectively controlled through partial coding of the difference signal between two descriptions. In bidirectional video communications, a drift control scheme is further proposed, in which the error drift could be eliminated after the encoder imitating the error concealment actions of the decoder. Since the inherent correlation among adjacent blocks of DCT+MC video coding is efficiently exploited, this algorithm has a better redundancy-rate-distortion (RRD) performance than other multiple description algorithms. Simulation results show that the proposed algorithm is fairly robust while preserves a high compression rate. A more constant reconstructed image quality is achieved over extremely noisy channels, compared with traditional single description coding. In addition, it is observed that the mismatch and the error drift are effectively controlled.

  2. African swine fever: background, present time and prospects

    Science.gov (United States)

    The purpose of this monograph is to summarize the existing international and national experience of monitoring, diagnostics, forecasting, and implementing measures of management and control of ASF. This publication contains national and international regulatory documents, reference materials and the...

  3. GROUNDWATER PROTECTION MANAGEMENT PROGRAM DESCRIPTION.

    Energy Technology Data Exchange (ETDEWEB)

    PAQUETTE,D.E.; BENNETT,D.B.; DORSCH,W.R.; GOODE,G.A.; LEE,R.J.; KLAUS,K.; HOWE,R.F.; GEIGER,K.

    2002-05-31

    THE DEPARTMENT OF ENERGY ORDER 5400.1, GENERAL ENVIRONMENTAL PROTECTION PROGRAM, REQUIRES THE DEVELOPMENT AND IMPLEMENTATION OF A GROUNDWATER PROTECTION PROGRAM. THE BNL GROUNDWATER PROTECTION MANAGEMENT PROGRAM DESCRIPTION PROVIDES AN OVERVIEW OF HOW THE LABORATORY ENSURES THAT PLANS FOR GROUNDWATER PROTECTION, MONITORING, AND RESTORATION ARE FULLY DEFINED, INTEGRATED, AND MANAGED IN A COST EFFECTIVE MANNER THAT IS CONSISTENT WITH FEDERAL, STATE, AND LOCAL REGULATIONS.

  4. Personality: Description, Classification and Evaluation

    OpenAIRE

    Ibrahim Taymur; M. Hakan TURKCAPAR

    2012-01-01

    Many descriptions and classifications of personality have been made to understand and acknowledge human being through out the history. During the developmental process of psychiatry, almost every school defined and assessed personality regarding to their own perspective. As DSM (Diagnostical and Statistical Manual of Mental Disorders) and ICD (International Classification of Diseases) being available to common usage, scientists conducted studies to set a common terminology for personality. Ca...

  5. Personality: Description, Classification and Evaluation

    Directory of Open Access Journals (Sweden)

    Ibrahim Taymur

    2012-06-01

    Full Text Available Many descriptions and classifications of personality have been made to understand and acknowledge human being through out the history. During the developmental process of psychiatry, almost every school defined and assessed personality regarding to their own perspective. As DSM (Diagnostical and Statistical Manual of Mental Disorders and ICD (International Classification of Diseases being available to common usage, scientists conducted studies to set a common terminology for personality. Categorical and dimensional approaches are the most fundamentally different assessment strategies in the research and clinical aspects about personality. While categorical approach views the personality as dichotomies which consists of different groups, dimensional approach aims to describe the personality on the basis of dimensions, thus suggests that the personality is a structure formed by definite dimensions. Several advantages and disadvantages can be noticed when descriptions of personality and tools for the evaluation of personality are reviewed. When the section making suggestions about personality disorder in DSM-5 is evaluated, it is seen that it aims to restructure the personality disorder diagnostic group according to new findings and critiques. In this article, the description of personality throughout the history, dimensional, categorical and cognitive approaches to personality, the features of the tools that are used to assess and measure the personality are reviewed.

  6. Geometric description of images as topographic maps

    CERN Document Server

    Caselles, Vicent

    2010-01-01

    This volume discusses the basic geometric contents of an image and presents a tree data structure to handle those contents efficiently. The nodes of the tree are derived from connected components of level sets of the intensity, while the edges represent inclusion information. Grain filters, morphological operators simplifying these geometric contents, are analyzed and several applications to image comparison and registration, and to edge and corner detection, are presented. The mathematically inclined reader may be most interested in Chapters 2 to 6, which generalize the topological Morse description to continuous or semicontinuous functions, while mathematical morphologists may more closely consider grain filters in Chapter 3. Computer scientists will find algorithmic considerations in Chapters 6 and 7, the full justification of which may be found in Chapters 2 and 4 respectively. Lastly, all readers can learn more about the motivation for this work in the image processing applications presented in Chapter 8...

  7. Psychosocial Rehabilitation and Mental Illness: Views from Africa, India, Asia and Australia. Monograph Series, Number 49.

    Science.gov (United States)

    Anthony, William A., Ed.; Wolkon, George H., Ed.

    1990-01-01

    This special journal "Theme" issue presents a collection of papers reflecting the psychiatric practices and community treatment for persons with severe psychiatric disabilities in Asia, Africa, Australia, and India. Some of the papers were presented at the 1988 meeting of the World Association of Psychosocial Rehabilitation (WAPR) in…

  8. Simpevarp - site descriptive model version 0

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-11-01

    During 2002, SKB is starting detailed investigations at two potential sites for a deep repository in the Precambrian rocks of the Fennoscandian Shield. The present report concerns one of those sites, Simpevarp, which lies in the municipality of Oskarshamn, on the southeast coast of Sweden, about 250 kilometres south of Stockholm. The site description will have two main components: a written synthesis of the site, summarising the current state of knowledge, as documented in the databases containing the primary data from the site investigations, and one or several site descriptive models, in which the collected information is interpreted and presented in a form which can be used in numerical models for rock engineering, environmental impact and long-term safety assessments. SKB maintains two main databases at the present time, a site characterisation database called SICADA and a geographic information system called SKB GIS. The site descriptive model will be developed and presented with the aid of the SKB GIS capabilities, and with SKBs Rock Visualisation System (RVS), which is also linked to SICADA. The version 0 model forms an important framework for subsequent model versions, which are developed successively, as new information from the site investigations becomes available. Version 0 is developed out of the information available at the start of the site investigation. In the case of Simpevarp, this is essentially the information which was compiled for the Oskarshamn feasibility study, which led to the choice of that area as a favourable object for further study, together with information collected since its completion. This information, with the exception of the extensive data base from the nearby Aespoe Hard Rock Laboratory, is mainly 2D in nature (surface data), and is general and regional, rather than site-specific, in content. Against this background, the present report consists of the following components: an overview of the present content of the databases

  9. Presentation rubric: improving faculty professional presentations.

    Science.gov (United States)

    Hayne, Arlene N; McDaniel, Gretchen S

    2013-01-01

    This article describes the content of a presentation evaluation rubric for use in the development and improvement in faculty performance to enhance learning. Lectures or professional presentations require skills that can be learned through the use of evidence-based practices for all forms of public speaking. A core competency of nursing faculty is to serve as a role model in skilled oral communication. The use of an evaluation presentation rubric can increase faculty competency in this area. © 2013 Wiley Periodicals, Inc.

  10. Transport properties site descriptive model. Guidelines for evaluation and modelling

    Energy Technology Data Exchange (ETDEWEB)

    Berglund, Sten [WSP Environmental, Stockholm (Sweden); Selroos, Jan-Olof [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)

    2004-04-01

    This report describes a strategy for the development of Transport Properties Site Descriptive Models within the SKB Site Investigation programme. Similar reports have been produced for the other disciplines in the site descriptive modelling (Geology, Hydrogeology, Hydrogeochemistry, Rock mechanics, Thermal properties, and Surface ecosystems). These reports are intended to guide the site descriptive modelling, but also to provide the authorities with an overview of modelling work that will be performed. The site descriptive modelling of transport properties is presented in this report and in the associated 'Strategy for the use of laboratory methods in the site investigations programme for the transport properties of the rock', which describes laboratory measurements and data evaluations. Specifically, the objectives of the present report are to: Present a description that gives an overview of the strategy for developing Site Descriptive Models, and which sets the transport modelling into this general context. Provide a structure for developing Transport Properties Site Descriptive Models that facilitates efficient modelling and comparisons between different sites. Provide guidelines on specific modelling issues where methodological consistency is judged to be of special importance, or where there is no general consensus on the modelling approach. The objectives of the site descriptive modelling process and the resulting Transport Properties Site Descriptive Models are to: Provide transport parameters for Safety Assessment. Describe the geoscientific basis for the transport model, including the qualitative and quantitative data that are of importance for the assessment of uncertainties and confidence in the transport description, and for the understanding of the processes at the sites. Provide transport parameters for use within other discipline-specific programmes. Contribute to the integrated evaluation of the investigated sites. The site descriptive

  11. Production Logistics Simulation Supported by Process Description Languages

    Directory of Open Access Journals (Sweden)

    Bohács Gábor

    2016-03-01

    Full Text Available The process description languages are used in the business may be useful in the optimization of logistics processes too. The process description languages would be the obvious solution for process control, to handle the main sources of faults and to give a correct list of what to do during the logistics process. Related to this, firstly, the paper presents the main features of the frequent process description languages. The following section describes the currently most used process modelling languages, in the areas of production and construction logistics. In addition, the paper gives some examples of logistics simulation, as another very important field of logistics system modelling. The main edification of the paper, the logistics simulation supported by process description languages. The paper gives a comparison of a Petri net formal representation and a Simul8 model, through a construction logistics model, as the major contribution of the research.

  12. The Role of XML in the CMS Detector Description

    Institute of Scientific and Technical Information of China (English)

    M.Liendl; F.vanLingen; 等

    2001-01-01

    Offline Software such as Simulation,Reconstruction,Analysis,and Visualisation are all in need of a detector description.These applications have several common but also many specific requirements for the detector description in order to build up their internal representations.To achieve this in a consistent and coherent manner a common source of information,the detector description database,will be consulted by each of the applications.The role and suitability of XML in the design of the detector description database in the scope of the CMS detector at the LHC is discussed.Different aspects such as data modelling capabilities of XML,tool support,integration to C++ representations of data models are treated and recent results of prototype implementations are presented.

  13. Forsmark - site descriptive model version 0

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-10-01

    During 2002, the Swedish Nuclear Fuel and Waste Management Company (SKB) is starting investigations at two potential sites for a deep repository in the Precambrian basement of the Fennoscandian Shield. The present report concerns one of those sites, Forsmark, which lies in the municipality of Oesthammar, on the east coast of Sweden, about 150 kilometres north of Stockholm. The site description should present all collected data and interpreted parameters of importance for the overall scientific understanding of the site, for the technical design and environmental impact assessment of the deep repository, and for the assessment of long-term safety. The site description will have two main components: a written synthesis of the site, summarising the current state of knowledge, as documented in the databases containing the primary data from the site investigations, and one or several site descriptive models, in which the collected information is interpreted and presented in a form which can be used in numerical models for rock engineering, environmental impact and long-term safety assessments. The site descriptive models are devised and stepwise updated as the site investigations proceed. The point of departure for this process is the regional site descriptive model, version 0, which is the subject of the present report. Version 0 is developed out of the information available at the start of the site investigation. This information, with the exception of data from tunnels and drill holes at the sites of the Forsmark nuclear reactors and the underground low-middle active radioactive waste storage facility, SFR, is mainly 2D in nature (surface data), and is general and regional, rather than site-specific, in content. For this reason, the Forsmark site descriptive model, version 0, as detailed in the present report, has been developed at a regional scale. It covers a rectangular area, 15 km in a southwest-northeast and 11 km in a northwest-southeast direction, around the

  14. Facilitating Description and Selection of Learning Paths: the learning path specification put to the test

    NARCIS (Netherlands)

    Janssen, José

    2008-01-01

    Jansen, J. (2008). Facilitating Description and Selection of Learning Paths: the learning path specification put to the test. Presentation at the Otec Colloquium. April, 2008, Heerlen, The Netherlands.

  15. Facilitating Description and Selection of Learning Paths: the learning path specification put to the test

    NARCIS (Netherlands)

    Janssen, José

    2008-01-01

    Jansen, J. (2008). Facilitating Description and Selection of Learning Paths: the learning path specification put to the test. Presentation at the Otec Colloquium. April, 2008, Heerlen, The Netherlands.

  16. Making your presentation fun: creative presentation techniques

    Energy Technology Data Exchange (ETDEWEB)

    KEENEN,MARTHA JANE

    2000-05-18

    What possesses someone to volunteer and go through hoops and red tape to make a presentation at a conference? For that matter, why does anyone ever present anything to anyone? Actually, presentations are a fact of life and there are many reasons for doing a presentation and doing it well. New and existing staff need training and orientation to the way things are done here. Handing all of them a manual and hoping they read it is pretty much a waste of paper. On the other hand, an effective, entertaining and upbeat presentation on the relevant topics is more likely to stick with those people. They will even have a name and face to remember and seek out when they have an issue on or with that topic. This can be a very effective beginning for networking with new peers. The presenter is seen as knowledgeable, as a source of information on company topics and possibly evaluated as a potential mentor or future manager. Project staff and/or peers benefit from clear, concise, presentations of topical knowledge. This is one way that a group working on various aspects of the same project or program can stay in touch and in step with each other. Most importantly, presentations may be the best or only door into the minds (and budgets) of management and customers. These presentations are a wonderful opportunity to address legal and compliance issues, budget, staffing, and services. Here is a chance, maybe the only one, to demonstrate and explain the wonderfulness of a program and the benefit they get by using the services offered most effectively. An interactive presentation on legal and compliance issues can be an effective tool in helping customers and/or management make good risk management decisions.

  17. Stereo Orthogonal Axonometric Perspective for the Teaching of Descriptive Geometry

    Science.gov (United States)

    Méxas, José Geraldo Franco; Guedes, Karla Bastos; Tavares, Ronaldo da Silva

    2015-01-01

    Purpose: The purpose of this paper is to present the development of a software for stereo visualization of geometric solids, applied to the teaching/learning of Descriptive Geometry. Design/methodology/approach: The paper presents the traditional method commonly used in computer graphic stereoscopic vision (implemented in C language) and the…

  18. Stereo Orthogonal Axonometric Perspective for the Teaching of Descriptive Geometry

    Science.gov (United States)

    Méxas, José Geraldo Franco; Guedes, Karla Bastos; Tavares, Ronaldo da Silva

    2015-01-01

    Purpose: The purpose of this paper is to present the development of a software for stereo visualization of geometric solids, applied to the teaching/learning of Descriptive Geometry. Design/methodology/approach: The paper presents the traditional method commonly used in computer graphic stereoscopic vision (implemented in C language) and the…

  19. ELECTRICAL SUPPORT SYSTEM DESCRIPTION DOCUMENT

    Energy Technology Data Exchange (ETDEWEB)

    S. Roy

    2004-06-24

    The purpose of this revision of the System Design Description (SDD) is to establish requirements that drive the design of the electrical support system and their bases to allow the design effort to proceed to License Application. This SDD is a living document that will be revised at strategic points as the design matures over time. This SDD identifies the requirements and describes the system design as they exist at this time, with emphasis on those attributes of the design provided to meet the requirements. This SDD has been developed to be an engineering tool for design control. Accordingly, the primary audience/users are design engineers. This type of SDD both ''leads'' and ''trails'' the design process. It leads the design process with regard to the flow down of upper tier requirements onto the system. Knowledge of these requirements is essential in performing the design process. The SDD trails the design with regard to the description of the system. The description provided in the SDD is a reflection of the results of the design process to date. Functional and operational requirements applicable to electrical support systems are obtained from the ''Project Functional and Operational Requirements'' (F&OR) (Siddoway 2003). Other requirements to support the design process have been taken from higher-level requirements documents such as the ''Project Design Criteria Document'' (PDC) (Doraswamy 2004), and fire hazards analyses. The above-mentioned low-level documents address ''Project Requirements Document'' (PRD) (Canon and Leitner 2003) requirements. This SDD contains several appendices that include supporting information. Appendix B lists key system charts, diagrams, drawings, and lists, and Appendix C includes a list of system procedures.

  20. Task descriptions versus use cases

    DEFF Research Database (Denmark)

    Lauesen, Søren; Kuhail, Mohammad Amin

    2011-01-01

    Use cases are widely used as a substantial part of requirements, also when little programming is expected (COTS-based systems, Commercial-Off-The-Shelf). Are use cases effective as requirements? To answer this question, we invited professionals and researchers to specify requirements for the same...... project: Acquire a new system to support a hotline. Among the 15 replies, eight used traditional use cases that specified a dialog between user and system. Seven used a related technique, task description, which specified the customer’s needs without specifying a dialog. It also allowed the analyst...

  1. Use cases versus task descriptions

    DEFF Research Database (Denmark)

    Lauesen, Søren; Kuhail, Mohammad Amin

    2011-01-01

    Abstract. [Context and motivation] Use cases are widely used as a substantial part of requirements, also when little programming is expected (COTS-based systems). [Question/problem] Are use cases effective as requirements? To an-swer this question, we invited professionals and researchers...... to specify require-ments for the same project: Acquire a new system to support a hotline. [Princi-pal ideas/results] Among the 15 replies, eight used traditional use cases that specified a dialog between users and system. Seven used a related technique, task description, which specified the customer's needs...

  2. Inflationary universe in fluid description

    CERN Document Server

    Bamba, Kazuharu

    2016-01-01

    We investigate a fluid description of inflationary cosmology. It is shown that the three observables of the inflationary universe: the spectral index of the curvature perturbations, the tensor-to-scalar ratio of the density perturbations, and the running of the spectral index, can be compatible with the Planck analysis. In addition, we reconstruct the equation of state (EoS) for a fluid from the spectral index of the curvature perturbations consistent with the Planck results. We explicitly demonstrate that the universe can gracefully exit from inflation in the reconstructed fluid models. Furthermore, we explore the singular inflation for a fluid model.

  3. College Readiness -- A Simple Description

    Directory of Open Access Journals (Sweden)

    Jerome Dancis

    2012-01-01

    Full Text Available To survive academically the first year of college, students basically need the three Rs, Reading, wRiting and aRithmetic, albeit all on high school levels. No Statistics needed.Reading means reading with understanding the expository and descriptive text in science and social studies textbooks, not literature. This includes following written directions. Writing means writing a coherent summary of each chapter in the science and social studies textbooks, and relating the chapter to material previously studied. Arithmetic means Arithmetic, including fractions, decimals, percents, measurement and multi-step Arithmetic word problems, along with “generalized” Arithmetic, better known as Algebra.

  4. IUE/IRA system description

    Science.gov (United States)

    Jennings, J.

    1977-01-01

    The IUE/IRA rate sensor system designed to meet the requirements of the International Ultraviolet Explorer spacecraft mission is described. The system consists of the sensor unit containing six rate sensor modules and the electronic control unit containing the rate sensor support electronics and the command/control circuitry. The inertial reference assembly formed by the combined units will provide spacecraft rate information for use in the stabilization and control system. The system is described in terms of functional description, operation redundancy performance, mechanical interface, and electrical interface. Test data obtained from the flight unit are summarized.

  5. Present Situation of Refractories for Baosteel

    Institute of Scientific and Technical Information of China (English)

    TAI Li; SHEN Keyin

    2004-01-01

    The paper reviews the present situation of refractories for Baosteel, including refractories for iron-making system, converters, ladles and tundishes. Descriptions have been also conducted on the environment protection and reutilization of refractories in Baosteel, together with somesuggestions for refractories suppliers to meet the advancement in iron and steel making technology of Baosteel.

  6. Performing Remarkable Feats with Presentation Graphics Packages.

    Science.gov (United States)

    Ekhaml, Leticia

    1994-01-01

    Describes easy-to-use, easy-to-learn dedicated graphics packages for developing slide presentations shown directly from computers. A general description of the features of five packages and suggestions for software selection are provided. A sidebar provides graphics tips, such as the use of color, typefaces, and formatting, for developing…

  7. Conceptual modular description of the high-level waste management system for system studies model development

    Energy Technology Data Exchange (ETDEWEB)

    McKee, R.W.; Young, J.R.; Konzek, G.J.

    1992-08-01

    This document presents modular descriptions of possible alternative components of the federal high-level radioactive waste management system and the procedures for combining these modules to obtain descriptions for alternative configurations of that system. The 20 separate system component modules presented here can be combined to obtain a description of any of the 17 alternative system configurations (i.e., scenarios) that were evaluated in the MRS Systems Studies program (DOE 1989a). First-approximation descriptions of other yet-undefined system configurations could also be developed for system study purposes from this database. The descriptions include, in a modular format, both functional descriptions of the processes in the waste management system, plus physical descriptions of the equipment and facilities necessary for performance of those functions.

  8. Handbook of Manufacturing Control Fundamentals, description, configuration

    CERN Document Server

    Lödding, Hermann

    2013-01-01

    This first-time English publication of one of Germany’s leading manufacturing control handbooks provides a comprehensive overview of the state of the art, with detailed and easy to understand descriptions of numerous control techniques from Kanban to CONWIP to Backlog Control. Based on the proven funnel model and written for the industry, this book clearly illustrates how companies can use manufacturing control to effectively improve on-time delivery, reduce inventories and cut down throughput times. “This book distinguishes itself with its convincing systematic approach based on thorough international research. Its clear presentation and direct applicability for analysing and configuring the manufacturing control make this handbook an outstanding and unique publication on PPC.” Hans-Peter Wiendahl “The field of manufacturing control is very convincingly reviewed and presented from a theoretical and methodological perspective. Both researchers as well as practitioners will profit from it.” Peter N...

  9. Do princípio monográfico à unidade documentária: exploração dos fundamentos da Catalogação | From the monographic principle to the documentary unit: an exploration of the bases of Cataloguing

    Directory of Open Access Journals (Sweden)

    Cristina Dotta Ortega

    2011-03-01

    ípios gerais para a identificação da unidade documentária a partir da qual o registro de informação é construído. Palavras-chave catalogação; representação descritiva; princípio monográfico; unidade documentária; obra; assunto Abstract This article deals with the notion of documentary unit – a minimum informational unit, which is considered to be of interest of a group of users, liable to representation for the constitution of registration of a database – in order to explore the grounds of Cataloguing. Two conceptions have been taken into account: the concept of work proposed by Panizzi as part of the principles for the production of library catalogs, which was later resumed in the Functional Requirements for Bibliographic Records (FRBR model; and the concept of subject as a way to distinguish the intellectual unit (from the physical unit, developed by Documentation and applied in systems of scientific information. It starts from the assumption that these conceptions frame themselves as conceptual-historical approaches to the notion of documentary unit, therefore making  it  belong  to its problematization.  As methodology,  we have carried  out conceptual-historical approaches of the two conceptions mentioned above, and an analyses about their present contribution. First, this article contextualizes Cataloguing, dealing with its aims and with the existing terminology, bearing in mind the processes and tools of production and management of database. Second, it presents some of the principles of Cataloging consolidated by Panizzi in the middle of 19th century, and the monographic principle proposed by Otlet for documentation based on those principles. Then, it discusses those principles and their applications along the 20th century. The article observes that the scenery portraited by these two conceptions, respectively under the predominance of the community of libraries, and the services and nets of scientific information, has taken new contours during

  10. Archival Descriptions from the National Archives Catalog

    Data.gov (United States)

    National Archives and Records Administration — Archival Descriptions from the National Archives Catalog data set provides archival descriptions of the permanent holdings of the federal government in the custody...

  11. Biowaiver monographs for immediate release solid oral dosage forms: metoclopramide hydrochloride.

    Science.gov (United States)

    Stosik, A G; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2008-09-01

    Literature data are reviewed relevant to the decision for a biowaiver of immediate release (IR) solid oral dosage forms containing metoclopramide hydrochloride. In addition, new solubility data, obtained under Biopharmaceutics Classification System (BCS) conditions are presented. Metoclopramide HCl is conservatively assigned to BCS Class III. Taken also into consideration excipient interactions reported in metoclopramide drug products, its pharmacokinetic properties and therapeutic use and therapeutic index, a biowaiver can be recommended when: (a) the test product contains only excipients present also in metoclopramide HCl containing IR solid oral drug products approved in ICH or associated countries, for instance as presented in this paper, (b) in amounts in normal use in IR solid oral dosage forms, and (c) the test product and the comparator both comply with the criteria for very rapidly dissolving.

  12. PREDICTING NORMATIVE AND PROBLEMATIC FAMILY PATHWAYS TO THE TRANSITION TO SIBLINGHOOD: COMMENTARY ON VOLLING ET AL.'S MONOGRAPH.

    Science.gov (United States)

    Howe, Nina

    2017-09-01

    Volling et al.'s monograph provides a rich, thoughtful, and rigorous account of how the transition to siblinghood is experienced by the first-born child and the family. In their comprehensive longitudinal study, they followed 241 families from the prenatal period before the second-born's birth until this child was 12-months old. Siblings are a critical, but understudied, relationship in children's development; the challenges posed in researching sibling dynamics in the context of the family are discussed. Prior psychodynamic and developmental research literature is critiqued, which places the current study into perspective and indicates the important theoretical frameworks (i.e., developmental psychopathology and developmental ecological systems) employed by Volling et al. to advance our understanding of this critical transition in the life of the family. The longitudinal study design, sample characteristics, identification of possible trajectories of adjustment (or not) to the birth of the sibling, and selection of family and child variables are addressed. The sophisticated statistical methods (Growth Mixture Modeling and data mining procedures) employed to predict child adjustment in association with parenting variables over time and sibling relationship quality at 12 months identified low- and high-risk trajectories on the seven subscales of the Child Behavior Check List (CBCL). This afforded a nuanced investigation of a variety of potentially problematic child behaviors (e.g., aggression, withdrawal, negative emotionality, somatic problems) in association with parenting behaviors. A final discussion included study limitations, significant strengths, and implications for clinicians and other professionals. The study's conclusion is that most children and families are resilient, take the birth of a sibling in their stride, and do not exhibit empirical evidence of a developmental crisis, as argued by earlier psychodynamic authors. © 2017 The Society for Research

  13. Pierre Janet's addition to Charles-Hubert-Antoine Despine's "Old but very curious" Estelle L'Hardy monograph.

    Science.gov (United States)

    Brown, Carole Koepke

    2008-01-01

    In the magisterial book The Discovery of the Unconscious, Ellenberger (1970) showed a keen appreciation for practitioners of many schools of therapy, including those who practiced animal magnetism (hypnotism). He credited Despine and Janet for their contributions to dynamic psychiatry and documented Janet's intellectual debt to Despine's successful magnetic treatment of 11-year-old Estelle's hysteria (dissociative disorder). No scholarship, however, has identified Janet's unique addition to Despine's 1838/1839 monograph--written decades before Janet's birth. Supplementing Despine's account of Estelle's minor fall that precipitated her paralysis, Janet reported that Estelle disobeyed her mother by quarreling with a friend, soiled her frock, experienced fright and shame, and sought to conceal everything from her mother. The author argues (a) that Despine knew yet wisely excluded Janet's data lest Estelle's family prevent his publishing the case; (b) that Janet's published data about the youngster's fall reached him through a professional network; and (c) that Janet's plausible addition comports well with his theoretical psychology of action--used in this article to explain the fine-grained parsing of Estelle's inner processes during the milliseconds of her fall: her vehement affect substituted for adaptive behavior. This article deepens the understanding of the Despin-Janet connection; maintains that Janet's addition deserves a place in the tradition of the medical case report; encourages trauma specialists to become familiar with their pioneers; and highlights the clinical continuity from Janet's affirmation of Despine's pioneering treatment strategies with the chronically traumatized to contemporary treatment for the same population, conceptualized along Janetian lines.

  14. Priorities in Dealing with Nutrition Problems in Indonesia. Cornell International Nutrition Monograph Series, Number 1 (1974).

    Science.gov (United States)

    Soekirman

    A study of the literature dealing with past and present food and nutrition problems in Indonesia reveals that the problems remain serious. The major nutrition problems are: (1) Protein-Calorie Malnutrition; (2) Vitamin A Deficiency; (3) Nutritional Anemia; and (4) Goitre. These nutrition problems afflict people of all ages, males and females.…

  15. Patterns of Living in California's Migrant Labor Families. Research Monograph No. 12.

    Science.gov (United States)

    Hawkes, Glenn R.; And Others

    This report presents a study of the living patterns of California's migrant labor families, one part of a national study on the identification of life patterns among relatively disadvantaged families. Data were collected from 169 interviews with homemakers randomly selected from 12 state-owned migrant camps in California. The interviews consisted…

  16. Individual and Distributed Cognitions in Interdisciplinary Teamwork: A Developing Case Study and Emerging Theory. Research Monograph.

    Science.gov (United States)

    Derry, Sharon J.; DuRussel, Lori Adams; O'Donnell, Angela M.

    We present a developing distributed cognition theory of interdisciplinary collaboration that incorporates concepts from both situated cognition and information processing theory. This theoretical framework is being refined as it is used for analyzing interdisciplinary collaboration within the National Institute of Science Education (NISE). The…

  17. A Bibliography of Philippine Language Dictionaries and Vocabularies. Special Monograph Issue, Number 30.

    Science.gov (United States)

    Hendrickson, Gail R., Comp.; Newell, Leonard E., Comp.

    This bibliography is a comprehensive listing of dictionaries and vocabularies, published and unpublished, of the Philippine languages. Introductory sections chronicle briefly the histories of Philippine lexicography and Philippine bibliographies, describe the scope of the present work, and outline the organization of the bibliography itself and…

  18. Collegiate Aviation Research and Education Solutions to Critical Safety Issues. UNO Aviation Monograph Series. UNOAI Report.

    Science.gov (United States)

    Bowen, Brent, Ed.

    This document contains four papers concerning collegiate aviation research and education solutions to critical safety issues. "Panel Proposal Titled Collegiate Aviation Research and Education Solutions to Critical Safety Issues for the Tim Forte Collegiate Aviation Safety Symposium" (Brent Bowen) presents proposals for panels on the…

  19. A Decision Structure for Teaching Machines. M.I.T. PRESS Research Monograph, 14.

    Science.gov (United States)

    Smallwood, Richard D.

    The problem of enabling a teaching machine to adapt to the individual characteristics of students in presenting course material has been considered--general outlines of computer algorithms and decision criteria have been formulated. It is assumed that there exists both an ordered set of concepts which comprise the material to be learned and, for…

  20. Financing Basic Education in Bangladesh. CREATE Pathways to Access. Research Monograph No. 12

    Science.gov (United States)

    Al-Samarrai, Samer

    2007-01-01

    This paper presents education finance trends for Bangladesh since 2000. It shows that while government spending on education as a proportion of national income has stagnated, it has increased in real terms. Real increases in education spending have resulted in substantial increases in per student spending in basic education. At primary, enrolment…

  1. 40 CFR 123.22 - Program description.

    Science.gov (United States)

    2010-07-01

    ... employees. The State need not submit complete job descriptions for every employee carrying out the State... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Program description. 123.22 Section... PROGRAM REQUIREMENTS State Program Submissions § 123.22 Program description. Any State that seeks...

  2. Doença celíaca: a evolução dos conhecimentos desde sua centenária descrição original até os dias atuais Celiac disease: evolution in knowledge since its original centennial description up to the present days

    Directory of Open Access Journals (Sweden)

    Vera Lucia SDEPANIAN

    1999-12-01

    Full Text Available Nos últimos anos, alguns aspectos da doença celíaca têm sido discutidos na literatura, especialmente relacionados à predisposição genética, patogênese, formas de apresentação clínica e critérios diagnósticos. Inúmeros estudos demonstraram anormalidades imunológicas características da doença como a presença de anticorpos circulantes e de linfócitos com receptores gama/delta presentes em grande número a nível intraepitelial da mucosa intestinal. Outras formas de apresentação clínica, além da forma clássica, têm merecido destaque como baixa estatura, anemia resistente à ferroterapia oral, hipoplasia do esmalte dentário, constipação intestinal, manifestações neurológicas e osteoporose, dentre outras. A forma assintomática foi reconhecida especialmente nas duas últimas décadas após o desenvolvimento de marcadores sorológicos como anticorpo antigliadina, anti-reticulina e antiendomísio. Até o presente momento, a biopsia de intestino delgado continua sendo imprescindível para o diagnóstico da doença celíaca. No Brasil, fatos marcantes ocorreram nos últimos anos, como a promulgação da Lei Federal que dispõe sobre a obrigatoriedade dos rótulos dos produtos industrializados informarem sobre a presença de glúten. Houve, também, aumento do número de portadores de doença celíaca cadastrados na Associação dos Celíacos do Brasil.In the recent past, some celiac disease features have been discussed in literature specially related to genetic susceptibility, pathogenesis, clinical presentation and diagnostic criteria. Immunological abnormalities characteristic of celiac disease, such as circulating antibodies and increased numbers of intra-epithelial lymphocytes containing a high percentage of gamma-delta T cells have been demonstrated. Other pictures of clinical presentation besides the classical one deserve attention namely short stature, iron-resistant anaemia, enamel hypoplasia, constipation

  3. Dandruff, seborrheic dermatitis, and psoriasis drug products containing coal tar and menthol for over-the-counter human use; amendment to the monograph. Final rule

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-03-15

    The Food and Drug Administration (FDA) is issuing a final rule amending the final monograph (FM) for over-the-counter (OTC) dandruff, seborrheic dermatitis, and psoriasis drug products to include the combination of 1.8 percent coal tar solution and 1.5 percent menthol in a shampoo drug product to control dandruff. FDA did not receive any comments or data in response to its previously proposed rule to include this combination. This final rule is part of FDA's ongoing review of OTC drug products.

  4. Mathematical description of bacterial traveling pulses.

    Directory of Open Access Journals (Sweden)

    Jonathan Saragosti

    Full Text Available The Keller-Segel system has been widely proposed as a model for bacterial waves driven by chemotactic processes. Current experiments on Escherichia coli have shown the precise structure of traveling pulses. We present here an alternative mathematical description of traveling pulses at the macroscopic scale. This modeling task is complemented with numerical simulations in accordance with the experimental observations. Our model is derived from an accurate kinetic description of the mesoscopic run-and-tumble process performed by bacteria. This can account for recent experimental observations with E. coli. Qualitative agreements include the asymmetry of the pulse and transition in the collective behaviour (clustered motion versus dispersion. In addition, we can capture quantitatively the traveling speed of the pulse as well as its characteristic length. This work opens several experimental and theoretical perspectives since coefficients at the macroscopic level are derived from considerations at the cellular scale. For instance, the particular response of a single cell to chemical cues turns out to have a strong effect on collective motion. Furthermore, the bottom-up scaling allows us to perform preliminary mathematical analysis and write efficient numerical schemes. This model is intended as a predictive tool for the investigation of bacterial collective motion.

  5. The appropriateness of XML for diagnostic description

    Energy Technology Data Exchange (ETDEWEB)

    Neto, A. [Associacao Euratom/IST, Centro de Fusao Nuclear, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal)], E-mail: andre.neto@cfn.ist.utl.pt; Lister, J.B. [CRPP-EPFL, Association EURATOM-Confederation Suisse, 1015 Lausanne (Switzerland); Fernandes, H. [Associacao Euratom/IST, Centro de Fusao Nuclear, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal); Yonekawa, I. [JAEA, Japan Atomic Energy Agency Naka (Japan); Varandas, C.A.F. [Associacao Euratom/IST, Centro de Fusao Nuclear, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal)

    2007-10-15

    A standard for the self-description of fusion plasma diagnostics will be required in the near future. The motivation is to maintain and organize the information on all the components of a laboratory experiment, from the hardware to the access security, to save time and money. Since there is no existing standard to organize this kind of information, every EU Association stores and organizes each experiment in different ways. This can lead to severe problems when the particular organization schema is poorly documented. Standardization is the key to solve these problems. From the commercial information on the diagnostic (component supplier; component price) to the hardware description (component specifications; drawings) to the operation of the equipment (finite state machines) through change control (who changed what and when) and internationalization (information at least in English and a local language). This problem will be met on the ITER project, for which a solution is essential. A strong candidate solution is the Extensible Markup Language (XML). In this paper, a review of the current status of XML related technologies will be presented.

  6. Initial rheological description of high performance concretes

    Directory of Open Access Journals (Sweden)

    Alessandra Lorenzetti de Castro

    2006-12-01

    Full Text Available Concrete is defined as a composite material and, in rheological terms, it can be understood as a concentrated suspension of solid particles (aggregates in a viscous liquid (cement paste. On a macroscopic scale, concrete flows as a liquid. It is known that the rheological behavior of the concrete is close to that of a Bingham fluid and two rheological parameters regarding its description are needed: yield stress and plastic viscosity. The aim of this paper is to present the initial rheological description of high performance concretes using the modified slump test. According to the results, an increase of yield stress was observed over time, while a slight variation in plastic viscosity was noticed. The incorporation of silica fume showed changes in the rheological properties of fresh concrete. The behavior of these materials also varied with the mixing procedure employed in their production. The addition of superplasticizer meant that there was a large reduction in the mixture's yield stress, while plastic viscosity remained practically constant.

  7. Biowaiver monographs for immediate release solid oral dosage forms: acetaminophen (paracetamol).

    OpenAIRE

    Kalantzi, L; Reppas, C; Dressman, J B; Amidon, G L; Junginger, H E; Midha, K.K.; Shah, V. P.; Stavchansky, S A; Barends, Dirk M.

    2006-01-01

    Literature data are reviewed on the properties of acetaminophen (paracetamol) related to the biopharmaceutics classification system (BCS). According to the current BCS criteria, acetaminophen is BCS Class III compound. Differences in composition seldom, if ever, have an effect on the extent of absorption. However, some studies show differences in rate of absorption between brands and formulations. In particular, sodium bicarbonate, present in some drug products, was reported to give an increa...

  8. SNF AGING SYSTEM DESCRIPTION DOCUMENT

    Energy Technology Data Exchange (ETDEWEB)

    L.L. Swanson

    2005-04-06

    The purpose of this system description document (SDD) is to establish requirements that drive the design of the spent nuclear fuel (SNF) aging system and associated bases, which will allow the design effort to proceed. This SDD will be revised at strategic points as the design matures. This SDD identifies the requirements and describes the system design, as it currently exists, with emphasis on attributes of the design provided to meet the requirements. This SDD is an engineering tool for design control; accordingly, the primary audience and users are design engineers. This SDD is part of an iterative design process. It leads the design process with regard to the flow down of upper tier requirements onto the system. Knowledge of these requirements is essential in performing the design process. The SDD follows the design with regard to the description of the system. The description provided in the SDD reflects the current results of the design process. Throughout this SDD, the term aging cask applies to vertical site-specific casks and to horizontal aging modules. The term overpack is a vertical site-specific cask that contains a dual-purpose canister (DPC) or a disposable canister. Functional and operational requirements applicable to this system were obtained from ''Project Functional and Operational Requirements'' (F&OR) (Curry 2004 [DIRS 170557]). Other requirements that support the design process were taken from documents such as ''Project Design Criteria Document'' (PDC) (BSC 2004 [DES 171599]), ''Site Fire Hazards Analyses'' (BSC 2005 [DIRS 172174]), and ''Nuclear Safety Design Bases for License Application'' (BSC 2005 [DIRS 171512]). The documents address requirements in the ''Project Requirements Document'' (PRD) (Canori and Leitner 2003 [DIRS 166275]). This SDD includes several appendices. Appendix A is a Glossary; Appendix B is a list of key system charts

  9. Biowaiver monographs for immediate release solid oral dosage forms: ethambutol dihydrochloride.

    Science.gov (United States)

    Becker, C; Dressman, J B; Amidon, G L; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2008-04-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing ethambutol dihydrochloride as the only active pharmaceutical ingredient (API) are reviewed. Ethambutol dihydrochloride is a Biopharmaceutics Classification System (BCS) Class III drug with permeability properties approaching the border between BCS Class I and III. BE problems of ethambutol formulations containing different excipients and different dosages forms have not been reported and hence the risk of bioinequivalence caused by excipients is low. Ethambutol has a narrow therapeutic index related to ocular toxicity. However, as long as the prescribers' information of the test product stipulates the need for regular monitoring of ocular toxicity, the additional patient risk is deemed acceptable. It is concluded that a biowaiver can be recommended for IR solid oral dosage forms provided that the test product (a) contains only excipients present in ethambutol IR solid oral drug products approved in ICH or associated countries, for instance as presented in this paper, (b) complies with the criteria for "very rapidly dissolving" and (c) has a prescribers' information indicating the need for testing the patient's vision prior to initiating ethambutol therapy and regularly during therapy.

  10. Biowaiver monographs for immediate release solid oral dosage forms: diclofenac sodium and diclofenac potassium.

    Science.gov (United States)

    Chuasuwan, B; Binjesoh, V; Polli, J E; Zhang, H; Amidon, G L; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2009-04-01

    Literature data are reviewed regarding the scientific advisability of allowing a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing either diclofenac potassium and diclofenac sodium. Within the biopharmaceutics classification system (BCS), diclofenac potassium and diclofenac sodium are each BCS class II active pharmaceutical ingredients (APIs). However, a biowaiver can be recommended for IR drug products of each salt form, due to their therapeutic use, therapeutic index, pharmacokinetic properties, potential for excipient interactions, and performance in reported BE/bioavailability (BA) studies, provided: (a) test and comparator contain the same diclofenac salt; (b) the dosage form of the test and comparator is identical; (c) the test product contains only excipients present in diclofenac drug products approved in ICH or associated countries in the same dosage form, for instance as presented in this paper; (d) test drug product and comparator dissolve 85% in 30 min or less in 900 mL buffer pH 6.8, using the paddle apparatus at 75 rpm or the basket apparatus at 100 rpm; and (e) test product and comparator show dissolution profile similarity in pH 1.2, 4.5, and 6.8.

  11. Theory buried under heavy description

    Directory of Open Access Journals (Sweden)

    Vivian B. Martin Ph.D.

    2010-12-01

    Full Text Available In journalism when a reporter puts the main news or point of the story deep down in the text, we say she’s buried the lead, the lead being the main point of the story and usually the first paragraph. In Children in Genocide: extreme traumatization and affect regulation, psychoanalyst Suzanne Kaplan buries her theory. Her study of the after effects of trauma among Holocaust survivors who were children during their persecution and survivors of atrocities during the Rwandan atrocities of the 1990s, is filled with highly descriptive material from the many interviews that serve as data. An interesting grounded theory is peeking out from under all the disciplinary discourse and historical background one must read through to get to what grounded theory readers will consider the juicy parts: concepts on affect regulation in trauma survivors.

  12. A description of Ternate Malay

    Directory of Open Access Journals (Sweden)

    Betty Litamahuputty

    2012-10-01

    Full Text Available Ternate Malay is a local variety of Malay in Ternate, a small island in the Maluku Utara province in eastern Indonesia. The majority of speakers live in Ternate town, where it serves as mother tongue as well as a means of communication between people of various ethnic and linguistic backgrounds. In the last few decades there is a growing scholarly interest in local Malay varieties, particularly in the eastern part of Indonesia. This article is a short description of Ternate Malay based on the idea that words in Ternate Malay receive their meaning in the combination with other words and that the linguistic context as well as the non-linguistic situation in which they occur, determine the most suitable interpretation of utterances. It is shown how certain words facilitate the determination of the interpretation.

  13. Do children prefer mentalistic descriptions?

    Science.gov (United States)

    Dore, Rebecca A; Lillard, Angeline S

    2014-01-01

    Against a long tradition of childhood realism (Piaget, 1929), A. S. Lillard and J. H. Flavell (1990) found that 3-year-olds prefer to characterize people by their mental states (beliefs, desires, emotions) than by their visible behaviors. In this exploratory study, we extend this finding to a new cohort of 3-year-olds, examine how these preferences change from 3-4 years, and explore relationships with theory of mind and parental mind-mindedness. The results showed a developmental change and a possible cohort difference: at 3 years, children in the sample preferred behavioral descriptions, although by 4 years of age, they preferred mentalistic ones. Interestingly, mentalistic preferences were unrelated to theory of mind or parental mind-mindedness, concurrently or over time. Perspective-taking skills at 3 years, however, predicted an increase in mentalistic responses from 3 years to 4 years. Possible explanations for each finding are discussed.

  14. Develop your presentation skills

    CERN Document Server

    Theobald, Theo

    2016-01-01

    Going beyond handling nerves and presenting PowerPoint slides, the third edition of "Develop Your Presentation Skills "offers practical advice on developing a captivating presentation, constructing compelling content, and boosting self-confidence. The book includes three new chapters on delivering a "stripped down"presentation, using new media to engage with the audience, and handling being asked to present on short notice."

  15. Teaching Presentation Skills

    Science.gov (United States)

    Baker, William H.; Thompson, Michael P.

    2004-01-01

    Effective teaching of presentation skills focuses on the most important element of the presentation--the message itself. Some instructors place the heaviest emphasis on the messenger (the presenter) and focus their presentation feedback on all the presenter is doing wrong--saying "um," gesturing awkwardly, and so forth. When students receive this…

  16. Review of the monograph Mathematical Treatment and Application of Uncertain In-formation

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@The present age is an informational one. Treating the information has become an important step for people to make quantitative analysis in ordinary life, production, scientific study, etc. People have already obtained rich experience and knowledge about treating certain informa-tion. And this is just called classical mathematics. In order to represent and treat uncertain information (random in-formation, fuzzy information, grey information and unas-certained information), uncertain mathematics has ap-peared correspondingly (probability statistics, fuzzy math ematics, grey mathematics and unascertained mathemat- ics). Probability statistics[1], fuzzy mathematic[2], grey mathematics[3] and unascertained mathematics[4] are used to represent and treat random information, fuzzy informa-tion, grey information and unascertained information, respectively. If information with only one uncertainty is named mono-information, then probability statistics, fuz-zy mathematics, grey mathematics and unascertained mathematics are all used to represent and treat the mono- information.

  17. Biowaiver monographs for immediate-release solid oral dosage forms: ketoprofen.

    Science.gov (United States)

    Shohin, Igor E; Kulinich, Julia I; Ramenskaya, Galina V; Abrahamsson, Bertil; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Groot, D W; Barends, Dirk M; Dressman, Jennifer B

    2012-10-01

    Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing ketoprofen are reviewed. Ketoprofen's solubility and permeability, its therapeutic use and therapeutic index, pharmacokinetic properties, data related to the possibility of excipient interactions, and reported BE/bioavailability (BA)/dissolution data were taken into consideration. The available data suggest that according to the current Biopharmaceutics Classification System (BCS) and all current guidances, ketoprofen is a weak acid that would be assigned to BCS Class II. The extent of ketoprofen absorption seems not to depend on formulation or excipients, so the risk of bioinequivalence in terms of area under the curve is very low, but the rate of absorption (i.e., BE in terms of peak plasma concentration, C(max) ) can be altered by formulation. Current in vitro dissolution methods may not always reflect differences in terms of C(max) for BCS Class II weak acids; however, such differences in absorption rate are acceptable for ketoprofen with respect to patient risks. As ketoprofen products may be taken before or after meals, the rate of absorption cannot be considered crucial to drug action. Therefore, a biowaiver for IR ketoprofen solid oral dosage form is considered feasible, provided that (a) the test product contains only excipients present also in IR solid oral drug products containing ketoprofen, which are approved in International Conference on Harmonisation or associated countries, for instance, as presented in this paper; (b) both the test drug product and the comparator dissolve 85% in 30 min or less in pH 6.8 buffer; and (c) test product and comparator show dissolution profile similarity in pH 1.2, 4.5, and 6.8. When one or more of these conditions are not fulfilled, BE should be established in vivo.

  18. Crystallography: past and present

    Science.gov (United States)

    Hodeau, J.-L.; Guinebretiere, R.

    2007-12-01

    structure (chemical order, anisotropy, charge transfer, magnetic order) versus an external parameter like temperature, pressure, magnetic or electric field. Modern crystallography is also extended to the study of very small crystals, powders, ill-ordered or non-crystallized materials. Thus presently, crystallography is concerned with any solid that “scatters” an incident beam. Nevertheless, as quoted by A. Guinier, “the problems facing crystallographers have only changed, ... new ones have appeared which require reflection and imagination, ... and which in turn may still bring much joy to all those who like crystallography” [4]. Such developments open up crystallography to modern materials like artificial ones and nanostructures with low- and/or multi-scaled-periodicities and/or extremely small “crystal size” and to materials of the “real world”, with mixtures of phases and/or amorphous contribution and/or defects, a common characteristic of ancient materials analysed in patrimonial research. In our contribution we will show by selected examples that these improvements were allowed (i) by the use of powerful sources, apparatus and detectors which allow micro-diffraction, in-situ diffraction, spectroscopy, resonant scattering, inelastic scattering, coherent scattering, (ii) by the development of methods like diffraction anomalous fine structure (DAFS), pair distribution function (PDF), simulated annealing, single object reconstruction, (iii) by combination of scattering and spectroscopy and by combination of scattering and microscopy. Such combination of different approaches is very efficient and, as said by H. Curien at the IUCr Bordeaux Congress in 1990, “in crystallography, there is a constant alternation between the crystal space and its associated reciprocal space, ... the alternation between experiment and model building is another feature of crystallography activity ..., the crystallographer relies both on his computer and on his diffractometer

  19. A statistical mechanical description of biomolecular hydration

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    We present an efficient and accurate theoretical description of the structural hydration of biological macromolecules. The hydration of molecules of almost arbitrary size (tRNA, antibody-antigen complexes, photosynthetic reaction centre) can be studied in solution and in the crystal environment. The biomolecular structure obtained from x-ray crystallography, NMR, or modeling is required as input information. The structural arrangement of water molecules near a biomolecular surface is represented by the local water density analogous to the corresponding electron density in an x-ray diffraction experiment. The water-density distribution is approximated in terms of two- and three-particle correlation functions of solute atoms with water using a potentials-of-mean-force expansion.

  20. Demonstration Advanced Avionics System (DAAS) function description

    Science.gov (United States)

    Bailey, A. J.; Bailey, D. G.; Gaabo, R. J.; Lahn, T. G.; Larson, J. C.; Peterson, E. M.; Schuck, J. W.; Rodgers, D. L.; Wroblewski, K. A.

    1982-01-01

    The Demonstration Advanced Avionics System, DAAS, is an integrated avionics system utilizing microprocessor technologies, data busing, and shared displays for demonstrating the potential of these technologies in improving the safety and utility of general aviation operations in the late 1980's and beyond. Major hardware elements of the DAAS include a functionally distributed microcomputer complex, an integrated data control center, an electronic horizontal situation indicator, and a radio adaptor unit. All processing and display resources are interconnected by an IEEE-488 bus in order to enhance the overall system effectiveness, reliability, modularity and maintainability. A detail description of the DAAS architecture, the DAAS hardware, and the DAAS functions is presented. The system is designed for installation and flight test in a NASA Cessna 402-B aircraft.

  1. Aligning Sequences by Minimum Description Length

    Directory of Open Access Journals (Sweden)

    John S. Conery

    2008-01-01

    Full Text Available This paper presents a new information theoretic framework for aligning sequences in bioinformatics. A transmitter compresses a set of sequences by constructing a regular expression that describes the regions of similarity in the sequences. To retrieve the original set of sequences, a receiver generates all strings that match the expression. An alignment algorithm uses minimum description length to encode and explore alternative expressions; the expression with the shortest encoding provides the best overall alignment. When two substrings contain letters that are similar according to a substitution matrix, a code length function based on conditional probabilities defined by the matrix will encode the substrings with fewer bits. In one experiment, alignments produced with this new method were found to be comparable to alignments from CLUSTALW. A second experiment measured the accuracy of the new method on pairwise alignments of sequences from the BAliBASE alignment benchmark.

  2. Integrated Project Management System description. [UMTRAP Project

    Energy Technology Data Exchange (ETDEWEB)

    1987-03-01

    The Uranium Mill Tailings Remedial Action (UMTRA) Project is a Department of Energy (DOE) designated Major System Acquisition (MSA). To execute and manage the Project mission successfully and to comply with the MSA requirements, the UMTRA Project Office ( Project Office'') has implemented and operates an Integrated Project Management System (IPMS). The Project Office is assisted by the Technical Assistance Contractor's (TAC) Project Integration and Control (PIC) Group in system operation. Each participant, in turn, provides critical input to system operation and reporting requirements. The IPMS provides a uniform structured approach for integrating the work of Project participants. It serves as a tool for planning and control, workload management, performance measurement, and specialized reporting within a standardized format. This system description presents the guidance for its operation. Appendices 1 and 2 contain definitions of commonly used terms and abbreviations and acronyms, respectively. 17 figs., 5 tabs.

  3. 一部集中我国研究型医院理论和实践结合发展研究成果的专著%A monograph focus on research the development theory and practice in China researching-type hospital

    Institute of Scientific and Technical Information of China (English)

    王明晓

    2016-01-01

    Some of researching type hospital have been built since 2004 when the concept of researching type hospital was presented by QIN Yinhe, the president of general hospital of PLA. To communication the results of the development theory and practice in China researching-type hospital, a monograph named research type hospital management focused on theory and practice of research type hospital development has been compiled by QIN Yinhe and his team since 2013. The chapters of this monograph involves pandect, plan, leadership, research, human resources, transformation, teaching, nursing, quality, service, ideal, security, logistic, medical ethic, culture and safety and it is the newest and richest monograph which can reflect the general quality of hospital management.%自2004年解放军总医院原院长秦银河教授提出创建研究型医院以来,该理论不断得以丰富深化。以解放军总医院为代表,国内涌现了一批研究型医院。为了集中反映国内研究型医院理论和实践结合的研究成果,2013年开始,由秦银河教授担任主编,集中全国数百名医院管理专家,利用两年的时间,编撰出版了《研究型医院管理学》。该书分为总论、谋划、领导、科研、学科、人才、转化、教学、护理、质量、服务、信念、保障、后勤、医德、文化和安全等18个章节,是目前反映国内医院管理整体水平的一部专著。

  4. Strengthening the Role of Part-Time Faculty in Community Colleges. Example Job Description for Part-Time Faculty: Valencia College--Job Description and Essential Competencies

    Science.gov (United States)

    Center for Community College Student Engagement, 2013

    2013-01-01

    In an effort to support college conversations regarding strengthening the role of part-time faculty, this brief document presents the job description for a Valencia College part-time/adjunct professor (revised as of July 19, 2013). The description includes essential functions, qualifications, and knowledge, skills, and abilities. This is followed…

  5. Words and Maps: Developmental Changes in Mental Models of Spatial Information Acquired from Descriptions and Depictions

    Science.gov (United States)

    Uttal, David H.; Fisher, Joan A.; Taylor, Holly A.

    2006-01-01

    People acquire spatial information from many sources, including maps, verbal descriptions, and navigating in the environment. The different sources present spatial information in different ways. For example, maps can show many spatial relations simultaneously, but in a description, each spatial relation must be presented sequentially. The present…

  6. Session: Parabolic Troughs (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Kutscher, C.

    2008-04-01

    The project description is R and D activities at NREL and Sandia aimed at lowering the delivered energy cost of parabolic trough collector systems and FOA awards to support industry in trought development. The primary objectives are: (1) support development of near-term parabolic trought technology for central station power generation; (2) support development of next-generation trought fields; and (3) support expansion of US trough industry. The major FY08 activities were: (1) improving reflector optics; (2) reducing receiver heat loss (including improved receiver coating and mitigating hydrogen accumulation); (3) measuring collector optical efficiency; (4) optimizing plant performance and reducing cost; (5) reducing plant water consumption; and (6) directly supporting industry needs, including FOA support.

  7. Biowaiver monographs for immediate release solid oral dosage forms: acetaminophen (paracetamol).

    Science.gov (United States)

    Kalantzi, L; Reppas, C; Dressman, J B; Amidon, G L; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S A; Barends, Dirk M

    2006-01-01

    Literature data are reviewed on the properties of acetaminophen (paracetamol) related to the biopharmaceutics classification system (BCS). According to the current BCS criteria, acetaminophen is BCS Class III compound. Differences in composition seldom, if ever, have an effect on the extent of absorption. However, some studies show differences in rate of absorption between brands and formulations. In particular, sodium bicarbonate, present in some drug products, was reported to give an increase in the rate of absorption, probably caused by an effect on gastric emptying. In view of Marketing Authorizations (MAs) given in a number of countries to acetaminophen drug products with rapid onset of action, it is concluded that differences in rate of absorption were considered therapeutically not relevant by the Health Authorities. Moreover, in view of its therapeutic use, its wide therapeutic index and its uncomplicated pharmacokinetic properties, in vitro dissolution data collected according to the relevant Guidances can be safely used for declaring bioequivalence (BE) of two acetaminophen formulations. Therefore, accepting a biowaiver for immediate release (IR) acetaminophen solid oral drug products is considered scientifically justified, if the test product contains only those excipients reported in this paper in their usual amounts and the test product is rapidly dissolving, as well as the test product fulfils the criterion of similarity of dissolution profiles to the reference product.

  8. Biowaiver monographs for immediate-release solid oral dosage forms: stavudine.

    Science.gov (United States)

    Silva, Arthur L L; Cristofoletti, Rodrigo; Storpirtis, Silvia; Sousa, Varley D; Junginger, Hans E; Shah, Vinod P; Stavchansky, Salomon; Dressman, Jennifer B; Barends, Dirk M

    2012-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing stavudine (d4T) are reviewed. According to Biopharmaceutics Classification System (BCS), d4T can be assigned to BCS class I. No problems with BE of IR d4T formulations containing different excipients and produced by different manufacturing methods have been reported and, hence, the risk of bioinequivalence caused by these factors appears to be low. Furthermore, d4T has a wide therapeutic index. It is concluded that a biowaiver is appropriate for IR solid oral dosage forms containing d4T as the single active pharmaceutical ingredient (API) provided that (a) the test product contains only excipients present in the IR d4T drug products that have been approved in a number of countries for the same dosage form, and (b) both test product and its comparator are either "very rapidly dissolving" or "rapidly dissolving" with similarity of dissolution profiles demonstrated at pH 1.2, 4.5, and 6.8.

  9. Biowaiver monographs for immediate release solid oral dosage forms: Doxycycline hyclate.

    Science.gov (United States)

    Jantratid, E; Strauch, S; Becker, C; Dressman, J B; Amidon, G L; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2010-04-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing doxycycline hyclate are reviewed. According to the Biopharmaceutics Classification System (BCS), doxycycline hyclate can be assigned to BCS Class I. No problems with BE of IR doxycycline formulations containing different excipients and produced by different manufacturing methods have been reported and hence the risk of bioinequivalence caused by these factors appears to be low. Doxycycline has a wide therapeutic index. Further, BCS-based dissolution methods have been shown to be capable of identifying formulations which may dissolve too slowly to generate therapeutic levels. It is concluded that a biowaiver is appropriate for IR solid oral dosage forms containing doxycycline hyclate as the single Active Pharmaceutical Ingredient (API) provided that (a) the test product contains only excipients present in doxycycline hyclate IR solid oral drug products approved in the International Conference on Harmonization (ICH) or associated countries; and (b) the comparator and the test products comply with the BCS criteria for "very rapidly dissolving" or, alternatively, when similarity of the dissolution profiles can be demonstrated and the two products are "rapidly dissolving.".

  10. Biowaiver monographs for immediate-release solid oral dosage forms: primaquine phosphate.

    Science.gov (United States)

    Nair, Anita; Abrahamsson, Bertil; Barends, Dirk M; Groot, D W; Kopp, Sabine; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2012-03-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing the antimalarial drug primaquine phosphate as the only active pharmaceutical ingredient (API) are reviewed. On the basis of permeability data and solubility studies, primaquine phosphate was found to be "highly soluble" and "highly permeable" API, thus conforming to Class I of the Biopharmaceutical Classification System (BCS). It has a wide therapeutic index. BCS-conform dissolution studies showed the products to be rapidly dissolving. No data pertaining to BE or bioinequivalence of IR primaquine phosphate products could be located in open literature. On the basis of the available data, a biowaiver-procedure-based approval can be recommended for IR solid oral dosage forms of primaquine phosphate, provided the generic product contains excipients present in products already approved by the International Conference on Harmonisation or associated countries in similar amounts and the test and reference products meet the dissolution criteria for "rapidly dissolving" (>85% drug release in 30 min in standard media at pH 1.2, 4.5, and 6.8; similarity factor (f(2)) > 50) or "very rapidly dissolving" products (>85% drug release in 15 min in standard media at pH 1.2, 4.5, and 6.8).

  11. JTEC monograph on biodegradable polymers and plastics in Japan: Research, development, and applications

    Science.gov (United States)

    Lenz, Robert W.

    1995-01-01

    A fact-finding team of American scientists and engineers visited Japan to assess the status of research and development and applications in biodegradable polymers. The visit was sponsored by the National Science Foundation and industry. In Japan, the team met with representatives of 31 universities, government ministries and institutes, companies, and associations. Japan's national program on biodegradable polymers and plastics evaluates new technologies, testing methods, and potential markets for biodegradables. The program is coordinated by the Biodegradable Plastics Society of Japan, which seeks to achieve world leadership in biodegradable polymer technology and identify commercial opportunities for exploiting this technology. The team saw no major new technology breakthroughs. Japanese scientists and engineers are focusing on natural polymers from renewable resources, synthetic polymers, and bacterially-produced polymers such as polyhydroxyalkanoates, poly(amino acids), and polysaccharides. The major polymers receiving attention are the Zeneca PHBV copolymers, Biopol(registered trademark), poly(lactic acid) from several sources, polycaprolactone, and the new synthetic polyester, Bionolle(registered trademark), from Showa High Polymer. In their present state of development, these polymers all have major deficiencies that inhibit their acceptance for large-scale applications.

  12. Biowaiver monograph for immediate-release solid oral dosage forms: fluconazole.

    Science.gov (United States)

    Charoo, Naseem; Cristofoletti, Rodrigo; Graham, Alexandra; Lartey, Paul; Abrahamsson, Bertil; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James; Shah, Vinod P; Dressman, Jennifer

    2014-12-01

    Literature data pertaining to the decision to allow a waiver of in vivo bioequivalence (BE) testing requirements for the approval of immediate release (IR) solid oral dosage forms containing fluconazole as the only active pharmaceutical ingredient (API) are reviewed. The decision is based on solubility, dissolution, permeability, therapeutic index, pharmacokinetic parameters, pharmacodynamic properties, and other relevant data. BE/bioavailability (BA) problems and drug-excipients interaction data were also reviewed and taken into consideration. According to the biopharmaceutics classification system (BCS), fluconazole in polymorphic forms II and III is a BCS class I drug and has a wide therapeutic index. BE of test formulations from many different manufacturers containing different excipients confirmed that the risk of bioinequivalence because of formulation and manufacturing factors is low. It was inferred that risk can be further reduced if in vitro studies are performed according to biowaiver guidelines. Thus, it is concluded that a biowaiver can be recommended for fluconazole IR dosage forms if (a) fluconazole is present as polymorphic form II or III or any other form/mixture showing high solubility, (b) the selection of excipients be limited to those found in IR drug products approved in International Conference on Harmonisation (ICH) countries for the same dosage form and used in their usual amounts, and (c) both the test and comparator dosage form are very rapidly dissolving, or, rapidly dissolving throughout the shelf life with similar dissolution profiles at pH 1.2, 4.5, and 6.8.

  13. Clinical roundtable monograph: unmet needs in the treatment of chronic lymphocytic leukemia: integrating a targeted approach.

    Science.gov (United States)

    O'Brien, Susan M; Furman, Richard R; Byrd, John C; Smith, Ashbel

    2014-01-01

    Chronic lymphocytic leukemia (CLL) is the most frequently diagnosed hematologic malignancy in the United States. Although several features can be useful in the diagnosis of CLL, the most important is the immunophenotype.Two staging systems--the Binet system and the Rai classification--are used to assess risk. After diagnosis, the first major therapeutic decision is when to initiate therapy, as a watchful waiting approach is often appropriate for patients with asymptomatic disease. Once a patient has met the criteria for treatment, the choice of therapy is the next major decision. Younger patients (<65 years) often receive more aggressive treatment that typically consists of cytotoxic chemotherapy. There is a great unmet need concerning treatment of older patients with CLL, who often present with more comorbid conditions that can decrease their ability to tolerate particular regimens. The current standard of care for older patients with CLL is rituximab plus chlorambucil. The concept of targeted agents is currently an area of intense interest in CLL. The Bruton’s tyrosine kinase inhibitor ibrutinib is the targeted agent that is furthest along in clinical development. It is associated with an overall survival rate of 83%. Idelalisib targets the phosphatidyl inositol 3-kinase and is under evaluation in pivotal trials. Targeted agents offer much promise in terms of efficacy, toxicity, and oral availability. They will change the management of patients with CLL.

  14. Automatic SAR/optical cross-matching for GCP monograph generation

    Science.gov (United States)

    Nutricato, Raffaele; Morea, Alberto; Nitti, Davide Oscar; La Mantia, Claudio; Agrimano, Luigi; Samarelli, Sergio; Chiaradia, Maria Teresa

    2016-10-01

    Ground Control Points (GCP), automatically extracted from Synthetic Aperture Radar (SAR) images through 3D stereo analysis, can be effectively exploited for an automatic orthorectification of optical imagery if they can be robustly located in the basic optical images. The present study outlines a SAR/Optical cross-matching procedure that allows a robust alignment of radar and optical images, and consequently to derive automatically the corresponding sub-pixel position of the GCPs in the optical image in input, expressed as fractional pixel/line image coordinates. The cross-matching in performed in two subsequent steps, in order to gradually gather a better precision. The first step is based on the Mutual Information (MI) maximization between optical and SAR chips while the last one uses the Normalized Cross-Correlation as similarity metric. This work outlines the designed algorithmic solution and discusses the results derived over the urban area of Pisa (Italy), where more than ten COSMO-SkyMed Enhanced Spotlight stereo images with different beams and passes are available. The experimental analysis involves different satellite images, in order to evaluate the performances of the algorithm w.r.t. the optical spatial resolution. An assessment of the performances of the algorithm has been carried out, and errors are computed by measuring the distance between the GCP pixel/line position in the optical image, automatically estimated by the tool, and the "true" position of the GCP, visually identified by an expert user in the optical images.

  15. Edited Volumes, Monographs, and Book Chapters in the Book Citation Index (BCI) and Science Citation Index (SCI, SoSCI, A&HCI)

    CERN Document Server

    Leydesdorff, Loet

    2012-01-01

    In 2011, Thomson-Reuters introduced the Book Citation Index (BCI) as part of the Science Citation Index (SCI). The interface of the Web of Science version 5 enables users to search for both "Books" and "Book Chapters" as new categories. Books and book chapters, however, were always among the cited references, and book chapters have been included in the database since 2005. We explore the two categories with both BCI and SCI, and in the sister databases for the social sciences (SoSCI) and the arts and humanities (A&HCI). Book chapters in edited volumes can be highly cited. Books contain many citing references, but are relatively less cited. We suggest that this may find its origin in the slower circulation of books then of journal articles. It is possible to distinguish scientometrically between monographs and edited volumes among the "Books". Monographs may be underrated in terms of citation impact or overrated using publication performance indicators because individual chapters are counted separately as ...

  16. Edited volumes, monographs and book chapters in the Book Citation Index (BKCI and Science Citation Index (SCI, SoSCI, A&HCI

    Directory of Open Access Journals (Sweden)

    Loet Leydesdorff

    2012-01-01

    Full Text Available In 2011, Thomson-Reuters introduced the Book Citation Index (BKCI as part of the Science Citation Index (SCI. The interface of the Web of Science version 5 enables users to search for both ′Books′ and ′Book Chapters′ as new categories. Books and book chapters, however, were always among the cited references, and book chapters have been included in the database since 2005. We explore the two categories with both BKCI and SCI, and in the sister social sciences (SoSCI and the arts & humanities (A&HCI databases. Book chapters in edited volumes can be highly cited. Books contain many citing references but are relatively less cited. This may find its origin in the slower circulation of books than of journal articles. It is possible to distinguish between monographs and edited volumes among the ′Books′ scientometrically. Monographs may be underrated in terms of citation impact or overrated using publication performance indicators because individual chapters are counted as contributions separately in terms of articles, reviews, and/or book chapters.

  17. Measures of abdominal adiposity and the risk of stroke: the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) study.

    Science.gov (United States)

    Bodenant, Marie; Kuulasmaa, Kari; Wagner, Aline; Kee, Frank; Palmieri, Luigi; Ferrario, Marco M; Montaye, Michèle; Amouyel, Philippe; Dallongeville, Jean

    2011-10-01

    Excess fat accumulates in the subcutaneous and visceral adipose tissue compartments. We tested the hypothesis that indicators of visceral adiposity, namely, waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR), are better predictors of stroke risk than body mass index (BMI). The association of BMI, WC, WHR, and WHtR with stroke was assessed in 31,201 men and 23,516 women, free of vascular disease at baseline, from the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) study. During a mean follow-up of 11 years, 1130 strokes were recorded. Relative risks (95% CI) were calculated by Cox regression after stratification for center and adjustment for age, smoking, educational level, alcohol consumption, hypertension, diabetes, total cholesterol, high-density lipoprotein cholesterol, and BMI and model fit was assessed using log-likelihoods. BMI, WC, WHR, and WHtR were associated with the risk of stroke in men. After full adjustment including BMI, the relative risks for stroke remained significant for WC (1.19 [1.02 to 1.34] per 1 SD increase in WC), WHR (1.14 [1.03 to 1.26]), and WHtR (1.50 [1.28 to 1.77]). Among women, the extent of the associations with stroke risk was similar for WHtR (1.31 [1.04 to 1.65]), WC (1.19 [0.96 to 1.47]), and WHR (1.08 [0.97 to 1.22]). Further analyses by World Health Organization obesity categories showed that WC, WHR, and WHtR were associated with the risk of stroke also in lean men and women (BMI<25 kg/m2), independently of confounders, cardiovascular risk factors, and BMI. Indicators of abdominal adiposity, especially WHtR, are more strongly associated with stroke risk than BMI. These results emphasize the importance of measuring abdominal adiposity, especially in lean subjects.

  18. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    Science.gov (United States)

    Szer, Jeff; Hill, Anita; Weitz, Ilene Ceil

    2012-11-01

    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disorder characterized by chronic intravascular hemolysis as the primary clinical manifestation and morbidities that include anemia, thrombosis, renal impairment, pulmonary hypertension, and bone marrow failure. The prevalence of the PNH clone (from <1-100% PNH granulocytes) is approximately 16 per million, and careful monitoring is required. The average age of onset of the clinical disease is the early 30s, although it can present at all ages. PNH is caused by the acquisition of a somatic mutation of the gene phosphatidylinositol glycan anchor (PIG-A) in a multipotent hematopoietic stem cell (HSC), with clonal expansion of the mutated HSC. The mutation causes a deficiency in the synthesis of glycosylphosphatidylinositol (GPI). In cells derived from normal HSCs, the complement regulatory proteins CD55 and CD59 are anchored to the hematopoietic cell membrane surface via GPI, protecting the cells from complement-mediated lysis. However, in patients with PNH, these 2 proteins, along with numerous other GPI-linked proteins, are absent from the cell surface of red cells, granulocytes, monocytes, and platelets, resulting in complement-mediated intravascular hemolysis and other complications. Lysis of red blood cells is the most obvious manifestation, but as other cell lineages are also affected, this complement-mediated attack contributes to additional complications, such as thrombosis. Eculizumab, a humanized monoclonal antibody against the C5 complement protein, is the only effective drug therapy for PNH patients. The antibody prevents cleavage of the C5 protein by C5 convertase, in turn preventing generation of C5b-9 and release of C5a, thereby protecting from hemolysis of cells lacking the CD59 surface protein and other complications associated with complement activation. Drs. Ilene C. Weitz, Anita Hill, and Jeff Szer discuss 3 recent cases of patients with PNH.

  19. A monograph of Allantonectria, Nectria, and Pleonectria (Nectriaceae, Hypocreales, Ascomycota) and their pycnidial, sporodochial, and synnematous anamorphs.

    Science.gov (United States)

    Hirooka, Y; Rossman, A Y; Samuels, G J; Lechat, C; Chaverri, P

    2012-03-15

    perithecia are immersed, large ascospores, and peculiar anamorphs that form pycnidia or sporodochia either on their natural substrate or in culture. In this study the evolution of species, morphology, and ecology of the three genera, Allantonectria, Nectria, and Pleonectria, are discussed based on the phylogenetic analyses. In addition, descriptions, illustrations, and keys for identification are presented for the 56 species in Allantonectria, Nectria, and Pleonectria. New species:Nectria argentinensis Hirooka, Rossman & P. Chaverri, Nectria berberidicola Hirooka, Lechat, Rossman, & P. Chaverri, Nectria himalayensis Hirooka, Rossman, & P. Chaverri, Nectria magnispora Hirooka, Rossman, & P. Chaverri, Nectria mariae Hirooka, Fournier, Lechat, Rossman, & P. Chaverri, Nectriapyriformis Hirooka, Rossman & P. Chaverri, Pleonectria boothii Hirooka, Rossman & Chaverri, Pleonectria clavatispora Hirooka, Rossman & P. Chaverri, Pleonectria ilicicola Hirooka, Rossman & P. Chaverri, Pleonectria okinawensis Hirooka, Rossman & P. Chaverri, Pleonectria pseudomissouriensis Hirooka, Rossman & P. Chaverri, Pleonectria quercicola Hirooka, Checa, Areual, Rossman & P. Chaverri, Pleonectria strobi Hirooka, Rossman & P. Chaverri. New combinations:Cosmospora proteae (Marinc., M.J. Wingf. & Crous) Hirooka, Rossman & P. Chaverri, Nectricladiellaviticola (Berk. & M.A. Curtis) Hirooka, Rossman & P. Chaverri, Neocosmospora guarapiensis (Speg.) Hirooka, Samuels, Rossman & P. Chaverri, Neocosmospora rehmiana (Kirschstein) Hirooka, Samuels, Rossman & P. Chaverri, Pleonectria aquifolii (Fr.) Hirooka, Rossman & P. Chaverri, Pleonectria aurigera (Berk. & Rav.) Hirooka, Rossman & P. Chaverri, Pleonectria chlorinella (Cooke) Hirooka, Rossman & P. Chaverri, Pleonectria coryli (Fuckel) Hirooka, Rossman & P. Chaverri, Pleonectria cucurbitula (Tode: Fr.) Hirooka, Rossman & P. Chaverri, Pleonectria lonicerae (Seeler) Hirooka, Rossman & P. Chaverri, Pleonectria rosellinii (Carestia) Hirooka, Rossman & P. Chaverri

  20. A Petri Net Definition of a System Description Language

    DEFF Research Database (Denmark)

    Jensen, Kurt; Kyng, Morten; Madsen, Ole Lehrmann

    1979-01-01

    This paper introduces a language for the description of systems with concurrency, and presents a formal definition of its semantics. The language is based on Delta and the semantic model is an extension of Petri nets with a data part and with expressions attached to transitions and to places....

  1. 2010 National Beneficiary Survey: Methodology and Descriptive Statistics.

    OpenAIRE

    Debra Wright; Gina Livermore; Denise Hoffman; Eric Grau; Maura Bardos

    2012-01-01

    This report presents the sampling design and data collection activities for round 4 (2010) of the Social Security Administration’s National Beneficiary Survey (NBS). It also provides descriptive statistics on working-age individuals receiving Supplemental Security Income and Social Security Disability Insurance benefits, based on the nationally representative sample from the 2010 NBS.

  2. Palliative care services in The Netherlands: a descriptive study.

    NARCIS (Netherlands)

    Francke, A.L.; Kerkstra, A.

    2000-01-01

    In this paper several types of specialized palliative care services in The Netherlands are presented. These include palliative care units in homes for the elderly, in nursing homes, in a general hospital and in an oncology clinic. In addition, a description is given of private hospices and of a home

  3. THEORETICAL DESCRIPTION OF NEAR EDGE EELS AND XAS SPECTRA

    NARCIS (Netherlands)

    SAWATZKY, GA

    1991-01-01

    In this communication I want to briefly describe the contents of the talk I presented at the lake Tahoe EELS conference. Since most of what I talked about has or will appear in print in another form, I will restrict myself to very brief descriptions of in my view relevant basic ideas and supply a

  4. THEORETICAL DESCRIPTION OF NEAR EDGE EELS AND XAS SPECTRA

    NARCIS (Netherlands)

    SAWATZKY, GA

    1991-01-01

    In this communication I want to briefly describe the contents of the talk I presented at the lake Tahoe EELS conference. Since most of what I talked about has or will appear in print in another form, I will restrict myself to very brief descriptions of in my view relevant basic ideas and supply a li

  5. Water Resources Research Grant Program project descriptions, fiscal year 1985

    Science.gov (United States)

    ,

    1985-01-01

    Information on each of the 24 projects funded by the U.S. Geological Survey in FY 1985 under section 105 of Public Law 93-242 (the Water Resources Research Act of 1984) is presented, including the grant number, organization, the period of performance, and a brief description of the work to be carried out. (Lantz-PTT)

  6. Technical descriptions of ten irrigation technologies for conserving energy

    Energy Technology Data Exchange (ETDEWEB)

    Harrer, B.J.; Wilfert, G.L.

    1983-05-01

    Technical description of ten technologies which were researched to save energy in irrigated agriculture are presented. These technologies are: well design and development ground water supply system optimization, column and pump redesign, variable-speed pumping, pipe network optimization, reduced-pressure center-pivot systems, low-energy precision application, automated gated-pipe system, computerized irrigation scheduling, and instrumented irrigation scheduling. (MHR)

  7. 软件体系结构描述研究与进展%Overview on Software Architecture Description

    Institute of Scientific and Technical Information of China (English)

    孙昌爱; 金茂忠

    2003-01-01

    Recently,Software Architecture has become one focus in software Engineering community,and a key issue to successful large-scale software development. Software Architecture Description forms the base for architectural construction, evolution, verification, analysis, maintenance and architecture-driven software development. The concept related with Software Architecture Description is introduced,and Architecture Description Language and Typical Architecture Description Method are discussed in the paper. At the same time ,the industrial standards for Software Architecture Description,such as IEEE P1471 and Rational RAS-ADS,is also introduced. Finally,the conclusion and envision for Software Architecture Description are present in the paper.

  8. Description and Analysis Pattern for Theses and Dissertations

    Directory of Open Access Journals (Sweden)

    Sirous Alidousti

    2009-07-01

    Full Text Available Dissertations and theses that are generated in course of research at PhD and Masters levels are considered to be important scientific documents in every country. Data description and analysis of such documents collected together, could automatically - especially when compared with data from other resources - provide new information that is very valuable. Nevertheless, no comprehensive, integrated pattern exists for such description and analysis. The present paper offers the findings of a research conducted for devising an information analysis pattern for dissertations and theses. It also puts forward information categories derived from such documents that could be described and analyzed.

  9. LEXICAL CHOICES: THE DESCRIPTION OF WOMEN IN LITERARY DISCOURSE

    Directory of Open Access Journals (Sweden)

    Elis de Almeida Cardoso Caretta

    2013-06-01

    Full Text Available This paper aims to show, through the lexical choices made by an author, what aesthetic effect achieved in the description of women in literary discourse. For this, we take as example of descriptive passages important novels published in the nineteenth century, taking into consideration the significance and value of notional words selected, and the expressiveness of semantic networks, with the intention of verifying how the lexical choices featuring female characters, placing them in the context of the work and in your universe. From the analysis presented is intended to show that the works of renowned Brazilian literature can be worked in the classroom with linguistic approach.

  10. Formalized Description of Distributed Denial of Service Attack

    Institute of Scientific and Technical Information of China (English)

    杜彦辉; 马锐; 刘玉树

    2004-01-01

    The distributed denial of service (DDoS) attack is one of the dangers in intrusion modes. It's difficult to defense and can cause serious damage to the system. Based on a careful study of the attack principles and characteristics, an object-oriented formalized description is presented, which contains a three-level framework and offers full specifications of all kinds of DDoS modes and their features and the relations between one another. Its greatest merit lies in that it contributes to analyzing, checking and judging DDoS. Now this formalized description has been used in a special IDS and it works very effectively.

  11. Advanced Transport Operating System (ATOPS) control display unit software description

    Science.gov (United States)

    Slominski, Christopher J.; Parks, Mark A.; Debure, Kelly R.; Heaphy, William J.

    1992-01-01

    The software created for the Control Display Units (CDUs), used for the Advanced Transport Operating Systems (ATOPS) project, on the Transport Systems Research Vehicle (TSRV) is described. Module descriptions are presented in a standardized format which contains module purpose, calling sequence, a detailed description, and global references. The global reference section includes subroutines, functions, and common variables referenced by a particular module. The CDUs, one for the pilot and one for the copilot, are used for flight management purposes. Operations performed with the CDU affects the aircraft's guidance, navigation, and display software.

  12. The present status of the Shanghai electron beam ion trap

    Institute of Scientific and Technical Information of China (English)

    GUO Pan-Lin; WANG Xin-Cheng; ZHU Xi-Kai; JIANG Di-Kui; HUTTON R; ZOU Ya-Ming; HU Wei; GONG Pei-Rong; LU Di; HE Mian-Hong; WU Shimin; YAO Ke; HUANG Min; ZHANG Xue-Mei

    2005-01-01

    In this report, an introduction to the structure of Shanghai EBIT, a brief description of the status of Shanghai EBIT project, and a short discussion of the first results of Shanghai EBIT are presented.

  13. Probabilistic description of traffic flow

    Science.gov (United States)

    Mahnke, R.; Kaupužs, J.; Lubashevsky, I.

    2005-03-01

    A stochastic description of traffic flow, called probabilistic traffic flow theory, is developed. The general master equation is applied to relatively simple models to describe the formation and dissolution of traffic congestions. Our approach is mainly based on spatially homogeneous systems like periodically closed circular rings without on- and off-ramps. We consider a stochastic one-step process of growth or shrinkage of a car cluster (jam). As generalization we discuss the coexistence of several car clusters of different sizes. The basic problem is to find a physically motivated ansatz for the transition rates of the attachment and detachment of individual cars to a car cluster consistent with the empirical observations in real traffic. The emphasis is put on the analogy with first-order phase transitions and nucleation phenomena in physical systems like supersaturated vapour. The results are summarized in the flux-density relation, the so-called fundamental diagram of traffic flow, and compared with empirical data. Different regimes of traffic flow are discussed: free flow, congested mode as stop-and-go regime, and heavy viscous traffic. The traffic breakdown is studied based on the master equation as well as the Fokker-Planck approximation to calculate mean first passage times or escape rates. Generalizations are developed to allow for on-ramp effects. The calculated flux-density relation and characteristic breakdown times coincide with empirical data measured on highways. Finally, a brief summary of the stochastic cellular automata approach is given.

  14. Content of system design descriptions

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-10-01

    A System Design Description (SDD) describes the requirements and features of a system. This standard provides guidance on the expected technical content of SDDs. The need for such a standard was recognized during efforts to develop SDDs for safety systems at DOE Hazard Category 2 nonreactor nuclear facilities. Existing guidance related to the corresponding documents in other industries is generally not suitable to meet the needs of DOE nuclear facilities. Across the DOE complex, different contractors have guidance documents, but they vary widely from site to site. While such guidance documents are valuable, no single guidance document has all the attributes that DOE considers important, including a reasonable degree of consistency or standardization. This standard is a consolidation of the best of the existing guidance. This standard has been developed with a technical content and level of detail intended to be most applicable to safety systems at DOE Hazard Category 2 nonreactor nuclear facilities. Notwithstanding that primary intent, this standard is recommended for other systems at such facilities, especially those that are important to achieving the programmatic mission of the facility. In addition, application of this standard should be considered for systems at other facilities, including non-nuclear facilities, on the basis that SDDs may be beneficial and cost-effective.

  15. XML Translator for Interface Descriptions

    Science.gov (United States)

    Boroson, Elizabeth R.

    2009-01-01

    A computer program defines an XML schema for specifying the interface to a generic FPGA from the perspective of software that will interact with the device. This XML interface description is then translated into header files for C, Verilog, and VHDL. User interface definition input is checked via both the provided XML schema and the translator module to ensure consistency and accuracy. Currently, programming used on both sides of an interface is inconsistent. This makes it hard to find and fix errors. By using a common schema, both sides are forced to use the same structure by using the same framework and toolset. This makes for easy identification of problems, which leads to the ability to formulate a solution. The toolset contains constants that allow a programmer to use each register, and to access each field in the register. Once programming is complete, the translator is run as part of the make process, which ensures that whenever an interface is changed, all of the code that uses the header files describing it is recompiled.

  16. Action description using point clouds

    Science.gov (United States)

    Liu, Wenping; Jiang, Yongfeng; Wang, Haili; Zhang, Liang

    2017-06-01

    An action description method named as Motion History Point Cloud (MHPC) is proposed in this paper. MHPC compresses an action into a three-dimensional point cloud in which depth information is required. In MHPC, the spatial coordinate channels are used to record the motion foreground, and the color channels are used to record the temporal variation. Due to containing depth information, MHPC can depict an action more meticulous than Motion History Image (MHI). MHPC can serve as a pre-processed input for various classification methods, such as Bag of Words and Deep Learning. An action recognition scheme is provided as an application example of MHPC. In this scheme, Harris3D detector and Fast Point Feature Histogram (FPFH) are used to extract and describe features from MHPC. Then, Bag of Words and multiple classification Support Vector Machine (SVM) are used to do action recognition. The experiments show that rich features can be extracted from MHPC to support the subsequent action recognition even after downsampling. The feasibility and effectiveness of MHPC are also verified by comparing the above scheme with two similar methods.

  17. A taxonomic monograph of the genus Tylodinus Champion (Coleoptera: Curculionidae: Cryptorhynchinae: Tylodina) of Chiapas, Mexico.

    Science.gov (United States)

    Luna-Cozar, Jesús; Anderson, Robert S; Jones, Robert W; León-Corté, Jorge L

    2014-04-15

    better definition of the taxonomic limits of species and species groups.        Species groups are characterized and taxonomic composition and general distribution and ecological correlates summarized. Diagnoses and distributions are given for all species and ecological information is presented where available. Immature stages, life history and food habits are not known for any of the species. 

  18. Spinal meningiomas in dogs: Description of 8 cases including a novel radiological and histopathological presentation

    Science.gov (United States)

    José-López, Roberto; de la Fuente, Cristian; Pumarola, Martí; Añor, Sonia

    2013-01-01

    Clinical, imaging, and histological features of 8 canine spinal meningiomas, including a cervical cystic meningioma with imaging and intraoperative features of an arachnoid cyst, are described. All meningiomas were histologically classified and graded following the international World Health Organization human classification for tumors. Six meningiomas were located in the cervical spinal cord. Myelography showed intradural/ extramedullary lesions in 3/4 cases. Magnetic resonance imaging revealed hyperintense intradural/extramedullary masses on pre-contrast T1-weighted and T2-weighted images with homogeneous contrast enhancement in 7/8 cases. One dog had a cerebrospinal fluid-filled subarachnoid cavity dorsal to the cervical spinal cord. A spinal arachnoid cyst was diagnosed on imaging, but the histopathological study of the resected tissue revealed a grade I meningothelial cystic meningioma. There were no differences in outcome associated with tumor grade and surgical treatment (6/8). Cystic meningioma should be considered in the differential diagnosis of intraspinal cystic lesions, and biopsy is necessary for definitive diagnosis. PMID:24155414

  19. Irreducible descriptive sets of attributes for information systems

    KAUST Repository

    Moshkov, Mikhail

    2010-01-01

    The maximal consistent extension Ext(S) of a given information system S consists of all objects corresponding to attribute values from S which are consistent with all true and realizable rules extracted from the original information system S. An irreducible descriptive set for the considered information system S is a minimal (relative to the inclusion) set B of attributes which defines exactly the set Ext(S) by means of true and realizable rules constructed over attributes from the considered set B. We show that there exists only one irreducible descriptive set of attributes. We present a polynomial algorithm for this set construction. We also study relationships between the cardinality of irreducible descriptive set of attributes and the number of attributes in S. The obtained results will be useful for the design of concurrent data models from experimental data. © 2010 Springer-Verlag.

  20. Time-dependent density-functional description of nuclear dynamics

    CERN Document Server

    Nakatsukasa, Takashi; Matsuo, Masayuki; Yabana, Kazuhiro

    2016-01-01

    We present the basic concepts and recent developments in the time-dependent density functional theory (TDDFT) for describing nuclear dynamics at low energy. The symmetry breaking is inherent in nuclear energy density functionals (EDFs), which provides a practical description of important correlations at the ground state. Properties of elementary modes of excitation are strongly influenced by the symmetry breaking and can be studied with TDDFT. In particular, a number of recent developments in the linear response calculation have demonstrated their usefulness in description of collective modes of excitation in nuclei. Unrestricted real-time calculations have also become available in recent years, with new developments for quantitative description of nuclear collision phenomena. There are, however, limitations in the real-time approach; for instance, it cannot describe the many-body quantum tunneling. Thus, we treat the quantum fluctuations associated with slow collective motions assuming that time evolution of...

  1. Primary Numbers Database for ATLAS Detector Description Parameters

    CERN Document Server

    Vaniachine, A; Malon, D; Nevski, P; Wenaus, T

    2003-01-01

    We present the design and the status of the database for detector description parameters in ATLAS experiment. The ATLAS Primary Numbers are the parameters defining the detector geometry and digitization in simulations, as well as certain reconstruction parameters. Since the detailed ATLAS detector description needs more than 10,000 such parameters, a preferred solution is to have a single verified source for all these data. The database stores the data dictionary for each parameter collection object, providing schema evolution support for object-based retrieval of parameters. The same Primary Numbers are served to many different clients accessing the database: the ATLAS software framework Athena, the Geant3 heritage framework Atlsim, the Geant4 developers framework FADS/Goofy, the generator of XML output for detector description, and several end-user clients for interactive data navigation, including web-based browsers and ROOT. The choice of the MySQL database product for the implementation provides addition...

  2. General description of circularly symmetric Bessel beams of arbitrary order

    Science.gov (United States)

    Wang, Jia Jie; Wriedt, Thomas; Lock, James A.; Mädler, Lutz

    2016-11-01

    A general description of circularly symmetric Bessel beams of arbitrary order is derived in this paper. This is achieved by analyzing the relationship between different descriptions of polarized Bessel beams obtained using different approaches. It is shown that a class of circularly symmetric Davis Bessel beams derived using the Hertz vector potentials possesses the same general functional dependence as the aplanatic Bessel beams generated using the angular spectrum representation (ASR). This result bridges the gap between different descriptions of Bessel beams and leads to a general description of circularly symmetric Bessel beams, such that the Davis Bessel beams and the aplanatic Bessel beams are merely the two simplest cases of an infinite number of possible circularly symmetric Bessel beams. Additionally, magnitude profiles of the electric and magnetic fields, the energy density and the Poynting vector are displayed for Bessel beams in both paraxial and nonparaxial cases. The results presented in this paper provide a fresh perspective on the description of Bessel beams and cast some insights into the light scattering and light-matter interactions problems in practice.

  3. LARYNGEAL MALIGNANCY: A RETROSPECTIVE DESCRIPTIVE ANALYSIS

    Directory of Open Access Journals (Sweden)

    Vinod Kumar

    2016-06-01

    Full Text Available BACKGROUND Laryngeal cancer is the second most common head and neck cancer in India. The onset, rate of progression and duration of symptoms are variable for supraglottic, glottic and subglottic cancer. Smoking and alcohol are also most important risk factors for laryngeal cancer. Data regarding cases of laryngeal cancer in relation to age, sex, symptoms and signs, aetiological factors with special reference to smoking and alcohol, histopathological types, tumour staging, treatment and outcomes are important to assess changing trends in laryngeal cancer treatment. MATERIALS AND METHODS This study is about retrospective descriptive analysis of diagnosed and treated cases of laryngeal cancer in the Department of ENT from 2005 to 2008. Total fifty patients with laryngeal malignancy were seen from May 2005 to May 2008 with average 1 year of follow-up. Data regarding cases of laryngeal cancer in relation to age, sex, symptoms and signs, aetiological factors with special reference to smoking and alcohol, histopathological types, tumour staging, treatment and outcomes were analysed using SPSS software. All patients who were diagnosed to have laryngeal cancer and treated were included in the study. RESULTS In this descriptive analysis, 62% patients are between 51-70 years. Most of the patients had been symptomatic for 3-5 months; 58% patients presented with voice change followed by other complaints like throat pain, foreign body sensation, otalgia, breathing difficulty. Voice change was distinctly the most common symptom regardless of tumour site. It was more prevalent in glottis cases, but it was also the leading symptom in supraglottic tumours. Glottis tumours were more often found at an early stage and patients with a supraglottic tumour presented more often with neck node metastasis. CONCLUSION Laryngeal malignancy is one of the head and neck malignancies, which are more common in males. Tobacco is an important risk factor in causation of the

  4. On the tomographic description of classical fields

    CERN Document Server

    Ibort, A; Man'ko, V I; Marmo, G; Simoni, A; Sudarshan, E C G; Ventriglia, F

    2012-01-01

    After a general description of the tomographic picture for classical systems, a tomographic description of free classical scalar fields is proposed both in a finite cavity and the continuum. The tomographic description is constructed in analogy with the classical tomographic picture of an ensemble of harmonic oscillators. The tomograms of a number of relevant states such as the canonical distribution, the classical counterpart of quantum coherent states and a new family of so called Gauss--Laguerre states, are discussed. Finally the Liouville equation for field states is described in the tomographic picture offering an alternative description of the dynamics of the system that can be extended naturally to other fields.

  5. Clinical presentation of cerebral aneurysms

    Energy Technology Data Exchange (ETDEWEB)

    Cianfoni, Alessandro [Neurocentro della Svizzera Italiana, Ospedale Civico di Lugano, via Tesserete, 46, 6900 Lugano (Switzerland); Pravatà, Emanuele, E-mail: emanuele.pravata@gmail.com [Neurocentro della Svizzera Italiana, Ospedale Civico di Lugano, via Tesserete, 46, 6900 Lugano (Switzerland); De Blasi, Roberto [Neurocentro della Svizzera Italiana, Ospedale Civico di Lugano, via Tesserete, 46, 6900 Lugano (Switzerland); Tschuor, Costa Silvia [Dipartimento di Radiologia, Ospedale Civico di Lugano, via Tesserete, 46, 6900 Lugano (Switzerland); Bonaldi, Giuseppe [U.O. Neuroradiologia, Ospedali Riuniti di Bergamo, Largo Barozzi, 1, 24128 Bergamo (Italy)

    2013-10-01

    Presentation of a cerebral aneurysm can be incidental, discovered at imaging obtained for unrelated causes, can occur in the occasion of imaging obtained for symptoms possibly or likely related to the presence of an unruptured aneurysm, or can occur with signs and symptoms at the time of aneurismal rupture. Most unruptured intracranial aneurysms are thought to be asymptomatic, or present with vague or non-specific symptoms like headache or dizziness. Isolated oculomotor nerve palsies, however, may typically indicate the presence of a posterior circulation aneurysm. Ruptured intracranial aneurysms are by far the most common cause of non-traumatic subarachnoid hemorrhage and represent a neurological emergency with potentially devastating consequences. Subarachnoid hemorrhage may be easily suspected in the presence of sudden and severe headache, vomiting, meningism signs, and/or altered mental status. However, failure to recognize milder and more ambiguous clinical pictures may result in a delayed or missed diagnosis. In this paper we will describe the clinical spectrum of unruptured and ruptured intracranial aneurysms by discussing both typical and uncommon clinical features emerging from the literature review. We will additionally provide the reader with descriptions of the underlying pathophysiologic mechanisms, and main diagnostic pitfalls.

  6. Workshop Presentations: Overviews

    Data.gov (United States)

    National Aeronautics and Space Administration — These slides were presented at the AePW, April 21-22, 2012. Additional presentations can be found on each of the associated analysis webpages. Separate pages contain...

  7. Marketing through Video Presentations.

    Science.gov (United States)

    Newhart, Donna

    1989-01-01

    Discusses the advantages of using video presentations as marketing tools. Includes information about video news releases, public service announcements, and sales/marketing presentations. Describes the three stages in creating a marketing video: preproduction planning; production; and postproduction. (JOW)

  8. Using Open Geographic Data to Generate Natural Language Descriptions for Hydrological Sensor Networks

    OpenAIRE

    Martin Molina; Javier Sanchez-Soriano; Oscar Corcho

    2015-01-01

    Providing descriptions of isolated sensors and sensor networks in natural language, understandable by the general public, is useful to help users find relevant sensors and analyze sensor data. In this paper, we discuss the feasibility of using geographic knowledge from public databases available on the Web (such as OpenStreetMap, Geonames, or DBpedia) to automatically construct such descriptions. We present a general method that uses such information to generate sensor descriptions in natural...

  9. Make Your Presentation Powerful

    Science.gov (United States)

    Palmer, Erik

    2015-01-01

    "I was planning on doing a lot of work today during your presentation, but I couldn't get anything done. I just had to pay attention!" The author received this unexpected feedback from a teacher at the end of a presentation he gave, and although he considered it a compliment, it made him reflect on the dire state of presentations in…

  10. Presenting Food Science Effectively

    Science.gov (United States)

    Winter, Carl K.

    2016-01-01

    While the need to present food science information effectively is viewed as a critical competency for food scientists by the Institute of Food Technologists, most food scientists may not receive adequate training in this area. Effective presentations combine both scientific content and delivery mechanisms that demonstrate presenter enthusiasm for…

  11. Rotating Poster Presentations

    Science.gov (United States)

    Lagares, Manuel; Reisenleutner, Sandra

    2017-01-01

    Oral presentations are a common practice in foreign language classes, often used to assess students' speaking skills. Usually, the presentations are delivered by students in front of the class, often with PowerPoint slides or Prezi as support. However, frequently the audience does not engage with the presentation and thus, the benefits of this…

  12. Description and key to larvae of Curculio spp. of eastern United States and Canada (coleoptera: Curculionidae)

    Science.gov (United States)

    Lester P. Gibson

    1985-01-01

    A general description of Curculio larvae is given. Ke y characters are presented to separate 15 of the 16 described species of eastern North America. A brief key for separating Curculio larvae from Conotrachelus and lepidopterous larvae is presented.

  13. Patterns and Prevalence of School Access, Transitions and Equity in South Africa: Secondary Analyses of BT20 Large-Scale Data Sources. CREATE Pathways to Access. Research Monograph No. 27

    Science.gov (United States)

    Fleisch, Brahm; Shindler, Jennifer

    2009-01-01

    This monograph looks at patterns and prevalence of initial school enrolment, late entry, attainment promotion, and repetition in urban South Africa. The paper pays special attention to the particular gender nature of the patterns of school participation. The study analyses data generated in the genuine representative cohort study, Birth-to-Twenty…

  14. Rune Frederiksen, Elizabeth R. Gebhard & Alexander Sokolicek (eds., The Architecture of the Ancient Greek Theatre, Monographs of the Danish Institute, Volume 17 (Aarhus: Aarhus University Press and The Danish Institute at Athens, 2015

    Directory of Open Access Journals (Sweden)

    William C. Miller

    2017-03-01

    Full Text Available A review of the book: Rune Frederiksen, Elizabeth R. Gebhard & Alexander Sokolicek (eds., The Architecture of the Ancient Greek Theatre, Monographs of the Danish Institute, Volume 17 (Aarhus: Aarhus University Press and The Danish Institute at Athens, 2015

  15. Unconventional Methods and Materials for Preparing Educational Administrators. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM State-of-the-Knowledge Series, Number Fifteen. UCEA Monograph Series, Number Two.

    Science.gov (United States)

    Wynn, Richard

    In this monograph, the author describes the variety of new and innovative instructional methods and materials being used to prepare educational administrators. Because the subject is new and the nomenclature surrounding it imprecise, the author defines his terms. An outline of the history of unconventional instructional methods and the rationale…

  16. Preparing Educational Leaders: A Review of Recent Literature. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM/ State-of-the-Knowledge Series, Number Fourteen. UCEA Monograph Series, Number One.

    Science.gov (United States)

    Farquhar, Robin H.; Piele, Philip K.

    In this monograph, the authors provide a general overview of recent literature on administrator preparation programs. Ten chapters parallel the major interrelated components of an administrator preparation program: Program content, program structure, recruitment and selection, instructional approaches, field-related experiences, student research,…

  17. Training-in-Common for Educational, Public, and Business Administrators. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM State-of-the-Knowledge Series, Number Seventeen. UCEA Monograph Series, Number Four.

    Science.gov (United States)

    Miklos, Erwin

    In this monograph, the author assesses the progress that has been made toward the development of in-common programs for preparing administrators to serve in a variety of institutional settings. After outlining the assumptions, rationales, and strategies behind attempts to institute interdisciplinary administrator training programs, the author…

  18. New Approaches to Recruitment and Selection of Educational Administrators. ERIC/CEM-UCEA Series on Administrator Preparation. ERIC/CEM State-of-the-Knowledge Series, Number Eighteen. UCEA Monograph Series, Number Five.

    Science.gov (United States)

    Stout, Robert T.

    In this monograph, the author claims there is a need for administrators who are responsive to legitimate demands for educational change. He reviews the shortcomings of contemporary American educational systems and traditional procedures for selecting and preparing administrators -- a group noted for its size and homogeneity. The author contends…

  19. 港口危险化学品项目安全设施设计专篇编制要点分析%Points analysis for compilation of safety facilities designed monographs in port hazardous chemicals project

    Institute of Scientific and Technical Information of China (English)

    韩刚; 龚庆文; 赵秀慧

    2014-01-01

    以天津浮式LNG接收终端项目(一期)码头工程为依托,从安全设施设计专篇的前期准备工作、编制内容及专篇审查各环节进行逐一论述,使设计人员对此类设计专篇的工作有一个全面系统的了解,并为今后危险化学品码头工程安全设施设计专篇的编制提供借鉴。%Taking Tianjin floating LNG receiving terminal project (Phase I) wharf engineering as the basis, we discussed the preparatory work, monographs content and monographs reviewing of safety facilities designed monographs to allow designers to have a comprehensive and systematic understanding of such designs, which can provide a reference for the future work of dan-gerous chemicals wharf engineering safety facilities designed monographs.

  20. Innovative presentations for dummies

    CERN Document Server

    Anthony, Ray

    2014-01-01

    Be the speaker they follow with breakthrough innovative presentations Innovative Presentations For Dummies is a practical guide to engaging your audience with superior, creative, and ultra-compelling presentations. Using clear language and a concise style, this book goes way beyond PowerPoint to enable you to reimagine, reinvent, and remake your presentations. Learn how to stimulate, capture, and hold your audience in the palm of your hand with sound, sight, and touch, and get up to speed on the latest presentation design methods that make you a speaker who gets audiences committed and acting