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Sample records for monocular deprivation md

  1. Recovery of neurofilament following early monocular deprivation

    Directory of Open Access Journals (Sweden)

    Timothy P O'Leary

    2012-04-01

    Full Text Available A brief period of monocular deprivation in early postnatal life can alter the structure of neurons within deprived-eye-receiving layers of the dorsal lateral geniculate nucleus. The modification of structure is accompanied by a marked reduction in labeling for neurofilament, a protein that composes the stable cytoskeleton and that supports neuron structure. This study examined the extent of neurofilament recovery in monocularly deprived cats that either had their deprived eye opened (binocular recovery, or had the deprivation reversed to the fellow eye (reverse occlusion. The degree to which recovery was dependent on visually-driven activity was examined by placing monocularly deprived animals in complete darkness (dark rearing. The loss of neurofilament and the reduction of soma size caused by monocular deprivation were both ameliorated equally following either binocular recovery or reverse occlusion for 8 days. Though monocularly deprived animals placed in complete darkness showed recovery of soma size, there was a generalized loss of neurofilament labeling that extended to originally non-deprived layers. Overall, these results indicate that recovery of soma size is achieved by removal of the competitive disadvantage of the deprived eye, and occurred even in the absence of visually-driven activity. Recovery of neurofilament occurred when the competitive disadvantage of the deprived eye was removed, but unlike the recovery of soma size, was dependent upon visually-driven activity. The role of neurofilament in providing stable neural structure raises the intriguing possibility that dark rearing, which reduced overall neurofilament levels, could be used to reset the deprived visual system so as to make it more ameliorable with treatment by experiential manipulations.

  2. Monocular Visual Deprivation Suppresses Excitability in Adult Human Visual Cortex

    DEFF Research Database (Denmark)

    Lou, Astrid Rosenstand; Madsen, Kristoffer Hougaard; Paulson, Olaf Bjarne

    2011-01-01

    The adult visual cortex maintains a substantial potential for plasticity in response to a change in visual input. For instance, transcranial magnetic stimulation (TMS) studies have shown that binocular deprivation (BD) increases the cortical excitability for inducing phosphenes with TMS. Here, we...... employed TMS to trace plastic changes in adult visual cortex before, during, and after 48 h of monocular deprivation (MD) of the right dominant eye. In healthy adult volunteers, MD-induced changes in visual cortex excitability were probed with paired-pulse TMS applied to the left and right occipital cortex....... Stimulus–response curves were constructed by recording the intensity of the reported phosphenes evoked in the contralateral visual field at range of TMS intensities. Phosphene measurements revealed that MD produced a rapid and robust decrease in cortical excitability relative to a control condition without...

  3. Effect of monocular deprivation on rabbit neural retinal cell densities

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    Philip Maseghe Mwachaka

    2015-01-01

    Conclusion: In this rabbit model, monocular deprivation resulted in activity-dependent changes in cell densities of the neural retina in favour of the non-deprived eye along with reduced cell densities in the deprived eye.

  4. Short-Term Monocular Deprivation Enhances Physiological Pupillary Oscillations.

    Science.gov (United States)

    Binda, Paola; Lunghi, Claudia

    2017-01-01

    Short-term monocular deprivation alters visual perception in adult humans, increasing the dominance of the deprived eye, for example, as measured with binocular rivalry. This form of plasticity may depend upon the inhibition/excitation balance in the visual cortex. Recent work suggests that cortical excitability is reliably tracked by dilations and constrictions of the pupils of the eyes. Here, we ask whether monocular deprivation produces a systematic change of pupil behavior, as measured at rest, that is independent of the change of visual perception. During periods of minimal sensory stimulation (in the dark) and task requirements (minimizing body and gaze movements), slow pupil oscillations, "hippus," spontaneously appear. We find that hippus amplitude increases after monocular deprivation, with larger hippus changes in participants showing larger ocular dominance changes (measured by binocular rivalry). This tight correlation suggests that a single latent variable explains both the change of ocular dominance and hippus. We speculate that the neurotransmitter norepinephrine may be implicated in this phenomenon, given its important role in both plasticity and pupil control. On the practical side, our results indicate that measuring the pupil hippus (a simple and short procedure) provides a sensitive index of the change of ocular dominance induced by short-term monocular deprivation, hence a proxy for plasticity.

  5. Short-Term Monocular Deprivation Enhances Physiological Pupillary Oscillations

    Directory of Open Access Journals (Sweden)

    Paola Binda

    2017-01-01

    Full Text Available Short-term monocular deprivation alters visual perception in adult humans, increasing the dominance of the deprived eye, for example, as measured with binocular rivalry. This form of plasticity may depend upon the inhibition/excitation balance in the visual cortex. Recent work suggests that cortical excitability is reliably tracked by dilations and constrictions of the pupils of the eyes. Here, we ask whether monocular deprivation produces a systematic change of pupil behavior, as measured at rest, that is independent of the change of visual perception. During periods of minimal sensory stimulation (in the dark and task requirements (minimizing body and gaze movements, slow pupil oscillations, “hippus,” spontaneously appear. We find that hippus amplitude increases after monocular deprivation, with larger hippus changes in participants showing larger ocular dominance changes (measured by binocular rivalry. This tight correlation suggests that a single latent variable explains both the change of ocular dominance and hippus. We speculate that the neurotransmitter norepinephrine may be implicated in this phenomenon, given its important role in both plasticity and pupil control. On the practical side, our results indicate that measuring the pupil hippus (a simple and short procedure provides a sensitive index of the change of ocular dominance induced by short-term monocular deprivation, hence a proxy for plasticity.

  6. Decrease in monocular sleep after sleep deprivation in the domestic chicken

    NARCIS (Netherlands)

    Boerema, AS; Riedstra, B; Strijkstra, AM

    2003-01-01

    We investigated the trade-off between sleep need and alertness, by challenging chickens to modify their monocular sleep. We sleep deprived domestic chickens (Gallus domesticus) to increase their sleep need. We found that in response to sleep deprivation the fraction of monocular sleep within sleep

  7. Decrease in monocular sleep after sleep deprivation in the domestic chicken

    NARCIS (Netherlands)

    Boerema, AS; Riedstra, B; Strijkstra, AM

    2003-01-01

    We investigated the trade-off between sleep need and alertness, by challenging chickens to modify their monocular sleep. We sleep deprived domestic chickens (Gallus domesticus) to increase their sleep need. We found that in response to sleep deprivation the fraction of monocular sleep within sleep d

  8. Reactivation of thalamocortical plasticity by dark exposure during recovery from chronic monocular deprivation

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    Montey, Karen L.; Quinlan, Elizabeth M.

    2015-01-01

    Chronic monocular deprivation induces severe amblyopia that is resistant to spontaneous reversal in adulthood. However, dark exposure initiated in adulthood reactivates synaptic plasticity in the visual cortex and promotes recovery from chronic monocular deprivation. Here we show that chronic monocular deprivation significantly decreases the strength of feedforward excitation and significantly decreases the density of dendritic spines throughout the deprived binocular visual cortex. Dark exposure followed by reverse deprivation significantly enhances the strength of thalamocortical synaptic transmission and the density of dendritic spines on principle neurons throughout the depth of the visual cortex. Thus dark exposure reactivates widespread synaptic plasticity in the adult visual cortex, including at thalamocortical synapses, during the recovery from chronic monocular deprivation. PMID:21587234

  9. Monocular deprivation of Fourier phase information boosts the deprived eye's dominance during interocular competition but not interocular phase combination.

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    Bai, Jianying; Dong, Xue; He, Sheng; Bao, Min

    2017-06-03

    Ocular dominance has been extensively studied, often with the goal to understand neuroplasticity, which is a key characteristic within the critical period. Recent work on monocular deprivation, however, demonstrates residual neuroplasticity in the adult visual cortex. After deprivation of patterned inputs by monocular patching, the patched eye becomes more dominant. Since patching blocks both the Fourier amplitude and phase information of the input image, it remains unclear whether deprivation of the Fourier phase information alone is able to reshape eye dominance. Here, for the first time, we show that removing of the phase regularity without changing the amplitude spectra of the input image induced a shift of eye dominance toward the deprived eye, but only if the eye dominance was measured with a binocular rivalry task rather than an interocular phase combination task. These different results indicate that the two measurements are supported by different mechanisms. Phase integration requires the fusion of monocular images. The fused percept highly relies on the weights of the phase-sensitive monocular neurons that respond to the two monocular images. However, binocular rivalry reflects the result of direct interocular competition that strongly weights the contour information transmitted along each monocular pathway. Monocular phase deprivation may not change the weights in the integration (fusion) mechanism much, but alters the balance in the rivalry (competition) mechanism. Our work suggests that ocular dominance plasticity may occur at different stages of visual processing, and that homeostatic compensation also occurs for the lack of phase regularity in natural scenes. Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

  10. Rapid recovery from the effects of early monocular deprivation is enabled by temporary inactivation of the retinas

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    Fong, Ming-fai; Mitchell, Donald E.; Duffy, Kevin R.; Bear, Mark F.

    2016-01-01

    A half-century of research on the consequences of monocular deprivation (MD) in animals has revealed a great deal about the pathophysiology of amblyopia. MD initiates synaptic changes in the visual cortex that reduce acuity and binocular vision by causing neurons to lose responsiveness to the deprived eye. However, much less is known about how deprivation-induced synaptic modifications can be reversed to restore normal visual function. One theoretically motivated hypothesis is that a period of inactivity can reduce the threshold for synaptic potentiation such that subsequent visual experience promotes synaptic strengthening and increased responsiveness in the visual cortex. Here we have reduced this idea to practice in two species. In young mice, we show that the otherwise stable loss of cortical responsiveness caused by MD is reversed when binocular visual experience follows temporary anesthetic inactivation of the retinas. In 3-mo-old kittens, we show that a severe impairment of visual acuity is also fully reversed by binocular experience following treatment and, further, that prolonged retinal inactivation alone can erase anatomical consequences of MD. We conclude that temporary retinal inactivation represents a highly efficacious means to promote recovery of function. PMID:27856748

  11. Layer- and cell-type-specific subthreshold and suprathreshold effects of long-term monocular deprivation in rat visual cortex.

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    Medini, Paolo

    2011-11-23

    Connectivity and dendritic properties are determinants of plasticity that are layer and cell-type specific in the neocortex. However, the impact of experience-dependent plasticity at the level of synaptic inputs and spike outputs remains unclear along vertical cortical microcircuits. Here I compared subthreshold and suprathreshold sensitivity to prolonged monocular deprivation (MD) in rat binocular visual cortex in layer 4 and layer 2/3 pyramids (4Ps and 2/3Ps) and in thick-tufted and nontufted layer 5 pyramids (5TPs and 5NPs), which innervate different extracortical targets. In normal rats, 5TPs and 2/3Ps are the most binocular in terms of synaptic inputs, and 5NPs are the least. Spike responses of all 5TPs were highly binocular, whereas those of 2/3Ps were dominated by either the contralateral or ipsilateral eye. MD dramatically shifted the ocular preference of 2/3Ps and 4Ps, mostly by depressing deprived-eye inputs. Plasticity was profoundly different in layer 5. The subthreshold ocular preference shift was sevenfold smaller in 5TPs because of smaller depression of deprived inputs combined with a generalized loss of responsiveness, and was undetectable in 5NPs. Despite their modest ocular dominance change, spike responses of 5TPs consistently lost their typically high binocularity during MD. The comparison of MD effects on 2/3Ps and 5TPs, the main affected output cells of vertical microcircuits, indicated that subthreshold plasticity is not uniquely determined by the initial degree of input binocularity. The data raise the question of whether 5TPs are driven solely by 2/3Ps during MD. The different suprathreshold plasticity of the two cell populations could underlie distinct functional deficits in amblyopia.

  12. Reduced responsiveness to long-term monocular deprivation of parvalbumin neurons assessed by c-Fos staining in rat visual cortex.

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    Marco Mainardi

    Full Text Available BACKGROUND: It is generally assumed that visual cortical cells homogeneously shift their ocular dominance (OD in response to monocular deprivation (MD, however little experimental evidence directly supports this notion. By using immunohistochemistry for the activity-dependent markers c-Fos and Arc, coupled with staining for markers of inhibitory cortical sub-populations, we studied whether long-term MD initiated at P21 differentially affects visual response of inhibitory neurons in rat binocular primary visual cortex. METHODOLOGY/PRINCIPAL FINDINGS: The inhibitory markers GAD67, parvalbumin (PV, calbindin (CB and calretinin (CR were used. Visually activated Arc did not colocalize with PV and was discarded from further studies. MD decreased visually induced c-Fos activation in GAD67 and CR positive neurons. The CB population responded to MD with a decrease of CB expression, while PV cells did not show any effect of MD on c-Fos expression. The persistence of c-Fos expression induced by deprived eye stimulation in PV cells is not likely to be due to a particularly low threshold for activity-dependent c-Fos induction. Indeed, c-Fos induction by increasing concentrations of the GABAA antagonist picrotoxin in visual cortical slices was similar between PV cells and the other cortical neurons. CONCLUSION: These data indicate that PV cells are particularly refractory to MD, suggesting that different cortical subpopulation may show different response to MD.

  13. Short-term monocular deprivation strengthens the patched eye's contribution to binocular combination.

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    Zhou, Jiawei; Clavagnier, Simon; Hess, Robert F

    2013-04-18

    Binocularity is a fundamental property of primate vision. Ocular dominance describes the perceptual weight given to the inputs from the two eyes in their binocular combination. There is a distribution of sensory dominance within the normal binocular population with most subjects having balanced inputs while some are dominated by the left eye and some by the right eye. Using short-term monocular deprivation, the sensory dominance can be modulated as, under these conditions, the patched eye's contribution is strengthened. We address two questions: Is this strengthening a general effect such that it is seen for different types of sensory processing? And is the strengthening specific to pattern deprivation, or does it also occur for light deprivation? Our results show that the strengthening effect is a general finding involving a number of sensory functions, and it occurs as a result of both pattern and light deprivation.

  14. Relationship between monocularly deprivation and amblyopia rats and visual system development

    Institute of Scientific and Technical Information of China (English)

    Yu Ma

    2014-01-01

    Objective:To explore the changes of lateral geniculate body and visual cortex in monocular strabismus and form deprived amblyopic rat, and visual development plastic stage and visual plasticity in adult rats.Methods:A total of60SD rats ages13 d were randomly divided intoA, B,C three groups with20 in each group, groupA was set as the normal control group without any processing, groupB was strabismus amblyopic group, using the unilateral extraocular rectus resection to establish the strabismus amblyopia model, groupC was monocular form deprivation amblyopia group using unilateral eyelid edge resection+ lid suture.At visual developmental early phase(P25), meta phase(P35), late phase(P45) and adult phase(P120), the lateral geniculate body and visual cortex area17 of five rats in each group were exacted forC-fosImmunocytochemistry. Neuron morphological changes in lateral geniculate body and visual cortex was observed, the positive neurons differences ofC-fos expression induced by light stimulation was measured in each group, and the condition of radiation development ofP120 amblyopic adult rats was observed.Results:In groupsB andC,C-fos positive cells were significantly lower thanthe control group atP25(P0.05),C-fos protein positive cells level of groupB was significantly lower than that of groupA(P<0.05).The binoculusC-fos protein positive cells level of groupsB andC were significantly higher than that of control group atP35,P45 andP120 with statistically significant differences(P<0.05).Conclusions:The increasing ofC-fos expression in geniculate body and visual cortex neurons of adult amblyopia suggests the visual cortex neurons exist a certain degree of visual plasticity.

  15. Brief monocular deprivation as an assay of short-term visual sensory plasticity in schizophrenia – the binocular effect.

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    John J Foxe

    2013-12-01

    Full Text Available Background: Visual sensory processing deficits are consistently observed in schizophrenia, with clear amplitude reduction of the visual evoked potential (VEP during the initial 50-150 milliseconds of processing. Similar deficits are seen in unaffected first-degree relatives and drug-naïve first-episode patients, pointing to these deficits as potential endophenotypic markers. Schizophrenia is also associated with deficits in neural plasticity, implicating dysfunction of both glutamatergic and gabaergic systems. Here, we sought to understand the intersection of these two domains, asking whether short-term plasticity during early visual processing is specifically affected in schizophrenia. Methods: Brief periods of monocular deprivation induce relatively rapid changes in the amplitude of the early VEP – i.e. short-term plasticity. Twenty patients and twenty non-psychiatric controls participated. VEPs were recorded during binocular viewing, and were compared to the sum of VEP responses during brief monocular viewing periods (i.e. Left-eye + Right-eye viewing. Results: Under monocular conditions, neurotypical controls exhibited an effect that patients failed to demonstrate. That is, the amplitude of the summed monocular VEPs was robustly greater than the amplitude elicited binocularly during the initial sensory processing period. In patients, this binocular effect was absent. Limitations: Patients were all medicated. Ideally, this study would also include first-episode unmedicated patients.Conclusions: These results suggest that short-term compensatory mechanisms that allow healthy individuals to generate robust VEPs in the context of monocular deprivation are not effectively activated in patients with schizophrenia. This simple assay may provide a useful biomarker of short-term plasticity in the psychotic disorders and a target endophenotype for therapeutic interventions.

  16. TrkA activation in the rat visual cortex by antirat trkA IgG prevents the effect of monocular deprivation.

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    Pizzorusso, T; Berardi, N; Rossi, F M; Viegi, A; Venstrom, K; Reichardt, L F; Maffei, L

    1999-01-01

    It has been recently shown that intraventricular injections of nerve growth factor (NGF) prevent the effects of monocular deprivation in the rat. We have tested the localization and the molecular nature of the NGF receptor(s) responsible for this effect by activating cortical trkA receptors in monocularly deprived rats by cortical infusion of a specific agonist of NGF on trkA, the bivalent antirat trkA IgG (RTA-IgG). TrkA protein was detected by immunoblot in the rat visual cortex during the critical period. Rats were monocularly deprived for 1 week (P21-28) and RTA-IgG or control rabbit IgG were delivered by osmotic minipumps. The effects of monocular deprivation on the ocular dominance of visual cortical neurons were assessed by extracellular single cell recordings. We found that the shift towards the ipsilateral, non-deprived eye was largely prevented by RTA-IgG. Infusion of RTA-IgG combined with antibody that blocks p75NTR (REX), slightly reduced RTA-IgG effectiveness in preventing monocular deprivation effects. These results suggest that NGF action in visual cortical plasticity is mediated by cortical TrkA receptors with p75NTR exerting a facilitatory role.

  17. Monocular deprivation delays the dynamic changes of phosphorylated synapsin Ia/b at site-1 in contralateral visual cortex of juvenile mice.

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    Fu, Tao; Su, Qing; Xi, Ping; Han, Song; Li, Junfa

    2015-03-01

    Synapsins as a family of presynaptic terminal phosphoprotein participates in neuronal development, but their role in the synaptic plasticity of visual cortex is unclear. In this study, the impact of monocular deprivation (MD) on dynamic changes of isoform-specific protein expression and site 1 phosphorylation of synapsins in visual cortex of the postnatal mice were observed by using the technique of Western blot analysis. The results showed that the total (T-) protein levels of synapsins including the isoform of Ia/b, IIa/b and IIIa were about 21-26% of adult level in visual cortex of mice at postnatal 7 days (P7), and then the T-synapsin Ia/b and IIb could quickly reach adult level at P35. However, the T-synapsin IIa and IIIa increased more slowly (71-74% at P35), and then kept increasing in the visual cortex of mice at P60. Unlike to the changes of T-synapsins, the level of phosphorylated (P-) synapsin Ia/b (not IIa/b and IIIa) at site 1 increased with development to the highest level at P21, and then decreased rapidly to a low level in visual cortex of mice at P35-60. In addition, we found that the levels of P-synapsin Ia/b increased significantly in left visual cortex of P28 and P35 (not P21 and P42) mice with 1-week MD of right eye; and no significant changes of T-synapsins were observed in both left and right sides of visual cortex in P21-42 mice with MD treatment. These results suggested that the isoform-specific protein expression and site-1 phosphorylation of synapsins might play a different role in the synaptic plasticity of visual cortex, and MD delays the dynamic changes of phosphorylated synapsin Ia/b at site-1 in contralateral visual cortex of juvenile mice.

  18. Effects of brief daily periods of unrestricted vision during early monocular form deprivation on development of visual area 2.

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    Zhang, Bin; Tao, Xiaofeng; Wensveen, Janice M; Harwerth, Ronald S; Smith, Earl L; Chino, Yuzo M

    2011-09-14

    Providing brief daily periods of unrestricted vision during early monocular form deprivation reduces the depth of amblyopia. To gain insights into the neural basis of the beneficial effects of this treatment, the binocular and monocular response properties of neurons were quantitatively analyzed in visual area 2 (V2) of form-deprived macaque monkeys. Beginning at 3 weeks of age, infant monkeys were deprived of clear vision in one eye for 12 hours every day until 21 weeks of age. They received daily periods of unrestricted vision for 0, 1, 2, or 4 hours during the form-deprivation period. After behavioral testing to measure the depth of the resulting amblyopia, microelectrode-recording experiments were conducted in V2. The ocular dominance imbalance away from the affected eye was reduced in the experimental monkeys and was generally proportional to the reduction in the depth of amblyopia in individual monkeys. There were no interocular differences in the spatial properties of V2 neurons in any subject group. However, the binocular disparity sensitivity of V2 neurons was significantly higher and binocular suppression was lower in monkeys that had unrestricted vision. The decrease in ocular dominance imbalance in V2 was the neuronal change most closely associated with the observed reduction in the depth of amblyopia. The results suggest that the degree to which extrastriate neurons can maintain functional connections with the deprived eye (i.e., reducing undersampling for the affected eye) is the most significant factor associated with the beneficial effects of brief periods of unrestricted vision.

  19. TrkA activation in the rat visual cortex by antirat trkA IgG prevents the effect of monocular deprivation

    OpenAIRE

    Pizzorusso, Tommaso; Berardi, Nicoletta; Rossi, Francesco M.; Viegi, Alessandro; Venstrom, Kristine; Reichardt, Louis F.; Maffei, Lamberto

    1999-01-01

    It has been recently shown that intraventricular injections of nerve growth factor (NGF) prevent the effects of monocular deprivation in the rat. We have tested the localization and the molecular nature of the NGF receptor(s) responsible for this effect by activating cortical trkA receptors in monocularly deprived rats by cortical infusion of a specific agonist of NGF on trkA, the bivalent antirat trkA IgG (RTA-IgG). TrkA protein was detected by immunoblot in the rat visual cortex during the ...

  20. Adult Visual Experience Promotes Recovery of Primary Visual Cortex from Long-Term Monocular Deprivation

    Science.gov (United States)

    Fischer, Quentin S.; Aleem, Salman; Zhou, Hongyi; Pham, Tony A.

    2007-01-01

    Prolonged visual deprivation from early childhood to maturity is believed to cause permanent visual impairment. However, there have been case reports of substantial improvement of binocular vision in human adults following lifelong visual impairment or deprivation. These observations, together with recent findings of adult ocular dominance…

  1. Adult Visual Experience Promotes Recovery of Primary Visual Cortex from Long-Term Monocular Deprivation

    Science.gov (United States)

    Fischer, Quentin S.; Aleem, Salman; Zhou, Hongyi; Pham, Tony A.

    2007-01-01

    Prolonged visual deprivation from early childhood to maturity is believed to cause permanent visual impairment. However, there have been case reports of substantial improvement of binocular vision in human adults following lifelong visual impairment or deprivation. These observations, together with recent findings of adult ocular dominance…

  2. PSD-95在正常发育和单眼剥夺大鼠视皮层的表达%Expression of PSD-95 in visual cortex of normal and monocular deprived rats

    Institute of Scientific and Technical Information of China (English)

    安喜艳; 赵堪兴

    2011-01-01

    目的 研究突触后致密物(post-synaptic density,PSD)-95在正常发育以及单眼视觉剥夺性大鼠视皮层中的蛋白动态表达情况,以期在突触水平为视觉发育可塑性提供分子基础.方法 健康生后14 d Wistar大鼠35只,随机分成正常组及单眼剥夺组,单眼剥夺组在生后14 d行单眼缝合术制备单眼剥夺模型.动物在同等环境下喂养,分别于生后14 d、21 d、28 d、45 d麻醉、灌注、固定、开颅、冠状切取后部脑组织(单眼剥夺组取剥夺眼对侧脑组织),进行常规HE和免疫组织化学方法染色.结果 HE染色中正常发育大鼠视皮层的神经元分布呈层状,且各层神经元排列整齐;单眼剥夺组大鼠视皮层未见明显异常.正常发育组PSD-95蛋白的表达随年龄呈发育性变化,生后21 d有明显升高(12.47±2.06),28 d(10.54±1.72)、45 d(11.65±1.55)持续在较高水平.PSD-95表达产物在单眼剥夺组较正常组明显减少.生后21 d(4.94±0.57)、28 d(5.20±0.47)、45 d(4.87±0.72)与正常组相比均下降(均为P<0.05).结论 PSD-95可能参与视觉发育敏感期视皮层神经元可塑性的调节.%Objective To study the dynamic expression of post-synaptic density (PSD)-95 in the visual cortex of normal and monocular deprived rats and provide the molecular mechanism of the visual plasticity at the level of synapse. Methods Thirty-five healthy Wistar rats with 14 days old were randomly divided into normal group (N) and monocular deprivation group (MD). The eyelids of MD groups were sutured at postnatal 14 days to obtain animal model. Rats were housed in alike environment, at postnatal 14 days,21 days,28 days,45 days the posterior brain coronally (get the brain opposite to deprived eye in the rats of MD) were cut after anesthesia, perfusion, fixation and opening cranium,the routine HE staining and immunohistochemistry staining were carried out. Results HE staining results showed the neurons of visual cortex in normal rats

  3. Pattern adaptation of relay cells in the lateral geniculate nucleus of binocular and monocular vision-deprived cats%双眼和单眼视觉剥夺猫外膝体细胞的图形适应

    Institute of Scientific and Technical Information of China (English)

    王伟; 寿天德

    2000-01-01

    为测定丘脑外膝体细胞的图形适应是否依赖于早期视觉经验, 在细胞外记录了双眼和单眼缝合的猫外膝体中继细胞对长时间运动光栅刺激的反应. 在双眼剥夺猫,占68%的记录到的细胞在30 s内反应下降到稳定值,其平均反应值下降33%,适应程度较正常猫显著.在单眼剥夺猫,记录到的剥夺眼驱动的和非剥夺眼驱动的细胞中,分别有占53%和44%的细胞显示图形适应, 两者差别不大.研究表明, 早期视剥夺能增强或保持图形适应, 提示图形适应是外膝体细胞常见的固有性质,可能主要由遗传因素所决定.%To test whether the pattern adaptation in thalamus is dependent upon postnatal visual experience during early life, the responses of relay cells to prolonged drifting grating stimulation were recorded extracellularly from the dorsal lateral geniculate nucleus (dLGN) of cats reared with binocular and monocular lid suture. In binocular vision-deprived cats, 68% of cells recorded showed significant adaptation to prolonged grating stimuli within 30 s, with a mean response decrease of 33%, and then stabilized gradually. This adaptation was stronger than that of relay cells in normal cats. In monocular vision-deprived cats, 53% of the cells driven by the deprived eye showed similar adaptation as did 44% of the cells driven by the non-deprived eye. These results indicate that pattern adaptation could be maintained or even enhanced after visual deprivation in early life. It is suggested that pattern adaptation is a general and intrinsic property of the dLGN cells, which may be mainly determined by genetic factors.

  4. Monocular transparency generates quantitative depth.

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    Howard, Ian P; Duke, Philip A

    2003-11-01

    Monocular zones adjacent to depth steps can create an impression of depth in the absence of binocular disparity. However, the magnitude of depth is not specified. We designed a stereogram that provides information about depth magnitude but which has no disparity. The effect depends on transparency rather than occlusion. For most subjects, depth magnitude produced by monocular transparency was similar to that created by a disparity-defined depth probe. Addition of disparity to monocular transparency did not improve the accuracy of depth settings. The magnitude of depth created by monocular occlusion fell short of that created by monocular transparency.

  5. Expression of mGluR1 at primary visual cortex of monocular deprivation amblyopia rat and the observing of ultrastructure%代谢性谷氨酸受体1在单眼形觉剥夺弱视大鼠视皮质17区的表达及超微结构观察

    Institute of Scientific and Technical Information of China (English)

    王宗青; 刘向玲; 穆雅林; 刘爱琴; 李晓鹏

    2008-01-01

    Objective To explore the regulation of expression of mGluR1 and the changes of neuron ultrastructure at primary visual cortex of monocular deprivation amblyopia rat within cortical period.Methods Taking randomized concurrent controlled trail.Establishing the model of monocular deprivation amblyopia rat.After proving the model successful by PVEP,all of the rats were randomly divided into three groups:normal visual cortex,experimental visual cortex and experimental opposite visual cortex.Immunocytochemical technology,electron microscope,photography microscope,computer image analysis,SPSS 11.5 and ANOV were used to get the resuhs.Results Compared with the layer Ⅳ of normal visual cortex and experimental opposite visual cortex,the area of immunopositive neurons in layer Ⅳ of experimental visual cortex are deficiency.there is significant difference between them(P<0.01).There are no significant differences between the other four corresponding layers(P>0.05).Morphological abnormals were found in layer Ⅳ of experimental visual cortex by observing of ultrastructure.Conclusion The expression of mGluR1 in layer Ⅳ of primary visual cortex of monocular deprivation amblyopia is reduced.There are morphological abnormals happened in layer Ⅳ of primary visual cortex of monocular derivation amblyopia.Reduced afference of nerve pulse because of monocular deprivation leads to the expression difficiency of mGluR1 in layer Ⅳ of the primary visual cortex,then synaptic plasticity happened,then neurons atrophy occurred may be one of the etiopathogenesis of amblyopia.%目的 探讨视觉形成关键期内单眼形觉剥夺弱视大鼠初级视皮质17区中代谢性谷氨酸受体1(mGluR1)的表达规律及神经元超微结构变化,为临床上揭示弱视的病理机制及防治提供依据.方法 随机对照同期动物实验.方法是建立大鼠单眼形觉剥夺弱视模型,经图形视觉诱发电位检测证实造模成功后,与正常对照组大鼠一起灌注

  6. Dendritic BDNF synthesis is required for late-phase spine maturation and recovery of cortical responses following sensory deprivation.

    Science.gov (United States)

    Kaneko, Megumi; Xie, Yuxiang; An, Juan Ji; Stryker, Michael P; Xu, Baoji

    2012-04-04

    Sensory experience in early postnatal life shapes neuronal connections in the brain. Here we report that the local synthesis of brain-derived neurotrophic factor (BDNF) in dendrites plays an important role in this process. We found that dendritic spines of layer 2/3 pyramidal neurons of the visual cortex in mutant mice lacking dendritic Bdnf mRNA and thus local BDNF synthesis were normal at 3 weeks of age, but thinner, longer, and more closely spaced (morphological features of immaturity) at 4 months of age than in wild-type (WT) littermates. Layer 2/3 of the visual cortex in these mutant animals also had fewer GABAergic presynaptic terminals at both ages. The overall size and shape of dendritic arbors were, however, similar in mutant and WT mice at both ages. By using optical imaging of intrinsic signals and single-unit recordings, we found that mutant animals failed to recover cortical responsiveness following monocular deprivation (MD) during the critical period, although they displayed normally the competitive loss of responsiveness to an eye briefly deprived of vision. Furthermore, MD still induced a loss of responsiveness to the closed eye in adult mutant mice, but not in adult WT mice. These results indicate that dendritic BDNF synthesis is required for spine pruning, late-phase spine maturation, and recovery of cortical responsiveness following sensory deprivation. They also suggest that maturation of dendritic spines is required for the maintenance of cortical responsiveness following sensory deprivation in adulthood.

  7. Monocular visual ranging

    Science.gov (United States)

    Witus, Gary; Hunt, Shawn

    2008-04-01

    The vision system of a mobile robot for checkpoint and perimeter security inspection performs multiple functions: providing surveillance video, providing high resolution still images, and providing video for semi-autonomous visual navigation. Mid-priced commercial digital cameras support the primary inspection functions. Semi-autonomous visual navigation is a tertiary function whose purpose is to reduce the burden of teleoperation and free the security personnel for their primary functions. Approaches to robot visual navigation require some form of depth perception for speed control to prevent the robot from colliding with objects. In this paper present the initial results of an exploration of the capabilities and limitations of using a single monocular commercial digital camera for depth perception. Our approach combines complementary methods in alternating stationary and moving behaviors. When the platform is stationary, it computes a range image from differential blur in the image stack collected at multiple focus settings. When the robot is moving, it extracts an estimate of range from the camera auto-focus function, and combines this with an estimate derived from angular expansion of a constellation of visual tracking points.

  8. Progress in the study of the mechanism of visual cortical excitability and inhibition of balance in the visual cortex of monocular deprivation%单眼形觉剥夺触发视皮层兴奋与抑制平衡突触缩放调节机制的研究进展

    Institute of Scientific and Technical Information of China (English)

    宋德胜; 郭雅图; 陈霞

    2016-01-01

    突触缩放是稳态可塑性研究中最常用的形式,神经系统活动水平全局性的降低(如单眼形觉剥夺)可触发突触缩放机制。稳态可塑性对于维持神经元活动在正常范围内波动是必不可少的,它可以调控由于突触强度增强或减弱引起的过高或过低的神经网络活动水平。大脑皮层的兴奋性与抑制性平衡是维持正常脑功能的前提,而失衡则会诱发癫痫、帕金森及抑郁症等多种神经疾病。抑制性突触的可塑性,在兴奋性与抑制性平衡中扮演着关键角色。业内既往的研究,多数集中在新皮层和海马区的突触缩放稳态的可塑性方面,而对于视皮层区域的研究报导尚少。本文就单眼形觉剥夺触发的视皮层兴奋与抑制平衡稳态突触缩放调节机制的研究进展进行综述。%Synaptic scaling is the most commonly used form in the study of homeostasis , and the reduction in the level of activity of the nervous system ( monocular deprivation ) triggers the mechanism of synaptic scaling .Steady state plasticity is essential for maintaining neuronal activity in the normal range , and it can be regulated by the high or low level of neural network activity caused by the increase or decrease in synaptic strength .The excitatory and inhibitory balance of the cerebral cortex is the premise to maintain the normal function of the brain , and its imbalance will induce epilepsy , Parkinson, depression and other neurological disorders .Inhibitory synaptic plasticity plays a key role in the balance of excitatory and inhibitory properties .Study on the past , the plasticity of synaptic zoom steady state most concentrated in the neocortex and hippocampus , and to study the visual cortex area is less reported .This paper is mainly concerned with the monocular sleep deprivation triggers the progress in the study on the mechanism of regulation of visual cortex balance of excitatory and inhibitory of

  9. DEPRIVATION AND STRABISMIC AMBLYOPIA: ABNORMALITIES IN GENICULOCORTICAL VISUAL PATHWAYS

    Directory of Open Access Journals (Sweden)

    S. V. Alekseenko

    2015-01-01

    Full Text Available Background: There are inconsistent data on the changes of functional performance in subcortical structures of visual system caused by early binocular vision impairment. Aim: To study neuronal functional activity of the dorsal lateral geniculate nucleus (LGNd in monocularly deprived cats and strabismic cats. Materials and methods: 4 cats with monocular convergent strabismus, 7 cats with monocular divergent strabismus, 3 monocularly deprived cats and 4 intact cats were studied. Histochemical method was used to detect cytochrome oxidase – the mitochondrial enzyme of respiratory chain correlating with neuronal functional activity. Optical density in ocular-specific layers A and A1 was measured on the images of stained LGNd sections, and the contrast was calculated. Results: Relative reduction of functional activity in the layers innervated from deprived and squinted eyes was demonstrated in LGNd bilaterally. In strabismic animals, the changes were observed only in the projection of the central part of the visual field, whereas in monocularly deprived animals the changes were in the projection of the whole visual field. Conclusion: These findings indicate differences between the mechanisms determining the development of strabismic and deprivation amblyopia. Thus, in amblyopia, preservation of peripheral stereoscopic vision is possible.

  10. Injection MD

    CERN Document Server

    Bartmann, W; Bracco, C; Drosdal, L; Gianfelice, E; Goddard, B; Kain, V; Papaphilippou, Y; Vanbavinckhove, G

    2012-01-01

    This note summarizes the results obtained at injection during the 2nd MD block and the floating MD block in July. Highlights are presented for injection in the LHC with the Q20 SPS optics, influence of the supercycle and injection with 25 ns bunch spacing. Beams were successfully injected into the LHC using the Q20 optics [1, 3]. Small corrections were needed to steer the beam in the transfer lines. Dispersion measurements were conducted for both beams. The horizontal normalized dispersion in TI2 was a factor 2 smaller for Q20 with respect to Q26, for TI8 on the other hand the opposite was observed. The results for injection loss dependency on super cycle composition show only a small increase in losses for beam 2. The losses observed must therefore mainly come from other sources such as shot-by-shot stability or quality of scraping. For the injection with 25 ns bunch spacing bunches were injected for both beams. For B1 up to the maximum of 288 bunches. For B2 on the other only up to 144 bunches were injected...

  11. Validation of Data Association for Monocular SLAM

    Directory of Open Access Journals (Sweden)

    Edmundo Guerra

    2013-01-01

    Full Text Available Simultaneous Mapping and Localization (SLAM is a multidisciplinary problem with ramifications within several fields. One of the key aspects for its popularity and success is the data fusion produced by SLAM techniques, providing strong and robust sensory systems even with simple devices, such as webcams in Monocular SLAM. This work studies a novel batch validation algorithm, the highest order hypothesis compatibility test (HOHCT, against one of the most popular approaches, the JCCB. The HOHCT approach has been developed as a way to improve performance of the delayed inverse-depth initialization monocular SLAM, a previously developed monocular SLAM algorithm based on parallax estimation. Both HOHCT and JCCB are extensively tested and compared within a delayed inverse-depth initialization monocular SLAM framework, showing the strengths and costs of this proposal.

  12. Monocular indoor localization techniques for smartphones

    Directory of Open Access Journals (Sweden)

    Hollósi Gergely

    2016-12-01

    Full Text Available In the last decade huge research work has been put to the indoor visual localization of personal smartphones. Considering the available sensor capabilities monocular odometry provides promising solution, even reecting requirements of augmented reality applications. This paper is aimed to give an overview of state-of-the-art results regarding monocular visual localization. For this purpose essential basics of computer vision are presented and the most promising solutions are reviewed.

  13. Monocular Video Guided Garment Simulation

    Institute of Scientific and Technical Information of China (English)

    Fa-Ming Li; Xiao-Wu Chen∗; Bin Zhou; Fei-Xiang Lu; Kan Guo; Qiang Fu

    2015-01-01

    We present a prototype to generate a garment-shape sequence guided by a monocular video sequence. It is a combination of a physically-based simulation and a boundary-based modification. Given a garment in the video worn on a mannequin, the simulation generates a garment initial shape by exploiting the mannequin shapes estimated from the video. The modification then deforms the simulated 3D shape into such a shape that matches the garment 2D boundary extracted from the video. According to the matching correspondences between the vertices on the shape and the points on the boundary, the modification is implemented by attracting the matched vertices and their neighboring vertices. For best-matching correspondences and efficient performance, three criteria are introduced to select the candidate vertices for matching. Since modifying each garment shape independently may cause inter-frame oscillations, changes by the modification are also propagated from one frame to the next frame. As a result, the generated garment 3D shape sequence is stable and similar to the garment video sequence. We demonstrate the effectiveness of our prototype with a number of examples.

  14. Cryptanalysis of MD2

    DEFF Research Database (Denmark)

    Knudsen, Lars Ramkilde; Mathiassen, John Erik; Muller, Frédéric

    2010-01-01

    This paper considers the hash function MD2 which was developed by Ron Rivest in 1989. Despite its age, MD2 has withstood cryptanalytic attacks until recently. This paper contains the state-of-the-art cryptanalytic results on MD2, in particular collision and preimage attacks on the full hash...

  15. Short-term monocular patching boosts the patched eye’s response in visual cortex

    Science.gov (United States)

    Zhou, Jiawei; Baker, Daniel H.; Simard, Mathieu; Saint-Amour, Dave; Hess, Robert F.

    2015-01-01

    Abstract Purpose: Several recent studies have demonstrated that following short-term monocular deprivation in normal adults, the patched eye, rather than the unpatched eye, becomes stronger in subsequent binocular viewing. However, little is known about the site and nature of the underlying processes. In this study, we examine the underlying mechanisms by measuring steady-state visual evoked potentials (SSVEPs) as an index of the neural contrast response in early visual areas. Methods: The experiment consisted of three consecutive stages: a pre-patching EEG recording (14 minutes), a monocular patching stage (2.5 hours) and a post-patching EEG recording (14 minutes; started immediately after the removal of the patch). During the patching stage, a diffuser (transmits light but not pattern) was placed in front of one randomly selected eye. During the EEG recording stage, contrast response functions for each eye were measured. Results: The neural responses from the patched eye increased after the removal of the patch, whilst the responses from the unpatched eye remained the same. Such phenomena occurred under both monocular and dichoptic viewing conditions. Conclusions: We interpret this eye dominance plasticity in adult human visual cortex as homeostatic intrinsic plasticity regulated by an increase of contrast-gain in the patched eye. PMID:26410580

  16. Monocular Blindness: Is It a Handicap?

    Science.gov (United States)

    Knoth, Sharon

    1995-01-01

    Students with monocular vision may be in need of special assistance and should be evaluated by a multidisciplinary team to determine whether the visual loss is affecting educational performance. This article discusses the student's eligibility for special services, difficulty in performing depth perception tasks, difficulties in specific classroom…

  17. Disparity biasing in depth from monocular occlusions.

    Science.gov (United States)

    Tsirlin, Inna; Wilcox, Laurie M; Allison, Robert S

    2011-07-15

    Monocular occlusions have been shown to play an important role in stereopsis. Among other contributions to binocular depth perception, monocular occlusions can create percepts of illusory occluding surfaces. It has been argued that the precise location in depth of these illusory occluders is based on the constraints imposed by occlusion geometry. Tsirlin et al. (2010) proposed that when these constraints are weak, the depth of the illusory occluder can be biased by a neighboring disparity-defined feature. In the present work we test this hypothesis using a variety of stimuli. We show that when monocular occlusions provide only partial constraints on the magnitude of depth of the illusory occluders, the perceived depth of the occluders can be biased by disparity-defined features in the direction unrestricted by the occlusion geometry. Using this disparity bias phenomenon we also show that in illusory occluder stimuli where disparity information is present, but weak, most observers rely on disparity while some use occlusion information instead to specify the depth of the illusory occluder. Taken together our experiments demonstrate that in binocular depth perception disparity and monocular occlusion cues interact in complex ways to resolve perceptual ambiguity. Copyright © 2011 Elsevier Ltd. All rights reserved.

  18. Does monocular visual space contain planes?

    NARCIS (Netherlands)

    Koenderink, J.J.; Albertazzi, L.; Doorn, A.J. van; Ee, R. van; Grind, W.A. van de; Kappers, A.M.L.; Lappin, J.S.; Norman, J.F.; Oomes, A.H.J.; Pas, S.F. te; Phillips, F.; Pont, S.C.; Richards, W.A.; Todd, J.T.; Verstraten, F.A.J.; Vries, S.C. de

    2010-01-01

    The issue of the existence of planes—understood as the carriers of a nexus of straight lines—in the monocular visual space of a stationary human observer has never been addressed. The most recent empirical data apply to binocular visual space and date from the 1960s (Foley, 1964). This appears to be

  19. Monocular and binocular depth discrimination thresholds.

    Science.gov (United States)

    Kaye, S B; Siddiqui, A; Ward, A; Noonan, C; Fisher, A C; Green, J R; Brown, M C; Wareing, P A; Watt, P

    1999-11-01

    Measurement of stereoacuity at varying distances, by real or simulated depth stereoacuity tests, is helpful in the evaluation of patients with binocular imbalance or strabismus. Although the cue of binocular disparity underpins stereoacuity tests, there may be variable amounts of other binocular and monocular cues inherent in a stereoacuity test. In such circumstances, a combined monocular and binocular threshold of depth discrimination may be measured--stereoacuity conventionally referring to the situation where binocular disparity giving rise to retinal disparity is the only cue present. A child-friendly variable distance stereoacuity test (VDS) was developed, with a method for determining the binocular depth threshold from the combined monocular and binocular threshold of depth of discrimination (CT). Subjects with normal binocular function, reduced binocular function, and apparently absent binocularity were included. To measure the threshold of depth discrimination, subjects were required by means of a hand control to align two electronically controlled spheres at viewing distances of 1, 3, and 6m. Stereoacuity was also measured using the TNO, Frisby, and Titmus stereoacuity tests. BTs were calculated according to the function BT= arctan (1/tan alphaC - 1/tan alphaM)(-1), where alphaC and alphaM are the angles subtended at the nodal points by objects situated at the monocular threshold (alphaM) and the combined monocular-binocular threshold (alphaC) of discrimination. In subjects with good binocularity, BTs were similar to their combined thresholds, whereas subjects with reduced and apparently absent binocularity had binocular thresholds 4 and 10 times higher than their combined thresholds (CT). The VDS binocular thresholds showed significantly higher correlation and agreement with the TNO test and the binocular thresholds of the Frisby and Titmus tests, than the corresponding combined thresholds (p = 0.0019). The VDS was found to be an easy to use real depth

  20. Early maternal deprivation retards neurodevelopment in Wistar rats

    NARCIS (Netherlands)

    Ellenbroek, B.A.; Derks, N.M.; Park, H.J.

    2005-01-01

    A single 24 h period of maternal deprivation (MD) in rats has been shown to induce, in adulthood, a number of abnormalities in brain and behaviour that also occur in patients with schizophrenia. However, the short-term behavioural effects of MD have not been studied in detail. Since patients with

  1. Quantitative perceived depth from sequential monocular decamouflage.

    Science.gov (United States)

    Brooks, K R; Gillam, B J

    2006-03-01

    We present a novel binocular stimulus without conventional disparity cues whose presence and depth are revealed by sequential monocular stimulation (delay > or = 80 ms). Vertical white lines were occluded as they passed behind an otherwise camouflaged black rectangular target. The location (and instant) of the occlusion event, decamouflaging the target's edges, differed in the two eyes. Probe settings to match the depth of the black rectangular target showed a monotonic increase with simulated depth. Control tests discounted the possibility of subjects integrating retinal disparities over an extended temporal window or using temporal disparity. Sequential monocular decamouflage was found to be as precise and accurate as conventional simultaneous stereopsis with equivalent depths and exposure durations.

  2. Monocular depth effects on perceptual fading.

    Science.gov (United States)

    Hsu, Li-Chuan; Kramer, Peter; Yeh, Su-Ling

    2010-08-06

    After prolonged viewing, a static target among moving non-targets is perceived to repeatedly disappear and reappear. An uncrossed stereoscopic disparity of the target facilitates this Motion-Induced Blindness (MIB). Here we test whether monocular depth cues can affect MIB too, and whether they can also affect perceptual fading in static displays. Experiment 1 reveals an effect of interposition: more MIB when the target appears partially covered by, than when it appears to cover, its surroundings. Experiment 2 shows that the effect is indeed due to interposition and not to the target's contours. Experiment 3 induces depth with the watercolor illusion and replicates Experiment 1. Experiments 4 and 5 replicate Experiments 1 and 3 without the use of motion. Since almost any stimulus contains a monocular depth cue, we conclude that perceived depth affects perceptual fading in almost any stimulus, whether dynamic or static. Copyright 2010 Elsevier Ltd. All rights reserved.

  3. Monocular Vision SLAM for Indoor Aerial Vehicles

    Directory of Open Access Journals (Sweden)

    Koray Çelik

    2013-01-01

    Full Text Available This paper presents a novel indoor navigation and ranging strategy via monocular camera. By exploiting the architectural orthogonality of the indoor environments, we introduce a new method to estimate range and vehicle states from a monocular camera for vision-based SLAM. The navigation strategy assumes an indoor or indoor-like manmade environment whose layout is previously unknown, GPS-denied, representable via energy based feature points, and straight architectural lines. We experimentally validate the proposed algorithms on a fully self-contained microaerial vehicle (MAV with sophisticated on-board image processing and SLAM capabilities. Building and enabling such a small aerial vehicle to fly in tight corridors is a significant technological challenge, especially in the absence of GPS signals and with limited sensing options. Experimental results show that the system is only limited by the capabilities of the camera and environmental entropy.

  4. Outdoor autonomous navigation using monocular vision

    OpenAIRE

    Royer, Eric; Bom, Jonathan; Dhome, Michel; Thuilot, Benoît; Lhuillier, Maxime; Marmoiton, Francois

    2005-01-01

    International audience; In this paper, a complete system for outdoor robot navigation is presented. It uses only monocular vision. The robot is first guided on a path by a human. During this learning step, the robot records a video sequence. From this sequence, a three dimensional map of the trajectory and the environment is built. When this map has been computed, the robot is able to follow the same trajectory by itself. Experimental results carried out with an urban electric vehicle are sho...

  5. Monocular alignment in different depth planes.

    Science.gov (United States)

    Shimono, Koichi; Wade, Nicholas J

    2002-04-01

    We examined (a) whether vertical lines at different physical horizontal positions in the same eye can appear to be aligned, and (b), if so, whether the difference between the horizontal positions of the aligned vertical lines can vary with the perceived depth between them. In two experiments, each of two vertical monocular lines was presented (in its respective rectangular area) in one field of a random-dot stereopair with binocular disparity. In Experiment 1, 15 observers were asked to align a line in an upper area with a line in a lower area. The results indicated that when the lines appeared aligned, their horizontal physical positions could differ and the direction of the difference coincided with the type of disparity of the rectangular areas; this is not consistent with the law of the visual direction of monocular stimuli. In Experiment 2, 11 observers were asked to report relative depth between the two lines and to align them. The results indicated that the difference of the horizontal position did not covary with their perceived relative depth, suggesting that the visual direction and perceived depth of the monocular line are mediated via different mechanisms.

  6. Visual SLAM for Handheld Monocular Endoscope.

    Science.gov (United States)

    Grasa, Óscar G; Bernal, Ernesto; Casado, Santiago; Gil, Ismael; Montiel, J M M

    2014-01-01

    Simultaneous localization and mapping (SLAM) methods provide real-time estimation of 3-D models from the sole input of a handheld camera, routinely in mobile robotics scenarios. Medical endoscopic sequences mimic a robotic scenario in which a handheld camera (monocular endoscope) moves along an unknown trajectory while observing an unknown cavity. However, the feasibility and accuracy of SLAM methods have not been extensively validated with human in vivo image sequences. In this work, we propose a monocular visual SLAM algorithm tailored to deal with medical image sequences in order to provide an up-to-scale 3-D map of the observed cavity and the endoscope trajectory at frame rate. The algorithm is validated over synthetic data and human in vivo sequences corresponding to 15 laparoscopic hernioplasties where accurate ground-truth distances are available. It can be concluded that the proposed procedure is: 1) noninvasive, because only a standard monocular endoscope and a surgical tool are used; 2) convenient, because only a hand-controlled exploratory motion is needed; 3) fast, because the algorithm provides the 3-D map and the trajectory in real time; 4) accurate, because it has been validated with respect to ground-truth; and 5) robust to inter-patient variability, because it has performed successfully over the validation sequences.

  7. MD SIMULATION FOR NANOCRYSTALS

    Institute of Scientific and Technical Information of China (English)

    马新玲; 杨卫

    2003-01-01

    Molecular dynamic (MD) provided an ab initio simulation for nano-scale mechanical behavior of materials, provided that the inter-atomic potential is accurately prescribed. MD is particularly suitable in simulating the formation, the deformation, and the evolution of nanocrystals under a fast strain rate. To tackle large scale system and nano-seconds time duration, parallel algorithm is desired. The present paper reviews the recent advances in MD simulation for nanocrystals with attention focused on the applications toward nanomechanics. The examined issues are: formation of nanocrystalline metals, nanoindentation on nanocrystals, fast deformation of nanocrystals, orderdisorder transition, and nano-particle impact.

  8. Muscular Dystrophy (MD)

    Science.gov (United States)

    ... fight respiratory infections. Some individuals may benefit from occupational therapy and assistive technology. Some ... (MD) are a group of more than 30 genetic diseases characterized by progressive weakness and degeneration of the ...

  9. Bayesian depth estimation from monocular natural images.

    Science.gov (United States)

    Su, Che-Chun; Cormack, Lawrence K; Bovik, Alan C

    2017-05-01

    Estimating an accurate and naturalistic dense depth map from a single monocular photographic image is a difficult problem. Nevertheless, human observers have little difficulty understanding the depth structure implied by photographs. Two-dimensional (2D) images of the real-world environment contain significant statistical information regarding the three-dimensional (3D) structure of the world that the vision system likely exploits to compute perceived depth, monocularly as well as binocularly. Toward understanding how this might be accomplished, we propose a Bayesian model of monocular depth computation that recovers detailed 3D scene structures by extracting reliable, robust, depth-sensitive statistical features from single natural images. These features are derived using well-accepted univariate natural scene statistics (NSS) models and recent bivariate/correlation NSS models that describe the relationships between 2D photographic images and their associated depth maps. This is accomplished by building a dictionary of canonical local depth patterns from which NSS features are extracted as prior information. The dictionary is used to create a multivariate Gaussian mixture (MGM) likelihood model that associates local image features with depth patterns. A simple Bayesian predictor is then used to form spatial depth estimates. The depth results produced by the model, despite its simplicity, correlate well with ground-truth depths measured by a current-generation terrestrial light detection and ranging (LIDAR) scanner. Such a strong form of statistical depth information could be used by the visual system when creating overall estimated depth maps incorporating stereopsis, accommodation, and other conditions. Indeed, even in isolation, the Bayesian predictor delivers depth estimates that are competitive with state-of-the-art "computer vision" methods that utilize highly engineered image features and sophisticated machine learning algorithms.

  10. Human skeleton proportions from monocular data

    Institute of Scientific and Technical Information of China (English)

    PENG En; LI Ling

    2006-01-01

    This paper introduces a novel method for estimating the skeleton proportions ofa human figure from monocular data.The proposed system will first automatically extract the key frames and recover the perspective camera model from the 2D data.The human skeleton proportions are then estimated from the key frames using the recovered camera model without posture reconstruction. The proposed method is tested to be simple, fast and produce satisfactory results for the input data. The human model with estimated proportions can be used in future research involving human body modeling or human motion reconstruction.

  11. MD-2 binds cholesterol.

    Science.gov (United States)

    Choi, Soo-Ho; Kim, Jungsu; Gonen, Ayelet; Viriyakosol, Suganya; Miller, Yury I

    2016-02-19

    Cholesterol is a structural component of cellular membranes, which is transported from liver to peripheral cells in the form of cholesterol esters (CE), residing in the hydrophobic core of low-density lipoprotein. Oxidized CE (OxCE) is often found in plasma and in atherosclerotic lesions of subjects with cardiovascular disease. Our earlier studies have demonstrated that OxCE activates inflammatory responses in macrophages via toll-like receptor-4 (TLR4). Here we demonstrate that cholesterol binds to myeloid differentiation-2 (MD-2), a TLR4 ancillary molecule, which is a binding receptor for bacterial lipopolysaccharide (LPS) and is indispensable for LPS-induced TLR4 dimerization and signaling. Cholesterol binding to MD-2 was competed by LPS and by OxCE-modified BSA. Furthermore, soluble MD-2 in human plasma and MD-2 in mouse atherosclerotic lesions carried cholesterol, the finding supporting the biological significance of MD-2 cholesterol binding. These results help understand the molecular basis of TLR4 activation by OxCE and mechanisms of chronic inflammation in atherosclerosis.

  12. Reversible monocular cataract simulating amaurosis fugax.

    Science.gov (United States)

    Paylor, R R; Selhorst, J B; Weinberg, R S

    1985-07-01

    In a patient having brittle, juvenile-onset diabetes, transient monocular visual loss occurred repeatedly whenever there were wide fluctuations in serum glucose. Amaurosis fugax was suspected. The visual loss differed, however, in that it persisted over a period of hours to several days. Direct observation eventually revealed that the relatively sudden change in vision of one eye was associated with opacification of the lens and was not accompanied by an afferent pupillary defect. Presumably, a hyperosmotic gradient had developed with the accumulation of glucose and sorbitol within the lens. Water was drawn inward, altering the composition of the lens fibers and thereby lowering the refractive index, forming a reversible cataract. Hypoglycemia is also hypothesized to have played a role in the formation of a higher osmotic gradient. The unilaterality of the cataract is attributed to variation in the permeability of asymmetric posterior subcapsular cataracts.

  13. Amodal completion with background determines depth from monocular gap stereopsis.

    Science.gov (United States)

    Grove, Philip M; Ben Sachtler, W L; Gillam, Barbara J

    2006-10-01

    Grove, Gillam, and Ono [Grove, P. M., Gillam, B. J., & Ono, H. (2002). Content and context of monocular regions determine perceived depth in random dot, unpaired background and phantom stereograms. Vision Research, 42, 1859-1870] reported that perceived depth in monocular gap stereograms [Gillam, B. J., Blackburn, S., & Nakayama, K. (1999). Stereopsis based on monocular gaps: Metrical encoding of depth and slant without matching contours. Vision Research, 39, 493-502] was attenuated when the color/texture in the monocular gap did not match the background. It appears that continuation of the gap with the background constitutes an important component of the stimulus conditions that allow a monocular gap in an otherwise binocular surface to be responded to as a depth step. In this report we tested this view using the conventional monocular gap stimulus of two identical grey rectangles separated by a gap in one eye but abutting to form a solid grey rectangle in the other. We compared depth seen at the gap for this stimulus with stimuli that were identical except for two additional small black squares placed at the ends of the gap. If the squares were placed stereoscopically behind the rectangle/gap configuration (appearing on the background) they interfered with the perceived depth at the gap. However when they were placed in front of the configuration this attenuation disappeared. The gap and the background were able under these conditions to complete amodally.

  14. Localization of monocular stimuli in different depth planes.

    Science.gov (United States)

    Shimono, Koichi; Tam, Wa James; Asakura, Nobuhiko; Ohmi, Masao

    2005-09-01

    We examined the phenomenon in which two physically aligned monocular stimuli appear to be non-collinear when each of them is located in binocular regions that are at different depth planes. Using monocular bars embedded in binocular random-dot areas that are at different depths, we manipulated properties of the binocular areas and examined their effect on the perceived direction and depth of the monocular stimuli. Results showed that (1) the relative visual direction and perceived depth of the monocular bars depended on the binocular disparity and the dot density of the binocular areas, and (2) the visual direction, but not the depth, depended on the width of the binocular regions. These results are consistent with the hypothesis that monocular stimuli are treated by the visual system as binocular stimuli that have acquired the properties of their binocular surrounds. Moreover, partial correlation analysis suggests that the visual system utilizes both the disparity information of the binocular areas and the perceived depth of the monocular bars in determining the relative visual direction of the bars.

  15. Sleep Deprivation and Deficiency

    Science.gov (United States)

    ... page from the NHLBI on Twitter. What Are Sleep Deprivation and Deficiency? Sleep deprivation (DEP-rih-VA- ... Rate This Content: NEXT >> Updated: June 7, 2017 Sleep Infographic Sleep Disorders & Insufficient Sleep: Improving Health through ...

  16. GABAB Receptor Antagonist CGP46381 Inhibits Form-Deprivation Myopia Development in Guinea Pigs

    Directory of Open Access Journals (Sweden)

    Zhen-Ying Cheng

    2015-01-01

    Full Text Available The aim was to investigate the effects of the GABAB receptor antagonist, CGP46381, on form-deprivation myopia (FDM in guinea pigs. Twenty-four guinea pigs had monocular visual deprivation induced using a diffuser for 11 days (day 14 to 25. The deprived eyes were treated with daily subconjunctival injections (100 μl of either 2% CGP46381, 0.2% CGP46381, or saline or received no injection. The fellow eyes were left untreated. Another six animals received no treatment. At the start and end of the treatment period, ocular refractions were measured using retinoscopy and vitreous chamber depth (VCD and axial length (AL using A-scan ultrasound. All of the deprived eyes developed relative myopia (treated versus untreated eyes, P0.05. Subconjunctival injections of CGP46381 inhibit FDM development in guinea pigs in a dose-dependent manner.

  17. Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation.

    Science.gov (United States)

    McCurry, Cortina L; Shepherd, Jason D; Tropea, Daniela; Wang, Kuan H; Bear, Mark F; Sur, Mriganka

    2010-04-01

    A myriad of mechanisms have been suggested to account for the full richness of visual cortical plasticity. We found that visual cortex lacking Arc is impervious to the effects of deprivation or experience. Using intrinsic signal imaging and chronic visually evoked potential recordings, we found that Arc(-/-) mice did not exhibit depression of deprived-eye responses or a shift in ocular dominance after brief monocular deprivation. Extended deprivation also failed to elicit a shift in ocular dominance or open-eye potentiation. Moreover, Arc(-/-) mice lacked stimulus-selective response potentiation. Although Arc(-/-) mice exhibited normal visual acuity, baseline ocular dominance was abnormal and resembled that observed after dark-rearing. These data suggest that Arc is required for the experience-dependent processes that normally establish and modify synaptic connections in visual cortex.

  18. Separating monocular and binocular neural mechanisms mediating chromatic contextual interactions.

    Science.gov (United States)

    D'Antona, Anthony D; Christiansen, Jens H; Shevell, Steven K

    2014-04-17

    When seen in isolation, a light that varies in chromaticity over time is perceived to oscillate in color. Perception of that same time-varying light may be altered by a surrounding light that is also temporally varying in chromaticity. The neural mechanisms that mediate these contextual interactions are the focus of this article. Observers viewed a central test stimulus that varied in chromaticity over time within a larger surround that also varied in chromaticity at the same temporal frequency. Center and surround were presented either to the same eye (monocular condition) or to opposite eyes (dichoptic condition) at the same frequency (3.125, 6.25, or 9.375 Hz). Relative phase between center and surround modulation was varied. In both the monocular and dichoptic conditions, the perceived modulation depth of the central light depended on the relative phase of the surround. A simple model implementing a linear combination of center and surround modulation fit the measurements well. At the lowest temporal frequency (3.125 Hz), the surround's influence was virtually identical for monocular and dichoptic conditions, suggesting that at this frequency, the surround's influence is mediated primarily by a binocular neural mechanism. At higher frequencies, the surround's influence was greater for the monocular condition than for the dichoptic condition, and this difference increased with temporal frequency. Our findings show that two separate neural mechanisms mediate chromatic contextual interactions: one binocular and dominant at lower temporal frequencies and the other monocular and dominant at higher frequencies (6-10 Hz).

  19. The effect of contrast on monocular versus binocular reading performance.

    Science.gov (United States)

    Johansson, Jan; Pansell, Tony; Ygge, Jan; Seimyr, Gustaf Öqvist

    2014-05-14

    The binocular advantage in reading performance is typically small. On the other hand research shows binocular reading to be remarkably robust to degraded stimulus properties. We hypothesized that this robustness may stem from an increasing binocular contribution. The main objective was to compare monocular and binocular performance at different stimulus contrasts and assess the level of binocular superiority. A secondary objective was to assess any asymmetry in performance related to ocular dominance. In a balanced repeated measures experiment 18 subjects read texts at three levels of contrast monocularly and binocularly while their eye movements were recorded. The binocular advantage increased with reduced contrast producing a 7% slower monocular reading at 40% contrast, 9% slower at 20% contrast, and 21% slower at 10% contrast. A statistically significant interaction effect was found in fixation duration displaying a more adverse effect in the monocular condition at lowest contrast. No significant effects of ocular dominance were observed. The outcome suggests that binocularity contributes increasingly to reading performance as stimulus contrast decreases. The strongest difference between monocular and binocular performance was due to fixation duration. The findings may pose a clinical point that it may be necessary to consider tests at different contrast levels when estimating reading performance. © 2014 ARVO.

  20. Hazard detection with a monocular bioptic telescope.

    Science.gov (United States)

    Doherty, Amy L; Peli, Eli; Luo, Gang

    2015-09-01

    The safety of bioptic telescopes for driving remains controversial. The ring scotoma, an area to the telescope eye due to the telescope magnification, has been the main cause of concern. This study evaluates whether bioptic users can use the fellow eye to detect in hazards driving videos that fall in the ring scotoma area. Twelve visually impaired bioptic users watched a series of driving hazard perception training videos and responded as soon as they detected a hazard while reading aloud letters presented on the screen. The letters were placed such that when reading them through the telescope the hazard fell in the ring scotoma area. Four conditions were tested: no bioptic and no reading, reading without bioptic, reading with a bioptic that did not occlude the fellow eye (non-occluding bioptic), and reading with a bioptic that partially-occluded the fellow eye. Eight normally sighted subjects performed the same task with the partially occluding bioptic detecting lateral hazards (blocked by the device scotoma) and vertical hazards (outside the scotoma) to further determine the cause-and-effect relationship between hazard detection and the fellow eye. There were significant differences in performance between conditions: 83% of hazards were detected with no reading task, dropping to 67% in the reading task with no bioptic, to 50% while reading with the non-occluding bioptic, and 34% while reading with the partially occluding bioptic. For normally sighted, detection of vertical hazards (53%) was significantly higher than lateral hazards (38%) with the partially occluding bioptic. Detection of driving hazards is impaired by the addition of a secondary reading like task. Detection is further impaired when reading through a monocular telescope. The effect of the partially-occluding bioptic supports the role of the non-occluded fellow eye in compensating for the ring scotoma. © 2015 The Authors Ophthalmic & Physiological Optics © 2015 The College of Optometrists.

  1. Monocular Road Detection Using Structured Random Forest

    Directory of Open Access Journals (Sweden)

    Liang Xiao

    2016-05-01

    Full Text Available Road detection is a key task for autonomous land vehicles. Monocular vision-based road detection algorithms are mostly based on machine learning approaches and are usually cast as classification problems. However, the pixel-wise classifiers are faced with the ambiguity caused by changes in road appearance, illumination and weather. An effective way to reduce the ambiguity is to model the contextual information with structured learning and prediction. Currently, the widely used structured prediction model in road detection is the Markov random field or conditional random field. However, the random field-based methods require additional complex optimization after pixel-wise classification, making them unsuitable for real-time applications. In this paper, we present a structured random forest-based road-detection algorithm which is capable of modelling the contextual information efficiently. By mapping the structured label space to a discrete label space, the test function of each split node can be trained in a similar way to that of the classical random forests. Structured random forests make use of the contextual information of image patches as well as the structural information of the labels to get more consistent results. Besides this benefit, by predicting a batch of pixels in a single classification, the structured random forest-based road detection can be much more efficient than the conventional pixel-wise random forest. Experimental results tested on the KITTI-ROAD dataset and data collected in typical unstructured environments show that structured random forest-based road detection outperforms the classical pixel-wise random forest both in accuracy and efficiency.

  2. Arnold Aberman, MD.

    Science.gov (United States)

    Aberman, A

    1995-10-01

    When the United States embarked on its effort to provide universal health insurance, the Canadian Medicare System was cited as a possible model for American health care. Often touted as an example of low-cost, high quality medicine, the Canadian system has mirrored the problems of health care across its southern border. With rocketing health care expenditures and financing having largely been decentralized to the individual provinces, local officials have struggled to cut costs and services. A central focus of these efforts has been a move to decrease the numbers of physicians, most notably a 10% decrease in medical school class size in 1993. While some Western provinces have experimented with the privatization of health care, the Canadian system still remains the epitome of government operated fee-for-service medicine. Given the likelihood of dramatic change in the American Medicare system, Canadian academic centers offer a unique perspective on the impact of capitation, evolving relationships with government payors, and the flip side of market oriented reforms. At the helm of one of Canada's largest schools is Arnold Aberman, MD, dean of the University of Toronto Faculty of Medicine. Born in Montreal, Quebec, Aberman received his MD from McGill University, but then did his residency both in Canada and the US, followed by a pulmonary fellowship at Albert Einstein College of Medicine and the Cardiovascular Research Institute of the University of California, San Francisco. Interviewed at his office in Toronto, Aberman reflected on the trials and tribulations confronting medicine on both sides of the 48th parallel.

  3. Ernst Mach and the episode of the monocular depth sensations.

    Science.gov (United States)

    Banks, E C

    2001-01-01

    Although Ernst Mach is widely recognized in psychology for his discovery of the effects of lateral inhibition in the retina ("Mach Bands"), his contributions to the theory of depth perception are not as well known. Mach proposed that steady luminance gradients triggered sensations of depth. He also expanded on Ewald Hering's hypothesis of "monocular depth sensations," arguing that they were subject to the same principle of lateral inhibition as light sensations were. Even after Hermann von Helmholtz's attack on Hering in 1866, Mach continued to develop theories involving the monocular depth sensations, proposing an explanation of perspective drawings in which the mutually inhibiting depth sensations scaled to a mean depth. Mach also contemplated a theory of stereopsis in which monocular depth perception played the primary role. Copyright 2001 John Wiley & Sons, Inc.

  4. A Comparison of Monocular and Binocular Depth Perception in 5- and 7-Month-Old Infants.

    Science.gov (United States)

    Granrud, Carl E.; And Others

    1984-01-01

    Compares monocular depth perception with binocular depth perception in five- to seven-month-old infants. Reaching preferences (dependent measure) observed in the monocular condition indicated sensitivity to monocular depth information. Binocular viewing resulted in a far more consistent tendency to reach for the nearer object. (Author)

  5. The Influence of Monocular Spatial Cues on Vergence Eye Movements in Monocular and Binocular Viewing of 3-D and 2-D Stimuli.

    Science.gov (United States)

    Batvinionak, Anton A; Gracheva, Maria A; Bolshakov, Andrey S; Rozhkova, Galina I

    2015-01-01

    The influence of monocular spatial cues on the vergence eye movements was studied in two series of experiments: (I) the subjects were viewing a 3-D video and also its 2-D version-binocularly and monocularly; and (II) in binocular and monocular viewing conditions, the subjects were presented with stationary 2-D stimuli containing or not containing some monocular indications of spatial arrangement. The results of the series (I) showed that, in binocular viewing conditions, the vergence eye movements were only present in the case of 3-D but not 2-D video, while in the course of monocular viewing of 2-D video, some regular vergence eye movements could be revealed, suggesting that the occluded eye position could be influenced by the spatial organization of the scene reconstructed on the basis of the monocular depth information provided by the viewing eye. The data obtained in series (II), in general, seem to support this hypothesis. © The Author(s) 2015.

  6. ADT fast losses MD

    CERN Document Server

    Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

    2013-01-01

    The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

  7. Parallax error in the monocular head-mounted eye trackers

    DEFF Research Database (Denmark)

    Mardanbeigi, Diako; Witzner Hansen, Dan

    2012-01-01

    This paper investigates the parallax error, which is a common problem of many video-based monocular mobile gaze trackers. The parallax error is defined and described using the epipolar geometry in a stereo camera setup. The main parameters that change the error are introduced and it is shown how...

  8. Monocular SLAM for Autonomous Robots with Enhanced Features Initialization

    Directory of Open Access Journals (Sweden)

    Edmundo Guerra

    2014-04-01

    Full Text Available This work presents a variant approach to the monocular SLAM problem focused in exploiting the advantages of a human-robot interaction (HRI framework. Based upon the delayed inverse-depth feature initialization SLAM (DI-D SLAM, a known monocular technique, several but crucial modifications are introduced taking advantage of data from a secondary monocular sensor, assuming that this second camera is worn by a human. The human explores an unknown environment with the robot, and when their fields of view coincide, the cameras are considered a pseudo-calibrated stereo rig to produce estimations for depth through parallax. These depth estimations are used to solve a related problem with DI-D monocular SLAM, namely, the requirement of a metric scale initialization through known artificial landmarks. The same process is used to improve the performance of the technique when introducing new landmarks into the map. The convenience of the approach taken to the stereo estimation, based on SURF features matching, is discussed. Experimental validation is provided through results from real data with results showing the improvements in terms of more features correctly initialized, with reduced uncertainty, thus reducing scale and orientation drift. Additional discussion in terms of how a real-time implementation could take advantage of this approach is provided.

  9. Monocular 3D display system for presenting correct depth

    Science.gov (United States)

    Sakamoto, Kunio; Hosomi, Takashi

    2009-10-01

    The human vision system has visual functions for viewing 3D images with a correct depth. These functions are called accommodation, vergence and binocular stereopsis. Most 3D display system utilizes binocular stereopsis. The authors have developed a monocular 3D vision system with accommodation mechanism, which is useful function for perceiving depth.

  10. Monocular SLAM for autonomous robots with enhanced features initialization.

    Science.gov (United States)

    Guerra, Edmundo; Munguia, Rodrigo; Grau, Antoni

    2014-04-02

    This work presents a variant approach to the monocular SLAM problem focused in exploiting the advantages of a human-robot interaction (HRI) framework. Based upon the delayed inverse-depth feature initialization SLAM (DI-D SLAM), a known monocular technique, several but crucial modifications are introduced taking advantage of data from a secondary monocular sensor, assuming that this second camera is worn by a human. The human explores an unknown environment with the robot, and when their fields of view coincide, the cameras are considered a pseudo-calibrated stereo rig to produce estimations for depth through parallax. These depth estimations are used to solve a related problem with DI-D monocular SLAM, namely, the requirement of a metric scale initialization through known artificial landmarks. The same process is used to improve the performance of the technique when introducing new landmarks into the map. The convenience of the approach taken to the stereo estimation, based on SURF features matching, is discussed. Experimental validation is provided through results from real data with results showing the improvements in terms of more features correctly initialized, with reduced uncertainty, thus reducing scale and orientation drift. Additional discussion in terms of how a real-time implementation could take advantage of this approach is provided.

  11. MD5算法研究%MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    张裔智; 赵毅; 汤小斌

    2008-01-01

    随着网络技术的迅速发展,信息加密技术已成为保障网络安全的一种重要手段,加密算法已经成为人们的一个研究热点.本文对MD5算法进行了深入研究,介绍MD5算法的产生背景、应用及其算法流程,并提出了MD5算法的一个改进方案.

  12. Monocular and binocular edges enhance the perception of stereoscopic slant.

    Science.gov (United States)

    Wardle, Susan G; Palmisano, Stephen; Gillam, Barbara J

    2014-07-01

    Gradients of absolute binocular disparity across a slanted surface are often considered the basis for stereoscopic slant perception. However, perceived stereo slant around a vertical axis is usually slow and significantly under-estimated for isolated surfaces. Perceived slant is enhanced when surrounding surfaces provide a relative disparity gradient or depth step at the edges of the slanted surface, and also in the presence of monocular occlusion regions (sidebands). Here we investigate how different kinds of depth information at surface edges enhance stereo slant about a vertical axis. In Experiment 1, perceived slant decreased with increasing surface width, suggesting that the relative disparity between the left and right edges was used to judge slant. Adding monocular sidebands increased perceived slant for all surface widths. In Experiment 2, observers matched the slant of surfaces that were isolated or had a context of either monocular or binocular sidebands in the frontal plane. Both types of sidebands significantly increased perceived slant, but the effect was greater with binocular sidebands. These results were replicated in a second paradigm in which observers matched the depth of two probe dots positioned in front of slanted surfaces (Experiment 3). A large bias occurred for the surface without sidebands, yet this bias was reduced when monocular sidebands were present, and was nearly eliminated with binocular sidebands. Our results provide evidence for the importance of edges in stereo slant perception, and show that depth from monocular occlusion geometry and binocular disparity may interact to resolve complex 3D scenes. Copyright © 2014 Elsevier B.V. All rights reserved.

  13. Visual system plasticity in mammals: the story of monocular enucleation-induced vision loss.

    Science.gov (United States)

    Nys, Julie; Scheyltjens, Isabelle; Arckens, Lutgarde

    2015-01-01

    The groundbreaking work of Hubel and Wiesel in the 1960's on ocular dominance plasticity instigated many studies of the visual system of mammals, enriching our understanding of how the development of its structure and function depends on high quality visual input through both eyes. These studies have mainly employed lid suturing, dark rearing and eye patching applied to different species to reduce or impair visual input, and have created extensive knowledge on binocular vision. However, not all aspects and types of plasticity in the visual cortex have been covered in full detail. In that regard, a more drastic deprivation method like enucleation, leading to complete vision loss appears useful as it has more widespread effects on the afferent visual pathway and even on non-visual brain regions. One-eyed vision due to monocular enucleation (ME) profoundly affects the contralateral retinorecipient subcortical and cortical structures thereby creating a powerful means to investigate cortical plasticity phenomena in which binocular competition has no vote.In this review, we will present current knowledge about the specific application of ME as an experimental tool to study visual and cross-modal brain plasticity and compare early postnatal stages up into adulthood. The structural and physiological consequences of this type of extensive sensory loss as documented and studied in several animal species and human patients will be discussed. We will summarize how ME studies have been instrumental to our current understanding of the differentiation of sensory systems and how the structure and function of cortical circuits in mammals are shaped in response to such an extensive alteration in experience. In conclusion, we will highlight future perspectives and the clinical relevance of adding ME to the list of more longstanding deprivation models in visual system research.

  14. Was cultural deprivation in fact sensory deprivation? Deprivation, retardation and intervention in the USA.

    Science.gov (United States)

    Raz, Mical

    2011-01-01

    In the 1950s, the term "deprivation" entered American psychiatric discourse. This article examines how the concept of deprivation permeated the field of mental retardation, and became an accepted theory of etiology. It focuses on sensory deprivation and cultural deprivation, and analyzes the interventions developed, based on these theories. It argues that the controversial theory of cultural deprivation derived its scientific legitimization from the theory of sensory deprivation, and was a highly politicized concept that took part in the nature-nurture debate.

  15. [Diabetes and social deprivation].

    Science.gov (United States)

    Jaffiol, Claude; Fontbonne, Annick; Vannereau, Denyse; Olive, Jean-Paul; Passeron, Serge

    2012-01-01

    Diabetes prevalence is frequently associated with low socioeconomic status (SES), but little is known about the relationship between SES and diabetes control, follow-up and quality of life. We evaluated SES by using the EPICES score, an individual index of deprivation (Evaluation de la Précarité et des Inégalités de Santé dans les Centres d'Examen de Santé; Evaluation of Precariousness and Inequalities in Health Examination Centers). A total of 1686 subjects aged from 25 to 85 years were selected at random in Montpellier and 154 in Narbonne, of whom 126 were managed by a care network including diabetologists, general practitioners and nurses. Capillary glycemia, the body mass index (BMI), waist circumference (WC), and blood pressure were measured in all the subjects. HbA1c was measured in subjects with above-normal glycemia. Five hundred sixty-four subjects from the study population (190 diabetic patients, 292 subjects with non diabetic hyperglycemia, and 86 euglycemic subjects) were clinically evaluated and asked to complete a questionnaire covering socioeconomic status and diet. The data were then compared between deprived and non deprived subjects. One hundred sixty-one diabetic patients had a clinical examination and completed a detailed questionnaire including their history, therapy, control and follow-up of diabetes, perception of diabetes, quality of life, socioeconomic status and diet. The data were then compared between deprived and non deprived patients. One hundred twenty-six diabetic subjects managed by the AUDIAB care network were compared with 163 diabetics recruited in Montpellier, based on the same investigations and the same questionnaires. The data were compared between the overall patients and between deprived and non deprived patients. In the overall population, deprived subjects were younger and more frequently smokers, and had higher BMI than non deprived subjects. The overall prevalence of type 2 diabetes was 8.1%. Among patients

  16. Disseminated neurocysticercosis presenting as isolated acute monocular painless vision loss

    Directory of Open Access Journals (Sweden)

    Gaurav M Kasundra

    2014-01-01

    Full Text Available Neurocysticercosis, the most common parasitic infection of the nervous system, is known to affect the brain, eyes, muscular tissues and subcutaneous tissues. However, it is very rare for patients with ocular cysts to have concomitant cerebral cysts. Also, the dominant clinical manifestation of patients with cerebral cysts is either seizures or headache. We report a patient who presented with acute monocular painless vision loss due to intraocular submacular cysticercosis, who on investigation had multiple cerebral parenchymal cysticercal cysts, but never had any seizures. Although such a vision loss after initiation of antiparasitic treatment has been mentioned previously, acute monocular vision loss as the presenting feature of ocular cysticercosis is rare. We present a brief review of literature along with this case report.

  17. fMRI investigation of monocular pattern rivalry.

    Science.gov (United States)

    Mendola, Janine D; Buckthought, Athena

    2013-01-01

    In monocular pattern rivalry, a composite image is shown to both eyes. The patient experiences perceptual alternations in which the two stimulus components alternate in clarity or salience. We used fMRI at 3T to image brain activity while participants perceived monocular rivalry passively or indicated their percepts with a task. The stimulus patterns were left/right oblique gratings, face/house composites, or a nonrivalrous control stimulus that did not support the perception of transparency or image segmentation. All stimuli were matched for luminance, contrast, and color. Compared with the control stimulus, the cortical activation for passive viewing of grating rivalry included dorsal and ventral extrastriate cortex, superior and inferior parietal regions, and multiple sites in frontal cortex. When the BOLD signal for the object rivalry task was compared with the grating rivalry task, a similar whole-brain network was engaged, but with significantly greater activity in extrastriate regions, including V3, V3A, fusiform face area (FFA), and parahippocampal place area (PPA). In addition, for the object rivalry task, FFA activity was significantly greater during face-dominant periods whereas parahippocampal place area activity was greater during house-dominant periods. Our results demonstrate that slight stimulus changes that trigger monocular rivalry recruit a large whole-brain network, as previously identified for other forms of bistability. Moreover, the results indicate that rivalry for complex object stimuli preferentially engages extrastriate cortex. We also establish that even with natural viewing conditions, endogenous attentional fluctuations in monocular pattern rivalry will differentially drive object-category-specific cortex, similar to binocular rivalry, but without complete suppression of the nondominant image.

  18. The effect of induced monocular blur on measures of stereoacuity.

    Science.gov (United States)

    Odell, Naomi V; Hatt, Sarah R; Leske, David A; Adams, Wendy E; Holmes, Jonathan M

    2009-04-01

    To determine the effect of induced monocular blur on stereoacuity measured with real depth and random dot tests. Monocular visual acuity deficits (range, 20/15 to 20/1600) were induced with 7 different Bangerter filters (depth tests and Preschool Randot (PSR) and Distance Randot (DR) random dot tests. Stereoacuity results were grouped as either "fine" (60 and 200 arcsec to nil) stereo. Across visual acuity deficits, stereoacuity was more severely degraded with random dot (PSR, DR) than with real depth (Frisby, FD2) tests. Degradation to worse-than-fine stereoacuity consistently occurred at 0.7 logMAR (20/100) or worse for Frisby, 0.1 logMAR (20/25) or worse for PSR, and 0.1 logMAR (20/25) or worse for FD2. There was no meaningful threshold for the DR because worse-than-fine stereoacuity was associated with -0.1 logMAR (20/15). Course/nil stereoacuity was consistently associated with 1.2 logMAR (20/320) or worse for Frisby, 0.8 logMAR (20/125) or worse for PSR, 1.1 logMAR (20/250) or worse for FD2, and 0.5 logMAR (20/63) or worse for DR. Stereoacuity thresholds are more easily degraded by reduced monocular visual acuity with the use of random dot tests (PSR and DR) than real depth tests (Frisby and FD2). We have defined levels of monocular visual acuity degradation associated with fine and nil stereoacuity. These findings have important implications for testing stereoacuity in clinical populations.

  19. A smart telerobotic system driven by monocular vision

    Science.gov (United States)

    Defigueiredo, R. J. P.; Maccato, A.; Wlczek, P.; Denney, B.; Scheerer, J.

    1994-01-01

    A robotic system that accepts autonomously generated motion and control commands is described. The system provides images from the monocular vision of a camera mounted on a robot's end effector, eliminating the need for traditional guidance targets that must be predetermined and specifically identified. The telerobotic vision system presents different views of the targeted object relative to the camera, based on a single camera image and knowledge of the target's solid geometry.

  20. Building a 3D scanner system based on monocular vision.

    Science.gov (United States)

    Zhang, Zhiyi; Yuan, Lin

    2012-04-10

    This paper proposes a three-dimensional scanner system, which is built by using an ingenious geometric construction method based on monocular vision. The system is simple, low cost, and easy to use, and the measurement results are very precise. To build it, one web camera, one handheld linear laser, and one background calibration board are required. The experimental results show that the system is robust and effective, and the scanning precision can be satisfied for normal users.

  1. Monocular nasal hemianopia from atypical sphenoid wing meningioma.

    Science.gov (United States)

    Stacy, Rebecca C; Jakobiec, Frederick A; Lessell, Simmons; Cestari, Dean M

    2010-06-01

    Neurogenic monocular nasal field defects respecting the vertical midline are quite uncommon. We report a case of a unilateral nasal hemianopia that was caused by compression of the left optic nerve by a sphenoid wing meningioma. Histological examination revealed that the pathology of the meningioma was consistent with that of an atypical meningioma, which carries a guarded prognosis with increased chance of recurrence. The tumor was debulked surgically, and the patient's visual field defect improved.

  2. Indoor monocular mobile robot navigation based on color landmarks

    Institute of Scientific and Technical Information of China (English)

    LUO Yuan; ZHANG Bai-sheng; ZHANG Yi; LI Ling

    2009-01-01

    A robot landmark navigation system based on monocular camera was researched theoretically and experimentally. First the landmark setting and its data structure in programming was given; then the coordinates of them getting by robot and global localization of the robot was described; finally experiments based on Pioneer III mobile robot show that this system can work well at different topographic situation without lose of signposts.

  3. Altered anterior visual system development following early monocular enucleation

    Directory of Open Access Journals (Sweden)

    Krista R. Kelly

    2014-01-01

    Conclusions: The novel finding of an asymmetry in morphology of the anterior visual system following long-term survival from early monocular enucleation indicates altered postnatal visual development. Possible mechanisms behind this altered development include recruitment of deafferented cells by crossing nasal fibres and/or geniculate cell retention via feedback from primary visual cortex. These data highlight the importance of balanced binocular input during postnatal maturation for typical anterior visual system morphology.

  4. A Highest Order Hypothesis Compatibility Test for Monocular SLAM

    Directory of Open Access Journals (Sweden)

    Edmundo Guerra

    2013-08-01

    Full Text Available Simultaneous Location and Mapping (SLAM is a key problem to solve in order to build truly autonomous mobile robots. SLAM with a unique camera, or monocular SLAM, is probably one of the most complex SLAM variants, based entirely on a bearing-only sensor working over six DOF. The monocular SLAM method developed in this work is based on the Delayed Inverse-Depth (DI-D Feature Initialization, with the contribution of a new data association batch validation technique, the Highest Order Hypothesis Compatibility Test, HOHCT. The Delayed Inverse-Depth technique is used to initialize new features in the system and defines a single hypothesis for the initial depth of features with the use of a stochastic technique of triangulation. The introduced HOHCT method is based on the evaluation of statistically compatible hypotheses and a search algorithm designed to exploit the strengths of the Delayed Inverse- Depth technique to achieve good performance results. This work presents the HOHCT with a detailed formulation of the monocular DI-D SLAM problem. The performance of the proposed HOHCT is validated with experimental results, in both indoor and outdoor environments, while its costs are compared with other popular approaches.

  5. A Highest Order Hypothesis Compatibility Test for Monocular SLAM

    Directory of Open Access Journals (Sweden)

    Edmundo Guerra

    2013-08-01

    Full Text Available Simultaneous Location and Mapping (SLAM is a key problem to solve in order to build truly autonomous mobile robots. SLAM with a unique camera, or monocular SLAM, is probably one of the most complex SLAM variants, based entirely on a bearing-only sensor working over six DOF. The monocular SLAM method developed in this work is based on the Delayed Inverse-Depth (DI-D Feature Initialization, with the contribution of a new data association batch validation technique, the Highest Order Hypothesis Compatibility Test, HOHCT. The Delayed Inverse-Depth technique is used to initialize new features in the system and defines a single hypothesis for the initial depth of features with the use of a stochastic technique of triangulation. The introduced HOHCT method is based on the evaluation of statistically compatible hypotheses and a search algorithm designed to exploit the strengths of the Delayed Inverse-Depth technique to achieve good performance results. This work presents the HOHCT with a detailed formulation of the monocular DI-D SLAM problem. The performance of the proposed HOHCT is validated with experimental results, in both indoor and outdoor environments, while its costs are compared with other popular approaches.

  6. High Accuracy Monocular SFM and Scale Correction for Autonomous Driving.

    Science.gov (United States)

    Song, Shiyu; Chandraker, Manmohan; Guest, Clark C

    2016-04-01

    We present a real-time monocular visual odometry system that achieves high accuracy in real-world autonomous driving applications. First, we demonstrate robust monocular SFM that exploits multithreading to handle driving scenes with large motions and rapidly changing imagery. To correct for scale drift, we use known height of the camera from the ground plane. Our second contribution is a novel data-driven mechanism for cue combination that allows highly accurate ground plane estimation by adapting observation covariances of multiple cues, such as sparse feature matching and dense inter-frame stereo, based on their relative confidences inferred from visual data on a per-frame basis. Finally, we demonstrate extensive benchmark performance and comparisons on the challenging KITTI dataset, achieving accuracy comparable to stereo and exceeding prior monocular systems. Our SFM system is optimized to output pose within 50 ms in the worst case, while average case operation is over 30 fps. Our framework also significantly boosts the accuracy of applications like object localization that rely on the ground plane.

  7. Maternal deprivation enhances behavioral vulnerability to stress associated with miR-504 expression in nucleus accumbens of rats.

    Directory of Open Access Journals (Sweden)

    Yi Zhang

    Full Text Available OBJECTIVE: In this study, the effect of maternal deprivation (MD and chronic unpredictable stress (CUS in inducing depressive behaviors and associated molecular mechanism were investigated in rats. METHODS: Maternal deprivation was established by separating pups from their mothers for 6 hours daily from postnatal day 1 to day 14. Chronic unpredictable stress was established by water deprivation, elevated open platform, food deprivation, restraint stress and electric foot shock. The depressive behaviors were determined by use of sucrose preference test and forced swim test. RESULTS: Rats in MD/CUS group exhibited lower sucrose preference rate, longer immobility time, and lighter body weights than rats in other groups (MD/control, non-MD/CUS and non-MD/control group. Meanwhile, higher miR-504 expression and lower dopamine receptor D1 (DRD1 and D2 (DRD2 expression were observed in the nucleus accumbens of rats in the MD/CUS group than in the other three groups. MiR-504 expression correlated negatively with DRD1 gene expression and sucrose preference rate in the sucrose preference test, but correlated positively with immobility time in forced swim test. Both DRD2 mRNA and protein expression correlated negatively with immobility time in forced swim test. CONCLUSION: These results suggest that MD enhances behavioral vulnerability to stress during adulthood, which is associated with the upregulation of miR-504 and downregulation of DRD2 expression in the nucleus accumbens.

  8. Deformable Surface 3D Reconstruction from Monocular Images

    CERN Document Server

    Salzmann, Matthieu

    2010-01-01

    Being able to recover the shape of 3D deformable surfaces from a single video stream would make it possible to field reconstruction systems that run on widely available hardware without requiring specialized devices. However, because many different 3D shapes can have virtually the same projection, such monocular shape recovery is inherently ambiguous. In this survey, we will review the two main classes of techniques that have proved most effective so far: The template-based methods that rely on establishing correspondences with a reference image in which the shape is already known, and non-rig

  9. Automatic gear sorting system based on monocular vision

    Directory of Open Access Journals (Sweden)

    Wenqi Wu

    2015-11-01

    Full Text Available An automatic gear sorting system based on monocular vision is proposed in this paper. A CCD camera fixed on the top of the sorting system is used to obtain the images of the gears on the conveyor belt. The gears׳ features including number of holes, number of teeth and color are extracted, which is used to categorize the gears. Photoelectric sensors are used to locate the gears׳ position and produce the trigger signals for pneumatic cylinders. The automatic gear sorting is achieved by using pneumatic actuators to push different gears into their corresponding storage boxes. The experimental results verify the validity and reliability of the proposed method and system.

  10. Monocular occlusions determine the perceived shape and depth of occluding surfaces.

    Science.gov (United States)

    Tsirlin, Inna; Wilcox, Laurie M; Allison, Robert S

    2010-06-01

    Recent experiments have established that monocular areas arising due to occlusion of one object by another contribute to stereoscopic depth perception. It has been suggested that the primary role of monocular occlusions is to define depth discontinuities and object boundaries in depth. Here we use a carefully designed stimulus to demonstrate empirically that monocular occlusions play an important role in localizing depth edges and defining the shape of the occluding surfaces in depth. We show that the depth perceived via occlusion in our stimuli is not due to the presence of binocular disparity at the boundary and discuss the quantitative nature of depth perception in our stimuli. Our data suggest that the visual system can use monocular information to estimate not only the sign of the depth of the occluding surface but also its magnitude. We also provide preliminary evidence that perceived depth of illusory occluders derived from monocular information can be biased by binocular features.

  11. Monocular accommodation condition in 3D display types through geometrical optics

    Science.gov (United States)

    Kim, Sung-Kyu; Kim, Dong-Wook; Park, Min-Chul; Son, Jung-Young

    2007-09-01

    Eye fatigue or strain phenomenon in 3D display environment is a significant problem for 3D display commercialization. The 3D display systems like eyeglasses type stereoscopic or auto-stereoscopic multiview, Super Multi-View (SMV), and Multi-Focus (MF) displays are considered for detail calculation about satisfaction level of monocular accommodation by geometrical optics calculation means. A lens with fixed focal length is used for experimental verification about numerical calculation of monocular defocus effect caused by accommodation at three different depths. And the simulation and experiment results consistently show relatively high level satisfaction about monocular accommodation at MF display condition. Additionally, possibility of monocular depth perception, 3D effect, at monocular MF display is discussed.

  12. Sleep deprivation and false memories.

    Science.gov (United States)

    Frenda, Steven J; Patihis, Lawrence; Loftus, Elizabeth F; Lewis, Holly C; Fenn, Kimberly M

    2014-09-01

    Many studies have investigated factors that affect susceptibility to false memories. However, few have investigated the role of sleep deprivation in the formation of false memories, despite overwhelming evidence that sleep deprivation impairs cognitive function. We examined the relationship between self-reported sleep duration and false memories and the effect of 24 hr of total sleep deprivation on susceptibility to false memories. We found that under certain conditions, sleep deprivation can increase the risk of developing false memories. Specifically, sleep deprivation increased false memories in a misinformation task when participants were sleep deprived during event encoding, but did not have a significant effect when the deprivation occurred after event encoding. These experiments are the first to investigate the effect of sleep deprivation on susceptibility to false memories, which can have dire consequences.

  13. MD 751: Train Instability Threshold

    CERN Document Server

    Carver, Lee Robert; Metral, Elias; Salvant, Benoit; Levens, Tom; Nisbet, David; Zobov, M; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the octupole current thresholds for stability for a single bunch, and then make an immediate comparison (with the same operational settings) for a train of 72 bunches separated by 25ns. From theory, the expected thresholds should be similar. Any discrepancy between the two cases will be of great interest as it could indicate the presence of additional mechanisms that contribute to the instability threshold, for example electron cloud.

  14. Maternal deprivation induces a rapid decline in circulating leptin levels and sexually dimorphic modifications in hypothalamic trophic factors and cell turnover.

    Science.gov (United States)

    Viveros, María-Paz; Díaz, Francisca; Mateos, Beatriz; Rodríguez, Noé; Chowen, Julie A

    2010-04-01

    Pathological outcomes, including metabolic and endocrine disturbances, of maternal deprivation (MD) in Wistar rats depend on gender and the timing of deprivation during development. We analyzed the effect of MD between postnatal days 9 and 10, a critical period in hypothalamic development, on circulating hormones and local production of trophic factors involved in this process, as well as on markers of cell turnover and maturation. Males and females were studied 12 and 24 h after MD and 12 h (MD36) after returning the dam to her pups. Circulating corticosterone levels were increased and glucose and leptin levels decreased throughout the study in both sexes. Hypothalamic mRNA levels of leptin receptor increased significantly at MD24 in both sexes, normalizing in females at MD36, but not in males. In male rats insulin-like growth factor mRNA levels were significantly decreased at MD24 and brain derived neurotrophic factor mRNA levels decreased at MD12 and MD24, with both trophic factors unaffected in females. In males cell proliferation was significantly decreased at MD36, as were the glial structural proteins, glial fibrillary acidic protein and vimentin. In females, nestin levels decreased significantly at MD24. These results indicate that MD differently affects trophic factors and cell-turnover in the hypothalamus of males and females, which may underlie the sex differences seen in the endocrine and metabolic outcome.

  15. Monocular camera and IMU integration for indoor position estimation.

    Science.gov (United States)

    Zhang, Yinlong; Tan, Jindong; Zeng, Ziming; Liang, Wei; Xia, Ye

    2014-01-01

    This paper presents a monocular camera (MC) and inertial measurement unit (IMU) integrated approach for indoor position estimation. Unlike the traditional estimation methods, we fix the monocular camera downward to the floor and collect successive frames where textures are orderly distributed and feature points robustly detected, rather than using forward oriented camera in sampling unknown and disordered scenes with pre-determined frame rate and auto-focus metric scale. Meanwhile, camera adopts the constant metric scale and adaptive frame rate determined by IMU data. Furthermore, the corresponding distinctive image feature point matching approaches are employed for visual localizing, i.e., optical flow for fast motion mode; Canny Edge Detector & Harris Feature Point Detector & Sift Descriptor for slow motion mode. For superfast motion and abrupt rotation where images from camera are blurred and unusable, the Extended Kalman Filter is exploited to estimate IMU outputs and to derive the corresponding trajectory. Experimental results validate that our proposed method is effective and accurate in indoor positioning. Since our system is computationally efficient and in compact size, it's well suited for visually impaired people indoor navigation and wheelchaired people indoor localization.

  16. Surface formation and depth in monocular scene perception.

    Science.gov (United States)

    Albert, M K

    1999-01-01

    The visual perception of monocular stimuli perceived as 3-D objects has received considerable attention from researchers in human and machine vision. However, most previous research has focused on how individual 3-D objects are perceived. Here this is extended to a study of how the structure of 3-D scenes containing multiple, possibly disconnected objects and features is perceived. Da Vinci stereopsis, stereo capture, and other surface formation and interpolation phenomena in stereopsis and structure-from-motion suggest that small features having ambiguous depth may be assigned depth by interpolation with features having unambiguous depth. I investigated whether vision may use similar mechanisms to assign relative depth to multiple objects and features in sparse monocular images, such as line drawings, especially when other depth cues are absent. I propose that vision tends to organize disconnected objects and features into common surfaces to construct 3-D-scene interpretations. Interpolations that are too weak to generate a visible surface percept may still be strong enough to assign relative depth to objects within a scene. When there exists more than one possible surface interpolation in a scene, the visual system's preference for one interpolation over another seems to be influenced by a number of factors, including: (i) proximity, (ii) smoothness, (iii) a preference for roughly frontoparallel surfaces and 'ground' surfaces, (iv) attention and fixation, and (v) higher-level factors. I present a variety of demonstrations and an experiment to support this surface-formation hypothesis.

  17. A Novel Metric Online Monocular SLAM Approach for Indoor Applications

    Directory of Open Access Journals (Sweden)

    Yongfei Li

    2016-01-01

    Full Text Available Monocular SLAM has attracted more attention recently due to its flexibility and being economic. In this paper, a novel metric online direct monocular SLAM approach is proposed, which can obtain the metric reconstruction of the scene. In the proposed approach, a chessboard is utilized to provide initial depth map and scale correction information during the SLAM process. The involved chessboard provides the absolute scale of scene, and it is seen as a bridge between the camera visual coordinate and the world coordinate. The scene is reconstructed as a series of key frames with their poses and correlative semidense depth maps, using a highly accurate pose estimation achieved by direct grid point-based alignment. The estimated pose is coupled with depth map estimation calculated by filtering over a large number of pixelwise small-baseline stereo comparisons. In addition, this paper formulates the scale-drift model among key frames and the calibration chessboard is used to correct the accumulated pose error. At the end of this paper, several indoor experiments are conducted. The results suggest that the proposed approach is able to achieve higher reconstruction accuracy when compared with the traditional LSD-SLAM approach. And the approach can also run in real time on a commonly used computer.

  18. Human Pose Estimation from Monocular Images: A Comprehensive Survey

    Directory of Open Access Journals (Sweden)

    Wenjuan Gong

    2016-11-01

    Full Text Available Human pose estimation refers to the estimation of the location of body parts and how they are connected in an image. Human pose estimation from monocular images has wide applications (e.g., image indexing. Several surveys on human pose estimation can be found in the literature, but they focus on a certain category; for example, model-based approaches or human motion analysis, etc. As far as we know, an overall review of this problem domain has yet to be provided. Furthermore, recent advancements based on deep learning have brought novel algorithms for this problem. In this paper, a comprehensive survey of human pose estimation from monocular images is carried out including milestone works and recent advancements. Based on one standard pipeline for the solution of computer vision problems, this survey splits the problem into several modules: feature extraction and description, human body models, and modeling methods. Problem modeling methods are approached based on two means of categorization in this survey. One way to categorize includes top-down and bottom-up methods, and another way includes generative and discriminative methods. Considering the fact that one direct application of human pose estimation is to provide initialization for automatic video surveillance, there are additional sections for motion-related methods in all modules: motion features, motion models, and motion-based methods. Finally, the paper also collects 26 publicly available data sets for validation and provides error measurement methods that are frequently used.

  19. Relative deprivation and intergroup prejudice

    NARCIS (Netherlands)

    T.F. Pettigrew; O. Christ; U. Wagner; R.W. Meertens; R. van Dick; A. Zick

    2008-01-01

    Using three diverse European surveys, we test the relationship between relative deprivation (RD) and anti-immigrant prejudice. We find that both group relative deprivation (GRD) and individual relative deprivation (IRD) are found primarily among working-class respondents who are politically alienate

  20. Relative deprivation and intergroup prejudice

    NARCIS (Netherlands)

    Pettigrew, T.F.; Christ, O.; Wagner, U.; Meertens, R.W.; van Dick, R.; Zick, A.

    2008-01-01

    Using three diverse European surveys, we test the relationship between relative deprivation (RD) and anti-immigrant prejudice. We find that both group relative deprivation (GRD) and individual relative deprivation (IRD) are found primarily among working-class respondents who are politically

  1. Sleep deprivation and depression

    NARCIS (Netherlands)

    Elsenga, Simon

    1992-01-01

    The association between depression and sleep disturbances is perhaps as old as makind. In view of the longstanding experience with this association it is amazing that only some 20 years ago, a few depressed patients attracted attention to the fact that Total Sleep Deprivation (TSD) had

  2. Sleep deprivation and depression

    NARCIS (Netherlands)

    Elsenga, Simon

    1992-01-01

    The association between depression and sleep disturbances is perhaps as old as makind. In view of the longstanding experience with this association it is amazing that only some 20 years ago, a few depressed patients attracted attention to the fact that Total Sleep Deprivation (TSD) had antidepressan

  3. 76 FR 53346 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-08-26

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Jersey Avenue, SE., Washington, DC 20590. Hand Delivery: Deliver to Mail address above between 9 a.m. and...) This AD applies to The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83),...

  4. 76 FR 41651 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-07-15

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Ground Floor, Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590. FOR FURTHER INFORMATION...) This AD applies to The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83),...

  5. Saccade amplitude disconjugacy induced by aniseikonia: role of monocular depth cues.

    Science.gov (United States)

    Pia Bucci, M; Kapoula, Z; Eggert, T

    1999-09-01

    The conjugacy of saccades is rapidly modified if the images are made unequal for the two eyes. Disconjugacy persists even in the absence of disparity which indicates learning. Binocular visual disparity is a major cue to depth and is believed to drive the disconjugacy of saccades to aniseikonic images. The goal of the present study was to test whether monocular depth cues can also influence the disconjugacy of saccades. Three experiments were performed in which subjects were exposed for 15-20 min to a 10% image size inequality. Three different images were used: a grid that contained a single monocular depth cue strongly indicating a frontoparallel plane; a random-dot pattern that contained a less prominent monocular depth cue (absence of texture gradient) which also indicates the frontoparallel plane; and a complex image with several overlapping geometric forms that contained a variety of monocular depth cues. Saccades became disconjugate in all three experiments. The disconjugacy was larger and more persistent for the experiment using the random-dot pattern that had the least prominent monocular depth cues. The complex image which had a large variety of monocular depth cues produced the most variable and less persistent disconjugacy. We conclude that the monocular depth cues modulate the disconjugacy of saccades stimulated by the disparity of aniseikonic images.

  6. Monocular 3D display unit using soft actuator for parallax image shift

    Science.gov (United States)

    Sakamoto, Kunio; Kodama, Yuuki

    2010-11-01

    The human vision system has visual functions for viewing 3D images with a correct depth. These functions are called accommodation, vergence and binocular stereopsis. Most 3D display system utilizes binocular stereopsis. The authors have developed a monocular 3D vision system with accommodation mechanism, which is useful function for perceiving depth. This vision unit needs an image shift optics for generating monocular parallax images. But conventional image shift mechanism is heavy because of its linear actuator system. To improve this problem, we developed a light-weight 3D vision unit for presenting monocular stereoscopic images using a soft linear actuator made of a polypyrrole film.

  7. Light-weight monocular display unit for 3D display using polypyrrole film actuator

    Science.gov (United States)

    Sakamoto, Kunio; Ohmori, Koji

    2010-10-01

    The human vision system has visual functions for viewing 3D images with a correct depth. These functions are called accommodation, vergence and binocular stereopsis. Most 3D display system utilizes binocular stereopsis. The authors have developed a monocular 3D vision system with accommodation mechanism, which is useful function for perceiving depth. This vision unit needs an image shift optics for generating monocular parallax images. But conventional image shift mechanism is heavy because of its linear actuator system. To improve this problem, we developed a light-weight 3D vision unit for presenting monocular stereoscopic images using a polypyrrole linear actuator.

  8. Novel approach for mobile robot localization using monocular vision

    Science.gov (United States)

    Zhong, Zhiguang; Yi, Jianqiang; Zhao, Dongbin; Hong, Yiping

    2003-09-01

    This paper presents a novel approach for mobile robot localization using monocular vision. The proposed approach locates a robot relative to the target to which the robot moves. Two points are selected from the target as two feature points. Once the coordinates in an image of the two feature points are detected, the position and motion direction of the robot can be determined according to the detected coordinates. Unlike those reported geometry pose estimation or landmarks matching methods, this approach requires neither artificial landmarks nor an accurate map of indoor environment. It needs less computation and can simplify greatly the localization problem. The validity and flexibility of the proposed approach is demonstrated by experiments performed on real images. The results show that this new approach is not only simple and flexible but also has high localization precision.

  9. A low cost PSD-based monocular motion capture system

    Science.gov (United States)

    Ryu, Young Kee; Oh, Choonsuk

    2007-10-01

    This paper describes a monocular PSD-based motion capture sensor to employ with commercial video game systems such as Microsoft's XBOX and Sony's Playstation II. The system is compact, low-cost, and only requires a one-time calibration at the factory. The system includes a PSD(Position Sensitive Detector) and active infrared (IR) LED markers that are placed on the object to be tracked. The PSD sensor is placed in the focal plane of a wide-angle lens. The micro-controller calculates the 3D position of the markers using only the measured intensity and the 2D position on the PSD. A series of experiments were performed to evaluate the performance of our prototype system. From the experimental results we see that the proposed system has the advantages of the compact size, the low cost, the easy installation, and the high frame rates to be suitable for high speed motion tracking in games.

  10. Markerless monocular tracking system for guided external eye surgery.

    Science.gov (United States)

    Monserrat, C; Rupérez, M J; Alcañiz, M; Mataix, J

    2014-12-01

    This paper presents a novel markerless monocular tracking system aimed at guiding ophthalmologists during external eye surgery. This new tracking system performs a very accurate tracking of the eye by detecting invariant points using only textures that are present in the sclera, i.e., without using traditional features like the pupil and/or cornea reflections, which remain partially or totally occluded in most surgeries. Two known algorithms that compute invariant points and correspondences between pairs of images were implemented in our system: Scalable Invariant Feature Transforms (SIFT) and Speed Up Robust Features (SURF). The results of experiments performed on phantom eyes show that, with either algorithm, the developed system tracks a sphere at a 360° rotation angle with an error that is lower than 0.5%. Some experiments have also been carried out on images of real eyes showing promising behavior of the system in the presence of blood or surgical instruments during real eye surgery.

  11. Monocular vision based navigation method of mobile robot

    Institute of Scientific and Technical Information of China (English)

    DONG Ji-wen; YANG Sen; LU Shou-yin

    2009-01-01

    A trajectory tracking method is presented for the visual navigation of the monocular mobile robot. The robot move along line trajectory drawn beforehand, recognized and stop on the stop-sign to finish special task. The robot uses a forward looking colorful digital camera to capture information in front of the robot, and by the use of HSI model partition the trajectory and the stop-sign out. Then the "sampling estimate" method was used to calculate the navigation parameters. The stop-sign is easily recognized and can identify 256 different signs. Tests indicate that the method can fit large-scale intensity of brightness and has more robustness and better real-time character.

  12. Monocular Obstacle Detection for Real-World Environments

    Science.gov (United States)

    Einhorn, Erik; Schroeter, Christof; Gross, Horst-Michael

    In this paper, we present a feature based approach for monocular scene reconstruction based on extended Kaiman filters (EKF). Our method processes a sequence of images taken by a single camera mounted in front of a mobile robot. Using various techniques we are able to produce a precise reconstruction that is almost free from outliers and therefore can be used for reliable obstacle detection and avoidance. In real-world field tests we show that the presented approach is able to detect obstacles that can not be seen by other sensors, such as laser range finders. Furthermore, we show that visual obstacle detection combined with a laser range finder can increase the detection rate of obstacles considerably, allowing the autonomous use of mobile robots in complex public and home environments.

  13. Monocular 3D scene reconstruction at absolute scale

    Science.gov (United States)

    Wöhler, Christian; d'Angelo, Pablo; Krüger, Lars; Kuhl, Annika; Groß, Horst-Michael

    In this article we propose a method for combining geometric and real-aperture methods for monocular three-dimensional (3D) reconstruction of static scenes at absolute scale. Our algorithm relies on a sequence of images of the object acquired by a monocular camera of fixed focal setting from different viewpoints. Object features are tracked over a range of distances from the camera with a small depth of field, leading to a varying degree of defocus for each feature. Information on absolute depth is obtained based on a Depth-from-Defocus approach. The parameters of the point spread functions estimated by Depth-from-Defocus are used as a regularisation term for Structure-from-Motion. The reprojection error obtained from bundle adjustment and the absolute depth error obtained from Depth-from-Defocus are simultaneously minimised for all tracked object features. The proposed method yields absolutely scaled 3D coordinates of the scene points without any prior knowledge about scene structure and camera motion. We describe the implementation of the proposed method both as an offline and as an online algorithm. Evaluating the algorithm on real-world data, we demonstrate that it yields typical relative scale errors of a few per cent. We examine the influence of random effects, i.e. the noise of the pixel grey values, and systematic effects, caused by thermal expansion of the optical system or by inclusion of strongly blurred images, on the accuracy of the 3D reconstruction result. Possible applications of our approach are in the field of industrial quality inspection; in particular, it is preferable to stereo cameras in industrial vision systems with space limitations or where strong vibrations occur.

  14. Detrimental psychophysiological effects of early maternal deprivation in adolescent and adult rodents: altered responses to cannabinoid exposure.

    Science.gov (United States)

    Marco, Eva M; Adriani, Walter; Llorente, Ricardo; Laviola, Giovanni; Viveros, María-Paz

    2009-04-01

    Environmental rearing conditions during the neonatal period are critical for the establishment of neurobiological factors controlling behavior and stress responsiveness. Early maternal deprivation (MD), consisting of a single 24-h maternal deprivation episode during early neonatal life, has been proposed as an animal model for certain psychopathologies including anxiety, depression and schizophrenic-related disorders. Despite first onset of mental disorders usually occur during adolescence, characterization of MD has been mostly developed in adult animals. We review here a series of experiments that were conducted on rats and mice, in which we analyzed the psychoimmunoendocrine outcomes of MD at both adolescence and adulthood. As a whole our results indicate that MD might promote a depressive-like trait that may be present from adolescence to maturity. Maternally deprived adolescent animals also displayed altered locomotor responses, a reduced interest for social investigation and seemed prone for impulsive behavior. Therefore, MD in rodents is further confirmed as a suitable animal model for the study of neuropsychiatric disorders that might become evident during adolescence. Given the increasing consumption of cannabis derivatives among the juvenile population and the reported comorbidity of neuropsychiatric symptoms with cannabis abuse, we also discuss our results indicating altered responses of maternally deprived adolescent animals to cannabinoid compounds.

  15. 76 FR 39251 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-07-06

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Jersey Avenue, SE., Washington, DC 20590. FOR FURTHER INFORMATION CONTACT: Roger Durbin, Aerospace.... Applicability (c) This AD applies to all The Boeing Company Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83...

  16. 76 FR 1993 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-01-12

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Ground Floor, Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590. FOR FURTHER INFORMATION.... Applicability (c) This AD applies to The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83...

  17. 76 FR 13543 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-03-14

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Floor, Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590. Hand Delivery: Deliver to Mail... stabilizer is similar in design and loading to that of the Model DC-9-81 (MD-81), DC- 9-82 (MD-82),...

  18. Acuity-independent effects of visual deprivation on human visual cortex.

    Science.gov (United States)

    Hou, Chuan; Pettet, Mark W; Norcia, Anthony M

    2014-07-29

    Visual development depends on sensory input during an early developmental critical period. Deviation of the pointing direction of the two eyes (strabismus) or chronic optical blur (anisometropia) separately and together can disrupt the formation of normal binocular interactions and the development of spatial processing, leading to a loss of stereopsis and visual acuity known as amblyopia. To shed new light on how these two different forms of visual deprivation affect the development of visual cortex, we used event-related potentials (ERPs) to study the temporal evolution of visual responses in patients who had experienced either strabismus or anisometropia early in life. To make a specific statement about the locus of deprivation effects, we took advantage of a stimulation paradigm in which we could measure deprivation effects that arise either before or after a configuration-specific response to illusory contours (ICs). Extraction of ICs is known to first occur in extrastriate visual areas. Our ERP measurements indicate that deprivation via strabismus affects both the early part of the evoked response that occurs before ICs are formed as well as the later IC-selective response. Importantly, these effects are found in the normal-acuity nonamblyopic eyes of strabismic amblyopes and in both eyes of strabismic patients without amblyopia. The nonamblyopic eyes of anisometropic amblyopes, by contrast, are normal. Our results indicate that beyond the well-known effects of strabismus on the development of normal binocularity, it also affects the early stages of monocular feature processing in an acuity-independent fashion.

  19. Effect of field of view and monocular viewing on angular size judgements in an outdoor scene

    Science.gov (United States)

    Denz, E. A.; Palmer, E. A.; Ellis, S. R.

    1980-01-01

    Observers typically overestimate the angular size of distant objects. Significantly, overestimations are greater in outdoor settings than in aircraft visual-scene simulators. The effect of field of view and monocular and binocular viewing conditions on angular size estimation in an outdoor field was examined. Subjects adjusted the size of a variable triangle to match the angular size of a standard triangle set at three greater distances. Goggles were used to vary the field of view from 11.5 deg to 90 deg for both monocular and binocular viewing. In addition, an unrestricted monocular and binocular viewing condition was used. It is concluded that neither restricted fields of view similar to those present in visual simulators nor the restriction of monocular viewing causes a significant loss in depth perception in outdoor settings. Thus, neither factor should significantly affect the depth realism of visual simulators.

  20. Dynamic object recognition and tracking of mobile robot by monocular vision

    Science.gov (United States)

    Liu, Lei; Wang, Yongji

    2007-11-01

    Monocular Vision is widely used in mobile robot's motion control for its simple structure and easy using. An integrated description to distinguish and tracking the specified color targets dynamically and precisely by the Monocular Vision based on the imaging principle is the major topic of the paper. The mainline is accordance with the mechanisms of visual processing strictly, including the pretreatment and recognition processes. Specially, the color models are utilized to decrease the influence of the illumination in the paper. Some applied algorithms based on the practical application are used for image segmentation and clustering. After recognizing the target, however the monocular camera can't get depth information directly, 3D Reconstruction Principle is used to calculate the distance and direction from robot to target. To emend monocular camera reading, the laser is used after vision measuring. At last, a vision servo system is designed to realize the robot's dynamic tracking to the moving target.

  1. Apparent motion of monocular stimuli in different depth planes with lateral head movements.

    Science.gov (United States)

    Shimono, K; Tam, W J; Ono, H

    2007-04-01

    A stationary monocular stimulus appears to move concomitantly with lateral head movements when it is embedded in a stereogram representing two front-facing rectangular areas, one above the other at two different distances. In Experiment 1, we found that the extent of perceived motion of the monocular stimulus covaried with the amplitude of head movement and the disparity between the two rectangular areas (composed of random dots). In Experiment 2, we found that the extent of perceived motion of the monocular stimulus was reduced compared to that in Experiment 1 when the rectangular areas were defined only by an outline rather than by random dots. These results are discussed using the hypothesis that a monocular stimulus takes on features of the binocular surface area in which it is embedded and is perceived as though it were treated as a binocular stimulus with regards to its visual direction and visual depth.

  2. The effect of monocular depth cues on the detection of moving objects by moving observers

    National Research Council Canada - National Science Library

    Royden, Constance S; Parsons, Daniel; Travatello, Joshua

    2016-01-01

    ... and thus is an ambiguous cue. We tested whether the addition of information about the distance of objects from the observer, in the form of monocular depth cues, aided detection of moving objects...

  3. Cavity Voltage Phase Modulation MD

    CERN Document Server

    Mastoridis, Themistoklis; Molendijk, John; Timko, Helga; CERN. Geneva. ATS Department

    2016-01-01

    The LHC RF/LLRF system is currently configured for extremely stable RF voltage to minimize transient beam loading effects. The present scheme cannot be extended beyond nominal beam current since the demanded power would exceed the peak klystron power and lead to saturation. A new scheme has therefore been proposed: for beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test a new algorithm that would adjust the voltage set point to achieve the cavity phase modulation that would minimize klystron forward power.

  4. The role of monocularly visible regions in depth and surface perception.

    Science.gov (United States)

    Harris, Julie M; Wilcox, Laurie M

    2009-11-01

    The mainstream of binocular vision research has long been focused on understanding how binocular disparity is used for depth perception. In recent years, researchers have begun to explore how monocular regions in binocularly viewed scenes contribute to our perception of the three-dimensional world. Here we review the field as it currently stands, with a focus on understanding the extent to which the role of monocular regions in depth perception can be understood using extant theories of binocular vision.

  5. Response deprivation, reinforcement, and economics

    OpenAIRE

    Allison, James

    1993-01-01

    Reinforcement of an instrumental response results not from a special kind of response consequence known as a reinforcer, but from a special kind of schedule known as a response-deprivation schedule. Under the requirements of a response-deprivation schedule, the baseline rate of the instrumental response permits less than the baseline rate of the contingent response. Because reinforcement occurs only if the schedule deprives the organism of the contingent response, reinforcement cannot result ...

  6. Food deprivation : a neuroscientific perspective

    OpenAIRE

    Schupp, Harald; Renner, Britta

    2011-01-01

    Deprivation of food has powerful effects on almost every aspect of food-related anticipatory and consummatory behaviors. Prolonged periods of starving are one of the most tragic experiences of humanity and in these periods, thoughts about food crowd mental life. However, even mild periods of deprivation are effective in eliciting appetitive behaviors, including the increase of food consumption and reinforcer value of food. Neuroimaging methods provide a new avenue to study deprivation effects...

  7. Maternal Deprivation Exacerbates the Response to a High Fat Diet in a Sexually Dimorphic Manner

    Science.gov (United States)

    Mela, Virginia; Llorente-Berzal, Álvaro; Díaz, Francisca; Argente, Jesús; Viveros, María-Paz; Chowen, Julie A.

    2012-01-01

    Maternal deprivation (MD) during neonatal life has diverse long-term effects, including affectation of metabolism. Indeed, MD for 24 hours during the neonatal period reduces body weight throughout life when the animals are maintained on a normal diet. However, little information is available regarding how this early stress affects the response to increased metabolic challenges during postnatal life. We hypothesized that MD modifies the response to a high fat diet (HFD) and that this response differs between males and females. To address this question, both male and female Wistar rats were maternally deprived for 24 hours starting on the morning of postnatal day (PND) 9. Upon weaning on PND22 half of each group received a control diet (CD) and the other half HFD. MD rats of both sexes had significantly reduced accumulated food intake and weight gain compared to controls when raised on the CD. In contrast, when maintained on a HFD energy intake and weight gain did not differ between control and MD rats of either sex. However, high fat intake induced hyperleptinemia in MD rats as early as PND35, but not until PND85 in control males and control females did not become hyperleptinemic on the HFD even at PND102. High fat intake stimulated hypothalamic inflammatory markers in both male and female rats that had been exposed to MD, but not in controls. Reduced insulin sensitivity was observed only in MD males on the HFD. These results indicate that MD modifies the metabolic response to HFD intake, with this response being different between males and females. Thus, the development of obesity and secondary complications in response to high fat intake depends on numerous factors. PMID:23145019

  8. Maternal deprivation exacerbates the response to a high fat diet in a sexually dimorphic manner.

    Science.gov (United States)

    Mela, Virginia; Llorente-Berzal, Álvaro; Díaz, Francisca; Argente, Jesús; Viveros, María-Paz; Chowen, Julie A

    2012-01-01

    Maternal deprivation (MD) during neonatal life has diverse long-term effects, including affectation of metabolism. Indeed, MD for 24 hours during the neonatal period reduces body weight throughout life when the animals are maintained on a normal diet. However, little information is available regarding how this early stress affects the response to increased metabolic challenges during postnatal life. We hypothesized that MD modifies the response to a high fat diet (HFD) and that this response differs between males and females. To address this question, both male and female Wistar rats were maternally deprived for 24 hours starting on the morning of postnatal day (PND) 9. Upon weaning on PND22 half of each group received a control diet (CD) and the other half HFD. MD rats of both sexes had significantly reduced accumulated food intake and weight gain compared to controls when raised on the CD. In contrast, when maintained on a HFD energy intake and weight gain did not differ between control and MD rats of either sex. However, high fat intake induced hyperleptinemia in MD rats as early as PND35, but not until PND85 in control males and control females did not become hyperleptinemic on the HFD even at PND102. High fat intake stimulated hypothalamic inflammatory markers in both male and female rats that had been exposed to MD, but not in controls. Reduced insulin sensitivity was observed only in MD males on the HFD. These results indicate that MD modifies the metabolic response to HFD intake, with this response being different between males and females. Thus, the development of obesity and secondary complications in response to high fat intake depends on numerous factors.

  9. Maternal deprivation exacerbates the response to a high fat diet in a sexually dimorphic manner.

    Directory of Open Access Journals (Sweden)

    Virginia Mela

    Full Text Available Maternal deprivation (MD during neonatal life has diverse long-term effects, including affectation of metabolism. Indeed, MD for 24 hours during the neonatal period reduces body weight throughout life when the animals are maintained on a normal diet. However, little information is available regarding how this early stress affects the response to increased metabolic challenges during postnatal life. We hypothesized that MD modifies the response to a high fat diet (HFD and that this response differs between males and females. To address this question, both male and female Wistar rats were maternally deprived for 24 hours starting on the morning of postnatal day (PND 9. Upon weaning on PND22 half of each group received a control diet (CD and the other half HFD. MD rats of both sexes had significantly reduced accumulated food intake and weight gain compared to controls when raised on the CD. In contrast, when maintained on a HFD energy intake and weight gain did not differ between control and MD rats of either sex. However, high fat intake induced hyperleptinemia in MD rats as early as PND35, but not until PND85 in control males and control females did not become hyperleptinemic on the HFD even at PND102. High fat intake stimulated hypothalamic inflammatory markers in both male and female rats that had been exposed to MD, but not in controls. Reduced insulin sensitivity was observed only in MD males on the HFD. These results indicate that MD modifies the metabolic response to HFD intake, with this response being different between males and females. Thus, the development of obesity and secondary complications in response to high fat intake depends on numerous factors.

  10. Comparison of Subjective Refraction under Binocular and Monocular Conditions in Myopic Subjects.

    Science.gov (United States)

    Kobashi, Hidenaga; Kamiya, Kazutaka; Handa, Tomoya; Ando, Wakako; Kawamorita, Takushi; Igarashi, Akihito; Shimizu, Kimiya

    2015-07-28

    To compare subjective refraction under binocular and monocular conditions, and to investigate the clinical factors affecting the difference in spherical refraction between the two conditions. We examined thirty eyes of 30 healthy subjects. Binocular and monocular refraction without cycloplegia was measured through circular polarizing lenses in both eyes, using the Landolt-C chart of the 3D visual function trainer-ORTe. Stepwise multiple regression analysis was used to assess the relations among several pairs of variables and the difference in spherical refraction in binocular and monocular conditions. Subjective spherical refraction in the monocular condition was significantly more myopic than that in the binocular condition (p refraction (p = 0.99). The explanatory variable relevant to the difference in spherical refraction between binocular and monocular conditions was the binocular spherical refraction (p = 0.032, partial regression coefficient B = 0.029) (adjusted R(2) = 0.230). No significant correlation was seen with other clinical factors. Subjective spherical refraction in the monocular condition was significantly more myopic than that in the binocular condition. Eyes with higher degrees of myopia are more predisposed to show the large difference in spherical refraction between these two conditions.

  11. A Case of Functional (Psychogenic Monocular Hemianopia Analyzed by Measurement of Hemifield Visual Evoked Potentials

    Directory of Open Access Journals (Sweden)

    Tsuyoshi Yoneda

    2013-12-01

    Full Text Available Purpose: Functional monocular hemianopia is an extremely rare condition, for which measurement of hemifield visual evoked potentials (VEPs has not been previously described. Methods: A 14-year-old boy with functional monocular hemianopia was followed up with Goldmann perimetry and measurement of hemifield and full-field VEPs. Results: The patient had a history of monocular temporal hemianopia of the right eye following headache, nausea and ague. There was no relative afferent pupillary defect, and a color perception test was normal. Goldmann perimetry revealed a vertical monocular temporal hemianopia of the right eye; the hemianopia on the right was also detected with a binocular visual field test. Computed tomography, magnetic resonance imaging (MRI and MR angiography of the brain including the optic chiasm as well as orbital MRI revealed no abnormalities. On the basis of these results, we diagnosed the patient's condition as functional monocular hemianopia. Pattern VEPs according to the International Society for Clinical Electrophysiology of Vision (ISCEV standard were within the normal range. The hemifield pattern VEPs for the right eye showed a symmetrical latency and amplitude for nasal and temporal hemifield stimulation. One month later, the visual field defect of the patient spontaneously disappeared. Conclusions: The latency and amplitude of hemifield VEPs for a patient with functional monocular hemianopia were normal. Measurement of hemifield VEPs may thus provide an objective tool for distinguishing functional hemianopia from hemifield loss caused by an organic lesion.

  12. Content and context of monocular regions determine perceived depth in random dot, unpaired background and phantom stereograms.

    Science.gov (United States)

    Grove, Philip M; Gillam, Barbara; Ono, Hiroshi

    2002-07-01

    Perceived depth was measured for three-types of stereograms with the colour/texture of half-occluded (monocular) regions either similar to or dissimilar to that of binocular regions or background. In a two-panel random dot stereogram the monocular region was filled with texture either similar or different to the far panel or left blank. In unpaired background stereograms the monocular region either matched the background or was different in colour or texture and in phantom stereograms the monocular region matched the partially occluded object or was a different colour or texture. In all three cases depth was considerably impaired when the monocular texture did not match either the background or the more distant surface. The content and context of monocular regions as well as their position are important in determining their role as occlusion cues and thus in three-dimensional layout. We compare coincidence and accidental view accounts of these effects.

  13. Sleep Deprivation and Advice Taking

    NARCIS (Netherlands)

    Hausser, J.A.; Leder, J.; Ketturat, C.; Dresler, M.; Faber, N.S.

    2016-01-01

    Judgements and decisions in many political, economic or medical contexts are often made while sleep deprived. Furthermore, in such contexts individuals are required to integrate information provided by - more or less qualified - advisors. We asked if sleep deprivation affects advice taking. We

  14. Fast Collision Attack on MD5

    NARCIS (Netherlands)

    M.M.J. Stevens (Marc)

    2006-01-01

    textabstractIn this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to

  15. Fast Collision Attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfi

  16. Harvesting graphics power for MD simulations

    NARCIS (Netherlands)

    van Meel, J.A.; Arnold, A.; Frenkel, D.; Portegies Zwart, S.F.; Belleman, R.G.

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruentia

  17. First thoughts on MD priorities for 2012

    CERN Document Server

    Zimmermann, F; Assmann, R

    2012-01-01

    In 2012, 22 days of beam time will be allocated for LHC MDs. In this paper, after recalling the 2011 LHC MD experience, the MD rrequests for 2012 are reviewed. Three primary MD themes for 2012 can be identified: 1)pushing performance in 2012, 2)preparing for 2014/15, and 3)towards maximum luminosity. Example topics include emittance growth in collision or enhanced satellites for theme 1), 25 ns operation for 2), and ATS optics for 3). Structures lists of MD requests and topics for each theme as well as some initial thoughts on the MD priorities are presented. For certain topics, "start-of-fill MDs" are proposed in order to most efficiently use of the available beam time.

  18. 76 FR 52225 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-08-22

    ... Model DC-9-81 (MD- 81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87), and MD-88 Airplanes AGENCY... Ground Floor, Room W12-140, 1200 New Jersey Avenue, SE., Washington, DC 20590. FOR FURTHER INFORMATION... ADs (b) None. Applicability (c) This AD applies to The Boeing Company Model DC-9-81 (MD-81),...

  19. Development of a monocular vision system for robotic drilling

    Institute of Scientific and Technical Information of China (English)

    Wei-dong ZHU; Biao MEI; Guo-rui YAN; Ying-lin KE

    2014-01-01

    Robotic drilling for aerospace structures demands a high positioning accuracy of the robot, which is usually achieved through error measurement and compensation. In this paper, we report the development of a practical monocular vision system for measurement of the relative error between the drill tool center point (TCP) and the reference hole. First, the principle of relative error measurement with the vision system is explained, followed by a detailed discussion on the hardware components, software components, and system integration. The elliptical contour extraction algorithm is presented for accurate and robust reference hole detection. System calibration is of key importance to the measurement accuracy of a vision system. A new method is proposed for the simultaneous calibration of camera internal parameters and hand-eye relationship with a dedicated calibration board. Extensive measurement experiments have been performed on a robotic drilling system. Experimental results show that the measurement accuracy of the developed vision system is higher than 0.15 mm, which meets the requirement of robotic drilling for aircraft structures.

  20. Deep monocular 3D reconstruction for assisted navigation in bronchoscopy.

    Science.gov (United States)

    Visentini-Scarzanella, Marco; Sugiura, Takamasa; Kaneko, Toshimitsu; Koto, Shinichiro

    2017-07-01

    In bronchoschopy, computer vision systems for navigation assistance are an attractive low-cost solution to guide the endoscopist to target peripheral lesions for biopsy and histological analysis. We propose a decoupled deep learning architecture that projects input frames onto the domain of CT renderings, thus allowing offline training from patient-specific CT data. A fully convolutional network architecture is implemented on GPU and tested on a phantom dataset involving 32 video sequences and [Formula: see text]60k frames with aligned ground truth and renderings, which is made available as the first public dataset for bronchoscopy navigation. An average estimated depth accuracy of 1.5 mm was obtained, outperforming conventional direct depth estimation from input frames by 60%, and with a computational time of [Formula: see text]30 ms on modern GPUs. Qualitatively, the estimated depth and renderings closely resemble the ground truth. The proposed method shows a novel architecture to perform real-time monocular depth estimation without losing patient specificity in bronchoscopy. Future work will include integration within SLAM systems and collection of in vivo datasets.

  1. Global localization from monocular SLAM on a mobile phone.

    Science.gov (United States)

    Ventura, Jonathan; Arth, Clemens; Reitmayr, Gerhard; Schmalstieg, Dieter

    2014-04-01

    We propose the combination of a keyframe-based monocular SLAM system and a global localization method. The SLAM system runs locally on a camera-equipped mobile client and provides continuous, relative 6DoF pose estimation as well as keyframe images with computed camera locations. As the local map expands, a server process localizes the keyframes with a pre-made, globally-registered map and returns the global registration correction to the mobile client. The localization result is updated each time a keyframe is added, and observations of global anchor points are added to the client-side bundle adjustment process to further refine the SLAM map registration and limit drift. The end result is a 6DoF tracking and mapping system which provides globally registered tracking in real-time on a mobile device, overcomes the difficulties of localization with a narrow field-of-view mobile phone camera, and is not limited to tracking only in areas covered by the offline reconstruction.

  2. Monocular visual scene understanding: understanding multi-object traffic scenes.

    Science.gov (United States)

    Wojek, Christian; Walk, Stefan; Roth, Stefan; Schindler, Konrad; Schiele, Bernt

    2013-04-01

    Following recent advances in detection, context modeling, and tracking, scene understanding has been the focus of renewed interest in computer vision research. This paper presents a novel probabilistic 3D scene model that integrates state-of-the-art multiclass object detection, object tracking and scene labeling together with geometric 3D reasoning. Our model is able to represent complex object interactions such as inter-object occlusion, physical exclusion between objects, and geometric context. Inference in this model allows us to jointly recover the 3D scene context and perform 3D multi-object tracking from a mobile observer, for objects of multiple categories, using only monocular video as input. Contrary to many other approaches, our system performs explicit occlusion reasoning and is therefore capable of tracking objects that are partially occluded for extended periods of time, or objects that have never been observed to their full extent. In addition, we show that a joint scene tracklet model for the evidence collected over multiple frames substantially improves performance. The approach is evaluated for different types of challenging onboard sequences. We first show a substantial improvement to the state of the art in 3D multipeople tracking. Moreover, a similar performance gain is achieved for multiclass 3D tracking of cars and trucks on a challenging dataset.

  3. 3D environment capture from monocular video and inertial data

    Science.gov (United States)

    Clark, R. Robert; Lin, Michael H.; Taylor, Colin J.

    2006-02-01

    This paper presents experimental methods and results for 3D environment reconstruction from monocular video augmented with inertial data. One application targets sparsely furnished room interiors, using high quality handheld video with a normal field of view, and linear accelerations and angular velocities from an attached inertial measurement unit. A second application targets natural terrain with manmade structures, using heavily compressed aerial video with a narrow field of view, and position and orientation data from the aircraft navigation system. In both applications, the translational and rotational offsets between the camera and inertial reference frames are initially unknown, and only a small fraction of the scene is visible in any one video frame. We start by estimating sparse structure and motion from 2D feature tracks using a Kalman filter and/or repeated, partial bundle adjustments requiring bounded time per video frame. The first application additionally incorporates a weak assumption of bounding perpendicular planes to minimize a tendency of the motion estimation to drift, while the second application requires tight integration of the navigational data to alleviate the poor conditioning caused by the narrow field of view. This is followed by dense structure recovery via graph-cut-based multi-view stereo, meshing, and optional mesh simplification. Finally, input images are texture-mapped onto the 3D surface for rendering. We show sample results from multiple, novel viewpoints.

  4. Mobile Robot Hierarchical Simultaneous Localization and Mapping Using Monocular Vision

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A hierarchical mobile robot simultaneous localization and mapping (SLAM) method that allows us to obtain accurate maps was presented. The local map level is composed of a set of local metric feature maps that are guaranteed to be statistically independent. The global level is a topological graph whose arcs are labeled with the relative location between local maps. An estimation of these relative locations is maintained with local map alignment algorithm, and more accurate estimation is calculated through a global minimization procedure using the loop closure constraint. The local map is built with Rao-Blackwellised particle filter (RBPF), where the particle filter is used to extending the path posterior by sampling new poses. The landmark position estimation and update is implemented through extended Kalman filter (EKF). Monocular vision mounted on the robot tracks the 3D natural point landmarks, which are structured with matching scale invariant feature transform (SIFT) feature pairs. The matching for multi-dimension SIFT features is implemented with a KD-tree in the time cost of O(lbN). Experiment results on Pioneer mobile robot in a real indoor environment show the superior performance of our proposed method.

  5. Surgical outcome in monocular elevation deficit: A retrospective interventional study

    Directory of Open Access Journals (Sweden)

    Bandyopadhyay Rakhi

    2008-01-01

    Full Text Available Background and Aim: Monocular elevation deficiency (MED is characterized by a unilateral defect in elevation, caused by paretic, restrictive or combined etiology. Treatment of this multifactorial entity is therefore varied. In this study, we performed different surgical procedures in patients of MED and evaluated their outcome, based on ocular alignment, improvement in elevation and binocular functions. Study Design: Retrospective interventional study. Materials and Methods: Twenty-eight patients were included in this study, from June 2003 to August 2006. Five patients underwent Knapp procedure, with or without horizontal squint surgery, 17 patients had inferior rectus recession, with or without horizontal squint surgery, three patients had combined inferior rectus recession and Knapp procedure and three patients had inferior rectus recession combined with contralateral superior rectus or inferior oblique surgery. The choice of procedure was based on the results of forced duction test (FDT. Results: Forced duction test was positive in 23 cases (82%. Twenty-four of 28 patients (86% were aligned to within 10 prism diopters. Elevation improved in 10 patients (36% from no elevation above primary position (-4 to only slight limitation of elevation (-1. Five patients had preoperative binocular vision and none gained it postoperatively. No significant postoperative complications or duction abnormalities were observed during the follow-up period. Conclusion: Management of MED depends upon selection of the correct surgical technique based on employing the results of FDT, for a satisfactory outcome.

  6. Eyegaze Detection from Monocular Camera Image for Eyegaze Communication System

    Science.gov (United States)

    Ohtera, Ryo; Horiuchi, Takahiko; Kotera, Hiroaki

    An eyegaze interface is one of the key technologies as an input device in the ubiquitous-computing society. In particular, an eyegaze communication system is very important and useful for severely handicapped users such as quadriplegic patients. Most of the conventional eyegaze tracking algorithms require specific light sources, equipment and devices. In this study, a simple eyegaze detection algorithm is proposed using a single monocular video camera. The proposed algorithm works under the condition of fixed head pose, but slight movement of the face is accepted. In our system, we assume that all users have the same eyeball size based on physiological eyeball models. However, we succeed to calibrate the physiologic movement of the eyeball center depending on the gazing direction by approximating it as a change in the eyeball radius. In the gaze detection stage, the iris is extracted from a captured face frame by using the Hough transform. Then, the eyegaze angle is derived by calculating the Euclidean distance of the iris centers between the extracted frame and a reference frame captured in the calibration process. We apply our system to an eyegaze communication interface, and verified the performance through key typing experiments with a visual keyboard on display.

  7. A switch from inter-ocular to inter-hemispheric suppression following monocular deprivation in the rat visual cortex

    NARCIS (Netherlands)

    Pietrasanta, M.; Restani, L.; Cerri, C.; Olcese, U.; Medini, P.; Caleo, M.

    2014-01-01

    Binocularity is a key property of primary visual cortex (V1) neurons that is widely used to study synaptic integration in the brain and plastic mechanisms following an altered visual experience. However, it is not clear how the inputs from the two eyes converge onto binocular neurons, and how their

  8. Enhanced monocular visual odometry integrated with laser distance meter for astronaut navigation.

    Science.gov (United States)

    Wu, Kai; Di, Kaichang; Sun, Xun; Wan, Wenhui; Liu, Zhaoqin

    2014-03-11

    Visual odometry provides astronauts with accurate knowledge of their position and orientation. Wearable astronaut navigation systems should be simple and compact. Therefore, monocular vision methods are preferred over stereo vision systems, commonly used in mobile robots. However, the projective nature of monocular visual odometry causes a scale ambiguity problem. In this paper, we focus on the integration of a monocular camera with a laser distance meter to solve this problem. The most remarkable advantage of the system is its ability to recover a global trajectory for monocular image sequences by incorporating direct distance measurements. First, we propose a robust and easy-to-use extrinsic calibration method between camera and laser distance meter. Second, we present a navigation scheme that fuses distance measurements with monocular sequences to correct the scale drift. In particular, we explain in detail how to match the projection of the invisible laser pointer on other frames. Our proposed integration architecture is examined using a live dataset collected in a simulated lunar surface environment. The experimental results demonstrate the feasibility and effectiveness of the proposed method.

  9. Dichoptic training in adults with amblyopia: Additional stereoacuity gains over monocular training.

    Science.gov (United States)

    Liu, Xiang-Yun; Zhang, Jun-Yun

    2017-08-04

    Dichoptic training is a recent focus of research on perceptual learning in adults with amblyopia, but whether and how dichoptic training is superior to traditional monocular training is unclear. Here we investigated whether dichoptic training could further boost visual acuity and stereoacuity in monocularly well-trained adult amblyopic participants. During dichoptic training the participants used the amblyopic eye to practice a contrast discrimination task, while a band-filtered noise masker was simultaneously presented in the non-amblyopic fellow eye. Dichoptic learning was indexed by the increase of maximal tolerable noise contrast for successful contrast discrimination in the amblyopic eye. The results showed that practice tripled maximal tolerable noise contrast in 13 monocularly well-trained amblyopic participants. Moreover, the training further improved stereoacuity by 27% beyond the 55% gain from previous monocular training, but unchanged visual acuity of the amblyopic eyes. Therefore our dichoptic training method may produce extra gains of stereoacuity, but not visual acuity, in adults with amblyopia after monocular training. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. MONOCULAR AND BINOCULAR VISION IN THE PERFORMANCE OF A COMPLEX SKILL

    Directory of Open Access Journals (Sweden)

    Thomas Heinen

    2011-09-01

    Full Text Available The goal of this study was to investigate the role of binocular and monocular vision in 16 gymnasts as they perform a handspring on vault. In particular we reasoned, if binocular visual information is eliminated while experts and apprentices perform a handspring on vault, and their performance level changes or is maintained, then such information must or must not be necessary for their best performance. If the elimination of binocular vision leads to differences in gaze behavior in either experts or apprentices, this would answer the question of an adaptive gaze behavior, and thus if this is a function of expertise level or not. Gaze behavior was measured using a portable and wireless eye-tracking system in combination with a movement-analysis system. Results revealed that gaze behavior differed between experts and apprentices in the binocular and monocular conditions. In particular, apprentices showed less fixations of longer duration in the monocular condition as compared to experts and the binocular condition. Apprentices showed longer blink duration than experts in both, the monocular and binocular conditions. Eliminating binocular vision led to a shorter repulsion phase and a longer second flight phase in apprentices. Experts exhibited no differences in phase durations between binocular and monocular conditions. Findings suggest, that experts may not rely on binocular vision when performing handsprings, and movement performance maybe influenced in apprentices when eliminating binocular vision. We conclude that knowledge about gaze-movement relationships may be beneficial for coaches when teaching the handspring on vault in gymnastics

  11. The precision of binocular and monocular depth judgments in natural settings.

    Science.gov (United States)

    McKee, Suzanne P; Taylor, Douglas G

    2010-08-01

    We measured binocular and monocular depth thresholds for objects presented in a real environment. Observers judged the depth separating a pair of metal rods presented either in relative isolation, or surrounded by other objects, including a textured surface. In the isolated setting, binocular thresholds were greatly superior to the monocular thresholds by as much as a factor of 18. The presence of adjacent objects and textures improved the monocular thresholds somewhat, but the superiority of binocular viewing remained substantial (roughly a factor of 10). To determine whether motion parallax would improve monocular sensitivity for the textured setting, we asked observers to move their heads laterally, so that the viewing eye was displaced by 8-10 cm; this motion produced little improvement in the monocular thresholds. We also compared disparity thresholds measured with the real rods to thresholds measured with virtual images in a standard mirror stereoscope. Surprisingly, for the two naive observers, the stereoscope thresholds were far worse than the thresholds for the real rods-a finding that indicates that stereoscope measurements for unpracticed observers should be treated with caution. With practice, the stereoscope thresholds for one observer improved to almost the precision of the thresholds for the real rods.

  12. Early maternal deprivation in rats: a proposed animal model for the study of developmental neuroimmunoendocrine interactions.

    Science.gov (United States)

    De la Fuente, M; Llorente, R; Baeza, I; De Castro, N M; Arranz, L; Cruces, J; Viveros, M P

    2009-02-01

    Adult animals that had been subjected to a single prolonged episode of maternal deprivation (MD) [24 h, postnatal day (PND) 9-10] show long-term behavioral alterations that resemble specific symptoms of schizophrenia. Moreover, at adolescence MD rats showed depressive-like behavior and altered motor responses. According to the neurodevelopmental hypothesis, certain behavioral abnormalities observed in MD animals may be related to altered neurodevelopmental processes triggered by MD-induced elevated glucocorticoids in relevant specific brain regions. We review here these neuroendocrine effects and show new data indicating that the MD procedure induces diverse detrimental effects on the immune system that are already revealed in the short term (PND 13) and persist into adulthood. These long-lasting effects might be related to altered hypothalamus-pituitary-adrenal axis activity and to social as well as nutrition-related factors. In fact, MD induces long-lasting decreases in body weight. In view of our findings we propose the present MD procedure as a potentially useful model to analyze developmental interactions between early psychophysiological stress and immunodeficient states.

  13. Patterns of non-embolic transient monocular visual field loss.

    Science.gov (United States)

    Petzold, Axel; Islam, Niaz; Plant, G T

    2013-07-01

    The aim of this study was to systematically describe the semiology of non-embolic transient monocular visual field loss (neTMVL). We conducted a retrospective case note analysis of patients from Moorfields Eye Hospital (1995-2007). The variables analysed were age, age of onset, gender, past medical history or family history of migraine, eye affected, onset, duration and offset, perception (pattern, positive and negative symptoms), associated headache and autonomic symptoms, attack frequency, and treatment response to nifedipine. We identified 77 patients (28 male and 49 female). Mean age of onset was 37 years (range 14-77 years). The neTMVL was limited to the right eye in 36 % to the left in 47 % and occurred independently in either eye in 5 % of cases. A past medical history of migraine was present in 12 % and a family history in 8 %. Headache followed neTMVL in 14 % and was associated with autonomic features in 3 %. The neTMB was perceived as grey in 35 %, white in 21 %, black in 16 % and as phosphenes in 9 %. Most frequently neTMVL was patchy 20 %. Recovery of vision frequently resembled attack onset in reverse. In 3 patients without associated headache the loss of vision was permanent. Treatment with nifedipine was initiated in 13 patients with an attack frequency of more than one per week and reduced the attack frequency in all. In conclusion, this large series of patients with neTMVL permits classification into five types of reversible visual field loss (grey, white, black, phosphenes, patchy). Treatment response to nifidipine suggests some attacks to be caused by vasospasm.

  14. Protection against deprivation amblyopia depends on relative not absolute daily binocular exposure.

    Science.gov (United States)

    Mitchell, Donald E; Sengpiel, Frank; Hamilton, David C; Schwarzkopf, D Samuel; Kennie, Jan

    2011-06-16

    Short daily periods of binocular exposure (BE) can offset longer single daily episodes of monocular exposure (ME) to prevent the development of deprivation amblyopia. To determine whether the outcome depended upon an absolute daily amount of BE or its proportion of the daily visual exposure, daily mixed visual input of 3 different durations (3.5, 7, or 12 h) was imposed on 3 cohorts of kittens. Measurements of the visual acuity of the deprived eye at the end of mixed daily visual input revealed that the acuity of the deprived eye developed to normal values so long as the proportion of the total exposure that was binocular was 30% or more. By contrast, the development of functional ocular dominance domains in V1 revealed by optical imaging suggests that normal domains emerge with a fixed amount of daily binocular exposure. The latter result is consistent with the effects of any daily period of ME, or BE, or both, effectively saturating with a small dose so that the effects of ME of any length can be offset by a short period of BE. The different result for vision may reflect neural events at higher and/or multiple levels in the visual pathway.

  15. The contribution of monocular depth cues to scene perception by pigeons.

    Science.gov (United States)

    Cavoto, Brian R; Cook, Robert G

    2006-07-01

    The contributions of different monocular depth cues to performance of a scene perception task were investigated in 4 pigeons. They discriminated the sequential depth ordering of three geometric objects in computer-rendered scenes. The orderings of these objects were specified by the combined presence or absence of the pictorial cues of relative density, occlusion, and relative size. In Phase 1, the pigeons learned the task as a direct function of the number of cues present. The three monocular cues contributed equally to the discrimination. Phase 2 established that differential shading on the objects provided an additional discriminative cue. These results suggest that the pigeon visual system is sensitive to many of the same monocular depth cues that are known to be used by humans. The theoretical implications for a comparative psychology of picture processing are considered.

  16. Refractive error and monocular viewing strengthen the hollow-face illusion.

    Science.gov (United States)

    Hill, Harold; Palmisano, Stephen; Matthews, Harold

    2012-01-01

    We measured the strength of the hollow-face illusion--the 'flipping distance' at which perception changes between convex and concave--as a function of a lens-induced 3 dioptre refractive error and monocular/binocular viewing. Refractive error and closing one eye both strengthened the illusion to approximately the same extent. The illusion was weakest viewed binocularly without refractive error and strongest viewed monocularly with it. This suggests binocular cues disambiguate the illusion at greater distances than monocular cues, but that both are disrupted by refractive error. We argue that refractive error leaves the ambiguous low-spatial-frequency shading information critical to the illusion largely unaffected while disrupting other, potentially disambiguating, depth/distance cues.

  17. A new combination of monocular and stereo cues for dense disparity estimation

    Science.gov (United States)

    Mao, Miao; Qin, Kaihuai

    2013-07-01

    Disparity estimation is a popular and important topic in computer vision and robotics. Stereo vision is commonly done to complete the task, but most existing methods fail in textureless regions and utilize numerical methods to interpolate into these regions. Monocular features are usually ignored, which may contain helpful depth information. We proposed a novel method combining monocular and stereo cues to compute dense disparities from a pair of images. The whole image regions are categorized into reliable regions (textured and unoccluded) and unreliable regions (textureless or occluded). Stable and accurate disparities can be gained at reliable regions. Then for unreliable regions, we utilize k-means to find the most similar reliable regions in terms of monocular cues. Our method is simple and effective. Experiments show that our method can generate a more accurate disparity map than existing methods from images with large textureless regions, e.g. snow, icebergs.

  18. Obituary of Philip H. Cooper, MD.

    Science.gov (United States)

    Patterson, James W; Wick, Mark R; Mills, Stacey E

    2015-08-01

    Dermatopathology lost a giant in the field with the death of Philip H. Cooper, MD, on Friday, January 30, 2015. The following obituary represents a celebration of his life and his contributions to our field.

  19. Differential processing of binocular and monocular gloss cues in human visual cortex

    Science.gov (United States)

    Di Luca, Massimiliano; Ban, Hiroshi; Muryy, Alexander; Fleming, Roland W.

    2016-01-01

    The visual impression of an object's surface reflectance (“gloss”) relies on a range of visual cues, both monocular and binocular. Whereas previous imaging work has identified processing within ventral visual areas as important for monocular cues, little is known about cortical areas involved in processing binocular cues. Here, we used human functional MRI (fMRI) to test for brain areas selectively involved in the processing of binocular cues. We manipulated stereoscopic information to create four conditions that differed in their disparity structure and in the impression of surface gloss that they evoked. We performed multivoxel pattern analysis to find areas whose fMRI responses allow classes of stimuli to be distinguished based on their depth structure vs. material appearance. We show that higher dorsal areas play a role in processing binocular gloss information, in addition to known ventral areas involved in material processing, with ventral area lateral occipital responding to both object shape and surface material properties. Moreover, we tested for similarities between the representation of gloss from binocular cues and monocular cues. Specifically, we tested for transfer in the decoding performance of an algorithm trained on glossy vs. matte objects defined by either binocular or by monocular cues. We found transfer effects from monocular to binocular cues in dorsal visual area V3B/kinetic occipital (KO), suggesting a shared representation of the two cues in this area. These results indicate the involvement of mid- to high-level visual circuitry in the estimation of surface material properties, with V3B/KO potentially playing a role in integrating monocular and binocular cues. PMID:26912596

  20. Differential processing of binocular and monocular gloss cues in human visual cortex.

    Science.gov (United States)

    Sun, Hua-Chun; Di Luca, Massimiliano; Ban, Hiroshi; Muryy, Alexander; Fleming, Roland W; Welchman, Andrew E

    2016-06-01

    The visual impression of an object's surface reflectance ("gloss") relies on a range of visual cues, both monocular and binocular. Whereas previous imaging work has identified processing within ventral visual areas as important for monocular cues, little is known about cortical areas involved in processing binocular cues. Here, we used human functional MRI (fMRI) to test for brain areas selectively involved in the processing of binocular cues. We manipulated stereoscopic information to create four conditions that differed in their disparity structure and in the impression of surface gloss that they evoked. We performed multivoxel pattern analysis to find areas whose fMRI responses allow classes of stimuli to be distinguished based on their depth structure vs. material appearance. We show that higher dorsal areas play a role in processing binocular gloss information, in addition to known ventral areas involved in material processing, with ventral area lateral occipital responding to both object shape and surface material properties. Moreover, we tested for similarities between the representation of gloss from binocular cues and monocular cues. Specifically, we tested for transfer in the decoding performance of an algorithm trained on glossy vs. matte objects defined by either binocular or by monocular cues. We found transfer effects from monocular to binocular cues in dorsal visual area V3B/kinetic occipital (KO), suggesting a shared representation of the two cues in this area. These results indicate the involvement of mid- to high-level visual circuitry in the estimation of surface material properties, with V3B/KO potentially playing a role in integrating monocular and binocular cues. Copyright © 2016 the American Physiological Society.

  1. Visibility of monocular symbology in transparent head-mounted display applications

    Science.gov (United States)

    Winterbottom, M.; Patterson, R.; Pierce, B.; Gaska, J.; Hadley, S.

    2015-05-01

    With increased reliance on head-mounted displays (HMDs), such as the Joint Helmet Mounted Cueing System and F-35 Helmet Mounted Display System, research concerning visual performance has also increased in importance. Although monocular HMDs have been used successfully for many years, a number of authors have reported significant problems with their use. Certain problems have been attributed to binocular rivalry when differing imagery is presented to the two eyes. With binocular rivalry, the visibility of the images in the two eyes fluctuates, with one eye's view becoming dominant, and thus visible, while the other eye's view is suppressed, which alternates over time. Rivalry is almost certainly created when viewing an occluding monocular HMD. For semi-transparent monocular HMDs, however, much of the scene is binocularly fused, with additional imagery superimposed in one eye. Binocular fusion is thought to prevent rivalry. The present study was designed to investigate differences in visibility between monocularly and binocularly presented symbology at varying levels of contrast and while viewing simulated flight over terrain at various speeds. Visibility was estimated by measuring the presentation time required to identify a test probe (tumbling E) embedded within other static symbology. Results indicated that there were large individual differences, but that performance decreased with decreased test probe contrast under monocular viewing relative to binocular viewing conditions. Rivalry suppression may reduce visibility of semi-transparent monocular HMD imagery. However, factors, such as contrast sensitivity, masking, and conditions such as monofixation, will be important to examine in future research concerning visibility of HMD imagery.

  2. Eye movements in chameleons are not truly independent - evidence from simultaneous monocular tracking of two targets.

    Science.gov (United States)

    Katz, Hadas Ketter; Lustig, Avichai; Lev-Ari, Tidhar; Nov, Yuval; Rivlin, Ehud; Katzir, Gadi

    2015-07-01

    Chameleons perform large-amplitude eye movements that are frequently referred to as independent, or disconjugate. When prey (an insect) is detected, the chameleon's eyes converge to view it binocularly and 'lock' in their sockets so that subsequent visual tracking is by head movements. However, the extent of the eyes' independence is unclear. For example, can a chameleon visually track two small targets simultaneously and monocularly, i.e. one with each eye? This is of special interest because eye movements in ectotherms and birds are frequently independent, with optic nerves that are fully decussated and intertectal connections that are not as developed as in mammals. Here, we demonstrate that chameleons presented with two small targets moving in opposite directions can perform simultaneous, smooth, monocular, visual tracking. To our knowledge, this is the first demonstration of such a capacity. The fine patterns of the eye movements in monocular tracking were composed of alternating, longer, 'smooth' phases and abrupt 'step' events, similar to smooth pursuits and saccades. Monocular tracking differed significantly from binocular tracking with respect to both 'smooth' phases and 'step' events. We suggest that in chameleons, eye movements are not simply 'independent'. Rather, at the gross level, eye movements are (i) disconjugate during scanning, (ii) conjugate during binocular tracking and (iii) disconjugate, but coordinated, during monocular tracking. At the fine level, eye movements are disconjugate in all cases. These results support the view that in vertebrates, basic monocular control is under a higher level of regulation that dictates the eyes' level of coordination according to context. © 2015. Published by The Company of Biologists Ltd.

  3. Sleep Deprivation and Neurobehavioral Dynamics

    OpenAIRE

    Basner, Mathias; Rao, Hengyi; Goel, Namni; David F. Dinges

    2013-01-01

    Lifestyles involving sleep deprivation are common, despite mounting evidence that both acute total sleep deprivation and chronically restricted sleep degrade neurobehavioral functions associated with arousal, attention, memory and state stability. Current research suggests dynamic differences in the way the central nervous system responds to acute versus chronic sleep restriction, which is reflected in new models of sleep-wake regulation. Chronic sleep restriction likely induces long-term neu...

  4. Induction of Monocular Stereopsis by Altering Focus Distance: A Test of Ames's Hypothesis.

    Science.gov (United States)

    Vishwanath, Dhanraj

    2016-03-01

    Viewing a real three-dimensional scene or a stereoscopic image with both eyes generates a vivid phenomenal impression of depth known as stereopsis. Numerous reports have highlighted the fact that an impression of stereopsis can be induced in the absence of binocular disparity. A method claimed by Ames (1925) involved altering accommodative (focus) distance while monocularly viewing a picture. This claim was tested on naïve observers using a method inspired by the observations of Gogel and Ogle on the equidistance tendency. Consistent with Ames's claim, most observers reported that the focus manipulation induced an impression of stereopsis comparable to that obtained by monocular-aperture viewing.

  5. Elimination of aniseikonia in monocular aphakia with a contact lens-spectacle combination.

    Science.gov (United States)

    Schechter, R J

    1978-01-01

    Correction of monocular aphakia with contact lenses generally results in aniseikonia in the range of 7--9%; with correction by intraocular lenses, aniseikonia is approximately 2%. We present a new method of correcting aniseikonia in monocular aphakics using a contact lens-spectacle combination. A formula is derived wherein the contact lens is deliberately overcorrected; this overcorrection is then neutralized by the appropriate spectacle lens, to be worn over the contact lens. Calculated results with this system over a wide range of possible situations consistently results in an aniseikonia of 0.1%.

  6. END-TO-END DEPTH FROM MOTION WITH STABILIZED MONOCULAR VIDEOS

    Directory of Open Access Journals (Sweden)

    C. Pinard

    2017-08-01

    Full Text Available We propose a depth map inference system from monocular videos based on a novel dataset for navigation that mimics aerial footage from gimbal stabilized monocular camera in rigid scenes. Unlike most navigation datasets, the lack of rotation implies an easier structure from motion problem which can be leveraged for different kinds of tasks such as depth inference and obstacle avoidance. We also propose an architecture for end-to-end depth inference with a fully convolutional network. Results show that although tied to camera inner parameters, the problem is locally solvable and leads to good quality depth prediction.

  7. Development of monocular and binocular multi-focus 3D display systems using LEDs

    Science.gov (United States)

    Kim, Sung-Kyu; Kim, Dong-Wook; Son, Jung-Young; Kwon, Yong-Moo

    2008-04-01

    Multi-focus 3D display systems are developed and a possibility about satisfaction of eye accommodation is tested. The multi-focus means the ability of monocular depth cue to various depth levels. By achieving the multi-focus function, we developed 3D display systems for one eye and both eyes, which can satisfy accommodation to displayed virtual objects within defined depth. The monocular accommodation and the binocular convergence 3D effect of the system are tested and a proof of the satisfaction of the accommodation and experimental result of the binocular 3D fusion are given as results by using the proposed 3D display systems.

  8. Selective Rapid Eye Movement Sleep Deprivation Affects Cell Size and Number in Kitten Locus Coeruleus

    Directory of Open Access Journals (Sweden)

    James P Shaffery

    2012-05-01

    Full Text Available Cells in the locus coeruleus (LC constitute the sole source of norepinephrine (NE in the brain, and change their discharge rates according to vigilance state. In addition to its well established role in vigilance, NE affects synaptic plasticity in the postnatal critical period (CP of development. One form of CP synaptic plasticity affected by NE results from monocular occlusion, which leads to physiological and cytoarchitectural alterations in central visual areas. Selective suppression of rapid eye movement sleep (REMS in the CP kitten enhances the central effects of monocular occlusion. The mechanisms responsible for heightened cortical plasticity following REMS deprivation (REMSD remain undetermined. One possible mediator of an increase in plasticity is continuous NE outflow, which presumably persists during extended periods of REMSD. Tyrosine hydroxylase (TH is the rate-limiting enzyme in the synthesis of NE and serves as a marker for NE-producing cells. We selectively suppressed REMS in kittens for one week during the CP. The number and size of LC cells expressing immunoreactivity to tyrosine hydroxylase (TH-ir was assessed in age-matched REMS-deprived (RD-, treatment-control (TXC-, and home cage-reared (HCC animals. Sleep amounts and slow wave activity (SWA were also examined relative to baseline. Time spent in REMS during the study was lower in RD compared to TXC animals, and RD kittens increased SWA delta power in the latter half of the REMSD period. The estimated total number of TH-ir cells in LC was significantly lower in the RD- than in the TXC kittens and numerically lower than in HCC animals. The size of LC cells expressing TH-ir was greatest in the HCC group. They were significantly larger than the cells in the RD kittens. These data are consistent with a possible reduction in NE in forebrain areas, including visual cortex, caused by one week of REMSD.

  9. Sex-dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour.

    Science.gov (United States)

    Llorente-Berzal, Alvaro; Fuentes, Sílvia; Gagliano, Humberto; López-Gallardo, Meritxell; Armario, Antonio; Viveros, María-Paz; Nadal, Roser

    2011-10-01

    Early life experiences such as maternal deprivation (MD) exert long-lasting changes in adult behaviour and reactivity to stressors. Adolescent exposure to cannabinoids is a predisposing factor in developing certain psychiatric disorders. Therefore, the combination of the two factors could exacerbate the negative consequences of each factor when evaluated at adulthood. The objective of this study was to investigate the long-term effects of early MD [24 hours at postnatal day (PND) 9] and/or an adolescent chronic treatment with the cannabinoid agonist CP-55,940 (0.4 mg/kg, PND 28-42) on diverse behavioural and physiological responses of adult male and female Wistar rats. We tested them in the prepulse inhibition (PPI) of the startle response and analysed their exploratory activity (holeboard) and anxiety (elevated plus maze, EPM). In addition, we evaluated their adrenocortical reactivity in response to stress and plasma leptin levels. Maternal behaviour was measured before and after deprivation. MD induced a transient increase of maternal behaviour on reuniting. In adulthood, maternally deprived males showed anxiolytic-like behaviour (or increased risk-taking behaviour) in the EPM. Adolescent exposure to the cannabinoid agonist induced an impairment of the PPI in females and increased adrenocortical responsiveness to the PPI test in males. Both, MD and adolescent cannabinoid exposure also induced sex-dependent changes in plasma leptin levels and body weights. The present results indicate that early MD and adolescent cannabinoid exposure exerted distinct sex-dependent long-term behavioural and physiological modifications that could predispose to the development of certain neuropsychiatric disorders, though no synergistic effects were found.

  10. Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: a possible role for the endocannabinoid system.

    Science.gov (United States)

    Llorente, Ricardo; Llorente-Berzal, Alvaro; Petrosino, Stefania; Marco, Eva-María; Guaza, Carmen; Prada, Carmen; López-Gallardo, Meritxell; Di Marzo, Vincenzo; Viveros, María-Paz

    2008-09-15

    Adult animals submitted to a single prolonged episode of maternal deprivation (MD) [24 h, postnatal days (PND) 9-10] show behavioral alterations that resemble specific symptoms of schizophrenia. These behavioral impairments may be related to neuronal loss in the hippocampus triggered by elevated glucocorticoids. Furthermore, our previous data suggested functional relationships between MD stress and the endocannabinoid system. In this study, we addressed the effects of MD on hippocampal glial cells and the possible relationship with changes in plasma corticosterone (CORT) levels. In addition, we investigated the putative involvement of the endocannabinoid system by evaluating (a) the effects of MD on hippocampal levels of endocannabinoids (b) The modulation of MD effects by two inhibitors of endocannabinoids inactivation, the fatty acid amide hydrolase inhibitor N-arachidonoyl-serotonin (AA-5-HT), and the endocannabinoid reuptake inhibitor, OMDM-2. Drug treatments were administered once daily from PND 7 to PND 12 at a dose of 5 mg/kg, and the animals were sacrificed at PND 13. MD induced increased CORT levels in both genders. MD males also showed an increased number of astrocytes in CA1 and CA3 areas and a significant increase in hippocampal 2-arachidonoylglycerol. The cannabinoid compounds reversed the endocrine and cellular effects of maternal deprivation. We provide direct evidence for gender-dependent cellular and biochemical effects of MD on developmental hippocampus, including changes in the endocannabinoid system.

  11. Stochastically optimized monocular vision-based navigation and guidance

    Science.gov (United States)

    Watanabe, Yoko

    The objective of this thesis is to design a relative navigation and guidance law for unmanned aerial vehicles, or UAVs, for vision-based control applications. The autonomous operation of UAVs has progressively developed in recent years. In particular, vision-based navigation, guidance and control has been one of the most focused on research topics for the automation of UAVs. This is because in nature, birds and insects use vision as the exclusive sensor for object detection and navigation. Furthermore, it is efficient to use a vision sensor since it is compact, light-weight and low cost. Therefore, this thesis studies the monocular vision-based navigation and guidance of UAVs. Since 2-D vision-based measurements are nonlinear with respect to the 3-D relative states, an extended Kalman filter (EKF) is applied in the navigation system design. The EKF-based navigation system is integrated with a real-time image processing algorithm and is tested in simulations and flight tests. The first closed-loop vision-based formation flight between two UAVs has been achieved, and the results are shown in this thesis to verify the estimation performance of the EKF. In addition, vision-based 3-D terrain recovery was performed in simulations to present a navigation design which has the capability of estimating states of multiple objects. In this problem, the statistical z-test is applied to solve the correspondence problem of relating measurements and estimation states. As a practical example of vision-based control applications for UAVs, a vision-based obstacle avoidance problem is specially addressed in this thesis. A navigation and guidance system is designed for a UAV to achieve a mission of waypoint tracking while avoiding unforeseen stationary obstacles by using vision information. An EKF is applied to estimate each obstacles' position from the vision-based information. A collision criteria is established by using a collision-cone approach and a time-to-go criterion. A minimum

  12. Monocular zones in stereoscopic scenes: A useful source of information for human binocular vision?

    Science.gov (United States)

    Harris, Julie M.

    2010-02-01

    When an object is closer to an observer than the background, the small differences between right and left eye views are interpreted by the human brain as depth. This basic ability of the human visual system, called stereopsis, lies at the core of all binocular three-dimensional (3-D) perception and related technological display development. To achieve stereopsis, it is traditionally assumed that corresponding locations in the right and left eye's views must first be matched, then the relative differences between right and left eye locations are used to calculate depth. But this is not the whole story. At every object-background boundary, there are regions of the background that only one eye can see because, in the other eye's view, the foreground object occludes that region of background. Such monocular zones do not have a corresponding match in the other eye's view and can thus cause problems for depth extraction algorithms. In this paper I will discuss evidence, from our knowledge of human visual perception, illustrating that monocular zones do not pose problems for our human visual systems, rather, our visual systems can extract depth from such zones. I review the relevant human perception literature in this area, and show some recent data aimed at quantifying the perception of depth from monocular zones. The paper finishes with a discussion of the potential importance of considering monocular zones, for stereo display technology and depth compression algorithms.

  13. Perception of Acceleration in Motion-In-Depth With Only Monocular and Binocular Information

    Directory of Open Access Journals (Sweden)

    Santiago Estaún

    2003-01-01

    Full Text Available Percepción de la aceleración en el movimiento en profundidad con información monocular y con información monocular y binocular. En muchas ocasiones es necesario adecuar nuestras acciones a objetos que cambian su aceleración. Sin embargo, no se ha encontrado evidencia de una percepción directa de la aceleración. En su lugar, parece ser que somos capaces de detectar cambios de velocidad en el movimiento 2-D dentro de una ventana temporal. Además, resultados recientes sugieren que el movimiento en profundidad se detecta a través de cambios de posición. Por lo tanto, para detectar aceleración en profundidad sería necesario que el sistema visual lleve a cabo algun tipo de cómputo de segundo orden. En dos experimentos, mostramos que los observadores no perciben la aceleración en trayectorias de aproximación, al menos en los rangos que utilizados [600- 800 ms] dando como resultado una sobreestimación del tiempo de llegada. Independientemente de la condición de visibilidad (sólo monocular o monocular más binocular, la respuesta se ajusta a una estrategia de velocidad constante. No obstante, la sobreestimación se reduce cuando la información binocular está disponible.

  14. Depth of Monocular Elements in a Binocular Scene: The Conditions for da Vinci Stereopsis

    Science.gov (United States)

    Cook, Michael; Gillam, Barbara

    2004-01-01

    Quantitative depth based on binocular resolution of visibility constraints is demonstrated in a novel stereogram representing an object, visible to 1 eye only, and seen through an aperture or camouflaged against a background. The monocular region in the display is attached to the binocular region, so that the stereogram represents an object which…

  15. Binocular and Monocular Depth Cues in Online Feedback Control of 3-D Pointing Movement

    Science.gov (United States)

    Hu, Bo; Knill, David C.

    2012-01-01

    Previous work has shown that humans continuously use visual feedback of the hand to control goal-directed movements online. In most studies, visual error signals were predominantly in the image plane and thus were available in an observer’s retinal image. We investigate how humans use visual feedback about finger depth provided by binocular and monocular depth cues to control pointing movements. When binocularly viewing a scene in which the hand movement was made in free space, subjects were about 60 ms slower in responding to perturbations in depth than in the image plane. When monocularly viewing a scene designed to maximize the available monocular cues to finger depth (motion, changing size and cast shadows), subjects showed no response to perturbations in depth. Thus, binocular cues from the finger are critical to effective online control of hand movements in depth. An optimal feedback controller that takes into account of the low peripheral stereoacuity and inherent ambiguity in cast shadows can explain the difference in response time in the binocular conditions and lack of response in monocular conditions. PMID:21724567

  16. Depth of Monocular Elements in a Binocular Scene: The Conditions for da Vinci Stereopsis

    Science.gov (United States)

    Cook, Michael; Gillam, Barbara

    2004-01-01

    Quantitative depth based on binocular resolution of visibility constraints is demonstrated in a novel stereogram representing an object, visible to 1 eye only, and seen through an aperture or camouflaged against a background. The monocular region in the display is attached to the binocular region, so that the stereogram represents an object which…

  17. LASIK monocular en pacientes adultos con ambliopía por anisometropía

    Directory of Open Access Journals (Sweden)

    Alejandro Tamez-Peña

    2017-09-01

    Conclusiones: La cirugía refractiva monocular en pacientes con ambliopía por anisometropía es una opción terapéutica segura y efectiva que ofrece resultados visuales satisfactorios, preservando o incluso mejorando la AVMC preoperatoria.

  18. Binocular and monocular depth cues in online feedback control of 3D pointing movement.

    Science.gov (United States)

    Hu, Bo; Knill, David C

    2011-06-30

    Previous work has shown that humans continuously use visual feedback of the hand to control goal-directed movements online. In most studies, visual error signals were predominantly in the image plane and, thus, were available in an observer's retinal image. We investigate how humans use visual feedback about finger depth provided by binocular and monocular depth cues to control pointing movements. When binocularly viewing a scene in which the hand movement was made in free space, subjects were about 60 ms slower in responding to perturbations in depth than in the image plane. When monocularly viewing a scene designed to maximize the available monocular cues to finger depth (motion, changing size, and cast shadows), subjects showed no response to perturbations in depth. Thus, binocular cues from the finger are critical to effective online control of hand movements in depth. An optimal feedback controller that takes into account the low peripheral stereoacuity and inherent ambiguity in cast shadows can explain the difference in response time in the binocular conditions and lack of response in monocular conditions.

  19. Depth scaling in phantom and monocular gap stereograms using absolute distance information.

    Science.gov (United States)

    Kuroki, Daiichiro; Nakamizo, Sachio

    2006-11-01

    The present study aimed to investigate whether the visual system scales apparent depth from binocularly unmatched features by using absolute distance information. In Experiment 1 we examined the effect of convergence on perceived depth in phantom stereograms [Gillam, B., & Nakayama, K. (1999). Quantitative depth for a phantom surface can be based on cyclopean occlusion cues alone. Vision Research, 39, 109-112.], monocular gap stereograms [Pianta, M. J., & Gillam, B. J. (2003a). Monocular gap stereopsis: manipulation of the outer edge disparity and the shape of the gap. Vision Research, 43, 1937-1950.] and random dot stereograms. In Experiments 2 and 3 we examined the effective range of viewing distances for scaling the apparent depths in these stereograms. The results showed that: (a) the magnitudes of perceived depths increased in all stereograms as the estimate of the viewing distance increased while keeping proximal and/or distal sizes of the stimuli constant, and (b) the effective range of viewing distances was significantly shorter in monocular gap stereograms. The first result indicates that the visual system scales apparent depth from unmatched features as well as that from horizontal disparity, while the second suggests that, at far distances, the strength of the depth signal from an unmatched feature in monocular gap stereograms is relatively weaker than that from horizontal disparity.

  20. MD5算法的分析和改进%Analysis and Improvement of .MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    么丽颖

    2011-01-01

    首先研究了MD5算法,并总结了MD5算法的特点及性能,在研究MD5算法的基础之上,提出了MD5改进加密算法.最后,对MD5算法与MD5改进算法对应于相关数据、性能进行了比较.%At first , MD5 algorithm is researched, and the characteristic and capability of the MD5 are summaried in the paper. The improved MD5 algorithm is put forward based on the research of the MDS. At last, the contrast between MD5 algorithm and the improved MD5 algorithm in related datum and capability are put forward.

  1. New Message Differences for Collision Attacks on MD4 and MD5

    Science.gov (United States)

    Sasaki, Yu; Wang, Lei; Kunihiro, Noboru; Ohta, Kazuo

    In 2005, collision resistance of several hash functions was broken by Wang et al. The strategy of determining message differences is the most important part of collision attacks against hash functions. So far, many researchers have tried to analyze Wang et al.'s method and proposed improved collision attacks. Although several researches proposed improved attacks, all improved results so far were based on the same message differences proposed by Wang et al. In this paper, we propose new message differences for collision attacks on MD4 and MD5. Our message differences of MD4 can generate a collision with complexity of less than two MD4 computations, which is faster than the original Wang et al.'s attack, and moreover, than the all previous attacks. This is the first result that improves the complexity of collision attack by using different message differences from Wang et al.'s. Regarding MD5, so far, no other message difference from Wang et al.'s is known. Therefore, study for constructing method of other message differences on MD5 should be interesting. Our message differences of MD5 generates a collision with complexity of 242 MD5 computations, which is slower than the latest best attack. However, since our attack needs only 1 bit difference, it has some advantages in terms of message freedom of collision messages.

  2. Sex-dependent alterations in response to maternal deprivation in rats.

    Science.gov (United States)

    Viveros, M P; Llorente, R; López-Gallardo, M; Suarez, J; Bermúdez-Silva, F; De la Fuente, M; Rodriguez de Fonseca, F; Garcia-Segura, L M

    2009-12-01

    We review here our latest results regarding short- and long-term effects of a neonatal maternal deprivation (MD) stress [24h at postnatal day (PND) 9] on diverse psychoneuroimmunoendocrine parameters, pointing out the existence of numerous sexual dimorphisms. Behavioral changes observed in MD animals might be at least in part attributable to neurodevelopmental effects of MD-induced elevated corticosterone levels. Our findings of short-term effects of MD on hippocampal and cerebellar neurons and glial cells appear to support this hypothesis. However, it is important to note that these cellular effects were more marked in males than in females. Moreover, in analyzing the effects of this neonatal stress on the endocannabinoid system (hippocampal endocannabinoid levels and CB1 receptors) we have also found that males were more affected by MD. Since all these sexual dimorphisms were found at an early neonatal age (PND 13), they are attributable to organizational effects of gonadal steroids. We discuss the potential implications of the elevated corticosterone and decreased leptin levels shown by MD animals in their diverse functional alterations, including the above mentioned neural effects as well as the intriguing persistent deficit in their immunological system. We also emphasize the necessity of analyzing the important influence of sex as regards the specific consequences of early life stress.

  3. Histone Deacetylase Inhibition Rescues Maternal Deprivation-Induced GABAergic Metaplasticity through Restoration of AKAP Signaling.

    Science.gov (United States)

    Authement, Michael E; Kodangattil, Jayaraj N; Gouty, Shawn; Rusnak, Milan; Symes, Aviva J; Cox, Brian M; Nugent, Fereshteh S

    2015-06-03

    Adverse early-life experiences such as child neglect and abuse increase the risk of developing addiction and stress-related disorders through alterations in motivational systems including the mesolimbic dopamine (DA) pathway. Here we investigated whether a severe early-life stress (i.e., maternal deprivation, MD) promotes DA dysregulation through an epigenetic impairment of synaptic plasticity within ventral tegmental area (VTA) DA neurons. Using a single 24-hr episode of MD and whole-cell patch clamp recording in rat midbrain slices, we show that MD selectively induces long-term depression (LTD) and shifts spike timing-dependent plasticity (STDP) toward LTD at GABAergic synapses onto VTA DA neurons through epigenetic modifications of postsynaptic scaffolding A-kinase anchoring protein 79/150 (AKAP79/150) signaling. Histone deacetylase (HDAC) inhibition rescues GABAergic metaplasticity and normalizes AKAP signaling in MD animals. MD-induced reversible HDAC-mediated GABAergic dysfunction within the VTA may be a mechanistic link for increased propensity to mental health disorders following MD. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Dopamine antagonists and brief vision distinguish lens-induced- and form-deprivation-induced myopia.

    Science.gov (United States)

    Nickla, Debora L; Totonelly, Kristen

    2011-11-01

    In eyes wearing negative lenses, the D2 dopamine antagonist spiperone was only partly effective in preventing the ameliorative effects of brief periods of vision (Nickla et al., 2010), in contrast to reports from studies using form-deprivation. The present study was done to directly compare the effects of spiperone, and the D1 antagonist SCH-23390, on the two different myopiagenic paradigms. 12-day old chickens wore monocular diffusers (form-deprivation) or -10 D lenses attached to the feathers with matching rings of Velcro. Each day for 4 days, 10 μl intravitreal injections of the dopamine D2/D4 antagonist spiperone (5 nmoles) or the D1 antagonist SCH-23390, were given under isoflurane anesthesia, and the diffusers (n = 16; n = 5, respectively) or lenses (n = 20; n = 6) were removed for 2 h immediately after. Saline injections prior to vision were done as controls (form-deprivation: n = 11; lenses: n = 10). Two other saline-injected groups wore the lenses (n = 12) or diffusers (n = 4) continuously. Axial dimensions were measured by high frequency A-scan ultrasonography at the start, and on the last day immediately prior to, and 3 h after the injection. Refractive errors were measured at the end of the experiment using a Hartinger's refractometer. In form-deprived eyes, spiperone, but not SCH-23390, prevented the ocular growth inhibition normally effected by the brief periods of vision (change in vitreous chamber depth, spiperone vs saline: 322 vs 211 μm; p = 0.01). By contrast, neither had any effect on negative lens-wearing eyes given similar unrestricted vision (210 and 234 μm respectively, vs 264 μm). The increased elongation in the spiperone-injected form-deprived eyes did not, however, result in a myopic shift, probably due to the inhibitory effect of the drug on anterior chamber growth (drug vs saline: 96 vs 160 μm; p < 0.01). Finally, spiperone inhibited the vision-induced transient choroidal thickening in form-deprived eyes, while SCH-23390 did not

  5. Effect of pirenzepine ophthalmic solution on form-deprivation myopia in the guinea pigs.

    Science.gov (United States)

    Le, Qi-hua; Cheng, Neng-neng; Wu, Wei; Chu, Ren-yuan

    2005-04-05

    Nonselective muscarinic receptor antagonist, atropine, was believed to inhibit myopic progression. The purpose of this study was to determine the efficacy, through topical administration, of the M1-selective muscarinic antagonist pirenzepine in preventing experimentally induced form-deprivation myopia in guinea pigs. Fifty-three guinea pigs, which underwent monocular deprivation with their eyelids sutured, were divided into 6 groups. Three groups were treated with 1%, 2% or 4% pirenzepine ophthalmic solutions; the fourth group with atropine; the fifth with saline and the last group left untreated. Ocular refraction, in vivo biometric measurements and wet eye weight were collected before and after the experiment. All the eyes were finally enucleated for histopathological examination to evaluate the possible toxic effects on ocular structures. Animals untreated or treated with saline produced (-2.31+/-1.47) D and (-2.25+/-0.88) D of axial myopia respectively. Those treated with 1% pirenzepine ophthalmic solution produced relative myopia of (-1.63+/-0.48) D, and those under the treatment of 2% and 4% pirenzepine ophthalmic solution only developed a relative myopia of (-0.89+/-0.42) D and (-0.70+/-0.41) D (F=9.56, Ppirenzepine treated animals was caused by significantly less vitreous chamber elongation and axial elongation of the deprived eyes [2% group: (0.009+/-0.052) mm, 4% group: (0.006+/-0.078) mm] when compared with untreated, saline treated or 1% pirenzepine treated guinea pigs (0.057+/-0.056) mm, (0.064+/-0.053) mm and (0.033+/-0.035) mm, respectively]. Histological examinations revealed no obviously toxic effects on the eyes treated with pirenzepine. Topical administration of the M1-selective muscarinic antagonist, pirenzepine, can prevent induced form-deprivation myopia in guinea pigs by inhibiting axial elongation without obvious damage to ocular tissues.

  6. Expression of pax-6 in rhesus monkey of optical defocus induced myopia and form deprivation myopia

    Institute of Scientific and Technical Information of China (English)

    钟兴武; 葛坚; 邓文国; 陈晓莲; 黄娟

    2004-01-01

    Background Pax-6 gene plays an important role in the process of eye development. This study was to determine the role of pax-6 in the axial myopia produced by hyperopic optical defocus and form deprivation in infant monkeys. Methods Among seven normal infant rhesus monkeys (aged 1 to 1.5 months), five wore -3.00 D spectacle lenses over their right eyes and zero-powered lenses over their left eyes. Monocular form deprivation was produced by eyelid fusion in two monkeys. Ten weeks later, the monkeys were sacrificed by an overdose of barbiturates and their eyes were removed immediately. A 5 mm×5 mm button of retina and sclera was taken from the posterior poles along with a 4-mm optic nerve. RNA was isolated separately from each of these three types of tissues. After that, reverse transcription polymerase chain reaction (RT-PCR) was used for determining gene expression in the retina, sclera and optic nerve. Semi-quantitative analyses were performed on the PCR products. Results As expected, the optically induced hyperopic defocus and the form deprivation produced myopic growth. For the lens-treatment monkeys, pax-6 gene expression in the retinas of the defocused eyes was significantly higher than in the retinas of the left eyes (t=5.703, P=0.005). However, there were no analogous significant differences between pax-6 expression in the scleras or the optic nerves. For the two form-deprived monkeys, there were no obvious differences in pax-6 gene expression in the retinas or the optic nerves. Conclusion The result that the expression of pax-6 was enhanced by hyperopic defocus in the infant monkey retina suggests that pax-6 may be involved in vision-dependent eye growth and emmetropization.

  7. SOCIODEMOGRAPHIC DOAMINS OF DEPRIVATION AND PRETERM BIRTH

    Science.gov (United States)

    Background. Neighborhood-level deprivation has long been associated with adverse outcomes, including preterm birth (PTB), as observed in the authors' previous work using a composite deprivation index. Area disadvantage is multifaceted comprising income, employment, education and...

  8. SOCIODEMOGRAPHIC DOAMINS OF DEPRIVATION AND PRETERM BIRTH

    Science.gov (United States)

    Background. Neighborhood-level deprivation has long been associated with adverse outcomes, including preterm birth (PTB), as observed in the authors' previous work using a composite deprivation index. Area disadvantage is multifaceted comprising income, employment, education and...

  9. PHYSIOLOGICAL RESPONSES OF MEN DURING SLEEP DEPRIVATION,

    Science.gov (United States)

    The effects of 84 hours of sleep deprivation were examined in a group of six young men and compared with a group of six controls. Subjects were... sleep deprivation , physiological regulating systems are relatively unaffected by sleep loss. (Author)

  10. Prenatal nicotine and maternal deprivation stress de-regulate the development of CA1, CA3, and dentate gyrus neurons in hippocampus of infant rats.

    Directory of Open Access Journals (Sweden)

    Hong Wang

    Full Text Available Adverse experiences by the developing fetus and in early childhood are associated with profound effects on learning, emotional behavior, and cognition as a whole. In this study we investigated the effects of prenatal nicotine exposure (NIC, postnatal maternal deprivation (MD or the combination of the two (NIC+MD to determine if hippocampal neuron development is modulated by exposure to drugs of abuse and/or stress. Growth of rat offspring exposed to MD alone or NIC+MD was repressed until after weaning. In CA1 but not CA3 of postnatal day 14 (P14 pups, MD increased pyramidal neurons, however, in dentate gyrus (DG, decreased granule neurons. NIC had no effect on neuron number in CA1, CA3 or DG. Unexpectedly, NIC plus MD combined caused a synergistic increase in the number of CA1 or CA3 neurons. Neuron density in CA regions was unaffected by treatment, but in the DG, granule neurons had a looser packing density after NIC, MD or NIC+MD exposure. When septotemporal axes were analyzed, the synergism of stress and drug exposure in CA1 and CA3 was associated with rostral, whereas MD effects were predominantly associated with caudal neurons. TUNEL labeling suggests no active apoptosis at P14, and doublecortin positive neurons and mossy fibers were diminished in NIC+MD relative to controls. The laterality of the effect of nicotine and/or maternal deprivation in right versus left hippocampus was also analyzed and found to be insiginificant. We report for the first time that early life stressors such as postnatal MD and prenatal NIC exposure, when combined, may exhibit synergistic consequences for CA1 and CA3 pyramidal neuron development, and a potential antagonistic influence on developing DG neurons. These results suggest that early stressors may modulate neurogenesis, apoptosis, or maturation of glutamatergic neurons in the hippocampus in a region-specific manner during critical periods of neurodevelopment.

  11. 76 FR 77579 - Maryland Disaster #MD-00017

    Science.gov (United States)

    2011-12-13

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster MD-00017 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409...

  12. 78 FR 2707 - Maryland Disaster # MD-00026

    Science.gov (United States)

    2013-01-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster MD-00026 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409...

  13. Infantile nystagmus and visual deprivation

    DEFF Research Database (Denmark)

    Fledelius, Hans C; Jensen, Hanne

    2014-01-01

    PURPOSE: To evaluate whether effects of early foveal motor instability due to infantile nystagmus might compare to those of experimental visual deprivation on refraction in a childhood series. METHODS: This was a retrospective analysis of data from the Danish Register for Blind and Weaksighted Ch...

  14. Multidimensional child deprivation in Iran

    NARCIS (Netherlands)

    Yousefzadeh Faal Daghati, Sepideh; Mideros-Mora, Andrés; De Neubourg, Chris; Minujin, Alberto; Nandy, Shailen

    2012-01-01

    The chapter analyses children's multidimensional deprivation in Iran in 2009 and explores inequalities in different regions. The study focused on outcome indicators, with the level of analysis focusing on the individual child as well as the household. A child rights approach is applied to define dim

  15. Cataract surgery: emotional reactions of patients with monocular versus binocular vision Cirurgia de catarata: aspectos emocionais de pacientes com visão monocular versus binocular

    Directory of Open Access Journals (Sweden)

    Roberta Ferrari Marback

    2012-12-01

    Full Text Available PURPOSE: To analyze emotional reactions related to cataract surgery in two groups of patients (monocular vision - Group 1; binocular vision - Group 2. METHODS: A transversal comparative study was performed using a structured questionnaire from a previous exploratory study before cataract surgery. RESULTS: 206 patients were enrolled in the study, 96 individuals in Group 1 (69.3 ± 10.4 years and 110 in Group 2 (68.2 ± 10.2 years. Most patients in group 1 (40.6% and 22.7% of group 2, reported fear of surgery (pOBJETIVO: Verificar reações emocionais relacionadas à cirurgia de catarata entre pacientes com visão monocular (Grupo 1 e binocular (Grupo 2. MÉTODOS: Foi realizado um estudo tranversal, comparativo por meio de um questionário estruturado respondido por pacientes antes da cirurgia de catarata. RESULTADOS: A amostra foi composta de 96 pacientes no Grupo 1 (69.3 ± 10.4 anos e 110 no Grupo 2 (68.2 ± 10.2 anos. Consideravam apresentar medo da cirugia 40.6% do Grupo 1 e 22.7% do Grupo 2 (p<0.001 e entre as principais causas do medo, a possibilidade de perda da visão, complicações cirúrgicas e a morte durante o procedimento foram apontadas. Os sentimentos mais comuns entre os dois grupos foram dúvidas a cerca dos resultados da cirurgia e o nervosismo diante do procedimento. CONCLUSÃO: Pacientes com visão monocular apresentaram mais medo e dúvidas relacionadas à cirurgia de catarata comparados com aqueles com visão binocular. Portanto, é necessário que os médicos considerem estas reações emocionais e invistam mais tempo para esclarecer os riscos e benefícios da cirurgia de catarata.

  16. Cirurgia monocular para esotropias de grande ângulo: histórico e novos paradigmas Monocular surgery for large-angle esotropias: review and new paradigms

    Directory of Open Access Journals (Sweden)

    Edmilson Gigante

    2010-08-01

    Full Text Available As primitivas cirurgias de estrabismo, as miotomias e as tenotomias, eram feitas, simplesmente, seccionando-se o músculo ou o seu tendão, sem nenhuma sutura. Estas cirurgias eram feitas, geralmente, em um só olho, tanto em pequenos como em grandes desvios e os resultados eram pouco previsíveis. Jameson, em 1922, propôs uma nova técnica cirúrgica, usando suturas e fixando, na esclera, o músculo seccionado, tornando a cirurgia mais previsível. Para as esotropias, praticou recuos de, no máximo, 5 mm para o reto medial, o que se tornou uma regra para os demais cirurgiões que o sucederam, sendo impossível, a partir daí, a correção de esotropias de grande ângulo com cirurgia monocular. Rodriguez-Vásquez, em 1974, superou o parâmetro de 5 mm, propondo amplos recuos dos retos mediais (6 a 9 mm para o tratamento da síndrome de Ciancia, com bons resultados. Os autores revisaram a literatura, ano a ano, objetivando comparar os vários trabalhos e, com isso, concluíram que a cirurgia monocular de recuo-ressecção pode constituir uma opção viável para o tratamento cirúrgico das esotropias de grande ângulo.The primitive strabismus surgeries, myotomies and tenotomies, were performed simply by sectioning the muscle or its tendon without any suture. Such surgeries were usually performed in just one eye both in small and in large angles with not really predictable results. In 1922, Jameson introduced a new surgery technique using sutures and fixing the sectioned muscle to the sclera, increasing surgery predictability. For the esotropias he carried out no more than 5 mm recession of the medial rectus, which became a rule for the surgeons who followed him, which made it impossible from then on to correct largeangle esotropias with a monocular surgery. Rodriguez-Vásquez, in 1974, exceeded the 5 mm parameter by proposing large recessions of the medial recti (6 to 9 mm to treat the Ciancia syndrome with good results. The authors revised the

  17. Exploring intentions of physician-scientist trainees: factors influencing MD and MD/PhD interest in research careers.

    Science.gov (United States)

    Kwan, Jennifer M; Daye, Dania; Schmidt, Mary Lou; Conlon, Claudia Morrissey; Kim, Hajwa; Gaonkar, Bilwaj; Payne, Aimee S; Riddle, Megan; Madera, Sharline; Adami, Alexander J; Winter, Kate Quinn

    2017-07-11

    Prior studies have described the career paths of physician-scientist candidates after graduation, but the factors that influence career choices at the candidate stage remain unclear. Additionally, previous work has focused on MD/PhDs, despite many physician-scientists being MDs. This study sought to identify career sector intentions, important factors in career selection, and experienced and predicted obstacles to career success that influence the career choices of MD candidates, MD candidates with research-intense career intentions (MD-RI), and MD/PhD candidates. A 70-question survey was administered to students at 5 academic medical centers with Medical Scientist Training Programs (MSTPs) and Clinical and Translational Science Awards (CTSA) from the NIH. Data were analyzed using bivariate or multivariate analyses. More MD/PhD and MD-RI candidates anticipated or had experienced obstacles related to balancing academic and family responsibilities and to balancing clinical, research, and education responsibilities, whereas more MD candidates indicated experienced and predicted obstacles related to loan repayment. MD/PhD candidates expressed higher interest in basic and translational research compared to MD-RI candidates, who indicated more interest in clinical research. Overall, MD-RI candidates displayed a profile distinct from both MD/PhD and MD candidates. MD/PhD and MD-RI candidates experience obstacles that influence their intentions to pursue academic medical careers from the earliest training stage, obstacles which differ from those of their MD peers. The differences between the aspirations of and challenges facing MD, MD-RI and MD/PhD candidates present opportunities for training programs to target curricula and support services to ensure the career development of successful physician-scientists.

  18. Materialistic Cues Boosts Personal Relative Deprivation

    Directory of Open Access Journals (Sweden)

    Hong Zhang

    2016-08-01

    Full Text Available Three studies investigated whether exposure to materialistic cues would increase perceptions of personal relative deprivation and related emotional reactions. In Study 1, individuals who were surveyed in front of a luxury store reported higher levels of personal relative deprivation than those surveyed in front of an ordinary building. In Study 2, participants who viewed pictures of luxurious goods experienced greater personal relative deprivation than those viewed pictures of neutral scenes. Study 3 replicated the results from Study 2, with a larger sample size and a more refined assessment of relative deprivation. Implications of these findings for future studies on relative deprivation and materialism are discussed.

  19. Materialistic Cues Boosts Personal Relative Deprivation.

    Science.gov (United States)

    Zhang, Hong; Zhang, Wen

    2016-01-01

    Three studies investigated whether exposure to materialistic cues would increase perceptions of personal relative deprivation and related emotional reactions. In Study 1, individuals who were surveyed in front of a luxury store reported higher levels of personal relative deprivation than those surveyed in front of an ordinary building. In Study 2, participants who viewed pictures of luxurious goods experienced greater personal relative deprivation than those viewed pictures of neutral scenes. Study 3 replicated the results from Study 2, with a larger sample size and a more refined assessment of relative deprivation. Implications of these findings for future studies on relative deprivation and materialism are discussed.

  20. Evaluación de la reproducibilidad de la retinoscopia dinámica monocular de Merchán

    Directory of Open Access Journals (Sweden)

    Lizbeth Acuña

    2010-08-01

    Full Text Available Objetivo: Evaluar la reproducibilidad de la retinoscopia dinámica monocular y su nivel de acuerdo con la retinoscopia estática binocular y monocular, retinoscopia de Nott y Método Estimado Monocular (MEM. Métodos: Se determinó la reproducibilidad entre los evaluadores y entre los métodos por medio del coeficiente de correlación intraclase (CCI y se establecieron los límites de acuerdo de Bland y Altman. Resultados: Se evaluaron 126 personas entre 5 y 39 años y se encontró una baja reproducibilidad interexaminador de la retinoscopia dinámica monocular en ambos ojos CCI ojo derecho: 0.49 (IC95% 0.36; 0.51; ojo izquierdo 0.51 (IC95% 0.38; 0.59. El límite de acuerdo entre evaluadores fue ±1.25 D. Al evaluar la reproducibilidad entre la retinoscopia dinámica monocular y la estática se observó que la mayor reproducibilidad se obtuvo con la estática binocular y monocular y, en visión próxima, entre el método estimado monocular y la retinoscopia de Nott. Conclusiones: La retinoscopia dinámica monocular no es una prueba reproducible y presenta diferencias clínicas significativas para determinar el estado refractivo, en cuanto a poder dióptrico y tipo de ametropía, por tanto, no se puede considerar dentro de la batería de exámenes aplicados para determinar diagnósticos y correcciones refractivas tanto en la visión lejana como en la visión próxima.

  1. Evaluación de la reproducibilidad de la retinoscopia dinámica monocular de Merchán

    Directory of Open Access Journals (Sweden)

    Lizbeth Acuña

    2009-12-01

    Full Text Available Objetivo: Evaluar la reproducibilidad de la retinoscopia dinámica monocular y su nivel de acuerdo con la retinoscopia estática binocular y monocular, retinoscopia de Nott y Método Estimado Monocular (MEM.Métodos: Se determinó la reproducibilidad entre los evaluadores y entre los métodos por medio del coeficiente de correlación intraclase (CCI y se establecieron los límites de acuerdo de Bland y Altman.Resultados: Se evaluaron 126 personas entre 5 y 39 años y se encontró una baja reproducibilidad interexaminador de la retinoscopia dinámica monocular en ambos ojos CCI ojo derecho: 0.49 (IC95% 0.36; 0.51; ojo izquierdo 0.51 (IC95% 0.38; 0.59. El límite de acuerdo entre evaluadores fue ±1.25 D. Al evaluar la reproducibilidad entre la retinoscopia dinámica monocular y la estática se observó que la mayor reproducibilidad se obtuvo con la estática binocular y monocular y, en visión próxima, entre el método estimado monocular y la retinoscopia de Nott.Conclusiones: La retinoscopia dinámica monocular no es una prueba reproducible y presenta diferencias clínicas significativas para determinar el estado refractivo, en cuanto a poder dióptrico y tipo de ametropía, por tanto, no se puede considerar dentro de la batería de exámenes aplicados para determinar diagnósticos y correcciones refractivas tanto en la visión lejana como en la visión próxima.

  2. Comparison of form-deprived myopia and lens-induced myopia in guinea pigs

    Directory of Open Access Journals (Sweden)

    Hui Xiao

    2014-04-01

    Full Text Available AIM: To study the efficacy difference between form-deprived myopia (FDM and lens-induced myopia (LIM, the degree of myopia, axial length and pathological changes of the posterior sclera from guinea pigs were evaluated.METHODS: Four-week pigmented guinea pigs were randomly assigned into 3 groups, including normal control (n=6, FDM group with monocular cover (n=11 and LIM group with monocular -7D lens treatment (n=11. FDM group was form-deprived while LIM group was lens-induced for 14 d. Refractive error and axial length were measured prior to and post treatment, respectively. Morphological changes of sclera were examined using both light and electronic microscopes.RESULTS: After 14d treatment, refractive errors for FDM group and LIM group were -3.05±0.71D and -2.12±1.29D, respectively, which were significantly more myopic than that of normal controls and fellow control eyes (P<0.01. As for axial length, it was 7.93±0.03 mm for FDM group and 7.89±0.06 mm for LIM group, which were significantly longer than both normal and fellow controls (P<0.01. With respect to both refractory error and axial length, the differences between FDM group and LIM group were not significant (P>0.05. Under light microscope, both FDM group and LIM group showed thinned sclera, disarrangement of fibrosis and enlarged disassociation between fibers. Consistently, ultrastructural examination showed degenerated fibroblasts and thinned fibers in posterior sclera.CONCLUSION:Following two weeks of myopia induction in guinea pigs, with regard to the degree of myopia, axial length and pathological alterations, there was no significant difference between FDM and LIM models. Therefore, FDM and LIM are equally effective and useful as a model of experimental myopia and guinea pigs are ideal animals for induction of experimental myopia because their high sensitivity to both form-deprivation and lens-induction.

  3. Induction of Monocular Stereopsis by Altering Focus Distance: A Test of Ames’s Hypothesis

    Directory of Open Access Journals (Sweden)

    Dhanraj Vishwanath

    2016-04-01

    Full Text Available Viewing a real three-dimensional scene or a stereoscopic image with both eyes generates a vivid phenomenal impression of depth known as stereopsis. Numerous reports have highlighted the fact that an impression of stereopsis can be induced in the absence of binocular disparity. A method claimed by Ames (1925 involved altering accommodative (focus distance while monocularly viewing a picture. This claim was tested on naïve observers using a method inspired by the observations of Gogel and Ogle on the equidistance tendency. Consistent with Ames’s claim, most observers reported that the focus manipulation induced an impression of stereopsis comparable to that obtained by monocular-aperture viewing.

  4. Embolic and nonembolic transient monocular visual field loss: a clinicopathologic review.

    Science.gov (United States)

    Petzold, Axel; Islam, Niaz; Hu, Han-Hwa; Plant, Gordon T

    2013-01-01

    Transient monocular blindness and amaurosis fugax are umbrella terms describing a range of patterns of transient monocular visual field loss (TMVL). The incidence rises from ≈1.5/100,000 in the third decade of life to ≈32/100,000 in the seventh decade of life. We review the vascular supply of the retina that provides an anatomical basis for the types of TMVL and discuss the importance of collaterals between the external and internal carotid artery territories and related blood flow phenomena. Next, we address the semiology of TMVL, focusing on onset, pattern, trigger factors, duration, recovery, frequency-associated features such as headaches, and on tests that help with the important differential between embolic and non-embolic etiologies.

  5. A monocular vision system based on cooperative targets detection for aircraft pose measurement

    Science.gov (United States)

    Wang, Zhenyu; Wang, Yanyun; Cheng, Wei; Chen, Tao; Zhou, Hui

    2017-08-01

    In this paper, a monocular vision measurement system based on cooperative targets detection is proposed, which can capture the three-dimensional information of objects by recognizing the checkerboard target and calculating of the feature points. The aircraft pose measurement is an important problem for aircraft’s monitoring and control. Monocular vision system has a good performance in the range of meter. This paper proposes an algorithm based on coplanar rectangular feature to determine the unique solution of distance and angle. A continuous frame detection method is presented to solve the problem of corners’ transition caused by symmetry of the targets. Besides, a displacement table test system based on three-dimensional precision and measurement system human-computer interaction software has been built. Experiment result shows that it has a precision of 2mm in the range of 300mm to 1000mm, which can meet the requirement of the position measurement in the aircraft cabin.

  6. Monocular trajectory intersection method for 3D motion measurement of a point target

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    This article proposes a monocular trajectory intersection method,a videometrics measurement with a mature theoretical system to solve the 3D motion parameters of a point target.It determines the target’s motion parameters including its 3D trajectory and velocity by intersecting the parametric trajectory of a motion target and series of sight-rays by which a motion camera observes the target,in contrast with the regular intersection method for 3D measurement by which the sight-rays intersect at one point.The method offers an approach to overcome the technical failure of traditional monocular measurements for the 3D motion of a point target and thus extends the application fields of photogrammetry and computer vision.Wide application is expected in passive observations of motion targets on various mobile beds.

  7. A Novel Ship-Bridge Collision Avoidance System Based on Monocular Computer Vision

    Directory of Open Access Journals (Sweden)

    Yuanzhou Zheng

    2013-06-01

    Full Text Available The study aims to investigate the ship-bridge collision avoidance. A novel system for ship-bridge collision avoidance based on monocular computer vision is proposed in this study. In the new system, the moving ships are firstly captured by the video sequences. Then the detection and tracking of the moving objects have been done to identify the regions in the scene that correspond to the video sequences. Secondly, the quantity description of the dynamic states of the moving objects in the geographical coordinate system, including the location, velocity, orientation, etc, has been calculated based on the monocular vision geometry. Finally, the collision risk is evaluated and consequently the ship manipulation commands are suggested, aiming to avoid the potential collision. Both computer simulation and field experiments have been implemented to validate the proposed system. The analysis results have shown the effectiveness of the proposed system.

  8. Depth measurement using monocular stereo vision system: aspect of spatial discretization

    Science.gov (United States)

    Xu, Zheng; Li, Chengjin; Zhao, Xunjie; Chen, Jiabo

    2010-11-01

    The monocular stereo vision system, consisting of single camera with controllable focal length, can be used in 3D reconstruction. Applying the system for 3D reconstruction, must consider effects caused by digital camera. There are two possible methods to make the monocular stereo vision system. First one the distance between the target object and the camera image plane is constant and lens moves. The second method assumes that the lens position is constant and the image plane moves in respect to the target. In this paper mathematical modeling of two approaches is presented. We focus on iso-disparity surfaces to define the discretization effect on the reconstructed space. These models are implemented and simulated on Matlab. The analysis is used to define application constrains and limitations of these methods. The results can be also used to enhance the accuracy of depth measurement.

  9. Monocular trajectory intersection method for 3D motion measurement of a point target

    Institute of Scientific and Technical Information of China (English)

    YU QiFeng; SHANG Yang; ZHOU Jian; ZHANG XiaoHu; LI LiChun

    2009-01-01

    This article proposes a monocular trajectory intersection method,a videometrics measurement with a mature theoretical system to solve the 3D motion parameters of a point target.It determines the target's motion parameters including its 3D trajectory and velocity by intersecting the parametric trajectory of a motion target and series of sight-rays by which a motion camera observes the target,in contrast with the regular intersection method for 3D measurement by which the sight-rays intersect at one point.The method offers an approach to overcome the technical failure of traditional monocular measurements for the 3D motion of a point target and thus extends the application fields of photogrammetry and computer vision.Wide application is expected in passive observations of motion targets on various mobile beds.

  10. Large-scale monocular FastSLAM2.0 acceleration on an embedded heterogeneous architecture

    Science.gov (United States)

    Abouzahir, Mohamed; Elouardi, Abdelhafid; Bouaziz, Samir; Latif, Rachid; Tajer, Abdelouahed

    2016-12-01

    Simultaneous localization and mapping (SLAM) is widely used in many robotic applications and autonomous navigation. This paper presents a study of FastSLAM2.0 computational complexity based on a monocular vision system. The algorithm is intended to operate with many particles in a large-scale environment. FastSLAM2.0 was partitioned into functional blocks allowing a hardware software matching on a CPU-GPGPU-based SoC architecture. Performances in terms of processing time and localization accuracy were evaluated using a real indoor dataset. Results demonstrate that an optimized and efficient CPU-GPGPU partitioning allows performing accurate localization results and high-speed execution of a monocular FastSLAM2.0-based embedded system operating under real-time constraints.

  11. Batch By Batch Longitudinal Emittance Blowup MD

    CERN Document Server

    Mastoridis, T; Butterworth, A; Jaussi, M; Molendijk, J

    2012-01-01

    The transverse bunch emittance increases significantly at 450 GeV from the time of injection till the ramp due to IBS. By selectively blowing up the longitudinal emittance of the incoming batch at each injection, it should be possible to reduce the transverse emittance growth rates due to IBS. An MD was conducted on April 22nd 2012 to test the feasibility and performance of the batch-by-batch longitudinal emittance blowup. There were three main goals during the MD. First, to test the developed hardware, firmware, and software for the batch-by-batch blowup. Then, to measure the transverse emittance growth rates of blown-up and "witness" batches to quantify any improvement, and finally to test the ALLInjectSequencer class, which deals with the complicated gymnastics of introducing or masking the new batch to various RF loops.

  12. Direct NOE simulation from long MD trajectories

    Science.gov (United States)

    Chalmers, G.; Glushka, J. N.; Foley, B. L.; Woods, R. J.; Prestegard, J. H.

    2016-04-01

    A software package, MD2NOE, is presented which calculates Nuclear Overhauser Effect (NOE) build-up curves directly from molecular dynamics (MD) trajectories. It differs from traditional approaches in that it calculates correlation functions directly from the trajectory instead of extracting inverse sixth power distance terms as an intermediate step in calculating NOEs. This is particularly important for molecules that sample conformational states on a timescale similar to molecular reorientation. The package is tested on sucrose and results are shown to differ in small but significant ways from those calculated using an inverse sixth power assumption. Results are also compared to experiment and found to be in reasonable agreement despite an expected underestimation of water viscosity by the water model selected.

  13. MD on UFOs at MKIs and MKQs

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

    2012-01-01

    UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

  14. MD5的Keygenme分析

    Institute of Scientific and Technical Information of China (English)

    Firebig

    2006-01-01

    闲来无事,抓出个不知何时下的Keygenme练练手,分析后可知.这个Keygenme有2张数据表,由注册名经MD5运算后进行查表,得出2个DWORD数据.然后再由注册码经过一个可逆循环得出2个DWORD数据.最后对比是否正确。(MD5的具体介绍黑防6期有说明)

  15. Classical MD calculations with parallel computers

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Mitsuhiro [Nagoya Univ. (Japan)

    1998-03-01

    We have developed parallel computation codes for a classical molecular dynamics (MD) method. In order to use them on work station clusters as well as parallel super computers, we use MPI (message passing interface) library for distributed-memory type computers. Two algorithms are compared: (1) particle parallelism technique: easy to install, effective for rather small number of processors. (2) region parallelism technique: take some time to install, effective even for many nodes. (J.P.N.)

  16. Early Maternal Deprivation Enhances Voluntary Alcohol Intake Induced by Exposure to Stressful Events Later in Life

    Directory of Open Access Journals (Sweden)

    Sara Peñasco

    2015-01-01

    Full Text Available In the present study, we aimed to assess the impact of early life stress, in the form of early maternal deprivation (MD, 24 h on postnatal day, pnd, 9, on voluntary alcohol intake in adolescent male and female Wistar rats. During adolescence, from pnd 28 to pnd 50, voluntary ethanol intake (20%, v/v was investigated using the two-bottle free choice paradigm. To better understand the relationship between stress and alcohol consumption, voluntary alcohol intake was also evaluated following additional stressful events later in life, that is, a week of alcohol cessation and a week of alcohol cessation combined with exposure to restraint stress. Female animals consumed more alcohol than males only after a second episode of alcohol cessation combined with restraint stress. MD did not affect baseline voluntary alcohol intake but increased voluntary alcohol intake after stress exposure, indicating that MD may render animals more vulnerable to the effects of stress on alcohol intake. During adolescence, when animals had free access to alcohol, MD animals showed lower body weight gain but a higher growth rate than control animals. Moreover, the higher growth rate was accompanied by a decrease in food intake, suggesting an altered metabolic regulation in MD animals that may interact with alcohol intake.

  17. Early maternal deprivation enhances voluntary alcohol intake induced by exposure to stressful events later in life.

    Science.gov (United States)

    Peñasco, Sara; Mela, Virginia; López-Moreno, Jose Antonio; Viveros, María-Paz; Marco, Eva M

    2015-01-01

    In the present study, we aimed to assess the impact of early life stress, in the form of early maternal deprivation (MD, 24 h on postnatal day, pnd, 9), on voluntary alcohol intake in adolescent male and female Wistar rats. During adolescence, from pnd 28 to pnd 50, voluntary ethanol intake (20%, v/v) was investigated using the two-bottle free choice paradigm. To better understand the relationship between stress and alcohol consumption, voluntary alcohol intake was also evaluated following additional stressful events later in life, that is, a week of alcohol cessation and a week of alcohol cessation combined with exposure to restraint stress. Female animals consumed more alcohol than males only after a second episode of alcohol cessation combined with restraint stress. MD did not affect baseline voluntary alcohol intake but increased voluntary alcohol intake after stress exposure, indicating that MD may render animals more vulnerable to the effects of stress on alcohol intake. During adolescence, when animals had free access to alcohol, MD animals showed lower body weight gain but a higher growth rate than control animals. Moreover, the higher growth rate was accompanied by a decrease in food intake, suggesting an altered metabolic regulation in MD animals that may interact with alcohol intake.

  18. Sex-dependent maternal deprivation effects on brain monoamine content in adolescent rats.

    Science.gov (United States)

    Llorente, Ricardo; O'Shea, Esther; Gutierrez-Lopez, M Dolores; Llorente-Berzal, Alvaro; Colado, María Isabel; Viveros, María-Paz

    2010-07-26

    Rats subjected to a single prolonged episode of maternal deprivation (MD) [24h, postnatal days 9-10] show, later in life, behavioural alterations that resemble specific signs of schizophrenia and other neuropsychiatric signs including increased levels of impulsivity and an apparent difficulty to cope with stressful situations. Some of these behavioural modifications are observable in the periadolescent period. However there is no previous information regarding the possible underlying neurochemical correlates at this critical developmental period. In this study we have addressed the effects of MD on the levels of serotonin (5-HT), dopamine (DA) and their respective metabolites in prefrontal cortex, hippocampus, striatum, midbrain and cerebellum of male and female periadolescent Wistar rats. MD rats showed significantly increased levels of 5-HT in all regions studied with the exception of cerebellum. In addition, MD animals showed increased levels of DA in PFC as well as increased levels of DA and a decrease of DOPAC/DA and HVA/DA ratios in striatum. The effect of MD on the monoaminergic systems was in several cases sex-dependent.

  19. A Case of Recurrent Transient Monocular Visual Loss after Receiving Sildenafil

    Directory of Open Access Journals (Sweden)

    Asaad Ghanem Ghanem

    2011-01-01

    Full Text Available A 53-year-old man was attended to the Clinic Ophthalmic Center, Mansoura University, Egypt, with recurrent transient monocular visual loss after receiving sildenafil citrate (Viagra for erectile dysfunction. Examination for possible risk factors revealed mild hypercholesterolemia. Family history showed that his father had suffered from bilateral nonarteritic anterior ischemic optic neuropathy (NAION. Physicians might look for arteriosclerotic risk factors and family history of NAION among predisposing risk factors before prescribing sildenafil erectile dysfunction drugs.

  20. Benign pituitary adenoma associated with hyperostosis of the spenoid bone and monocular blindness. Case report.

    Science.gov (United States)

    Milas, R W; Sugar, O; Dobben, G

    1977-01-01

    The authors describe a case of benign chromophobe adenoma associated with hyperostosis of the lesser wing of the sphenoid bone and monocular blindness in a 38-year-old woman. The endocrinological and radiological evaluations were all suggestive of a meningioma. The diagnosis was established by biopsy of the tumor mass. After orbital decompression and removal of the tumor, the patient was treated with radiation therapy. Her postoperative course was uneventful, and her visual defects remained fixed.

  1. Autocalibrating vision guided navigation of unmanned air vehicles via tactical monocular cameras in GPS denied environments

    Science.gov (United States)

    Celik, Koray

    This thesis presents a novel robotic navigation strategy by using a conventional tactical monocular camera, proving the feasibility of using a monocular camera as the sole proximity sensing, object avoidance, mapping, and path-planning mechanism to fly and navigate small to medium scale unmanned rotary-wing aircraft in an autonomous manner. The range measurement strategy is scalable, self-calibrating, indoor-outdoor capable, and has been biologically inspired by the key adaptive mechanisms for depth perception and pattern recognition found in humans and intelligent animals (particularly bats), designed to assume operations in previously unknown, GPS-denied environments. It proposes novel electronics, aircraft, aircraft systems, systems, and procedures and algorithms that come together to form airborne systems which measure absolute ranges from a monocular camera via passive photometry, mimicking that of a human-pilot like judgement. The research is intended to bridge the gap between practical GPS coverage and precision localization and mapping problem in a small aircraft. In the context of this study, several robotic platforms, airborne and ground alike, have been developed, some of which have been integrated in real-life field trials, for experimental validation. Albeit the emphasis on miniature robotic aircraft this research has been tested and found compatible with tactical vests and helmets, and it can be used to augment the reliability of many other types of proximity sensors.

  2. Monocular blur alters the tuning characteristics of stereopsis for spatial frequency and size.

    Science.gov (United States)

    Li, Roger W; So, Kayee; Wu, Thomas H; Craven, Ashley P; Tran, Truyet T; Gustafson, Kevin M; Levi, Dennis M

    2016-09-01

    Our sense of depth perception is mediated by spatial filters at different scales in the visual brain; low spatial frequency channels provide the basis for coarse stereopsis, whereas high spatial frequency channels provide for fine stereopsis. It is well established that monocular blurring of vision results in decreased stereoacuity. However, previous studies have used tests that are broadband in their spatial frequency content. It is not yet entirely clear how the processing of stereopsis in different spatial frequency channels is altered in response to binocular input imbalance. Here, we applied a new stereoacuity test based on narrow-band Gabor stimuli. By manipulating the carrier spatial frequency, we were able to reveal the spatial frequency tuning of stereopsis, spanning from coarse to fine, under blurred conditions. Our findings show that increasing monocular blur elevates stereoacuity thresholds 'selectively' at high spatial frequencies, gradually shifting the optimum frequency to lower spatial frequencies. Surprisingly, stereopsis for low frequency targets was only mildly affected even with an acuity difference of eight lines on a standard letter chart. Furthermore, we examined the effect of monocular blur on the size tuning function of stereopsis. The clinical implications of these findings are discussed.

  3. Measuring method for the object pose based on monocular vision technology

    Science.gov (United States)

    Sun, Changku; Zhang, Zimiao; Wang, Peng

    2010-11-01

    Position and orientation estimation of the object, which can be widely applied in the fields as robot navigation, surgery, electro-optic aiming system, etc, has an important value. The monocular vision positioning algorithm which is based on the point characteristics is studied and new measurement method is proposed in this paper. First, calculate the approximate coordinates of the five reference points which can be used as the initial value of iteration in the camera coordinate system according to weakp3p; Second, get the exact coordinates of the reference points in the camera coordinate system through iterative calculation with the constraints relationship of the reference points; Finally, get the position and orientation of the object. So the measurement model of monocular vision is constructed. In order to verify the accuracy of measurement model, a plane target using infrared LED as reference points is designed to finish the verification of the measurement method and the corresponding image processing algorithm is studied. And then The monocular vision experimental system is established. Experimental results show that the translational positioning accuracy reaches +/-0.05mm and rotary positioning accuracy reaches +/-0.2o .

  4. Sleep deprivation and false confessions.

    Science.gov (United States)

    Frenda, Steven J; Berkowitz, Shari R; Loftus, Elizabeth F; Fenn, Kimberly M

    2016-02-23

    False confession is a major contributor to the problem of wrongful convictions in the United States. Here, we provide direct evidence linking sleep deprivation and false confessions. In a procedure adapted from Kassin and Kiechel [(1996) Psychol Sci 7(3):125-128], participants completed computer tasks across multiple sessions and repeatedly received warnings that pressing the "Escape" key on their keyboard would cause the loss of study data. In their final session, participants either slept all night in laboratory bedrooms or remained awake all night. In the morning, all participants were asked to sign a statement, which summarized their activities in the laboratory and falsely alleged that they pressed the Escape key during an earlier session. After a single request, the odds of signing were 4.5 times higher for the sleep-deprived participants than for the rested participants. These findings have important implications and highlight the need for further research on factors affecting true and false confessions.

  5. Health Effects of Sleep Deprivation,

    Science.gov (United States)

    1990-06-01

    The effects of REM deprivation on electrodermal - activity in human sleep . In Weitzman ED (ed): Adv Sleep Res 2:164-176, 1976. 21. Baust W, Moppeney H...and health consequences of total, selective, and partial sleep loss were documented in this paper by examining adrenimedullary activity ...kinds of sleep loss on the functional integrity of the human organism. The factors discussed include: adrenomedullary activity , adrenocortical activ - ity

  6. The Effects of Sleep Deprivation on Pain

    Directory of Open Access Journals (Sweden)

    Bernd Kundermann

    2004-01-01

    Full Text Available Chronic pain syndromes are associated with alterations in sleep continuity and sleep architecture. One perspective of this relationship, which has not received much attention to date, is that disturbances of sleep affect pain. To fathom this direction of cause, experimental human and animal studies on the effects of sleep deprivation on pain processing were reviewed. According to the majority of the studies, sleep deprivation produces hyperalgesic changes. Furthermore, sleep deprivation can counteract analgesic effects of pharmacological treatments involving opioidergic and serotoninergic mechanisms of action. The heterogeneity of the human data and the exclusive interest in rapid eye movement sleep deprivation in animals so far do not allow us to draw firm conclusions as to whether the hyperalgesic effects are due to the deprivation of specific sleep stages or whether they result from a generalized disruption of sleep continuity. The significance of opioidergic and serotoninergic processes as mediating mechanisms of the hyperalgesic changes produced by sleep deprivation are discussed.

  7. Integrative Medicine Program- MD Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Richard T Lee

    2012-06-01

    Full Text Available The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integrative Medicine Center provides clinical services to patients through individual and group programs.  The clinical philosophy of the center is to work collaboratively with the oncology teams to build comprehensive and integrative care plans that are personalized, evidence-based, and safe with the goal of improving clinical outcomes.  The individual services comprise of integrative oncology consultation, acupuncture, meditation, music therapy, nutrition, and oncology massage.  The center also provides a variety of group programs including meditation, yoga, tai chi, cooking classes and others.  Over the past 13 years, over 70,000 patients and families have participated in services and programs offered by the center.  The research portfolio focuses on three main areas: mind-body interventions, acupuncture, and meditation.  This lecture will focus on providing an overview of the Integrative Medicine Program at MD Anderson with a focus on the clinical services provided.  Participants will learn about the integrative clinical model and how this is applied to the care of cancer patients at MD Anderson Cancer Center.  Current and future research topics will be discussed as well as patient cases.

  8. Relative deprivation and individual well-being

    OpenAIRE

    Chen, Xi

    2015-01-01

    People who are unable to maintain the same standard of living as others around them experience a sense of relative deprivation that has been shown to reduce feelings of well-being. Relative deprivation reflects conditions of worsening relative poverty despite striking reductions in absolute poverty. The effects of relative deprivation explain why average happiness has been stagnant over time despite sharp rises in income. Consumption taxes on status-seeking spending, along with official and t...

  9. Dawbeney Turbervile, MD (1612-1696).

    Science.gov (United States)

    Simunovic, Matthew P

    2012-03-01

    The year 2012 marks the quatercentenary of the birth of Dawbeney Turbervile,MD(1612-1696), one-time Royalist soldier and later ophthalmologist to England’s Princess Anne, the diarist Samuel Pepys, the natural philosopher Robert Boyle, and the astronomer Walter Pope. Turbervile is remarkable for many reasons: He specialized at a time when generalization was prized; though he was a qualified physician, he also practiced the trade of surgery. Furthermore, he provided in his communications with the Royal Society early descriptions of achromatopsia, ocular foreign body removal with a magnet, and tic doloreaux. He is a forebear worth remembering

  10. MD Test of a Ballistic Optics

    CERN Document Server

    Garcia-Tabares Valdivieso, Ana; Salvachua Ferrando, Belen Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Wenninger, Jorg; Coello De Portugal - Martinez Vazquez, Jaime Maria; CERN. Geneva. ATS Department

    2016-01-01

    The ballistic optics is designed to improve the understanding of optical errors and BPM systematic effects in the critical triplet region. The particularity of that optics is that the triplet is switched off, effectively transforming the triplets on both sides of IR1 and IR5 into drift spaces. Advantage can be taken from that fact to localize better errors in the Q4-Q5-triplet region. During this MD this new optics was tested for the first time at injection with beam 2.

  11. Orlando C. Kirton, MD, FACS, FCCM, FCCP.

    Science.gov (United States)

    Pyrtek, Ludwig J

    2007-12-01

    The chair is named for Ludwig J. Pyrtek, MD, an esteemed surgeon at Hartford Hospital, who was devoted to the care of his patients and was an outstanding educator within his chosen field. A unique aspect of the chair is that its income is not used to support the salary of the director but is used to enhance the education activities of the department, such as the purchasing of state-of-the-art teaching devices, support of surgical resident research activities, educational travel for residents and honoraria for nationally/internationally known clinicians/scientists to speak at grand rounds.

  12. SLEEP DEPRIVATION INDUCED ANXIETY AND ANAEROBIC PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Selma Arzu Vardar

    2007-12-01

    Full Text Available The aim of this study was to investigate the effects of sleep deprivation induced anxiety on anaerobic performance. Thirteen volunteer male physical education students completed the Turkish version of State Anxiety Inventory and performed Wingate anaerobic test for three times: (1 following a full-night of habitual sleep (baseline measurements, (2 following 30 hours of sleep deprivation, and (3 following partial-night sleep deprivation. Baseline measurements were performed the day before total sleep deprivation. Measurements following partial sleep deprivation were made 2 weeks later than total sleep deprivation measurements. State anxiety was measured prior to each Wingate test. The mean state anxiety following total sleep deprivation was higher than the baseline measurement (44.9 ± 12.9 vs. 27.6 ± 4.2, respectively, p = 0.02 whereas anaerobic performance parameters remained unchanged. Neither anaerobic parameters nor state anxiety levels were affected by one night partial sleep deprivation. Our results suggest that 30 hours continuous wakefulness may increase anxiety level without impairing anaerobic performance, whereas one night of partial sleep deprivation was ineffective on both state anxiety and anaerobic performance

  13. Maternal deprivation has sexually dimorphic long-term effects on hypothalamic cell-turnover, body weight and circulating hormone levels.

    Science.gov (United States)

    Viveros, María-Paz; Llorente, Ricardo; Díaz, Francisca; Romero-Zerbo, Silvana Y; Bermudez-Silva, Francisco J; Rodríguez de Fonseca, Fernando; Argente, Jesús; Chowen, Julie A

    2010-11-01

    Maternal deprivation (MD) has numerous outcomes, including modulation of neuroendocrine functions. We previously reported that circulating leptin levels are reduced and hypothalamic cell-turnover is affected during MD, with some of these effects being sexually dimorphic. As leptin modulates the development of hypothalamic circuits involved in metabolic control, we asked whether MD has long-term consequences on body weight, leptin levels and the expression of neuropeptides involved in metabolism. Rats were separated from their mother for 24h starting on postnatal day (PND) 9 and sacrificed at PNDs 13, 35 and 75. In both sexes MD reduced body weight, but only until puberty, while leptin levels were unchanged at PND 35 and significantly reduced at PND 75. Adiponectin levels were also reduced at PND 75 in females, while testosterone levels were reduced in males. At PND 13, MD modulated cell-turnover markers in the hypothalamus of males, but not females and increased nestin, a marker of immature neurons, in both sexes, with males having higher levels than females and a significantly greater rise in response to MD. There was no effect of MD on hypothalamic mRNA levels of the leptin receptor or metabolic neuropeptides or the mRNA levels of leptin and adiponectin in adipose tissue. Thus, MD has long-term effects on the levels of circulating hormones that are not correlated with changes in body weight. Furthermore, these endocrine outcomes are different between males and females, which could be due to the fact that MD may have sexually dimorphic effects on hypothalamic development.

  14. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

  15. Cirurgia monocular para esotropias de grande ângulo: um novo paradigma Monocular surgery for large-angle esotropias: a new paradigm

    Directory of Open Access Journals (Sweden)

    Edmilson Gigante

    2009-02-01

    Full Text Available OBJETIVO: Demonstrar a viabilidade da cirurgia monocular no tratamento das esotropias de grande ângulo, praticando-se amplos recuos do reto medial (6 a 10 mm e grandes ressecções do reto lateral (8 a 10 mm. MÉTODOS: Foram operados, com anestesia geral e sem reajustes per ou pósoperatórios, 46 pacientes com esotropias de 50δ ou mais, relativamente comitantes. Os métodos utilizados para refratometria, medida da acuidade visual e do ângulo de desvio, foram os, tradicionalmente, utilizados em estrabologia. No pós-operatório, além das medidas na posição primária do olhar, foi feita uma avaliação da motilidade do olho operado, em adução e em abdução. RESULTADOS: Foram considerados quatro grupos de estudo, correspondendo a quatro períodos de tempo: uma semana, seis meses, dois anos e quatro a sete anos. Os resultados para o ângulo de desvio pós-cirúrgico foram compatíveis com os da literatura em geral e mantiveram-se estáveis ao longo do tempo. A motilidade do olho operado apresentou pequena limitação em adução e nenhuma em abdução, contrariando o encontrado na literatura estrabológica. Comparando os resultados de adultos com os de crianças e de amblíopes com não amblíopes, não foram encontradas diferenças estatisticamente significativas entre eles. CONCLUSÃO:Em face dos resultados encontrados, entende-se ser possível afirmar que a cirurgia monocular de recuo-ressecção pode ser considerada opção viável para o tratamento das esotropias de grande ângulo, tanto para adultos quanto para crianças, bem como para amblíopes e não amblíopes.PURPOSE: To demonstrate the feasibility of monocular surgery in the treatment of large-angle esotropias through large recessions of the medial rectus (6 to 10 mm and large resections of the lateral rectus (8 to 10 mm. METHODS: 46 patients were submitted to surgery. They had esotropias of 50Δor more that were relatively comitant. The patients were operated under general

  16. Maternal deprivation of rat pups reduces body weight and alters behavior in adulthood in a gender-specific manner

    Directory of Open Access Journals (Sweden)

    Đorđević Jelena

    2015-01-01

    Full Text Available The early postnatal environment is critical for its capacity to influence adult behavior, and is associated with traits of altered physiological and neurobiological function and long-term predisposition to depression. Here we describe the delayed effects of maternal deprivation (MD in male and female Wistar pups on their physical development and behavior in adulthood in tasks designed to explore depressive-like (forced swimming test, FST, and anxiety-like behaviors (elevated plus maze, EPM. We observed that MD led to reduced body weight in adulthood, anxiety-like traits in the EPM test and increased activity in the phases of the FST. Particularly, a consistent sexual dimorphism was observed in the responses to MD. A lower increase in body weight during maturation of MD rats was more pronounced in males than in females. MD anxiogenic effects were more pronounced in females, while in FST only MD males showed a marked increase in swimming activity followed by decreased immobility. [Projekat Ministarstva nauke Republike Srbije, br. III41029

  17. Relative deprivation and political protest

    Directory of Open Access Journals (Sweden)

    R. M. Kliuchnyk

    2017-03-01

    Examples of anti-system political parties and movements have been given. Many of them have changed the political disposition in Europe. Lega Nord (Italy, PEGIDA (Germany, Movimento 5 Stelle (Italy, Front National (France, Ataka (Bulgaria, etc are between them. These parties and movements influence increasingly on the European political process. Nativism and populism are marked as main peculiarities of such right parties. According to the author, Anti-Trump protests in the USA are the examples of the relative deprivation of numerous groups of people that feel their rights and freedoms being threatened.

  18. Learning Depth from Single Monocular Images Using Deep Convolutional Neural Fields.

    Science.gov (United States)

    Liu, Fayao; Shen, Chunhua; Lin, Guosheng; Reid, Ian

    2016-10-01

    In this article, we tackle the problem of depth estimation from single monocular images. Compared with depth estimation using multiple images such as stereo depth perception, depth from monocular images is much more challenging. Prior work typically focuses on exploiting geometric priors or additional sources of information, most using hand-crafted features. Recently, there is mounting evidence that features from deep convolutional neural networks (CNN) set new records for various vision applications. On the other hand, considering the continuous characteristic of the depth values, depth estimation can be naturally formulated as a continuous conditional random field (CRF) learning problem. Therefore, here we present a deep convolutional neural field model for estimating depths from single monocular images, aiming to jointly explore the capacity of deep CNN and continuous CRF. In particular, we propose a deep structured learning scheme which learns the unary and pairwise potentials of continuous CRF in a unified deep CNN framework. We then further propose an equally effective model based on fully convolutional networks and a novel superpixel pooling method, which is about 10 times faster, to speedup the patch-wise convolutions in the deep model. With this more efficient model, we are able to design deeper networks to pursue better performance. Our proposed method can be used for depth estimation of general scenes with no geometric priors nor any extra information injected. In our case, the integral of the partition function can be calculated in a closed form such that we can exactly solve the log-likelihood maximization. Moreover, solving the inference problem for predicting depths of a test image is highly efficient as closed-form solutions exist. Experiments on both indoor and outdoor scene datasets demonstrate that the proposed method outperforms state-of-the-art depth estimation approaches.

  19. More clinical observations on migraine associated with monocular visual symptoms in an Indian population

    Directory of Open Access Journals (Sweden)

    Vishal Jogi

    2016-01-01

    Full Text Available Context: Retinal migraine (RM is considered as one of the rare causes of transient monocular visual loss (TMVL and has not been studied in Indian population. Objectives: The study aims to analyze the clinical and investigational profile of patients with RM. Materials and Methods: This is an observational prospective analysis of 12 cases of TMVL fulfilling the International Classification of Headache Disorders-2nd edition (ICHD-II criteria of RM examined in Neurology and Ophthalmology Outpatient Department (OPD of Postgraduate Institute of Medical Education and Research (PGIMER, Chandigarh from July 2011 to October 2012. Results: Most patients presented in 3 rd and 4 th decade with equal sex distribution. Seventy-five percent had antecedent migraine without aura (MoA and 25% had migraine with Aura (MA. Headache was ipsilateral to visual symptoms in 67% and bilateral in 33%. TMVL preceded headache onset in 58% and occurred during headache episode in 42%. Visual symptoms were predominantly negative except in one patient who had positive followed by negative symptoms. Duration of visual symptoms was variable ranging from 30 s to 45 min. None of the patient had permanent monocular vision loss. Three patients had episodes of TMVL without headache in addition to the symptom constellation defining RM. Most of the tests done to rule out alternative causes were normal. Magnetic resonance imaging (MRI brain showed nonspecific white matter changes in one patient. Visual-evoked potential (VEP showed prolonged P100 latencies in two cases. Patent foramen ovale was detected in one patient. Conclusions: RM is a definite subtype of migraine and should remain in the ICHD classification. It should be kept as one of the differential diagnosis of transient monocular vision loss. We propose existence of "acephalgic RM" which may respond to migraine prophylaxis.

  20. P2-1: Visual Short-Term Memory Lacks Sensitivity to Stereoscopic Depth Changes but is Much Sensitive to Monocular Depth Changes

    Directory of Open Access Journals (Sweden)

    Hae-In Kang

    2012-10-01

    Full Text Available Depth from both binocular disparity and monocular depth cues presumably is one of most salient features that would characterize a variety of visual objects in our daily life. Therefore it is plausible to expect that human vision should be good at perceiving objects' depth change arising from binocular disparities and monocular pictorial cues. However, what if the estimated depth needs to be remembered in visual short-term memory (VSTM rather than just perceived? In a series of experiments, we asked participants to remember depth of items in an array at the beginning of each trial. A set of test items followed after the memory array, and the participants were asked to report if one of the items in the test array have changed its depth from the remembered items or not. The items would differ from each other in three different depth conditions: (1 stereoscopic depth under binocular disparity manipulations, (2 monocular depth under pictorial cue manipulations, and (3 both stereoscopic and monocular depth. The accuracy of detecting depth change was substantially higher in the monocular condition than in the binocular condition, and the accuracy in the both-depth condition was moderately improved compared to the monocular condition. These results indicate that VSTM benefits more from monocular depth than stereoscopic depth, and further suggests that storage of depth information into VSTM would require both binocular and monocular information for its optimal memory performance.

  1. Paradoxical sleep deprivation increases plasma endothelin levels

    Directory of Open Access Journals (Sweden)

    B.D. Palma

    2002-01-01

    Full Text Available The endothelins (ET-1, 2 and 3 constitute a family of 21 amino acid peptides with potent biological activities. ET-1 is one of the most potent endogenous vasoconstrictors so far identified and its increased concentration in plasma appears to be closely related to the pathogenesis of arterial hypertension as well as to obstructive sleep apnea (OSA. OSA patients exhibit repetitive episodes of apnea and hypopnea that result in hypoxia and consecutive arousals. These patients are chronically sleep deprived, which may aggravate the hypertensive features, since literature data show that sleep deprivation results in hypertension both in humans and in animals. Based on the reported relationship between ET-1, hypertension and sleep deprivation consequences, the purpose of the present study was to determine plasma ET concentrations in paradoxical sleep-deprived animals. Male Wistar rats, 3 to 4 months old (N = 10 per group, were deprived of sleep for 24 and 96 h by the platform technique and plasma ET-1/2 was measured by radioimmunoassay. Analysis of plasma revealed that 96 h of sleep deprivation induced a significant increase in ET-1/2 release (6.58 fmol/ml compared to control (5.07 fmol/ml. These data show that sleep deprivation altered plasma ET-1/2 concentrations, suggesting that such an increase may participate in the genesis of arterial hypertension and cardiorespiratory changes observed after sleep deprivation.

  2. Relative Deprivation in Contemporary South Africa.

    Science.gov (United States)

    Appelgryn, Ans E. M.; Bornman, Elirea

    1996-01-01

    Identifies relative deprivation as a subjective feeling of discontent based on a belief that one is getting less than one feels entitled to. Investigates the relationship between relative deprivation, ethnic identification, and racial attitudes in South Africa. Discusses the connections between these beliefs and recent sociopolitical changes. (MJP)

  3. A Model of Egoistical Relative Deprivation

    Science.gov (United States)

    Crosby, Faye

    1976-01-01

    Examines the theory of relative deprivation. This theory states, basically, that objective and subjective well-being are not isomorphically related, so that sometimes the better-off one is, the worse-off one feels subjectively. After a brief review of work in the area of relative deprivation, a formal model is developed. (Editor/RK)

  4. Motor development after vestibular deprivation in rats

    NARCIS (Netherlands)

    Geisler, HC; Gramsbergen, A

    1998-01-01

    This review summarizes the postural development in the rat and the influences of vestibular deprivation from the 5th postnatal day on this development. Vestibular deprivation leads to a delay in motor development. Most probably this delay is caused by a delay in the development of postural control,

  5. WHAT IS LACKING, STATEMENT ON SENSORY DEPRIVATION.

    Science.gov (United States)

    REGAN, J.

    THIS PAPER, WHICH ANNOUNCES THE THEME OF A SEMINAR ON THEORIES OF LANGUAGE AND LEARNING, QUESTIONS THE VIEW THAT A CHILD'S POOR SCHOOL PERFORMANCE DERIVES FROM AN IMPOVERISHED SENSORY EXPERIENCE. A DEPRIVED TROPICAL ENVIRONMENT IS DEPICTED TO CAST DOUBTS ON THIS THEORY. A BIBLIOGRAPHY OF THE EFFECTS OF SENSORY DEPRIVATION IS INCLUDED. THIS…

  6. Neural correlates of monocular and binocular depth cues based on natural images: a LORETA analysis.

    Science.gov (United States)

    Fischmeister, Florian Ph S; Bauer, Herbert

    2006-10-01

    Functional imaging studies investigating perception of depth rely solely on one type of depth cue based on non-natural stimulus material. To overcome these limitations and to provide a more realistic and complete set of depth cues natural stereoscopic images were used in this study. Using slow cortical potentials and source localization we aimed to identify the neural correlates of monocular and binocular depth cues. This study confirms and extends functional imaging studies, showing that natural images provide a good, reliable, and more realistic alternative to artificial stimuli, and demonstrates the possibility to separate the processing of different depth cues.

  7. Three dimensional monocular human motion analysis in end-effector space

    DEFF Research Database (Denmark)

    Hauberg, Søren; Lapuyade, Jerome; Engell-Nørregård, Morten Pol

    2009-01-01

    In this paper, we present a novel approach to three dimensional human motion estimation from monocular video data. We employ a particle filter to perform the motion estimation. The novelty of the method lies in the choice of state space for the particle filter. Using a non-linear inverse kinemati...... solver allows us to perform the filtering in end-effector space. This effectively reduces the dimensionality of the state space while still allowing for the estimation of a large set of motions. Preliminary experiments with the strategy show good results compared to a full-pose tracker....

  8. Effect of ophthalmic filter thickness on predicted monocular dichromatic luminance and chromaticity discrimination.

    Science.gov (United States)

    Richer, S P; Little, A C; Adams, A J

    1984-11-01

    The majority of ophthalmic filters, whether they be in the form of spectacles or contact lenses, are absorbance type filters. Although color vision researchers routinely provide spectrophotometric transmission profiles of filters, filter thickness is rarely specified. In this paper, colorimetric tools and volume color theory are used to show that the color of a filter as well as its physical properties are altered dramatically by changes in thickness. The effect of changes in X-Chrom filter thickness on predicted monocular dichromatic luminance and chromaticity discrimination is presented.

  9. Estimating 3D positions and velocities of projectiles from monocular views.

    Science.gov (United States)

    Ribnick, Evan; Atev, Stefan; Papanikolopoulos, Nikolaos P

    2009-05-01

    In this paper, we consider the problem of localizing a projectile in 3D based on its apparent motion in a stationary monocular view. A thorough theoretical analysis is developed, from which we establish the minimum conditions for the existence of a unique solution. The theoretical results obtained have important implications for applications involving projectile motion. A robust, nonlinear optimization-based formulation is proposed, and the use of a local optimization method is justified by detailed examination of the local convexity structure of the cost function. The potential of this approach is validated by experimental results.

  10. Monocular feature tracker for low-cost stereo vision control of an autonomous guided vehicle (AGV)

    Science.gov (United States)

    Pearson, Chris M.; Probert, Penelope J.

    1994-02-01

    We describe a monocular feature tracker (MFT), the first stage of a low cost stereoscopic vision system for use on an autonomous guided vehicle (AGV) in an indoor environment. The system does not require artificial markings or other beacons, but relies upon accurate knowledge of the AGV motion. Linear array cameras (LAC) are used to reduce the data and processing bandwidths. The limited information given by LAC require modelling of the expected features. We model an obstacle as a vertical line segment touching the floor, and can distinguish between these obstacles and most other clutter in an image sequence. Detection of these obstacles is sufficient information for local AGV navigation.

  11. Long-Term Effects of Maternal Deprivation on the Neuronal Soma Area in the Rat Neocortex

    Directory of Open Access Journals (Sweden)

    Milan Aksić

    2014-01-01

    Full Text Available Early separation of rat pups from their mothers (separatio a matrem is considered and accepted as an animal model of perinatal stress. Adult rats, separated early postnatally from their mothers, are developing long-lasting changes in the brain and neuroendocrine system, corresponding to the findings observed in schizophrenia and affective disorders. With the aim to investigate the morphological changes in this animal model we exposed 9-day-old (P9 Wistar rats to a 24 h maternal deprivation (MD. At young adult age rats were sacrificed for morphometric analysis and their brains were compared with the control group bred under the same conditions, but without MD. Rats exposed to MD had a 28% smaller cell soma area in the prefrontal cortex (PFCX, 30% in retrosplenial cortex (RSCX, and 15% in motor cortex (MCX compared to the controls. No difference was observed in the expression of glial fibrillary acidic protein in the neocortex of MD rats compared to the control group. The results of this study demonstrate that stress in early life has a long-term effect on neuronal soma size in cingulate and retrosplenial cortex and is potentially interesting as these structures play an important role in cognition.

  12. Infants' ability to respond to depth from the retinal size of human faces: comparing monocular and binocular preferential-looking.

    Science.gov (United States)

    Tsuruhara, Aki; Corrow, Sherryse; Kanazawa, So; Yamaguchi, Masami K; Yonas, Albert

    2014-11-01

    To examine sensitivity to pictorial depth cues in young infants (4 and 5 months-of-age), we compared monocular and binocular preferential looking to a display on which two faces were equidistantly presented and one was larger than the other, depicting depth from the size of human faces. Because human faces vary little in size, the correlation between retinal size and distance can provide depth information. As a result, adults perceive a larger face as closer than a smaller one. Although binocular information for depth provided information that the faces in our display were equidistant, under monocular viewing, no such information was provided. Rather, the size of the faces indicated that one was closer than the other. Infants are known to look longer at apparently closer objects. Therefore, we hypothesized that infants would look longer at a larger face in the monocular than in the binocular condition if they perceived depth from the size of human faces. Because the displays were identical in the two conditions, any difference in looking-behavior between monocular and binocular viewing indicated sensitivity to depth information. Results showed that 5-month-old infants preferred the larger, apparently closer, face in the monocular condition compared to the binocular condition when static displays were presented. In addition, when presented with a dynamic display, 4-month-old infants showed a stronger 'closer' preference in the monocular condition compared to the binocular condition. This was not the case when the faces were inverted. These results suggest that even 4-month-old infants respond to depth information from a depth cue that may require learning, the size of faces. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. Infants’ ability to respond to depth from the retinal size of human faces: Comparing monocular and binocular preferential-looking

    Science.gov (United States)

    Tsuruhara, Aki; Corrow, Sherryse; Kanazawa, So; Yamaguchi, Masami K.; Yonas, Albert

    2014-01-01

    To examine sensitivity to pictorial depth cues in young infants (4 and 5 months-of-age), we compared monocular and binocular preferential looking to a display on which two faces were equidistantly presented and one was larger than the other, depicting depth from the size of human faces. Because human faces vary little in size, the correlation between retinal size and distance can provide depth information. As a result, adults perceive a larger face as closer than a smaller one. Although binocular information for depth provided information that the faces in our display were equidistant, under monocular viewing, no such information was provided. Rather, the size of the faces indicated that one was closer than the other. Infants are known to look longer at apparently closer objects. Therefore, we hypothesized that infants would look longer at a larger face in the monocular than in the binocular condition if they perceived depth from the size of human faces. Because the displays were identical in the two conditions, any difference in looking-behavior between monocular and binocular viewing indicated sensitivity to depth information. Results showed that 5-month-old infants preferred the larger, apparently closer, face in the monocular condition compared to the binocular condition when static displays were presented. In addition, when presented with a dynamic display, 4-month-old infants showed a stronger ‘closer’ preference in the monocular condition compared to the binocular condition. This was not the case when the faces were inverted. These results suggest that even 4-month-old infants respond to depth information from a depth cue that may require learning, the size of faces. PMID:25113916

  14. Halo Scraping, Diffusion and Repopulation MD

    CERN Document Server

    Valentino, G; Bruce, R; Burkart, F; Redaelli, F; Salvachua, B; Previtali, V; Stancari, G; Valishev, A

    2012-01-01

    Beam halo measurements in the LHC were conducted through collimator scrapings in an MD carried out on the 22nd June 2012 for the first time at 4 TeV. The time evolution of losses during a collimator scan provides information on halo diffusion and population. Four scans were performed with two collimators in the vertical and horizontal plane in B1 and B2 respectively, before and after bringing the beams into collisions. During an inward step, the beam losses measured at the BLMs for the first 3 seconds are believed to be dominated by multi-turn halo removal by the collimator jaw. However, a good comparison was found between fits of the diffusion model and the subsequent loss decay. In addition, the fitted diffusion coefficients compare well to the coefficients estimated from the core emittance growth rates as a function of action.

  15. Maternal deprivation effects on brain plasticity and recognition memory in adolescent male and female rats.

    Science.gov (United States)

    Marco, Eva M; Valero, Manuel; de la Serna, Oscar; Aisa, Barbara; Borcel, Erika; Ramirez, Maria Javier; Viveros, María-Paz

    2013-05-01

    Data from both human and animal studies suggest that exposure to stressful life events at neonatal stages may increase the risk of psychopathology at adulthood. In particular, early maternal deprivation, 24 h at postnatal day (pnd) 9, has been associated with persistent neurobehavioural changes similar to those present in developmental psychopathologies such as depression and schizophrenic-related disorders. Most neuropsychiatric disorders first appear during adolescence, however, the effects of MD on adolescent animals' brain and behaviour have been scarcely explored. In the present study, we aimed to investigate the emotional and cognitive consequences of MD in adolescent male and female rats, as well as possible underlying neurobiological mechanisms within frontal cortex and hippocampus. Animals were exposed to a battery of behavioural tasks, from pnd 35 to 42, to evaluate cognitive [spontaneous alternation task (SAT) and novel object test (NOT)] and anxiety-related responses [elevated plus maze (EPM)] during adolescence. Changes in neuronal and glial cells, alterations in synaptic plasticity as well as modifications in cannabinoid receptor expression were investigated in a parallel group of control and adolescent (pnd 40) male and female animals. Notably, MD induced a significant impairment in recognition memory exclusively among females. A generalized decrease in NeuN expression was found in MD animals, together with an increase in hippocampal glial fibrillar acidic protein (GFAP) expression exclusively among MD adolescent males. In addition, MD induced in the frontal cortex and hippocampus of male and female adolescent rats a significant reduction in brain derived neurotrophic factor (BDNF) and postsynaptic density (PSD95) levels, together with a decrease in synaptophysin in frontal cortex and neural cell adhesion molecule (NCAM) in hippocampus. MD induced, in animals of both sexes, a significant reduction in CB1R expression, but an increase in CB2R that was

  16. Long Term Hippocampal and Cortical Changes Induced by Maternal Deprivation and Neonatal Leptin Treatment in Male and Female Rats.

    Science.gov (United States)

    Mela, Virginia; Díaz, Francisca; Borcel, Erika; Argente, Jesús; Chowen, Julie A; Viveros, Maria-Paz

    2015-01-01

    Maternal deprivation (MD) during neonatal life has diverse long-term behavioral effects and alters the development of the hippocampus and frontal cortex, with several of these effects being sexually dimorphic. MD animals show a marked reduction in their circulating leptin levels, not only during the MD period, but also several days later (PND 13). A neonatal leptin surge occurs in rodents (beginning around PND 5 and peaking between PND 9 and 10) that has an important neurotrophic role. We hypothesized that the deficient neonatal leptin signaling of MD rats could be involved in the altered development of their hippocampus and frontal cortex. Accordingly, a neonatal leptin treatment in MD rats would at least in part counteract their neurobehavioural alterations. MD was carried out in Wistar rats for 24 h on PND 9. Male and female MD and control rats were treated from PND 9 to 13 with rat leptin (3 mg/kg/day sc) or vehicle. In adulthood, the animals were submitted to the open field, novel object memory test and the elevated plus maze test of anxiety. Neuronal and glial population markers, components of the glutamatergic and cannabinoid systems and diverse synaptic plasticity markers were evaluated by PCR and/or western blotting. Main results include: 1) In some of the parameters analyzed, neonatal leptin treatment reversed the effects of MD (eg., mRNA expression of hippocampal IGF1 and protein expression of GFAP and vimentin) partially confirming our hypothesis; 2) The neonatal leptin treatment, per se, exerted a number of behavioral (increased anxiety) and neural effects (eg., expression of the following proteins: NG2, NeuN, PSD95, NCAM, synaptophysin). Most of these effects were sex dependent. An adequate neonatal leptin level (avoiding excess and deficiency) appears to be necessary for its correct neuro-programing effect.

  17. MD1228: Validation of Single Bunch Stability Threshold & MD1751: Instability Studies with a Single Beam

    CERN Document Server

    Carver, Lee Robert; Biancacci, Nicolo; Buffat, Xavier; Iadarola, Giovanni; Lasocha, Kacper; Li, Kevin Shing Bruce; Levens, Tom; Metral, Elias; Salvant, Benoit; Tambasco, Claudia; CERN. Geneva. ATS Department

    2017-01-01

    Instabilities were being routinely observed in B1V during ADJUST. The timing of the instabilities has been localised to shortly after the TOTEM bump has been implemented. The result is emittance blowup which can negatively effect the luminosity output of the fill. This MD aimed to rule out possible sources of the instability (i.e. beam-beam effects or electron cloud) by only taking one single beam to 6.5TeV and going through the full machine cycle. After the implementation of the TOTEM bump, a reduction of the octupole current was performed in order to determine if there was a discrepancy in the threshold between simulations and measurement. As a precursor, the results of the End of Fill MD: Validation of Single Bunch Stability Threshold will also be described.

  18. An Analytical Measuring Rectification Algorithm of Monocular Systems in Dynamic Environment

    Directory of Open Access Journals (Sweden)

    Deshi Li

    2016-01-01

    Full Text Available Range estimation is crucial for maintaining a safe distance, in particular for vision navigation and localization. Monocular autonomous vehicles are appropriate for outdoor environment due to their mobility and operability. However, accurate range estimation using vision system is challenging because of the nonholonomic dynamics and susceptibility of vehicles. In this paper, a measuring rectification algorithm for range estimation under shaking conditions is designed. The proposed method focuses on how to estimate range using monocular vision when a shake occurs and the algorithm only requires the pose variations of the camera to be acquired. Simultaneously, it solves the problem of how to assimilate results from different kinds of sensors. To eliminate measuring errors by shakes, we establish a pose-range variation model. Afterwards, the algebraic relation between distance increment and a camera’s poses variation is formulated. The pose variations are presented in the form of roll, pitch, and yaw angle changes to evaluate the pixel coordinate incensement. To demonstrate the superiority of our proposed algorithm, the approach is validated in a laboratory environment using Pioneer 3-DX robots. The experimental results demonstrate that the proposed approach improves in the range accuracy significantly.

  19. Stereo improves 3D shape discrimination even when rich monocular shape cues are available.

    Science.gov (United States)

    Lee, Young Lim; Saunders, Jeffrey A

    2011-08-17

    We measured the ability to discriminate 3D shapes across changes in viewpoint and illumination based on rich monocular 3D information and tested whether the addition of stereo information improves shape constancy. Stimuli were images of smoothly curved, random 3D objects. Objects were presented in three viewing conditions that provided different 3D information: shading-only, stereo-only, and combined shading and stereo. Observers performed shape discrimination judgments for sequentially presented objects that differed in orientation by rotation of 0°-60° in depth. We found that rotation in depth markedly impaired discrimination performance in all viewing conditions, as evidenced by reduced sensitivity (d') and increased bias toward judging same shapes as different. We also observed a consistent benefit from stereo, both in conditions with and without change in viewpoint. Results were similar for objects with purely Lambertian reflectance and shiny objects with a large specular component. Our results demonstrate that shape perception for random 3D objects is highly viewpoint-dependent and that stereo improves shape discrimination even when rich monocular shape cues are available.

  20. Higher resolution stimulus facilitates depth perception: MT+ plays a significant role in monocular depth perception.

    Science.gov (United States)

    Tsushima, Yoshiaki; Komine, Kazuteru; Sawahata, Yasuhito; Hiruma, Nobuyuki

    2014-10-20

    Today, we human beings are facing with high-quality virtual world of a completely new nature. For example, we have a digital display consisting of a high enough resolution that we cannot distinguish from the real world. However, little is known how such high-quality representation contributes to the sense of realness, especially to depth perception. What is the neural mechanism of processing such fine but virtual representation? Here, we psychophysically and physiologically examined the relationship between stimulus resolution and depth perception, with using luminance-contrast (shading) as a monocular depth cue. As a result, we found that a higher resolution stimulus facilitates depth perception even when the stimulus resolution difference is undetectable. This finding is against the traditional cognitive hierarchy of visual information processing that visual input is processed continuously in a bottom-up cascade of cortical regions that analyze increasingly complex information such as depth information. In addition, functional magnetic resonance imaging (fMRI) results reveal that the human middle temporal (MT+) plays a significant role in monocular depth perception. These results might provide us with not only the new insight of our neural mechanism of depth perception but also the future progress of our neural system accompanied by state-of- the-art technologies.

  1. Incorporating a Wheeled Vehicle Model in a New Monocular Visual Odometry Algorithm for Dynamic Outdoor Environments

    Directory of Open Access Journals (Sweden)

    Yanhua Jiang

    2014-09-01

    Full Text Available This paper presents a monocular visual odometry algorithm that incorporates a wheeled vehicle model for ground vehicles. The main innovation of this algorithm is to use the single-track bicycle model to interpret the relationship between the yaw rate and side slip angle, which are the two most important parameters that describe the motion of a wheeled vehicle. Additionally, the pitch angle is also considered since the planar-motion hypothesis often fails due to the dynamic characteristics of wheel suspensions and tires in real-world environments. Linearization is used to calculate a closed-form solution of the motion parameters that works as a hypothesis generator in a RAndom SAmple Consensus (RANSAC scheme to reduce the complexity in solving equations involving trigonometric. All inliers found are used to refine the winner solution through minimizing the reprojection error. Finally, the algorithm is applied to real-time on-board visual localization applications. Its performance is evaluated by comparing against the state-of-the-art monocular visual odometry methods using both synthetic data and publicly available datasets over several kilometers in dynamic outdoor environments.

  2. Cortical dynamics of three-dimensional form, color, and brightness perception. 1. Monocular theory

    Energy Technology Data Exchange (ETDEWEB)

    Grossberg, S.

    1987-01-01

    A real-time visual-processing theory is developed to explain how three-dimensional form, color, and brightness percepts are coherently synthesized. The theory describes how several fundamental uncertainty principles that limit the computation of visual information at individual processing stages are resolved through parallel and hierarchical interactions among several processing stages. The theory provides unified analysis and many predictions of data about stereopsis, binocular rivalry, hyperacuity, McCollough effect, textural grouping, border distinctness, surface perception, monocular and binocular brightness percepts, filling-in, metacontrast, transparency, figural aftereffects, lateral inhibition within spatial frequency channels, proximity luminance covariance, tissue contrast, motion segmentation, and illusory figures, as well as about reciprocal interactions among the hypercolumns, blobs, and stripes of cortical areas V1, V2, and V4. Monocular and binocular interactions between a Boundary Contour (BC) System and a Feature Contour (FC) System are developed. The BC System, defined by a hierarchy of oriented interactions, synthesizes an emergent and coherent binocular boundary segmentation from combinations of unoriented and oriented scenic elements.

  3. A trajectory and orientation reconstruction method for moving objects based on a moving monocular camera.

    Science.gov (United States)

    Zhou, Jian; Shang, Yang; Zhang, Xiaohu; Yu, Wenxian

    2015-03-09

    We propose a monocular trajectory intersection method to solve the problem that a monocular moving camera cannot be used for three-dimensional reconstruction of a moving object point. The necessary and sufficient condition of when this method has the unique solution is provided. An extended application of the method is to not only achieve the reconstruction of the 3D trajectory, but also to capture the orientation of the moving object, which would not be obtained by PnP problem methods due to lack of features. It is a breakthrough improvement that develops the intersection measurement from the traditional "point intersection" to "trajectory intersection" in videometrics. The trajectory of the object point can be obtained by using only linear equations without any initial value or iteration; the orientation of the object with poor conditions can also be calculated. The required condition for the existence of definite solution of this method is derived from equivalence relations of the orders of the moving trajectory equations of the object, which specifies the applicable conditions of the method. Simulation and experimental results show that it not only applies to objects moving along a straight line, or a conic and another simple trajectory, but also provides good result for more complicated trajectories, making it widely applicable.

  4. Monocular 3D Reconstruction and Augmentation of Elastic Surfaces with Self-Occlusion Handling.

    Science.gov (United States)

    Haouchine, Nazim; Dequidt, Jeremie; Berger, Marie-Odile; Cotin, Stephane

    2015-12-01

    This paper focuses on the 3D shape recovery and augmented reality on elastic objects with self-occlusions handling, using only single view images. Shape recovery from a monocular video sequence is an underconstrained problem and many approaches have been proposed to enforce constraints and resolve the ambiguities. State-of-the art solutions enforce smoothness or geometric constraints, consider specific deformation properties such as inextensibility or resort to shading constraints. However, few of them can handle properly large elastic deformations. We propose in this paper a real-time method that uses a mechanical model and able to handle highly elastic objects. The problem is formulated as an energy minimization problem accounting for a non-linear elastic model constrained by external image points acquired from a monocular camera. This method prevents us from formulating restrictive assumptions and specific constraint terms in the minimization. In addition, we propose to handle self-occluded regions thanks to the ability of mechanical models to provide appropriate predictions of the shape. Our method is compared to existing techniques with experiments conducted on computer-generated and real data that show the effectiveness of recovering and augmenting 3D elastic objects. Additionally, experiments in the context of minimally invasive liver surgery are also provided and results on deformations with the presence of self-occlusions are exposed.

  5. Mobile Target Tracking Based on Hybrid Open-Loop Monocular Vision Motion Control Strategy

    Directory of Open Access Journals (Sweden)

    Cao Yuan

    2015-01-01

    Full Text Available This paper proposes a new real-time target tracking method based on the open-loop monocular vision motion control. It uses the particle filter technique to predict the moving target’s position in an image. Due to the properties of the particle filter, the method can effectively master the motion behaviors of the linear and nonlinear. In addition, the method uses the simple mathematical operation to transfer the image information in the mobile target to its real coordinate information. Therefore, it requires few operating resources. Moreover, the method adopts the monocular vision approach, which is a single camera, to achieve its objective by using few hardware resources. Firstly, the method evaluates the next time’s position and size of the target in an image. Later, the real position of the objective corresponding to the obtained information is predicted. At last, the mobile robot should be controlled in the center of the camera’s vision. The paper conducts the tracking test to the L-type and the S-type and compares with the Kalman filtering method. The experimental results show that the method achieves a better tracking effect in the L-shape experiment, and its effect is superior to the Kalman filter technique in the L-type or S-type tracking experiment.

  6. Cataract surgery: emotional reactions of patients with monocular versus binocular vision

    Directory of Open Access Journals (Sweden)

    Roberta Ferrari Marback

    2012-12-01

    Full Text Available PURPOSE: To analyze emotional reactions related to cataract surgery in two groups of patients (monocular vision - Group 1; binocular vision - Group 2. METHODS: A transversal comparative study was performed using a structured questionnaire from a previous exploratory study before cataract surgery. RESULTS: 206 patients were enrolled in the study, 96 individuals in Group 1 (69.3 ± 10.4 years and 110 in Group 2 (68.2 ± 10.2 years. Most patients in group 1 (40.6% and 22.7% of group 2, reported fear of surgery (p<0.001. The most important causes of fear were: possibility of blindness, ocular complications and death during surgery. The most prevalent feelings among the groups were doubts about good results and nervousness. CONCLUSION: Patients with monocular vision reported more fear and doubts related to surgical outcomes. Thus, it is necessary that phisycians considers such emotional reactions and invest more time than usual explaining the risks and the benefits of cataract surgery.Ouvir

  7. Monocular tool control, eye dominance, and laterality in New Caledonian crows.

    Science.gov (United States)

    Martinho, Antone; Burns, Zackory T; von Bayern, Auguste M P; Kacelnik, Alex

    2014-12-15

    Tool use, though rare, is taxonomically widespread, but morphological adaptations for tool use are virtually unknown. We focus on the New Caledonian crow (NCC, Corvus moneduloides), which displays some of the most innovative tool-related behavior among nonhumans. One of their major food sources is larvae extracted from burrows with sticks held diagonally in the bill, oriented with individual, but not species-wide, laterality. Among possible behavioral and anatomical adaptations for tool use, NCCs possess unusually wide binocular visual fields (up to 60°), suggesting that extreme binocular vision may facilitate tool use. Here, we establish that during natural extractions, tool tips can only be viewed by the contralateral eye. Thus, maintaining binocular view of tool tips is unlikely to have selected for wide binocular fields; the selective factor is more likely to have been to allow each eye to see far enough across the midsagittal line to view the tool's tip monocularly. Consequently, we tested the hypothesis that tool side preference follows eye preference and found that eye dominance does predict tool laterality across individuals. This contrasts with humans' species-wide motor laterality and uncorrelated motor-visual laterality, possibly because bill-held tools are viewed monocularly and move in concert with eyes, whereas hand-held tools are visible to both eyes and allow independent combinations of eye preference and handedness. This difference may affect other models of coordination between vision and mechanical control, not necessarily involving tools. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. Maternal nutrition in deprived populations.

    Science.gov (United States)

    Shah, K P

    1981-02-01

    In deprived populations, a large proportion of women are chronically undernourished, the chances being therefore great that their infants will be undernourished in utero and present a low birth weight. Their children thus have a poor start in life, for which even breastmilk with its special protective and nutritive qualities cannot completely compensate, especially if the mothers continue to be chronically malnourished while subject to heavy workloads and repeated pregnancies. The supplementary feeding of pregnant and lactating women can to some extent offset these negative effects on both mother and child, but constitute a late intervention. Current literature on these issues is reviewed, and areas of action to improve women's nutritional status are indicated. In order to ensure that those most in need are reached at the grass roots level, the actions undertaken should be based on community participation, within the context of a multisectoral approach and a primary health care strategy.

  9. BI MD studies on April 22nd 2012 (LHC MD-1)

    CERN Document Server

    Baer, T; Boccardi, A; Burger, S; Calvo, E; Dehning, B; Emery, J; Gasior, M; Guerrero, A; Jones, R; Lefevre, T; Gras, JJ; Rabiller, A; Roncarolo, F; Sapinski, M; Steinhagen, R; Trad, G

    2012-01-01

    During the LHC MD block 1 in 2012, eight hours were dedicated to beam instrumentation studies. Such a period was spent mainly for estimating the betatron functions at the location of the transverse profile monitors in IR4 via the K-Modulation method and for characterizing the BSRT extraction mirror heating with high intensity beams. This note discusses the measurements summary, including some final and some preliminary results.

  10. Effects of pirenzepine ophthalmic solution on form-deprivation myopia in the guinea pigs

    Institute of Scientific and Technical Information of China (English)

    LE Qi-hua; CHENG Neng-neng; WU Wei; CHU Ren-yuan

    2005-01-01

    Background Nonselective muscarinic receptor antagonist, atropine, was believed to inhibit myopic progression. The purpose of this study was to determine the efficacy, through topical administration, of the M1-selective muscarinic antagonist pirenzepine in preventing experimentally induced form-deprivation myopia in guinea pigs.Methods Fifty-three guinea pigs, which underwent monocular deprivation with their eyelids sutured, were divided into 6 groups. Three groups were treated with 1%, 2% or 4% pirenzepine ophthalmic solutions; the fourth group with atropine; the fifth with saline and the last group left untreated. Ocular refraction, in vivo biometric measurements and wet eye weight were collected before and after the experiment. All the eyes were finally enucleated for histopathological examination to evaluate the possible toxic effects on ocular structures.Results Animals untreated or treated with saline produced (-2.31±1.47) D and (-2.25±0.88) D of axial myopia respectively. Those treated with 1% pirenzepine ophthalmic solution produced relative myopia of (-1.63±0.48) D, and those under the treatment of 2% and 4% pirenzepine ophthalmic solution only developed a relative myopia of (-0.89±0.42) D and (-0.70±0.41) D (F=9.56, P<0.05). The significant reduction in myopia in 2% and 4% pirenzepine treated animals was caused by significantly less vitreous chamber elongation and axial elongation of the deprived eyes [2% group: (0.009±0.052) mm, 4% group: (0.006±0.078) mm] when compared with untreated, saline treated or 1% pirenzepine treated guinea pigs [(0.057±0.056) mm, (0.064±0.053) mm and (0.033±0.035) mm, respectively]. Histological examinations revealed no obviously toxic effects on the eyes treated with pirenzepine.Conclusion Topical administration of the M1-selective muscarinic antagonist, pirenzepine, can prevent induced form-deprivation myopia in guinea pigs by inhibiting axial elongation without obvious damage to ocular tissues.

  11. MD5算法在Web开发中的应用%Application of MD5 in Web Exploitation

    Institute of Scientific and Technical Information of China (English)

    刘啸

    2014-01-01

    介绍了MD5加密技术在Web上的一些应用,给出了MD5加密实现密码在internet上安全传输的完整解决办法,给出了客户端(JavaScript)和服务器端(JavaBeans) MD5算法的实现.

  12. Intermittent exotropia: comparative surgical results of lateral recti-recession and monocular recess-resect Exotropia intermitente: comparação dos resultados cirúrgicos entre retrocesso dos retos laterais e retrocesso-ressecção monocular

    Directory of Open Access Journals (Sweden)

    Vanessa Macedo Batista Fiorelli

    2007-06-01

    Full Text Available PURPOSE: To compare the results between recession of the lateral recti and monocular recess-resect procedure for the correction of the basic type of intermittent exotropia. METHODS: 115 patients with intermittent exotropia were submitted to surgery. The patients were divided into 4 groups, according to the magnitude of preoperative deviation and the surgical procedure was subsequently performed. Well compensated orthophoria or exo-or esophoria were considered surgical success, with minimum of 1 year follow-up after the operation. RESULTS: Success was obtained in 69% of the patients submitted to recession of the lateral recti, and in 77% submitted to monocular recess-resect. In the groups with deviations between 12 PD and 25 PD, surgical success was observed in 74% of the patients submitted to recession of the lateral recti and in 78% of the patients submitted to monocular recess-resect. (p=0.564. In the group with deviations between 26 PD and 35 PD, surgical success was observed in 65% out of the patients submitted to recession of the lateral recti and in 75% of the patients submitted to monocular recess-resect. (p=0.266. CONCLUSION: recession of lateral recti and monocular recess-resect were equally effective in correcting basic type intermittent exotropia according to its preoperative deviation in primary position.OBJETIVO: Comparar os resultados entre o retrocesso dos retos laterais e retrocesso-ressecção monocular, para correção de exotropia intermitente do tipo básico. MÉTODOS: Foram selecionados 115 prontuários de pacientes portadores de exotropia intermitente do tipo básico submetidos a cirurgia no período entre janeiro de 1991 e dezembro de 2001. Os planejamentos cirúrgicos seguiram orientação do setor de Motilidade Extrínseca Ocular da Clínica Oftalmológica da Santa Casa de São Paulo e basearam-se na magnitude do desvio na posição primária do olhar. Os pacientes foram divididos em 4 grupos, de acordo com a magnitude

  13. Quetiapine treatment reverses depressive-like behavior and reduces DNA methyltransferase activity induced by maternal deprivation.

    Science.gov (United States)

    Ignácio, Zuleide M; Réus, Gislaine Z; Abelaira, Helena M; Maciel, Amanda L; de Moura, Airam B; Matos, Danyela; Demo, Júlia P; da Silva, Júlia B I; Gava, Fernanda F; Valvassori, Samira S; Carvalho, André F; Quevedo, João

    2017-03-01

    Stress in early life has been appointed as an important phenomenon in the onset of depression and poor response to treatment with classical antidepressants. Furthermore, childhood trauma triggers epigenetic changes, which are associated with the pathophysiology of major depressive disorder (MDD). Treatment with atypical antipsychotics such as quetiapine, exerts therapeutic effect for MDD patients and induces epigenetic changes. This study aimed to analyze the effect of chronic treatment with quetiapine (20mg/kg) on depressive-like behavior of rats submitted to maternal deprivation (MD), as well as the activity of histone acetylation by the enzymes histone acetyl transferases (HAT) and deacetylases (HDAC) and DNA methylation, through DNA methyltransferase enzyme (DNMT) in the prefrontal cortex (PFC), nucleus accumbens (NAc) and hippocampus. Maternally deprived rats had a depressive-like behavior in the forced swimming test and an increase in the HDAC and DNMT activities in the hippocampus and NAc. Treatment with quetiapine reversed depressive-like behavior and reduced the DNMT activity in the hippocampus. This is the first study to show the antidepressant-like effect of quetiapine in animals subjected to MD and a protective effect by quetiapine in reducing epigenetic changes induced by stress in early life. These results reinforce an important role of quetiapine as therapy for MDD. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. LHC MD 1279: Bunch Flattening in Physics

    CERN Document Server

    AUTHOR|(CDS)2073675; Baudrenghien, Philippe; Esteban Muller, Juan; Shaposhnikova, Elena; CERN. Geneva. ATS Department

    2017-01-01

    Vertex reconstruction is not accurate enough for LHCb when the bunch length in physics shrinks below about 0.9 ns. The end-of-fill MD studies presented here proved that bunch flattening using sinusoidal RF modulation is a loss-free method to increase the r.m.s. bunch length and flatten the bunch profile. Furthermore, the optimum modulation parameters to be used in physics have been identified. Subsequently, bunch flattening in physics was used operationally with a modulation frequency of 98.75 % of the central synchrotron frequency and 0.6 modulation amplitude, resulting in a 150-200 ps increase in the BQM-measured bunch length. A ‘mid-of-fill’ test at arrival to flat top revealed that also the bunch distribution created by the controlled emittance blow-up during the ramp is affected when bunch flattening is applied. The measurements took place on 17th June and the 4th, 7th and 22nd July 2016. Operational cases are shown as well.

  15. Leroy D Vandam, MD: an anesthesia journey.

    Science.gov (United States)

    Ortega, Rafael A

    2005-08-01

    Leroy D Vandam, MD was a remarkable man--an intricate amalgamation of an artist, scientist, and physician. He was a bastion of medical historical knowledge. Dr Vandam became a most influential anesthesiologist, some say, a giant. He was an example of someone who, with resolve, overcame adversity. His artwork is displayed in countless places, and several of his paintings form part of the Wood Library Museum Heritage Series. Dr Vandam was first a surgeon, but he abandoned surgery and pursued a career in anesthesiology under the leadership of Robert Dripps. He completed his residency training at the University of Pennsylvania and joined its staff in 1949. When he arrived at Brigham and Women's Hospital in the 1950s as director of anesthesia, he embarked on one of the most illustrious careers in American anesthesiology. Dr Vandam published more than 250 original articles, chapters, abstracts, and other reports on a wide variety of subjects including history, art, and pharmacology. His classic article on the complications of neuroaxial blocks is a seminal work in anesthesiology. This article describes how an anesthesiologist who shared an interest with Dr Vandam in the history of anesthesiology came to produce a movie based on his career, the evolution of anesthesia equipment, and the transformation of our specialty.

  16. Orbit Feedback Operation with RCBX (MD 1209)

    CERN Document Server

    Wenninger, Jorg; Nisbet, David; Ponce, Laurette; Louro Alves, Diogo Miguel; CERN. Geneva. ATS Department

    2017-01-01

    The LHC Orbit Feedback (OFB) is able to drive any orbit corrector circuit (COD) to steer the LHC orbit. But during the first feedback tests in 2010, all attempts to use the common triplet orbit correctors (MCBX) failed because the QPS system installed to protect those magnets triggered power aborts as soon as the OFB steered the beam with those CODs. The reason was most likely the violation of the RCBX circuit acceleration limits. For this reason the MCBX orbit correctors were never driven by the OFB in regular operation. Although the performance of the OFB is generally excellent, the quality of the beam steering around IRs could be improved if the OFB could correct the orbit with the MCBX to counteract locally triplet quadrupole movements. The aim of this MD was to make a new attempt to use the MCBX in the OFB. The test was successful at injection (no circuit trip) and failed during the ramp (QPS power abort). The PC voltages and QPS Ures signals revealed the presence of voltage spikes with a period of 10~s...

  17. The perceived visual direction of monocular objects in random-dot stereograms is influenced by perceived depth and allelotropia.

    Science.gov (United States)

    Hariharan-Vilupuru, Srividhya; Bedell, Harold E

    2009-01-01

    The proposed influence of objects that are visible to both eyes on the perceived direction of an object that is seen by only one eye is known as the "capture of binocular visual direction". The purpose of this study was to evaluate whether stereoscopic depth perception is necessary for the "capture of binocular visual direction" to occur. In one pair of experiments, perceived alignment between two nearby monocular lines changed systematically with the magnitude and direction of horizontal but not vertical disparity. In four of the five observers, the effect of horizontal disparity on perceived alignment depended on which eye viewed the monocular lines. In additional experiments, the perceived alignment between the monocular lines changed systematically with the magnitude and direction of both horizontal and vertical disparities when the monocular line separation was increased from 1.1 degrees to 3.3 degrees . These results indicate that binocular capture depends on the perceived depth that results from horizontal retinal image disparity as well as allelotropia, or the averaging of local-sign information. Our data suggest that, during averaging, different weights are afforded to the local-sign information in the two eyes, depending on whether the separation between binocularly viewed targets is horizontal or vertical.

  18. Measuring perceived depth in natural images and study of its relation with monocular and binocular depth cues

    Science.gov (United States)

    Lebreton, Pierre; Raake, Alexander; Barkowsky, Marcus; Le Callet, Patrick

    2014-03-01

    The perception of depth in images and video sequences is based on different depth cues. Studies have considered depth perception threshold as a function of viewing distance (Cutting and Vishton, 1995), the combination of different monocular depth cues and their quantitative relation with binocular depth cues and their different possible type of interactions (Landy, l995). But these studies only consider artificial stimuli and none of them attempts to provide a quantitative contribution of monocular and binocular depth cues compared to each other in the specific context of natural images. This study targets this particular application case. The evaluation of the strength of different depth cues compared to each other using a carefully designed image database to cover as much as possible different combinations of monocular (linear perspective, texture gradient, relative size and defocus blur) and binocular depth cues. The 200 images were evaluated in two distinct subjective experiments to evaluate separately perceived depth and different monocular depth cues. The methodology and the description of the definition of the different scales will be detailed. The image database (DC3Dimg) is also released for the scientific community.

  19. Monocular SLAM for Visual Odometry: A Full Approach to the Delayed Inverse-Depth Feature Initialization Method

    Directory of Open Access Journals (Sweden)

    Rodrigo Munguía

    2012-01-01

    Full Text Available This paper describes in a detailed manner a method to implement a simultaneous localization and mapping (SLAM system based on monocular vision for applications of visual odometry, appearance-based sensing, and emulation of range-bearing measurements. SLAM techniques are required to operate mobile robots in a priori unknown environments using only on-board sensors to simultaneously build a map of their surroundings; this map will be needed for the robot to track its position. In this context, the 6-DOF (degree of freedom monocular camera case (monocular SLAM possibly represents the harder variant of SLAM. In monocular SLAM, a single camera, which is freely moving through its environment, represents the sole sensory input to the system. The method proposed in this paper is based on a technique called delayed inverse-depth feature initialization, which is intended to initialize new visual features on the system. In this work, detailed formulation, extended discussions, and experiments with real data are presented in order to validate and to show the performance of the proposal.

  20. The Effect of Long Term Monocular Occlusion on Vernier Threshold: Elasticity in the Young Adult Visual System.

    Science.gov (United States)

    1986-06-01

    experiment, Brown and Salinger (1975) found a decrease of the X-cell 2 population in the lateral geniculate body of the adult cat. These investigators...D.L., and Salinger , W.L., "Loss of X-Cells in Lateral Geniculate Nucleus with Monocular Paralysis. Neural Plasticity in the Adult Cat", Science, 189

  1. Waiting time distribution in M/D/1 queueing systems

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk; Staalhagen, Lars

    1999-01-01

    The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1...

  2. BI MD studies on August 25th 2011

    CERN Document Server

    Belohrad, D; Boccardi, A; Calvo, E; Dehning, B; Favier, M; Emery, J; Guerrero, A; Lefevre, T; Gras, JJ; Jeff, A; Soby, L; Rabiller, A; Roncarolo, F; Sapinski, M; Steinhagen, R; Mateo, CM

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 25-Aug-2011 (from 5 a.m. to 1 p.m.), dedicated to study Beam Loss Monitors (BLM), Wire Scanners (WS), Synchrotron Radiation (BSRT), Beam Position Monitors (BPM), and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors.

  3. MD290: Q4 IP6 Quench Level

    CERN Document Server

    Bednarek, Mateusz Jakub; Lechner, Anton; CERN. Geneva. ATS Department

    2016-01-01

    The detailed program proposed for the LHC Machine Development concerning a quench induced by fast losses on the MQY.4L6 quadrupole is presented. The merit of the MD, the necessary modifications of the machine protection systems are presented together with a preliminary analysis of the MD results.

  4. MD5密码极速爆破

    Institute of Scientific and Technical Information of China (English)

    飘零雪

    2009-01-01

    MD5加密技术对我们来说并不陌生,通过MD5值可以校验下载软件的安全性,而且在很多系统中,用户的密码是以MD5值的方式保存的,用户登录时系统是把用户输入的密码计算成MD5值,然后再去和系统中保存的MD5值进行比较,以验证该用户的合法性。MD5值虽看似很安全,但也并非无懈可击,使用“超速md5破解工具”即可简单快捷地尝试解密MD5。

  5. Single-block collision attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security

  6. Chosen-Prefix Collisions for MD5 and Applications

    NARCIS (Netherlands)

    Stevens, M.M.J.; Lenstra, A.K.; Weger, B. de

    2012-01-01

    We present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen message prefixes $P$ and $P'$

  7. 33 CFR 110.72 - Blackhole Creek, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Blackhole Creek, Md. 110.72... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.72 Blackhole Creek, Md. The waters on the west side of Blackhole Creek, a tributary of Magothy River, southwest of a line bearing 310°30′ from the most...

  8. Sleep deprivation affects reactivity to positive but not negative stimuli.

    Science.gov (United States)

    Pilcher, June J; Callan, Christina; Posey, J Laura

    2015-12-01

    The current study examined the effects of partial and total sleep deprivation on emotional reactivity. Twenty-eight partially sleep-deprived participants and 31 totally sleep-deprived participants rated their valence and arousal responses to positive and negative pictures across four testing sessions during the day following partial sleep deprivation or during the night under total sleep deprivation. The results suggest that valence and arousal ratings decreased under both sleep deprivation conditions. In addition, partial and total sleep deprivation had a greater negative effect on positive events than negative events. These results suggest that sleep-deprived persons are more likely to respond less to positive events than negative events. One explanation for the current findings is that negative events could elicit more attentive behavior and thus stable responding under sleep deprivation conditions. As such, sleep deprivation could impact reactivity to emotional stimuli through automated attentional and self-regulatory processes. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Sleep deprivation and neurobehavioral functioning in children.

    Science.gov (United States)

    Maski, Kiran P; Kothare, Sanjeev V

    2013-08-01

    Sleep deprivation can result in significant impairments in daytime neurobehavioral functioning in children. Neural substrates impacted by sleep deprivation include the prefrontal cortex, basal ganglia and amygdala and result in difficulties with executive functioning, reward anticipation and emotional reactivity respectively. In everyday life, such difficulties contribute to academic struggles, challenging behaviors and public health concerns of substance abuse and suicidality. In this article, we aim to review 1) core neural structures impacted by sleep deprivation; 2) neurobehavioral problems associated with sleep deprivation; 3) specific mechanisms that may explain the relationship between sleep disturbances and neurobehavioral dysfunction; and 4) sleep problems reported in common neurodevelopmental disorders including attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorders (ASDs).

  10. Relative Deprivation, Poor Health Habits and Mortality

    Science.gov (United States)

    Eibner, Christine E.; Evans, William N.

    2005-01-01

    The results of the study conducted, using the data from National Health Interview Survey (NHIS) (BRFSS), to find the relationship between the relative deprivation and mortality, while controlling individual income and reference group fixed effects, are presented.

  11. Deprivation among unemployed South African youth ...

    African Journals Online (AJOL)

    are more at risk of suffering deprivation .... income or consumption (in)adequacy ... capital accessibility and education as ... one of the poverty reduction strategies, .... regarding how far off households are from the poverty line (World Bank, ...

  12. SOCIODEMOGRAPHIC DOMAINS OF DEPRIVATION AND PRETERM BIRTH

    Science.gov (United States)

    Area-level deprivation is consistently associated with poor health outcomes. Using US census data (2000) and principal components analysis, a priori defined socio-demographic indices of poverty, housing, residential stability, occupation, employment and education were created fo...

  13. Deprivation, HIV and AIDS in Northern Uganda

    African Journals Online (AJOL)

    Key Words: HIV & AIDS, Deprivation, Susceptibility, Vulnerability, Deaths, IDP camps, .... Uganda Peoples Defence Forces (UPDF), the Police and Local Defense .... on-going, northern Uganda is only included in the Rural Finance Service ...

  14. The effects of total sleep deprivation on Bayesian updating

    OpenAIRE

    Dickinson, David L.; Drummond, Sean P.A.

    2008-01-01

    Recent evidence suggests that nearly 25% of U.S. adults (47 million) suffer from some level of sleep deprivation. The impact of this sleep deprivation on the U.S. economy includes direct medical expenses related to sleep deprivation and related disorders, the cost of accidents, and the cost of reduced worker productivity. Sleep research has examined the effects of sleep deprivation on a number of performance measures, but the effects of sleep deprivation on decision-making under uncertainty a...

  15. Deprived or not deprived? Comparing the measured extent of material deprivation using the UK government's and the Poverty and Social Exclusion surveys' method of calculating material deprivation

    OpenAIRE

    Treanor, Morag C

    2014-01-01

    Poverty can either be measured directly, through standards of living such as material deprivation, or indirectly through resources available, usually income. Research shows that the optimum measure of poverty combines these methods, a fact that the UK government took cognisance of in its tripartite measure of child poverty. For use in a birth cohort study, two methods of calculating material deprivation were tested: the method used by the UK government taken from the Family Resources Survey (...

  16. Relative deprivation and mortality in South Africa.

    Science.gov (United States)

    Salti, Nisreen

    2010-03-01

    This paper tests the relative income hypothesis by considering the relationship between mortality, income and relative deprivation in South Africa using individual-level data on income and five measures of relative deprivation each with a different reference group. We find that income tends to be protective of, and relative deprivation detrimental to health, but the latter often gives a better account of mortality than does income alone. For some population groups the fit is improved in specifications which include both income and relative deprivation. Overall, there seems to be solid evidence in support of the relative income hypothesis, particularly for the more economically disadvantaged population groups. Relative deprivation is especially significant when age is the reference group, suggesting that the comparison of socio-economic standing that has an impact on health tends to happen within cohorts. The results are robust to splitting the sample into urban/rural subsamples and to looking at the incidence of illness as the health outcome rather than mortality. While little is known about the mechanisms underlying the effect of relative deprivation on health and mortality, the consistent evidence in favor of age as a reference group, particularly in a context like South Africa's suggests that intra-cohort comparisons should be an avenue for more in depth investigation. 2009 Elsevier Ltd. All rights reserved.

  17. Prostate Cancer Severity Associations with Neighborhood Deprivation

    Directory of Open Access Journals (Sweden)

    Charnita M. Zeigler-Johnson

    2011-01-01

    Full Text Available Background. The goal of this paper was to examine neighborhood deprivation and prostate cancer severity. Methods. We studied African American and Caucasian prostate cancer cases from the Pennsylvania State Cancer Registry. Census tract-level variables and deprivation scores were examined in relation to diagnosis stage, grade, and tumor aggressiveness. Results. We observed associations of low SES with high Gleason score among African Americans residing in neighborhoods with low educational attainment (OR = 1.34, 95% CI = 1.13–1.60, high poverty (OR = 1.39, 95% CI = 1.15–1.67, low car ownership (OR = 1.46, 95% CI = 1.20–1.78, and higher percentage of residents on public assistance (OR = 1.32, 95% = 1.08–1.62. The highest quartile of neighborhood deprivation was also associated with high Gleason score. For both Caucasians and African Americans, the highest quartile of neighborhood deprivation was associated with high Gleason score at diagnosis (OR = 1.34, 95% CI = 1.19–1.52; OR = 1.71, 95% CI = 1.21–2.40, resp.. Conclusion. Using a neighborhood deprivation index, we observed associations between high-grade prostate cancer and neighborhood deprivation in Caucasians and African-Americans.

  18. Sleep deprivation and interference by emotional distracters.

    Science.gov (United States)

    Chuah, Lisa Y M; Dolcos, Florin; Chen, Annette K; Zheng, Hui; Parimal, Sarayu; Chee, Michael W L

    2010-10-01

    We determined if sleep deprivation would amplify the effect of negative emotional distracters on working memory. A crossover design involving 2 functional neuroimaging scans conducted at least one week apart. One scan followed a normal night of sleep and the other followed 24 h of sleep deprivation. Scanning order was counterbalanced across subjects. The study took place in a research laboratory. 24 young, healthy volunteers with no history of any sleep, psychiatric, or neurologic disorders. N/A. Study participants were scanned while performing a delayed-response working memory task. Two distracters were presented during the maintenance phase, and these differed in content: highly arousing, negative emotional scenes; low-arousing, neutral scenes; and digitally scrambled versions of the pictures. Irrespective of whether volunteers were sleep deprived, negative emotional (relative to neutral) distracters elicited greater maintenance-related activity in the amygdala, ventrolateral prefrontal cortex, and fusiform gyri, while concurrently depressing activity in cognitive control regions. Individuals who maintained or increased distracter-related amygdala activation after sleep deprivation showed increased working memory disruptions by negative emotional distracters. These individuals also showed reduced functional connectivity between the amygdala and the ventromedial and dorsolateral prefrontal cortices, regions postulated to mediate cognitive control against emotional distraction. Increased distraction by emotional stimuli following sleep deprivation is accompanied by increases in amygdala activation and reduced functional connectivity between the amygdala and prefrontal cognitive control regions. These findings shed light on the neural basis for interindividual variation in how negative emotional stimuli might distract sleep deprived persons.

  19. Early maternal deprivation induces changes on the expression of 2-AG biosynthesis and degradation enzymes in neonatal rat hippocampus.

    Science.gov (United States)

    Suárez, Juan; Rivera, Patricia; Llorente, Ricardo; Romero-Zerbo, Silvana Y; Bermúdez-Silva, Francisco J; de Fonseca, Fernando Rodríguez; Viveros, María-Paz

    2010-08-19

    Early maternal deprivation (MD) in rats (24h, PND 9-10) is a model for neurodevelopmental stress. Our previous data showed that MD altered the hippocampal levels of the endocannabinoid 2-AG and the expression of hippocampal cannabinoid receptors in 13-day-old rats, with males being more markedly affected. The aim of this study was to analyze the impact of MD on the enzymes involved in 2-AG biosynthesis (DAGLalpha and DAGLbeta) and degradation (MAGL) in relevant areas (DG, CA1, CA3) of the hippocampus in 13-day-old neonatal rats. The expression of the enzymes was evaluated by quantitative RT-PCR, immunohistochemistry, and densitometry. MD induced a significant increase in DAGLalpha immunoreactivity in both males and females, which was mainly associated with fibers in the polymorphic cell layer of the dentate gyrus and in the stratum pyramidale of CA3. In contrast, the molecular layer of the dentate gyrus showed a significant decrease in DAGLalpha immunoreactivity in MD males and females. No changes were observed in DAGLbeta immunoreactivity. MD induced a significant decrease in MAGL immunoreactivity in hippocampal CA3 and CA1 areas, more marked in males than in females, and that was mainly associated with fibers in all strata of CA3 and CA1. The results also showed a significant decrease of MAGL mRNA levels in MD males. These data support a clear association between neurodevelopmental stress and dysregulation of the endocannabinoid system. This association may be relevant for schizophrenia and other neurodevelopmental psychiatric disorders.

  20. Accurate and Robust Attitude Estimation Using MEMS Gyroscopes and a Monocular Camera

    Science.gov (United States)

    Kobori, Norimasa; Deguchi, Daisuke; Takahashi, Tomokazu; Ide, Ichiro; Murase, Hiroshi

    In order to estimate accurate rotations of mobile robots and vehicle, we propose a hybrid system which combines a low-cost monocular camera with gyro sensors. Gyro sensors have drift errors that accumulate over time. On the other hand, a camera cannot obtain the rotation continuously in the case where feature points cannot be extracted from images, although the accuracy is better than gyro sensors. To solve these problems we propose a method for combining these sensors based on Extended Kalman Filter. The errors of the gyro sensors are corrected by referring to the rotations obtained from the camera. In addition, by using the reliability judgment of camera rotations and devising the state value of the Extended Kalman Filter, even when the rotation is not continuously observable from the camera, the proposed method shows a good performance. Experimental results showed the effectiveness of the proposed method.

  1. Extracting hand articulations from monocular depth images using curvature scale space descriptors

    Institute of Scientific and Technical Information of China (English)

    Shao-fan WANG[1; Chun LI[1; De-hui KONG[1; Bao-cai YIN[2,1,3

    2016-01-01

    We propose a framework of hand articulation detection from a monocular depth image using curvature scale space (CSS) descriptors. We extract the hand contour from an input depth image, and obtain the fingertips and finger-valleys of the contour using the local extrema of a modified CSS map of the contour. Then we recover the undetected fingertips according to the local change of depths of points in the interior of the contour. Compared with traditional appearance-based approaches using either angle detectors or convex hull detectors, the modified CSS descriptor extracts the fingertips and finger-valleys more precisely since it is more robust to noisy or corrupted data; moreover, the local extrema of depths recover the fingertips of bending fingers well while traditional appearance-based approaches hardly work without matching models of hands. Experimental results show that our method captures the hand articulations more precisely compared with three state-of-the-art appearance-based approaches.

  2. Extracting hand articulations from monocular depth images using curvature scale space descriptors

    Institute of Scientific and Technical Information of China (English)

    Shao-fan WANG; Chun LI; De-hui KONG; Bao-cai YIN

    2016-01-01

    We propose a framework of hand articulation detection from a monocular depth image using curvature scale space (CSS) descriptors. We extract the hand contour from an input depth image, and obtain the fingertips and finger-valleys of the contour using the local extrema of a modified CSS map of the contour. Then we recover the undetected fingertips according to the local change of depths of points in the interior of the contour. Compared with traditional appearance-based approaches using either angle detectors or convex hull detectors, the modified CSS descriptor extracts the fingertips and finger-valleys more precisely since it is more robust to noisy or corrupted data;moreover, the local extrema of depths recover the fingertips of bending fingers well while traditional appearance-based approaches hardly work without matching models of hands. Experimental results show that our method captures the hand articulations more precisely compared with three state-of-the-art appearance-based approaches.

  3. Mobile Robot Simultaneous Localization and Mapping Based on a Monocular Camera

    Directory of Open Access Journals (Sweden)

    Songmin Jia

    2016-01-01

    Full Text Available This paper proposes a novel monocular vision-based SLAM (Simultaneous Localization and Mapping algorithm for mobile robot. In this proposed method, the tracking and mapping procedures are split into two separate tasks and performed in parallel threads. In the tracking thread, a ground feature-based pose estimation method is employed to initialize the algorithm for the constraint moving of the mobile robot. And an initial map is built by triangulating the matched features for further tracking procedure. In the mapping thread, an epipolar searching procedure is utilized for finding the matching features. A homography-based outlier rejection method is adopted for rejecting the mismatched features. The indoor experimental results demonstrate that the proposed algorithm has a great performance on map building and verify the feasibility and effectiveness of the proposed algorithm.

  4. Navigation system for a small size lunar exploration rover with a monocular omnidirectional camera

    Science.gov (United States)

    Laîné, Mickaël.; Cruciani, Silvia; Palazzolo, Emanuele; Britton, Nathan J.; Cavarelli, Xavier; Yoshida, Kazuya

    2016-07-01

    A lunar rover requires an accurate localisation system in order to operate in an uninhabited environment. However, every additional piece of equipment mounted on it drastically increases the overall cost of the mission. This paper reports a possible solution for a micro-rover using a sole monocular omnidirectional camera. Our approach relies on a combination of feature tracking and template matching for Visual Odometry. The results are afterwards refined using a Graph-Based SLAM algorithm, which also provides a sparse reconstruction of the terrain. We tested the algorithm on a lunar rover prototype in a lunar analogue environment and the experiments show that the estimated trajectory is accurate and the combination with the template matching algorithm allows an otherwise poor detection of spot turns.

  5. The effect of monocular depth cues on the detection of moving objects by moving observers.

    Science.gov (United States)

    Royden, Constance S; Parsons, Daniel; Travatello, Joshua

    2016-07-01

    An observer moving through the world must be able to identify and locate moving objects in the scene. In principle, one could accomplish this task by detecting object images moving at a different angle or speed than the images of other items in the optic flow field. While angle of motion provides an unambiguous cue that an object is moving relative to other items in the scene, a difference in speed could be due to a difference in the depth of the objects and thus is an ambiguous cue. We tested whether the addition of information about the distance of objects from the observer, in the form of monocular depth cues, aided detection of moving objects. We found that thresholds for detection of object motion decreased as we increased the number of depth cues available to the observer.

  6. A method of real-time detection for distant moving obstacles by monocular vision

    Science.gov (United States)

    Jia, Bao-zhi; Zhu, Ming

    2013-12-01

    In this paper, we propose an approach for detection of distant moving obstacles like cars and bicycles by a monocular camera to cooperate with ultrasonic sensors in low-cost condition. We are aiming at detecting distant obstacles that move toward our autonomous navigation car in order to give alarm and keep away from them. Method of frame differencing is applied to find obstacles after compensation of camera's ego-motion. Meanwhile, each obstacle is separated from others in an independent area and given a confidence level to indicate whether it is coming closer. The results on an open dataset and our own autonomous navigation car have proved that the method is effective for detection of distant moving obstacles in real-time.

  7. Detection and Tracking Strategies for Autonomous Aerial Refuelling Tasks Based on Monocular Vision

    Directory of Open Access Journals (Sweden)

    Yingjie Yin

    2014-07-01

    Full Text Available Detection and tracking strategies based on monocular vision are proposed for autonomous aerial refuelling tasks. The drogue attached to the fuel tanker aircraft has two important features. The grey values of the drogue's inner part are different from the external umbrella ribs, as shown in the image. The shape of the drogue's inner dark part is nearly circular. According to crucial prior knowledge, the rough and fine positioning algorithms are designed to detect the drogue. Particle filter based on the drogue's shape is proposed to track the drogue. A strategy to switch between detection and tracking is proposed to improve the robustness of the algorithms. The inner dark part of the drogue is segmented precisely in the detecting and tracking process and the segmented circular part can be used to measure its spatial position. The experimental results show that the proposed method has good performance in real-time and satisfied robustness and positioning accuracy.

  8. Robust Range Estimation with a Monocular Camera for Vision-Based Forward Collision Warning System

    Directory of Open Access Journals (Sweden)

    Ki-Yeong Park

    2014-01-01

    Full Text Available We propose a range estimation method for vision-based forward collision warning systems with a monocular camera. To solve the problem of variation of camera pitch angle due to vehicle motion and road inclination, the proposed method estimates virtual horizon from size and position of vehicles in captured image at run-time. The proposed method provides robust results even when road inclination varies continuously on hilly roads or lane markings are not seen on crowded roads. For experiments, a vision-based forward collision warning system has been implemented and the proposed method is evaluated with video clips recorded in highway and urban traffic environments. Virtual horizons estimated by the proposed method are compared with horizons manually identified, and estimated ranges are compared with measured ranges. Experimental results confirm that the proposed method provides robust results both in highway and in urban traffic environments.

  9. Indoor Mobile Robot Navigation by Central Following Based on Monocular Vision

    Science.gov (United States)

    Saitoh, Takeshi; Tada, Naoya; Konishi, Ryosuke

    This paper develops the indoor mobile robot navigation by center following based on monocular vision. In our method, based on the frontal image, two boundary lines between the wall and baseboard are detected. Then, the appearance based obstacle detection is applied. When the obstacle exists, the avoidance or stop movement is worked according to the size and position of the obstacle, and when the obstacle does not exist, the robot moves at the center of the corridor. We developed the wheelchair based mobile robot. We estimated the accuracy of the boundary line detection, and obtained fast processing speed and high detection accuracy. We demonstrate the effectiveness of our mobile robot by the stopping experiments with various obstacles and moving experiments.

  10. Real Time 3D Facial Movement Tracking Using a Monocular Camera.

    Science.gov (United States)

    Dong, Yanchao; Wang, Yanming; Yue, Jiguang; Hu, Zhencheng

    2016-07-25

    The paper proposes a robust framework for 3D facial movement tracking in real time using a monocular camera. It is designed to estimate the 3D face pose and local facial animation such as eyelid movement and mouth movement. The framework firstly utilizes the Discriminative Shape Regression method to locate the facial feature points on the 2D image and fuses the 2D data with a 3D face model using Extended Kalman Filter to yield 3D facial movement information. An alternating optimizing strategy is adopted to fit to different persons automatically. Experiments show that the proposed framework could track the 3D facial movement across various poses and illumination conditions. Given the real face scale the framework could track the eyelid with an error of 1 mm and mouth with an error of 2 mm. The tracking result is reliable for expression analysis or mental state inference.

  11. Comparative evaluation of monocular augmented-reality display for surgical microscopes.

    Science.gov (United States)

    Rodriguez Palma, Santiago; Becker, Brian C; Lobes, Louis A; Riviere, Cameron N

    2012-01-01

    Medical augmented reality has undergone much development recently. However, there is a lack of studies quantitatively comparing the different display options available. This paper compares the effects of different graphical overlay systems in a simple micromanipulation task with "soft" visual servoing. We compared positioning accuracy in a real-time visually-guided task using Micron, an active handheld tremor-canceling microsurgical instrument, using three different displays: 2D screen, 3D screen, and microscope with monocular image injection. Tested with novices and an experienced vitreoretinal surgeon, display of virtual cues in the microscope via an augmented reality injection system significantly decreased 3D error (p < 0.05) compared to the 2D and 3D monitors when confounding factors such as magnification level were normalized.

  12. A Robust Approach for a Filter-Based Monocular Simultaneous Localization and Mapping (SLAM System

    Directory of Open Access Journals (Sweden)

    Antoni Grau

    2013-07-01

    Full Text Available Simultaneous localization and mapping (SLAM is an important problem to solve in robotics theory in order to build truly autonomous mobile robots. This work presents a novel method for implementing a SLAM system based on a single camera sensor. The SLAM with a single camera, or monocular SLAM, is probably one of the most complex SLAM variants. In this case, a single camera, which is freely moving through its environment, represents the sole sensor input to the system. The sensors have a large impact on the algorithm used for SLAM. Cameras are used more frequently, because they provide a lot of information and are well adapted for embedded systems: they are light, cheap and power-saving. Nevertheless, and unlike range sensors, which provide range and angular information, a camera is a projective sensor providing only angular measurements of image features. Therefore, depth information (range cannot be obtained in a single step. In this case, special techniques for feature system-initialization are needed in order to enable the use of angular sensors (as cameras in SLAM systems. The main contribution of this work is to present a novel and robust scheme for incorporating and measuring visual features in filtering-based monocular SLAM systems. The proposed method is based in a two-step technique, which is intended to exploit all the information available in angular measurements. Unlike previous schemes, the values of parameters used by the initialization technique are derived directly from the sensor characteristics, thus simplifying the tuning of the system. The experimental results show that the proposed method surpasses the performance of previous schemes.

  13. A robust approach for a filter-based monocular simultaneous localization and mapping (SLAM) system.

    Science.gov (United States)

    Munguía, Rodrigo; Castillo-Toledo, Bernardino; Grau, Antoni

    2013-07-03

    Simultaneous localization and mapping (SLAM) is an important problem to solve in robotics theory in order to build truly autonomous mobile robots. This work presents a novel method for implementing a SLAM system based on a single camera sensor. The SLAM with a single camera, or monocular SLAM, is probably one of the most complex SLAM variants. In this case, a single camera, which is freely moving through its environment, represents the sole sensor input to the system. The sensors have a large impact on the algorithm used for SLAM. Cameras are used more frequently, because they provide a lot of information and are well adapted for embedded systems: they are light, cheap and power-saving. Nevertheless, and unlike range sensors, which provide range and angular information, a camera is a projective sensor providing only angular measurements of image features. Therefore, depth information (range) cannot be obtained in a single step. In this case, special techniques for feature system-initialization are needed in order to enable the use of angular sensors (as cameras) in SLAM systems. The main contribution of this work is to present a novel and robust scheme for incorporating and measuring visual features in filtering-based monocular SLAM systems. The proposed method is based in a two-step technique, which is intended to exploit all the information available in angular measurements. Unlike previous schemes, the values of parameters used by the initialization technique are derived directly from the sensor characteristics, thus simplifying the tuning of the system. The experimental results show that the proposed method surpasses the performance of previous schemes.

  14. c-FOS expression in the visual system of tree shrews after monocular inactivation.

    Science.gov (United States)

    Takahata, Toru; Kaas, Jon H

    2017-01-01

    Tree shrews possess an unusual segregation of ocular inputs to sublayers rather than columns in the primary visual cortex (V1). In this study, the lateral geniculate nucleus (LGN), superior colliculus (SC), pulvinar, and V1 were examined for changes in c-FOS, an immediate-early gene, expression after 1 or 24 hours of monocular inactivation with tetrodotoxin (TTX) in tree shrews. Monocular inactivation greatly reduced gene expression in LGN layers related to the blocked eye, whereas normally high to moderate levels were maintained in the layers that receive inputs from the intact eye. The SC and caudal pulvinar contralateral to the blocked eye had greatly (SC) or moderately (pulvinar) reduced gene expressions reflective of dependence on the contralateral eye. c-FOS expression in V1 was greatly reduced contralateral to the blocked eye, with most of the expression that remained in upper layer 4a and lower 4b and lower layer 6 regions. In contrast, much of V1 contralateral to the active eye showed normal levels of c-FOS expression, including the inner parts of sublayers 4a and 4b and layers 2, 3, and 6. In some cases, upper layer 4a and lower 4b showed a reduction of gene expression. Layers 5 and sublayer 3c had normally low levels of gene expression. The results reveal the functional dominance of the contralateral eye in activating the SC, pulvinar, and V1, and the results from V1 suggest that the sublaminar organization of layer 4 is more complex than previously realized. J. Comp. Neurol. 525:151-165, 2017. © 2016 Wiley Periodicals, Inc.

  15. MD-PhD training: looking back and looking forward.

    Science.gov (United States)

    Bonham, Ann C

    2014-01-01

    MD-PhD programs provide rigorous, integrated training for physician-scientists, enabling them to frame scientific questions in unique ways and to apply clinical insight to fundamental science. Few would question the influential contributions of MD-PhD physician-scientists in advancing medical science. In this issue of Academic Medicine, Jeffe et al affirm high levels of excellence in educational outcomes from MD-PhD training programs at U.S. MD-granting medical schools, especially programs that receive funding from the NIH Medical Scientist Training Program (MSTP). The author of this commentary observes that, in the face of current economic pressures, comprehensive, longitudinal national outcomes data from MSTP- and non-MSTP-funded MD-PhD programs will help verify the value provided by MD-PhD physician-scientists. She proposes that MD-PhD programs should better prepare the next generation of physician-scientists for future research environments, which will provide new technologies, venues, and modalities. These research environments will be more closely integrated within health care delivery systems, extend into diverse communities and regions, and employ complex technologies. MD-PhD physician-scientists also will train and gain expertise in broadening areas of research, such as health policy, health economics, clinical epidemiology, and medical informatics. Program leaders are ideally situated to foster innovative learning environments and methodologies. By sharing their innovations, they can help ensure production of a diverse MD-PhD physician-scientist workforce, prepared to engage in myriad research opportunities to meet patient and population needs in a new environment.

  16. MD5加密算法的研究

    Institute of Scientific and Technical Information of China (English)

    许琪

    2014-01-01

    MD5加密算法做为散列函数的一个重要算法,在文件校验、数字签名等诸多领域有着广泛的应用.虽然MD5加密算法是单向算法,但其仍无法抵御差分攻击和查字典攻击.文章在分析了差分攻击原理的基础上,阐述了MD5加密算法采用差分攻击产生碰撞的方法.

  17. The Achromatic Telescopic Squeezing (ATS) MD part III

    CERN Document Server

    Fartoukh, S; Goddard, B; Hofle, W; Jacquet, D; Kruk, G; Lamont, M; de Maria, R; Miyamoto, R; Mueller, G; Pojer, M; Ponce, L; Redaelli, S; Ryckx, N; Steinhagen, R; Strzelczyk, M; Vanbavinckhove, G; Wenninger, J

    2011-01-01

    This note highlights the results obtained during the third so-called ATS MD which took place in 2011. The goal of this MD was extremely challenging, targeting a pre-squeezed beta* of 40 cm in ATLAS and CMS, followed by a telescopic squeeze of these two insertions to finally reach a beta* of 10 cm both at IP1 and IP5. Due to the rather poor machine availability during the MD period, the time initially allocated to the ATS studies was hardly cut by a factor of 2, and "only" the achromatic pre-squeeze down to beta*=40 cm was demonstrated with beam.

  18. MD5Hash加密算法在SQL Server2005中的应用%Application of MD5 Hash Encryption Algorithm in SQL Server 2005

    Institute of Scientific and Technical Information of China (English)

    李红日

    2011-01-01

    在对MD5算法进行简要描述的同时,对MD5算法的原理作深入分析.介绍在C创建MD5 Hash算法的函数,在SQL Server中应用MD5哈希算法,并且经过测试可以准确实现MD5 Hash加密算法.

  19. Monocular discs in the occlusion zones of binocular surfaces do not have quantitative depth--a comparison with Panum's limiting case.

    Science.gov (United States)

    Gillam, Barbara; Cook, Michael; Blackburn, Shane

    2003-01-01

    Da Vinci stereopsis is defined as apparent depth seen in a monocular object laterally adjacent to a binocular surface in a position consistent with its occlusion by the other eye. It is widely regarded as a new form of quantitative stereopsis because the depth seen is quantitatively related to the lateral separation of the monocular element and the binocular surface (Nakayama and Shimojo 1990 Vision Research 30 1811-1825). This can be predicted on the basis that the more separated the monocular element is from the surface the greater its minimum depth behind the surface would have to be to account for its monocular occlusion. Supporting evidence, however, has used narrow bars as the monocular elements, raising the possibility that quantitative depth as a function of separation could be attributable to Panum's limiting case (double fusion) rather than to a new form of stereopsis. We compared the depth performance of monocular objects fusible with the edge of the surface in the contralateral eye (lines) and non-fusible objects (disks) and found that, although the fusible objects showed highly quantitative depth, the disks did not, appearing behind the surface to the same degree at all separations from it. These findings indicate that, although there is a crude sense of depth for discrete monocular objects placed in a valid position for uniocular occlusion, depth is not quantitative. They also indicate that Panum's limiting case is not, as has sometimes been claimed, itself a case of da Vinci stereopsis since fusibility is a critical factor for seeing quantitative depth in discrete monocular objects relative to a binocular surface.

  20. The maternal deprivation animal model revisited.

    Science.gov (United States)

    Marco, Eva M; Llorente, Ricardo; López-Gallardo, Meritxell; Mela, Virginia; Llorente-Berzal, Álvaro; Prada, Carmen; Viveros, María-Paz

    2015-04-01

    Early life stress, in the form of MD (24h at pnd 9), interferes with brain developmental trajectories modifying both behavioral and neurobiochemical parameters. MD has been reported to enhance neuroendocrine responses to stress, to affect emotional behavior and to impair cognitive function. More recently, changes in body weight gain, metabolic parameters and immunological responding have also been described. Present data give support to the fact that neuronal degeneration and/or astrocyte proliferation are present in specific brain regions, mainly hippocampus, prefrontal cortex and hypothalamus, which are particularly vulnerable to the effects of neonatal stress. The MD animal model arises as a valuable tool for the investigation of the brain processes occurring at the narrow time window comprised between pnd 9 and 10 that are critical for the establishment of brain circuitries critical for the regulation of behavior, metabolism and energy homeostasis. In the present review we will discuss three possible mechanisms that might be crucial for the effects of MD, namely, the rapid increase in glucocorticoids, the lack of the neonatal leptin surge, and the enhanced endocannabinoid signaling during the specific critical period of MD. A better understanding of the mechanisms underlying the detrimental consequences of MD is a concern for public health and may provide new insights into mental health prevention strategies and into novel therapeutic approaches in neuropsychiatry.

  1. Find an Orthopaedic Foot and Ankle MD/DO

    Science.gov (United States)

    ... Content AOFAS / FootCareMD / Find a Surgeon Find an Orthopaedic Foot & Ankle Surgeon Page Content The Orthopaedic Distinction Who are Orthopaedic Foot & Ankle Surgeons? Orthopaedic foot and ankle surgeons ...

  2. Molecular Dynamics Simulations and XAFS (MD-XAFS)

    Energy Technology Data Exchange (ETDEWEB)

    Schenter, Gregory K.; Fulton, John L.

    2017-01-20

    MD-XAFS (Molecular Dynamics X-ray Adsorption Fine Structure) makes the connection between simulation techniques that generate an ensemble of molecular configurations and the direct signal observed from X-ray measurement.

  3. Interocular suppression in children with deprivation amblyopia.

    Science.gov (United States)

    Hamm, Lisa; Chen, Zidong; Li, Jinrong; Black, Joanna; Dai, Shuan; Yuan, Junpeng; Yu, Minbin; Thompson, Benjamin

    2017-04-01

    In patients with anisometropic or strabismic amblyopia, interocular suppression can be minimized by presenting high contrast stimulus elements to the amblyopic eye and lower contrast elements to the fellow eye. This suggests a structurally intact binocular visual system that is functionally suppressed. We investigated whether suppression can also be overcome by contrast balancing in children with deprivation amblyopia due to childhood cataracts. To quantify interocular contrast balance, contrast interference thresholds were measured using an established dichoptic global motion technique for 21 children with deprivation amblyopia, 14 with anisometropic or mixed strabismic/anisometropic amblyopia and 10 visually normal children (mean age mean=9.9years, range 5-16years). We found that interocular suppression could be overcome by contrast balancing in most children with deprivation amblyopia, at least intermittently, and all children with anisometropic or mixed anisometropic/strabismic amblyopia. However, children with deprivation amblyopia due to early unilateral or bilateral cataracts could tolerate only very low contrast levels to the stronger eye indicating strong suppression. Our results suggest that treatment options reliant on contrast balanced dichoptic presentation could be attempted in a subset of children with deprivation amblyopia. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Material deprivation and health: a longitudinal study.

    Science.gov (United States)

    Tøge, Anne Grete; Bell, Ruth

    2016-08-08

    Does material deprivation affect the consequences of ill health? Answering this question requires that we move beyond the effects of income. Longitudinal data on material deprivation, longstanding illness and limiting longstanding illness enables investigations of the effects of material deprivation on risk of limiting longstanding illness. This study investigates whether a shift from affording to not affording a car predicts the probability of limiting longstanding ill (LLSI). The 2008-2011 longitudinal panel of Statistics on Income, Social Inclusion and Living Conditions (EU-SILC) is utilised. Longitudinal fixed effects logit models are applied, using LLSI as dependent variable. Transition from affording a car to not affording a car is used as a proxy for material deprivation. All models are controlled for whether the person becomes longstanding ill (LSI) as well as other time-variant covariates that could affect the results. The analysis shows a statistically significant increased odds ratio of LLSI when individuals no longer can afford a car, after controlling for confounders and LSI in the previous year (1.129, CI = 1.022-1.248). However, when restricting the sample to observations where respondents report longstanding illness the results are no longer significant (1.032, CI = 0.910-1.171). The results indicate an individual level effect of material deprivation on LLSI, suggesting that material resources can affect the consequences of ill health.

  5. Personal relative deprivation, delay discounting, and gambling.

    Science.gov (United States)

    Callan, Mitchell J; Shead, N Will; Olson, James M

    2011-11-01

    Several lines of research have provided evidence for a relation between personal relative deprivation and gambling. Despite this knowledge, little is known about possible psychological mechanisms through which personal relative deprivation exerts its influence on gambling. The authors of this research sought to examine one such mechanism: the desire for immediate rewards. Using complementary approaches to studying psychological mechanisms, they tested in four studies the general hypothesis that personal relative deprivation translates into gambling urges and behavior in part via increased desires for immediate, even if smaller, rewards. Study 1 showed that an experimental manipulation of personal relative deprivation increased participants' preferences for smaller-sooner over larger-later rewards during a delay-discounting task. Studies 2 and 3 showed that a decreased willingness to delay gratification led to increased gambling behavior. Study 4 showed that preferences for smaller-sooner over larger-later rewards statistically mediated the relation between self-reported personal relative deprivation and gambling urges among a community sample of gamblers. The implications and potential applications of these findings are discussed.

  6. Analyzing the effects of a single episode of neonatal maternal deprivation on metabolite profiles in rat brain: a proton nuclear magnetic resonance spectroscopy study.

    Science.gov (United States)

    Llorente, R; Villa, P; Marco, E M; Viveros, M P

    2012-01-10

    Animal models have greatly contributed to the understanding of neuropsychiatric disorders and have provided extensive evidence for the "neurodevelopmental hypothesis." In this regard, a single and prolonged episode (24 h) of early maternal deprivation early in life, on postnatal day 9, has been proposed as an animal model for the investigation of certain neuropsychiatric disorders, including schizophrenia. Since metabolic changes in hippocampus (HIP) and prefrontal cortex (PFC) have been described among schizophrenic patients by using ex vivo high-resolution magic angle spinning (HR-MAS) proton ((1)H) nuclear magnetic resonance spectroscopy, in the present study we aimed to investigate the effects of maternal deprivation (MD) on the metabolite profiles of the developing brain by using the HR-MAS technique. MD significantly altered the hippocampal and cortical metabolic profile of neonatal rats (PND 13) in a sex-dependent manner. Glutamine and glutamate (Glx) and taurine of male and female rat pups were altered in both brain areas analyzed. Differences in hippocampal phosphorylethanolamine have also been found as a function of the MD protocol. In addition, MD induced some other region- and sex-dependent effects, including changes in N-acetyl aspartate and total choline signals in the hippocampi of male pups. Present findings indicate a different brain metabolic profile in our animal model of early life stress suggesting its potential utility in the implementation of translational neuropsychiatric research.

  7. beta* leveling with telescopic ATS squeeze (MD 2410)

    CERN Document Server

    Wenninger, Jorg; Hostettler, Michi; Pojer, Mirko; Ponce, Laurette; Tydecks, Tobias; CERN. Geneva. ATS Department

    2017-01-01

    Luminosity leveling by beta* is the baseline operational scenario of HL-LHC, and this leveling technique may be used in 2018 or during run~3 depending on the beam parameters and beta* range. During this MD beta*leveling was commissioned successfully for the first time with the telescopic squeeze over the beta* range of 40 cm to 30 cm. A novel beta* leveling controls technique based on a modification of the LSA trim was also tested during the MD.

  8. Transposição monocular vertical dos músculos retos horizontais em pacientes esotrópicos portadores de anisotropia em A Monocular vertical displacement of the horizontal rectus muscles in esotropic patients with "A" pattern

    Directory of Open Access Journals (Sweden)

    Ana Carolina Toledo Dias

    2004-10-01

    Full Text Available OBJETIVO: Estudar a eficácia da transposição vertical monocular dos mús-culos retos horizontais, proposta por Goldstein, em pacientes esotrópicos portadores de anisotropia em A, sem hiperfunção de músculos oblíquos. MÉTODOS: Foram analisados, retrospectivamente, 23 prontuários de pacientes esotrópicos portadores de anisotropia em A > 10delta, submetidos a transposição vertical monocular dos músculos retos horizontais. Os pacientes foram divididos em 2 grupos, de acordo com a magnitude da incomitância pré-operatória; grupo 1 era composto de pacientes com desvio entre 11delta e 20delta e grupo 2 entre 21delta e 30delta. Foram considerados co-mo resultados satisfatórios as correções com A PURPOSE: To report the effectiveness of the vertical monocular displacement of the horizontal rectus muscles, proposed by Goldstein, in esotropic patients with A pattern, without oblique muscle overaction. METHODS: A retrospective study was performed using the charts of 23 esotropic patients with A pattern > 10delta, submitted to vertical monocular displacement of the horizontal rectus muscles. The patients were divided into 2 groups in agreement with the magnitude of the preoperative deviation, group 1 (11delta to 20delta and group 2 (21delta to 30delta. Satisfactory results were considered when corrections A < 10delta or V < 15delta were obtained. RESULTS: The average of absolute correction was, in group 1, 16.5delta and, in group 2, 16.6delta. In group 1, 91.6% of the patients presented satisfactory surgical results and in group 2, 81.8% (p = 0.468. CONCLUSION: The surgical procedure, proposed by Goldstein, is effective and there was no statistical difference between the magnitude of the preoperative anisotropia and the obtained correction.

  9. 单目视觉同步定位与地图创建方法综述%A survey of monocular simultaneous localization and mapping

    Institute of Scientific and Technical Information of China (English)

    顾照鹏; 刘宏

    2015-01-01

    随着计算机视觉技术的发展,基于单目视觉的同步定位与地图创建( monocular SLAM)逐渐成为计算机视觉领域的热点问题之一。介绍了单目视觉SLAM方法的分类,从视觉特征检测与匹配、数据关联的优化、特征点深度的获取、地图的尺度控制几个方面阐述了单目视觉SLAM研究的发展现状。最后,介绍了常见的单目视觉与其他传感器结合的SLAM方法,并探讨了单目视觉SLAM未来的研究方向。%With the development of computer vision technology, monocular simultaneous localization and mapping ( monocular SLAM) has gradually become one of the hot issues in the field of computer vision.This paper intro-duces the monocular vision SLAM classification that relates to the present status of research in monocular SLAM methods from several aspects, including visual feature detection and matching, optimization of data association, depth acquisition of feature points, and map scale control.Monocular SLAM methods combining with other sensors are reviewed and significant issues needing further study are discussed.

  10. Research of the Hash Algorithm Based on MD5%MD5散列算法的研究

    Institute of Scientific and Technical Information of China (English)

    姜学军; 曹烨

    2014-01-01

    借鉴了M.M.J.Stevens的碰撞思路,重新编写了MD5碰撞算法中的核心循环,主要提供一对MD5碰撞产生的过程以及碰撞的完成.通过实验统计分析,利用改进的MD5碰撞算法找到一对碰撞信息所用平均时间不多于60s,且该算法较之传统的MD5碰撞算法具有更好的可读性和可移植性.

  11. Selective REM sleep deprivation in narcolepsy.

    Science.gov (United States)

    Vu, Manh Hoang; Hurni, Christoph; Mathis, Johannes; Roth, Corinne; Bassetti, Claudio L

    2011-03-01

    Narcolepsy is characterized by excessive daytime sleepiness and rapid eye movement (REM) sleep abnormalities, including cataplexy. The aim of this study was to assess REM sleep pressure and homeostasis in narcolepsy. Six patients with narcolepsy and six healthy controls underwent a REM sleep deprivation protocol, including one habituation, one baseline, two deprivation nights (D1, D2) and one recovery night. Multiple sleep latency tests (MSLTs) were performed during the day after baseline and after D2. During D1 and D2 REM sleep was prevented by awakening the subjects at the first polysomnographic signs of REM sleep for 2 min. Mean sleep latency and number of sleep-onset REM periods (SOREMs) were determined on all MSLT. More interventions were required to prevent REM sleep in narcoleptics compared with control subjects during D1 (57 ± 16 versus 24 ± 10) and D2 (87 ± 22 versus 35 ± 8, P = 0.004). Interventions increased from D1 to D2 by 46% in controls and by 53% in narcoleptics (P REM sleep deprivation was successful in both controls (mean reduction of REM to 6% of baseline) and narcoleptics (11%). Both groups had a reduction of total sleep time during the deprivation nights (P = 0.03). Neither group had REM sleep rebound in the recovery night. Narcoleptics had, however, an increase in the number of SOREMs on MSLT (P = 0.005). There was no increase in the number of cataplexies after selective REM sleep deprivation. We conclude that: (i) REM sleep pressure is higher in narcoleptics; (ii) REM sleep homeostasis is similar in narcoleptics and controls; (iii) in narcoleptics selective REM sleep deprivation may have an effect on sleep propensity but not on cataplexy.

  12. Capturing age-related changes in functional contrast sensitivity with decreasing light levels in monocular and binocular vision

    OpenAIRE

    Gillespie-Gallery, H.; Konstantakopoulou, E.; HARLOW, J.A.; Barbur, J. L.

    2013-01-01

    Purpose: It is challenging to separate the effects of normal aging of the retina and visual pathways independently from optical factors, decreased retinal illuminance and early stage disease. This study determined limits to describe the effect of light level on normal, age-related changes in monocular and binocular functional contrast sensitivity. Methods: 95 participants aged 20 to 85 were recruited. Contrast thresholds for correct orientation discrimination of the gap in a Landolt C opt...

  13. Disambiguation of Necker cube rotation by monocular and binocular depth cues: relative effectiveness for establishing long-term bias.

    Science.gov (United States)

    Harrison, Sarah J; Backus, Benjamin T; Jain, Anshul

    2011-05-11

    The apparent direction of rotation of perceptually bistable wire-frame (Necker) cubes can be conditioned to depend on retinal location by interleaving their presentation with cubes that are disambiguated by depth cues (Haijiang, Saunders, Stone, & Backus, 2006; Harrison & Backus, 2010a). The long-term nature of the learned bias is demonstrated by resistance to counter-conditioning on a consecutive day. In previous work, either binocular disparity and occlusion, or a combination of monocular depth cues that included occlusion, internal occlusion, haze, and depth-from-shading, were used to control the rotation direction of disambiguated cubes. Here, we test the relative effectiveness of these two sets of depth cues in establishing the retinal location bias. Both cue sets were highly effective in establishing a perceptual bias on Day 1 as measured by the perceived rotation direction of ambiguous cubes. The effect of counter-conditioning on Day 2, on perceptual outcome for ambiguous cubes, was independent of whether the cue set was the same or different as Day 1. This invariance suggests that a common neural population instantiates the bias for rotation direction, regardless of the cue set used. However, in a further experiment where only disambiguated cubes were presented on Day 1, perceptual outcome of ambiguous cubes during Day 2 counter-conditioning showed that the monocular-only cue set was in fact more effective than disparity-plus-occlusion for causing long-term learning of the bias. These results can be reconciled if the conditioning effect of Day 1 ambiguous trials in the first experiment is taken into account (Harrison & Backus, 2010b). We suggest that monocular disambiguation leads to stronger bias either because it more strongly activates a single neural population that is necessary for perceiving rotation, or because ambiguous stimuli engage cortical areas that are also engaged by monocularly disambiguated stimuli but not by disparity-disambiguated stimuli

  14. 基于MD5和Session的PHP安全防范%PHP security based on Session and MD5

    Institute of Scientific and Technical Information of China (English)

    何秉荣

    2014-01-01

    根据Session工作原理和MD5算法的特性,分析了PHP中Session欺骗与攻击手段,并较有针对性地在防范Session攻击的技术中结合MD5函数,从而提出了一个较为有效、实用的防范措施.

  15. Immediate effects of maternal deprivation on the (reactivity of the HPA axis differ in CD1 and C57Bl/6J mouse pups

    Directory of Open Access Journals (Sweden)

    Nikolaos P Daskalakis

    2014-11-01

    Full Text Available The postnatal development of the mouse is characterised by a period of hypo-responsiveness of the hypothalamic-pituitary-adrenal (HPA axis to mild stressors. Maternal deprivation (MD during this period can disrupt the quiescence of the HPA-axis. The present study examined the influence of strain (outbred CD1 versus inbred C57BL/6J mice on some central and peripheral components of the HPA-axis in neonatal mice (5 day-old in the presence of their mother or after 24 h MD (on postnatal day 4 under basal or mild stressful conditions. In the presence of the dam, adrenal corticosterone (CORT secretion was low in both mouse strains. Compared to CD1 mice, C57BL/6J had lower CORT levels associated with higher ACTH levels and ACTH/CORT ratio (i.e., lower adrenal sensitivity to ACTH, and higher glucocorticoid receptor (GR mRNA expression in the paraventricular nucleus. Although MD disinhibited the HPA-axis in both strains as reflected by increased basal CORT and ACTH, we found a strain-dependent pattern. MD increased CORT more in C57BL/6J, compared to CD1 mice, together with a lower ACTH/CORT ratio (i.e., higher adrenal sensitivity to ACTH, while GR mRNA was no longer different in the two strains. However, this increased adrenal sensitivity in maternally deprived C57BL/6J mice was not reflected in their CORT response to a subsequent novelty stressor, possibly due to a MD-induced ceiling effect in their steroidogenic capacity.In conclusion, the immediate outcome of MD depends on the genetic background of the mother-infant dyad, suggesting that maybe also the outcome in later-life cannot be generalized. genetic background of the mother-infant dyad, predicting that the outcome in later-life cannot be generalized.

  16. Malnutrition and the family: deprivation in kwashiorkor.

    Science.gov (United States)

    Goodall, J

    1979-05-01

    The background to social and emotional deprivation is discussed and applied to a study of kwashiorkor in East African children. A group of 107 children with kwashiorkor was compared with 111 controls. Age, sex and tribe were all found to have significances of their own: fifty of each group were therefore matched for these three factors. Ten other factors were found to be significant in the background of children with kwashiorkor, all of which could be associated with social or emotional deprivation or both (see Table 14). It is concluded that, in childhood, sustained personal care and affection are essential to normal growth.

  17. Deprivation of Dignity in Nursing Home Residents

    DEFF Research Database (Denmark)

    Høy, Bente

    2012-01-01

    deepened knowledge in how to maintain and promote dignity in nursing home residents. The purpose of this paper is to present results concerning the question: How is nursing home residents’ dignity maintained or deprived from the perspective of close family caregivers? In this presentation we only focus...... on deprivation of dignity. Methodology: The overall design of this study is modified clinical application research. The study took place at six different nursing home residences in Sweden, Denmark and Norway. Data collection methods were individual research interviews. All together the sample consisted of 28...

  18. Sleep Deprivation: A Cause of High Blood Pressure?

    Science.gov (United States)

    ... High blood pressure (hypertension) Is it true that sleep deprivation can cause high blood pressure? Answers from Sheldon ... Cirelli C, et al. Definition and consequences of sleep deprivation. http://www.uptodate.com/home. Accessed March 24, ...

  19. Perception of scene-relative object movement: Optic flow parsing and the contribution of monocular depth cues.

    Science.gov (United States)

    Warren, Paul A; Rushton, Simon K

    2009-05-01

    We have recently suggested that the brain uses its sensitivity to optic flow in order to parse retinal motion into components arising due to self and object movement (e.g. Rushton, S. K., & Warren, P. A. (2005). Moving observers, 3D relative motion and the detection of object movement. Current Biology, 15, R542-R543). Here, we explore whether stereo disparity is necessary for flow parsing or whether other sources of depth information, which could theoretically constrain flow-field interpretation, are sufficient. Stationary observers viewed large field of view stimuli containing textured cubes, moving in a manner that was consistent with a complex observer movement through a stationary scene. Observers made speeded responses to report the perceived direction of movement of a probe object presented at different depths in the scene. Across conditions we varied the presence or absence of different binocular and monocular cues to depth order. In line with previous studies, results consistent with flow parsing (in terms of both perceived direction and response time) were found in the condition in which motion parallax and stereoscopic disparity were present. Observers were poorer at judging object movement when depth order was specified by parallax alone. However, as more monocular depth cues were added to the stimulus the results approached those found when the scene contained stereoscopic cues. We conclude that both monocular and binocular static depth information contribute to flow parsing. These findings are discussed in the context of potential architectures for a model of the flow parsing mechanism.

  20. Measuring young infants' sensitivity to height-in-the-picture-plane by contrasting monocular and binocular preferential-looking.

    Science.gov (United States)

    Tsuruhara, Aki; Corrow, Sherryse; Kanazawa, So; Yamaguchi, Masami K; Yonas, Albert

    2014-01-01

    To examine young infants' sensitivity to a pictorial depth cue, we compared monocular and binocular preferential looking to objects of which depth was specified by height-in-the-picture-plane. For adults, this cue generates the perception that a lower object is closer than a higher object. This study showed that 4- and 5-month-old infants fixated the lower, apparently closer, figure more often under the monocular than binocular presentation providing evidence of their sensitivity to the pictorial depth cue. Because the displays were identical in the two conditions except for binocular information for depth, the difference in looking-behavior indicated sensitivity to depth information, excluding a possibility that they responded to 2D characteristics. This study also confirmed the usefulness of the method, preferential looking with a monocular and binocular comparison, to examine sensitivity to a pictorial depth cue in young infants, who are too immature to reach reliably for the closer of two objects. © 2013 Wiley Periodicals, Inc.

  1. Gene Networks Underlying Chronic Sleep Deprivation in Drosophila

    Science.gov (United States)

    2014-06-15

    SECURITY CLASSIFICATION OF: Studies of the gene network affected by sleep deprivation and stress in the fruit fly Drosophila have revealed the...15-Apr-2009 14-Apr-2013 Approved for Public Release; Distribution Unlimited Gene Networks Underlying Chronic Sleep Deprivation in Drosophila The...Chronic Sleep Deprivation in Drosophila Report Title Studies of the gene network affected by sleep deprivation and stress in the fruit fly Drosophila have

  2. Quality of life in patients with age-related macular degeneration with monocular and binocular legal blindness Qualidade de vida de pacientes com degeneração macular relacionada à idade com cegueira legal monocular e binocular

    Directory of Open Access Journals (Sweden)

    Roberta Ferrari Marback

    2007-01-01

    Full Text Available OBJECTIVE: To evaluate the quality of life for persons affected by age-related macular degeneration that results in monocular or binocular legal blindness. METHODS: An analytic transversal study using the National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25 was performed. Inclusion criteria were persons of both genders, aged more than 50 years old, absence of cataracts, diagnosis of age-related monocular degeneration in at least one eye and the absence of other macular diseases. The control group was paired by sex, age and no ocular disease. RESULTS: Group 1 (monocular legal blindness was composed of 54 patients (72.22% females and 27.78% males, aged 51 to 87 years old, medium age 74.61 ± 7.27 years; group 2 (binocular legal blindness was composed of 54 patients (46.30% females and 53.70% males aged 54 to 87 years old, medium age 75.61 ± 6.34 years. The control group was composed of 40 patients (40% females and 60% males, aged 50 to 81 years old, medium age 65.65 ± 7.56 years. The majority of the scores were statistically significantly higher in group 1 and the control group in relation to group 2 and higher in the control group when compared to group 1. CONCLUSIONS: It was evident that the quality of life of persons with binocular blindness was more limited in relation to persons with monocular blindness. Both groups showed significant impairment in quality of life when compared to normal persons.OBJETIVO: Avaliar a qualidade de vida de portadores de degeneração macular relacionada à idade com cegueira legal monocular e binocular. MÉTODOS: Foi realizado estudo transversal analítico por meio do questionário National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25. Os critérios de inclusão foram: indivíduos de ambos os sexos, idade maior que 50 anos, ausência de catarata, diagnóstico de degeneração macular relacionada à idade avançada em pelo menos um dos olhos, sem outras maculopatias. O Grupo Controle

  3. Occlusion for stimulus deprivation amblyopia

    Science.gov (United States)

    Antonio-Santos, Aileen; Vedula, Satyanarayana S; Hatt, Sarah R; Powell, Christine

    2014-01-01

    Background Stimulus deprivation amblyopia (SDA) develops due to an obstruction to the passage of light secondary to a condition such as cataract. The obstruction prevents formation of a clear image on the retina. SDA can be resistant to treatment, leading to poor visual prognosis. SDA probably constitutes less than 3% of all amblyopia cases, although precise estimates of prevalence are unknown. In developed countries, most patients present under the age of one year; in less developed parts of the world patients are likely to be older at the time of presentation. The mainstay of treatment is removal of the cataract and then occlusion of the better-seeing eye, but regimens vary, can be difficult to execute, and traditionally are believed to lead to disappointing results. Objectives Our objective was to evaluate the effectiveness of occlusion therapy for SDA in an attempt to establish realistic treatment outcomes. Where data were available, we also planned to examine evidence of any dose response effect and to assess the effect of the duration, severity, and causative factor on the size and direction of the treatment effect. Search methods We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2013, Issue 9), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to October 2013), EMBASE (January 1980 to October 2013), the Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to October 2013), PubMed (January 1946 to October 2013), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 28 October 2013. Selection criteria We planned

  4. Sleep deprivation impairs cAMP signalling in the hippocampus

    NARCIS (Netherlands)

    Vecsey, Christopher G; Baillie, George S; Jaganath, Devan; Havekes, Robbert; Daniels, Andrew; Wimmer, Mathieu; Huang, Ted; Brown, Kim M; Li, Xiang-Yao; Descalzi, Giannina; Kim, Susan S; Chen, Tao; Shang, Yu-Ze; Zhuo, Min; Houslay, Miles D; Abel, Ted

    2009-01-01

    Millions of people regularly obtain insufficient sleep. Given the effect of sleep deprivation on our lives, understanding the cellular and molecular pathways affected by sleep deprivation is clearly of social and clinical importance. One of the major effects of sleep deprivation on the brain is to p

  5. Sleep deprivation impairs cAMP signalling in the hippocampus

    NARCIS (Netherlands)

    Vecsey, Christopher G; Baillie, George S; Jaganath, Devan; Havekes, Robbert; Daniels, Andrew; Wimmer, Mathieu; Huang, Ted; Brown, Kim M; Li, Xiang-Yao; Descalzi, Giannina; Kim, Susan S; Chen, Tao; Shang, Yu-Ze; Zhuo, Min; Houslay, Miles D; Abel, Ted

    2009-01-01

    Millions of people regularly obtain insufficient sleep. Given the effect of sleep deprivation on our lives, understanding the cellular and molecular pathways affected by sleep deprivation is clearly of social and clinical importance. One of the major effects of sleep deprivation on the brain is to

  6. Sleep deprivation impairs cAMP signalling in the hippocampus

    NARCIS (Netherlands)

    Vecsey, Christopher G; Baillie, George S; Jaganath, Devan; Havekes, Robbert; Daniels, Andrew; Wimmer, Mathieu; Huang, Ted; Brown, Kim M; Li, Xiang-Yao; Descalzi, Giannina; Kim, Susan S; Chen, Tao; Shang, Yu-Ze; Zhuo, Min; Houslay, Miles D; Abel, Ted

    2009-01-01

    Millions of people regularly obtain insufficient sleep. Given the effect of sleep deprivation on our lives, understanding the cellular and molecular pathways affected by sleep deprivation is clearly of social and clinical importance. One of the major effects of sleep deprivation on the brain is to p

  7. Long term sex-dependent psychoneuroendocrine effects of maternal deprivation and juvenile unpredictable stress in rats.

    Science.gov (United States)

    Llorente, R; Miguel-Blanco, C; Aisa, B; Lachize, S; Borcel, E; Meijer, O C; Ramirez, M J; De Kloet, E R; Viveros, M P

    2011-04-01

    We have analysed the long-term psychoneuroendocrine effects of maternal deprivation (MD) [24 h at postnatal day (PND) 9] and/or exposure to chronic unpredictable stress (CUS) during the periadolescent period (PND 28 to PND 43) in male and female Wistar rats. Animals were tested in the elevated plus maze (EPM, anxiety) at PND 44 and in two memory tests, spontaneous alternation and novel object recognition (NOT) in adulthood. The expression of hippocampal glucocorticoid (GR) and mineralocorticoid (MR) receptors, as well as of synaptophysin, neural cell adhesion molecule and brain-derived neurotrophic factor, was analysed by in situ hybridisation in selected hippocampal regions. Endocrine determinations of leptin, testosterone and oestradiol plasma levels were carried out by radioimmunoassay. Young CUS animals showed decreased anxiety behaviour in the EPM (increased percentage of time and entries in the open arms) irrespective of neonatal treatment. Memory impairments were induced by the two stressful treatments as was revealed by the NOT, with males being most clearly affected. Although each stressful procedure, when considered separately, induced different (always decrements) effects on the three synaptic molecules analysed and affected males and females differently, the combination of MD and CUS induced an unique disruptive effect on the three synaptic plasticity players. MD induced a long-term significant decrease in hippocampal GR only in males, whereas CUS tended to increase MR in males and decrease MR in females. Both neonatal MD and periadolescent CUS induced marked reductions in testosterone and oestradiol in males, whereas MD male animals also showed significantly decreased leptin levels. By contrast, in females, none of the hormones analysed was altered by any of the stressful procedures. Taking our data together in support of the 'two-hit' hypothesis, MD during neonatal life and/or exposure to CUS during the periadolescent period induced a permanent

  8. Monocular and binocular steady-state flicker VEPs: frequency-response functions to sinusoidal and square-wave luminance modulation.

    Science.gov (United States)

    Nicol, David S; Hamilton, Ruth; Shahani, Uma; McCulloch, Daphne L

    2011-02-01

    Steady-state VEPs to full-field flicker (FFF) using sinusoidally modulated light were compared with those elicited by square-wave modulated light across a wide range of stimulus frequencies with monocular and binocular FFF stimulation. Binocular and monocular VEPs were elicited in 12 adult volunteers to FFF with two modes of temporal modulation: sinusoidal or square-wave (abrupt onset and offset, 50% duty cycle) at ten temporal frequencies ranging from 2.83 to 58.8 Hz. All stimuli had a mean luminance of 100 cd/m(2) with an 80% modulation depth (20-180 cd/m(2)). Response magnitudes at the stimulus frequency (F1) and at the double and triple harmonics (F2 and F3) were compared. For both sinusoidal and square-wave flicker, the FFF-VEP magnitudes at F1 were maximal for 7.52 Hz flicker. F2 was maximal for 5.29 Hz flicker, and F3 magnitudes are largest for flicker stimulation from 3.75 to 7.52 Hz. Square-wave flicker produced significantly larger F1 and F2 magnitudes for slow flicker rates (up to 5.29 Hz for F1; at 2.83 and 3.75 Hz for F2). The F3 magnitudes were larger overall for square-wave flicker. Binocular FFF-VEP magnitudes are larger than those of monocular FFF-VEPs, and the amount of this binocular enhancement is not dependant on the mode of flicker stimulation (mean binocular: monocular ratio 1.41, 95% CI: 1.2-1.6). Binocular enhancement of F1 for 21.3 Hz flicker was increased to a factor of 2.5 (95% CI: 1.8-3.5). In the healthy adult visual system, FFF-VEP magnitudes can be characterized by the frequency-response functions of F1, F2 and F3. Low-frequency roll-off in the FFF-VEP magnitudes is greater for sinusoidal flicker than for square-wave flicker for rates ≤ 5.29 Hz; magnitudes for higher-frequency flicker are similar for the two types of flicker. Binocular FFF-VEPs are larger overall than those recorded monocularly, and this binocular summation is enhanced at 21.3 Hz in the mid-frequency range.

  9. Health-risk behaviour in deprived neighbourhoods compared with non-deprived neighbourhoods

    DEFF Research Database (Denmark)

    Algren, Maria Holst; Bak, Carsten Kronborg; Berg-Beckhoff, Gabriele;

    2015-01-01

    BACKGROUND: There has been increasing interest in neighbourhoods' influence on individuals' health-risk behaviours, such as smoking, alcohol consumption, physical activity and diet. The aim of this review was to systematically review recent studies on health-risk behaviour among adults who live......Med, Embase, Web of Science and Sociological Abstracts using relevant search terms, Boolean operators, and truncation, and reference lists were scanned. Quantitative observational studies that examined health-risk behaviour in deprived neighbourhoods compared with non-deprived neighbourhoods were eligible...... for inclusion. RESULTS: The inclusion criteria were met by 22 studies. The available literature showed a positive association between smoking and physical inactivity and living in deprived neighbourhoods compared with non-deprived neighbourhoods. In regard to low fruit and vegetable consumption and alcohol...

  10. Relative Deprivation and the Gender Wage Gap.

    Science.gov (United States)

    Jackson, Linda A.

    1989-01-01

    Discusses how gender differences in the value of pay, based on relative deprivation theory, explain women's paradoxical contentment with lower wages. Presents a model of pay satisfaction to integrate value-based and comparative-referent explanations of the relationship between gender and pay satisfaction. Discusses economic approaches to the…

  11. Sleep deprivation impairs object recognition in mice

    NARCIS (Netherlands)

    Palchykova, S; Winsky-Sommerer, R; Meerlo, P; Durr, R; Tobler, Irene

    2006-01-01

    Many studies in animals and humans suggest that sleep facilitates learning, memory consolidation, and retrieval. Moreover, sleep deprivation (SD) incurred after learning, impaired memory in humans, mice, rats, and hamsters. We investigated the importance of sleep and its timing in in object

  12. Binocular form deprivation influences the visual cortex

    Institute of Scientific and Technical Information of China (English)

    Mingming Liu; Chuanhuang Weng; Hanping Xie; Wei Qin

    2012-01-01

    1a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors are considered to play a crucial role in synaptic plasticity in the developing visual cortex. In this study, we established a rat model of binocular form deprivation by suturing the rat binocular eyelids before eye-opening at postnatal day 14. During development, the decay time of excitatory postsynaptic currents mediated by 1a-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptors of normal rats became longer after eyeopening; however, the decay time did not change significantly in binocular form deprivation rats. The peak value in the normal group became gradually larger with age, but there was no significant change in the binocular form deprivation group. These findings indicate that binocular form deprivation influences the properties of excitatory postsynaptic currents mediated by β-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat visual cortex around the end of the critical period, indicating that form stimulation is associated with the experience-dependent modification of neuronal synapses in the visual cortex.

  13. Infant Face Preferences after Binocular Visual Deprivation

    Science.gov (United States)

    Mondloch, Catherine J.; Lewis, Terri L.; Levin, Alex V.; Maurer, Daphne

    2013-01-01

    Early visual deprivation impairs some, but not all, aspects of face perception. We investigated the possible developmental roots of later abnormalities by using a face detection task to test infants treated for bilateral congenital cataract within 1 hour of their first focused visual input. The seven patients were between 5 and 12 weeks old…

  14. Relative Deprivation and the Gender Wage Gap.

    Science.gov (United States)

    Jackson, Linda A.

    1989-01-01

    Discusses how gender differences in the value of pay, based on relative deprivation theory, explain women's paradoxical contentment with lower wages. Presents a model of pay satisfaction to integrate value-based and comparative-referent explanations of the relationship between gender and pay satisfaction. Discusses economic approaches to the…

  15. Relative Deprivation, Rising Expectations, and Black Militancy

    Science.gov (United States)

    Abeles, Ronald P.

    1976-01-01

    Investigates the role of relative deprivation (RD) and rising expectations (RE) as mediating variables between social structure and black militancy through secondary analyses of survey data of blacks living in Cleveland and Miami in the late 1960s. Alternative explanations and implications derived from the present data and the theories for the…

  16. Deprivation as un-experienced harm?

    DEFF Research Database (Denmark)

    Keerus, Külli; Gjerris, Mickey; Röcklinsberg, Helena

    2017-01-01

    Tom Regan encapsulated his principle of harm as a prima facie direct duty not to harm experiencing subjects of a life. However, his consideration of harm as deprivation, one example of which is loss of freedom, can easily be interpreted as a harm, which may not be experienced by its subject...

  17. Cummins MD & HD Accessory Hybridization CRADA -Annual Report FY15

    Energy Technology Data Exchange (ETDEWEB)

    Deter, Dean D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    There are many areas of MD and HD vehicles that can be improved by new technologies and optimized control strategies. Component optimization and idle reduction need to be addressed, this is best done by a two part approach that includes selecting the best component technology, and/or architecture, and optimized controls that are vehicle focused. While this is a common focus in the light duty industry it has been gaining momentum in the MD and HD market as the market gets more competitive and the regulations become more stringent. When looking into systems optimization and idle reduction technologies, affected vehicle systems must first be considered, and if possible included in the new architecture to get the most benefit out of these new capabilities. Typically, when looking into idle reduction or component optimization for MD/HD, the vehicle s accessories become a prime candidate for electrification or hybridization. While this has already been studied on light duty vehicles (especially on hybrids and electric vehicles) it has not made any head way or market penetration in most MD and HD applications. If hybrids and electric MD and HD vehicles begin to break into the market this would be a necessary step into the ability to make those vehicles successful by allowing for independent, optimized operation separate from the engine.

  18. Monocular Vision System for Fixed Altitude Flight of Unmanned Aerial Vehicles.

    Science.gov (United States)

    Huang, Kuo-Lung; Chiu, Chung-Cheng; Chiu, Sheng-Yi; Teng, Yao-Jen; Hao, Shu-Sheng

    2015-07-13

    The fastest and most economical method of acquiring terrain images is aerial photography. The use of unmanned aerial vehicles (UAVs) has been investigated for this task. However, UAVs present a range of challenges such as flight altitude maintenance. This paper reports a method that combines skyline detection with a stereo vision algorithm to enable the flight altitude of UAVs to be maintained. A monocular camera is mounted on the downside of the aircraft's nose to collect continuous ground images, and the relative altitude is obtained via a stereo vision algorithm from the velocity of the UAV. Image detection is used to obtain terrain images, and to measure the relative altitude from the ground to the UAV. The UAV flight system can be set to fly at a fixed and relatively low altitude to obtain the same resolution of ground images. A forward-looking camera is mounted on the upside of the aircraft's nose. In combination with the skyline detection algorithm, this helps the aircraft to maintain a stable flight pattern. Experimental results show that the proposed system enables UAVs to obtain terrain images at constant resolution, and to detect the relative altitude along the flight path.

  19. Automatic Human Facial Expression Recognition Based on Integrated Classifier From Monocular Video with Uncalibrated Camera

    Directory of Open Access Journals (Sweden)

    Yu Tao

    2017-01-01

    Full Text Available An automatic recognition framework for human facial expressions from a monocular video with an uncalibrated camera is proposed. The expression characteristics are first acquired from a kind of deformable template, similar to a facial muscle distribution. After associated regularization, the time sequences from the trait changes in space-time under complete expressional production are then arranged line by line in a matrix. Next, the matrix dimensionality is reduced by a method of manifold learning of neighborhood-preserving embedding. Finally, the refined matrix containing the expression trait information is recognized by a classifier that integrates the hidden conditional random field (HCRF and support vector machine (SVM. In an experiment using the Cohn–Kanade database, the proposed method showed a comparatively higher recognition rate than the individual HCRF or SVM methods in direct recognition from two-dimensional human face traits. Moreover, the proposed method was shown to be more robust than the typical Kotsia method because the former contains more structural characteristics of the data to be classified in space-time

  20. Stereoscopic 3D-scene synthesis from a monocular camera with an electrically tunable lens

    Science.gov (United States)

    Alonso, Julia R.

    2016-09-01

    3D-scene acquisition and representation is important in many areas ranging from medical imaging to visual entertainment application. In this regard, optical imaging acquisition combined with post-capture processing algorithms enable the synthesis of images with novel viewpoints of a scene. This work presents a new method to reconstruct a pair of stereoscopic images of a 3D-scene from a multi-focus image stack. A conventional monocular camera combined with an electrically tunable lens (ETL) is used for image acquisition. The captured visual information is reorganized considering a piecewise-planar image formation model with a depth-variant point spread function (PSF) along with the known focusing distances at which the images of the stack were acquired. The consideration of a depth-variant PSF allows the application of the method to strongly defocused multi-focus image stacks. Finally, post-capture perspective shifts, presenting each eye the corresponding viewpoint according to the disparity, are generated by simulating the displacement of a synthetic pinhole camera. The procedure is performed without estimation of the depth-map or segmentation of the in-focus regions. Experimental results for both real and synthetic data images are provided and presented as anaglyphs, but it could easily be implemented in 3D displays based in parallax barrier or polarized light.

  1. A Monocular Vision Sensor-Based Obstacle Detection Algorithm for Autonomous Robots

    Science.gov (United States)

    Lee, Tae-Jae; Yi, Dong-Hoon; Cho, Dong-Il “Dan”

    2016-01-01

    This paper presents a monocular vision sensor-based obstacle detection algorithm for autonomous robots. Each individual image pixel at the bottom region of interest is labeled as belonging either to an obstacle or the floor. While conventional methods depend on point tracking for geometric cues for obstacle detection, the proposed algorithm uses the inverse perspective mapping (IPM) method. This method is much more advantageous when the camera is not high off the floor, which makes point tracking near the floor difficult. Markov random field-based obstacle segmentation is then performed using the IPM results and a floor appearance model. Next, the shortest distance between the robot and the obstacle is calculated. The algorithm is tested by applying it to 70 datasets, 20 of which include nonobstacle images where considerable changes in floor appearance occur. The obstacle segmentation accuracies and the distance estimation error are quantitatively analyzed. For obstacle datasets, the segmentation precision and the average distance estimation error of the proposed method are 81.4% and 1.6 cm, respectively, whereas those for a conventional method are 57.5% and 9.9 cm, respectively. For nonobstacle datasets, the proposed method gives 0.0% false positive rates, while the conventional method gives 17.6%. PMID:26938540

  2. Monocular Vision System for Fixed Altitude Flight of Unmanned Aerial Vehicles

    Directory of Open Access Journals (Sweden)

    Kuo-Lung Huang

    2015-07-01

    Full Text Available The fastest and most economical method of acquiring terrain images is aerial photography. The use of unmanned aerial vehicles (UAVs has been investigated for this task. However, UAVs present a range of challenges such as flight altitude maintenance. This paper reports a method that combines skyline detection with a stereo vision algorithm to enable the flight altitude of UAVs to be maintained. A monocular camera is mounted on the downside of the aircraft’s nose to collect continuous ground images, and the relative altitude is obtained via a stereo vision algorithm from the velocity of the UAV. Image detection is used to obtain terrain images, and to measure the relative altitude from the ground to the UAV. The UAV flight system can be set to fly at a fixed and relatively low altitude to obtain the same resolution of ground images. A forward-looking camera is mounted on the upside of the aircraft’s nose. In combination with the skyline detection algorithm, this helps the aircraft to maintain a stable flight pattern. Experimental results show that the proposed system enables UAVs to obtain terrain images at constant resolution, and to detect the relative altitude along the flight path.

  3. A Height Estimation Approach for Terrain Following Flights from Monocular Vision

    Directory of Open Access Journals (Sweden)

    Igor S. G. Campos

    2016-12-01

    Full Text Available In this paper, we present a monocular vision-based height estimation algorithm for terrain following flights. The impressive growth of Unmanned Aerial Vehicle (UAV usage, notably in mapping applications, will soon require the creation of new technologies to enable these systems to better perceive their surroundings. Specifically, we chose to tackle the terrain following problem, as it is still unresolved for consumer available systems. Virtually every mapping aircraft carries a camera; therefore, we chose to exploit this in order to use presently available hardware to extract the height information toward performing terrain following flights. The proposed methodology consists of using optical flow to track features from videos obtained by the UAV, as well as its motion information to estimate the flying height. To determine if the height estimation is reliable, we trained a decision tree that takes the optical flow information as input and classifies whether the output is trustworthy or not. The classifier achieved accuracies of 80 % for positives and 90 % for negatives, while the height estimation algorithm presented good accuracy.

  4. A Height Estimation Approach for Terrain Following Flights from Monocular Vision.

    Science.gov (United States)

    Campos, Igor S G; Nascimento, Erickson R; Freitas, Gustavo M; Chaimowicz, Luiz

    2016-12-06

    In this paper, we present a monocular vision-based height estimation algorithm for terrain following flights. The impressive growth of Unmanned Aerial Vehicle (UAV) usage, notably in mapping applications, will soon require the creation of new technologies to enable these systems to better perceive their surroundings. Specifically, we chose to tackle the terrain following problem, as it is still unresolved for consumer available systems. Virtually every mapping aircraft carries a camera; therefore, we chose to exploit this in order to use presently available hardware to extract the height information toward performing terrain following flights. The proposed methodology consists of using optical flow to track features from videos obtained by the UAV, as well as its motion information to estimate the flying height. To determine if the height estimation is reliable, we trained a decision tree that takes the optical flow information as input and classifies whether the output is trustworthy or not. The classifier achieved accuracies of 80 % for positives and 90 % for negatives, while the height estimation algorithm presented good accuracy.

  5. RBF-Based Monocular Vision Navigation for Small Vehicles in Narrow Space below Maize Canopy

    Directory of Open Access Journals (Sweden)

    Lu Liu

    2016-06-01

    Full Text Available Maize is one of the major food crops in China. Traditionally, field operations are done by manual labor, where the farmers are threatened by the harsh environment and pesticides. On the other hand, it is difficult for large machinery to maneuver in the field due to limited space, particularly in the middle and late growth stage of maize. Unmanned, compact agricultural machines, therefore, are ideal for such field work. This paper describes a method of monocular visual recognition to navigate small vehicles between narrow crop rows. Edge detection and noise elimination were used for image segmentation to extract the stalks in the image. The stalk coordinates define passable boundaries, and a simplified radial basis function (RBF-based algorithm was adapted for path planning to improve the fault tolerance of stalk coordinate extraction. The average image processing time, including network latency, is 220 ms. The average time consumption for path planning is 30 ms. The fast processing ensures a top speed of 2 m/s for our prototype vehicle. When operating at the normal speed (0.7 m/s, the rate of collision with stalks is under 6.4%. Additional simulations and field tests further proved the feasibility and fault tolerance of our method.

  6. Maximum Likelihood Estimation of Monocular Optical Flow Field for Mobile Robot Ego-motion

    Directory of Open Access Journals (Sweden)

    Huajun Liu

    2016-01-01

    Full Text Available This paper presents an optimized scheme of monocular ego-motion estimation to provide location and pose information for mobile robots with one fixed camera. First, a multi-scale hyper-complex wavelet phase-derived optical flow is applied to estimate micro motion of image blocks. Optical flow computation overcomes the difficulties of unreliable feature selection and feature matching of outdoor scenes; at the same time, the multi-scale strategy overcomes the problem of road surface self-similarity and local occlusions. Secondly, a support probability of flow vector is defined to evaluate the validity of the candidate image motions, and a Maximum Likelihood Estimation (MLE optical flow model is constructed based not only on image motion residuals but also their distribution of inliers and outliers, together with their support probabilities, to evaluate a given transform. This yields an optimized estimation of inlier parts of optical flow. Thirdly, a sampling and consensus strategy is designed to estimate the ego-motion parameters. Our model and algorithms are tested on real datasets collected from an intelligent vehicle. The experimental results demonstrate the estimated ego-motion parameters closely follow the GPS/INS ground truth in complex outdoor road scenarios.

  7. Acute Myeloid Leukemia Relapse Presenting as Complete Monocular Vision Loss due to Optic Nerve Involvement

    Directory of Open Access Journals (Sweden)

    Shyam A. Patel

    2016-01-01

    Full Text Available Acute myeloid leukemia (AML involvement of the central nervous system is relatively rare, and detection of leptomeningeal disease typically occurs only after a patient presents with neurological symptoms. The case herein describes a 48-year-old man with relapsed/refractory AML of the mixed lineage leukemia rearrangement subtype, who presents with monocular vision loss due to leukemic eye infiltration. MRI revealed right optic nerve sheath enhancement and restricted diffusion concerning for nerve ischemia and infarct from hypercellularity. Cerebrospinal fluid (CSF analysis showed a total WBC count of 81/mcl with 96% AML blasts. The onset and progression of visual loss were in concordance with rise in peripheral blood blast count. A low threshold for diagnosis of CSF involvement should be maintained in patients with hyperleukocytosis and high-risk cytogenetics so that prompt treatment with whole brain radiation and intrathecal chemotherapy can be delivered. This case suggests that the eye, as an immunoprivileged site, may serve as a sanctuary from which leukemic cells can resurge and contribute to relapsed disease in patients with high-risk cytogenetics.

  8. Cross-Covariance Estimation for Ekf-Based Inertial Aided Monocular Slam

    Science.gov (United States)

    Kleinert, M.; Stilla, U.

    2011-04-01

    Repeated observation of several characteristically textured surface elements allows the reconstruction of the camera trajectory and a sparse point cloud which is often referred to as "map". The extended Kalman filter (EKF) is a popular method to address this problem, especially if real-time constraints have to be met. Inertial measurements as well as a parameterization of the state vector that conforms better to the linearity assumptions made by the EKF may be employed to reduce the impact of linearization errors. Therefore, we adopt an inertial-aided monocular SLAM approach where landmarks are parameterized in inverse depth w.r.t. the coordinate system in which they were observed for the first time. In this work we present a method to estimate the cross-covariances between landmarks which are introduced in the EKF state vector for the first time and the old filter state that can be applied in the special case at hand where each landmark is parameterized w.r.t. an individual coordinate system.

  9. 3D Reconstruction from a Single Still Image Based on Monocular Vision of an Uncalibrated Camera

    Directory of Open Access Journals (Sweden)

    Yu Tao

    2017-01-01

    Full Text Available we propose a framework of combining Machine Learning with Dynamic Optimization for reconstructing scene in 3D automatically from a single still image of unstructured outdoor environment based on monocular vision of an uncalibrated camera. After segmenting image first time, a kind of searching tree strategy based on Bayes rule is used to identify the hierarchy of all areas on occlusion. After superpixel segmenting image second time, the AdaBoost algorithm is applied in the integration detection to the depth of lighting, texture and material. Finally, all the factors above are optimized with constrained conditions, acquiring the whole depthmap of an image. Integrate the source image with its depthmap in point-cloud or bilinear interpolation styles, realizing 3D reconstruction. Experiment in comparisons with typical methods in associated database demonstrates our method improves the reasonability of estimation to the overall 3D architecture of image’s scene to a certain extent. And it does not need any manual assist and any camera model information.

  10. Exploiting Depth From Single Monocular Images for Object Detection and Semantic Segmentation

    Science.gov (United States)

    Cao, Yuanzhouhan; Shen, Chunhua; Shen, Heng Tao

    2017-02-01

    Augmenting RGB data with measured depth has been shown to improve the performance of a range of tasks in computer vision including object detection and semantic segmentation. Although depth sensors such as the Microsoft Kinect have facilitated easy acquisition of such depth information, the vast majority of images used in vision tasks do not contain depth information. In this paper, we show that augmenting RGB images with estimated depth can also improve the accuracy of both object detection and semantic segmentation. Specifically, we first exploit the recent success of depth estimation from monocular images and learn a deep depth estimation model. Then we learn deep depth features from the estimated depth and combine with RGB features for object detection and semantic segmentation. Additionally, we propose an RGB-D semantic segmentation method which applies a multi-task training scheme: semantic label prediction and depth value regression. We test our methods on several datasets and demonstrate that incorporating information from estimated depth improves the performance of object detection and semantic segmentation remarkably.

  11. Why is binocular rivalry uncommon? Discrepant monocular images in the real world

    Directory of Open Access Journals (Sweden)

    Derek Henry Arnold

    2011-10-01

    Full Text Available When different images project to corresponding points in the two eyes they can instigate a phenomenon called binocular rivalry (BR, wherein each image seems to intermittently disappear such that only one of the two images is seen at a time. Cautious readers may have noted an important caveat in the opening sentence – this situation can instigate BR, but usually it doesn’t. Unmatched monocular images are frequently encountered in daily life due to either differential occlusions of the two eyes or because of selective obstructions of just one eye, but this does not tend to induce BR. Here I will explore the reasons for this and discuss implications for BR in general. It will be argued that BR is resolved in favour of the instantaneously stronger neural signal, and that this process is driven by an adaptation that enhances the visibility of distant fixated objects over that of more proximate obstructions of an eye. Accordingly, BR would reflect the dynamics of an inherently visual operation that usually deals with real-world constraints.

  12. A Height Estimation Approach for Terrain Following Flights from Monocular Vision

    Science.gov (United States)

    Campos, Igor S. G.; Nascimento, Erickson R.; Freitas, Gustavo M.; Chaimowicz, Luiz

    2016-01-01

    In this paper, we present a monocular vision-based height estimation algorithm for terrain following flights. The impressive growth of Unmanned Aerial Vehicle (UAV) usage, notably in mapping applications, will soon require the creation of new technologies to enable these systems to better perceive their surroundings. Specifically, we chose to tackle the terrain following problem, as it is still unresolved for consumer available systems. Virtually every mapping aircraft carries a camera; therefore, we chose to exploit this in order to use presently available hardware to extract the height information toward performing terrain following flights. The proposed methodology consists of using optical flow to track features from videos obtained by the UAV, as well as its motion information to estimate the flying height. To determine if the height estimation is reliable, we trained a decision tree that takes the optical flow information as input and classifies whether the output is trustworthy or not. The classifier achieved accuracies of 80% for positives and 90% for negatives, while the height estimation algorithm presented good accuracy. PMID:27929424

  13. A Monocular Vision Sensor-Based Obstacle Detection Algorithm for Autonomous Robots

    Directory of Open Access Journals (Sweden)

    Tae-Jae Lee

    2016-03-01

    Full Text Available This paper presents a monocular vision sensor-based obstacle detection algorithm for autonomous robots. Each individual image pixel at the bottom region of interest is labeled as belonging either to an obstacle or the floor. While conventional methods depend on point tracking for geometric cues for obstacle detection, the proposed algorithm uses the inverse perspective mapping (IPM method. This method is much more advantageous when the camera is not high off the floor, which makes point tracking near the floor difficult. Markov random field-based obstacle segmentation is then performed using the IPM results and a floor appearance model. Next, the shortest distance between the robot and the obstacle is calculated. The algorithm is tested by applying it to 70 datasets, 20 of which include nonobstacle images where considerable changes in floor appearance occur. The obstacle segmentation accuracies and the distance estimation error are quantitatively analyzed. For obstacle datasets, the segmentation precision and the average distance estimation error of the proposed method are 81.4% and 1.6 cm, respectively, whereas those for a conventional method are 57.5% and 9.9 cm, respectively. For nonobstacle datasets, the proposed method gives 0.0% false positive rates, while the conventional method gives 17.6%.

  14. Development of an indoor positioning and navigation system using monocular SLAM and IMU

    Science.gov (United States)

    Mai, Yu-Ching; Lai, Ying-Chih

    2016-07-01

    The positioning and navigation systems based on Global Positioning System (GPS) have been developed over past decades and have been widely used for outdoor environment. However, high-rise buildings or indoor environments can block the satellite signal. Therefore, many indoor positioning methods have been developed to respond to this issue. In addition to the distance measurements using sonar and laser sensors, this study aims to develop a method by integrating a monocular simultaneous localization and mapping (MonoSLAM) algorithm with an inertial measurement unit (IMU) to build an indoor positioning system. The MonoSLAM algorithm measures the distance (depth) between the image features and the camera. With the help of Extend Kalman Filter (EKF), MonoSLAM can provide real-time position, velocity and camera attitude in world frame. Since the feature points will not always appear and can't be trusted at any time, a wrong estimation of the features will cause the estimated position diverge. To overcome this problem, a multisensor fusion algorithm was applied in this study by using the multi-rate Kalman Filter. Finally, from the experiment results, the proposed system was verified to be able to improve the reliability and accuracy of the MonoSLAM by integrating the IMU measurements.

  15. CoMD Implementation Suite in Emerging Programming Models

    Energy Technology Data Exchange (ETDEWEB)

    2014-09-23

    CoMD-Em is a software implementation suite of the CoMD [4] proxy app using different emerging programming models. It is intended to analyze the features and capabilities of novel programming models that could help ensure code and performance portability and scalability across heterogeneous platforms while improving programmer productivity. Another goal is to provide the authors and venders with some meaningful feedback regarding the capabilities and limitations of their models. The actual application is a classical molecular dynamics (MD) simulation using either the Lennard-Jones method (LJ) or the embedded atom method (EAM) for primary particle interaction. The code can be extended to support alternate interaction models. The code is expected ro run on a wide class of heterogeneous hardware configurations like shard/distributed/hybrid memory, GPU's and any other platform supported by the underlying programming model.

  16. 基于C#的MD5加密算法的应用%Application of the MD5 algorithm based on C#

    Institute of Scientific and Technical Information of China (English)

    林宗朝

    2011-01-01

    介绍了WEB SYSTEM中的密钥安全性能。主要讨论了WEB SYSTEM中MD5加密算法,包含客户password安全性分析、MD5加密算法概述、基于C#的MD5加密应用介绍,以及IT SYSTEM中MD5算法的应用与IMPROVEMENT等问题。%The key safety properties of the WEB system is described,and the.MD5 encryption algorithm is discussed mainly including the user password security analysis,MD5 encryption algorithm summary,MD5 encryption applications based on the C# and the improvement of MD5 algorithm.

  17. The role of thyroid hormone in sleep deprivation.

    Science.gov (United States)

    Pereira, José Carlos; Andersen, Mônica Levy

    2014-03-01

    Sleep deprivation is a stressful condition, as the subject experiences feelings of inadequate well-being and exhibits impairments in his/her functioning. However, in some circumstances sleep deprivation may be crucial for survival of the individual. Most likely, complex neural circuits and hormones play a role in allowing sleep deprivation to occur. For instance, thyroid hormone activity sharply increases when an individual is in a state of sleep deprivation. We believe that this increase is central to sleep deprivation physiology. During sleep deprivation, the hypothalamic-pituitary-thyroid axis initially increases as a consequence of increased release of thyroid stimulating hormone from the pituitary. Subsequently, as sleep deprivation continues, the sympathetic nervous system is recruited through its anatomical connection with the thyroid gland. While thyroid stimulating hormone levels markedly increase during sleep deprivation, it has been suggested that these increases are secondary to sleep deprivation. However, there is little evidence to support this assumption. We believe that the physiology of the thyroid axis during sleep deprivation and the actions of the effector hormone thyroid hormone suggest that thyroid hormone inhibits sleep and not the contrary. To our knowledge, few studies have addressed the possible neural functions that enable sleep deprivation. In this article, we discuss the hypothesis that an augmentation in the thyroid hormone axis is central to a subject's ability to curtail sleep.

  18. BayesMD: flexible biological modeling for motif discovery

    DEFF Research Database (Denmark)

    Tang, Man-Hung Eric; Krogh, Anders; Winther, Ole

    2008-01-01

    We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained on trans......We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained...

  19. Restructuring the syllabus for MD Pharmacology: Retrospection of bioassay

    Directory of Open Access Journals (Sweden)

    Sarita Mulkalwar

    2014-01-01

    Full Text Available Introduction: Career prospects in Pharmacology are witnessing a sea change due to fast and unanticipated development in the field of clinical research. Numerous openings exist now in academia, pharmaceutical industry, Clinical Research Organizations (CRO or as regulatory consultants, experimental pharmacologists, etc. In short, there are various options to choose from, depending on one′s interest. It′s high time we ponder now over the training programme for post-graduate students in Pharmacology. It needs to be revised keeping in mind the job prospects & uniqueness of the MD Pharmacology degree. Aim: To take suggestions of experienced pharmacologists on the present syllabus for MD Pharmacology and their opinion on continuation of Bioassay experiment which is currently an important part of it . Materials and Methods: A structured questionnaire was given to 30 experienced pharmacologists to seek their opinion on MD Pharmacology syllabus & continuation of Bioassay as a part of MD practical. Results: Out of 30 participants, 29 (96.6% did not use their knowledge of Bioassay during their 10 years of post MD career, whether in pharmaceutical industry or in academics. Only 5 of them (16.6% feel that experiment on bioassay should be continued in the current state. 76.7% of them wish it to be modified to a Dose Response Curve ( DRC . 6.71% feel that it should be totally scrapped. All the participants feel the need of revising current MD Pharmacology syllabus. Current syllabus is inclined more towards preparing good academicians but it lacks the proper training for creating good clinical research professionals. Medical writing, writing necessary documents for clinical trials including regulatory documents, writing an article for medical journals, marketing communication, product monograph and patient information of a clinical trial could be incorporated. They should be aware of the regulatory requirements for conducting studies on investigational drugs

  20. BI MD Studies on June 29th 2011

    CERN Document Server

    Belohrad, D; Bravin, E; Calvo, E; Dehning, B; Emery, J; Favier, M; Gras, JJ; Guerrero, A; Jeff, A; Lefevre, T; Rabiller, A; Roncarolo, F; Sapinski, M; Soby, L; Steinhagen, R

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 29-June-2011 (from 10 p.m. to 07 a.m.), dedicated to study Beam Current Monitors (BCT), Wire Scaners (WS), Synchrotron Radiation (BSRT), Beam Position (BPM), Wall Current (WCM) and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors. At the same time, it was possible to perform calibration studies with the Abort Gap (AGM) and Longitudinal Density (LDM) monitors that share the extracted light with the BSRT. Additionally some observations about the beam stability and emittance dependence on the chromaticity were performed.

  1. Form-deprivation myopia induces decreased expression of bone morphogenetic protein-2, 5 in guinea pig sclera

    Institute of Scientific and Technical Information of China (English)

    Qing; Wang; Mei-Lan; Xue; Gui-Qiu; Zhao; Mei-Guang; Liu; Yu-Na; Ma; Yan; Ma

    2015-01-01

    AIM: To identify the presence of various bone morphogenetic proteins(BMPs) and their receptors in normal sclera of human, rat and guinea pigs, and to determine whether their expression changed with form-deprivation myopia(FDM) in guinea pig sclera.METHODS: The expression of BMPs and BMP receptors were detected using reverse transcription polymerase chain reaction(RT-PCR) and immunofluorescence. Two-week-old guinea pigs were monocularly form-deprived with a translucent lens. After fourteen days induction of FDM, total RNA was isolated and subjected to RT-PCR to examine the changes of BMPs and BMP receptors in tissues from the posterior sclera. Western blotting analysis was used to investigate their changes in protein levels.RESULTS: Human sclera expressed m RNAs for BMP-2,-4,-5,-7,-RIA,-RIB and BMP-RII. Conversely, rat sclera only expressed m RNA for BMP-7 and BMP-RIB,while the expression of BMPs and BMP receptors in guinea pigs were similar to that of humans. Human sclera also expresses BMP-2,-4,-5,-7 in protein level.Fourteen days after the induction of myopia, significant decreased expressions for BMP-2 and BMP-5 in the posterior sclera of FDM-affected eyes(P <0.05 vs internal control eyes).· CONCLUSION: Various BMPs were expressed in human and guinea pig sclera. In the posterior sclera,expressions of BMP-2 and BMP-5 significantly decreased in FDM eyes. This finding indicates that various BMPs as components of the scleral cytokines regulating tissue homeostasis and provide evidence that alterations in the expression of BMP-2 and BMP-5 are associated with sclera remodeling during myopia induction.

  2. Effects of a human VEGF antibody (Bevacizumab) on deprivation myopia and choroidal thickness in the chicken.

    Science.gov (United States)

    Mathis, Ute; Ziemssen, Focke; Schaeffel, Frank

    2014-10-01

    Vascular endothelial growth factor (VEGF) is a dimeric glycoprotein which is responsible for neovascularization and fenestrations of the choriocapillaris. In neovascular maculopathies secondary to age-related degeneration (nAMD) or pathologic myopia (PM-CNV), its inhibition by humanized antibodies is currently the most successful therapy. The choroid has an important role in maintaining retinal health and its thickness declines with age and with myopia. Since choroidal thickness depends on its perfusion rate, one would expect that anti-VEGF agents can also change choroidal thickness. We have tested the hypothesis in the chicken model, using a humanized antibody, Bevacizumab, and also studied the distribution of VEGF-A in the chicken fundal layers by immunohistochemical techniques. Even though it was raised against human VEGF, Bevacizumab had several long lasting effects in the chicken eye (1) after a single unilateral intravitreal injection of 0.5 mg, it partially suppressed the development of deprivation myopia, similarly in both eyes, (2) it completely suppressed choroidal thickening that normally occurs when eyes recover from induced myopia over a time period of about 10 days, (3) it had little effect on the choroidal thickness in eyes that had normal visual experience, (4) VEGF-A was absent in sclera, but highly expressed in the walls of choroidal blood vessels and presumed nerve fiber bundles, as well as in retinal photoreceptors and cells of the inner and outer nuclear layer. One day after the injection of Bevacizumab, the immunoreactivity against VEGF-A had largely disappeared. In conclusion, Bevacizumab is similary effective in human and chicken tissue, has similar time constants (few days), has almost symmetrical effects on myopia in both eyes even after monocular application, and fully suppresses choroidal thickening that normally occurs during recovery from deprivation myopia. The mechanisms by which Bevacizumab acts on the choroidal thickness are

  3. Maternal deprivation and adolescent cannabinoid exposure impact hippocampal astrocytes, CB1 receptors and brain-derived neurotrophic factor in a sexually dimorphic fashion.

    Science.gov (United States)

    López-Gallardo, M; López-Rodríguez, A B; Llorente-Berzal, Á; Rotllant, D; Mackie, K; Armario, A; Nadal, R; Viveros, M-P

    2012-03-01

    We have recently reported that early maternal deprivation (MD) for 24 h [postnatal day (PND) 9-10] and/or an adolescent chronic treatment with the cannabinoid agonist CP-55,940 (CP) [0.4 mg/kg, PND 28-42] in Wistar rats induced, in adulthood, diverse sex-dependent long-term behavioral and physiological modifications. Here we show the results obtained from investigating the immunohistochemical analysis of CB1 cannabinoid receptors, glial fibrillary acidic protein (GFAP) positive (+) cells and brain-derived neurotrophic factor (BDNF) expression in the hippocampus of the same animals. MD induced, in males, a significant increase in the number of GFAP+ cells in CA1 and CA3 areas and in the polymorphic layer of the dentate gyrus (DG), an effect that was attenuated by CP in the two latter regions. Adolescent cannabinoid exposure induced, in control non-deprived males, a significant increase in the number of GFAP+ cells in the polymorphic layer of the DG. MD induced a decrease in CB1 expression in both sexes, and this effect was reversed in males by the cannabinoid treatment. In turn, the drug "per se" induced, in males, a general decrease in CB1 immunoreactivity, and the opposite effect was observed in females. Cannabinoid exposure tended to reduce BDNF expression in CA1 and CA3 of females, whereas MD counteracted this trend and induced an increase of BDNF in females. As a whole, the present results show sex-dependent long-term effects of both MD and juvenile cannabinoid exposure as well as functional interactions between the two treatments.

  4. Improved Collision Attack on Hash Function MD5

    Institute of Scientific and Technical Information of China (English)

    Jie Liang; Xue-Jia Lai

    2007-01-01

    In this paper, we present a fast attack algorithm to find two-block collision of hash function MD5.The algorithm is based on the two-block collision differential path of MD5 that was presented by Wang et al.In the Conference EUROCRYPT 2005.We found that the derived conditions for the desired collision differential path were not sufficient to guarantee the path to hold and that some conditions could be modified to enlarge the collision set.By using technique of small range searching and omitting the computing steps to check the characteristics in the attack algorithm, we can speed up the attack of MD5 efficiently.Compared with the Advanced Message Modification technique presented by Wang et al.,the small range searching technique can correct 4 more conditions for the first iteration differential and 3 more conditions for the second iteration differential, thus improving the probability and the complexity to find collisions.The whole attack on the MD5 can be accomplished within 5 hours using a PC with Pentium4 1.70GHz CPU.

  5. Biomolecular recognition mechanisms studied by NMR spectroscopy and MD simulations

    NARCIS (Netherlands)

    Hsu, Shang-Te Danny

    2004-01-01

    This thesis describes the use of solution Nuclear Magnetic Resonance (NMR) spectroscopy and Molecular Dynamics (MD) simulations to study the mechanism of biomolecular recognition with two model systems: i) lipid II-binding lantibiotics (lanthionine-containing antibiotics) and ii) the human immunodef

  6. 77 FR 12476 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2012-03-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore..., across Curtis Creek, mile 1.0, at Baltimore, MD. This deviation allows the bridge to operate on...

  7. 75 FR 54069 - Drawbridge Operation Regulations; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-09-03

    ... (75 FR 30747-30750). The rulemaking concerned eliminating the need for a bridge tender by allowing the... SECURITY Coast Guard 33 CFR Part 117 RIN 1625--AA09 Drawbridge Operation Regulations; Curtis Creek... Avenue Bridge, at mile 0.9, across Curtis Creek at Baltimore, MD. The requested change would have...

  8. 75 FR 1705 - Drawbridge Operation Regulations; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-01-13

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulations; Curtis Creek... operation of the I695 Bridge across Curtis Creek, mile 0.9, at Baltimore, MD. The deviation is necessary to... section of Curtis Creek and the bridge will not be able to open in the event of an emergency. Coast...

  9. 75 FR 50707 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-08-17

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore... operation of the Pennington Avenue Bridge, across Curtis Creek, mile 0.9, at Baltimore, MD. This deviation... vessels bound for the Coast Guard Yard at Curtis Bay, as well as a significant amount of commercial...

  10. QM/MM-MD simulations of conjugated polyelectrolytes

    DEFF Research Database (Denmark)

    Sjöqvist, Jonas; Linares, Mathieu; Mikkelsen, Kurt Valentin

    2014-01-01

    description of the solvent in its electronic ground state as well as the chromophore in its electronic ground and excited states, (ii) a conformational sampling by means of classical molecular dynamics (MD) in the respective electronic states, and (iii) spectral response calculations by means of the quantum...

  11. 77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-12-12

    ... Regulation; Bear Creek, Dundalk, MD'' in the Federal Register (77 FR 5201). The rulemaking concerned would... proposed rulemaking the bridge owner displayed on the Wise Avenue Bridge signage that stated a 48-hour advance notice was required to open the draw bridge. This signage portrayed improper...

  12. 78 FR 65180 - Airworthiness Directives; MD Helicopters, Inc., Helicopters

    Science.gov (United States)

    2013-10-31

    ... condition, vibration, loss of tail rotor pitch control, and loss of directional control of the helicopter...-047-AD; Amendment 39-17606; AD 2013-19-24] RIN 2120-AA64 Airworthiness Directives; MD Helicopters, Inc., Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We...

  13. 78 FR 27867 - Airworthiness Directives; MD Helicopters Inc. Helicopters

    Science.gov (United States)

    2013-05-13

    ..., leading to vibration, loss of tail rotor pitch control, and subsequent loss of tail rotor and helicopter... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; MD Helicopters Inc. Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking...

  14. A designed TLR4/MD-2 complex to capture LPS.

    Science.gov (United States)

    Brandl, Katharina; Glück, Thomas; Hartmann, Pia; Salzberger, Bernd; Falk, Werner

    2005-01-01

    The family of Toll-like receptors (TLRs) is involved in the defense of an organism to microbial attack. TLR4-induced signaling is involved in infectious diseases, chronic inflammatory diseases and sepsis; therefore, we aimed at modulating TLR4-signaling via ligand-binding soluble receptors. Because recognition of microbial structures shows some species-specific traits, we specifically selected the mouse model for later in vivo studies. We first prepared the N-terminally Flag-tagged mouse (m) recombinant (r) soluble (s) fusion proteins mrsTLR4-IgGFc (T4Fc) and mrsMD-2 in Drosophila melanogaster Schneider 2 (S2) cells. The function of these molecules was tested by inhibition of synthesis of pro-inflammatory cytokines after stimulation of mouse macrophage RAW 264.7 cells with purified lipopolysaccharide (LPS). T4Fc alone had no inhibitory activity; however, a T4Fc/MD-2 complex blocked LPS activity. By analogy with 'cytokine traps', we then prepared a designer molecule (LPS-Trap) by fusing MD-2 to the C-terminus of soluble TLR4 via a flexible linker. LPS-Trap significantly inhibited TNF production by LPS-stimulated RAW 264.7 cells. Thus, the T4Fc/MD-2 complex as well as the LPS-Trap blocked LPS activity in vitro and might thus represent a new therapeutic option in sepsis by neutralization of TLR4-activating ligands.

  15. Physical Properties of Near-Earth Asteroid 2011 MD

    NARCIS (Netherlands)

    Mommert, M.; Farnocchia, D.; Hora, J. L.; Chesley, S. R.; Trilling, D. E.; Chodas, P. W.; Mueller, M.; Harris, A. W.; Smith, H. A.; Fazio, G. G.

    2014-01-01

    We report on observations of near-Earth asteroid 2011 MD with the Spitzer Space Telescope. We have spent 19.9 h of observing time with channel 2 (4.5 {\\mu}m) of the Infrared Array Camera and detected the target within the 2{\\sigma} positional uncertainty ellipse. Using an asteroid thermophysical mod

  16. MD SIMULATION OF SUBTILISIN BPN' IN A CRYSTAL ENVIRONMENT

    NARCIS (Netherlands)

    HEINER, AP; BERENDSEN, HJC; VANGUNSTEREN, WF

    1992-01-01

    In this paper we present a molecular dynamics (MD) simulation of subtilisin BPN' in a crystalline environment containing four protein molecules and solvent. Conformational and dynamic properties of the molecules are compared with each other and with respect to the X-ray structure to test the validit

  17. Physical Properties of Near-Earth Asteroid 2011 MD

    NARCIS (Netherlands)

    Mommert, M.; Farnocchia, D.; Hora, J. L.; Chesley, S. R.; Trilling, D. E.; Chodas, P. W.; Mueller, M.; Harris, A. W.; Smith, H. A.; Fazio, G. G.

    2014-01-01

    We report on observations of near-Earth asteroid 2011 MD with the Spitzer Space Telescope. We have spent 19.9 h of observing time with channel 2 (4.5 {\\mu}m) of the Infrared Array Camera and detected the target within the 2{\\sigma} positional uncertainty ellipse. Using an asteroid thermophysical

  18. Relative deprivation between neighbouring wards is predictive of coronary heart disease mortality after adjustment for absolute deprivation of wards.

    Science.gov (United States)

    Allender, Steven; Scarborough, Peter; Keegan, Thomas; Rayner, Mike

    2012-09-01

    The aims of this study were to assess whether deprivation inequality at small area level in England is associated with coronary heart disease (CHD) mortality rates and to assess whether this provides evidence of an association between area-level and individual-level risk. Mortality rates for all wards in England were calculated using all CHD deaths between 2001 and 2006. Ward-level deprivation was measured using the Carstairs Index. Deprivation inequality within local authorities (LAs) was measured by the IQR of deprivation for wards within the LA. Relative deprivation for wards was measured as the modulus of the difference between deprivation for the ward and average deprivation for all neighbouring wards. Deprivation inequality within LAs was positively associated with CHD mortality rates per 100000 (eg, all men β; 95% CI=2.7; 1.1 to 4.3) after adjustment for absolute deprivation (pRelative deprivation for wards was positively associated with CHD mortality rates per 100000 (eg, all men 1.4; 0.7 to 2.1) after adjustment for absolute deprivation (prelative deprivation was independently associated with CHD mortality rates in both affluent and deprived wards. Rich wards surrounded by poor areas have higher CHD mortality rates than rich wards surrounded by rich areas, and poor wards surrounded by rich areas have worse CHD mortality rates than poor wards surrounded by poor areas. Local deprivation inequality has a similar adverse impact on both rich and poor areas, supporting the hypothesis that income inequality of an area has an impact on individual-level health outcomes.

  19. Obstacle Detection and Avoidance System Based on Monocular Camera and Size Expansion Algorithm for UAVs

    Science.gov (United States)

    Al-Kaff, Abdulla; García, Fernando; Martín, David; De La Escalera, Arturo; Armingol, José María

    2017-01-01

    One of the most challenging problems in the domain of autonomous aerial vehicles is the designing of a robust real-time obstacle detection and avoidance system. This problem is complex, especially for the micro and small aerial vehicles, that is due to the Size, Weight and Power (SWaP) constraints. Therefore, using lightweight sensors (i.e., Digital camera) can be the best choice comparing with other sensors; such as laser or radar.For real-time applications, different works are based on stereo cameras in order to obtain a 3D model of the obstacles, or to estimate their depth. Instead, in this paper, a method that mimics the human behavior of detecting the collision state of the approaching obstacles using monocular camera is proposed. The key of the proposed algorithm is to analyze the size changes of the detected feature points, combined with the expansion ratios of the convex hull constructed around the detected feature points from consecutive frames. During the Aerial Vehicle (UAV) motion, the detection algorithm estimates the changes in the size of the area of the approaching obstacles. First, the method detects the feature points of the obstacles, then extracts the obstacles that have the probability of getting close toward the UAV. Secondly, by comparing the area ratio of the obstacle and the position of the UAV, the method decides if the detected obstacle may cause a collision. Finally, by estimating the obstacle 2D position in the image and combining with the tracked waypoints, the UAV performs the avoidance maneuver. The proposed algorithm was evaluated by performing real indoor and outdoor flights, and the obtained results show the accuracy of the proposed algorithm compared with other related works. PMID:28481277

  20. Monocular display unit for 3D display with correct depth perception

    Science.gov (United States)

    Sakamoto, Kunio; Hosomi, Takashi

    2009-11-01

    A study of virtual-reality system has been popular and its technology has been applied to medical engineering, educational engineering, a CAD/CAM system and so on. The 3D imaging display system has two types in the presentation method; one is a 3-D display system using a special glasses and the other is the monitor system requiring no special glasses. A liquid crystal display (LCD) recently comes into common use. It is possible for this display unit to provide the same size of displaying area as the image screen on the panel. A display system requiring no special glasses is useful for a 3D TV monitor, but this system has demerit such that the size of a monitor restricts the visual field for displaying images. Thus the conventional display can show only one screen, but it is impossible to enlarge the size of a screen, for example twice. To enlarge the display area, the authors have developed an enlarging method of display area using a mirror. Our extension method enables the observers to show the virtual image plane and to enlarge a screen area twice. In the developed display unit, we made use of an image separating technique using polarized glasses, a parallax barrier or a lenticular lens screen for 3D imaging. The mirror can generate the virtual image plane and it enlarges a screen area twice. Meanwhile the 3D display system using special glasses can also display virtual images over a wide area. In this paper, we present a monocular 3D vision system with accommodation mechanism, which is useful function for perceiving depth.

  1. Avoiding monocular artifacts in clinical stereotests presented on column-interleaved digital stereoscopic displays.

    Science.gov (United States)

    Serrano-Pedraza, Ignacio; Vancleef, Kathleen; Read, Jenny C A

    2016-11-01

    New forms of stereoscopic 3-D technology offer vision scientists new opportunities for research, but also come with distinct problems. Here we consider autostereo displays where the two eyes' images are spatially interleaved in alternating columns of pixels and no glasses or special optics are required. Column-interleaved displays produce an excellent stereoscopic effect, but subtle changes in the angle of view can increase cross talk or even interchange the left and right eyes' images. This creates several challenges to the presentation of cyclopean stereograms (containing structure which is only detectable by binocular vision). We discuss the potential artifacts, including one that is unique to column-interleaved displays, whereby scene elements such as dots in a random-dot stereogram appear wider or narrower depending on the sign of their disparity. We derive an algorithm for creating stimuli which are free from this artifact. We show that this and other artifacts can be avoided by (a) using a task which is robust to disparity-sign inversion-for example, a disparity-detection rather than discrimination task-(b) using our proposed algorithm to ensure that parallax is applied symmetrically on the column-interleaved display, and (c) using a dynamic stimulus to avoid monocular artifacts from motion parallax. In order to test our recommendations, we performed two experiments using a stereoacuity task implemented with a parallax-barrier tablet. Our results confirm that these recommendations eliminate the artifacts. We believe that these recommendations will be useful to vision scientists interested in running stereo psychophysics experiments using parallax-barrier and other column-interleaved digital displays.

  2. Visual task performance using a monocular see-through head-mounted display (HMD) while walking.

    Science.gov (United States)

    Mustonen, Terhi; Berg, Mikko; Kaistinen, Jyrki; Kawai, Takashi; Häkkinen, Jukka

    2013-12-01

    A monocular see-through head-mounted display (HMD) allows the user to view displayed information while simultaneously interacting with the surrounding environment. This configuration lets people use HMDs while they are moving, such as while walking. However, sharing attention between the display and environment can compromise a person's performance in any ongoing task, and controlling one's gait may add further challenges. In this study, the authors investigated how the requirements of HMD-administered visual tasks altered users' performance while they were walking. Twenty-four university students completed 3 cognitive tasks (high- and low-working memory load, visual vigilance) on an HMD while seated and while simultaneously performing a paced walking task in a controlled environment. The results show that paced walking worsened performance (d', reaction time) in all HMD-administered tasks, but visual vigilance deteriorated more than memory performance. The HMD-administered tasks also worsened walking performance (speed, path overruns) in a manner that varied according to the overall demands of the task. These results suggest that people's ability to process information displayed on an HMD may worsen while they are in motion. Furthermore, the use of an HMD can critically alter a person's natural performance, such as their ability to guide and control their gait. In particular, visual tasks that involve constant monitoring of the HMD should be avoided. These findings highlight the need for careful consideration of the type and difficulty of information that can be presented through HMDs while still letting the user achieve an acceptable overall level of performance in various contexts of use. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  3. Obstacle Detection and Avoidance System Based on Monocular Camera and Size Expansion Algorithm for UAVs.

    Science.gov (United States)

    Al-Kaff, Abdulla; García, Fernando; Martín, David; De La Escalera, Arturo; Armingol, José María

    2017-05-07

    One of the most challenging problems in the domain of autonomous aerial vehicles is the designing of a robust real-time obstacle detection and avoidance system. This problem is complex, especially for the micro and small aerial vehicles, that is due to the Size, Weight and Power (SWaP) constraints. Therefore, using lightweight sensors (i.e., Digital camera) can be the best choice comparing with other sensors; such as laser or radar.For real-time applications, different works are based on stereo cameras in order to obtain a 3D model of the obstacles, or to estimate their depth. Instead, in this paper, a method that mimics the human behavior of detecting the collision state of the approaching obstacles using monocular camera is proposed. The key of the proposed algorithm is to analyze the size changes of the detected feature points, combined with the expansion ratios of the convex hull constructed around the detected feature points from consecutive frames. During the Aerial Vehicle (UAV) motion, the detection algorithm estimates the changes in the size of the area of the approaching obstacles. First, the method detects the feature points of the obstacles, then extracts the obstacles that have the probability of getting close toward the UAV. Secondly, by comparing the area ratio of the obstacle and the position of the UAV, the method decides if the detected obstacle may cause a collision. Finally, by estimating the obstacle 2D position in the image and combining with the tracked waypoints, the UAV performs the avoidance maneuver. The proposed algorithm was evaluated by performing real indoor and outdoor flights, and the obtained results show the accuracy of the proposed algorithm compared with other related works.

  4. Joint optic disc and cup boundary extraction from monocular fundus images.

    Science.gov (United States)

    Chakravarty, Arunava; Sivaswamy, Jayanthi

    2017-08-01

    Accurate segmentation of optic disc and cup from monocular color fundus images plays a significant role in the screening and diagnosis of glaucoma. Though optic cup is characterized by the drop in depth from the disc boundary, most existing methods segment the two structures separately and rely only on color and vessel kink based cues due to the lack of explicit depth information in color fundus images. We propose a novel boundary-based Conditional Random Field formulation that extracts both the optic disc and cup boundaries in a single optimization step. In addition to the color gradients, the proposed method explicitly models the depth which is estimated from the fundus image itself using a coupled, sparse dictionary trained on a set of image-depth map (derived from Optical Coherence Tomography) pairs. The estimated depth achieved a correlation coefficient of 0.80 with respect to the ground truth. The proposed segmentation method outperformed several state-of-the-art methods on five public datasets. The average dice coefficient was in the range of 0.87-0.97 for disc segmentation across three datasets and 0.83 for cup segmentation on the DRISHTI-GS1 test set. The method achieved a good glaucoma classification performance with an average AUC of 0.85 for five fold cross-validation on RIM-ONE v2. We propose a method to jointly segment the optic disc and cup boundaries by modeling the drop in depth between the two structures. Since our method requires a single fundus image per eye during testing it can be employed in the large-scale screening of glaucoma where expensive 3D imaging is unavailable. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Monocular distance estimation with optical flow maneuvers and efference copies: a stability-based strategy.

    Science.gov (United States)

    de Croon, Guido C H E

    2016-01-07

    The visual cue of optical flow plays an important role in the navigation of flying insects, and is increasingly studied for use by small flying robots as well. A major problem is that successful optical flow control seems to require distance estimates, while optical flow is known to provide only the ratio of velocity to distance. In this article, a novel, stability-based strategy is proposed for monocular distance estimation, relying on optical flow maneuvers and knowledge of the control inputs (efference copies). It is shown analytically that given a fixed control gain, the stability of a constant divergence control loop only depends on the distance to the approached surface. At close distances, the control loop starts to exhibit self-induced oscillations. The robot can detect these oscillations and hence be aware of the distance to the surface. The proposed stability-based strategy for estimating distances has two main attractive characteristics. First, self-induced oscillations can be detected robustly by the robot and are hardly influenced by wind. Second, the distance can be estimated during a zero divergence maneuver, i.e., around hover. The stability-based strategy is implemented and tested both in simulation and on board a Parrot AR drone 2.0. It is shown that the strategy can be used to: (1) trigger a final approach response during a constant divergence landing with fixed gain, (2) estimate the distance in hover, and (3) estimate distances during an entire landing if the robot uses adaptive gain control to continuously stay on the 'edge of oscillation.'

  6. Early maternal deprivation immunologically primes hippocampal synapses by redistributing interleukin-1 receptor type I in a sex dependent manner.

    Science.gov (United States)

    Viviani, Barbara; Boraso, Mariaserena; Valero, Manuel; Gardoni, Fabrizio; Marco, Eva Maria; Llorente, Ricardo; Corsini, Emanuela; Galli, Corrado Lodovico; Di Luca, Monica; Marinovich, Marina; López-Gallardo, Meritxell; Viveros, Maria-Paz

    2014-01-01

    Challenges experienced in early life cause an enduring phenotypical shift of immune cells towards a sensitised state that may lead to an exacerbated reaction later in life and contribute to increased vulnerability to neurological diseases. Peripheral and central inflammation may affect neuronal function through cytokines such as IL-1. The extent to which an early life challenge induces long-term alteration of immune receptors organization in neurons has not been shown. We investigated whether a single episode of maternal deprivation (MD) on post-natal day (PND) 9 affects: (i) the synapse distribution of IL-1RI together with subunits of NMDA and AMPA receptors; and (ii) the interactions between IL-1RI and the GluN2B subunit of the NMDAR in the long-term, at PND 45. MD increased IL-1RI levels and IL-1RI interactions with GluN2B at the synapse of male hippocampal neurons, without affecting the total number of IL-1RI or NMDAR subunits. Although GluN2B and GluN2A were slightly but not significantly changed at the synapse, their ratio was significantly decreased in the hippocampus of the male rats who had experienced MD; the levels of the GluA1 and GluA2 subunits of the AMPAR were also decreased. These changes were not observed immediately after the MD episode. None of the observed alterations occurred in the hippocampus of the females or in the prefrontal cortex of either sex. These data reveal a long-term, sex-dependent modification in receptor organisation at the hippocampal post-synapses following MD. We suggest that this effect might contribute to priming hippocampal synapses to the action of IL-1β.

  7. Occupational deprivation in an asylum centre:

    DEFF Research Database (Denmark)

    Morville, Anne-Le; Erlandsson, Lena-Karin

    2013-01-01

    This article presents a study of three asylum-seeking men from Iran and Afghanistan. It aimed to explore how and if they experienced occupations as occupations in a Danish asylum centre and how their life experience shaped their choice and value of current occupations. In-depth narrative interviews...... explored the participants’ occupational history and its influence on their occupations in the asylum centre. A thematic analysis showed that the participants had been subjected to occupational disruption and deprivation by politically oppressive systems even before their flight. Their occupations...... in Denmark were to a certain extent influenced by their earlier occupations and the current occupational deprivation they all experienced was due to limited possibilities in the centre. Although they tried their best to fill their days and create structure, there was a loss of valued occupations...

  8. Human reproductive cloning and reasons for deprivation.

    Science.gov (United States)

    Jensen, D A

    2008-08-01

    Human reproductive cloning provides the possibility of genetically related children for persons for whom present technologies are ineffective. I argue that the desire for genetically related children is not, by itself, a sufficient reason to engage in human reproductive cloning. I show this by arguing that the value underlying the desire for genetically related children implies a tension between the parent and the future child. This tension stems from an instance of a deprivation and violates a general principle of reasons for deprivation. Alternative considerations, such as a right to procreative autonomy, do not appear helpful in making the case for human reproductive cloning merely on the basis of the desire for genetically related children.

  9. Duality in binocular rivalry: distinct sensitivity of percept sequence and percept duration to imbalance between monocular stimuli.

    Directory of Open Access Journals (Sweden)

    Chen Song

    Full Text Available BACKGROUND: Visual perception is usually stable and accurate. However, when the two eyes are simultaneously presented with conflicting stimuli, perception falls into a sequence of spontaneous alternations, switching between one stimulus and the other every few seconds. Known as binocular rivalry, this visual illusion decouples subjective experience from physical stimulation and provides a unique opportunity to study the neural correlates of consciousness. The temporal properties of this alternating perception have been intensively investigated for decades, yet the relationship between two fundamental properties - the sequence of percepts and the duration of each percept - remains largely unexplored. METHODOLOGY/PRINCIPAL FINDINGS: Here we examine the relationship between the percept sequence and the percept duration by quantifying their sensitivity to the strength imbalance between two monocular stimuli. We found that the percept sequence is far more susceptible to the stimulus imbalance than does the percept duration. The percept sequence always begins with the stronger stimulus, even when the stimulus imbalance is too weak to cause a significant bias in the percept duration. Therefore, introducing a small stimulus imbalance affects the percept sequence, whereas increasing the imbalance affects the percept duration, but not vice versa. To investigate why the percept sequence is so vulnerable to the stimulus imbalance, we further measured the interval between the stimulus onset and the first percept, during which subjects experienced the fusion of two monocular stimuli. We found that this interval is dramatically shortened with increased stimulus imbalance. CONCLUSIONS/SIGNIFICANCE: Our study shows that in binocular rivalry, the strength imblanace between monocular stimuli has a much greater impact on the percept sequence than on the percept duration, and increasing this imbalance can accelerate the process responsible for the percept sequence.

  10. Cues of fatigue: effects of sleep deprivation on facial appearance.

    Science.gov (United States)

    Sundelin, Tina; Lekander, Mats; Kecklund, Göran; Van Someren, Eus J W; Olsson, Andreas; Axelsson, John

    2013-09-01

    To investigate the facial cues by which one recognizes that someone is sleep deprived versus not sleep deprived. Experimental laboratory study. Karolinska Institutet, Stockholm, Sweden. Forty observers (20 women, mean age 25 ± 5 y) rated 20 facial photographs with respect to fatigue, 10 facial cues, and sadness. The stimulus material consisted of 10 individuals (five women) photographed at 14:30 after normal sleep and after 31 h of sleep deprivation following a night with 5 h of sleep. Ratings of fatigue, fatigue-related cues, and sadness in facial photographs. The faces of sleep deprived individuals were perceived as having more hanging eyelids, redder eyes, more swollen eyes, darker circles under the eyes, paler skin, more wrinkles/fine lines, and more droopy corners of the mouth (effects ranging from b = +3 ± 1 to b = +15 ± 1 mm on 100-mm visual analog scales, P sleep deprivation (P sleep deprivation, nor associated with judgements of fatigue. In addition, sleep-deprived individuals looked sadder than after normal sleep, and sadness was related to looking fatigued (P sleep deprivation affects features relating to the eyes, mouth, and skin, and that these features function as cues of sleep loss to other people. Because these facial regions are important in the communication between humans, facial cues of sleep deprivation and fatigue may carry social consequences for the sleep deprived individual in everyday life.

  11. Sleep deprivation of rats: the hyperphagic response is real.

    Science.gov (United States)

    Koban, Michael; Sita, Luciane V; Le, Wei Wei; Hoffman, Gloria E

    2008-07-01

    Chronic sleep deprivation of rats causes hyperphagia without body weight gain. Sleep deprivation hyperphagia is prompted by changes in pathways governing food intake; hyperphagia may be adaptive to sleep deprivation hypermetabolism. A recent paper suggested that sleep deprivation might inhibit ability of rats to increase food intake and that hyperphagia may be an artifact of uncorrected chow spillage. To resolve this, a palatable liquid diet (Ensure) was used where spillage is insignificant. Sleep deprivation of male Sprague Dawley rats was enforced for 10 days by the flowerpot/platform paradigm. Daily food intake and body weight were measured. On day 10, rats were transcardially perfused for analysis of hypothalamic mRNA expression of the orexigen, neuropeptide Y (NPY). Morgan State University, sleep deprivation and transcardial perfusion; University of Maryland, NPY in situ hybridization and analysis. Using a liquid diet for accurate daily measurements, there was no change in food intake in the first 5 days of sleep deprivation. Importantly, from days 6-10 it increased significantly, peaking at 29% above baseline. Control rats steadily gained weight but sleep-deprived rats did not. Hypothalamic NPY mRNA levels were positively correlated to stimulation of food intake and negatively correlated with changes in body weight. Sleep deprivation hyperphagia may not be apparent over the short term (i.e., weight and food intake suggests that the negative energy balance induced by sleep deprivation prompts the neural changes that evoke hyperphagia.

  12. Sleep deprivation increases formation of false memory.

    Science.gov (United States)

    Lo, June C; Chong, Pearlynne L H; Ganesan, Shankari; Leong, Ruth L F; Chee, Michael W L

    2016-12-01

    Retrieving false information can have serious consequences. Sleep is important for memory, but voluntary sleep curtailment is becoming more rampant. Here, the misinformation paradigm was used to investigate false memory formation after 1 night of total sleep deprivation in healthy young adults (N = 58, mean age ± SD = 22.10 ± 1.60 years; 29 males), and 7 nights of partial sleep deprivation (5 h sleep opportunity) in these young adults and healthy adolescents (N = 54, mean age ± SD = 16.67 ± 1.03 years; 25 males). In both age groups, sleep-deprived individuals were more likely than well-rested persons to incorporate misleading post-event information into their responses during memory retrieval (P sleep in optimal cognitive functioning, reveal the vulnerability of adolescents' memory during sleep curtailment, and suggest the need to assess eyewitnesses' sleep history after encountering misleading information. © 2016 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.

  13. Relative deprivation and sickness absence in Sweden.

    Science.gov (United States)

    Helgertz, Jonas; Hess, Wolfgang; Scott, Kirk

    2013-08-29

    A high prevalence of sickness absence in many countries, at a substantial societal cost, underlines the importance to understand its determining mechanisms. This study focuses on the link between relative deprivation and the probability of sickness absence. 184,000 men and women in Sweden were followed between 1982 and 2001. The sample consists of working individuals between the ages of 19 and 65. The outcome is defined as experiencing more than 14 days of sickness absence during a year. Based on the complete Swedish population, an individual's degree of relative deprivation is measured through income compared to individuals of the same age, sex, educational level and type. In accounting for the possibility that sickness absence and socioeconomic status are determined by common factors, discrete-time duration models were estimated, accounting for unobserved heterogeneity through random effects. The results confirm that the failure to account for the dynamics of the individual's career biases the influence from socioeconomic characteristics. Results consistently suggest a major influence from relative deprivation, with a consistently lower risk of sickness absence among the highly educated. Altering individual's health behavior through education appears more efficient in reducing the reliance on sickness absence, rather than redistributive policies.

  14. Long-term Effects of Maternal Deprivation on the Volume, Number and Size of Neurons in the Amygdala and Nucleus Accumbens of Rats.

    Science.gov (United States)

    Aleksić, Dubravka; Aksić, Milan; Radonjić, Nevena V; Jovanović, Aleksandar; Marković, Branka; Petronijević, Nataša; Radonjić, Vidosava; Mališ, Miloš; Filipović, Branislav

    2016-09-01

    Maternal deprivation (MD) in rodents is an important neurodevelopmental model for studying a variety of behavioral changes which closely resemble the symptoms of schizophrenia in humans. To determine whether early-life stress leads to changes in the limbic system structures: the amygdala and the nucleus accumbens, 9-day-old Wistar rats were exposed to 24 hour MD. On P60 the rats were sacrificed for morphometric analysis and their brains were compared to the control group. Results show that MD affected important limbic system structures: the amygdala and the nucleus accumbens, whose volume was decreased (17% of the control value for the amygdala and 9% of the control value for the nucleus accumbens ), as well as the number of neurons (41% of the control value for the amygdala and 43% of the control value for the nucleus accumbens ) and the size of their cells soma (12% of the control value for the amygdala and 33% of the control value for the nucleus accumbens ). This study indicates that early stress in life leads to changes in the morphology of the limbic areas of the brain, most probably due to the loss of neurons during postnatal development, and it further contributes to our understanding of the effects of maternal deprivation on brain development.

  15. Sensor Fusion of Monocular Cameras and Laser Rangefinders for Line-Based Simultaneous Localization and Mapping (SLAM Tasks in Autonomous Mobile Robots

    Directory of Open Access Journals (Sweden)

    Xinzheng Zhang

    2012-01-01

    Full Text Available This paper presents a sensor fusion strategy applied for Simultaneous Localization and Mapping (SLAM in dynamic environments. The designed approach consists of two features: (i the first one is a fusion module which synthesizes line segments obtained from laser rangefinder and line features extracted from monocular camera. This policy eliminates any pseudo segments that appear from any momentary pause of dynamic objects in laser data. (ii The second characteristic is a modified multi-sensor point estimation fusion SLAM (MPEF-SLAM that incorporates two individual Extended Kalman Filter (EKF based SLAM algorithms: monocular and laser SLAM. The error of the localization in fused SLAM is reduced compared with those of individual SLAM. Additionally, a new data association technique based on the homography transformation matrix is developed for monocular SLAM. This data association method relaxes the pleonastic computation. The experimental results validate the performance of the proposed sensor fusion and data association method.

  16. The Energy Spectrum of Ultra-High-Energy Cosmic Rays Measured by the Telescope Array FADC Fluorescence Detectors in Monocular Mode

    CERN Document Server

    Abu-Zayyad, T; Allen, M; Anderson, R; Azuma, R; Barcikowski, E; Belz, J W; Bergman, D R; Blake, S A; Cady, R; Cheon, B G; Chiba, J; Chikawa, M; Cho, E J; Cho, W R; Fujii, H; Fujii, T; Fukuda, T; Fukushima, M; Hanlon, W; Hayashi, K; Hayashi, Y; Hayashida, N; Hibino, K; Hiyama, K; Honda, K; Iguchi, T; Ikeda, D; Ikuta, K; Inoue, N; Ishii, T; Ishimori, R; Ito, H; Ivanov, D; Iwamoto, S; Jui, C C H; Kadota, K; Kakimoto, F; Kalashev, O; Kanbe, T; Kasahara, K; Kawai, H; Kawakami, S; Kawana, S; Kido, E; Kim, H B; Kim, H K; Kim, J H; Kitamoto, K; Kitamura, S; Kitamura, Y; Kobayashi, K; Kobayashi, Y; Kondo, Y; Kuramoto, K; Kuzmin, V; Kwon, Y J; Lan, J; Lim, S I; Lundquist, J P; Machida, S; Martens, K; Matsuda, T; Matsuura, T; Matsuyama, T; Matthews, J N; Myers, I; Minamino, M; Miyata, K; Murano, Y; Nagataki, S; Nakamura, T; Nam, S W; Nonaka, T; Ogio, S; Ogura, J; Ohnishi, M; Ohoka, H; Oki, K; Oku, D; Okuda, T; Ono, M; Oshima, A; Ozawa, S; Park, I H; Pshirkov, M S; Rodriguez, D C; Roh, S Y; Rubtsov, G; Ryu, D; Sagawa, H; Sakurai, N; Sampson, A L; Scott, L M; Shah, P D; Shibata, F; Shibata, T; Shimodaira, H; Shin, B K; Shin, J I; Shirahama, T; Smith, J D; Sokolsky, P; Sonley, T J; Springer, R W; Stokes, B T; Stratton, S R; Stroman, T A; Suzuki, S; Takahashi, Y; Takeda, M; Taketa, A; Takita, M; Tameda, Y; Tanaka, H; Tanaka, K; Tanaka, M; Thomas, S B; Thomson, G B; Tinyakov, P; Tkachev, I; Tokuno, H; Tomida, T; Troitsky, S; Tsunesada, Y; Tsutsumi, K; Tsuyuguchi, Y; Uchihori, Y; Udo, S; Ukai, H; Vasiloff, G; Wada, Y; Wong, T; Yamakawa, Y; Yamane, R; Yamaoka, H; Yamazaki, K; Yang, J; Yoneda, Y; Yoshida, S; Yoshii, H; Zollinger, R; Zundel, Z

    2013-01-01

    We present a measurement of the energy spectrum of ultra-high-energy cosmic rays performed by the Telescope Array experiment using monocular observations from its two new FADC-based fluorescence detectors. After a short description of the experiment, we describe the data analysis and event reconstruction procedures. Since the aperture of the experiment must be calculated by Monte Carlo simulation, we describe this calculation and the comparisons of simulated and real data used to verify the validity of the aperture calculation. Finally, we present the energy spectrum calculated from the merged monocular data sets of the two FADC-based detectors, and also the combination of this merged spectrum with an independent, previously published monocular spectrum measurement performed by Telescope Array's third fluorescence detector (Abu-Zayyad {\\it et al.}, {Astropart. Phys.} 39 (2012), 109). This combined spectrum corroborates the recently published Telescope Array surface detector spectrum (Abu-Zayyad {\\it et al.}, ...

  17. Sensor fusion of monocular cameras and laser rangefinders for line-based Simultaneous Localization and Mapping (SLAM) tasks in autonomous mobile robots.

    Science.gov (United States)

    Zhang, Xinzheng; Rad, Ahmad B; Wong, Yiu-Kwong

    2012-01-01

    This paper presents a sensor fusion strategy applied for Simultaneous Localization and Mapping (SLAM) in dynamic environments. The designed approach consists of two features: (i) the first one is a fusion module which synthesizes line segments obtained from laser rangefinder and line features extracted from monocular camera. This policy eliminates any pseudo segments that appear from any momentary pause of dynamic objects in laser data. (ii) The second characteristic is a modified multi-sensor point estimation fusion SLAM (MPEF-SLAM) that incorporates two individual Extended Kalman Filter (EKF) based SLAM algorithms: monocular and laser SLAM. The error of the localization in fused SLAM is reduced compared with those of individual SLAM. Additionally, a new data association technique based on the homography transformation matrix is developed for monocular SLAM. This data association method relaxes the pleonastic computation. The experimental results validate the performance of the proposed sensor fusion and data association method.

  18. Modeling Of A Monocular, Full-Color, Laser-Scanning, Helmet-Mounted Display for Aviator Situational Awareness

    Science.gov (United States)

    2017-03-27

    USAARL Report No. 2017-10 Modeling of a Monocular, Full-Color, Laser- Scanning, Helmet-Mounted Display for Aviator Situational Awareness By Thomas...Mounted Display for Aviator Situational Awareness N/A N/A N/A N/A N/A N/A Harding, Thomas H. Raatz, Maria E. Martin, John S. Rash, Clarence E. U.S...Huntsville, AL 35806-3302 PM Air Warrior, PEO Soldier Approved for public release; distribution unlimited. The modeling data and analysis presented in

  19. Early maternal deprivation induces gender-dependent changes on the expression of hippocampal CB(1) and CB(2) cannabinoid receptors of neonatal rats.

    Science.gov (United States)

    Suárez, Juan; Llorente, Ricardo; Romero-Zerbo, Silvana Y; Mateos, Beatriz; Bermúdez-Silva, Francisco J; de Fonseca, Fernando Rodríguez; Viveros, María-Paz

    2009-07-01

    Early maternal deprivation (MD) in rats (24 h, postnatal day 9-10) is a model for neurodevelopmental stress. There are some data proving that MD affects the endocannabinoid system (ECS) in a gender-dependent manner, and that these changes may account for the proposed schizophrenia-like phenotype of MD rats. The impact of MD on cannabinoid receptor distribution in the hippocampus is unknown. The aim of this study is to evaluate the expression of CB(1) and CB(2) receptors in diverse relevant subregions (DG, CA1, and CA3) of the hippocampus in 13-day-old rats by immunohistochemistry and densitometry. MD induced a significant decrease in CB(1) immunoreactivity (more marked in males than in females), which was mainly associated with fibers in the strata pyramidale and radiatum of CA1 and in the strata oriens, pyramidale, and radiatum of CA3. In contrast, MD males and females showed a significant increase in CB(2) immunoreactivity in the three hippocampal areas analyzed that was detected in neuropil and puncta in the stratum oriens of CA1 and CA3, and in the polymorphic cell layer of the dentate gyrus. A marked sex dimorphism was observed in CA3, with females exhibiting higher CB(1) immunoreactivity than males, and in dentate gyrus, with females exhibiting lower CB(2) immunoreactivity than males. These results point to a clear association between developmental stress and dysregulation of the ECS. The present MD procedure may provide an interesting experimental model to further address the role of the ECS in neurodevelopmental mental illnesses such as schizophrenia.

  20. Loss of Binocular Vision in Monocularly Blind Patients Causes Selective Degeneration of the Superior Lateral Occipital Cortices

    NARCIS (Netherlands)

    Prins, Doety D; Jansonius, Nomdo M.; Cornelissen, Frans W.

    2017-01-01

    PURPOSE. Chronic ocular pathology, such as glaucoma and macular degeneration, is associated with neuroanatomic changes in the visual pathways. It is a challenge to determine the mechanism responsible for these changes. This could be functional deprivation or transsynaptic degeneration. Acquired

  1. Multiple Deprivation, Severity and Latent Sub-Groups: Advantages of Factor Mixture Modelling for Analysing Material Deprivation.

    Science.gov (United States)

    Najera Catalan, Hector E

    2017-01-01

    Material deprivation is represented in different forms and manifestations. Two individuals with the same deprivation score (i.e. number of deprivations), for instance, are likely to be unable to afford or access entirely or partially different sets of goods and services, while one individual may fail to purchase clothes and consumer durables and another one may lack access to healthcare and be deprived of adequate housing . As such, the number of possible patterns or combinations of multiple deprivation become increasingly complex for a higher number of indicators. Given this difficulty, there is interest in poverty research in understanding multiple deprivation, as this analysis might lead to the identification of meaningful population sub-groups that could be the subjects of specific policies. This article applies a factor mixture model (FMM) to a real dataset and discusses its conceptual and empirical advantages and disadvantages with respect to other methods that have been used in poverty research . The exercise suggests that FMM is based on more sensible assumptions (i.e. deprivation covary within each class), provides valuable information with which to understand multiple deprivation and is useful to understand severity of deprivation and the additive properties of deprivation indicators.

  2. Augmented Reality as a Countermeasure for Sleep Deprivation.

    Science.gov (United States)

    Baumeister, James; Dorrlan, Jillian; Banks, Siobhan; Chatburn, Alex; Smith, Ross T; Carskadon, Mary A; Lushington, Kurt; Thomas, Bruce H

    2016-04-01

    Sleep deprivation is known to have serious deleterious effects on executive functioning and job performance. Augmented reality has an ability to place pertinent information at the fore, guiding visual focus and reducing instructional complexity. This paper presents a study to explore how spatial augmented reality instructions impact procedural task performance on sleep deprived users. The user study was conducted to examine performance on a procedural task at six time points over the course of a night of total sleep deprivation. Tasks were provided either by spatial augmented reality-based projections or on an adjacent monitor. The results indicate that participant errors significantly increased with the monitor condition when sleep deprived. The augmented reality condition exhibited a positive influence with participant errors and completion time having no significant increase when sleep deprived. The results of our study show that spatial augmented reality is an effective sleep deprivation countermeasure under laboratory conditions.

  3. Health-Risk Behaviour in Deprived Neighbourhoods Compared with Non-Deprived Neighbourhoods

    DEFF Research Database (Denmark)

    Algren, Maria Holst; Bak, Carsten Kronborg; Berg-Beckhoff, Gabriele;

    2015-01-01

    Med, Embase, Web of Science and Sociological Abstracts using relevant search terms, Boolean operators, and truncation, and reference lists were scanned. Quantitative observational studies that examined health-risk behaviour in deprived neighbourhoods compared with non-deprived neighbourhoods were eligible......BACKGROUND: There has been increasing interest in neighbourhoods' influence on individuals' health-risk behaviours, such as smoking, alcohol consumption, physical activity and diet. The aim of this review was to systematically review recent studies on health-risk behaviour among adults who live...

  4. Functional connectivity during rested wakefulness predicts vulnerability to sleep deprivation.

    Science.gov (United States)

    Yeo, B T Thomas; Tandi, Jesisca; Chee, Michael W L

    2015-05-01

    Significant inter-individual differences in vigilance decline following sleep deprivation exist. We characterized functional connectivity in 68 healthy young adult participants in rested wakefulness and following a night of total sleep deprivation. After whole brain signal regression, functionally connected cortical networks during the well-rested state exhibited reduced correlation following sleep deprivation, suggesting that highly integrated brain regions become less integrated during sleep deprivation. In contrast, anti-correlations in the well-rested state became less so following sleep deprivation, suggesting that highly segregated networks become less segregated during sleep deprivation. Subjects more resilient to vigilance decline following sleep deprivation showed stronger anti-correlations among several networks. The weaker anti-correlations overlapped with connectivity alterations following sleep deprivation. Resilient individuals thus evidence clearer separation of highly segregated cortical networks in the well-rested state. In contrast to corticocortical connectivity, subcortical-cortical connectivity was comparable across resilient and vulnerable groups despite prominent state-related changes in both groups. Because sleep deprivation results in a significant elevation of whole brain signal amplitude, the aforesaid signal changes and group contrasts may be masked in analyses omitting their regression, suggesting possible value in regressing whole brain signal in certain experimental contexts.

  5. Integration of monocular motion signals and the analysis of interocular velocity differences for the perception of motion-in-depth.

    Science.gov (United States)

    Shioiri, Satoshi; Kakehi, Daisuke; Tashiro, Tomoyoshi; Yaguchi, Hirohisa

    2009-12-09

    We investigated how the mechanism for perceiving motion-in-depth based on interocular velocity differences (IOVDs) integrates signals from the motion spatial frequency (SF) channels. We focused on the question whether this integration is implemented before or after the comparison of the velocity signals from the two eyes. We measured spatial frequency selectivity of the MAE of motion in depth (3D MAE). The 3D MAE showed little spatial frequency selectivity, whereas the 2D lateral MAE showed clear spatial frequency selectivity in the same condition. This indicates that the outputs of the monocular motion SF channels are combined before analyzing the IOVD. The presumption was confirmed by the disappearance of the 3D MAE after exposure to superimposed gratings with different spatial frequencies moving in opposite directions. The direction of the 2D MAE depended on the test spatial frequency in the same condition. These results suggest that the IOVD is calculated at a relatively later stage of the motion analysis, and that some monocular information is preserved even after the integration of the motion SF channel outputs.

  6. Real-time drogue recognition and 3D locating for UAV autonomous aerial refueling based on monocular machine vision

    Institute of Scientific and Technical Information of China (English)

    Wang Xufeng; Kong Xingwei; Zhi Jianhui; Chen Yong; Dong Xinmin

    2015-01-01

    Drogue recognition and 3D locating is a key problem during the docking phase of the autonomous aerial refueling (AAR). To solve this problem, a novel and effective method based on monocular vision is presented in this paper. Firstly, by employing computer vision with red-ring-shape feature, a drogue detection and recognition algorithm is proposed to guarantee safety and ensure the robustness to the drogue diversity and the changes in environmental condi-tions, without using a set of infrared light emitting diodes (LEDs) on the parachute part of the dro-gue. Secondly, considering camera lens distortion, a monocular vision measurement algorithm for drogue 3D locating is designed to ensure the accuracy and real-time performance of the system, with the drogue attitude provided. Finally, experiments are conducted to demonstrate the effective-ness of the proposed method. Experimental results show the performances of the entire system in contrast with other methods, which validates that the proposed method can recognize and locate the drogue three dimensionally, rapidly and precisely.

  7. Neurobehavioral and metabolic long-term consequences of neonatal maternal deprivation stress and adolescent olanzapine treatment in male and female rats.

    Science.gov (United States)

    Llorente-Berzal, Alvaro; Mela, Virginia; Borcel, Erika; Valero, Manuel; López-Gallardo, Meritxell; Viveros, Maria-Paz; Marco, Eva M

    2012-03-01

    Early maternal deprivation (MD), 24h of dam-litter separation on postnatal day (PND) 9, has been proposed as a suitable animal model to investigate some neuropsychiatric disorders with a base in neurodevelopment that also compromises metabolic and endocrine homeostasis. Atypical antipsychotics are frequently prescribed to children and adolescents as first-line treatment for several mental disorders despite the adverse metabolic effects frequently reported. However, persistent long-term effects after adolescent drug therapy have been scarcely investigated. In the present study we aimed to investigate the long-lasting metabolic and behavioral effects of MD in combination with the administration of an atypical antipsychotic, i.e. olanzapine, during adolescence. For that purpose, male and female Wistar rats not exposed (control group, Co) and exposed to the MD protocol were administered with oral olanzapine (Olan, 7.5mg/kg/day) or vehicle (Vh, 1mM acetic acid) in drinking water from PND 28 to PND 49. Body weight gain, glycaemia and plasma triglyceride (TG) levels were evaluated as relevant metabolic parameters. MD significantly diminished body weight gain, while Olan administration only induced a subtle decrease in body weight gain among female animals in the long-term. Olan discontinuation decreased plasma TG levels in adult rats, an effect that was counteracted by neonatal exposure to the MD protocol. Both MD and Olan treatment impaired cognitive function in the novel object recognition test, although no interaction between treatments was observed. Neither MD nor Olan administration affected psychotic-related symptoms evaluated in the prepulse inhibition task, although animals treated with Olan showed an increased reactivity to the first acoustic stimulus. MD diminished the corticosterone stress-induced response among females, and reduced the expression of CB1 receptors in the hippocampus of both male and female rats. Notably, Olan administration tended to

  8. MD 382: Beam Transfer Function and diffusion mechanisms

    CERN Document Server

    Tambasco, Claudia; Buffat, Xavier; Crouch, Matthew; Pieloni, Tatiana; Boccardi, Andrea; Fuchsberger, Kajetan; Gasior, Marek; Kotzian, Gerd; Lefevre, Thibaut; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; Giachino, Rossano; CERN. Geneva. ATS Department

    2016-01-01

    The Beam Transfer Function (BTF) measurements have been previously tested in the LHC during MD block 1 and 2. Different machine configurations (i.e. energy, beam intensity, emittance etc...) have been tested to determine a safe set-up (excitation amplitude) of the system to be completely transparent to the beam (no emittance blow-up neither losses). The aim of this experiment in MD block 3 was to characterize the Stability Diagram (SD) in the presence of diffusion mechanisms induced by excited resonances due to beam-beam long range and Landau octupole interplay. During the experiment, BTF measurements have been acquired at flat top for different settings of Landau octupole current, different chromaticity values and transverse feedback gains. In this note the description of the experiment is presented together with some preliminary results.

  9. A Fast Attack Algorithm on the MD5 Hash Function

    Institute of Scientific and Technical Information of China (English)

    WANG Zhang-yi; ZHANG Huan-guo; QIN Zhong-ping; MENG Qing-shu

    2006-01-01

    The sufficient conditions for keeping desired differential path of MD5 was discussed. By analyzing the expanding of subtraction difference, differential characters of Boolean functions, and the differential characters of shift rotation, the sufficient conditions for keeping desired differential path could be obtained. From the differential characters of shift rotation, the lacked sufficient conditions were found. Then an algorithm that reduces the number of trials for finding collisions were presented. By restricting search space, search operation can be reduced tc 234 for the first block and 230 for the second block. The whole attack on the MD5 can be accomplished within 2C hours using a PC with 1.6 G CPU.

  10. MD210 Note: Creation of Hollow Bunches in the PSB

    CERN Document Server

    Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2016-01-01

    MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

  11. MD 1856 - Landau Damping: Beam Transfer Functions and diffusion mechanisms

    CERN Document Server

    Tambasco, Claudia; Boccardi, Andrea; Buffat, Xavier; Gasior, Marek; Lefevre, Thibaut; Levens, Tom; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; Pieloni, Tatiana; Crouch, Matthew Paul; CERN. Geneva. ATS Department

    2017-01-01

    In the 2012, 2015 and 2016 several instabilities were developing during the betatron squeeze where beam-beam interactions become stronger modifying the tune spread provided by the octupoles magnets. Studies of the stability area computed by evaluating the dispersion integral for different tune spread couldn’t explain the 2012 observed instabilities during the squeeze. The size of the stability area given by the computed dispersion integral depends on the transverse tune spread but its shape is defined by the particle distribution in the beams. Therefore any change of the particle distribution due to for instance a diffusion from excited resonances can lead to a deterioration of the Landau stability area. The Beam Transfer Functions (BTF) measurements are direct measurement of the Stability Diagrams (SD). They are sensitive to the particle distribution and contain information about the transverse tune spread in the beams. In this MD we wanted to verify the findings of MD 1407 and try to explain observed inst...

  12. Ground moving target geo-location from monocular camera mounted on a micro air vehicle

    Science.gov (United States)

    Guo, Li; Ang, Haisong; Zheng, Xiangming

    2011-08-01

    The usual approaches to unmanned air vehicle(UAV)-to-ground target geo-location impose some severe constraints to the system, such as stationary objects, accurate geo-reference terrain database, or ground plane assumption. Micro air vehicle(MAV) works with characteristics including low altitude flight, limited payload and onboard sensors' low accuracy. According to these characteristics, a method is developed to determine the location of ground moving target which imaged from the air using monocular camera equipped on MAV. This method eliminates the requirements for terrain database (elevation maps) and altimeters that can provide MAV's and target's altitude. Instead, the proposed method only requires MAV flight status provided by its inherent onboard navigation system which includes inertial measurement unit(IMU) and global position system(GPS). The key is to get accurate information on the altitude of the ground moving target. First, Optical flow method extracts background static feature points. Setting a local region around the target in the current image, The features which are on the same plane with the target in this region are extracted, and are retained as aided features. Then, inverse-velocity method calculates the location of these points by integrated with aircraft status. The altitude of object, which is calculated by using position information of these aided features, combining with aircraft status and image coordinates, geo-locate the target. Meanwhile, a framework with Bayesian estimator is employed to eliminate noise caused by camera, IMU and GPS. Firstly, an extended Kalman filter(EKF) provides a simultaneous localization and mapping solution for the estimation of aircraft states and aided features location which defines the moving target local environment. Secondly, an unscented transformation(UT) method determines the estimated mean and covariance of target location from aircraft states and aided features location, and then exports them for the

  13. MD 349: Impedance Localization with AC-dipole

    CERN Document Server

    Biancacci, Nicolo; Metral, Elias; Salvant, Benoit; Papotti, Giulia; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the distribution of the transverse impedance of the LHC by observing the phase advance variation with intensity between the machine BPMs. Four injected bunches with different intensities are excited with an AC dipole and the turn by turn data is acquired from the BPM system. Through post-processing analysis the phase variation along the machine is depicted and, from this information, first conclusions of the impedance distribution can be drawn.

  14. MD 1691: Active halo control using tune ripple at injection

    CERN Document Server

    Garcia Morales, Hector; Bruce, Roderik; Redaelli, Stefano; Fitterer, Miriam; Fiascaris, Maria; Nisbet, David; Thiesen, Hugues; Valentino, Gianluca; Xu, Chen; CERN. Geneva. ATS Department

    2017-01-01

    In this MD we performed halo excitation through tune ripple. This consists in an excitation that introduces new resonance sidebands around the existing resonance lines. In presence of sufficient detuning with amplitude, these sidebands can in principle affect only the dynamics of the halo particles at large amplitudes. Tune ripple was induced through a current modulation of the warm trim quadrupoles in IR7. This is the first time this method is experimentally tested at the LHC.

  15. Application of MD simulations to predict membrane properties of MOFs

    OpenAIRE

    Elda Adatoz; Seda Keskin

    2015-01-01

    Research Article Application of MD Simulations to Predict Membrane Properties of MOFs Elda Adatoz and Seda Keskin Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Sariyer, 34450 Istanbul, Turkey Correspondence should be addressed to Seda Keskin; Received 22 May 2015; Accepted 13 July 2015 Academic Editor: Yanlin Song Copyright © 2015 E. Adatoz and S. Keskin. This is an open access article distributed under the Creative Commons A...

  16. Analytical applications of MD-FIA-optical detection systems

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A brief introduction of recent research works in our laboratory concerning microdialysis(MD) based on optical detection combined with FIA is made in this mini-review. A biosensor system has been designed and realized the real time in vivo monitoring of some important clinic substances such as calcium, uric acid. The system has also been used to study the in vitro binding of drug-protein.

  17. Summary of LHC MD:377: Schottky pick-up

    CERN Document Server

    Betz, Michael; Lefevre, Thibaut; CERN. Geneva. ATS Department

    2015-01-01

    The main objective of this MD was to record Schottky spectra under well known machine conditions. In summary, 7 set-points for the chromaticity and 8 for the emittance have been established and Schottky spectra have been recorded for each setting. The data will be used to benchmark and develop different fitting algorithms. This note presents the initial attempt of curve-fitting and discusses its shortcomings.

  18. Towards automatic coupling corrections with DOROS BPMs (MD750)

    CERN Document Server

    Persson, Tobias Hakan Bjorn; Langner, Andy Sven; Lefevre, Thibaut; Maclean, Ewen Hamish; Malina, Lukas; Olexa, Jakub; Skowronski, Piotr Krzysztof; Garcia-Tabares Valdivieso, Ana; Coello De Portugal - Martinez Vazquez, Jaime Maria; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2015-01-01

    BPMs close to IP1 and IP5 have been equipped with the new DOROS (Diode ORbit OScillation) system which provides precise orbit and turn-by-turn data [1]. In this MD-note we report on the rst measurements with the DOROS system to measure the transverse coupling. Furthermore, we compare the results and the performance of the system to the normal BPMs.

  19. Apple fruit copper amine oxidase isoforms: peroxisomal MdAO1 prefers diamines as substrates, whereas extracellular MdAO2 exclusively utilizes monoamines.

    Science.gov (United States)

    Zarei, Adel; Trobacher, Christopher P; Cooke, Alison R; Meyers, Ashley J; Hall, J Christopher; Shelp, Barry J

    2015-01-01

    4-Aminobutyrate (GABA) accumulates in apple fruit during controlled atmosphere storage. A potential source of GABA is the polyamine putrescine, which can be oxidized via copper-containing amine oxidase (CuAO), resulting in the production 4-aminobutanal/Δ(1)-pyrroline, with the consumption of O2 and release of H2O2 and ammonia. Five putative CuAO genes (MdAO genes) were cloned from apple (Malus domestica Borkh. cv. Empire) fruit, and the deduced amino acid sequences found to contain the active sites typically conserved in CuAOs. Genes encoding two of these enzymes, MdAO1 and MdAO2, were highly expressed in apple fruit and selected for further analysis. Amino acid sequence analysis predicted the presence of a C-terminal peroxisomal targeting signal 1 tripeptide in MdAO1 and an N-terminal signal peptide and N-glycosylation site in MdAO2. Transient expression of green fluorescent fusion proteins in Arabidopsis protoplasts or onion epidermal cells revealed a peroxisomal localization for MdAO1 and an extracellular localization for MdAO2. The enzymatic activities of purified recombinant MdAO1 and MdAO2 were measured continuously as H2O2 production using a coupled reaction. MdAO1 did not use monoamines or polyamines and displayed high catalytic efficiency for 1,3-diaminopropane, putrescine and cadaverine, whereas MdAO2 exclusively utilized aliphatic and aromatic monoamines, including 2-phenylethylamine and tyramine. Together, these results indicate that MdAO1 may contribute to GABA production via putrescine oxidation in the peroxisome of apple fruit under controlled atmosphere conditions. MdAO2 seems to be involved in deamination of 2-phenylethylamine, which is a step in the biosynthesis of 2-phenylethanol, a contributor to fruit flavor and flower fragrance.

  20. The effects of deprivation and relative deprivation on self-reported morbidity in England: an area-level ecological study.

    Science.gov (United States)

    Zhang, Xin; Cook, Penny A; Lisboa, Paulo J; Jarman, Ian H; Bellis, Mark A

    2013-01-29

    Socioeconomic status gradients in health outcomes are well recognised and may operate in part through the psychological effect of observing disparities in affluence. At an area-level, we explored whether the deprivation differential between neighbouring areas influenced self-reported morbidity over and above the known effect of the deprivation of the area itself. Deprivation differentials between small areas (population size approximately 1,500) and their immediate neighbours were derived (from the Index of Multiple Deprivation (IMD)) for Lower Super Output Area (LSOA) in the whole of England (n=32482). Outcome variables were self-reported from the 2001 UK Census: the proportion of the population suffering Limiting Long-Term Illness (LLTI) and 'not good health'. Linear regression was used to identify the effect of the deprivation differential on morbidity in different segments of the population, controlling for the absolute deprivation. The population was segmented using IMD tertiles and P2 People and Places geodemographic classification. P2 is a commercial market segmentation tool, which classifies small areas according to the characteristics of the population. The classifications range in deprivation, with the most affluent type being 'Mature Oaks' and the least being 'Urban Challenge'. Areas that were deprived compared to their immediate neighbours suffered higher rates of 'not good health' (β=0.312, pdeprivation of the area itself ('not good health'-ß=0.655, pdeprivation differential relative to the effect of deprivation was strongest in least deprived segments (e.g., for 'not good health', P2 segments 'Mature Oaks'-β=0.638; 'Rooted Households'-β=0.555). Living in an area that is surrounded by areas of greater affluence has a negative impact on health in England. A possible explanation for this phenomenon is that negative social comparisons between areas cause ill-health. This 'psychosocial effect' is greater still in least deprived segments of the

  1. Happiness, Deprivation and the Alter Ego

    OpenAIRE

    Paolo Verme

    2009-01-01

    The paper focuses on satisfaction with income and proposes a utility model built on two value systems, the `Ego' system - described as one own income assessment relatively to one own past and future income - and the `Alter' system - described as one own income assessment relatively to a reference group. We show how the union of these two value systems and the use of relative deprivation measures can lead to a model able to accommodate a wide range of theories on income and happiness. The mode...

  2. The politics of relative deprivation: A transdisciplinary social justice perspective.

    Science.gov (United States)

    Fu, Mengzhu; Exeter, Daniel J; Anderson, Anneka

    2015-05-01

    Relative deprivation was defined by Townsend (1987, p. 125) as "a state of observable and demonstrable disadvantage, relative to the local community or the wider society or nation to which an individual, family or group belongs". This definition is widely used within social and health sciences to identify, measure, and explain forms of inequality in human societies based on material and social conditions. From a multi-disciplinary social science perspective, we conducted a systematic literature review of published material in English through online database searches and books since 1966. We review the concept and measurement of relative 'deprivation' focussing on area-based deprivation in relation to inequities in health and social outcomes. This paper presents a perspective based in Aotearoa/New Zealand where colonisation has shaped the contours of racialised health inequities and current applications and understandings of 'deprivation'. We provide a critique of Townsend's concept of deprivation and area-based deprivation through a critical, structural analysis and suggest alternatives to give social justice a better chance. Deprivation measures used without critical reflection can lead to deficit framing of populations and maintain current inequities in health and social outcomes. We contend therefore that the lack of consideration of (bio)power, privilege, epistemology and (bio)politics is a central concern in studies of deprivation. Our review highlights the need for the academy to balance the asymmetry between qualitative and quantitative studies of deprivation through trans-disciplinary approaches to understanding deprivation, and subsequently, social and health inequities. We recommend that deprivation research needs be critically applied through a decolonising lens to avoid deficit framing and suggest that there is space for a tool that focuses on measuring the unequal distribution of power and privilege in populations.

  3. Implementation of MD5 Fast Decryption Algorithm Based on Graphic Processing Unit%基于GPU的MD5高速解密算法的实现

    Institute of Scientific and Technical Information of China (English)

    乐德广; 常晋义; 刘祥南; 郭东辉

    2010-01-01

    MD5快速碰撞算法由于不支持逆向过程而无法在MD5密码攻击中得到实际应用.针对上述问题,通过分析基于图形处理单元(GPU)的MD5密码并行攻击算法原理,设计基于GPU的MD5高速解密算法,在此基础上实现一个MD5高速密码攻击系统.测试结果证明,该算法能有效加快MD5密码破解速度.

  4. Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans.

    Science.gov (United States)

    Jung, Christopher M; Melanson, Edward L; Frydendall, Emily J; Perreault, Leigh; Eckel, Robert H; Wright, Kenneth P

    2011-01-01

    Sleep has been proposed to be a physiological adaptation to conserve energy, but little research has examined this proposed function of sleep in humans. We quantified effects of sleep, sleep deprivation and recovery sleep on whole-body total daily energy expenditure (EE) and on EE during the habitual day and nighttime. We also determined effects of sleep stage during baseline and recovery sleep on EE. Seven healthy participants aged 22 ± 5 years (mean ± s.d.) maintained ∼8 h per night sleep schedules for 1 week before the study and consumed a weight-maintenance diet for 3 days prior to and during the laboratory protocol. Following a habituation night, subjects lived in a whole-room indirect calorimeter for 3 days. The first 24 h served as baseline – 16 h wakefulness, 8 h scheduled sleep – and this was followed by 40 h sleep deprivation and 8 h scheduled recovery sleep. Findings show that, compared to baseline, 24 h EE was significantly increased by ∼7% during the first 24 h of sleep deprivation and was significantly decreased by ∼5% during recovery, which included hours awake 25-40 and 8 h recovery sleep. During the night time, EE was significantly increased by ∼32% on the sleep deprivation night and significantly decreased by ∼4% during recovery sleep compared to baseline. Small differences in EE were observed among sleep stages, but wakefulness during the sleep episode was associated with increased energy expenditure. These findings provide support for the hypothesis that sleep conserves energy and that sleep deprivation increases total daily EE in humans.

  5. Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans

    Science.gov (United States)

    Jung, Christopher M; Melanson, Edward L; Frydendall, Emily J; Perreault, Leigh; Eckel, Robert H; Wright, Kenneth P

    2011-01-01

    Sleep has been proposed to be a physiological adaptation to conserve energy, but little research has examined this proposed function of sleep in humans. We quantified effects of sleep, sleep deprivation and recovery sleep on whole-body total daily energy expenditure (EE) and on EE during the habitual day and nighttime. We also determined effects of sleep stage during baseline and recovery sleep on EE. Seven healthy participants aged 22 ± 5 years (mean ± s.d.) maintained ∼8 h per night sleep schedules for 1 week before the study and consumed a weight-maintenance diet for 3 days prior to and during the laboratory protocol. Following a habituation night, subjects lived in a whole-room indirect calorimeter for 3 days. The first 24 h served as baseline – 16 h wakefulness, 8 h scheduled sleep – and this was followed by 40 h sleep deprivation and 8 h scheduled recovery sleep. Findings show that, compared to baseline, 24 h EE was significantly increased by ∼7% during the first 24 h of sleep deprivation and was significantly decreased by ∼5% during recovery, which included hours awake 25–40 and 8 h recovery sleep. During the night time, EE was significantly increased by ∼32% on the sleep deprivation night and significantly decreased by ∼4% during recovery sleep compared to baseline. Small differences in EE were observed among sleep stages, but wakefulness during the sleep episode was associated with increased energy expenditure. These findings provide support for the hypothesis that sleep conserves energy and that sleep deprivation increases total daily EE in humans. PMID:21059762

  6. Application of MD5 Algorithm in Database System%MD5算法在数据库系统中的应用

    Institute of Scientific and Technical Information of China (English)

    罗金涛

    2013-01-01

    数据加密是保护数据安全的重要手段,MD5是目前信息安全领域中使用比较广泛的加密算法,对MD5算法的原理进行了分析,并将MD5算法应用在数据库的登录验证过程中.

  7. Immunization against mucosal disease--bovine viral Diarrhea (MD-BVD) in calves applying lapinized vaccine against swine fever and a modified live virus of MD-BVD.

    Science.gov (United States)

    Haralambiev, H; Tsvetkov, P; Nikolov, A; Gaytandgieva, R

    1975-01-01

    Calves vaccinated with the modified strain C24V react by creating neutralizing antibodies in high titres and are resistent to infection while non-immunized calves manifest the clinical symptoms of MD-BVD. Calves, vaccinated with the lapinized strain "K" of the SF virus react by creating neutralizing antibodies in low titres against the vius of MD-BVD and manifest no apparent clinical symptoms after challenge with the virulent strain MD-BVD.

  8. 76 FR 20034 - Calvin Ramsey, M.D.; Revocation of Registration

    Science.gov (United States)

    2011-04-11

    ... Enforcement Administration Calvin Ramsey, M.D.; Revocation of Registration On December 18, 2009, the Deputy... Show Cause to Calvin Ramsey, M.D. (Respondent), of Millington, Tennessee. The Show Cause Order proposed..., I order that DEA Certificate of Registration, AR7086689, issued to Calvin Ramsey, M.D., be, and...

  9. 76 FR 48884 - Stacey J. Webb, M.D.; Denial of Application

    Science.gov (United States)

    2011-08-09

    .... DEA, 2008 WL 4899525 (6th Cir. 2008). ``Moreover, because `past performance is the best predictor of.... Stodola, M.D., 74 FR 20727 (2009); Dale L. Taylor, M.D., 72 FR 30855 (2007); Andre DeSonia, M.D., 72 FR...

  10. 75 FR 32866 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Science.gov (United States)

    2010-06-10

    ... River, Solomons, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast... races, a marine event to be held on the waters of the Patuxent River, near Solomons, MD on October 3... Patuxent River near Solomons, MD. The event consists of offshore power boats racing in a counter-clockwise...

  11. 76 FR 52865 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Science.gov (United States)

    2011-08-24

    ... River, Solomons, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is... be held on the waters of the Patuxent River, near Solomons, MD on September 24 and 25, 2011. These... Marine Events; Patuxent River, Solomons, MD'' in the Federal Register (76 FR 118). We received no...

  12. 76 FR 35802 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Science.gov (United States)

    2011-06-20

    .... USCG-2011-0266] RIN 1625-AA08 Special Local Regulations for Marine Events; Patuxent River, Solomons, MD... be held on the waters of the Patuxent River, near Solomons, MD on September 24 and 25, 2011. These... boat races on the Patuxent River near Solomons, MD. The event consists of offshore power boats racing...

  13. 77 FR 47279 - Special Local Regulations for Marine Events, Patuxent River; Solomons, MD

    Science.gov (United States)

    2012-08-08

    ... River; Solomons, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is... be held on the waters of the Patuxent River, near Solomons, MD on September 15 and 16, 2012. These..., Solomons, MD'' in the Federal Register (77 FR 25649). We received no comments on the proposed rule. No...

  14. 75 FR 57388 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Science.gov (United States)

    2010-09-21

    ... River, Solomons, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is... be held on the waters of the Patuxent River, near Solomons, MD on October 1, 2010 and October 3, 2010... Marine Events; Patuxent River, Solomons, MD'' in the Federal Register (75 FR 32866). Additionally, on...

  15. The Application Research of MD5 Encryption Algorithm in DCT Digital Watermarking

    Science.gov (United States)

    Xijin, Wang; Linxiu, Fan

    This article did the preliminary study of the application of algorithm for MD5 in the digital watermark. It proposed that copyright information will be encrypted using an algorithm MD5, and made rules for the second value image watermarks, through DCT algorithm that embeds an image by the carrier. The extraction algorithms can pick up the watermark and restore MD5 code.

  16. Crystal structure of soluble MD-1 and its interaction with lipid IVa

    Science.gov (United States)

    Yoon, Sung-il; Hong, Minsun; Han, Gye Won; Wilson, Ian A.

    2010-01-01

    Lipopolysaccharide (LPS) of Gram-negative bacteria is a common pathogen-associated molecular pattern (PAMP) that induces potent innate immune responses. The host immune response against LPS is triggered by myeloid differentiation factor 2 (MD-2) in association with Toll-like receptor 4 (TLR4) on the cell surface. The MD-2/TLR4-mediated LPS response is regulated by the evolutionarily related complex of MD-1 and Toll-like receptor homolog RP105. Here, we report crystallographic and biophysical data that demonstrate a previously unidentified direct interaction of MD-1 with LPS. The crystal structure of chicken MD-1 (cMD-1) at 2.0 Å resolution exhibits a β-cup-like fold, similar to MD-2, that encloses a hydrophobic cavity between the two β-sheets. A lipid-like moiety was observed inside the cavity, suggesting the possibility of a direct MD-1/LPS interaction. LPS was subsequently identified as an MD-1 ligand by native gel electrophoresis and gel filtration analyses. The crystal structure of cMD-1 with lipid IVa, an LPS precursor, at 2.4 Å resolution revealed that the lipid inserts into the deep hydrophobic cavity of the β-cup-like structure, but with some important differences compared with MD-2. These findings suggest that soluble MD-1 alone, in addition to its complex with RP105, can regulate host LPS sensitivity. PMID:20534476

  17. O impacto da visão monocular congênita versus adquirida na qualidade de visão autorrelatada

    Directory of Open Access Journals (Sweden)

    Marcelo Caram Ribeiro Fernandes

    2010-12-01

    Full Text Available Objetivos: Quando a visão de um olho está preservada (visão monocular e há alto risco, baixo prognóstico e/ou recursos limitados para a cirurgia do olho contralateral, não é claro se o beneficio da binocularidade supera o da reorientação para visão monocular. O objetivo é quantificar o impacto da qualidade de visão referida entre a condição binocular e monocular e, nesse último caso, entre congênita e adquirida. Métodos: Pacientes com acuidade visual (AV com AV>0,5 em cada olho foram submetidos ao questionário estruturado de 14 perguntas (VF-14, onde a pontuação de 0 a 100 indica o nível de satisfação do paciente com sua visão, variando de baixo a alto respectivamente. Dados epidemiológicos e pontuações dos quatro grupos foram registrados e submetidos à análise estatística. Resultados: A entrevista pelo VF-14 com 56 indivíduos revelou que a pontuação mais alta foi similar entre os controles e os portadores de visão monocular congênita, e níveis intermediários e baixos foram obtidos por indivíduos com visão monocular adquirida e cegos bilaterais, respectivamente (p<0,001. As atividades mais difíceis para os indivíduos com visão monocular adquirida foram identificar letras pequenas, reconhecer pessoas, distinguir sinais de trânsito e assistir TV. Conclusão: O estudo confirmou que a perda da visão tem impacto desfavorável no desempenho referido das atividades sendo maior na visão monocular adquirida do que na congênita. Os dados sugerem que medidas de reabilitação devem ser consideradas para melhorar a qualidade da visão em doenças intratáveis ou de alto risco ou de baixo prognóstico.

  18. Social comparison, personal relative deprivation, and materialism.

    Science.gov (United States)

    Kim, Hyunji; Callan, Mitchell J; Gheorghiu, Ana I; Matthews, William J

    2017-06-01

    Across five studies, we found consistent evidence for the idea that personal relative deprivation (PRD), which refers to resentment stemming from the belief that one is deprived of deserved outcomes compared to others, uniquely contributes to materialism. In Study 1, self-reports of PRD positively predicted materialistic values over and above socioeconomic status, personal power, self-esteem, and emotional uncertainty. The experience of PRD starts with social comparison, and Studies 2 and 3 found that PRD mediated the positive relation between a tendency to make social comparisons of abilities and materialism. In Study 4, participants who learned that they had less (vs. similar) discretionary income than people like them reported a stronger desire for more money relative to donating more to charity. In Study 5, during a windfall-spending task, participants higher in PRD spent more on things they wanted relative to other spending categories (e.g., paying off debts). © 2016 The Authors. British Journal of Social Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.

  19. BDNF in sleep, insomnia, and sleep deprivation.

    Science.gov (United States)

    Schmitt, Karen; Holsboer-Trachsler, Edith; Eckert, Anne

    2016-01-01

    The protein brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors involved in plasticity of neurons in several brain regions. There are numerous evidence that BDNF expression is decreased by experiencing psychological stress and that, accordingly, a lack of neurotrophic support causes major depression. Furthermore, disruption in sleep homeostatic processes results in higher stress vulnerability and is often associated with stress-related mental disorders. Recently, we reported, for the first time, a relationship between BDNF and insomnia and sleep deprivation (SD). Using a biphasic stress model as explanation approach, we discuss here the hypothesis that chronic stress might induce a deregulation of the hypothalamic-pituitary-adrenal system. In the long-term it leads to sleep disturbance and depression as well as decreased BDNF levels, whereas acute stress like SD can be used as therapeutic intervention in some insomniac or depressed patients as compensatory process to normalize BDNF levels. Indeed, partial SD (PSD) induced a fast increase in BDNF serum levels within hours after PSD which is similar to effects seen after ketamine infusion, another fast-acting antidepressant intervention, while traditional antidepressants are characterized by a major delay until treatment response as well as delayed BDNF level increase. Key messages Brain-derived neurotrophic factor (BDNF) plays a key role in the pathophysiology of stress-related mood disorders. The interplay of stress and sleep impacts on BDNF level. Partial sleep deprivation (PSD) shows a fast action on BDNF level increase.

  20. MD5算法在用户口令认证中的应用%The Application of MD5 Algorithm in The User Password Authentication

    Institute of Scientific and Technical Information of China (English)

    刘洪民; 印帮辉

    2014-01-01

    MD5算法是目前比较安全且易用的加密算法,其在密码领域有着举足轻重的地位.本文通过介绍MD5算法的特点及加密原理,分析了MD5算法在用户口令认证中的安全隐患,给出了用户口令认证应用中如何提高MD5算法安全性的措施和方法.

  1. Application of MD5 Encryption Algorithm Based on C# Technology%基于C#技术的MD5加密算法的应用

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    在对Message-Digest Algorithm 5进行简要描述的同时,对MD5算法的原理作深入分析.运用MD5算法,采用目前流行的C#语言进行了具体研究,设计了MD5加密演示系统,经过测试该系统可以准确实现数据的MD5加密.

  2. SECURITY ANALYSIS ON MD5 AND ITS APPLICATION%MD5安全性分析及其应用

    Institute of Scientific and Technical Information of China (English)

    谭剑鸣; 徐建华; 汪崇华

    2002-01-01

    本文详细论述了MD5报文分解函数对文件签名的工作原理,剖析了MD5的安全性,针对具体的应用提出了使用MD5与RSA结合来解决数字签名的完整方案.文章的最后对MD5在PGP数字签名中的具体应用进行了分析讨论.

  3. Design and Implementation of MD5 with Salt%一种带随机数MD5算法的设计与实现

    Institute of Scientific and Technical Information of China (English)

    张丽香

    2013-01-01

    随着网络的迅速普及,信息加密技术的发展对保障网络安全有着重大的作用与意义.MD5是HASH算法,常用来对重要数据的进行存储,本文对MD5算法进行了简要描述,介绍了MD5的破解方式,并对带随机数MD5算法进行了描述,采用PHP对算法的使用进行实现.

  4. Sex-dependent changes in brain CB1R expression and functionality and immune CB2R expression as a consequence of maternal deprivation and adolescent cocaine exposure.

    Science.gov (United States)

    Llorente-Berzal, Alvaro; Assis, María A; Rubino, Tiziana; Zamberletti, Erica; Marco, Eva M; Parolaro, Daniela; Ambrosio, Emilio; Viveros, María-Paz

    2013-08-01

    Early life stress has been associated with several psychiatric disorders, including drug addiction. Actually, maternal deprivation (MD) alters the endocannabinoid system, which participates in motivation and reward for drugs, including cocaine. At youth, the rate of cocaine abuse is alarmingly increasing. Herein, we have investigated the consequences of MD and/or adolescent cocaine exposure in brain CB1Rs and CB2Rs in immune tissues. Control and maternally deprived (24h on postnatal day, pnd, 9) male and female Wistar rats were administered cocaine (8mg/kg/day) or saline during adolescence (pnd 28-42). At adulthood, [(3)H]-CP-55,940 autoradiographic binding was employed for the analysis of CB1R density and CP-55,940-stimulated [(35)S]-GTPgammaS binding for CB1R functionality; CB2R expression was analyzed by Western blotting. Sex differences in CB1R expression and functionality were found, and MD induced important and enduring sex-dependent changes. In addition, the plastic changes induced by adolescent cocaine administration in brain CB1Rs were differentially influenced by early life events. MD increased spleen CB2R expression while adolescent cocaine administration attenuated this effect; cocaine exposure also diminished CB2R expression in bone marrow. Present findings provide evidence for changes in brain CB1R expression and functionality and immune CB2R expression as a consequence of early life stress and adolescent cocaine exposure, and indicate functional interactions between both treatments, which in many regions differ between males and females.

  5. The impact of area deprivation on parenting stress

    NARCIS (Netherlands)

    Spijkers, Willem; Jansen, Danielle E. M. C.; Reijneveld, Sijmen A.

    2012-01-01

    Background: Area deprivation negatively affects health and lifestyles, among which child behaviours. The latter may aggravate the effects of area deprivation on parental health due to higher rates of parenting stress. However, evidence on the influence of the living environment on parenting stress i

  6. Violent Crime, Sociopathy and Love Deprivation among Adolescent Delinquents.

    Science.gov (United States)

    Walsh, Anthony; Beyer, J. Arthur

    1987-01-01

    Examined relationships between performance-verbal (P-V) discrepancy scores on Wechsler Intelligence Quotient Scales, love deprivation, and juvenile delinquency among 131 male juvenile probationers. P-V discrepancy scores were significantly related to love deprivation and violent crimes, supporting assertion that early emotional stresses affect…

  7. The Determinants of Deprivation in Jordan: Empirical Study

    Directory of Open Access Journals (Sweden)

    Mohammed I. Shahateet

    2007-01-01

    Full Text Available The objective of this study was to determine and explain the factors that affect deprivation in Jordan. To do so, this study constructs and tests a model that determines the factors, which affect deprivation. It employs an econometric analysis to examine the relationship between some main socioeconomic variables and the status of deprivation in Jordan. It looks at how changes in income, unemployment, education, health, housing conditions and access to services, as well as pollution, will affect the status of deprivation. The study uses the raw data of the national Household Income and Expenditure Survey HIES, which was conducted by the Jordanian Department of Statistics during 2002/2003 and covered 12,792 households. The study concludes that deprivation was caused by low income, unemployment, low educational attainment, bad type of housing, barriers to essential services, poor health and pollution. However, the effect of these factors varies. Simulation results of the model predicts that if income deprivation, unemployment and education deprivation are reduced by 1% the overall deprivation index will decrease by 0.7%, holding other variables without change. Realizing such reductions, however, will require policies to further increase wages and salaries, encourage investment in human capital and job creation.

  8. Sleep deprivation and spike-wave discharges in epileptic rats

    NARCIS (Netherlands)

    Drinkenburg, W.H.I.M.; Coenen, A.M.L.; Vossen, J.M.H.; Luijtelaar, E.L.J.M. van

    1995-01-01

    The effects of sleep deprivation were studied on the occurrence of spike-wave discharges in the electroencephalogram of rats of the epileptic WAG/Rij strain, a model for absence epilepsy. This was done before, during and after a period of 12 hours of near total sleep deprivation. A substantial incre

  9. The impact of area deprivation on parenting stress

    NARCIS (Netherlands)

    Spijkers, Willem; Jansen, Danielle E. M. C.; Reijneveld, Sijmen A.

    2012-01-01

    Background: Area deprivation negatively affects health and lifestyles, among which child behaviours. The latter may aggravate the effects of area deprivation on parental health due to higher rates of parenting stress. However, evidence on the influence of the living environment on parenting stress

  10. Relative Deprivation and Adolescent Outcomes in Iceland: A Multilevel Test

    Science.gov (United States)

    Bernburg, Jon Gunnar; Thorlindsson, Thorolfur; Sigfusdottir, Inga Dora

    2009-01-01

    The theory of relative deprivation emphasizes that social comparisons contextualize how people experience impoverishment. An important application of this theory argues that relative deprivation that stems from unfavorable social comparisons can result in anger, normlessness and an increased likelihood of deviant behavior. We test this theory in a…

  11. Are seizures in the setting of sleep deprivation provoked?

    Science.gov (United States)

    Lawn, Nicholas; Lieblich, Sam; Lee, Judy; Dunne, John

    2014-04-01

    It is generally accepted that sleep deprivation contributes to seizures. However, it is unclear whether a seizure occurring in the setting of sleep deprivation should be considered as provoked or not and whether this is influenced by seizure type and etiology. This information may have an important impact on epilepsy diagnosis and management. We prospectively analyzed the influence of sleep deprivation on the risk of seizure recurrence in patients with first-ever unprovoked seizures and compared the findings with patients with first-ever provoked seizures. Of 1026 patients with first-ever unprovoked seizures, 204 (20%) were associated with sleep deprivation. While the overall likelihood of seizure recurrence was slightly lower in sleep-deprived patients with first-ever seizures (log-rank p=0.03), sleep deprivation was not an independent predictor of seizure recurrence on multivariate analysis. Seizure recurrence following a first-ever unprovoked seizure associated with sleep deprivation was far more likely than for 174 patients with a provoked first-ever seizure (log-rank psleep deprivation should not be regarded as provoked. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. Sleep deprivation and spike-wave discharges in epileptic rats

    NARCIS (Netherlands)

    Drinkenburg, W.H.I.M.; Coenen, A.M.L.; Vossen, J.M.H.; Luijtelaar, E.L.J.M. van

    1995-01-01

    The effects of sleep deprivation were studied on the occurrence of spike-wave discharges in the electroencephalogram of rats of the epileptic WAG/Rij strain, a model for absence epilepsy. This was done before, during and after a period of 12 hours of near total sleep deprivation. A substantial

  13. Sleep Deprivation, Allergy Symptoms, and Negatively Reinforced Problem Behavior.

    Science.gov (United States)

    Kennedy, Craig H.; Meyer, Kim A.

    1996-01-01

    A study of the relationship between presence or absence of sleep deprivation, allergy symptoms, and the rate and function of problem behavior in three adolescents with moderate to profound mental retardation found that problem behavior was negatively reinforced by escape from instruction, and both allergy symptoms and sleep deprivation influenced…

  14. A new model to study sleep deprivation-induced seizure.

    Science.gov (United States)

    Lucey, Brendan P; Leahy, Averi; Rosas, Regine; Shaw, Paul J

    2015-05-01

    A relationship between sleep and seizures is well-described in both humans and rodent animal models; however, the mechanism underlying this relationship is unknown. Using Drosophila melanogaster mutants with seizure phenotypes, we demonstrate that seizure activity can be modified by sleep deprivation. Seizure activity was evaluated in an adult bang-sensitive seizure mutant, stress sensitive B (sesB(9ed4)), and in an adult temperature sensitive seizure mutant seizure (sei(ts1)) under baseline and following 12 h of sleep deprivation. The long-term effect of sleep deprivation on young, immature sesB(9ed4) flies was also assessed. Laboratory. Drosophila melanogaster. Sleep deprivation. Sleep deprivation increased seizure susceptibility in adult sesB(9ed4)/+ and sei(ts1) mutant flies. Sleep deprivation also increased seizure susceptibility when sesB was disrupted using RNAi. The effect of sleep deprivation on seizure activity was reduced when sesB(9ed4)/+ flies were given the anti-seizure drug, valproic acid. In contrast to adult flies, sleep deprivation during early fly development resulted in chronic seizure susceptibility when sesB(9ed4)/+ became adults. These findings show that Drosophila is a model organism for investigating the relationship between sleep and seizure activity. © 2015 Associated Professional Sleep Societies, LLC.

  15. Sleep deprivation in pigeons and rats using motion detection.

    Science.gov (United States)

    Newman, Sarah M; Paletz, Elliott M; Obermeyer, William H; Benca, Ruth M

    2009-10-01

    Forced sleep deprivation results in substantial behavioral and physiologic effects in mammals. The disk-over-water (DOW) method produces a syndrome characterized by increased energy expenditure and a robust preferentially rapid-eye-movement sleep rebound upon recovery or eventual death after several weeks of sleep deprivation. The DOW has been used successfully only in rats. This paper presents a method to enforce long-term controlled sleep deprivation across species and to compare its effects in rats and pigeons. A conveyor was substituted for the DOW disk. Behavior rather than electroencephalography was used to trigger arousal stimuli, as in gentle-handling deprivation. Rats and pigeons were deprived using this apparatus, and the results were compared with each other and with published reports. The physiologic consequences and recovery sleep in rats were like those published for DOW rats. Magnitude of sleep loss and recovery patterns in pigeons were similar to those seen in rats, but expected symptoms of the sleep deprivation syndrome were absent in pigeons. The use of a motion trigger allowed us to measure and, thus, to assess the quality and impact of the procedure. Prolonged and controlled sleep deprivation can be enforced using automated motion detection and a conveyor-over-water system. Pigeons and rats, deprived of sleep to the same extent, showed similar patterns of recovery sleep, but pigeons did not exhibit the hyperphagia, weight loss, and debilitation seen in rats.

  16. The impact of area deprivation on parenting stress

    NARCIS (Netherlands)

    Spijkers, Willem; Jansen, Danielle E. M. C.; Reijneveld, Sijmen A.

    2012-01-01

    Background: Area deprivation negatively affects health and lifestyles, among which child behaviours. The latter may aggravate the effects of area deprivation on parental health due to higher rates of parenting stress. However, evidence on the influence of the living environment on parenting stress i

  17. Sleep Deprivation, Allergy Symptoms, and Negatively Reinforced Problem Behavior.

    Science.gov (United States)

    Kennedy, Craig H.; Meyer, Kim A.

    1996-01-01

    A study of the relationship between presence or absence of sleep deprivation, allergy symptoms, and the rate and function of problem behavior in three adolescents with moderate to profound mental retardation found that problem behavior was negatively reinforced by escape from instruction, and both allergy symptoms and sleep deprivation influenced…

  18. Deprivation and Deservingness: Distributive Justice at Home and at Work.

    Science.gov (United States)

    Crosby, Faye

    An exploration of interpersonal justice suggests some connections among relative deprivation theory, justice theory, and depression research. Distinctions between home life and work life are necessary in thinking about fairness, deservingness, and deprivation. A survey of over 400 adults explored the extent to which men and women feel deprived…

  19. Relative Deprivation and Perception of Financial Adequacy among the Aged.

    Science.gov (United States)

    Liang, Jersey; Fairchild, Thomas J.

    1979-01-01

    Presents a conceptual framework that incorporates the notion of relative deprivation to explain the perceived financial adequacy among the elderly. Financial satisfaction is directly related to relative deprivation while income only indirectly affects one's sense of financial well-being. (Author)

  20. Contingent Employment in Academic Careers: Relative Deprivation among Adjunct Faculty

    Science.gov (United States)

    Feldman, Daniel C.; Turnley, William H.

    2004-01-01

    This article utilizes relative deprivation theory to examine the careers of non-tenure-track instructors and research associates. Demographic status, motivations for accepting contingent employment, and standards of comparison used to assess the quality of the job were all related to the degree of relative deprivation experienced by adjunct…

  1. Minding the gap: Subjective relative deprivation and depressive symptoms.

    Science.gov (United States)

    Beshai, Shadi; Mishra, Sandeep; Meadows, Tyler J S; Parmar, Priya; Huang, Vivian

    2017-01-01

    Substantial evidence has linked depressive symptoms to various indices of societal-level inequality and relative deprivation. A larger literature has also addressed cognitive vulnerability and correlates of depression. Despite this evidence, little research to date has examined the relationship of depressive symptoms with such downstream individual-level consequences of inequality as subjective relative deprivation, or whether relative deprivation is associated with cognitive vulnerability in depression. We conducted two investigations among four separate samples (total N = 2999) to examine associations between subjective relative deprivation and depressive symptoms and cognitions. Across our studies and four different self-report measures of depressive symptoms, we found consistent significant positive associations between subjective relative deprivation and depression symptoms. Further, we found that subjective relative deprivation was predictive of depressive symptoms over and above other known vulnerability factors. Finally, we found that the relationship between subjective relative deprivation and depressive symptoms was fully mediated by negative automatic thoughts about self. These results provide further evidence of the importance of subjective deprivation in maintaining negative mental health outcomes. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Relative Deprivation and Adolescent Outcomes in Iceland: A Multilevel Test

    Science.gov (United States)

    Bernburg, Jon Gunnar; Thorlindsson, Thorolfur; Sigfusdottir, Inga Dora

    2009-01-01

    The theory of relative deprivation emphasizes that social comparisons contextualize how people experience impoverishment. An important application of this theory argues that relative deprivation that stems from unfavorable social comparisons can result in anger, normlessness and an increased likelihood of deviant behavior. We test this theory in a…

  3. Tempol prevents chronic sleep-deprivation induced memory impairment.

    Science.gov (United States)

    Alzoubi, Karem H; Khabour, Omar F; Albawaana, Amal S; Alhashimi, Farah H; Athamneh, Rabaa Y

    2016-01-01

    Sleep deprivation is associated with oxidative stress that causes learning and memory impairment. Tempol is a nitroxide compound that promotes the metabolism of many reactive oxygen species (ROS) and has antioxidant and neuroprotective effect. The current study investigated whether chronic administration of tempol can overcome oxidative stress and prevent learning and memory impairment induced by sleep deprivation. Sleep deprivation was induced in rats using multiple platform model. Tempol was administered to rats via oral gavages. Behavioral studies were conducted to test the spatial learning and memory using radial arm water maze. The hippocampus was dissected; antioxidant biomarkers (GSH, GSSG, GSH/GSSG ratio, GPx, SOD, and catalase) were assessed. The result of this project revealed that chronic sleep deprivation impaired both short and long term memory (Psleep deprivation induced reduction in the hippocampus activity of catalase, GPx, and SOD (Psleep deprived rats treated with tempol as compared with only sleep deprived rats (Psleep deprivation induced memory impairment, and treatment with tempol prevented this impairment probably through normalizing antioxidant mechanisms in the hippocampus.

  4. Effects of Sleep Deprivation on Dissociated Components of Executive Functioning

    Science.gov (United States)

    Tucker, Adrienne M.; Whitney, Paul; Belenky, Gregory; Hinson, John M.; Van Dongen, Hans P.A.

    2010-01-01

    Study Objectives: We studied the effects of sleep deprivation on executive functions using a task battery which included a modified Sternberg task, a probed recall task, and a phonemic verbal fluency task. These tasks were selected because they allow dissociation of some important executive processes from non-executive components of cognition. Design: Subjects were randomized to a total sleep deprivation condition or a control condition. Performance on the executive functions task battery was assessed at baseline, after 51 h of total sleep deprivation (or no sleep deprivation in the control group), and following 2 nights of recovery sleep, at fixed time of day (11:00). Performance was also measured repeatedly throughout the experiment on a control task battery, for which the effects of total sleep deprivation had been documented in previously published studies. Setting: Six consecutive days and nights in a controlled laboratory environment with continuous behavioral monitoring. Participants: Twenty-three healthy adults (age range 22–38 y; 11 women). Twelve subjects were randomized to the sleep deprivation condition; the others were controls. Results: Performance on the control task battery was considerably degraded during sleep deprivation. Overall performance on the modified Sternberg task also showed impairment during sleep deprivation, as compared to baseline and recovery and compared to controls. However, two dissociated components of executive functioning on this task—working memory scanning efficiency and resistance to proactive interference—were maintained at levels equivalent to baseline. On the probed recall task, resistance to proactive interference was also preserved. Executive aspects of performance on the phonemic verbal fluency task showed improvement during sleep deprivation, as did overall performance on this task. Conclusion: Sleep deprivation affected distinct components of cognitive processing differentially. Dissociated non

  5. Binocularity in the little owl, Athene noctua. II. Properties of visually evoked potentials from the Wulst in response to monocular and binocular stimulation with sine wave gratings.

    Science.gov (United States)

    Porciatti, V; Fontanesi, G; Raffaelli, A; Bagnoli, P

    1990-01-01

    Visually evoked potentials (VEPs) have been recorded from the Wulst surface of the little owl, Athene noctua, in response to counterphase-reversal of sinusoidal gratings with different contrast, spatial frequency and mean luminance, presented either monocularly or binocularly. Monocular full-field stimuli presented to either eye evoked VEPs of similar amplitude, waveform and latency. Under binocular viewing, VEPs approximately doubled in amplitude without waveform changes. VEPs with similar characteristics could be obtained in response to stimulation of the contralateral, but not ipsilateral, hemifield. These results suggest that a 50% recrossing occurs in thalamic efferents and that different ipsilateral and contralateral regions converge onto the same Wulst sites. The VEP amplitude progressively decreased with increase of the spatial frequency beyond 2 cycles/degree, and the high spatial frequency cut-off (VEP acuity) was under binocular viewing (8 cycles/degree) higher than under monocular (5 cycles/degree) viewing (200 cd/m2, 45% contrast). The VEP acuity increased with increase in the contrast and decreased with reduction of the mean luminance. The binocular gain in both VEP amplitude and VEP acuity was largest at the lowest luminance levels. Binocular VEP summation occurred in the medium-high contrast range. With decreased contrast, both monocular and binocular VEPs progressively decreased in amplitude and tended to the same contrast threshold. The VEP contrast threshold depended on the spatial frequency (0.6-1.8% in the range 0.12-2 cycles/degree). Binocular VEPs often showed facilitatory interaction (binocular/monocular amplitude ratio greater than 2), but the binocular VEP amplitude did not change either by changing the stimulus orientation (horizontal vs. vertical gratings) or by inducing different retinal disparities.(ABSTRACT TRUNCATED AT 250 WORDS)

  6. The prospective association between sleep deprivation and depression among adolescents.

    Science.gov (United States)

    Roberts, Robert E; Duong, Hao T

    2014-02-01

    To examine the prospective, reciprocal association between sleep deprivation and depression among adolescents. A community-based two-wave cohort study. A metropolitan area with a population of over 4 million. 4,175 youths 11-17 at baseline, and 3,134 of these followed up a year later. Depression is measured using both symptoms of depression and DSM-IV major depression. Sleep deprivation is defined as ≤ 6 h of sleep per night. Sleep deprivation at baseline predicted both measures of depression at follow-up, controlling for depression at baseline. Examining the reciprocal association, major depression at baseline, but not symptoms predicted sleep deprivation at follow-up. These results are the first to document reciprocal effects for major depression and sleep deprivation among adolescents using prospective data. The data suggest reduced quantity of sleep increases risk for major depression, which in turn increases risk for decreased sleep.

  7. Sex-dependent effects of early maternal deprivation on MDMA-induced conditioned place preference in adolescent rats: possible neurochemical correlates.

    Science.gov (United States)

    Llorente-Berzal, Alvaro; Manzanedo, Carmen; Daza-Losada, Manuel; Valero, Manuel; López-Gallardo, Meritxell; Aguilar, María A; Rodríguez-Arias, Marta; Miñarro, José; Viveros, Maria-Paz

    2013-09-01

    The early neonatal stage constitutes a sensitive period during which exposure to adverse events can increase the risk of neuropsychiatric disorders. Maternal deprivation (MD) is a model of early life stress that induces long-term behavioural and physiological alterations, including susceptibility to different drugs of abuse. In the present study we have used the conditioned place preference (CPP) paradigm to address the influence of MD on the rewarding effects of 3,4-methylenedioxymetamphetamine (MDMA) in adolescent animals of both sexes. We have previously observed in adolescent rats that MD induces modifications in the serotonergic and endocannabinoid systems, which play a role in the rewarding effects of MDMA. In light of this evidence, we hypothesized that MD would alter the psychobiological consequences of exposure to MDMA. Neonatal Wistar rats underwent MD (24h, on PND 9) or were left undisturbed (controls). The animals were conditioned with 2.5mg/kg MDMA during the periadolescent period (PND 34-PND 43) and were tested in the open-field test at the end of adolescence (PND 60). Animals were sacrificed on PND 68-75 and levels of serotonin (5-HT) and its metabolite 5-hydroxyindole acetic acid were measured in the striatum, hippocampus and cortex, while the expression of hippocampal CB1 cannabinoid receptor (CB1R) and circulating levels of corticosterone and leptin were also measured. Control males showed CPP after administration of MDMA. However, no MDMA-induced CPP was detected in control females or MD males, and MD had no effect on open field activity in any group. A reduction in striatal and cortical 5-HT levels, increased expression of hippocampal CB1R and a marked trend towards higher circulating leptin levels were observed in MDMA-treated MD males. Our results demonstrate for the first time that MD reduces the rewarding effects of MDMA in a sex-dependent manner. We propose that this effect is related, at least in part, with alterations of the serotonergic

  8. StandsSIM-MD: a Management Driven forest SIMulator

    Energy Technology Data Exchange (ETDEWEB)

    Barreiro, S.; Rua, J.; Tomé, M.

    2016-07-01

    Aim of the study. The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy. The objective was developing one easily-updatable, user-friendly, forest management and climate change sensitive simulator capable of projecting growth for the main tree species in Portugal. Area of the study: Portugal. Material and methods: The new simulator was programmed in a modular form consisting of several modules. The growth module integrates different forest growth and yield models (empirical and process-based) for the main wood production tree species in Portugal (eucalypt, umbrella and maritime pines); whereas the management module drives the growth projections along the planning horizon according to a range of forest management approaches and climate (at present only available for eucalypt). Main results: The main result is the StandsSIM-MD Management Driven simulator that overcomes the limitations of the existing stand level simulators. It is a step forward when compared to the models currently available in the sIMfLOR platform covering more tree species, stand structures and stand compositions. It is focused on end-users and it is based on similar concepts regarding the generation of required inputs and generated outputs. Research highlights: Forest Management Driven simulations approach. Multiple Prescriptions-Per-Stand functionality. StandsSIM-MD can be used to support landowners decisions on stand forest management. StandsSIM-MD simulations at regional level can be combined with optimization routines. (Author)

  9. StandsSIM-MD: a Management Driven forest SIMulator

    Directory of Open Access Journals (Sweden)

    Susana Barreiro

    2016-07-01

    Full Text Available Aim of the study: The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy. The objective was developing one easily-updatable, user-friendly, forest management and climate change sensitive simulator capable of projecting growth for the main tree species in Portugal. Area of the study: Portugal. Material and methods: The new simulator was programmed in a modular form consisting of several modules. The growth module integrates different forest growth and yield models (empirical and process-based for the main wood production tree species in Portugal (eucalypt, umbrella and maritime pines; whereas the management module drives the growth projections along the planning horizon according to a range of forest management approaches and climate (at present only available for eucalypt. Main results: The main result is the StandsSIM-MD Management Driven simulator that overcomes the limitations of the existing stand level simulators. It is a step forward when compared to the models currently available in the sIMfLOR platform covering more tree species, stand structures and stand compositions. It is focused on end-users and it is based on similar concepts regarding the generation of required inputs and generated outputs. Research highlights: -          Forest Management Driven simulations approach -          Multiple Prescriptions-Per-Stand functionality -          StandsSIM-MD can be used to support landowners decisions on stand forest management -          StandsSIM-MD simulations at regional level can be combined with optimization routines Keywords: Forest simulator, Forest Management Approaches; StandsSIM-MD; forest management.

  10. A Secure Hash Function MD-192 With Modified Message Expansion

    CERN Document Server

    Tiwari, Harshvardhan

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which generates more bit difference in each working variable to make the algorithm more secure. This hash function is collision resistant and assures a good compression and preimage resistance.

  11. Nano-scratch study of molecular deposition (MD) films on silicon wafer using nanoindentation~1

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Experiment of the molecular deposition (MD) films with and without alkyl terminal de-posited on the silicon wafer were conducted by using nanoindentation. It was found that MD filmsand alkyl terminated MD films exhibit higher critical load (scratch resistance or adhesive strength)and lower coefficient of friction compared with the silicon substrate. Critical load (scratch resis-tance) increases with the number of layers, and coefficients of friction of those MD film with alkylterminal are still best for the same layer of MD film.

  12. 改进MD5码增强网站密码安全性

    Institute of Scientific and Technical Information of China (English)

    张越; 陈跃; 刘林飞

    2009-01-01

    目的探讨改进MD5码,增强网络安全性.方法采用对用户密码进行加长、加强的二次加密,并对MD5码的算法进行修改,再使用MD5二次加密或多次加密.结果通过改进MD5码,用户密码安全性明显增强.结论改进MD5码,可以提高网站安全性.

  13. Sleep deprived and sweating it out: the effects of total sleep deprivation on skin conductance reactivity to psychosocial stress.

    Science.gov (United States)

    Liu, Jean C J; Verhulst, Silvan; Massar, Stijn A A; Chee, Michael W L

    2015-01-01

    We examined how sleep deprivation alters physiological responses to psychosocial stress by evaluating changes in skin conductance. Between-subjects design with one group allocated to 24 h of total sleep deprivation and the other to rested wakefulness. The study took place in a research laboratory. Participants were 40 healthy young adults recruited from a university. Sleep deprivation and feedback. Electrodermal activity was monitored while participants completed a difficult perceptual task with false feedback. All participants showed increased skin conductance levels following stress. However, compared to well-rested participants, sleep deprived participants showed higher skin conductance reactivity with increasing stress levels. Our results suggest that sleep deprivation augments allostatic responses to increasing psychosocial stress. Consequentially, we propose sleep loss as a risk factor that can influence the pathogenic effects of stress. © 2014 Associated Professional Sleep Societies, LLC.

  14. Measuring Algorithm for the Distance to a Preceding Vehicle on Curve Road Using On-Board Monocular Camera

    Science.gov (United States)

    Yu, Guizhen; Zhou, Bin; Wang, Yunpeng; Wun, Xinkai; Wang, Pengcheng

    2015-12-01

    Due to more severe challenges of traffic safety problems, the Advanced Driver Assistance Systems (ADAS) has received widespread attention. Measuring the distance to a preceding vehicle is important for ADAS. However, the existing algorithm focuses more on straight road sections than on curve measurements. In this paper, we present a novel measuring algorithm for the distance to a preceding vehicle on a curve road using on-board monocular camera. Firstly, the characteristics of driving on the curve road is analyzed and the recognition of the preceding vehicle road area is proposed. Then, the vehicle detection and distance measuring algorithms are investigated. We have verified these algorithms on real road driving. The experimental results show that this method proposed in the paper can detect the preceding vehicle on curve roads and accurately calculate the longitudinal distance and horizontal distance to the preceding vehicle.

  15. Monocular inhibition reveals temporal and spatial changes in gene expression in the primary visual cortex of marmoset.

    Directory of Open Access Journals (Sweden)

    Yuki eNakagami

    2013-04-01

    Full Text Available We investigated the time course of the expression of several activity-dependent genes evoked by visual inputs in the primary visual cortex (V1 in adult marmosets. In order to examine the rapid time course of activity-dependent gene expression, marmosets were first monocularly inactivated by tetrodotoxin (TTX, kept in darkness for two days, and then exposed to various length of light stimulation. Activity-dependent genes including HTR1B, HTR2A, whose activity-dependency were previously reported by us, and well-known immediate early genes (IEGs, c-FOS, ZIF268, and ARC, were examined by in situ hybridization. Using this system, first, we demonstrated the ocular dominance type of gene expression pattern in V1 under this condition. IEGs were expressed in columnar patterns throughout layers II-VI of all the tested monocular marmosets. Second, we showed the regulation of HTR1B and HTR2A expressions by retinal spontaneous activity, because HTR1B and HTR2A mRNA expressions sustained a certain level regardless of visual stimulation and were inhibited by a blockade of the retinal activity with TTX. Third, IEGs dynamically changed its laminar distribution from half an hour to several hours upon a stimulus onset with the unique time course for each gene. The expression patterns of these genes were different in neurons of each layer as well. These results suggest that the regulation of each neuron in the primary visual cortex of marmosets is subjected to different regulation upon the change of activities from retina. It should be related to a highly differentiated laminar structure of primate visual systems, reflecting the functions of the activity-dependent gene expression in marmoset V1.

  16. Effects of colored light, color of comparison stimulus, and illumination on error in perceived depth with binocular and monocular viewing.

    Science.gov (United States)

    Huang, Kuo-Chen

    2007-06-01

    Two experiments assessed the effects of colored light, color of a comparison stimulus, and illumination on error in perceived depth with binocular and monocular vision. Exp. 1 assessed effects of colored light, color of comparison stimulus, and source of depth cues on error in perceived depth. A total of 29 women and 19 men, Taiwanese college or graduate students ages 20 to 30 years (M=24.0, SD= 2.5) participated; they were randomly divided into five groups, each being assigned to one of five possible colored light conditions. Analyses showed color of the comparison stimulus significantly affected the error in perceived depth, as this error was significantly greater for a red comparison stimulus than for blue and yellow comparison stimuli. Colored light significantly affected error in perceived depth since error under white and yellow light was significantly less than that under green light. Moreover, error in perceived depth under white light was significantly less than that under blue light but not sensitive to white, yellow, and red light. Error in perceived depth for binocular viewing was significantly less than that for monocular viewing but not sex. In Exp. 2, the effect of illumination on error in perceived depth was explored with 21 women and 15 men, Taiwanese college students with a mean age of 19.8 yr. (SD= 1.1). Analysis indicated that illumination significantly affected error in perceived depth, as error for a 40-W condition was significantly greater than under 20- and 60-W conditions, although the latter were not different.

  17. 散列算法MD5和SHA-1的比较%Comparison between MD5 and SHA-1

    Institute of Scientific and Technical Information of China (English)

    王泽; 曹莉莎

    2016-01-01

    MD5 and SHA-1 are the two known Hash Algorithm which are widely applied in information security, they are both developed from MD4.This paper introduces their algorithm logic in detail, compares them though simulation experiment ,soft-ware testing, etc. Finally, it draw a conclusion:The SHA-1 algorithm is more secure than the MD5 algorithm, but in the same hardware, SHA-1 is slower than MD5.%MD5和SHA-1是两个已知的广泛应用于信息安全的散列算法,均由MD4发展而来。详细介绍了它们的算法逻辑,并通过模拟实验、软件测试等方式对其在各个方面进行比较,最终得出结论:SHA-1算法比MD5算法的安全性更高,但在同一硬件上,SHA-1比MD5运行的要慢。

  18. Androgen deprivation therapy-associated vasomotor symptoms

    Institute of Scientific and Technical Information of China (English)

    Jason M Jones; Manish Kohli; Charles L Loprinzi

    2012-01-01

    Androgen deprivation therapy (ADT) is widely used as standard therapy in the treatment of locally advanced and metastatic prostate cancer.While efficacious,ADT is associated with multiple side effects,including decreased libido,erectile dysfunction,diabetes,loss of muscle tone and altered body composition,osteoporosis,lipid changes,memory loss,gynecomastia and hot flashes.The breadth of literature for the treatment of hot flashes is much smaller in men than that in women.While hormonal therapy of hot flashes has been shown to be effective,multiple non-hormonal medications and treatment methods have also been developed.This article reviews current options for the treatment of hot flashes in patients taking ADT.

  19. Socioeconomic deprivation and accident and emergency attendances

    DEFF Research Database (Denmark)

    Scantlebury, Rachel; Rowlands, Gillian; Durbaba, Stevo;

    2015-01-01

    BACKGROUND: Demand for England's accident and emergency (A&E) services is increasing and is particularly concentrated in areas of high deprivation. The extent to which primary care services, relative to population characteristics, can impact on A&E is not fully understood. AIM: To conduct...... a detailed analysis to identify population and primary care characteristics associated with A&E attendance rates, particularly those that may be amenable to change by primary care services. DESIGN AND SETTING: This study used a cross-sectional population-based design. The setting was general practices.......1, B = 547.3 [95% CI = 418.6 to 676.0]). The final model explained 34.4% of the variation in A&E attendance rates, mostly due to factors that could not be modified by primary care services. CONCLUSION: Demographic characteristics were the strongest predictors of A&E attendance rates. Primary care...

  20. MD1878: Operation with primary collimators at tighter settings

    CERN Document Server

    Mirarchi, Daniele; Biancacci, Nicolo; Bruce, Roderik; Buffat, Xavier; Carver, Lee Robert; Fiascaris, Maria; Mereghetti, Alessio; Redaelli, Stefano; Rossi, Roberto; Salvachua Ferrando, Belen Maria; Soderen, Martin; Trad, Georges

    2017-01-01

    Primary (TCP) collimators of the betatron cleaning insertion determine the betatron cut of the LHC beam. During the 2016 they were set at 5.5 nominal beam sigmas at 6.5 TeV (i.e. by using a normalized emittance " = 3:5 m is used). Reducing their settings is a possible way to push the at the LHC, which depends on the collimation hierarchy. This study aims at understanding possible limitations of operating the LHC with tighter settings of the primary collimators. This is a crucial input to the choice of operational conguration in terms of at the LHC as well as at the HL-LHC. This study follows a successful MD done in block 3 to understand limitations from TCP impedance [1]. The outcome of this MD can also have an impact for the design of the FCC collimation system, which is currently based on the present TCP gaps. Studies of beam stability as a function of octupole current, transverse feedback gain (ADT) and transverse separation at the IPs were also carried out.