Manifestations and management of veno-occlusive disease/sinusoidal obstruction syndrome in the era of contemporary therapies.

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Tewari, Priti; Wallis, Whitney; Kebriaei, Partow

2017-02-01

The concept of veno-occlusive disease (VOD), along with our understanding of it, has historically been and remains an evolving phenomenon. This review presents a broad view of VOD, also known as sinusoidal obstruction syndrome (SOS), including (1) traditional hematopoietic stem cell transplant-associated VOD/SOS, (2) late-onset VOD/SOS, (3) pulmonary VOD, and (4) VOD/SOS associated with chemotherapy only. Several VOD/SOS management modalities exist that include modes for both prophylaxis and treatment. An extensive review of the literature on monoclonal antibodies, both approved and pending approval by the US Food and Drug Administration, reveals that only a few have been associated with an increased risk for VOD/SOS. In fact, bevacizumab appears to have a protective effect against the development of VOD/SOS. As the landscape of cancer treatment changes, careful attention needs to be focused on how new therapies affect the incidence of VOD/SOS.

Cost-Effectiveness of Defibrotide in the Prophylaxis of Veno-Occlusive Disease after Pediatric Allogeneic Stem Cell Transplantation.

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Pichler, Herbert; Horner, Karolina; Engstler, Gernot; Poetschger, Ulrike; Glogova, Evgenia; Karlhuber, Susanne; Martin, Manuel; Eibler, Werner; Witt, Volker; Holter, Wolfgang; Matthes-Martin, Susanne

2017-07-01

Veno-occlusive disease (VOD) remains a serious complication after allogeneic hematopoietic stem cell transplantation (HSCT). Prophylactic use of defibrotide (DF) might further reduce VOD rates but has no impact on the incidence of severe VOD or VOD-associated mortality. We investigated the cost-effectiveness of prophylactic DF according to the British Committee for Standards in Haematology/British Society for Blood and Marrow Transplantation guidelines in 348 children who underwent transplantation between 2001 and 2014 in our hospital, 138 of whom were at risk for VOD. The VOD incidence was 7.4% for the total cohort. Patients at risk had a higher incidence of VOD compared with patients without risk factors (15.2% versus 2.4%, P < .0001). VOD occurred more often in patients after busulfan-based myeloablative conditioning than in patients after total body irradiation (11.2% versus 3.5%, P = .001). Donor types or the transplantation-related mortality (TRM) risk score did not correlate with VOD incidence. In 81% of patients who responded to therapeutic DF, VOD resolved completely. Overall VOD-associated mortality was .3% for the complete cohort, 3.7% for patients diagnosed with VOD, and 20% for patients with severe VOD. Neither the cumulative incidence of TRM (19% ± 8% versus 17% ± 2%, P = .706) nor the median length of hospitalization differed between patients with VOD and patients without. The median costs per HSCT in patients with VOD were about one-third higher than the overall median costs per transplantation at our institution. The calculated total costs of prophylactic DF treatment for 138 patients at risk was almost 6 times as high as the incremental costs for patients with VOD. We conclude that prophylactic DF for children at risk for VOD is not cost-effective with respect to TRM and length of hospital stay. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Hepatic veno-occlusive disease in pediatric stem cell transplantation: impact of pre-emptive antithrombin III replacement and combined antithrombin III/defibrotide therapy.

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Haussmann, Ursula; Fischer, Joachim; Eber, Stefan; Scherer, Franziska; Seger, Reinhard; Gungor, Tayfun

2006-06-01

Hepatic veno-occlusive disease (VOD) remains a serious complication after hematopoietic stem cell transplantation (HSCT). Based on a protective effect of antithrombin III (ATIII) on endothelial cells, we assessed the incidence of VOD after pre-emptive ATIII replacement and the outcome of VOD after combined high dose defibrotide (DF) and ATIII therapy. This prospective case series comprised two phases. In the first phase 71 children did not receive any specific VOD prophylaxis or therapy (controls). In the second phase 91 children were given pre-emptive ATIII replacement in case of decreased ATIII activity (defibrotide (60 mg/day) and ATIII replacement therapy were combined. The severity of VOD was determined according to the degree of multiple organ dysfunction. The incidence of VOD was similar in both groups (13/71, 18% vs. 14/91, 15%). All 14 patients in the second group who developed VOD showed decreased ATIII activity not more than 1 day prior to the clinical diagnosis of VOD. The resulting short duration of pre-emptive ATIII therapy failed to prevent VOD (OR 0.96). None of the patients (n=72) maintaining normal ATIII levels developed VOD. All 14 patients with VOD who received combined therapy achieved complete remission and 93 % (13/14) survived until day +100, compared to six survivors (46%) in the first group. Pre-emptive ATIII administration did not alter the incidence of VOD. Combination treatment with ATIII and defibrotide was safe and yielded excellent remission and survival rates.

Interacting Effects of Leaf Water Potential and Biomass on Vegetation Optical Depth

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Momen, M.; Wood, J. D.; Novick, K. A.; Pockman, W.; Konings, A. G.

2017-12-01

Remotely-sensed microwave observations of vegetation optical depth (VOD) have been widely used to examine vegetation responses to climate. Such studies have alternately found that VOD is sensitive to both biomass and canopy water content. However, the relative impacts of changes in phenology or water stress on VOD have not been disentangled. In particular, understanding whether leaf water potential (LWP) affects VOD may permit the assimilation of satellite observations into new large-scale plant hydraulic models. Despite extensive validation of the relationship between satellite-derived VOD estimates and vegetation density, relatively few studies have explicitly sought to validate the sensitivity of VOD to canopy water status, and none have studied the effect of variations in LWP on VOD. In this work, we test the sensitivity of VOD to variations in LWP, and present a conceptual framework which relates VOD to a combination of leaf water potential and total biomass including leaves, whose dynamics can be measured through leaf area index, and woody biomass. We used in-situ measurements of LWP data to validate the conceptual model in mixed deciduous forests in Indiana and Missouri, as well as a pinion-juniper woodland in New Mexico. Observed X-band VOD from the AMSR-E and AMSR2 satellites showed dynamics similar to those reconstructed VOD signals based on the new conceptual model which employs in-situ LWP data (R2=0.60-0.80). Because LWP data are not available at global scales, we further estimated ecosystem LWP based on remotely sensed surface soil moisture to better understand the sensitivity of VOD across ecosystems. At the global scale, incorporating a combination of biomass and water potential in the reconstructed VOD signal increased correlations with VOD about 15% compared to biomass alone and about 30% compared to water potential alone. In wetter regions with denser and taller canopy heights, VOD has a higher correlation with leaf area index than with water

Low, fixed dose defibrotide in management of hepatic veno-occlusive disease post stem cell transplantation.

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Bagal, Bhausaheb; Chandrasekharan, Arun; Chougle, Aliya; Khattry, Navin

2018-03-01

Hepatic veno-occlusive disease (VOD) is well recognized potentially serious regimen-related toxicity seen after stem cell transplantation. Severe VOD is associated with poor long-term outcomes with very high mortality. Besides supportive care, only defibrotide has been found to be effective in the management of VOD. The recommended dose of defibrotide is 25mg/kg/d but there has been no classical dose finding study done for this drug. A higher dose of defibrotide is associated with increased risk of bleeding and this drug is prohibitively expensive. We report our experience of using fixed low dose of defibrotide in patients with VOD. We retrospectively evaluated 511 patients who underwent stem cell transplant at our center from November 2007 and December 2015. All patients received ursodeoxycholic acid as VOD prophylaxis. Modified Seattle criterion was used for diagnosis and severity grading of VOD. Patients developing VOD were initially treated with furosemide and adequate analgesia. Defibrotide was started within 12 to 24 hours of diagnosis of VOD. All adult patients received defibrotide at a fixed dose of 200mg twice daily while two children were given dose of 100mg and 50mg twice daily. Nine (1.7%) of our patients developed VOD. Daily dose of defibrotide ranged from 5mg/kg/d to 20mg/kg/d till resolution of VOD. All patients had complete resolution of VOD. None of our patients required ventilator support or dialysis. No episodes of bleeding were observed. No dose response relationship was observed between defibrotide dose and time to resolution of VOD. Low fixed dose defibrotide initiated early seems to be effective and safe in treatment of VOD. This is relevant in a resource limited setting and warrants prospective evaluation. Copyright © 2017 King Faisal Specialist Hospital & Research Centre. Published by Elsevier B.V. All rights reserved.

Use of defibrotide in the treatment and prevention of veno-occlusive disease.

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Richardson, Paul; Linden, Erica; Revta, Carolyn; Ho, Vincent

2009-08-01

Hepatic veno-occlusive disease (VOD) is one of the most important complications of high-dose chemotherapy and stem cell transplantation. VOD is a clinical syndrome characterized by jaundice, hepatic enlargement and fluid retention typically seen by day +30 after transplantation. Severe VOD is complicated by multiorgan failure and a high mortality rate approaching 100%. Defibrotide (DF) is a novel agent with both antithrombotic and fibrinolytic properties that has emerged as an effective therapy for severe VOD. In Phase II studies, treatment of severe VOD has resulted in complete responses of 30-60% and survival past day 100 ranging between 32-50%. A Phase III, historically controlled study of DF for treatment of severe VOD has recently been completed and results are awaited with interest. In addition, DF may be effective prophylaxis for VOD in high-risk patients. This review will focus on a summary of the pharmacology of DF and the clinical evidence for its use in VOD.

Earlier defibrotide initiation post-diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome improves Day +100 survival following haematopoietic stem cell transplantation.

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Richardson, Paul G; Smith, Angela R; Triplett, Brandon M; Kernan, Nancy A; Grupp, Stephan A; Antin, Joseph H; Lehmann, Leslie; Miloslavsky, Maja; Hume, Robin; Hannah, Alison L; Nejadnik, Bijan; Soiffer, Robert J

2017-07-01

Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a progressive, potentially fatal complication of conditioning for haematopoietic stem cell transplant (HSCT). The VOD/SOS pathophysiological cascade involves endothelial-cell activation and damage, and a prothrombotic-hypofibrinolytic state. Severe VOD/SOS (typically characterized by multi-organ dysfunction) may be associated with >80% mortality. Defibrotide is approved for treating severe hepatic VOD/SOS post-HSCT in the European Union, and for hepatic VOD/SOS with renal or pulmonary dysfunction post-HSCT in the United States. Previously, defibrotide (25 mg/kg/day in 4 divided doses for a recommended ≥21 days) was available through an expanded-access treatment protocol for patients with VOD/SOS. Data from this study were examined post-hoc to determine if the timing of defibrotide initiation post-VOD/SOS diagnosis affected Day +100 survival post-HSCT. Among 573 patients, defibrotide was started on the day of VOD/SOS diagnosis in approximately 30%, and within 7 days in >90%. The relationship between Day +100 survival and treatment initiation before/after specific days post-diagnosis showed superior survival when treatment was initiated closer to VOD/SOS diagnosis with a statistically significant trend over time for better outcomes with earlier treatment initiation (P defibrotide should not be delayed after diagnosis of VOD/SOS. © 2017 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd.

Late-onset hepatic veno-occlusive disease post autologous peripheral stem cell transplantation successfully treated with oral defibrotide.

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Shah, Mithun S; Jeevangi, Nandish Kumar S; Joshi, Amit; Khattry, Navin

2009-01-01

Hepatic veno-occlusive disease (VOD) remains one of the commonest and most serious complications after myeloablative hematopoietic stem cell transplantation (HSCT). Clinical diagnosis of hepatic VOD is based on the finding of the triad of painful hepatomegaly, hyperbilirubinemia, and unexplained fluid retention occurring within 21 days of the transplant. However, the uncommon clinical entity of late-onset VOD can occur even beyond 20 days and should be considered in the differential diagnosis of any liver disease of more than 3 weeks' duration. While mild cases usually resolve spontaneously, severe VOD is associated with a grim prognosis. Defibrotide, a polydisperse mixture of single-stranded oligonucleotide with antithrombotic and fibrinolytic effects on microvascular endothelium, has emerged as an effective and safe therapy for patients with severe VOD. We describe a patient who presented 55 days post transplant with clinical features suggestive of VOD. Upon treatment with oral defibrotide, he showed complete resolution of the VOD.

Late-onset hepatic veno-occlusive disease post autologous peripheral stem cell transplantation successfully treated with oral defibrotide

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Shah Mithun

2009-01-01

Full Text Available Hepatic veno-occlusive disease (VOD remains one of the commonest and most serious complications after myeloablative hematopoietic stem cell transplantation (HSCT. Clinical diagnosis of hepatic VOD is based on the finding of the triad of painful hepatomegaly, hyperbilirubinemia, and unexplained fluid retention occurring within 21 days of the transplant. However, the uncommon clinical entity of late-onset VOD can occur even beyond 20 days and should be considered in the differential diagnosis of any liver disease of more than 3 weeks′ duration. While mild cases usually resolve spontaneously, severe VOD is associated with a grim prognosis. Defibrotide, a polydisperse mixture of single-stranded oligonucleotide with antithrombotic and fibrinolytic effects on microvascular endothelium, has emerged as an effective and safe therapy for patients with severe VOD. We describe a patient who presented 55 days post transplant with clinical features suggestive of VOD. Upon treatment with oral defibrotide, he showed complete resolution of the VOD.

Drivers of Global Vegetation Biomass Trends between 1988 and 2008

KAUST Repository

McCabe, Matthew; Liu, Yi; Evans, Jason; De Jeu, Richard; van Dijk, Albert

2013-01-01

Vegetation optical depth (VOD) is an indicator of the vegetation water content of both woody and leaf components in terrestrial biomass as derived from passive microwave observations. VOD is distinctly different from products derived from optical remote sensing: it is less prone to saturation in dense canopy; is sensitive to both photosynthetic and non-photosynthetic biomass; is less affected by atmospheric conditions; and is of coarser spatial resolution. Here, VOD retrievals from a series of sensors are blended to produce a time series from 1988 through to 2008, and a global analysis is undertaken to quantify and attribute global VOD trends over the same period. We conduct Mann-Kendall linear trend tests on annual average VOD to identify regions of significant change. Patterns for these regions were evaluated against independent datasets to diagnose the underlying cause of the observed trends. Results indicate that: (1) over grassland and shrubland, VOD patterns correspond strongly to temporal precipitation patterns; (2) over croplands, annual average VOD shows a general increase that corresponds to reported crop yield patterns and can be attributed to a combination of precipitation patterns and agricultural improvement; (3) over humid tropical forest, the spatial pattern of VOD decline agrees well with deforestation patterns identified in previous studies; and (4) over boreal forests, regional VOD declines can be attributed to a combination of fires and logging. We conclude that VOD can be used to estimate and interpret global changes in total above ground vegetation biomass. We expect that this new observationally based remote sensing data source will be of considerable interest to hydrological, agricultural, climate change and carbon cycle studies, and provide new insights into these and related process investigations.

Drivers of Global Vegetation Biomass Trends between 1988 and 2008

KAUST Repository

McCabe, Matthew

2013-12-01

Vegetation optical depth (VOD) is an indicator of the vegetation water content of both woody and leaf components in terrestrial biomass as derived from passive microwave observations. VOD is distinctly different from products derived from optical remote sensing: it is less prone to saturation in dense canopy; is sensitive to both photosynthetic and non-photosynthetic biomass; is less affected by atmospheric conditions; and is of coarser spatial resolution. Here, VOD retrievals from a series of sensors are blended to produce a time series from 1988 through to 2008, and a global analysis is undertaken to quantify and attribute global VOD trends over the same period. We conduct Mann-Kendall linear trend tests on annual average VOD to identify regions of significant change. Patterns for these regions were evaluated against independent datasets to diagnose the underlying cause of the observed trends. Results indicate that: (1) over grassland and shrubland, VOD patterns correspond strongly to temporal precipitation patterns; (2) over croplands, annual average VOD shows a general increase that corresponds to reported crop yield patterns and can be attributed to a combination of precipitation patterns and agricultural improvement; (3) over humid tropical forest, the spatial pattern of VOD decline agrees well with deforestation patterns identified in previous studies; and (4) over boreal forests, regional VOD declines can be attributed to a combination of fires and logging. We conclude that VOD can be used to estimate and interpret global changes in total above ground vegetation biomass. We expect that this new observationally based remote sensing data source will be of considerable interest to hydrological, agricultural, climate change and carbon cycle studies, and provide new insights into these and related process investigations.

Defibrotide for Treatment of Severe Veno-Occlusive Disease in Pediatrics and Adults: An Exploratory Analysis Using Data from the CIBMTR

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Strouse, Christopher; Richardson, Paul; Prentice, Grant; Korman, Sandra; Hume, Robin; Nejadnik, Bijan; Horowitz, Mary M.; Saber, Wael

2016-01-01

Veno-occlusive disease (VOD) is an early and serious complication of hematopoietic cell transplantation (HCT) that is associated with inferior survival, particularly when it is complicated by multi-organ failure (severe VOD). We evaluated the efficacy of defibrotide in the treatment of severe VOD using observational data from the Center for International Blood and Marrow Transplant Research (CIBMTR). Eight thousand three hundred forty-one patients treated by HCT between 2008 and 2011 were identified from the CIBMTR clinical database; 3.2% met criteria for VOD and 1.2% met criteria for severe VOD. Patients with a diagnosis of VOD as reported to the CIBMTR by their transplanting centers, who had no prior history of cirrhosis, and who had a maximum total bilirubin >2.0mg/dl by day +100 post-HCT were selected for study. Severe VOD was defined as VOD occurring in the setting of renal impairment requiring dialysis or any non-infectious pulmonary abnormality. Patients with severe VOD were divided into two groups for analysis: those treated with defibrotide (n=41) and those not treated with defibrotide (n=55). Patients in the non-defibrotide group were older, were more likely to be male, were more likely to have a history of previous fungal infection, and had a higher proportion of clinically significant pre-existing disease or organ impairment. Survival at day +100 was 39% (95% CI: 24.8–54.3%) in patients receiving defibrotide and 30.9% (95% CI: 19.5% – 43.6%) in those not receiving defibrotide. Resolution of VOD at day +100 was 51% in the defibrotide group, and 29% in the non-defibrotide group (difference 22.1%, 95% CI: 2.6% – 42%). The results of our study are consistent with previously reported experiences with defibrotide, confirm the poor outcome of this syndrome, and suggest defibrotide is effective in the treatment of severe VOD. PMID:27108694

Defibrotide for Treatment of Severe Veno-Occlusive Disease in Pediatrics and Adults: An Exploratory Analysis Using Data from the Center for International Blood and Marrow Transplant Research.

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Strouse, Christopher; Richardson, Paul; Prentice, Grant; Korman, Sandra; Hume, Robin; Nejadnik, Bijan; Horowitz, Mary M; Saber, Wael

2016-07-01

Veno-occlusive disease (VOD) is an early and serious complication of hematopoietic cell transplantation (HCT) that is associated with inferior survival, particularly when it is complicated by multiorgan failure (severe VOD). We evaluated the efficacy of defibrotide in the treatment of severe VOD using observational data from the Center for International Blood and Marrow Transplant Research (CIBMTR). Eight thousand three hundred forty-one patients treated by HCT between 2008 and 2011 were identified from the CIBMTR clinical database; 3.2% met criteria for VOD and 1.2% met criteria for severe VOD. Patients with a diagnosis of VOD as reported to the CIBMTR by their transplanting centers, who had no prior history of cirrhosis, and who had a maximum total bilirubin level > 2.0 mg/dL by day +100 post-HCT were selected for study. Severe VOD was defined as VOD occurring in the setting of renal impairment requiring dialysis or any noninfectious pulmonary abnormality. Patients with severe VOD were divided into 2 groups for analysis: those treated with defibrotide (n = 41) and those not treated with defibrotide (n = 55). Patients in the nondefibrotide group were older, were more likely to be male, were more likely to have a history of previous fungal infection, and had a higher proportion of clinically significant pre-existing disease or organ impairment. Survival rate at day +100 was 39% (95% CI, 24.8% to 54.3%) in patients receiving defibrotide and 30.9% (95% CI, 19.5% to 43.6%) in those not receiving defibrotide. Resolution rate of VOD at day +100 was 51% in the defibrotide group and 29% in the nondefibrotide group (difference, 22.1%; 95% CI, 2.6% to 42%). The results of our study are consistent with previously reported experiences with defibrotide, confirm the poor outcome of this syndrome, and suggest defibrotide is effective in the treatment of severe VOD. Copyright © 2016 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All

Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: update on defibrotide and other current investigational therapies.

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Ho, V T; Revta, C; Richardson, P G

2008-02-01

Hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), remains one of the most serious and common complications after myeloablative hematopoietic stem cell transplantation (HSCT). Clinical diagnosis of hepatic VOD is based on the clinical triad of (1) painful hepatomegaly, (2) hyperbilirubinemia and (3) unexplained fluid retention. While milder cases usually resolve spontaneously, severe VOD is associated with a grim prognosis. Defibrotide (DF), a polydisperse mixture of single-stranded oligonucleotide with antithrombotic and fibrinolytic effects on microvascular endothelium, has emerged as an effective and safe therapy for patients with severe VOD. Multiple studies, including a recent large international multicenter phase II clinical trial, have demonstrated 30-60% complete remission rates with DF, even among patients with severe VOD and multiorgan failure. This article will review our current understanding of hepatic VOD, and update the clinical trial experience with DF and other potential therapies for this feared transplant complication.

Exploiting the synergy between SMAP and SMOS to improve brightness temperature simulations and soil moisture retrievals in arid regions

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Ebrahimi, Mohsen; Alavipanah, Seyed Kazem; Hamzeh, Saeid; Amiraslani, Farshad; Neysani Samany, Najmeh; Wigneron, Jean-Pierre

2018-02-01

The objective of this study was to exploit the synergy between SMOS and SMAP based on vegetation optical depth (VOD) to improve brightness temperature (TB) simulations and land surface soil moisture (SM) retrievals in arid regions of the world. In the current operational algorithm of SMAP (level 2), vegetation water content (VWC) is considered as a proxy to compute VOD which is calculated by an empirical conversion function of NDVI. Avoiding the empirical estimation of VOD, the SMOS algorithm is used to retrieve simultaneously SM and VOD from TB observations. The present study attempted to improve SMAP TB simulations and SM retrievals by benefiting from the advantages of the SMOS (L-MEB) algorithm. This was achieved by using a synergy method based on replacing the default value of SMAP VOD with the retrieved value of VOD from the SMOS multi angular and bi-polarization observations of TB. The insitu SM measurements, used as reference SM in this study, were obtained from the International Soil Moisture Network (ISMN) over 180 stations located in arid regions of the world. Furthermore, four stations were randomly selected to analyze the temporal variations in VOD and SM. Results of the synergy method showed that the accuracy of the TB simulations and SM retrievals was respectively improved at 144 and 124 stations (out of a total of 180 stations) in terms of coefficient of determination (R2) and unbiased root mean squared error (UbRMSE). Analyzing the temporal variations in VOD showed that the SMOS VOD, conversely to the SMAP VOD, can better illustrate the presence of herbaceous plants and may be a better indicator of the seasonal changes in the vegetation density and biomass over the year.

Defibrotide in the prevention and treatment of veno-occlusive disease in autologous and allogeneic stem cell transplantation in children.

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Qureshi, Amrana; Marshall, Lynley; Lancaster, Donna

2008-04-01

Hepatic veno-occlusive disease (VOD) is a common (10-50%) and serious complication of haematological stem cell transplantation (HSCT), with up to 90% mortality rates. We carried out a study to assess whether the use of prophylactic defibrotide in paediatric patients undergoing HSCT results in a lower frequency or severity of hepatic VOD. Forty-seven successive patients who underwent transplantation between April 2004 and December 2005 were given defibrotide prophylaxis and were compared with 56 historical controls transplanted between November 2001 and April 2004. No serious side effects were reported. High risk patients in the control group received ursodeoxycholic acid and tinzaparin as VOD prophylaxis. The groups were matched for sex, age, type of transplant and risk. In the defibrotide group, four patients developed clinical VOD (Seattle criteria) although two had liver biopsies which showed graft versus host disease (GvHD). Defibrotide dose was increased and symptoms resolved within 14 days. Of the control group four patients had VOD. Two of these patients had reversed hepatic vein flow and died 30 days post-transplant, partly due to VOD. VOD was associated with busulfan conditioning (P = 0.001) and not with age, sex, type of transplant, GvHD, abnormal liver function prior to transplant or type of antifungal prophylaxis. VOD incidence and severity was reduced in the defibrotide group which suggests that defibrotide might be effective in preventing and treating VOD. Sufficiently powered randomised trials are now required to definitively test the role of defibrotide in this setting. (c) 2008 Wiley-Liss, Inc.

Defibrotide for the prevention of hepatic veno-occlusive disease after hematopoietic stem cell transplantation: a systematic review.

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Zhang, Lifei; Wang, Yebo; Huang, He

2012-01-01

Prophylactic use of defibrotide (DF) to prevent veno-occlusive disease (VOD), a relatively common and high-risk complication of hematopoietic stem cell transplantation (HSCT), may be an encouraging modality to reduce morbidity and mortality from VOD. However, conclusions remain unclear. We carried out a systematic review to summarize the state of knowledge. One randomized controlled trial (RCT), four cohort studies and eight case series studies were found, including a total of 1230 patients. The overall mean incidence of VOD in patients using DF was 4.7% (95% CI, 3.3-6.1) which was significantly lower than the data 13.7% (95% CI, 13.3-14.1) across 135 studies using no VOD prophylaxis (p < 0.005). The meta-analysis of the incidence of VOD in controlled trials revealed a statistical reduction in VOD incidence in the DF group (RR = 0.47, 95% CI, 0.31-0.73). The overall mean incidence of severe VOD was 0.8% (95% CI, 0.2-1.4). The RR was 0.31 (95% CI, 0.09-1.06). However, the lack of RCTs and the methodological weaknesses of the studies may preclude making generalizable conclusions. Our review described that DF appears promising for VOD prevention and large RCT is needed for further confirmation. © 2012 John Wiley & Sons A/S.

Defibrotide for the treatment of hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation.

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Corbacioglu, Selim; Kernan, Nancy; Lehmann, Leslie; Brochstein, Joel; Revta, Carolyn; Grupp, Stephan; Martin, Paul; Richardson, Paul G

2012-06-01

Hepatic veno-occlusive disease (VOD) is a serious complication of stem cell transplantation in children. VOD is characterized by rapid weight gain, hepatomegaly, hyperbilirubinemia and ascites. The pathogenesis of VOD is thought to involve chemotherapy and radiation-induced damage to the sinusoidal endothelium, resulting in endothelial injury, microthrombosis, subendothelial damage and cytokine activation. These processes lead to concomitant progressive hepatocellular dysfunction and subsequent fluid retention and renal impairment. Severe VOD is typically associated with multiorgan failure and high mortality. A number of possible strategies for the prevention and/or treatment of VOD in children have been investigated. The most promising agent to date is defibrotide, a novel polydeoxyribonucleotide with fibrinolytic properties but no major bleeding risk. Numerous studies, including Phase II/III trials, have shown clinical benefit in pediatric patients with the use of defibrotide treatment and prophylaxis. This review discusses VOD in children and focuses on therapeutic options, including defibrotide, in this patient population.

Safety and efficacy of defibrotide for the treatment of severe hepatic veno-occlusive disease.

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Richardson, Paul G; Ho, Vincent T; Giralt, Sergio; Arai, Sally; Mineishi, Shin; Cutler, Corey; Antin, Joseph H; Stavitzski, Nicole; Niederwieser, Dietger; Holler, Ernst; Carreras, Enric; Soiffer, Robert

2012-08-01

Hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome, is a potentially life-threatening complication of chemotherapeutic conditioning used in preparation for hematopoietic stem-cell transplantation (SCT). VOD may occur in up to 62% of patients undergoing SCT, with onset generally within the first month after SCT. In severe cases, 100-day mortality is in excess of 80%. Current management consists of best supportive care, with no agents to date approved for treatment in the USA or the EU. Defibrotide, a polydisperse oligonucleotide, has been shown in phase II and III trials to improve complete response and survival in patients undergoing SCT with severe VOD. This article reviews our current understanding of VOD, and examines recent clinical findings on defibrotide for the treatment and prophylaxis of VOD.

Combination of High-Dose Methylprednisolone and Defibrotide for Veno-Occlusive Disease in Pediatric Hematopoietic Stem Cell Transplant Recipients.

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Gloude, Nicholas J; Jodele, Sonata; Teusink-Cross, Ashley; Grimley, Michael; Davies, Stella M; Lane, Adam; Myers, Kasiani C

2018-01-01

Veno-occlusive disease (VOD) is a serious complication of hematopoietic stem cell transplant (HSCT), with high mortality in severe cases and until recently very limited therapeutic options consisting largely of supportive care. Defibrotide was recently approved in the United States for the treatment of severe VOD in patients with renal or pulmonary dysfunction after HSCT. Our group previously published on the use of high-dose methylprednisolone (500 mg/m 2 per dose every 12 hours for 6 doses) in patients with VOD, showing good success. A small subset of these individuals were also treated with defibrotide, but additional studies using the combination of high-dose methylprednisolone and defibrotide for the treatment of VOD are lacking. We present a single-institution retrospective chart review of 15 HSCT patients with VOD treated with the combination of high-dose methylprednisolone and defibrotide. VOD developed at a median of 17 days post-HSCT, and combination therapy was initiated within 1 day of VOD diagnosis. Twelve of 15 patients (80%) had multiorgan failure. Our single-center experience using both high-dose methylprednisolone and defibrotide showed a day +100 survival rate of 73% and an overall VOD complete resolution rate of 66.7%, higher than the rates reported in the recent literature using defibrotide alone (40% to 50% day +100 overall survival). These data suggest that the combination of high-dose steroids and defibrotide may be superior to defibrotide alone and warrant further investigation. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Prevention of veno-occlusive disease with defibrotide after allogeneic stem cell transplantation.

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Chalandon, Yves; Roosnek, Eddy; Mermillod, Bernadette; Newton, Anita; Ozsahin, Hulya; Wacker, Pierre; Helg, Claudine; Chapuis, Bernard

2004-05-01

Veno-occlusive disease (VOD) of the liver occurs in 10% to 50% of patients after allogeneic stem cell transplantation, ranging from mild reversible disease to severe disease, with a mortality rate almost always close to 100%. Recently, promising results in the treatment of established VOD with defibrotide were reported. Therefore, defibrotide may be used as a prophylactic regimen for hepatic VOD in stem cell transplantation for hematologic malignancies. Fifty-two successive patients who underwent transplantation between October 1999 and June 2002 received defibrotide prophylaxis intravenously from day -7 to day +20 after transplantation in addition to heparin and were compared with historical controls who underwent transplantation successively between February 1997 and September 1999. In the defibrotide group, the maximum total bilirubin levels and the number of patients with serum levels exceeding 50 micromol/L were significantly lower than in the control group (5 of 52 versus 18 of 52, respectively; P =.004). None of the 52 patients developed VOD (Baltimore criteria), and no side effects occurred. These results were significantly different (P =.001) from controls (10/52 [19%] with VOD, 3 of whom died of severe VOD). In addition, day 100 event-free survival was significantly higher in the study group (P =.02), with a trend toward better day 100 overall survival (P =.07). These results suggest that defibrotide given in addition to heparin may be an efficient prophylaxis for VOD.

High-Dose Methylprednisolone for Veno-Occlusive Disease of the Liver in Pediatric Hematopoietic Stem Cell Transplantation Recipients

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Myers, Kasiani C.; Lawrence, Julia; Marsh, Rebecca A.; Davies, Stella M.; Jodele, Sonata

2017-01-01

Veno-occlusive disease (VOD) of the liver is a well-recognized serious complication of hematopoietic stem cell transplantation (HSCT), with few successful treatment modalities available for severe disease. Some reports have demonstrated success in adults with the use of high-dose steroid therapy, but experience in the pediatric population is lacking. We retrospectively reviewed HSCT patients treated at our institution since 2003 and identified 15 (2.4%) who developed VOD. Of these, nine (60%) were treated with intravenous high-dose methylprednisolone (500 mg/m2 per dose every 12 hours for six doses). Steroid therapy was initiated at or before first ultrasound evidence of reversal of portal venous flow and before meeting criteria for initiation of defibrotide therapy. Four patients were also treated with defibrotide starting 2 to 5 days after initiation of steroids. Eight of nine patients (88%) with VOD were diagnosed with multiorgan failure. Response to high-dose steroid therapy as defined by decrease in bilirubin by 50% in 10 days from therapy initiation was noted in six of nine patients (67%), occurring within 3 to 6 days of steroid therapy. Two patients died from multiorgan failure due to VOD. Seven survivors of VOD recovered at the median 6 days (range, 5 to 38) from VOD diagnosis. Overall, VOD survival as a group was 78%; however, survival among responders was 100%. No serious toxicities related to high-dose steroid therapy were observed. We conclude that high-dose steroid therapy if initiated early may reverse VOD of the liver in pediatric HSCT patients, abrogating the need for defibrotide therapy with its associated toxicities and regulatory difficulties. PMID:23211838

Defibrotide sodium for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome.

Science.gov (United States)

Richardson, Paul G; Triplett, Brandon M; Ho, Vincent T; Chao, Nelson; Dignan, Fiona L; Maglio, Michelle; Mohty, Mohamad

2018-02-01

Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is an unpredictable condition associated with endothelial-cell damage due to conditioning for hematopoietic stem-cell transplantation (HSCT) or chemotherapy without HSCT. Mortality in patients with VOD/SOS and multi-organ dysfunction (MOD) may be >80%. Areas covered: Defibrotide is the only approved drug for the treatment of severe hepatic VOD/SOS after HSCT in the European Union and hepatic VOD/SOS with renal or pulmonary dysfunction in the United States. Its efficacy in patients with VOD/SOS with MOD post-HSCT was demonstrated in a clinical-trial program that included a historically controlled treatment study, a phase 2 trial, and a large T-IND expanded-access program that also included patients without MOD and who received chemotherapy without HSCT. Expert commentary: Defibrotide appears to protect endothelial cells and restore the thrombolytic-fibrinolytic balance. It addresses a significant clinical need and has demonstrated favorable Day +100 survival and overall adverse-event rates that seem similar to control groups receiving supportive care alone. Currently, defibrotide is under investigation for the prevention of VOD/SOS in high-risk pediatric and adult patients.

Drug safety evaluation of defibrotide.

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Richardson, Paul G; Corbacioglu, Selim; Ho, Vincent Trien-Vinh; Kernan, Nancy A; Lehmann, Leslie; Maguire, Craig; Maglio, Michelle; Hoyle, Margaret; Sardella, Marco; Giralt, Sergio; Holler, Ernst; Carreras, Enric; Niederwieser, Dietger; Soiffer, Robert

2013-01-01

Hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), is a potentially life-threatening complication of chemotherapeutic conditioning used in preparation for hematopoietic stem-cell transplantation (SCT). Defibrotide (DF) has been shown in Phase II and III trials to improve complete response in patients with severe VOD (sVOD). None of the articles, to date, provide a comprehensive review of the safety of DF in VOD and/or a range of other conditions. This article reviews current clinical findings on DF, primarily in terms of safety for use in treatment and prophylaxis of VOD, and relevant safety data for its use in other diseases. The literature review was conducted using a PubMed search with the fixed term 'defibrotide' in combination with ≥ 1 of 'safety', 'veno-occlusive disease' (with and without 'treatment', 'prevention'), 'oncology', 'myeloma', 'microangiopathy', 'anti-thrombotic' and 'peripheral vascular disorder'. Related articles from the EBMT and ASH conference websites were also included. DF was well tolerated in majority of the studies. The safety profile of DF is largely favourable with toxicities comparable to control populations in the setting of SCT complicated by sVOD.

PRZEBIEG SYMULACJI KOMPUTEROWEJ PROCESU OCZYSZCZANIA SCIEKÓW KOMUNALNYCH W REAKTORZE OSADU CZYNNEGO

Directory of Open Access Journals (Sweden)

Zbigniew KOWALEWSKI

2016-05-01

Full Text Available Celem badań było ustalenie wpływu ilości i zakresu parametrów jakości ścieków surowych na wiarygodność wyników symulacji, co umożliwiłoby ustalenie optymalnej częstotliwości ich monitoringu, niezbędnego do pozyskiwania danych do modelowania w programach ASM. W artykule przedstawiono metodykę prowadzenia symulacji komputerowej procesu oczyszczania ścieków komunalnych w reaktorach biologicznych z osadem czynnym. Zaprezentowano sposób przygotowania i przetwarzania danych wejściowych do modelu oraz sposoby oceny i weryfikacji wyników symulacji za pomocą testów statystycznych. Modelowanie było wykonane w programie BioWin na przykładzie oczyszczalni ścieków komunalnych „Kujawy” w Krakowie. W oparciu o wstępne wyniki niniejszych badań można wnioskować, że w celu uzyskania wiarygodnych wyników symulacji pracy bioreaktora w modelu ASM niezbędne jest prowadzenie monitoringu podstawowych paramentów jakości ścieków online.

The Relationship of Temporal Variations in SMAP Vegetation Optical Depth to Plant Hydraulic Behavior

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Konings, A. G.

2016-12-01

The soil emissions measured by L-band radiometers such as that on the NASA Soil Moisture Active/Passive mission are modulated by vegetation cover as quantified by the soil scattering albedo and the vegetation optical depth (VOD). The VOD is linearly proportional to the total vegetation water content, which is dependent on both the biomass and relative water content of the plant. Biomass is expected to vary more slowly than water content. Variations in vegetation water content are highly informative as they are directly indicative of the degree of hydraulic stress (or lack thereof) experienced by the plant. However, robust retrievals are needed in order for SMAP VOD observations to be useful. This is complicated by the fact that multiple unknowns (soil moisture, VOD, and albedo) need to be determined from two highly correlated polarizations. This presentation will discuss the application to SMAP of a recently developed timeseries algorithm for VOD and albedo retrieval - the Multi-Temporal Dual Channel Algorithm MTDCA, and its interpretation for plant hydraulic applications. The MT-DCA is based on the assumption that, for consecutive overpasses at a given time of day, VOD varies more slowly than soil moisture. A two-overpass moving average can then be used to determine variations in VOD that are less sensitive to high-frequency noise than classical dual-channel algorithms. Seasonal variations of SMAP VOD are presented and compared to expected patterns based on rainfall and radiation seasonality. Taking advantage of the large diurnal variation (relative to the seasonal variation) of canopy water potention, diurnal variations (between 6AM and 6PM observations) of SMAP VOD are then used to calculate global variations in ecosystem-scale isohydricity - the degree of stomatal closure and xylem conductivity loss in response to water stress. Lastly, the effect of satellite sensing frequency and overpass time on water content across canopies of different height will be

Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: review and update on the use of defibrotide.

Science.gov (United States)

Ho, Vincent T; Linden, Erica; Revta, Carolyn; Richardson, Paul G

2007-06-01

Veno-occlusive disease (VOD) of the liver remains one of the most feared complications associated with high-dose chemotherapy and hematopoietic stem cell transplantation (SCT). As a clinical syndrome characterized by fluid retention, hyperbilirubinemia, and painful hepatomegaly, VOD incidence varies widely, but it is universally recognized that severe cases of VOD have an extremely poor prognosis, with mortality at day 100 after SCT in excess of 80%. Systemic anticoagulant and thrombolytic therapies have been tested extensively in this disease, but are largely ineffective and are associated with significant bleeding complications. In recent years, defibrotide (DF; a polydisperse oligonucleotide derived from porcine intestinal mucosa with antithrombotic and protective properties on the microvasculature but minimal hemorrhagic risk) has emerged as a promising therapy for VOD. In large, multicenter, international phase I/II trials targeting patients with severe VOD, DF has been associated with complete response rates between 36 and 60%, survival past transplant day 100 in the range of 32 to 50%, and few significant attributable side effects. On the basis of these encouraging results, a pivotal, prospective, multinational, phase III trial of DF is underway in patients with severe VOD, and should provide validation of this agent as a therapy for established disease with a high risk of mortality. This article reviews our current understanding of hepatic VOD after SCT and provides a summary of the data to date on the use of DF as both therapy and prophylaxis for this disease.

Late-Onset Hepatic Veno-Occlusive Disease after Allografting: Report of Two Cases with Atypical Clinical Features Successfully Treated with Defibrotide.

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Castellino, Alessia; Guidi, Stefano; Dellacasa, Chiara Maria; Gozzini, Antonella; Donnini, Irene; Nozzoli, Chiara; Manetta, Sara; Aydin, Semra; Giaccone, Luisa; Festuccia, Moreno; Brunello, Lucia; Maffini, Enrico; Bruno, Benedetto; David, Ezio; Busca, Alessandro

2018-01-01

Hepatic Veno-Occlusive Disease (VOD) is a potentially severe complication of hematopoietic stem cell transplantation (HSCT). Here we report two patients receiving an allogeneic HSCT who developed late onset VOD with atypical clinical features. The two patients presented with only few risk factors, namely, advanced acute leukemia, a myeloablative busulphan-containing regimen and received grafts from an unrelated donor. The first patient did not experience painful hepatomegaly and weight gain and both patients showed only a mild elevation in total serum bilirubin level. Most importantly, the two patients developed clinical signs beyond day 21 post-HSCT. Hepatic transjugular biopsy confirmed the diagnosis of VOD. Intravenous defibrotide was promptly started leading to a marked clinical improvement. Based on our experience, liver biopsy may represent a useful diagnostic tool when the clinical features of VOD are ambiguous. Early therapeutic intervention with defibrotide represents a crucial issue for the successful outcome of patients with VOD.

Late-onset hepatic veno-occlusive disease after allografting: report of two cases with atypical clinical features successfully treated with defibrotide.

Directory of Open Access Journals (Sweden)

Alessia Castellino

2018-01-01

Full Text Available Hepatic Veno-occlusive disease (VOD is a potentially severe complication of hematopoietic stem cell transplantation (HSCT. Here we report two patients receiving an allogeneic HSCT  who developed late onset VOD with atypical clinical features. The two  patients presented with only few risk factors, namely, advanced acute leukemia, a myeloablative busulphan-containing regimen and received grafts from an unrelated donor. The first patient did not experience painful hepatomegaly and weight gain and both  patients showed only a mild elevation in total serum bilirubin level. Most importantly, the two patients developed clinical signs beyond day 21 post-HSCT. Hepatic transjugular biopsy confirmed the diagnosis of VOD. Intravenous defibrotide was promptly started leading to a marked clinical improvement. Based on our experience, liver biopsy may represent a useful diagnostic tool when the clinical features of VOD are ambiguous. Early therapeutic intervention with defibrotide  represents a crucial issue for the successful outcome of patients with VOD.

Defibrotide for Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease Prophylaxis in High-Risk Adult Patients: A Single-Center Experience Study.

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Picod, Adrien; Bonnin, Agnès; Battipaglia, Giorgia; Giannotti, Federica; Ruggeri, Annalisa; Brissot, Eolia; Malard, Florent; Médiavilla, Clémence; Belhocine, Ramdane; Vekhoff, Anne; Gueye, Mor Sény; Lapusan, Simona; Adaeva, Rosa; Isnard, Françoise; Legrand, Ollivier; Baylatry, Minh-Tam; Joly, Anne-Christine; Labopin, Myriam; Duléry, Rémy; Mohty, Mohamad

2018-03-01

Sinusoidal obstruction syndrome (SOS), also known as hepatic veno-occlusive disease (VOD), is a serious complication after hematopoietic stem cell transplantation (HSCT). SOS/VOD usually occurs within 3 weeks of HSCT, but the 2016 European Society for Blood and Marrow Transplantation diagnosis criteria have been revised to include late forms. Prophylactic use of defibrotide is recommended in the pediatric setting, but its value remains uncertain in the adult population. We report here a single-center series of 63 adult patients considered at high risk for SOS/VOD who received defibrotide prophylaxis in combination with ursodeoxycholic acid between May 2012 and August 2016. The median duration of defibrotide therapy was 23 days. Bleeding occurred in 14 patients (21.5%). Defibrotide prophylaxis was discontinued in 7 patients (10.8%): 4 cases (6.3%) due to bleeding and 3 cases (4.6%) because of the need for antithrombotic therapy. Overall, SOS/VOD occurred in 4 cases (6.3%) within 21 days after HSCT (days 13 and 14) in 2 cases and late-onset SOS/VOD (days 57 and 58) in the other 2 cases. SOS/VOD was moderate in 1 case, very severe in 3 cases, with 2 deaths related to SOS/VOD. Cumulative incidence of grades II to IV acute graft-versus-host disease and transplant-associated thrombotic microangiopathy were 22.2% and 3.2%, respectively. With a median follow-up of 31 months (range, 10.7 to 60.3), the rates of 2-year overall survival, progression-free survival, incidence of relapse, and nonrelapse mortality were 56.5%, 49%, 28.7%, and 22.3%, respectively. In our experience defibrotide prophylaxis is associated with a low incidence of SOS/VOD after allogeneic HSCT in a high-risk adult population with an acceptable safety profile. Copyright © 2018 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Veno-Occlusive Disease of the Liver in the Absence of Elevation in Bilirubin in Pediatric Patients after Hematopoietic Stem Cell Transplantation

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Myers, Kasiani C.; Dandoy, Christopher; El-Bietar, Javier; Davies, Stella M.; Jodele, Sonata

2016-01-01

Veno-occlusive disease (VOD) of the liver is a well-described and significant complication of hematopoietic stem cell transplantation (HSCT), with limited successful therapeutic options in severe cases. Prompt diagnosis and initiation of treatment is crucial to restrict the extent of disease. However, a subset of patients may not meet all current diagnostic criteria at presentation, and waiting for these to be met may delay therapy. We retrospectively reviewed 794 HSCT patients treated at our institution between 2003 and 2013, identifying 17 (2.1%) who developed VOD. Of these, 5 (29%) were noted to have an absence of elevated bilirubin at the time of VOD diagnosis and reversal of portal venous flow on ultrasound. Median total and conjugated bilirubin at VOD diagnosis were 1.0 and 0.2 mg/dL, respectively. All 5 patients were subsequently diagnosed with multiorgan failure associated with VOD, including 1 with encephalopathy. Four were treated with intravenous high-dose methylprednisolone (500 mg/m2 per dose every 12 hours for 6 doses). One patient received defibrotide therapy in addition to steroids and another supportive care alone. VOD resolved in 4 of 5 patients, with median time to resolution of VOD, defined as recovery of all organ function and normalization of bilirubin and portal venous flow, of 8 days. Two patients died later from progressive primary disease and chronic graft-versus-host disease, respectively. We conclude that a high index of suspicion for VOD should be maintained in patients despite lack of bilirubin elevation in the presence of other diagnostic criteria such as hepatomegaly, abdominal pain, ascites, or weight gain. Early ultrasound evaluation in these patients may lead to more timely diagnosis and therapeutic interventions. PMID:25300869

Defibrotide for children and adults with hepatic veno-occlusive disease post hematopoietic cell transplantation.

Science.gov (United States)

Corbacioglu, Selim; Richardson, Paul G

2017-10-01

Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a complication that is typically associated with conditioning for hematopoietic stem cell transplantation (HSCT). In patients with concomitant multi-organ dysfunction, mortality may be >80%. Recently, the European Society for Blood and Marrow Transplantation established separate criteria for diagnosis and severity of VOD/SOS for adults and children, to better reflect current understanding of the disease. Areas covered: This review provides an overview of post-HSCT hepatic VOD/SOS and defibrotide, including its pharmacological, clinical, and regulatory profile. In children and adults following HSCT, defibrotide is approved for the treatment of hepatic VOD/SOS with concomitant renal or pulmonary dysfunction in the United States and for the treatment of severe hepatic VOD/SOS in the European Union. Day +100 survival rates with defibrotide are superior to those of historical controls receiving best supportive care only, and safety profiles are similar. Expert commentary: Defibrotide appears to act through multiple mechanisms to restore thrombo-fibrinolytic balance and protect endothelial cells, and there are promising data on the use of defibrotide for VOD/SOS prophylaxis in high-risk children undergoing HSCT. An ongoing randomized controlled trial in children and adults will better assess the clinical value of defibrotide as a preventive medication.

Early stellate cell activation and veno-occlusive-disease (VOD)-like hepatotoxicity in dogs treated with AR-H047108, an imidazopyridine proton pump inhibitor.

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Berg, Anna-Lena; Böttcher, Gerhard; Andersson, Kjell; Carlsson, Enar; Lindström, Anna-Karin; Huby, Russell; Håkansson, Helen; Skånberg-Wilhelmsson, Inger; Hellmold, Heike

2008-07-01

Dogs treated with AR-H047108, an imidazopyridine potassium competitive acid blocker (P-CAB), developed clinical signs of hepatic dysfunction as well as morphologically manifest hepatotoxicity in repeat-dose toxicity studies. An investigative one-month study was performed, with interim euthanasia after one and two weeks. A detailed histopathological and immunohistochemical characterization of the liver lesions was conducted, including markers for fibrosis, Kupffer cell activation, apoptosis, and endothelial injury. In addition, hepatic retinoid and procollagen 1alpha2 mRNA levels in livers of dogs treated with AR-H047108 were analyzed. The results showed an early inflammatory process in central veins and centrilobular areas, present after one week of treatment. This inflammatory reaction was paralleled by activation of stellate/Ito cells to myofibroblasts and was associated with sinusoidal and centrivenular fibrosis. The early activation of stellate cells coincided with a significant decrease in retinyl ester levels, and a significant increase in procollagen 1alpha2 mRNA levels, in the liver. At later time points (three and six months), there was marked sinusoidal fibrosis in centrilobular areas, as well as occlusion of central veins resulting from a combination of fibrosis and increased thickness of smooth muscle bundles in the vessel wall. The pattern of lesions suggests a veno-occlusive-disease (VOD)-like scenario, possibly linked to the imidazopyridine chemical structure of the compound facilitated by specific morphological features of the dog liver.

Distribution of Video-on-Demand Service over Cable Television Networks

Directory of Open Access Journals (Sweden)

L. T. Jordanova

2009-06-01

Full Text Available The paper deals with investigations carried out to increase the effectiveness of video-on-demand (VoD systems when cable television networks are used. A comparative analysis of the existing VoD architectures is made with respect to the equipment cost and the traffic load over the central transport network. Through statistical studies the main characteristics of a particular hybrid VoD are determined (such as twenty-four-hour distribution of the video traffic, average inter-arrival time of the VoD requests, average duration of video streams demanded, movies distribution according to the subscribers’ preferences. An algorithm for the videocontent flexible distribution among the distribution hubs is suggested. Thus a higher effectiveness of the system is achieved without significantly increasing the equipment cost.

Consensus Report by Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplantation Consortium Joint Working Committees: Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents, Part 1: Focus on Investigations, Prophylaxis, and Specific Treatment.

Science.gov (United States)

Bajwa, Rajinder P S; Mahadeo, Kris M; Taragin, Benjamin H; Dvorak, Christopher C; McArthur, Jennifer; Jeyapalan, Asumthia; Duncan, Christine N; Tamburro, Robert; Gehred, Alison; Lehmann, Leslie; Richardson, Paul; Auletta, Jeffery J; Woolfrey, Ann E

2017-11-01

Veno-occlusive disease (VOD) is a common and potentially fatal complication in children undergoing hematopoietic cell transplantation (HCT). It occurs in about one-third of all patients undergoing transplantation and is fatal in 50% of patients with severe disease. Early intervention and specific treatment with defibrotide are associated with improved outcomes. However, there is a lack of supportive care guidelines for management of the multiorgan dysfunction seen in most cases. There is high variability in the management of VOD, which may contribute to the increased morbidity and mortality. Although there is ample research in the specific treatment of VOD, there is paucity of literature regarding the management of ascites, transfusions requirements, fluids and electrolyte dysfunction, delirium, and investigations in children with VOD. The joint working committees of the Pediatric Acute Lung Injury and Sepsis Investigators and the Pediatric Blood and Marrow Transplantation Consortium collaborated to develop a series of evidence-based supportive care guidelines for management of VOD. The quality of evidence was rated and recommendations were made using Grading of Recommendations, Assessment, Development and Evaluation criteria. This manuscript is part 1 of the series and focuses on the need to develop these guidelines; methodology used to establish the guidelines; and investigations needed for diagnosis, prophylaxis, and treatment of VOD in children. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Defibrotide: a review of its use in severe hepatic veno-occlusive disease following haematopoietic stem cell transplantation.

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Keating, Gillian M

2014-12-01

Defibrotide (Defitelio(®)) was recently approved in the EU for the treatment of severe hepatic veno-occlusive disease (VOD), also known as sinusoidal obstructive syndrome, in haematopoietic stem cell transplantation (HSCT) therapy. It is indicated in adults, adolescents, children and infants over 1 month of age. Defibrotide is also available in the US via an expanded-access protocol. Defibrotide is thought to protect endothelial cells and restore the thrombo-fibrinolytic balance in VOD. In a multicentre, phase III trial, the complete response rate by day +100 (primary endpoint) was significantly higher, and mortality at day +100 was significantly lower, in patients with severe hepatic VOD and multiorgan failure following HSCT who received intravenous defibrotide 6.25 mg/kg every 6 h than in a group of historical controls. The efficacy of defibrotide in severe hepatic VOD following HSCT was also supported by findings from a phase II dose-finding study, compassionate-use data and information provided from an independent transplant registry. Intravenous defibrotide was generally well tolerated in patients with severe hepatic VOD following HSCT, and was not associated with an increased risk of haemorrhagic adverse events. In conclusion, defibrotide is the only agent approved (in the EU) for use in severe hepatic VOD following HSCT and represents a useful advance in the treatment of this condition.

[Central blood pressure and vascular damage].

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Pérez-Lahiguera, Francisco; Rodilla, Enrique; Costa, José Antonio; Pascual, José María

2015-07-20

The aim of this study was to assess the relationship between central blood pressure and vascular damage. This cross-sectional study involved 393 never treated hypertensive patients (166 women). Clinical blood pressure (BP), 24h blood pressure (BP24h) and central blood pressure (CBP) were measured. Vascular organ damage (VOD) was assessed by calculating the albumin/creatinine ratio (ACR), wave pulse pressure velocity and echocardiographic left ventricular mass index (LVMI). Patients with VOD had higher values of BP, BP24h, and CBP than patients without ACR. When comparing several systolic BP, systolic BP24h had a higher linear correlation with CBP (Z Steiger test: 2.26; P=.02) and LVMI (Z Steiger test: 3.23; P=.01) than PAC. In a multiple regression analysis corrected by age, sex and metabolic syndrome, all pressures were related with VOD but systolic BP24h showed the highest correlation. In a logistic regression analysis, having the highest tercile of systolic BP24h was the stronger predictor of VOD (multivariate odds ratio: 3.4; CI 95%: 2.5-5.5, P=.001). CBP does not have more correlation with VOD than other measurements of peripheral BP. Systolic BP24h is the BP measurement that best predicts VOD. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

Defibrotide for the management of sinusoidal obstruction syndrome in patients who undergo haemopoietic stem cell transplantation.

Science.gov (United States)

Coutsouvelis, John; Avery, Sharon; Dooley, Michael; Kirkpatrick, Carl; Spencer, Andrew

2016-11-01

Sinusoidal obstruction syndrome, previously known as veno-occlusive disease (VOD/SOS), is a complication in patients undergoing haemopoietic stem cell transplantation (HSCT). Severe VOD/SOS, including progression to multi-organ failure, has resulted in a mortality of greater than 80%. Defibrotide's varying pharmacological actions, particularly on endothelial cells, make it is a useful agent to consider for prophylaxis and treatment of VOD/SOS. Barriers to its routine use include the high acquisition cost and the fact that neither the oral or parenteral formulations are licensed products in many countries at this time. This review summarises available literature on the use of defibrotide in the management of VOD/SOS. Publications consist predominantly of single centre cohort studies and case series. Available evidence indicates that defibrotide is effective in the management of VOD/SOS. Using defibrotide prophylaxis should also be considered, especially in the paediatric setting, where there are available results from a large, open label, randomized controlled trial. Patient outcome data from the larger studies and compassionate programs can inform consensus recommendations on dosing regimen and criteria for the treatment of VOD/SOS with defibrotide in the adult population. The reviewed literature indicates an effective and safe dose for treatment is 25mg/kg/day, continued for at least 14days or until complete response is achieved. Further studies are required to determine the optimal dose and duration of treatment in both paediatric patients and adults. Recent recommendations and a phase 3 trial using historical controls indicate that defibrotide should be included as a pharmacotherapy option in protocols guiding management of VOD/SOS. Copyright © 2016 Elsevier Ltd. All rights reserved.

Defibrotide for the Treatment of Hepatic Veno-Occlusive Disease : Final Results From the International Compassionate-Use Program

NARCIS (Netherlands)

Corbacioglu, Selim; Carreras, Enric; Mohty, Mohamad; Pagliuca, Antonio; Boelens, Jaap Jan; Damaj, Gandhi; Iacobelli, Massimo; Niederwieser, Dietger; Olavarría, Eduardo; Suarez, Felipe; Ruutu, Tapani; Verdonck, Leo; Hume, Robin; Nejadnik, Bijan; Lai, Chinglin; Finetto, Giorgia; Richardson, Paul

2016-01-01

Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is an unpredictable and potentially fatal complication of hematopoietic cell transplantation (HCT) or nontransplantation-associated chemotherapy/radiotherapy. In cases of severe hepatic VOD/SOS, typically defined

Veno-occlusive disease nurse management: development of a dynamic monitoring tool by the GITMO nursing group.

Science.gov (United States)

Botti, Stefano; Orlando, Laura; Gargiulo, Gianpaolo; Cecco, Valentina De; Banfi, Marina; Duranti, Lorenzo; Samarani, Emanuela; Netti, Maria Giovanna; Deiana, Marco; Galuppini, Vera; Pignatelli, Adriana Concetta; Ceresoli, Rosanna; Vedovetto, Alessio; Rostagno, Elena; Bambaci, Marilena; Dellaversana, Cristina; Luminari, Stefano; Bonifazi, Francesca

2016-01-01

Veno-occlusive disease (VOD) is a complication arising from the toxicity of conditioning regimens that have a significant impact on the survival of patients who undergo stem cell transplantation. There are several known risk factors for developing VOD and their assessment before the start of conditioning regimens could improve the quality of care. Equally important are early identification of signs and symptoms ascribable to VOD, rapid diagnosis, and timely adjustment of support therapy and treatment. Nurses have a fundamental role at the stages of assessment and monitoring for signs and symptoms; therefore, they should have documented skills and training. The literature defines nurses' areas of competence in managing VOD, but in the actual clinical practice, this is not so clear. Moreover, there is an intrinsic difficulty in managing VOD due to its rapid and often dramatic evolution, together with a lack of care tools to guide nurses. Through a complex evidence-based process, the Gruppo Italiano per il Trapianto di Midollo Osseo (GITMO), cellule staminali emopoietiche e terapia cellulare nursing board has developed an operational flowchart and a dynamic monitoring tool applicable to haematopoietic stem cell transplantation patients, whether they develop this complication or not.

Prophylactic defibrotide in allogeneic stem cell transplantation: minimal morbidity and zero mortality from veno-occlusive disease.

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Dignan, F; Gujral, D; Ethell, M; Evans, S; Treleaven, J; Morgan, G; Potter, M

2007-07-01

Veno-occlusive disease (VOD) is a common and high-risk complication of allogeneic stem cell transplantation (SCT). Defibrotide has recently been used successfully to treat the disorder. We report on 58 patients who received defibrotide prophylaxis without concurrent heparin. No patients fulfilled the Baltimore criteria for VOD or died of the condition within 100 days of SCT. None of this group developed haemorrhagic complications secondary to defibrotide. These observations suggest that prophylaxis with defibrotide alone may reduce the incidence of VOD post-SCT although a randomised controlled trial is warranted to further evaluate its role.

Úvod

Czech Academy of Sciences Publication Activity Database

Wögerbauer, Michael

2012-01-01

Roč. 44, č. 2012 (2012), s. 7-10 ISSN 0231-5904 Institutional support: RVO:68378068 Keywords : Genetic Criticism * critique génétique * creative process * Hay, Louis * Grésillon, Almuth Subject RIV: AJ - Letters, Mass-media, Audiovision

Defibrotide for the treatment of veno-occlusive disease after liver transplantation.

Science.gov (United States)

Mor, E; Pappo, O; Bar-Nathan, N; Shaharabani, E; Shapira, Z; Tur-Kaspa, R; Ben-Ari, Z

2001-10-15

Veno-occlusive disease (VOD) after liver transplantation is associated with acute rejection and poor outcome. The use of antithrombotic and thrombolytic agents is limited by their toxicity. Defibrotide is a polydeoxyribonucleotide with thrombolytic and antithrombotic properties and no systemic anticoagulant effect. Defibrotide, 35-40 mg/kg/day, was administered intravenously for 21 days on a compassionate-use basis to two patients aged 66 and 49 years. VOD had developed 6 weeks and 4 months after orthotopic liver transplantation for hepatitis C and hepatitis B infection, respectively. VOD was diagnosed clinically by findings of weight gain (8.5% and 16%), ascites, jaundice (serum bilirubin 5.4 mg/dl and 21.7 mg/dl), and severe coagulopathy (in one patient), and histologically by the presence of hemorrhagic centrilobular necrosis and fibrous stenosis of the hepatic venules. One of the patients had received azathioprine as part of the immunosuppressive regimen. There was no evidence of acute cellular rejection histologically. After 3 weeks of defibrotide administration, the first patient showed complete clinical resolution of the VOD, and serum bilirubin level normalized. He is alive 6 months after transplantation. The second patient, treated at a later stage of disease, showed marked improvement in the coagulopathic state, but there was no resolution of the VOD. He died 2 months later of multiorgan failure due to Escherichia coli sepsis. Neither patient had side effects from the drug. Defibrotide is a promising drug for the treatment of VOD after liver transplantation and needs to be evaluated in large, prospective studies.

Defibrotide for the treatment of sinusoidal obstruction syndrome: evaluation of response to therapy and patient outcomes.

Science.gov (United States)

Coutsouvelis, John; Avery, Sharon; Dooley, Michael; Kirkpatrick, Carl; Spencer, Andrew

2018-03-01

Defibrotide is an agent used to treat sinusoidal obstruction syndrome (SOS/VOD) in patients undergoing haemopoietic stem cell transplantation. The aim of this study was to evaluate the effectiveness of defibrotide used within institutional guidelines for the treatment of SOS/VOD in patients undergoing haemopoietic stem cell transplantation (HSCT). Data for 23 patients was retrospectively reviewed to evaluate the effectiveness of defibrotide and the utility of response criteria to direct therapy as specified within institution guidelines. Patients met institutional criteria for a diagnosis of SOS/VOD based on predominantly Baltimore criteria and received defibrotide. Stabilisation or improvement in symptoms and biochemical markers was required for continuation of therapy with defibrotide. Overall, 14 patients responded to therapy. Survival at day 100 post HSCT was 70%. Median serum (total) bilirubin concentrations in all evaluable patients had decreased at days 5 and 10 (p defibrotide, there was a decrease in the proportion of patients exhibiting hepatomegaly (p = 0.02), ascites (p Defibrotide to treat SOS/VOD and continued based on attainment of early response was effective management of this condition. Defibrotide should be considered in any consensus protocol providing guidance on the management of SOS/VOD, with future studies considered to assess appropriate time points for response to therapy during treatment.

Changing Climate and Overgrazing Are Decimating Mongolian Steppes

KAUST Repository

Liu, Yi Y.; Evans, Jason P.; McCabe, Matthew; de Jeu, Richard A. M.; van Dijk, Albert I. J. M.; Dolman, Albertus J.; Saizen, Izuru

2013-01-01

Satellite observations identify the Mongolian steppes as a hotspot of global biomass reduction, the extent of which is comparable with tropical rainforest deforestation. To conserve or restore these grasslands, the relative contributions of climate and human activities to degradation need to be understood. Here we use a recently developed 21-year (1988-2008) record of satellite based vegetation optical depth (VOD, a proxy for vegetation water content and aboveground biomass), to show that nearly all steppe grasslands in Mongolia experienced significant decreases in VOD. Approximately 60% of the VOD declines can be directly explained by variations in rainfall and surface temperature. After removing these climate induced influences, a significant decreasing trend still persists in the VOD residuals across regions of Mongolia. Correlations in spatial patterns and temporal trends suggest that a marked increase in goat density with associated grazing pressures and wild fires are the most likely non-climatic factors behind grassland degradation. © 2013 Liu et al.

Changing climate and overgrazing are decimating Mongolian steppes.

Directory of Open Access Journals (Sweden)

Yi Y Liu

Full Text Available Satellite observations identify the Mongolian steppes as a hotspot of global biomass reduction, the extent of which is comparable with tropical rainforest deforestation. To conserve or restore these grasslands, the relative contributions of climate and human activities to degradation need to be understood. Here we use a recently developed 21-year (1988-2008 record of satellite based vegetation optical depth (VOD, a proxy for vegetation water content and aboveground biomass, to show that nearly all steppe grasslands in Mongolia experienced significant decreases in VOD. Approximately 60% of the VOD declines can be directly explained by variations in rainfall and surface temperature. After removing these climate induced influences, a significant decreasing trend still persists in the VOD residuals across regions of Mongolia. Correlations in spatial patterns and temporal trends suggest that a marked increase in goat density with associated grazing pressures and wild fires are the most likely non-climatic factors behind grassland degradation.

Changing Climate and Overgrazing Are Decimating Mongolian Steppes

KAUST Repository

Liu, Yi Y.

2013-02-25

Satellite observations identify the Mongolian steppes as a hotspot of global biomass reduction, the extent of which is comparable with tropical rainforest deforestation. To conserve or restore these grasslands, the relative contributions of climate and human activities to degradation need to be understood. Here we use a recently developed 21-year (1988-2008) record of satellite based vegetation optical depth (VOD, a proxy for vegetation water content and aboveground biomass), to show that nearly all steppe grasslands in Mongolia experienced significant decreases in VOD. Approximately 60% of the VOD declines can be directly explained by variations in rainfall and surface temperature. After removing these climate induced influences, a significant decreasing trend still persists in the VOD residuals across regions of Mongolia. Correlations in spatial patterns and temporal trends suggest that a marked increase in goat density with associated grazing pressures and wild fires are the most likely non-climatic factors behind grassland degradation. © 2013 Liu et al.

Defibrotide for Patients with Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome: Interim Results from a Treatment IND Study.

Science.gov (United States)

Richardson, Paul G; Smith, Angela R; Triplett, Brandon M; Kernan, Nancy A; Grupp, Stephan A; Antin, Joseph H; Lehmann, Leslie; Shore, Tsiporah; Iacobelli, Massimo; Miloslavsky, Maja; Hume, Robin; Hannah, Alison L; Nejadnik, Bijan; Soiffer, Robert J

2017-06-01

Hepatic veno-occlusive disease, or sinusoidal obstruction syndrome (VOD/SOS), is a serious and potentially fatal complication of conditioning for hematopoietic stem cell transplantation (HSCT) or of chemotherapy regimens alone. Defibrotide is a complex mixture of single-stranded polydeoxyribonucleotides that is approved in the United States for treating hepatic VOD/SOS with renal or pulmonary dysfunction post-HSCT and in the European Union, Israel, and South Korea for treating severe hepatic VOD/SOS post-HSCT. Defibrotide was previously available in the United States as an investigational drug through a treatment protocol (treatment IND) study. Interim results of that large, treatment IND study of patients with VOD/SOS and with or without multiorgan dysfunction (MOD; also known as multiorgan failure) are presented here. Defibrotide was administered i.v. at 6.25 mg/kg every 6 hours (25 mg/kg/day), with a recommended treatment duration of at least 21 days. Enrolled patients (n = 681) were diagnosed with VOD/SOS based on Baltimore or modified Seattle criteria or liver biopsy analysis. Among the 573 HSCT recipients, 288 (50.3%; 95% confidence interval [CI], 46.2% to 54.4%) were alive at day +100 post-HSCT. Day +100 survival for the pediatric (≤16 years) and adult (>16 years) subgroups was 54.5% (95% CI, 49.1% to 60.0%; n = 174 of 319) and 44.9% (95% CI, 38.8% to 51.0%; n = 114 of 254), respectively. In the MOD subgroup, 159 of 351 patients (45.3%; 95% CI, 40.1% to 50.5%) of patients were alive at day +100 post-HSCT. Treatment with defibrotide was generally well tolerated, and drug-related toxicities were consistent with previous studies. Adverse events were reported in 69.6% of safety-evaluable patients (399 of 573). Other than VOD/SOS and associated MOD symptoms, the most commonly reported treatment-emergent adverse event was hypotension (13.8%). Day +100 survival results observed in this trial were consistent with results seen in previous trials of

Analytical Model for Mesh-based P2PVoD

NARCIS (Netherlands)

Lu, Y.; Mol, J.D.D.; Kuipers, F.A.; Van Mieghem, P.

Recently, there has been a growing interest in academic and commercial environments for Video-on-Demand (VoD) using Peer-to-Peer (P2P) technology. Unlike centralized solutions for VoD services, P2P technology lets the clients distribute video content among themselves. In this paper, we propose an

Escalation to High Dose Defibrotide in Patients with Hepatic Veno-Occlusive Disease

Science.gov (United States)

Triplett, Brandon M.; Kuttab, Hani I.; Kang, Guolian; Leung, Wing

2015-01-01

Hepatic veno-occlusive disease (VOD) is a serious complication of high-dose chemotherapy regimens, such as those utilized in hematopoietic cell transplantation recipients. Defibrotide is considered a safe and effective treatment when dosed at 25 mg/kg/day. However, patients who develop VOD still have increased mortality despite the use of defibrotide. Data are limited on the use of doses above 60 mg/kg/day for persistent VOD. In this prospective clinical trial, 34 patients received escalating doses of defibrotide. For patients with persistent VOD despite doses of 60 mg/kg/day, doses were increased to a maximum of 110 mg/kg/day. There was no observed increase in toxicity until doses rose beyond 100 mg/kg/day. Patients receiving doses between 10–100 mg/kg/day experienced an average of 3 bleeding episodes per 100 days of treatment, while those receiving doses >100 mg/kg/day experienced 13.2 bleeding episodes per 100 days (p=0.008). Moreover, dose reductions due to toxicity were needed at doses of 110 mg/kg/day more often than at lower doses. Defibrotide may be safely escalated to doses well above the current standard without an increase in bleeding risk. However, the efficacy of this dose escalation strategy remains unclear, as outcomes were similar to published cohorts of patients receiving standard doses of defibrotide for VOD. PMID:26278046

Demand forecasts at national and EU level on a computer-based model taking usage costs into account

DEFF Research Database (Denmark)

Passamonti, Lucia; Falch, Morten; Björksten, Margareta

1997-01-01

The objective of this deliverable is to forecast the residential spending on selected multimedia services such as Tele-entertainment, VOD, AOD, Networked games, Teleshopping and Teleworking.......The objective of this deliverable is to forecast the residential spending on selected multimedia services such as Tele-entertainment, VOD, AOD, Networked games, Teleshopping and Teleworking....

CT imaging of hepatic veno-occlusive disease (an analysis 14 cases)

International Nuclear Information System (INIS)

Zhang Guohua; Kong Azhao; Fang Junwei; Chen Yuejing; Zheng Weiliang; Dong Danjun; Zhang Shizheng

2006-01-01

Objective: To probe imaging characteristics of the hepatic veno-occlusive disease (VOD) based on clinical features and abdomen CT findings. Methods: Fourteen patients including 6 male and 8 female aged from 41 to 73 years were enrolled in this study. They all had previous trauma history and notoginseng was given as herbal remedy. Dynamic enhanced CT and color Dopplor ultrasound examinations were routinely used. Two of them received venous angiography and four cases were pathologically proved as VOD after CT guided needle biopsy. Results: Hepatic swelling and ascites were found on plain CT scan. Diffuse patchy areas without enhancement indicative of poorly hepatic perfusion were found. Hepatic veins were compressed and became thin, and inferior vena cava was flat and narrow without distal dilation or collateral circulation. No obstruction of hepatic veins and inferior vena cava was found on ultrasound and venography. Conclusion: Dynamic enhanced CT is highly valuable for early assessing VOD and imaging features of venous hepatic congestion found on CT was strongly suggestive of VOD if there's previous history of treatment of gynura segetum. (authors)

Escalation to High-Dose Defibrotide in Patients with Hepatic Veno-Occlusive Disease.

Science.gov (United States)

Triplett, Brandon M; Kuttab, Hani I; Kang, Guolian; Leung, Wing

2015-12-01

Hepatic veno-occlusive disease (VOD) is a serious complication of high-dose chemotherapy regimens, such as those used in hematopoietic cell transplantation recipients. Defibrotide is considered a safe and effective treatment when dosed at 25 mg/kg/day. However, patients who develop VOD still have increased mortality despite the use of defibrotide. Data are limited on the use of doses above 60 mg/kg/day for persistent VOD. In this prospective clinical trial 34 patients received escalating doses of defibrotide. For patients with persistent VOD despite doses of 60 mg/kg/day, doses were increased to a maximum of 110 mg/kg/day. Increased toxicity was not observed until doses rose beyond 100 mg/kg/day. Patients receiving doses between 10 and 100 mg/kg/day experienced an average of 3 bleeding episodes per 100 days of treatment, whereas those receiving doses >100 mg/kg/day experienced 13.2 bleeding episodes per 100 days (P = .008). Moreover, dose reductions due to toxicity were needed at doses of 110 mg/kg/day more often than at lower doses. Defibrotide may be safely escalated to doses well above the current standard without an increase in bleeding risk. However, the efficacy of this dose-escalation strategy remains unclear, because outcomes were similar to published cohorts of patients receiving standard doses of defibrotide for VOD. Copyright © 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

PRZEBIEG SYMULACJI KOMPUTEROWEJ PROCESU OCZYSZCZANIA SCIEKÓW KOMUNALNYCH W REAKTORZE OSADU CZYNNEGO

OpenAIRE

Zbigniew KOWALEWSKI; Elena NEVEROVA-DZIOPAK

2016-01-01

Celem badań było ustalenie wpływu ilości i zakresu parametrów jakości ścieków surowych na wiarygodność wyników symulacji, co umożliwiłoby ustalenie optymalnej częstotliwości ich monitoringu, niezbędnego do pozyskiwania danych do modelowania w programach ASM. W artykule przedstawiono metodykę prowadzenia symulacji komputerowej procesu oczyszczania ścieków komunalnych w reaktorach biologicznych z osadem czynnym. Zaprezentowano sposób przygotowania i przetwarzania danych wejściowych do modelu or...

Video-on-demand network design and maintenance using fuzzy optimization.

Science.gov (United States)

Abadpour, Arash; Alfa, Attahiru Sule; Diamond, Jeff

2008-04-01

Video-on-demand (VoD) is the entertainment source that, in the future, will likely overtake regular television in many aspects. Although many companies have deployed working VoD services, some aspects of the VoD should still undergo further improvement in order for it to reach to the foreseen potentials. An important aspect of a VoD system is the underlying network in which it operates. According to the huge number of customers in this network, it should be carefully designed to fulfill certain performance criteria. This process should be capable of finding optimal locations for the nodes of the network as well as determining the content that should be cached in each one. While this problem is categorized in the general group of network optimization problems, its specific characteristics demand a new solution to be sought for it. In this paper, which is inspired by the successful use of fuzzy optimization in similar problems in other fields, a fuzzy objective function that is heuristically shown to minimize the communication cost in a VoD network is derived while also controlling the storage cost. Then, an iterative algorithm is proposed to find a locally optimal solution to the proposed objective function. Capitalizing on the unrepeatable tendency of the proposed algorithm, a heuristic method for picking a good solution from a bundle of solutions produced by the proposed algorithm is also suggested. This paper includes a formal statement of the problem and its mathematical analysis. In addition, different scenarios in which the proposed algorithm can be utilized are discussed.

Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial.

Science.gov (United States)

Richardson, Paul G; Soiffer, Robert J; Antin, Joseph H; Uno, Hajime; Jin, Zhezhen; Kurtzberg, Joanne; Martin, Paul L; Steinbach, Gideon; Murray, Karen F; Vogelsang, Georgia B; Chen, Allen R; Krishnan, Amrita; Kernan, Nancy A; Avigan, David E; Spitzer, Thomas R; Shulman, Howard M; Di Salvo, Donald N; Revta, Carolyn; Warren, Diane; Momtaz, Parisa; Bradwin, Gary; Wei, L J; Iacobelli, Massimo; McDonald, George B; Guinan, Eva C

2010-07-01

Therapeutic options for severe hepatic veno-occlusive disease (VOD) are limited and outcomes are dismal, but early phase I/II studies have suggested promising activity and acceptable toxicity using the novel polydisperse oligonucleotide defibrotide. This randomized phase II dose-finding trial determined the efficacy of defibrotide in patients with severe VOD following hematopoietic stem cell transplantation (HSCT) and identified an appropriate dose for future trials. Adult and pediatric patients received either lower-dose (arm A: 25 mg/kg/day; n = 75) or higher-dose (arm B: 40 mg/kg/day; n = 74) i.v. defibrotide administered in divided doses every 6 hours for > or =14 days or until complete response, VOD progression, or any unacceptable toxicity occurred. Overall complete response and day +100 post-HSCT survival rates were 46% and 42%, respectively, with no significant difference between treatment arms. The incidence of treatment-related adverse events was low (8% overall; 7% in arm A, 10% in arm B); there was no significant difference in the overall rate of adverse events between treatment arms. Early stabilization or decreased bilirubin was associated with better response and day +100 survival, and decreased plasminogen activator inhibitor type 1 (PAI-1) during treatment was associated with better outcome; changes were similar in both treatment arms. Defibrotide 25 or 40 mg/kg/day also appears effective in treating severe VOD following HSCT. In the absence of any differences in activity, toxicity or changes in PAI-1 level, defibrotide 25 mg/kg/day was selected for ongoing phase III trials in VOD.

Defibrotide: An Oligonucleotide for Sinusoidal Obstruction Syndrome.

Science.gov (United States)

Aziz, May T; Kakadiya, Payal P; Kush, Samantha M; Weigel, Kylie; Lowe, Denise K

2018-02-01

To review the efficacy and safety of defibrotide as well as its pharmacology, mechanism of action, pharmacokinetics (PK), drug-drug interactions, dosing, cost considerations, and place in therapy. A PubMed search was performed through August 2017 using the terms defibrotide, oligonucleotide, hepatic veno-occlusive disease (VOD), sinusoidal obstruction syndrome (SOS), and hematopoietic cell transplantation (HCT). Other data sources were from references of identified studies, review articles, and conference abstracts plus manufacturer product labeling and website, the Food and Drug Administration website, and clinicaltrials.gov. English-language trials that examined defibrotide's pharmacodynamics, mechanism, PK, efficacy, safety, dosing, and cost-effectiveness were included. Trials have confirmed the safety and efficacy of defibrotide for treatment of VOD/SOS in adult and pediatric HCT patients, with complete response rates and day +100 overall survival rates ranging from 25.5% to 76% and 35% to 64%, respectively. The British Committee for Standards in Haematology/British Society for Blood and Marrow Transplantation Guidelines recommend defibrotide prophylaxis in pediatric and adult HCT patients with risk factors for VOD/SOS; however, its prophylactic use in the United States is controversial. Although there are efficacy data to support this strategy, cost-effectiveness data have not shown it to be cost-effective. Defibrotide has manageable toxicities, with low rates of grade 3 to 4 adverse effects. Defibrotide is the first medication approved in the United States for the treatment of adults and children with hepatic VOD/SOS, with renal or pulmonary dysfunction following HCT. Data evaluating defibrotide for VOD/SOS prevention are conflicting and have not shown cost-effectiveness.

Final results from a defibrotide treatment-IND study for patients with hepatic veno-occlusive disease/sinusoidal obstruction syndrome.

Science.gov (United States)

Kernan, Nancy A; Grupp, Stephan; Smith, Angela R; Arai, Sally; Triplett, Brandon; Antin, Joseph H; Lehmann, Leslie; Shore, Tsiporah; Ho, Vincent T; Bunin, Nancy; Iacobelli, Massimo; Liang, Wei; Hume, Robin; Tappe, William; Soiffer, Robert; Richardson, Paul

2018-05-16

Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially life-threatening complication of haematopoietic stem cell transplant (HSCT) conditioning and chemotherapy. Defibrotide is approved for treatment of hepatic VOD/SOS with pulmonary or renal dysfunction [i.e., multi-organ dysfunction (MOD)] after HSCT in the United States and severe VOD/SOS after HSCT in patients aged older than 1 month in the European Union. Defibrotide was available as an investigational drug by an expanded-access treatment programme (T-IND; NCT00628498). In the completed T-IND, the Kaplan-Meier estimated Day +100 survival for 1000 patients with documented defibrotide treatment after HSCT was 58·9% [95% confidence interval (CI), 55·7-61·9%]. Day +100 survival was also analysed by age and MOD status, and post hoc analyses were performed to determine Day +100 survival by transplant type, timing of VOD/SOS onset (≤21 or >21 days) and timing of defibrotide treatment initiation after VOD/SOS diagnosis. Day +100 survival in paediatric patients was 67·9% (95% CI, 63·8-71·6%) and 47·1% (95% CI, 42·3-51·8%) in adults. All patient subgroups without MOD had higher Day +100 survival than those with MOD; earlier defibrotide initiation was also associated with higher Day +100 survival. The safety profile of defibrotide in the completed T-IND study was similar to previous reports. © 2018 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd.

Enhanced canopy growth precedes senescence in 2005 and 2010 Amazonian droughts

KAUST Repository

Liu, Yi Y.

2018-04-09

Unprecedented droughts hit southern Amazonia in 2005 and 2010, causing a sharp increase in tree mortality and carbon loss. To better predict the rainforest\\'s response to future droughts, it is necessary to understand its behavior during past events. Satellite observations provide a practical source of continuous observations of Amazonian forest. Here we used a passive microwave-based vegetation water content record (i.e., vegetation optical depth, VOD), together with multiple hydrometeorological observations as well as conventional satellite vegetation measures, to investigate the rainforest canopy dynamics during the 2005 and 2010 droughts. During the onset of droughts in the wet-to-dry season (May–July) of both years, we found large-scale positive anomalies in VOD, leaf area index (LAI) and enhanced vegetation index (EVI) over the southern Amazonia. These observations are very likely caused by enhanced canopy growth. Concurrent below-average rainfall and above-average radiation during the wet-to-dry season can be interpreted as an early arrival of normal dry season conditions, leading to enhanced new leaf development and ecosystem photosynthesis, as supported by field observations. Our results suggest that further rainfall deficit into the subsequent dry season caused water and heat stress during the peak of 2005 and 2010 droughts (August–October) that exceeded the tolerance limits of the rainforest, leading to widespread negative VOD anomalies over the southern Amazonia. Significant VOD anomalies were observed mainly over the western part in 2005 and mainly over central and eastern parts in 2010. The total area with significant negative VOD anomalies was comparable between these two drought years, though the average magnitude of significant negative VOD anomalies was greater in 2005. This finding broadly agrees with the field observations indicating that the reduction in biomass carbon uptake was stronger in 2005 than 2010. The enhanced canopy growth

Enhanced canopy growth precedes senescence in 2005 and 2010 Amazonian droughts

KAUST Repository

Liu, Yi Y.; van Dijk, Albert I.J.M.; Miralles, Diego G.; McCabe, Matthew; Evans, Jason P.; de Jeu, Richard A.M.; Gentine, Pierre; Huete, Alfredo; Parinussa, Robert M.; Wang, Lixin; Guan, Kaiyu; Berry, Joe; Restrepo-Coupe, Natalia

2018-01-01

Unprecedented droughts hit southern Amazonia in 2005 and 2010, causing a sharp increase in tree mortality and carbon loss. To better predict the rainforest's response to future droughts, it is necessary to understand its behavior during past events. Satellite observations provide a practical source of continuous observations of Amazonian forest. Here we used a passive microwave-based vegetation water content record (i.e., vegetation optical depth, VOD), together with multiple hydrometeorological observations as well as conventional satellite vegetation measures, to investigate the rainforest canopy dynamics during the 2005 and 2010 droughts. During the onset of droughts in the wet-to-dry season (May–July) of both years, we found large-scale positive anomalies in VOD, leaf area index (LAI) and enhanced vegetation index (EVI) over the southern Amazonia. These observations are very likely caused by enhanced canopy growth. Concurrent below-average rainfall and above-average radiation during the wet-to-dry season can be interpreted as an early arrival of normal dry season conditions, leading to enhanced new leaf development and ecosystem photosynthesis, as supported by field observations. Our results suggest that further rainfall deficit into the subsequent dry season caused water and heat stress during the peak of 2005 and 2010 droughts (August–October) that exceeded the tolerance limits of the rainforest, leading to widespread negative VOD anomalies over the southern Amazonia. Significant VOD anomalies were observed mainly over the western part in 2005 and mainly over central and eastern parts in 2010. The total area with significant negative VOD anomalies was comparable between these two drought years, though the average magnitude of significant negative VOD anomalies was greater in 2005. This finding broadly agrees with the field observations indicating that the reduction in biomass carbon uptake was stronger in 2005 than 2010. The enhanced canopy growth

Defibrotide for the Treatment of Hepatic Veno-Occlusive Disease: Final Results From the International Compassionate-Use Program.

Science.gov (United States)

Corbacioglu, Selim; Carreras, Enric; Mohty, Mohamad; Pagliuca, Antonio; Boelens, Jaap Jan; Damaj, Gandhi; Iacobelli, Massimo; Niederwieser, Dietger; Olavarría, Eduardo; Suarez, Felipe; Ruutu, Tapani; Verdonck, Leo; Hume, Robin; Nejadnik, Bijan; Lai, Chinglin; Finetto, Giorgia; Richardson, Paul

2016-10-01

Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is an unpredictable and potentially fatal complication of hematopoietic cell transplantation (HCT) or nontransplantation-associated chemotherapy/radiotherapy. In cases of severe hepatic VOD/SOS, typically defined by associated multiorgan failure (MOF, also known as multiorgan dysfunction), mortality exceeds 80%. Preclinical and early clinical data have provided a rationale for defibrotide treatment in hepatic VOD/SOS. Based on this evidence and in recognition of the dismal prognosis for these patients, defibrotide was made available through an international multicenter compassionate-use program conducted from December 1998 to March 2009. Physicians participating in the program voluntarily provided demographic and outcome data for patients given defibrotide. Efficacy and safety analyses were performed using the data received for 710 treated patients. Defibrotide was given at 10, 25, 40, 60, or 80 mg/kg/day for a median of 15 days (range, 1 to 119 days). By Kaplan-Meier analysis, the estimated overall day +100 survival was 54% (58% in the 25 mg/kg/day dose group). Adverse events (AEs) were reported in 53% of patients. The most common AEs were MOF, progression of hepatic VOD/SOS, sepsis, and graft-versus-host disease, which were consistent with the AEs expected for this patient population. No clinically meaningful trends in AEs were identified by gender, age, or dose group. Safety and efficacy resultswere consistent with prior studies of defibrotide in hepatic VOD/SOS, and subgroup analyses lend support to the use of the 25 mg/kg/day dose. Copyright © 2016 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Designing a scalable video-on-demand server with data sharing

Science.gov (United States)

Lim, Hyeran; Du, David H. C.

2001-01-01

As current disk space and transfer speed increase, the bandwidth between a server and its disks has become critical for video-on-demand (VOD) services. Our VOD server consists of several hosts sharing data on disks through a ring-based network. Data sharing provided by the spatial-reuse ring network between servers and disks not only increases the utilization towards full bandwidth but also improves the availability of videos. Striping and replication methods are introduced in order to improve the efficiency of our VOD server system as well as the availability of videos. We consider tow kinds of resources of a VOD server system. Given a representative access profile, our intention is to propose an algorithm to find an initial condition, place videos on disks in the system successfully. If any copy of a video cannot be placed due to lack of resources, more servers/disks are added. When all videos are place on the disks by our algorithm, the final configuration is determined with indicator of how tolerable it is against the fluctuation in demand of videos. Considering it is a NP-hard problem, our algorithm generates the final configuration with O(M log M) at best, where M is the number of movies.

The Effect of Signal Quality and Contiguous Word of Mouth on Customer Acquisition for a Video-on-Demand Service

OpenAIRE

Sungjoon Nam; Puneet Manchanda; Pradeep K. Chintagunta

2010-01-01

This paper documents the existence and magnitude of contiguous word-of-mouth effects of signal quality of a video-on-demand (VOD) service on customer acquisition. We operationalize contiguous word-of-mouth effect based on geographic proximity and use behavioral data to quantify the effect. The signal quality for this VOD service is exogenously determined, objectively measured, and spatially uncorrelated. Furthermore, it is unobserved to the potential subscriber and is revealed postadoption. F...

Initializing carbon cycle predictions from the Community Land Model by assimilating global biomass observations

Science.gov (United States)

Fox, A. M.; Hoar, T. J.; Smith, W. K.; Moore, D. J.

2017-12-01

The locations and longevity of terrestrial carbon sinks remain uncertain, however it is clear that in order to predict long-term climate changes the role of the biosphere in surface energy and carbon balance must be understood and incorporated into earth system models (ESMs). Aboveground biomass, the amount of carbon stored in vegetation, is a key component of the terrestrial carbon cycle, representing the balance of uptake through gross primary productivity (GPP), losses from respiration, senescence and mortality over hundreds of years. The best predictions of current and future land-atmosphere fluxes are likely from the integration of process-based knowledge contained in models and information from observations of changes in carbon stocks using data assimilation (DA). By exploiting long times series, it is possible to accurately detect variability and change in carbon cycle dynamics through monitoring ecosystem states, for example biomass derived from vegetation optical depth (VOD), and use this information to initialize models before making predictions. To make maximum use of information about the current state of global ecosystems when using models we have developed a system that combines the Community Land Model (CLM) with the Data Assimilation Research Testbed (DART), a community tool for ensemble DA. This DA system is highly innovative in its complexity, completeness and capabilities. Here we described a series of activities, using both Observation System Simulation Experiments (OSSEs) and real observations, that have allowed us to quantify the potential impact of assimilating VOD data into CLM-DART on future land-atmosphere fluxes. VOD data are particularly suitable to use in this activity due to their long temporal coverage and appropriate scale when combined with CLM, but their absolute values rely on many assumptions. Therefore, we have had to assess the implications of the VOD retrieval algorithms, with an emphasis on detecting uncertainty due to

Window-Based Popularity Caching for IPTV On-Demand Services

OpenAIRE

Hsuan Chiu; Chi-He Chang; Chao-Wei Tseng; Chi-Shi Liu

2011-01-01

In recent years, many telecommunication companies have regarded IP network as a new delivery platform for providing TV services because IP network is equipped with two-way and high-speed communication abilities which are appropriate to provide on-demand services and linear TV programs. However, in this IPTV system, the requests of VOD (video on demand) are usually aggregated in a short period intensively and user preferences are fluctuated dynamically. Moreover, the VOD content is updated fre...

Global changes in dryland vegetation dynamics (1988–2008 assessed by satellite remote sensing: comparing a new passive microwave vegetation density record with reflective greenness data

Directory of Open Access Journals (Sweden)

N. Andela

2013-10-01

Full Text Available Drylands, covering nearly 30% of the global land surface, are characterized by high climate variability and sensitivity to land management. Here, two satellite-observed vegetation products were used to study the long-term (1988–2008 vegetation changes of global drylands: the widely used reflective-based Normalized Difference Vegetation Index (NDVI and the recently developed passive-microwave-based Vegetation Optical Depth (VOD. The NDVI is sensitive to the chlorophyll concentrations in the canopy and the canopy cover fraction, while the VOD is sensitive to vegetation water content of both leafy and woody components. Therefore it can be expected that using both products helps to better characterize vegetation dynamics, particularly over regions with mixed herbaceous and woody vegetation. Linear regression analysis was performed between antecedent precipitation and observed NDVI and VOD independently to distinguish the contribution of climatic and non-climatic drivers in vegetation variations. Where possible, the contributions of fire, grazing, agriculture and CO2 level to vegetation trends were assessed. The results suggest that NDVI is more sensitive to fluctuations in herbaceous vegetation, which primarily uses shallow soil water, whereas VOD is more sensitive to woody vegetation, which additionally can exploit deeper water stores. Globally, evidence is found for woody encroachment over drylands. In the arid drylands, woody encroachment appears to be at the expense of herbaceous vegetation and a global driver is interpreted. Trends in semi-arid drylands vary widely between regions, suggesting that local rather than global drivers caused most of the vegetation response. In savannas, besides precipitation, fire regime plays an important role in shaping trends. Our results demonstrate that NDVI and VOD provide complementary information and allow new insights into dryland vegetation dynamics.

Application of Ozonation to Intensify Nitrification and Denitrification Processes/ Využití Ozonizace K Intenzifikaci Nitrifikačních A Denitrifikačních Procesů

Directory of Open Access Journals (Sweden)

Drozdová Martina

2014-10-01

Full Text Available Dusík a fosfor patří mezi nejdůležitější makrobiogenní prvky, které jsou nezbytné pro rozvoj mikroorganismů. Významným zdrojem organických i anorganických sloučenin dusíku ve vodách jsou splaškové odpadní vody a průmyslové odpadní vody z výroby dusíkatých látek. V povrchové vodě se většina amoniaku nachází ve formě amonných kationtů, NH4+. Tohoto poznatku lze využít v procesu čištění odpadních vod. Článek je zaměřen na možné využití procesu ozonizace při úpravě a čištění vod znečištěných nadměrným množstvím organických látek obsahujících zejména dusík dusíkatých látek a jeho následné aplikaci v kombinaci s jinými oxidačními procesy (AOP.

Sorption of phenanthrene and benzene on differently structural kerogen: important role of micropore-filling.

Science.gov (United States)

Zhang, Yulong; Ma, Xiaoxuan; Ran, Yong

2014-02-01

Shale was thermally treated to obtain a series of kerogen with varied maturation. Their chemical, structural and porous properties were related to the sorption and/or desorption behaviors of phenanthrene and benzene. As the treatment temperature increases, aliphatic and carbonyl carbon of the kerogen samples decrease, while their aromaticity and maturation increase. Meanwhile, the isothermal nonlinearity of phenanthrene and benzene increases whereas the sorption capacity and micropore adsorption volumes (Vo,d) initially increase and then decrease. The Vo,d of benzene is significantly correlated with, but higher than that of phenanthrene, suggesting similar micropore filling mechanism and molecular sieve effect. The benzene desorption exhibits hysteresis, which is related to the pore deformation of the kerogen and the entrapment of solute in the kerogen matrix. The Vo,d of phenanthrene and benzene on the kerogen samples accounts for 23-46% and 36-65% of the maximum sorption volumes, respectively, displaying the importance of the micropore filling. Copyright © 2013 Elsevier Ltd. All rights reserved.

Consensus Report by the Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplantation Consortium Joint Working Committees on Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents, Part 3: Focus on Cardiorespiratory Dysfunction, Infections, Liver Dysfunction, and Delirium.

Science.gov (United States)

Ovchinsky, Nadia; Frazier, Warren; Auletta, Jeffery J; Dvorak, Christopher C; Ardura, Monica; Song, Enkyung; McArthur, Jennifer; Jeyapalan, Asumthia; Tamburro, Robert; Mahadeo, Kris M; Traube, Chani; Duncan, Christine N; Bajwa, Rajinder P S

2018-02-01

Some patients with veno-occlusive disease (VOD) have multiorgan dysfunction, and multiple teams are involved in their daily care in the pediatric intensive care unit. Cardiorespiratory dysfunction is critical in these patients, requiring immediate action. The decision of whether to use a noninvasive or an invasive ventilation strategy may be difficult in the setting of mucositis or other comorbidities in patients with VOD. Similarly, monitoring of organ functions may be very challenging in these patients, who may have fulminant hepatic failure with or without hepatic encephalopathy complicated by delirium and/or infections. In this final guideline of our series on supportive care in patients with VOD, we address some of these questions and provide evidence-based recommendations on behalf of the Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplantation Consortium Joint Working Committees. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

A PHOTOMETRIC METALLICITY ESTIMATE OF THE VIRGO STELLAR OVERDENSITY

International Nuclear Information System (INIS)

An, Deokkeun; Johnson, Jennifer A.; Pinsonneault, Marc H.; Terndrup, Donald M.; Masseron, Thomas; Beers, Timothy C.; Lee, Young Sun; Delahaye, Franck; Yanny, Brian

2009-01-01

We determine photometric metal abundance estimates for individual main-sequence stars in the Virgo Overdensity (VOD), which covers almost 1000 deg 2 on the sky, based on a calibration of the metallicity sensitivity of stellar isochrones in the gri filter passbands using field stars with well-determined spectroscopic metal abundances. Despite the low precision of the method for individual stars, we derive [Fe/H] = -2.0 ± 0.1(internal) ± 0.5(systematic) for the metal abundance of the VOD from photometric measurements of 0.7 million stars in the northern Galactic hemisphere with heliocentric distances from ∼10 kpc to ∼20 kpc. The metallicity of the VOD is indistinguishable, within Δ[Fe/H] ≤ 0.2, from that of field halo stars covering the same distance range. This initial application suggests that the Sloan Digital Sky Survey gri passbands can be used to probe the properties of main-sequence stars beyond ∼10 kpc, complementing studies of nearby stars from more metallicity-sensitive color indices that involve the u passband.

SMAP Multi-Temporal Soil Moisture and Vegetation Optical Depth Retrievals in Vegetated Regions Including Higher-Order Soil-Canopy Interactions

Science.gov (United States)

Feldman, A.; Akbar, R.; Konings, A. G.; Piles, M.; Entekhabi, D.

2017-12-01

The Soil Moisture Active Passive (SMAP) mission utilizes a zeroth order radiative transfer model, known as the tau-omega model, to retrieve soil moisture from microwave brightness temperature observations. This model neglects first order scattering which is significant at L-Band in vegetated regions, or 30% of land cover. Previous higher order algorithms require extensive in-situ measurements and characterization of canopy layer physical properties. We propose a first order retrieval algorithm that approximately characterizes the eight first order emission pathways using rough surface reflectivity, vegetation optical depth (VOD), and scattering albedo terms. The recently developed Multi-Temporal Dual Channel Algorithm (MT-DCA) then retrieves these three parameters in a forward model without ancillary information under the assumption of temporally static albedo and constant vegetation water content between three day SMAP revisits. The approximated scattering terms are determined to be conservative estimates of analytically derived first order scattering terms. In addition, we find the first order algorithm to be more sensitive to surface emission than the tau-omega model. The simultaneously retrieved VOD, previously demonstrated to be proportional to vegetation water content, can provide insight into vegetation dynamics in regions with significant phenology. Specifically, dry tropical forests exhibit an increase in VOD during the dry season in alignment with prior studies that suggest that certain vegetative species green up during the dry season despite limited water availability. VOD retrieved using the first order algorithm and MT-DCA framework can therefore contribute to understanding of tropical forests' role in the carbon, energy, and water cycles, which has yet to be fully explained.

Comparing land surface phenology derived from satellite and GPS network microwave remote sensing.

Science.gov (United States)

Jones, Matthew O; Kimball, John S; Small, Eric E; Larson, Kristine M

2014-08-01

The land surface phenology (LSP) start of season (SOS) metric signals the seasonal onset of vegetation activity, including canopy growth and associated increases in land-atmosphere water, energy and carbon (CO2) exchanges influencing weather and climate variability. The vegetation optical depth (VOD) parameter determined from satellite passive microwave remote sensing provides for global LSP monitoring that is sensitive to changes in vegetation canopy water content and biomass, and insensitive to atmosphere and solar illumination constraints. Direct field measures of canopy water content and biomass changes desired for LSP validation are generally lacking due to the prohibitive costs of maintaining regional monitoring networks. Alternatively, a normalized microwave reflectance index (NMRI) derived from GPS base station measurements is sensitive to daily vegetation water content changes and may provide for effective microwave LSP validation. We compared multiyear (2007-2011) NMRI and satellite VOD records at over 300 GPS sites in North America, and their derived SOS metrics for a subset of 24 homogenous land cover sites to investigate VOD and NMRI correspondence, and potential NMRI utility for LSP validation. Significant correlations (P<0.05) were found at 276 of 305 sites (90.5 %), with generally favorable correspondence in the resulting SOS metrics (r (2)=0.73, P<0.001, RMSE=36.8 days). This study is the first attempt to compare satellite microwave LSP metrics to a GPS network derived reflectance index and highlights both the utility and limitations of the NMRI data for LSP validation, including spatial scale discrepancies between local NMRI measurements and relatively coarse satellite VOD retrievals.

Land Surface Phenologies and Seasonalities of Croplands and Grasslands in the US Prairie Pothole Region Using Passive Microwave Data (2003-2015)

Science.gov (United States)

Alemu, W. G.; Henebry, G. M.

2017-12-01

Grasslands and wetlands in the Prairie Pothole Region (PPR) have been converted to croplands in recent years. Crops cultivated in the PPR are also changing: spring wheat and alfalfa/hay are being switched to corn and soybean due to biofuel demand. According to the USDA Cropland Data Layer (CDL) from 2003 to 2015, spring wheat significantly decreased (r2 = 0.74), while corn and soybeans significantly increased (r2 = 0.86). We characterized land surface phenologies and land surface seasonalities across the PPR using the finer temporal (twice daily) but much lower spatial (25 km) resolution Advanced Microwave Scanning Radiometer (AMSR: blended from AMSR-E and AMSR2) enhanced land surface parameters for 2003-2015 (DOY 91-330 annual cycles). We tracked the temporal development of these land surface parameters as a function of accumulated growing degree-days (AGDD) based on the AMSR retrieved air temperature data. Growing degree-days (GDD) revealed distinct seasonality typical to temperate grasslands and croplands. GDD peaks were 23°C and it peaks at 1700°C AGDD. Precipitable water vapor (V) displayed seasonality comparable to GDD. Vegetation optical depth (VOD) revealed distinct land surface phenologies for grasslands versus croplands. We explored the changing crop fractions within the 25 km AMSR pixels using the CDL. Crop-dominated sites VOD time series caught the early spring growth, ploughing, and crop growth dynamics. In contrast, the VOD time series at grass-dominated sites exhibited a lower but more extended amplitude throughout the non-frozen season. VODs peaked at 1.6 and 1.3 for croplands and grasslands, respectively. Croplands peaked about a month later than grasslands (2200 °C AGDD vs. 1600 °C AGDD). The other parameters available from the AMSR dataset—soil moisture (sm), and fractional open water (fw)—together with the AGDD time series constructed from the AMSR air temperature data revealed the passage of storm systems during the growing season. Soil

Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure.

Science.gov (United States)

Richardson, Paul G; Riches, Marcie L; Kernan, Nancy A; Brochstein, Joel A; Mineishi, Shin; Termuhlen, Amanda M; Arai, Sally; Grupp, Stephan A; Guinan, Eva C; Martin, Paul L; Steinbach, Gideon; Krishnan, Amrita; Nemecek, Eneida R; Giralt, Sergio; Rodriguez, Tulio; Duerst, Reggie; Doyle, John; Antin, Joseph H; Smith, Angela; Lehmann, Leslie; Champlin, Richard; Gillio, Alfred; Bajwa, Rajinder; D'Agostino, Ralph B; Massaro, Joseph; Warren, Diane; Miloslavsky, Maja; Hume, Robin L; Iacobelli, Massimo; Nejadnik, Bijan; Hannah, Alison L; Soiffer, Robert J

2016-03-31

Hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS), is a potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT). Untreated hepatic VOD/SOS with multi-organ failure (MOF) is associated with >80% mortality. Defibrotide has shown promising efficacy treating hepatic VOD/SOS with MOF in phase 2 studies. This phase 3 study investigated safety and efficacy of defibrotide in patients with established hepatic VOD/SOS and advanced MOF. Patients (n = 102) given defibrotide 25 mg/kg per day were compared with 32 historical controls identified out of 6867 medical charts of HSCT patients by blinded independent reviewers. Baseline characteristics between groups were well balanced. The primary endpoint was survival at day +100 post-HSCT; observed rates equaled 38.2% in the defibrotide group and 25% in the controls (23% estimated difference; 95.1% confidence interval [CI], 5.2-40.8;P= .0109, using a propensity-adjusted analysis). Observed day +100 complete response (CR) rates equaled 25.5% for defibrotide and 12.5% for controls (19% difference using similar methodology; 95.1% CI, 3.5-34.6;P= .0160). Defibrotide was generally well tolerated with manageable toxicity. Related adverse events (AEs) included hemorrhage or hypotension; incidence of common hemorrhagic AEs (including pulmonary alveolar [11.8% and 15.6%] and gastrointestinal bleeding [7.8% and 9.4%]) was similar between the defibrotide and control groups, respectively. Defibrotide was associated with significant improvement in day +100 survival and CR rate. The historical-control methodology offers a novel, meaningful approach for phase 3 evaluation of orphan diseases associated with high mortality. This trial was registered at www.clinicaltrials.gov as #. © 2016 by The American Society of Hematology.

Veno occlusive disease: Update on clinical management

Science.gov (United States)

Senzolo, M; Germani, G; Cholongitas, E; Burra, P; Burroughs, AK

2007-01-01

Hepatic veno-occlusive disease is a clinical syndrome characterized by hepatomegaly, ascites, weight gain and jaundice, due to sinusoidal congestion which can be caused by alkaloid ingestion, but the most frequent cause is haematopoietic stem cell transplantation (STC) and is also seen after solid organ transplantation. The incidence of veno occlusive disease (VOD) after STC ranges from 0 to 70%, but is decreasing. Survival is good when VOD is a mild form, but when it is severe and associated with an increase of hepatic venous pressure gradient > 20 mmHg, and mortality is about 90%. Prevention remains the best therapeutic strategy, by using non-myeloablative conditioning regimens before STC. Prophylactic administration of ursodeoxycholic acid, being an antioxidant and antiapoptotic agent, can have some benefit in reducing overall mortality. Defibrotide, which has pro-fibrinolytic and antithrombotic properties, is the most effective therapy; decompression of the sinusoids by a transjugular intrahepatic portosystemic shunt (TIPS) can be tried, especially to treat VOD after liver transplantation and when multiorgan failure (MOF) is not present. Liver transplantation can be the last option, but can not be considered a standard rescue therapy, because usually the concomitant presence of multiorgan failure contraindicates this procedure. PMID:17663504

Optimized ventilation-on-demand (VOD)

Energy Technology Data Exchange (ETDEWEB)

Masse, M. [Simsmart Technologies Inc., Brossard, PQ (Canada); Cervinka, A. [Newtrax Technologies Inc., Montreal, PQ (Canada)

2008-07-01

This presentation described how the combination of 2 innovative technologies can help optimize mine ventilation. Newtrax Technologies has developed a self-contained battery-powered wireless electronic system designed to operate in harsh industrial environments, including underground mines. Simsmart Technologies has created an advanced process and control simulation based design tool used in industrial applications, including mine ventilation systems. This presentation described the system components and how they work. These included the wireless mesh network designed for dynamic diesel machinery tracking and operating status monitoring; the real-time ventilation model and fan speed optimizer; the OPC server for information interchange; the OPC linkage to existing control infrastructure; a human machine interface that provide data archiving capability; live MS-Excel to interrogate the simulation, controls and optimizer; and, the battery-powered network mesh that provides SCADA functionality to route optimized setpoints. Details of the user interface were also provided. 1 tab., 20 figs.

Defibrotide in the treatment of hepatic veno-occlusive disease.

Science.gov (United States)

Fulgenzi, Alessandro; Ferrero, Maria Elena

2016-01-01

Hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), represents the most frequent complication in patients in early phase following hematopoietic stem-cell transplantation (HSCT). In its severe form, VOD/SOS can be associated with multiorgan failure and with a mortality rate >80% by day +100. Defibrotide (DF) (a mixture of 90% single-stranded phosphodiester oligonucleotides and 10% double-stranded phosphodiester oligonucleotides derived from controlled depolarization of porcine intestinal mucosal DNA) has been proposed for the treatment of SOS due to its ability to restore thrombo-fibrinolytic balance and protect endothelial cells. The present review highlights why the mechanisms of action of DF allow its successful use in the prevention and treatment of SOS following HSCT.

Spatial and temporal variability of biophysical variables in southwestern France from airborne L-band radiometry

Directory of Open Access Journals (Sweden)

E. Zakharova

2012-06-01

Full Text Available In 2009 and 2010 the L-band microwave Cooperative Airborne Radiometer for Ocean and Land Studies (CAROLS campaign was performed in southwestern France to support the calibration and validation of the new Soil Moisture and Ocean Salinity (SMOS satellite mission. The L-band Microwave Emission of the Biosphere (L-MEB model was used to retrieve surface soil moisture (SSM and the vegetation optical depth (VOD from the CAROLS brightness temperature measurements. The CAROLS SSM was compared with in situ observations at 11 sites of the SMOSMANIA (Soil Moisture Observing System-Meteorological Automatic Network Integrated Application network of Météo-France. For eight of them, significant correlations were observed (0.51 ≤ r ≤ 0.82, with standard deviation of differences ranging from 0.039 m³ m⁻³ to 0.141 m³ m⁻³. Also, the CAROLS SSM was compared with SSM values simulated by the A-gs version of the Interactions between Soil, Biosphere and Atmosphere (ISBA-A-gs model along 20 flight lines, at a resolution of 8 km × 8 km. A significant spatial correlation between these two datasets was observed for all the flights (0.36 ≤ r ≤ 0.85. The CAROLS VOD presented significant spatial correlations with the vegetation water content (VWC derived from the spatial distribution of vegetation types used in ISBA-A-gs and from the Leaf Area Index (LAI simulated for low vegetation. On the other hand, the CAROLS VOD presented little temporal changes, and no temporal correlation was observed with the simulated LAI. For low vegetation, the ratio of VOD to VWC tended to decrease, from springtime to summertime. The ISBA-A-gs grid cells (8 km × 8 km were sampled every 5 m by CAROLS observations, at a spatial resolution of about 2 km. For 83% of the grid cells, the standard deviation of the sub-grid CAROLS SSM was lower than 0.05 m³ m⁻³. The presence of small water bodies within the

Comparison of soil moisture retrieval algorithms based on the synergy between SMAP and SMOS-IC

Science.gov (United States)

Ebrahimi-Khusfi, Mohsen; Alavipanah, Seyed Kazem; Hamzeh, Saeid; Amiraslani, Farshad; Neysani Samany, Najmeh; Wigneron, Jean-Pierre

2018-05-01

This study was carried out to evaluate possible improvements of the soil moisture (SM) retrievals from the SMAP observations, based on the synergy between SMAP and SMOS. We assessed the impacts of the vegetation and soil roughness parameters on SM retrievals from SMAP observations. To do so, the effects of three key input parameters including the vegetation optical depth (VOD), effective scattering albedo (ω) and soil roughness (HR) parameters were assessed with the emphasis on the synergy with the VOD product derived from SMOS-IC, a new and simpler version of the SMOS algorithm, over two years of data (April 2015 to April 2017). First, a comprehensive comparison of seven SM retrieval algorithms was made to find the best one for SM retrievals from the SMAP observations. All results were evaluated against in situ measurements over 548 stations from the International Soil Moisture Network (ISMN) in terms of four statistical metrics: correlation coefficient (R), root mean square error (RMSE), bias and unbiased RMSE (UbRMSE). The comparison of seven SM retrieval algorithms showed that the dual channel algorithm based on the additional use of the SMOS-IC VOD product (selected algorithm) led to the best results of SM retrievals over 378, 399, 330 and 271 stations (out of a total of 548 stations) in terms of R, RMSE, UbRMSE and both R & UbRMSE, respectively. Moreover, comparing the measured and retrieved SM values showed that this synergy approach led to an increase in median R value from 0.6 to 0.65 and a decrease in median UbRMSE from 0.09 m3/m3 to 0.06 m3/m3. Second, using the algorithm selected in a first step and defined above, the ω and HR parameters were calibrated over 218 rather homogenous ISMN stations. 72 combinations of various values of ω and HR were used for the calibration over different land cover classes. In this calibration process, the optimal values of ω and HR were found for the different land cover classes. The obtained results indicated that the

Does defibrotide induce a delay to polymorphonuclear neutrophil engraftment after hematopoietic stem cell transplantation? Observation in a pediatric population.

Science.gov (United States)

Maximova, Natalia; Pizzol, Antonio; Giurici, Nagua; Granzotto, Marilena

2015-04-01

In recent years, defibrotide (DFT) has emerged as a promising therapy for veno-occlusive disease (VOD). The aim of this study was to investigate whether DFT prophylaxis affects neutrophil engraftment in patients undergoing hematopoietic stem cell transplantation (HSCT). A cohort of 44 consecutive pediatric patients who underwent HSCT was retrospectively analyzed to see the role of DFT on engraftment. Patients were assigned into two groups based on the use or non-use of prophylaxis with DFT. The mean time to engraftment was statistically different between the two groups for both polymorphonuclear neutrophils (PMN) and white blood cells. Our study supports the hypothesis that prophylaxis with DFT for VOD leads to a delay to the engraftment of PMN in pediatric patients that underwent HSCT.

Radiation monitoring of the Slovak Hydrometeorological Institute - Present and future

International Nuclear Information System (INIS)

Melicherova, T.

2008-01-01

Network for air radioactivity monitoring was developed in the frame Slovak Hydrometeorological Institute (SHMI) since 1963. There are data available for many years for beta radioactivity of the air particulate and deposition. At present network consist from 26 monitoring points for measurement of dose rate and 3 monitoring points for aerosol monitors. Measuring instrument are placed in the professional stations of the selected parts of Slovakia. They are regularly verified and calibrated in the Slovak Institute for Metrology. Radiation monitoring in the SHMI is one part of the Environmental monitoring of Slovakia. All activities and operation of this system are financed from governmental budget of the Environmental monitoring. All information about this system are available on the web page http://enviroportal.sk/ in the part 'Informacny system monitoringu'. (authors)

Radiation monitoring of the Slovak Hydrometeorological Institute - Present and future

International Nuclear Information System (INIS)

Melicherova, T.

2009-01-01

Network for air radioactivity monitoring was developed in the frame Slovak Hydrometeorological Institute (SHMI) since 1963. There are data available for many years for beta radioactivity of the air particulate and deposition. At present network consist from 26 monitoring points for measurement of dose rate and 3 monitoring points for aerosol monitors. Measuring instrument are placed in the professional stations of the selected parts of Slovakia. They are regularly verified and calibrated in the Slovak Institute for Metrology. Radiation monitoring in the SHMI is one part of the Environmental monitoring of Slovakia. All activities and operation of this system are financed from governmental budget of the Environmental monitoring. All information about this system are available on the web page http://enviroportal.sk/ in the part 'Informacny system monitoringu'. (authors)

Safety of peritoneal and pleural drain placement in pediatric stem cell transplant recipients with severe veno-occlusive disease.

Science.gov (United States)

Madenci, Arin L; Stetson, Alyssa; Weldon, Christopher B; Lehmann, Leslie E

2016-08-01

Hepatic VOD (veno-occlusive disease) is a serious complication of HSCT (hematopoietic stem cell transplantation) and has historically been associated with high mortality. This obstruction to hepatic flow often results in fluid collections in the peritoneal and pleural cavities. Catheter placement to drain ascites or pleural fluid may reduce intra-abdominal hypertension and/or improve respiratory parameters. The safety of these interventions among critically ill, immunocompromised children is unknown. Among 32 HSCT recipients (2000-2012) with severe VOD, we assessed the primary outcome of procedural complication from peritoneal drain placement. Twenty-four (75%) patients underwent peritoneal drain placement. No patient sustained visceral perforation or hemorrhage with drain placement. Overall mortality was 47% (n = 15). The procedure was not associated with increased overall mortality (p > 0.99). Eight (25%) peritoneal drains required replacement for malfunction. Of 24 patients with peritoneal drains, one (4%) patient had a positive culture from ascitic fluid. Eight (25%) patients underwent pleural drain placement. No pleural drain-related procedural complication or infection occurred. Four (50%) of the eight patients with pleural drains had de-escalation in oxygen requirement at drain removal, compared to time of placement. In this study, peritoneal and pleural drains were safe interventions for children with severe VOD. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Integration of satellite-induced fluorescence and vegetation optical depth to improve the retrieval of land evaporation

Science.gov (United States)

Pagán, B. R.; Martens, B.; Maes, W. H.; Miralles, D. G.

2017-12-01

Global satellite-based data sets of land evaporation overcome limitations in coverage of in situ measurements while retaining some observational nature. Although their potential for real world applications are promising, their value during dry conditions is still poorly understood. Most evaporation retrieval algorithms are not directly sensitive to soil moisture. An exception is the Global Land Evaporation Amsterdam Model (GLEAM), which uses satellite surface soil moisture and precipitation to account for land water availability. The existing methodology may greatly benefit from the optimal integration of novel observations of the land surface. Microwave vegetation optical depth (VOD) and near-infrared solar-induced fluorescence (SIF) are expected to reflect different aspects of evaporative stress. While the former is considered to be a proxy of vegetation water content, the latter is indicative of the activity of photosynthetic machinery. As stomata regulate both photosynthesis and transpiration, we expect a relationship between SIF and transpiration. An important motivation to incorporate observations in land evaporation calculations is that plant transpiration - usually the largest component of the flux - is extremely challenging to model due to species-dependent responses to drought. Here we present an innovative integration of VOD and SIF into the GLEAM evaporative stress function. VOD is utilized as a measurement of isohydricity to improve the representation of species specific drought responses. SIF is used for transpiration modelling, a novel application, and standardized by incoming solar radiation to better account for radiation-limited periods. Results are validated with global FLUXNET and International Soil Moisture Network data and demonstrate that the incorporation of VOD and SIF can yield accurate estimates of transpiration over large-scales, which are essential to further understand ecosystem-atmosphere feedbacks and the response of terrestrial

Defibrotide Injection

Science.gov (United States)

Defibrotide injection is used to treat adults and children with hepatic veno-occlusive disease (VOD; blocked blood ... the body and then returned to the body). Defibrotide injection is in a class of medications called ...

Oxyhalogenidy v pitné vodě

Czech Academy of Sciences Publication Activity Database

Janda, V.; Kastl, G.; Pivokonský, Martin

2015-01-01

Roč. 109, č. 5 (2015), s. 360-363 ISSN 0009-2770 R&D Projects: GA ČR GAP105/11/0247 Institutional support: RVO:67985874 Keywords : oxyhalides * drinking water * disinfectants Subject RIV: BK - Fluid Dynamics Impact factor: 0.279, year: 2015 http://www.chemicke-listy.cz/docs/full/2015_05_360-363.pdf

Consensus Report by the Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplant Consortium Joint Working Committees on Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents: Part 2-Focus on Ascites, Fluid and Electrolytes, Renal, and Transfusion Issues.

Science.gov (United States)

Mahadeo, Kris M; McArthur, Jennifer; Adams, Roberta H; Radhi, Mohamed; Angelo, Joseph; Jeyapalan, Asumthia; Nicol, Kathleen; Su, Leon; Rabi, Hanna; Auletta, Jeffery J; Pai, Vinita; Duncan, Christine N; Tamburro, Robert; Dvorak, Christopher C; Bajwa, Rajinder P S

2017-12-01

Even though hepatic veno-occlusive disease (VOD) is a potentially fatal complication of hematopoietic cell transplantation (HCT), there is paucity of research on the management of associated multiorgan dysfunction. To help provide standardized care for the management of these patients, the HCT Subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators and the Supportive Care Committee of the Pediatric Blood and Marrow Transplant Consortium, collaborated to develop evidence-based consensus guidelines. After conducting an extensive literature search, in part 2 of this series we discuss the management of fluids and electrolytes, renal dysfunction; ascites, pleural effusion, and transfusion and coagulopathy issues in patients with VOD. We consider the available evidence using the GRADE criteria. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

An Intercomparison of Vegetation Products from Satellite-based Observations used for Soil Moisture Retrievals

Science.gov (United States)

Vreugdenhil, Mariette; de Jeu, Richard; Wagner, Wolfgang; Dorigo, Wouter; Hahn, Sebastian; Bloeschl, Guenter

2013-04-01

Vegetation and its water content affect active and passive microwave soil moisture retrievals and need to be taken into account in such retrieval methodologies. This study compares the vegetation parameterisation that is used in the TU-Wien soil moisture retrieval algorithm to other vegetation products, such as the Vegetation Optical Depth (VOD), Net Primary Production (NPP) and Leaf Area Index (LAI). When only considering the retrieval algorithm for active microwaves, which was developed by the TU-Wien, the effect of vegetation on the backscattering coefficient is described by the so-called slope [1]. The slope is the first derivative of the backscattering coefficient in relation to the incidence angle. Soil surface backscatter normally decreases quite rapidly with the incidence angle over bare or sparsely vegetated soils, whereas the contribution of dense vegetation is fairly uniform over a large range of incidence angles. Consequently, the slope becomes less steep with increasing vegetation. Because the slope is a derivate of noisy backscatter measurements, it is characterised by an even higher level of noise. Therefore, it is averaged over several years assuming that the state of the vegetation doesn't change inter-annually. The slope is compared to three dynamic vegetation products over Australia, the VOD, NPP and LAI. The VOD was retrieved from AMSR-E passive microwave data using the VUA-NASA retrieval algorithm and provides information on vegetation with a global coverage of approximately every two days [2]. LAI is defined as half the developed area of photosynthetically active elements of the vegetation per unit horizontal ground area. In this study LAI is used from the Geoland2 products derived from SPOT Vegetation*. The NPP is the net rate at which plants build up carbon through photosynthesis and is a model-based estimate from the BiosEquil model [3, 4]. Results show that VOD and slope correspond reasonably well over vegetated areas, whereas in arid

A passion for hands-on troubleshooting

Energy Technology Data Exchange (ETDEWEB)

Tollinsky, N.

2010-09-01

This article discussed a state-of-the-art ventilation-on-demand (VOD) system that was installed at Vale's Creighton mine. RFID tracking technology was installed on some 60 pieces of mobile equipment. Instead of the conventional approach of installing tags on mobile equipment and exciters at check points, the tags were mounted in stationary locations while the exciters were hardened for mounting on mobile equipment. This arrangement was found to be more effective. It was also determined that variable frequency tags are not always necessary in VOD deployments; turning fans off and on based on the position of the vehicle was found to work well. The resolution to another VOD challenge associated with load-haul-dump machines was also discussed. These machines typically traverse several ventilation zones while going back and forth from the ore zones. It is impractical for the fans to be turned off or on as a loader proceeds through every zone, which is the normal practice. Instead, the system was programmed to distinguish between a loader and a bolter, ensuring that the fans remain on during the entire load-haul-dump operation. Tracking technology was also used to automatically turn on a water spray system for dust suppression during mucking operations. Wi-Fi and monitors in the cabs allow drivers to pinpoint the location of the trucks ahead of them, which is less cumbersome than radio communication. 1 fig.

The budget impact and cost-effectiveness of defibrotide for treatment of veno-occlusive disease with multi-organ dysfunction in patients post-hematopoietic stem cell transplant.

Science.gov (United States)

Veenstra, David L; Guzauskas, Gregory F; Villa, Kathleen F; Boudreau, Denise M

2017-05-01

A Phase-3 study of defibrotide compared with historical controls demonstrated a 23% improvement in 100-day survival post-hematopoietic stem cell transplantation (HSCT) among patients with veno-occlusive disease with multi-organ dysfunction (VOD with MOD). To estimate the budget impact and cost-effectiveness of introducing defibrotide to a transplant center. The authors developed a budget impact model from the perspective of a bone-marrow transplant center. It was estimated that 2.3% of adults and 4.2% of children would develop VOD with MOD following HSCT based on a retrospective hospital database analysis and the effect that treating patients with defibrotide would have on costs for adult and pediatric centers was estimated. A cost-utility analysis (CUA) was also developed to capture the long-term cost-effectiveness of defibrotide. Projected life expectancies in the two groups were estimated based on trial data, transplant registry data, studies of long-term survival among HSCT patients, and US population life-tables. There was an estimated 3% increase ($330,706) per year in total adult transplantation center costs associated with adopting defibrotide, and a incremental cost-effectiveness ratio (ICER) was $47,736 per QALY gained; 88% probability defibrotide was cost-effective at a $100,000/QALY threshold. The budget impact of defibrotide for a transplant center is relatively modest compared to the overall cost of transplantation. Defibrotide provides an important survival advantage for VOD with MOD patients, and the life years gained lead to defibrotide being highly cost-effective.

Assessing public benefits and costs of freight transportation projects : measuring shippers' value of delay on the freight system.

Science.gov (United States)

2012-07-01

Freight delay is detrimental to the national economy. In an effort to gauge the economic impact of freight delay due : to highway congestion, this project focuses on estimating shippers value of delay (VOD). We have accomplished : this through thr...

Relative skills of soil moisture and vegetation optical depth retrievals for agricultural drought monitoring

Science.gov (United States)

Soil moisture condition is an important indicator for agricultural drought monitoring. Through the Land Parameter Retrieval Model (LPRM), vegetation optical depth (VOD) as well as surface soil moisture (SM) can be retrieved simultaneously from brightness temperature observations from the Advanced Mi...

Pharmacokinetic profile of defibrotide in patients with renal impairment.

Science.gov (United States)

Tocchetti, Paola; Tudone, Elena; Marier, Jean-Francois; Marbury, Thomas C; Zomorodi, Katie; Eller, Mark

2016-01-01

Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is an unpredictable, potentially life-threatening complication of hematopoietic stem cell transplant conditioning. Severe VOD/SOS, generally associated with multiorgan dysfunction (pulmonary or renal dysfunction), may be associated with >80% mortality. Defibrotide, recently approved in the US, has demonstrated efficacy treating hepatic VOD/SOS with multiorgan dysfunction. Because renal impairment is prevalent in patients with VOD/SOS, this Phase I, open-label, two-part study in adults examined the effects of hemodialysis and severe or end-stage renal disease (ESRD) on defibrotide pharmacokinetics (PK). Part 1 compared defibrotide PK during single 6.25 mg/kg doses infused with and without dialysis. Part 2 assessed defibrotide plasma PK after multiple 6.25 mg/kg doses in nondialysis-dependent subjects with severe/ESRD versus healthy matching subjects. Among six subjects enrolled in Part 1, percent ratios of least-squares mean and 90% confidence intervals (CIs) on dialysis and nondialysis days were 109.71 (CI: 97.23, 123.78) for maximum observed plasma concentration (Cmax); 108.39 (CI: 97.85, 120.07) for area under the concentration-time curve to the time of the last quantifiable plasma concentration (AUC0-t); and 109.98 (CI: 99.39, 121.70) for AUC extrapolated to infinity (AUC0-∞). These ranges were within 80%-125%, indicating no significant effect of dialysis on defibrotide exposure/clearance. In Part 2, defibrotide exposure parameters in six subjects with severe/ESRD after multiple doses (AUC0-t, 113 µg·h/mL; AUC over dosing interval, 113 µg·h/mL; Cmax, 53.8 µg/mL) were within 5%-8% of parameters after the first dose (AUC0-t, 117 µg·h/mL; AUC0-∞, 118 µg·h/mL; Cmax, 54.9 µg/mL), indicating no accumulation. Defibrotide peak and extent of exposures in those with severe/ESRD were ~35%-37% and 50%-60% higher, respectively, versus controls, following single and multiple

Satellite passive microwaves for monitoring deforestation and drought-induced carbon losses in sub-Saharan Africa

Science.gov (United States)

Brandt, M.; Wigneron, J. P.; Chave, J.; Tagesson, T.; Penuelas, J.; Ciais, P.; Rasmussen, K.; Tian, F.; Mbow, C.; Al-Yaari, A.; Rodriguez-Fernandez, N.; Zhang, W.; Kerr, Y. H.; Tucker, C. J.; Mialon, A.; Verger, A.; Fensholt, R.

2017-12-01

The African continent is facing one of the driest periods in the past three decades and continuing deforestation. These disturbances threaten vegetation carbon (C) stocks and highlight the need for an operational tool for monitoring carbon stock dynamics. Knowledge of the amount, distribution, and turnover of carbon in African vegetation is crucial for understanding the effects of human pressure and climate change, but the shortcomings of optical and radar satellite products and the lack of systematic field inventories have led to considerable uncertainty in documenting patterns and dynamics of carbon stocks, in particular for drylands. Static carbon maps have been developed, but the temporal dynamics of carbon stocks cannot be derived from the benchmark maps, impeding timely, repeated, and reliable carbon assessments. The Soil Moisture and Ocean Salinity (SMOS) mission launched in 2009 was the first passive microwave-based satellite system operating at L-band (1.4 GHz) frequency. The low frequencies allow the satellite to sense deep within the canopy layer with less influence by the green non-woody plant components. The vegetation optical depth (VOD) derived from SMOS, henceforth L-VOD, is thus less sensitive to saturation effects, marking an important step forward in the monitoring of carbon as a natural resource. In this study, we apply for the first time L-VOD to quantify the inter-annual dynamics of aboveground carbon stocks for the period 2010-2016. We use this new technique to document patterns of carbon gains and losses in sub-Saharan Africa with a focus of dryland response to recent dry years. Results show that drylands lost carbon at a rate of -0.06 Pg C y-1 associated with drying trends, while humid areas lost only -0.02 Pg C y-1. These trends reflect a high inter-annual variability with a very wet (2011) and a very dry year (2016) associated with carbon gains and losses respectively. This study demonstrates, first, the operational applicability of L-VOD

Defibrotide in the treatment of hepatic veno-occlusive disease

Directory of Open Access Journals (Sweden)

Fulgenzi A

2016-10-01

Full Text Available Alessandro Fulgenzi, Maria Elena Ferrero Department of Biomedical Sciences for Health, University of Milan, Milan, Italy Abstract: Hepatic veno-occlusive disease (VOD, also known as sinusoidal obstruction syndrome (SOS, represents the most frequent complication in patients in early phase following hematopoietic stem-cell transplantation (HSCT. In its severe form, VOD/SOS can be associated with multiorgan failure and with a mortality rate >80% by day +100. Defibrotide (DF (a mixture of 90% single-stranded phosphodiester oligonucleotides and 10% double-stranded phosphodiester oligonucleotides derived from controlled depolarization of porcine intestinal mucosal DNA has been proposed for the treatment of SOS due to its ability to restore thrombo-fibrinolytic balance and protect endothelial cells. The present review highlights why the mechanisms of action of DF allow its successful use in the prevention and treatment of SOS following HSCT. Keywords: hepatic veno-occlusive disease, hematopoietic stem-cell transplantation, defibrotide

THE NEXT GENERATION VIRGO CLUSTER SURVEY. XIX. TOMOGRAPHY OF MILKY WAY SUBSTRUCTURES IN THE NGVS FOOTPRINT

Energy Technology Data Exchange (ETDEWEB)

Lokhorst, Deborah; Starkenburg, Else; Navarro, Julio F. [Department of Physics and Astronomy, University of Victoria, Victoria, BC V8P 1A1, Canada (Canada); McConnachie, Alan W.; Ferrarese, Laura; Côté, Patrick; Gwyn, Stephen D. J. [National Research Council, Herzberg Astronomy and Astrophysics, 5071 West Saanich Road, Victoria, BC V9E 2E7 (Canada); Liu, Chengze [Center for Astronomy and Astrophysics, Department of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240 (China); Peng, Eric W. [Department of Astronomy, Peking University, Beijing 100871 (China); Cuillandre, Jean-Charles [CEA/IRFU/SAP, Laboratoire AIM Paris-Saclay, CNRS/INSU, Université Paris Diderot, Observatoire de Paris, PSL Research University, F-91191 Gif-sur-Yvette Cedex (France); Guhathakurta, Puragra, E-mail: dml@uvic.ca [Department of Astronomy and Astrophysics, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 (United States)

2016-03-10

The Next Generation Virgo Cluster Survey (NGVS) is a deep u*giz survey targeting the Virgo Cluster of galaxies at 16.5 Mpc. This survey provides high-quality photometry over an ∼100 deg{sup 2} region straddling the constellations of Virgo and Coma Berenices. This sightline through the Milky Way is noteworthy in that it intersects two of the most prominent substructures in the Galactic halo: the Virgo overdensity (VOD) and Sagittarius stellar stream (close to its bifurcation point). In this paper, we use deep u*gi imaging from the NGVS to perform tomography of the VOD and Sagittarius stream using main-sequence turnoff (MSTO) stars as a halo tracer population. The VOD, whose centroid is known to lie at somewhat lower declinations (α ∼ 190°, δ ∼ −5°) than is covered by the NGVS, is nevertheless clearly detected in the NGVS footprint at distances between ∼8 and 25 kpc. By contrast, the Sagittarius stream is found to slice directly across the NGVS field at distances between 25 and 40 kpc, with a density maximum at ≃35 kpc. No evidence is found for new substructures beyond the Sagittarius stream, at least out to a distance of ∼90 kpc—the largest distance to which we can reliably trace the halo using MSTO stars. We find clear evidence for a distance gradient in the Sagittarius stream across the ∼30° of sky covered by the NGVS and its flanking fields. We compare our distance measurements along the stream with those predicted by leading stream models.

Assessment of Wildfire Risk in Southern California with Live Fuel Moisture Measurement and Remotely Sensed Vegetation Water Content Proxies

Science.gov (United States)

Jia, S.; Kim, S. H.; Nghiem, S. V.; Kafatos, M.

2017-12-01

Live fuel moisture (LFM) is the water content of live herbaceous plants expressed as a percentage of the oven-dry weight of plant. It is a critical parameter in fire ignition in Mediterranean climate and routinely measured in sites selected by fire agencies across the U.S. Vegetation growing cycle, meteorological metrics, soil type, and topography all contribute to the seasonal and inter-annual variation of LFM, and therefore, the risk of wildfire. The optical remote sensing-based vegetation indices (VIs) have been used to estimate the LFM. Comparing to the VIs, microwave remote sensing products have advantages like less saturation effect in greenness and representing the water content of the vegetation cover. In this study, we established three models to evaluate the predictability of LFM in Southern California using MODIS NDVI, vegetation temperature condition index (VTCI) from downscaled Soil Moisture Active Passive (SMAP) products, and vegetation optical depth (VOD) derived by Land Parameter Retrieval Model. Other ancillary variables, such as topographic factors (aspects and slope) and meteorological metrics (air temperature, precipitation, and relative humidity), are also considered in the models. The model results revealed an improvement of LFM estimation from SMAP products and VOD, despite the uncertainties introduced in the downscaling and parameter retrieval. The estimation of LFM using remote sensing data can provide an assessment of wildfire danger better than current methods using NDVI-based growing seasonal index. Future study will test the VOD estimation from SMAP data using the multi-temporal dual channel algorithm (MT-DCA) and extend the LFM modeling to a regional scale.

THE NEXT GENERATION VIRGO CLUSTER SURVEY. XIX. TOMOGRAPHY OF MILKY WAY SUBSTRUCTURES IN THE NGVS FOOTPRINT

International Nuclear Information System (INIS)

Lokhorst, Deborah; Starkenburg, Else; Navarro, Julio F.; McConnachie, Alan W.; Ferrarese, Laura; Côté, Patrick; Gwyn, Stephen D. J.; Liu, Chengze; Peng, Eric W.; Cuillandre, Jean-Charles; Guhathakurta, Puragra

2016-01-01

The Next Generation Virgo Cluster Survey (NGVS) is a deep u*giz survey targeting the Virgo Cluster of galaxies at 16.5 Mpc. This survey provides high-quality photometry over an ∼100 deg 2 region straddling the constellations of Virgo and Coma Berenices. This sightline through the Milky Way is noteworthy in that it intersects two of the most prominent substructures in the Galactic halo: the Virgo overdensity (VOD) and Sagittarius stellar stream (close to its bifurcation point). In this paper, we use deep u*gi imaging from the NGVS to perform tomography of the VOD and Sagittarius stream using main-sequence turnoff (MSTO) stars as a halo tracer population. The VOD, whose centroid is known to lie at somewhat lower declinations (α ∼ 190°, δ ∼ −5°) than is covered by the NGVS, is nevertheless clearly detected in the NGVS footprint at distances between ∼8 and 25 kpc. By contrast, the Sagittarius stream is found to slice directly across the NGVS field at distances between 25 and 40 kpc, with a density maximum at ≃35 kpc. No evidence is found for new substructures beyond the Sagittarius stream, at least out to a distance of ∼90 kpc—the largest distance to which we can reliably trace the halo using MSTO stars. We find clear evidence for a distance gradient in the Sagittarius stream across the ∼30° of sky covered by the NGVS and its flanking fields. We compare our distance measurements along the stream with those predicted by leading stream models

Úvod do neparametrických metod

OpenAIRE

Prelecová, Natália

2012-01-01

Title: Introduction to Nonparametric Methods Author: Natália Prelecová Department: Department of Probability and Mathematical Statistics Supervisor: doc. Mgr. Michal Kulich,Ph.D., Department of Probability and Mathematical Statistics Abstract: The aim of this thesis is to introduce basic nonparametric methods. Nonparametric methods embrace a large class of statistical procedures which do not assume specific data distribution such as normal distribution. They often re- present the only availab...

Special issue: Proceedings of the XII. Czech Ichthyological Conference

Czech Academy of Sciences Publication Activity Database

Kubečka, Jan

2011-01-01

Roč. 60, č. 2 (2011), s. 91-92 ISSN 0139-7893. [Czech Ichthyological Conference /XII./. Vodňany, 19.05.2010-20.05.2010] Institutional research plan: CEZ:AV0Z60170517 Keywords : zoology * ichthyology Subject RIV: EG - Zoology Impact factor: 0.554, year: 2011

An Outbreak of Hepatic Veno-Occlusive Disease in Western Afghanistan Associated with Exposure to Wheat Flour Contaminated with Pyrrolizidine Alkaloids

Directory of Open Access Journals (Sweden)

Faizullah Kakar

2010-01-01

Full Text Available Pyrrolizidine alakloids (PAs are known to cause hepatic veno-occlusive disease (VOD. Outbreaks have occurred in Western Afghanistan since 1974, the latest in February 2008. We conducted an outbreak investigation using a case-control design. Sixty-seven cases of VOD were compared with 199 community controls. Consumption of bread was strongly associated with disease (adjusted odds ratio: 35.8 [95%CI: 7.6–168.2]. Toxic doses of PA were found in plant extracts and in samples of wheat flour taken from the study area. Compared to wheat flour there was 1000 times less PA in milk and whey and in water samples the PA content was zero. Although direct analysis was not possible, contaminated wheat flour used to make bread was the likely source of PA causing the outbreak. Eating a more varied diet including meat and fruit may be protective. Prevention and control measures will rely on community awareness and agricultural interventions to ensure safety of the food supply.

An Outbreak of Hepatic Veno-Occlusive Disease in Western Afghanistan Associated with Exposure to Wheat Flour Contaminated with Pyrrolizidine Alkaloids

Science.gov (United States)

Kakar, Faizullah; Akbarian, Zarif; Leslie, Toby; Mustafa, Mir Lais; Watson, John; van Egmond, Hans P.; Omar, Mohammad Fahim; Mofleh, Jawad

2010-01-01

Pyrrolizidine alakloids (PAs) are known to cause hepatic veno-occlusive disease (VOD). Outbreaks have occurred in Western Afghanistan since 1974, the latest in February 2008. We conducted an outbreak investigation using a case-control design. Sixty-seven cases of VOD were compared with 199 community controls. Consumption of bread was strongly associated with disease (adjusted odds ratio: 35.8 [95%CI: 7.6–168.2]). Toxic doses of PA were found in plant extracts and in samples of wheat flour taken from the study area. Compared to wheat flour there was 1000 times less PA in milk and whey and in water samples the PA content was zero. Although direct analysis was not possible, contaminated wheat flour used to make bread was the likely source of PA causing the outbreak. Eating a more varied diet including meat and fruit may be protective. Prevention and control measures will rely on community awareness and agricultural interventions to ensure safety of the food supply. PMID:20652038

An Outbreak of Hepatic Veno-Occlusive Disease in Western Afghanistan Associated with Exposure to Wheat Flour Contaminated with Pyrrolizidine Alkaloids

International Nuclear Information System (INIS)

Kakar, F.; Akbarian, Z.; Mustafa, M.L.; Omar, M.F.; Mofleh, J.; Toby Leslie, T.; Watson, J.; Egmond, H.P.V.

2010-01-01

Pyrrolizidine alkaloids (PAs) are known to cause hepatic veno-occlusive disease (VOD). Outbreaks have occurred in Western Afghanistan since 1974, the latest in February 2008. We conducted an outbreak investigation using a case-control design. Sixty-seven cases of VOD were compared with 199 community controls. Consumption of bread was strongly associated with disease (adjusted odds ratio: 35.8 [95%CI: 7.6 168.2]). Toxic doses of PA were found in plant extracts and in samples of wheat flour taken from the study area. Compared to wheat flour there was 1000 times less PA in milk and whey and in water samples the PA content was zero. Although direct analysis was not possible, contaminated wheat flour used to make bread was the likely source of PA causing the outbreak. Eating a more varied diet including meat and fruit may be protective. Prevention and control measures will rely on community awareness and agricultural interventions to ensure safety of the food supply.

Estimating ecosystem iso/anisohydry using microwave satellite data and its applications in ecohydrology

Science.gov (United States)

Li, Y.; Guan, K.; Gentine, P.; Konings, A. G.; Bhattacharya, A.; Meinzer, F. C.; Kimball, J. S.; Xu, X.; Anderegg, W.; McDowell, N. G.; Martínez-Vilalta, J.; Long, D. G.; Good, S. P.

2017-12-01

The concept of iso/anisohydry describes the degree to which plants regulate their water status, operating from isohydric with strict stomatal closure to anisohydric with greater stomatal conductance under drying conditions. Though some species-level measures of iso/anisohydry exist at limited locations, ecosystem scale information is still largely unavailable. In this study, we use diurnal observations from active (Ku-Band backscatter from QuikSCAT) and passive (X-band Vegetation Optical Depth [VOD] from AMSR-E) microwave satellite data to estimate global ecosystem iso/anisohydry. The two independent estimates from radar backscatter and VOD show good agreement at low and mid-latitudes but diverge at high latitudes. Grasslands, croplands, wetlands, and open shrublands are more anisohydric, whereas evergreen broadleaf and deciduous broadleaf forests are more isohydric. The direct validation with upscaled in-situ species iso/anisohydry estimates indicates that the VOD estimates have much better agreement than the backscatter in terms of their iso/anisohydry metrics. The indirect validation suggests that both estimates are consistent with prior knowledge that vegetation water status of anisohydric ecosystems more closely tracks environmental fluctuations of water availability and demand than their isohydric counterparts. The ecosystem level iso/anisohydry can be applied to reveal new insights into spatio-temporal ecosystem response to droughts. We conducted a case study to demonstrate the potential application of iso/anisohydry. We find that during the 2011 drought in US, over the drought affected region in the southern US, isohydric ecosystems experienced larger decline in productivity (NDVI and GPP) than anisohydric ones. However, during the 2012 drought in central US, both isohydric and anisohydric ecosystems exhibited similar decline in productivity.

Estimating Global Ecosystem Isohydry/Anisohydry Using Active and Passive Microwave Satellite Data

Science.gov (United States)

Li, Yan; Guan, Kaiyu; Gentine, Pierre; Konings, Alexandra G.; Meinzer, Frederick C.; Kimball, John S.; Xu, Xiangtao; Anderegg, William R. L.; McDowell, Nate G.; Martinez-Vilalta, Jordi; Long, David G.; Good, Stephen P.

2017-12-01

The concept of isohydry/anisohydry describes the degree to which plants regulate their water status, operating from isohydric with strict regulation to anisohydric with less regulation. Though some species level measures of isohydry/anisohydry exist at a few locations, ecosystem-scale information is still largely unavailable. In this study, we use diurnal observations from active (Ku-Band backscatter from QuikSCAT) and passive (X-band vegetation optical depth (VOD) from Advanced Microwave Scanning Radiometer on EOS Aqua) microwave satellite data to estimate global ecosystem isohydry/anisohydry. Here diurnal observations from both satellites approximate predawn and midday plant canopy water contents, which are used to estimate isohydry/anisohydry. The two independent estimates from radar backscatter and VOD show reasonable agreement at low and middle latitudes but diverge at high latitudes. Grasslands, croplands, wetlands, and open shrublands are more anisohydric, whereas evergreen broadleaf and deciduous broadleaf forests are more isohydric. The direct validation with upscaled in situ species isohydry/anisohydry estimates indicates that the VOD-based estimates have much better agreement than the backscatter-based estimates. The indirect validation with prior knowledge suggests that both estimates are generally consistent in that vegetation water status of anisohydric ecosystems more closely tracks environmental fluctuations of water availability and demand than their isohydric counterparts. However, uncertainties still exist in the isohydry/anisohydry estimate, primarily arising from the remote sensing data and, to a lesser extent, from the methodology. The comprehensive assessment in this study can help us better understand the robustness, limitation, and uncertainties of the satellite-derived isohydry/anisohydry estimates. The ecosystem isohydry/anisohydry has the potential to reveal new insights into spatiotemporal ecosystem response to droughts.

Self-organizing algorithms for cache cooperation in content distribution networks

NARCIS (Netherlands)

Borst, S.C.; Gupta, V.; Walid, A.

2009-01-01

Introduction: The on-demand delivery of video content is anticipated to show tremendous growth over the next few years, driven by the huge popularity of user-generated video clips and the expansion of VoD libraries. Even stronger growth is likely to be fueled by the proliferation of IPTV services

Personalised TV ads are the future – but is it time to panic?

OpenAIRE

Blake, James.

2015-01-01

TV Advertising is evolving quickly. This article examines how the popularity of viewing content on mobile platforms is changing the way we advertise. VOD and OTT media services have meant that advertisers can now automate and personalise their TV advertising. It's having a significant impact on the UK TV business model.

Maailma põnevamatest ja populaarsematest maratonidest / Ahti Reinup

Index Scriptorium Estoniae

Reinup, Ahti

2015-01-01

Kõige huvitavamatest, karmimatest, pikematest või rahvarohkematest süstamaratonidest maailmas: The Dusi Canoe Marathon Lõuna-Aafrika Vabariigis, Yukon River Quest Canadas, Dalslad Kanot Maraton Rootsis, Adige Marathon Itaalias, Krumlovský vodácký maraton Tšehhis, Marathon International des Gorges de l'Ardèche Prantsusmaal ja veel mõningatest teistest

WERYFIKACJA MOŻLIWOŚCI ZASTOSOWANIA WSKAŹNIKA ITS DO OCENY STANU TROFICZNEGO ZBIORNIKA DOBCZYCKIEGO

Directory of Open Access Journals (Sweden)

Elena NEVEROVA-DZIOPAK

2016-05-01

Full Text Available W ostatnich latach problem eutrofizacji stał się powszechny nie tylko w wodach stojących ale także w płynących. Budzi on spore zainteresowanie zwłaszcza gdy zaczyna dotyczyć wód przeznaczonych do zaopatrzenia ludzi w wodę do spożycia. Zbiornik Dobczycki o którym traktuje artykuł jest właśnie takim rezerwuarem. Tu ujmowana jest woda dla mieszkańców Krakowa. W literaturze spotyka się stwierdzenia, że wody zbiornika zawsze były podatne na eutrofizację ze względu na ładunki biogenów które są wnoszone do niego przez Rabę. Problem oceny stopnia eutrofizacji Zbiornika Dobczyckiego został więc podjęty nie tyle ze względów poznawczych, co utylitarnych. Wymagał rzetelnej i szczegółowej analizy danych pomiarowych pochodzących z monitoringu. Do oceny zjawiska eutrofizacji wykorzystano integralny wskaźnik troficzności ITS. Jest on jednym z coraz powszechniej stosowanych obecnie zagregowanych wskaźników. Dostrzeżono że graniczne wartości pojedynczych parametrów niekoniecznie odzwierciedlają stan trofii i uprawniają do wnioskowania o zjawisku eutrofizacji. Zastosowanie wskaźnika ITS wiąże się z wykorzystaniem parametrów takich jak pH i nasycenie wody tlenem, które odzwierciedlają bilans gazowy w wodach, zmieniający się wraz ze zmianą bilansu procesów produkcji i rozkładu materii organicznej. Nie wymaga on więc szczegółowych oznaczeń monitoringowych, przez co może być wykorzystywany jako uniwersalny sposób oceny trofii. W artykule uzasadniono wybór wskaźnika ITS jako metody oceny trofii na podstawie analizy statystycznej danych monitoringu Zbiornika pochodzących z okresu wieloletniego. Uwiarygodniło to ocenę i pozwoliło dostrzec pewne prawidłowości procesu oraz jego dynamikę. Na jej podstawie możliwa jest prognoza prawdopodobnego scenariusza dalszego rozwoju zjawiska. Utrzymujący się w minionych 15 latach stan pograniczny zaawansowanej mezotrofii/eutrofii przy jednoczesnej dobrej

Inotuzumab ozogamicin in adults with relapsed or refractory CD22-positive acute lymphoblastic leukemia: a phase 1/2 study.

Science.gov (United States)

DeAngelo, Daniel J; Stock, Wendy; Stein, Anthony S; Shustov, Andrei; Liedtke, Michaela; Schiffer, Charles A; Vandendries, Erik; Liau, Katherine; Ananthakrishnan, Revathi; Boni, Joseph; Laird, A Douglas; Fostvedt, Luke; Kantarjian, Hagop M; Advani, Anjali S

2017-06-27

This study evaluated the safety, antitumor activity, pharmacokinetics, and pharmacodynamics of inotuzumab ozogamicin (InO) for CD22-positive relapsed/refractory acute lymphoblastic leukemia. In phase 1, patients received InO 1.2 (n = 3), 1.6 (n = 12), or 1.8 (n = 9) mg/m 2 per cycle on days 1, 8, and 15 over a 28-day cycle (≤6 cycles). The recommended phase 2 dose (RP2D) was confirmed (expansion cohort; n = 13); safety and activity of InO were assessed in patients receiving the RP2D in phase 2 (n = 35) and in all treated patients (n = 72). The RP2D was 1.8 mg/m 2 per cycle (0.8 mg/m 2 on day 1; 0.5 mg/m 2 on days 8 and 15), with reduction to 1.6 mg/m 2 per cycle after complete remission (CR) or CR with incomplete marrow recovery (CRi). Treatment-related toxicities were primarily cytopenias. Four patients experienced treatment-related venoocclusive disease/sinusoidal obstruction syndrome (VOD/SOS; 1 fatal). Two VOD/SOS events occurred during treatment without intervening transplant; of 24 patients proceeding to poststudy transplant, 2 experienced VOD/SOS after transplant. Forty-nine (68%) patients had CR/CRi, with 41 (84%) achieving minimal residual disease (MRD) negativity. Median progression-free survival was 3.9 (95% confidence interval, 2.9-5.4) months; median overall survival was 7.4 (5.7-9.2) months for all treated patients, with median 23.7 (range, 6.8-29.8) months of follow-up for all treated patients alive at data cutoff. Achievement of MRD negativity was associated with higher InO exposure. InO was well tolerated and demonstrated high single-agent activity and MRD-negativity rates. This trial was registered at www.clinicaltrials.gov as #NCT01363297.

Variations in global land surface phenology: a comparison of satellite optical and passive microwave data

Science.gov (United States)

Tong, X.; Tian, F.; Brandt, M.; Zhang, W.; Liu, Y.; Fensholt, R.

2017-12-01

Changes in vegetation phenological events are among the most sensitive biological responses to climate change. In last decades, facilitating by satellite remote sensing techniques, land surface phenology (LSP) have been monitored at global scale using proxy approaches as tracking the temporal change of a satellite-derived vegetation index. However, the existing global assessments of changes in LSP are all established on the basis of leaf phenology using NDVI derived from optical sensors, being responsive to vegetation canopy cover and greenness. Instead, the vegetation optical depth (VOD) parameter from passive microwave sensors, which is sensitive to the aboveground vegetation water content by including as well the woody components in the observations, provides an alternative, independent and comprehensive means for global vegetation phenology monitoring. We used the unique long-term global VOD record available for the period 1992-2012 to monitoring the dynamics of LSP metrics (length of season, start of season and end of season) in comparison with the dynamics of LSP metrics derived from the latest GIMMS NDVI3G V1. We evaluated the differences in the linear trends of LSP metrics between two datasets. Currently, our results suggest that the level of seasonality variation of vegetation water content is less than the vegetation greenness. We found significant phenological changes in vegetation water content in African woodlands, where has been reported with little leaf phenological change regardless of the delays in rainfall onset. Therefore, VOD might allow us to detect temporal shifts in the timing difference of vegetation water storage vs. leaf emergence and to see if some ecophysiological thresholds seem to be reached, that could cause species turnover as climate change-driven alterations to the African monsoon proceed.

Heavy metals and metallothionein in vespertilionid bats foraging over aquatic habitats in the Czech Republic

Czech Academy of Sciences Publication Activity Database

Pikula, J.; Zukal, Jan; Adam, V.; Banďouchová, H.; Beklová, M.; Hájková, P.; Horáková, J.; Kizek, R.; Valentíková, L.

2010-01-01

Roč. 29, č. 3 (2010), s. 501-506 ISSN 0730-7268. [International Workshop on Aquatic Toxicology and Biomonitoring /1./. Vodňany, 27.08.2008-29.08.2008] Institutional research plan: CEZ:AV0Z60930519 Keywords : Microchiroptera * insect foraging * metallic elements * bioaccumulation Subject RIV: EG - Zoology Impact factor: 3.026, year: 2010

Traffic Management of Video on Demand: An Analysis of Investments for Improving the End User’s Quality of Experience

Directory of Open Access Journals (Sweden)

Francesca Di Pillo

2016-05-01

Full Text Available The current escalation in user demand for web contents, particularly Video on Demand (VoD, is causing a continu‐ ing increase in both the types of web traffic and the volumes of data transmitted. The greater demand arises from the new means of communication employed by individuals and companies, as well as the development of readily usable applications distributed by ‘app stores’. In this paper, we suggest that the stakeholders of a VoD frame‐ work, the Content Providers (CPs and the Internet Service Providers (telcos/ISPs, should guarantee a solid Quality of Experience (QoE to the end user through two potential investments: either in ultra-broadband (UBB or in the technologies for the acceleration of web content, known as the Content Delivery Network (CDN and Transparent Internet Caching (TIC. The aim of the paper is to analyse these investments in terms of providers' profits. The base hypothesis is that the investments are subsidized by the CPs, which, in recent years, have indeed been directing a large part of their revenues towards investments in network infrastructure.

Penile vascular diagnostic categorization using penile duplex Doppler ultrasound: Differences in vascular hemodynamics parameters by differences in anatomic sampling location

Directory of Open Access Journals (Sweden)

Fabio Pezzoni

2016-10-01

Full Text Available Objectives. In 2013 the International Society for Sexual Medicine(ISSM published the guidelines regarding the standard operating procedure (SOP for penile duplex Doppler ultrasound (PDDU. Although ISSM-SOP have given important strides in reducing interobserver variability in PDDU by procedural protocol and parameters these guidelines do not address the anatomic location along the penis at which hemodynamic measurements have to be done. In our opinion a “double sampling” may be interesting to detect the arteriogenic or venogenic nature of the erectile dysfunction (ED. In particular sampling measurements at the “crus” (at the level of the peno-scrotal junction may be significative for detection of veno-occlusive dysfunction (VOD,whereas an evaluation at “mid penis” (1/2 distance between peno-scrotal junction and coronal sulcus, may be useful to diagnose an arterial insufficiency (AI. Material and Methods. We evalued 90 men, mean age 56.3, affected with ED of medium degree, responder to PDE5-I that urdergone to PDDU and also responder after pharmacologic intracavernosal injection (PIIof prostaglandin E1 20 mcg, with rigid erection and normal maintenance. We moreover evalued 90 men in youthful age (mean 35.2, in absence of vascular risk factors, no responder to PDE5-I that undergone to PDDU by PII at high dosage (bimix: prostaglandin E1 20 mcg, papaverine 20 mg. Results. In the first pool the sampling at “mid penis” resulted significative for arterial insuffciency (AI in 81% (73, in presence of normal or borderline end diastolic velocity (EDV. Sampling at the “crus” resulted negative for VOD in 90% (81. In the second pool, 66.6% (60 resulted responder with rigid erection and normal maintenance in presence of normal hemodynamic parameters: peak systolic velocity (PSV and end diastolic velocity (EDV both at the “crus” and at “mid penis” sampling. 33.4% (30 responded with a semirigid erection and manifested a constant

Růstové vlastnosti a problematika chovu jesetera sibiřského (Acipenser baerii) v podmínkách České republiky

Czech Academy of Sciences Publication Activity Database

Prokeš, Miroslav; Baruš, Vlastimil; Peňáz, Milan; Baránek, V.

2003-01-01

Roč. 39, 1-2 (2003), s. 99-103 ISSN 0007-389X. [Nové technologie a nové druhy v akvakultuře. Vodňany, 24.04.2003-25.04.2003] R&D Projects: GA AV ČR IAA6093104; GA AV ČR KSK6005114 Institutional research plan: CEZ:AV0Z6093917 Keywords : Acipenser baerii * growth rate Subject RIV: GL - Fishing

Defibrotide, a polydisperse mixture of single-stranded phosphodiester oligonucleotides with lifesaving activity in severe hepatic veno-occlusive disease: clinical outcomes and potential mechanisms of action.

Science.gov (United States)

Kornblum, Noah; Ayyanar, Kanyalakshmi; Benimetskaya, Luba; Richardson, Paul; Iacobelli, Massimo; Stein, C A

2006-01-01

Veno-occlusive disease of the liver (VOD) remains a troubling and potentially fatal complication of high-dose chemotherapy and hematopoietic stem cell transplantation conditioning regimens. No effective therapy has been available for these patients to date, and the best supportive care measures remain woefully inadequate. Defibrotide (DF) (Gentium, S.p.A., Como, Italy), a polydisperse mixture of all the single-stranded phosphodiester oligodeoxyribonucleotides that can be obtained from the controlled depolymerization of porcine intestinal mucosal genomic DNA, seems to offer a safe and effective treatment for some patients suffering from severe VOD, a condition for which no accepted standard therapy currently exists. Early clinical studies evaluating the efficacy of DF for the treatment of severe VOD in patients undergoing hematopoietic stem cell transplantation have been very encouraging. Approximately 45% of the patients treated in multiple initial phase II clinical trials achieved a complete response at day +100, demonstrating normalization of serum bilirubin and resolution of the clinical syndrome. However, although multi-institutional, these represented single arm studies. A large, FDA-approved, pivotal, prospective, multi-institutional, global phase III trial of DF vs. historical controls (best available therapy) commenced in the first quarter of 2006 and should provide further validation of DF's efficacy. The drug seems to have few significant side effects, and almost all test subjects who have received this treatment have tolerated it well. Although the mechanism of action remains unclear, the drug exerts minimal systemic anticoagulant effects yet appears to induce numerous antithrombotic and profibrinolytic effects both in vitro and in vivo. It may function as an adenosine receptor agonist and causes increased concentrations of endogenous prostaglandins, which modulate thrombomodulin, platelets, and fibrinolysis. It also appears to block lipopolysaccharide

Pharmacokinetic profile of defibrotide in patients with renal impairment

Directory of Open Access Journals (Sweden)

Tocchetti P

2016-08-01

Full Text Available Paola Tocchetti,1 Elena Tudone,2 Jean-Francois Marier,3 Thomas C Marbury,4 Katie Zomorodi,5 Mark Eller6 1Gentium, 2Clinical Operations, Gentium, Villa Guardia, Como, Italy; 3Reporting and Analysis Services, Pharsight, a Certara Company, Montreal, Quebec, Canada; 4Orlando Clinical Research Center, Orlando, FL, 5Early Development and Clinical Pharmacology, Jazz Pharmaceuticals, 6Early Drug Development, Jazz Pharmaceuticals, Palo Alto, CA, USA Abstract: Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS, is an unpredictable, potentially life-threatening complication of hematopoietic stem cell transplant conditioning. Severe VOD/SOS, generally associated with multiorgan dysfunction (pulmonary or renal dysfunction, may be associated with >80% mortality. Defibrotide, recently approved in the US, has demonstrated efficacy treating hepatic VOD/SOS with multiorgan dysfunction. Because renal impairment is prevalent in patients with VOD/SOS, this Phase I, open-label, two-part study in adults examined the effects of hemodialysis and severe or end-stage renal disease (ESRD on defibrotide pharmacokinetics (PK. Part 1 compared defibrotide PK during single 6.25 mg/kg doses infused with and without dialysis. Part 2 assessed defibrotide plasma PK after multiple 6.25 mg/kg doses in nondialysis-dependent subjects with severe/ESRD versus healthy matching subjects. Among six subjects enrolled in Part 1, percent ratios of least-squares mean and 90% confidence intervals (CIs on dialysis and nondialysis days were 109.71 (CI: 97.23, 123.78 for maximum observed plasma concentration (Cmax; 108.39 (CI: 97.85, 120.07 for area under the concentration–time curve to the time of the last quantifiable plasma concentration (AUC0–t; and 109.98 (CI: 99.39, 121.70 for AUC extrapolated to infinity (AUC0–∞. These ranges were within 80%–125%, indicating no significant effect of dialysis on defibrotide exposure/clearance. In Part 2, defibrotide

Život s vodícím psem

OpenAIRE

Bártová, Lucie

2008-01-01

Thesis discusses about blind people, guide-dogs and their benefits. Thesis describes the troubles of blind in daily life, insufficient guide-dog's legislation and also negative experiences of blind with hospital staff. Comparison of life with or without the guide-dog is stressed on. Thesis is based on quantitative analysis of guide-dog's benefits to blind, experiences and troubles of blind with guide-dog and also experiences and opinions of blind without guide- dog. 40 blind people with diffe...

Proč sodík vybuchuje ve vodě?

Czech Academy of Sciences Publication Activity Database

Jungwirth, Pavel

2016-01-01

Roč. 110, č. 5 (2016), s. 330-334 ISSN 0009-2770 R&D Projects: GA ČR(CZ) GBP208/12/G016 Institutional support: RVO:61388963 Keywords : alkali metals * water * Coulomb explosion * ultrafast camera * molecular dynamics Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 0.387, year: 2016 http://www.chemicke-listy.cz/docs/full/2016_05_330-334.pdf

Oil Spill Response Technology Initiation Decision Report to the Pollution Abatement Ashore Program

Science.gov (United States)

2007-12-01

music and entertainment content at broadband-like speeds. On Sprint’s Power Vision(SM) network, MOTOKRZR, MOTORAZR and MOTOSLVR will be the only...that streams full-length movies, including recent box-office hits and timeless favorites from Buena Vista VOD, Lionsgate, Sony Pictures Home... Entertainment and Universal Pictures. Sprint Movies offers a growing list of more than 45 titles, including "National Treasure," "Spider-Man 2" and

Fiber to the home: next generation network

Science.gov (United States)

Yang, Chengxin; Guo, Baoping

2006-07-01

Next generation networks capable of carrying converged telephone, television (TV), very high-speed internet, and very high-speed bi-directional data services (like video-on-demand (VOD), Game etc.) strategy for Fiber To The Home (FTTH) is presented. The potential market is analyzed. The barriers and some proper strategy are also discussed. Several technical problems like various powering methods, optical fiber cables, and different network architecture are discussed too.

Effect of nitrite on early-life stages of common carp (Cyprinus carpio L.)

Czech Academy of Sciences Publication Activity Database

Kroupová, H.; Prokeš, Miroslav; Mácová, S.; Peňáz, Milan; Baruš, Vlastimil; Novotný, L.; Máchová, J.

2010-01-01

Roč. 29, č. 3 (2010), s. 535-540 ISSN 0730-7268. [International Workshop on Aquatic Toxicology and Biomonitoring /1./. Vodňany, 27.08.2008-29.08.2008] Institutional research plan: CEZ:AV0Z60930519 Keywords : Embryo–larval toxicity test * Lowest-observed-effect concentration * No-observed-effect concentration * Early development * Histopathology Subject RIV: DN - Health Impact of the Environment Quality Impact factor: 3.026, year: 2010

Update on the use of defibrotide.

Science.gov (United States)

Guglielmelli, Tommasina; Bringhen, Sara; Palumbo, Antonio

2012-03-01

Defibrotide is a polydisperse oligonucleotide obtained from porcine intestinal mucosa and prepared by controlled depolymerization of DNA. It is a nucleic acid polymer, predominantly single-stranded, which has anti-ischemic and anti-thrombotic properties. The efficacy and safety of defibrotide in the treatment of veno-occlusive disease (VOD) occurring after high-dose chemotherapy and hematopoietic stem-cell transplantation is now well established in Phase II - III trials. A recent randomized, Phase III trial in pediatric patients has also demonstrated its role in the prevention of VOD. Preclinical studies reported the inhibitory effects of defibrotide on myeloma cells' growth through an antiangiogenic action and a regulation of the tumor-microenvironment interactions. A recent Phase II trial underlines the efficacy and safety of defibrotide-thalidomide-melphalan combination in the treatment of relapsed/refractory multiple myeloma. Defibrotide may be effective in the prophylaxis and the treatment of veno-occlusive disease. Recent experimental results suggest that defibrotide may belong to the new generation of anti-cancer drugs that can prevent tumor angiogenesis. In multiple myeloma, defibrotide may overcome the prothrombotic effect of thalidomide on endothelial cells. Further preclinical and clinical investigations are needed to assess the precise role of defibrotide in the treatment of patients with multiple myeloma.

Embryotoxicita a indukce oxidativního stresu po exposici herbicidu paraquatu na modelovém necílovém organismu drápatce vodní (Xenopus laevis)

Czech Academy of Sciences Publication Activity Database

Pašková, Veronika; Hilscherová, Klára

2007-01-01

Roč. 43, č. 3 (2007), s. 107-112 ISSN 0007-389X. [Toxicita a biodegradabilita odpadů a látek významných ve vodním prostředí /13./. Vodňany, 18.06.2007-20.06.2007] R&D Projects: GA MŠk(CZ) 1M0571 Institutional research plan: CEZ:AV0Z60050516 Keywords : paraquat * oxidative stress * frogs Subject RIV: EF - Botanics

Evaluate the interactive and reusable service in adaptive on demand applications

OpenAIRE

Hwang , Chyi-Wen

2007-01-01

In this paper, the researcher based on the open platforms and tools for personalized learning idea, with the “ Interactive & reusable” function in UI design model, directly dealing with Knowledge on demand (KOD) service from the aspect-oriented and object-oriented issue. Moreover, to propose the KOD combine with VOD (Video on Demand); AOD (Audio on Demand); COD (Course on Demand) and IOD (Information on Demand in Global index searching) in diversity of hypermedia metadata.

Ovlivnění nutriční hodnoty svaloviny kapra obecného (Cyprinus carpio) a tolstolobika bílého ( Hypophthalmichtys molitrix) cyanobakteriemi

Czech Academy of Sciences Publication Activity Database

Palíková, M.; Mareš, J.; Pašková, Veronika; Kopp, R.; Adamovský, Ondřej; Hilscherová, Klára; Bláha, Luděk; Navrátil, S.

2007-01-01

Roč. 43, č. 3 (2007), s. 99-106 ISSN 0007-389X. [Toxicita a biodegradabilita odpadů a látek významných ve vodním prostředí /13./. Vodňany, 18.06.2007-20.06.2007] R&D Projects: GA MŠk(CZ) 1M0571 Institutional research plan: CEZ:AV0Z60050516 Keywords : cyanobacteria * bioindicators * nutritive value Subject RIV: EF - Botanics

A Concept of a Ship Domain for the Use of Navigational Safety Assessment / Analiza Bezpieczeństwa Morskiego z Wykorzystaniem Domeny Wokół Statku

Directory of Open Access Journals (Sweden)

Marcjan Krzysztof

2015-09-01

Full Text Available Jedną z ważniejszych koncepcji dotyczącej bezpieczeństwa nawigacji jest domena statku. Koncepcja morskiej domeny jest jedną z najstarszych domen, albowiem poprzedziła domeny stosowane w lotnictwie, branży kolejowej, przemyśle chemicznym oraz medycznym. Poprzez pojęcie domeny statku należy rozumieć pewien obszar wokół statku, który nawigator chciałby utrzymać wolnym od innych obiektów stałych i ruchomych. Sytuację nawigacyjną można uznać za bezpieczną tak długo, jak żaden inny statek lub przeszkoda nawigacyjna nie przekroczy tego obszaru. W celu budowy i rozwinięcia metody oceny bezpieczeństwa nawigacyjnego wyznaczono probabilistyczne domeny statku na podstawie danych z monitoringu AIS dla trzech typów sytuacji spotkaniowych między statkami. Celem pracy jest zaprezentowanie metody identyfikacji incydentów nawigacyjnych na podstawie domeny probabilistycznej, która może posłużyć do oceny bezpieczeństwa nawigacyjnego oraz odnajdywania miejsc potencjalnie niebezpiecznych na wybranych obszarach Morza Bałtyckiego.

Allogeneic Stem Cell Transplantation in Congenital Hemoglobinopathies Using a Tailored Busulfan-Based Conditioning Regimen: Single-Center Experience.

Science.gov (United States)

Zaidman, Irina; Rowe, Jacob M; Khalil, Abdalla; Ben-Arush, Myriam; Elhasid, Ronit

2016-06-01

Hematopoietic stem cell transplantation (HSCT) is the only proven curative option for patients with hemoglobinopathies, both thalassemia and sickle cell anemia (SCA). A busulfan-based myeloablative conditioning regimen is the standard of care for HSCT in these patients, although increased treatment-related morbidity, including veno-occlusive disease (VOD), has been demonstrated. Thirty-eight pediatric patients, median age 8 years (range, 6 months to 22 years), suffering from hemoglobinopathy were treated at Rambam Medical Center in Haifa, Israel, between 1998 and 2011. Thirty-four patients had thalassemia major and 4 had SCA. The 38 patients underwent 40 HSCTs, 34 of which were first transplants and 6 second transplants. Most transplants (32/40) were from matched sibling donors. Sources of stem cells were peripheral blood in 30 transplants, bone marrow in 7 transplants, and cord blood in 3 transplants. All received different customized busulfan-based conditioning regimens tailored by pharmacokinetic analysis of busulfan levels. Primary engraftment occurred in 37 of 40 transplants. Neutrophil engraftment (>.5 × 10(9)/L) occurred at a median of 15.3 days post-transplantation (range, 10 to 45). Platelet transfusion independence (>20 × 10(9)/L) occurred at a median of 22.3 days (range, 11 to 60). The rate of 5-year overall survival for thalassemia patients after first transplantation was 90.5% ± 5.3%. The rate of 5-year thalassemia-free survival was 81.7% ± 6.8%. Cumulative incidence of acute graft-versus-host disease (GVHD) was 17.6%. Rate of grades III to IV GVHD was 8.8%. Cumulative incidence of chronic GVHD was 23.5%, with 11.8% incidence of extensive chronic GVHD. One patient developed VOD. Full donor chimerism occurred in 36.4% of patients with class 1 + 2 thalassemia, compared with 78.6% in class 3 thalassemia (P = .049). Overall survival above 90% in patients undergoing their first transplant was demonstrated using busulfan

Metodika a výsledky dlouhodobého seismického Monitoringu na PZP Háje – Innogy.cz

Czech Academy of Sciences Publication Activity Database

Brož, Milan; Štrunc, J.

2017-01-01

Roč. 24, č. 1 (2017), s. 1-11 ISSN 1803-1447 Institutional support: RVO:67985530 Keywords : granit * earthquake * induced seismicity * seismograph * frequency spectra Subject RIV: DC - Siesmology, Volcanology, Earth Structure OBOR OECD: Volcanology

A Client-Server System for Ubiquitous Video Service

Directory of Open Access Journals (Sweden)

Ronit Nossenson

2012-12-01

Full Text Available In this work we introduce a simple client-server system architecture and algorithms for ubiquitous live video and VOD service support. The main features of the system are: efficient usage of network resources, emphasis on user personalization, and ease of implementation. The system supports many continuous service requirements such as QoS provision, user mobility between networks and between different communication devices, and simultaneous usage of a device by a number of users.

Packet-aware transport for video distribution [Invited

Science.gov (United States)

Aguirre-Torres, Luis; Rosenfeld, Gady; Bruckman, Leon; O'Connor, Mannix

2006-05-01

We describe a solution based on resilient packet rings (RPR) for the distribution of broadcast video and video-on-demand (VoD) content over a packet-aware transport network. The proposed solution is based on our experience in the design and deployment of nationwide Triple Play networks and relies on technologies such as RPR, multiprotocol label switching (MPLS), and virtual private LAN service (VPLS) to provide the most efficient solution in terms of utilization, scalability, and availability.

Akumulace a eliminace microcystinů v rybách (Cyprinus carpio, Hypophthalmichthys molitrix) a hodnocení biomarkerů po expozici sinicovou biomasou

Czech Academy of Sciences Publication Activity Database

Adamovský, Ondřej; Kopp, Radovan; Hilscherová, Klára; Palíková, M.; Navrátil, S.; Bláha, Luděk

2007-01-01

Roč. 43, č. 3 (2007), s. 4-8 ISSN 0007-389X. [Toxicita a biodegradabilita odpadů a látek významných ve vodním prostředí /13./. Vodňany, 18.06.2007-20.06.2007] R&D Projects: GA MŠk(CZ) 1M0571 Grant - others:MZE(CZ) QH71015 Institutional research plan: CEZ:AV0Z60050516 Keywords : cyanotoxins * water blooms * toxicity Subject RIV: EF - Botanics

Původ nové ekonomické elity po roce 1989

Czech Academy of Sciences Publication Activity Database

Bayer, Ivo; Šafr, Jiří

2009-01-01

Roč. 7, č. 6 (2009), s. 6-9 ISSN 1214-1720 R&D Projects: GA MŠk 2D06014 Institutional research plan: CEZ:AV0Z70280505 Keywords : economic elites Subject RIV: AO - Sociology, Demography http://www.socioweb.cz/upl/editorial/download/167_socioweb_06_09.pdf

Jednoduchý návod ke sběru prachu

Czech Academy of Sciences Publication Activity Database

Hladil, Jindřich; Kondziolka, J.

2008-01-01

Roč. 12, 712. (2008), s. 1-9 ISSN 1212-6691 R&D Projects: GA AV ČR IAAX00130702 Institutional research plan: CEZ:AV0Z30130516 Keywords : dustfall * eolian sediment * sampling techniques Subject RIV: DB - Geology ; Mineralogy http://www.ian.cz/detart_fr.php?id=2808

Integrated multimedia information system on interactive CATV network

Science.gov (United States)

Lee, Meng-Huang; Chang, Shin-Hung

1998-10-01

In the current CATV system architectures, they provide one- way delivery of a common menu of entertainment to all the homes through the cable network. Through the technologies evolution, the interactive services (or two-way services) can be provided in the cable TV systems. They can supply customers with individualized programming and support real- time two-way communications. With a view to the service type changed from the one-way delivery systems to the two-way interactive systems, `on demand services' is a distinct feature of multimedia systems. In this paper, we present our work of building up an integrated multimedia system on interactive CATV network in Shih Chien University. Besides providing the traditional analog TV programming from the cable operator, we filter some channels to reserve them as our campus information channels. In addition to the analog broadcasting channel, the system also provides the interactive digital multimedia services, e.g. Video-On- Demand (VOD), Virtual Reality, BBS, World-Wide-Web, and Internet Radio Station. These two kinds of services are integrated in a CATV network by the separation of frequency allocation for the analog broadcasting service and the digital interactive services. Our ongoing work is to port our previous work of building up a VOD system conformed to DAVIC standard (for inter-operability concern) on Ethernet network into the current system.

Una versión de la distribución Rayleigh generalizada transmutada

Directory of Open Access Journals (Sweden)

Yuri A. Iriarte

2015-06-01

Full Text Available La calidad de los procedimientos utilizados en un análisis estadístico depende en gran medida del modelo o las distribuciones de probabilidad que se emplean. Debido a esto, diversos autores han realizado un esfuerzo considerable en generalizar o extender distribuciones de probabilidad presentes en la literatura estadística. En este contexto, Vodă en [13] introduce la distribución de probabilidad Rayleigh generalizada; esta distribución es bastante utilizada en el análisis estadístico de confiabilidad. En este artículo extendemos la distribución Rayleigh generalizada usando el mapa de transmutación de rango cuadrático estudiado por Shaw y Buckley en [12]. Estudiamos las principales propiedades del nuevo modelo, realizamos inferencia estadística y mostramos una aplicación con datos reales. Finalmente, se presentan las principales conclusiones del artículo. Abstract. Statistical analysis procedures’s quality depends on the proper use of the probability distributions. For that reason, many probability distributions have been generalized. For example, Vodă in [13] introduced the generalized Rayleigh distribution, a model widely used in reliability analysis. In this article, we introduce an extension of the generalized Rayleigh distribution using the quadratic rank transmutation map studied by Shaw and Buckley in [12]. We study t

Angiogenesis alteration by defibrotide: implications for its mechanism of action in severe hepatic veno-occlusive disease.

Science.gov (United States)

Benimetskaya, Luba; Wu, Sijian; Voskresenskiy, Anatoliy M; Echart, Cinara; Zhou, Jin-Feng; Shin, Joongho; Iacobelli, Massimo; Richardson, Paul; Ayyanar, Kanyalakshmi; Stein, C A

2008-11-15

Defibrotide (DF) is a mixture of porcine-derived single-stranded phosphodiester oligonucleotides (9-80-mer; average, 50-mer) that has been successfully used to treat severe hepatic veno-occlusive disease (sVOD) with multiorgan failure (MOF) in patients who have received cytotoxic chemotherapy in preparation for bone marrow transplantation. However, its mechanism of action is unknown. Herein, we show that DF and phosphodiester oligonucleotides can bind to heparin-binding proteins (eg, basic fibroblast growth factor [bFGF] but not vascular endothelial growth factor [VEGF] 165) with low nanomolar affinity. This binding occurred in a length- and concentration-dependent manner. DF can mobilize proangiogenic factors such as bFGF from their depot or storage sites on bovine corneal endothelial matrix. However, these molecules do not interfere with high-affinity binding of bFGF to FGFR1 IIIc but can replace heparin as a required cofactor for binding and hence cellular mitogenesis. DF also protects bFGF against digestion by trypsin and chymotrypsin and from air oxidation. In addition, DF binds to collagen I with low nanomolar affinity and can promote human microvascular endothelial cell-1 (HMEC-1) cell mitogenesis and tubular morphogenesis in three-dimensional collagen I gels. Thus, our data suggest that DF may provide a stimulus to the sinusoidal endothelium of a liver that has suffered a severe angiotoxic event, thus helping to ameliorate the clinical sVOD/MOF syndrome.

Využití umělých a poloumělých výtěrů v současném chovu kapra

OpenAIRE

MARKOVÁ, Aneta

2014-01-01

This thesis is focused on the use of artificial and semi-artificial spawning substrates in the current breeding of common carp (Cyprinus carpio, L.) a literature review of this species was processed in relation to reproduction, as well as of the spawning methods (natural, semi-artificial, artificial). Results are drawn from the experimental part (2 spawns: a semi-artificial spawn in the institution for experiments at the Fishery School in Vodňany and an artificial spawn in the fish hatchery a...

Fish occurrence in the fishpass on the lowland section of the River Elbe, Czech Republic, with respect to water temperature, water flow and fish size

Czech Academy of Sciences Publication Activity Database

Prchalová, Marie; Horký, P.; Slavík, O.; Vetešník, Lukáš; Halačka, Karel

2011-01-01

Roč. 60, č. 2 (2011), s. 104-114 ISSN 0139-7893. [Česká ichtyologická konference /12./. Vodňany, 19.05.2010-20.05.2010] R&D Projects: GA AV ČR(CZ) 1QS500450513 Institutional research plan: CEZ:AV0Z60170517; CEZ:AV0Z60930519 Keywords : migration * fish * water flow * water temperature * fishpass Subject RIV: DA - Hydrology ; Limnology Impact factor: 0.554, year: 2011 http://www.ivb.cz/folia/60/2/050-2010.pdf

Pracovní plodnost mlíčáků jesetera malého v provozních podmínkách českých chovů

OpenAIRE

SCHACHERLOVÁ, Jiřina

2015-01-01

Currently, fish fertility studies are mainly focused on female fertility. Studies showing fertility of male fish of any kind are missing to a large extent. The main objective of my thesis was to identify what level of fertility is achieved by male sterlet (Acipenser ruthenus) in the conditions of fish farming in the Czech Republic. Male fish from the Vodňany farm where the raised population comes from Russia was compared to male fish from Pohořelice where the raised population comes from Danu...

Global-scale assessment and combination of SMAP with ASCAT (active) and AMSR2 (passive) soil moisture products

Science.gov (United States)

Kim, Hyunglok; Parinussa, Robert; Konings, Alexandra G.; Wagner, Wolfgang; Cosh, Michael H.; Lakshmi, Venkat; Zohaib, Muhammad; Choi, Minha

2018-01-01

Global-scale surface soil moisture (SSM) products retrieved from active and passive microwave remote sensing provide an effective method for monitoring near-real-time SSM content with nearly daily temporal resolution. In the present study, we first inter-compared global-scale error patterns and combined the Soil Moisture Active Passive (SMAP), Advanced Scatterometer (ASCAT), and Advanced Microwave Scanning Radiometer 2 (AMSR2) SSM products using a triple collocation (TC) analysis and the maximized Pearson correlation coefficient (R) method from April 2015 to December 2016. The Global Land Data Assimilation System (GLDAS) and global in situ observations were utilized to investigate and to compare the quality of satellite-based SSM products. The average R-values of SMAP, ASCAT, and AMSR2 were 0.74, 0.64, and 0.65 when they compared with in situ networks, respectively. The ubRMSD values were (0.0411, 0.0625, and 0.0708) m3 m- 3; and the bias values were (- 0.0460, 0.0010, and 0.0418) m3 m- 3 for SMAP, ASCAT, and AMSR2, respectively. The highest average R-values from SMAP against the in situ results are very encouraging; only SMAP showed higher R-values than GLDAS in several in situ networks with low ubRMSD (0.0438 m3 m- 3). Overall, SMAP showed a dry bias (- 0.0460 m3 m- 3) and AMSR2 had a wet bias (0.0418 m3 m- 3); while ASCAT showed the least bias (0.0010 m3 m- 3) among all the products. Each product was evaluated using TC metrics with respect to the different ranges of vegetation optical depth (VOD). Under vegetation scarce conditions (VOD 0.40) ASCAT showed comparatively better performance than did the other products. Using the maximized R method, SMAP, ASCAT, and AMSR2 products were combined one by one using the GLDAS dataset for reference SSM values. When the satellite products were combined, R-values of the combined products were improved or degraded depending on the VOD ranges produced, when compared with the results from the original products alone. The

Enhancing Scalability in On-Demand Video Streaming Services for P2P Systems

Directory of Open Access Journals (Sweden)

R. Arockia Xavier Annie

2012-01-01

Full Text Available Recently, many video applications like video telephony, video conferencing, Video-on-Demand (VoD, and so forth have produced heterogeneous consumers in the Internet. In such a scenario, media servers play vital role when a large number of concurrent requests are sent by heterogeneous users. Moreover, the server and distributed client systems participating in the Internet communication have to provide suitable resources to heterogeneous users to meet their requirements satisfactorily. The challenges in providing suitable resources are to analyze the user service pattern, bandwidth and buffer availability, nature of applications used, and Quality of Service (QoS requirements for the heterogeneous users. Therefore, it is necessary to provide suitable techniques to handle these challenges. In this paper, we propose a framework for peer-to-peer- (P2P- based VoD service in order to provide effective video streaming. It consists of four functional modules, namely, Quality Preserving Multivariate Video Model (QPMVM for efficient server management, tracker for efficient peer management, heuristic-based content distribution, and light weight incentivized sharing mechanism. The first two of these modules are confined to a single entity of the framework while the other two are distributed across entities. Experimental results show that the proposed framework avoids overloading the server, increases the number of clients served, and does not compromise on QoS, irrespective of the fact that the expected framework is slightly reduced.

Design definition study of a lift/cruise fan technology V/STOL aircraft. Volume 1: Navy operational aircraft

Science.gov (United States)

1975-01-01

Aircraft were designed and sized to meet Navy mission requirements. Five missions were established for evaluation: anti-submarine warfare (ASW), surface attack (SA), combat search and rescue (CSAR), surveillance (SURV), and vertical on-board delivery (VOD). All missions were performed with a short takeoff and a vertical landing. The aircraft were defined using existing J97-GE gas generators or reasonable growth derivatives in conjunction with turbotip fans reflecting LF460 type technology. The multipurpose aircraft configuration established for U.S. Navy missions utilizes the turbotip driven lift/cruise fan concept for V/STOL aircraft.

Photonometers for coating and sputtering machines

Science.gov (United States)

Oupický, P.; Jareš, D.; Václavík, J.; Vápenka, D.

2013-04-01

The concept of photonometers (alternative name of optical monitor of a vacuum deposition process) for coating and sputtering machines is based on photonometers produced by companies like SATIS or HV Dresden. Photometers were developed in the TOPTEC centre and its predecessor VOD (Optical Development Workshop of Institut of Plasma Physics AS CR) for more than 10 years. The article describes current status of the technology and ideas which will be incorporated in next development steps. Hardware and software used on coating machines B63D, VNA600 and sputtering machine UPM810 is presented.

Fosfor v odpadních vodách - perspektivy jeho recyklace

Czech Academy of Sciences Publication Activity Database

Holba, M.; Došek, M.; Maršálek, Blahoslav

2015-01-01

Roč. 65, č. 4 (2015), s. 8-12 ISSN 1211-0760 R&D Projects: GA MZe(CZ) QJ1320234 Institutional support: RVO:67985939 Keywords : phosphorus recycling * wastewater * fertilizer * technology Subject RIV: DJ - Water Pollution ; Quality

O povaze morálních důvodů

Czech Academy of Sciences Publication Activity Database

Sobek, Tomáš

2012-01-01

Roč. 4, č. 2 (2012), s. 5-18 ISSN 1804-0969 R&D Projects: GA ČR GAP408/12/2579 Institutional support: RVO:68378122 Keywords : theory of law * philosophy of law * ethics Subject RIV: AG - Legal Sciences http://hdl.handle.net/11104/0216879

Úvod do problematiky "wrongful birth" a "wrongful life" žalob

Czech Academy of Sciences Publication Activity Database

Doležal, Tomáš

2013-01-01

Roč. 3, č. 3 (2013), s. 4-12 ISSN 1804-8137 Institutional support: RVO:68378122 Keywords : wrongful life * wrongful conception * wrongful birth Subject RIV: AG - Legal Sciences http://www.ilaw.cas.cz/medlawjournal/index.php/medlawjournal/article/view/55

Úvod. Setkání s Bedřichem Loewensteinem

Czech Academy of Sciences Publication Activity Database

Hermann, Tomáš

2009-01-01

Roč. 6, č. 2 (2009), s. 253-256 ISSN 1214-7249. [Dějiny víry v pokrok. Praha, 16.06.2009 -] R&D Projects: GA AV ČR IAAX00630801 Institutional research plan: CEZ:AV0Z80630520 Keywords : Bedřich Loewenstein * faith in progress * history of ideas Subject RIV: AB - History

Dekontaminace důlních vod bohatých arzenem

OpenAIRE

Řáhová, Jaroslava

2014-01-01

Summary: This bachalor thesis deals with treatment of mine waters rich in arsenic. First part is an overview of decontamination methods used for elimination of arsenic from water. Emphasised parts are focused on arsenic adsorption on Fe-oxides and hydroxides, particles which may be formed in mine waters; as well as on ODAS treatment system, widely used for mine waters decontamination. The experimental part is a study of decontamination process at mine treatment plant waters in Kaňk, Kutná hor...

The application and implementation of optimized mine ventilation on demand (OMVOD) at the Xstrata Nickel Rim South Mine, Sudbury, Ontario

International Nuclear Information System (INIS)

Bartsch, E.; Laine, M.; Andersen, M.

2010-01-01

An Optimized Mine Ventilation on Demand (OMVOD) system has been installed at the Xstrata Nickel Rim South Mine in Sudbury. Developed by Simsmart Technologies, the OMVOD system monitors and controls air quality and quantity through real time dynamic automation. A ventilation on demand (VOD) system was needed to remove diesel particulate matter (DPM), carbon monoxide (CO) and nitrogen dioxide (NO 2 ). This paper described the real-time tracking and monitoring of the OMVOD system and optimization of ventilation equipment. Simsmart's OMVOD system was shown to reduce energy costs while improve air quality in the underground mine. 7 refs., 3 tabs., 8 figs.

Photonometers for coating and sputtering machines

Directory of Open Access Journals (Sweden)

Václavík J.

2013-05-01

Full Text Available The concept of photonometers (alternative name of optical monitor of a vacuum deposition process for coating and sputtering machines is based on photonometers produced by companies like SATIS or HV Dresden. Photometers were developed in the TOPTEC centre and its predecessor VOD (Optical Development Workshop of Institut of Plasma Physics AS CR for more than 10 years. The article describes current status of the technology and ideas which will be incorporated in next development steps. Hardware and software used on coating machines B63D, VNA600 and sputtering machine UPM810 is presented.

Vodú Chic: Haitian Religion and the Folkloric Imaginary in Socialist Cuba

Directory of Open Access Journals (Sweden)

Grete Viddal

2012-12-01

Full Text Available During the first three decades of the twentieth century, hundreds of thousands of Haitian agricultural laborers arrived in Cuba seeking employment in the expanding sugar industry. Historically, Haitian cane cutters were marginal and occupied the lowest socio-economic status in Cuban society. Until relatively recently, the maintenance of Haitian spiritual beliefs, music, dance, and language in Cuba were associated with rural isolation and poverty. Today however, the continuation of Haitian customs is no longer linked with isolation, but exactly the opposite: performance troupes, heritage festivals, art exhibitions, the circulation of religious specialists, collaborations with research centers and academia, endorsement by music promoters, and the tourism industry. Cubans of Haitian heritage have found innovative ways to transform the abject into the exotic, and are currently gaining a public voice in cultural production, particularly through folkloric performance.

Sorpce cytostatik platinové řady z odpadních vod nemocnic.

Czech Academy of Sciences Publication Activity Database

Wittlingerová, A.; Zimová, M.; Cidlinová, A.; Petruželová, A.; Matějková, Martina; Šolcová, Olga

2016-01-01

Roč. 110, č. 7 (2016), s. 511-516 ISSN 0009-2770 Institutional support: RVO:67985858 Keywords : Pt group cytostatics * hazards * contamination Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 0.387, year: 2016

Problematika migrace z environmentálních důvodů

OpenAIRE

Dvorská, Eliška

2013-01-01

Many people worldwide are forced to leave their homes because of serious degradation of environmental conditions, natural disasters and depletion of natural resources. Growing impacts of climate change and global warming on the environment and human mobility are becoming increasingly worrying, creating a need for protection of those environmentally displaced persons. Although there has been a great attention paid to this phenomenon, the category of so-called "environmental refugees" still con...

Optimizing cast blasting efficiency using ANFO with liners

Energy Technology Data Exchange (ETDEWEB)

Madsen, A.

2007-01-15

As part of a five research project funded by the National Science Foundation, Peabody Energy studied three experimental cast blasts conducted at the North Antelope Rochelle mine site on July 24,28 and 31 2005. The initial purpose of this research project was to determine the influence that blast initiation sequence have on: NOx production; Face Displacement; Highwall damage; Explosive performance; Vibration emissions; Displacement; Surface swell; and Cast benefit. Two new discoveries on velocity of detonation (VoD) and pressure of detonation (PoD) were made as a result of this research project. Furthermore, a relationship between surface swell velocity and face velocity was also noted. 7 figs., 3 tabs.

La televisión de alta definición

Directory of Open Access Journals (Sweden)

Carlos Eduardo Cortés S.

2014-12-01

Full Text Available Establece la relación del iPod con la televisión digital(DTV y la televisión de alta definición (HDTVque produce una percepción de profundidad con apariencia tridimensional. El nuevo iPod podría convertirse en un eslabón en las nuevas formas de consumo de video digital. El pronóstico de este estudio para el mercado DTV en los Estados Unidos indica que, cuando a fines de la presente década, la mitad de los hogares con televisor estará usando servicios avanzados de televisión como el VOD y las funciones de DVR.

Soil moisture extremes drive tree canopy death in 2011 Texas drought: multispectral (Landsat, NAIP) and L-band passive microwave remote sensing (SMOS-IC)

Science.gov (United States)

Swenson, J. J.; Schwantes, A. M.; Johnson, D. M.; Domec, J. C.; Wigneron, J. P.

2017-12-01

Climate change is bringing more frequent and intense droughts that are causing broad scale tree mortality events. Detecting regional drought stress is now more frequently monitored with passive microwave satellite sensing of soil moisture (SM) and vegetation water status (through the vegetation optical depth (VOD) index), that can be validated with in-situ measurements of soil moisture or corroborated with satellite multispectral indices of greenness. The detection of canopy death however marks the passing of a definitive physiological threshold. We compare soil moisture from the L-band SMOS-IC passive microwave product (2010-20176) to an accurate and detailed (30-m spatial resolution) map of canopy loss across the US state of Texas during the record breaking 2011 drought. The SMOS-IC product (25 km) is a new and simpler product of soil moisture and VOD that has been shown to be more accurate than past SMOS products and it is independent of ancillary data. Canopy loss was mapped from Landsat imagery trained with 186, 41 km2 subplots of classified National Agriculture Inventory Program color infrared aerial imagery recorded before and after the drought. Bringing these two datasets of disparate spatial resolution together and averaging them across the state, we find that areas with at least 25% tree cover that experienced the most canopy loss (highest quartile) had lower soil moisture compared to areas with less canopy loss in 2011. These areas with the most loss, experienced up to 9 weeks of the growing season at stress as well as the effects of topography, soil, and climate. Having more information on plant hydraulic limits would lend itself to modeling and prediction of die offs based on satellite tracked SM.

Post-transplant outcome in chronic myeloid leukemia

International Nuclear Information System (INIS)

Raza, S.; Ullah, K.; Ahmed, P.; Kamal, M.K.

2008-01-01

To determine post-transplant survival in chronic myeloid leukaemia patients undergoing allogeneic stem cell transplant. All patients of chronic myeloid leukaemia in chronic phase having HLA identical donor and age under 55 years, normal hepatic, renal and cardiac functions with good performance status were selected. Patients in accelerated phase or blast crisis, poor performance status, impaired hepatic, renal, cardiac functions or pregnancy were excluded. Survival was calculated from the date of transplant to death or last follow-up according to Kaplan-Meier and Cox (proportional hazard) regression analysis methods. Thirty seven patients with chronic myeloid leukaemia underwent allogeneic stem cell transplant from HLA identical sibling donors. Thirty two patients were male and five were females. Median age of patients was 28 years. All patients and donors were CMV positive. Post-transplant complications encountered were acute GvHD (Grade II-IV) (n=13, 35.1%), chronic GvHD in 18.9% (n=7), Veno Occlusive Disease (VOD) in 5.4% (n=2), acute renal failure in 2.7% (n=1), haemorrhagic cystitis in 2.7% (n=1), bacterial infections in 40.5% (n=15), fungal infections in 16.2% (n=6), CMV infection in 5.4% (n=2), tuberculosis in 5.4% (n=2), Herpes Zoster infection 2.7% (n=1) and relapse in 2.7% (n=1). Mortality was observed in 27% (n=10). Major causes of mortality were GvHD, VOD, septicemia, CMV infection and disseminated Aspergillosis. Overall Disease Free Survival (DFS) was 73% with a median duration of follow-up of 47.4 + 12 months. DFS was 81% in standard risk and 54.5% in high-risk group. Results of allogeneic stem cell transplant in standard risk group CML patients were good and comparable with other international centres, however, results in high-risk CML patients need further improvement, although, number of patients in this group is small. (author)

Renal toxicity in children undergoing total body irradiation for bone marrow transplant

International Nuclear Information System (INIS)

Esiashvili, Natia; Chiang, K.-Y.; Hasselle, Michael D.; Bryant, Cynthia; Riffenburgh, Robert H.; Paulino, Arnold C.

2009-01-01

Purpose: Contribution of total body irradiation (TBI) to renal toxicity in children undergoing the bone marrow transplant (BMT) remains controversial. We report our institutional retrospective study that evaluates the frequency of acute and chronic renal dysfunction in children after using total body irradiation (TBI) conditioning regimens. Materials and methods: Between 1995 and 2003, 60 children with hematological malignancies underwent TBI as part of a conditioning regimen before allogeneic BMT. Patients received 4-14 Gy at 1.75-2 Gy/fraction in six-eight fractions. Lung shielding was used in all patients to limit lung dose to less than 10 Gy; renal shielding was not utilized. All patients had baseline renal function assessment and renal dysfunction post-BM was mainly evaluated on the basis of persistent serum creatinine elevation at acute (0-90 days) and chronic (>90 days) intervals after completion of BMT. Results: Acute renal dysfunction (ARD) was documented in 27 patients (45%); the majority had concurrent diagnosis of veno-occlusive disease (VOD) or graft-versus-host disease (GVHD) and other potential causes (sepsis, antibiotic). The risk for delayed renal dysfunction (DRD) at 1 year approached 25% for surviving patients. The ARD was strongly linked with the risk of the DRD. There was no statistically significant relationship between ARD, DRD and underlying diagnosis, GVHD, VOD or TBI doses with both univariate and multivariate analyses. The younger age (<5 years) had significantly increased risk for the development of ARD (p = 0.011). Conclusion: Our analysis validates high incidence of renal dysfunction in the pediatric BMT population. In contrast to other reports we did not find total body irradiation dose to be a risk factor for renal dysfunction. Future prospective studies are needed to assess risk factors and interventions for this serious toxicity in children following allogeneic BM

Design issues and caching strategies for CD-ROM-based multimedia storage

Science.gov (United States)

Shastri, Vijnan; Rajaraman, V.; Jamadagni, H. S.; Venkat-Rangan, P.; Sampath-Kumar, Srihari

1996-03-01

CD-ROMs have proliferated as a distribution media for desktop machines for a large variety of multimedia applications (targeted for a single-user environment) like encyclopedias, magazines and games. With CD-ROM capacities up to 3 GB being available in the near future, they will form an integral part of Video on Demand (VoD) servers to store full-length movies and multimedia. In the first section of this paper we look at issues related to the single- user desktop environment. Since these multimedia applications are highly interactive in nature, we take a pragmatic approach, and have made a detailed study of the multimedia application behavior in terms of the I/O request patterns generated to the CD-ROM subsystem by tracing these patterns. We discuss prefetch buffer design and seek time characteristics in the context of the analysis of these traces. We also propose an adaptive main-memory hosted cache that receives caching hints from the application to reduce the latency when the user moves from one node of the hyper graph to another. In the second section we look at the use of CD-ROM in a VoD server and discuss the problem of scheduling multiple request streams and buffer management in this scenario. We adapt the C-SCAN (Circular SCAN) algorithm to suit the CD-ROM drive characteristics and prove that it is optimal in terms of buffer size management. We provide computationally inexpensive relations by which this algorithm can be implemented. We then propose an admission control algorithm which admits new request streams without disrupting the continuity of playback of the previous request streams. The algorithm also supports operations such as fast forward and replay. Finally, we discuss the problem of optimal placement of MPEG streams on CD-ROMs in the third section.

Optimization of mine ventilation fan speeds according to ventilation on demand and time of use tariff

International Nuclear Information System (INIS)

Chatterjee, Arnab; Zhang, Lijun; Xia, Xiaohua

2015-01-01

Highlights: • DSM techniques are applied to an underground mine ventilation network. • A minimization model is solved to find the optimal speeds of the main mine fan. • Ventilation on demand (VOD) leads to a saving of USD 213160. • The optimal mining schedule, together with VOD, leads to a saving of USD 277035. • According to a case study, a maximum of 2 540 035 kW h can be saved per year. - Abstract: In the current situation of the energy crisis, the mining industry has been identified as a promising area for application of demand side management (DSM) techniques. This paper investigates the potential for energy-cost savings and actual energy savings, by implementation of variable speed drives to ventilation fans in underground mines. In particular, ventilation on demand is considered in the study, i.e., air volume is adjusted according to the demand at varying times. Two DSM strategies, energy efficiency (EE) and load management (LM), are formulated and analysed. By modelling the network with the aid of Kirchhoff’s laws and Tellegen’s theorem, a nonlinear constrained minimization model is developed, with the objective of achieving EE. The model is also made to adhere to the fan laws, such that the fan power at its operating points is found to achieve realistic results. LM is achieved by finding the optimal starting time of the mining schedule, according to the time of use (TOU) tariff. A case study is shown to demonstrate the effects of the optimization model. The study suggests that by combining load shifting and energy efficiency techniques, an annual energy saving of 2 540 035 kW h is possible, leading to an annual cost saving of USD 277035

Příprava na nejdelší triatlonový závod Ironman

OpenAIRE

Mika, Tomáš

2012-01-01

Preparing for the longest race Ironman Triathlon This thesis deals with the preparation for the longest race Triathlon - Ironman. The theoretical part of the work includes chapters on the history and current long distance triathlon. It also deals with the specifics of the sport and the different disciplines(swimming, cycling, running). The research part is composed of the experiment, evaluation of the data and subsequent analysis. The work implies that in the performance of individual council...

Příprava na nejdelší triatlonový závod (Ironmana)

OpenAIRE

Mika, Tomáš

2011-01-01

Triathlon is still a popular sport that is gaining more and morepopular. We distinguish two basic directions. Short, or if the Olympictriathlon and long, or if Ironman. In my work I examine the long triathlon. Its history, training cycle and its specifics. I myself an active rider, so this issue is very close to me. I work divided into a theoretical part, where I deal with theories and general laws of triathlon. Such as history, specifics of Ironman training and unit training cycle discipline...

Pozdrav v indoevropském areálu (původ, motivace, funkce)

Czech Academy of Sciences Publication Activity Database

Karlíková, Helena

2016-01-01

Roč. 77, č. 4 (2016), s. 337-353 ISSN 0037-7031 R&D Projects: GA ČR(CZ) GA13-17435S Institutional support: RVO:68378092 Keywords : Indo-European * greetings * etymology * semantics Subject RIV: AI - Linguistics Impact factor: 0.625, year: 2016

Optimization of monitoring sewage with radionuclide contaminants. Optimizatsiya kontroya stochnykh vod, zagryaznennykh radionuklidami

Energy Technology Data Exchange (ETDEWEB)

Egorov, V N [Vsesoyuznyj Nauchno-Issledovatel' skij Inst. Neorganicheskikh Materialov, Moscow (Russian Federation)

1991-03-01

Recommendations on optimization of monitoring contaminated sewage aimed at enviromental protection agxinst radioactive contamination at minimum cost are presented. The way of selecting water sampling technique depends on water composition stability and flow rate. Depending on the type of radionuclide distribution in the sewage one can estimate minimum frequency of sampling or number of samples sufficient for assuring reliability of the conclusion on the excess or non-excess of permissible radioactive contamination levels, as well as analysis assigned accuracy. By irregular contaminated sewage-discharge and possibility of short-term releases of different form and duration, sampling should be accomplished through automatic devices of continuons or periodic operation.

Původ obsidiánové suroviny v pravěku Čech

Czech Academy of Sciences Publication Activity Database

Burgert, Pavel; Přichystal, A.; Prokeš, L.; Petřík, J.; Hušková, S.

2016-01-01

Roč. 68, č. 2 (2016), s. 224-234 ISSN 0323-1267 R&D Projects: GA ČR GA15-16963S Institutional support: RVO:67985912 Keywords : chipped industry * obsidian * Bohemia * Neolithic * Upper Palaeolithic * geochemistry * provenance Subject RIV: AC - Archeology, Anthropology, Ethnology

Doping ve fitness a rekreační sport : obsahová analýza českých videí na YouTube

OpenAIRE

Miček, Jakub

2016-01-01

Bibliografický záznam MIČEK, Jakub. Doping ve fitness a rekreační sport: obsahová analýza českých videí na YouTube. Praha, 2016. 48 s. Bakalářská práce (Bc.) Univerzita Karlova. Fakulta sociálních věd, Institut sociologických důvodů. Katedra sociologie. Vedoucí bakalářské práce PhDr. Mgr. Jan Balon, Ph.D. Abstract Fitness and YouTube are very popular areas of entertainment these days. Despite the touchiness of this topic, there are many videos about doping being published on YouTube. Majority...

Využití regulačních diagramů pro kontrolu jakosti

OpenAIRE

Ječmínková, Michaela

2014-01-01

Diplomová práce se zaměřuje na využití Shewhartových regulačních diagramů pro kontrolu jakosti. Práce popisuje současný proces kontroly kvality v podniku a následně poskytuje praktický návod zavedení statistické regulace procesu kontroly jakosti vybraného komponentu a hodnocení způsobilosti. Součástí práce je také aplikace pro tvorbu regulačních diagramů a průběžnou kontrolu jakosti daného výrobku. This diploma thesis deals with use of Shewhart Control Charts in quality control. The thesis...

LABORATORYJNA INSTALACJA FOTOWOLTAICZNA Z MAGAZYNEM ENERGII

Directory of Open Access Journals (Sweden)

Adam MROZIŃSKI

Full Text Available W artykule przedstawiono zagadnienie wykorzystania w Polsce i w Europie instalacji fotowoltaicznych (PV z magazynami energii elektrycznej. Systemy PV będą miały w niedalekiej przyszłości znaczny udział w globalnej produkcji energii elektrycznej. Będzie to istotnie wpływało na ograniczenie emisji gazów cieplarnianych oraz na poprawę stanu środowiska naturalnego. W pracy przedstawiono budowę laboratoryjnej instalacji PV zlokalizowanej na WIM UTP w Bydgoszczy. Przedstawiono również wybrane wyniki pomiarów rozkładu produkcji i dystrybucji energii elektrycznej w czasie (produkcja przez układ PV, zużycie własne, magazynowanie w akum, przesył do sieci zewn. z wykorzystaniem systemu monitoringu. W instalacjach PV coraz większe znaczenie mają systemy zarządzania energią oraz układy magazynujące energię elektryczną. Dzięki tym systemom energia elektryczna produkowana w ciągu dnia będzie zużywana na bieżąco. Nadmiar energii trafi do przydomowego akumulatora. Zgromadzona energia efektywnie zostanie wykorzystana wieczorem, kiedy zapotrzebowanie na prąd jest najwyższe. Ewentualne niedobory pokryje energia z sieci - kupiona nocą lub wczesnym rankiem, kiedy cena energii jest najniższa. Inteligentne sieci przesyłowe współpracujące z przydomowymi instalacjami PV z magazynami energii umożliwią skuteczniejsze zarządzanie popytem i podażą energii w całym systemie energetycznym.

Monitoring of spotted eagles in Estonia in 1994–2014: Stability of the lesser spotted eagle (Aquila pomarina and decline of the greater spotted eagle (A. clanga

Directory of Open Access Journals (Sweden)

Väli Ülo

2015-06-01

Full Text Available Populacné trendy orla kriklavého a hrubozobého v Estónsku boli odhadnuté z údajov získaných v rokoch 1994 - 2014 v rámci monitoringu bežných druhov dravcov a tiež zo špeciálnych plôch na monitoring týchto dvoch druhov orlov. Oba metodické prístupy majú svoje klady a zápory, avšak z ich údajov vypocítané populacné trendy sú si podobné. Pocetnost orla kriklavého v posledných dvoch desatrociach mierne kolísala, celkový trend je ale stabilný; velkost jeho populácie sa v súcasnosti odhaduje na 600 - 700 párov. Pocet hniezdnych teritórií orla hrubozobého (cisté aj zmiešané páry významne poklesol, napr. v rokoch 2004 až 2010 o 14 % za rok, v posledných rokoch sa ich pocet zdá byt stabilizovaný na kriticky nízkej úrovni. Pokles pocetnosti cistých párov bol prudší než u zmiešaných párov, ich podiel sa znížil z tretiny na štvrtinu z hniezdnych teritórií orla hrubozobého. Dnes je v Estónsku možné nájst 5 - 10 hniezdnych teritórií tohto druhu orla.

Redundant VoD Streaming Service in a Private Cloud: Availability Modeling and Sensitivity Analysis

OpenAIRE

Rosangela Maria De Melo; Maria Clara Bezerra; Jamilson Dantas; Rubens Matos; Ivanildo José De Melo Filho; Paulo Maciel

2014-01-01

For several years cloud computing has been generating considerable debate and interest within IT corporations. Since cloud computing environments provide storage and processing systems that are adaptable, efficient, and straightforward, thereby enabling rapid infrastructure modifications to be made according to constantly varying workloads, organizations of every size and type are migrating to web-based cloud supported solutions. Due to the advantages of the pay-per-use ...

Návod k trestnému činu jako forma účastenství

OpenAIRE

Vykoukalová, Kateřina

2009-01-01

The purpose of my thesis, called "Instigation to a crime as a form of complicity", is to analyze all aspects related to police provocation, which may be defined as an intentional, active incitement of other person to commit a criminal activity which they would not have otherwise committed. The aim of this work is to find answers especially to these questions: What does the term "police provocation" mean? What are legal consequences of using police provocation? Is it legal to use police provoc...

A Scalable QoS-Aware VoD Resource Sharing Scheme for Next Generation Networks

Science.gov (United States)

Huang, Chenn-Jung; Luo, Yun-Cheng; Chen, Chun-Hua; Hu, Kai-Wen

In network-aware concept, applications are aware of network conditions and are adaptable to the varying environment to achieve acceptable and predictable performance. In this work, a solution for video on demand service that integrates wireless and wired networks by using the network aware concepts is proposed to reduce the blocking probability and dropping probability of mobile requests. Fuzzy logic inference system is employed to select appropriate cache relay nodes to cache published video streams and distribute them to different peers through service oriented architecture (SOA). SIP-based control protocol and IMS standard are adopted to ensure the possibility of heterogeneous communication and provide a framework for delivering real-time multimedia services over an IP-based network to ensure interoperability, roaming, and end-to-end session management. The experimental results demonstrate that effectiveness and practicability of the proposed work.

Téma: David Miller o nacionalismu a globální spravedlnosti. Úvod

Czech Academy of Sciences Publication Activity Database

Velek, Josef

2007-01-01

Roč. 55, č. 2 (2007), s. 39-41 ISSN 0015-1831 Institutional research plan: CEZ:AV0Z90090514 Keywords : nationalism * cosmopolitanism * global justice * D. Miller Subject RIV: AA - Philosophy ; Religion

Synonymie v tzv. vodňanském lékařství

Czech Academy of Sciences Publication Activity Database

Černá, Alena M.

2013-01-01

Roč. 96, č. 2 (2013), s. 85-94 ISSN 0027-8203 R&D Projects: GA ČR GAP406/10/1140 Institutional support: RVO:68378092 Keywords : lexicon * Old Czech * synonyms * terminology Subject RIV: AI - Linguistics

A pilot study and novel angiographic classification for superior sagittal sinus stenting in patients with non-thrombotic intracranial venous occlusive disease.

Science.gov (United States)

Raper, Daniel M S; Buell, Thomas J; Ding, Dale; Pomeraniec, I Jonathan; Crowley, R Webster; Liu, Kenneth C

2018-01-01

Safety and efficacy of superior sagittal sinus (SSS) stenting for non-thrombotic intracranial venous occlusive disease (VOD) is unknown. The aim of this retrospective cohort study is to evaluate outcomes after SSS stenting. We evaluated an institutional database to identify patients who underwent SSS stenting. Radiographic and clinical outcomes were analyzed and a novel angiographic classification of the SSS was proposed. We identified 19 patients; 42% developed SSS stenosis after transverse sinus stenting. Pre-stent maximum mean venous pressure (MVP) in the SSS of 16.2 mm Hg decreased to 13.1 mm Hg after stenting (p=0.037). Preoperative trans-stenosis pressure gradient of 4.2 mm Hg decreased to 1.5 mm Hg after stenting (pSSS stenosis distal to the stent construct was noted. Improvement in headache, tinnitus, and visual obscurations was reported by 66.7%, 63.6%, and 50% of affected patients, respectively, at mean follow-up of 5.2 months. We divided the SSS into four anatomically equal segments, numbered S1-S4, from the torcula to frontal pole. SSS stenosis typically occurs in the S1 segment, and the anterior extent of SSS stents was deployed at the S1-S2 junction in all but one case. SSS stenting is reasonably safe, may improve clinical symptoms, and significantly reduces maximum MVP and trans-stenosis pressure gradients in patients with VOD with SSS stenosis. The S1 segment is most commonly stenotic, and minimum pressure gradients for symptomatic SSS stenosis may be lower than for transverse or sigmoid stenosis. Additional studies and follow-up are necessary to better elucidate appropriate clinical indications and long-term efficacy of SSS stenting. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Elevator cage

OpenAIRE

Matoušek, Jan

2009-01-01

Diplomová práce se zabývá pevnostním výpočtem rámu klece výtahu o nosnosti 400 kg (5 osob) a výpočtem maximální vzdálenosti mezi kotvami vodítek. Jmenovitá rychlost výtahu je 1 m.s -1. Součástí je analýza rámu pomocí metody konečných prvků. K této analýze byl použit program I – DEAS. This diploma thesis deals with design of a frame of a lift, whose roading capacity is 400 kg (5 people) and it olso deals with calculation of maximum distance between armatures of quides. Nominal speed is 1 m....

Tritium in underground-water studies; Emploi du tritium dans les etudes sur les eaux souterraines; Tritij v isledovaniyakh podzemnykh vod; Empleo del tritio en el estudio de las aguas subterraneas

Energy Technology Data Exchange (ETDEWEB)

Alekseev, F A; Gol' bek, G R; Sojfer, V N; Vasil' eva, N A; Majdebor, V N; Sokolovskij, Eh V; Shan' gin, N N

1962-01-15

: infiltracion del agua a traves de los sectores mas permeables del estrato, a velocidades comprendidas entre 10 y 30 m por dia, y avance del contorno basico de agua bombeada en una parte relativamente homogenea del estrato, a una velocidad de 2 m por dia. Este ultimo desplazamiento corresponde a las velocidades (1,9 a 2,2 m por dia) calculadas teoricamente para un estrato homogeneo. Es posible evaluar cuantitativamente el flujo en los desplazamientos de ambos tipos. Se ha ideado un metodo que emplea tritio para observar la comunicacion entre las aguas presentes en los distintos sectores intercalados en el estrato productivo de una vena petrolifera. Los autores proponen un metodo nuevo para controlar la explotacion de yacimientos petroliferos gracias al tritio natural contenido en las aguas superficiales inyectadas en el estrato, tanto en el interior como en el exterior del contorno. El lento desplazamiento del contorno de yacimientos petroliferos grandes, en los que se hayan realizado pocas perforaciones, puede ser estudiado durante periodos largos (unos 10 anos). De la cantidad de tritio desintegrado que contenga el agua subyacente a 1a. capa petrolifera de un pozo en explotacion pueden deducirse los tiempos y velocidades de desplazamiento del agua de contorno con una exactitud de {+-} 1 ano. Basta un numero reducido de analisis (no mas de 300 a 500 analisis por ano en un gran yacimiento) para seguir el desplazamiento del contorno. Se ha ideado un aparato sumamente sensible para medir el tritio en las aguas superficiales con contadores contrastados llenos de liquido. La mayor parte de las organizaciones industriales puede disponer de aparatos de este tipo. (author) [Russian] Izlagaetsya razvitie metoda vodnogo indikatora s ispol'zovaniem iskusstvennogo i prirodnogo tritiya pri izuchenii dvizheniya podzemnykh vod. Ustanovleno dva vozmozhnykh tipa dvizheniya zhidkosti po plastu, protiv vody po naibolee pronitsaemym uchastkam plasta so skorostyami 10/30 m/sutki i prodvizhenie

Biodegradace textilních barviv v odpadních vodách pomocí lakas

Czech Academy of Sciences Publication Activity Database

Herkommerová, Klára; Pichová, Iva

2017-01-01

Roč. 111, č. 12 (2017), s. 798-803 ISSN 0009-2770 R&D Projects: GA MŠk LO1302 Institutional support: RVO:61388963 Keywords : laccases * biotechnology * ”green” chemistry * synthetic dyes * wastewaters Subject RIV: CE - Biochemistry OBOR OECD: Biochemistry and molecular biology Impact factor: 0.387, year: 2016 http://www.chemicke-listy.cz/docs/full/2017_12_798-803.pdf

Předčištění odpadních vod elektrokoagulací

Czech Academy of Sciences Publication Activity Database

Krystyník, Pavel; Klusoň, Petr; Šolcová, Olga; Wimmerová, L.

2011-01-01

Roč. 2011, č. 2 (2011), s. 92-102 ISSN 1804-0195 R&D Projects: GA MPO(CZ) FR-TI1/065 Institutional research plan: CEZ:AV0Z40720504 Keywords : electrocoagulation * Fe removal * wastewater treatment Subject RIV: CI - Industrial Chemistry, Chemical Engineering

Methods and techniques of detecting petroleum-polluted water. Metody i tekhnika obnaruzheniya neftyanykh zagroyaznenii vod

Energy Technology Data Exchange (ETDEWEB)

Bogorodskii, V V; Kropotkin, M A; Sheveleva, T Yu

1975-01-01

The booklet presents physical principles and techniques of contact and remote sensing of oil pollution. Different methods and their practical possibilities are discussed. The possibility of application of remote CO/sub 2/-laser radar technique for the detection of oil pollution is considered. The booklet may be useful for specialists in oceanology, oceanic physics, meteorology, and in remote physical methods for environmental studies.

Návrhový systém pro zjištění a kvantifikaci požadavků na řídicí systém inteligentního domu

OpenAIRE

Kotík, Miloslav

2015-01-01

Bakalářská práce se věnuje analýze požadavků investora na řídicí systém inteligentního domu. Je navržen dotazník jako vodítko projektanta při komunikaci s investorem a tento postup je převeden do interaktivní podoby formuláře. Na základě dotazníku je poté navržen postup pro automatické vyhodnocení a převod zjištěných požadavků investora do seznamu doporučených komponent řídicího systému Tecomat Foxtrot a jeho periferií pro realizaci. První dvě kapitoly práce jsou teoretické a popisují intelig...

Fast polymer nanorectifiers for inductively coupled RFID tags

International Nuclear Information System (INIS)

Majewski, L.A.; Balocco, C.; King, R.; Whitelegg, S.; Song, A.M.

2008-01-01

In this article, an alternative approach to high switching speed organic rectifiers based on a semiconducting polymer, poly(dialkylquarterthiophene) (PQT-12) is demonstrated. It is shown that by using a linear array of polymer nanowires with intentionally broken symmetry, nanodevices displaying diode-like I/V characteristics can be obtained. The so-called self-switching devices (SSDs) are single-layered planar structures that can be easily fabricated in a single step of nanolithography. In addition, since SSD arrays possess substantially lower parasitic capacitance between contacts than conventional vertical organic diodes (VODs) and organic thin-film transistors (OTFTs), very high switching speeds may be achieved. As the result of this combination of favourable properties, we have demonstrated polymer nanorectifiers operating with frequencies well in excess of 1 MHz that have the potential to pave the way towards ultra low-cost radio frequency identification (RFID) tags

Kladná elektroda na bázi MnOx pro PEMFC

OpenAIRE

Šmídek, Miroslav

2011-01-01

Předkládaná bakalářská práce uvádí do problematiky vodíkových palivových článků a zaměřuje se na nízkoteplotní palivové články s polymerním elektrolytem (PEMFC). Základním zaměřením práce je studium vlastností katalyzátorů na bázi MnOx na reálném palivovém článku typu PEMFC. Výstupem jsou pak změřené charakteristiky takto vytvořeného palivového článku. Construed bachelor work features into problems hydrogen fuel articles and survey on low-temperature fuell elements with polymeric electroly...

CSS-Driven Java Swing Component

OpenAIRE

Hvězda, Matěj

2014-01-01

Tato práce je zaměřená na vytvoření komponenty Java Swing, která zobrazí obsah HTML dokumentu na základě kaskádových stylů (CSS). Důvod k vytvoření takové komponenty je umožnění vývojářům tvořit uživatelské rozhraní pomocí CSS v Javě bez nutnosti toho, aby znali rozhraní Java Swing.   K syntaktickému rozboru HTML a CSS je použit zobrazovací stroj CSSBox , který umožní získat veškeré potřebné informace ke správnému zobrazení dokumentu. Komponenta je implementována pomocí komponent Swingu...

Zdravotně technické instalace v penzionu

OpenAIRE

Ondrášek, Filip

2015-01-01

Bakalářská práce se zabývá odváděním splaškových a dešťových odpadních vod a zásobováním vodou v penzionu. Teoretická část práce řeší vedení instalací a dispoziční řešení hygienických zařízení. Technická část práce řeší vnitřní rozvody zdravotně technických instalací v penzionu. This bachelor’s work deals with drainage of domestic wastewater and rainwater and water supply in the boarding house. The theoretical part solves leading of installations and layout of sanitary facilities in boardi...

Transformace české ekonomiky kupónovou metodou

OpenAIRE

Junková, Monika

2008-01-01

Tato bakalářská práce by měla osvětlit proces transformace české a slovenské ekonomiky se zaměřením na kupónovou privatizaci, která v tomto procesu sehrála neodmyslitelnou roli. Úvod práce je věnován historickému ohlédnutí za československou ekonomikou v osmdesátých letech. Zachycuje společné počátky transformace v Československu, a to až do doby rozdělení republiky na dva samostatné státy. Poté je na obě země nahlíženo jako na samostatné celky, ve kterých se vyvíjely odlišné politické progra...

Investigation of Mineral Alteration in Andesite and Dacite from Three Different Volcano Hydrothermal Systems on Dominica, Lesser Antilles

Science.gov (United States)

Smith, C. I. V.; Frey, H. M.; Joseph, E. P.; Manon, M. R. F.

2017-12-01

The thermal discharges of Dominica are classified as steam-heated acidic-sulphate waters, produced by the mixing of shallow ground waters heated by sulphur bearing gases coming from magmatic sources. This study investigates the mineral alteration associated with three hydrothermal areas in Dominica that exhibit different temperature, pH, water composition and surface water abundance. Hydrothermal features (fumaroles, pools, springs) from Sulphur Springs ranged in temperature from 41 - 97 °C and pH from 1-3 in a predominantly gaseous environment, whereas the Valley of Desolation (69-98 °C and pH 1- 4) and the Cold Soufriere (18-32 °C and pH 1-4) have significant inputs of surface water. At each location, the host andesite-dacite rock was enveloped by a thin rind (up 2 cm) of precipitates, but the degree of alteration and rind thickness/composition varied with location. Cobbles from Sulphur Springs (SS) are grayish white in color with a thin outer rind (3-13 mm), and seemingly unaltered cores. Valley of Desolation (VoD) samples have a variety of patterns of alteration, with some clasts a uniform white-orange color, whereas others have variable thicknesses of an altered rind (1-20 mm), with relatively unaltered cores. Multiple hydrothermal minerals precipitated in the outer rinds display distinctive colors, suggestive of sulphides (dark gray), sulphates (orange and yellow), and iron oxides(?) (pink and purple). Cold Soufriere (CS) samples appear to be the most altered, often crumbling at touch. Others had rinds (2-10 mm) and pinkish gray cores that suggest more alteration compared to VoD and SS samples. Preliminary mineral identification of rind compositions was determined by XRD. Scans indicate the presence of silica polymorphs cristobalite and tridymite, as well as pyrite and sulphur. Elemental maps created using a SEM to identify any gradation caused by the elemental leaching and/or precipitation show that the boundaries between the weathering rind and the host

Monitorování úrovně hladin akumulovaných vod v Dole Jeroným

Czech Academy of Sciences Publication Activity Database

Lednická, Markéta; Kaláb, Zdeněk; Knejzlík, Jaromír

2012-01-01

Roč. 19, č. 2 (2012), s. 54-68 ISSN 1803-1447 R&D Projects: GA ČR GA105/09/0089 Institutional support: RVO:68145535 Keywords : mining backwater * water level fluctuation * dynamics of backwater Subject RIV: DC - Siesmology, Volcanology, Earth Structure http://www.caag.cz/egrse/2012-2/07_lednicka-r.pdf

Nerozpustné částice v mlžné vodě na Milešovce

Czech Academy of Sciences Publication Activity Database

Bartůňková, Kristýna; Fišák, Jaroslav; Stoyanova, V.

2014-01-01

Roč. 67, č. 3 (2014), s. 73-77 ISSN 0026-1173 R&D Projects: GA ČR GA205/09/1918 Institutional support: RVO:68378289 Keywords : insoluble particles * meteorological conditions * pollution in fog * source pollution Subject RIV: DG - Athmosphere Sciences, Meteorology

Remote sensing of petroleum contaminated water by IR lasers. Distantsionnoe obnaruzhenie neftyanykh zagryaznenii vod IK lazerom

Energy Technology Data Exchange (ETDEWEB)

Bogorodskii, V V; Kropotkin, M A

1975-01-01

The most important aspect of the protection of the environment is the prevention and elimination of the consequences of the pollution of seas, oceans, and inner water reservoirs by oil and oil products. The present booklet in a concise form presents the quantitative data characterizing the degree of sea and oceanic pollution, enumerates main sources of oil pollution, and considers the influence of the latter on ecology of the World Ocean. The available ways of water purification from surface oil products are discussed and techniques of remote sensing of oil pollution considered. The content of the work is the exposition of the results of investigations of optical properties of oil products and their films on the water in the ir spectral region and the conclusion on the possibility of the application of active remote laser radar technique for the detection of oil pollution.

Saxitoxin - neurotoxin produkovaný sinicemi v povrchových vodách České republiky

Czech Academy of Sciences Publication Activity Database

Jančula, Daniel; Babica, Pavel; Straková, Lucie; Sadílek, Jan; Maršálek, Blahoslav

2013-01-01

Roč. 63, č. 12 (2013), s. 406-409 ISSN 1211-0760 Grant - others:European Commission(XE) FP/2007-2013 no.2SGA2858 Institutional support: RVO:67985939 Keywords : cyanobacterial toxins * neurotoxin * hazard Subject RIV: EF - Botanics

Sledování obsahu tritia ve srážkových vodách

Czech Academy of Sciences Publication Activity Database

Světlík, Ivo; Budská, E.

2001-01-01

Roč. 9, 7/8 (2001), s. 251-254 ISSN 1210-7085 R&D Projects: GA AV ČR KSK4055109 Institutional research plan: CEZ:AV0Z1048901 Keywords : tritium * monitoring * atmospheric precipitation Subject RIV: DL - Nuclear Waste, Radioactive Pollution ; Quality

IPTV technology for the wireless Internet service provider (WISP

Directory of Open Access Journals (Sweden)

Mitchell Vásquez Bermúdez

2018-02-01

Full Text Available This article describes the implementation of the IPTV technology through an open source system for the wireless Internet service provider (WISP in the Cerecita site, located in the province of Guayas, Ecuador. The feasibility of implementing the IPTV technology is given through the use of the Emby Server application, in addition to the use of an operating system such as CentOS 7, which are open source and have the necessary requirements for the creation of this service. The analysis of data tra c generated on the WISP network, which will establish the advantages and disadvantages generated by the transmission of this technology, created to VOD multimedia content server that allows the video signal to be sent to users Finally, a feasibility study was carried out to analyze the advantages and disadvantages that exist in the implementation of this IPTV technology.

Sinusoidal obstruction syndrome.

Science.gov (United States)

Valla, Dominique-Charles; Cazals-Hatem, Dominique

2016-09-01

Sinusoidal obstruction syndrome (SOS) is characterized by damage to small hepatic vessels affecting particularly sinusoidal endothelium. Damaged sinusoids can be associated with a partial or complete occlusion of small hepatic veins, hence the previous denomination of hepatic veno-occlusive disease (VOD). Exposure to certain exogenous toxins appears to be specific to this condition and is frequently included in its definition. Typical histopathological features of SOS in a liver biopsy specimen are presented in the text. The purpose of this article is to provide an overview on the different entities corresponding to this general definition. Such entities include: (i) liver disease related to pyrrolizidine alcaloids; (ii) liver injury related to conditioning for hematopoietic stem cell transplantation; (iii) vascular liver disease occurring in patients treated with chemotherapy for liver metastasis of colorectal cancer; and (iv) other liver diseases related to toxic agents. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Company Communication Mix

OpenAIRE

Švecová, Michaela

2015-01-01

Predmetom bakalárskej práce “Komunikačný mix podniku” je analýza súčasného stavu komunikačného mixu vybraného podniku a návrh nového. Práca je rozdelená na teoretickú a praktickú časť. Teoretická časť pojednáva o význame marketingovej komunikácie, popisuje a porovnáva jednotlivé nástroje komunikačného mixu. Úvod praktickej časti popisuje vybranú spoločnosť. Hlavná časť analyzuje a hodnotí súčasné nástroje propagácie. Následuje realizovaný výskum zameraný na spokojnosť zákazníkov. Záverečná ča...

European Union RACE program contributions to digital audiovisual communications and services

Science.gov (United States)

de Albuquerque, Augusto; van Noorden, Leon; Badique', Eric

1995-02-01

The European Union RACE (R&D in advanced communications technologies in Europe) and the future ACTS (advanced communications technologies and services) programs have been contributing and continue to contribute to world-wide developments in audio-visual services. The paper focuses on research progress in: (1) Image data compression. Several methods of image analysis leading to the use of encoders based on improved hybrid DCT-DPCM (MPEG or not), object oriented, hybrid region/waveform or knowledge-based coding methods are discussed. (2) Program production in the aspects of 3D imaging, data acquisition, virtual scene construction, pre-processing and sequence generation. (3) Interoperability and multimedia access systems. The diversity of material available and the introduction of interactive or near- interactive audio-visual services led to the development of prestandards for video-on-demand (VoD) and interworking of multimedia services storage systems and customer premises equipment.

Praktické využití vizuální komunikace firem a grafický manuál

OpenAIRE

Jehlička, Marek

2006-01-01

Bakalářská práce je zaměřená na problematiku vizuální komunikace firem, s důrazem firemní grafický styl a grafický manuál. Úvod metodologické části je zaměřen na smysl, využití a možnosti vizuální komunikace. Dále je rozebírána otázka standardů firemního stylu a základních stavebních kamenů vizuální komunikace firemní image, firemní kultury, firemní identity a firemního stylu. Praktická část obsahuje vypracovaný grafický manuál pro fiktivní firmu, jehož součástí je logomanuál s příklady přípu...

Sledování změn hodnot vybraných ukazatelů jakosti pitné vody během její dopravy a skladování

OpenAIRE

Vaňková, Jitka

2008-01-01

Teoretická část práce poskytuje informace o pitné vodě a požadavcích na její kvalitu, změnách jakosti vody při distribuci a akumulaci vody způsobené desinfekcí vody, dobíháním chemických procesů, korozí materiálů potrubí, tvorbou inkrustací a biofilmů, nitrifikací amoniakálního dusíku, sedimenty v potrubí, vyluhováním škodlivých látek do vody a možnostech omezení těchto změn. Pozornost byla věnována ukazatelům jakosti vody, jejichž přítomnost může indikovat změny ve vodovodní síti. V experime...

Flexibility in Management of Modernization in Construction - Electrical Works/ Elastyczność W Zarządzaniu Modernizacją Obiektów Budowlanych Na Przykładzie Robót Elektrycznych

Directory of Open Access Journals (Sweden)

Nowotarski Piotr

2015-06-01

Full Text Available Artykuł prezentuje możliwość zastosowania elastyczności w modernizacjach istniejących obiektów budowlanych na przykładzie instalacji oświetleniowej. Elastyczność jest rozumiana w tym przypadku jako umiejętne dostosowanie się do zmian w dynamicznie zmieniającym się środowisku. Istotą podejścia elastycznego jest podejmowanie odpowiednich decyzji w odpowiednim czasie opartych na monitoringu środowiska i procesu w toku. Prezentowane studium przypadku modernizacji instalacji elektrycznej w budownictwie wielorodzinnym w częściach wspólnych obiektu (korytarze, klatki schodowe, hala garażowa opiera się na wymianie i modernizacji tylko tych punktów, które w danym momencie ulegają awarii. Prosta analiza oby typów modernizacji opiera się na porównaniu kosztów, natomiast trzeba zaznaczyć, że możliwe są także inne kryteria (środowiskowe, konfliktu społecznego, itp., które będą przedmiotem kolejnych publikacji. Zastąpienie tradycyjnych żarówek rozwiązaniami opartymi na technologii LED z zastosowaniem czujników ruchu może prowadzić do znacznych oszczędności, ale może też oznaczać obniżenie komfortu dla użytkowników (np. dla osób starszych, którym jeden cykl działania oświetlenia nie jest wystarczający do pokonania całej drogi na korytarzu. Osiągnięcie kompromisu w tego typu konfliktach interesów może być rozwiązane za pomocą podejścia elastycznego i zwinnego.

Expectations and decisions in the Volunteer’s Dilemma: Effects of social distance and social projection

Directory of Open Access Journals (Sweden)

Joachim Israel Krueger

2016-12-01

Full Text Available In a Volunteer’s Dilemma (VoD one individual needs to bear a cost so that a public good can be provided. Expectations regarding what others will do play a critical role because they would ideally be negatively correlated with own decisions; yet, a social-projection heuristic generates positive correlations. In a series of 2-person-dilemma studies with over 1,000 participants, we find that expectations are indeed correlated with own choice, and that people tend to volunteer more than game-theoretic benchmarks and their own expectations would allow. We also find strong evidence for a social-distance heuristic, according to which a person’s own probability to volunteer and the expectation that others will volunteer decrease as others become socially more remote. Experimentally induced expectations make opposite behavior more likely, but respondents underweight these expectations. As a result, there is a small but systematic effect of overvolunteering among psychologically close individuals.

A new IPQAM modulator with high integrated degree for digital TV

Science.gov (United States)

He, Yejun; Liu, Deming; Zhu, Guangxi; Jiang, Tao; Sun, Gongxian

2008-12-01

As video on demand (VOD) services are deployed, cable operators will experience a fundamental shift in their business, moving from broadcast to unicast content delivery. Another significant change is the introduction of Gigabit Ethernet into their network, which is providing an unprecedented opportunity to turn the cable operator's infrastructure into a sustainable competitive advantage. However, Gigabit Ethernet is more than just transport; it's the foundation of the Next-Generation Digital Video Network. IPQAM modulator, which is a main equipment, aren't made in China so far. It is the first time that we did design IPQAM modulator and will apply it to interactive TV based on DWDM (dense wavelength-division multiplexing). This paper introduces the principle of IPQAM modulator and transmission approach. The differences between IPQAM and conventional QAM are analysed. Some key techniques such as scrambling, statistical multiplexing, Data over Cable Service Interface Specification (DOCSIS) 3.0, software defined radio as well as DVB simulcrypt are also studied.

An Evaluation of Media-Oriented Rate Selection Algorithm for Multimedia Transmission in MANETs

Directory of Open Access Journals (Sweden)

Guionnet Thomas

2005-01-01

Full Text Available We focus on the optimization of real-time multimedia transmission over 802.11-based ad hoc networks. In particular, we propose a simple and efficient cross-layer mechanism that considers both the channel conditions and characteristics of the media for dynamically selecting the transmission mode. This mechanism called media-oriented rate selection algorithm (MORSA targets loss-tolerant applications such as VoD that do not require full reliable transmission. We provide an evaluation of this mechanism for MANETs using simulations with NS and analyze the video quality obtained with a fine-grain scalable video encoder based on a motion-compensated spatiotemporal wavelet transform. Our results show that MORSA achieves up to 4 Mbps increase in throughput and that the routing overhead decreases significantly. Transmission of a sample video flow over an 802.11a wireless channel has been evaluated with MORSA. Important improvement is observed in throughput, latency, and jitter while keeping a good level of video quality.

Posouzení účinnosti filtračního materiálu DMI-65 na odstraňování kovů z vody

OpenAIRE

Konečný, Jiří

2016-01-01

Diplomová práce se v první kapitole zabývá různými vodárenskými procesy, kterými je možno odstranit sloučeniny kovů a polokovů z vody. Podstatná část je věnována filtračním materiálům, mezi něž se řadí v celku nový filtrační materiál DMI-65. Filtračnímu materiálu DMI-65 je věnována obsáhlá kapitola, která podrobně popisuje vlastnosti, charakter a použití v praxi. Další kapitola práce popisuje průběh poloprovozní zkoušky materiálu DMI-65 na úpravně vody v Ivančicích. Na závěr je popsána labora...

Návrh pracoviště obrábění hřídelí elektromotorů

OpenAIRE

Knobloch, Martin

2014-01-01

Cílem práce na téma „Návrh pracoviště obrábění hřídelí elektromotorů“ je zavedení nové technologie do výroby hřídelí v odštěpném závodě Siemens s.r.o., o.z. Elektromotory Mohelnice. Na začátku je popsána teorie přípravy výroby a metody vedoucí ke stanovení nejvhodnější metody výroby a její zavedení do praxe. V další kapitole se práce zaměřuje na popis stávajícího procesu a vyhodnocení největších úskalí procesu. Následuje variantní návrh nového pracoviště včetně posouzení z hlediska technologi...

Expectations and Decisions in the Volunteer’s Dilemma: Effects of Social Distance and Social Projection

Science.gov (United States)

Krueger, Joachim I.; Ullrich, Johannes; Chen, Leonard J.

2016-01-01

In a Volunteer’s Dilemma (VoD) one individual needs to bear a cost so that a public good can be provided. Expectations regarding what others will do play a critical role because they would ideally be negatively correlated with own decisions; yet, a social-projection heuristic generates positive correlations. In a series of 2-person-dilemma studies with over 1,000 participants, we find that expectations are indeed correlated with own choice, and that people tend to volunteer more than game-theoretic benchmarks and their own expectations would allow. We also find strong evidence for a social-distance heuristic, according to which a person’s own probability to volunteer and the expectation that others will volunteer decrease as others become socially more remote. Experimentally induced expectations make opposite behavior more likely, but respondents underweight these expectations. As a result, there is a small but systematic effect of over-volunteering among psychologically close individuals. PMID:28018257

Oospila bulava, a new emerald geometrid moth from South America (Lepidoptera, Geometridae, Geometrinae).

Science.gov (United States)

Lindt, Aare; Viidalepp, Jaan

2015-12-15

Warren (1897) described the genus Oospila for Phorodesma trilunaria Guenée, 1857 from Brazil. Prout (1912; 1932-1933) revised the genus, listing 48 species in the first publication and 58 species in the latter one, in Oospila. Cook and Scoble (1995) grouped eight related genera under Oospila, including 73 species and dividing these into 13 species groups. Pitkin (1996) relied on this revision while publishing a monographic review of the Neotropical geometrine genera. Parsons et al. (1999) attributed the same species that in Cook and Scoble (1995) to the genus. Two species are described later (Viidalepp, 2002; Lévèque & Viidalepp, 2015). While revising collections from the Neotropical region during the last decade, the authors of the present article have found several undescribed taxa: cryptic species are frequently overlooked in large-scale works (Vodă et al., 2014). The result of one case study is published in this article. The primary and subsequent descriptions of relevant taxa are consulted.

Drying effects on the antioxidant properties of tomatoes and ginger.

Science.gov (United States)

Gümüşay, Özlem Aktürk; Borazan, Alev Akpınar; Ercal, Nuran; Demirkol, Omca

2015-04-15

In this study, the effects of four different drying processes, sun drying (SD), oven drying (OD), vacuum oven drying (VOD) and freeze drying (FD) for tomatoes (Solanum lycopersicum) and ginger (Zingiber officinale) in terms of thiolic and phenolic contents have been studied. Thiol content, total phenolic content (TPC), ascorbic acid (AA) content, and cupric ion reducing antioxidant capacity (CUPRAC) were determined in fresh and dried samples. Glutathione (GSH) and cysteine (Cys) were determined as the thiol contents of tomatoes and ginger. Significant losses were observed in the contents of TPC, AA, GSH and Cys and CUPRAC values in all samples that were dried using the thermal method. There was a statistically significant difference in the losses of the TPC, AA, and thiol contents between the use of thermal drying and freeze drying (except Cys in tomatoes) methods. Freeze dried tomato and ginger samples have been found to have better antioxidant properties. Copyright © 2014 Elsevier Ltd. All rights reserved.

Detekce útoku DNS Amplification z pasivní analýzy DNS provozu

OpenAIRE

Míšaný, Daniel

2014-01-01

Táto práce je zaměřená na analýzu a detekci útoku DNS amplification, který patří mezi útoky typu DoS. Úvod práce je zaměřený na základní teorii zahrnující počítačové sítě, službu DNS a útoky typu DoS. Větší část práce se zabývá analýzou útoku DNS amplification, návrhem a implementací nástroje pro detekci v jazyce C++. Závěr je věnovaný analýze výsledků detekčního nástroje. This thesis is focused on the analysis and detection of DNS Amplification attack which is type of the DoS attack. Intr...

Sledování účinnosti vybraných filtračních materiálů na odstraňování železa a manganu z vody

OpenAIRE

Ševčíková, Ilona

2016-01-01

Diplomová práce se zabývá problematikou odstraňování železa a manganu z vody. První část práce pojednává o formách výskytu železa a manganu ve vodách, vlivu železa a manganu na zdraví člověka, možnostech odstraňování železa a manganu z vody. Podrobněji je popsána kontaktní filtrace a materiály, které se ke kontaktnímu odželezování a odmanganování využívají. Ve druhé části práce je popsáno využívání filtračních materiálů Birm, Greensand a Semidol v praxi a popis experimentálního odstranění žel...

Mezinárodní účetní standardy pro veřejný sektor versus česká účetní legislativa

OpenAIRE

Helus, Petr

2008-01-01

Práce se dívá na problematiku účetnictví a účetního výkaznictví subjektů veřejného sektoru optikou české účetní legislativy a Mezinárodních účetních standardů pro veřejný sektor (IPSAS). Úvod umožní čtenáři vytvořit si letmou představu o tom, jakým způsobem jsou IPSAS koncipovány a o jaké principy se opírají. První kapitola pojedává o institucích, které jsou s existencí IPSAS neodmyslitelně spojeny. Druhá kapitola popisuje institucionální uspořádání veřejného sektoru v ČR a s ním související ...

Diagnostika diafragmového výboje v kapalinách

OpenAIRE

Hlavatá, Lucie

2009-01-01

Hlavním cílem této práce je diagnostika diafragmového výboje v kapalinách. Ačkoli byla v posledních letech objevena celá řada aplikací elektrického výboje v kapalinách, vlastní mechanismus vzniku tohoto výboje není dosud znám. Z těchto důvodů se tato práce zaměřila na studium dějů předcházejících samotnému zapálení výboje, zápalného napětí, samotného výboje jak v oblastech náhodného průrazu tak i pravidelnému výboji. Použitím roztoků dvou anorganických solí o různých vodivostech práce zkoumal...

Návrh zásobníku na sypký vápenný hydrát

OpenAIRE

Perna, Marek

2009-01-01

Tato diplomová práce řeší návrh hlubokého zásobníku na sypký vápenný hydrát pro technologická zařízení čistíren odpadních vod. Je zde proveden rozbor volby typu a konstrukce zásobníku, návrh rozměrů a pevnostní výpočet zásobníku. Je zde popsána možnost vzniku klenby při vyprazdňování a její potlačení pomocí aktivních a pasivních prvků napomáhající toku. Popis aktivních a pasivních stavů napjatosti materiálu v zásobníku. This diploma thesis is solving systems design of silo for a powdery li...

Limitation of the influx of formation water into oil wells. Ogranichenie pritoka plastovykh vod v neftyanye skvazhiny

Energy Technology Data Exchange (ETDEWEB)

Bulgakov, R.T.; Gazizov, A.Sh.; Gabdullin, R.G.; Yusupov, I.G.

1976-01-01

The problems of limiting the influx of water into oil wells are examined. On the basis of studies, systemization, and generalization of the reasons for the premature flooding of wells, the improvement of strata by polymer-cement solutions with consolidating liquid phases is considered. A detailed description is given of the technology and results of cementing well using solutions based on plugging cement and water-soluble phenol-formaldehyde resins of the TSD-9 type. Results are reported on the study of the properties of selective water-insulating substances based on acrylamide monomers and hydrolyzed polyacrylonitriles. Industrial testing of these materials is generalized. An economic evaluation is made of the efficiency of measures undertaken to prevent water influx into oil wells.

Praktická aplikace fotochemických a fotokatalytických procesů při dekontaminaci vod

Czech Academy of Sciences Publication Activity Database

Mašín, P.; Žebrák, R.; Klusoň, Petr; Šolcová, Olga

2015-01-01

Roč. 2015, č. 2 (2015), s. 111-117 ISSN 1804-0195. [ročník česko-slovenského symposia Odpadové fórum 2015 /10./. Hustopeče, 18.03.2015-20.03.2015] R&D Projects: GA TA ČR TA01020804; GA TA ČR TA04020130 Institutional support: RVO:67985858 Keywords : photochemical oxidation H2O2 /UVC * photocatalytic oxidation TiO2/UV * pilot scale unit Subject RIV: DJ - Water Pollution ; Quality http://hdl.handle.net/11104/0250529

Chemiluminiscenční průtokové stanovení dusičnanů ve vodě

Czech Academy of Sciences Publication Activity Database

Mikuška, Pavel; Večeřa, Zbyněk

2002-01-01

Roč. 96, č. 9 (2002), s. 748-750 ISSN 0009-2770 R&D Projects: GA AV ČR IAA4031105; GA ČR GA203/98/0943 Grant - others:Copernicus(XE) SUB-AERO-EVK2-1999-0052 Institutional research plan: CEZ:AV0Z4031919 Keywords : nitrate * FIA * chemiluminescence Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 0.336, year: 2002

Analýza turistických služeb na vybrané vodácké trase

OpenAIRE

Dýšková, Pavlína

2011-01-01

This thesis deals with tourist services provided on the boating route Týnec nad Sázavou - Pikovice and with their analysis. It is divided into four chapters. The first of these defines the key concepts concerning boating and selected tourist services. The second part focuses more closely on the river Sázava and on the selected route from Týnec nad Sázavou to Pikovice, which is a part of the river. The third chapter describes in detail chosen establishments providing tourist services on the se...

The global SMOS Level 3 daily soil moisture and brightness temperature maps

Directory of Open Access Journals (Sweden)

A. Al Bitar

2017-06-01

Full Text Available The objective of this paper is to present the multi-orbit (MO surface soil moisture (SM and angle-binned brightness temperature (TB products for the SMOS (Soil Moisture and Ocean Salinity mission based on a new multi-orbit algorithm. The Level 3 algorithm at CATDS (Centre Aval de Traitement des Données SMOS makes use of MO retrieval to enhance the robustness and quality of SM retrievals. The motivation of the approach is to make use of the longer temporal autocorrelation length of the vegetation optical depth (VOD compared to the corresponding SM autocorrelation in order to enhance the retrievals when an acquisition occurs at the border of the swath. The retrieval algorithm is implemented in a unique operational processor delivering multiple parameters (e.g. SM and VOD using multi-angular dual-polarisation TB from MO. A subsidiary angle-binned TB product is provided. In this study the Level 3 TB V310 product is showcased and compared to SMAP (Soil Moisture Active Passive TB. The Level 3 SM V300 product is compared to the single-orbit (SO retrievals from the Level 2 SM processor from ESA with aligned configuration. The advantages and drawbacks of the Level 3 SM product (L3SM are discussed. The comparison is done on a global scale between the two datasets and on the local scale with respect to in situ data from AMMA-CATCH and USDA ARS Watershed networks. The results obtained from the global analysis show that the MO implementation enhances the number of retrievals: up to 9 % over certain areas. The comparison with the in situ data shows that the increase in the number of retrievals does not come with a decrease in quality, but rather at the expense of an increased time lag in product availability from 6 h to 3.5 days, which can be a limiting factor for applications like flood forecast but reasonable for drought monitoring and climate change studies. The SMOS L3 soil moisture and L3 brightness temperature products are delivered using an

Původ kreativní ekonomiky včetně demonstraci vlivu na hospodářský rozvoj

Directory of Open Access Journals (Sweden)

Jitka Kloudová

2014-03-01

Full Text Available Purpose of the article: This study presents the comprehensive theoretical framework of a new growth theory called “creative economy”. Recently, more and more of awareness is given to the creativity. Actually, the European Union nominates the year of 2009 as a year of creativity and innovation. On the other hand there is still not any unification concept of the creativity. Methodology/methods: That is why there is a need to formulate new paradigm in a form of creative economy, so that we would be able to understand the role of creativity in economic and social development. To construct the basic pillars of creative economy, this study used selected milestones from previous growth theories and as well is inspired by the period of modern economic growth that began with the emergence of an Industrial Revolution. Scientific aim: This theory defines a new emerging paradigm based on the presenting points. In the final section, theoretical conclusions of this work are documented by outputs obtained thanks to using a New creative index. This index was designed in such a way to come from the definition of creative economy while eliminate discrepancies of previous models. Findings: The current outputs have shown that regions with a significant creative potential (expressed by the New creative index are achieving higher rate of economic level, more favorable demographic structure, better results in employment and in others macroeconomic indicators. Conclusions: The understanding of the concept of creative economy is the first step for setting strategy that will lead to ensuring competitiveness in today‘s global world.

Models and mechanisms of IPTV VоD traffic balancing

OpenAIRE

Klymash, Mykhailo; Hayali, Yasser; Lavriv, Orest

2012-01-01

Models for traffic balancing that enable to evaluate the current IPTV traffic balancing mechanisms are suggested in this paper. Also, an analysis of each of these mechanisms is performed using the IPTV traffic model. Запропоновано моделі балансування трафіку IPTV VoD для оцінки існуючих механізмів балансування. Проведено аналіз кожного з цих механізмів за допомогою моделі IPTV трафіку....

Analysis and application of intelligence network based on FTTH

Science.gov (United States)

Feng, Xiancheng; Yun, Xiang

2008-12-01

With the continued rapid growth of Internet, new network service emerges in endless stream, especially the increase of network game, meeting TV, video on demand, etc. The bandwidth requirement increase continuously. Network technique, optical device technical development is swift and violent. FTTH supports all present and future service with enormous bandwidth, including traditional telecommunication service, traditional data service and traditional TV service, and the future digital TV and VOD. With huge bandwidth of FTTH, it wins the final solution of broadband network, becomes the final goal of development of optical access network. Firstly, it introduces the main service which FTTH supports, main analysis key technology such as FTTH system composition way, topological structure, multiplexing, optical cable and device. It focus two kinds of realization methods - PON, P2P technology. Then it proposed that the solution of FTTH can support comprehensive access (service such as broadband data, voice, video and narrowband private line). Finally, it shows the engineering application for FTTH in the district and building. It brings enormous economic benefits and social benefit.

The experimental optical burst switching system

Science.gov (United States)

Li, Xinwan; Chen, Jian-Ping; Wu, Guiling; Wang, Hui; Lu, Jialin; Ye, Ailun

2005-02-01

The first optical burst switching (OBS) system has been demonstrated in China, which includes three edge routers and one core-node. A kind of fast wavelength selective optical switching was used in the system. The core OBS node consists of a kind of wavelength selective optical switch we developed. It consists of two SOA switches and one wavelength selective thin film filter with centre wavelength at one wavelength. There are one input optical fiber and two output fibers, each fiber carries two wavelengths. The Dell PE2650 servers act as the edge OBS routers. The wavelength of each data channel is located in C-band and the bit rate is at 1.25Gbps. The control channel uses bit rate of 100Mbps at wavelength of 1310 nm. A novel effective scheme for Just-In-Time (JIT) protocol was proposed and implemented. OBS services, such as Video on Demand (VOD) and file transfer protocol (FTP), have been demonstrated. Assembling and scheduling methods that are capable to guarantee the QoS (quality of service) of the transported service are studied.

Total body irradiation in the bone marrow transplantation in leukemia:an experience

International Nuclear Information System (INIS)

Zapatero, A.; Martin de Vidales, C.; Pinar, B.; Marin, A.; Cerezo, L.; Dominguez, P.; Perez, A.

1996-01-01

The purpose of this report was to evaluate long-term survival and morbidity of fractioned total body irradiation (TBI) prior to allogeneicbone marrow transplantation (BMT) for leukemia. From June 1985 to May 1992, 94 patients with acute leukemia and chronic myelogenous leukemia (CML), were treated with high dose cyclophosphamide(CY) and fractionated TBI to a total dose of 12 Gy in six fractions prior to allogeneic BMT. The Kaplan-Meier 5-year overall survival and disease-free survival were 53% +-6 and 48%+- respectively for patients with standard risk disease (first remission of acute leukemia and first chronic phase of CML), and 24%+-7 and 21%+-6 for patients with more advanced disease (p=3D0.01). The incidence of interstitial pneumonitis (IP), venoocclusive disease of the liver (VOD) and grade=3D>II acute graft-versus-host disease (GVHD) were respectively 15%, 29% and 51%. Fractionated TBI combined with high dose CY before allogeneic BMT for leukemia is an effective treatment in prolonging relapse-free survival witha low incidence of lung toxicity. (Author) 13 refs

Total body irradiation in the bone marrow transplantation in leukemia: an experience; Irradiacion corporal total fraccionada en el transplante de medula osea ologenica en leucemias: experiencia de un centro

Energy Technology Data Exchange (ETDEWEB)

Zapatero, A; Martin de Vidales, C; Pinar, B; Marin, A; Cerezo, L; Dominguez, P; Perez, A [Servicio de Oncologia Radidoterapica Hospital Universitario de la Princesa, Madrid (Spain)

1996-06-01

The purpose of this report was to evaluate long-term survival and morbidity of fractioned total body irradiation (TBI) prior to allogeneic bone marrow transplantation (BMT) for leukemia. From June 1985 to May 1992, 94 patients with acute leukemia and chronic myelogenous leukemia (CML), were treated with high dose cyclophosphamide (CY) and fractionated TBI to a total dose of 12 Gy in six fractions prior to allogeneic BMT. The Kaplan-Meier 5-year overall survival and disease-free survival were 53% +-6 and 48%+- respectively for patients with standard risk disease (first remission of acute leukemia and first chronic phase of CML), and 24%+-7 and 21%+-6 for patients with more advanced disease (p=0.01). The incidence of interstitial pneumonitis (IP), venoocclusive disease of the liver (VOD) and grade=>II acute graft-versus-host disease (GVHD) were respectively 15%, 29% and 51%. Fractionated TBI combined with high dose CY before allogeneic BMT for leukemia is an effective treatment in prolonging relapse-free survival with a low incidence of lung toxicity. (Author) 13 refs.

Separátory, sedimentační nádrže včetně funkce retenční nádrže Jeneweinova

OpenAIRE

Turic, Jakub

2016-01-01

Tato bakalářská práce se zabývá problematikou separátorů a sedimentačních nádrží, včetně funkce retenční nádrže Jeneweinova v Brně. Popisuje základní fyzikální a hydrodynamické vlastnosti vod a rozděluje její znečištění. Dále se zabývá popisem jednotlivých separačních a sedimentačních nádrží, jejich účel a využití. Zabývá se vznikem povodní a využití retenčních nádrží jako protipovodňové ochrany. Součástí práce je popis retenční nádrže Jeneweinova, její návrh, účel a funkce. The subject of...

Zdravotně technické instalace provozní a výrobní budovy

OpenAIRE

Nesvadbová, Petra

2012-01-01

Administrativní budova se zázemím šaten a umýváren pro přidruženou průmyslovou výrobu v hale. Využití dešťových vod pro splachování. Řešeno oddílnou kanalizací. Dešťová voda je přivedena do retenční nádrže, odkud je odebírána pro splachování. Přebytečná dešťová voda se vsakuje pomocí bloků seskládaných do drenážního systému v podzemním prostoru. Šetření vody pomocí úsporných armatur a zařízení. Navrženy úsporné sprchové hlavice, baterie, WC nádržky s úsporným provozem a pisoáry. Administra...

Využití GC/MS při analýze léčiv

OpenAIRE

Sýkora, Richard

2011-01-01

Tato diplomová práce vychází z aktuální problematiky přítomnosti léčiv v různých složkách životního prostředí. Nejvíce zatížené prostředí z pohledu kontaminace rezidui léčiv je prostředí vodné, do kterého se tyto látky dostávají především z čistíren odpadních vod, ve kterých dochází jen k jejich částečné eliminaci během čistících procesů. Předkládaná práce je zaměřena na stanovení vybraných léčiv ze skupiny nesteroidních protizánětlivých látek (kyselina salicylová, ibuprofen, kofein, naproxen...

Separace pevných částic z heterogenní suspenze

OpenAIRE

Prax, Ondřej

2009-01-01

Bakalářská práce obsahuje literární rešerši zabývající se separací pevných částic z heterogenní suspenze. První část je věnována pojednání o separačních metodách. Na ni navazuje kapitola o separačních zařízeních, které se používají na čistírnách odpadních vod. Součásti práce je podrobnější popis separátoru, který slouží k separaci písku z odpadní vody. Popisované zařízení sloužící k oddělování pevných složek ze suspenze využívá kombinace metod sedimentace a odstřeďování. K vizualizaci separát...

Climatic drivers of vegetation based on wavelet analysis

Science.gov (United States)

Claessen, Jeroen; Martens, Brecht; Verhoest, Niko E. C.; Molini, Annalisa; Miralles, Diego

2017-04-01

Vegetation dynamics are driven by climate, and at the same time they play a key role in forcing the different bio-geochemical cycles. As climate change leads to an increase in frequency and intensity of hydro-meteorological extremes, vegetation is expected to respond to these changes, and subsequently feed back on their occurrence. This response can be analysed using time series of different vegetation diagnostics observed from space, in the optical (e.g. Normalised Difference Vegetation Index (NDVI), Solar Induced Fluorescence (SIF)) and microwave (Vegetation Optical Depth (VOD)) domains. In this contribution, we compare the climatic drivers of different vegetation diagnostics, based on a monthly global data-cube of 24 years at a 0.25° resolution. To do so, we calculate the wavelet coherence between each vegetation-related observation and observations of air temperature, precipitation and incoming radiation. The use of wavelet coherence allows unveiling the scale-by-scale response and sensitivity of the diverse vegetation indices to their climatic drivers. Our preliminary results show that the wavelet-based statistics prove to be a suitable tool for extracting information from different vegetation indices. Going beyond traditional methods based on linear correlations, the application of wavelet coherence provides information about: (a) the specific periods at which the correspondence between climate and vegetation dynamics is larger, (b) the frequencies at which this correspondence occurs (e.g. monthly or seasonal scales), and (c) the time lag in the response of vegetation to their climate drivers, and vice versa. As expected, areas of high rainfall volumes are characterised by a strong control of radiation and temperature over vegetation. Furthermore, precipitation is the most important driver of vegetation variability over short terms in most regions of the world - which can be explained by the rapid response of leaf development towards available water content

Zvířecí kosterní pozůstatky z popraviště ve Vodňanech

Czech Academy of Sciences Publication Activity Database

Kyselý, René

2006-01-01

Roč. 58, č. 4 (2006), s. 813-814 ISSN 0323-1267 Institutional research plan: CEZ:AV0Z80020508 Keywords : scaffold * Bos taurus * burned bones * archaeozoology Subject RIV: AC - Archeology, Anthropology, Ethnology

Geographic Information Systems in Developing Countries – What are the Ethical Issues we need to be aware of ? / Geografické Informační Systémy A Jejich Využití V Rozvojových Zemích - Jakým Etickým Otázkám Musíme Čelit?

Directory of Open Access Journals (Sweden)

Pánek Jiří

2013-06-01

Full Text Available Využití geografických informačních systémů (GIS v rozvojových zemích se musí potýkat s historickou skepsí, kterou mapy, jako nástroj moci, mají mezi původními obyvateli. Participativní přístupy v mapování a GIS se snaží přistupovat k místním prostorovým znalostem s větší mírou společenské a etické zodpovědnosti. Článek se soustředí na popis vybraných důvodů, které vedly ke skeptickému postoji vůči GIS, a na identifikaci základních etických otázek sběru a interpretace prostorových informací v rozvojových zemích na příkladu mapování vodních zdrojů ve vesnici Koffiekraal v Jihoafrické republice.

Successful treatment with defibrotide for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation.

Science.gov (United States)

Yakushijin, Kimikazu; Matsui, Toshimitsu; Okamura, Atsuo; Yamamoto, Katsuya; Ito, Mitsuhiro; Chihara, Kazuo

2005-01-01

Sinusoidal obstruction syndrome (SOS) (formerly known as hepatic veno-occlusive disease (VOD)) is a life-threatening complication subsequent to hematopoietic stem cell transplantation. However, no completely satisfactory strategies for the treatment of SOS have been established yet. Defibrotide is a single-stranded polydeoxyribonucleotide with anti-thrombotic, anti-ischemic, anti-inflammatory and thrombolytic properties, but without systemic anticoagulant effects, and some encouraging results have been reported in western countries. We treated four patients with defibrotide for SOS, since there seemed to be no possibility to cure the patients with conventionally available treatments in Japan. All patients showed evidence of multiple organ failure at the start of the treatment. Defibrotide was administered intravenously in normal saline in four divided doses for 14 to 27 days. Three patients (75%) responded to the therapy, while one died of SOS and cytomegalovirus infection despite intensive therapy. None of the patients suffered from significant adverse effects such as severe hemorrhage. This is the first report dealing with the treatment with defibrotide of Japanese patients with SOS. Because defibrotide is considered to be promising for the treatment of SOS, it is important to start a phase II study as soon as possible.

Optimalizace manipulační techniky v podniku Nestlé Česko s.r.o., závod ZORA Olomouc

OpenAIRE

Kovář, Jiří

2015-01-01

This thesis discusses the optimal way of material-handling equipment replacement at Nestlé Česko s.r.o., plant ZORA Olomouc. The theoretical part describes the issue of warehousing in general and focuses on the material-handling equipment and vehicles. The following analytical part focuses specifically on the company Nestlé Česko s.r.o., particularly the plant ZORA Olomouc with the foremost aim of analysing and optimising the current material-handling equipment.

Klíčové faktory určující chemickou diverzitu aluviálních vod

Czech Academy of Sciences Publication Activity Database

Pithart, David; Pechar, Libor

3,21, 2-3 (2004), s. 269-273 ISSN 1212-0731. [Agroregion 2004. České Budějovice, 06.09.2004-07.09.2004] R&D Projects: GA MŽP SM/640/18/03; GA ČR GA206/01/1113 Institutional research plan: CEZ:AV0Z6087904 Keywords : riparian zone * alluvial pools * water chemistry Subject RIV: DA - Hydrology ; Limnology

Veno-occlusive liver disease after infradiaphragmatic total lymphoid irradiation. A rare complication; Die Venenverschlusskrankheit der Leber nach infradiaphragmaler total lymphatischer Bestrahlung. Eine seltene Nebenwirkung

Energy Technology Data Exchange (ETDEWEB)

Bischof, M.; Zierhut, D.; Gutwein, S.; Wannenmacher, M. [Heidelberg Univ. (DE.) Abt. fuer Klinische Radiologie - Schwerpunkt Strahlentherapie; Hansmann, J. [Heidelberg Univ. (DE.) Abt. fuer Radiologische Diagnostik; Stremmel, W.; Mueller, M. [Heidelberg Univ. (DE). Abt. Innere Medizin 4 (Schwerpunkt Gastroenterologie)

2001-06-01

Background: Radiotherapy is potentially curative in early stages of follicle center lymphoma. Frequent side effects are pancytopenia, nausea and abdominal discomfort. A radiation-induced liver injury with serious clinical symptoms and changes in liver function is a rare complication. Case report: Whole abdomen was irradiated in a 49-year-old-patient with a centrocytic-centroblastic lymphoma, stage IA (localization: Left inguinal region). A total dose of 30 Gy was delivered in a weekly fractionation of five times 1.5 Gy. Kidneys were protected by shielding after a dose of 13.5 Gy, liver blocks were positioned after 25 Gy. During the last 2 days of therapy the patient presented with weight gain, ascites, dyspnoea and elevated liver enzymes. Diagnostics revealed hepatosphlenomegaly, ascites and an increased portosystemic pressure gradient. Liver biopsy specimen showed a veno-occlusive disease. Complete relief of symptomatology was achieved within 7 days following placement of a transjugular intrahepatic portosystemic stent-shunt (TIPSS), heparinization and diuretics. Liver enzymes are in the normal range. Conclusion: Veno-occlusive disease of the liver (VOD) is a very rare side effect of primary abdominal irradiation of follicle center lymphoma. This complication should be taken into consideration if a patient presents with upper right quadrant pain, ascites and elevation of liver enzymes especially within 4 months following radiotherapy. Genesis of veno-occlusive disease, diagnostics, therapy and a review of the literature are presented. (orig.) [German] Hintergrund: Die Strahlentherapie spielt bei der kurativen Behandlung der Fruehstadien follikulaerer Keimzentrumslymphome die entscheidende Rolle. Therapiebegleitende Nebenwirkungen sind haeufig Panzytopenie, Nausea und abdominelle Beschwerden. Eine radiogen induzierte Leberschaedigung mit klinisch manifester Symptomatik und schwerer Leberfunktionsstoerung ist dagegen aeusserst selten. Fallbeschreibung: Bei einem 49

Úvod do finančních derivátů se zaměřením na SWAPY

OpenAIRE

Staněk, Kamil

2013-01-01

AB S T R A C T This thesis deals principally with swaps; however, for a complex understanding, there are some general chapters regarding financial derivatives included therein. The thesis proceeds from a historic-theoretical doctrine of financial derivatives. Besides the substance, essence, purpose and categorization of financial derivatives, the emphasis is laid in this theoretical part of the thesis on the legal status of financial derivatives. Under Czech law, financial derivatives are not...

Peripheral Blood stem cell transplantation in children with Beta-thalassemia major

International Nuclear Information System (INIS)

Farzana, T.; Shamsi, T.S.; Irfan, M.; Ansari, S.H.; Baig, M.I.; Shakoor, N.

2003-01-01

Objective: To share the preliminary data on stem cell transplantation in Pakistan. Results: Engraftment was achieved in all patients except one who required a second dose of bone marrow graft on day +21. Median time to achieve absolute neutrophil count of > 0.5 x 10/sup 9/ /l was 9.0 days (range 8 - 31 days) and platelet count of > 20 x 10/sup 9/ /l was 14 days (12 - 35 days). Acute GVHD was seen in 3 patients, one patient had grade IV gut GVHD; another patient had grade III gut GVHD while third patient had grade II skin GVHD. Median hospital stay was 29 days. Six patients were well and transfusion independent 3 to 36 months post transplant. One episode of primary graft failure required a second dose of bone marrow harvest. Another episode of graft rejection received two doses of donor lymphocytes infusion. There were 4 deaths due to grade IV gut GVHD because of uncontrolled systemic Candida infection and one due to hepatic veno-occlusive (VOD) disease. Conclusion: Allogeneic peripheral blood stem cell transplantation can be safely and economically carried out in Pakistan. Although there had been 4 deaths during 36 months follow-up, with increasing understanding and experience the outcome is expected to improve. (author)

Flexibility in Management of Modernization in Construction - Electrical Works/ Elastyczność W Zarządzaniu Modernizacją Obiektów Budowlanych Na Przykładzie Robót Elektrycznych

Science.gov (United States)

Nowotarski, Piotr; Pasławski, Jerzy

2015-06-01

The article presents the general principles of flexible approach, illustrated with case study regarding flexibility in modernization. Flexibility is understood in the present case as a skilful adaptation to changes in the dynamically changing environment. The essence of flexibility approach is being staged to make decisions based on environmental and process monitoring in progress. Presented case study of upgrading the electrical system in the multi-family housing in the common area is based on step by step procedure responding to damage state of this system. Simple analysis is based on cost comparison but there are other criteria (environmental, social etc.) and conflict solving situations taken into account in presented paper. Artykuł prezentuje możliwość zastosowania elastyczności w modernizacjach istniejących obiektów budowlanych na przykładzie instalacji oświetleniowej. Elastyczność jest rozumiana w tym przypadku jako umiejętne dostosowanie się do zmian w dynamicznie zmieniającym się środowisku. Istotą podejścia elastycznego jest podejmowanie odpowiednich decyzji w odpowiednim czasie opartych na monitoringu środowiska i procesu w toku. Prezentowane studium przypadku modernizacji instalacji elektrycznej w budownictwie wielorodzinnym w częściach wspólnych obiektu (korytarze, klatki schodowe, hala garażowa) opiera się na wymianie i modernizacji tylko tych punktów, które w danym momencie ulegają awarii. Prosta analiza oby typów modernizacji opiera się na porównaniu kosztów, natomiast trzeba zaznaczyć, że możliwe są także inne kryteria (środowiskowe, konfliktu społecznego, itp.), które będą przedmiotem kolejnych publikacji. Zastąpienie tradycyjnych żarówek rozwiązaniami opartymi na technologii LED z zastosowaniem czujników ruchu może prowadzić do znacznych oszczędności, ale może też oznaczać obniżenie komfortu dla użytkowników (np. dla osób starszych, którym jeden cykl działania oświetlenia nie jest

Use of Biochemical Markers for the Assessment of Organic Pollutant Contamination of the Vltava river, Czech Republic

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Marcela Havelková

2009-01-01

Full Text Available In this study, selected biochemical markers - cytochrome P450 (CYP 450, ethoxyresorufin-O-deethylase (EROD, glutathione S-transferase (GST and glutathione (GSH - were measured in chub (Leuciscus cephalus L. liver samples obtained from three locations on the Vltava river (Podolí, Podbaba and Vraňany and from a control location nmicals commonly known as their inducers. These include polychlorinated biphenyls, hexachlorobenzene and octachlorostyrene measured in chub muscle and polyaromatic hydrocarbons measured in bear Vodňany. The levels of selected biomarkers should correlate with the concentration of cheottom sediments obtained from the same locations. The highest EROD activity (median 101.37 pmol min-1 mg-1 protein, GST activity (median 42.82 nmol min-1 mg-1 protein, and GSH concentration (median 8.01 nmol mg-1 protein were found in fish liver from the Podbaba location. There were no significant differences in CYP P450 level or EROD activity among the different locations. In Podbaba, GST activity (P P < 0.001 were significantly higher than in the control location. The results of these analyses were correlated and a significant correlation was found between biochemical markers and their inducers. The results show that the use of biochemical markers in water quality assessment is a convenient method that can supplement classical chemical monitoring.

Optic Fibers as a Broadcasting Media

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Jusuf QARKAXHIJA

2018-04-01

Full Text Available Fast brodcasting of an information is always a challange from our daily activities. Through fast broadcasting of the information always created pre-eminence in military activities, business, researching, etc. From ancient times we know that information was orally and hand in hand broadcasted which in most of the times casused in loss of information and due to this also in loss of activities which are mentioned above. Due to information technology notably computer networks and internet overtime information started broadcasting faster. Information started broadcasting through copper wires and through wireless. Big applications started to develop with the increased use of Internet, high quality broadcasting (HD, video on demand broadcasting (VoD, triple pay broadcasting (three services on a medium, etc., then these two mediums couldn’t complete all these requests. Therfore after these problems, optic fiber began to be used as a broadcasting medium which eleminated all the defects of other mediums. Importance of this paper work is telling developing stages of optic fiber, it’s characteristics and it’s losses. Then it is shown that which devises enforce the signal of fibers and in the end all three mediums that we mentioned are compared on the basis of attributes. Findings form the paper will only enforce that knowledge we had before about optic fiber, the best broadcasting medium.

Development of Modern Marathons and Distance Running

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Sasho Belovski

2014-07-01

Moderní marathon a distanční běh zažívají výrazný rozmach a přitahují stále větší zájem všech zainteresovaných osob – stakeholderů běžeckého sportu. Můžeme však konstatovat, že mezi aktivními běžci jakož i mezi dalšími lidmi, kteří jsou přímo či nepřímo s distančním během spojeni, nejsou vědomosti o jeho současném rozvoji příliš hluboké. Tato práce chce nabídnout vybrané, zásadní události moderní historie distančního běhu, a sloužit tak nejen zaníceným aktivním běžcům a organizátorům běžeckých závodů, ale též historikům, studentům a akademikům jako zdroj užitečných informací a základ pro budoucí vědeckou činnost.

Soil nematodes (Nematoda) in the Voděradské bučiny National Nature Reserve (Czech Republic) - an overall characterization of the fauna

Czech Academy of Sciences Publication Activity Database

Háněl, Ladislav

2015-01-01

Roč. 79, č. 3 (2015), s. 215-234 ISSN 1211-376X R&D Projects: GA ČR(CZ) GA206/93/0276 Institutional support: RVO:60077344 Keywords : soil zoology * ecology * Nematoda * diversity Subject RIV: EH - Ecology, Behaviour

Dekontaminace podzemní vody obsahující terc-butylmethyleter a aromatické uhlovodíky fotolýzou peroxidu vodíku

Czech Academy of Sciences Publication Activity Database

Šabata, Stanislav; Lehnert, Radek; Karban, Jindřich; Hetflejš, Jiří; Kuncová, Gabriela

2008-01-01

Roč. 102, č. 12 (2008), s. 1115-1120 ISSN 0009-2770 R&D Projects: GA ČR(CZ) GA104/05/2637; GA AV ČR IAA400720703 Institutional research plan: CEZ:AV0Z40720504 Keywords : terc-butylmethylether * photolysis of H2O2 * decontamination of ground water Subject RIV: CC - Organic Chemistry Impact factor: 0.593, year: 2008

Využití separačních metod pro studium biologicky aktivních látek ve vodách

OpenAIRE

Vydrová, Lucie

2011-01-01

Léčiva patří mezi biologicky aktivní látky, které se odlišují různými funkčními skupinami, fyzikálně-chemickými a biologickými vlastnostmi. Tyto chemické látky, v současnosti zařazované mezi „nové“ kontaminanty, se kumulují v různých složkách životního prostředí. Do životního prostředí se dostávají v průběhu jejich průmyslové výroby, dále v důsledku používání v léčebných zařízeních nebo v domácnostech. Protože se jedná o látky biologicky aktivní, mohou v různých složkách životního prostředí n...

Kombinované foto- a elektrochemické zpracování odpadních vod obsahující nitro- a aminosloučeniny

OpenAIRE

Krystyník, Pavel

2013-01-01

Electrocoagulation is a very effective method for inorganic pollutants removal from water. It is possible to remove more than 95 % of inorganic pollutants depending on pH and current density. Photochemical oxidation is able to remove all organic compounds from water depending mainly on hydrogen peroxide concentration. Electrocoagulation also contributes to reduce the content of organic compounds so it decreases the hydrogen peroxide consumption in the oxidative treatment.

Nanočástice nulamocného železa pro čištění odpadních vod z galvanotechniky

Czech Academy of Sciences Publication Activity Database

Matysíková, J.; Sukopová, M.; Godoy Alonso, Paula; Holba, Marek

2014-01-01

Roč. 17, č. 2 (2014), s. 26-28 ISSN 0551-7354 R&D Projects: GA MPO FR-TI3/196 Institutional support: RVO:67985939 Keywords : nanoiron * wastewater * surface treatment industry Subject RIV: DJ - Water Pollution ; Quality

Korean efforts for education and training network in nuclear technology

International Nuclear Information System (INIS)

Han, Kyong-Won; Lee, Eui-Jin

2007-01-01

education programs along with a career in the nuclear fields at home and abroad should raise young generation's interests. Global network will serve as a vehicle that drives nuclear education and training forward. NTC of KAERI has developed the ANENT temporary web site (www.anent-temp.org) for the IAEA Consultancy Meting on Establishment of ANENT held in June 2003 at KAERI. According to the results from the discussion of the meeting, KAERI has requested to continue to work toward establishment of a web site for all activities related to ANENT. The followings are KAERI's efforts made for the ANENT: Installation of a portable cyber education system (Edu-V producer) and cyber studio for the effective production of VOD materials; Production of VOD type learning materials: 3 IAEA courses containing 52 lectures. For the progress of the establishment of ANENT, it is believed that exchange of informational and materials on education and training should be considered in advance among the member states. The followings are our suggestions for the exchange of information and materials to be discussed among member states: Formulation of a working group; Identification of the scope of activities; Establishment of cooperative mechanism; Design of ANENT web, and loading of existing information and materials on the web; Production and loading of new materials including cyber education and training materials; Sustainable operation of ANENT web site

Purists, Partisans, and the Aesthetic Dimension of Sport

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Charles Robinson

2014-05-01

Full Text Available Purists, Partisans, and the Aesthetic Dimension of Sport Stephen Mumford, in his book Watching Sport, identifies two types of sports spectator – partisans and purists. Partisans are more concerned to see their team win, whether they do so in an aesthetically pleasing way or not, while purists have no such irrational commitment, and instead pursues the higher aesthetic experience of sport. The purist, Mumford argues, is superior because she watches sport for aesthetic and intellectual reasons and sees the game, it seems, more objectively, whereas the partisan is emotional and victoryseeking, experiencing the game through the lens of their desire for victory. But this distinction, I argue, doesn’t do justice to the actual experience of spectators. Whilst Mumford is correct to suggest that the aesthetic dimension is vital in our enjoyment of sport, there is no reason to suppose that the partisan cannot partake in the aesthetic appreciation of sport. Furthermore, whilst winning is obviously hugely important in judging the quality of sports teams, they are likely to be more fondly regarded if they do so through the demonstration of virtues that are aesthetic in nature. Even the most vociferous of partisans are capable of appreciating such teams. Puristé, partyzáni a estetická dimenze sportu Ve své knize Watching Sport Stephen Mumford identifikuje dva typy sportovních diváků – partyzány a puristy. Partyzáni se zajímají spíše o výhru svého týmu, ať už je jejich hra estetická, nebo ne, zatímco puristé nemají tento iracionální zájem a zajímá je vyšší estetický sportovní zážitek. Mumford považuje puristy za nadřazenější, protože sledují sport z estetických a intelektuálních důvodů, a zdá se, že vidí hru objektivněji, zatímco partyzáni jsou emocionální a sledují hru skrze touhu po vítězství. Moje argumenty ukazují, že toto pojetí adekvátně nepopisuje zážitek diváků. Zatímco Mumford

Obhajoba umírněné optimalizace: O struktuře principů jako interpersonálních důvodů

Czech Academy of Sciences Publication Activity Database

Pavlakos, George

2017-01-01

Roč. 156, č. 10 (2017), s. 870-883 ISSN 0231-6625 R&D Projects: GA ČR GA15-23955S Institutional support: RVO:68378122 Keywords : proportionality * optimalization * normative reasons Subject RIV: AG - Legal Sciences OBOR OECD: Law

MDP-based resource allocation for triple-play transmission on xDSL systems

Science.gov (United States)

de Souza, Lamartine V.; de Carvalho, Glaucio H. S.; Cardoso, Diego L.; de Carvalho, Solon V.; Frances, Carlos R. L.; Costa, João C. W. A.; Riu, Jaume Rius i.

2007-09-01

Many broadband services are based on multimedia applications, such as voice over internet protocol (VoIP), video conferencing, video on demand (VoD), and internet protocol television (IPTV). The combination "triple-play" is often used with IPTV. It simply means offering voice, video and data. IPTV and others services uses digital broadband networks such as ADSL2+ (Asymmetric Digital Subscriber Line) and VDSL (Very High Rate DSL) to transmit the data. We have formulated a MDP (Markov Decision Process) for a triple-play transmission on DSL environment. In this paper, we establish the relationship between DSL transmission characteristics and its finite-state Markov model for a triple-play transmission system. This relationship can be used for a resource management for multimedia applications delivered through a broadband infrastructure. The solution to our optimization problem can be found using dynamic programming (DP) techniques, such as value iteration and its variants. Our study results in a transmission strategy that chooses the optimal resource allocation according the triple-play traffic requirements, defined in technical report TR-126 (Triple-Play Services Quality of Experience Requirements) from DSL Forum, minimizing quality of service (QoS) violations with respect to bandwidth. Three traffic classes (video, audio, and best effort internet data) are defined and analyzed. Our simulation results show parameters like as blocking probability for each class, link utilization and optimal control policies. The MDP-based approach provides a satisfactory way of resource management for a DSL system.

Digital Media Platforms and the Use of TV Content: Binge Watching and Video-on-Demand in Germany

Directory of Open Access Journals (Sweden)

Lothar Mikos

2016-07-01

Full Text Available The advancing digitalization and media convergence demands TV broadcasting companies to adjust their content to various platforms and distribution channels. The internet, as convergent carrier medium, is increasingly taking on a central role for additional media. Classical linear TV is still important, but for some audiences it has been developing from a primary medium to a secondary medium. Owing to the growing melding of classical-linear TV contents with online offerings (e.g. video-on-demand platforms or Web–TV, a great dynamic can be seen which has triggered numerous discussions about the future of TV for some time now. This article will summarize the results of two different audience studies. Film and television shows are meanwhile distributed online via Video-on-Demand platforms such as Netflix or Amazon Prime Video. The first audience study has dealt with the use of VoD-platforms in Germany investigating user rituals, user motivation to watch films and TV shows on these platforms, and the meaning of VoD in everyday life. Most of the participants in this study reported that they mainly watch TV drama series at Netflix or Amazon Prime. Therefore, the second audience study focused the online use of television drama series of individuals and couples elaborating the phenomenon of binge watching. In relating the audience practice to the new structures of the television market the article will shed light on the future of television.

Fire and Deforestation Dynamics in South America over the Past 50 Years

Science.gov (United States)

van Marle, M.; Field, R. D.; van der Werf, G.

2015-12-01

Fires play an important role in the Earth system and are one of the major sources of greenhouse gases and aerosols. Satellites have been key to understand their spatial and temporal variability in space and time, but the most frequently used satellite datasets start only in 1995. There are still large uncertainties about the frequency and intensity of fires in the pre-satellite time period, especially in regions with active deforestation, which may have changed dramatically in intensity in the past decades influencing fire dynamics. We used two datasets to extend the record of fires and deforestation in the Amazon region back in time: 1) annual forest loss rates starting in 1990 derived from Vegetation Optical Depth (VOD), which is a satellite-based vegetation product that can be used as proxy for forest loss, and 2) horizontal visibility as proxy for fire emissions, reported by weather stations and airports in the Amazon, which started around 1940, and having widespread coverage since 1973. We show that these datasets overlap with fire emission estimates from the Global Fire Emissions Database (GFED) enabling us to estimate fire emissions over the last 50 years. We will discuss how fires have varied over time in this region with globally significant emissions, how droughts have influenced fire activity and deforestation rates, and what the impact is of land-use change caused by fire on emissions in the Amazon region.

Țările române în sistemul relațiilor diplomatice medievale

Directory of Open Access Journals (Sweden)

Silvia DULSCHI

2016-09-01

Full Text Available Elementul de bază al aparatului diplomatic medieval al Ţărilor Române l-au reprezentat solii. În categoria selectă a solilor intrau oameni distinşi, cultivaţi, fini, rafinaţi. Cunoşteau limbile de circulaţie ale timpului, bunele maniere, arta conversaţiei, dar şi arta mânuirii sabiei. Istoria a reţinut numele unor soli celebri, cum ar fi Ion Ţamblac - solul lui Ştefan cel Mare, Luca Cârje - solul lui Ştefăniţă Vodă, banul Mihalcea - solul lui Mihai Viteazul, David şi Teodor Corbea - solii lui Constantin Brâncoveanu sau Nicolae Milescu Spătarul - solul ţarului rus Aleksei Mihailovici în îndepărtata Chină. Prin materialul de față ne propunem să aducem în atenţie figura mai puţin cunoscută a paharnicului Ion Caraiman - solul la Constantinopol al familiei domnitoare a Movileştilor, la sf. sec. al XVI-lea şi începutul sec. al XVII-lea, a cărui activitate diplomatică de succes a fost apreciată nu numai de demnitarii otomani, ci şi de ambasadorii unor mari puteri la Constantinopol, care scriau în repetate rânduri în rapoartele lor despre realizările sale.

Nuclear Manpower Training

International Nuclear Information System (INIS)

Han, K. W.; Lee, H. Y.; Lee, E. J. and others

2004-12-01

Through the project on nuclear human resources development in 2004, the Nuclear Training Center of KAERI has provided various nuclear education and training courses for 1,962 persons from the domestic nuclear related organizations such as Government Agencies, nuclear industries, R and D institutes, universities, and public as well as from IAEA Member States. The NTC has developed education programs for master/doctorial course on advanced nuclear engineering in cooperation with the University of Science and Technology which was established in 2003. Additionally, nuclear education programs such as nuclear technical training courses for the promotion of cooperation with member countries, have developed during the project period. The center has also developed and conducted 7 training courses on nuclear related technology. In parallel, the center has produced 20 training materials including textbooks, 3 multi-media education materials, and 56 Video On Demand (VOD) cyber training materials. In order to promote international cooperation for human resources development, the NTC has implemented a sub-project on the establishment of a web-portal including database for the exchange of information and materials within the framework of ANENT. Also, the center has cooperated with FNCA member countries to establish a model of human resources development, as well as with member countries on bilateral cooperation bases to develop training programs. The International Nuclear Training and Education Center (INTEC), which was opened in 2002, has hosted 318 international and domestic events (training courses, conferences, workshops, etc.) during the project period

Testing and reference model analysis of FTTH system

Science.gov (United States)

Feng, Xiancheng; Cui, Wanlong; Chen, Ying

2009-08-01

With rapid development of Internet and broadband access network, the technologies of xDSL, FTTx+LAN , WLAN have more applications, new network service emerges in endless stream, especially the increase of network game, meeting TV, video on demand, etc. FTTH supports all present and future service with enormous bandwidth, including traditional telecommunication service, traditional data service and traditional TV service, and the future digital TV and VOD. With huge bandwidth of FTTH, it wins the final solution of broadband network, becomes the final goal of development of optical access network.. Fiber to the Home (FTTH) will be the goal of telecommunications cable broadband access. In accordance with the development trend of telecommunication services, to enhance the capacity of integrated access network, to achieve triple-play (voice, data, image), based on the existing optical Fiber to the curb (FTTC), Fiber To The Zone (FTTZ), Fiber to the Building (FTTB) user optical cable network, the optical fiber can extend to the FTTH system of end-user by using EPON technology. The article first introduced the basic components of FTTH system; and then explain the reference model and reference point for testing of the FTTH system; Finally, by testing connection diagram, the testing process, expected results, primarily analyze SNI Interface Testing, PON interface testing, Ethernet performance testing, UNI interface testing, Ethernet functional testing, PON functional testing, equipment functional testing, telephone functional testing, operational support capability testing and so on testing of FTTH system. ...

Fentonova degradace antibiotik a jiných léčiv v odpadních vodách - vliv železnatých spinelů.

Czech Academy of Sciences Publication Activity Database

Pokorná, Dana; Cuřínová, Petra; Šnajdaufová, Hana; Křenek, T.; Pola, M.; Novák, L.; Janeček, V.; Pola, Josef

2016-01-01

Roč. 2016, č. 3 (2016), s. 154-165 ISSN 1804-0195 R&D Projects: GA TA ČR TA04020860 Institutional support: RVO:67985858 Keywords : antibiotics * Fenton degradation * waste water Subject RIV: CF - Physical ; Theoretical Chemistry http://www.wasteforum.cz/cisla/WF_3_2016.pdf

Internetový marketing v cestovním ruchu - případová studie vodácké půjčovny Hastrman

OpenAIRE

Kronďáková, Ivana

2013-01-01

The theory part of the thesis discusses internet marketing, its development and specifics. In addition, it discusses individual tools of internet marketing and measuring of their efficiency. The practical part focuses on using internet marketing in tourism, using as a case study Hastrman Boat Rental. Marketing activities of the rental place and of its competitors are analysed. On the basis of the theory findings acquired and the analysis made, a marketing strategy is proposed for the selected...

Triple play service under the impact of nonstationary noise in a DSL system: an Amazon approach

Science.gov (United States)

de Souza, Lamartine V.; Cardoso, Diego; Silva, Marcelino; Seruffo, Marcos; Francês, Carlos R. L.; Costa, João C. W. A.; Castro, Agostinho L. S.; Cavalcante, Gervásio; Rius i Riu, Jaume

2007-09-01

The Brazilian Amazon has sui generis characteristics that affect strongly the communication technologies, such as high humidity and temperature. These characteristics cause impact in the existent infrastructure, especially in twisted-pair copper lines. At the moment, new services are based on multimedia applications, as voice over internet protocol (VoIP), video on demand (VoD), and internet protocol television (IPTV). Such services use digital broadband networks such as ADSL2+ (Asymmetric Digital Subscriber Line) to transmit the data. Broadband services require data rates which can only be achieved by using relatively high spectrum frequencies. At high frequencies the DSL signal is more susceptible to external noise sources, such as radio frequency interference and impulsive noise. For this purpose, an experimental setup has been built at UFPA that consists of noise generator, traffic generator, real cables, modems and DSLAM (digital subscriber line access multiplexer). This paper aims at characterizing how the noise impacts on triple play services for a broadband system using a DSL loop on Amazon environment. The objective of the noise impact experimentation is to observe the behavior of a DSL system under more realistic but controlled line conditions. Metrics as lost packet, jitter, latency, and throughput are used to characterize the triple play service in a DSL loop under the noise impact. Through the real experiments and controlled loop conditions, this paper allow identify, from application level point of view, how robust DSL system is in respect to noise occurrence. Additionally, it is described a methodology for noise impact measurements using a DSL system.

Satellite Soil Moisture and Water Storage Observations Identify Early and Late Season Water Supply Influencing Plant Growth in the Missouri Watershed

Science.gov (United States)

A, G.; Velicogna, I.; Kimball, J. S.; Du, J.; Kim, Y.; Colliander, A.; Njoku, E. G.

2017-12-01

We employ an array of continuously overlapping global satellite sensor observations including combined surface soil moisture (SM) estimates from SMAP, AMSR-E and AMSR-2, GRACE terrestrial water storage (TWS), and satellite precipitation measurements, to characterize seasonal timing and inter-annual variations of the regional water supply pattern and its associated influence on vegetation growth estimates from MODIS enhanced vegetation index (EVI), AMSR-E/2 vegetation optical depth (VOD) and GOME-2 solar-induced florescence (SIF). Satellite SM is used as a proxy of plant-available water supply sensitive to relatively rapid changes in surface condition, GRACE TWS measures seasonal and inter-annual variations in regional water storage, while precipitation measurements represent the direct water input to the analyzed ecosystem. In the Missouri watershed, we find surface SM variations are the dominant factor controlling vegetation growth following the peak of the growing season. Water supply to growth responds to both direct precipitation inputs and groundwater storage carry-over from prior seasons (winter and spring), depending on land cover distribution and regional climatic condition. For the natural grassland in the more arid central and northwest watershed areas, an early season anomaly in precipitation or surface temperature can have a lagged impact on summer vegetation growth by affecting the surface SM and the underlying TWS supplies. For the croplands in the more humid eastern portions of the watershed, the correspondence between surface SM and plant growth weakens. The combination of these complementary remote-sensing observations provides an effective means for evaluating regional variations in the timing and availability of water supply influencing vegetation growth.

THE ASSESSMENT OF BIOLOGICAL MARKERS IN PATIENTS WITH PREECLAMPSIA WHEN AN INFLAMMATORY PROCESS APPEARS

Directory of Open Access Journals (Sweden)

Eduard Crauciuc

2015-07-01

Full Text Available Preeclampsia represents a pathological state that is specific to regnancy, is characterized by high blood pressure de novo and significant proteinuria and appears after 20 weeks of pregnancy. The continuously increasing mortality caused by preeclampsia in our country totally justifies the fact that all efforts are directed towards primary and secondary prevention of the disease and underlines the necessity of urgent intervention at population level, together withthe implementation of a screening programme that is able to reduce the impact of this condition on the mother and the baby. The cases were gathered between 2003 and 2014. The patients were selected by studying the observation charts of the pregnant women hospitalized in ”Cuza Vodă” Clinical Hospital of Obstetrics and Gynecology Iaşi, having a pregnancy over 20 weeks, who came for a specialized consult and who were harvested CRP, without an infectious context or prematurely and spontaneously ruptured membranes. The comparison of the lab markers for the pregnantwomen with severe preeclampsia, depending on the plasmatic level of CRP over 12 mg/l, showed significantly higher values of fibrinogen, LDH, GOT, GPT, serum blood urea nitrogen, creatinine and urine proteins, while the mean number of white cells was significantly reduced (p<0,05. The study confirms the change in the inflammatory process markers, the hepatic and kidney function, associated with a high plasmatic level of CRP for pregnant women with severe preeclampsia.

Research of application mode for FTTX technology

Science.gov (United States)

Wang, Zhong; Yun, Xiang; Huang, Wei

2009-08-01

With rapid development of Internet and broadband access network, the technologies of xDSL, FTTx+LAN, WLAN have more applications, new network service emerges in endless stream, especially the increase of network game, meeting TV, video on demand, etc. FTTH supports all present and future service with enormous bandwidth, including traditional telecommunication service, traditional data service and traditional TV service, and the future digital TV and VOD. With huge bandwidth of FTTH, it wins the final solution of broadband network, becomes the final goal of development of optical access network. In this paper, technique theory of EPON is introduced at first. At the same time, MAC frame structure, automatic detection and ranging of MPCP, DBA,and multi-LLID of EPON is analyzed. Then, service development ability, cost advantage and maintenance superiority based on EPON technology are carried out. At last,with Cost comparison between FTTH / FTTB building model and the traditional model, FTTB + LAN mode which is suitable for the newadding residential users in general areas and FTTN + DSL mode which is suitable for the old city and rural access network transformation are built up in detail. And FTTN + DSL project of rural information in rural areas and FTTH broadband HOUSE project on service solutions program are analyzed. comparing to the traditional access technologies, EPON technology has the obvious advantages, such as distance transmission, high or wide band, saving line resources, service abilities, etc. These are the qualities which not only be served for home users, but solve more access problems for us effectively.

Pohybové aktivity ve vodě pro seniory a jejich vliv na zdraví s využitím intervenčního programu.

OpenAIRE

PRAŽÁK, Jaromír

2012-01-01

Old age is a natural and irreversible process of human development, which is associated with significant physiological, psychological and social changes. Active life of seniors and implementation of adequate physical activity is the cornerstone for achieving high-quality, healthy and full of life. The aim of this study was to develop, validate and identify practical physical and mental changes related to the intervention program and processed at the same time integrating the program into dail...

Aktywność fizyczna w terapii otyłości

Directory of Open Access Journals (Sweden)

Joanna Zapolska

2009-03-01

Full Text Available Otyłość jest chorobą określaną jako patologiczne zwiększenie ilości tkanki tłuszczowej, która w nadmiernej ilości wpływa negatywnie na stan zdrowia, długość życia i sprawność psychofizyczną. Osoby z nadmierną masą ciała, w której zawartość tłuszczu stanowi proporcjonalnie wysoki odsetek, w porównaniu z osobami o niższej masie ciała są fizjologicznie mniej wydolni, a ich potencjał motoryczny jest niższy. W otyłości u osób dorosłych dochodzi przede wszystkim do zwiększenia rozmiarów komórek tłuszczowych. W przypadku dzieci obserwujemy przyrost liczby komórek tłuszczowych, które mogą się przyczynić do rozwoju otyłości w wieku dorosłym, gdyż zwiększenie liczby komórek jest procesem nieodwracalnym. Często rodzice aż do momentu wystąpienia znacznej otyłości nie postrzegają nadmiernej masy ciała dziecka w kategoriach problemu zdrowotnego. Istotna staje się więc rola służby zdrowia w prowadzeniu działań prewencyjnych, skierowanych na działania np. fitness clubów odpowiednio przygotowanych do podejmowania tego typu zadań. Ogólnie przyjęte zasady dawkowania ćwiczeń w treningu zdrowotnym fitness osób dorosłych oraz dzieci i młodzieży są podobne. Różnią się czasem trwania, częstotliwością podejmowania aktywności oraz stosowanymi obciążeniami. Treningi fitness obejmują głównie wytrzymałościowe formy ćwiczeń, takie jak ćwiczenia aerobowe na urządzeniach typu cardio mające za zadanie przede wszystkim uaktywnić i zredukować nadmiar tkanki tłuszczowej. Inną formą zajęć usprawniających powinny być ćwiczenia oporowe uwzględniające stosowanie urządzeń izotonicznych. Należy przy tym zwrócić szczególną uwagę na dobór ćwiczeń, obciążenie oraz kontrolę postępów. Równocześnie zaleca się stosowanie monitoringu zakresów HR każdej sesji treningu aerobowego i oporowego. Jako uzupełnienie proponowane są ćwiczenia gibkościowe wykonywane jako �

Investigation of targeted pyrrolizidine alkaloids in traditional Chinese medicines and selected herbal teas sourced in Ireland using LC-ESI-MS/MS.

Science.gov (United States)

Griffin, Caroline T; Gosetto, Francesca; Danaher, Martin; Sabatini, Stefano; Furey, Ambrose

2014-01-01

Publications linking hepatotoxicity to the use of herbal preparations are escalating. Herbal teas, traditional Chinese medicines (TCMs) and dietary supplements have been shown to contain pyrrolizidine alkaloids (PAs). Acute PA toxicosis of the liver can result in sinusoidal-obstruction syndrome, also known as veno-occlusive disease (VOD). This paper describes a sensitive and robust method for the detection of targeted PAs and their N-oxides (PANOs) in herbal products (selected herbal teas and TCMs) sourced within Ireland. The sample preparation includes a simple acidic extraction with clean-up via solid-phase extraction (SPE). Sample extracts were accurately analysed by using LC-ESI-MS/MS applying for the first time a pentafluorophenyl (PFP) core-shell column to the chromatographic separation of PAs and PANOs. The method was validated for selectivity, taking into consideration matrix effects, specificity, linearity, precision and trueness. Limits of detection (LOD) and limits of quantitation (LOQ) were quantified for all PAs and PANOs ranging from 0.4 to 1.9 µg kg⁻¹ and from 1.3 to 6.3 µg kg⁻¹, respectively. In this study 10 PAs and four PANOs were targeted because they are commercially available as reference standards. Therefore, this study can only report the levels of these PAs and PANOs analysed in the herbal teas and TCMs. The results reported represent the minimum levels of PAs and PANOs present in the samples analysed; commercially available herbal teas (n = 18) and TCMs (n = 54). A total of 50% herbal teas and 78% Chinese medicines tested positive for one or more PAs and/or PANOs included within this study, ranging from 10 to 1733 and from 13 to 3668 µg kg⁻¹, respectively.

Leonarda Huntpichlera návod ke kázání kříže proti českým kacířům

Czech Academy of Sciences Publication Activity Database

Soukup, Pavel

2016-01-01

Roč. 56, č. 1 (2016), s. 65-80 ISSN 0323-0562 R&D Projects: GA ČR(CZ) GBP405/12/G148 Institutional support: RVO:67985955 Keywords : Hussite Wars * crusade * preaching * Austria Subject RIV: AB - History http://hdl.handle.net/11104/0260505

Modelování průtoků a vybraných parametrů jakosti vod na povodí Jenínského potoka modelem SWAT

OpenAIRE

HOMOLKA, Jan

2014-01-01

The thesis continues with the bachelor thesis which had dealt with preparation bases for simulation draining and carrying materials in SWAT model. Simulation should have been realized within basin of the Jenín stream, which watershed is 4,65 km2 large. SWAT model is primary developed for the larger watersheds where simulated values doesn't attain tolerances. Because of this is thesis focused on the methodic of simulation itself, discussion of the problem when is SWAT model almost useless for ...

Praktická aplikace techniky fotochemické oxidace H2O2/UVC pro čištění kontaminovaných podzemních vod

Czech Academy of Sciences Publication Activity Database

Mašín, P.; Krystyník, Pavel; Žebrák, R.

2015-01-01

Roč. 109, č. 11 (2015), s. 885-891 ISSN 0009-2770 R&D Projects: GA MPO(CZ) FR-TI1/065 Institutional support: RVO:67985858 Keywords : photochemical oxidation * hydrogen peroxide * ultraviolet irradiation Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 0.279, year: 2015

Úvod do problematiky výzkumu citlivých témat ve výběrových šetřeních

Czech Academy of Sciences Publication Activity Database

Chylíková, Johana

2011-01-01

Roč. 5, č. 2 (2011), s. 185-203 ISSN 1802-8152 R&D Projects: GA MŠk LA09010 Institutional research plan: CEZ:AV0Z70280505 Keywords : surveying in sociology * questionnaire * respondent Subject RIV: AO - Sociology, Demography http://dav.soc.cas.cz/issue/14-data-a-vyzkum-2-2011/66

Analysis of motives for mentoring students in practical pedagogical training [Analýza důvodů k mentoringu studentů během pedagogické praxe

Directory of Open Access Journals (Sweden)

Marjeta Kovač

2010-06-01

Full Text Available BACKGROUND: The main goals of the renovation of study programmes were, in the majority of the EU member states, the unification and conversion of programmes that will enable the development of the EU into one of the strongest knowledge based societies. Modern study programmes emphasise the interconnection of practice and theoretical principles, which students acquire during their studies; therefore, practical training is one of the most important key parts of all study programmes. Consequently, an efficient system of competent and quality mentorship plays an important part, as mentors prepare individuals for entering the job market by developing their specific competencies in an authentic environment. OBJECTIVE: As many European Union member states have not yet established a system of competent and quality mentorship, the study presents a system of measures for increasing the motivation of teachers for mentoring students and achieving a better quality of mentorship. The study examined motives for mentoring students in practical pedagogical training. METHODES: The research included 62 teachers, who mentored students of the Faculty of Sport. The questionnaire used included 26 different motives. Descriptive statistics and factorial analysis were used for data analysis. RESULTS: It has been revealed that mentors decide to mentor students during their pedagogical training in order to develop their own professional competencies and to further their career – to climb the professional ladder by acquiring additional points needed for advancing in the direction of a higher title. Both reasons result in a higher "status" in the work environment. CONCLUSIONS: It has been found that in future, a model of partnership cooperation should be established between the Faculty of Sport and mentoring schools; certain measures should also be introduced, facilitating higher motivation of mentors to carry out mentoring. Such measures would influence the practical pedagogical training of students to improve its quality and promote realistic preparation for working in a real work environment.[VÝCHODISKA: Hlavním cílem inovace studijních programů ve většině členských států EU byla unifikace a modernizace těchto programů, která umožní rozvoj EU v jednu z nejsilnějších znalostních společností. Moderní studijní programy zdůrazňují vzájemné spo jení teoretických principů, které si studenti osvojují během studia, s praxí z toho důvodu, že praktická příprava je jednou z nejdůležitějších částí všech studijních programů. Rovněž účinný systém kvalitních a kompetentních školitelů má významnou roli. Tito školitelé připraví jedince ke vstupu na trh práce právě rozvojem jejich specifických dovedností v autentickém prostředí. CÍLE: Z toho důvodu, že mnoho členských států EU ještě nevytvořilo systém kompetentních a kvalitních školitelů, prezentuje tato studie systém opatření k růstu motivace učitelů pro školení studentů a lepší kvalitu školitelské činnosti. Studie zkoumá motivy pro školení studentů v praktické přípravě. METODIKA: Výzkum zahrnoval 62 učitelů, kteří vyučovali na Fakultě sportu v Ljubljani. Použitý dotazník obsahoval 26 různých motivů. Pro zpracování dat byla využita deskriptivní statistika a faktoriální analýza. VÝSLEDKY: Výsledky ukázaly, že školitelé školí studenty v pedagogické praxi za účelem rozvoje svých vlastních profesních dovedností a z důvodu kariérních motivů – profesní postup v hierarchickém žebříčku získáváním dodatečných bodů umožňujících postup na vyšší profesní úroveň. Oba tyto důvody znamenají vyšší profesní postavení v pracovním prostředí. ZÁVĚRY: Bylo zjištěno, že by bylo potřeba vytvořit model partnerské spolupráce mezi fakultou sportu a vzdělávacími školami a prostřednictvím vhodných opatření zajistit větší motivaci školitelů k výkonu jejich školitelské činnosti. Tato opatření by ovlivnila lepší kvalitu praktické pedagogické přípravy studentů při práci v reálném pracovním prostředí.

Práce probíhající na vzorovém projektu monitoringu pro makroseizmické studie v předpokládaných lokalitách úložišť radioaktivního odpadu - lokalita Čertovka

Czech Academy of Sciences Publication Activity Database

Brož, Milan; Levý, O.; Štrunc, J.

2017-01-01

Roč. 24, č. 1 (2017), s. 12-21 ISSN 1803-1447 Institutional support: RVO:67985530 Keywords : earthquake * seismic network * induced seismicity * seismograph Subject RIV: DC - Siesmology, Volcanology, Earth Structure OBOR OECD: Volcanology

Vliv vybraných psychických faktorů na výkon závodníka ve vodním slalomu na divoké vodě

OpenAIRE

Kubričan, Pavel

2008-01-01

Title of diploma paper: The influence of chosen psychical factors on the performance of Competitor in wild water slalom. Aim: The aim of the work is based on the results of the questionnaire CSA-I 2 to determine the values of all three components Racing anxiety and their impact on the performance of the plant itself. Methods: To determine the values of competitive anxiety questionnaire was used CSAI-second results They were processed using the statistical program SPSS. The comparison was used...

Složení, zdroje a analýza ve vodě rozpustných organických sloučenin v atmosférických aerosolech

Czech Academy of Sciences Publication Activity Database

Kořínková, Alena; Mikuška, Pavel; Večeřa, Zbyněk

2014-01-01

Roč. 108, č. 7 (2014), s. 667-672 ISSN 0009-2770 R&D Projects: GA ČR(CZ) GAP503/11/2315; GA ČR(CZ) GBP503/12/G147; GA ČR GA13-01438S Institutional support: RVO:68081715 Keywords : water soluble organic compounds * atmospheric aerosol Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 0.272, year: 2014

Vývoj, optimalizace a validace analytické metody na stanovení polycyklických aromatických uhlovodíků ve vodě pomocí HPLC-PDA

Czech Academy of Sciences Publication Activity Database

Pilík, P.; Kahoun, D.; Šafařík, Ivo

2017-01-01

Roč. 15, č. 2 (2017), s. 92-94 ISSN 2336-7202 Institutional support: RVO:60077344 Keywords : polycyclic aromatic hydrocarbons * HPLC * Magnetic solid phase extraction Subject RIV: CB - Analytical Chemistry, Separation OBOR OECD: Analytical chemistry

On the Feasibility of Prefetching and Caching for Online TV Services: A Measurement Study on Hulu

Science.gov (United States)

Krishnappa, Dilip Kumar; Khemmarat, Samamon; Gao, Lixin; Zink, Michael

Lately researchers are looking at ways to reduce the delay on video playback through mechanisms like prefetching and caching for Video-on-Demand (VoD) services. The usage of prefetching and caching also has the potential to reduce the amount of network bandwidth usage, as most popular requests are served from a local cache rather than the server containing the original content. In this paper, we investigate the advantages of having such a prefetching and caching scheme for a free hosting service of professionally created video (movies and TV shows) named "hulu". We look into the advantages of using a prefetching scheme where the most popular videos of the week, as provided by the hulu website, are prefetched and compare this approach with a conventional LRU caching scheme with limited storage space and a combined scheme of prefetching and caching. Results from our measurement and analysis shows that employing a basic caching scheme at the proxy yields a hit ratio of up to 77.69%, but requires storage of about 236GB. Further analysis shows that a prefetching scheme where the top-100 popular videos of the week are downloaded to the proxy yields a hit ratio of 44% with a storage requirement of 10GB. A LRU caching scheme with a storage limitation of 20GB can achieve a hit ratio of 55% but downloads 4713 videos to achieve such high hit ratio compared to 100 videos in prefetching scheme, whereas a scheme with both prefetching and caching with the same storage yields a hit ratio of 59% with download requirement of 4439 videos. We find that employing a scheme of prefetching along with caching with trade-off on the storage will yield a better hit ratio and bandwidth saving than individual caching or prefetching schemes.

Sensitivity of the hypsometric integral (HI and its connections with lithology and neotectonics in the Rodna Mountains, Romanian Carpathians

Directory of Open Access Journals (Sweden)

Andrei ZAMOSTEANU

2015-10-01

Full Text Available This study investigates the sensitivity of the hypsometric integral (HI and its connections with lithology and neotectonics from northern Romanian Carpathians, Rodna Mountains. Two types of DEM was used in analysis (a 30m DEM resolution with specific grid size and a non-gridded 30m DEM resolution. Several methods have been applied in order to calculate HI as: the CalHypso GIS extension was used to automatically extract multiple hypsometric curves from digital elevation model (DEM and to calculate the main statistics related to the HI by applying polynomial fits; local indices of spatial autocorrelation were applied using Anselin Local Moran’s I and Getis-Ord Gi* in order to see if HI distribution has spatial patterns values and selection of valid squares (500m2 grid using 30m DEM using ArcMap 10.1 for the lithological analysis. The values of the hypsometric kurtosis density, kurtosis, skew and density skew are increasing eastwards. Values of hypsometric skewness for the northern slope are in range between 0.290 – 0.816 and sowthern part between 0.414 – 0.507. The results show that HI values are higher than 0.5 in the areas with recent tectonic influences especially in northern part near Dragoş Vodă fault system. The formations with a Oligocene, Miocene, Pleistocene and Holocene age have low values (<0.5 wile the other ones from Precambrian, Cambrian, Silurian, Eocene, Miocene and Pliocene age have higher values (>0.5. Comparing HI values from these two analysis (500m grid size DEM and the DEM without grid size of the DEM we find some slightly differences in HI values specially in the northern part of the range on Repedea, Negoiescu Mare, Fântâna and Lala basins

Sinusoidal Obstruction Syndrome (Hepatic Veno-Occlusive Disease)

Science.gov (United States)

Fan, Cathy Q.; Crawford, James M.

2014-01-01

Hepatic sinusoidal obstruction syndrome (SOS) is an obliterative venulitis of the terminal hepatic venules, which in its more severe forms imparts a high risk of mortality. SOS, also known as veno-occlusive disease (VOD), occurs as a result of cytoreductive therapy prior to hematopoietic stem cell transplantation (HSCT), following oxaliplatin-containing adjuvant or neoadjuvant chemotherapy for colorectal carcinoma metastatic to the liver and treated by partial hepatectomy, in patients taking pyrrolizidine alkaloid-containing herbal remedies, and in other particular settings such as the autosomal recessive condition of veno-occlusive disease with immunodeficiency (VODI). A central pathogenic event is toxic destruction of hepatic sinusoidal endothelial cells (SEC), with sloughing and downstream occlusion of terminal hepatic venules. Contributing factors are SEC glutathione depletion, nitric oxide depletion, increased intrahepatic expression of matrix metalloproteinases and vascular endothelial growth factor (VEGF), and activation of clotting factors. The clinical presentation of SOS includes jaundice, development of right upper-quadrant pain and tender hepatomegaly, ascites, and unexplained weight gain. Owing to the potentially critical condition of these patients, transjugular biopsy may be the preferred route for liver biopsy to exclude other potential causes of liver dysfunction and to establish a diagnosis of SOS. Treatment includes rigorous fluid management so as to avoid excessive fluid overload while avoiding too rapid diuresis or pericentesis, potential use of pharmaceutics such as defibrotide, coagulolytic agents, or methylprednisolone, and liver transplantation. Proposed strategies for prevention and prophylaxis include reduced-intensity conditioning radiation for HSCT, treatment with ursodeoxycholic acid, and inclusion of bevacizumab with oxaliplatin-based chemotherapeutic regimes. While significant progress has been made in understanding the pathogenesis

The Depths of the Ocean and the Question of Radioactive Waste Disposal in Them; Les Grandes Fosses Oceaniques et l'Immersion des Dechets Radioactifs dans ces Eaux Profondes; 0413 041b 0423 0414 ; Cuestiones Relacionadas con la Inmersion de Desechos Radiactivos en las Grandes Fosas

Energy Technology Data Exchange (ETDEWEB)

Bogorov, V. G.; Tareev, B. A.; Fedorov, K. N. [Oceanographical Institute of the Academy of Sciences of the USSR, Moscow, USSR (Russian Federation)

1960-07-01

experimentales realizadas en el Oceano Pacifico. Por consiguiente, debe admitirse que no se pueden evacuar desechos radiactivos en las fosas oceanicas profundas sin exponer a la poblacion del mundo entero a los peligros de la contaminacion radiactiva. (author) [Russian] V Mirovom okeane imeetsja 23 glubokovodnyh vpadiny s glubinami svyshe 6 km. Ni odna vpadina ne imeet nikakih morfologicheskih osobennostej, kotorye prepjatstvovali by svobodnomu vtekaniju i vytekaniju glubinnyh vod. Povyshenie temperatury vody po napravleniju ko dnu vpadiny, nachinaja s glubiny 3-5 km, javljaetsja prichinoj vertikal'nogo konvektivnogo peremeshivanija glubinnyh vod. Teoreticheski dokazano, chto, nesmotrja na stabilizirujushhij jeffekt vrashhenija zemli, ustojchivaja jacheistaja konvekcija dolzhna sushhestvovat' v glubinnyh slojah dazhe v sluchae ves'ma malyh sverhadiabaticheskih gradientov temperatury. Raspredelenie soderzhanija kisloroda po vertikali s harakternym vozrastaniem procenta nasyshhenija i absoljutnoj koncentracii O{sub 2} s glubinoj ot sloja minimuma (1000 m) do dna pozvoljaet predpolagat' nalichie ne tol'ko vertikal'nyh, no i gorizontal'nyh dvizhenij ili gorizontal'nogo peremeshivanija vo vsej tolshhe glubinnyh vod. V protivnom sluchae biohimicheskoe potreblenie kisloroda (ne menee 0,1 ml/l v god) privelo by k polnomu istoshheniju ego zapasov v glubinnyh vodah v sravnitel'no korotkij srok (40-60 let). Sushhestvovanie znachitel'nyh po skorosti (5-17 sm/sek) gorizontal'nyh techenij na glubinah 1000-3000 m bylo ustanovleno neposredstvennymi izmerenijami v Atlanticheskom i Tihom okeanah. Ne tol'ko cirkuljacija vod v fizicheskom smysle osushhestvljaet perenos rastvo rennyh i vzveshennyh veshhestv v okeane. Nepreryvnoe peremeshhenie zhivyh organizmov sozdaet dopolnitel'nuju ugrozu togo, chto radioaktivnye veshhestva, posle akkumuljacii ih v tkanjah zhivyh organizmov budut razneseny poslednimi i peredany po pishhevym cepjam na bol'shie rasstojanija i s bol'shoj skorost'ju, kak jeto uzhe

Studium proudění a zranitelnosti podzemních vod v karbonátech skupiny branné: vodohospodářsky významná oblast na Jesenicku

Czech Academy of Sciences Publication Activity Database

Kukačka, J.; Bruthans, J.; Zeman, Ondřej; Altová, V.

2005-01-01

Roč. 2004, - (2005), s. 163-165 ISSN 0514-8057 Grant - others:GAUK(CZ) 2001/197; FRVŠ(CZ) 2001/2066 Institutional research plan: CEZ:AV0Z3013912 Keywords : karst * vulnerability * Branná group * catchment area * watersupply Subject RIV: DB - Geology ; Mineralogy http://www.geology.cz/zpravy/obsah/2004/zpravy-o-vyzkumech-2004-str-163-165. pdf

Elektrické výboje ve vodě a jejich využití k čištění vody a v medicíně

Czech Academy of Sciences Publication Activity Database

Lukeš, Petr; Šunka, Pavel; Člupek, Martin; Babický, Václav; Hoffer, Petr; Šimek, Milan; Stelmashuk, Vitaliy

2009-01-01

Roč. 59, č. 4 (2009), s. 202-206 ISSN 0009-0700 R&D Projects: GA AV ČR IAAX00430802; GA ČR GA202/09/1151 Institutional research plan: CEZ:AV0Z20430508 Keywords : non-thermal plasma * electrical discharge * water treatment * biomedicine Subject RIV: BL - Plasma and Gas Discharge Physics

Poutník ze Země východní. Úvod do problematiky obsidiánové štípané industrie v Čechách

Czech Academy of Sciences Publication Activity Database

Burgert, Pavel

2014-01-01

Roč. 16, prosinec (2014), s. 25-28 ISSN 1213-1628 R&D Projects: GA MK(CZ) DF12P01OVV032 Keywords : Neolithic * obsidian * raw materials Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology

Vliv drenážních systémů na koncentrace dusičnanů v povrchových vodách v povodí VN Švihov

Czech Academy of Sciences Publication Activity Database

Lexa, M.; Kvítek, T.; Hejzlar, Josef; Fučík, P.

2006-01-01

Roč. 56, č. 8 (2006), s. 246-250 ISSN 1211-0760 Grant - others:VÚMOP(CZ) 0002704901; NAZV MZe(CZ) QF4062, QF3301 Institutional research plan: CEZ:AV0Z60170517 Keywords : nitrate * tile drainage * stream water Subject RIV: DJ - Water Pollution ; Quality

Aplikace centralizovaného telemetrického řídícího systému pro decentralizované čištění odpadních vod

Czech Academy of Sciences Publication Activity Database

Holba, Marek; Plotěný, K.; Sládek, R.; Tomšů, J.

2010-01-01

Roč. 60, č. 12 (2010), s. 347-349 ISSN 1211-0760 R&D Projects: GA MZe QH81012; GA MŠk 1M0571 Institutional research plan: CEZ:AV0Z60050516 Keywords : decentralized treatment * wastewater * centralized telemetric control system Subject RIV: EF - Botanics

Terrestrial Water Storage and Vegetation Resilience to Drought

Science.gov (United States)

Meyer, V.; Reager, J. T., II; Konings, A. G.

2017-12-01

The expected increased occurrences of hydrologic extreme events such as droughts in the coming decades motivates studies to better understand and predict the response of vegetation to such extreme conditions. Previous studies have addressed vegetation resilience to drought, defined as its ability to recover from a perturbation (Hirota et al., 2011; Vicente-Serrano et al., 2012), but appear to only focus on precipitation and a couple of vegetation indices, hence lacking a key element: terrestrial water storage (TWS). In this study, we combine and compare multiple remotely-sensed hydro-ecological datasets providing information on climatic and hydrological conditions (Tropical Rainfall Measuring Mission (TRMM), Gravity Recovery and Climate Experiment (GRACE)) and indices characterizing the state of the vegetation (vegetation water content using Vegetation Optical Depth (VOD) from SMAP (Soil Moisture Active and Passive), Gross Primary Production (GPP) from FluxCom and Specific Fluorescence Intensity (SFI, from GOSat)) to assess the ability of vegetation to face and recover from droughts across the globe. Our results suggest that GRACE hydrological data bridge the knowledge gap between precipitation deficit and vegetation response. All products are aggregated at a 0.5º spatial resolution and a monthly temporal resolution to match the GRACE Mascon product. Despite these coarse spatiotemporal resolutions, we find that the relationship between existing remotely-sensed eco-hydrologic data varies spatially, both in terms of strength of relationship and time lag, showing the response time of vegetation characteristics to hydrological changes and highlighting the role of water storage. A special attention is given to the Amazon river basin, where two well documented droughts occurred in 2005 and 2010, and where a more recent drought occurred in 2015/2016. References : Hirota, Marina, et al. "Global resilience of tropical forest and savanna to critical transitions." Science

Benign breast disease and the risk of breast cancer in the next 15 years.

Science.gov (United States)

Socolov, Demetra; Anghelache, Ivona; Ilea, C; Socolov, R; Carauleanu, A

2015-01-01

Fibrocystic mastosis (FCM) is defined by the totality of dystrophic changes of the mammary tissue, the grouping in the form of fibrosis of epithelial, cystic, metaplastic and hyperplastic alterations. A very good estimation of the cancer risk is related specifically to the microscopic aspect. Other factors, the family history as well as the presence of an inherited gene determining the increase in the risk of breast cancer are also considered. But, if a woman known with fibrocystic mastosis has not undergone any biopsy, then it is impossible to calculate the specific individual risk of developing cancer. The data collected as a study material and considered refer to: the total num- ber of cases investigated and diagnosed with fibrocystic mastosis, the annual distribution of this disease cases, the distribution of the cases according to age groups, admission reasons, clinical examination, personal pathologic history clinically significant for the basic disease (the main diagnosis), the family medical history significant for the basic disease, the anatomopathological diagnosis. Between 2004 and 2006, at "Cuza Vodă" Obstetrics and Gynecology Hospital of Iaşi, a maximum number of cases is noticed in 2006, when there were 147 cases, and the lowest number of cases was in 2005. There was high frequency of the anatomopathological examinations that highlighted the presence of fibrocystic lesions (both proliferative and non-proliferative), and the second most often diagnosis is fibroadenoma. Though fibrocystic mastosis is not clearly defined, it is still admitted that in order to support this diagnosis it is first compulsory to exclude malignant tumours. Only in 5% of the women with fibrocystic mastosis cellular changes can be revealed in the form of atypical hyperplasia, which are a risk factor for cancer. The lesion that delimits cancer from non-cancer is ductal carcinoma in situ. An incidence of over 20% is present in the countries that use mammographic screening

[Combination of busulfan with increased-dose of fludarabine as conditioning regimen for MDS and MDS-AML patients with allo-HSCT].

Science.gov (United States)

Yuan, Jing; Ren, Hanyun; Qiu, Zhixiang; Li, Yuan; Wang, Mangju; Liu, Wei; Xu, Weilin; Sun, Yuhua; Wang, Lihong; Liang, Zeyin; Dong, Yujun; Ou, Jinping; Wang, Wensheng; Yin, Yue; Cen, Xinan; Wang, Qian

2015-06-01

To investigate the safety and efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for myelodysplastic syndrome (MDS) and secondary acute myelogenous leukemia (MDS-AML) using conditioning regimen with busulfan (Bu) and increased-dose of fludarabine (ID-Flu). A total of 49 patients with MDS or MDS-AML were treated by allo-HSCT, the clinical data was analyzed retrospectively. All patients achieved hematopoietic reconstitution. Neutrophil engraftment was at 10 - 22 days (median 13 days), and platelet engraftment was at 8 - 66 days (median 16 days). The cumulative incidences of Ⅱ-Ⅳ degree acute graft-versus-host disease (GVHD), hemorrhagic cystitis (HC), and hepatic venous occlusive disease (VOD) were 28.6%, 14.3% and 2.0%, respectively. The transplant-related mortality (TRM) was only 4.1% at 100d and 8.2% at 1-92 months of followed-up (median 14 months) period. Overall survival (OS) and disease free survival (DFS) was 75.5%, 73.5%, respectively. Kaplan-Meier curve showed that 3-year OS and 3-year DFS was (71.1 ± 7.8)%, (66.7 ± 8.3)%, respectively, with a relapse incidence (RI) 16.3%. OS for MDS and MDS-AML was 81.5% and 68.2%, and RI in two settings was 3.7%, 31.8%, respectively. OS for MDS-AML at complete remission (CR) and non-CR subgroup was 83.3% and 50.0%, respectively, while cumulative RR was 16.7% and 50.0%, respectively. OS and RI except for non-CR subgroup were 82.1% and 7.7%. Univariate analysis showed that pre-HSCT disease status had correlation with OS (P=0.031), but age, decitabine in conditioning regimen, stem cell source, HLA matching, patient-donor gender, dose of mononuclear cells and GVHD had no correlation with OS. Bu/ID-Flu conditioning regimen for MDS and MDS-AML has high efficiency, fewer complications, lower toxicity and TRM. The OS and DFS were higher and RI was lower except for refractory MDS-AML patients. The regimen is valuable for clinical application.

Fluidní spalování suchého stabilizovaného čistírenského kalu z čistírny odpadních vod Brno - Modřice

Czech Academy of Sciences Publication Activity Database

Pohořelý, Michael; Durda, Tomáš; Moško, Jaroslav; Zach, Boleslav; Svoboda, Karel; Šyc, Michal; Beňo, Z.; Kameníková, Petra; Jeremiáš, Michal; Brynda, Jiří; Krausová, Aneta; Skoblia, S.; Hartman, Miloslav; Punčochář, Miroslav

2015-01-01

Roč. 7, č. 2 (2015), s. 36-41 ISSN 1804-2058 R&D Projects: GA TA ČR TE02000236 Institutional support: RVO:67985858 Keywords : fluidized bed * sewage sludge * incineration Subject RIV: CI - Industrial Chemistry, Chemical Engineering http://paliva.vscht.cz/cz/archiv-clanku/detail/27

Atypický vývoj cementářských slínovců ve velkolomu Úpohlavy a původ tuhých slínkových nodulí

Czech Academy of Sciences Publication Activity Database

Novák, Jiří Karel

2007-01-01

Roč. 36, - (2007), s. 4-5 ISSN 1802-2480 Institutional research plan: CEZ:AV0Z30130516 Keywords : siliceous marlstone * clinker * rigid nodules * grindability * Bohemian Cretaceous Basin * Úpohlavy Subject RIV: DB - Geology ; Mineralogy

Výsledky hydrobotanické exkurze pracovní skupiny pro studium makrofyt vod a mokřadů při ČBS na Mimoňsko (severní Čechy) v roce 2006

Czech Academy of Sciences Publication Activity Database

Černý, R.; Adamec, Lubomír

2008-01-01

Roč. 43, č. 2 (2008), s. 337-341 ISSN 1211-5258 Institutional research plan: CEZ:AV0Z60050516 Keywords : aquatic and wetland macrophytes * Mimoň region * Česká Lípa district Subject RIV: EF - Botanics

Temporal species turnover and plant community changes across different habitats in the Lake Engure Nature Park, Latvia

Directory of Open Access Journals (Sweden)

Rūsiņa Solvita

2014-04-01

Full Text Available Veģetācijas dinamikas izpētē reti ir gadījumi, kad monitoringu vienlaicīgi veic vairākās atšķirīgās ekosistēmās. Tomēr šāda veida pētījumi ļauj padziļināti izprast veģetācijas struktūras un pazīmju izmaiņu mehānismus. Šajā pētījumā aplūkotas lakstaugu stāva izmaiņas, sugu aprite un sugu skaita-laika attiecība dažādu biotopu griezumā 12 gadu periodā ILTER monitoringa stacijā Engures ezera dabas parkā. Sugu aprite laikā definēta kā atšķirība sugu sastāvā starp diviem laika periodiem. Sugu skaita-laika attiecība tika novērtēta, izmantojot slīdošo logu pieeju. Detrendētā korespondentanalīze izmantota, lai noskaidrotu ikgadējās izmaiņas sugu sastāvā. Sugu skaits un kumulatīvais skaits, kā arī daudzveidība izteiktāk mainījās sugām bagātākajos nemeža biotopos, bet mazāk - meža biotopos. Sugu aprite stipri atšķīrās starp biotopiem, un tā nebija saistīta ar biotopu stabilitāti, kā tas konstatēts citos līdzīgos pētījumos. Sugu skaita-laika attiecība sešos biotopos bija stipri zemāka, nekā minēts līdz šim publicētos pētījumos. Tas varētu būt skaidrojams ar kopējo platuma grādu sugu daudzveidības gradientu, jo līdzšinējie pētījumi veikti galvenokārt zemajos platuma grādos, bet šajā pētījumā apskatītie biotopi reprezentē boreālo zonu. Augstajos platuma grādos gan sugu daudzveidība, gan aprite ir zemāka nekā zemajos platuma grādos. Veģetācijas dinamika nabadzīgā zālājā skābā augsnē, starpkāpu ieplakā, zāļu purvā un kāpu mežā interpretējama kā fluktuācijas. Sausā un mitrā mežā un piejūras zālājā bija novērojamas veģetācijas virzītas izmaiņas jeb sukcesija (attiecīgi - kserofitizācija, sugu sastāva nomaiņa un aizaugšana. Pludmales veģetācijas izmaiņās konstatētas gan dabiskas sukcesijas pazīmes (veģetācijas saslēgšanās, gan antropogēni izraisītu fluktuāciju pazīmes.

El Reto de la IPTV, experiencia del Piloto en Cuba y perspectivas

Directory of Open Access Journals (Sweden)

Luís Enrique Conde del Oso

2010-09-01

Full Text Available Normal 0 21 false false false ES-TRAD X-NONE X-NONE MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Se aborda el impacto que podría tener la introducción en Cuba de los Servicios de IPTV emple-ando diferentes Tecnologías de Acceso de Banda Ancha que actualmente dispone ETECSA, la estructura organizacional requerida y los principales actores que aparecen en este tipo de negocio así como la estructura tecnológica a desplegar para la oferta de Broadcast TV y Video Bajo Demanda (VoD.  También se muestra una pequeña Plataforma de Servicios de IPTV construida con el objetivo de probar las Redes de Acceso de ETECSA permitiéndonos definir con mayor claridad que tipo de Plataforma de IPTV sería la más adecuada a introducir en función de las potencialidades de nuestras Redes de Acceso, facilitándonos adicionalmente la creación de servicios internos en ETECSA de Videoconferencia y Videovigilancia con un mínimo costo de las inversiones. Finalmente se hace referencia a los despliegues en el mundo de este novedoso y prometedor servicio y como podría aportar beneficios a la Sociedad Cubana a partir de un alcance masivo del mismo y con un enfoque a importantes esferas sociales en Cuba.

Pregnancy and recurrence rates in infertile patients operated for ovarian endometriosis.

Science.gov (United States)

Luţuc, Monica Holicov; Nemescu, D; Onofriescu, Alina; Târnovanu, Mihaela; Moscalu, Mihaela; Onofriescu, M

2015-01-01

The study deals with the preoperative ultrasound diagnosis of ovarian endometriosis, postoperative ultrasound reassessment, laparoscopic surgical resolution of ovarian endometriosis, estimation of recurrence risk 12 months after surgery by ultrasound, reappearance of clinical symptoms (such as pain) or second-look laparoscopy, and pregnancy rate 2 years after surgery. 140 patients with en- dometriosis and infertility admitted to the Iasi "Cuza-Vodă" Clinical Hospital of Obstetrics and Gynecology between the years 2009-2011 were included in the study. The patients were divided into 2 groups: group 1-59 cases that refused in vitro fertilization procedures, did not afford in vitro fertilization (IVF) or had minimal endometriosis and young ages and thus a possibility of delaying treatment, and group 2--62 cases which underwent IVF procedures immediately after surgery. No significant differences in the chance of becoming pregnant were found between the two groups (χ2 = 2.06, p = 0.0891, 95% CI); in group 1, 11.86% pregnancies were obtained while in group 2 the pregnancy rate was 11.29%. Based on the nonparametric method of analysis of contingency tables we could estimate the odds of becoming pregnant in the study groups, obtaining an odds ratio (OR = 1.16, CI: 1.04-2.23, 95% CI). This result indicated that in group 1 the odds of becoming pregnant was not significantly higher, and the estimation was made for a confidence interval of 95%. The study had in view the assessment of pregnancies obtained in the study groups and the time interval (number of weeks) from the time of intervention until the occurrence of pregnancy. The Kaplan-Meier analysis enabled the assessment of the mean value and the median value of the number of weeks until becoming pregnant, and these values did not show significant differences (χ2 = 1.55, p = 0.212, 95% CI). For endometriosis associated with infertility, hormonal suppression does not improve fertility, and therefore surgery followed by

Circulations in the Bay of Bengal and the Arabian Sea with Reference to Safe Disposal of Radioactive Wastes Near the Indian Coasts; Les Circulations dans les Eaux du Golfe du Bengale et de la Mer d'Oman et l'Elimination sans Danger des Dechets Radioactifs pres des Cotes Indiennes; 0426 0418 0420 0414 ; Circulaciones en el Golfo de Bengala e en el Mar Arabico con Relacion a la Evacuacion sin Riesgos de Desechos Radiactivos Frente al Litoral Indio

Energy Technology Data Exchange (ETDEWEB)

Rama Sastry, A. A. [Meteorological Office, Poona 5 (India)

1960-07-01

dannyh, sobrannyh razlichnymi jekspedicijami v Indijskom okeane, izuchaetsja fizicheskaja okeanografija v rajone k severu ot jekvatora. Kak v Bengal'skom zalive, tak i v Aravijskom more na glubine do 200 metrov imeetsja po krajnej mere tri razlichnyh vodnyh sloja. V vidu ochen' sil'noj rastvoritel'noj sposobnosti vod Bengal'skogo zaliva poverhnostnye vody mogut byt' podrazdeleny eshhe na neskol'ko kategorij. Po gorizontal'nomu raspredeleniju razlichnyh okeanograficheskih parametrov daetsja cirkuljacija vodnyh mass na razlichnyh urovnjah do 150 metrov vdol' indijskogo poberezh'ja ; jeto zhe otnositsja i k vodnym massam do 500 metrov po vertikal'nomu secheniju. Uroven' nepodvizhnyh vod, kak kazhetsja, nahoditsja vyshe 500 metrov i menjaetsja kak po ploshhadi, tak i po vremeni. Smeshenie vod vyvoditsja iz otnoshenija T-S (vremja-ploshhad'). Privodjatsja sezony povyshenija i ponizhenija urovnja vody vdol' poberezh'ja i rassmatrivaemogo rajona. Intensivnost' povyshenija urovnja vody vdol' poberezh'ja bolee vyrazhena i v techenie jetogo perioda proishodit polnoe smeshenie sloev vody na priberezhnoj otmeli. Glubokovodnye massy razdeljajutsja na vody jekvatorial'noj chasti Indijskogo okeana, antarkticheskie promezhutochnye sloi vody sovmestno s vodami Krasnogo morja i na neznachitel'nuju chast' vod central'noj chasti Indijskogo okeana, glubokovodnye massy Indijskogo okeana i antarkticheskie donnye vody. Daetsja raspredelenie jetih vodnyh mass, a takzhe cirkuljacija glubinnyh vodnyh sloev k severu ot jekvatora. Kak kazhetsja, za poslednie 60 let antarkticheskie donnye vody prodvigajutsja dalee k severu ot jekvatora kak v Bengal'skom zalive, tak i v Aravijskom more. V svjazi s jetim nabljudaetsja ponizhenie solenosti kak v Bengal'skom zalive, tak i v Aravijskom more. V zakljuchenie predlagetsja programma dal'nejshih okeanograficheskih issledovanij v svjazi s bezopasnym udaleniem radioaktivnyh othodov, v chastnosti v Aravijskoe more. (author)

Možnosti využití analýzy obrazu při vyhodnocování mikrobiální biomasy a aktivity ve vzorcích přirozených vod

Czech Academy of Sciences Publication Activity Database

Nedoma, Jiří; Vrba, Jaroslav; Štrojsová, Alena; Šimek, Karel; Znachor, Petr

2003-01-01

Roč. 10, č. 1 (2003), s. 59-61 ISSN 1336-300X. [Conference of Slovak Limnological Society and Czech Limnological Society /13./. Banská Štiavnica, 23.06.2003-27.06.2003] R&D Projects: GA ČR GA206/97/0072; GA ČR GA206/00/0063; GA AV ČR IAA6017202 Institutional research plan: CEZ:AV0Z6017912 Keywords : image analysis * microbial ecology Subject RIV: EE - Microbiology, Virology

Reálné možnosti reduktivní dehalogenace chlorovaných látek přítomných ve vodách pomocí elementárních kovů

Czech Academy of Sciences Publication Activity Database

Kaštánek, František; Čížek, Z.

2010, č. 3 (2010), s. 247-254 ISSN 1804-0195 R&D Projects: GA MPO FI-IM3/050 Institutional research plan: CEZ:AV0Z40720504 Keywords : reductive dehalogenation * grey cast iron * cast iron with palladium Subject RIV: CI - Industrial Chemistry, Chemical Engineering www.WasteForum.cz

Původ pojmu subjektivního práva v antickém právním myšlení v kontextu uvažování o lidských právech

Czech Academy of Sciences Publication Activity Database

Šejvl, Michal

2014-01-01

Roč. 153, č. 6 (2014), s. 448-463 ISSN 0231-6625 R&D Projects: GA ČR GA13-30299S Institutional support: RVO:68378122 Keywords : concept of rights * human rights * classical antiquity Subject RIV: AG - Legal Sciences

Znovu odkrytá nástěnná malba "Průvod a Klanění tří králů" v presbytáři kostela sv. Martina v Sedlčanech

Czech Academy of Sciences Publication Activity Database

Pavlíková, M.; Popová, T.; Všetečková, Zuzana

-, č. 23 (2016), s. 252-268 ISSN 1211-5169 R&D Projects: GA ČR GA13-39192S Institutional support: RVO:68378033 Keywords : Middle Ages (about 1400) * wall painting * iconography Subject RIV: AL - Art, Architecture, Cultural Heritage

[Cervugid ovules in cervico-vaginal infections and cervix uteri precancerous conditions treatment].

Science.gov (United States)

Zanoschi, Ch; Anton, C; Anton, E; Costăchescu, Gh; Teleman, S; Costăchescu, G; Ciupilan, I; Cărăuleanu, M; Cărăuleanu, A; Leica, V; Pânzaru, C; Grigore, M; Merticaru, I; Huianu, O; Huianu, L; Chifan, M

2004-01-01

This medicine was authorized by the National Drug Agency (ANM, Bucureşti) in 2001. To evaluate the effectiveness and the tolerance to Cervugid-ovules, a preparation that combines the polyvalent local antiinflammatory action of chloramphenicol, metronidazole and nystatin with the effect of hydrocortisone acetate, an unspecific anti-inflammatory agent; they all are embedded in a Lipex-403, semisynthetic fat. The evaluation of 500 patients ages between 15 and 85 years with genital infections, registered in the files of "Cl. II Obst. and Gynecology" of the Cuza-Vodă Hospital from Iaşi has been studied. We studied the subjective manifestations (local discomfort and pelvic pains, local burning and dryness,vulvovaginal itching and dyspareunia) and objective manifestations (vaginal and cervical secretion, the cytotest performed and colored though the Papanicolaou method and reported in the Bethesda system). Healing of the subjective symptoms in 98%, healing of the leukorrhea--as a main objective symptom--in 95%; The Bethesda system cytotest was one of the inflammatory type in the most of the cases and there wew found in 85 cases: 6 ASCUS, 41 LSIL, and 37 HSIL. The use of Cervugid had a healing response in most of the cases when used in acute and chronic cervico-vaginal inflammatory processes. Cervugid may be considered as an important agent in the treatment of the precancerous affections af the cervix uteri on the following reasons: zhe cure of the infections caused by chlamydia, involved in the etiology of cervical neoplasms, the cure of the HPV infection under episome form, classified in the Bethesda system within the ASCUS, AGUS or LSIL classes. When the cytotest was in the HSIL class, a conization in the LLETZ method was performed. Cervugid is conceived for those three main categories of pathogenic factors related to the etiology of cervico-vaginitis: microbia germs, protozoa and mycosis. In addition, it is active on chlamydia and mycoplasms, always sensitive to

Análisis del mensaje publicitario sobre la audiencia segmentada de la IPTV Analysis of the advertising message on the segmented audience of IPTV

Directory of Open Access Journals (Sweden)

Enrique Carrasco Molina

2011-04-01

Full Text Available Este artículo se centra en el análisis de algunas de las innovadoras alternativas que ofrece Internet, en simbiosis con la ‘televisión a la carta’, como la IPTV. Se estudia el nuevo sistema como atractiva plataforma publicitaria para anunciantes, y cómo éstos se benefician de la nueva y determinante segmentación de las audiencias. Se traza una panorámica sobre la importante penetración que ha tenido Internet en la propia vida de las personas, condicionando su acercamiento a cualquier fenómeno comunicativo. Se efectúa un trabajo de campo mediante la descripción y la cuantificación de alternativas que registran los mejores resultados en el aspecto publicitario dentro del mismo formato IPTV. Se estudian dos de los sistemas de IPTV que hoy día funcionan en España (Imagenio, Yatv, y se analizan metodologías del discurso publicitario que aprovechan el recurso de la cercanía para mejorar sus posibilidades de impacto, impulsando el consumo de un producto concreto. Se exploran, asimismo, los nuevos diseños del mensaje publicitario que rompen con el concepto de spot tradicional asociado, sobre todo, a las cadenas de televisión generalista.This article focuses on the analysis of some of the innovative ways the Internet offers, in symbiosis with the VOD (video on demand, TV systems which allow users to select and watch/listen to video or audio content on demand, such as IPTV. The new system is studied as an attractive advertising platform for advertisers, and how they benefit from the new and crucial segment of the audience. It draws a panoramic view of the important insight that has had Internet in the lives of individuals, determining their approach to any communicative phenomenon. The article describes and quantifies the best alternatives to implement results in the advertising aspect within the IPTV format. We study two IPTV systems that operate in Spain today (Imagenio, YATV and advertising discourse analysis methodologies that

The Radioisotopic Determination of Diffusion Coefficients and Currents in Natural Waters. Surface Collection of Radioactive Fall-Out on a Large Alpine Lake; Determination par detection nucleaire des coefficients de diffusion et des courants dans les eaux naturelles. Evolution de la surface de collection d'un grand lac alpin pour les retombees radioactives; Opredelenie koehffitsienta diffuzii i skorosti techeniya estestvennykh vod pri pomoshchi yadernogo detektirovaniya. Ehvolyutsiya poverkhnosti sbora radioaktivnykh osadkov na bol'shom al'pijskom ozere; Determinacion por deteccion nuclear de los coeficientes de difusion y de las corrientes en las aguas naturales evolucion de la superficie de captacion de un gran lago alpino para las precipitaciones radiactivas

Energy Technology Data Exchange (ETDEWEB)

Chesselet, R.; Nordemann, D. [Service d' Electronique Physique, Centre d' Etudes Nucleaires de Saclay (France); Dussart, B. [Centre de Recherches Hydrobiologiques, CNRS, Gif-sur-Yvette (France)

1963-08-15

radioaktivnykh produktov v usloviyakh diffuzii i vstrechnykh potokov. Ispol'zovanie diffuzii radioaktivnykh produktov v ochen' nebol'shikh kolichestvakh i razlichnye metody obnaruzheniya pri pomoshchi yadernykh izmerenij vysokoj chuvstvitel'nosti mogut privesti v nastoyashchee vremya k nailuchshemu ponimaniyu diffuzii Tin situ'' i dvizheniyu mass prirodnykh vod. (author)

Movement of Radioactive Effluents in Natural Waters at Hanford; Le Mouvement des Effluents Radioactifs dans les Eaux Naturelles a Hanford; 0414 0412 0418 0416 0414 ; Movimiento de los Efluentes Radiactivos en Aguas Naturales en Hanford

Energy Technology Data Exchange (ETDEWEB)

Honstead, J. F.; Foster, R. F.; Bierschenk, W. H. [Hanford Laboratories Operation, Hanford Atomic Products Operation, General Electric Company, Richland, WA (United States)

1960-07-01

porod, prezhde chem dostignut podzemnyh vod. Bol'shinstvo radioaktivnyh materialov zaderzhivaetsja putem pogloshhenija ili drugih reakcij pri prohozhdenii cherez pochvu. Ochishhennaja takim obrazom voda i neznachitel'nye othody, dostigajushhie podzemnyh vod, napravljajutsja vmeste s nimi k reke Kolumbii. Skorost' i napravlenie opredeljajutsja formoj vodnogo gorizonta i gidravlicheskimi harakteristikami vodonosnyh plastov. Bol'shie ob{sup e}my vody, slivaemye v grunt, okazali korjonnoe izmenenie na harakter gorizonta podzemnyh vod. Ishodja iz izmerennoj pronicaemosti vodonosnyh plastov, srednee vremja prohozhdenija vody ocenivaetsja v 180 let. Priznaetsja takzhe to, chto maksimal'naja skorost' mozhet znachitel'no prevyshat' srednjuju velichinu. Odnako, vlijanie pogloshhenija ili drugih reakcij ochen' sil'no zamedljajut dvizhenie rastvorennogo materiala po otnosheniju k skorosti dvizhenija vody. Ne bylo obnaruzheno proniknovenija produktov delenija iz rajonov udalenija v rechnuju vodu. (author)

Vliv vegetačního krytu na disipaci energie a vodní režim v krajině - dopady na interakce biotických a abiotických složek v povrchových vodách

Czech Academy of Sciences Publication Activity Database

Pechar, Libor; Pokorný, Jan; Procházka, J.; Wotavová, K.; Pecharová, E.; Švehla, J.

2004-01-01

Roč. 3, č. 21 (2004), s. 249-255 ISSN 1212-0731. [Agroregion 2004. České Budějovice, 06.09.2004-07.09.2004] Institutional research plan: CEZ:AV0Z6087904 Keywords : Landscape function * water cycle * remote sensing Subject RIV: DO - Wilderness Conservation

Pasohlávky (K. Ú. Pasohlávky, K. Ú. Mušov, okr. Břeclav) „Za Tuchnou, U vodárny“. ÚK, VS, SMK. Sídliště, hroby. Záchranný výzkum

Czech Academy of Sciences Publication Activity Database

Komoróczy, Balázs; Klanicová, Soňa; Sázelová, S.; Vlach, Marek

2010-01-01

Roč. 2010, č. 51 (2010), s. 348-356 ISSN 1211-7250 R&D Projects: GA ČR GA404/09/1054 Institutional research plan: CEZ:AV0Z80010507 Keywords : Pasohlávky * Bronze Age * settlement * burial * rescue excavation Subject RIV: AC - Archeology, Anthropology, Ethnology

Prevence vzniku závažných havárií v DIAMO státní podnik, odštěpný závod Těžba a úprava uranu Stráž pod Ralskem

OpenAIRE

ŠIMÁČKOVÁ, Eva

2015-01-01

This bachelor thesis focuses on the area of precaution of serious emergency inception in buildings or facilities in DIAMO state-owned enterprise, fraction plant Extraction and Uranium Processing (Těžba a úprava uranu, further o. z. TÚU). This work elaborates the means of securing elementary tenets and principles in the area of precaution of serious emergency inception. The introductory part of the bachelor thesis emphasizes the need of solving the precaution of serious emergency inception are...

Optical Access Networks

Science.gov (United States)

Zheng, Jun; Ansari, Nirwan

2005-06-01

Call for Papers: Optical Access Networks With the wide deployment of fiber-optic technology over the past two decades, we have witnessed a tremendous growth of bandwidth capacity in the backbone networks of today's telecommunications infrastructure. However, access networks, which cover the "last-mile" areas and serve numerous residential and small business users, have not been scaled up commensurately. The local subscriber lines for telephone and cable television are still using twisted pairs and coaxial cables. Most residential connections to the Internet are still through dial-up modems operating at a low speed on twisted pairs. As the demand for access bandwidth increases with emerging high-bandwidth applications, such as distance learning, high-definition television (HDTV), and video on demand (VoD), the last-mile access networks have become a bandwidth bottleneck in today's telecommunications infrastructure. To ease this bottleneck, it is imperative to provide sufficient bandwidth capacity in the access networks to open the bottleneck and thus present more opportunities for the provisioning of multiservices. Optical access solutions promise huge bandwidth to service providers and low-cost high-bandwidth services to end users and are therefore widely considered the technology of choice for next-generation access networks. To realize the vision of optical access networks, however, many key issues still need to be addressed, such as network architectures, signaling protocols, and implementation standards. The major challenges lie in the fact that an optical solution must be not only robust, scalable, and flexible, but also implemented at a low cost comparable to that of existing access solutions in order to increase the economic viability of many potential high-bandwidth applications. In recent years, optical access networks have been receiving tremendous attention from both academia and industry. A large number of research activities have been carried out or

Pasohlávky (K.Ú. Pasohlávky, K.Ú. Mušov, okr. Břeclav) „U Vodárny, Za Tuchnou“. Mladý/pozdní eneolit, KZP. Záchranný výzkum. Hroby, sídlištní objekt

Czech Academy of Sciences Publication Activity Database

Komoróczy, Balázs; Klanicová, Soňa; Šebela, Lubomír; Vlach, Marek

2010-01-01

Roč. 2010, č. 51 (2010), s. 333-337 ISSN 1211-7250 R&D Projects: GA ČR GA404/09/1054 Institutional research plan: CEZ:AV0Z80010507 Keywords : Pasohlávky * eneolithic * burial * settlement Subject RIV: AC - Archeology, Anthropology, Ethnology

Web-based networking within the framework of ANENT

International Nuclear Information System (INIS)

Han, K.W.; Lee, E.J.; Kim, Y.T.; Nam, Y.M.

2004-01-01

will be loaded onto the website in the form of a database. Also, other input from different group activities will be provided on the website. Other efforts being made by KAERI are the coordination for the establishment of a Korean network of nuclear education and training, and a cyber education system. The Korean network will facilitate a national level integration of nuclear education and training institutions and their systematic link with a regional level network, i.e. ANENT. Concerning the cyber education and training system, materials in the form of multimedia text and VOD (video on demand) are being produced and loaded onto the KAERI website, which is linked with the ANENT website. This paper will discuss the details of the progress and major outcomes of the web-based exchange activity, in particular in terms of the ANENT web design, information collection, and cyber education and training

Možné způsoby narušení vodárenské soustavy a návrh opatření k zabránění jejího zneužití v Jihočeském kraji.

OpenAIRE

SOUKUPOVÁ, Eva

2014-01-01

The theoretical part of the thesis focuses on the characteristics of water as the basic structural element of the life on the Earth. It also mentions regulations related to critical infrastructure, water protection and water management. It describes water management system of the Czech Republic and the South Bohemian Region. It similarly characterizes the most probable chemical, biological or radiological water contaminants that might be abused by a man in the case of trespassing into waterwo...

The Decontamination of Low-Level Radioactive Waste Water at Risoe Research Establishment; Decontamination des Eaux Residuaires de Faible Radioactivite au Centre de Recherche de Risoe; 0414 0415 0417 0410 ; La Descontaminacion de Aguas que Reciben Desechos Radiactivos de Baja Actividad, en el Centro de Investigaciones de Risoe

Energy Technology Data Exchange (ETDEWEB)

Larsen, Ib [Research Establishment Risoe, Danish Atomic Energy Commission (Denmark)

1960-07-01

metros del punto de descarga, sea inferior a una decima parte del valor tolerado para el agua potable. Esto corresponde a 1 milicurie por mes contenido en 5000 metros cubicos de efluente. La memoria describira el sistema de control y el colector de efluentes del laboratorio, asi como la instalacion de descontaminacion y el edificio destinado al almacenaje de los residuos. Tambien expondra experiencias en curso sobre el factor de descontaminacion y sus aspectos economicos. (author) [Russian] V svjazi s medlennym obnovleniem vody v priemnike Roskil'de fiorda v nauchno-issledovatel'skom centre rizo postroena jeffektivnaja dezaktivacion- naja ustanovka, v kotoruju vhodit isparitel'. Predusmatrivaetsja, chto aktivnost' vody fiorda na rasstojanii 10 metrov ot tochki sbrosa dolzhna byt' men'she 0.1 aktivnosti, dopuskaemoj dlja pit'evoj vody. Jeto budet sootvetstvovat' 1 millikjuri v mesjac, soderzhashhihsja v 5,000 kub. metrov ishodjashhego potoka vody. Budet dano opisanie kontrolja i sbora laboratornyh stochnyh vod, dezaktivirujushhej ustanovki i sooruzhenija dlja hranenija ostatkov. Budet predstavlen rabochij opyt dezaktivacii i jekonomiki. (author)

Levels of Tritium in a Variety of New Zealand Waters and Some Tentative Conclusions from these Results; Concentration du tritium dans diverses eaux de Nouvelle-Zelande et conclusions provioires tirees des resultats obtenus; Urovni tritiya v razlichnykh vodakh novoj Zelandii i predvaritel'noe zaklyuchenie po etim rezul'tatam; Concentraciones de tritio en diferentes aguas de Nueva Zelandia y conclusiones provisionales basadas en los resultados obtenidos

Energy Technology Data Exchange (ETDEWEB)

Bainbridge, A E; O' Brien, B J [Institute of Nuclear Sciences, Gracefield (New Zealand)

1962-01-15

grifo en el Instituto de Ciencias Nucleares, a fin de calcular el tiempo de permanencia de las aguas en el deposito artesiano del Valle de Hutt. Se expone un numero limitado de resultados de las mediciones de tritio en nieves alpinas y en aguas de pozo geotermicas, aguas oceanicas y aguas de lluvia caidas sobre Wellington. (author) [Russian] Bol'shoe kolichestvo razlichnykh prob prirodnykh vod bylo otobrano dlya izucheniya s tsel'yu opredelit' izbytok tritiya. Seriya izmerenij tritiya v vodakh Akataravy bliz Vellingtona s aprelya 1956 po dekabr' 1960 goda pokazali nalichie v dozhdevykh vodakh, vypadayushchikh v Novoj Zelandii, tritiya, voznikshego v rezul'tate ispytaniya atomnykh bomb. Sravnenie ehtogo urovnya soderzhaniya tritiya s izmereniyami, proizvedennymi s vodoprovodnoj vodoj v Institute yadernykh issledovanij, bylo ispol'zovano dlya opredeleniya vremeni khraneniya vody v artezianskom bassejne KHut-Vallej. Budet predstavleno nekotoroe chislo rezul'tatov izmerenij tritiya v podzemnykh vodakh, v okeane, v dozhdevykh vodakh Vellingtona i v al'pijskikh snegakh. (author)

Zápis šesti až osmiletých dětí do kurzů sjezdového lyžování ve Slovinsku Enrolling 6–8 year old children in alpine skiing courses in Slovenia

Directory of Open Access Journals (Sweden)

Nina Makuc

2010-09-01

Full Text Available VÝCHODISKA: Lyžování je sportovní aktivitou, kterou většina dětí ráda praktikuje, a proto se rády zapisují do různých kurzů organizovaných lyžařskými školami, společnostmi a kluby. CÍL: Studie měla za cíl analyzovat důvody rodičů a zájmy spojené se zápisem jejich dětí do kurzů sjezdového lyžování a stanovit, jak vzdělání rodičů a jejich měsíční příjem ovlivňují četnost, s jakou jejich děti navštěvují lyžařské kurzy. METODY: Provedli jsme průzkum mezi 250 rodiči dětí ve věku 6–8 let, a to za použití dotazníku se 17 proměnnými. Byly vypočítány frekvenční a kontingentační tabulky. Statistická váha vztahů mezi proměnnými byla ověřena kontingentačním koeficientem. VÝSLEDKY: Výsledky ukázaly, že polovina rodičů alespoň jednou zapsala své dítě do kurzu sjezdového lyžování. Rodiče s vyšším vzděláním a vyšším měsíčním příjmem zapisují své děti do kurzů sjezdového lyžování častěji. Osoba, která v rámci rodiny navrhuje, aby se dítě zapsalo do takového kurzu, je většinou otec. Ve více než polovině rodin oba rodiče lyžují; ovšem tři čtvrtiny rodin spolu nikdy nechodí lyžovat nebo toto praktikují jen zřídka. Otcové hodnotí své lyžařské dovednosti lépe než matky. Důvod nejčastěji uváděný v souvislosti s tím, proč dané dítě nebylo zapsáno do kurzu sjezdového lyžování, byly finanční obtíže. Důvody rodičů pro to, aby se jejich děti naučily lyžovat, byly tyto: více než polovina rodičů si myslí, že by se jejich děti měly naučit dobře lyžovat, a 30 % rodičů přisuzuje velkou důležitost bezpečnosti na lyžařských svazích. Pouze 5 % rodičů by chtělo, aby se jejich dítě účastnilo lyžařských závodů. ZÁVĚRY: Naše zjištění pomohou organizátorům lyžařských kurzů l

Optical Access Networks

Science.gov (United States)

Zheng, Jun; Ansari, Nirwan

2005-01-01

Call for Papers: Optical Access Networks Guest Editors Jun Zheng, University of Ottawa Nirwan Ansari, New Jersey Institute of Technology Submission Deadline: 1 June 2005 Background With the wide deployment of fiber-optic technology over the past two decades, we have witnessed a tremendous growth of bandwidth capacity in the backbone networks of today's telecommunications infrastructure. However, access networks, which cover the "last-mile" areas and serve numerous residential and small business users, have not been scaled up commensurately. The local subscriber lines for telephone and cable television are still using twisted pairs and coaxial cables. Most residential connections to the Internet are still through dial-up modems operating at a low speed on twisted pairs. As the demand for access bandwidth increases with emerging high-bandwidth applications, such as distance learning, high-definition television (HDTV), and video on demand (VoD), the last-mile access networks have become a bandwidth bottleneck in today's telecommunications infrastructure. To ease this bottleneck, it is imperative to provide sufficient bandwidth capacity in the access networks to open the bottleneck and thus present more opportunities for the provisioning of multiservices. Optical access solutions promise huge bandwidth to service providers and low-cost high-bandwidth services to end users and are therefore widely considered the technology of choice for next-generation access networks. To realize the vision of optical access networks, however, many key issues still need to be addressed, such as network architectures, signaling protocols, and implementation standards. The major challenges lie in the fact that an optical solution must be not only robust, scalable, and flexible, but also implemented at a low cost comparable to that of existing access solutions in order to increase the economic viability of many potential high-bandwidth applications. In recent years, optical access networks

Sokolský exil jako přirozený důsledek podstaty sokolství [Sokol exile as a real consequence of the Sokol essence

Directory of Open Access Journals (Sweden)

Bohuslav Hodaň

2008-03-01

Full Text Available Letošní rok je jubilejním devadesátým rokem založení Československé republiky. Je to doba, kdy je vhodné vzpomenout událostí, které jsou historicky významné. Patří mezi ně i exilové hnutí, které je spojeno s několika etapami tohoto vývoje. Významnou součástí exilového hnutí byl i sokolský exil, do kterého se zapojilo velké množství členů Sokola. Nebyla to náhoda, ale logické vyústění sokolské "ideologie", logické vyústění filozofie, na jejímž základě sokolská organizace díky Tyršovi vznikla. Práce se vrací k jednotlivým etapám sokolského exilu a ukazuje vzájemnou propojenost sokolství – vlastenectví – brannost – exil. Zdůvodňuje také, proč se zabývá pouze obdobím do roku 1950. [The year 2008 is the year of the ninetieth anniversary of birth of the Czech-Slovak Republic. Since then, our state passed a very complicated and difficult development. In reaction on political events, many individuals, organizations and various movements participated on the birth and development of this state. One of these very important phenomena was the Czech-Slovak exile movement and its representative part, the exile of Sokol. In this movement, thousands of Sokol members participated. The connection of Sokol and the exile was not caused by chance or was not a result of an "ad hoc" solved situation. In all periods it was a logical consequence of content and realization of thoughts of the system, which the Sokol was bearer of. The exile activities, aversion against any non-democratic, anti-humanistic or even totalitarian tendencies were simply automatic and self-evident consequences of the Sokol "ideology" witnessed numerous changes of the political setting and underwent some changes in its own development. So, the ideology and the corresponding education were the basic presumptions of Sokol exile, manifested in the political, humanitarian as well as military sphere. The Sokol exile is not an

Value-informed space systems design and acquisition

Science.gov (United States)

Brathwaite, Joy

-centric approach are identified and discussed. In addition, an innovative approach for characterizing value uncertainty through partial moments, a technique used in finance, is adapted to an engineering context and applied to priced space systems. Partial moments disaggregate uncertainty into upside potential and downside risk, and as such, they provide the decision-maker with additional insights for value-uncertainty management in design and acquisition. For unpriced space systems, this research first posits that their value derives from, and can be assessed through, the value of information they provide. To this effect, a Bayesian framework is created to assess system value in which the system is viewed as an information provider and the stakeholder an information recipient. Information has value to stakeholders as it changes their rational beliefs enabling them to yield higher expected pay-offs. Based on this marginal increase in expected pay-offs, a new metric, Value-of-Design (VoD), is introduced to quantify the unpriced system’s value. The Bayesian framework is applied to the case of an Earth Science satellite that provides hurricane information to oil rig operators using nested Monte Carlo modeling and simulation. Probability models of stakeholders’ beliefs, and economic models of pay-offs are developed and integrated with a spacecraft payload generation tool. The case study investigates the information value generated by each payload, with results pointing to clusters of payload instruments that yielded higher information value, and minimum information thresholds below which it is difficult to justify the acquisition of the system. In addition, an analytical decision tool, probabilistic Pareto fronts, is developed in the Cost-VoD trade space to provide the decision-maker with additional insights into the coupling of a system's probable value generation and its associated cost risk.

Biological Aspects of Disposal of Radioactive Wastes in Marine Environments; Aspects Biologiques de l'Elimination des Dechets Radioactifs dans le Milieu Marin; 0411 0418 041e 041b 041e 0413 0418 0427 0414 ; Aspectos Biologicos de la Evacuacion de Desechos Radiactivos en Medios Marinos

Energy Technology Data Exchange (ETDEWEB)

Chipman, Walter A. [United States Bureau of Commercial Fisheries (United States)

1960-07-01

issledovanijam poluchajutsja svedenija, ves'ma vazhnye dlja ustanovlenija metodov udalenija othodov i dlja obespechenija bezopasnosti plavanija rabotajushhih na atomnoj jenergii sudov v pribrezhnyh vodah. Jeti dannye polezny takzhe dlja razvitija programm sistematicheskogo otbora prob, cel' kotoryh zakljuchaetsja v obnaruzhenii i ocenke riska ot sluchajnogo zagrjaznenija pribrezhnyh vod. (author)

Autonomic nervous system activity during acclimatization after rapid air travel across time zones: A case study [Aktivita autonomního nervového systému během aklimatizace po rychlém přeletu časových pásem: Kazuistika

Directory of Open Access Journals (Sweden)

Michal Botek

2009-06-01

řelet přes poledníky (jeden východním směrem +6 hodin, druhý západním směrem –7 hodin byly metodou SA HRV monitorovány změny v aktivitě ANS a byl posuzován průběh aklimatizace. VÝSLEDKY: První sportovec, který absolvoval let z Prahy do Pekingu (Čína, mohl začít s intenzivním tréninkem již čtvrtý den po příletu. V druhé případové studii (sportovkyně nebyl bezprostředně po přeletu z Prahy do Bogoty (Kolumbie pozorován žádný aktuální pokles aktivity ANS. K úpravě tréninkového zatížení bylo u této sportovkyně nutné přistoupit až třetí den pobytu. ZÁVĚRY: Práce potvrdila, že reakce organismu na rychlý přesun přes poledníky je založená na změnách aktivity ANS a je individuálně variabilní. Proto se u vrcholových sportovců může v budoucnu stát metoda SA HRV vodítkem při řešení otázky aklimatizační strategie a optimalizace sportovní výkonnosti.

Return to play after health complications associated with infectious mononucleosis guided on autonomic nervous system activity in elite athlete: A case study [Rekonvalescence po infekční mononukleóze řízená na základě aktivity autonomního nervového systému u vrcholového sportovce: Kazuistika

Directory of Open Access Journals (Sweden)

Jaroslav Větvička

2012-06-01

šlo ke kulminaci ranní únavy. Mezi komplexními indexy SA HRV a pocitem ranní únavy nebyl prokázán žádný vztah. ZÁVĚRY: Rekonvalescence řízená na základě monitoringu aktivity ANS přispěla ke zlepšení kondice, přestože aktivita jaterních enzymů zůstávala hraniční až mírně zvýšená. Dávkování zatížení založené na subjektivním hodnocení únavy v rámci rekonvalescence po InM bude pravděpodobně nepřesné. Proto se domníváme, že neinvazivní metoda SA VSF společně s pravidelnou biochemickou analýzou jaterních enzymů se zdá být slibnou strategií pro stanovení bezpečného zatížení během rekonvalescence po InM, která povede k návratu sportovce do plného zatížení.

Present attitudes of physical education students towards future employment in their profession [Současné názory studentů tělesné výchovy na jejich budoucí zaměstnání v této profesi

Directory of Open Access Journals (Sweden)

Magdalena Majer

2010-06-01

Full Text Available OBJECTIVE: The aim of the research was to examine empirically the attitudes of physical education students towards their future profession in physical culture and some of their considerations about the choice of their field of study and their opinion about the course of studies. METHODS: The research embraced physical education students studying at the Academy of Physical Education in Cracow. The research took place in two stages (May 2005 and 2008. The first part involved first year students (N = 162, the second the same students then being fourth year students, but only those, who passed all semesters on time (N = 103. The students' attitudes towards their future profession were examined by means of a questionnaire worked out by Grabowski and Skrzypiec. RESULTS: For 45.6% of our respondents the choice of their field of study and prospective profession was determined by positive factors. More than half of the tested students (51.6% chose physical education as their field of study because of their interests and passion. Salary, stability and terms of work are also significant factors. More than half of the respondents declare their willingness to work in their profession after graduation. CONCLUSIONS: From among the values preferred while choosing the physical educator's profession, passion was the main choice of the respondents, regardless of gender. The fact that their studies' positive influence on the respondents' attitudes towards their future profession decrease clearly between the first and the last year of studies, is alarming. It would be advisable to do more detailed research in other schools to verify the educational system and the practical preparation of prospective physical education teachers.[CÍLE: Cílem výzkumu bylo empiricky posoudit názory studentů tělesné výchovy na jejich budoucí zaměstnání v tělesné výchově a některé z důvodů, proč si vybrali tento studijní obor, a jejich názory na průběh studia

Slavic *tъrgъ, Old Church Slavonic trъgъ. Their origin and distribution in postclassical times

Directory of Open Access Journals (Sweden)

Sorin Paliga

2015-09-01

łowiańskich. Ma wiele derywatów zarówno wśród nazw apelatywnych, jak i nazw własnych, by wymienić choćby bułg. Tărgovište (także ważne stanowisko archeologiczne, rum. Târgoviște, zapisywane także jako Tîrgoviște (przez pewien czas polityczne centrum Muntenii, ok. 80 km na północny zachód od Bukaresztu czy fin. Turku (gen. Turun, czy też dyskusje na temat pochodzenia polskiej nazwy Toruń. Pochodzenie targu było wielokrotnie przedmiotem dyskusji, jednak nazwy nie można analizować niezależnie od starożytnej nazwy iliryjskiego miasta Tergitio, późniejsze Tergeste, poprzednik współczesnego słoweńskiego Trst i włoskiego Trieste. Václav Machek rozpatrywał nawet tak archaiczne pochodzenie jak sumeryjskie, przywołując asyryjsko-babilońskie tamgaru ‘handlowiec’, idąc za sugestią orientalisty Bedřicha Hrozného, który odczytał pismo hetyckie (1915. Autor ten  stwierdza, że pochodzenie rozpatrywanego słowa trzeba uznać za bałkańskie lub raczej wspólne iliryjsko-trackie jako termin techniczny związany z handlem. Jego rozpowszechnienie z południa na północ jest całkowicie zrozumiałe, jeśli wziąć pod uwagę północny zasięg stosunków ekonomicznych Imperium Rzymskiego, a później Bizancjum, w czasach trudnych do sprecyzowania, jednak zdecydowanie wcześniejszych od słowiańskiej ekspansji, tj. sprzed VI w. n. e. Pochodzenie orientalne jest mało prawdopodobne. Jeżeli jednak brać je pod uwagę, to należy przyjąć, że wcześniej słowo to pojawiło się w klasycznej grece, a następnie, w dość wczesnym okresie, z niej rozpowszechniło się w kierunku północnym. Bardziej prawdopodobne wydaje się pochodzenie śródziemnomorskie, a być może nawet przedindoeuropejskie, według Macheka praevropský původ.

A Review of Radioactive Waste Disposal to the Ground at Hanford; Etude sur l'Elimination dans le Sol des Dechets Radioactifs a Hanford; 041e 0411 0417 0414 ; Evacuacion de Desechos Radiactivos en el Subsuelo de Hanford

Energy Technology Data Exchange (ETDEWEB)

Pearce, D. W.; Lindbroth, C. E.; Nelson, J. L.; Ames, Jr., L. L. [Hanford Laboratories, Hanford Atomic Products Operation, General Electric Company, Richland WA (United States)

1960-07-01

secciones transversales geologicas, que muestran el volumen de las aguas freaticas y la superficie del terreno contaminados. (author) [Russian] Dajutsja vyvody po udaleniju radioaktivnyh othodov v zemlju s hjenfordskih zavodov po razdeleniju izotopov. Opisyvaetsja udalenie vysokoaktivnyh othodov v bolota, rvy i vyrabotki. Daetsja obzor literatury po izucheniju ionnogo obmena pochvy v rajone Hjenforda. Daetsja opisanie jeksperimenta v polevyh uslovijah s model'ju vyrabotki; predvaritel'nye rezul'taty pokazyvajut, chto rassredotochenie othodov pod ustanovkoj dlja ih udalenija mozhet predstavljat' bol'shuju vygodu, chem ranee predpolagalos'. Takzhe soobshhaetsja o reakcii kal'cit-fosfata. Vazhnymi peremennymi velichinami, vlijajushhimi na udalenie Sr{sup +2} javljajutsja vneshnjaja poverhnost' kal'cita, pH slivaemyh othodov, skorost' potoka, temperatura i soderzhanie ionov v fosfate. Radioizotopy, kotorye mogut nakaplivat'sja v kostjah, takzhe udaljajutsja iz F- rastvorov, kogda imeetsja kontakt s kal'citom. Ceolit klinoptilolit pokazyvaet vysokuju izbiratel'nost' dlja Cs{sup +} dazhe v prisutstvii povyshennoj koncentracii Na{sup +}. Vlijanie udalenija othodov v zemlju v krupnyh masshtabah v Hjenforde pojasnjaetsja s pomoshh'ju karty i teologicheskih razrezov, pokazyvajushhih razmery zagrjaznenija zemli i gruntovyh vod. (author)

Examination of the Excavation Damaged Zone in the TASS tunnel, Aespoe HRL

Energy Technology Data Exchange (ETDEWEB)

Olsson, Mats (Swebrec, Luleaa Univ. of Technology, Luleaa (Sweden)); Markstroem, Ingemar; Pettersson, Anders; Straeng, Malin (Golder Associates, Uppsala (Sweden))

2009-10-15

The question of an existing continuous Excavation Damage Zone (EDZ) is very important for SKB. Is it possible to use drilling and blasting in the planned repository for spent nuclear fuel? Could fractures from blasting form a continuous EDZ? In order to increase the understanding of the EDZ and the possibility of an existing continuous EDZ along the deposition tunnel, SKB decided to examine the fracturing in a selected area of the TASS tunnel and to create a 3D model of the fractures in the investigated area. It was of special interest to study the transition zones between the blast rounds to examine if the EDZ from the bottom charges could form a continuous EDZ from one round to another. The TASS-tunnel is situated at the 450-m level in the Aespoe Hard Rock Laboratory. The tunnel, with a cross-section area of 20 m2, was planned to be 90 m long. In a subproject called Excavation the purpose was to test different plans for drilling, charging and initiation in order to give recommendations on how the final repository of spent fuel should be excavated. The test methodology used in this investigation comprised the following steps: selecting test area, drilling and wire sawing of blocks, surveying the blocks, removal and transportation of the blocks to the surface, cutting the blocks into slabs, fracture identification with penetrants, positioning and photographing the slabs, digitizing and 3D modelling of the fractures. The test area for EDZ consisted of an 8 m long and 1.5 m high section in excavation sequence no 4. The selected section covered the end of round 9, the entire round 10 and the start of round 11. In the contour and the helpers small diameter charges for smooth blasting were used (decoupled charges). These charges also have a relatively low detonation velocity (VOD) and this, together with the decoupling, gives short fracture lengths i.e. a small EDZ. The contour holes and the helpers were initiated with electronic detonators to achieve a simultaneous

Examination of the Excavation Damaged Zone in the TASS tunnel, Aespoe HRL

International Nuclear Information System (INIS)

Olsson, Mats; Markstroem, Ingemar; Pettersson, Anders; Straeng, Malin

2009-10-01

The question of an existing continuous Excavation Damage Zone (EDZ) is very important for SKB. Is it possible to use drilling and blasting in the planned repository for spent nuclear fuel? Could fractures from blasting form a continuous EDZ? In order to increase the understanding of the EDZ and the possibility of an existing continuous EDZ along the deposition tunnel, SKB decided to examine the fracturing in a selected area of the TASS tunnel and to create a 3D model of the fractures in the investigated area. It was of special interest to study the transition zones between the blast rounds to examine if the EDZ from the bottom charges could form a continuous EDZ from one round to another. The TASS-tunnel is situated at the 450-m level in the Aespoe Hard Rock Laboratory. The tunnel, with a cross-section area of 20 m 2 , was planned to be 90 m long. In a subproject called Excavation the purpose was to test different plans for drilling, charging and initiation in order to give recommendations on how the final repository of spent fuel should be excavated. The test methodology used in this investigation comprised the following steps: selecting test area, drilling and wire sawing of blocks, surveying the blocks, removal and transportation of the blocks to the surface, cutting the blocks into slabs, fracture identification with penetrants, positioning and photographing the slabs, digitizing and 3D modelling of the fractures. The test area for EDZ consisted of an 8 m long and 1.5 m high section in excavation sequence no 4. The selected section covered the end of round 9, the entire round 10 and the start of round 11. In the contour and the helpers small diameter charges for smooth blasting were used (decoupled charges). These charges also have a relatively low detonation velocity (VOD) and this, together with the decoupling, gives short fracture lengths i.e. a small EDZ. The contour holes and the helpers were initiated with electronic detonators to achieve a simultaneous

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support

Science.gov (United States)

Estcourt, Lise J; Malouf, Reem; Trivella, Marialena; Fergusson, Dean A; Hopewell, Sally; Murphy, Michael F

2017-01-01

We identified six studies eligible for inclusion in this review; five RCTs and one NRS. Three completed RCTs (156 participants), one completed NRS (84 participants), and two ongoing RCTs. We identified one additional RCT awaiting classification. The completed studies were conducted between 1997 and 2015 and had a mean follow-up from 31 days to 2 years. One study included children receiving a HSCT (six participants), the other three studies only included adults: 218 participants with acute leukaemia receiving chemotherapy, and 16 with a haematological malignancy receiving a HSCT. The restrictive strategies varied from 70 g/L to 90 g/L. The liberal strategies also varied from 80 g/L to 120 g/L. Based on the GRADE rating methodology the overall quality of the included studies was very low to low across different outcomes. None of the included studies were free from bias for all ’Risk of bias’ domains. One of the three RCTs was discontinued early for safety concerns after recruiting only six children, all three participants in the liberal group developed veno-occlusive disease (VOD). Evidence from RCTs A restrictive RBC transfusion policy may make little or no difference to: the number of participants who died within 100 days (two trials, 95 participants (RR: 0.25, 95% CI 0.02 to 2.69, low-quality evidence); the number of participants who experienced any bleeding (two studies, 149 participants; RR:0.93, 95% CI 0.73 to 1.18, low-quality evidence), or clinically significant bleeding (two studies, 149 participants, RR: 1.03, 95% CI 0.75 to 1.43, low-quality evidence); the number of participants who required RBC transfusions (three trials; 155 participants: RR: 0.97, 95% CI 0.90 to 1.05, low-quality evidence); or the length of hospital stay (restrictive median 35.5 days (interquartile range (IQR): 31.2 to 43.8); liberal 36 days (IQR: 29.2 to 44), low-quality evidence). We are uncertain whether the restrictive RBC transfusion strategy: decreases quality of life (one trial

Tritium Studies in the United States. Geological Survey; Le tritium dans les etudes entreprises par le Service Geologique des Etats-Unis; Izuchenie tritiya v svyazi s geologicheskim obsledovaniem ssha; El tritio en los estudios del Servicio Geologico de los Estados Unidos

Energy Technology Data Exchange (ETDEWEB)

Carlston, C W; Thatcher, L L [United States Geological Survey, Washington, DC (United States)

1962-01-15

'yu uluchsheniya vosproizvodimosti i otsenki koeffitsientov otdeleniya v raznoobraznykh usloviyakh. Byla vyrabotana sistema, obespechivayushchaya pri obychnoj rabote 75-protsentnoe vosstanovlenie tritiya. Glavnye proekty na mestakh predstavlyayutsya v sleduyushchem vide: 1) Issledovanie pri pomoshchi ritiya pribrezhnoj doliny N'yu-Dzhersi pokazyvaet, chto nizhe gorizonta gruntovykh vod proiskhodit rassloenie vody v zavisimosti ot ee vozrasta. 2) V dvukh razlichnykh geologicheskikh gruntakh byli proizvedeny issledovaniya dlya opredeleniya sud'by radioaktivnykh osadkov tritiya posle ispytaniya termoyadernoj bomby v 1958 godu. 3) Tritij ispol'zuetsya dlya opredeleniya vosstanovleniya vodnykh apasov v tretichnykh peschanikakh podpochvennykh plastov polupustynny h loskogorij Novoj Meksiki. 4) Proizvoditsya issledovanie soderzhaniya tritiya v podpochvennykh vodakh doliny reki Snejk v Ajdakho dlya polucheniya svedenij otnositel'no vozrasta ehtoj vody, skorosti ee techeniya i ego napravleniya. 5) Iskusstvennyj tritij ispol'zuetsya v vide indikatora dlya opredeleniya emkosti podpochvennogo vodonosnogo bassejna vblizi Karlsbada, v Novoj Meksike. (author)

Desirable New Geologic Research in Support of Radioactive Waste Disposal as Indicated by Hanford Experience; Nouvelles Recherches Geologiques Souhaitables au Sujet de l'Elimination des Dechets Radioactifs, Selon les Indications Fournies par l'Experience de Hanford; 041f 0420 041e 0412 0415 0414 ; Nuevas Investigaciones Geologicas que Convendria Hacer para Facilitar la Evacuacion de Desechos Radiactivos Siguiendo las Indicaciones Proporcionadas por las Experiencias Efectuadas en Hanford

Energy Technology Data Exchange (ETDEWEB)

Brown, Randall E. [Hanford Laboratories, Hanford Atomic Products Operation, General Electric Company, Richland, WA (United States)

1960-07-01

estudios de los geologos, hidrologos, geoquimicos y matematicos ha contribuido mucho a asegurar la evacuacion sin riesgos de los desechos en el subsuelo de Hanford. No obstante, todavia queda mucho camino por recorrer. (author) [Russian] Ves process udalenija radioaktivnyh othodov zavisit ot geologicheskoj struktury okruzhajushhej sredy. No udalenie v jetu sredu ne javljaetsja okonchatel'nym, poskol'ku nikakoj material ne javljaetsja sovershenno nepronicaemym, nenas'ncajushhimsja ili nekorrozijnym s tochki zrenija geologicheskogo vremeni. Opyt v Hjenforde po udaleniju radioaktivnyh othodov podcherkivaet neobhodimost' sopostavlenija geologicheskih osobennostej, sushhestvujushhih v rajone udalenija otohodov i v blizhajshem rajone, gde vozmozhno obluchenie naselenija. Problemy, voznikshie v Hjenforde v svjazi s udaleniem radioaktivnyh othodov, vkljuchajut: 1. kolichestvennuju netochnost' geologii, 2. nedostatok izotopnyh, gomogennyh geologicheskih struktur, 3. opredelenie kolichestvennogo znachenija otklonenija geologicheskih i gidrologicheskih osobennostej ot normal'nogo polozhenija i 4. opredelenie i izmerenie parametrov, predstavljajushhih interes. Privodjatsja primery dlja illjustracii vysheukazannyh sluchaev. Bylo otryto 557 kolodcev obshhej glubinoj 33000 metrov, no dannye, poluchennye v rezul'tate jetoj bol'shoj raboty, nedostatochno tochny. Cennost' standartnyh akvifer- nyh ispytanij v rabochih uslovijah ogranichena, poskol'ku neobhodimye vvodnye dannye slishkom obobshhajutsja. Izuchenie ionnogo obmena daet kolichestvennye znachenija, kotorye predstavljajut neposredstvennyj interes i pomogajut istolkovat' geologicheskie osobennosti. Gidrologicheskie issledovanija, uvjazannye s rabotoj po himii pochvy i imejushhimisja geologicheskimi dannymi, okazyvajut pomoshh' v ob'jasnenii processa dvizhenija gruntovyh vod. Udalenie radioaktivnyh othodov v grunt ne javljaetsja ni panaceej, ni chem- to inym, chego sleduet bojat'sja. Obobshhenie dannyh, poluchennyh v rezul

Sampling Devices for Water and Soil; Methodes de Prelevement d'Echantillons dans l'Eau et le Sol; 041f 0420 0414 ; Dispositivos para Tomar Muestras de Agua y de Suelos

Energy Technology Data Exchange (ETDEWEB)

Merritt, W. F.; Parsons, P. J. [Environmental Research Branch, Division of Biology and Health Physics, Atomic Energy of Canada Limited, Chalk River, ON (Canada)

1960-07-01

gruntovyh vod. Rabotajushhij ot batarei schetchik Gejgera opuskaetsja po trube na provode. On mozhet ulavlivat' aktivnost' v 20-50 raspadov v minutu/millilitr Sr -90+U-90, rastvorennyh v gruntovoj vode. Special'no dlja jetogo razrabotan kompaktnyj gamma-spektrometr. Proby gruntovoj vody berutsja na opredelennyh glubinah s pomoshh'ju nakonechnikov Alunduma, soedinennyh s poverhnost'ju polijetilenovymi shlangami. Vzjatye proby vody perelivajutsja v kolbu, iz kotoroj otkachen vozduh. Neskol'ko takih nakonechnikov ili otbornikov mogut prisoedinjat'sja k sterzhnju, raspolozhennomu vnutri truby, pogruzhaemoj na trebuemuju glubinu, posle chego poslednjaja vynimaetsja, ostavljaja ih ukreplennymi v pochve. Esli grunt ne skalistyj, to poristye bronzovye p'ezometry mogut vdavlivat'sja ili vvodit'sja na ljubuju glubinu. Voda svobodno prohodit cherez takuju bronzu i sobiraetsja v kolbu, iz kotoroj otkachen vozduh. Iz odnoj skvazhiny mozhno s pomoshh'ju special'nyh ustrojstv dlja vzjatija prob, pomeshhennyh vnutr' svjazujushhej sekcii burovogo instrumenta, vzjat' po neskol'ku obrazcov pochvy s rjada predvaritel'no namechennyh glubin. Ustrojstvo dlja vzjatija prob predstavljaet polyj sterzhen' s bokovymi otverstijami, kotorye zakryty vo vremja burenija zaglushkami. Dlja vzjatija prob zaglushki slegka vytaskivajutsja, i sterzhen' povorachivaetsja. Zatem vytaskivaetsja vtoraja zaglushka, soedinennaja s pervoj, dlja togo chtoby zakryt' otverstie, i ustrojstva dlja vzjatija prob vytaskivajutsja iz skvazhiny. Proby peska, nahodjashhegosja nizhe gorizonta vody, berutsja s pomoshh'ju ustrojstva, snabzhennogo vozdushnym kolokolom, kotoryj pozvoljaet zabrat' probu v vozdushnuju polost' i uderzhivat' ee v trube pod davleniem vozduha poka vse ustrojstvo ne budet vynuto na poverhnost'. (author)

The effects of over sea height of locality on some chemical, health, microbiological, physical and technological parameters of cow milk and sensorical properties of cheeses

Directory of Open Access Journals (Sweden)

Oto Hanuš

2005-01-01

.The individual milk samples, feedstuff samples (total mixed ration (TMR on feeding trough and mean excrement samples were collected at seven dairy cow herds and two main milked breeds of cattle (in the CR for three years. Bulk milk samples were collected as well. It was done two times per year in winter (February, Marz and summer (August, September seasons. The herds were localised in lowland (N; ≤ 350 m of o.s.h. and highland (P; > 350 m of o.s.h. areas. The breed effect (H = Holstein and C = local Bohemian spotted cattle based on Simmental breed was good balanced between N and P areas. The milk yields of herds varied from 5500 to 10000 kg of milk per lactation. The different but typical varieties of nourishment and feeding systems of dairy cows were applied in the herds: N = alfalfa silage with maize silage; P = clover-grass silage, grass silage with maize silage and grass pasture as well. The concentrates were feeded according to milk yield and nutrition demand standards.Investigated chemical-compositional, physical, health and technological parameters in individual milk samples were as follows: daily milk yield (ML; kg of milk per day; fat content (Tuk; g/100ml; lactose content (Lak; g/100g of monohydrate; solids non fat (STP; g/100g; somatic cell count (PSB; tis./ml; urea content (Mo; mg/100ml; acetone concentration (Ac; mg/l; acidity, concentration of H ions (pH; electrical conductivity (Vod; mS/cm; alcohol stability (Alk; consumption of 96% ethanol to milk protein coagulation point; titratable acidity (SH; ml NaOH solution 2,5 mmol/l; time for enzymatic coa- gulation (Čas; sec.; rennet curds firmnes (PEV; mm in contrary sense; subjective estimation of rennet curds quality (KV; from 1st = good to 4th = bad; volume of the whey at rennet precipitation (SYR; in ml; crude protein content (HB; Kjeldahl total N×6,38; g/100g; casein content (KAS; Kjeldahl casein N×6,38; g/100g; true protein (ČB; Kjeldahl protein N×6,38; g/100g; whey protein (SB; difference ČB-KAS; g/100g

Short-Lived Isotopes Used as Tracers in Industry (with Special Reference to Swedish Industry); Emploi de Radioindicateurs de Courte Periode a l'Echelle Industrielie dans les Usines Suedoises; ПРИМЕНЕНИЕ КОРОТКОЖИВУЩИХ ИЗОТОПОВ В ПРОМЫШЛЕННОСТИ В КАЧЕСТВЕ МЕЧЕНЫХ АТОМОВ; Isotopos de Periodo Corto Utilizados Como Indicadores en la Industria Sueca

Energy Technology Data Exchange (ETDEWEB)

Erwall, L. G.; Forsberg, H. G.; Ljunggren, K. [Isotoptekniska Laboratoriet, Stockholm (Sweden)

1963-03-15

prestar asistencia a las empresas industriales proporcionandoles asesoiamiento, personal y los instrumentos necesarios para las aplicaciones industriales de los radioisotopos. (author) [Russian] Metody radioaktivnyh mechenyh atomov bystro nahodjat svoe priznanie kak neocenimoe sredstvo dlja issledovanij i kontrolja v promyshlennosti. Oni uhe uspeshno primenjalis' v avarijnyh sluchajah, pri issle- dovanii harakteristik proizvodstvennyh uzlov i kak vspomogatel'noe sredstvo pri konstruirovanii takih proizvodstvennyh uzlov. Dannyj obzor soderzhit tipichnye primery primenenija korotkozhivushhih mechenyh atomov, kotorye mogut byt' polucheny v umerennyh nejtronnyh potokah, naprimer,natrija-24, magnija-56, broma-62, lantana-140, a takzhe hlora-38, kalija-42 i zolota-196. S pomoshh'ju korotkozhivushhih izotopov mozhno proizvodit': - izuchenie prohozhdenija tverdyh veshhestv cherez proizvodstvennye uzly (vrashhavshiesja sushil'nye pechi, domennye pechi, celljuloznye avtoklavy, bashni dlja otbelki, sgustiteli Dorra) ; - opredelenie skorosti potoka zhidkostej v trubah i v otkrytyh ruslah (naprimer, dlja izmerenija obshego kolichestva potreblenija vody na ustanovke); - opredelenie vremeni nahozhdenija zaderzhki i ob{sup e}ma zhidkostej v razlichnyh tehnologicheskih uzlah v celljuloznoj i bumazhnoj promyshlennosti - ''vzveshivanie'' po metodu izotopnogo razbavlenija dlja opredelenija kolichestva shlakov v martenovskih pechah; - opredelenie proishozhdenija nemetallicheskih primesej v stali dlja izyskanija luchshih materialov dlja oblicovki i dlja usovershenstvovanija metodov otlivki; - mechenie dlja opredelenija kachestva, pozvoljajushhee ustanovit' s absoljutnoj dostovernost'ju jeksperimental'nye stal'nye plavki i specificheskie materialy v chernoj metallurgii; - opredelenie jeffektivnosti mesilok v betonnoj promyshlennosti; - sostavlenie diagramm potoka v bassejnah dlja stochnyh vod ili zhidkih othodov v celjah nahozhdenija nailuchshego mesta dlja spuska takih zhidkostej