WorldWideScience

Sample records for monitoring specific parameters

  1. Lagoon Monitoring and Condition Parameters

    OpenAIRE

    Harrison, John; Smith, Dallen

    2004-01-01

    Lagoons combine storage and tr eatment functions and thus are more sensitive to management inputs than are solid or slurry facilities. The est ablishment and maintenance of desirable microbiological populations in lagoons requires more specific procedures in the way lagoons are loaded and monitored.

  2. Application on drilling parameter monitor in drilling engineering monitoring

    Institute of Scientific and Technical Information of China (English)

    Shu DIAO; Zhenbao LING; Wenjing LIANG

    2008-01-01

    The drilling parameter monitor is an important tool in drilling engineering applied to monitoring drilling process, carrying out scientific analysis and decision-making. Based on discussing the present development situation of the domestic and foreign drilling machine parameter monitors, the metering scheme for vehicle-loaded drilling parameter monitor was designed. By using detection system for MSP430 single-chip microcomputer (SCM) in combination with peripheral circuit such as sensors, the drilling-rig control system was obtained to detect, and for every parameter in real-time display in order to keep operating the drilling rig status. The experiment shows that the drilling parameter monitor reaches design requirements and can be applied to drilling engineering monitoring, which has characters such as simple structure, high credibility and low cost.

  3. Correlation of PCDD/F and PCB concentrations in soil samples from the Swiss Soil Monitoring Network (NABO) to specific parameters of the observation sites

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, P.; Gujer, E.; Zennegg, M. [Swiss Federal Laboratories for Materials Testing and Research (EMPA), Duebendorf (Switzerland); Bucheli, T. [Agroscope FAL Reckenholz, Zuerich (Switzerland)

    2004-09-15

    Soils are natural sinks for persistent organic pollutants (POPs) such as polychlorinated dibenzo-pdioxins (PCDD/F) and polychlorinated biphenyls (PCB). Being lipophilic compounds, these contaminants adsorb to the organic carbon of the soil, and due to the low mobility and high persistence, they accumulate in the soil. Soil therefore represents rather a long-term archive for the atmospheric deposition than an indicator for the actual input of these compounds. In 1986, on demand of the Swiss ordinance of 9 June 1986 relating to hazardous substances in the soil, a national soil monitoring network (NABO) was set up in Switzerland aiming at monitoring the soil pollution. Sites were selected to reflect typical land use, vegetation, land management, air quality, and soil conditions in Switzerland. 50% of the sites are located on agricultural land, 30% in forests, and 20% on open land with extensive farming (alpine pastures, etc.); two sites are situated in urban parks. The sites are distributed throughout Switzerland including rural/remote areas as well as urban, urban fringe and industrial regions. Soil samples are taken every 5 years and are analysed for eight heavy metals (lead, copper, cadmium, zinc, nickel, chromium, cobalt, and mercury) as well as fluorine. So far, organic pollutants (PAH and PCB) have been determined in isolated samples only, and there is no data on PCDD/F concentrations so far. The present program was set up to fill this knowledge gap. A subset of 23 sites representing locations where contaminant immissions above average were expected was selected for PCDD/F and PCB analysis.

  4. Flexible carbon nanotube nanocomposite sensor for multiple physiological parameter monitoring

    KAUST Repository

    Nag, Anindya

    2016-10-16

    The paper presents the design, development, and fabrication of a flexible and wearable sensor based on carbon nanotube nanocomposite for monitoring specific physiological parameters. Polydimethylsiloxane (PDMS) was used as the substrate with a thin layer of a nanocomposite comprising functionalized multi-walled carbon nanotubes (MWCNTs) and PDMS as electrodes. The sensor patch functionalized on strain-sensitive capacitive sensing from interdigitated electrodes which were patterned with a laser on the nanocomposite layer. The thickness of the electrode layer was optimized regarding strain and conductivity. The sensor patch was connected to a monitoring device from one end and attached to the body on the other for examining purposes. Experimental results show the capability of the sensor patch used to detect respiration and limb movements. This work is a stepping stone of the sensing system to be developed for multiple physiological parameters.

  5. Groundwater pollution: are we monitoring appropriate parameters?

    CSIR Research Space (South Africa)

    Tredoux, G

    2004-01-01

    Full Text Available . In the literature, divergent approaches have identified various sets of pollutants and pollution indicators. This paper discusses international and local trends in groundwater monitoring for baseline studies and on-going pollution detection monitoring for a variety...

  6. Groundwater pollution: Are we monitoring appropriate parameters ...

    African Journals Online (AJOL)

    However, in practice groundwater quality monitoring is the main tool for timely ... quality is a specialised task for a hydrogeologist and a water quality monitoring expert. Although general prescriptions for waste management facilities exist these ... approaches have identified various sets of pollutants and pollution indicators.

  7. LIKELIHOOD ESTIMATION OF PARAMETERS USING SIMULTANEOUSLY MONITORED PROCESSES

    DEFF Research Database (Denmark)

    Friis-Hansen, Peter; Ditlevsen, Ove Dalager

    2004-01-01

    The topic is maximum likelihood inference from several simultaneously monitored response processes of a structure to obtain knowledge about the parameters of other not monitored but important response processes when the structure is subject to some Gaussian load field in space and time. The consi......The topic is maximum likelihood inference from several simultaneously monitored response processes of a structure to obtain knowledge about the parameters of other not monitored but important response processes when the structure is subject to some Gaussian load field in space and time....... The considered example is a ship sailing with a given speed through a Gaussian wave field....

  8. The development of power specific redlines for SSME safety monitoring

    Science.gov (United States)

    Maul, William A.; Bosch, Claudia M.

    1989-01-01

    Over the past several years, there has been an increased awareness in the necessity for rocket engine health monitoring because of the cost and complexity of present and future systems. A current rocket engine system, the Space Shuttle Main Engine (SSME), combines a limited redline system with closed-loop control of the engine's thrust level and mixture ratio. Despite these features, 27 tests of the SSME have resulted in major incidents. An SSME transient model was used to examine the effect of variations in high pressure turbopump performance on various engine parameters. Based on analysis of the responses, several new parameters are proposed for further investigation as power-level specific redlines.

  9. New fluorescence parameters for monitoring photosynthesis in plants.

    Science.gov (United States)

    Force, Lesleigh; Critchley, Christa; van Rensen, Jack J S

    2003-01-01

    Chlorophyll fluorescence measurements have a wide range of applications from basic understanding of photosynthesis functioning to plant environmental stress responses and direct assessments of plant health. The measured signal is the fluorescence intensity (expressed in relative units) and the most meaningful data are derived from the time dependent increase in fluorescence intensity achieved upon application of continuous bright light to a previously dark adapted sample. The fluorescence response changes over time and is termed the Kautsky curve or chlorophyll fluorescence transient. Recently, Strasser and Strasser (1995) formulated a group of fluorescence parameters, called the JIP-test, that quantify the stepwise flow of energy through Photosystem II, using input data from the fluorescence transient. The purpose of this study was to establish relationships between the biochemical reactions occurring in PS II and specific JIP-test parameters. This was approached using isolated systems that facilitated the addition of modifying agents, a PS II electron transport inhibitor, an electron acceptor and an uncoupler, whose effects on PS II activity are well documented in the literature. The alteration to PS II activity caused by each of these compounds could then be monitored through the JIP-test parameters and compared and contrasted with the literature. The known alteration in PS II activity of Chenopodium album atrazine resistant and sensitive biotypes was also used to gauge the effectiveness and sensitivity of the JIP-test. The information gained from the in vitro study was successfully applied to an in situ study. This is the first in a series of four papers. It shows that the trapping parameters of the JIP-test were most affected by illumination and that the reduction in trapping had a run-on effect to inhibit electron transport. When irradiance exposure proceeded to photoinhibition, the electron transport probability parameter was greatly reduced and dissipation

  10. Miniaturized pulse oximeter sensor for continuous vital parameter monitoring

    Science.gov (United States)

    Fiala, Jens; Reichelt, Stephan; Werber, Armin; Bingger, Philipp; Zappe, Hans; Förster, Katharina; Klemm, Rolf; Heilmann, Claudia; Beyersdorf, Friedhelm

    2007-07-01

    A miniaturized photoplethysmographic sensor system which utilizes the principle of pulse oximetry is presented. The sensor is designed to be implantable and will permit continuous monitoring of important human vital parameters such as arterial blood oxygen saturation as well as pulse rate and shape over a long-term period in vivo. The system employs light emitting diodes and a photo transistor embedded in a transparent elastic cu. which is directly wrapped around an arterial vessel. This paper highlights the specific challenges in design, instrumentation, and electronics associated with that sensor location. In vitro measurements were performed using an artificial circulation system which allows for regulation of the oxygen saturation and pulsatile pumping of whole blood through a section of a domestic pig's arterial vessel. We discuss our experimental results compared to reference CO-oximeter measurements and determine the empirical calibration curve. These results demonstrate the capabilities of the pulse oximeter implant for measurement of a wide range of oxygen saturation levels and pave the way for a continuous and mobile monitoring of high-risk cardiovascular patients.

  11. Smart Vest: wearable multi-parameter remote physiological monitoring system.

    Science.gov (United States)

    Pandian, P S; Mohanavelu, K; Safeer, K P; Kotresh, T M; Shakunthala, D T; Gopal, Parvati; Padaki, V C

    2008-05-01

    The wearable physiological monitoring system is a washable shirt, which uses an array of sensors connected to a central processing unit with firmware for continuously monitoring physiological signals. The data collected can be correlated to produce an overall picture of the wearer's health. In this paper, we discuss the wearable physiological monitoring system called 'Smart Vest'. The Smart Vest consists of a comfortable to wear vest with sensors integrated for monitoring physiological parameters, wearable data acquisition and processing hardware and remote monitoring station. The wearable data acquisition system is designed using microcontroller and interfaced with wireless communication and global positioning system (GPS) modules. The physiological signals monitored are electrocardiogram (ECG), photoplethysmogram (PPG), body temperature, blood pressure, galvanic skin response (GSR) and heart rate. The acquired physiological signals are sampled at 250samples/s, digitized at 12-bit resolution and transmitted wireless to a remote physiological monitoring station along with the geo-location of the wearer. The paper describes a prototype Smart Vest system used for remote monitoring of physiological parameters and the clinical validation of the data are also presented.

  12. Monitoring the Dead Sea Region by Multi-Parameter Stations

    Science.gov (United States)

    Mohsen, A.; Weber, M. H.; Kottmeier, C.; Asch, G.

    2015-12-01

    The Dead Sea Region is an exceptional ecosystem whose seismic activity has influenced all facets of the development, from ground water availability to human evolution. Israelis, Palestinians and Jordanians living in the Dead Sea region are exposed to severe earthquake hazard. Repeatedly large earthquakes (e.g. 1927, magnitude 6.0; (Ambraseys, 2009)) shook the whole Dead Sea region proving that earthquake hazard knows no borders and damaging seismic events can strike anytime. Combined with the high vulnerability of cities in the region and with the enormous concentration of historical values this natural hazard results in an extreme earthquake risk. Thus, an integration of earthquake parameters at all scales (size and time) and their combination with data of infrastructure are needed with the specific aim of providing a state-of-the-art seismic hazard assessment for the Dead Sea region as well as a first quantitative estimate of vulnerability and risk. A strong motivation for our research is the lack of reliable multi-parameter ground-based geophysical information on earthquakes in the Dead Sea region. The proposed set up of a number of observatories with on-line data access will enable to derive the present-day seismicity and deformation pattern in the Dead Sea region. The first multi-parameter stations were installed in Jordan, Israel and Palestine for long-time monitoring. All partners will jointly use these locations. All stations will have an open data policy, with the Deutsches GeoForschungsZentrum (GFZ, Potsdam, Germany) providing the hard and software for real-time data transmission via satellite to Germany, where all partners can access the data via standard data protocols.

  13. Adaptive Multichannel Radiation Sensors for Plant Parameter Monitoring

    Science.gov (United States)

    Mollenhauer, Hannes; Remmler, Paul; Schuhmann, Gudrun; Lausch, Angela; Merbach, Ines; Assing, Martin; Mollenhauer, Olaf; Dietrich, Peter; Bumberger, Jan

    2016-04-01

    Nutrients such as nitrogen are playing a key role in the plant life cycle. They are much needed for chlorophyll production and other plant cell components. Therefore, the crop yield is strongly affected by plant nutrient status. Due to the spatial and temporal variability of soil characteristics or swaying agricultural inputs the plant development varies within a field. Thus, the determination of these fluctuations in the plant development is valuable for a detection of stress conditions and optimization of fertilisation due to its high environmental and economic impact. Plant parameters play crucial roles in plant growth estimation and prediction since they are used as indicators of plant performance. Especially indices derived out of remote sensing techniques provide quantitative information about agricultural crops instantaneously, and above all, non-destructively. Due to the specific absorption of certain plant pigments, a characteristic spectral signature can be seen in the visible and IR part of the electromagnetic spectrum, known as narrow-band peaks. In an analogous manner, the presence and concentration of different nutrients cause a characteristic spectral signature. To this end, an adequate remote sensing monitoring concept is needed, considering heterogeneity and dynamic of the plant population and economical aspects. This work will present the development and field investigations of an inexpensive multichannel radiation sensor to observe the incoming and reflected specific parts or rather distinct wavelengths of the solar light spectrum on the crop and facilitate the determination of different plant indices. Based on the selected sensor wavelengths, the sensing device allows the detection of specific parameters, e.g. plant vitality, chlorophyll content or nitrogen content. Besides the improvement of the sensor characteristic, the simple wavelength adaption, and the price-performance ratio, the achievement of appropriate energy efficiency as well as a

  14. Tube-Load Model Parameter Estimation for Monitoring Arterial Hemodynamics

    Directory of Open Access Journals (Sweden)

    Guanqun eZhang

    2011-11-01

    Full Text Available A useful model of the arterial system is the uniform, lossless tube with parametric load. This tube-load model is able to account for wave propagation and reflection (unlike lumped-parameter models such as the Windkessel while being defined by only a few parameters (unlike comprehensive distributed-parameter models. As a result, the parameters may be readily estimated by accurate fitting of the model to available arterial pressure and flow waveforms so as to permit improved monitoring of arterial hemodynamics. In this paper, we review tube-load model parameter estimation techniques that have appeared in the literature for monitoring wave reflection, large artery compliance, pulse transit time, and central aortic pressure. We begin by motivating the use of the tube-load model for parameter estimation. We then describe the tube-load model, its assumptions and validity, and approaches for estimating its parameters. We next summarize the various techniques and their experimental results while highlighting their advantages over conventional techniques. We conclude the review by suggesting future research directions and describing potential applications.

  15. Tube-Load Model Parameter Estimation for Monitoring Arterial Hemodynamics

    Science.gov (United States)

    Zhang, Guanqun; Hahn, Jin-Oh; Mukkamala, Ramakrishna

    2011-01-01

    A useful model of the arterial system is the uniform, lossless tube with parametric load. This tube-load model is able to account for wave propagation and reflection (unlike lumped-parameter models such as the Windkessel) while being defined by only a few parameters (unlike comprehensive distributed-parameter models). As a result, the parameters may be readily estimated by accurate fitting of the model to available arterial pressure and flow waveforms so as to permit improved monitoring of arterial hemodynamics. In this paper, we review tube-load model parameter estimation techniques that have appeared in the literature for monitoring wave reflection, large artery compliance, pulse transit time, and central aortic pressure. We begin by motivating the use of the tube-load model for parameter estimation. We then describe the tube-load model, its assumptions and validity, and approaches for estimating its parameters. We next summarize the various techniques and their experimental results while highlighting their advantages over conventional techniques. We conclude the review by suggesting future research directions and describing potential applications. PMID:22053157

  16. Variability of multifractal parameters in an urban precipitation monitoring network

    Science.gov (United States)

    Licznar, Paweł; De Michele, Carlo; Dżugaj, Dagmara; Niesobska, Maria

    2014-05-01

    Precipitation especially over urban areas is considered a highly non-linear process, with wide variability over a broad range of temporal and spatial scales. Despite obvious limitations of rainfall gauges location at urban sites, rainfall monitoring by gauge networks is a standard solution of urban hydrology. Often urban precipitation gauge networks are formed by modern electronic gauges and connected to control units of centralized urban drainage systems. Precipitation data, recorded online through these gauge networks, are used in so called Real-Time-Control (RTC) systems for the development of optimal strategies of urban drainage outflows management. As a matter of fact, the operation of RTC systems is motivated mainly by the urge of reducing the severity of urban floods and combined sewerage overflows, but at the same time, it creates new valuable precipitation data sources. The variability of precipitation process could be achieved by investigating multifractal behavior displayed by the temporal structure of precipitation data. There are multiply scientific communications concerning multifractal properties of point-rainfall data from different worldwide locations. However, very little is known about the close variability of multifractal parameters among closely located gauges, at the distances of single kilometers. Having this in mind, here we assess the variability of multifractal parameters among gauges of the urban precipitation monitoring network in Warsaw, Poland. We base our analysis on the set of 1-minute rainfall time series recorded in the period 2008-2011 by 25 electronic weighing type gauges deployed around the city by the Municipal Water Supply and Sewerage Company in Warsaw as a part of local RTC system. The presence of scale invariance and multifractal properties in the precipitation process was investigated with spectral analysis, functional box counting method and studying the probability distributions and statistical moments of the rainfall

  17. The Specifications for Monitoring of Acid Rain

    Institute of Scientific and Technical Information of China (English)

    Tang Jie

    2011-01-01

    Background Since China is a country seriously affected by acid rain pollution,it is a long-term fundamental work for acid rain pollution prevention and control in China by getting well informed of the characteristics of spatial and temporal changes in acid rain and long-term trends of these changes.In order to reach the national demand for acid rain monitoring data,the China Meteorological Administration (CMA) began to construct the network of acid rain monitoring stations in 1992.By the end of 2010,the total number of monitoring stations has exceeded 340.

  18. Estimating a weighted average of stratum-specific parameters.

    Science.gov (United States)

    Brumback, Babette A; Winner, Larry H; Casella, George; Ghosh, Malay; Hall, Allyson; Zhang, Jianyi; Chorba, Lorna; Duncan, Paul

    2008-10-30

    This article investigates estimators of a weighted average of stratum-specific univariate parameters and compares them in terms of a design-based estimate of mean-squared error (MSE). The research is motivated by a stratified survey sample of Florida Medicaid beneficiaries, in which the parameters are population stratum means and the weights are known and determined by the population sampling frame. Assuming heterogeneous parameters, it is common to estimate the weighted average with the weighted sum of sample stratum means; under homogeneity, one ignores the known weights in favor of precision weighting. Adaptive estimators arise from random effects models for the parameters. We propose adaptive estimators motivated from these random effects models, but we compare their design-based performance. We further propose selecting the tuning parameter to minimize a design-based estimate of mean-squared error. This differs from the model-based approach of selecting the tuning parameter to accurately represent the heterogeneity of stratum means. Our design-based approach effectively downweights strata with small weights in the assessment of homogeneity, which can lead to a smaller MSE. We compare the standard random effects model with identically distributed parameters to a novel alternative, which models the variances of the parameters as inversely proportional to the known weights. We also present theoretical and computational details for estimators based on a general class of random effects models. The methods are applied to estimate average satisfaction with health plan and care among Florida beneficiaries just prior to Medicaid reform.

  19. Monitoring of conventional environmental parameters at CERN Annual Report 2004

    CERN Document Server

    Dziewa, A

    2005-01-01

    The monitoring programme for conventional environmental parameters at CERN comprises the control of water released from CERN installations, checks of water quality in rivers receiving water from CERN and monitoring of ambient air quality at places close to the CERN sites. The control of released water includes continuous monitoring of pH and temperature at six CERN water outlets and periodical sampling and analysis campaigns to check in more details the quality of the water released from the CERN sites. Sporadic river-water analyses and regular measurements of pH, temperature, concentration of dissolved oxygen and conductivity, were performed in the water of the rivers Nant d'Avril (CH) and Le Lion (F) as well as in the water of the streams around the seven LHC sites PA2 − PA8. The concentrations of nitrogen oxides and ozone in the ambient air, which may be produced in accelerator facilities and released into the environment, were measured at two off-site monitoring stations in Maisonnex (CH) and Cessy (F)....

  20. Monitoring of conventional environmental parameters at CERN Annual Report 2003

    CERN Document Server

    Kleiner, S

    2004-01-01

    The monitoring programme for conventional environmental parameters at CERN comprises the control of water released from CERN installations, checks of water quality in rivers receiving water from CERN and monitoring of ambient air quality at places close to the CERN sites. The control of released water includes continuous monitoring of pH and temperature at six CERN water outlets and periodical sampling and analysis campaigns to check in more details the quality of the water released from the CERN sites. Regular measurements of pH, temperature, concentration of dissolved oxygen and conductivity were performed in the water of the rivers Nant d'Avril (CH) and Le Lion (F) as well as in the water of the streams around the seven LHC sites PA2 − PA8. The concentrations of nitrogen oxides and ozone in the ambient air, which may be produced in accelerator facilities and released into the environment, were measured at two off-site monitoring stations in Maisonnex (CH) and Cessy (F). The report summarises the results ...

  1. Coral Reef Monitoring: From Cytological Parameters to Community Indices

    Directory of Open Access Journals (Sweden)

    Ofer Ben-Tzvi

    2011-01-01

    Full Text Available Sound-ecosystem-based management of coral reefs is largely based on indicators of reef health state. Currently there are various ecological parameters that serve as reef state indices; however, their practical implications are under debate. In the present study we examine an alternative parameter, the deterioration index (DI, which does not purport to replace the traditional indices but can provide a reliable, stand-alone indication of reef state. Patterns of cytological indices, which are considered as reliable indicators of environmental stressors, have been compared to ten selected reef community indices. The DI showed the highest correlations among community indices to the cytological indices in artificial reefs and high correlation in natural reefs as well. Our results suggest that in cases of lacking adequate monitoring abilities where a full set of community indices cannot be obtained, the DI can serve in many cases as the preferred, stand-alone indicator of coral reef state.

  2. Monitor of dynamic parameters in real time; Monitor de parametros dinamicos en tiempo real

    Energy Technology Data Exchange (ETDEWEB)

    Rojas S, A.S.; Ruiz E, J.A. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico)

    2008-07-01

    In the complex physical systems exist parameters that are necessary for monitoring in real time. In the nuclear industry, particularly in a reactor this surveillance is important, where the times of the reactions are almost instantaneous. Although many of these parameters are monitored, given the advance of the computer systems the monitoring could either be enlarged direct or indirect of other parameters. The analysis of the neutron noise in the nuclear reactors, plays an important role, the noise signal it contains information about the operation conditions of a system, when analyzing it with analysis methodologies of analogical signals to provide important information for the early detection of possible flaws and to indicate the permissible operation levels. To show the characteristics of the operation of the system of Monitoring of Dynamic Parameters in Real Time, oscillations of neutron noise of the TRIGA Mark III of the ININ were analyzed, these were caused with the control bar to a power of 10 Watts, the oscillations were carried out to a frequency of 1Hz, signal of low frequency. In this work a virtual instrument that allows by means of the spectral analysis method in frequency point by point is presented, to indicate in real time periodic variations that could be presented in the neutron noise signal, visualizing in advance the dynamic behavior of the system or nuclear plant. Another of the tests of the monitoring system presented is that of the oscillatory event happened in the reactor of Laguna Verde Nucleo electric Central, would be convenient to have an instrument of surveillance for monitoring through the neutron noise signal the behavior of some important parameter to predict and to indicate in an immediate way an abnormal condition in the reactor operation or in the plant system. These parameters can be the power, the recirculation water flow, etc. The monitor is based on a personal computer (PC), a data acquisition card (ADC) and a computer program

  3. Instrumentation of Lysimeter Experiments and Monitoring of Soil Parameters

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, T.; Tallos, A.; Millan, R.; Vera, R.; Recreo, F.

    2004-07-01

    This study forms part of the project Mercurio and Recuperation de Terrenos Afectados por Mercurio Ambiental (RETAMA), which determines the behaviour of mercury in the soil-plant system within the area of Almaden. The objective of this work is to instrument lysimeters with a set of electronic sensors to monitor physical and chemical soil parameters (moisture content, soil temperature, soil water matrix potential. Eh and pH) over a period of a complete vegetation cycle for selected crops. Physical and chemical soil analyses have been carried out on samples two soil profiles marking the extreme perimeter where the lysimeters were extracted. The monitoring data obtained every half hour show that the physicochemical conditions of the soils in the lysimeter can be correlated with the type of cultivation in the lysimeters. The results for parameters such as soil water matrix potential and the soil temperature reflect the diurnal changes; and fluctuations of the Eh can be related to the biological activities in the soils and are within oxid and suboxic conditions. Slight fluctuations have been observed for the pH and constant volumetric moisture content is maintained during the period of no hydric stress. (Author) 16 refs.

  4. Optimizing bowtie structure parameters for specific incident light

    Institute of Scientific and Technical Information of China (English)

    Wang Qiao; WU Shi-Fa; Li Xu-Feng; Wang Xiao-Gang

    2010-01-01

    We investigate optical properties of a bowtie-shaped aperture using the finite difference time domain method to optimize its geometric parameters for specific incident lights. The influence of the parameters on local field enhancement and resonant wavelength in the visible frequency range is numerically analysed. It is found that the major resonance of the spectrum is exponentially depended on the bowtie angle but independent of the whole aperture size. The simulation also demonstrates that increasing the aperture size raises the local field intensity on the exit plane due to an enlarged interaction area between the light and the metal medium. And the near-field spot size is closely related to the gap.Based on these results, the design rules of the bowtie structure can be optimized for specific wavelengths excited.

  5. 46 CFR 162.050-25 - Cargo monitor: Design specification.

    Science.gov (United States)

    2010-10-01

    ..., AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Pollution Prevention Equipment § 162... cause formation of static electricity. (e) A monitor must be designed to operate in each plane that forms an angle of 22.5° with the plane of its normal operating position. (f) Each monitor must...

  6. Double Shell Tank (DST) Monitor and Control Subsystem Specification

    Energy Technology Data Exchange (ETDEWEB)

    BAFUS, R.R.

    2000-11-03

    This specification revises the performance requirements and provides references to the requisite codes and standards to be applied during design of the Double-Shell Tank (DST) Monitor and Control Subsystem that supports the first phase of Waste Feed Delivery.

  7. Automated Synthesis of Assertion Monitors using Visual Specifications

    CERN Document Server

    Gadkari, Ambar A

    2011-01-01

    Automated synthesis of monitors from high-level properties plays a significant role in assertion-based verification. We present here a methodology to synthesize assertion monitors from visual specifications given in CESC (Clocked Event Sequence Chart). CESC is a visual language designed for specifying system level interactions involving single and multiple clock domains. It has well-defined graphical and textual syntax and formal semantics based on synchronous language paradigm enabling formal analysis of specifications. In this paper we provide an overview of CESC language with few illustrative examples. The algorithm for automated synthesis of assertion monitors from CESC specifications is described. A few examples from standard bus protocols (OCP-IP and AMBA) are presented to demonstrate the application of monitor synthesis algorithm.

  8. Integrated system for remotely monitoring critical physiological parameters

    Science.gov (United States)

    Alexakis, S.; Karalis, S.; Asvestas, P.

    2015-09-01

    Monitoring several human parameters (temperature, heart rate, blood pressure etc.) is an essential task in health care in hospitals as well as in home care. This paper presents the design and implementation of an integrated, embedded system that includes an electrocardiograph of nine leads and two channels, a digital thermometer for measuring the body temperature and a power supply. The system provides networking capabilities (wired or wireless) and is accessible by means of a web interface that allows the user to select the leads, as well as to review the values of heart rate (beats per minute) and body temperature. Furthermore, there is the option of saving all the data in a Micro SD memory card or in a Google Spreadsheet. The necessary analog circuits for signal conditioning (amplification and filtering) were manufactured on printed circuit boards (PCB). The system was built around Arduino Yun, which is a platform that contains a microcontroller and a microprocessor running a special LINUX distribution. Furthermore, the Arduino Yun provides the necessary network connectivity capabilities by means of the integrated Wi-Fi and Ethernet interfaces. The web interface was developed using HTML pages with JavaScript support. The system was tested on simulated data as well as real data, providing satisfactory accuracy regarding the measurement of the heart rate (±3 bpm error) and the temperature (±0.3°C error).

  9. Double Shell Tank (DST) Monitor and Control Subsystem Specification

    Energy Technology Data Exchange (ETDEWEB)

    BAFUS, R.R.

    2000-04-27

    This specification establishes the performance requirements and provides references to the requisite codes and standards to be applied during design of the Double-Shell Tank (DST) Monitor and Control Subsystem that supports the first phase of Waste Feed Delivery. This subsystem specification establishes the interface and performance requirements and provides references to the requisite codes and standards to be applied during the design of the Double-Shell Tank (DST) Monitor and Control Subsystem. The DST Monitor and Control Subsystem consists of the new and existing equipment that will be used to provide tank farm operators with integrated local monitoring and control of the DST systems to support Waste Feed Delivery (WFD). New equipment will provide automatic control and safety interlocks where required and provide operators with visibility into the status of DST subsystem operations (e.g., DST mixer pump operation and DST waste transfers) and the ability to manually control specified DST functions as necessary. This specification is intended to be the basis for new project/installations (W-521, etc.). This specification is not intended to retroactively affect previously established project design criteria without specific direction by the program.

  10. Reality monitoring impairment in schizophrenia reflects specific prefrontal cortex dysfunction

    Directory of Open Access Journals (Sweden)

    Jane R. Garrison

    2017-01-01

    Full Text Available Reality monitoring impairment is often reported in schizophrenia but the neural basis of this deficit is poorly understood. Difficulties with reality monitoring could be attributable to the same pattern of neural dysfunction as other cognitive deficits that characterize schizophrenia, or might instead represent a separable and dissociable impairment. This question was addressed through direct comparison of behavioral performance and neural activity associated with reality monitoring and working memory in patients with schizophrenia and matched healthy controls. Participants performed a word-pair reality monitoring task and a Sternberg working memory task while undergoing fMRI scanning. Distinct behavioral deficits were observed in the patients during performance of each task, which were associated with separable task- and region-specific dysfunction in the medial anterior prefrontal cortex for reality monitoring and dorsolateral prefrontal cortex for working memory. The results suggest that reality monitoring impairment is a distinct neurocognitive deficit in schizophrenia. The findings are consistent with the presence of a range of dissociable cognitive deficits in schizophrenia which may be associated with variable functional and structural dysconnectivity in underlying processing networks.

  11. Recommended environmental dose calculation methods and Hanford-specific parameters

    Energy Technology Data Exchange (ETDEWEB)

    Schreckhise, R.G.; Rhoads, K.; Napier, B.A.; Ramsdell, J.V. (Pacific Northwest Lab., Richland, WA (United States)); Davis, J.S. (Westinghouse Hanford Co., Richland, WA (United States))

    1993-03-01

    This document was developed to support the Hanford Environmental Dose overview Panel (HEDOP). The Panel is responsible for reviewing all assessments of potential doses received by humans and other biota resulting from the actual or possible environmental releases of radioactive and other hazardous materials from facilities and/or operations belonging to the US Department of Energy on the Hanford Site in south-central Washington. This document serves as a guide to be used for developing estimates of potential radiation doses, or other measures of risk or health impacts, to people and other biota in the environs on and around the Hanford Site. It provides information to develop technically sound estimates of exposure (i.e., potential or actual) to humans or other biotic receptors that could result from the environmental transport of potentially harmful materials that have been, or could be, released from Hanford operations or facilities. Parameter values and information that are specific to the Hanford environs as well as other supporting material are included in this document.

  12. Cell-specific monitoring of protein synthesis in vivo.

    Directory of Open Access Journals (Sweden)

    Nikos Kourtis

    Full Text Available Analysis of general and specific protein synthesis provides important information, relevant to cellular physiology and function. However, existing methodologies, involving metabolic labelling by incorporation of radioactive amino acids into nascent polypeptides, cannot be applied to monitor protein synthesis in specific cells or tissues, in live specimens. We have developed a novel approach for monitoring protein synthesis in specific cells or tissues, in vivo. Fluorescent reporter proteins such as GFP are expressed in specific cells and tissues of interest or throughout animals using appropriate promoters. Protein synthesis rates are assessed by following fluorescence recovery after partial photobleaching of the fluorophore at targeted sites. We evaluate the method by examining protein synthesis rates in diverse cell types of live, wild type or mRNA translation-defective Caenorhabditis elegans animals. Because it is non-invasive, our approach allows monitoring of protein synthesis in single cells or tissues with intrinsically different protein synthesis rates. Furthermore, it can be readily implemented in other organisms or cell culture systems.

  13. Strategies for experiment-specific monitoring in the Grid

    CERN Document Server

    Mendez Lorenzo, Patricia; Campana, Simone; Santinelli, Roberto; Lanciotti, Elisa; Miccio, Enzo; Magini, Nicolo; Di Girolamo, Alessandro

    2008-01-01

    This contribution describes how the LHC experiments implement their own Grid resource monitoring, either by internally developed tools, or by reusing tools used for Grid operations, like the Service Availability Monitor (SAM) used for the EGEE operations. The LHC experiments perform most, if not all, of their computing activities on Grid resources. This requires an accurate and updated picture of the status of the Grid services used by them, and of the services which are specific to the experiment. To achieve this, a common method is to periodically execute tests on the services, where the functionalities tested may be different from a VO to another. The SAM framework, developed for the EGEE operations, can be easily used to run and publish the results of arbitrary tests, from basic functionality tests, to high-level operations from real production activities. This contribution describes in detail how the monitoring system of each LHC experiment has taken advantage of SAM. The work covered by this contributio...

  14. Undersafe: Monitoring safety parameters in touristic mines and caves

    Science.gov (United States)

    Parcerisa, David; Sanmiquel, Lluís; Alfonso, Pura; Oliva, Josep

    2014-05-01

    Tourism is a key sector of the European economy, generating more than 5% of the EU GPD (Gross Domestic Product). Usually, underground touristic sites receive non-expert visitors; nevertheless these activities are poorly regulated or completely deregulated. Nowadays, safety is provided by underground expert professionals whom proceed to regular inspections and by basic safety infrastructures. Even with these measures, some potential personal and environmental dangers are always present and cannot be totally avoided. Therefore, there is a clear need of a new technological product for safety and environmental continuous monitoring of tourist underground attractions. So, the aim of the Undersafe project is to provide underground attractions with a novel and specifically tailored monitoring system, easy to use and maintain. One of the goals of the Undersafe project is to develop a rock falling detection based on a set of cost limited vibration sensors. Based on the technical needs, but with cost constraints, different types of potential sensors are considered: Underground microphone: It is placed in the surface or in the underground. It is based on the consideration that the impact of the stone generates a ground impact vibration which can be understood as a "noise" that is received by a microphone capsule. Airborne sound sensing microphone: It similarly applies to underground use of the microphones, but now the microphone is tested as for its traditional use (I.e. air sound detection). In such case, the microphone detects the environmental noise produced by the impact of the stone falling onto the ground, which will include the impact sound of the stone. Geophone: It is the de facto standard for ground vibrations. Although this technology was initially discarded due to its high cost, recently, low cost geophones have appeared in the market that allows its use inside the underground attractions. Accelerometers: These, can have enough sensibility to act as vibration

  15. SLALOM: a Language for SLA specification and monitoring

    CERN Document Server

    Correia, Anacleto; Amaral, Vasco

    2011-01-01

    IT services provisioning is usually underpinned by service level agreements (SLAs), aimed at guaranteeing services quality. However, there is a gap between the customer perspective (business oriented) and that of the service provider (implementation oriented) that becomes more evident while defining and monitoring SLAs. This paper proposes a domain specific language (SLA Language for specificatiOn and Monitoring - SLALOM) to bridge the previous gap. The first step in SLALOM creation was factoring out common concepts, by composing the BPMN metamodel with that of the SLA life cycle, as described in ITIL. The derived metamodel expresses the SLALOM abstract syntax model. The second step was to write concrete syntaxes targeting different aims, such as SLA representation in process models. An example of SLALOM's concrete syntax model instantiation for an IT service sup-ported by self-service financial terminals is presented.

  16. Monitoring Key Parameters in Bioprocesses Using Near-Infrared Technology

    Directory of Open Access Journals (Sweden)

    Elena Tamburini

    2014-10-01

    Full Text Available Near-infrared spectroscopy (NIRS is known to be a rapid and non-destructive technique for process monitoring. Bioprocesses are usually complex, from both the chemical (ill-defined medium composition and physical (multiphase matrix aspects, which poses an additional challenge to the development of robust calibrations. We investigated the use of NIRS for on-line and in-line monitoring of cell, substrate and product concentrations, during aerobic and anaerobic bacterial fermentations, in different fermentation strategies. Calibration models were built up, then validated and used for the automated control of fermentation processes. The capability of NIR in-line to discriminate among differently shaped bacteria was tested.

  17. Specifications and applications of the technical code for monitoring of building and bridge structures in China

    Directory of Open Access Journals (Sweden)

    Y Yang

    2016-12-01

    Full Text Available Recently, the exclusive compulsory technical code (GB 50982-2014 for structural health monitoring of buildings and bridges in China has been developed and implemented. This code covers the majority of the field monitoring methods and stipulates the corresponding technical parameters for monitoring of high-rise structures, large-span spatial structures, bridges and base-isolated structures. This article first presents the comprehensive review and linear comparison of existing structural health monitoring codes and standards. Subsequently, the progress of the codification of GB 50982-2014 is imparted and its main features and specifications are summarized. Finally, in accordance with GB50982-2014, several representative structural health monitoring practical applications of large-scale infrastructures in China are exemplified to illustrate how this national code can bridge the gap between theory and practical applications of structural health monitoring. This technical code is an important milestone in the application of well-established structural health monitoring techniques into the realistic and complex engineering projects. Also, it can provide abundant and authoritative information for practitioners and researchers involving the structural health monitoring techniques.

  18. 40 CFR 141.87 - Monitoring requirements for water quality parameters.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Monitoring requirements for water... § 141.87 Monitoring requirements for water quality parameters. All large water systems, and all small... representative of water quality and treatment conditions throughout the system. (d) Monitoring after State...

  19. Monitoring diesel engine parameters based on FBG probe

    Science.gov (United States)

    Zhang, Hao; Jiang, Qi; Wang, Bao-yan; Wang, Jun-jie

    2016-09-01

    This paper proposes an unprecedented systematic approach for real-time monitoring the temperature and flow of diesel engine by using embedded fiber Bragg grating (FBG). By virtue of FBG's temperature effect, we design a novel sensitive FBG temperature sensing probe to measure the temperature of cylinder head and inlet flow of diesel engine. We also establish the corresponding software platform for intuitive data analysis. The experimental and complementary simulation results simultaneously demonstrate that the FBG-based optical fiber technique possesses extraordinary reproducibility and sensitivity, which makes it feasible to monitor the temperature and inlet flow of diesel engine. Our work can provide an effective way to evaluate the thermal load of cylinder head in diesel engine.

  20. Wearable wireless multi-parameter sensor module for physiological monitoring.

    Science.gov (United States)

    Liverud, Anders E; Vedum, Jon; Fleurey, Franck; Seeberg, Trine M

    2012-01-01

    Advances in low power technology have given new possibilities for continuous physiological monitoring in several domains such as health care with disease prevention and quality of care services and workers in harsh environment. A miniaturized, multifunctional sensor module that transmits sensor data wirelessly using Bluetooth Smart technology has been developed. The wireless communication link is influenced by factors like antenna orientation, reflections, interference and noise. Test results for signal strength measurements for the wireless transmission in various setups are given and discussed.

  1. Extracting source parameters from beam monitors on a chopper spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Abernathy, Douglas L [ORNL; Niedziela, Jennifer L [ORNL; Stone, Matthew B [ORNL

    2015-01-01

    The intensity distributions of beam monitors in direct-geometry time-of-flight neutron spectrometers provide important information about the instrument resolution. For short-pulse spallation neutron sources in particular, the asymmetry of the source pulse may be extracted and compared to Monte Carlo source simulations. An explicit formula using a Gaussian-convolved Ikeda-Carpenter distribution is given and compared to data from the ARCS instrument at the Spallation Neutron Source.

  2. Bayesian parameter inference from continuously monitored quantum systems

    DEFF Research Database (Denmark)

    Gammelmark, Søren; Mølmer, Klaus

    2013-01-01

    We review the introduction of likelihood functions and Fisher information in classical estimation theory, and we show how they can be defined in a very similar manner within quantum measurement theory. We show that the stochastic master equations describing the dynamics of a quantum system subject...... to a definite set of measurements provides likelihood functions for unknown parameters in the system dynamics, and we show that the estimation error, given by the Fisher information, can be identified by stochastic master equation simulations. For large parameter spaces we describe and illustrate the efficient...

  3. Parameters monitoring and control for flueric actuators testing syste

    Directory of Open Access Journals (Sweden)

    Tiberiu Adrian SALAORU

    2014-04-01

    Full Text Available A wide range of air supply parameters is needed for the flueric actuators testing in order to find their optimum working regime. A system for conditioning these parameters, namely pressure, temperature, mass and volume flow rate has been built for this purpose. The measured values are continuously stored on the PC hard drive and are checked automatically for keeping them in the normal operating range. In case any of them are going out of this range, this system warns the operator and performs automatic actions for limiting or partially or totally shutting down the system.

  4. Increasing the Performance and Reliability of Power Boiler by Monitoring Thermal and Strength Parameters

    OpenAIRE

    Sobota Tomasz

    2017-01-01

    The paper presents a method for determination of thermo-flow parameters for steam boilers. This method allows to perform the calculations of the boiler furnace chamber and heat flow rates absorbed by superheater stages. These parameters are important for monitoring the performance of the power unit. Knowledge of these parameters allows determining the degree of the furnace chamber slagging. The calculation can be performed in online mode and use to monitoring of steam boiler. The presented me...

  5. Monitoring of Robot Assisted Polishing through parameters of acoustic emission

    DEFF Research Database (Denmark)

    Lazarev, Ruslan; Top, Søren; Bilberg, Arne

    , the duration of each process stage and predict the end of process in a precise and unmanned way. This paper presents and analyses the utilization of acoustic emission for generation of control signals in the stone polishing process for achieving these control objectives in an industrial set-up prototype........ The determination of the point in time to change a polishing media or stop the process is needed for computer controlled functional surface generation. During the last years, several research works have been done in order to build grinding/polishing monitoring systems to determine process characteristics...

  6. Monitoring of Robot Assisted Polishing through parameters of acoustic emission

    DEFF Research Database (Denmark)

    Lazarev, Ruslan; Top, Søren; Bilberg, Arne

    The polishing process is essential for the surface generation of machine tooling components in advanced manufacturing. While robot assisted polishing is faster and more consistent than manual polishing, it can still consume a significant part of ma- chining time and operator presence time....... The determination of the point in time to change a polishing media or stop the process is needed for computer controlled functional surface generation. During the last years, several research works have been done in order to build grinding/polishing monitoring systems to determine process characteristics...

  7. Inference of Soil Hydrologic Parameters from Soil Moisture Monitoring Records

    Science.gov (United States)

    Chandler, D. G.; Seyfried, M. S.; McNamara, J. P.; Hwang, K.

    2015-12-01

    Soil moisture is an important control on hydrologic function, as it governs flux through the soil and responds to and determines vertical fluxes from and to the atmosphere, groundwater recharge and lateral fluxes through the soil. Most physically based hydrologic models require parameters to represent soil physical properties governing flow and retention of vadose water. The presented analysis compares four methods of objective analysis to determine field capacity, plant extraction limit (or permanent wilting point) and field saturated soil moisture content from decadal records of volumetric water content. These values are found as either data attractors or limits in the VWC records and may vary with interannual moisture availability. Results are compared to values from pedotransfer functions and discussed in terms of historic methods of measurement in soil physics.

  8. Multi-parameter numerical simulation of dynamic monitoring of rock deformation in deep mining

    Institute of Scientific and Technical Information of China (English)

    Li Juanjuan; Hu Mingshun; Ding Enjie; Kong Wei; Pan Dongming; Chen Shenen

    2016-01-01

    The level of deformation development of surrounding rocks is a vital predictor to evaluate impending coal mine disasters and it is important to establish accurate measurements of the deformed status to ensure coal mine safety. Traditional deformation monitoring methods are mostly based on single parameter, in this paper, multiple approaches are integrated: firstly, both electric and elastic models are established, from which electric field distribution and seismic wave recording are calculated and finally, the resistivity profiles and source position information are determined using inversion methods, from which then the deformation and failure of mine floor are evaluated. According to the inversion results of both electric and seismic field signals, multiple-parameter dynamic monitoring of surrounding rock deformation in deep mine can be performed. The methodology is validated using numerical simulation results which shows that the multi-parameter dynamic monitoring methods have better results for surrounding rock deformation in deep mine monitoring than single parameter methods.

  9. Animal based parameters are no panacea for on-farm monitoring of animal welfare

    NARCIS (Netherlands)

    Bracke, M.B.M.

    2007-01-01

    On-farm monitoring of animal welfare is an important, present-day objective in animal welfare science. Scientists tend to focus exclusively on animal-based parameters, possibly because using environment-based parameters could be begging the question why welfare has been affected and because animal-b

  10. Increasing the Performance and Reliability of Power Boiler by Monitoring Thermal and Strength Parameters

    Directory of Open Access Journals (Sweden)

    Sobota Tomasz

    2017-01-01

    Full Text Available The paper presents a method for determination of thermo-flow parameters for steam boilers. This method allows to perform the calculations of the boiler furnace chamber and heat flow rates absorbed by superheater stages. These parameters are important for monitoring the performance of the power unit. Knowledge of these parameters allows determining the degree of the furnace chamber slagging. The calculation can be performed in online mode and use to monitoring of steam boiler. The presented method allows to the operation of steam boiler with high efficiency.

  11. Monitoring a 5 MW offshore wind energy converter—Condition parameters and triangulation based extraction of modal parameters

    Science.gov (United States)

    Häckell, Moritz W.; Rolfes, Raimund

    2013-10-01

    The test field alpha ventus is the first operating German offshore parks for wind energy. Twelve Wind Energy Converters (WECs) of the 5 MW-class are installed, both, for commercial and research reasons. Due to upcoming mass production and uncertainties in loads and behaviour, monitoring the foundation of these structures was desired. Two goals addressed are the extraction of modal parameters for model validation and the estimation of condition parameters to allow a hypothesis of the system's state. In a first step the largedatabase is classified by Environmental and Operational Conditions (EOCs) through affinity propagation which is a new approach for Structural Health Monitoring (SHM) on wind turbines. Further, system identification through data driven stochastic subspace identification (SSI) is performed. A new, automated approach called triangulation-based extraction of modal parapeters (TEMP), using stability diagrams, is a key focus of the presented research. Finally, extraction of condition parameters for tower accelerations classified by EOCs, based on covariance driven SSI and Vector Auto-Regressive (VAR) Models, is performed for several observation periods from one to 16 weeks. These parameters and their distributions provide a base line for long term observations.

  12. Lumped Parameter Modeling as a Predictive Tool for a Battery Status Monitor

    Energy Technology Data Exchange (ETDEWEB)

    Jon P. Christophersen; Chester G. Motloch; Chinh D. Ho; John L. Morrison; Ronald C. Fenton; Vincent S. Battaglia; Tien Q. Duong

    2003-10-01

    The Advanced Technology Development Program is currently evaluating the performance of the second generation of lithium-ion cells (i.e., Gen 2 cells). Both the Gen 2 Baseline and Variant C cells are tested in accordance with the cell-specific test plan, and are removed at roughly equal power fade increments and sent for destructive diagnostic analysis. The diagnostic laboratories did not need all test cells for analysis, and returned five spare cells to the Idaho National Engineering and Environmental Laboratory (INEEL). INEEL used these cells for special pulse testing at various duty cycles, amplitudes, and durations to investigate the usefulness of the lumped parameter model (LPM) as a predictive tool in a battery status monitor (BSM). The LPM is a simplified linear model that accurately predicts the voltage response during certain pulse conditions. A database of parameter trends should enable dynamic predictions of state-of-charge and state-of-health conditions during in-vehicle pulsing. This information could be used by the BSM to provide accurate information to the vehicle control system.

  13. Monitoring of Physiological Parameters to Predict Exacerbations of Chronic Obstructive Pulmonary Disease (COPD: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Ahmed M. Al Rajeh

    2016-11-01

    Full Text Available Introduction: The value of monitoring physiological parameters to predict chronic obstructive pulmonary disease (COPD exacerbations is controversial. A few studies have suggested benefit from domiciliary monitoring of vital signs, and/or lung function but there is no existing systematic review. Objectives: To conduct a systematic review of the effectiveness of monitoring physiological parameters to predict COPD exacerbation. Methods: An electronic systematic search compliant with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA guidelines was conducted. The search was updated to April 6, 2016. Five databases were examined: Medical Literature Analysis and Retrieval System Online, or MEDLARS Online (Medline, Excerpta Medica dataBASE (Embase, Allied and Complementary Medicine Database (AMED, Cumulative Index of Nursing and Allied Health Literature (CINAHL and the Cochrane clinical trials database. Results: Sixteen articles met the pre-specified inclusion criteria. Fifteen of these articules reported positive results in predicting COPD exacerbation via monitoring of physiological parameters. Nine studies showed a reduction in peripheral oxygen saturation (SpO2% prior to exacerbation onset. Three studies for peak flow, and two studies for respiratory rate reported a significant variation prior to or at exacerbation onset. A particular challenge is accounting for baseline heterogeneity in parameters between patients. Conclusion: There is currently insufficient information on how physiological parameters vary prior to exacerbation to support routine domiciliary monitoring for the prediction of exacerbations in COPD. However, the method remains promising.

  14. The Roles of Mothers' Neighborhood Perceptions and Specific Monitoring Strategies in Youths' Problem Behavior

    Science.gov (United States)

    Byrnes, Hilary F.; Miller, Brenda A.; Chen, Meng-Jinn; Grube, Joel W.

    2011-01-01

    The neighborhood context can interfere with parents' abilities to effectively monitor their children, but may be related to specific monitoring strategies in different ways. The present study examines the importance of mothers' perceptions of neighborhood disorganization for the specific monitoring strategies they use and how each of these…

  15. An Integrated Environment Monitoring System for Underground Coal Mines—Wireless Sensor Network Subsystem with Multi-Parameter Monitoring

    Directory of Open Access Journals (Sweden)

    Yu Zhang

    2014-07-01

    Full Text Available Environment monitoring is important for the safety of underground coal mine production, and it is also an important application of Wireless Sensor Networks (WSNs. We put forward an integrated environment monitoring system for underground coal mine, which uses the existing Cable Monitoring System (CMS as the main body and the WSN with multi-parameter monitoring as the supplementary technique. As CMS techniques are mature, this paper mainly focuses on the WSN and the interconnection between the WSN and the CMS. In order to implement the WSN for underground coal mines, two work modes are designed: periodic inspection and interrupt service; the relevant supporting technologies, such as routing mechanism, collision avoidance, data aggregation, interconnection with the CMS, etc., are proposed and analyzed. As WSN nodes are limited in energy supply, calculation and processing power, an integrated network management scheme is designed in four aspects, i.e., topology management, location management, energy management and fault management. Experiments were carried out both in a laboratory and in a real underground coal mine. The test results indicate that the proposed integrated environment monitoring system for underground coal mines is feasible and all designs performed well as expected.

  16. Analyzing the performance of fluorescence parameters in the monitoring of leaf nitrogen content of paddy rice

    Science.gov (United States)

    Yang, Jian; Gong, Wei; Shi, Shuo; Du, Lin; Sun, Jia; Song, Shalei; Chen, Biwu; Zhang, Zhenbing

    2016-06-01

    Leaf nitrogen content (LNC) is a significant factor which can be utilized to monitor the status of paddy rice and it requires a reliable approach for fast and precise quantification. This investigation aims to quantitatively analyze the correlation between fluorescence parameters and LNC based on laser-induced fluorescence (LIF) technology. The fluorescence parameters exhibited a consistent positive linear correlation with LNC in different growing years (2014 and 2015) and different rice cultivars. The R2 of the models varied from 0.6978 to 0.9045. Support vector machine (SVM) was then utilized to verify the feasibility of the fluorescence parameters for monitoring LNC. Comparison of the fluorescence parameters indicated that F740 is the most sensitive (the R2 of linear regression analysis of the between predicted and measured values changed from 0.8475 to 0.9226, and REs ranged from 3.52% to 4.83%) to the changes in LNC among all fluorescence parameters. Experimental results demonstrated that fluorescence parameters based on LIF technology combined with SVM is a potential method for realizing real-time, non-destructive monitoring of paddy rice LNC, which can provide guidance for the decision-making of farmers in their N fertilization strategies.

  17. Design of wireless multi-parameter monitoring system for oral feeding of premature infants.

    Science.gov (United States)

    Wang, Yu-Lin; Kuo, Hsing-Chien; Wang, Lin-Yu; Ko, Mei-Ju; Lin, Bor-Shyh

    2016-07-01

    Premature infants often cannot successfully and coordinately complete their oral feeding. Mature sucking, swallowing, and respiration activities are crucial indicators for the survival of newborn infants. Due to the vulnerability and unobvious muscle activities of premature infants, current clinical care givers mainly depend on the subjective behavioral observation of infants during oral feeding. There is still lack of an integrated oral feeding monitoring system to objectively and quantifiably monitor the related physiological parameters of premature infants. In this study, a wireless multi-parameter monitoring system for oral feeding of premature infants was proposed to monitor the sucking-swallowing-respiratory activities and the heart rate variability to provide quantitative indices of oral feeding. Here, a novel sucking pressure sensing module was also developed to monitor the premature infant's sucking pressure under oral feeding to avoid the immersion influence of milk. The experimental results showed that the proposed system detected the related physiological parameters of premature infants during oral feeding effectively and may provide an objective clinical evaluation tool for oral feeding ability and safety of premature infants in the future.

  18. Validity of DynaPort GaitMonitor for assessment of spatiotemporal parameters in amputee gait

    NARCIS (Netherlands)

    Houdijk, Han; Appelman, Franka M; Van Velzen, Judith M; Van der Woude, Lucas H V; Van Bennekom, Coen A M

    2008-01-01

    Accelerometry can be used to objectively assess the walking ability of people with a lower-limb prosthesis inside and outside the laboratory setting. In this study, the validity of the DynaPort GaitMonitor software (McRoberts, The Hague, the Netherlands) for assessing spatiotemporal parameters of am

  19. Monitoring of the electrical parameters in off-grid solar power system

    Science.gov (United States)

    Idzkowski, Adam; Leoniuk, Katarzyna; Walendziuk, Wojciech

    2016-09-01

    The aim of this work was to make a monitoring dedicated to an off-grid installation. A laboratory set, which was built for that purpose, was equipped with a PV panel, a battery, a charge controller and a load. Additionally, to monitor electrical parameters from this installation there were used: LabJack module (data acquisition card), measuring module (self-built) and a computer with a program, which allows to measure and present the off-grid installation parameters. The program was made in G language using LabVIEW software. The designed system enables analyzing the currents and voltages of PV panel, battery and load. It makes also possible to visualize them on charts and to make reports from registered data. The monitoring system was also verified by a laboratory test and in real conditions. The results of this verification are also presented.

  20. 40 CFR 75.14 - Specific provisions for monitoring opacity.

    Science.gov (United States)

    2010-07-01

    ... calendar year. (d) Diesel-fired units and dual-fuel reciprocating engine units. The owner or operator of an affected diesel-fired unit or a dual-fuel reciprocating engine unit is exempt from the opacity monitoring... unit by changing its fuel mix, the owner or operator shall install, operate, and certify a continuous...

  1. Thermal Regime and Meteorological Parameters Monitoring in Alpine Permafrost Rockwalls: the Aiguille du Midi

    Science.gov (United States)

    Morra di Cella, U.; Cremonese, E.; Deline, P.; Gruber, S.; Pogliotti, P.; Ravanel, L.

    2009-04-01

    During the last decades the alpine region has revealed to be extremely sensitive to ongoing increasing temperatures and permafrost has been identified as one of six cryospheric indicators of global climate change. In high-mountain regions the permafrost evidences are scarse and punctual, while its occurrence is wide and its distribution is mainly controlled by complex topography and ground cover condition. In such environment, steep bedrock slopes are abundant and contain a significant proportion of permafrost whose thermal response is very fast compared to permafrost in gentle morphology because of its less amount of ice content. Due to logistical problems like accessibility, costs, weather conditions, etc..., monitoring sites in such environments are few, while an increase of measurements of rockwall temperature and system energy balance is fundamental for the calibration and validation of both physical and statistical permafrost models. Started in the framework of the French-Italian project PERMAdataROC (www.fondazionemontagnasicura.org/multimedia/permadataroc/) and presently developped within the EU co-funded project PermaNET (www.permanet-alpinespace.eu), several monitoring sites have been equipped during the last years in the Western Alps from a collaboration of Swiss, French and Italian researchers, with the aim to cover the widest range of climatic, topographic, morphological and geological conditions. In such network, the Aiguille du Midì can be considered one of the most advanced site in high-mountain permafrost research thanks to the convergence of several instrumental approaches, but also a "cooperation laboratory" among different research groups. The site has been choosen because of its elevation, aspects variability, steep slopes and accessibility all over the year. In details, ARPA Valle d'Aosta in collaboration with University of Zurich started in 2006 the monitoring of rockwall thermal regimes and of some meteorological parameters on the different

  2. A real time dose monitoring and dose reconstruction tool for patient specific VMAT QA and delivery

    Energy Technology Data Exchange (ETDEWEB)

    Tyagi, Neelam; Yang Kai; Gersten, David; Yan Di [Department of Radiation Oncology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, Michigan 48073 (United States)

    2012-12-15

    Purpose: To develop a real time dose monitoring and dose reconstruction tool to identify and quantify sources of errors during patient specific volumetric modulated arc therapy (VMAT) delivery and quality assurance. Methods: The authors develop a VMAT delivery monitor tool called linac data monitor that connects to the linac in clinical mode and records, displays, and compares real time machine parameters with the planned parameters. A new measure, called integral error, keeps a running total of leaf overshoot and undershoot errors in each leaf pair, multiplied by leaf width, and the amount of time during which the error exists in monitor unit delivery. Another tool reconstructs Pinnacle{sup 3} Trade-Mark-Sign format delivered plan based on the saved machine logfile and recalculates actual delivered dose in patient anatomy. Delivery characteristics of various standard fractionation and stereotactic body radiation therapy (SBRT) VMAT plans delivered on Elekta Axesse and Synergy linacs were quantified. Results: The MLC and gantry errors for all the treatment sites were 0.00 {+-} 0.59 mm and 0.05 {+-} 0.31 Degree-Sign , indicating a good MLC gain calibration. Standard fractionation plans had a larger gantry error than SBRT plans due to frequent dose rate changes. On average, the MLC errors were negligible but larger errors of up to 6 mm and 2.5 Degree-Sign were seen when dose rate varied frequently. Large gantry errors occurred during the acceleration and deceleration process, and correlated well with MLC errors (r= 0.858, p= 0.0004). PTV mean, minimum, and maximum dose discrepancies were 0.87 {+-} 0.21%, 0.99 {+-} 0.59%, and 1.18 {+-} 0.52%, respectively. The organs at risk (OAR) doses were within 2.5%, except some OARs that showed up to 5.6% discrepancy in maximum dose. Real time displayed normalized total positive integral error (normalized to the total monitor units) correlated linearly with MLC (r= 0.9279, p < 0.001) and gantry errors (r= 0.742, p= 0.005). There

  3. Optimal design of monitoring networks for multiple groundwater quality parameters using a Kalman filter: application to the Irapuato-Valle aquifer.

    Science.gov (United States)

    Júnez-Ferreira, H E; Herrera, G S; González-Hita, L; Cardona, A; Mora-Rodríguez, J

    2016-01-01

    A new method for the optimal design of groundwater quality monitoring networks is introduced in this paper. Various indicator parameters were considered simultaneously and tested for the Irapuato-Valle aquifer in Mexico. The steps followed in the design were (1) establishment of the monitoring network objectives, (2) definition of a groundwater quality conceptual model for the study area, (3) selection of the parameters to be sampled, and (4) selection of a monitoring network by choosing the well positions that minimize the estimate error variance of the selected indicator parameters. Equal weight for each parameter was given to most of the aquifer positions and a higher weight to priority zones. The objective for the monitoring network in the specific application was to obtain a general reconnaissance of the water quality, including water types, water origin, and first indications of contamination. Water quality indicator parameters were chosen in accordance with this objective, and for the selection of the optimal monitoring sites, it was sought to obtain a low-uncertainty estimate of these parameters for the entire aquifer and with more certainty in priority zones. The optimal monitoring network was selected using a combination of geostatistical methods, a Kalman filter and a heuristic optimization method. Results show that when monitoring the 69 locations with higher priority order (the optimal monitoring network), the joint average standard error in the study area for all the groundwater quality parameters was approximately 90 % of the obtained with the 140 available sampling locations (the set of pilot wells). This demonstrates that an optimal design can help to reduce monitoring costs, by avoiding redundancy in data acquisition.

  4. Parameter specification for the degree distribution of simulated Barabási-Albert graphs

    Science.gov (United States)

    Mohd-Zaid, Fairul; Kabban, Christine M. Schubert; Deckro, Richard F.; White, Edward D.

    2017-01-01

    The degree distribution of a simulated Barabási-Albert graph under linear preferential attachment is investigated. Specifically, the parameters of the power law distribution are estimated and compared against the theoretical values derived using mean field theory. Least squares method and MLE-nonparametric method were utilized to estimate the distribution parameters on 1000 simulated Barabási-Albert graphs for edge parameter m ∈ { 2 , 4 , 6 } and size n ∈ {2k : k = 5 , 6 , … , 14 , 15 } . Goodness of fit metrics were computed on a second set of simulated graphs for the median of the estimated parameters and other hypothetical values for the distribution parameters. The results suggest that the distribution of the parameters from simulated graphs are significantly different from the theoretical distribution and is also dependent on m. Further results confirm the finding that the parameter of the power law distribution, β, increases as m increases.

  5. Design of Tropical Flowers Environmental Parameters Wireless Monitoring System Based on MSP430

    Directory of Open Access Journals (Sweden)

    Huang Jian-Qing

    2016-01-01

    Full Text Available Considering the importance of real-time monitoring tropical flower environment parameters, the paper designs a wireless monitoring system based on MSP430F149 for tropical flower growing parameters. The proposed system uses sensor nodes to obtain data of temperature, humidity and light intensity, sink node to collect data from sensor nodes through wireless sensor network, and monitoring center to process data downloaded from the sink node through RS232 serial port. The node hardware platform is composed of a MSP430F149 processor, AM2306 and NHZD10AI sensors used to adopt temperature, humidity and light intensity data, and an nRF905 RF chip used to receive and send data. The node software, operated in IAR Embedded Workbench, adopts C Language to do node data collection and process, wireless transmission and serial port communication. The software of monitoring center develops in VB6.0, which can provide vivid and explicit real-time monitoring platform for flower farmers.

  6. Research on multi-parameter monitoring of steel frame shaking-table test using smartphone

    Science.gov (United States)

    Han, Ruicong; Loh, Kenneth J.; Zhao, Xuefeng; Yu, Yan

    2017-04-01

    The numerical simulation promises an effective method to assess seismic damage of high-rise structure. But it's difficult to determine the input parameters and the simulation results are not completely consistent with the real condition. A more direct approach to evaluate the seismic damage is the structural health monitoring (SHM), which is one complex set of various kinds of sensors, devices and software, and always needs professionals. SHM system has achieved great development over recent years, especially on bridge structures. However it's not so popular on high-rise building due to its difficult implementation. Developing a low-cost and convenient monitoring technique will be helpful for the safety maintenance of high-rise building. Smartphones, which embedded with sensors, network transmission, data storage and processing system, are evolving towards crowdsourcing. The popularity of smartphones presents opportunities for implementation of portable SHM system on buildings. In this paper, multi-parameter monitoring of a three-story steel frame on shaking table under earthquake excitations was conducted with smartphone, and the comparison between smartphone and traditional sensors was provided. First, the monitoring applications on iOS platform, Orion-CC and D-viewer, were introduced. Then the experimental details were presented, including three-story frame model, sensors placement, viscous dampers and so on. Last, the acceleration and displacement time-history curves of smartphone and traditional sensors are provided and compared to prove the feasibility of the monitoring on frame under earthquake excitations by smartphone.

  7. Monitoring biodiesel reactions of soybean oil and sunflower oil using ultrasonic parameters

    Science.gov (United States)

    Figueiredo, M. K. K.; Silva, C. E. R.; Alvarenga, A. V.; Costa-Félix, R. P. B.

    2015-01-01

    Biodiesel is an innovation that attempts to substitute diesel oil with biomass. The aim of this paper is to show the development of a real-time method to monitor transesterification reactions by using low-power ultrasound and pulse/echo techniques. The results showed that it is possible to identify different events during the transesterification process by using the proposed parameters, showing that the proposed method is a feasible way to monitor the reactions of biodiesel during its fabrication, in real time, and with relatively low- cost equipment.

  8. Dynamic Parameter Identification of Subject-Specific Body Segment Parameters Using Robotics Formalism: Case Study Head Complex.

    Science.gov (United States)

    Díaz-Rodríguez, Miguel; Valera, Angel; Page, Alvaro; Besa, Antonio; Mata, Vicente

    2016-05-01

    Accurate knowledge of body segment inertia parameters (BSIP) improves the assessment of dynamic analysis based on biomechanical models, which is of paramount importance in fields such as sport activities or impact crash test. Early approaches for BSIP identification rely on the experiments conducted on cadavers or through imaging techniques conducted on living subjects. Recent approaches for BSIP identification rely on inverse dynamic modeling. However, most of the approaches are focused on the entire body, and verification of BSIP for dynamic analysis for distal segment or chain of segments, which has proven to be of significant importance in impact test studies, is rarely established. Previous studies have suggested that BSIP should be obtained by using subject-specific identification techniques. To this end, our paper develops a novel approach for estimating subject-specific BSIP based on static and dynamics identification models (SIM, DIM). We test the validity of SIM and DIM by comparing the results using parameters obtained from a regression model proposed by De Leva (1996, "Adjustments to Zatsiorsky-Seluyanov's Segment Inertia Parameters," J. Biomech., 29(9), pp. 1223-1230). Both SIM and DIM are developed considering robotics formalism. First, the static model allows the mass and center of gravity (COG) to be estimated. Second, the results from the static model are included in the dynamics equation allowing us to estimate the moment of inertia (MOI). As a case study, we applied the approach to evaluate the dynamics modeling of the head complex. Findings provide some insight into the validity not only of the proposed method but also of the application proposed by De Leva (1996, "Adjustments to Zatsiorsky-Seluyanov's Segment Inertia Parameters," J. Biomech., 29(9), pp. 1223-1230) for dynamic modeling of body segments.

  9. Updating Parameters for Volcanic Hazard Assessment Using Multi-parameter Monitoring Data Streams And Bayesian Belief Networks

    Science.gov (United States)

    Odbert, Henry; Aspinall, Willy

    2014-05-01

    Evidence-based hazard assessment at volcanoes assimilates knowledge about the physical processes of hazardous phenomena and observations that indicate the current state of a volcano. Incorporating both these lines of evidence can inform our belief about the likelihood (probability) and consequences (impact) of possible hazardous scenarios, forming a basis for formal quantitative hazard assessment. However, such evidence is often uncertain, indirect or incomplete. Approaches to volcano monitoring have advanced substantially in recent decades, increasing the variety and resolution of multi-parameter timeseries data recorded at volcanoes. Interpreting these multiple strands of parallel, partial evidence thus becomes increasingly complex. In practice, interpreting many timeseries requires an individual to be familiar with the idiosyncrasies of the volcano, monitoring techniques, configuration of recording instruments, observations from other datasets, and so on. In making such interpretations, an individual must consider how different volcanic processes may manifest as measureable observations, and then infer from the available data what can or cannot be deduced about those processes. We examine how parts of this process may be synthesised algorithmically using Bayesian inference. Bayesian Belief Networks (BBNs) use probability theory to treat and evaluate uncertainties in a rational and auditable scientific manner, but only to the extent warranted by the strength of the available evidence. The concept is a suitable framework for marshalling multiple strands of evidence (e.g. observations, model results and interpretations) and their associated uncertainties in a methodical manner. BBNs are usually implemented in graphical form and could be developed as a tool for near real-time, ongoing use in a volcano observatory, for example. We explore the application of BBNs in analysing volcanic data from the long-lived eruption at Soufriere Hills Volcano, Montserrat. We discuss

  10. Design of GLP lab environment parameters monitor system based on Schneider PLC

    Science.gov (United States)

    Lian, Xiaoqin; Xu, Huihui; Duan, Zhengang; Zhang, Yong

    2008-10-01

    According to the technological process and the requirement for system control of the GLP Laboratory, an automatic system is designed to monitor and control over the environment parameters of the GLP laboratory. The system is composed of a programmable controller and touching screen as the processing unit. The Schneider PLC TSX P57303 controller with its counterpart input/output modules is adopted as the hardware platform and the Schneider PL7-MICRO/WIN as the software platform. This paper presents the main flow process design of the control system. The test results show that the control system can run automatically and switch mutually under different modes, and the functions such as monitor and control over the environment parameters of the GLP laboratory are realized.

  11. Monitoring of physical health parameters for inpatients on a child and adolescent mental health unit receiving regular antipsychotic therapy.

    Science.gov (United States)

    Pasha, Nida; Saeed, Shoaib; Drewek, Katherine

    2015-01-01

    Physical health monitoring of patients receiving antipsychotics is vital. Overall it is estimated that individuals suffering with conditions like schizophrenia have a 20% shorter life expectancy than the average population, moreover antipsychotic use has been linked to a number of conditions including diabetes, obesity, and cardiovascular disease.[1-4] The severity of possible adverse effects to antipsychotics in adults has raised awareness of the importance of monitoring physical health in this population. However, there is little literature available as to the adverse effects of these medications in the child and adolescent community, which make physical health monitoring in this predominantly antipsychotic naïve population even more important. An expert group meeting in the UK has laid down recommendations in regards to screening and management of adult patients receiving antipsychotics, however no specific guidelines have been put in place for the child and adolescent age group.[5] The aim of this audit was to establish whether in-patients receiving antipsychotics had the following investigations pre-treatment and 12 weeks after treatment initiation: body mass index, hip-waist circumference, blood pressure, ECG, urea and electrolytes, full blood count, lipid profile, random glucose level, liver function test, and prolactin. This is in addition to a pre-treatment VTE risk assessment. These standards were derived from local trust guidelines, NICE guidelines on schizophrenia [6] and The Maudsley Prescribing Guidelines.[7] We retrospectively reviewed 39 electronic case notes in total, of which 24 cases were post intervention. Intervention included the use of a prompting tool. This tool was filed in the physical health files of all patients receiving antipsychotics which was intended as a reminder to doctors regarding their patient's need for physical health monitoring. Professionals involved in the monitoring of such parameters were educated in the importance and

  12. An all fiber-optic multi-parameter structure health monitoring system.

    Science.gov (United States)

    Hu, Chennan; Yu, Zhihao; Wang, Anbo

    2016-09-01

    In this work, we present an all fiber-optics based multi-parameter structure health monitoring system, which is able to monitor strain, temperature, crack and thickness of metal structures. This system is composed of two optical fibers, one for laser-acoustic excitation and the other for acoustic detection. A nano-second 1064 nm pulse laser was used for acoustic excitation and a 2 mm fiber Bragg grating was used to detect the acoustic vibration. The feasibility of this system was demonstrated on an aluminum test piece by the monitoring of the temperature, strain and thickness changes, as well as the appearance of an artificial crack. The multiplexing capability of this system was also preliminarily demonstrated.

  13. Circulating miRNA-155 is realted to blood pressure monitoring parameters

    Institute of Scientific and Technical Information of China (English)

    WU Ying; HUANG Yu-qing; HUANG Cheng; LI Jie; CAI An-ping; YU Xue-ju; ZHOU Dan

    2016-01-01

    Background Studies have shown that miRNA-155 played an important role in the process of development of hypertension.However,there is no date about miRNA-155 and blood pressure monitoring parameters.Therefore,we examined whether in hypertensive patients the expression level of plasma miRNA-155 related to 24-h ambulatory blood pressure monitoring (ABPM) parameters.Methods A cohort of adult patients scheduled to receive physical examination,office and ambulatory blood pressure monitoring.Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was used to evaluate the expression of selected miRNA-155.The miRNA-155 expression level correlation between blood pressure parameters was assessed using the Spearman correlation coefficient.Results Fifty four essential hypertension patients (25 men;mean age,53.28 ± 9.52 years) and thirty healthy volunteers (15 men;mean age,53.03 ± 5.87 years) were included.We observed higher expression level of miRNA-155 (32.31 ± 2.85 vs 27.21 ± 1.59,P < 0.001) in hypertensive patients compared to healthy control individuals.MiRNA-155 expression level showed significant positive correlation with 24 h Daytime SBP (r =0.681,P < 0.001),24 h Daytime DBP (r =0.473,P < 0.001),24 h Daytime PP (r =0.565,P < 0.001) and dipping (r =0.257,P =0.018),respectively.Conclusions Our study showed that miRNA-155 expression level was associated positively with daytime blood pressure monitoring parameters,as well as blood pressure variability,indicating a possible implication of miRNA-155 in the pathogenesis of hypertension.

  14. Pervasive health monitor and analysis based on multi-parameter smart armband.

    Science.gov (United States)

    Yang Yu; Qian Wang; Jing Liu

    2015-08-01

    With the growing attention on personal health, keeping track of the health related parameters has become an important issue, which is quite useful to increase people's living quality and reduce unpredicted risks. However, conventional physical checks are discrete and transient, which is incapable for the health monitor of daily living. Dedicated to everyday physiological monitor, we have developed a multi-parameter smart armband which is able record pulse, temperature and triaxial accelerations continuously. With the wearable device and signal processing algorithm, experiments of data acquisition in the daily living have been implemented on the volunteers. The long period record of 38 hours has demonstrated its feasibility of a total record without disturbing. And both historical and cross comparisons on the parameter correlation analysis have proven the valuable health information that the armband could reveal. As an integrated sensor module, the smart armband is simple and non-obtrusive, thus opens a promising approach towards the pervasive health monitor, especially for the elder population.

  15. [Hardware-software system for monitoring parameters and characteristics of X-ray computer tomographs under operation conditions].

    Science.gov (United States)

    Blinov, N N; Zelikman, M I; Kruchinin, S A

    2007-01-01

    The results of testing of hardware and software for monitoring parameters (mean number of CT units, noise, field uniformity, high-contrast spatial resolution, layer width, dose) and characteristics (modulation transfer function) of X-ray computer tomographs are presented. The developed hardware and software are used to monitor the stability of X-ray computer tomograph parameters under operation conditions.

  16. Theoretical analysis for the specific heat and thermal parameters of solid C60

    Science.gov (United States)

    Soto, J. R.; Calles, A.; Castro, J. J.

    1997-08-01

    We present the results of a theoretical analysis for the thermal parameters and phonon contribution to the specific heat in solid C60. The phonon contribution to the specific heat is calculated through the solution of the corresponding dynamical matrix, for different points in the Brillouin zone, and the construccion of the partial and generalized phonon density of states. The force constants are obtained from a first principle calculation, using a SCF Hartree-Fock wave function from the Gaussian 92 program. The thermal parameters reported are the effective temperatures and vibrational amplitudes as a function of temperature. Using this model we present a parametization scheme in order to reproduce the general behaviour of the experimental specific heat for these materials.

  17. Inter-observer agreement of a multi-parameter campsite monitoring program on the Dixie National Forest, Utah

    Science.gov (United States)

    Nicholas J. Glidden; Martha E. Lee

    2007-01-01

    Precision is crucial to campsite monitoring programs. Yet, little empirical research has ever been published on the level of precision of this type of monitoring programs. The purpose of this study was to evaluate the level of agreement between observers of campsite impacts using a multi-parameter campsite monitoring program. Thirteen trained observers assessed 16...

  18. Integral-based identification of patient specific parameters for a minimal cardiac model.

    Science.gov (United States)

    Hann, C E; Chase, J G; Shaw, G M

    2006-02-01

    A minimal cardiac model has been developed which accurately captures the essential dynamics of the cardiovascular system (CVS). However, identifying patient specific parameters with the limited measurements often available, hinders the clinical application of the model for diagnosis and therapy selection. This paper presents an integral-based parameter identification method for fast, accurate identification of patient specific parameters using limited measured data. The integral method turns a previously non-linear and non-convex optimization problem into a linear and convex identification problem. The model includes ventricular interaction and physiological valve dynamics. A healthy human state and four disease states, valvular stenosis, pulmonary embolism, cardiogenic shock and septic shock are used to test the method. Parameters for the healthy and disease states are accurately identified using only discretized flows into and out of the two cardiac chambers, the minimum and maximum volumes of the left and right ventricles, and the pressure waveforms through the aorta and pulmonary artery. These input values can be readily obtained non-invasively using echo-cardiography and ultra-sound, or invasively via catheters that are often used in Intensive Care. The method enables rapid identification of model parameters to match a particular patient condition in clinical real time (3-5 min) to within a mean value of 4-10% in the presence of 5-15% uniformly distributed measurement noise. The specific changes made to simulate each disease state are correctly identified in each case to within 10% without false identification of any other patient specific parameters. Clinically, the resulting patient specific model can then be used to assist medical staff in understanding, diagnosis and treatment selection.

  19. 40 CFR Appendix II to Part 1068 - Emission-Related Parameters and Specifications

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Emission-Related Parameters and Specifications II Appendix II to Part 1068 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS GENERAL COMPLIANCE PROVISIONS FOR ENGINE PROGRAMS Pt. 1068, App. II Appendix...

  20. Photoacoustic and photothermal cytometry for monitoring multiple blood rheology parameters in vivo

    Science.gov (United States)

    Galanzha, Ekaterina I.; Zharov, Vladimir P.

    2012-01-01

    Alterations of blood rheology (hemorheology) are important for the early diagnosis, prognosis, and prevention of many diseases, including myocardial infarction, stroke, sickle cell anemia, thromboembolism, trauma, inflammation, and malignancy. However, real-time in vivo monitoring of hemorheological status using multiple parameters over long periods of time has not been reported. Here we describe the capability of label-free photoacoustic (PA) and photothermal (PT) flow cytometry in detection and imaging modes for dynamic monitoring of rheological parameters in circulating blood. We show that this integrated platform can simultaneously measure the main rheological parameters and may improve their diagnostic value. Using phenomenological approaches, we analyze correlations of PT and PA signal characteristics in the dynamic modes with red blood cell (RBC) aggregation, deformability, shape (e.g., as in sickle cells), intracellular hemoglobin distribution, individual cell velocity, flux of RBCs, and likely shear rate. Proof of concept is demonstrated in ex vivo and in vivo tests, including high-speed PT imaging of RBC shape in pathological conditions and identification of sickle cells in a mouse model of human sickle cell disease. These studies revealed the potential of this new platform integrating PT, PA, and conventional optical techniques for translation to use in humans using safe, portable, laser-based medical devices for point-of-care screening of disease progression and therapy efficiency. PMID:21948731

  1. In vivo photoacoustic and photothermal cytometry for monitoring multiple blood rheology parameters.

    Science.gov (United States)

    Galanzha, Ekaterina I; Zharov, Vladimir P

    2011-10-01

    Alterations of blood rheology (hemorheology) are important for the early diagnosis, prognosis, and prevention of many diseases, including myocardial infarction, stroke, sickle cell anemia, thromboembolism, trauma, inflammation, and malignancy. However, real-time in vivo assessment of multiple hemorheological parameters over long periods of time has not been reported. Here, we review the capabilities of label-free photoacoustic (PA) and photothermal (PT) flow cytometry for dynamic monitoring of hemorhelogical parameters in vivo which we refer to as photoacoustic and photothermal blood rheology. Using phenomenological models, we analyze correlations between both PT and PA signal characteristics in the dynamic modes and following determinants of blood rheology: red blood cell (RBC) aggregation, deformability, shape (e.g., as in sickle cells), intracellular hemoglobin distribution, individual cell velocity, hematocrit, and likely shear rate. We present ex vivo and in vivo experimental verifications involving high-speed PT imaging of RBCs, identification of sickle cells in a mouse model of human sickle cell disease and in vivo monitoring of complex hemorheological changes (e.g., RBC deformability, hematocrit and RBC aggregation). The multi-parameter platform that integrates PT, PA, and conventional optical techniques has potential for translation to clinical applications using safe, portable, laser-based medical devices for point-of-care screening of disease progression and therapy efficiency.

  2. Specific Index Parameter Definition for Quantitative Evaluation of Electromagnetic Actuator Topologies

    Institute of Scientific and Technical Information of China (English)

    LOU Jie; ZHAO Xia; YUE Haifang; ZHANG Yuantao; LI Qingmin

    2013-01-01

    The fast electromagnetic drive mechanism based on fast switch shows extensive applications in many areas,hut there is still a lack of unified evaluation parameters as to evaluate the dynamic characteristics due to diversity and complexity of the mechanisms.Three interrelated evaluation parameters are presented for topology analysis,namely the electromagnetic force sensitivity coefficient,the initial time constant and the sensitivity contribution coefficient.The specific parameters based on evaluation can provide a basis for structural performance assessment as well as topology optimization.Comparison between the dynamic parameters of the discoid repulsion mechanism and the solenoid thrust mechanism shows that,the discoid one is superior to the solenoid one.The proposed research is to establish a general methodology for topology analysis and optimization of the electromagnetic mechanisms.

  3. On the validity of evolutionary models with site-specific parameters.

    Directory of Open Access Journals (Sweden)

    Konrad Scheffler

    Full Text Available Evolutionary models that make use of site-specific parameters have recently been criticized on the grounds that parameter estimates obtained under such models can be unreliable and lack theoretical guarantees of convergence. We present a simulation study providing empirical evidence that a simple version of the models in question does exhibit sensible convergence behavior and that additional taxa, despite not being independent of each other, lead to improved parameter estimates. Although it would be desirable to have theoretical guarantees of this, we argue that such guarantees would not be sufficient to justify the use of these models in practice. Instead, we emphasize the importance of taking the variance of parameter estimates into account rather than blindly trusting point estimates - this is standardly done by using the models to construct statistical hypothesis tests, which are then validated empirically via simulation studies.

  4. Recommendations on Fuel Parameters for Standard Technical Specifications for Spent Fuel Storage Casks

    Energy Technology Data Exchange (ETDEWEB)

    Bowman, S.M.

    2001-03-08

    The U.S. Nuclear Regulatory Commission (NRC) is currently reviewing the technical specifications for spent fuel storage casks in an effort to develop standard technical specifications (STS) that define the allowable spent nuclear fuel (SNF) contents. One of the objectives of the review is to minimize the level of detail in the STS that define the acceptable fuel types. To support this initiative, this study has been performed to identify potential fuel specification parameters needed for criticality safety and radiation shielding analysis and rank their importance relative to a potential compromise of the margin of safety.

  5. Application of basic and composite thrombelastography parameters in monitoring of the antithrombotic effect of the low molecular weight heparin dalteparin: an in vivo study

    DEFF Research Database (Denmark)

    Artang, Ramin; Frandsen, Niels J; Nielsen, Jørn Dalsgaard

    2009-01-01

    . At this point there are no point of care devices available in the market for monitoring the effect of LMWH. Thrombelastography (TEG) evaluates the viscoelastic properties of blood during coagulation. The clinical application of TEG in monitoring LMWH treatment is not yet well defined. The purpose...... volunteers (n = 7) were injected subcutaneously with the LMWH dalteparin 120 IU/kg. TEG parameters and antifactor Xa levels were measures at baseline, 2, 4, 5 and 24 hours after the injection. Correlation between TEG parameters and antiXa were calculated. The sensitivity and specificity of the TEG parameters...... of sensitivity and specificity for the therapeutic range of antiXa levels (r = 0.82, p

  6. A new topological parameter for monitoring subtle aggregation events in host-guest inclusion processes

    Science.gov (United States)

    Novato, Willian T. G.; De Almeida, Wagner B.; Dos Santos, Hélio F.

    2012-02-01

    Supramolecular complexes with cyclodextrin (CD) have been the subject of considerable research in the material and life sciences. The dynamics of systems are difficult to characterise, therefore, knowledge of the molecular features governing the host-guest equilibrium might aid in the design and practical application of the resulting inclusion complexes. In this Letter, we present a new topological parameter based on simple trigonometric considerations to be used to monitor subtle host-guest inclusion events along the molecular dynamics trajectory. The new topological descriptor, called vector-μ, was applied to amphetamine@α/β-CD inclusion complexes, providing interesting insights on the host-guest equilibrium.

  7. On the problem of monitoring the neutron parameters of the Fast Energy Amplifier

    Energy Technology Data Exchange (ETDEWEB)

    Behringer, K.; Wydler, P

    1998-10-01

    The conceptual Fast Energy Amplifier, proposed by Rubbia et al. (1995), consists of a combination of a U-233/Th-232 fuelled fast-neutron subcritical facility with a proton accelerator. An intense beam of 1 GeV protons is injected into liquid lead at the core centre and drives the reactor by producing spallation neutrons. The burst of spallation neutrons produced by a single proton alters the basic neutron statistics which are well known for thermal neutrons in conventional nuclear reactors. A short assessment of standard neutron noise analysis methods is made with respect to monitoring neutron parameter data. (author) 18 refs., 14 figs., 3 tabs.

  8. Parameter monitoring system of the Dubna Gas-Filled Recoil Separator

    CERN Document Server

    Tsyganov, Y S; Sukhov, A M

    2015-01-01

    PC-based one-crate monitoring and control system of the Dubna Gas Filled Recoil Separator (DGFRS) is considered. It is developed for the long-term experiments at the U400 FLNR cyclotron and is aimed at the synthesis of super heavy nuclei in heavy ion induced complete fusion reactions. Parameters related to: a) beam and cyclotron; b) separator by itself, c) detection system, d) target and entrance window are measured and stored in the protocol file of the experiment. Special attention is paid to generating the alarm signals and implementing further the appropriate procedures

  9. A low cost implementation of multi-parameter patient monitor using intersection kernel support vector machine classifier

    Science.gov (United States)

    Mohan, Dhanya; Kumar, C. Santhosh

    2016-03-01

    Predicting the physiological condition (normal/abnormal) of a patient is highly desirable to enhance the quality of health care. Multi-parameter patient monitors (MPMs) using heart rate, arterial blood pressure, respiration rate and oxygen saturation (S pO2) as input parameters were developed to monitor the condition of patients, with minimum human resource utilization. The Support vector machine (SVM), an advanced machine learning approach popularly used for classification and regression is used for the realization of MPMs. For making MPMs cost effective, we experiment on the hardware implementation of the MPM using support vector machine classifier. The training of the system is done using the matlab environment and the detection of the alarm/noalarm condition is implemented in hardware. We used different kernels for SVM classification and note that the best performance was obtained using intersection kernel SVM (IKSVM). The intersection kernel support vector machine classifier MPM has outperformed the best known MPM using radial basis function kernel by an absoute improvement of 2.74% in accuracy, 1.86% in sensitivity and 3.01% in specificity. The hardware model was developed based on the improved performance system using Verilog Hardware Description Language and was implemented on Altera cyclone-II development board.

  10. Patient-specific parameter estimation in single-ventricle lumped circulation models under uncertainty.

    Science.gov (United States)

    Schiavazzi, Daniele E; Baretta, Alessia; Pennati, Giancarlo; Hsia, Tain-Yen; Marsden, Alison L

    2017-03-01

    Computational models of cardiovascular physiology can inform clinical decision-making, providing a physically consistent framework to assess vascular pressures and flow distributions, and aiding in treatment planning. In particular, lumped parameter network (LPN) models that make an analogy to electrical circuits offer a fast and surprisingly realistic method to reproduce the circulatory physiology. The complexity of LPN models can vary significantly to account, for example, for cardiac and valve function, respiration, autoregulation, and time-dependent hemodynamics. More complex models provide insight into detailed physiological mechanisms, but their utility is maximized if one can quickly identify patient specific parameters. The clinical utility of LPN models with many parameters will be greatly enhanced by automated parameter identification, particularly if parameter tuning can match non-invasively obtained clinical data. We present a framework for automated tuning of 0D lumped model parameters to match clinical data. We demonstrate the utility of this framework through application to single ventricle pediatric patients with Norwood physiology. Through a combination of local identifiability, Bayesian estimation and maximum a posteriori simplex optimization, we show the ability to automatically determine physiologically consistent point estimates of the parameters and to quantify uncertainty induced by errors and assumptions in the collected clinical data. We show that multi-level estimation, that is, updating the parameter prior information through sub-model analysis, can lead to a significant reduction in the parameter marginal posterior variance. We first consider virtual patient conditions, with clinical targets generated through model solutions, and second application to a cohort of four single-ventricle patients with Norwood physiology. Copyright © 2016 John Wiley & Sons, Ltd.

  11. Ascertainment-adjusted parameter estimation approach to improve robustness against misspecification of health monitoring methods

    Science.gov (United States)

    Juesas, P.; Ramasso, E.

    2016-12-01

    Condition monitoring aims at ensuring system safety which is a fundamental requirement for industrial applications and that has become an inescapable social demand. This objective is attained by instrumenting the system and developing data analytics methods such as statistical models able to turn data into relevant knowledge. One difficulty is to be able to correctly estimate the parameters of those methods based on time-series data. This paper suggests the use of the Weighted Distribution Theory together with the Expectation-Maximization algorithm to improve parameter estimation in statistical models with latent variables with an application to health monotonic under uncertainty. The improvement of estimates is made possible by incorporating uncertain and possibly noisy prior knowledge on latent variables in a sound manner. The latent variables are exploited to build a degradation model of dynamical system represented as a sequence of discrete states. Examples on Gaussian Mixture Models, Hidden Markov Models (HMM) with discrete and continuous outputs are presented on both simulated data and benchmarks using the turbofan engine datasets. A focus on the application of a discrete HMM to health monitoring under uncertainty allows to emphasize the interest of the proposed approach in presence of different operating conditions and fault modes. It is shown that the proposed model depicts high robustness in presence of noisy and uncertain prior.

  12. Beer fermentation: monitoring of process parameters by FT-NIR and multivariate data analysis.

    Science.gov (United States)

    Grassi, Silvia; Amigo, José Manuel; Lyndgaard, Christian Bøge; Foschino, Roberto; Casiraghi, Ernestina

    2014-07-15

    This work investigates the capability of Fourier-Transform near infrared (FT-NIR) spectroscopy to monitor and assess process parameters in beer fermentation at different operative conditions. For this purpose, the fermentation of wort with two different yeast strains and at different temperatures was monitored for nine days by FT-NIR. To correlate the collected spectra with °Brix, pH and biomass, different multivariate data methodologies were applied. Principal component analysis (PCA), partial least squares (PLS) and locally weighted regression (LWR) were used to assess the relationship between FT-NIR spectra and the abovementioned process parameters that define the beer fermentation. The accuracy and robustness of the obtained results clearly show the suitability of FT-NIR spectroscopy, combined with multivariate data analysis, to be used as a quality control tool in the beer fermentation process. FT-NIR spectroscopy, when combined with LWR, demonstrates to be a perfectly suitable quantitative method to be implemented in the production of beer.

  13. Optimization of Operating Parameters for Minimum Mechanical Specific Energy in Drilling

    Energy Technology Data Exchange (ETDEWEB)

    Hamrick, Todd [West Virginia Univ., Morgantown, WV (United States)

    2011-01-01

    Efficiency in drilling is measured by Mechanical Specific Energy (MSE). MSE is the measure of the amount of energy input required to remove a unit volume of rock, expressed in units of energy input divided by volume removed. It can be expressed mathematically in terms of controllable parameters; Weight on Bit, Torque, Rate of Penetration, and RPM. It is well documented that minimizing MSE by optimizing controllable factors results in maximum Rate of Penetration. Current methods for computing MSE make it possible to minimize MSE in the field only through a trial-and-error process. This work makes it possible to compute the optimum drilling parameters that result in minimum MSE. The parameters that have been traditionally used to compute MSE are interdependent. Mathematical relationships between the parameters were established, and the conventional MSE equation was rewritten in terms of a single parameter, Weight on Bit, establishing a form that can be minimized mathematically. Once the optimum Weight on Bit was determined, the interdependent relationship that Weight on Bit has with Torque and Penetration per Revolution was used to determine optimum values for those parameters for a given drilling situation. The improved method was validated through laboratory experimentation and analysis of published data. Two rock types were subjected to four treatments each, and drilled in a controlled laboratory environment. The method was applied in each case, and the optimum parameters for minimum MSE were computed. The method demonstrated an accurate means to determine optimum drilling parameters of Weight on Bit, Torque, and Penetration per Revolution. A unique application of micro-cracking is also presented, which demonstrates that rock failure ahead of the bit is related to axial force more than to rotation speed.

  14. [Influence of treatment with olmesartan on ambulatory blood pressure monitoring parameters in patients with arterial hypertension].

    Science.gov (United States)

    Bregvadze, T R; Tseluĭko, V I; Mishchuk, N E

    2013-12-01

    Hypertension is the most common disease of the cardiovascular system. Active treatment of hypertension with adequate control of blood pressure (BP) can prevent complications, improve life quality and increase life expectancy. One of the interesting new antihypertensive agents, from the group of angiotensin receptor blockers is olmesartan. The obvious advantages of ambulatory blood pressure monitoring to traditional one-time measurements of BP make this method perspective for quality control of anti-hypertensive therapy. The aim of this study was to evaluate the influence of treatment with olmesartan on ambulatory blood pressure monitoring parameters in patients with hypertension. 38 out-patients with hypertension at the age of 25-84 years (mean 55,3±10,6) were studied. Patients received olmesartan 20 mg daily as monotherapy (20 patients (52,6%)) or in combination with other antihypertensive agents (18 patients (47,4%)). Treatment continued for 6 months. The complex examination included: measurement of office brachial BP, electrocardiography, echocardiography and ambulatory blood pressure monitoring (ABPM). As a result of treatment, office BP and diurnal BP, according to ABPM, significantly decreased; the favorable circadian BP profile dynamics were found: significantly less frequently observed lack of reduction in BP during night (daily index - non-dipper) - 18% vs. 64% (p treatment of hypertensive patients with olmesartan provides significant decline not only in office BP, but also in diurnal BP, normalizes BP of active and passive periods, also - daily index and reduces BP variability.

  15. Reactive and multiphase modelling for the identification of monitoring parameters to detect CO2 intrusion into freshwater aquifers

    Science.gov (United States)

    Fahrner, S.; Schaefer, D.; Wiegers, C.; Köber, R.; Dahmke, A.

    2011-12-01

    A monitoring at geological CO2 storage sites has to meet environmental, regulative, financial and public demands and thus has to enable the detection of CO2 leakages. Current monitoring concepts for the detection of CO2 intrusion into freshwater aquifers located above saline storage formations in course of leakage events lack the identification of monitoring parameters. Their response to CO2 intrusion still has to be enlightened. Scenario simulations of CO2 intrusion in virtual synthetic aquifers are performed using the simulators PhreeqC and TOUGH2 to reveal relevant CO2-water-mineral interactions and multiphase behaviour on potential monitoring parameters. The focus is set on pH, total dissolved inorganic carbon (TIC) and the hydroelectric conductivity (EC). The study aims at identifying at which conditions the parameters react rapidly, durable and in a measurable degree. The depth of the aquifer, the mineralogy, the intrusion rates, the sorption specification and capacities, and groundwater flow velocities are varied in the course of the scenario modelling. All three parameters have been found suited in most scenarios. However, in case of a lack of calcite combined with low saturation of the water with respect to CO2 and shallow conditions, changes are close to the measurement resolution. Predicted changes in EC result from the interplay between carbonic acid production and its dissociation, and pH buffering by mineral dissolution. The formation of a discrete gas phase in cases of full saturation of the groundwater in confined aquifers illustrates the potential bipartite resistivity response: An increased hydroelectric conductivity at locations with dissolved CO2, and a high resistivity where the gas phase dominates the pore volume occupation. Increased hydrostatic pressure with depth and enhanced groundwater flow velocities enforce gas dissolution and diminish the formation of a discrete gas phase. Based on the results, a monitoring strategy is proposed which

  16. Multi-parameter monitoring of a slow moving landslide in Gresten (Austria)

    Science.gov (United States)

    Canli, Ekrem; Thiebes, Benni; Engels, Alexander; Glade, Thomas; Schweigl, Joachim; Bertagnoli, Michael

    2015-04-01

    Landslides pose a major threat around the world, to both human life and infrastructure. This may be an even bigger issue in the near future, as an increased landslide activity is commonly listed as an expected impact of human-induced climate change, together with an increasing population growth and the further demand of living space. This requires sound and appropriate means of monitoring slopes prone to landsliding. Monitoring systems for investigating kinematic aspects of landslides aid in analyzing, interpreting, and ultimately understanding its spatio-temporal movement behavior. Landslides around the world greatly differ in terms of typology, movement patterns and geometry, thus, making it difficult to establish a one-fits-all monitoring solution. The linkage between multiple systems with automated instrumentation has often demonstrated the benefits of continuous surveillance in terms of predicting and early warning forthcoming landslide movements. Within this presentation, we introduce a recently established long-term monitoring site on the active Salcher landslide that makes use of an innovative multi-parameter system. The investigated landslide is situated in the municipality of Gresten (Austria) and extends over approx. 8000 m². This slow moving, deep-seated landslide is geologically located in the Gresten Klippenbelt (Helvetic Zone). The characteristic lithofacies are the Gresten Beds of Early Jurassic age that is covered by a sequence of marly and silty beds with intercalated sandy limestones. Together with the adjacent Flyschzone, this area exhibits one of the highest landslide susceptibility within Austria. The monitoring setup consists both of surface and subsurface systems. Surface measurements on multiple locations are performed with highly sensitive sensor networks that measure surface inclination and acceleration. These are wirelessly connected with each other, highly flexible and constructed with a high longevity, yet still at a high measurement

  17. Parameter Optimization of Information Channels for Laser Fluorescence Method of Vegetation Monitoring

    Directory of Open Access Journals (Sweden)

    M. L. Belov

    2015-01-01

    Full Text Available Nowadays, there is a growing interest in application of remote monitoring and accounting systems in agriculture.One of the promising areas of remote vegetation monitoring is a fluorescence analysis, as it potentially allows sensing stress of plants according to characteristics of their fluorescent radiation.The shape of the fluorescence spectra of vegetation in the normal condition differs from that of the fluorescence spectra of vegetation in stressful conditions. This potentially allows you to sence the plants by recording information about the shape of the fluorescence spectra.Analysis of the fluorescence spectrum shape can be replaced by the analysis of fluorescence intensities in several spectral bands, which simpifies problem-solving.Currently, there are various devices developed for laser fluorescence sensing of plant stress. However, a lot of issues important to the practice remain unclear.Most of these issues concern the parameters of receiving channels to record information signals, which allow you to perceve the stress-sensed plants:- how many information channels of spectral bands better to use;- what the best width of these spectral bands of information is ;- what is the best width of the spectral bands of information;- what the best threshold value for the threshold algorithm is, and if there is the better algorithm to process measurement data.The work uses mathematical modeling based on the experimentally measured fluorescence spectra to determine the optimal (in terms of probability of sensing characteristics of the stress of plants, i.e. the probability of good sense and false alarm parameters of information channels for laser fluorescence method to sense the plant stress: the central wavelength of the information spectral bands, their spectral width, and parameters of the algorithm in the case of processing two spectral channels of information. It is shown that using the additional third information spectral band allows you to

  18. Using continuous monitoring of physical parameters to better estimate phosphorus fluxes in a small agricultural catchment

    Science.gov (United States)

    Minaudo, Camille; Dupas, Rémi; Moatar, Florentina; Gascuel-Odoux, Chantal

    2016-04-01

    Phosphorus fluxes in streams are subjected to high temporal variations, questioning the relevance of the monitoring strategies (generally monthly sampling) chosen to assist EU Directives to capture phosphorus fluxes and their variations over time. The objective of this study was to estimate the annual and seasonal P flux uncertainties depending on several monitoring strategies, with varying sampling frequencies, but also taking into account simultaneous and continuous time-series of parameters such as turbidity, conductivity, groundwater level and precipitation. Total Phosphorus (TP), Soluble Reactive Phosphorus (SRP) and Total Suspended Solids (TSS) concentrations were surveyed at a fine temporal frequency between 2007 and 2015 at the outlet of a small agricultural catchment in Brittany (Naizin, 5 km2). Sampling occurred every 3 to 6 days between 2007 and 2012 and daily between 2013 and 2015. Additionally, 61 storms were intensively surveyed (1 sample every 30 minutes) since 2007. Besides, water discharge, turbidity, conductivity, groundwater level and precipitation were monitored on a sub-hourly basis. A strong temporal decoupling between SRP and particulate P (PP) was found (Dupas et al., 2015). The phosphorus-discharge relationships displayed two types of hysteretic patterns (clockwise and counterclockwise). For both cases, time-series of PP and SRP were estimated continuously for the whole period using an empirical model linking P concentrations with the hydrological and physic-chemical variables. The associated errors of the estimated P concentrations were also assessed. These « synthetic » PP and SRP time-series allowed us to discuss the most efficient monitoring strategies, first taking into account different sampling strategies based on Monte Carlo random simulations, and then adding the information from continuous data such as turbidity, conductivity and groundwater depth based on empirical modelling. Dupas et al., (2015, Distinct export dynamics for

  19. Formal specification and animation of a water level monitoring system. Research report No. INFO-0428

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, P.S.; Stokes, P.A.

    1993-01-01

    This report describes the Vienna Development Method (VDM), a formal method for software specification and development, and its use for a real-time application where it is used to formally specify the requirements of a water level monitoring system. The procedure and techniques used to produce an executable form (animation) of the specification are covered.

  20. Investigating the value of passive microwave observations for monitoring volcanic eruption source parameters

    Science.gov (United States)

    Montopoli, Mario; Cimini, Domenico; Marzano, Frank

    2016-04-01

    Volcanic eruptions inject both gas and solid particles into the Atmosphere. Solid particles are made by mineral fragments of different sizes (from few microns to meters), generally referred as tephra. Tephra from volcanic eruptions has enormous impacts on social and economical activities through the effects on the environment, climate, public health, and air traffic. The size, density and shape of a particle determine its fall velocity and thus residence time in the Atmosphere. Larger particles tend to fall quickly in the proximity of the volcano, while smaller particles may remain suspended for several days and thus may be transported by winds for thousands of km. Thus, the impact of such hazards involves local as well as large scales effects. Local effects involve mostly the large sized particles, while large scale effects are caused by the transport of the finest ejected tephra (ash) through the atmosphere. Forecasts of ash paths in the atmosphere are routinely run after eruptions using dispersion models. These models make use of meteorological and volcanic source parameters. The former are usually available as output of numerical weather prediction models or large scale reanalysis. Source parameters characterize the volcanic eruption near the vent; these are mainly the ash mass concentration along the vertical column and the top altitude of the volcanic plume, which is strictly related to the flux of the mass ejected at the emission source. These parameters should be known accurately and continuously; otherwise, strong hypothesis are usually needed, leading to large uncertainty in the dispersion forecasts. However, direct observations during an eruption are typically dangerous and impractical. Thus, satellite remote sensing is often exploited to monitor volcanic emissions, using visible (VIS) and infrared (IR) channels available on both Low Earth Orbit (LEO) and Geostationary Earth Orbit (GEO) satellites. VIS and IR satellite imagery are very useful to monitor

  1. Drought monitoring over the Horn of Africa using remotely sensed evapotranspiration, soil moisture and vegetation parameters

    Science.gov (United States)

    Timmermans, J.; Gokmen, M.; Eden, U.; Abou Ali, M.; Vekerdy, Z.; Su, Z.

    2012-04-01

    The need to good drought monitoring and management for the Horn of Africa has never been greater. This ongoing drought is the largest in the past sixty years and is effecting the life of around 10 million people, according to the United Nations. The impact of drought is most apparent in food security and health. In addition secondary problems arise related to the drought such as large migration; more than 15000 Somalia have fled to neighboring countries to escape the problems caused by the drought. These problems will only grow in the future to larger areas due to increase in extreme weather patterns due to global climate change. Monitoring drought impact and managing the drought effects are therefore of critical importance. The impact of a drought is hard to characterize as drought depends on several parameters, like precipitation, land use, irrigation. Consequently the effects of the drought vary spatially and range from short-term to long-term. For this reason a drought event can be characterized into four categories: meteorological, agricultural, hydrological and socio-economical. In terms of food production the agricultural drought, or short term dryness near the surface layer, is most important. This drought is usually characterized by low soil moisture content in the root zone, decreased evapotranspiration, and changes in vegetation vigor. All of these parameters can be detected with good accuracy from space. The advantage of remote sensing in Drought monitoring is evident. Drought monitoring is usually performed using drought indices, like the Palmer Index (PDSI), Crop Moisture Index (CMI), Standard Precipitation Index (SPI). With the introduction of remote sensing several indices of these have shown great potential for large scale application. These indices however all incorporate precipitation as the main surface parameter neglecting the response of the surface to the dryness. More recently two agricultural drought indices, the EvapoTranspiration Deficit

  2. Spectral Induced Polarization monitoring of the groundwater physico-chemical parameters daily variations for stream-groundwater interactions

    Science.gov (United States)

    Jougnot, Damien; Camerlynck, Christian; Robain, Henri; Tallec, Gaëlle; Ribolzi, Olivier; Gaillardet, Jérôme

    2017-04-01

    During the last decades, geophysical methods have been attracting an increasing interest in hydrology and environmental sciences given their sensitivity to parameters of interests and their non-intrusive nature. The Spectral Induced Polarization (SIP) is a low frequency electro-magnetic method that allows the characterization of the subsurface through its complex electrical conductivity. It reports the modulus of the conductivity and the phase between an injected current and a measured voltage over a rather large frequency range (from few millihertz to few tens of kilohertz). The real part of the conductivity is sensitive to lithological (porosity, specific surface area) and hydrological (water saturation, water salinity) parameters, while the imaginary part is linked to electrochemical polarizations, that have been shown to be largely influenced by the chemistry of the pore water. In the present contribution, we aim at better characterizing the exchanges between a stream and the surrounding groundwater using the SIP method and its sensitivity to pore water changes over time. Two sites from the OZCAR Research Infrastructure (French Critical Zone observatories) have been chosen for this study: the Houay Pano catchment (Laos) and the Orgeval catchment (France). These two sites have a good existing infrastructure and have been already studied extensively in terms of hydrology, geophysics, and hydrochemistry. They constitute perfect experimental sites to develop novel methodologies for the assessment of stream-groundwater exchanges. We propose to obtain a vertical description of the changes in complex electrical conductivity with depth based on SIP soundings undertaken with the multi-channel system SIP Fuchs III. We conducted a high-frequency monitoring close to a river stream (one vertical profiles every 30 min). In parallel, a high frequency monitoring of the physico-chemical parameters (temperature, conductivity, ionic concentrations) in the river stream has been

  3. Universal computer vision system for monitoring the main parameters of wind turbines

    Directory of Open Access Journals (Sweden)

    Korzhavin Sergey

    2016-01-01

    Full Text Available The article presents universal autonomous system of computer vision to monitor the operation of wind turbines. The proposed system allows to estimate the rotational speed and the relative position deviation of the wind turbine. We present a universal method for determining the rotation of wind turbines of various shapes and structures. All obtained data are saved in the database. The presented method was tested at the Territory of Non-traditional Renewable Energy Sources of Ural Federal University Experimental wind turbines is produced by “Scientific and Production Association of automatics named after academician N.A. Semikhatov”. Results show the efficiency of the proposed system and the ability to determine main parameters such as the rotational speed, accuracy and quickness of orientation. The proposed solution is to assume that, in most cases a rotating and central parts of the wind turbine can be allocated different color. The color change of wind blade should not affect the system performance.

  4. The safety parameters monitoring system for the coal mine based on CAN bus communication and intelligent data acquisition

    Institute of Scientific and Technical Information of China (English)

    Bin Guangfu; Chu Wangwen; Balbir S.Dhillon; He Wenbiao

    2008-01-01

    In this paper,a monitoring and controlling system for the safety in production and environmental parameters of a small and medium-sized coal mine has been developed after analyzing the current domestic coal production and securi-ty conditions.The client computer can convert the analog signal about the safety in production and environmental param-eters detected from the monitoring terminal into digital signal,and then,send the signal to the coal mine safety monito-ring centre.This information can be analyzed,judged,and diagnosed by the monitoring-management-controUing soft-ware for helping the manager and technical workers to control the actual underground production and security situations.The system has many advantages including high reliability,better performance of real-time monitoring,faster data com-municating and good practicability,and it can effectively prevent the occurrence of safety incidents in coal mines.

  5. Changes in Predicted Muscle Coordination with Subject-Specific Muscle Parameters for Individuals after Stroke

    Directory of Open Access Journals (Sweden)

    Brian A. Knarr

    2014-01-01

    Full Text Available Muscle weakness is commonly seen in individuals after stroke, characterized by lower forces during a maximal volitional contraction. Accurate quantification of muscle weakness is paramount when evaluating individual performance and response to after stroke rehabilitation. The objective of this study was to examine the effect of subject-specific muscle force and activation deficits on predicted muscle coordination when using musculoskeletal models for individuals after stroke. Maximum force generating ability and central activation ratio of the paretic plantar flexors, dorsiflexors, and quadriceps muscle groups were obtained using burst superimposition for four individuals after stroke with a range of walking speeds. Two models were created per subject: one with generic and one with subject-specific activation and maximum isometric force parameters. The inclusion of subject-specific muscle data resulted in changes in the model-predicted muscle forces and activations which agree with previously reported compensation patterns and match more closely the timing of electromyography for the plantar flexor and hamstring muscles. This was the first study to create musculoskeletal simulations of individuals after stroke with subject-specific muscle force and activation data. The results of this study suggest that subject-specific muscle force and activation data enhance the ability of musculoskeletal simulations to accurately predict muscle coordination in individuals after stroke.

  6. Are subject-specific musculoskeletal models robust to the uncertainties in parameter identification?

    Directory of Open Access Journals (Sweden)

    Giordano Valente

    Full Text Available Subject-specific musculoskeletal modeling can be applied to study musculoskeletal disorders, allowing inclusion of personalized anatomy and properties. Independent of the tools used for model creation, there are unavoidable uncertainties associated with parameter identification, whose effect on model predictions is still not fully understood. The aim of the present study was to analyze the sensitivity of subject-specific model predictions (i.e., joint angles, joint moments, muscle and joint contact forces during walking to the uncertainties in the identification of body landmark positions, maximum muscle tension and musculotendon geometry. To this aim, we created an MRI-based musculoskeletal model of the lower limbs, defined as a 7-segment, 10-degree-of-freedom articulated linkage, actuated by 84 musculotendon units. We then performed a Monte-Carlo probabilistic analysis perturbing model parameters according to their uncertainty, and solving a typical inverse dynamics and static optimization problem using 500 models that included the different sets of perturbed variable values. Model creation and gait simulations were performed by using freely available software that we developed to standardize the process of model creation, integrate with OpenSim and create probabilistic simulations of movement. The uncertainties in input variables had a moderate effect on model predictions, as muscle and joint contact forces showed maximum standard deviation of 0.3 times body-weight and maximum range of 2.1 times body-weight. In addition, the output variables significantly correlated with few input variables (up to 7 out of 312 across the gait cycle, including the geometry definition of larger muscles and the maximum muscle tension in limited gait portions. Although we found subject-specific models not markedly sensitive to parameter identification, researchers should be aware of the model precision in relation to the intended application. In fact, force

  7. [Monitoring of the Moskva River Water Using Microbiological Parameters and Chlorophyll a Fluorescence].

    Science.gov (United States)

    Mosharova, I V; Il'inskii, V V; Matorin, D N; Mosharov, S A; Akulova, A Yu; Protopopov, F F

    2015-01-01

    The results of investigations of three Moskva River sites with different degree of pollution using a complex of microbiological characteristics and the parameters of chlorophyll a fluorescence are presented. We determined that the bacterioplankton seasonal dynamics at less polluted waters (Tushino and Vorobyovy Gory) were similar and differed significantly from one in more polluted waters (Dzerzhinskii). The number of bacteria with active electron transport chain, as well as their share in the bacterioplankton structure, was higher in the water of Dzerzhinskii (average annual values of 0.23 x 10(6) cells/mL and 14%), that in the less polluted water of Tushino and Vorobyovy Gory (0.14 x 10(6) cells/mL; 6% and 0.15 x 10(6) cells/mL; 7%, respectively). From April to October, the content of chlorophyll a and its photosynthetic activity were the highest in Tushino. In Dzerzhinskii, during spring the increase in photosynthetic activity commenced earlier and was more intensive that the increase in chlorophyll a content, i.e., the increase in phytoplankton biomass was temporarily suppressed. We suggest association of this phenomenon with suppression of organic matter synthesis by phytoplankton due to the high water pollution in Dzerzhinskii. The second autumn peak of chlorophyll a content, that was typical of clear water and was observed in Tushino, did not occur in Dzerzhinskii. We recommend combined application of these microbiological parameters and characteristics of chlorophyll a fluorescence for a monitoring.

  8. Diffusion tensor imaging of the human calf: Variation of inter- and intramuscle-specific diffusion parameters.

    Science.gov (United States)

    Schlaffke, Lara; Rehmann, Robert; Froeling, Martijn; Kley, Rudolf; Tegenthoff, Martin; Vorgerd, Matthias; Schmidt-Wilcke, Tobias

    2017-10-01

    To investigate to what extent inter- and intramuscular variations of diffusion parameters of human calf muscles can be explained by age, gender, muscle location, and body mass index (BMI) in a specific age group (20-35 years). Whole calf muscles of 18 healthy volunteers were evaluated. Magnetic resonance imaging (MRI) was performed using a 3T scanner and a 16-channel Torso XL coil. Diffusion-weighted images were acquired to perform fiber tractography and diffusion tensor imaging (DTI) analysis for each muscle of both legs. Fiber tractography was used to separate seven lower leg muscles. Associations between DTI parameters and confounds were evaluated. All muscles were additionally separated in seven identical segments along the z-axis to evaluate intramuscular differences in diffusion parameters. Fractional anisotropy (FA) and mean diffusivity (MD) were obtained for each muscle with low standard deviations (SDs) (SDFA : 0.01-0.02; SDMD : 0.07-0.14(10(-3) )). We found significant differences in FA values of the tibialis anterior muscle (AT) and extensor digitorum longus (EDL) muscles between men and women for whole muscle FA (two-sample t-tests; AT: P = 0.0014; EDL: P = 0.0004). We showed significant intramuscular differences in diffusion parameters between adjacent segments in most calf muscles (P muscle insertions showed higher (SD 0.03-0.06) than muscle bellies (SD 0.01-0.03), no relationships between FA or MD with age or BMI were found. Inter- and intramuscular variations in diffusion parameters of the calf were shown, which are not related to age or BMI in this age group. Differences between muscle belly and insertion should be considered when interpreting datasets not including whole muscles. 3 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2017;46:1137-1148. © 2017 International Society for Magnetic Resonance in Medicine.

  9. [Inducible specific lux-biosensors for the detection of antibiotics: construction and main parameters].

    Science.gov (United States)

    Kotova, V Iu; Ryzhenkova, K V; Manukhov, I V; Zavil'gel'skiĭ, G B

    2014-01-01

    Based on Escherichia coli, highly sensitive specific lux-biosensors for the detection of tetracycline and beta-lactam antibiotics, quinolones, and aminoglycosides have been obtained. To make biosensors, bacteria were used that contained fungal plasmids pTetA'::lux, pAmpC'::lux, pColD'::lux, and plbpA'::lux, in which transcription of the reporter Photorhabdus luminescens luxCDABE genes occurred from the inducible promoters of the tetA, ampC, cda, and ibpA genes, respectively. The main parameters (threshold sensitivity and response time) of lux-biosensors were measured. The high specificity of biosensors responding only to antibiotics of a certain type was demonstrated.

  10. Research on Application of Perceived QoS Guarantee through Infrastructure Specific Traffic Parameter Optimization

    Directory of Open Access Journals (Sweden)

    Vikram Jeet Singh

    2014-02-01

    Full Text Available The technological developments in the fields of multimedia clinical applications and communication networks require a specific analysis to increase the efficiency of network based healthcare services. In this work, we computed the optimum transmission parameter (data packet size for applications needed to guarantee the perceived quality of service in the proposed ubiquitous healthcare network. This has been carried out through NS2 based simulation of a state wide area network infrastructure implemented in Himachal Pradesh, a state with diverse geographical terrain situated in the Western Himalayan region of India. The various types of healthcare applications and services have been classified into different classes according to their perceived QOS requirements as per the guidelines in ITU report on network performance objectives. The infrastructure specific optimum values of data packet size for these QoS classes have been computed. Network based healthcare applications and services running on both TCP and UDP type of traffic have been presented in this paper.

  11. 40 CFR 75.71 - Specific provisions for monitoring NOX and heat input for the purpose of calculating NOX mass...

    Science.gov (United States)

    2010-07-01

    ... MONITORING NOX Mass Emissions Provisions § 75.71 Specific provisions for monitoring NOX and heat input for... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Specific provisions for monitoring NOX and heat input for the purpose of calculating NOX mass emissions. 75.71 Section 75.71 Protection...

  12. SITE SPECIFIC REFERENCE PERSON PARAMETERS AND DERIVED CONCENTRATION STANDARDS FOR THE SAVANNAH RIVER SITE

    Energy Technology Data Exchange (ETDEWEB)

    Jannik, T.

    2013-03-14

    The purpose of this report is twofold. The first is to develop a set of behavioral parameters for a reference person specific for the Savannah River Site (SRS) such that the parameters can be used to determine dose to members of the public in compliance with Department of Energy (DOE) Order 458.1 “Radiation Protection of the Public and the Environment.” A reference person is a hypothetical, gender and age aggregation of human physical and physiological characteristics arrived at by international consensus for the purpose of standardizing radiation dose calculations. DOE O 458.1 states that compliance with the annual dose limit of 100 mrem (1 mSv) to a member of the public may be demonstrated by calculating the dose to the maximally exposed individual (MEI) or to a representative person. Historically, for dose compliance, SRS has used the MEI concept, which uses adult dose coefficients and adult male usage parameters. Beginning with the 2012 annual site environmental report, SRS will be using the representative person concept for dose compliance. The dose to a representative person will be based on 1) the SRS-specific reference person usage parameters at the 95th percentile of appropriate national or regional data, which are documented in this report, 2) the reference person (gender and age averaged) ingestion and inhalation dose coefficients provided in DOE Derived Concentration Technical Standard (DOE-STD-1196-2011), and 3) the external dose coefficients provided in the DC_PAK3 toolbox. The second purpose of this report is to develop SRS-specific derived concentration standards (DCSs) for all applicable food ingestion pathways, ground shine, and water submersion. The DCS is the concentration of a particular radionuclide in water, in air, or on the ground that results in a member of the public receiving 100 mrem (1 mSv) effective dose following continuous exposure for one year. In DOE-STD-1196-2011, DCSs were developed for the ingestion of water, inhalation of

  13. Water Channels Are Involved in Stomatal Oscillations Encoded by Parameter-Specific Cytosolic Calcium Oscillations

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Earlier studies have shown that various stimuli can induce specific cytosolic calcium ([Ca2+]cyt) oscillations in guard cells and various oscillations in stomatal apertures. Exactly how [Ca2+]cyt oscillation signaling functions in stomatal oscillation is not known. In the present study, the epidermis of broad bean (Vicia faba L.)was used and a rapid ion-exchange treatment with two shifting buffers differing in K+ and Ca2+ concentrations was applied. The treatment for five transients at a 10-min transient period induced clear and regular stomatal oscillation. However, for other transient numbers and periods, the treatments induced some irregular oscillations or even no obvious oscillations in stomatal aperture. The results indicate that stomatal oscillation is encoded by parameter-specific [Ca2+]cyt oscillation: the parameters of [Ca2+]cyt oscillation affected the occurrence rate and the parameters of stomatal oscillation. The water channel inhibitor HgCl2 completely inhibited stomatal oscillation and the inhibitory effect could be partially reversed by β-mercaptoethanol (an agent capable of reversing water channel inhibition by HgCl2). Other inhibitory treatments against ion transport (i.e. the application of LaCl3, EGTA, or tetraethylammonium chloride (TEACl))weakly impaired stomatal oscillation when the compounds were added after rapid ion-exchange treatment.If these compounds were added before rapid-ion exchange treatment, the inhibitory effect was much more apparent (except in the case of TEACI). The results of the present study suggest that water channels are involved in stomatal oscillation as a downstream element of [Ca2+]cyt oscillation signaling.

  14. Benefit of general anesthesia monitored by bispectral index compared with monitoring guided only by clinical parameters. Systematic review and meta-analysis.

    Science.gov (United States)

    Oliveira, Carlos Rogério Degrandi; Bernardo, Wanderley Marques; Nunes, Victor Moisés

    The bispectral index parameter is used to guide the titration of general anesthesia; however, many studies have shown conflicting results regarding the benefits of bispectral index monitoring. The objective of this systematic review with meta-analysis is to evaluate the clinical impact of monitoring with the bispectral index parameter. The search for evidence in scientific information sources was conducted during December 2013 to January 2015, the following primary databases: Medline/PubMed, LILACS, Cochrane, CINAHL, Ovid, SCOPUS and TESES. The criteria for inclusion in the study were randomized controlled trials, comparing general anesthesia monitored, with bispectral index parameter with anesthesia guided solely by clinical parameters, and patients aged over 18 years. The criteria for exclusion were studies involving anesthesia or sedation for diagnostic procedures, and intraoperative wake-up test for surgery of the spine. The use of monitoring with the bispectral index has shown benefits reducing time to extubation, orientation in time and place, and discharge from both the operating room and post anesthetic care unit. The risk of nausea and vomiting after surgery was reduced by 12% in patients monitored with bispectral index. Occurred a reduction of 3% in the risk of cognitive impairment postoperatively at 3 months postoperatively and 6% reduction in the risk of postoperative delirium in patients monitored with bispectral index. Furthermore, the risk of intraoperative memory has been reduced by 1%. Clinically, anesthesia monitoring with the BIS can be justified because it allows advantages from reducing the recovery time after waking, mainly by reducing the administration of general anesthetics as well as the risk of adverse events. Copyright © 2016 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

  15. [Benefit of general anesthesia monitored by bispectral index compared with monitoring guided only by clinical parameters. Systematic review and meta-analysis].

    Science.gov (United States)

    Oliveira, Carlos Rogério Degrandi; Bernardo, Wanderley Marques; Nunes, Victor Moisés

    The bispectral index parameter is used to guide the titration of general anesthesia; however, many studies have shown conflicting results regarding the benefits of bispectral index monitoring. The objective of this systematic review with meta-analysis is to evaluate the clinical impact of monitoring with the bispectral index parameter. The search for evidence in scientific information sources was conducted during December 2013 to January 2015, the following primary databases: Medline/PubMed, LILACS, Cochrane, CINAHL, Ovid, SCOPUS and TESES. The criteria for inclusion in the study were randomized controlled trials, comparing general anesthesia monitored, with bispectral index parameter with anesthesia guided solely by clinical parameters, and patients aged over 18 years. The criteria for exclusion were studies involving anesthesia or sedation for diagnostic procedures, and intraoperative wake-up test for surgery of the spine. The use of monitoring with the bispectral index has shown benefits reducing time to extubation, orientation in time and place, and discharge from both the operating room and post anesthetic care unit. The risk of nausea and vomiting after surgery was reduced by 12% in patients monitored with bispectral index. Occurred a reduction of 3% in the risk of cognitive impairment postoperatively at 3 months postoperatively and 6% reduction in the risk of postoperative delirium in patients monitored with bispectral index. Furthermore, the risk of intraoperative memory has been reduced by 1%. Clinically, anesthesia monitoring with the BIS can be justified because it allows advantages from reducing the recovery time after waking, mainly by reducing the administration of general anesthetics as well as the risk of adverse events. Copyright © 2016 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.

  16. [Multi-bed & multi-parameter central monitoring system based on TCP/IP protocol].

    Science.gov (United States)

    Lian, S J; Hu, D K; Zhao, M H; Tang, L H

    2000-02-01

    Communication is one of the key problems to a central monitoring system. In this paper we put forward a central monitoring system using TCP/IP as the network protocol, Windows NT4.0 as the platform, forming a Intranet in a hospital. We also discussed the communication problem between the bed-side monitoring station and the central monitoring station in detail and then put forward a new protocol--Hospital Central Monitor Protocol (HCMP) based on TCP/IP to transfer monitoring data. It is easy to achieve tele-monitoring through the current communication subsystem.

  17. Scanning laser polarimetry: »number« parameter sensitivity and specificity in glaucoma diagnostics

    Directory of Open Access Journals (Sweden)

    Barbara Cvenkel

    2005-10-01

    Full Text Available Background: Scanning laser polarimetry (SLP is a method that enables quantitative assessment of retinal nerve fibre layer (RNFL thickness surrounding the optic nerve. The commercially available device GDx (GDx, Laser Diagnostics Technologies, San Diego, CA yields an outprint consisting of a reflectance image, colour-coded retardation map, and the 14 parameters, of which the »Number« was shown to be the single best parameter to discriminate between glaucomatous and normal eyes. The »Number« is a probability score, ranging from 1 (low probability of glaucoma to 100 (high probability of glaucoma. In our study we determined the sensitivity and the specificity of the »Number« at cutoff values of 23 and 30. Methods: Thirty patients with different stage of glaucoma and 14 patients with typical glaucomatous changes of the ONH without visual field loss (preperimetric glaucoma were included in the analysis. The control group was represented by 27 adults without ocular pathology with intraocular pressure of < 21 mmHg and normal visual fields. The sensitivity and specificity of the »Number« was determined at a cut-off level of 23 and 30. Results: The sensitivity of the »Number« at a cut-off level of 30 for the glaucoma group was 74% at a specificity of 86%, at a cut-off of 23 the sensitivity increased to 83% at a specificity of 76%. The discriminating ability of the »Number« in the group with preperimetric glaucoma was low, with the sensitivities of 36% and 50% at a cut-off value of 30 and 23, respectively.Conclusions: The parameter »Number« yielded good separation between normal eyes and eyes with moderate and advanced glaucoma. However, the sensitivity of the »Number« in eyes with mild glaucoma and especially with preperimetric glaucoma was low. Because of the great interindividual variability of the RNFL, the assessment of RNFL thickness change over time would be more appropriate to detect early glaucomatous changes.

  18. Choroidal Vascularity Index (CVI--A Novel Optical Coherence Tomography Parameter for Monitoring Patients with Panuveitis?

    Directory of Open Access Journals (Sweden)

    Rupesh Agrawal

    Full Text Available To compute choroidal vascularity index (CVI using an image binarization tool on enhanced depth imaging (EDI-optical coherence tomography (OCT scans as a non-invasive optical tool to monitor progression in panuveitis and to investigate the utility of volumetric data from EDI-OCT scans using custom image analysis software.In this retrospective cohort study, segmented EDI-OCT scans of both eyes in 19 patients with panuveitis were taken at baseline and at 3-month follow-up and were compared with EDI-OCT scans of normal eyes. Subfoveal choroidal area was segmented into luminal (LA and stromal interstitial area (SA. Choroidal vascularity index (CVI was defined as the proportion of LA to the total circumscribed subfoveal choroidal area (TCA.The mean choroidal thickness was 265.5±100.1μm at baseline and 278.4±102.6μm at 3 months follow up (p = 0.06. There was no statistically significant difference in TCA between study and control eyes (p = 0.08. CVI in the control group was 66.9±1.5% at baseline and 66.4±1.5% at follow up. CVI was 74.1±4.7% at baseline and 69.4±4.8% at 3 months follow up for uveitic eyes (p<0.001. The % change in CVI was 6.2 ±3.8 (4.3 to 8.0 for uveitic eyes, which was significantly higher from % change in CVI for control eyes (0.7±1.1, 0.2 to 1.3, p<0.001.The study reports composite OCT-derived parameters and CVI as a possible novel tool in monitoring progression in panuveitis. CVI may be further validated in larger studies as a novel optical tool to quantify choroidal vascular status.

  19. Progress report:Specifications and design criteria for innovative corrosion monitoring and (downhole) sensor systems

    NARCIS (Netherlands)

    Zhang, X.; Akemu, A.

    2010-01-01

    The objective of this sub-project is to establish specifications and design criteria for corrosion monitoring and corrosion sensor systems used in CO2 storage wells; this includes sensitivity analysis and an evaluation of technological maturity. In the Year 1 programme, we review the tools deployed

  20. Distributed Dynamic State Estimator, Generator Parameter Estimation and Stability Monitoring Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Meliopoulos, Sakis [Georgia Inst. of Technology, Atlanta, GA (United States); Cokkinides, George [Georgia Inst. of Technology, Atlanta, GA (United States); Fardanesh, Bruce [New York Power Authority, NY (United States); Hedrington, Clinton [U.S. Virgin Islands Water and Power Authority (WAPA), St. Croix (U.S. Virgin Islands)

    2013-12-31

    This is the final report for this project that was performed in the period: October1, 2009 to June 30, 2013. In this project, a fully distributed high-fidelity dynamic state estimator (DSE) that continuously tracks the real time dynamic model of a wide area system with update rates better than 60 times per second is achieved. The proposed technology is based on GPS-synchronized measurements but also utilizes data from all available Intelligent Electronic Devices in the system (numerical relays, digital fault recorders, digital meters, etc.). The distributed state estimator provides the real time model of the system not only the voltage phasors. The proposed system provides the infrastructure for a variety of applications and two very important applications (a) a high fidelity generating unit parameters estimation and (b) an energy function based transient stability monitoring of a wide area electric power system with predictive capability. Also the dynamic distributed state estimation results are stored (the storage scheme includes data and coincidental model) enabling an automatic reconstruction and “play back” of a system wide disturbance. This approach enables complete play back capability with fidelity equal to that of real time with the advantage of “playing back” at a user selected speed. The proposed technologies were developed and tested in the lab during the first 18 months of the project and then demonstrated on two actual systems, the USVI Water and Power Administration system and the New York Power Authority’s Blenheim-Gilboa pumped hydro plant in the last 18 months of the project. The four main thrusts of this project, mentioned above, are extremely important to the industry. The DSE with the achieved update rates (more than 60 times per second) provides a superior solution to the “grid visibility” question. The generator parameter identification method fills an important and practical need of the industry. The “energy function” based

  1. Site-specific landslide assessment in Alpine area using a reliable integrated monitoring system

    Science.gov (United States)

    Romeo, Saverio; Di Matteo, Lucio; Kieffer, Daniel Scott

    2016-04-01

    Rockfalls are one of major cause of landslide fatalities around the world. The present work discusses the reliability of integrated monitoring of displacements in a rockfall within the Alpine region (Salzburg Land - Austria), taking into account also the effect of the ongoing climate change. Due to the unpredictability of the frequency and magnitude, that threatens human lives and infrastructure, frequently it is necessary to implement an efficient monitoring system. For this reason, during the last decades, integrated monitoring systems of unstable slopes were widely developed and used (e.g., extensometers, cameras, remote sensing, etc.). In this framework, Remote Sensing techniques, such as GBInSAR technique (Groung-Based Interferometric Synthetic Aperture Radar), have emerged as efficient and powerful tools for deformation monitoring. GBInSAR measurements can be useful to achieve an early warning system using surface deformation parameters as ground displacement or inverse velocity (for semi-empirical forecasting methods). In order to check the reliability of GBInSAR and to monitor the evolution of landslide, it is very important to integrate different techniques. Indeed, a multi-instrumental approach is essential to investigate movements both in surface and in depth and the use of different monitoring techniques allows to perform a cross analysis of the data and to minimize errors, to check the data quality and to improve the monitoring system. During 2013, an intense and complete monitoring campaign has been conducted on the Ingelsberg landslide. By analyzing both historical temperature series (HISTALP) recorded during the last century and those from local weather stations, temperature values (Autumn-Winter, Winter and Spring) are clearly increased in Bad Hofgastein area as well as in Alpine region. As consequence, in the last decades the rockfall events have been shifted from spring to summer due to warmer winters. It is interesting to point out that

  2. A WSN based Environment and Parameter Monitoring System for Human Health Comfort: A Cloud Enabled Approach

    Directory of Open Access Journals (Sweden)

    Manohara Pai

    2014-05-01

    Full Text Available The number and type of sensors measuring physical and physiological parameters have seen dramatic increase due to progress in the MEMS and Nano Technology. The Wireless Sensor Networks (WSNs in turn is bringing new applications in environment monitoring and healthcare in order to improve the quality of service especially in hospitals. The adequacy of WSNs to gather critical information has provided solution but with limited storage, computation and scalability. This limitation is addressed by integrating WSN with cloud services. But, once the data enters the cloud the owner has no control over it. Hence confidentiality and integrity of the data being stored in the cloud are compromised. In this proposed work, secure sensor-cloud architecture for the applications in healthcare is implemented by integrating two different clouds. The sink node of WSN outsources data into the cloud after performing operations to secure the data. Since the SaaS and IaaS environments of Cloud Computing are provided by two different cloud service providers (CSPs, both the CSPs will not have complete information of the architecture. This provides inherent security as data storage and data processing are done on different clouds.

  3. Basic biochemical, hematological and hormonal parameters for monitoring the health and nutritional status in athletes

    Directory of Open Access Journals (Sweden)

    Aritz Urdampilleta

    2014-09-01

    Full Text Available Sporting competitions are becoming more demanding in terms of intensity of effort, and this means controlling all aspects that affect athletic performance. Food, hydration and supplementation, before, during and after training or competition directly affect health, body composition, performance and recovery of the athlete. The assessment of nutritional status is required for proper advising of the athlete, through blood tests to control the process of adaptation to training. The aim of this paper is to provide practical tools for dietitiansnutritionists to control the health and nutritional status of athletes, as well as monitoring their adaptation to workloads and competition periods. Performing analytical tests to control of protein metabolism, lipid profile, ions, blood tests and iron metabolism, in addition to review some hormonal parameters, may be of interest in order to observe the potential existence of overtraining states. The correct understanding and interpretation of laboratory tests (under sports doctor’s supervision will be most important and useful for dietitiansnutritionists, performing dietary and nutritional advice to athletes, because it will determine the status of the athlete and propose different individual feeding strategies depending on the training phase and response.

  4. Design of a telemetry system based on wireless power transmission for physiological parameter monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Jia, Zhiwei, E-mail: jiayege@hotmail.com [College of Electrical and Information Engineering, Changsha University of Science and Technology, Changsha (China); Yan, Guozheng; Zhu, Bingquan [820 Institute, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai (China)

    2015-04-15

    An implanted telemetry system for experimental animals with or without anaesthesia can be used to continuously monitor physiological parameters. This system is significant not only in the study of organisms but also in the evaluation of drug efficacy, artificial organs, and auxiliary devices. The system is composed of a miniature electronic capsule, a wireless power transmission module, a data-recording device, and a processing module. An electrocardiograph, a temperature sensor, and a pressure sensor are integrated in the miniature electronic capsule, in which the signals are transmitted in vitro by wireless communication after filtering, amplification, and A/D sampling. To overcome the power shortage of batteries, a wireless power transmission module based on electromagnetic induction was designed. The transmitting coil of a rectangular-section solenoid and a 3D receiving coil are proposed according to stability and safety constraints. Experiments show that at least 150 mW of power could pick up on the load in a volume of Φ10.5 mm × 11 mm, with a transmission efficiency of 2.56%. Vivisection experiments verified the feasibility of the integrated radio-telemetry system.

  5. Total monitor units influence on plan quality parameters in volumetric modulated arc therapy for breast case.

    Science.gov (United States)

    Mancosu, P; Reggiori, G; Alongi, F; Cozzi, L; Fogliata, A; Lobefalo, F; Navarria, P; Stravato, A; Tomatis, S; Scorsetti, M

    2014-05-01

    To investigate the correlation between total monitor units (MU), dosimetric findings, and pre-treatment quality assurance for volumetric modulated arc therapy (VMAT) by RapidArc (RA). Ten patients with breast cancer were considered. Dose prescriptions were: 48 Gy and 40.5 Gy in 15 fractions to, respectively, PTV(Boost) and PTVWholeBreast. A reference plan was optimized and four more plans using the "MU Objective", a tool for total MU controlling, were prepared imposing ± 20 and ± 50% total MU for inducing different complexities. Plan objectives were: D95% > 95% for both PTVs, and D2% Plans were evaluated in terms of technical parameters, dosimetric plan objectives findings and pre-treatment quality assurance (QA). Concerning PTVs, there were no significant differences for target coverage (D95%); mean doses for ipsilateral lung and controlateral breast, and V18 Gy for heart decreased with MUs increasing, reaching a plateau with reference plan. Body volume receiving low dose (V5-10 Gy) was minimized for reference plans. All plans had GAI (3 mm, 3%) > 95%. The data suggest that the best plan is the reference one, where the "MU Objective" tool was not used during optimisation. Nevertheless, it is advisable to use the "MU Objective" tool for re-planning when low GAI is found to increase its value. In this case, attention should be paid to OARs dose limits, since their values may be increased. Copyright © 2013 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  6. Distributed Multi-Sensor Real-Time Building Environmental Parameters Monitoring System with Remote Data Access

    Directory of Open Access Journals (Sweden)

    Beinarts Ivars

    2014-12-01

    Full Text Available In this paper the advanced monitoring system of multiple environmental parameters is presented. The purpose of the system is a long-term estimation of energy efficiency and sustainability for the research test stands which are made of different building materials. Construction of test stands, and placement of main sensors are presented in the first chapter. The structure of data acquisition system includes a real-time interface with sensors and a data logger that allows to acquire and log data from all sensors with fixed rate. The data logging system provides a remote access to the processing of the acquired data and carries out periodical saving at a remote FTP server using an Internet connection. The system architecture and the usage of sensors are explained in the second chapter. In the third chapter implementation of the system, different interfaces of sensors and energy measuring devices are discussed and several examples of data logger program are presented. Each data logger is reading data from analog and digital channels. Measurements can be displayed directly on a screen using WEB access or using data from FTP server. Measurements and acquired data graphical results are presented in the fourth chapter in the selected diagrams. The benefits of the developed system are presented in the conclusion.

  7. [Intraoperative monitoring in artificial respiration of premature and newborn infants. I. Monitoring of respiratory parameters and alveolar ventilation].

    Science.gov (United States)

    Lenz, G; Heipertz, W; Leidig, E; Madee, S

    1986-06-01

    Monitoring of ventilation serves to ensure adequate alveolar ventilation and arterial oxygenation, and to avoid pulmonary damage due to mechanical ventilation. Basic clinical monitoring, i.e., inspection, auscultation (including precordial or oesophageal stethoscope) and monitoring of heart rate and blood pressure, is mandatory. Mechanical ventilation is monitored by ventilation pressures (peak pressure, plateau pressure and endexpiratory pressure), ventilation volumes (measured at the in/expiratory valve of the respirator and by hot-wire anemometry at the tube connector), ventilation rate, and inspiratory oxygen concentration (FiO2). Alveolar ventilation should be continuously and indirectly recorded by capnometry (pECO2) and by measurement of transcutaneous pCO2 (tcpCO2), whereas oxygenation is determined via measurement of transcutaneous pO2 (tcpO2). Invasive monitoring of gas exchange is essential in prolonged or intrathoracic interventions as well as in neonates with cardiopulmonary problems. paCO2 may be estimated by capillary or venous blood gas analysis; arterial blood gas analysis is required for exact determination of paCO2 as well as arteriocutaneous pCO2 (atcDCO2) and arterio-end-expiratory (aEDCO2) gradients.

  8. The estimated sensitivity and specificity of compartment pressure monitoring for acute compartment syndrome.

    Science.gov (United States)

    McQueen, Margaret M; Duckworth, Andrew D; Aitken, Stuart A; Court-Brown, Charles M

    2013-04-17

    The aim of our study was to document the estimated sensitivity and specificity of continuous intracompartmental pressure monitoring for the diagnosis of acute compartment syndrome. From our prospective trauma database, we identified all patients who had sustained a tibial diaphyseal fracture over a ten-year period. A retrospective analysis of 1184 patients was performed to record and analyze the documented use of continuous intracompartmental pressure monitoring and the use of fasciotomy. A diagnosis of acute compartment syndrome was made if there was escape of muscles at fasciotomy and/or color change in the muscles or muscle necrosis intraoperatively. A diagnosis of acute compartment syndrome was considered incorrect if it was possible to close the fasciotomy wounds primarily at forty-eight hours. The absence of acute compartment syndrome was confirmed by the absence of neurological abnormality or contracture at the time of the latest follow-up. Of 979 monitored patients identified, 850 fit the inclusion criteria with a mean age of thirty-eight years (range, twelve to ninety-four years), and 598 (70.4%) were male (p compartment syndrome: 141 had acute compartment syndrome (true positives), six did not have it (false positives), and five underwent fasciotomy despite having a normal differential pressure reading, with subsequent operative findings consistent with acute compartment syndrome (false negatives). Of the 698 patients (82.1%) who did not undergo fasciotomy, 689 had no evidence of any late sequelae of acute compartment syndrome (true negatives) at a mean follow-up time of fifty-nine weeks. The estimated sensitivity of intracompartmental pressure monitoring for suspected acute compartment syndrome was 94%, with an estimated specificity of 98%, an estimated positive predictive value of 93%, and an estimated negative predictive value of 99%. The estimated sensitivity and specificity of continuous intracompartmental pressure monitoring for the diagnosis of

  9. Proposed parameters of specific rain attenuation prediction for Free Space Optics link operating in tropical region

    Science.gov (United States)

    Suriza, A. Z.; Md Rafiqul, Islam; Wajdi, A. K.; Naji, A. W.

    2013-03-01

    As the demand for higher and unlimited bandwidth for communication channel is increased, Free Space Optics (FSO) is a good alternative solution. As it is protocol transparent, easy to install, cost effective and have capabilities like fiber optics, its demand rises very fast. Weather condition, however is the limiting factor for FSO link. In the temperate region the major blockage for FSO link feasibility is fog. In the tropical region high rainfall rate is expected to be the major drawback of FSO link availability. Rain attenuation is the most significant to influence FSO link availability in tropical region. As for now the available k and α values are developed using data from temperate regions. Therefore, the objective of this paper is to propose new parameters for specific rain attenuation prediction model that represents tropical weather condition. The proposed values are derived from data measured in Malaysia and using methods recommended by ITU-R.

  10. The influence of colloidal parameters on the specific power absorption of PAA-coated magnetite nanoparticles

    Directory of Open Access Journals (Sweden)

    Pardiñas-Blanco Iván

    2011-01-01

    Full Text Available Abstract The suitability of magnetic nanoparticles (MNPs to act as heat nano-sources by application of an alternating magnetic field has recently been studied due to their promising applications in biomedicine. The understanding of the magnetic relaxation mechanism in biocompatible nanoparticle systems is crucial in order to optimize the magnetic properties and maximize the specific absorption rate (SAR. With this aim, the SAR of magnetic dispersions containing superparamagnetic magnetite nanoparticles bio-coated with polyacrylic acid of an average particle size of ≈10 nm has been evaluated separately by changing colloidal parameters such as the MNP concentration and the viscosity of the solvent. A remarkable decrease of the SAR values with increasing particle concentration and solvent viscosity was found. These behaviours have been discussed on the basis of the magnetic relaxation mechanisms involved. PACS: 80; 87; 87.85jf

  11. The influence of colloidal parameters on the specific power absorption of PAA-coated magnetite nanoparticles.

    Science.gov (United States)

    Piñeiro-Redondo, Yolanda; Bañobre-López, Manuel; Pardiñas-Blanco, Iván; Goya, Gerardo; López-Quintela, M Arturo; Rivas, José

    2011-05-16

    The suitability of magnetic nanoparticles (MNPs) to act as heat nano-sources by application of an alternating magnetic field has recently been studied due to their promising applications in biomedicine. The understanding of the magnetic relaxation mechanism in biocompatible nanoparticle systems is crucial in order to optimize the magnetic properties and maximize the specific absorption rate (SAR). With this aim, the SAR of magnetic dispersions containing superparamagnetic magnetite nanoparticles bio-coated with polyacrylic acid of an average particle size of ≈10 nm has been evaluated separately by changing colloidal parameters such as the MNP concentration and the viscosity of the solvent. A remarkable decrease of the SAR values with increasing particle concentration and solvent viscosity was found. These behaviours have been discussed on the basis of the magnetic relaxation mechanisms involved.PACS: 80; 87; 87.85jf.

  12. [Construction and analysis of a monitoring system with remote real-time multiple physiological parameters based on cloud computing].

    Science.gov (United States)

    Zhu, Lingyun; Li, Lianjie; Meng, Chunyan

    2014-12-01

    There have been problems in the existing multiple physiological parameter real-time monitoring system, such as insufficient server capacity for physiological data storage and analysis so that data consistency can not be guaranteed, poor performance in real-time, and other issues caused by the growing scale of data. We therefore pro posed a new solution which was with multiple physiological parameters and could calculate clustered background data storage and processing based on cloud computing. Through our studies, a batch processing for longitudinal analysis of patients' historical data was introduced. The process included the resource virtualization of IaaS layer for cloud platform, the construction of real-time computing platform of PaaS layer, the reception and analysis of data stream of SaaS layer, and the bottleneck problem of multi-parameter data transmission, etc. The results were to achieve in real-time physiological information transmission, storage and analysis of a large amount of data. The simulation test results showed that the remote multiple physiological parameter monitoring system based on cloud platform had obvious advantages in processing time and load balancing over the traditional server model. This architecture solved the problems including long turnaround time, poor performance of real-time analysis, lack of extensibility and other issues, which exist in the traditional remote medical services. Technical support was provided in order to facilitate a "wearable wireless sensor plus mobile wireless transmission plus cloud computing service" mode moving towards home health monitoring for multiple physiological parameter wireless monitoring.

  13. Chromosome Specific Substitution Lines of Aegilops geniculata Alter Parameters of Bread Making Quality of Wheat

    Science.gov (United States)

    Tsujimoto, Hisashi; Gupta, Raj Kumar; Kumar, Aman; Kaur, Navneet; Kumar, Rohit; Chunduri, Venkatesh; Sharma, Nand Kishor; Chawla, Meenakshi; Sharma, Saloni; Mundey, Jaspreet Kaur

    2016-01-01

    Wheat cultivars with wide introgression have strongly impacted global wheat production. Aegilops geniculata (MgUg) is an important wild relative with several useful traits that can be exploited for wheat improvement. Screening of Ae. geniculata addition lines indicated a negative effect of 1Ug and the positive effect of 1Mg chromosome on wheat dough strength. Negative effect of 1Ug is probably associated with variation in number and position of the tripeptide repeat motif in the high molecular weight glutenin (HMW-G) gene. To utilize the positive potential of 1Mg chromosome, three disomic substitution lines (DSLs) 1Mg(1A), 1Mg(1B) and 1Mg(1D) were created. These lines were characterized for morphological, cytogenetic properties and biochemical signatures using FISH, 1D-, 2D-PAGE and RP-HPLC. Contribution of wheat 1A, 1B and 1D chromosomes towards dough mixing and baking parameters, chapatti quality, Fe/Zn content and glume color were identified. Observed order of variation in the dough mixing and baking parameters {1Mg(1D) ≤wheat ≤1Mg(1B) ≤1Mg(1A)} indicated that chromosome specific introgression is desirable for best utilization of wild species’ potential. PMID:27755540

  14. Are patient-specific joint and inertial parameters necessary for accurate inverse dynamics analyses of gait?

    Science.gov (United States)

    Reinbolt, Jeffrey A; Haftka, Raphael T; Chmielewski, Terese L; Fregly, Benjamin J

    2007-05-01

    Variations in joint parameter (JP) values (axis positions and orientations in body segments) and inertial parameter (IP) values (segment masses, mass centers, and moments of inertia) as well as kinematic noise alter the results of inverse dynamics analyses of gait. Three-dimensional linkage models with joint constraints have been proposed as one way to minimize the effects of noisy kinematic data. Such models can also be used to perform gait optimizations to predict post-treatment function given pre-treatment gait data. This study evaluates whether accurate patient-specific JP and IP values are needed in three-dimensional linkage models to produce accurate inverse dynamics results for gait. The study was performed in two stages. First, we used optimization analyses to evaluate whether patient-specific JP and IP values can be calibrated accurately from noisy kinematic data, and second, we used Monte Carlo analyses to evaluate how errors in JP and IP values affect inverse dynamics calculations. Both stages were performed using a dynamic, 27 degrees-of-freedom, full-body linkage model and synthetic (i.e., computer generated) gait data corresponding to a nominal experimental gait motion. In general, JP but not IP values could be found accurately from noisy kinematic data. Root-mean-square (RMS) errors were 3 degrees and 4 mm for JP values and 1 kg, 22 mm, and 74 500 kg * mm2 for IP values. Furthermore, errors in JP but not IP values had a significant effect on calculated lower-extremity inverse dynamics joint torques. The worst RMS torque error averaged 4% bodyweight * height (BW * H) due to JP variations but less than 0.25% (BW * H) due to IP variations. These results suggest that inverse dynamics analyses of gait utilizing linkage models with joint constraints should calibrate the model's JP values to obtain accurate joint torques.

  15. Using Analytical and Numerical Modeling to Assess the Utility of Groundwater Monitoring Parameters at Carbon Capture, Utilization, and Storage Sites

    Science.gov (United States)

    Porse, S. L.; Hovorka, S. D.; Young, M.; Zeidouni, M.

    2012-12-01

    Carbon capture, utilization, and storage (CCUS) is becoming an important bridge to commercial geologic sequestration (GS) to help reduce anthropogenic CO2 emissions. While CCUS at brownfield sites (i.e. mature oil and gas fields) has operational advantages over GS at greenfield sites (i.e. saline formations) such as the use of existing well infrastructure, previous site activities can add a layer of complexity that must be accounted for when developing groundwater monitoring protection networks. Extensive work has been done on developing monitoring networks at GS sites for CO2 accounting and groundwater protection. However, the development of appropriate monitoring strategies at commercial brownfield sites continues to develop. The goals of this research are to address the added monitoring complexity by adapting simple analytical and numerical models to test these approaches using two common subsurface monitoring parameters, pressure and aqueous geochemistry. The analytical pressure model solves for diffusivity in radial coordinates and the leakage rate derived from Darcy's law. The aqueous geochemical calculation computer program PHREEQC solves the advection-reaction-dispersion equation for 1-D transport and mixing of fluids .The research was conducted at a CO2 enhanced oil recovery (EOR) field on the Gulf Coast of Texas. We modeled the performance over time of one monitoring well from the EOR field using physical and operational data including lithology and water chemistry samples, and formation pressure data. We explored through statistical analyses the probability of leakage detection using the analytical and numerical methods by varying the monitoring well location spatially and vertically with respect to a leaky fault. Preliminary results indicate that a pressure based subsurface monitoring system provides a better probability of leakage detection than geochemistry alone, but together these monitoring parameters can improve the chances of leakage detection

  16. Monitoring Different Phonological Parameters of Sign Language Engages the Same Cortical Language Network but Distinctive Perceptual Ones

    OpenAIRE

    Cardin, Velia; Orfanidou, Eleni; Kästner, Lena; Rönnberg, Jerker; Woll, Bencie; Cheryl M Capek; Rudner, Mary

    2016-01-01

    The study of signed languages allows the dissociation of sensorimotor and cognitive neural components of the language signal. Here we investigated the neurocognitive processes underlying the monitoring of two phonological parameters of sign languages: handshape and location. Our goal was to determine if brain regions processing sensorimotor characteristics of different phonological parameters of sign languages were also involved in phonological processing, with their activity being modulated ...

  17. Subject-specific body segment parameters' estimation using biplanar X-rays: a feasibility study.

    Science.gov (United States)

    Sandoz, Baptiste; Laporte, Sébastien; Skalli, Wafa; Mitton, David

    2010-12-01

    In order to improve the reliability of children's models, the aim of this study was to determine the subject-specific masses and 3D locations of the centres of mass (CoM) of body segments using biplanar X-rays. Previous methods, validated on upper leg segments, were applied to the whole body. Six children and six adults were studied. The low-dose X-ray system EOS(®) was used to simultaneously get head-to-foot biplanar X-rays in the upright position. Specific methods were used to get 3D reconstructions of bones and body shape. The densities from the literature were used to define the masses. To assess the accuracy of the reconstructions, a force plate was used to compare the mass and the projection of the CoM. A mean distance of 4.5 mm between the measured and the calculated projections of the CoM was found. The mean error between the estimated and the actual body mass was 2.6%. Such a method will be useful in obtaining the body segment parameters in children, hard to obtain using direct measurement techniques.

  18. Mean reticulocyte volume: a specific parameter to screen for hereditary spherocytosis.

    Science.gov (United States)

    Xu, Yuchan; Yang, Wang; Liao, Lin; Deng, Zengfu; Qiu, Yuling; Chen, Wenqiang; Lin, Faquan

    2016-02-01

    This study assessed the value of mean reticulocyte volume (MRV) for differential diagnosis of hereditary spherocytosis (HS) so as to develop conventional and new specific screen indexes. Subjects in this study were divided into three groups: 53 cases in HS group, 217 cases in hemolytic anemia control group (109 cases of thalassemia (THAL), 56 cases of glucose-6-phosphate dehydrogenase G6PD deficiency anemia, and 52 cases of autoimmune hemolytic anemia (AIHA)), and 100 cases in healthy control group. We analyzed erythrocyte and reticulocyte parameters including MRV, mean sphered corpuscular volume, mean corpuscular hemoglobin concentration, and immature reticulocyte fraction. Results demonstrated that MRV was significantly lower in the HS group but significantly higher in the AIHA and G6PD deficiency anemia groups than that in the healthy control group (P = 0.000). MRV was not significantly different between the AIHA and G6PD deficiency anemia groups (P = 0.977) and between the healthy control and THAL groups (P = 0.168). The area under the ROC curve of MRV for diagnosis of HS was 0.942, with a standard error of 0.019, 95% confidence interval of 0.905-0.979, and optimal critical diagnosis point of 95.77 fL. When the MRV was ≤95.77 fL, the sensitivity and specificity for diagnosis of HS were 86.80% and 91.20%, respectively. Therefore, MRV is a general and specific new index for screening HS and important for differential diagnosis of different types of hemolytic anemia.

  19. A new permanent multi-parameter monitoring network in Central Asian high mountains – from measurements to data bases

    Directory of Open Access Journals (Sweden)

    T. Schöne

    2013-02-01

    Full Text Available Long-term monitoring of water resources and climate parameters at the scale of river basins requires networks of continuously operated in-situ stations. Since 2009, GFZ and CAIAG, in cooperation with the National Hydrometeorological Services (NHMS of Central Asia, are establishing such a regional monitoring network in Kazakhstan, Kyrgyzstan, Tajikistan, Uzbekistan, and lately Afghanistan to collect observations of meteorological and hydrological parameters and to deliver them to the end-users for operational tasks and scientific studies. The newly developed and installed remotely operated multi-parameter stations (ROMPS do not only monitor standard meteorological and hydrological parameters, but also deliver Global Navigation Satellite System (GNSS data for atmospheric sounding as well as tectonic studies. Additionally, three stations integrate seismic sensors for earthquake monitoring. The observational data from the ROMPS is transmitted nominally in near-real time, but at least once a day to a centralized geo-database infrastructure for long-term storage and data redistribution. Users can access the data manually using a web-interface or automatically using SOS requests; in addition, data is planed to be distributed to the NHMS through standard communication and data exchange channels.

  20. A new permanent multi-parameter monitoring network in Central Asian high mountains – from measurements to data bases

    Directory of Open Access Journals (Sweden)

    T. Schöne

    2012-06-01

    Full Text Available Long-term monitoring of water resources and climate parameters at the scale of river basins requires networks of continuously operated in-situ stations. Since 2009, GFZ and CAIAG, in cooperation with the National Hydrometeorological Services (NHMS, are establishing such a regional monitoring network in Central Asia (Kazakhstan, Kyrgyzstan, Tajikistan, Uzbekistan, and Afghanistan which is collecting observations of meteorological and hydrological parameters and delivering them to the end-users. The network design focuses mainly on the higher elevations where the recent decline of monitoring stations and networks established in Soviet times was strongest, and the resulting observational gap hinders research on climate and hydrological change as well as operational tasks in water management such as the seasonal runoff forecast. The newly developed and installed Remotely Operated Multi-Parameter Stations (ROMPS do not only monitor standard meteorological and hydrological parameters, but also deliver GPS data for atmospheric sounding as well as tectonic studies. The observational data from the ROMPS is transmitted at least once a day to a centralized geo-database infrastructure for long-term storage and data redistribution. Users can access the data manually using a web-interface or automatically using SOS requests; in addition, data is distributed to the NHMS through standard communication and data exchange channels.

  1. Slice-selective gradient-encoded CEST spectroscopy for monitoring dynamic parameters and high-throughput sample characterization

    Science.gov (United States)

    Döpfert, Jörg; Witte, Christopher; Schröder, Leif

    2013-12-01

    Chemical Exchange Saturation Transfer (CEST) NMR is an increasingly used technique for generating molecule or microenvironment specific signal contrast. To characterize CEST agents and to extract parameters such as temperature and pH, it is often required to resolve the spectral dimension. This is achieved by recording so called CEST- or z-spectra, where the spectral CEST information is conventionally acquired point by point, leading to long acquisition times. Here, we employ gradient-encoding to substantially accelerate the acquisition process of z-spectra in phantom experiments, reducing it to only two scans. This speedup allows us to monitor dynamic processes such as rapid temperature changes in a PARACEST sample that would be inaccessible with the conventional encoding. Furthermore, we combine the gradient-encoding approach with multi-slice selection, thus reserving one spatial dimension for the simultaneous investigation of heterogeneous PARACEST sample packages within one experiment. Hence, gradient-encoded CEST might be of great use for high-throughput screening of CEST contrast agents.

  2. (abstract) Using an Inversion Algorithm to Retrieve Parameters and Monitor Changes over Forested Areas from SAR Data

    Science.gov (United States)

    Moghaddam, Mahta

    1995-01-01

    In this work, the application of an inversion algorithm based on a nonlinear opimization technique to retrieve forest parameters from multifrequency polarimetric SAR data is discussed. The approach discussed here allows for retrieving and monitoring changes in forest parameters in a quantative and systematic fashion using SAR data. The parameters to be inverted directly from the data are the electromagnetic scattering properties of the forest components such as their dielectric constants and size characteristics. Once these are known, attributes such as canopy moisture content can be obtained, which are useful in the ecosystem models.

  3. Approach for long term environmental parameters monitoring process using data acquisition devices and high level applications for data processing

    Science.gov (United States)

    Croitoru, Bogdan; Boca, Loredana; Abrudean, Mihail; Joldes, Remus

    2010-11-01

    Present paper describes a long term monitoring process of few environmental parameters for evaluating green energy potential (wind energy and solar energy) of a small geographical area (~ 32 km2). The monitoring approach presented in this paper consists in: real-time data acquisition process using two real-time data acquisition devices (DAQ); a wireless network used for long distance data transmission in order to send all acquired data to a remote location for processing; Virtual Instrument (VI's) applications used for controlling data acquisition devices and the acquisition process; a network protocol analyzer used for a detailed analysis of the communication protocols and data packets; the management of the huge volume of sensor data by using a high level software application; long term sensor monitoring using a complex graphic software application. The measured environment parameters are the following: wind speed, wind direction, temperature, sun intensity and illumination, steel pylon vibrations on three axes.

  4. Element-specific and constant parameters used for dose calculations in SR-Site

    Energy Technology Data Exchange (ETDEWEB)

    Norden, Sara (Svensk Kaernbraenslehantering AB (Sweden)); Avila, Rodolfo; De la Cruz, Idalmis; Stenberg, Kristofer; Grolander, Sara (Facilia AB (Sweden))

    2010-12-15

    The report presents Best Estimate (BE) values and Probability Distribution Functions (PDFs) of Concentration Ratios (CR) for different types of terrestrial and aquatic biota and distribution coefficients (K{sub d}) for organic and inorganic deposits, as well as for suspended matter in freshwater and marine ecosystems. The BE values have been used in deterministic simulations for derivation of Landscape Dose Factors (LDF) applied for dose assessments in SR-Site. The PDFs have been used in probabilistic simulations for uncertainty and sensitivity analysis of the LDFs. The derivation of LDFs for SR-Site is described in /Avila et al. 2010/. The CR and K{sub d} values have been derived using both site-specific data measured at Laxemar and Forsmark during the site investigation program and literature data. These two data sources have been combined using Bayesian updating methods, which are described in detail in an Appendix, along with the input data used in the statistical analyses and the results obtained. The report also describes a kinetic-allometric model that was applied for deriving values of CR for terrestrial herbivores in cases when site and literature data for an element were missing. In addition, the report presents values for a number of other parameters used in the SR-Site Radionuclide Model for the biosphere: radionuclide decay-ingrowth data, elemental diffusivities, fractions of element content released during decomposition processes, ingestion of food, water and soil by cattle, elements retention fraction on plant surfaces during irrigation. The report also presents parameter values used in calculation of doses to a reference man: dose coefficients for inhalation, ingestion and external exposure, inhalation rates, ingestion rates of food and water

  5. A novel method for monitoring functional lesion-specific recruitment of repair proteins in live cells

    Energy Technology Data Exchange (ETDEWEB)

    Woodrick, Jordan; Gupta, Suhani; Khatkar, Pooja; Dave, Kalpana; Levashova, Darya; Choudhury, Sujata; Elias, Hadi; Saha, Tapas; Mueller, Susette; Roy, Rabindra, E-mail: rr228@georgetown.edu

    2015-05-15

    Highlights: • A method of monitoring lesion-specific recruitment of proteins in vivo is described. • Recruitment of repair enzymes to abasic sites is monitored by co-localization. • Repair protein recruitment is consistent with known protein–protein relationships. • Cells demonstrated complete repair of abasic sites by 90 min. - Abstract: DNA–protein relationships have been studied by numerous methods, but a particular gap in methodology lies in the study of DNA adduct-specific interactions with proteins in vivo, which particularly affects the field of DNA repair. Using the repair of a well-characterized and ubiquitous adduct, the abasic (AP) site, as a model, we have developed a comprehensive method of monitoring DNA lesion-specific recruitment of proteins in vivo over time. We utilized a surrogate system in which a Cy3-labeled plasmid containing a single AP-site was transfected into cells, and the interaction of the labeled DNA with BER enzymes, including APE1, Polβ, LIG1, and FEN1, was monitored by immunofluorescent staining of the enzymes by Alexafluor-488-conjugated secondary antibody. The recruitment of enzymes was characterized by quantification of Cy3-Alexafluor-488 co-localization. To validate the microscopy-based method, repair of the transfected AP-site DNA was also quantified at various time points post-transfection using a real time PCR-based method. Notably, the recruitment time kinetics for each enzyme were consistent with AP-site repair time kinetics. This microscopy-based methodology is reliable in detecting the recruitment of proteins to specific DNA substrates and can be extended to study other in vivo DNA–protein relationships in any DNA sequence and in the context of any DNA structure in transfectable proliferating or quiescent cells. The method may be applied to a variety of disciplines of nucleic acid transaction pathways, including repair, replication, transcription, and recombination.

  6. Selection and Traceability of Parameters To Support Hanford-Specific RESRAD Analyses -- Fiscal Year 2008 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Last, George V.; Rockhold, Mark L.; Murray, Christopher J.; Cantrell, Kirk J.

    2009-07-24

    In fiscal years 2007 and 2008, the Hanford Site Groundwater Remediation Project, formerly managed by Fluor Hanford, Inc., requested the Pacific Northwest National Laboratory (PNNL) to support the development and initial implementation of a strategy to establish and maintain, under configuration control, a set of Hanford-specific flow and transport parameter estimates that can be used to support Hanford Site assessments. This document provides a summary of those efforts, culminating in a set of best-estimate Hanford-specific parameters for use in place of the default parameters used in the RESRAD code. The RESRAD code is a computer model designed to estimate radiation doses and risks from RESidual RADioactive materials. The long-term goals of the PNNL work are to improve the consistency, defensibility, and traceability of parameters and their ranges of variability, and to ensure a sound basis for assigning parameters for flow and transport models in the code. The strategy was to start by identifying the existing parameter data sets most recently used in site assessments, documenting these parameter data sets and the raw data sets on which they were based, and using the existing parameter sets to define best-estimate parameters for use in the RESRAD code. The Hanford-specific assessment parameters compiled for use in RESRAD are traceable back to the professional judgment of the authors of published documents. Within the references, parameters are often not directly traceable back to the raw data and analytical approaches used to derive the assessment parameters. Future activities will work to continuously improve the defensibility and traceability of the parameter data sets and to address limitations and technical issues associated with the existing assessment parameter data sets.

  7. Establishment of reference interval for liver specific biochemical parameters in apparently healthy north Indian population.

    Science.gov (United States)

    Yadav, Dharamveer; Mishra, Sandhya; Gupta, Monika; John, P J; Sharma, Praveen

    2013-01-01

    Reference intervals (RI) are the most common decision support tool used for interpretation of numerical laboratory reports. The quality of the RI can play as large a role in result interpretation as the quality of the result itself. As such there is hardly any study examining RI for liver specific biochemical parameters in Indian population especially north Indians having drastically different food habits as compared to rest of the India. So there is a need to establish the RI for north Indian population. Present study was conducted on 2,021 apparently healthy individuals of north Indian origin ranging in age from 15-60 years, were selected randomly using defined criteria. Lipemic, hemolysed, icteric and stored samples were also excluded adopting preanalytical criteria for rejection of sample. Non parametric methodology for determination of RI was adopted as most of the biochemical parameters included revealed non Gaussian distribution. Data were analyzed for middle 95 percentile (2.5th-97.5th percentile), median and 95 % confidence interval using SPSS software package version 10.0. The upper and the lower limit of RI (reported Vs observed) for bilirubin (0-1.2 Vs 0.30-1.30 mg/dL), serum glutamate oxaloacetate transferase (SGOT) (0-41 Vs 13-52.80 IU/L), serum glutamate pyruvate transferase (SGPT) (0-50 Vs 10-68 IU/L) showed wide variation as compared to reported standard RI however Gamma glutamyl transferase (GGT) (0-50 Vs 5.00-50.60 IU/L) remained within the reported standard RI. Further gender wise evaluation revealed higher cutoff in males (AST 14-55, ALT 11-70.35, GGT 6.76-51.09 in IU/L, bilirubin (0.40-1.34 mg/dL) as compared to females (SGOT 13-50.43, SGPT 9-63.43, GGT 3.92-48.70 in IU/L, Bilirubin 0.30-1.20 mg/dL) for both enzymatic and non enzymatic biochemical parameters. The variations may be attributed to dietary pattern smoking and alcoholism.

  8. Monitoring internal load parameters during competitive synchronized swimming duet routines in elite athletes.

    Science.gov (United States)

    Rodríguez-Zamora, Lara; Iglesias, Xavier; Barrero, Anna; Torres, Lorena; Chaverri, Diego; Rodríguez, Ferran A

    2014-03-01

    The aim of the study is to compare the heart rate (HR) and rate of perceived exertion (RPE) responses as internal load indicators while performing duet routines during training and competition, both in the technical and free programs of synchronized swimming (SS). Participants were 10 SS Olympic medalists (age, 17.4 ± 3.0 years; height, 164.0 ± 6.1 cm; body mass, 52.0 ± 6.4 kg; training, 36.3 ± 6.2 h·wk; experience, 9.2 ± 2.6 years). They were monitored while performing the same technical duet or free duet, during a training session (T) and during an official competition (C). Heart rate was continuously monitored. Rate of perceived exertion was assessed using the Borg CR10 scale. Heart rate responses during T and C were almost identical: pre-exercise mean HR (b·min) was 130.5 ± 13.9 (T) and 133.6 ± 7.7 (C) and quickly increased yielding mean peak values of 184.8 ± 5.8 (T) and 184.8 ± 6.6 (C), with interspersed bradycardic events down to 86.6 ± 4 (T) and 86.3 ± 5 (C). Routines were perceived as "hard" to "extremely hard" by the swimmers in both conditions, and mean RPE scores (0-10+) were equally high during C (7.9 ± 1.2) and T (7.5 ± 1.2) (p = 0.223). Rate of perceived exertion inversely correlated with minimum (R = -0.545; p = 0.008) and mean HR (R = -0.452; p = 0.026) and positively correlated with HRrange (R = 0.520; p = 0.011). The internal load imposed by SS duets performed during training is virtually identical to that elicited in a real competitive situation. Therefore, practicing competitive routines is suitable for developing and maintaining the cardiovascular fitness that is needed for specific conditioning in elite synchronized swimmers, with the added value of favoring exercise automaticity, interindividual coordination, and artistic expression simultaneously.

  9. Using data on social contacts to estimate age-specific transmission parameters for respiratory-spread infectious agents.

    NARCIS (Netherlands)

    Wallinga, Jacco; Teunis, Peter F M; Kretzschmar, Mirjam

    2006-01-01

    The estimation of transmission parameters has been problematic for diseases that rely predominantly on transmission of pathogens from person to person through small infectious droplets. Age-specific transmission parameters determine how such respiratory agents will spread among different age groups

  10. Methane dissociation on Pt(111): Searching for a specific reaction parameter density functional

    Energy Technology Data Exchange (ETDEWEB)

    Nattino, Francesco, E-mail: f.nattino@chem.leidenuniv.nl; Migliorini, Davide; Kroes, Geert-Jan [Leiden Institute of Chemistry, Leiden University, Gorlaeus Laboratories, P.O. Box 9502, 2300 RA Leiden (Netherlands); Bonfanti, Matteo [Dipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, 20133 Milano (Italy)

    2016-01-28

    The theoretical description of methane dissociating on metal surfaces is a current frontier in the field of gas-surface dynamics. Dynamical models that aim at achieving a highly accurate description of this reaction rely on potential energy surfaces based on density functional theory calculations at the generalized gradient approximation. We focus here on the effect that the exchange-correlation functional has on the reactivity of methane on a metal surface, using CHD{sub 3} + Pt(111) as a test case. We present new ab initio molecular dynamics calculations performed with various density functionals, looking also at functionals that account for the van der Waals (vdW) interaction. While searching for a semi-empirical specific reaction parameter density functional for this system, we find that the use of a weighted average of the PBE and the RPBE exchange functionals together with a vdW-corrected correlation functional leads to an improved agreement with quantum state-resolved experimental data for the sticking probability, compared to previous PBE calculations. With this semi-empirical density functional, we have also investigated the surface temperature dependence of the methane dissociation reaction and the influence of the rotational alignment on the reactivity, and compared our results with experiments.

  11. Changes in Hematological, Biochemical and Non-specific Immune Parameters of Olive Flounder, , Following Starvation

    Directory of Open Access Journals (Sweden)

    Jong-Hyun Kim

    2014-09-01

    Full Text Available Triplicate groups of fed and starved olive flounder, Paralichthys olivaceus (body weight: 119.8±17.46 g, were examined over 42 days for physiological changes using hematological, biochemical, and non-specific immune parameters. No significant differences in concentrations of blood hemoglobin and hematocrit and plasma levels of total cholesterol, aspartate aminotransferase, alanine aminotransferase, glucose, and cortisol were detected between fed and starved groups at any sampling time throughout the experiment. In contrast, plasma total protein concentrations were significantly lower in starved fish than in fed fish from day 7 onwards. Moreover, plasma lysozyme concentrations were significantly higher in starved flounder from day 21 onwards. This result confirms that the response of olive flounder to short-term (less than about 1.5 months starvation consists of a readjustment of metabolism rather than the activation of an alarm-stress response. The present results indicate that starvation does not significantly compromise the health status of fish despite food limitation.

  12. Recommended environmental dose calculation methods and Hanford-specific parameters. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Schreckhise, R.G.; Rhoads, K.; Napier, B.A.; Ramsdell, J.V. [Pacific Northwest Lab., Richland, WA (United States); Davis, J.S. [Westinghouse Hanford Co., Richland, WA (United States)

    1993-03-01

    This document was developed to support the Hanford Environmental Dose overview Panel (HEDOP). The Panel is responsible for reviewing all assessments of potential doses received by humans and other biota resulting from the actual or possible environmental releases of radioactive and other hazardous materials from facilities and/or operations belonging to the US Department of Energy on the Hanford Site in south-central Washington. This document serves as a guide to be used for developing estimates of potential radiation doses, or other measures of risk or health impacts, to people and other biota in the environs on and around the Hanford Site. It provides information to develop technically sound estimates of exposure (i.e., potential or actual) to humans or other biotic receptors that could result from the environmental transport of potentially harmful materials that have been, or could be, released from Hanford operations or facilities. Parameter values and information that are specific to the Hanford environs as well as other supporting material are included in this document.

  13. Generation and characterization of quinolone-specific DNA aptamers suitable for water monitoring.

    Science.gov (United States)

    Reinemann, C; Freiin von Fritsch, U; Rudolph, S; Strehlitz, B

    2016-03-15

    Quinolones are antibiotics that are accredited in human and veterinary medicine but are regularly used in high quantities also in industrial livestock farming. Since these compounds are often only incompletely metabolized, significant amounts contaminate the aquatic environment and negatively impact on a variety of different ecosystems. Although there is increasing awareness of problems caused by pharmaceutical pollution, available methods for the detection and elimination of numerous pharmaceutical residues are currently inefficient or expensive. While this also applies to antibiotics that may lead to multi-drug resistance in pathogenic bacteria, aptamer-based technologies potentially offer alternative approaches for sensitive and efficient monitoring of pharmaceutical micropollutants. Using the Capture-SELEX procedure, we here describe the selection of an aptamer pool with enhanced binding qualities for fluoroquinolones, a widely used group of antibiotics in both human and veterinary medicine. The selected aptamers were shown to detect various quinolones with high specificity, while specific binding activities to structurally unrelated drugs were not detectable. The quinolone-specific aptamers bound to ofloxacin, one of the most frequently prescribed fluoroquinolone, with high affinity (KD=0.1-56.9 nM). The functionality of quinolone-specific aptamers in real water samples was demonstrated in local tap water and in effluents of sewage plants. Together, our data suggest that these aptamers may be applicable as molecular receptors in biosensors or as catcher molecules in filter systems for improved monitoring and treatment of polluted water.

  14. Simultaneous estimation of local-scale and flow path-scale dual-domain mass transfer parameters using geoelectrical monitoring

    Science.gov (United States)

    Briggs, Martin A.; Day-Lewis, Frederick D.; Ong, John B.; Curtis, Gary P.; Lane, Jr., John W.

    2013-01-01

    Anomalous solute transport, modeled as rate-limited mass transfer, has an observable geoelectrical signature that can be exploited to infer the controlling parameters. Previous experiments indicate the combination of time-lapse geoelectrical and fluid conductivity measurements collected during ionic tracer experiments provides valuable insight into the exchange of solute between mobile and immobile porosity. Here, we use geoelectrical measurements to monitor tracer experiments at a former uranium mill tailings site in Naturita, Colorado. We use nonlinear regression to calibrate dual-domain mass transfer solute-transport models to field data. This method differs from previous approaches by calibrating the model simultaneously to observed fluid conductivity and geoelectrical tracer signals using two parameter scales: effective parameters for the flow path upgradient of the monitoring point and the parameters local to the monitoring point. We use regression statistics to rigorously evaluate the information content and sensitivity of fluid conductivity and geophysical data, demonstrating multiple scales of mass transfer parameters can simultaneously be estimated. Our results show, for the first time, field-scale spatial variability of mass transfer parameters (i.e., exchange-rate coefficient, porosity) between local and upgradient effective parameters; hence our approach provides insight into spatial variability and scaling behavior. Additional synthetic modeling is used to evaluate the scope of applicability of our approach, indicating greater range than earlier work using temporal moments and a Lagrangian-based Damköhler number. The introduced Eulerian-based Damköhler is useful for estimating tracer injection duration needed to evaluate mass transfer exchange rates that range over several orders of magnitude.

  15. The development of a computerized crop-specific drought monitoring system

    Energy Technology Data Exchange (ETDEWEB)

    Lourens, U.W.; Jager, J.M. de [Univ. of the Orange Free State, Bloemfontein (South Africa). Dept. of Agrometeorology

    1995-12-31

    A near real-time crop-specific drought monitoring system (DMS) that combines crop modeling and a Geographical Information System (GIS) has been developed in South Africa. The system is intended for use in decision support by resource managers concerned with drought aid. The condition of maize, wheat and rangeland can presently be monitored in the DMS. The system is a spatially distributed system with individual simulations being run for areas covering approximately 14 km{sup 2}. Values of the weather elements used to drive the models are obtained through interpolation of ground observations and processing of weather satellite imagery. Monitoring is undertaken throughout a production season, with updates provided on a fortnightly basis. Predictions of expected yield at the end of the season are made by using observed data up to the current date and completing the season with surrogate historical weather data. Appropriate surrogate scenarios are chosen based on the current season. After each monitoring run, simulated yield predictions for the season are compared with expected long-term yields of the crop produced in a particular region. A drought index class is assigned based on this comparison. Maps and tabulated information are produced in the GIS showing the spatial distribution of drought stricken areas and the intensity of drought in these areas. The maps and tables are distributed to government institutions and agricultural cooperatives.

  16. The effects of feed-borne Fusarium mycotoxins and glucomannan in turkey poults based on specific and non-specific parameters.

    Science.gov (United States)

    Devreese, Mathias; Girgis, George N; Tran, Si-Trung; De Baere, Siegrid; De Backer, Patrick; Croubels, Siska; Smith, Trevor K

    2014-01-01

    An experiment was conducted to investigate the effects of feeding grains naturally contaminated with Fusarium mycotoxins and a yeast derived glucomannan mycotoxin adsorbent (GMA) on selected specific and non-specific parameters in turkey poults. Two hundred and forty 1-day-old male turkey poults were fed the experimental diets for twelve weeks. Experimental diets were formulated with control grains, control grains+0.2% GMA, naturally-contaminated grains, or naturally-contaminated grains+0.2% GMA. Deoxynivalenol (DON) was the major contaminant of the contaminated grains and concentrations varied from 4.0 to 6.5 mg/kg in the contaminated diets. Non-specific parameters measured included: performance parameters, plasma biochemistry profiles, morphometry and CD8(+) T-lymphocyte counts in the duodenum. Plasma concentrations of DON and de-epoxydeoxynivalenol (DOM-1) were used as specific parameters. Performance parameters and plasma biochemistry were altered by the feeding of contaminated diets and GMA but this was not consistent throughout the trial. The feeding of contaminated diets reduced duodenal villus height and apparent villus surface area. This effect was prevented by GMA supplementation. The feeding of contaminated diets elevated total duodenal CD8(+) T-lymphocyte counts but this effect was not prevented by GMA. No significant differences were seen in plasma concentrations of DON and DOM-1 comparing birds fed contaminated and contaminated+GMA diets suggesting that GMA did not prevent DON absorption under these conditions.

  17. HOPF BIFURCATION AND CHAOS OF FINANCIAL SYSTEM ON CONDITION OF SPECIFIC COMBINATION OF PARAMETERS

    Institute of Scientific and Technical Information of China (English)

    Junhai MA; Yaqiang CUI; Lixia LIU

    2008-01-01

    This paper studies the global bifurcation and Hopf bifurcation of one kind of complicated financial system with different parameter combinations. Conditions on which bifurcation happens, and the critical system structure when the system transforms from one kind of topological structure to another are studied as well. The criterion for identifying Hopf bifurcation under different parameter combinations is also given. The chaotic character of this system under quasi-periodic force is finally studied. The bifurcation structure graphs are given when two parameters of the combination are fixed while the other parameter varies. The presence and stability of 2 and 3 dimensional torus bifurcation are studied. All of the Lyapunov exponents of the system with different bifurcation parameters and routes leading the system to chaos with different parameter combinations are studied. It is of important theoretical and practical meaning to probe the intrinsic mechanism of such continuous complicated financial system and to find the macro control policies for such kind of system.

  18. Wi-Fi Based Vital Signs Monitoring and Tracking System for Medical Parameters

    Directory of Open Access Journals (Sweden)

    Mr. Deshmukh Rohit Sunil

    2013-05-01

    Full Text Available Patients at a disaster scene can greatly benefit from technologies that continuously monitor their vital status and track their locations until they are admitted to the hospital. We have designed and developed a real-time patient monitoring system that integrates vital sign sensors, location sensor, ad-hoc networking, electronics patients status. This system shall facilitate communication between providers at a disaster scene, medical professionals at a local hospital, and specialists available for consultation from distant facilities

  19. The SSC cycle: a PDCA approach to address site-specific characteristics in a continuous shallow water quality monitoring project.

    Science.gov (United States)

    Miles, Eduardo J

    2008-05-01

    In any water quality-monitoring project there are several critical success factors that must be adequately addressed in order to ensure the implementation and realization of the monitoring objectives. Site selection is one of these critical success factors. The monitoring sites must be selected to comply with the monitoring and data quality objectives. In the real world, ideal monitoring setting conditions are difficult to achieve, and compromises must be made in order to locate the monitoring stations that best represent the environment to be monitored. Site-specific characteristics are all the environmental, logistical and management factors particular to the monitoring site, that could influence the fulfilment of the monitoring and data quality objectives. Therefore, during the site selection process, it is essential to properly consider and evaluate these site-specific characteristics. The SSC cycle was developed with this goal in mind, to assist the monitoring team to systematically address site-specific characteristics. The cycle is a methodology to organize the site-specific characteristics in different categories, and to ensure a comprehensive overview of these characteristics throughout the project life cycle.

  20. Likelihood updating of random process load and resistance parameters by monitoring

    DEFF Research Database (Denmark)

    Friis-Hansen, Peter; Ditlevsen, Ove Dalager

    2003-01-01

    . The numerical problem caused by these singularities is easily overcome by adding simulated low intensity white noise to the realization. Without changing its parameters the spectrum is hereby lifted above zero by an amount equal to the white noise intensity. The knowledge of an explicit likelihood function......, even though it is of complicated mathematical form, allows an approximate Bayesian updating and control of the time development of the parameters. Some of these parameters can be structural parameters that by too much change reveal progressing damage or other malfunctioning. Thus current process...

  1. Reconstruction of lattice parameters and beam momentum distribution from turn-by-turn beam position monitor readings in circular accelerators

    Directory of Open Access Journals (Sweden)

    C. S. Edmonds

    2014-05-01

    Full Text Available In high chromaticity circular accelerators, rapid decoherence of the betatron motion of a particle beam can make the measurement of lattice and bunch values, such as Courant-Snyder parameters and betatron amplitude, difficult. A method for reconstructing the momentum distribution of a beam from beam position measurements is presented. Further analysis of the same beam position monitor data allows estimates to be made of the Courant-Snyder parameters and the amplitude of coherent betatron oscillation of the beam. The methods are tested through application to data taken on the linear nonscaling fixed field alternating gradient accelerator, EMMA.

  2. A strategy for “constraint-based” parameter specification for environmental models

    NARCIS (Netherlands)

    Gharari, S.; Shafiei, M.; Hrachowitz, M.; Fenicia, F.; Gupta, H.V.; Savenije, H.H.G.

    2013-01-01

    Many environmental systems models, such as conceptual rainfall-runoff models, rely on model calibration for parameter identification. For this, an observed output time series (such as runoff) is needed, but frequently not available. Here, we explore another way to constrain the parameter values of s

  3. Estimation of source parameters according to microseismic monitoring of the central part of the East-European platform

    Science.gov (United States)

    Besedina, Alina

    2016-04-01

    Microseismic monitoring of active fault allows one to quickly assess the seismicity of the study area. In platform conditions it requires more time to accumulate of representative data of occurrence of seismic endogenous events. The graphics repeatability, based on data from microseismic monitoring, correlate well with the dependence obtained during long-term regional observations. The focal parameters are assessed for sources of weak seismicity of the central part of East-European platform with the help of small-aperture array. Sensor bandwidth limitations can lead to underestimation of radiated seismic energy due to losses in high-frequency part of signal. Seismometers with enhance amplitude-frequency response in high-frequency part of the spectrum allow avoiding this instrumental problem. This provides records seismic oscillations from events with Mw ~ -2 - 1 and more correct estimation of seismic source parameters. This work was supported by the Russian Foundation for Basic Research (project no. 16-35-00508).

  4. Evaluation of a Multi-Parameter Sensor for Automated, Continuous Cell Culture Monitoring in Bioreactors

    Science.gov (United States)

    Pappas, D.; Jeevarajan, A.; Anderson, M. M.

    2004-01-01

    Compact and automated sensors are desired for assessing the health of cell cultures in biotechnology experiments in microgravity. Measurement of cell culture medium allows for the optirn.jzation of culture conditions on orbit to maximize cell growth and minimize unnecessary exchange of medium. While several discrete sensors exist to measure culture health, a multi-parameter sensor would simplify the experimental apparatus. One such sensor, the Paratrend 7, consists of three optical fibers for measuring pH, dissolved oxygen (p02), dissolved carbon dioxide (pC02) , and a thermocouple to measure temperature. The sensor bundle was designed for intra-arterial placement in clinical patients, and potentially can be used in NASA's Space Shuttle and International Space Station biotechnology program bioreactors. Methods: A Paratrend 7 sensor was placed at the outlet of a rotating-wall perfused vessel bioreactor system inoculated with BHK-21 (baby hamster kidney) cells. Cell culture medium (GTSF-2, composed of 40% minimum essential medium, 60% L-15 Leibovitz medium) was manually measured using a bench top blood gas analyzer (BGA, Ciba-Corning). Results: A Paratrend 7 sensor was used over a long-term (>120 day) cell culture experiment. The sensor was able to track changes in cell medium pH, p02, and pC02 due to the consumption of nutrients by the BHK-21. When compared to manually obtained BGA measurements, the sensor had good agreement for pH, p02, and pC02 with bias [and precision] of 0.02 [0.15], 1 mm Hg [18 mm Hg], and -4.0 mm Hg [8.0 mm Hg] respectively. The Paratrend oxygen sensor was recalibrated (offset) periodically due to drift. The bias for the raw (no offset or recalibration) oxygen measurements was 42 mm Hg [38 mm Hg]. The measured response (rise) time of the sensor was 20 +/- 4s for pH, 81 +/- 53s for pC02, 51 +/- 20s for p02. For long-term cell culture measurements, these response times are more than adequate. Based on these findings , the Paratrend sensor could

  5. Design and Development of Low Power Wireless Sensor System for Measurement and Monitoring of Bio-Medical Parameters

    Directory of Open Access Journals (Sweden)

    D. Vishnu Vardhan, K. Soundara Rajan, Y. Narasimha Murthy

    2013-07-01

    Full Text Available This paper presents the design and development of a low power embedded system for the measurement and monitoring of physiological parameters like body temperature, respiration, blood pressure and ECG. The design is developed around a low power microcontroller MSP430 from Texas Instruments. A wireless sensor module is used to transfer the data from microcontroller to the PC and a graphical user interface (GUI is developed to display the measured data in the graphical form.

  6. A Device for Fetal Monitoring by Means of Control Over Cardiovascular Parameters Based on Acoustic Data

    Science.gov (United States)

    Khokhlova, L. A.; Seleznev, A. I.; Zhdanov, D. S.; Zemlyakov, I. Yu; Kiseleva, E. Yu

    2016-01-01

    The problem of monitoring fetal health is topical at the moment taking into account a reduction in the level of fertile-age women's health and changes in the concept of perinatal medicine with reconsideration of live birth criteria. Fetal heart rate monitoring is a valuable means of assessing fetal health during pregnancy. The routine clinical measurements are usually carried out by the means of ultrasound cardiotocography. Although the cardiotocography monitoring provides valuable information on the fetal health status, the high quality ultrasound devices are expensive, they are not available for home care use. The recommended number of measurement is also limited. The passive and fully non-invasive acoustic recording provides an alternative low-cost measurement method. The article describes a device for fetal and maternal health monitoring by analyzing the frequency and periodicity of heart beats by means of acoustic signal received on the maternal abdomen. Based on the usage of this device a phonocardiographic fetal telemedicine system, which will allow to reduce the antenatal fetal mortality rate significantly due to continuous monitoring over the state of fetus regardless of mother's location, can be built.

  7. Design of a hybrid (wired/wireless) acquisition data system for monitoring of cultural heritage physical parameters in Smart Cities.

    Science.gov (United States)

    García Diego, Fernando-Juan; Esteban, Borja; Merello, Paloma

    2015-03-25

    Preventive conservation represents a working method and combination of techniques which helps in determining and controlling the deterioration process of cultural heritage in order to take the necessary actions before it occurs. It is acknowledged as important, both in terms of preserving and also reducing the cost of future conservation measures. Therefore, long-term monitoring of physical parameters influencing cultural heritage is necessary. In the context of Smart Cities, monitoring of cultural heritage is of interest in order to perform future comparative studies and load information into the cloud that will be useful for the conservation of other heritage sites. In this paper the development of an economical and appropriate acquisition data system combining wired and wireless communication, as well as third party hardware for increased versatility, is presented. The device allows monitoring a complex network of points with high sampling frequency, with wired sensors in a 1-wire bus and a wireless centralized system recording data for monitoring of physical parameters, as well as the future possibility of attaching an alarm system or sending data over the Internet. This has been possible with the development of three board's designs and more than 5000 algorithm lines. System tests have shown an adequate system operation.

  8. Simultaneous and independent multi-parameter monitoring with fault localization for DSP-based coherent communication systems.

    Science.gov (United States)

    Shen, Thomas Shun Rong; Lau, Alan Pak Tao; Yu, Changyuan

    2010-11-08

    Digital signal processing (DSP)-based coherent communications have become standard for future high-speed optical networks. Implementing DSP-based advanced algorithms for data detection requires much more detailed knowledge of the transmission link parameters, resulting in optical performance monitoring (OPM) being even more important for next generation systems. At the same time, the DSP platform also enables new strategies for OPM. In this paper, we propose the use of pilot symbols with alternating power levels and study the statistics of the received power and phase difference to simultaneously and independently monitor the carrier frequency offset between transmitter and receiver laser, laser linewidth, number of spans, fiber nonlinearity parameters as well as optical signal-to-noise ratio (OSNR) of a transmission link. Analytical predictions are verified by simulation results for systems with full chromatic dispersion (CD) compensation per span and 10% CD under-compensation per span. In addition, we show that by monitoring the changes in the statistics of the received pilot symbols during network operation, one can locate faults or OSNR degradations along a transmission link without additional monitoring equipments at intermediate nodes, which may be useful for more efficient dynamic routing and network management.

  9. Field Assessment and Specification Review for Roller-Integrated Compaction Monitoring Technologies

    Directory of Open Access Journals (Sweden)

    David J. White

    2011-01-01

    Full Text Available Roller-integrated compaction monitoring (RICM technologies provide virtually 100-percent coverage of compacted areas with real-time display of the compaction measurement values. Although a few countries have developed quality control (QC and quality assurance (QA specifications, broader implementation of these technologies into earthwork construction operations still requires a thorough understanding of relationships between RICM values and traditional in situ point test measurements. The purpose of this paper is to provide: (a an overview of two technologies, namely, compaction meter value (CMV and machine drive power (MDP; (b a comprehensive review of field assessment studies, (c an overview of factors influencing statistical correlations, (d modeling for visualization and characterization of spatial nonuniformity; and (e a brief review of the current specifications.

  10. Assessing the accuracy of subject-specific, muscle-model parameters determined by optimizing to match isometric strength.

    Science.gov (United States)

    DeSmitt, Holly J; Domire, Zachary J

    2016-12-01

    Biomechanical models are sensitive to the choice of model parameters. Therefore, determination of accurate subject specific model parameters is important. One approach to generate these parameters is to optimize the values such that the model output will match experimentally measured strength curves. This approach is attractive as it is inexpensive and should provide an excellent match to experimentally measured strength. However, given the problem of muscle redundancy, it is not clear that this approach generates accurate individual muscle forces. The purpose of this investigation is to evaluate this approach using simulated data to enable a direct comparison. It is hypothesized that the optimization approach will be able to recreate accurate muscle model parameters when information from measurable parameters is given. A model of isometric knee extension was developed to simulate a strength curve across a range of knee angles. In order to realistically recreate experimentally measured strength, random noise was added to the modeled strength. Parameters were solved for using a genetic search algorithm. When noise was added to the measurements the strength curve was reasonably recreated. However, the individual muscle model parameters and force curves were far less accurate. Based upon this examination, it is clear that very different sets of model parameters can recreate similar strength curves. Therefore, experimental variation in strength measurements has a significant influence on the results. Given the difficulty in accurately recreating individual muscle parameters, it may be more appropriate to perform simulations with lumped actuators representing similar muscles.

  11. A method for real-time condition monitoring of haul roads based on Bayesian parameter estimation

    CSIR Research Space (South Africa)

    Heyns, T

    2012-04-01

    Full Text Available and to the vehicles. A recent idea is that vehicle on-board data collection systems could be used to monitor haul roads on a real-time basis by means of vibration signature analysis. This paper proposes a methodology based on Bayesian regression to isolate the effect...

  12. Technical specifications for monitoring Community trends in zoonotic agents in foodstuffs and animal populations on request from EFSA

    DEFF Research Database (Denmark)

    Borck Høg, Birgitte; Chriél, Mariann; Korsgaard, Helle

    Technical specifications are proposed for the monitoring of temporal trends in zoonotic agents in animal and food populations at Community or Member State group level in the framework of Directive 2003/99/EC. Two types of trend monitoring are identified: trend watching, which covers general obser...

  13. Integrating Condition Indicators and Usage Parameters for Improved Spiral Bevel Gear Health Monitoring

    Science.gov (United States)

    Dempsey, Paula J.; Handschuh, Robert F.; Delgado, Irebert, R.

    2013-01-01

    The objective of this study was to illustrate the importance of combining Health Usage Monitoring Systems (HUMS) data with usage monitoring system data when detecting rotorcraft transmission health. Three gear sets were tested in the NASA Glenn Spiral Bevel Gear Fatigue Rig. Damage was initiated and progressed on the gear and pinion teeth. Damage progression was measured by debris generation and documented with inspection photos at varying torque values. A contact fatigue analysis was applied to the gear design indicating the effect temperature, load and reliability had on gear life. Results of this study illustrated the benefits of combining HUMS data and actual usage data to indicate progression of damage for spiral bevel gears.

  14. Individual and Contextual Parameters Associated with Adolescents' Domain Specific Self-Perceptions

    Science.gov (United States)

    Kokkinos, Constantinos M.; Hatzinikolaou, Stamatia

    2011-01-01

    The present study examined the role of adolescents' self-esteem and perceptions of family and classroom contexts on their domain specific self-perceptions. 345 Greek junior high school adolescents aged 14-16 completed measures of domain specific self-perceptions, self-esteem, parenting styles and classroom climate. Hierarchical regression analyses…

  15. TISSUE POLYPEPTIDE-SPECIFIC ANTIGEN - A DISCRIMINATIVE PARAMETER BETWEEN PROSTATE-CANCER AND BENIGN PROSTATIC HYPERTROPHY

    NARCIS (Netherlands)

    MARRINK, J; OOSTEROM, R; BONFRER, HMG; SCHRODER, FH; MENSINK, HJA

    1993-01-01

    The serum concentration of the cell proliferation marker TPS (tissue polypeptide-specific antigen) was compared with the tumour marker PSA (prostate specific antigen). PSA was found elevated in 50% of the benign prostatic hypertrophy (BPH) patients, in 88% of the patients with active prostate cancer

  16. Individual and Contextual Parameters Associated with Adolescents' Domain Specific Self-Perceptions

    Science.gov (United States)

    Kokkinos, Constantinos M.; Hatzinikolaou, Stamatia

    2011-01-01

    The present study examined the role of adolescents' self-esteem and perceptions of family and classroom contexts on their domain specific self-perceptions. 345 Greek junior high school adolescents aged 14-16 completed measures of domain specific self-perceptions, self-esteem, parenting styles and classroom climate. Hierarchical regression analyses…

  17. TISSUE POLYPEPTIDE-SPECIFIC ANTIGEN - A DISCRIMINATIVE PARAMETER BETWEEN PROSTATE-CANCER AND BENIGN PROSTATIC HYPERTROPHY

    NARCIS (Netherlands)

    MARRINK, J; OOSTEROM, R; BONFRER, HMG; SCHRODER, FH; MENSINK, HJA

    1993-01-01

    The serum concentration of the cell proliferation marker TPS (tissue polypeptide-specific antigen) was compared with the tumour marker PSA (prostate specific antigen). PSA was found elevated in 50% of the benign prostatic hypertrophy (BPH) patients, in 88% of the patients with active prostate cancer

  18. Low parameter model to monitor bottom hole pressure in vertical multiphase flow in oil production wells

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Ahmadi

    2016-09-01

    Full Text Available The importance of the flow patterns through petroleum production wells proved for upstream experts to provide robust production schemes based on the knowledge about flow behavior. To provide accurate flow pattern distribution through production wells, accurate prediction/representation of bottom hole pressure (BHP for determining pressure drop from bottom to surface play important and vital role. Nevertheless enormous efforts have been made to develop mechanistic approach, most of the mechanistic and conventional models or correlations unable to estimate or represent the BHP with high accuracy and low uncertainty. To defeat the mentioned hurdle and monitor BHP in vertical multiphase flow through petroleum production wells, inventive intelligent based solution like as least square support vector machine (LSSVM method was utilized. The evolved first-break approach is examined by applying precise real field data illustrated in open previous surveys. Thanks to the statistical criteria gained from the outcomes obtained from LSSVM approach, the proposed least support vector machine (LSSVM model has high integrity and performance. Moreover, very low relative deviation between the model estimations and the relevant actual BHP data is figured out to be less than 6%. The output gained from LSSVM model are closed the BHP while other mechanistic models fails to predict BHP through petroleum production wells. Provided solutions of this study explicated that implies of LSSVM in monitoring bottom-hole pressure can indicate more accurate monitoring of the referred target which can lead to robust design with high level of reliability for oil and gas production operation facilities.

  19. Site-specific Protocol for Monitoring Marsh Birds : Don Edwards San Francisco Bay and San Pablo Bay National Wildlife Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This site-specific survey protocol provides standardized methods for monitoring marsh birds and was designed for use by the U.S. Fish and Wildlife Service (USFWS) on...

  20. 78 FR 39968 - Flight Data Recorder Airplane Parameter Specification Omissions and Corrections

    Science.gov (United States)

    2013-07-03

    ... TRANSPORTATION Federal Aviation Administration 14 CFR Parts 91, 121 and 125 RIN 2120-AK27 Flight Data Recorder... for flight data recorders by correcting errors in recording rates in three different appendices. These... when the applicable flight data recorder parameter requirements were adopted, but which have...

  1. Supramaximal stimulation during intraoperative facial nerve monitoring as a simple parameter to predict early functional outcome after parotidectomy.

    Science.gov (United States)

    Mamelle, Elisabeth; Bernat, Isabelle; Pichon, Soizic; Granger, Benjamin; Sain-Oulhen, Charlotte; Lamas, Georges; Tankéré, Frédéric

    2013-07-01

    A supramaximal stimulation at 2 mA during intraoperative electromyographic (EMG) facial nerve monitoring appears to be a simple and effective parameter to predict immediate postoperative injury. To assess the role of systematic intraoperative facial nerve monitoring in predicting the early functional outcomes obtained after parotidectomy. Data were collected from patients who underwent parotidectomy. Intraoperative EMG monitoring of the facial nerve was performed by registering two parameters, event intensity (>100 μV) and amplitude of response after a supramaximal stimulation at 2 mA, at the beginning and end of gland removal. Early postoperative clinical functional facial nerve disorder was assessed at day 2. Overall, 50 patients were included and an early facial dysfunction was detected in 27 cases (54%). The maximal response amplitude after supramaximal stimulation at the trunk of the facial nerve was higher in patients with normal facial function compared with those with poor outcomes at the end of surgery (p stimulation thresholds, were indicative of a nerve conduction block and were significantly lower in the patient group with a poor outcome compared with the group with a normal facial outcome (p < 0.02).

  2. Automatic Monitoring of Criteria Pollutants and Meteorological Parameters in Boundary Sites of Mexico City under QA/QC Standards

    Science.gov (United States)

    Martínez, A.; Ramos, R.; Sánchez, A.; Retama, A.; Fentanes, O.; Muñoz, R.; Mar, B.; Ruiz, L. G.; Torres, R.; Torres, A.; Martínez, J.

    2007-05-01

    MILAGRO, an extensive air quality monitoring campaign, was conducted in the Mexico City Metropolitan Area (MCMA) during March 2006, in order to assess the air pollutants transport and their influence at regional and global scales. In support of this campaign a number of criteria pollutants and meteorological parameters measurements were conducted in boundary sites of the MCMA in order to determine the surface conditions in these transition sites. The boundary sites were selected based on results from previous studies, information provided systematically by the Mexico City Ambient Air Monitoring Network (Sistema de Monitoreo Atmosférico, SIMAT), pollutants trends and meteorological and climatic factors that participate in the dispersion and transport under different ventilation scenarios. Seven mobile units and two fixed stations were deployed for the continuous determination of criteria pollutants and meteorological parameters. In order to warranty the pollutants concentrations measurements' quality and comparability, calibrations and verifications were implemented at the designated monitoring sites. Data had been analyzed with statistical tools and comparisons were made against nearby SIMAT stations. Several interesting conclusions were achieved.

  3. Sensitivity of subject-specific models to Hill muscle-tendon model parameters in simulations of gait

    NARCIS (Netherlands)

    Carbone, Vincenzo; van der Krogt, Marjolein; Koopman, Hubertus F.J.M.; Verdonschot, Nicolaas Jacobus Joseph

    2016-01-01

    Subject-specific musculoskeletal (MS) models of the lower extremity are essential for applications such as predicting the effects of orthopedic surgery. We performed an extensive sensitivity analysis to assess the effects of potential errors in Hill muscle–tendon (MT) model parameters for each of

  4. Prostate-specific antigen density as a parameter for the prediction of positive lymph nodes at radical prostatectomy

    Directory of Open Access Journals (Sweden)

    Theocharis Yiakoumos

    2015-01-01

    Conclusion: The most widely used nomogram is of high value in therapy decision-making, although it remains an auxiliary means. Considering the performance of lymph node dissection, surgeons should be aware of the specifics of the applied nomogram. PSAD appears as a useful adjunctive parameter for preoperative prostate risk estimation and warrants further evaluation.

  5. Sensitivity of subject-specific models to Hill muscle-tendon model parameters in simulations of gait

    NARCIS (Netherlands)

    Carbone, V.; Krogt, M.M. van der; Koopman, H.F.J.M.; Verdonschot, N.J.

    2016-01-01

    Subject-specific musculoskeletal (MS) models of the lower extremity are essential for applications such as predicting the effects of orthopedic surgery. We performed an extensive sensitivity analysis to assess the effects of potential errors in Hill muscle-tendon (MT) model parameters for each of th

  6. Sensitivity of subject-specific models to Hill muscle-tendon model parameters in simulations of gait

    NARCIS (Netherlands)

    Carbone, Vincenzo; van der Krogt, Marjolein; Koopman, Hubertus F.J.M.; Verdonschot, Nicolaas Jacobus Joseph

    2016-01-01

    Subject-specific musculoskeletal (MS) models of the lower extremity are essential for applications such as predicting the effects of orthopedic surgery. We performed an extensive sensitivity analysis to assess the effects of potential errors in Hill muscle–tendon (MT) model parameters for each of th

  7. Genetic parameters for pathogen-specific mastitis resistance in Danish Holstein cattle

    DEFF Research Database (Denmark)

    Sørensen, Lars Peter; Madsen, P.; Mark, Thomas;

    2009-01-01

    . uberis, respectively. The heritabilities of groups of pathogen ranged from 0.053 to 0.087. Genetic correlations among the pathogen-specific mastitis traits ranged from 0.45 to 0.77. These estimates tended to be lowest for bacteria eliciting very different immune responses, which can be considered...... as the overall pleiotropic effect of genes affecting resistance to a specific pathogen, and highest for bacteria sharing characteritics regarding immune response. The genetic correlations between the groups of pathogens were high, 0.73 and 0.83. Results showed that the pathogen-specific traits used in this study......The objective of this study was to estimate heritabilities for and genetic correlations among different pathogen-specific mastitis traits. The traits were unspecific mastitis, which is all mastitis treatments regardless of the causative pathogen as well as mastitis caused by Streptococcus...

  8. Psychosocial trajectories of men monitoring prostate-specific antigen levels following surgery for prostate cancer.

    Science.gov (United States)

    Bailey, Donald E; Wallace Kazer, Meredith; Polascik, Thomas J; Robertson, Cary

    2014-07-01

    To describe the psychosocial trajectories of men treated surgically for prostate cancer after monitoring their prostate-specific antigen (PSA) levels until 24 months post-treatment. Descriptive longitudinal study. Urology clinic at Duke University Health System. 12 men diagnosed and treated for prostate cancer. Men were interviewed in their homes at baseline and at 24 months and via telephone at 6, 12, and 18 months. Scores from the Profile of Mood States, Mishel Uncertainty in Illness Scale, Self-Control Schedule, and Cantril's Ladder were entered into a database for analysis. Graphs of individual participants' scores were plotted. PSA values, mood state, cognitive reframing, impact of event, quality of life, illness uncertainty, and growth through uncertainty were measured. Three trajectories were identified (i.e., stable, unstable, and mixed) and graphed using a typological or health pattern approach. Monitoring PSA levels is critical for men treated for prostate cancer. This study provides preliminary data on the psychological trajectories of men during the first 24 months postprostatectomy. Rising PSA levels that are associated with the recurrence of disease can cause psychosocial distress among men with prostate cancer.

  9. Monitoring of Pathogen-Specific T-Cell Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation

    Science.gov (United States)

    Fuji, Shigeo; Kapp, Markus; Einsele, Hermann

    2013-01-01

    The clinical outcome after allogeneic hematopoietic stem cell transplantation (HSCT) has been significantly improved during the last decades with regard to the reduction in organ failure, infection, and severe acute graft-versus-host disease. However, severe complications due to infectious diseases are still one of the major causes of morbidity and mortality after allogeneic HSCT, in particular in patients receiving haploidentical HSCT or cord blood transplant due to a slow and often incomplete immune reconstitution. In order to improve the immune control of pathogens without an increased risk of alloreactivity, adoptive immunotherapy using highly enriched pathogen-specific T cells offers a promising approach. In order to identify patients who are at high risk for infectious diseases, several monitoring assays have been developed with potential for the guidance of immunosuppressive drugs and adoptive immunotherapy in clinical practice. In this article, we aim to give a comprehensive overview regarding current developments of T-cell monitoring techniques focusing on T cells against viruses and fungi. In particular, we will focus on rather simple, fast, non-labor-intensive, cellular assays which could be integrated in routine clinical screening approaches. PMID:24062744

  10. Echocardiographic Monitoring of Cardiac Parameters after Mitral Valve Replacement with the Preservation of Subvalvular Structures

    Institute of Scientific and Technical Information of China (English)

    Rasul Sadirhanovich Parpiyev; Mirdjamal Mirumarovich Zufarov; Khamidulla Amannullaevich Abdumadjivov; Sayora Abdullaeva; Khusan Gazihanovich Khalikulov

    2011-01-01

    @@ TO date many monitoring techniques have been used to determine the efficacy of surgical correction of mitral valve disease.The most common non-invasive method in use is echocardiography which can assess the myocardial and mitral valve function changes after mitral valve replacement procedures.In this study,we investigated the five-year follow-up echocardiographic results of 143 patients undergoing mitral valve replacement with preservation of subvalvuiar apparatus to analyze the recovery of myocardial and mitral valve functions.

  11. Determination of the Power Transformer Efficiency Monitoring the Electrical Insulation Parameters

    Directory of Open Access Journals (Sweden)

    Adrian Munteanu

    2009-12-01

    Full Text Available The paper presents the monitoring methods for the insulating state of power transformers. For a transformer with oil-paper insulation system the ageing curves was obtained using the criterion of insulating resistance, and the correction coefficients for directly obtained the real insulation resistance. All these measurements are realized on the same transformer with S = 250 MVA power and 400/110/20 kV voltages. Using graphical method, the lifetime of insulation, respectively, of transformer is possible to be quickly obtained.

  12. Application of Hotelling’s T{sup 2} charts in monitoring quality parameters in a drinking water supply system

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Mafalda T., E-mail: mafaldatcosta@gmail.com [UAberta, Portugal and Ministry of Economy, Portuguese Government (Canada); Carolino, Elisabete, E-mail: lizcarolino@gmail.com [ESTeSL-IPL, Research Group Environment and Health of ESTeSL-IPL (Portugal); Oliveira, Teresa A., E-mail: teresa.oliveira@uab.pt [DCeT - Universidade Aberta, and Center of Statistics and Applications of University of Lisbon (Portugal)

    2015-03-10

    In water supply systems with distribution networkthe most critical aspects of control and Monitoring of water quality, which generates crises system, are the effects of cross-contamination originated by the network typology. The classics of control of quality systems through the application of Shewhart charts are generally difficult to manage in real time due to the high number of charts that must be completed and evaluated. As an alternative to the traditional control systems with Shewhart charts, this study aimed to apply a simplified methodology of a monitoring plan quality parameters in a drinking water distribution, by applying Hotelling’s T{sup 2} charts and supplemented with Shewhart charts with Bonferroni limits system, whenever instabilities with processes were detected.

  13. Likelihood updating of random process load and resistance parameters by monitoring

    DEFF Research Database (Denmark)

    Friis-Hansen, Peter; Ditlevsen, Ove Dalager

    2003-01-01

    Spectral parameters for a stationary Gaussian process are most often estimated by Fourier transformation of a realization followed by some smoothing procedure. This smoothing is often a weighted least square fitting of some prespecified parametric form of the spectrum. In this paper it is shown...... that maximum likelihood estimation is a rational alternative to an arbitrary weighting for least square fitting. The derived likelihood function gets singularities if the spectrum is prescribed with zero values at some frequencies. This is often the case for models of technically relevant processes....... The numerical problem caused by these singularities is easily overcome by adding simulated low intensity white noise to the realization. Without changing its parameters the spectrum is hereby lifted above zero by an amount equal to the white noise intensity. The knowledge of an explicit likelihood function...

  14. ARH_Db_Tuner: The GUI Tool to Monitor and Diagnose the SGA Parameters Automatically

    Directory of Open Access Journals (Sweden)

    Hitesh KUMAR SHARMA

    2013-05-01

    Full Text Available Database administrators should be aware of resource usages to maintain database system performance. As database applications become more complex and diverse, managing database systems becomes too costly and prone to error. Autonomic database tuning becomes more important than ever. One of the major issues to address in regards to ORACLE database performance is the size of the database. The bulk of the information consists of a large number of records, contained in many tables, each ranging from thousands of rows. There are many factors that can have direct effects on the performance of the database. CPU, Memory, Network, Disk I/O are among other factors. In order to make a database up and run efficiently, each factor must be addresses carefully, and the best tuning strategy must be applied for optimum performance. ORACLE performance issues are complex, and for a DBA, there is a large number of values to monitor and examine in order to decide on best tuning strategy. The aim of the work behind this paper was to design and implement a Database Performance Tuning Measurement Toolkit for ORACLE Database Servers working on MS-Windows platforms. This system is called ARH_Db_Tuner*. This system is the advance version of ORACLE Performance Monitoring Toolkit [19] (OPMT for short. Some of the future aspects of OPMT have been implemented in ARH_Db_Tuner. It is used for testing, analysis and reporting of the database performance.

  15. Optimal Parameter Exploration for Online Change-Point Detection in Activity Monitoring Using Genetic Algorithms

    Directory of Open Access Journals (Sweden)

    Naveed Khan

    2016-10-01

    Full Text Available In recent years, smart phones with inbuilt sensors have become popular devices to facilitate activity recognition. The sensors capture a large amount of data, containing meaningful events, in a short period of time. The change points in this data are used to specify transitions to distinct events and can be used in various scenarios such as identifying change in a patient’s vital signs in the medical domain or requesting activity labels for generating real-world labeled activity datasets. Our work focuses on change-point detection to identify a transition from one activity to another. Within this paper, we extend our previous work on multivariate exponentially weighted moving average (MEWMA algorithm by using a genetic algorithm (GA to identify the optimal set of parameters for online change-point detection. The proposed technique finds the maximum accuracy and F_measure by optimizing the different parameters of the MEWMA, which subsequently identifies the exact location of the change point from an existing activity to a new one. Optimal parameter selection facilitates an algorithm to detect accurate change points and minimize false alarms. Results have been evaluated based on two real datasets of accelerometer data collected from a set of different activities from two users, with a high degree of accuracy from 99.4% to 99.8% and F_measure of up to 66.7%.

  16. Characterization of 4 years MagnetoTelluric monitoring data by studying the temporal behaviour of Alpha Stable Distribution Parameters

    Science.gov (United States)

    Siniscalchi, Agata; Romano, Gerardo; Barracano, Fabio; Balasco, Marianna; Tripaldi, Simona

    2017-04-01

    Analyzing a 4 years of a single site MT continuous monitoring data, a systematic variation of the MT transfer function estimates was observed in the [20-100 s] period range that was shown to be connected to the global geomagnetic activity, Ap index (Romano et al., 2014). The monitored period, from 2007 to 2011, includes the global minimum of solar activity which occurred in 2009 (low MT source amplitude). It was shown that the impedance robust estimations tend to stabilize when the Ap index exceed a value of 10. In order to exclude a possible dependence of the observed fluctuation on the presence of a local cultural noise source, for a shorter period ( 2 months) the monitoring data were also processed by using a remote site. Recently Chave (2012) demonstrated that MT data can be described by alpha stable distribution family that is characterized by four-parameters that must be empirically determined. The Gaussian distribution belongs to this family as a special case when one of the four parameter, α the tail thickness, is equal to 2. Following Chave (2016), MT data are typically stably distributed with the empirical observation that 0.8 ≤α ≤1.8. In order to better understand the observed dependence of the MT continuous monitoring on the global geomagnetic activity, here we present the results a re-analysis of the MT monitoring data with a two steps processing. In the first step, we characterize the time series of the Alpha Stable Distribution Parameters (ASDP) as obtained from the whole processing of the dataset with the aim of checking for possible connections between these last and the Ap index. In the second step, we estimate the ASDP by using only the samples which satisfy the mathematical range of existence of the normalized WAL (Weaver et al.,2000) considering these last as a diagnostic tool to detect which segments of the time series in the frequency domain are strongly contaminated by noise (WAL selection criterion). The comparison between the results

  17. Genetic parameters for pathogen-specific mastitis resistance in Danish Holstein Cattle

    DEFF Research Database (Denmark)

    Sørensen, L P; Madsen, P; Mark, T

    2009-01-01

    The objective of this study was to estimate heritabilities for and genetic correlations among different pathogen-specific mastitis traits. The traits were unspecific mastitis, which is all mastitis treatments regardless of the causative pathogen as well as mastitis caused by Streptococcus...... and 2006 were used in the analyses. Variances and covariances were estimated using uni- and bivariate threshold models via Gibbs sampling. Posterior means of heritabilities of pathogen-specific mastitis were lower than the heritability of unspecific mastitis, ranging from 0.035 to 0.076 for S. aureus and S....... uberis, respectively. The heritabilities of groups of pathogen ranged from 0.053 to 0.087. Genetic correlations among the pathogen-specific mastitis traits ranged from 0.45 to 0.77. These estimates tended to be lowest for bacteria eliciting very different immune responses, which can be considered...

  18. In vivo fluorescence lifetime imaging monitors binding of specific probes to cancer biomarkers.

    Directory of Open Access Journals (Sweden)

    Yasaman Ardeshirpour

    Full Text Available One of the most important factors in choosing a treatment strategy for cancer is characterization of biomarkers in cancer cells. Particularly, recent advances in Monoclonal Antibodies (MAB as primary-specific drugs targeting tumor receptors show that their efficacy depends strongly on characterization of tumor biomarkers. Assessment of their status in individual patients would facilitate selection of an optimal treatment strategy, and the continuous monitoring of those biomarkers and their binding process to the therapy would provide a means for early evaluation of the efficacy of therapeutic intervention. In this study we have demonstrated for the first time in live animals that the fluorescence lifetime can be used to detect the binding of targeted optical probes to the extracellular receptors on tumor cells in vivo. The rationale was that fluorescence lifetime of a specific probe is sensitive to local environment and/or affinity to other molecules. We attached Near-InfraRed (NIR fluorescent probes to Human Epidermal Growth Factor 2 (HER2/neu-specific Affibody molecules and used our time-resolved optical system to compare the fluorescence lifetime of the optical probes that were bound and unbound to tumor cells in live mice. Our results show that the fluorescence lifetime changes in our model system delineate HER2 receptor bound from the unbound probe in vivo. Thus, this method is useful as a specific marker of the receptor binding process, which can open a new paradigm in the "image and treat" concept, especially for early evaluation of the efficacy of the therapy.

  19. Recommended Methods for Monitoring Skeletal Health in Astronauts to Distinguish Specific Effects of Prolonged Spaceflight

    Science.gov (United States)

    Vasadi, Lukas J.; Spector, Elizabeth R.; Smith, Scott A.; Yardley, Gregory L.; Evans, Harlan J.; Sibonga, Jean D.

    2016-01-01

    NASA uses areal bone mineral density (aBMD) by dual-energy X-ray absorptiometry (DXA) to monitor skeletal health in astronauts after typical 180-day spaceflights. The osteoporosis field and NASA, however, recognize the insufficiency of DXA aBMD as a sole surrogate for fracture risk. This is an even greater concern for NASA as it attempts to expand fracture risk assessment in astronauts, given the complicated nature of spaceflight-induced bone changes and the fact that multiple 1-year missions are planned. In the past decade, emerging analyses for additional surrogates have been tested in clinical trials; the potential use of these technologies to monitor the biomechanical integrity of the astronaut skeleton will be presented. OVERVIEW: An advisory panel of osteoporosis policy-makers provided NASA with an evidence-based assessment of astronaut biomedical and research data. The panel concluded that spaceflight and terrestrial bone loss have significant differences and certain factors may predispose astronauts to premature fractures. Based on these concerns, a proposed surveillance program is presented which a) uses Quantitative Computed Tomography (QCT) scans of the hip to monitor the recovery of spaceflight-induced deficits in trabecular BMD by 2 years after return, b) develops Finite Element Models [FEM] of QCT data to evaluate spaceflight effect on calculated hip bone strength and c) generates Trabecular Bone Score [TBS] from serial DXA scans of the lumbar spine to evaluate the effect of age, spaceflight and countermeasures on this novel index of bone microarchitecture. SIGNIFICANCE: DXA aBMD is a widely-applied, evidence-based predictor for fractures but not applicable as a fracture surrogate for premenopausal females and males parameters is a limitation for assessing changes in bone integrity with and without countermeasures. Collective use of aBMD, TBS, QCT, and FEM analysis for astronaut surveillance could accommodate NASA's aggressive schedule for risk

  20. Analysis of a Kalman filter based method for on-line estimation of atmospheric dispersion parameters using radiation monitoring data

    DEFF Research Database (Denmark)

    Drews, Martin; Lauritzen, Bent; Madsen, Henrik

    2005-01-01

    A Kalman filter method is discussed for on-line estimation of radioactive release and atmospheric dispersion from a time series of off-site radiation monitoring data. The method is based on a state space approach, where a stochastic system equation describes the dynamics of the plume model...... parameters, and the observables are linked to the state variables through a static measurement equation. The method is analysed for three simple state space models using experimental data obtained at a nuclear research reactor. Compared to direct measurements of the atmospheric dispersion, the Kalman filter...... estimates are found to agree well with the measured parameters, provided that the radiation measurements are spread out in the cross-wind direction. For less optimal detector placement it proves difficult to distinguish variations in the source term and plume height; yet the Kalman filter yields consistent...

  1. Towards Detecting Swath Events in TerraSAR-X Time Series to Establish NATURA 2000 Grassland Habitat Swath Management as Monitoring Parameter

    Directory of Open Access Journals (Sweden)

    Iftikhar Ali

    2011-06-01

    Full Text Available Spatial monitoring tools are necessary to respond to the threat of global biodiversity loss. At the European scale, remote sensing tools for NATURA 2000 habitat monitoring have been requested by the European Commission to fulfill the obligations of the EU Habitats Directive. This paper introduces a method by which swath events in semi-natural grasslands can be detected from multi-temporal TerraSAR-X data. The investigated study sites represent rare and endangered habitats (NATURA 2000 codes 6410, 6510, located in the Döberitzer Heide nature conservation area west of Berlin. We analyzed a time series of 11 stripmap images (HH-polarization covering the vegetation period affected by swath (June to September 2010 at a constant 11-day acquisition rate. A swath detection rule was established to extract the swath events for the NATURA 2000 habitats as well as for six contrasting pasture sites not affected by swath. All swath events observed in the field were correctly allocated. The results indicate the potential to allocate semi-natural grassland swath events to 11-day-periods using TerraSAR-X time series. Since the conservation of semi-natural grassland habitats requires compliance with specific swath management rules, the detection of swath events may thus provide new parameters for the monitoring of NATURA 2000 grassland habitats.

  2. Genetic parameters of pathogen-specific incidence of clinical mastitis in dairy cows

    NARCIS (Netherlands)

    Haas, de Y.; Barkema, H.W.; Veerkamp, R.F.

    2002-01-01

    The objective of this study was to estimate heritabilities for and genetic correlations among different pathogen-specific mastitis traits. The traits were unspecific mastitis, which is all mastitis treatments regardless of the causative pathogen as well as mastitis caused by Streptococcus

  3. Specifics of the hail parameter measurements using the optical precipitation gauge

    Science.gov (United States)

    Kalchikhin, V. V.; Kobzev, A. A.; Korolkov, V. A.; Tikhomirov, A. A.

    2015-11-01

    There are specifics of use of the obtaining and analyzing precipitation particle shadow images method for the hail precipitation investigations. Descriptions of the method and operation of the new optical rain gauge measuring system are presented. There are estimations of the device capabilities and prospects of its use for measurement of hail characteristics.

  4. Stepped MS(All) Relied Transition (SMART): An approach to rapidly determine optimal multiple reaction monitoring mass spectrometry parameters for small molecules.

    Science.gov (United States)

    Ye, Hui; Zhu, Lin; Wang, Lin; Liu, Huiying; Zhang, Jun; Wu, Mengqiu; Wang, Guangji; Hao, Haiping

    2016-02-11

    Multiple reaction monitoring (MRM) is a universal approach for quantitative analysis because of its high specificity and sensitivity. Nevertheless, optimization of MRM parameters remains as a time and labor-intensive task particularly in multiplexed quantitative analysis of small molecules in complex mixtures. In this study, we have developed an approach named Stepped MS(All) Relied Transition (SMART) to predict the optimal MRM parameters of small molecules. SMART requires firstly a rapid and high-throughput analysis of samples using a Stepped MS(All) technique (sMS(All)) on a Q-TOF, which consists of serial MS(All) events acquired from low CE to gradually stepped-up CE values in a cycle. The optimal CE values can then be determined by comparing the extracted ion chromatograms for the ion pairs of interest among serial scans. The SMART-predicted parameters were found to agree well with the parameters optimized on a triple quadrupole from the same vendor using a mixture of standards. The parameters optimized on a triple quadrupole from a different vendor was also employed for comparison, and found to be linearly correlated with the SMART-predicted parameters, suggesting the potential applications of the SMART approach among different instrumental platforms. This approach was further validated by applying to simultaneous quantification of 31 herbal components in the plasma of rats treated with a herbal prescription. Because the sMS(All) acquisition can be accomplished in a single run for multiple components independent of standards, the SMART approach are expected to find its wide application in the multiplexed quantitative analysis of complex mixtures.

  5. The use of Landsat for monitoring water parameters in the coastal zone

    Science.gov (United States)

    Bowker, D. E.; Witte, W. G.

    1977-01-01

    Landsats 1 and 2 have been successful in detecting and quantifying suspended sediment and several other important parameters in the coastal zone, including chlorophyll, particles, alpha (light transmission), tidal conditions, acid and sewage dumps, and in some instances oil spills. When chlorophyll a is present in detectable quantities, however, it is shown to interfere with the measurement of sediment. The Landsat banding problem impairs the instrument resolution and places a requirement on the sampling program to collect surface data from a sufficiently large area. A sampling method which satisfies this condition is demonstrated.

  6. Visualization and on line monitoring of geometric parameters of beams at KSRS

    CERN Document Server

    Ioudin, L; Potlovsky, K; Rezvov, V

    2001-01-01

    On the basis of developed hardware and software we investigate the opportunity of on line registration of geometric parameters of low intensity SR beam and electron beams in single shot mode. Ionization and luminescence detectors form real optic image of a beam cross section. The image is registered by a TV camera, digitized and processed by a computer. Gray scale image and profiles of a beam are represented. Accumulation and statistic processing of the data give the possibility to increase the sensitivity of the hardware and to calculate the average position of the beam gravity center, dispersion and statistic uncertainty.

  7. Dolphins adjust species-specific frequency parameters to compensate for increasing background noise.

    Science.gov (United States)

    Papale, Elena; Gamba, Marco; Perez-Gil, Monica; Martin, Vidal Martel; Giacoma, Cristina

    2015-01-01

    An increase in ocean noise levels could interfere with acoustic communication of marine mammals. In this study we explored the effects of anthropogenic and natural noise on the acoustic properties of a dolphin communication signal, the whistle. A towed array with four elements was used to record environmental background noise and whistles of short-beaked common-, Atlantic spotted- and striped-dolphins in the Canaries archipelago. Four frequency parameters were measured from each whistle, while Sound Pressure Levels (SPL) of the background noise were measured at the central frequencies of seven one-third octave bands, from 5 to 20 kHz. Results show that dolphins increase the whistles' frequency parameters with lower variability in the presence of anthropogenic noise, and increase the end frequency of their whistles when confronted with increasing natural noise. This study provides the first evidence that the synergy among SPLs has a role in shaping the whistles' structure of these three species, with respect to both natural and anthropogenic noise.

  8. Cannabis use by individuals with multiple sclerosis: effects on specific immune parameters.

    Science.gov (United States)

    Sexton, Michelle; Cudaback, Eiron; Abdullah, Rehab A; Finnell, John; Mischley, Laurie K; Rozga, Mary; Lichtman, Aron H; Stella, Nephi

    2014-10-01

    Cannabinoids affect immune responses in ways that may be beneficial for autoimmune diseases. We sought to determine whether chronic Cannabis use differentially modulates a select number of immune parameters in healthy controls and individuals with multiple sclerosis (MS cases). Subjects were enrolled and consented to a single blood draw, matched for age and BMI. We measured monocyte migration isolated from each subject, as well as plasma levels of endocannabinoids and cytokines. Cases met definition of MS by international diagnostic criteria. Monocyte cell migration measured in control subjects and individuals with MS was similarly inhibited by a set ratio of phytocannabinoids. The plasma levels of CCL2 and IL17 were reduced in non-naïve cannabis users irrespective of the cohorts. We detected a significant increase in the endocannabinoid arachidonoylethanolamine (AEA) in serum from individuals with MS compared to control subjects, and no significant difference in levels of other endocannabinoids and signaling lipids irrespective of Cannabis use. Chronic Cannabis use may affect the immune response to similar extent in individuals with MS and control subjects through the ability of phytocannabinoids to reduce both monocyte migration and cytokine levels in serum. From a panel of signaling lipids, only the levels of AEA are increased in individuals with MS, irrespective of Cannabis use or not. Our results suggest that both MS cases and controls respond similarly to chronic Cannabis use with respect to the immune parameters measured in this study.

  9. CANNABIS USE BY INDIVIDUALS WITH MULTIPLE SCLEROSIS: EFFECTS ON SPECIFIC IMMUNE PARAMETERS

    Science.gov (United States)

    Sexton, Michelle; Cudaback, Eiron; Abdullah, Rehab A.; Finnell, John; Mischley, Laurie K; Rozga, Mary; Lichtman, Aron H.; Stella, Nephi

    2014-01-01

    Cannabinoids affect immune responses in ways that may be beneficial for autoimmune diseases. We sought to determine whether chronic Cannabis use differentially modulates a select number of immune parameters in healthy controls and individuals with multiple sclerosis (MS cases). Subjects were enrolled and consented to a single blood draw, matched for age and BMI. We measured monocyte migration isolated from each subject, as well as plasma levels of endocannabinoids and cytokines. Cases met definition of MS by international diagnostic criteria. Monocyte cell migration measured in control subjects and individuals with MS were similarly inhibited by a set ratio of phytocannabinoids. The plasma levels of CCL2 and IL17 were reduced in non-naïve cannabis users irrespective of the cohorts. We detected a significant increase in the endocannabinoid arachidonoylethanolamine (AEA) in serum from individuals with MS compared to control subjects, and no significant difference in levels of other endocannabinoids and signaling lipids irrespective of Cannabis use. Chronic Cannabis use may affect the immune response to similar extent in individuals with MS and control subjects through the ability of phytocannabinoids to reduce both monocyte migration and cytokine levels in serum. From a panel of signaling lipids, only the levels of AEA are increased in individuals with MS, irrespective from Cannabis use or not. Our results suggest that both MS cases and controls respond similarly to chronic Cannabis use with respect to the immune parameters measured in this study. PMID:25135301

  10. Monitoring of WT1-specific cytotoxic T lymphocytes after allogeneic hematopoietic stem cell transplantation.

    Science.gov (United States)

    Morita, Yuriko; Heike, Yuji; Kawakami, Mami; Miura, Osamu; Nakatsuka, Shin-Ichi; Ebisawa, Michiko; Mori, Shin-Ichiro; Tanosaki, Ryuji; Fukuda, Takahiro; Kim, Sung-Won; Tobinai, Kensei; Takaue, Yoichi

    2006-09-15

    Donor-derived cytotoxic T lymphocytes (CTL) that respond to tumor antigens emerge after hematopoietic stem cell transplantation (HSCT), particularly in association with the status of immune recovery. To analyze the frequency of CTL against PR1, PRAME and WT1 after HSCT, a tetramer-based analysis was performed in 97 samples taken from 35 patients (9 AML, 11 MDS, 2 CML, 4 ALL, 7 lymphoma and 2 renal cell carcinoma [RCC]) with the HLA-A02 phenotype. Regarding PR1, only 1 sample showed the presence of tetramer-positive cells (0.04%/lymphocyte). Similarly, in PRAME, only 10 of 97 samples were sporadically positive with low titers. For WT1, positive results were detected in 39 of 97 samples and 7 (2 CML, 1 ALL, 2 lymphoma and 2 RCC) patients clearly showed positive results more than once. On the basis of these results, we performed serial analyses of WT1-specific CTL during the clinical course in 2 patients with RCC, who underwent HSCT with a reduced-intensity regimen, to examine the precise correlation between the kinetics of CTL, the occurrence of GVHD and the observed clinical response. A higher positive rate for WT1-specific CTL and a correlation with the clinical response suggest that WT1 may be a useful antigen for a wider monitoring application.

  11. Derivation of site-specific relationships between hydraulic parameters and p-wave velocities based on hydraulic and seismic tomography

    Energy Technology Data Exchange (ETDEWEB)

    Brauchler, R.; Doetsch, J.; Dietrich, P.; Sauter, M.

    2012-01-10

    In this study, hydraulic and seismic tomographic measurements were used to derive a site-specific relationship between the geophysical parameter p-wave velocity and the hydraulic parameters, diffusivity and specific storage. Our field study includes diffusivity tomograms derived from hydraulic travel time tomography, specific storage tomograms, derived from hydraulic attenuation tomography, and p-wave velocity tomograms, derived from seismic tomography. The tomographic inversion was performed in all three cases with the SIRT (Simultaneous Iterative Reconstruction Technique) algorithm, using a ray tracing technique with curved trajectories. The experimental set-up was designed such that the p-wave velocity tomogram overlaps the hydraulic tomograms by half. The experiments were performed at a wellcharacterized sand and gravel aquifer, located in the Leine River valley near Göttingen, Germany. Access to the shallow subsurface was provided by direct-push technology. The high spatial resolution of hydraulic and seismic tomography was exploited to derive representative site-specific relationships between the hydraulic and geophysical parameters, based on the area where geophysical and hydraulic tests were performed. The transformation of the p-wave velocities into hydraulic properties was undertaken using a k-means cluster analysis. Results demonstrate that the combination of hydraulic and geophysical tomographic data is a promising approach to improve hydrogeophysical site characterization.

  12. Monitoring Soil Moisture Deficit Effects on Vegetation Parameters Using Radiative Transfer Models Inversion and Hyperspectral Measurements Under Controlled Conditions

    Science.gov (United States)

    Bayat, Bagher; Van der Tol, Christiaan; Verhoef, Wouter

    2016-08-01

    Plant-available soil moisture is a key element which affects plant properties in their ecosystems. This study shows Poa pratensis -a species of grass- responses to soil moisture deficit during an artificial drought episode in a greenhouse experiment. We used radiative transfer model inversion to monitor the gradual manifestation of soil moisture deficit effects on vegetation in a laboratory setting. Plots of 21 cm x 14.5 cm surface area with Poa pratensis plants that formed a closed canopy were subjected to water stress for 40 days. In a regular weekly schedule, canopy reflectance was measured. The 1-D bidirectional canopy reflectance model SAIL, coupled with the leaf optical properties model PROSPECT, was inverted using hyperspectral measurements by means of an iterative optimization method to retrieve vegetation biophysical and biochemical parameters (mainly; LAI, Cab, Cw, Cdm and Cs). The relationships between these retrieved parameters with soil moisture content were established in two separated groups; stress and non-stressed. All parameters retrieved by model inversion using canopy spectral data showed good correlation with soil moisture content in the drought episode. These parameters co- varied with soil moisture content under the stress condition (Chl: R2= 0.91, Cw: R2= 0.97, Cs: R2= 0.88 and LAI: R2=0.48) at the canopy level.

  13. Individual and contextual parameters associated with adolescents' domain specific self-perceptions.

    Science.gov (United States)

    Kokkinos, Constantinos M; Hatzinikolaou, Stamatia

    2011-04-01

    The present study examined the role of adolescents' self-esteem and perceptions of family and classroom contexts on their domain specific self-perceptions. 345 Greek junior high school adolescents aged 14-16 completed measures of domain specific self-perceptions, self-esteem, parenting styles and classroom climate. Hierarchical regression analyses revealed that both family and classroom contexts predicted students' self-perceptions, after students' demographics, academic achievement and self-esteem were controlled for. However, different patterns emerged in the relationship between family, classroom climate and self-esteem depending on domain specific self-perceptions. Academic self-perceptions (scholastic, mathematics and language competences) were predicted by classroom climate dimensions (order and organization, student involvement, rule clarity), whereas self-perceptions regarding relations with parents, close friends and behaviour conduct, were predicted by parenting styles. Given the fact that adolescence is a period of fluctuation in self-understanding which renders self-perceptions particularly malleable, the results support the critical role of the social environments where adolescents operate.

  14. Environmental transportation of tritium and estimation of site-specific model parameters for Kaiga site, India.

    Science.gov (United States)

    Reji, T K; Ravi, P M; Ajith, T L; Dileep, B N; Hegde, A G; Sarkar, P K

    2012-04-01

    Tritium content in air moisture, soil water, rain water and plant water samples collected around the Kaiga site, India was estimated and the scavenging ratio, wet deposition velocity and ratio of specific activities of tritium between soil water and air moisture were calculated and the results are interpreted. Scavenging ratio was found to vary from 0.06 to 1.04 with a mean of 0.46. The wet deposition velocity of tritium observed in the present study was in the range of 3.3E-03 to 1.1E-02 m s(-1) with a mean of 6.6E-03 m s(-1). The ratio of specific activity of tritium in soil moisture to that in air moisture ranged from 0.17 to 0.95 with a mean of 0.49. The specific activity of tritium in plant water in this study varied from 73 to 310 Bq l(-1). The present study is very useful for understanding the process and modelling of transfer of tritium through air/soil/plant system at the Kaiga site.

  15. The effect of siesta in parameters of cardiac structure and in interpretation of ambulatory arterial blood pressure monitoring

    Directory of Open Access Journals (Sweden)

    Marco A.M. Gomes

    2000-04-01

    Full Text Available OBJECTIVE: To evaluate the influence of the siesta in ambulatory blood pressure (BP monitoring and in cardiac structure parameters. METHODS: 1940 ambulatory arterial blood pressure monitoring tests were analyzed (Spacelabs 90207, 15/15 minutes from 7:00 to 22:00 hours and 20/20 minutes from 22:01 to 6.59hours and 21% of the records indicated that the person had taken a siesta (263 woman, 52±14 years. The average duration of the siesta was 118±58 minutes. RESULTS: (average ± standard deviation The average of systolic/diastolic pressures during wakefulness, including the napping period, was less than the average for the period not including the siesta (138±16/85±11 vs 139±16/86±11 mmHg, p5%. CONCLUSION: The siesta influenced the heart structure parameters and from a statistical point of view the average of systolic and diastolic pressures and the respective pressure loads of the wakeful period.

  16. Monitoring of Interaction-Point Parameters Using the 3-Dimensional Luminosity Distribution Measured at PEP-II

    Energy Technology Data Exchange (ETDEWEB)

    Viaud, B.F.; /Montreal U.; Kozanecki, W.; /DAPNIA, Saclay; O' Grady, C.; Thompson, J.; Weaver, M.; /SLAC

    2006-07-28

    The 3-D luminosity distribution at the IP of the SLAC B-Factory is monitored using e{sup +}e{sup -} {yields} e{sup +}e{sup -}, {mu}{sup +}{mu}{sup -} events reconstructed online in the BABAR detector. The transverse centroid and spatial orientation of the luminosity ellipsoid reliably monitor IP orbit drifts. The longitudinal centroid is sensitive to small variations in the average relative RF phase of the beams and provides a detailed measurement of the phase transient along the bunch train. The longitudinal luminosity distribution depends on the e{sup +,-} overlap bunch length and the vertical IP {beta}-functions. Relative variations in horizontal luminous size are detectable at the micron level. In addition to continuous on-line monitoring of all the parameters above, we performed detailed studies of their variation along the bunch train to investigate a temporary luminosity degradation. We also compare {beta}*{sub y} measurements, collected over a year of high-luminosity operation, with HER and LER lattice functions measured by resonant transverse excitation. Our bunch-length measurements are consistent with those obtained by other methods and provide direct evidence for bunch-length modulation.

  17. Post Construction Green Infrastructure Performance Monitoring Parameters and Their Functional Components

    Directory of Open Access Journals (Sweden)

    Thewodros K. Geberemariam

    2016-12-01

    Full Text Available Drainage system infrastructures in most urbanized cities have reached or exceeded their design life cycle and are characterized by running with inadequate capacity. These highly degraded infrastructures are already overwhelmed and continued to impose a significant challenge to the quality of water and ecological systems. With predicted urban growth and climate change the situation is only going to get worse. As a result, municipalities are increasingly considering the concept of retrofitting existing stormwater drainage systems with green infrastructure practices as the first and an important step to reduce stormwater runoff volume and pollutant load inputs into combined sewer systems (CSO and wastewater facilities. Green infrastructure practices include an open green space that can absorb stormwater runoff, ranging from small-scale naturally existing pocket of lands, right-of-way bioswales, and trees planted along the sidewalk as well as large-scale public parks. Despite the growing municipalities’ interest to retrofit existing stormwater drainage systems with green infrastructure, few studies and relevant information are available on their performance and cost-effectiveness. Therefore, this paper aims to help professionals learn about and become familiar with green infrastructure, decrease implementation barriers, and provide guidance for monitoring green infrastructure using the combination of survey questionnaires, meta-narrative and systematic literature review techniques.

  18. Inversion of Source and Transport Parameters of Relativistic SEPs from Neutron Monitor Data

    Science.gov (United States)

    Agueda, Neus; Bütikofer, Rolf; Vainio, Rami; Heber, Bernd; Afanasiev, Alexander; Malandraki, Olga E.

    2016-04-01

    We present a new methodology to study the release processes of relativistic solar energetic particles (SEPs) based on the direct inversion of Ground Level Enhancements (GLEs) observed by the worldwide network of neutron monitors (NMs). The new approach makes use of several models, including: the propagation of relativistic SEPs from the Sun to the Earth, their transport in the Earth's magnetosphere and atmosphere, as well as the detection of the nucleon component of the secondary cosmic rays by ground based NMs. The combination of these models allows us to compute the expected ground-level NM counting rates for a series of instantaneous releases from the Sun. The amplitudes of the source components are then inferred by fitting the NM observations with the modeled NM counting rate increases. Within the HESPERIA project, we will develop the first software package for the direct inversion of GLEs and we will make it freely available for the solar and heliospheric communities. Acknowledgement: This work has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 637324.

  19. Monitoring of immunological parameters in adolescent basketball athletes during and after a sports season.

    Science.gov (United States)

    Brunelli, Diego Trevisan; Rodrigues, Ariel; Lopes, Wendell Arthur; Gáspari, Arthur Fernandes; Bonganha, Valéria; Montagner, Paulo César; Borin, João Paulo; Cavaglieri, Cláudia Regina

    2014-01-01

    The objective of the present study was to monitor the immunological and hormonal responses and the occurrence of upper respiratory symptoms in adolescent basketball athletes during the different stages of a sports season. Anthropometric measures, biochemical analyses (interleukin-6, interleukin-10, tumour necrosis factor-alpha, C-reactive protein, testosterone and cortisol), neuromuscular evaluations (standing vertical jumping ability, agility and estimated VO2max) and leukocyte counts were performed at four moments: 72 h before the season (-72 h); before the season (Pre-season); after six weeks, at the end of the preparatory period (Preparatory); and after 20 weeks, at the end of the competitive period (Competitive). Also, the occurrence of upper respiratory symptoms was collected weekly during all stages of the season. There were significant increases in monocytes, cortisol, tumour necrosis factor-alpha and C-reactive protein at the Competitive moment as compared to the Pre-season. In addition, interleukin-10 decreased at the Competitive moment as compared to the Pre-season. Occurrence of upper respiratory symptoms demonstrated increases (38%) during the competitive period as compared to the preparatory. These results suggest that periods of training and competition could increase the occurrence of upper respiratory symptoms in adolescent athletes and this may be due to the unwanted effects of an inflammatory process in response to the excessive stress of training and competition.

  20. Monitoring hemostasis parameters in left ventricular assist device recipients – a preliminary report

    Science.gov (United States)

    Kaczmarski, Jacek; Pacholewicz, Jerzy; Zakliczyński, Michał; Gąsior, Mariusz; Zembala, Marian

    2016-01-01

    Introduction Mechanical circulatory support (MCS) therapy is associated with the improvement of long-term prognosis in patients with end-stage heart failure. For years it has been used as a bridge to transplant. However, more recently it is even being used as a destination therapy. Recently, clinicians have identified common MCS therapy-associated complications: pump thrombosis, bleeding, and hemolysis. These complications are very challenging with regard to both diagnosis and management. Aim To determine time-dependant changes of selected hemostasis/coagulation parameters in patients with end-stage heart failure treated with MCS and antithrombotic therapy. Material and methods Sixteen patients with end-stage heart failure on left ventricular assist device (LVAD) were followed for 6 weeks (six blood samples for each patient). Every week an extended hemostasis panel was assessed, including activated partial thromboplastin time, prothrombin time, international normalized ratio, von Willebrand factor (vWF) activity, factor VIII activity, fibrinogen level, D-dimer, platelet response to arachidonic acid (ASPI test) and adenosine diphosphate (ADP test), thrombin receptor activating peptide-6 (TRAP test) and collagen (COL test). Results The study population comprised 16 men. The median time from LVAD implantation was 120 days (100–150 days). During the study period the D-dimer and fibrinogen concentrations were elevated but remained similar throughout all six measurements. Meanwhile factor VIII and vWF activities were elevated in the first two measurements and then subsequently declined. Inhibition of platelet aggregation was greater early after LVAD implantation. During subsequent weeks the inhibition of platelet aggregation was less pronounced. No patient developed any bleeding or thrombo-embolic event during the study period. Conclusions Patients on MCS therapy demonstrate significant time-dependant changes in hemostasis parameters (both in the coagulation system and

  1. An integrated process analytical technology (PAT) approach to monitoring the effect of supercooling on lyophilization product and process parameters of model monoclonal antibody formulations.

    Science.gov (United States)

    Awotwe Otoo, David; Agarabi, Cyrus; Khan, Mansoor A

    2014-07-01

    The aim of the present study was to apply an integrated process analytical technology (PAT) approach to control and monitor the effect of the degree of supercooling on critical process and product parameters of a lyophilization cycle. Two concentrations of a mAb formulation were used as models for lyophilization. ControLyo™ technology was applied to control the onset of ice nucleation, whereas tunable diode laser absorption spectroscopy (TDLAS) was utilized as a noninvasive tool for the inline monitoring of the water vapor concentration and vapor flow velocity in the spool during primary drying. The instantaneous measurements were then used to determine the effect of the degree of supercooling on critical process and product parameters. Controlled nucleation resulted in uniform nucleation at lower degrees of supercooling for both formulations, higher sublimation rates, lower mass transfer resistance, lower product temperatures at the sublimation interface, and shorter primary drying times compared with the conventional shelf-ramped freezing. Controlled nucleation also resulted in lyophilized cakes with more elegant and porous structure with no visible collapse or shrinkage, lower specific surface area, and shorter reconstitution times compared with the uncontrolled nucleation. Uncontrolled nucleation however resulted in lyophilized cakes with relatively lower residual moisture contents compared with controlled nucleation. TDLAS proved to be an efficient tool to determine the endpoint of primary drying. There was good agreement between data obtained from TDLAS-based measurements and SMART™ technology. ControLyo™ technology and TDLAS showed great potential as PAT tools to achieve enhanced process monitoring and control during lyophilization cycles. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

  2. 40 CFR 75.11 - Specific provisions for monitoring SO2 emissions.

    Science.gov (United States)

    2010-07-01

    ... common stack. (c) Unit with no location for a flow monitor meeting siting requirements. Where no location... a flow monitor in either the stack or the ducts serving an affected unit or installation of a flow monitor in either the stack or ducts is demonstrated to the satisfaction of the Administrator to...

  3. Evaluation of parameters associated with monitoring in vivo of uranium isotopes in the lungs; Avaliacao de parametros associados a monitoracao in vivo de isotopos de uranio nos pulmoes

    Energy Technology Data Exchange (ETDEWEB)

    Juppa, Silvia P.; Lucena, Eder A.; Dantas, Bernardo M.; Dantas, Ana Leticia A., E-mail: adantas@ird.gov.br [Instiluto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Laboratorio de Monitoracao In Vivo. Divisao de Dosimetria

    2013-11-01

    The objective of this study is to evaluate the parameters associated with the technique of monitoring individuals exposed to uranium isotopes, aiming to optimize the technique and reduced uncertainties associated.

  4. S35: a new parameter in blood gas analysis for monitoring the systemic oxygenation.

    Science.gov (United States)

    Trouwborst, A; Tenbrinck, R; Van Woerkens, E C

    1990-01-01

    In the estimation of oxygen transport the term oxygen availability is used as the product of cardiac output and the arterial oxygen content (CaO2). Attempts can be made to modify the concept of oxygen availability by subtracting from the CaO2 the venous content at a critical PO2 as measured in mixed venous blood (Pv-O2), where oxygen diffusion into tissue becomes compromised and oxygen uptake (VO2) may decrease. The real arterial available oxygen content (CavlO2) can be calculated by estimating the saturation at the critical Pv-O2. For our concept S35 was chosen as such a dynamic baseline. Similar modification of oxygen extraction ratio (ERav) defined as VO2 divided by the real oxygen availability (O2av) should give, more than the classic ER, a realistic indices of oxygen availability in relation to oxygen consumption. It can be hypothesized that VO2 starts to decline when ERav is around 1.0. During isovolemic hemodilution VO2 started to drop when ERav reached 1.08 +/- 0.09. The S35 changed from 55.0 +/- 2.1% to 41.5 +/- 4.1%, correlated with changes in Pv-O2. A direct correlation was also found between the increase of the classic ER and the change in S35. We conclude that the S35, the CavlO2 and the ERav can be of value in monitoring the systemic oxygenation and that the concept also includes the effect of changes in oxyhemoglobin characteristics on oxygen delivery.

  5. Determination of kinetic parameters for monitoring source driven subcritical transmutation devices

    Energy Technology Data Exchange (ETDEWEB)

    Becker, Maarten

    2014-03-15

    ADS are considered as an option for the irradiation facility in partitioning and transmutation concepts for highly radioactive waste from spent nuclear fuel. Due to the hard neutron energy spectrum and the subcriticality of the reactor ADS provide a good compromise between transmutation performance and safety aspects. For the safe operation, but also for the overall optimization of the facility, the determination of the subcriticality level is essential. To investigate experimental methods in Pulsed Neutron Source (PNS) experiments for the determination of the subcriticality level the ADS experiment YALINA-Thermal is thoroughly analyzed in this work. The experiment has been performed from 2005-2010 in Minsk, Belarus. Most of the related experimental methods rely on point kinetic equations. This approach introduces two main approximations. Firstly, the point kinetic equation cannot describe the transition of the neutron distribution from the source operation to the source shutdown. After shutdown, the neutron population would redistribute to establish the fundamental decay mode. This violates the point kinetic assumption of neutron flux spectra constant in time. Secondly, to calculate kinetic parameters like the neutron mean generation time and the effective delayed neutron fraction the neutron flux distribution of the effective multiplication factor equation is typically used, which is equivalent to an artificial critical steady-state reactor. However, it is the time-dependence of the decay of the neutron populations including their redistribution in space and energy, which affects the analyzed kinetic parameters. Consequently, this work aims for the accurate simulation of these phenomena with particular emphasis on the quality of the effective neutron cross sections. In this work new microscopic master libraries based on the JEFF 3.1, JEFF 3.1.1 and ENDF/B VII.0 evaluations are developed with a general purpose 350 energy groups structure for the deterministic

  6. Optimization of Stir Casting Process Parameters to Minimize the Specific Wear of Al-SiC Composites by Taguchi Method

    Directory of Open Access Journals (Sweden)

    Sadi

    2015-02-01

    Full Text Available The aim of this research is to optimize of stir casting process parameters to minimize the specific wear of Al-SiC composites by Taguchi method. Composite material used in this research was Al- Si aluminum alloy as the matrix and SiC (silicon carbide particles size 400 mesh as the reinforcement. Experimental design used L16 orthogonal arrays Taguchi method standards. Experimental factors used in the making of composite samples were SiC content, melt temperature, rotation speed and stirring duration, each with 4 levels or variations. The microstructures of Al-SiC composite were observed by scanning electron microscope (SEM. Experimental result showed that the optimum of stir casting process parameters are SiC content of 15 wt.%, melt temperature of 740 oC, rotation speed of 300 rpm and stirring duration of 10 minutes. The most significant parameter which affected on specific wear was SiC content which contributes 88.67%. Adding content of SiC from 0 to 15 wt. % can decrease the specific wear of Al-SiC composites about 90.08 %.

  7. Monitoring Of Air Quality Parameters For Construction Of Fire Risk Detection Systems

    Science.gov (United States)

    Romancov, I. I.; Dashkovky, A. G.; Panin, V. F.; Melkov, D. N.

    2017-01-01

    The analysis of fire developmental process is given, which showed that there are seven stages of fire development, a set of phenomena (factors, signs) of fire risk condition, characterized by a set of defined parameters, corresponds to each stage. Observed that the registration of high staging factors (high ambient temperature, content of CO2, etc.) means the registration of actual low staging fire (thermal destruction of materials gases, fumes, etc.) - fire risk situation. It is shown that the decrease of registered factor staging leads to construction of fire preventive and diagnostic systems as the lower is registered stage, the more uncertain is connection between the fact of its detection and a fire. It is indicated that with development of electronic equipment the staging of fire situations factors used for detection is reducing in whole, and also it is noted that for each control object it is necessary to choose (identify) the optimal factor, in particular, in many ways the optimal factor for aircrafts are smokes and their TV image.

  8. Monitoring the water microbial parameters of some lakes of Lura Park

    Directory of Open Access Journals (Sweden)

    ANDREJEVA GOLLOSHI

    2014-06-01

    Full Text Available Lura Park with surface of 1,280 hectares is located in northern Albania, in the eastern part of the massive mountain Lura Crown. This park has 14 glacial lakes, located at the height of 1350-1720 meters that create a colorful and attractive environment. In winter these lakes are covered by ice. The largest lake is the Great Lake with an area of 32 hectares. But in almost all the lakes the natural balance is broken, as a result of demographic changes of region and usage without any criteria of the vegetation around the lakes. Disposal of inert materials and solid waste, as well as those of liquid in many water environments of Lura, has damaged their appearance and quality. It is appreciated the quality of some lakes of Lura in different points, with microbial parameters in determining the total number of microorganisms (HET and the presence of coliforms and by comparing them with international norms allowed for surface waters. The results obtained, showed low levels of coliforms in the water lakes, which is within the limits allowed. The greater this contamination was observed during summer, and less in the winter.

  9. Normative Spatiotemporal Parameters During 100-m Sprints in Amputee Sprinters Using Running-Specific Prostheses.

    Science.gov (United States)

    Hobara, Hiroaki; Potthast, Wolfgang; Müller, Ralf; Kobayashi, Yoshiyuki; Heldoorn, Thijs A; Mochimaru, Masaaki

    2016-02-01

    The aim of this study was to develop a normative sample of step frequency and step length during maximal sprinting in amputee sprinters. We analyzed elite-level 100-m races of 255 amputees and 93 able-bodied sprinters, both men and women, from publicly-available Internet broadcasts. For each sprinter's run, the average forward velocity, step frequency, and step length over the 100-m distance were analyzed by using the official record and number of steps in each race. The average forward velocity was greatest in able-bodied sprinters (10.04 ± 0.17 m/s), followed by bilateral transtibial (8.77 ± 0.27 m/s), unilateral transtibial (8.65 ± 0.30 m/s), and transfemoral amputee sprinters (7.65 ± 0.38 m/s) in men. Differences in velocity among 4 groups were associated with step length (able-bodied vs transtibial amputees) or both step frequency and step length (able-bodied vs transfemoral amputees). Although we also found that the velocity was greatest in able-bodied sprinters (9.10 ± 0.14 m/s), followed by unilateral transtibial (7.08 ± 0.26 m/s), bilateral transtibial (7.06 ± 0.48 m/s), and transfemoral amputee sprinters (5.92 ± 0.33 m/s) in women, the differences in the velocity among the groups were associated with both step frequency and step length. Current results suggest that spatiotemporal parameters during a 100-m race of amputee sprinters is varied by amputation levels and sex.

  10. Use of simple hematological, biochemical and clinical parameters to monitor response of multiple myeloma patients on high dose thalidomide therapy

    Directory of Open Access Journals (Sweden)

    Uppal G

    2005-01-01

    Full Text Available BACKGROUND: Evidence of increased bone marrow vascularity in multiple myeloma (MM has led to the use of anti-angiogenic drugs especially thalidomide in relapsed or refractory patients. Currently, parameters such as serum/ urine electrophoresis for M (monoclonal proteins, bone marrow biopsy with touch preparation and b2 microglobulin are routinely used to assess response to therapy. These investigations are expensive, invasive and require high technical setup. AIM: To correlate simple and routine hematological and biochemical parameters with the key marker of disease i.e. M proteins. SETTINGS AND DESIGN: This is an open label, uncontrolled, single-arm study. MATERIALS AND METHODS: Twenty nine refractory or relapsed multiple myeloma patients of both sexes (M=20, F=9 with age ranging between 35-72 years were initiated on 200 mg/day of thalidomide with fortnightly increments of 200 mg to a maximum tolerated dose not exceeding 800 mg/day. All hematological and biochemical parameters were monitored at monthly intervals for one year. STATISTICAL ANALYSIS: Correlation analysis was performed between hemoglobin (Hb, total leukocyte count (TLC, absolute neutrophil count (ANC, platelet count (PC, total proteins (TP, serum albumin and serum globulin on one hand and M protein levels on the other using Pearsons Correlation test by SPSS version 7.5. RESULT: Hb, TLC, ANC, PC and serum albumin levels showed a significant negative correlation with M proteins. A highly significant positive correlation existed between M proteins on one hand and TP and globulin levels on the other. Dryness of skin indicated positive response to therapy. These correlations were found to be significant at the end of one month of therapy in all the above-mentioned parameters except in TLC where it was significant after 2 months of thalidomide therapy. CONCLUSION: Results suggest that sustained efficacy of thalidomide therapy may be amenable to monitoring by these simple, inexpensive and

  11. Variability in the microcanonical cascades parameters among gauges of urban precipitation monitoring network

    Science.gov (United States)

    Licznar, Paweł; Rupp, David; Adamowski, Witold

    2013-04-01

    In the fall of 2008, Municipal Water Supply and Sewerage Company (MWSSC) in Warsaw began operating the first large precipitation monitoring network dedicated to urban hydrology in Poland. The process of establishing the network as well as the preliminary phase of its operation, raised a number of questions concerning optimal gauge location and density and revealed the urgent need for new data processing techniques. When considering the full-field precipitation as input to hydrodynamic models of stormwater and combined sewage systems, standard processing techniques developed previously for single gauges and concentrating mainly on the analysis of maximum rainfall rates and intensity-duration-frequency (IDF) curves development were found inadequate. We used a multifractal rainfall modeling framework based on microcanonical multiplicative random cascades to analyze properties of Warsaw precipitation. We calculated breakdown coefficients (BDC) for the hierarchy of timescales from λ=1 (5-min) up to λ=128 (1280-min) for all 25 gauges in the network. At small timescales histograms of BDCs were strongly deformed due to the recording precision of rainfall amounts. A randomization procedure statistically removed the artifacts due to precision errors in the original series. At large timescales BDC values were sparse due to relatively short period of observations (2008-2011). An algorithm with a moving window was proposed to increase the number of BDC values at large timescales and to smooth their histograms. The resulting empirical BDC histograms were modeled by a theoretical "2N-B" distribution, which combined 2 separate normal (N) distributions and one beta (B) distribution. A clear evolution of BDC histograms from a 2N-B distribution for small timescales to a N-B distributions for intermediate timescales and finally to a single beta distributions for large timescales was observed for all gauges. Cluster analysis revealed close patterns of BDC distributions among almost

  12. Genetic and phenotypic parameters estimated from Nebraska specific-pathogen-free swine field records.

    Science.gov (United States)

    David, P J; Johnson, R K; Socha, T E

    1983-11-01

    Records collected during 1971 through 1979 from 101,606 hogs raised in 18 Nebraska Specific Pathogen Free herds were analyzed. Traits considered were backfat at 100 kg (BF), weight at 140 d of age (WT) and, in some analyses, number of live pigs/litter at birth (NBA). The phenotypic correlation of BF and WT, averaged across herds, was -.07. The correlations between BF and NBA and between WT and NBA were .04 and -.05, respectively. Average phenotypic standard deviations for BF, WT and NBA were 2.6 mm, 8.8 kg and 2.0 pigs. Estimates of the heritability of BF and WT were lower than most estimates reported from university research herds. Within breed, herd and sex estimates of heritability ranged from -.22 and .51 (unweighted mean = .16 +/- .025) for BF and ranged from -.28 to .49 (mean = .16 +/- .016) for WT. Estimates of the genetic correlation between BF and WT were extremely variable (mean = -.62 +/- 14.3, range = -9.42 to 1.30) among breed-herd-sex subclasses.

  13. GPS radio occultation with CHAMP and SAC-C: global monitoring of thermal tropopause parameters

    Directory of Open Access Journals (Sweden)

    T. Schmidt

    2005-01-01

    Full Text Available In this study the global lapse-rate tropopause (LRT pressure, temperature, potential temperature, and sharpness are discussed based on Global Positioning System (GPS radio occultations (RO from the German CHAMP (CHAllenging Minisatellite Payload and the U.S.-Argentinian SAC-C (Satelite de Aplicaciones Cientificas-C satellite missions. Results with respect to seasonal variations are compared with operational radiosonde data and ECMWF (European Centre for Medium-Range Weather Forecast operational analyses. Results on the tropical quasi-biennial oscillation (QBO are updated from an earlier study. CHAMP RO data are available continuously since May 2001 with on average 150 high resolution temperature profiles per day. SAC-C data are available for several periods in 2001 and 2002. In this study temperature data from CHAMP for the period May 2001-December 2004 and SAC-C data from August 2001-October 2001 and March 2002-November 2002 were used, respectively. The bias between GPS RO temperature profiles and radiosonde data was found to be less than 1.5K between 300 and 10hPa with a standard deviation of 2-3K. Between 200-20hPa the bias is even less than 0.5K (2K standard deviation. The mean deviations based on 167699 comparisons between CHAMP/SAC-C and ECMWF LRT parameters are (-2.1±37.1hPa for pressure and (0.1±4.2K for temperature. Comparisons of LRT pressure and temperature between CHAMP and nearby radiosondes (13230 resulted in (5.8±19.8hPa and (-0.1±3.3K, respectively. The comparisons between CHAMP/SAC-C and ECMWF show on average the largest differences in the vicinity of the jet streams with up to 700m in LRT altitude and 3K in LRT temperature, respectively. The CHAMP mission generates the first long-term RO data set. Other satellite missions will follow (GRACE, COSMIC, MetOp, TerraSAR-X, EQUARS generating together some thousand temperature profiles daily.

  14. Effect of Operating Parameters and Chemical Additives on Crystal Habit and Specific Cake Resistance of Zinc Hydroxide Precipitates

    Energy Technology Data Exchange (ETDEWEB)

    Alwin, Jennifer Louise [New Mexico State Univ., Las Cruces, NM (United States)

    1999-08-01

    The effect of process parameters and chemical additives on the specific cake resistance of zinc hydroxide precipitates was investigated. The ability of a slurry to be filtered is dependent upon the particle habit of the solid and the particle habit is influenced by certain process variables. The process variables studied include neutralization temperature, agitation type, and alkalinity source used for neutralization. Several commercially available chemical additives advertised to aid in solid/liquid separation were also examined in conjunction with hydroxide precipitation. A statistical analysis revealed that the neutralization temperature and the source of alkalinity were statistically significant in influencing the specific cake resistance of zinc hydroxide precipitates in this study. The type of agitation did not significantly effect the specific cake resistance of zinc hydroxide precipitates. The use of chemical additives in conjunction with hydroxide precipitation had a favorable effect on the filterability. The morphology of the hydroxide precipitates was analyzed using scanning electron microscopy.

  15. HadISDH: an updateable land surface specific humidity product for climate monitoring

    Directory of Open Access Journals (Sweden)

    K. M. Willett

    2013-03-01

    Full Text Available HadISDH is a near-global land surface specific humidity monitoring product providing monthly means from 1973 onwards over large-scale grids. Presented herein to 2012, annual updates are anticipated. HadISDH is an update to the land component of HadCRUH, utilising the global high-resolution land surface station product HadISD as a basis. HadISD, in turn, uses an updated version of NOAA's Integrated Surface Database. Intensive automated quality control has been undertaken at the individual observation level, as part of HadISD processing. The data have been subsequently run through the pairwise homogenisation algorithm developed for NCDC's US Historical Climatology Network monthly temperature product. For the first time, uncertainty estimates are provided at the grid-box spatial scale and monthly timescale. HadISDH is in good agreement with existing land surface humidity products in periods of overlap, and with both land air and sea surface temperature estimates. Widespread moistening is shown over the 1973–2012 period. The largest moistening signals are over the tropics with drying over the subtropics, supporting other evidence of an intensified hydrological cycle over recent years. Moistening is detectable with high (95% confidence over large-scale averages for the globe, Northern Hemisphere and tropics, with trends of 0.089 (0.080 to 0.098 g kg−1 per decade, 0.086 (0.075 to 0.097 g kg−1 per decade and 0.133 (0.119 to 0.148 g kg−1 per decade, respectively. These changes are outside the uncertainty range for the large-scale average which is dominated by the spatial coverage component; station and grid-box sampling uncertainty is essentially negligible on large scales. A very small moistening (0.013 (−0.005 to 0.031 g kg−1 per decade is found in the Southern Hemisphere, but it is not significantly different from zero and uncertainty is large. When globally averaged, 1998 is the moistest year since monitoring began in 1973, closely

  16. HadISDH: an updateable land surface specific humidity product for climate monitoring

    Science.gov (United States)

    Willett, K. M.; Williams, C. N., Jr.; Dunn, R. J. H.; Thorne, P. W.; Bell, S.; de Podesta, M.; Jones, P. D.; Parker, D. E.

    2013-03-01

    HadISDH is a near-global land surface specific humidity monitoring product providing monthly means from 1973 onwards over large-scale grids. Presented herein to 2012, annual updates are anticipated. HadISDH is an update to the land component of HadCRUH, utilising the global high-resolution land surface station product HadISD as a basis. HadISD, in turn, uses an updated version of NOAA's Integrated Surface Database. Intensive automated quality control has been undertaken at the individual observation level, as part of HadISD processing. The data have been subsequently run through the pairwise homogenisation algorithm developed for NCDC's US Historical Climatology Network monthly temperature product. For the first time, uncertainty estimates are provided at the grid-box spatial scale and monthly timescale. HadISDH is in good agreement with existing land surface humidity products in periods of overlap, and with both land air and sea surface temperature estimates. Widespread moistening is shown over the 1973-2012 period. The largest moistening signals are over the tropics with drying over the subtropics, supporting other evidence of an intensified hydrological cycle over recent years. Moistening is detectable with high (95%) confidence over large-scale averages for the globe, Northern Hemisphere and tropics, with trends of 0.089 (0.080 to 0.098) g kg-1 per decade, 0.086 (0.075 to 0.097) g kg-1 per decade and 0.133 (0.119 to 0.148) g kg-1 per decade, respectively. These changes are outside the uncertainty range for the large-scale average which is dominated by the spatial coverage component; station and grid-box sampling uncertainty is essentially negligible on large scales. A very small moistening (0.013 (-0.005 to 0.031) g kg-1 per decade) is found in the Southern Hemisphere, but it is not significantly different from zero and uncertainty is large. When globally averaged, 1998 is the moistest year since monitoring began in 1973, closely followed by 2010, two strong El

  17. Monitoring Different Phonological Parameters of Sign Language Engages the Same Cortical Language Network but Distinctive Perceptual Ones.

    Science.gov (United States)

    Cardin, Velia; Orfanidou, Eleni; Kästner, Lena; Rönnberg, Jerker; Woll, Bencie; Capek, Cheryl M; Rudner, Mary

    2016-01-01

    The study of signed languages allows the dissociation of sensorimotor and cognitive neural components of the language signal. Here we investigated the neurocognitive processes underlying the monitoring of two phonological parameters of sign languages: handshape and location. Our goal was to determine if brain regions processing sensorimotor characteristics of different phonological parameters of sign languages were also involved in phonological processing, with their activity being modulated by the linguistic content of manual actions. We conducted an fMRI experiment using manual actions varying in phonological structure and semantics: (1) signs of a familiar sign language (British Sign Language), (2) signs of an unfamiliar sign language (Swedish Sign Language), and (3) invented nonsigns that violate the phonological rules of British Sign Language and Swedish Sign Language or consist of nonoccurring combinations of phonological parameters. Three groups of participants were tested: deaf native signers, deaf nonsigners, and hearing nonsigners. Results show that the linguistic processing of different phonological parameters of sign language is independent of the sensorimotor characteristics of the language signal. Handshape and location were processed by different perceptual and task-related brain networks but recruited the same language areas. The semantic content of the stimuli did not influence this process, but phonological structure did, with nonsigns being associated with longer RTs and stronger activations in an action observation network in all participants and in the supramarginal gyrus exclusively in deaf signers. These results suggest higher processing demands for stimuli that contravene the phonological rules of a signed language, independently of previous knowledge of signed languages. We suggest that the phonological characteristics of a language may arise as a consequence of more efficient neural processing for its perception and production.

  18. [The peripheral perfusion pressure: a new non-invasive parameter for the circulatory monitoring of patients (author's transl)].

    Science.gov (United States)

    Huch, A; Lübbers, D W; Huch, R

    1975-01-01

    Heating of a skin area to a temperature of 42 degrees to 44 degrees C produces a certain physiological condition which induces maximal vasodilatation. Detailed experiments have shown that local peripheral vascular resistance of such an area remains constant for several hours. The flow in this area is proportional to the actual perfusion pressure. Relative flow was measured by means of a new type of electrode fixed to the skin like and ECG electrode, and compared with simultaneous intra-arterial blood pressure measruements. The changes in arterial blood pressure were also recorded by the skin electrode. This new parameter is defined as "peripheral perfusion pressure". It is appropiate for non-invasive continuous monitoring of the circulatory system of patients.

  19. Structural correlation method for model reduction and practical estimation of patient specific parameters illustrated on heart rate regulation.

    Science.gov (United States)

    Ottesen, Johnny T; Mehlsen, Jesper; Olufsen, Mette S

    2014-11-01

    We consider the inverse and patient specific problem of short term (seconds to minutes) heart rate regulation specified by a system of nonlinear ODEs and corresponding data. We show how a recent method termed the structural correlation method (SCM) can be used for model reduction and for obtaining a set of practically identifiable parameters. The structural correlation method includes two steps: sensitivity and correlation analysis. When combined with an optimization step, it is possible to estimate model parameters, enabling the model to fit dynamics observed in data. This method is illustrated in detail on a model predicting baroreflex regulation of heart rate and applied to analysis of data from a rat and healthy humans. Numerous mathematical models have been proposed for prediction of baroreflex regulation of heart rate, yet most of these have been designed to provide qualitative predictions of the phenomena though some recent models have been developed to fit observed data. In this study we show that the model put forward by Bugenhagen et al. can be simplified without loss of its ability to predict measured data and to be interpreted physiologically. Moreover, we show that with minimal changes in nominal parameter values the simplified model can be adapted to predict observations from both rats and humans. The use of these methods make the model suitable for estimation of parameters from individuals, allowing it to be adopted for diagnostic procedures.

  20. TRACKING DYNAMIC CHANGES AND MONITORING SOCIOECONOMIC PARAMETERS IN ALGERIA BETWEEN 1993 AND 2012, USING NIGHTTIME LIGHT REMOTE SENSING

    Directory of Open Access Journals (Sweden)

    B. Faouzi

    2017-09-01

    Full Text Available This paper is based on using DMSP-OLS data from satellites nighttime light observations to detect both sources of light emissions in Algeria from human settlement areas and gas flaring from oil-extraction and natural gas production. We used the time series of data from DMSP-OLS images to examine the spatial and temporal characteristics of urban development in 48 Algerian provinces from 1993 to 2012. A systematic nighttime light calibration method was used to improve the consistency and comparability of the DSMPOSL images and then a separation is made between light detected from human settlements and light detected from gas flaring in order to allow us to study human settlements without other light emissions and then assess the suitability of using DMSP data in southern Algeria and its ability to monitor gas flaring. Linear regression methods were developed to identify the dynamic change of nighttime light and estimated its growth directions at pixel level. This work is the first to use nighttime light observations to detect and monitor the growth of human settlements in North Africa. In this study, we made use of DMSP-OLS data as a return ticket to the years of crises and we found the most affected provinces during that period. The DMSP-OLS data proved to be an index of growth in the economy during the period of stability in Algeria expressed by positive dynamic changes in the lighted area in all Algerian provinces. We used NTL data as an alternative to annual growth indexes for each province, which are unavailable, and its help as a monitoring system for socioeconomic parameters to fill the gap of data availability. We also proposed nighttime light remote sensing data as a useful tool to control and reduce CO2 emissions in Algeria’s petroleum sector.

  1. A New General Method for Simultaneous Fitting of Temperature- and Concentration-Dependence of Reaction Rates Yields Kinetic and Thermodynamic Parameters for HIV Reverse Transcriptase Specificity.

    Science.gov (United States)

    Li, An; Ziehr, Jessica L; Johnson, Kenneth A

    2017-03-02

    Recent studies have demonstrated the dominant role of induced-fit in enzyme specificity of HIV reverse transcriptase and many other enzymes. However, relevant thermodynamic parameters are lacking and equilibrium thermodynamic methods are of no avail because the key parameters can only determined by kinetic measurement. By modifying KinTek Explorer software, we present a new general method for globally fitting data collected over a range of substrate concentrations and temperatures and apply it to HIV reverse transcriptase. Fluorescence stopped-flow methods were used to record the kinetics of enzyme conformational changes that monitor nucleotide binding and incorporation. The nucleotide concentration dependence was measured at temperatures ranging from 5 to 37C and the raw data were fit globally to derive a single set of rate constants at 37C and a set of activation enthalpy terms to account for the kinetics at all other temperatures. This comprehensive analysis afforded thermodynamic parameters for nucleotide binding (Kd, ΔG, ΔH, ΔS at 37C), and kinetic parameters for enzyme conformational changes and chemistry (rate constants and activation enthalpy). Comparisons between wild-type enzyme and a mutant resistant to nucleoside analogs used to treat HIV infections reveal that the ground state binding is weaker and the activation enthalpy for the conformational change step is significantly larger for the mutant. Further studies to explore the structural underpinnings of the observed thermodynamics and kinetics of the conformational change step may help to design better analogs to treat HIV infections and other diseases. Our new method is generally applicable to enzyme and chemical kinetics.

  2. An empirical assessment of fixed and random parameter logit models using crash- and non-crash-specific injury data.

    Science.gov (United States)

    Ch Anastasopoulos, Panagiotis; Mannering, Fred L

    2011-05-01

    Traditional crash-severity modeling uses detailed data gathered after a crash has occurred (number of vehicles involved, age of occupants, weather conditions at the time of the crash, types of vehicles involved, crash type, occupant restraint use, airbag deployment, etc.) to predict the level of occupant injury. However, for prediction purposes, the use of such detailed data makes assessing the impact of alternate safety countermeasures exceedingly difficult due to the large number of variables that need to be known. Using 5-year data from interstate highways in Indiana, this study explores fixed and random parameter statistical models using detailed crash-specific data and data that include the injury outcome of the crash but not other detailed crash-specific data (only more general data are used such as roadway geometrics, pavement condition and general weather and traffic characteristics). The analysis shows that, while models that do not use detailed crash-specific data do not perform as well as those that do, random parameter models using less detailed data still can provide a reasonable level of accuracy.

  3. Assessing Optimal Flight Parameters for Generating Accurate Multispectral Orthomosaicks by UAV to Support Site-Specific Crop Management

    Directory of Open Access Journals (Sweden)

    Francisco-Javier Mesas-Carrascosa

    2015-09-01

    Full Text Available This article describes the technical specifications and configuration of a multirotor unmanned aerial vehicle (UAV to acquire remote images using a six-band multispectral sensor. Several flight missions were programmed as follows: three flight altitudes (60, 80 and 100 m, two flight modes (stop and cruising modes and two ground control point (GCP settings were considered to analyze the influence of these parameters on the spatial resolution and spectral discrimination of multispectral orthomosaicked images obtained using Pix4Dmapper. Moreover, it is also necessary to consider the area to be covered or the flight duration according to any flight mission programmed. The effect of the combination of all these parameters on the spatial resolution and spectral discrimination of the orthomosaicks is presented. Spectral discrimination has been evaluated for a specific agronomical purpose: to use the UAV remote images for the detection of bare soil and vegetation (crop and weeds for in-season site-specific weed management. These results show that a balance between spatial resolution and spectral discrimination is needed to optimize the mission planning and image processing to achieve   every agronomic objective. In this way, users do not have to sacrifice flying at low altitudes to cover the whole area of interest completely.

  4. Nuclide documentation. Element specific parameter values used in the biospheric models of the safety assessments SR 97 and SAFE

    Energy Technology Data Exchange (ETDEWEB)

    Karlsson, Sara; Bergstroem, Ulla [Studsvik Eco and Safety AB, Nykoeping (Sweden)

    2002-05-01

    In this report the element and nuclide specific parameter values used in the biospheric models of the safety assessments SR 97 and SAFE are presented. The references used are presented and where necessary the process of estimation of data is described. The parameters treated in this report are distribution coefficients in soil, organic soil and suspended matter in freshwater and brackish water, root uptake factors for pasturage, cereals, root crops and vegetables, bioaccumulation factors for freshwater fish, brackish water fish, freshwater invertebrates and marine water plants, transfer coefficients for transfer to milk and meat, translocation factors and dose coefficients for external exposure, ingestion (age-dependent values) and inhalation (age-dependent values). The radionuclides treated are those which could be of interest in the two safety assessments. Physical data such as half-lives and type of decay are also presented.

  5. Computer modeling and laboratory experiments of a specific borehole to surface electrical monitoring technique (BSEMT)

    NARCIS (Netherlands)

    Meekes, J.A.C.; Zhang, X.; Abdul Fattah, R.

    2011-01-01

    Geophysical monitoring of the dynamical behavior of subsurface reservoirs (oil, gas, CO2) remains an important issue in geophysical research. A new idea for reservoir monitoring based on electrical resistivity tomography was developed at TNO. The essential element of the so-called BSEMT (Borehole to

  6. A Forward Incremental Prestressing Method with Application to Inverse Parameter Estimations and Eye-Specific Simulations of Posterior Scleral Shells

    Science.gov (United States)

    Downs, J. Crawford

    2012-01-01

    Numerical simulations or inverse numerical analyses of individual eyes or eye segments are often based on an eye-specific geometry obtained from in vivo medical images such as CT scans or from in vitro 3D digitizer scans. These eye-specific geometries are usually measured while the eye is subjected to internal pressure. Due to the nonlinear stiffening of the collagen fibril network in the eye, numerical incorporation of the pre-existing stress/strain state may be essential for realistic eye-specific computational simulations. Existing prestressing methods either compute accurate predictions of the prestressed state or guarantee a unique solution. In this contribution, a forward incremental pre-stressing method is presented that unifies the advantages of the existing approaches by providing accurate and unique predictions of the pre-existing stress/strain state at the true measured geometry. The impact of prestressing is investigated on (i) the inverse constitutive parameter identification of a synthetic sclera inflation test and (ii) an eye-specific simulation that estimates the realistic mechanical response of a preloaded posterior monkey scleral shell. Evaluation of the pre-existing stress/strain state in the inverse analysis had a significant impact on the reproducibility of the constitutive parameters but may be estimated based on an approximative approach. The eye-specific simulation of one monkey eye shows that prestressing is required for accurate displacement and stress/strain predictions. The numerical results revealed an increasing error in displacement, strain and stress predictions with increasing pre-existing pressure load when the pre-stress/strain state is disregarded. Disregarding the prestress may lead to a significant underestimation of the strain/stress environment in the sclera and overestimation in the lamina cribrosa. PMID:22224843

  7. Vehicle monitoring under Vehicular Ad-Hoc Networks (VANET) parameters employing illumination invariant correlation filters for the Pakistan motorway police

    Science.gov (United States)

    Gardezi, A.; Umer, T.; Butt, F.; Young, R. C. D.; Chatwin, C. R.

    2016-04-01

    A spatial domain optimal trade-off Maximum Average Correlation Height (SPOT-MACH) filter has been previously developed and shown to have advantages over frequency domain implementations in that it can be made locally adaptive to spatial variations in the input image background clutter and normalised for local intensity changes. The main concern for using the SPOT-MACH is its computationally intensive nature. However in the past enhancements techniques were proposed for the SPOT-MACH to make its execution time comparable to its frequency domain counterpart. In this paper a novel approach is discussed which uses VANET parameters coupled with the SPOT-MACH in order to minimise the extensive processing of the large video dataset acquired from the Pakistan motorways surveillance system. The use of VANET parameters gives us an estimation criterion of the flow of traffic on the Pakistan motorway network and acts as a precursor to the training algorithm. The use of VANET in this scenario would contribute heavily towards the computational complexity minimization of the proposed monitoring system.

  8. Online Structural Health Monitoring and Parameter Estimation for Vibrating Active Cantilever Beams Using Low-Priced Microcontrollers

    Directory of Open Access Journals (Sweden)

    Gergely Takács

    2015-01-01

    Full Text Available This paper presents a structural health monitoring and parameter estimation system for vibrating active cantilever beams using low-cost embedded computing hardware. The actuator input and the measured position are used in an augmented nonlinear model to observe the dynamic states and parameters of the beam by the continuous-discrete extended Kalman filter (EKF. The presence of undesirable structural change is detected by variations of the first resonance estimate computed from the observed equivalent mass, stiffness, damping, and voltage-force conversion coefficients. A fault signal is generated upon its departure from a predetermined nominal tolerance band. The algorithm is implemented using automatically generated and deployed machine code on an electronics prototyping platform, featuring an economically feasible 8-bit microcontroller unit (MCU. The validation experiments demonstrate the viability of the proposed system to detect sudden or gradual mechanical changes in real-time, while the functionality on low-cost miniaturized hardware suggests a strong potential for mass-production and structural integration. The modest computing power of the microcontroller and automated code generation designates the proposed system only for very flexible structures, with a first dominant resonant frequency under 4 Hz; however, a code-optimized version certainly allows much stiffer structures or more complicated models on the same hardware.

  9. Domain-Specific Antecedents of Parental Psychological Control and Monitoring: The Role of Parenting Beliefs and Practices.

    Science.gov (United States)

    Smetana, Judith G.; Daddis, Christopher

    2002-01-01

    Examined effects of domain-differentiated beliefs about legitimate parental authority, and ratings of restrictive parental control and adolescent- and mother- reported psychological and behavioral control. Found that domain-specific parenting beliefs and ratings predicted adolescent-reported maternal psychological control and parental monitoring.…

  10. 40 CFR 75.18 - Specific provisions for monitoring emissions from common and by-pass stacks for opacity.

    Science.gov (United States)

    2010-07-01

    ... emissions from common and by-pass stacks for opacity. 75.18 Section 75.18 Protection of Environment... Provisions § 75.18 Specific provisions for monitoring emissions from common and by-pass stacks for opacity. (a) Unit using common stack.When an affected unit utilizes a common stack with other affected...

  11. Hardware Specific Integration Strategy for Impedance-Based Structural Health Monitoring of Aerospace Systems

    Science.gov (United States)

    Owen, Robert B.; Gyekenyesi, Andrew L.; Inman, Daniel J.; Ha, Dong S.

    2011-01-01

    The Integrated Vehicle Health Management (IVHM) Project, sponsored by NASA's Aeronautics Research Mission Directorate, is conducting research to advance the state of highly integrated and complex flight-critical health management technologies and systems. An effective IVHM system requires Structural Health Monitoring (SHM). The impedance method is one such SHM technique for detection and monitoring complex structures for damage. This position paper on the impedance method presents the current state of the art, future directions, applications and possible flight test demonstrations.

  12. Quality changes of pasteurised orange juice during storage: A kinetic study of specific parameters and their relation to colour instability.

    Science.gov (United States)

    Wibowo, Scheling; Grauwet, Tara; Santiago, Jihan Santanina; Tomic, Jovana; Vervoort, Liesbeth; Hendrickx, Marc; Van Loey, Ann

    2015-11-15

    In view of understanding colour instability of pasteurised orange juice during storage, to the best of our knowledge, this study reports for the first time in a systematic and quantitative way on a range of changes in specific quality parameters as a function of time and as well as temperature (20-42 °C). A zero-order (°Brix, fructose, glucose), a first-order (vitamin C), a second-order (sucrose) and a fractional conversion model (oxygen) were selected to model the evolution of the parameters between parentheses. Activation energies ranged from 22 to 136 kJ mol(-1), HMF formation being the most temperature sensitive. High correlations were found between sugars, ascorbic acid, their degradation products (furfural and HMF) and total colour difference (ΔE(∗)). Based on PLS regression, the importance of the quality parameters for colour degradation was ranked relatively among each other: the acid-catalysed degradation of sugars and ascorbic acid degradation reactions appeared to be important for browning development in pasteurised orange juice during ambient storage.

  13. Diamond Tool Specific Wear Rate Assessment in Granite Machining by Means of Knoop Micro-Hardness and Process Parameters

    Science.gov (United States)

    Goktan, R. M.; Gunes Yılmaz, N.

    2017-09-01

    The present study was undertaken to investigate the potential usability of Knoop micro-hardness, both as a single parameter and in combination with operational parameters, for sawblade specific wear rate (SWR) assessment in the machining of ornamental granites. The sawing tests were performed on different commercially available granite varieties by using a fully instrumented side-cutting machine. During the sawing tests, two fundamental productivity parameters, namely the workpiece feed rate and cutting depth, were varied at different levels. The good correspondence observed between the measured Knoop hardness and SWR values for different operational conditions indicates that it has the potential to be used as a rock material property that can be employed in preliminary wear estimations of diamond sawblades. Also, a multiple regression model directed to SWR prediction was developed which takes into account the Knoop hardness, cutting depth and workpiece feed rate. The relative contribution of each independent variable in the prediction of SWR was determined by using test statistics. The prediction accuracy of the established model was checked against new observations. The strong prediction performance of the model suggests that its framework may be applied to other granites and operational conditions for quantifying or differentiating the relative wear performance of diamond sawblades.

  14. Effect of operating parameters on indium (III) ion removal by iron electrocoagulation and evaluation of specific energy consumption.

    Science.gov (United States)

    Chou, Wei-Lung; Wang, Chih-Ta; Huang, Kai-Yu

    2009-08-15

    The aim of this study is to investigate the effects of operating parameters on the specific energy consumption and removal efficiency of synthetic wastewater containing indium (III) ions by electrocoagulation in batch mode using an iron electrode. Several parameters, including different electrode pairs, supporting electrolytes, initial concentration, pH variation, and applied voltage, were investigated. In addition, the effects of applied voltage, supporting electrolyte, and initial concentration on indium (III) ion removal efficiency and specific energy consumption were investigated under the optimum balance of reasonable removal efficiency and relative low energy consumption. Experiment results indicate that a Fe/Al electrode pair is the most efficient choice of the four electrode pairs in terms of energy consumption. The optimum supporting electrolyte concentration, initial concentration, and applied voltage were found to be 100 mg/l NaCl, 20 mg/l, and 20V, respectively. A higher pH at higher applied voltage (20 or 30V) enhanced the precipitation of indium (III) ion as insoluble indium hydroxide, which improved the removal efficiency. Results from the indium (III) ion removal kinetics show that the kinetics data fit the pseudo second-order kinetic model well. Finally, the composition of the sludge produced was characterized with energy dispersion spectra (EDS).

  15. Effect of operating parameters on indium (III) ion removal by iron electrocoagulation and evaluation of specific energy consumption

    Energy Technology Data Exchange (ETDEWEB)

    Chou, Wei-Lung, E-mail: wlchou0388@hotmail.com [Department of Safety, Health and Environmental Engineering, Hungkuang University, Sha-Lu, Taichung 433, Taiwan (China); Wang, Chih-Ta [Department of Safety Health and Environmental Engineering, Chung Hwa University of Medical Technology, Tainan Hsien 717, Taiwan (China); Huang, Kai-Yu [Department of Safety, Health and Environmental Engineering, Hungkuang University, Sha-Lu, Taichung 433, Taiwan (China)

    2009-08-15

    The aim of this study is to investigate the effects of operating parameters on the specific energy consumption and removal efficiency of synthetic wastewater containing indium (III) ions by electrocoagulation in batch mode using an iron electrode. Several parameters, including different electrode pairs, supporting electrolytes, initial concentration, pH variation, and applied voltage, were investigated. In addition, the effects of applied voltage, supporting electrolyte, and initial concentration on indium (III) ion removal efficiency and specific energy consumption were investigated under the optimum balance of reasonable removal efficiency and relative low energy consumption. Experiment results indicate that a Fe/Al electrode pair is the most efficient choice of the four electrode pairs in terms of energy consumption. The optimum supporting electrolyte concentration, initial concentration, and applied voltage were found to be 100 mg/l NaCl, 20 mg/l, and 20 V, respectively. A higher pH at higher applied voltage (20 or 30 V) enhanced the precipitation of indium (III) ion as insoluble indium hydroxide, which improved the removal efficiency. Results from the indium (III) ion removal kinetics show that the kinetics data fit the pseudo second-order kinetic model well. Finally, the composition of the sludge produced was characterized with energy dispersion spectra (EDS).

  16. The GTN-P Data Management System: A central database for permafrost monitoring parameters of the Global Terrestrial Network for Permafrost (GTN-P) and beyond

    Science.gov (United States)

    Lanckman, Jean-Pierre; Elger, Kirsten; Karlsson, Ævar Karl; Johannsson, Halldór; Lantuit, Hugues

    2013-04-01

    Permafrost is a direct indicator of climate change and has been identified as Essential Climate Variable (ECV) by the global observing community. The monitoring of permafrost temperatures, active-layer thicknesses and other parameters has been performed for several decades already, but it was brought together within the Global Terrestrial Network for Permafrost (GTN-P) in the 1990's only, including the development of measurement protocols to provide standardized data. GTN-P is the primary international observing network for permafrost sponsored by the Global Climate Observing System (GCOS) and the Global Terrestrial Observing System (GTOS), and managed by the International Permafrost Association (IPA). All GTN-P data was outfitted with an "open data policy" with free data access via the World Wide Web. The existing data, however, is far from being homogeneous: it is not yet optimized for databases, there is no framework for data reporting or archival and data documentation is incomplete. As a result, and despite the utmost relevance of permafrost in the Earth's climate system, the data has not been used by as many researchers as intended by the initiators of the programs. While the monitoring of many other ECVs has been tackled by organized international networks (e.g. FLUXNET), there is still no central database for all permafrost-related parameters. The European Union project PAGE21 created opportunities to develop this central database for permafrost monitoring parameters of GTN-P during the duration of the project and beyond. The database aims to be the one location where the researcher can find data, metadata, and information of all relevant parameters for a specific site. Each component of the Data Management System (DMS), including parameters, data levels and metadata formats were developed in cooperation with the GTN-P and the IPA. The general framework of the GTN-P DMS is based on an object oriented model (OOM), open for as many parameters as possible, and

  17. Neural Network Classifier for Automatic Detection of Invasive Versus Noninvasive Airway Management Technique Based on Respiratory Monitoring Parameters in a Pediatric Anesthesia.

    Science.gov (United States)

    Gálvez, Jorge A; Jalali, Ali; Ahumada, Luis; Simpao, Allan F; Rehman, Mohamed A

    2017-08-23

    Children undergoing general anesthesia require airway monitoring by an anesthesia provider. The airway may be supported with noninvasive devices such as face mask or invasive devices such as a laryngeal mask airway or an endotracheal tube. The physiologic data stored provides an opportunity to apply machine learning algorithms distinguish between these modes based on pattern recognition. We retrieved three data sets from patients receiving general anesthesia in 2015 with either mask, laryngeal mask airway or endotracheal tube. Patients underwent myringotomy, tonsillectomy, adenoidectomy or inguinal hernia repair procedures. We retrieved measurements for end-tidal carbon dioxide, tidal volume, and peak inspiratory pressure and calculated statistical features for each data element per patient. We applied machine learning algorithms (decision tree, support vector machine, and neural network) to classify patients into noninvasive or invasive airway device support. We identified 300 patients per group (mask, laryngeal mask airway, and endotracheal tube) for a total of 900 patients. The neural network classifier performed better than the boosted trees and support vector machine classifiers based on the test data sets. The sensitivity, specificity, and accuracy for neural network classification are 97.5%, 96.3%, and 95.8%. In contrast, the sensitivity, specificity, and accuracy of support vector machine are 89.1%, 92.3%, and 88.3% and with the boosted tree classifier they are 93.8%, 92.1%, and 91.4%. We describe a method to automatically distinguish between noninvasive and invasive airway device support in a pediatric surgical setting based on respiratory monitoring parameters. The results show that the neural network classifier algorithm can accurately classify noninvasive and invasive airway device support.

  18. Two distinct auditory-motor circuits for monitoring speech production as revealed by content-specific suppression of auditory cortex.

    Science.gov (United States)

    Ylinen, Sari; Nora, Anni; Leminen, Alina; Hakala, Tero; Huotilainen, Minna; Shtyrov, Yury; Mäkelä, Jyrki P; Service, Elisabet

    2015-06-01

    Speech production, both overt and covert, down-regulates the activation of auditory cortex. This is thought to be due to forward prediction of the sensory consequences of speech, contributing to a feedback control mechanism for speech production. Critically, however, these regulatory effects should be specific to speech content to enable accurate speech monitoring. To determine the extent to which such forward prediction is content-specific, we recorded the brain's neuromagnetic responses to heard multisyllabic pseudowords during covert rehearsal in working memory, contrasted with a control task. The cortical auditory processing of target syllables was significantly suppressed during rehearsal compared with control, but only when they matched the rehearsed items. This critical specificity to speech content enables accurate speech monitoring by forward prediction, as proposed by current models of speech production. The one-to-one phonological motor-to-auditory mappings also appear to serve the maintenance of information in phonological working memory. Further findings of right-hemispheric suppression in the case of whole-item matches and left-hemispheric enhancement for last-syllable mismatches suggest that speech production is monitored by 2 auditory-motor circuits operating on different timescales: Finer grain in the left versus coarser grain in the right hemisphere. Taken together, our findings provide hemisphere-specific evidence of the interface between inner and heard speech.

  19. Monitoring scale-specific and temporal variation in electromagnetic conductivity images

    Science.gov (United States)

    In the semi-arid and arid landscapes of southwest USA, irrigation sustains agricultural activity; however, there are increasing demands on water resources. As such spatial temporal variation of soil moisture needs to be monitored. One way to do this is to use electromagnetic (EM) induction instrumen...

  20. Celiac Disease in Adult Patients: Specific Autoantibodies in the Diagnosis, Monitoring, and Screening

    Directory of Open Access Journals (Sweden)

    Evagelia Trigoni

    2014-01-01

    Full Text Available The increasing prevalence of celiac disease (CD, especially in adults, its atypical clinical presentation, and the strict, lifelong adherence to gluten-free diet (GFD as the only option for healthy state create an imperative need for noninvasive methods that can effectively diagnose CD and monitor GFD. Aim. Evaluation of anti-endomysium (EmA and anti-tissue transglutaminase IgA (tTG-A antibodies in CD diagnosis, GFD monitoring, and first degree relatives screening in CD adult patients. Methods. 70 newly diagnosed Greek adult patients, 70 controls, and 47 first degree relatives were tested for the presence of EmA and tTG-A. The CD patients were monitored during a 3-year period. Results. EmA predictive ability for CD diagnosis was slightly better compared to tTG-A (P=0.043. EmA could assess compliance with GFD already from the beginning of the diet, while both EmA and tTG-A had an equal ability to discriminate between strictly and partially compliant patients after the first semester and so on. Screening of first degree relatives resulted in the identification of 2 undiagnosed CD cases. Conclusions. Both EmA and tTG-A are suitable markers in the CD diagnosis, in the screening of CD among first degree relatives, having also an equal performance in the long term monitoring.

  1. Celiac disease in adult patients: specific autoantibodies in the diagnosis, monitoring, and screening.

    Science.gov (United States)

    Trigoni, Evagelia; Tsirogianni, Alexandra; Pipi, Elena; Mantzaris, Gerassimos; Papasteriades, Chryssa

    2014-01-01

    The increasing prevalence of celiac disease (CD), especially in adults, its atypical clinical presentation, and the strict, lifelong adherence to gluten-free diet (GFD) as the only option for healthy state create an imperative need for noninvasive methods that can effectively diagnose CD and monitor GFD. Aim. Evaluation of anti-endomysium (EmA) and anti-tissue transglutaminase IgA (tTG-A) antibodies in CD diagnosis, GFD monitoring, and first degree relatives screening in CD adult patients. Methods. 70 newly diagnosed Greek adult patients, 70 controls, and 47 first degree relatives were tested for the presence of EmA and tTG-A. The CD patients were monitored during a 3-year period. Results. EmA predictive ability for CD diagnosis was slightly better compared to tTG-A (P = 0.043). EmA could assess compliance with GFD already from the beginning of the diet, while both EmA and tTG-A had an equal ability to discriminate between strictly and partially compliant patients after the first semester and so on. Screening of first degree relatives resulted in the identification of 2 undiagnosed CD cases. Conclusions. Both EmA and tTG-A are suitable markers in the CD diagnosis, in the screening of CD among first degree relatives, having also an equal performance in the long term monitoring.

  2. Specifications and design criteria for innovative corrosion monitoring and (downhole) sensor systems, including sensitivity analysis

    NARCIS (Netherlands)

    Zhang, X.; Kermen. E.

    2013-01-01

    This report focuses on the corrosion monitoring and corrosion sensor systems, for use in CO2 storage wells, including a sensitivity analysis. The feasibility for using new sensors to measure well integrity based on electrochemical principles is investigated. The use of corrosion sensors in CO2 stora

  3. Influence of Confocal Scanning Laser Microscopy specific acquisition parameters on the detection and matching of Speeded-Up Robust Features

    Energy Technology Data Exchange (ETDEWEB)

    Stanciu, Stefan G., E-mail: sgstanciu@gmail.com [Center for Microscopy-Microanalysis and Information Processing, University Politehnica Bucharest, Splaiul Independentei 313, sector 6, Bucharest (Romania); Hristu, Radu; Stanciu, George A. [Center for Microscopy-Microanalysis and Information Processing, University Politehnica Bucharest, Splaiul Independentei 313, sector 6, Bucharest (Romania)

    2011-04-15

    The robustness and distinctiveness of local features to various object or scene deformations and to modifications of the acquisition parameters play key roles in the design of many computer vision applications. In this paper we present the results of our experiments on the behavior of a recently developed technique for local feature detection and description, Speeded-Up Robust Features (SURF), regarding image modifications specific to Confocal Scanning Laser Microscopy (CSLM). We analyze the repeatability of detected SURF keypoints and the precision-recall of their matching under modifications of three important CSLM parameters: pinhole aperture, photomultiplier (PMT) gain and laser beam power. During any investigation by CSLM these three parameters have to be modified, individually or together, in order to optimize the contrast and the Signal Noise Ratio (SNR), being also inherently modified when changing the microscope objective. Our experiments show that an important amount of SURF features can be detected at the same physical locations in images collected at different values of the pinhole aperture, PMT gain and laser beam power, and further on can be successfully matched based on their descriptors. In the final part, we exemplify the potential of SURF in CSLM imaging by presenting a SURF-based computer vision application that deals with the mosaicing of images collected by this technique. -- Research highlights: {yields} Influence of pinhole aperture modifications on SURF detection and matching in CSLM images. {yields} Influence of photomultiplier gain modifications on SURF detection and matching in CSLM images. {yields} Influence of laser beam power modifications on SURF detection and matching in CSLM images. {yields} SURF-based automated mosaicing of CSLM images.

  4. Enhanced Specificity and Efficiency of the CRISPR/Cas9 System with Optimized sgRNA Parameters in Drosophila

    Directory of Open Access Journals (Sweden)

    Xingjie Ren

    2014-11-01

    Full Text Available The CRISPR/Cas9 system has recently emerged as a powerful tool for functional genomic studies in Drosophila melanogaster. However, single-guide RNA (sgRNA parameters affecting the specificity and efficiency of the system in flies are still not clear. Here, we found that off-target effects did not occur in regions of genomic DNA with three or more nucleotide mismatches to sgRNAs. Importantly, we document for a strong positive correlation between mutagenesis efficiency and sgRNA GC content of the six protospacer-adjacent motif-proximal nucleotides (PAMPNs. Furthermore, by injecting well-designed sgRNA plasmids at the optimal concentration we determined, we could efficiently generate mutations in four genes in one step. Finally, we generated null alleles of HP1a using optimized parameters through homology-directed repair and achieved an overall mutagenesis rate significantly higher than previously reported. Our work demonstrates a comprehensive optimization of sgRNA and promises to vastly simplify CRISPR/Cas9 experiments in Drosophila.

  5. Adaptive long-term monitoring of soil health in metal phytostabilization: ecological attributes and ecosystem services based on soil microbial parameters.

    Science.gov (United States)

    Epelde, Lur; Becerril, José M; Alkorta, Itziar; Garbisu, Carlos

    2014-01-01

    Phytostabilization is a promising option for the remediation of metal contaminated soils which requires the implementation of long-term monitoring programs. We here propose to incorporate the paradigm of "adaptive monitoring", which enables monitoring programs to evolve iteratively as new information emerges and research questions change, to metal phytostabilization. Posing good questions that cover the chemical, toxicological and ecological concerns associated to metal contaminated soils is critical for an efficient long-term phytostabilization monitoring program. Regarding the ecological concerns, soil microbial parameters are most valuable indicators of the effectiveness of metal phytostabilization processes in terms of recovery of soil health. We suggest to group soil microbial parameters in higher-level categories such as "ecological attributes" (vigor, organization, stability) or "ecosystem services" in order to facilitate interpretation and, most importantly, to provide long-term phytostabilization monitoring programs with the required stability through time against changes in techniques, methods, interests, etc. that will inevitably occur during the monitoring program. Finally, a Phytostabilization Monitoring Card, based on both ecological attributes and ecosystem services, for soil microbial properties is provided.

  6. Domain-specific antecedents of parental psychological control and monitoring: the role of parenting beliefs and practices.

    Science.gov (United States)

    Smetana, Judith G; Daddis, Christopher

    2002-01-01

    This research examined the effects of domain-differentiated beliefs about legitimate parental authority and ratings of restrictive parental control on adolescent- and mother-reported psychological and behavioral control. The influence of parenting beliefs and practices regarding socially regulated (moral and conventional) and ambiguously personal (multifaceted and personal) issues was examined in 93 middle-class African American early adolescents (M = 13.11 years, SD = 1.29) and their mothers, who were followed longitudinally for 2 years. Domain-specific parenting beliefs and ratings predicted adolescent-reported maternal psychological control and parental monitoring, but the nature and direction of the relations differed. Adolescents who rated parents as more restrictive in their control of personal issues and who believed that parents should have less legitimate authority over these issues rated their mothers as higher in psychological control. In contrast, more adolescent-reported parental monitoring was associated with gender (being female) and adolescents' beliefs that parents have more legitimate authority to regulate personal issues. As expected, adolescent age and gender influenced mother-reported monitoring and psychological control; in addition, the effects of mothers' ratings of restrictive control on both psychological control and monitoring were moderated by gender. The results indicate that psychological control and monitoring can be understood in terms of the particular behaviors that are controlled, as well as the style in which control is exercised.

  7. Species-Specific Standard Redox Potential of Thiol-Disulfide Systems: A Key Parameter to Develop Agents against Oxidative Stress

    Science.gov (United States)

    Mirzahosseini, Arash; Noszál, Béla

    2016-11-01

    Microscopic standard redox potential, a new physico-chemical parameter was introduced and determined to quantify thiol-disulfide equilibria of biological significance. The highly composite, codependent acid-base and redox equilibria of thiols could so far be converted into pH-dependent, apparent redox potentials (E’°) only. Since the formation of stable metal-thiolate complexes precludes the direct thiol-disulfide redox potential measurements by usual electrochemical techniques, an indirect method had to be elaborated. In this work, the species-specific, pH-independent standard redox potentials of glutathione were determined primarily by comparing it to 1-methylnicotinamide, the simplest NAD+ analogue. Secondarily, the species-specific standard redox potentials of the two-electron redox transitions of cysteamine, cysteine, homocysteine, penicillamine, and ovothiol were determined using their microscopic redox equilibrium constants with glutathione. The 30 different, microscopic standard redox potential values show close correlation with the respective thiolate basicities and provide sound means for the development of potent agents against oxidative stress.

  8. [Dextrals and sinistrals (right-handers and left-handers): specificity of interhemispheric brain asymmetry and EEG coherence parameters].

    Science.gov (United States)

    Zhavoronkova, L A

    2007-01-01

    Data of literature about morphological, functional and biochemical specificity of the brain interhemispheric asymmetry of healthy right-handers and left-handers and about peculiarity of dynamics of cerebral pathology in patients with different individual asymmetry profiles are presented at the present article. Results of our investigation by using coherence parameters of electroencephalogram (EEG) in healthy right-handers and left-handers in state of rest, during functional tests and sleeping and in patients with different forms of the brain organic damage were analyzed too. EEG coherence analysis revealed the reciprocal changing of alpha-beta and theta-delta spectral bands in right-handers whilein left-handers synchronous changing of all EEG spectral bands were observed. Data about regional-frequent specificity of EEG coherence, peculiarity of EEG asymmetry in right-handers and left-handers, aslo about specificity of EEG spectral band genesis and point of view about a role of the brain regulator systems in forming of interhemispheric asymmetry in different functional states allowed to propose the conception about principle of interhermispheric brain asymmetry formation in left-handers and left-handers. Following this conception in dextrals elements of concurrent (summary-reciprocal) cooperation are predominant at the character of interhemispheric and cortical-subcortical interaction while in sinistrals a principle of concordance (supplementary) is preferable. These peculiarities the brain organization determine, from the first side, the quicker revovery of functions damaged after cranio-cerebral trauma in left-handers in comparison right-handers and from the other side - they determine the forming of the more expressed pathology in the remote terms after exposure the low dose of radiation.

  9. Intracranial Pressure Monitoring as a Part of Multimodal Monitoring Management of Patients with Critical Polytrauma: Correlation between Optimised Intensive Therapy According to Intracranial Pressure Parameters and Clinical Picture

    Science.gov (United States)

    Luca, Loredana; Rogobete, Alexandru Florin; Bedreag, Ovidiu Horea; Sarandan, Mirela; Cradigati, Carmen Alina; Papurica, Marius; Gruneantu, Anelore; Patrut, Raluca; Vernic, Corina; Dumbuleu, Corina Maria; Sandesc, Dorel

    2015-01-01

    Objective Trauma patient requires a complex therapeutic management because of multiple severe injuries or secondary complications. The most significant injury found in patients with trauma is head injury, which has the greatest impact on mortality. Intracranial pressure (ICP) monitoring is required in severe traumatic head injury because it optimises treatment based on ICP values and cerebral perfusion pressure (CPP). Methods From a total of 64 patients admitted in the intensive care unit (ICU) ‘Casa Austria’, from the Polytraumatology Clinic of the Emergency County Hospital “Pius Brinzeu” Timisoara, Romania, between January 2014 and December 2014; only patients who underwent ICP monitoring (n=10) were analysed. The study population was divided into several categories depending on the time passed since trauma to the time of installation of ICP monitoring (24 h). Comparisons were made in terms of the number of days admitted in the ICU and mortality between patients with head injury who benefited and those who did not benefit from ICP monitoring. Results The results show the positive influence of ICP monitoring on the number of admission days in ICU because of the possibility that the number of admission days to augment therapeutic effects in patients who benefited from ICP monitoring reduces by 1.93 days compared with those who did not undergo ICP monitoring. Conclusion ICP monitoring and optimizing therapy according to the ICP and CPP has significant influence on the rate of survival. ICP monitoring is necessary in all patients with head trauma injury according to recent guidelines. The main therapeutic goal in the management of the trauma patient with head injury is to minimize the destructive effects of the associated side effects. PMID:27366538

  10. Causes and Countermeasures of Alarm Parameters Setting Errors of ECG Monitor%监护仪报警参数设置错误的原因及对策

    Institute of Scientific and Technical Information of China (English)

    施娟娟; 王芳

    2014-01-01

    目的分析全院心电监护仪报警参数设置错误的原因,以制订有效对策。方法回顾性分析2013年1-6月份夜间质量检查中本院监护仪使用的报警参数设置错误项数及护士工龄分布,分析错误原因后,提出了相应的对策。结果心电监护仪报警参数设置错误213例中,其中心率报警参数设置错误占42.3%,工作1-2年和2-5年护士分别占27.2%和45.5%。结论制订统一的心电监护仪报警参数设置规范,对心电监护仪报警范围设置参考值,加强低年资护士岗前培训,以保证心电监护仪的监测质量和病人安全。%Objective Analyze the causes of error setting of ECG monitor alarm parameters to develop effective countermeasures. Methods Put forward countermeasures based on retrospective analysis on the number of alarm parameters setting errors of ECG monitor in quality inspection at night from January to June in 2013 in our hospital and the working years distribution of nurses. Result In the 213 cases of ECG monitor alarm parameter setting error, heart rate alarm parameter error accounted for 42.3% while 27.5% of the errors made by nurses with 1-2 years of working experiences and 45.5%by nurses with 2-5 years of working experiences. Conclusion Develop unified specifications on alarm parameter setting of ECG monitor, set up reference values for ECG monitor alarm range and enhance pre-job training for junior nurses to assure the monitor quality of ECG monitor and patients' safety.

  11. Quality by design approach of a pharmaceutical gel manufacturing process, part 2: near infrared monitoring of composition and physical parameters.

    Science.gov (United States)

    Rosas, Juan G; Blanco, Marcel; González, Josep M; Alcalá, Manel

    2011-10-01

    We applied the principles of quality by design to the production process of a pharmaceutical gel by using the near infrared spectroscopy (NIRS) technique in combination with multivariate chemometric tools. For this purpose, we constructed a D-optimal experimental design having normal operational condition (NOC) batches as central point. The primary aim here was to develop an expeditious NIRS method for determining the composition of a pharmaceutical gel and assess the temporal changes in major physical factors affecting the quality of the product (specifically, viscosity and pH). Gel components were quantified by using partial least squares (PLS) calibration models of the PLS1 type. The study was completed by using the batch statistical process control method to compare product batches included in the experimental design with NOC batches. Similarities and differences between the two types of batches were identified by using control charts for residuals (Q-statistic) and Hotteling's T2 (D-statistic). The ensuing models, which were subject to errors less than 5%, allowed the gel production process to be effectively monitored. As shown in this work, the NIRS technique is a highly suitable tool for process analytical technology.

  12. Transiting Exoplanet Monitoring Project (TEMP). II. Refined System Parameters and Transit Timing Analysis of HAT-P-33b

    Science.gov (United States)

    Wang, Yong-Hao; Wang, Songhu; Liu, Hui-Gen; Hinse, Tobias C.; Laughlin, Gregory; Wu, Dong-Hong; Zhang, Xiaojia; Zhou, Xu; Wu, Zhenyu; Zhou, Ji-Lin; Wittenmyer, R. A.; Eastman, Jason; Zhang, Hui; Hori, Yasunori; Narita, Norio; Chen, Yuanyuan; Ma, Jun; Peng, Xiyan; Zhang, Tian-Meng; Zou, Hu; Nie, Jun-Dan; Zhou, Zhi-Min

    2017-08-01

    We present 10 R-band photometric observations of eight different transits of the hot Jupiter HAT-P-33b, which has been targeted by our Transiting Exoplanet Monitoring Project. The data were obtained by two telescopes at the Xinglong Station of National Astronomical Observatories of China (NAOC) from 2013 December through 2016 January, and exhibit photometric scatter of 1.6{--}3.0 {mmag}. After jointly analyzing the previously published photometric data, radial-velocity (RV) measurements, and our new light curves, we revisit the system parameters and orbital ephemeris for the HAT-P-33b system. Our results are consistent with the published values except for the planet to star radius ratio ({R}{{P}}/{R}* ), the ingress/egress duration (τ) and the total duration (T 14), which together indicate a slightly shallower and shorter transit shape. Our results are based on more complete light curves, whereas the previously published work had only one complete transit light curve. No significant anomalies in Transit Timing Variations (TTVs) are found, and we place upper mass limits on potential perturbers, largely supplanting the loose constraints provided by the extant RV data. The TTV limits are stronger near mean-motion resonances, especially for the low-order commensurabilities. We can exclude the existence of a perturber with mass larger than 0.6, 0.3, 0.5, 0.5, and 0.3 {M}\\oplus near the 1:3, 1:2, 2:3, 3:2, and 2:1 resonances, respectively.

  13. CALCULATION METHOD OF PARAMETERS OF FOREST FIRES AS DYNAMIC PROCESSES ON THE EARTH’S SURFACE ON THE BASIS OF SPACE MONITORING DATA

    OpenAIRE

    Komorovsky, V.; Dorrer, G.

    2010-01-01

    A simple method for calculating the parameters of a forest fire is offered. The method is based on the representation of a fire as a mobile set on the surface of the Earth. The information base for the proposed methodology is the data of space monitoring of forest fires.

  14. Gender-specific impact of personal health parameters on individual brain aging in cognitively unimpaired elderly subjects

    Directory of Open Access Journals (Sweden)

    Katja eFranke

    2014-05-01

    Full Text Available Aging alters brain structure and function. Personal health markers and modifiable lifestyle factors are related to individual brain aging as well as to the risk of developing Alzheimer’s disease (AD. This study uses a novel magnetic resonance imaging (MRI-based biomarker to assess the effects of 17 health markers on individual brain aging in cognitively unimpaired elderly subjects. By employing kernel regression methods, the expression of normal brain-aging patterns forms the basis to estimate the brain age of a given new subject. If the estimated age is higher than the chronological age, a positive brain age gap estimation (BrainAGE score indicates accelerated atrophy and is considered a risk factor for developing AD. Within this cross-sectional, multi-center study 228 cognitively unimpaired elderly subjects (118 males completed an MRI at 1.5T, physiological and blood parameter assessments. The multivariate regression model combining all measured parameters was capable of explaining 39% of BrainAGE variance in males (p < 0.001 and 32% in females (p < 0.01. Furthermore, markers of the metabolic syndrome as well as markers of liver and kidney functions were profoundly related to BrainAGE scores in males (p < 0.05. In females, markers of liver and kidney functions as well as supply of vitamin B12 were significantly related to BrainAGE (p < 0.05. In conclusion, in cognitively unimpaired elderly subjects several clinical markers of poor health were associated with subtle structural changes in the brain that reflect accelerated aging, whereas protective effects on brain aging were observed for markers of good health. Additionally, the relations between individual brain aging and miscellaneous health markers show gender-specific patterns. The BrainAGE approach may thus serve as a clinically relevant biomarker for the detection of subtly abnormal patterns of brain aging probably preceding cognitive decline and development of AD.

  15. Detecting Specific Health-Related Events Using an Integrated Sensor System for Vital Sign Monitoring

    Directory of Open Access Journals (Sweden)

    Mourad Adnane

    2009-09-01

    Full Text Available In this paper, a new method for the detection of apnea/hypopnea periods in physiological data is presented. The method is based on the intelligent combination of an integrated sensor system for long-time cardiorespiratory signal monitoring and dedicated signal-processing packages. Integrated sensors are a PVDF film and conductive fabric sheets. The signal processing package includes dedicated respiratory cycle (RC and QRS complex detection algorithms and a new method using the respiratory cycle variability (RCV for detecting apnea/hypopnea periods in physiological data. Results show that our method is suitable for online analysis of long time series data.

  16. Seasonal and sex-specific variations in haematological parameters in 4 to 5.5-month-old infants in Guinea-Bissau, West Africa

    DEFF Research Database (Denmark)

    Bæk, Ole; Jensen, Kristoffer Jarlov; Andersen, Andreas

    2017-01-01

    Objective: This study investigated seasonal and sex-specific variations in the haematological parameters and established reference ranges for these parameters in healthy 4 to 5.5-month-old infants in Guinea-Bissau. Methods: Within a randomised trial of early measles vaccination, over a period of ...

  17. SYTO-13, a Viability Marker as a New Tool to Monitor In Vitro Pharmacodynamic Parameters of Anti-Pneumocystis Drugs.

    Directory of Open Access Journals (Sweden)

    Annie Standaert-Vitse

    Full Text Available While Pneumocystis pneumonia (PcP still impacts the AIDS patients, it has a growing importance in immunosuppressed HIV-negative patients. To determine the anti-Pneumocystis therapeutic efficacy of new compounds, animal and in vitro models have been developed. Indeed, well-designed mouse or rat experimental models of pneumocystosis can be used to describe the in vivo anti-Pneumocystis activity of new drugs. In vitro models, which enable the screening of a large panel of new molecules, have been developed using axenic cultures or co-culture with feeder cells; but no universally accepted standard method is currently available to evaluate anti-Pneumocystis molecules in vitro. Thus, we chose to explore the use of the SYTO-13 dye, as a new indicator of Pneumocystis viability. In the present work, we established the experimental conditions to define the in vitro pharmacodynamic parameters (EC50, Emax of marketed compounds (trimethoprim/sulfamethoxazole, pentamidine, atovaquone in order to specifically measure the intrinsic activity of these anti-P. carinii molecules using the SYTO-13 dye for the first time. Co-labelling the fungal organisms with anti-P. carinii specific antibodies enabled the measurement of viability of Pneumocystis organisms while excluding host debris from the analysis. Moreover, contrary to microscopic observation, large numbers of fungal cells can be analyzed by flow cytometry, thus increasing statistical significance and avoiding misreading during fastidious quantitation of stained organisms. In conclusion, the SYTO-13 dye allowed us to show a reproducible dose/effect relationship for the tested anti-Pneumocystis drugs.

  18. Implicit Treatment of Technical Specification and Thermal Hydraulic Parameter Uncertainties in Gaussian Process Model to Estimate Safety Margin

    Directory of Open Access Journals (Sweden)

    Douglas A. Fynan

    2016-06-01

    Full Text Available The Gaussian process model (GPM is a flexible surrogate model that can be used for nonparametric regression for multivariate problems. A unique feature of the GPM is that a prediction variance is automatically provided with the regression function. In this paper, we estimate the safety margin of a nuclear power plant by performing regression on the output of best-estimate simulations of a large-break loss-of-coolant accident with sampling of safety system configuration, sequence timing, technical specifications, and thermal hydraulic parameter uncertainties. The key aspect of our approach is that the GPM regression is only performed on the dominant input variables, the safety injection flow rate and the delay time for AC powered pumps to start representing sequence timing uncertainty, providing a predictive model for the peak clad temperature during a reflood phase. Other uncertainties are interpreted as contributors to the measurement noise of the code output and are implicitly treated in the GPM in the noise variance term, providing local uncertainty bounds for the peak clad temperature. We discuss the applicability of the foregoing method to reduce the use of conservative assumptions in best estimate plus uncertainty (BEPU and Level 1 probabilistic safety assessment (PSA success criteria definitions while dealing with a large number of uncertainties.

  19. Implicit treatment of technical specification and thermal hydraulic parameter uncertainties in Gaussian process model to estimate safety margin

    Energy Technology Data Exchange (ETDEWEB)

    Fynan, Douglas A.; Ahn, Kwang Il [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-06-15

    The Gaussian process model (GPM) is a flexible surrogate model that can be used for nonparametric regression for multivariate problems. A unique feature of the GPM is that a prediction variance is automatically provided with the regression function. In this paper, we estimate the safety margin of a nuclear power plant by performing regression on the output of best-estimate simulations of a large-break loss-of-coolant accident with sampling of safety system configuration, sequence timing, technical specifications, and thermal hydraulic parameter uncertainties. The key aspect of our approach is that the GPM regression is only performed on the dominant input variables, the safety injection flow rate and the delay time for AC powered pumps to start representing sequence timing uncertainty, providing a predictive model for the peak clad temperature during a reflood phase. Other uncertainties are interpreted as contributors to the measurement noise of the code output and are implicitly treated in the GPM in the noise variance term, providing local uncertainty bounds for the peak clad temperature. We discuss the applicability of the foregoing method to reduce the use of conservative assumptions in best estimate plus uncertainty (BEPU) and Level 1 probabilistic safety assessment (PSA) success criteria definitions while dealing with a large number of uncertainties.

  20. A Cysteine-Specific Fluorescent Switch for Monitoring Oxidative Stress and Quantification of Aminoacylase-1 in Blood Serum.

    Science.gov (United States)

    A, Anila H; Ali, Firoj; Kushwaha, Shilpi; Taye, Nandaraj; Chattopadhyay, Samit; Das, Amitava

    2016-12-20

    Reagents that allows detection and monitoring of crucial biomarkers with luminescence ON response have significance in clinical diagnostics. A new coumarin derivative is reported here, which could be used for specific and efficient chemodosimetric detection of cysteine, an important biomarker. The probe is successfully used for studying the biochemical transformation of N-acetylcysteine, a commonly prescribed Cys supplement drug to Cys by aminoacylase-1 (ACY-1), an important and endogenous mammalian enzyme. The possibility of using this reagent for quantification of ACY-1 in blood serum samples is also explored. Nontoxic nature and cell membrane permeability are key features of this probe and are ideally suited for imaging intracellular Cys in normal and cancerous cell lines. Our studies have also revealed that this reagent could be utilized as a redox switch to monitor the hydrogen-peroxide-induced oxidative stress in living SW480 cell lines. Peroxide-mediated cysteine oxidation has a special significance for understanding the cellular-signaling events.

  1. 40 CFR 63.3968 - What are the requirements for continuous parameter monitoring system installation, operation, and...

    Science.gov (United States)

    2010-07-01

    .... Monitoring failures that are caused in part by poor maintenance or careless operation are not malfunctions... install a device to monitor pressure drop across the zeolite wheel or rotary carbon bed. The pressure... signal simulations or via relative accuracy testing. (v) Conduct an accuracy audit every quarter and...

  2. 40 CFR 63.4168 - What are the requirements for continuous parameter monitoring system installation, operation, and...

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... monitor pressure drop across the zeolite wheel or rotary carbon bed. The pressure monitoring device must... pressure sensor(s) in or as close to a position that provides a representative measurement of the pressure...

  3. Use of Audible and Chart-recorded Ultrasonography to Monitor Fetal Heart Rate and Uterine Blood Flow Parameters in Cattle

    Science.gov (United States)

    The objective of the present study was to evaluate the use of audible chart-recorded doppler ultrasonography (DUS) to monitor both uterine blood flow and fetal heart rate (FHR) during pregnancy in dairy cattle. Possible applications of DUS include the monitoring of fetal distress when a pregnancy be...

  4. On-line acquisition of plant related and environmental parameters (plant monitoring) in gerbera: determining plant responses

    NARCIS (Netherlands)

    Baas, R.; Slootweg, G.

    2004-01-01

    For on-line plant monitoring equipment to be functional in commercial glasshouse horticulture, relations between sensor readings and plant responses on both the short (days) and long term (weeks) are required. For this reason, systems were installed to monitor rockwool grown gerbera plants on a

  5. SNM gamma-ray fingerprint monitor functional requirements and design specifications

    Energy Technology Data Exchange (ETDEWEB)

    Bieber, A.M. Jr.; Kane, W.R.

    1994-07-01

    A number of DOE facilities need to perform confirmatory inventory measurements on items of special nuclear material (SNM). The DOE Office of Safeguards and Security (OSS) has tasked the Safeguards, Safety and Nonproliferation Division (SSN) of the Department of Advanced Technology at Brookhaven National Laboratory (BNL) to develop a high-resolution gamma-ray-spectroscopy-based instrument for performing confirmatory inventory measurements on such materials, a ``gamma-ray fingerprint monitor`` (GRFM). This document is a conceptual design for the SSN GRFM system. This conceptual design is based on previous experience with measurements of plutonium-bearing materials and comparison of gamma-ray spectrum features, not on actual tests of the procedures or hardware described. As a result, modifications may be necessary when actual prototype hardware and software are tested in realistic circumstances on actual materials of interest.

  6. Technical specifications on randomised sampling for harmonised monitoring of antimicrobial resistance in zoonotic and commensal bacteria

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2014-05-01

    Full Text Available To monitor antimicrobial resistance in zoonotic and indicator bacteria from food-producing animal populations and meat thereof under Decision 2013/652/EC, a guidance for randomised sampling procedures is provided. Prospective and retrospective sampling plans for samples and isolates are addressed. The former involves collecting sufficient numbers of representative animal and food samples from which recovered isolates are tested for susceptibility; the latter involves selecting randomly Salmonella isolates from collections constituted within the framework of either the national control programmes in poultry flocks or from verification of the compliance with process hygiene criterion in broiler carcases. A generic proportionate stratified sampling process is proposed and numerical illustrations of proportional allocation are provided. Stratified sampling of Salmonella isolates from poultry primary productions is performed with proportional allocation to the size of the isolate collections available in the official laboratories. An alternative approach would be a simple random sampling within the sampling frame of flocks positive for Salmonella. Stratified sampling of caecal samples, accounting for at least 60 % of the domestic production of food-producing animal populations monitored, with proportionate allocation to the slaughterhouse production, allows for the collection of representative isolates of Campylobacter and indicator E. coli and enterococci in various animal populations. Stratified sampling of Salmonella isolates from broiler carcases is proposed with proportional allocation to the size of the isolate collections available in the official laboratories involved in verifying the compliance with the Salmonella process hygiene criterion. These isolates may be complemented with those recovered by the food business operator. Sampling of different chilled fresh meat categories is targeted at retail outlets serving the final consumer, with

  7. Near real-time monitoring and mapping of specific conductivity levels across Lake Texoma, USA

    Science.gov (United States)

    Atkinson, S.F.; Mabe, J.A.

    2006-01-01

    A submersible sonde equipped with a specific conductivity probe, linked with a global positioning satellite receiver was developed, deployed on a small boat, and used to map spatial and temporal variations in specific conductivity in a large reservoir. 7,695 sample points were recorded during 8 sampling trips. Specific conductivity ranged from 442 uS/cm to 3,378 uS/cm over the nine-month study. The data showed five statistically different zones in the reservoir: 2 different riverine zones, 2 different riverine transition zones, and a lacustrine zone (the main lake zone). These data were imported to a geographic information system where they were spatially interpolated to generate 8 maps showing specific conductivity levels across the entire surface of the lake. The highly dynamic nature of water quality, due to the widely differing nature of the rivers that flow into the reservoir and the effect of large inflows of fresh water during winter storms is easily captured and visualized using this approach. ?? Springer Science+Business Media, Inc. 2006.

  8. Surrogate parameters for rapid monitoring of contaminant removal for activated sludge treatment plants for para rubber and seafood industries in Southern Thailand

    Directory of Open Access Journals (Sweden)

    Panalee Chevakidagarn

    2005-03-01

    Full Text Available This study aimed at using surrogate parameters for rapid monitoring of contaminant removed of activated sludge treatment plant for para rubber and seafood industries in Southern Thailand. Wastewaters from these industries contain high organic concentrations and chemicals. The activated sludge process (AS is usually applied as a treatment process. However, plant operators generally lack the understanding and means to control the treatment plants because of a continuous monitoring system is not employed and the monitoring parameters are time consuming. UV absorbency at various wavelengths was used in this study as a surrogate parameters, for predicting the removal capacity of each plant. COD, BOD, suspended solids and nitrate-nitrogen concentrations could be estimated reliably without being time consuming. The results showed that UV absorbency at 220 nm can be used as a parameter to predict nitrate-nitrogen concentrations which less than 15 mg/L. That at 550 nm is for predicting suspended solids concentration and that at 260 nm is for COD predict.

  9. Feasibility study for the development of certified reference materials for specific migration testing. Part 2: Estimation of diffusion parameters and comparison of experimental and predicted data

    NARCIS (Netherlands)

    Stoffers, N.H.; Brandsch, R.; Bradley, E.L.; Cooper, I.; Dekker, M.; Störmer, A.; Franz, R.

    2005-01-01

    This paper describes the second part of a project whose main objective was to develop the know-how to produce certified reference materials (CRMs) for specific migration testing. Certification parameters discussed are the diffusion coefficient, DP, the respective polymer-specific coefficient, AP, of

  10. MONITORING OF IN-FIELD VARIABILITY FOR SITE SPECIFIC CROP MANAGEMENT THROUGH OPEN GEOSPATIAL INFORMATION

    Directory of Open Access Journals (Sweden)

    T. Řezník

    2016-06-01

    Full Text Available The agricultural sector is in a unique position due to its strategic importance around the world. It is crucial for both citizens (consumers and the economy (both regional and global, which, ideally, should ensure that the whole sector is a network of interacting organisations. It is important to develop new tools, management methods, and applications to improve the management and logistic operations of agricultural producers (farms and agricultural service providers. From a geospatial perspective, this involves identifying cost optimization pathways, reducing transport, reducing environmental loads, and improving the energy balance, while maintaining production levels, etc. This paper describes the benefits of, and open issues arising from, the development of the Open Farm Management Information System. Emphasis is placed on descriptions of available remote sensing and other geospatial data, and their harmonization, processing, and presentation to users. At the same time, the FOODIE platform also offers a novel approach of yield potential estimations. Validation for one farm demonstrated 70% successful rate when comparing yield results at a farm counting 1’284 hectares on one hand and results of a theoretical model of yield potential on the other hand. The presented Open Farm Management Information System has already been successfully registered under Phase 8 of the Global Earth Observation System of Systems (GEOSS Architecture Implementation Pilot in order to support the wide variety of demands that are primarily aimed at agriculture and water pollution monitoring by means of remote sensing.

  11. Monitoring of In-Field Variability for Site Specific Crop Management Through Open Geospatial Information

    Science.gov (United States)

    Řezník, T.; Lukas, V.; Charvát, K.; Charvát, K., Jr.; Horáková, Š.; Křivánek, Z.; Herman, L.

    2016-06-01

    The agricultural sector is in a unique position due to its strategic importance around the world. It is crucial for both citizens (consumers) and the economy (both regional and global), which, ideally, should ensure that the whole sector is a network of interacting organisations. It is important to develop new tools, management methods, and applications to improve the management and logistic operations of agricultural producers (farms) and agricultural service providers. From a geospatial perspective, this involves identifying cost optimization pathways, reducing transport, reducing environmental loads, and improving the energy balance, while maintaining production levels, etc. This paper describes the benefits of, and open issues arising from, the development of the Open Farm Management Information System. Emphasis is placed on descriptions of available remote sensing and other geospatial data, and their harmonization, processing, and presentation to users. At the same time, the FOODIE platform also offers a novel approach of yield potential estimations. Validation for one farm demonstrated 70% successful rate when comparing yield results at a farm counting 1'284 hectares on one hand and results of a theoretical model of yield potential on the other hand. The presented Open Farm Management Information System has already been successfully registered under Phase 8 of the Global Earth Observation System of Systems (GEOSS) Architecture Implementation Pilot in order to support the wide variety of demands that are primarily aimed at agriculture and water pollution monitoring by means of remote sensing.

  12. Compartment-specific pH monitoring in Bacillus subtilis using fluorescent sensor proteins; a tool to analyse the antibacterial effect of weak organic acids.

    Directory of Open Access Journals (Sweden)

    Johan W.A. van Beilen

    2013-06-01

    Full Text Available The internal pH (pHi of a living cell is one of its most important physiological parameters. To monitor the pH inside B. subtilis during various stages of its life cycle, we constructed an improved version (IpHluorin of the ratiometric, pH-sensitive fluorescent protein pHluorin by extending it at the 5’ end with the first 24 bp of comGA. The new version, which showed an approximate 40% increase in fluorescence intensity, was expressed from developmental phase-specific, native promoters of B. subtilis that are specifically active during vegetative growth on glucose (PptsG or during sporulation (PspoIIA, PspoIIID and PsspE. Our results show strong, compartment-specific expression of IpHluorin that allowed accurate pHi measurements of live cultures during exponential growth, early and late sporulation, spore germination, and during subsequent spore outgrowth. Dormant spores were characterised by an internal pH of 6.0 ± 0.3. Upon full germination the internal pH rose dependent on the medium to 7.0-7.4. The presence of sorbic acid in the germination medium inhibited a rise in the intracellular pH of germinating spores and inhibited germination. Such effects were absent when acetic was added at identical concentrations.

  13. Mechanical cavopulmonary assistance of a patient-specific Fontan physiology: numerical simulations, lumped parameter modeling, and suction experiments.

    Science.gov (United States)

    Throckmorton, Amy L; Carr, James P; Tahir, Sharjeel A; Tate, Ryan; Downs, Emily A; Bhavsar, Sonya S; Wu, Yi; Grizzard, John D; Moskowitz, William B

    2011-11-01

    This study investigated the performance of a magnetically levitated, intravascular axial flow blood pump for mechanical circulatory support of the thousands of Fontan patients in desperate need of a therapeutic alternative. Four models of the extracardiac, total cavopulmonary connection (TCPC) Fontan configuration were evaluated to formulate numerical predictions: an idealized TCPC, a patient-specific TCPC per magnetic resonance imaging data, and each of these two models having a blood pump in the inferior vena cava (IVC). A lumped parameter model of the Fontan physiology was used to specify boundary conditions. Pressure-flow characteristics, energy gain calculations, scalar stress levels, and blood damage estimations were executed for each model. Suction limitation experiments using the Sylgard elastomer tubing were also conducted. The pump produced pressures of 1-16 mm Hg for 2000-6000 rpm and flow rates of 0.5-4.5 L/min. The pump inlet or IVC pressure was found to decrease at higher rotational speeds. Maximum scalar stress estimations were 3 Pa for the nonpump models and 290 Pa for the pump-supported cases. The blood residence times for the pump-supported cases were shorter (0.9 s) as compared with the nonsupported configurations (2.5 s). However, the blood damage indices were higher (1.5%) for the anatomic model with pump support. The pump successfully augmented pressure in the TCPC junction and increased the hydraulic energy of the TCPC as a function of flow rate and rotational speed. The suction experiments revealed minimal deformation (<3%) at 9000 rpm. The findings of this study support the continued design and development of this blood pump.

  14. Noninvasive monitoring of placenta-specific transgene expression by bioluminescence imaging.

    Directory of Open Access Journals (Sweden)

    Xiujun Fan

    Full Text Available BACKGROUND: Placental dysfunction underlies numerous complications of pregnancy. A major obstacle to understanding the roles of potential mediators of placental pathology has been the absence of suitable methods for tissue-specific gene manipulation and sensitive assays for studying gene functions in the placentas of intact animals. We describe a sensitive and noninvasive method of repetitively tracking placenta-specific gene expression throughout pregnancy using lentivirus-mediated transduction of optical reporter genes in mouse blastocysts. METHODOLOGY/PRINCIPAL FINDINGS: Zona-free blastocysts were incubated with lentivirus expressing firefly luciferase (Fluc and Tomato fluorescent fusion protein for trophectoderm-specific infection and transplanted into day 3 pseudopregnant recipients (GD3. Animals were examined for Fluc expression by live bioluminescence imaging (BLI at different points during pregnancy, and the placentas were examined for tomato expression in different cell types on GD18. In another set of experiments, blastocysts with maximum photon fluxes in the range of 2.0E+4 to 6.0E+4 p/s/cm(2/sr were transferred. Fluc expression was detectable in all surrogate dams by day 5 of pregnancy by live imaging, and the signal increased dramatically thereafter each day until GD12, reaching a peak at GD16 and maintaining that level through GD18. All of the placentas, but none of the fetuses, analyzed on GD18 by BLI showed different degrees of Fluc expression. However, only placentas of dams transferred with selected blastocysts showed uniform photon distribution with no significant variability of photon intensity among placentas of the same litter. Tomato expression in the placentas was limited to only trophoblast cell lineages. CONCLUSIONS/SIGNIFICANCE: These results, for the first time, demonstrate the feasibility of selecting lentivirally-transduced blastocysts for uniform gene expression in all placentas of the same litter and early

  15. Protocol of specific health monitoring: ionizing radiation, 11 years later; Protocolo de vigilancia sanitaria especifica: radiaciones ionizantes, 11 anos despues

    Energy Technology Data Exchange (ETDEWEB)

    Castillejo Puertas, F. M.

    2016-08-01

    Since the approval on November 11{sup t}h 2003 of the Protocol of Specific Health Monitoring for Workers Exposed to Ionizing Radiation a study has been carried out to discover its effectiveness. These areas were examined: the daily practice od accupational medicine and, in particular, its specific task in the application of the different clinical/labour criteria for workers exposed to ionizing radiation or at risk of radioactive contamination; the degree of its uses as well as the updates and improvements. For that purpose, a descriptive bibliographic revision has been used for the last 11 years. The results revealed the lack of updates of the Protocol as well as the few usable objective criteria, when the clinical/labour aptitudes are reflected upon. (Author)

  16. Integrating hydrograph modeling with real-time flow monitoring to generate hydrograph-specific sampling schemes

    Science.gov (United States)

    Gall, Heather E.; Jafvert, Chad T.; Jenkinson, Byron

    2010-11-01

    Automated sample collection for water quality research and evaluation generally is performed by simple time-paced or flow-weighted sampling protocols. However, samples collected on strict time-paced or flow-weighted schemes may not adequately capture all elements of storm event hydrographs (i.e., rise, peak, and recession). This can result in inadequate information for calculating chemical mass flux over storm events. In this research, an algorithm was developed to guide automated sampling of hydrographs based on storm-specific information. A key element of the new "hydrograph-specific sampling scheme" is the use of a hydrograph recession model for predicting the hydrograph recession curve, during which flow-paced intervals are calculated for scheduling the remaining samples. The algorithm was tested at a tile drained Midwest agricultural site where real-time flow data were processed by a programmable datalogger that in turn activated an automated sampler at the appropriate sampling times to collect a total of twenty samples during each storm event independent of the number of sequential hydrographs generated. The utility of the algorithm was successfully tested with hydrograph data collected at both a tile drain and agricultural ditch, suggesting the potential for general applicability of the method. This sampling methodology is flexible in that the logic can be adapted for use with any hydrograph recession model; however, in this case a power law equation proved to be the most practical model.

  17. Species-specific identification from incomplete sampling: applying DNA barcodes to monitoring invasive solanum plants.

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    Full Text Available Comprehensive sampling is crucial to DNA barcoding, but it is rarely performed because materials are usually unavailable. In practice, only a few rather than all species of a genus are required to be identified. Thus identification of a given species using a limited sample is of great importance in current application of DNA barcodes. Here, we selected 70 individuals representing 48 species from each major lineage of Solanum, one of the most species-rich genera of seed plants, to explore whether DNA barcodes can provide reliable specific-species discrimination in the context of incomplete sampling. Chloroplast genes ndhF and trnS-trnG and the nuclear gene waxy, the commonly used markers in Solanum phylogeny, were selected as the supplementary barcodes. The tree-building and modified barcode gap methods were employed to assess species resolution. The results showed that four Solanum species of quarantine concern could be successfully identified through the two-step barcoding sampling strategy. In addition, discrepancies between nuclear and cpDNA barcodes in some samples demonstrated the ability to discriminate hybrid species, and highlights the necessity of using barcode regions with different modes of inheritance. We conclude that efficient phylogenetic markers are good candidates as the supplementary barcodes in a given taxonomic group. Critically, we hypothesized that a specific-species could be identified from a phylogenetic framework using incomplete sampling-through this, DNA barcoding will greatly benefit the current fields of its application.

  18. Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies

    Science.gov (United States)

    Zheng, Fang; Perlman, Harris; Matthys, Patrick; Wen, Yurong; Lahoutte, Tony; Muyldermans, Serge; Lu, Shemin; De Baetselier, Patrick; Schoonooghe, Steve; Devoogdt, Nick; Raes, Geert

    2016-01-01

    Single-photon emission computed tomography combined with micro-CT (SPECT/μCT) imaging using Nanobodies against complement receptor of the Ig superfamily (CRIg), found on tissue macrophages such as synovial macrophages, has promising potential to visualize joint inflammation in experimental arthritis. Here, we further addressed the specificity and assessed the potential for arthritis monitoring. Signals obtained with 99mTc-labelled NbV4m119 Nanobody were compared in joints of wild type (WT) versus CRIg−/− mice with collagen-induced arthritis (CIA) or K/BxN serum transfer-induced arthritis (STIA). In addition, SPECT/μCT imaging was used to investigate arthritis development in STIA and in CIA under dexamethasone treatment. 99mTc-NbV4m119 accumulated in inflamed joints of WT, but not CRIg−/− mice with CIA and STIA. Development and spontaneous recovery of symptoms in STIA was reflected in initially increased and subsequently reduced joint accumulation of 99mTc-NbV4m119. Dexamethasone treatment of CIA mice reduced 99mTc-NbV4m119 accumulation as compared to saline control in most joints except knees. SPECT/μCT imaging with 99mTc-NbV4m119 allows specific assessment of inflammation in different arthritis models and provides complementary information to clinical scoring for quantitatively and non-invasively monitoring the pathological process and the efficacy of arthritis treatment. PMID:27779240

  19. Evaluation for the Uncertainty of Multi-Parameter Monitor%多参数监护仪不确定度的评定

    Institute of Scientific and Technical Information of China (English)

    潘强

    2014-01-01

    The article analyzed the uncertainty of testing results of heart rate, non-invasive blood pressure and non-invasive SpO2 of multi-parameter monitor, so that the quality of multi-parameter monitor for clinical using can be controlled, to ensure the value transfer is accurate, reliable, guarantee the safety of clinical application.%文章对多参数监护仪的心率、无创血压、无创血氧饱和度测量结果不确定度进行了分析和评定,以便对临床使用的多参数监护仪的测量结果进行控制,保证量值传递的准确、可靠,保障临床使用的安全。

  20. Accurate Calculation of Hydration Free Energies using Pair-Specific Lennard-Jones Parameters in the CHARMM Drude Polarizable Force Field.

    Science.gov (United States)

    Baker, Christopher M; Lopes, Pedro E M; Zhu, Xiao; Roux, Benoît; Mackerell, Alexander D

    2010-03-01

    Lennard-Jones (LJ) parameters for a variety of model compounds have previously been optimized within the CHARMM Drude polarizable force field to reproduce accurately pure liquid phase thermodynamic properties as well as additional target data. While the polarizable force field resulting from this optimization procedure has been shown to satisfactorily reproduce a wide range of experimental reference data across numerous series of small molecules, a slight but systematic overestimate of the hydration free energies has also been noted. Here, the reproduction of experimental hydration free energies is greatly improved by the introduction of pair-specific LJ parameters between solute heavy atoms and water oxygen atoms that override the standard LJ parameters obtained from combining rules. The changes are small and a systematic protocol is developed for the optimization of pair-specific LJ parameters and applied to the development of pair-specific LJ parameters for alkanes, alcohols and ethers. The resulting parameters not only yield hydration free energies in good agreement with experimental values, but also provide a framework upon which other pair-specific LJ parameters can be added as new compounds are parametrized within the CHARMM Drude polarizable force field. Detailed analysis of the contributions to the hydration free energies reveals that the dispersion interaction is the main source of the systematic errors in the hydration free energies. This information suggests that the systematic error may result from problems with the LJ combining rules and is combined with analysis of the pair-specific LJ parameters obtained in this work to identify a preliminary improved combining rule.

  1. Comparison of Physiological Parameters and Anaesthesia Specific Observations during Isoflurane, Ketamine-Xylazine or Medetomidine-Midazolam-Fentanyl Anaesthesia in Male Guinea Pigs

    Science.gov (United States)

    Tacke, Sabine; Guth, Brian; Henke, Julia

    2016-01-01

    Guinea pigs (GPs) are difficult to anaesthetize successfully, the choices for anaesthesia are limited and physiological parameters are likely to be influenced substantially under anaesthesia. We implanted blood pressure radio-telemetry devices into 16 male GPs and subjected them to anaesthesia with ketamine-xylazine (KX), medetomidine-midazolam-fentanyl (MMF) or isoflurane (Iso, plus atropine premedication) in a randomized order with a 7 day interval between anaesthesias. Each anaesthesia lasted 40min, after which Iso was discontinued, MMF was fully antagonized with atipamezole-flumazenil-naloxone and KX was partially antagonized with atipamezole. Hemodynamics were recorded continuously for at least 240min after induction and the GPs were monitored for respiratory rate, reflex responses and specific observations until regaining of their righting reflex (RR). Blood for glucose testing was taken from the ear at 7.5, 20 and 40min during anaesthesia. Recovery time was short with MMF and Iso but long for KX. MMF induced only a transient blood pressure drop after antagonization, whereas Iso caused a marked hypotension during maintenance and KX led to moderate hypotension after antagonization. MMF and Iso produced tolerable heart rate changes, but KX led to long term post-anaesthetic bradycardia. Hypothermia occurred with all anaesthesias, but the GPs returned to normothermia the fastest under MMF, followed shortly by Iso. KX, however, caused a profound and prolonged hypothermia. The respiration was depressed with all anaesthesias, substantially with MMF (-41%) and KX (-52%) and severe during Iso maintenance (-71%). Blood glucose with MMF and KX increased throughout the anaesthesia, but the values remained within reference values with all anaesthetics. The reflex responses character and strength varied between the anaesthetics. In conclusion, MMF is the anaesthetic of choice and Iso may be used for short, non-painful procedures. We advise against the use of KX in GPs

  2. Modeling the Relationship between Vibration Features and Condition Parameters Using Relevance Vector Machines for Health Monitoring of Rolling Element Bearings under Varying Operation Conditions

    Directory of Open Access Journals (Sweden)

    Lei Hu

    2015-01-01

    Full Text Available Rotational speed and load usually change when rotating machinery works. Both this kind of changing operational conditions and machine fault could make the mechanical vibration characteristics change. Therefore, effective health monitoring method for rotating machinery must be able to adjust during the change of operational conditions. This paper presents an adaptive threshold model for the health monitoring of bearings under changing operational conditions. Relevance vector machines (RVMs are used for regression of the relationships between the adaptive parameters of the threshold model and the statistical characteristics of vibration features. The adaptive threshold model is constructed based on these relationships. The health status of bearings can be indicated via detecting whether vibration features exceed the adaptive threshold. This method is validated on bearings running at changing speeds. The monitoring results show that this method is effective as long as the rotational speed is higher than a relative small value.

  3. Junction temperature measurements via thermo-sensitive electrical parameters and their application to condition monitoring and active thermal control of power converters

    DEFF Research Database (Denmark)

    Baker, Nick; Liserre, Marco; Dupont, L.

    2013-01-01

    implementation of active thermal control to reduce losses and increase lifetime can be performed given an accurate knowledge of temperature. Temperature measurements via thermo-sensitive electrical parameters (TSEP) are one way to carry out immediate temperature readings on fully packaged devices. However...... scale implementation of these methods are discussed. Their potential use in the aforementioned goals in condition monitoring and active thermal control is also described....

  4. Real-time Monitoring of Non-specific Toxicity Using a Saccharomyces cerevisiae Reporter System

    Directory of Open Access Journals (Sweden)

    Matti Karp

    2008-10-01

    Full Text Available Baker’s yeast, Saccharomyces cerevisiae, is the simplest and most well-known representative of eukaryotic cells and thus a convenient model organism for evaluating toxic effects in human cells and tissues. Yeast cell sensors are easy to maintain with short generation times, which makes the analytical method of assessing antifungal toxicity cheap and less-time consuming. In this work, the toxicity of test compounds was assessed in bioassays based on bioluminescence inhibition and on traditional growth inhibition on agar plates. The model organism in both tests was a modified S. cerevisiae sensor strain that produces light when provided with D-luciferin in an insect luciferase reporter gene activity assay. The bioluminescence assay showed toxic effects for yeast cell sensor of 5,6-benzo-flavone, rapamycin, nystatin and cycloheximide at concentrations of nM to µM. In addition, arsenic compounds, cadmium chloride, copper sulfate and lead acetate were shown to be potent non-specific inhibitors of the reporter organism described here. The results from a yeast agar diffusion assay correlated with the bioluminescence assay results.

  5. Parameters of a simple whole body counter and thyroid monitor established at the Dresden Felsenkeller underground laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Sahre, P. [Rossendorf Nuclear Engineering and Analytics, Inc., Dresden (Germany); Schoenmuth, T. [Rossendorf Nuclear Engineering and Analytics, Inc., Dresden (Germany)

    1997-03-01

    At the Rossendorf Nuclear Engineering and Analytics Inc. a simple whole body counter and an iodine-thyroid monitor are used for measuring the internal contamination of workers. There is no shielding chamber in both cases. By using the chamber at the Dresden Felsenkeller underground laboratory the lower limit of detection could be improved by a factor of about 3 for whole body counting and by a factor of 2,5 for thyroid monitoring (I 131, I 125). Concerning the lower limit of detection the applicability of the German standard DIN 25 482 implemented in the Gamma-Vision software packadge is discussed in the paper. (orig.)

  6. HadISDH: an updated land surface specific humidity product for climate monitoring

    Directory of Open Access Journals (Sweden)

    K. M. Willett

    2012-10-01

    Full Text Available Presented herein is HadISDH: an annually-updated near-global land-surface specific humidity product providing monthly means from 1973 onwards over large scale grids. HadISDH is an update to the land component of HadCRUH utilising the global high resolution land surface station product HadISD as a basis. HadISD, in turn uses an updated version of NOAA's integrated surface database. Intensive automated quality control has been undertaken at the synoptic level, as part of HadISD processing. The data have been subsequently run through the pairwise homogenisation algorithm developed for NCDC's GHCN Monthly temperature product. Uncertainty estimates including station uncertainty and sampling uncertainty are provided at the gridbox spatial scale and monthly time scale.

    HadISDH is in good agreement with existing land surface humidity products in periods of overlap. Widespread moistening is shown over the 1973–2011 period. The largest moistening signals are over the tropics with drying over the subtropics, supporting other evidence of an intensified hydrological cycle over recent years. Moistening is detectable with high (95% confidence over large-scale averages for the globe, Northern Hemisphere and tropics with trends of 0.095 (0.086 to 0.105 g kg−1 per decade, 0.091 (0.08 to 0.103 g kg−1 per decade and 0.147 (0.133 to 0.162 g kg−1 per decade, respectively. No change (0.008 (−0.011 to 0.028 g kg−1 per decade is detectable in the Southern Hemisphere. When globally averaged, 1998 was the moistest year since records began in 1973, closely followed by 2010, two strong El Niño years.

  7. Roughness Parameters Calculation By Means Of On-Line Vibration Monitoring Emerging From AWJ Interaction With Material

    Directory of Open Access Journals (Sweden)

    Hreha Pavol

    2015-06-01

    Full Text Available The paper deals with a study of relations between the measured Ra, Rq, Rz surface roughness parameters, the traverse speed of cutting head v and the vibration parameters, PtP, RMS, vRa, generated during abrasive water jet cutting of the AISI 309 stainless steel. Equations for prediction of the surface roughness parameters were derived according to the vibration parameter and the traverse speed of cutting head. Accuracy of the equations is described according to the Euclidean distances. The results are suitable for an on-line control model simulating abrasive water jet cutting and machining using an accompanying physical phenomenon for the process control which eliminates intervention of the operator.

  8. Hyperspectral remote sensing for monitoring species-specific drought impacts in southern California

    Science.gov (United States)

    Coates, Austin Reece

    be invaluable in the years to come. This study also intends to be used as a benchmark to show how specific species of plants are being affected by a prolonged drought. The research performed in this study will provide a reference point for analysis of future droughts.

  9. Cardiac Acceleration at the Onset of Exercise : A Potential Parameter for Monitoring Progress During Physical Training in Sports and Rehabilitation

    NARCIS (Netherlands)

    Hettinga, Florentina J.; Monden, Paul G.; van Meeteren, Nico L. U.; Daanen, Hein A. M.

    There is a need for easy-to-use methods to assess training progress in sports and rehabilitation research. The present review investigated whether cardiac acceleration at the onset of physical exercise (HRonset) can be used as a monitoring variable. The digital databases of Scopus and PubMed were

  10. Cardiac acceleration at the onset of exercise: A potential parameter for monitoring progress during physical training in sports and rehabilitation

    NARCIS (Netherlands)

    Hettinga, F.J.; Monden, P.G.; Meeteren, N.L.U. van; Daanen, H.A.M.

    2014-01-01

    There is a need for easy-to-use methods to assess training progress in sports and rehabilitation research. The present review investigated whether cardiac acceleration at the onset of physical exercise (HRonset) can be used as a monitoring variable. The digital databases of Scopus and PubMed were

  11. 40 CFR 63.4568 - What are the requirements for continuous parameter monitoring system installation, operation, and...

    Science.gov (United States)

    2010-07-01

    ... caused in part by poor maintenance or careless operation are not malfunctions. Any period for which the... install a device to monitor pressure drop across the zeolite wheel or rotary carbon bed. The pressure... simulations or via relative accuracy testing. (v) Conduct an accuracy audit every quarter and after every...

  12. RESULTS OF RADIATION-HYGIENIC MONITORING OF THE BASIC PARAMETERS OF THE HUMAN ENVIRONMENT IN THE KIROV REGION

    Directory of Open Access Journals (Sweden)

    B. N. Skolotnev

    2012-01-01

    Full Text Available The paper describes the experience of the laboratory of radiation monitoring in the the Kirov region since 1963. The results of long-term measurements of the environmental objects are presented. Gamma background measurement and investigation of radionuclides’ content in depositions are compared as methods for radioactive contamination assessment.

  13. Cardiac Acceleration at the Onset of Exercise : A Potential Parameter for Monitoring Progress During Physical Training in Sports and Rehabilitation

    NARCIS (Netherlands)

    Hettinga, Florentina J.; Monden, Paul G.; van Meeteren, Nico L. U.; Daanen, Hein A. M.

    2014-01-01

    There is a need for easy-to-use methods to assess training progress in sports and rehabilitation research. The present review investigated whether cardiac acceleration at the onset of physical exercise (HRonset) can be used as a monitoring variable. The digital databases of Scopus and PubMed were se

  14. Enhanced forensic discrimination of pollutants by position-specific isotope analysis using isotope ratio monitoring by (13)C nuclear magnetic resonance spectrometry.

    Science.gov (United States)

    Julien, Maxime; Nun, Pierrick; Höhener, Patrick; Parinet, Julien; Robins, Richard J; Remaud, Gérald S

    2016-01-15

    In forensic environmental investigations the main issue concerns the inference of the original source of the pollutant for determining the liable party. Isotope measurements in geochemistry, combined with complimentary techniques for contaminant identification, have contributed significantly to source determination at polluted sites. In this work we have determined the intramolecular (13)C profiles of several molecules well-known as pollutants. By giving additional analytical parameters, position-specific isotope analysis performed by isotope ratio monitoring by (13)C nuclear magnetic resonance (irm-(13)C NMR) spectrometry gives new information to help in answering the major question: what is the origin of the detected contaminant? We have shown that isotope profiling of the core of a molecule reveals both the raw materials and the process used in its manufacture. It also can reveal processes occurring between the contamination site 'source' and the sampling site. Thus, irm-(13)C NMR is shown to be a very good complement to compound-specific isotope analysis currently performed by mass spectrometry for assessing polluted sites involving substantial spills of pollutant.

  15. Wireless Sensor Network for Wearable Physiological Monitoring

    OpenAIRE

    P. S. Pandian; K. P. Safeer; Pragati Gupta; D. T. Shakunthala; B. S. Sundersheshu; V. C. Padaki

    2008-01-01

    Wearable physiological monitoring system consists of an array of sensors embedded into the fabric of the wearer to continuously monitor the physiological parameters and transmit wireless to a remote monitoring station. At the remote monitoring station the data is correlated to study the overall health status of the wearer. In the conventional wearable physiological monitoring system, the sensors are integrated at specific locations on the vest and are interconnected to the wearable data acqui...

  16. Real-time monitoring of specific oxygen uptake rates of embryonic stem cells in a microfluidic cell culture device.

    Science.gov (United States)

    Super, Alexandre; Jaccard, Nicolas; Cardoso Marques, Marco Paulo; Macown, Rhys Jarred; Griffin, Lewis Donald; Veraitch, Farlan Singh; Szita, Nicolas

    2016-09-01

    Oxygen plays a key role in stem cell biology as a signaling molecule and as an indicator of cell energy metabolism. Quantification of cellular oxygen kinetics, i.e. the determination of specific oxygen uptake rates (sOURs), is routinely used to understand metabolic shifts. However current methods to determine sOUR in adherent cell cultures rely on cell sampling, which impacts on cellular phenotype. We present real-time monitoring of cell growth from phase contrast microscopy images, and of respiration using optical sensors for dissolved oxygen. Time-course data for bulk and peri-cellular oxygen concentrations obtained for Chinese hamster ovary (CHO) and mouse embryonic stem cell (mESCs) cultures successfully demonstrated this non-invasive and label-free approach. Additionally, we confirmed non-invasive detection of cellular responses to rapidly changing culture conditions by exposing the cells to mitochondrial inhibiting and uncoupling agents. For the CHO and mESCs, sOUR values between 8 and 60 amol cell(-1) s(-1) , and 5 and 35 amol cell(-1) s(-1) were obtained, respectively. These values compare favorably with literature data. The capability to monitor oxygen tensions, cell growth, and sOUR, of adherent stem cell cultures, non-invasively and in real time, will be of significant benefit for future studies in stem cell biology and stem cell-based therapies.

  17. Development Of An Electronic Nose For Environmental Monitoring: Detection Of Specific Environmentally Important Gases At Their Odor Detection Threshold Concentration

    Science.gov (United States)

    Dentoni, Licinia; Capelli, Laura; Sironi, Selena; Del Rosso, Renato; Centola, Paolo; Della Torre, Matteo; Demattè, Fabrizio

    2011-09-01

    The use of a sensor array is demonstrated to be an effective approach to evaluate hazardous odor (or gas) emissions from industrial sites1. Therefore the possibility to use electronic noses for the prolonged survey of odor emissions from industrial sites is of particular interest for environmental monitoring purposes2. At the Olfactometric Laboratory of the Politecnico di Milano, in collaboration with Sacmi Group, Imola, an innovative electronic nose for the continuous monitoring of environmental odors is being developed. The aim of this work is to show the laboratory tests conducted to evaluate the capability of the electronic nose to recognize some specific environmentally important gases at their odor detection threshold concentration. The laboratory studies up to now focused on ammonia and butyric acid, those being compounds that can typically be found in the emissions from waste treatment plants, that may cause health effects when they exceed a given concentration level. The laboratory tests proved the sensors to be sensitive towards the considered compounds and the system to be capable of discriminating between odorous or non-odorous air, with a detection limit comparable with the detection limit of human nose.

  18. Arctic BioMap: Building Participatory Technologies for Community-Specific Environmental Monitoring and Decision Making in the North

    Science.gov (United States)

    Murray, M. S.; Panikkar, B.; Liang, S.; Kutz, S.

    2016-12-01

    The Arctic continues to undergo unprecedented and accelerated system-wide environmental change. For people who live in the north this presents challenges to resource management, subsistence, health and well-being, and yet, there is very little community-specific data on wildlife (including wildlife health), local environmental conditions and emerging hazards in Northern Canada. A novel approach that integrates community expertise with developing technologies can simplify data collection and improve understanding of current and future conditions. It can also improve our ability to manage and adapt to the rapidly transforming Arctic. Arctic BioMap is a data platform for real-time monitoring and a geospatial informational database of wildlife and environmental information useful for assessment, research, management, and education. It enables monitoring of wildlife and environmental variables including hazards to inform decision-making at multiples scales. Using participatory technologies Arctic BioMap incorporates indigenous research needs and the ensuing data can be used to inform policy making. Arctic BioMap provides a forum for continuous exchange and communication among community members, scientists, resources managers, and other stakeholders.

  19. Groundwater level and specific conductance monitoring at Marine Corps Base, Camp Lejeune, Onslow County, North Carolina, 2007-2008

    Science.gov (United States)

    McSwain, Kristen Bukowski

    2010-01-01

    The U.S. Geological Survey, in cooperation with the Marine Corps Base, Camp Lejeune, monitored water-resources conditions in the surficial, Castle Hayne, Peedee, and Black Creek aquifers in Onslow County, North Carolina, from November 2007 through September 2008. To comply with North Carolina Central Coastal Plain Capacity Use Area regulations, large-volume water suppliers in Onslow County must reduce their dependency on the Black Creek aquifer as a water-supply source and have, instead, proposed using the Castle Hayne aquifer as an alternative water-supply source. The Marine Corps Base, Camp Lejeune, uses water obtained from the unregulated surficial and Castle Hayne aquifers for drinking-water supply. Water-level data were collected and field measurements of physical properties were made at 19 wells at 8 locations spanning the Marine Corps Base, Camp Lejeune. These wells were instrumented with near real-time monitoring equipment to collect hourly measurements of water level. Additionally, specific conductance and water temperature were measured hourly in 16 of the 19 wells. Graphs are presented relating altitude of groundwater level to water temperature and specific conductance measurements collected during the study, and the relative vertical gradients between aquifers are discussed. The period-of-record normal (25th to 75th percentile) monthly mean groundwater levels at two well clusters were compared to median monthly mean groundwater levels at these same well clusters for 2008 to determine groundwater-resources conditions. In 2008, water levels were below normal in the 3 wells at one of the well clusters and were normal in 4 wells at the other cluster.

  20. Improved Control Of cheese Manufacture Through continuous Vat Monitoring Of Coagulation Parameters Using The Hot Wire Method

    OpenAIRE

    LeFevre, Michael John

    1995-01-01

    The hot wire method, with pH and temperature sensors, was evaluated to determine its usefulness and application for cheese production automation. Coagulation of milk substrate was measured with the hot wire instrument and by four other methods: Formagraph, Brookfield®, vixcometer, Omnispec™ bioactivity monitor, and Sommer and Matsen rolling bottle method. The hot wire, using the time at maximum slope, detected coagulation before methods that measure resistance to shear, and after methods that...

  1. Analysis of a Kalman filter based method for on-line estimation of atmospheric dispersion parameters using radiation monitoring data

    DEFF Research Database (Denmark)

    Drews, Martin; Lauritzen, Bent; Madsen, Henrik

    2005-01-01

    parameters, and the observables are linked to the state variables through a static measurement equation. The method is analysed for three simple state space models using experimental data obtained at a nuclear research reactor. Compared to direct measurements of the atmospheric dispersion, the Kalman filter...... estimates are found to agree well with the measured parameters, provided that the radiation measurements are spread out in the cross-wind direction. For less optimal detector placement it proves difficult to distinguish variations in the source term and plume height; yet the Kalman filter yields consistent...... scheme are outlined, to account for realistic accident scenarios....

  2. Gestation-Specific Changes in the Anatomy and Physiology of Healthy Pregnant Women: An Extended Repository of Model Parameters for Physiologically Based Pharmacokinetic Modeling in Pregnancy.

    Science.gov (United States)

    Dallmann, André; Ince, Ibrahim; Meyer, Michaela; Willmann, Stefan; Eissing, Thomas; Hempel, Georg

    2017-04-11

    In the past years, several repositories for anatomical and physiological parameters required for physiologically based pharmacokinetic modeling in pregnant women have been published. While providing a good basis, some important aspects can be further detailed. For example, they did not account for the variability associated with parameters or were lacking key parameters necessary for developing more detailed mechanistic pregnancy physiologically based pharmacokinetic models, such as the composition of pregnancy-specific tissues. The aim of this meta-analysis was to provide an updated and extended database of anatomical and physiological parameters in healthy pregnant women that also accounts for changes in the variability of a parameter throughout gestation and for the composition of pregnancy-specific tissues. A systematic literature search was carried out to collect study data on pregnancy-related changes of anatomical and physiological parameters. For each parameter, a set of mathematical functions was fitted to the data and to the standard deviation observed among the data. The best performing functions were selected based on numerical and visual diagnostics as well as based on physiological plausibility. The literature search yielded 473 studies, 302 of which met the criteria to be further analyzed and compiled in a database. In total, the database encompassed 7729 data. Although the availability of quantitative data for some parameters remained limited, mathematical functions could be generated for many important parameters. Gaps were filled based on qualitative knowledge and based on physiologically plausible assumptions. The presented results facilitate the integration of pregnancy-dependent changes in anatomy and physiology into mechanistic population physiologically based pharmacokinetic models. Such models can ultimately provide a valuable tool to investigate the pharmacokinetics during pregnancy in silico and support informed decision making regarding

  3. 40 CFR Table 3 to Subpart Ec of... - Operating Parameters To Be Monitored and Minimum Measurement and Recording Frequencies

    Science.gov (United States)

    2010-07-01

    ... flow rate Hourly 1×hour ✔ ✔ Minimum pressure drop across the wet scrubber or minimum horsepower or... scrubber followed by fabric filter Wet scrubber Dry scrubber followed by fabric filter and wet scrubber Maximum operating parameters: Maximum charge rate Continuous 1×hour ✔ ✔ ✔ Maximum fabric filter...

  4. 40 CFR Table 3 to Subpart Hhh of... - Operating Parameters To Be Monitored and Minimum Measurement and Recording Frequencies

    Science.gov (United States)

    2010-07-01

    ... mercury (Hg) sorbent flow rate Hourly Once per hour ✔ ✔ Minimum pressure drop across the wet scrubber or... rural HMIWI HMIWI a with dry scrubber followed by fabric filter HMIWI a with wet scrubber HMIWI a with dry scrubber followed by fabric filter and wet scrubber Maximum operating parameters: Maximum...

  5. Evaluation of the Influence of Sensor Geometry and Physical Parameters on Impedance-Based Structural Health Monitoring

    Directory of Open Access Journals (Sweden)

    L.V. Palomino

    2012-01-01

    Full Text Available Structural Health Monitoring (SHM is the process of damage identification in mechanical structures that encompasses four main phases: damage detection, damage localization, damage extent evaluation and prognosis of residual life. Among various existing SHM techniques, the one based on electromechanical impedance measurements has been considered as one of the most effective, especially in the identification of incipient damage. This method measures the variation of the electromechanical impedance of the structure as caused by the presence of damage by using piezoelectric transducers bonded on the surface of the structure (or embedded into it. The most commonly used smart material in the context of the present contribution is the lead zirconate titanate (PZT. Through these piezoceramic sensor-actuators, the electromechanical impedance, which is directly related to the mechanical impedance of the structure, is obtained as a frequency domain dynamic response. Based on the variation of the impedance signals, the presence of damage can be detected. A particular damage metric can be used to quantify the damage. For the success of the monitoring procedure, the measurement system should be robust enough with respect to environmental influences from different sources, in such a way that correct and reliable decisions can be made based on the measurements. The environmental influences become more critical under certain circumstances, especially in aerospace applications, in which extreme conditions are frequently encountered. In this paper, the influence of electromagnetic radiation, temperature and pressure variations, and ionic environment have been examined in laboratory. In this context, the major concern is to determine if the impedance responses are affected by these influences. In addition, the sensitivity of the method with respect to the shape of the PZT patches is evaluated. Conclusions are drawn regarding the monitoring efficiency, stability and

  6. Determination of two-liquid mixture composition by assessing its dielectric parameters 2. modified measuring system for monitoring the dehydration process of bioethanol production

    Science.gov (United States)

    Vilitis, O.; Shipkovs, P.; Merkulovs, D.; Rucins, A.; Zihmane-Ritina, K.; Bremers, G.

    2014-02-01

    In Part 2 of the work we describe a modified measuring system for precise monitoring of the dehydration process of bioethanol production. This is based on the earlier proposed system for measuring the concentration of solutions and two-liquid mixtures using devices with capacitive sensors (1-300pF), which provides a stable measuring resolution of ± 0.005 pF at measuring the capacitance of a sensor. In this part of our work we determine additional requirements that are to be imposed on the measuring system at monitoring the ethanol dehydration process and control of bioethanol production. The most important parameters of the developed measuring system are identified. An exemplary calculation is given for the thermocompensated calibration of measuring devices. The results of tests have shown a good performance of the developed measuring system.

  7. Determination of two-liquid mixture composition by assessing its dielectric parameters 2. modified measuring system for monitoring the dehydration process of bioethanol production

    Directory of Open Access Journals (Sweden)

    Vilitis O.

    2014-02-01

    Full Text Available In Part 2 of the work we describe a modified measuring system for precise monitoring of the dehydration process of bioethanol production. This is based on the earlier proposed system for measuring the concentration of solutions and two-liquid mixtures using devices with capacitive sensors (1-300pF, which provides a stable measuring resolution of ± 0.005 pF at measuring the capacitance of a sensor. In this part of our work we determine additional requirements that are to be imposed on the measuring system at monitoring the ethanol dehydration process and control of bioethanol production. The most important parameters of the developed measuring system are identified. An exemplary calculation is given for the thermocompensated calibration of measuring devices. The results of tests have shown a good performance of the developed measuring system.

  8. Sensitivity of the model error parameter specification in weak-constraint four-dimensional variational data assimilation

    Science.gov (United States)

    Shaw, Jeremy A.; Daescu, Dacian N.

    2017-08-01

    This article presents the mathematical framework to evaluate the sensitivity of a forecast error aspect to the input parameters of a weak-constraint four-dimensional variational data assimilation system (w4D-Var DAS), extending the established theory from strong-constraint 4D-Var. Emphasis is placed on the derivation of the equations for evaluating the forecast sensitivity to parameters in the DAS representation of the model error statistics, including bias, standard deviation, and correlation structure. A novel adjoint-based procedure for adaptive tuning of the specified model error covariance matrix is introduced. Results from numerical convergence tests establish the validity of the model error sensitivity equations. Preliminary experiments providing a proof-of-concept are performed using the Lorenz multi-scale model to illustrate the theoretical concepts and potential benefits for practical applications.

  9. Investigation of Parameters that Affect the Success Rate of Microarray-Based Allele-Specific Hybridization Assays

    DEFF Research Database (Denmark)

    Poulsen, Lena; Søe, Martin Jensen; Moller, Lisbeth Birk

    2011-01-01

    Background: The development of microarray-based genetic tests for diseases that are caused by known mutations is becoming increasingly important. The key obstacle to developing functional genotyping assays is that such mutations need to be genotyped regardless of their location in genomic regions...... buffers with different stringencies in a custom-made microfluidic system. The data were used to assess which parameters play significant roles in assay development. Conclusions: Several assay development methods found suitable probes and assay conditions for a functional test for all investigated mutation...... sites. Probe length, probe spacer length, and assay stringency sufficed as variable parameters in the search for a functional multiplex assay. We discuss the optimal assay development methods for several different scenarios....

  10. The Effect of Patient-Specific Cerebral Oxygenation Monitoring on Postoperative Cognitive Function: A Multicenter Randomized Controlled Trial

    Science.gov (United States)

    Ellis, Lucy; Murphy, Gavin J; Culliford, Lucy; Dreyer, Lucy; Clayton, Gemma; Downes, Richard; Nicholson, Eamonn; Stoica, Serban; Reeves, Barnaby C

    2015-01-01

    Background Indices of global tissue oxygen delivery and utilization such as mixed venous oxygen saturation, serum lactate concentration, and arterial hematocrit are commonly used to determine the adequacy of tissue oxygenation during cardiopulmonary bypass (CPB). However, these global measures may not accurately reflect regional tissue oxygenation and ischemic organ injury remains a common and serious complication of CPB. Near-infrared spectroscopy (NIRS) is a noninvasive technology that measures regional tissue oxygenation. NIRS may be used alongside global measures to optimize regional perfusion and reduce organ injury. It may also be used as an indicator of the need for red blood cell transfusion in the presence of anemia and tissue hypoxia. However, the clinical benefits of using NIRS remain unclear and there is a lack of high-quality evidence demonstrating its efficacy and cost effectiveness. Objective The aim of the patient-specific cerebral oxygenation monitoring as part of an algorithm to reduce transfusion during heart valve surgery (PASPORT) trial is to determine whether the addition of NIRS to CPB management algorithms can prevent cognitive decline, postoperative organ injury, unnecessary transfusion, and reduce health care costs. Methods Adults aged 16 years or older undergoing valve or combined coronary artery bypass graft and valve surgery at one of three UK cardiac centers (Bristol, Hull, or Leicester) are randomly allocated in a 1:1 ratio to either a standard algorithm for optimizing tissue oxygenation during CPB that includes a fixed transfusion threshold, or a patient-specific algorithm that incorporates cerebral NIRS monitoring and a restrictive red blood cell transfusion threshold. Allocation concealment, Internet-based randomization stratified by operation type and recruiting center, and blinding of patients, ICU and ward care staff, and outcome assessors reduce the risk of bias. The primary outcomes are cognitive function 3 months after

  11. Analysis and detection of functional outliers in water quality parameters from different automated monitoring stations in the Nalón river basin (Northern Spain).

    Science.gov (United States)

    Piñeiro Di Blasi, J I; Martínez Torres, J; García Nieto, P J; Alonso Fernández, J R; Díaz Muñiz, C; Taboada, J

    2015-01-01

    The purposes and intent of the authorities in establishing water quality standards are to provide enhancement of water quality and prevention of pollution to protect the public health or welfare in accordance with the public interest for drinking water supplies, conservation of fish, wildlife and other beneficial aquatic life, and agricultural, industrial, recreational, and other reasonable and necessary uses as well as to maintain and improve the biological integrity of the waters. In this way, water quality controls involve a large number of variables and observations, often subject to some outliers. An outlier is an observation that is numerically distant from the rest of the data or that appears to deviate markedly from other members of the sample in which it occurs. An interesting analysis is to find those observations that produce measurements that are different from the pattern established in the sample. Therefore, identification of atypical observations is an important concern in water quality monitoring and a difficult task because of the multivariate nature of water quality data. Our study provides a new method for detecting outliers in water quality monitoring parameters, using turbidity, conductivity and ammonium ion as indicator variables. Until now, methods were based on considering the different parameters as a vector whose components were their concentration values. This innovative approach lies in considering water quality monitoring over time as continuous curves instead of discrete points, that is to say, the dataset of the problem are considered as a time-dependent function and not as a set of discrete values in different time instants. This new methodology, which is based on the concept of functional depth, was applied to the detection of outliers in water quality monitoring samples in the Nalón river basin with success. Results of this study were discussed here in terms of origin, causes, etc. Finally, the conclusions as well as advantages of

  12. Development of a web-based monitoring system using operation parameters for the main component in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Son, Dong Chan; An, Kung Il; Hong, Suk Young; Lee, Jeong Soo; Jung, Duk Jin; Shin, Sun Hee; Son, So Hee [Daesang Information Technology Co., Ltd., Seoul (Korea, Republic of)

    2004-02-15

    The frequency of the damage is increasing, which is caused by the fatigue, according to the increase of running of nuclear power plants. So we need to acquire the reliance of design data to estimate the fatigue and damage of major machinery that might happen as time-dependent crack growth characterization. The research is focused on keeping operating record of nuclear power plants about major machinery which consists of a nuclear reactor pressure boarder on each excessive operating condition including normal operating and extraordinary operating by estimating fracture mechanical movements on real time and fatigue about major nuclear power plants machinery, which are acquired the pressure and temperature data. For further details about the scope and contents of R and D are following. Development of H/W that is necessary to acquire operating real time data of heating and hydraulic power. Selection of a safety variable about major system by each type (the four NPP, all unit). Communication protocol development for connecting between CARE system data base server and fatigue monitoring system data base server. Development of connecting database for controlling and storing of heating and hydraulic power operating data. Real time monitoring system development based on Web using JAVA.

  13. Definition of a parameter for a typical specific absorption rate under real boundary conditions of cellular phones in a GSM networkd

    Directory of Open Access Journals (Sweden)

    D. Gerhardt

    2003-01-01

    Full Text Available Using cellular phones the specific absorption rate (SAR as a physical value must observe established and internationally defined levels to guarantee human protection. To assess human protection it is necessary to guarantee safety under worst-case conditions (especially maximum transmitting power using cellular phones. To evaluate the exposure to electromagnetic fields under normal terms of use of cellular phones the limitations of the specific absorption rate must be pointed out. In a mobile radio network normal terms of use of cellular phones, i.e. in interconnection with a fixed radio transmitter of a mobile radio network, power control of the cellular phone as well as the antenna diagram regarding a head phantom are also significant for the real exposure. Based on the specific absorption rate, the antenna diagram regarding a head phantom and taking into consideration the power control a new parameter, the typical absorption rate (SARtyp, is defined in this contribution. This parameter indicates the specific absorption rate under average normal conditions of use. Constant radio link attenuation between a cellular phone and a fixed radio transmitter for all mobile models tested was assumed in order to achieve constant field strength at the receiving antenna of the fixed radio transmitter as a result of power control. The typical specific absorption rate is a characteristic physical value of every mobile model. The typical absorption rate was calculated for 16 different mobile models and compared with the absorption rate at maximum transmitting power. The results confirm the relevance of the definition of this parameter (SARtyp as opposed to the specific absorption rate as a competent and applicable method to establish the real mean exposure from a cellular phone in a mobile radio network. The typical absorption rate provides a parameter to assess electromagnetic fields of a cellular phone that is more relevant to the consumer.

  14. Cardiac acceleration at the onset of exercise: a potential parameter for monitoring progress during physical training in sports and rehabilitation.

    Science.gov (United States)

    Hettinga, Florentina J; Monden, Paul G; van Meeteren, Nico L U; Daanen, Hein A M

    2014-05-01

    There is a need for easy-to-use methods to assess training progress in sports and rehabilitation research. The present review investigated whether cardiac acceleration at the onset of physical exercise (HRonset) can be used as a monitoring variable. The digital databases of Scopus and PubMed were searched to retrieve studies investigating HRonset. In total 652 studies were retrieved. These articles were then classified as having emphasis on HRonset in a sports or rehabilitation setting, which resulted in 8 of 112 studies with a sports application and 6 of 68 studies with a rehabilitation application that met inclusion criteria. Two co-existing mechanisms underlie HRonset: feedforward (central command) and feedback (mechanoreflex, metaboreflex, baroreflex) control. A number of studies investigated HRonset during the first few seconds of exercise (HRonsetshort), in which central command and the mechanoreflex determine vagal withdrawal, the major mechanism by which heart rate (HR) increases. In subsequent sports and rehabilitation studies, interest focused on HRonset during dynamic exercise over a longer period of time (HRonsetlong). Central command, mechanoreflexes, baroreflexes, and possibly metaboreflexes contribute to HRonset during the first seconds and minutes of exercise, which in turn leads to further vagal withdrawal and an increase in sympathetic activity. HRonset has been described as the increase in HR compared with resting state (delta HR) or by exponential modeling, with measurement intervals ranging from 0-4 s up to 2 min. Delta HR was used to evaluate HRonsetshort over the first 4 s of exercise, as well as for analyzing HRonsetlong. In exponential modeling, the HR response to dynamic exercise is biphasic, consisting of fast (parasympathetic, 0-10 s) and slow (sympathetic, 1-4 min) components. Although available studies differed largely in measurement protocols, cross-sectional and longitudinal training studies showed that studies analyzing HRonset

  15. A dose titration study on the effect of virginiamycin on specific blood parameters and milk quality in the sow.

    Science.gov (United States)

    Alexopoulos, C; Tsinas, A; Kantas, D; Florou-Paneri, P; Read, M P; Vassilopoulos, V; Kyriakis, S C

    1998-11-01

    The present study investigates the changes in blood cholesterol and total lipids concentrations, as well as changes in milk fat, protein, lactose and total solids content of sows after the long-term administration of virginiamycin (VM) in the feed. Seventy-two (72) healthy Dalland gilts, in 18 groups of four (2 + 2) siblings were used in total. The gilts of each group of siblings were randomly allocated to one of the following four dietary treatments: VM0 = negative control, virginiamycin 0 mg/kg, VM20 = virginiamycin 20 mg/kg feed, VM40 = virginiamycin 40 mg/kg feed and VM60 = virginiamycin 60 mg/kg of feed. Treatments started at the age of 6 months covering three complete breeding cycles (up to the third weaning). The first eight groups of siblings (eight gilts per treatment/32 gilts in total) were used for blood sampling (blood group), while the remaining 10 groups of siblings (10 gilts per treatment/40 gilts in total) were used for milk sampling (milk group). Feeds given at insemination, pregnancy and lactation did not contain any other antibacterial or performance enhancer. The results indicate that all three levels of VM supplementation of gilt/sow feed influenced certain blood parameters by increasing (P < 0.05) both cholesterol and total lipids concentrations on the 30th and 60th day of each pregnancy, at each farrowing and at each weaning. The effect of dietary VM on these blood parameters remained constant throughout three consecutive parities. Moreover, the results indicate a beneficial effect of dietary VM on the milk quality of the sows during the third lactation by increasing (P < 0.05) (i) the mean fat content, (ii) the mean protein content, (iii) the mean lactose content and (iv) the mean total solids content. The highest (P < 0.05) levels in both blood and milk parameters were noticed at the inclusion level of 40 mg/kg of feed.

  16. 40 CFR 75.17 - Specific provisions for monitoring emissions from common, bypass, and multiple stacks for NOX...

    Science.gov (United States)

    2010-07-01

    ... chooses to monitor in the ducts rather than the stack, the owner or operator shall monitor the NOX... NOX emission rate at the unit level, in lieu of installing flow monitors on each stack or duct. If... emissions from common, bypass, and multiple stacks for NOX emission rate. 75.17 Section 75.17 Protection...

  17. Development of an SPME-GC-MS method for the specific quantification of dimethylamine and trimethylamine: use of a new ratio for the freshness monitoring of cod fillets.

    Science.gov (United States)

    Dehaut, Alexandre; Duthen, Simon; Grard, Thierry; Krzewinski, Frédéric; N'Guessan, Assi; Brisabois, Anne; Duflos, Guillaume

    2016-08-01

    Fish is a highly perishable food, so it is important to be able to estimate its freshness to ensure optimum quality for consumers. The present study describes the development of an SPME-GC-MS technique capable of quantifying both trimethylamine (TMA) and dimethylamine (DMA), components of what has been defined as partial volatile basic nitrogen (PVB-N). This method was used, together with other reference methods, to monitor the storage of cod fillets (Gadus morhua) conserved under melting ice. Careful optimisation enabled definition of the best parameters for extracting and separating targeted amines and an internal standard. The study of cod spoilage by sensory analysis and TVB-N assay led to the conclusion that the shelf-life of cod fillet was between 6 and 7 days. Throughout the study, TMA and DMA were specifically quantified by SPME-GC-MS; the first was found to be highly correlated with the values returned by steam distillation assays. Neither TMA-N nor DMA-N were able to successfully characterise the decrease in early freshness, unlike dimethylamine/trimethylamine ratio (DTR), whose evolution is closely related to the results of sensory analysis until the stage where fillets need to be rejected. DTR was proposed as a reliable indicator for the early decrease of freshness until fish rejection. © 2015 Society of Chemical Industry. © 2015 Society of Chemical Industry.

  18. Growth parameter components of adaptive specificity during experimental evolution of the UVR-inducible mutator Pseudomonas cichorii 302959.

    Directory of Open Access Journals (Sweden)

    Michael R Weigand

    Full Text Available BACKGROUND: Mutagenic DNA repair (MDR transiently increases mutation rate through the activation of low-fidelity repair polymerases in response to specific, DNA-damaging environmental stress conditions such as ultraviolet radiation (UVR exposure. These repair polymerases also confer UVR tolerance, intimately linking mutability and survival in bacteria that colone habitats subject to regular UVR exposure. METHODOLOGY/PRINCIPAL FINDINGS: Here, we investigate adaptive specificity in experimental lineages of the highly UVR-mutable epiphytic plant pathogen Pseudomonas cichorii 302959. Relative fitness measurements of isolates and population samples from replicate lineages indicated that adaptive improvements emerged early in all lineages of our evolution experiment and specific increases in relative fitness correlated with distinct improvements in doubling and lag times. Adaptive improvements gained under UVR and non-UVR conditions were acquired preferentially, and differentially contributed to relative fitness under varied growth conditions. CONCLUSIONS: These results support our earlier observations that MDR activation may contribute to gains in relative fitness without impeding normal patterns of adaptive specificity in P. cichorii 302959.

  19. Structural correlation method for model reduction and practical estimation of patient specific parameters illustrated on heart rate regulation

    DEFF Research Database (Denmark)

    Ottesen, Johnny T.; Mehlsen, Jesper; Olufsen, Mette

    2014-01-01

    We consider the inverse and patient specific problem of short term (seconds to minutes) heart rate regulation specified by a system of nonlinear ODEs and corresponding data. We show how a recent method termed the structural correlation method (SCM) can be used for model reduction and for obtaining...

  20. Comparison of aPTT and CT Parameter of the ROTEM Test to Monitor Heparin Anti-Coagulation Effect in ICU Patients: an Observational Study

    Directory of Open Access Journals (Sweden)

    Atabak Najafi

    2015-10-01

    Full Text Available Heparin is frequently used in different clinical settings to reduce the coagulating ability of the blood. Because of probable adverse effects owing to heparin therapy and regarding variability of patients’ responses to heparin, which make it very unreliable, it seems prudent to monitor meticulously its effects on the human body. There are a lot of laboratory tests to watch its effects on the body for example; aPTT and ROTEM are the most widely used tests that are performed today. We aimed to compare the aPTT test results against changes of CT parameter of the ROTEM test due to heparin administration. This study was conducted on 45 critically ill patients who needed to receive heparin according to their clinical status. All patients received 550 to 1500 unit heparin per hour (on average 17.5 unit heparin per kilogram weight. While the patients were under infusion of heparin, two blood samples (5 ml were taken from a newly established cubital vein, just five hours after commencement of heparin therapy. One sample was used for aPTT and the other one for ROTEM. The correlation between aPTT and the changes of CT parameter of the ROTEM with heparin dosage and infusion was the primary outcome. The correlation between heparin therapy and the changes of other parameters like MCF, CFT, and a number of platelets were the secondary outcome of the study. The only significant correlation was between changes of CT and aPTT (P=0.000. The other variables were not correlated. Changes of CT parameter of ROTEM test can be used for monitoring of reduced coagulability during heparin infusion instead of aPTT test.

  1. Multiple parameter synchronous monitor system for human adaptability in altiplano%人体高原适应性多参数同步监测系统

    Institute of Scientific and Technical Information of China (English)

    杨雷; 王磊; 欧燕; 蔡尧钟

    2009-01-01

    To aim at altitude sickness, this multiple parameter synchronous monitor system for human adaptability in alti-plano is excogitated. The change of physiological parameters(SPO2 HR, ECG, pulse wave, breath wave)of human in alti-plano and the environment parameters(altitude, air pressure, temperature, direction, GPS positioning)are monitored via no injury method. The intuitionist estimation is given by the analysis of the multiple parameters using the arithmetic of the adaptability in altiplano. The data can be transmitted by wireless communication module.%针对急性高原反应,研发了相关的人体高原适应性多参数同步监测系统.通过无创的方法来监测人体在高海拔环境下相关生理参数(血氧饱和度、心率、心电、脉搏波、呼吸)的变化,同时监测人体所处外界环境参数(海拔、气压、温度、方向、GPS定位).通过基于无创多参数同步测量系统之上的高原适应性分析算法,对多种参数综合分析,给出人体在高海拔下的高原适应状况的直观判断,通过通讯模块实现数据远距离无线传输.

  2. Study of structure of marine specialist activity in an ergative system on monitoring and managing automatic control parameters of safe navigation process

    Directory of Open Access Journals (Sweden)

    Kholichev S. N.

    2016-12-01

    Full Text Available The study of structures' common features and dynamics of the technical object tuning circuit performing automatic adjustment of safe navigation options has been conducted for the first time in the theory of ergative systems. The research of the structure and process of ergative system functioning including an automatic control system with the option of safe navigation conditions has been fulfilled. The function of signals' selection performing optimal control law reconfiguration of the mentioned system has been given, and some sequence of marine specialist activities allowing solve the problem of navigation safety has been composed. The ergative system retargeted by the ship specialist has a two-tier hierarchy. The first level is an automatic control of the safe navigation parameter, and the second is the level of reconfiguration where the ship specialist changes the parameters of regulation act. The two-level hierarchical representation of the ergative navigation security settings management system makes it possible to introduce the concept of reconfiguration of regulation level as ship specialist activity which is to reduce the uncertainty in the environment in the operation of this layer. Such a reduction can be achieved as a result of exposure to the upper level associated with ideas of the ship specialist on the regulation of safe navigation parameters of the vessel on the lower level – the level of direct control automatic safe navigation option. As a result of studying the activities of the ship specialist in the ergative system on monitoring and managing automatic control parameters of safe navigation process it has been found that the main task of the ship specialist in the operation within the ergative system ensuring the navigation safety is to monitor the input and output of the automatic control system, decisions on the choice of reconfiguration laws regulating signal on the basis of information about deviations and the

  3. Parameter-specific modulation of the mismatch negativity to duration decrement and increment: evidence for asymmetric processes.

    Science.gov (United States)

    Takegata, Rika; Tervaniemi, Mari; Alku, Paavo; Ylinen, Sari; Näätänen, Risto

    2008-07-01

    The mismatch negativity (MMN) component of event-related potentials (ERPs) reflects a change-detection process in the brain. The present study investigated whether stimulus parameters (sound type and duration) exert a differential influence on the MMN for a duration decrement and increment of an equal magnitude. Some asymmetries were reported in the previous studies; yet no systematical study has been conducted. ERPs were recorded from 16 healthy adults presented with repetitive standard sounds interspersed with duration changes (deviant sounds). In separate sequences, stimuli were vowels, music chord, sinusoid, or band-pass filtered white noise. The stimulus durations (standard/deviant) were either 200/120 ms or 400/240 ms for decrements, and vice versa for increments. The MMN for the increments was abolished in the 400/240 ms condition, whereas the MMN for decrements was significant irrespective of the sound duration. The amplitude of the increment MMN paralleled with the spectral complexity of the stimulus sound, whereas that of the decrement MMN was larger for natural sounds than artificial sounds. The observed interactions demonstrated asymmetries in the MMN for duration increment and decrement. The present findings suggest that the effects of stimulus parameters should be taken into account when comparing different studies, especially where clinical populations are involved, with one another.

  4. Investigation of parameters that affect the success rate of microarray-based allele-specific hybridization assays.

    Directory of Open Access Journals (Sweden)

    Lena Poulsen

    Full Text Available BACKGROUND: The development of microarray-based genetic tests for diseases that are caused by known mutations is becoming increasingly important. The key obstacle to developing functional genotyping assays is that such mutations need to be genotyped regardless of their location in genomic regions. These regions include large variations in G+C content, and structural features like hairpins. METHODS/FINDINGS: We describe a rational, stable method for screening and combining assay conditions for the genetic analysis of 42 Phenylketonuria-associated mutations in the phenylalanine hydroxylase gene. The mutations are located in regions with large variations in G+C content (20-75%. Custom-made microarrays with different lengths of complementary probe sequences and spacers were hybridized with pooled PCR products of 12 exons from each of 38 individual patient DNA samples. The arrays were washed with eight buffers with different stringencies in a custom-made microfluidic system. The data were used to assess which parameters play significant roles in assay development. CONCLUSIONS: Several assay development methods found suitable probes and assay conditions for a functional test for all investigated mutation sites. Probe length, probe spacer length, and assay stringency sufficed as variable parameters in the search for a functional multiplex assay. We discuss the optimal assay development methods for several different scenarios.

  5. Site-specific analysis of radiological and physical parameters for cobbly soils at the Gunnison, Colorado, processing site. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-01

    The remedial action at the Gunnison, Colorado, processing site is being performed under the Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978. Under UMTRCA, the US Environmental Protection Agency (EPA) is charged with the responsibility of developing appropriate and applicable standards for the cleanup of radiologically contaminated land and buildings at 24 designated sites, including the Gunnison, Colorado, inactive processing site. Section 108 of Public Law 95-604 states that the US Department of Energy (DOE) shall ``select and perform remedial actions at the designated processing sites and disposal sites in accordance with the general standards`` prescribed by the EPA. Regulations governing the required remedial action at inactive uranium processing sites were promulgated by the EPA in 1983 and are contained in 40 CFR Part 192 (1993), Health and Environmental Protection Standards for Uranium and Thorium Mill Tailings. This document describes the radiological and physical parameters for the remedial action of the soil.

  6. Site-specific analysis of radiological and physical parameters for cobbly soils at the Gunnison, Colorado, processing site. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-01

    The remedial action at the Gunnison, Colorado, processing site is being performed under the Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978. Under UMTRCA, the US Environmental Protection Agency (EPA) is charged with the responsibility of developing appropriate and applicable standards for the cleanup of radiologically contaminated land and buildings at 24 designated sites, including the Gunnison, Colorado, inactive processing site. Section 108 of Public Law 95-604 states that the US Department of Energy (DOE) shall ``select and perform remedial actions at the designated processing sites and disposal sites in accordance with the general standards`` prescribed by the EPA. Regulations governing the required remedial action at inactive uranium processing sites were promulgated by the EPA in 1983 and are contained in 40 CFR Part 192 (1993), Health and Environmental Protection Standards for Uranium and Thorium Mill Tailings. This document describes the radiological and physical parameters for the remedial action of the soil.

  7. Long-Term Transit Timing Monitoring and Refined Light Curve Parameters of HAT-P-13b

    CERN Document Server

    Fulton, Benjamin J; Winn, Joshua N; Holman, Matthew J; Pál, András; Gazak, J Zachary

    2011-01-01

    We present 10 new transit light curves of the transiting hot Jupiter HAT-P-13b, obtained during two observational seasons by three different telescopes. When combined with 12 previously published light curves, we have a sample consisting of 22 transit light curves, spanning 1,041 days across 4 observational seasons. We use this sample to examine the recently observed large-amplitude transit timing variations (P\\'al et al. 2011), and give refined system parameters. We find that the transit times are consistent with a linear ephemeris, with the exception of a single transit time, from UT 2009 Nov 5, for which the measured mid transit time significantly deviates from our linear ephemeris. The nature of this deviation is not clear, and the rest of the data does not show any significant transit timing variation.

  8. A method to rapidly determine the sintering process parameters of powder metallurgy by real-time resistivity monitoring

    Science.gov (United States)

    Xiao, Zhen; Liu, Huanchao; Geng, Haoran; Leng, Jinfeng

    2016-10-01

    A new method, which is called the resistivity method, is applied in this paper to explore the optimum sintering parameters of powder metallurgy (PM) since general methods are always labor-intensive and time-consuming. This method can probe the resistivity of the powder metallurgy samples in real-time during the sintering process, to quickly estimate the change of the relative density, which consequently determine the properties of the sintered item. As an example, in this paper, copper/tungsten carbide (Cu/WC) composites and pure aluminum (Al) powder compacts are experimentally considered. As a result, for the Cu/WC composites, the highest value of relative density appeared at the holding time of 50 min where the sample has the lowest resistivity. For the Al compacts, the optimum sintering temperature is 450 °C, and the longer the holding time the better.

  9. Development of catechol 2,3-dioxygenase-specific primers for monitoring bioremediation by competitive quantitative PCR

    Energy Technology Data Exchange (ETDEWEB)

    Mesarch, M.B.; Nakatsu, C.H.; Nies, L.

    2000-02-01

    Benzene, toluene, xylenes, phenol, naphthalene, and biphenyl are among a group of compounds that have at least one reported pathway for biodegradation involving catechol 2,3-dioxygenase enzymes. Thus, detection of the corresponding catechol 2,3-dioxygenase genes can serve as a basis for identifying and quantifying bacteria that have these catabolic abilities. Primes that can successfully amplify a 238-bp catechol 2,3-dioxygenase gene fragment from eight different bacteria are described. The identities of the amplicons were confirmed by hybridization with a 238-bp catechol 2,3-dioxygenase probe. The detection limit was 10{sup 2} to 10{sup 3} gene copies, which was lowered to 10{sup 0} to 10{sup 1} gene copies of hybridization. Using the dioxygenase-specific primers, an increase in catechol 2,3-dioxygenase genes was detected in petroleum-amended soils. The dioxygenase genes were enumerated by competitive quantitative PCR and a 163-bp competitor that was amplified using the same primers. Target and competitor sequences had identical amplification kinetics. Potential PCR inhibitors that could coextract with DNA, nonamplifying DNA, soil factors (humics), and soil pollutants (toluene) did not impact enumeration. Therefore, this technique can be used to accurately and reproducibly quantify catechol 2,3-dioxygenase genes in complex environments such as petroleum-contaminated soil. Direct, non-cultivation-based molecular techniques for detecting and enumerating microbial pollutant-biodegrading genes in environmental samples are powerful tools for monitoring bioremediation and developing field evidence in support of natural attenuation.

  10. The integrity of lichen cell membrane as a suitable parameter for monitoring biological effects of acute nitrogen pollution.

    Science.gov (United States)

    Munzi, S; Pisani, T; Loppi, S

    2009-10-01

    This study aimed at testing the suitability of cell membrane integrity in the lichen Evernia prunastri (L.) Ach. as sensitive indicator of nitrogen (N) stress, to set up a rapid and effective method for monitoring biological effects of acute N pollution. Lichen samples were incubated in solutions of potassium nitrate, ammonium nitrate and ammonium sulphate at different concentrations, and cell membrane damage, expressed in terms of increased electrolyte leakage, was measured after 0, 24, 48 and 96 h. Cell membrane damage was observed in E. prunastri in the presence of high or very high N concentrations, irrespective of the compound supplied. Since the mycobiont represents the large majority of a lichen biomass, it is reasonable to assume that ion leakage mainly occurred from fungal cells. Although in biomonitoring studies the photobiont is usually regarded as the most sensitive partner of the lichen symbiosis, our findings suggest that the mycobiont is most affected in the case of N-excess, and that this feature can be used as suitable indicator of acute N stress episodes.

  11. The potential of computer vision, optical backscattering parameters and artificial neural network modelling in monitoring the shrinkage of sweet potato (Ipomoea batatas L.) during drying.

    Science.gov (United States)

    Onwude, Daniel I; Hashim, Norhashila; Abdan, Khalina; Janius, Rimfiel; Chen, Guangnan

    2017-07-30

    Drying is a method used to preserve agricultural crops. During the drying of products with high moisture content, structural changes in shape, volume, area, density and porosity occur. These changes could affect the final quality of dried product and also the effective design of drying equipment. Therefore, this study investigated a novel approach in monitoring and predicting the shrinkage of sweet potato during drying. Drying experiments were conducted at temperatures of 50-70 °C and samples thicknesses of 2-6 mm. The volume and surface area obtained from camera vision, and the perimeter and illuminated area from backscattered optical images were analysed and used to evaluate the shrinkage of sweet potato during drying. The relationship between dimensionless moisture content and shrinkage of sweet potato in terms of volume, surface area, perimeter and illuminated area was found to be linearly correlated. The results also demonstrated that the shrinkage of sweet potato based on computer vision and backscattered optical parameters is affected by the product thickness, drying temperature and drying time. A multilayer perceptron (MLP) artificial neural network with input layer containing three cells, two hidden layers (18 neurons), and five cells for output layer, was used to develop a model that can monitor, control and predict the shrinkage parameters and moisture content of sweet potato slices under different drying conditions. The developed ANN model satisfactorily predicted the shrinkage and dimensionless moisture content of sweet potato with correlation coefficient greater than 0.95. Combined computer vision, laser light backscattering imaging and artificial neural network can be used as a non-destructive, rapid and easily adaptable technique for in-line monitoring, predicting and controlling the shrinkage and moisture changes of food and agricultural crops during drying. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  12. Impact of tissue specific parameters on the predition of the biological effectiveness for treatment planning in ion beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Gruen, Rebecca Antonia

    2014-06-03

    Treatment planning in ion beam therapy requires a reliable estimation of the relative biological effectiveness (RBE) of the irradiated tissue. For the pilot project at GSI Helmholtzzentrum fuer Schwerionenforschung GmbH and at other European ion beam therapy centers RBE prediction is based on a biophysical model, the Local Effect Model (LEM). The model version in use, LEM I, is optimized to give a reliable estimation of RBE in the target volume for carbon ion irradiation. However, systematic deviations are observed for the entrance channel of carbon ions and in general for lighter ions. Thus, the LEM has been continuously developed to improve accuracy. The recent version LEM IV has proven to better describe in-vitro cell experiments. Thus, for the clinical application of LEM IV it is of interest to analyze potential differences compared to LEM I under treatment-like conditions. The systematic analysis presented in this work is aiming at the comparison of RBE-weighted doses resulting from different approaches and model versions for protons and carbon ions. This will facilitate the assessment of consequences for clinical application and the interpretation of clinical results from different institutions. In the course of this thesis it has been shown that the RBE-weighted doses predicted on the basis of LEM IV for typical situations representing chordoma treatments differ on average by less than 10 % to those based on LEM I and thus also allow a consistent interpretation of the clinical results. At Japanese ion beam therapy centers the RBE is estimated using their clinical experience from neutron therapy in combination with in-vitro measurements for carbon ions (HIMAC approach). The methods presented in this work allow direct comparison of the HIMAC approach and the LEM and thus of the clinical results obtained at Japanese and European ion beam therapy centers. Furthermore, the sensitivity of the RBE on the model parameters was evaluated. Among all parameters the

  13. Performance-based quality specifications: the relationship between process critical control parameters, critical quality attributes, and clinical performance.

    Science.gov (United States)

    Short, Steven M; Cogdill, Robert P; Drennen, James K; Anderson, Carl A

    2011-04-01

    The quality of pharmaceutical products is currently evaluated through a series of tests that do not explicitly communicate the clinical consequences of product variability. A previously published risk simulation platform was used to generate quantitative estimates of inefficacy and toxicity for 288 uniform lots of extended-release theophylline tablets displaying various levels of content uniformity and dissolution variability. These data were used to evaluate the univariate specifications utilized in the United States Pharmacopeia (USP) and . Simulation revealed that the specifications are too lenient for content uniformity, both in terms of inefficacy and toxicity, whereas the criteria for dissolution testing are too strict for inefficacy and inaccurate for toxicity. The USP tests also failed to pinpoint the clinical interaction between content uniformity and dissolution variability. Additionally, the simulation platform was used to define the underlying relationship between product quality attributes and clinical performance. Here, content uniformity and Weibull dissolution time constants were used as inputs to the design spaces, which were conditioned on quantitative estimates of inefficacy and toxicity. This methodology enhances the information content of the design space by omitting quality surrogates (e.g., dissolution, moisture content) that are utilized in current design space practices.

  14. Lipase-catalyzed Synthesis of Caffeic Acid Phenethyl Ester in Ionic Liquids:Effect of Specific Ions and Reaction Parameters

    Institute of Scientific and Technical Information of China (English)

    王俊; 李晶; 张磊霞; 顾双双; 吴福安

    2013-01-01

    Caffeic acid phenethyl ester (CAPE) is a rare, naturally occurring phenolic food additive. This work systematically reported fundamental data on conversion of caffeic acid (CA), yield of CAPE, and reactive selectiv-ity during the lipase-catalyzed esterification process of CA and phenylethanol (PE) in ionic liquids (ILs). Sixteen ILs were selected as the reaction media, and the relative lipase-catalyzed synthesis properties of CAPE were meas-ured in an effort to enhance the yield of CAPE with high selectivity. The results indicated that ILs containing weakly coordinating anions and cations with adequate alkyl chain length improved the synthesis of CAPE. [Emim][Tf2N] was selected as the optimal reaction media. The optimal parameters were as follows by response surface methodology (RSM):reaction temperature, 84.0 °C;mass ratio of Novozym 435 to CA, 14︰1;and molar ratio of PE to CA, 16︰1. The highest reactive selectivity of CAPE catalyzed by Novozym 435 in [Emim][Tf2N] reached 64.55%(CA conversion 98.76%and CAPE yield 63.75%, respectively). Thus, lipase-catalyzed esterifica-tion in ILs is a promising method suitable for CAPE production.

  15. An Integrated Geomechanical Investigation, Multi-Parameter Monitoring and Analyses of Babadağ-Gündoğdu Creep-like Landslide

    Science.gov (United States)

    Kumsar, Halil; Aydan, Ömer; Tano, Hisataka; Çelik, Sefer Beran; Ulusay, Reşat

    2016-06-01

    A creep-like landslide in the Gündoğdu district of Babadağ town in Denizli (Turkey), where about 2000 people lived within the damaged houses, has been moving with a velocity of 4-14 cm/year since 1940s. Field observations and monitoring together with geomechanical laboratory tests were carried out to investigate the causative factors of the landslide. These studies were conducted as a part of an international research project performed by Turkish and Japanese scientists since 2000. Long-term monitoring stations established involved measurements of meteorological parameters, displacements, acoustic emission counts, variations in groundwater table, borehole strain measurement, in situ permeability and infiltration characteristics of the slope forming materials, and vibrations induced by weaving machines during their operation. Geomechanical properties of the sandstone and marl, which form the unstable slope, were determined from laboratory tests. In addition to the use of conventional 2-D equilibrium method of analyses, a new approach for modelling the long-term creep-like behaviour of the landslide body, based on discrete finite element method, was also proposed and used to analyse the landslide. It was found that the sliding mass has been involving several zones of weakness (interface) between the sandstone and marl layers through in situ monitoring. The monitoring data of pipe strain, groundwater level fluctuation and rainfall, and AE data showed that slope movement accelerated during and after rainy seasons. It was obtained that the proposed numerical method based on discrete finite element method (DFEM), which considers the softening and hardening of stiffness of the weakness zone as a function of rainfall and, is capable of simulating creep-like behaviour of the landslide. Disaster and Emergency Management Authority of Turkey also considered the results of this research and the landslide area was designated as a Natural Disaster Area and the people living in

  16. Estimation of left ventricular blood flow parameters: clinical application of patient-specific CFD simulations from 4D echocardiography

    Science.gov (United States)

    Larsson, David; Spühler, Jeannette H.; Günyeli, Elif; Weinkauf, Tino; Hoffman, Johan; Colarieti-Tosti, Massimiliano; Winter, Reidar; Larsson, Matilda

    2017-03-01

    Echocardiography is the most commonly used image modality in cardiology, assessing several aspects of cardiac viability. The importance of cardiac hemodynamics and 4D blood flow motion has recently been highlighted, however such assessment is still difficult using routine echo-imaging. Instead, combining imaging with computational fluid dynamics (CFD)-simulations has proven valuable, but only a few models have been applied clinically. In the following, patient-specific CFD-simulations from transthoracic dobutamin stress echocardiography have been used to analyze the left ventricular 4D blood flow in three subjects: two with normal and one with reduced left ventricular function. At each stress level, 4D-images were acquired using a GE Vivid E9 (4VD, 1.7MHz/3.3MHz) and velocity fields simulated using a presented pathway involving endocardial segmentation, valve position identification, and solution of the incompressible Navier-Stokes equation. Flow components defined as direct flow, delayed ejection flow, retained inflow, and residual volume were calculated by particle tracing using 4th-order Runge-Kutta integration. Additionally, systolic and diastolic average velocity fields were generated. Results indicated no major changes in average velocity fields for any of the subjects. For the two subjects with normal left ventricular function, increased direct flow, decreased delayed ejection flow, constant retained inflow, and a considerable drop in residual volume was seen at increasing stress. Contrary, for the subject with reduced left ventricular function, the delayed ejection flow increased whilst the retained inflow decreased at increasing stress levels. This feasibility study represents one of the first clinical applications of an echo-based patient-specific CFD-model at elevated stress levels, and highlights the potential of using echo-based models to capture highly transient flow events, as well as the ability of using simulation tools to study clinically complex

  17. Orbital and Superorbital Monitoring of the Be/X-ray binary A0538-66: constraints on the system parameters

    Science.gov (United States)

    Rajoelimanana, A. F.; Charles, P. A.; Meintjes, P. J.; Townsend, L. J.; Schurch, M. P. E.; Udalski, A.

    2016-10-01

    We combine the decade long photometry of the Be/X-ray binary system A0538-66 provided by the MACHO and OGLE IV projects with high resolution SALT spectroscopy to provide detailed constraints on the orbital parameters and system properties. The ˜420d superorbital modulation is present throughout, but has reduced in amplitude in recent years. The well-defined 16.6409d orbital outbursts, which were a strong function of superorbital phase in the MACHO data (not occurring at all at superorbital maximum), are present throughout the OGLE IV coverage. However, their amplitude reduces during superorbital maximum. We have refined the orbital period and ephemeris of the optical outburst based on ˜ 25 yrs light curves to HJD = 2455674.48±0.03 + n*16.6409±0.0003d. Our SALT spectra reveal a B1 III star with vsin i of 285 kms-1 from which we have derived an orbital radial velocity curve which confirms the high eccentricity of e = 0.72±0.14. Furthermore, the mass function indicates that, unless the neutron star far exceeds the canonical 1.44 M⊙, the donor must be significantly undermassive for its spectral type. We discuss the implications of the geometry and our derived orbital solution on the observed behaviour of the system.

  18. Orbital and superorbital monitoring of the Be/X-ray binary A0538-66: constraints on the system parameters

    Science.gov (United States)

    Rajoelimanana, A. F.; Charles, P. A.; Meintjes, P. J.; Townsend, L. J.; Schurch, M. P. E.; Udalski, A.

    2017-02-01

    We combine the decade-long photometry of the Be/X-ray binary system A0538-66 provided by the Massive astrophysical compact halo object (MACHO) and optical gravitational lensing experiment (OGLE) IV projects with high-resolution Southern African Large Telescope (SALT) spectroscopy to provide detailed constraints on the orbital parameters and system properties. The ˜420 d superorbital modulation is present throughout, but has reduced in amplitude in recent years. The well-defined 16.6409 d orbital outbursts, which were a strong function of superorbital phase in the MACHO data (not occurring at all at superorbital maximum), are present throughout the OGLE IV coverage. However, their amplitude reduces during superorbital maximum. We have refined the orbital period and ephemeris of the optical outburst based on ˜25 yr light curves to HJD = 2455674.48 ± 0.03 + n*16.6409 ± 0.0003d. Our SALT spectra reveal a B1 III star with vsin i of 285 kms-1 from which we have derived an orbital radial velocity curve which confirms the high eccentricity of e = 0.72 ± 0.14. Furthermore, the mass function indicates that, unless the neutron star far exceeds the canonical 1.44 M⊙, the donor must be significantly undermassive for its spectral type. We discuss the implications of the geometry and our derived orbital solution on the observed behaviour of the system.

  19. Continuous monitoring of biophysical Eucalyptus sp. parameters using interferometric synthetic aperture radar data in P and X bands

    Science.gov (United States)

    Gama, Fábio Furlan; dos Santos, João Roberto; Mura, José Claudio

    2016-04-01

    This work aims to verify the applicability of models obtained using interferometric synthetic aperture radar (SAR) data for estimation of biophysical Eucalyptus saligna parameters [diameter of breast height (DBH), total height and volume], as a method of continuous forest inventory. In order to obtain different digital elevation models, and the interferometric height (Hint) to retrieve the tree heights, SAR surveying was carried out by an airborne interferometric SAR in two frequencies X and P bands. The study area, located in the Brazilian southeast region (S 22°53‧22″/W 45°26‧16″ and S 22°53‧22″/W 45°26‧16″), comprises 128.64 hectares of Eucalyptus saligna stands. The methodological procedures encompassed: forest inventory, topographic surveying, radar mapping, radar processing, and multivariable regression techniques to build Eucalyptus volume, DBH, and height models. The statistical regression pointed out Hint and interferometric coherence as the most important variables for the total height and DBH estimation; for the volume model, however, only the Hint variable was selected. The performance of the biophysical models from the second campaign, two years later (2006), were consistent and its results are very promising for updating annual inventories needed for managing Eucalyptus plantations.

  20. Orbital and Superorbital Monitoring of the Be/X-ray binary A0538-66: constraints on the system parameters

    CERN Document Server

    Rajoelimanana, A F; Meintjes, P J; Townsend, L J; Schurch, M P E; Udalski, A

    2016-01-01

    We combine the decade long photometry of the Be/X-ray binary system A0538-66 provided by the MACHO and OGLE IV projects with high resolution SALT spectroscopy to provide detailed constraints on the orbital parameters and system properties. The ~420d superorbital modulation is present throughout, but has reduced in amplitude in recent years. The well-defined 16.6409d orbital outbursts, which were a strong function of superorbital phase in the MACHO data (not occurring at all at superorbital maximum), are present throughout the OGLE IV coverage. However, their amplitude reduces during superorbital maximum. We have refined the orbital period and ephemeris of the optical outburst based on ~25 yrs light curves to HJD = 2455674.48 +/- 0.03 + n*16.6409 +/- 0.0003d. Our SALT spectra reveal a B1 III star with vsini of 285 km/s from which we have derived an orbital radial velocity curve which confirms the high eccentricity of e = 0.72 +/- 0.14. Furthermore, the mass function indicates that, unless the neutron star far ...

  1. Visual information transfer. Part 1: Assessment of specific information needs. Part 2: Parameters of appropriate instrument scanning behavior

    Science.gov (United States)

    Comstock, J. R., Jr.; Kirby, R. H.; Coates, G. D.

    1985-01-01

    The present study explored eye scan behavior as a function of level of subject training. Oculometric (eye scan) measures were recorded from each of ten subjects during training trials on a CRT based flight simulation task. The task developed for the study incorporated subtasks representative of specific activities performed by pilots, but which could be performed at asymptotic levels within relatively short periods of training. Changes in eye scan behavior were examined as initially untrained subjects developed skill in the task. Eye scan predictors of performance on the task were found. Examination of eye scan in proximity to selected task events revealed differences in the distribution of looks at the instruments as a function of level of training.

  2. Development of Site-Specific Soil Design Basis Earthquake (DBE) Parameters for the Integrated Waste Treatment Unit (IWTU)

    Energy Technology Data Exchange (ETDEWEB)

    Payne, Suzette

    2008-08-01

    Horizontal and vertical PC 3 (2,500 yr) Soil Design Basis Earthquake (DBE) 5% damped spectra, corresponding time histories, and strain-compatible soil properties were developed for the Integrated Waste Treatment Unit (IWTU). The IWTU is located at the Idaho Nuclear Technology and Engineering Center (INTEC) at the Idaho National Laboratory (INL). Mean and 84th percentile horizontal DBE spectra derived from site-specific site response analyses were evaluated for the IWTU. The horizontal and vertical PC 3 (2,500 yr) Soil DBE 5% damped spectra at the 84th percentile were selected for Soil Structure Interaction (SSI) analyses at IWTU. The site response analyses were performed consistent with applicable Department of Energy (DOE) Standards, recommended guidance of the Nuclear Regulatory Commission (NRC), American Society of Civil Engineers (ASCE) Standards, and recommendations of the Blue Ribbon Panel (BRP) and Defense Nuclear Facilities Safety Board (DNFSB).

  3. Optical parameter measurement of highly diffusive tissue body phantoms with specifically designed sample holder for photo diagnostic and PDT applications

    Science.gov (United States)

    Rehman, A.; Rehman, K.; Anwar, S.; Firdous, S.; Nawaz, M.

    2015-12-01

    Knowledge of optical properties (absorption coefficients, scattering Coefficients, and anisotropy) is necessary for understanding light tissue interactions. Optical parameters define the behavior of light in the tissues. Intralipid and Indian ink are well-established tissue body phantoms. Quantitative characterization of biological tissues in terms of optical properties is achieved with integrating sphere. However, samples having significantly higher scattering and absorption coefficients such as malignant tissues potentially reduce the signal to noise ratio (SNR) and accuracy of integrating sphere. We have measured the diffuse reflection and transmission of these phantoms by placing them in integrating sphere at 632.8 nm and then applied IAD method to determine the optical properties tissue phantoms composed of Indian ink (1.0%) and Intralipid (20%). We have fabricated a special sample holder with thin microscopic cover slips which can be used to measure signal from highly concentrated intralipid and Indian ink solutions. Experiments conducted with various phantoms reveal significant improvement of SNR for a wide range of optical properties. This approach opens up a field for potential applications in measurement of optical properties of highly diffusive biological tissues. For 20% intralipid μa =0.112+/-0.046 cm-1 and μs =392.299+/-10.090 cm-1 at 632.8 nm and for 1.0% Indian ink μa =9.808+/-0.490 cm-1 and μs =1.258+/-0.063 cm-1 at same wavelength. System shows good repeatability and reproducibility within 4.9% error. Work may have important biomedical applications in photo-diagnosis and Photodynamic therapy.

  4. Simultaneous monitoring of static and dynamic intracranial pressure parameters from two separate sensors in patients with cerebral bleeds: comparison of findings

    Directory of Open Access Journals (Sweden)

    Eide Per

    2012-09-01

    Full Text Available Abstract Background We recently reported that in an experimental setting the zero pressure level of solid intracranial pressure (ICP sensors can be altered by electrostatics discharges. Changes in the zero pressure level would alter the ICP level (mean ICP; whether spontaneous changes in mean ICP happen in clinical settings is not known. This can be addressed by comparing the ICP parameters level and waveform of simultaneous ICP signals. To this end, we retrieved our recordings in patients with cerebral bleeds wherein the ICP had been recorded simultaneously from two different sensors. Materials and Methods: During a time period of 10 years, 17 patients with cerebral bleeds were monitored with two ICP sensors simultaneously; sensor 1 was always a solid sensor while Sensor 2 was a solid -, a fluid - or an air-pouch sensor. The simultaneous signals were analyzed with automatic identification of the cardiac induced ICP waves. The output was determined in consecutive 6-s time windows, both with regard to the static parameter mean ICP and the dynamic parameters (mean wave amplitude, MWA, and mean wave rise time, MWRT. Differences in mean ICP, MWA and MWRT between the two sensors were determined. Transfer functions between the sensors were determined to evaluate how sensors reproduce the ICP waveform. Results Comparing findings in two solid sensors disclosed major differences in mean ICP in 2 of 5 patients (40%, despite marginal differences in MWA, MWRT, and linear phase magnitude and phase. Qualitative assessment of trend plots of mean ICP and MWA revealed shifts and drifts of mean ICP in the clinical setting. The transfer function analysis comparing the solid sensor with either the fluid or air-pouch sensors revealed more variable transfer function magnitude and greater differences in the ICP waveform derived indices. Conclusions Simultaneous monitoring of ICP using two solid sensors may show marked differences in static ICP but close to identity

  5. VERONA V6.22 – An enhanced reactor analysis tool applied for continuous core parameter monitoring at Paks NPP

    Energy Technology Data Exchange (ETDEWEB)

    Végh, J., E-mail: janos.vegh@ec.europa.eu [Institute for Energy and Transport of the Joint Research Centre of the European Commission, Postbus 2, NL-1755 ZG Petten (Netherlands); Pós, I., E-mail: pos@npp.hu [Paks Nuclear Power Plant Ltd., H-7031 Paks, P.O. Box 71 (Hungary); Horváth, Cs., E-mail: csaba.horvath@energia.mta.hu [Centre for Energy Research, Hungarian Academy of Sciences, H-1525 Budapest 114, P.O. Box 49 (Hungary); Kálya, Z., E-mail: kalyaz@npp.hu [Paks Nuclear Power Plant Ltd., H-7031 Paks, P.O. Box 71 (Hungary); Parkó, T., E-mail: parkot@npp.hu [Paks Nuclear Power Plant Ltd., H-7031 Paks, P.O. Box 71 (Hungary); Ignits, M., E-mail: ignits@npp.hu [Paks Nuclear Power Plant Ltd., H-7031 Paks, P.O. Box 71 (Hungary)

    2015-10-15

    Between 2003 and 2007 the Hungarian Paks NPP performed a large modernization project to upgrade its VERONA core monitoring system. The modernization work resulted in a state-of-the-art system that was able to support the reactor thermal power increase to 108% by more accurate and more frequent core analysis. Details of the new system are given in Végh et al. (2008), the most important improvements were as follows: complete replacement of the hardware and the local area network; application of a new operating system and porting a large fraction of the original application software to the new environment; implementation of a new human-system interface; and last but not least, introduction of new reactor physics calculations. Basic novelty of the modernized core analysis was the introduction of an on-line core-follow module based on the standard Paks NPP core design code HELIOS/C-PORCA. New calculations also provided much finer spatial resolution, both in terms of axial node numbers and within the fuel assemblies. The new system was able to calculate the fuel applied during the first phase of power increase accurately, but it was not tailored to determine the effects of burnable absorbers as gadolinium. However, in the second phase of the power increase process the application of fuel assemblies containing three fuel rods with gadolinium content was intended (in order to optimize fuel economy), therefore off-line and on-line VERONA reactor physics models had to be further modified, to be able to handle the new fuel according to the accuracy requirements. In the present paper first a brief overview of the system version (V6.0) commissioned after the first modernization step is outlined; then details of the modified off-line and on-line reactor physics calculations are described. Validation results for new modules are treated extensively, in order to illustrate the extent and complexity of the V&V procedure associated with the development and licensing of the new

  6. Parameter Identification of an Ultrafiltration Model for Organics Removal in a Full-Scale Wastewater Reclamation Plant with Sparse and Incomplete Monitoring Data.

    Science.gov (United States)

    Sun, Fu; Zeng, Siyu; Huang, Yunqing; He, Miao

    2016-01-01

    Ultrafiltration (UF) has become one of the dominant treatment processes for wastewater reclamation in China. Modeling is an effective instrument to understand and optimize UF systems. To this end, a previously developed UF model for organics removal was applied to the UF process in a typical, full-scale wastewater reclamation plant (WRP) in China. However, the sparse and incomplete field monitoring data from the studied WRP made the traditional model analysis approaches hardly work in this case. Therefore, two strategies, namely Strategy 1 and Strategy 2, were proposed, following a regional sensitivity analysis approach, for model parameter identification. Strategy 1 aimed to identify the model parameters and the missing model input, i.e. sampling times, simultaneously, while Strategy 2 tried to separate these two processes to reduce the dimension of the identification problem through an iteration procedure. With these two strategies, the model performed well in the Qinghe WRP with the absolute relative errors between the simulated and observed total organic carbon (TOC) generally below 10%. The four model parameters were all sensitive and identifiable, and even the sampling times could be roughly identified. Given the incomplete model input, these results were encouraging and added to the trustworthiness of model when it was applied to the Qinghe WRP.

  7. Toxicity of ionic liquids: eco(cyto)activity as complicated, but unavoidable parameter for task-specific optimization.

    Science.gov (United States)

    Egorova, Ksenia S; Ananikov, Valentine P

    2014-02-01

    Rapid progress in the field of ionic liquids in recent decades led to the development of many outstanding energy-conversion processes, catalytic systems, synthetic procedures, and important practical applications. Task-specific optimization emerged as a sharpening stone for the fine-tuning of structure of ionic liquids, which resulted in unprecedented efficiency at the molecular level. Ionic-liquid systems showed promising opportunities in the development of green and sustainable technologies; however, the chemical nature of ionic liquids is not intrinsically green. Many ionic liquids were found to be toxic or even highly toxic towards cells and living organisms. In this Review, we show that biological activity and cytotoxicity of ionic liquids dramatically depend on the nature of a biological system. An ionic liquid may be not toxic for particular cells or organisms, but may demonstrate high toxicity towards another target present in the environment. Thus, a careful selection of biological activity data is a must for the correct assessment of chemical technologies involving ionic liquids. In addition to the direct biological activity (immediate response), several indirect effects and aftereffects are of primary importance. The following principal factors were revealed to modulate toxicity of ionic liquids: i) length of an alkyl chain in the cation; ii) degree of functionalization in the side chain of the cation; iii) anion nature; iv) cation nature; and v) mutual influence of anion and cation.

  8. Molecular dynamics simulations of the dynamic and energetic properties of alkali and halide ions using water-model-specific ion parameters.

    Science.gov (United States)

    Joung, In Suk; Cheatham, Thomas E

    2009-10-01

    The dynamic and energetic properties of the alkali and halide ions were calculated using molecular dynamics (MD) and free energy simulations with various different water and ion force fields including our recently developed water-model-specific ion parameters. The properties calculated were activity coefficients, diffusion coefficients, residence times of atomic pairs, association constants, and solubility. Through calculation of these properties, we can assess the validity and range of applicability of the simple pair potential models and better understand their limitations. Due to extreme computational demands, the activity coefficients were only calculated for a subset of the models. The results qualitatively agree with experiment. Calculated diffusion coefficients and residence times between cation-anion, water-cation, and water-anion showed differences depending on the choice of water and ion force field used. The calculated solubilities of the alkali-halide salts were generally lower than the true solubility of the salts. However, for both the TIP4P(EW) and SPC/E water-model-specific ion parameters, solubility was reasonably well-reproduced. Finally, the correlations among the various properties led to the following conclusions: (1) The reliability of the ion force fields is significantly affected by the specific choice of water model. (2) Ion-ion interactions are very important to accurately simulate the properties, especially solubility. (3) The SPC/E and TIP4P(EW) water-model-specific ion force fields are preferred for simulation in high salt environments compared to the other ion force fields.

  9. Design of monitoring system for physiological parameters of a crew%乘员生理参数监测系统设计

    Institute of Scientific and Technical Information of China (English)

    万红; 王延琦; 考希宾; 闫金海; 罗思源

    2015-01-01

    Objective To design a monitoring system of the state of life for a crew in order to ensure their life safety. Methods A wearable physiological parameter monitoring technology was used, and the fabric electrode and temperature sensors were embedded in the vest.The thress-lead electrode was used to extract ECG and respiration signal,temperature signals were collected with a thermistor of negative temperature parameters.Blood pressure and blood oxygen saturation were detected by a finger cuff type of blood oxygen sensors.The volume pulse wave velocity method was used to extract blood pressure signals,and the photoelectric measurement method was used to extract blood oxygen saturation signals.The state of life was evaluated by calculation of the times of respiration and divided into 4 states.Results and Conclusion The system is capable of low load dynamic monitoring of physiological parameters of a crew and evaluation of their state of life, contributing much to self-aid and buddy aid among the crew.%目的:为掌握乘员的生命状态,提供生命保障,设计乘员生命状态监测系统。方法采用穿戴式生理参数监测技术,在背心中嵌入织物电极和温度传感器,用三导联电极采集心电和呼吸信号,用负温度系数的热敏电阻采集体温信号;血压、血氧饱和度共用指套式血氧传感器,用容积脉搏波速法采集血压信号,用光电测量法采集血氧饱和度信号,在战伤时即插即用;用呼吸次数将生命状态评估为4种状态,结果传输至车长终端。结果及结论系统实现了对乘员生理参数的低负荷动态监测及乘员生命状态的评估监测,对乘员开展自救互救将起到重要的支持作用。

  10. EFFICACY OF TASK SPECIFIC STEP-UP EXERCISES ON THE GAIT PARAMETERS OF CHRONIC HEMIPARETIC STROKE INDIVIDUALS

    Directory of Open Access Journals (Sweden)

    Manju Vats

    2013-10-01

    Full Text Available Background:It has been contended that weight asymmetry and impaired balance function may be a consequenceof a learned disuse of the paretic leg chronic hemiparetic stroke individuals.Purpose of the study:To determinewhether the task- specific step up exercises would lead to greater improvements of spatio-temporal gaitparameters of chronic hemiparetic stroke individuals.Methods:30 individuals, who had a stroke for morethan 6 months and able to ambulate independently, were included in the study. Participants were randomlyassigned to the step up exercises group (n = 15 or control group (n =15. Participants were evaluated at baselineand after 4 weeks of intervention for gait measures like step length- affected/unaffected sides; stride length-affected/unaffected sides; natural velocity; maximum velocity and cadence. The experimental group performedforward, lateral and backward step up exercises, and the control group performed Conventional balance andgait training for30 min./session; five days/week.Results:Both groups improved significantly in all outcomemeasures .However, step up group demonstrated a significantly greater improvement in all gait measurescompared with the control group (almost 2 fold of change was noticed in all gait measures of step up group ascompared with control group.Conclusions:The results of this study convince us that a compelled weight-bearing protocol through the step up training program is one such approach designed to facilitate enhancedmovement in the involved lower limb reducing the impact of learned disuse.Brief Summary and PotentialImplications:The step up exercises are accessible to patients and can be performed in the home, especiallywhen patients are not able to come for regular outpatient therapy.

  11. mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action*

    Science.gov (United States)

    Soliman, Ghada A.; Acosta-Jaquez, Hugo A.; Dunlop, Elaine A.; Ekim, Bilgen; Maj, Nicole E.; Tee, Andrew R.; Fingar, Diane C.

    2010-01-01

    The mammalian target of rapamycin (mTOR) Ser/Thr kinase signals in at least two multiprotein complexes distinguished by their different partners and sensitivities to rapamycin. Acute rapamycin inhibits signaling by mTOR complex 1 (mTORC1) but not mTOR complex 2 (mTORC2), which both promote cell growth, proliferation, and survival. Although mTORC2 regulation remains poorly defined, diverse cellular mitogens activate mTORC1 signaling in a manner that requires sufficient levels of amino acids and cellular energy. Before the identification of distinct mTOR complexes, mTOR was reported to autophosphorylate on Ser-2481 in vivo in a rapamycin- and amino acid-insensitive manner. These results suggested that modulation of mTOR intrinsic catalytic activity does not universally underlie mTOR regulation. Here we re-examine the regulation of mTOR Ser-2481 autophosphorylation (Ser(P)-2481) in vivo by studying mTORC-specific Ser(P)-2481 in mTORC1 and mTORC2, with a primary focus on mTORC1. In contrast to previous work, we find that acute rapamycin and amino acid withdrawal markedly attenuate mTORC1-associated mTOR Ser(P)-2481 in cycling cells. Although insulin stimulates both mTORC1- and mTORC2-associated mTOR Ser(P)-2481 in a phosphatidylinositol 3-kinase-dependent manner, rapamycin acutely inhibits insulin-stimulated mTOR Ser(P)-2481 in mTORC1 but not mTORC2. By interrogating diverse mTORC1 regulatory input, we find that without exception mTORC1-activating signals promote, whereas mTORC1-inhibitory signals decrease mTORC1-associated mTOR Ser(P)-2481. These data suggest that mTORC1- and likely mTORC2-associated mTOR Ser-2481 autophosphorylation directly monitors intrinsic mTORC-specific catalytic activity and reveal that rapamycin inhibits mTORC1 signaling in vivo by reducing mTORC1 catalytic activity. PMID:20022946

  12. Articulatory Parameters.

    Science.gov (United States)

    Ladefoged, Peter

    1980-01-01

    Summarizes the 16 parameters hypothesized to be necessary and sufficient for linguistic phonetic specifications. Suggests seven parameters affecting tongue shapes, three determining the positions of the lips, one controlling the position of the velum, four varying laryngeal actions, and one controlling respiratory activity. (RL)

  13. Brandon mathematical model describing the effect of calcination and reduction parameters on specific surface area of UO{sub 2} powders

    Energy Technology Data Exchange (ETDEWEB)

    Hung, Nguyen Trong; Thuan, Le Ba [Institute for Technology of Radioactive and Rare Elements (ITRRE), 48 Lang Ha, Dong Da, Ha Noi (Viet Nam); Van Khoai, Do [Micro-Emission Ltd., 1-1 Asahidai, Nomi, Ishikawa, 923-1211 (Japan); Lee, Jin-Young, E-mail: jinlee@kigam.re.kr [Convergence Research Center for Development of Mineral Resources (DMR), Korea Institute of Geoscience and Mineral Resources (KIGAM), Daejeon, 305-350 (Korea, Republic of); Jyothi, Rajesh Kumar, E-mail: rkumarphd@kigam.re.kr [Convergence Research Center for Development of Mineral Resources (DMR), Korea Institute of Geoscience and Mineral Resources (KIGAM), Daejeon, 305-350 (Korea, Republic of)

    2016-06-15

    Uranium dioxide (UO{sub 2}) powder has been widely used to prepare fuel pellets for commercial light water nuclear reactors. Among typical characteristics of the powder, specific surface area (SSA) is one of the most important parameter that determines the sintering ability of UO{sub 2} powder. This paper built up a mathematical model describing the effect of the fabrication parameters on SSA of UO{sub 2} powders. To the best of our knowledge, the Brandon model is used for the first time to describe the relationship between the essential fabrication parameters [reduction temperature (T{sub R}), calcination temperature (T{sub C}), calcination time (t{sub C}) and reduction time (t{sub R})] and SSA of the obtained UO{sub 2} powder product. The proposed model was tested with Wilcoxon's rank sum test, showing a good agreement with the experimental parameters. The proposed model can be used to predict and control the SSA of UO{sub 2} powder.

  14. [THE INFLUENCE OF CYTOFLAVIN AND CARDIOXIPIN ON THE PARAMETERS OF 24-HOUR ARTERIAL PRESSURE MONITORING IN PATIENTS WITH CHRONIC CEREBRAL CIRCULATION INSUFFICIENCY, ARTERIAL HYPERTENSION AND HYPERCHOLESTEROLEMIA].

    Science.gov (United States)

    Vodop'ianova, O A; Moiseeva, I Ia; Rodina, O P; Kustikova, I N; Antropova, N V

    2015-01-01

    This comparative study of the influence of cytoflavin and cardioxipin on the parameters of 24-hour arterial pressure monitoring in 56 patients with chronic cerebral circulation insufficiency, arterial hypertension and hypercholesterolemia included 32 women and 24 men aged 42-72 years divided into 3 groups matchedfor the stage of diseases, age, sex, severity of AH, total cholesterol level, and antihypertensive therapy. Patients of group 1 were treated without cytoflavin and cardioxipin. Those in group 2 received daily i/v droplet infusion of 10 mg/kg cardioxipin (20-30 droplets/min). Patients of group 3 were given daily i/v droplet infusion of 10 ml cytoflavin in 200 ml 0.9% sodium chloride solution for 10 days. 24-hour arterial pressure monitoring was used to estimate the influence of the two drugs on systolic and diastolic pressure, its daily rhythm, AP variability and frequency of elevation. The study showed that both therapeutic modalities improved daily AP rhythm as manifested in a significant increase of the number of patients with the dipper rhythm and a decrease in the number of systolic/diastolic non-dipper patients. Moreover cytoflavin significantly decreased the number of systolic over-dippers compared with control group.

  15. Integrated Information Support System (IISS). Volume 6. Network Transaction Manager Subsystem. Part 5. NTM Monitor Product Specification.

    Science.gov (United States)

    1985-11-01

    2032)] HOST-LINK-TABLE - RECED RET-STATUS - DSPLY [1(5)] INCLUDE FILES: SNDARG - ARGUMENTS TO CALL SENDMG CHISTS - CHECK STATUSS MTRCMN - MONITOR... CHISTS - CHECK STATUS SNDARG - ARGUMENTS TO CALL SENDMG MTRCMN - MONITOR COMMON BLOCK TBLAPC - THIS IS THE APC STATUS TABLE .... A HOST GLOBALU TBLHST...TABLE - RECRD HOST-STATUS-TABLE - RECRD LINK-STATUS-TABLE - RECRD) HOST-LINK-TABLE - RECRD RET-STATUS - DSPLY [1(5)] INCLUDE FILES: CHISTS - CHECK

  16. Breed-specific hematological phenotypes in the dog: a natural resource for the genetic dissection of hematological parameters in a mammalian species.

    Directory of Open Access Journals (Sweden)

    Jennifer Lawrence

    Full Text Available Remarkably little has been published on hematological phenotypes of the domestic dog, the most polymorphic species on the planet. Information on the signalment and complete blood cell count of all dogs with normal red and white blood cell parameters judged by existing reference intervals was extracted from a veterinary database. Normal hematological profiles were available for 6046 dogs, 5447 of which also had machine platelet concentrations within the reference interval. Seventy-five pure breeds plus a mixed breed control group were represented by 10 or more dogs. All measured parameters except mean corpuscular hemoglobin concentration (MCHC varied with age. Concentrations of white blood cells (WBCs, neutrophils, monocytes, lymphocytes, eosinophils and platelets, but not red blood cell parameters, all varied with sex. Neutering status had an impact on hemoglobin concentration, mean corpuscular hemoglobin (MCH, MCHC, and concentrations of WBCs, neutrophils, monocytes, lymphocytes and platelets. Principal component analysis of hematological data revealed 37 pure breeds with distinctive phenotypes. Furthermore, all hematological parameters except MCHC showed significant differences between specific individual breeds and the mixed breed group. Twenty-nine breeds had distinctive phenotypes when assessed in this way, of which 19 had already been identified by principal component analysis. Tentative breed-specific reference intervals were generated for breeds with a distinctive phenotype identified by comparative analysis. This study represents the first large-scale analysis of hematological phenotypes in the dog and underlines the important potential of this species in the elucidation of genetic determinants of hematological traits, triangulating phenotype, breed and genetic predisposition.

  17. Specific heat flow rate: an on-line monitor and potential control variable of specific metabolic rate in animal cell culture that combines microcalorimetry with dielectric spectroscopy.

    Science.gov (United States)

    Guan, Y; Evans, P M; Kemp, R B

    1998-06-05

    One of the requirements for enhanced productivity by the animal culture systems used in biotechnology is the direct assessment of the metabolic rate by on-line biosensors. Based on the fact that cell growth is associated with an enthalpy change, it is shown that the specific heat flow rate is stoichiometrically related to the net specific rates of substrates, products, and indeed to specific growth rate, and therefore a direct reflection of metabolic rate. Heat flow rate measured by conduction calorimetry has a technical advantage over estimates for many material flows which require assays at a minimum of two discrete times to give the rate. In order to make heat flow rate specific to the amount of the living cellular system, it would be advantageous to divide it by viable biomass. This requirement has been fulfilled by combining a continuous flow microcalorimeter ex situ with a dielectric spectroscope in situ, the latter measuring the viable cell mass volume fraction. The quality of the resulting biosensor for specific heat flow rate was illustrated using batch cultures of Chinese hamster ovary cells (CHO 320) producing recombinant human interferon-gamma (IFN-gamma) during growth in a stirred tank bioreactor under fully aerobic conditions. The measuring scatter of the probe was decreased significantly by applying the moving average technique to the two participant signals. It was demonstrated that the total metabolic rate of the cells, as indicated by the specific heat flow rate sensor, decreased with increasing time in batch culture, coincident with the decline in the two major substrates, glucose and glutamine, and the accumulation of the by-products, ammonia and lactate. Furthermore, the specific heat flow rate was an earlier indicator of substrate depletion than the flow rate alone. The calorimetric-respirometric ratio showed the intensive participation of anaerobic processes during growth and the related IFN-gamma production. Specific heat flow rate was

  18. The influence of electric transformers' specific parameters modification on power distributions and on technological appropriate consumption (tac within the energetic system

    Directory of Open Access Journals (Sweden)

    Ion VONCILA

    2005-12-01

    Full Text Available The paper deals with a comparative analysis – using DINIS(E programming environment – of the way electric transformers' specific variables (Iron losses, the parameters of the equivalent scheme, the level of primary power supply, etc. influences power distributions, active and reactive, from a well-defined contour within the energetic system. Also, the paper deals with the way interconnection of a great number of transformation units, with different functional characteristics may influence the level of losses within the global system – result as a consequence of multiple connections – level ultimately emphasised by the technological appropriate consumption (TAC .

  19. First study of the evolution of the SeDeM expert system parameters based on percolation theory: Monitoring of their critical behavior.

    Science.gov (United States)

    Galdón, Eduardo; Casas, Marta; Gayango, Manuel; Caraballo, Isidoro

    2016-12-01

    The deep understanding of products and processes has become a requirement for pharmaceutical industries to follow the Quality by Design principles promoted by the regulatory authorities. With this aim, SeDeM expert system was developed as a useful preformulation tool to predict the likelihood to process drugs and excipients through direct compression. SeDeM system is a step forward in the rational development of a formulation, allowing the normalisation of the rheological parameters and the identification of the weaknesses and strengths of a powder or a powder blend. However, this method is based on the assumption of a linear behavior of disordered systems. As percolation theory has demonstrated, powder blends behave as non-linear systems that can suffer abrupt changes in their properties near to geometrical phase transitions of the components. The aim of this paper was to analyze for the first time the evolution of the SeDeM parameters in drug/excipient powder blends from the point of view of the percolation theory and to compare the changes predicted by SeDeM with the predictions of Percolation theory. For this purpose, powder blends of lactose and theophylline with varying concentrations of the model drug have been prepared and the SeDeM analysis has been applied to each blend in order to monitor the evolution of their properties. On the other hand, percolation thresholds have been estimated for these powder blends where critical points have been found for important rheological parameters as the powder flow. Finally, the predictions of percolation theory and SeDeM have been compared concluding that percolation theory can complement the SeDeM method for a more accurate estimation of the Design Space.

  20. Sensor for monitoring plasma parameters

    CERN Document Server

    Bolshakov, A A; Sharma, S P; Bol'shakov, Alexander A.; Cruden, Brett A.; Sharma, Surendra P.

    2004-01-01

    A spectrally tunable VCSEL (vertical cavity surface-emitting laser) was used as part of sensing hardware for measurements of the radial-integrated gas temperature inside an inductively coupled plasma reactor. The data were obtained by profiling the Doppler-broadened absorption of metastable Ar atoms at 763.51 nm in argon and argon/nitrogen plasmas (3, 45, and 90% N2 in Ar) at pressure 0.5-70 Pa and inductive power of 100 and 300 W. The results were compared to rotational temperature derived from the N2 emission at the (0,0) transition of the C - B system. The differences in integrated rotational and Doppler temperatures were attributed to non-uniform spatial distributions of both temperature and thermometric species (Ar* and N2*) that varied depending on conditions. A two-dimensional, two-temperature fluid plasma simulation was employed to explain these differences. This work should facilitate further development of a miniature sensor for non-intrusive acquisition of data (temperature and densities of multipl...

  1. Proposal of a Novel Setup for Linac Monitoring Using a Specifically Designed Plastic Scintillator and a Spectrophotometer

    Directory of Open Access Journals (Sweden)

    F. Moreno-Barbosa

    2016-08-01

    Full Text Available In this work we report the design, implementation and results of an alternative monitoring system for a linear accelerator (LINAC used in medical therapy. The system proposed consist in as lab of scintillator plastic with a wavelength shifter fiberoptically coupled to collect the light generated,and a Spectrophotometer Ocean Optics USB4000 as analyzer. The control was made with two computers, one into the therapy room and another, using a VNC (Virtual Network Computer and Ethernet wire, outside of the room in order to avoid radiation exposure. The LINAC dose range covered was 1, 2, 3, 4, 5, 10, 20, 30 and 40 Monitor Units (MU with 6 and 18 MeV energy photons. The spectrum obtained was compared with the measures of the LINAC ionization camera used to calibrate it. The results obtained allow us to propose this device as an alternative method to monitor the LINAC performance.

  2. Support Vector Data Description Model to Map Specific Land Cover with Optimal Parameters Determined from a Window-Based Validation Set

    Directory of Open Access Journals (Sweden)

    Jinshui Zhang

    2017-04-01

    Full Text Available This paper developed an approach, the window-based validation set for support vector data description (WVS-SVDD, to determine optimal parameters for support vector data description (SVDD model to map specific land cover by integrating training and window-based validation sets. Compared to the conventional approach where the validation set included target and outlier pixels selected visually and randomly, the validation set derived from WVS-SVDD constructed a tightened hypersphere because of the compact constraint by the outlier pixels which were located neighboring to the target class in the spectral feature space. The overall accuracies for wheat and bare land achieved were as high as 89.25% and 83.65%, respectively. However, target class was underestimated because the validation set covers only a small fraction of the heterogeneous spectra of the target class. The different window sizes were then tested to acquire more wheat pixels for validation set. The results showed that classification accuracy increased with the increasing window size and the overall accuracies were higher than 88% at all window size scales. Moreover, WVS-SVDD showed much less sensitivity to the untrained classes than the multi-class support vector machine (SVM method. Therefore, the developed method showed its merits using the optimal parameters, tradeoff coefficient (C and kernel width (s, in mapping homogeneous specific land cover.

  3. Development times and age-specific life table parameters of the native lady beetle species Coccinella novemnotata (Coleoptera: Coccinellidae) and its invasive congener Coccinella septempunctata (Coleoptera: Coccinellidae).

    Science.gov (United States)

    Ugine, Todd A; Losey, John E

    2014-08-01

    To determine if differences in life history parameters contribute to native species exclusion, immature development times, larval survivorship, reproductive life history parameters, and age-specific life tables were determined for two populations (eastern United States and western United States) of ninespotted lady beetles (Coccinella novemnotata Herbst) and one population of sevenspotted lady beetles (Coccinella septempunctata L.). Developing larvae were provided an ad libitum diet of pea aphids (Acyrthosiphon pisum Harris) at a constant temperature of 25°C. The first and fourth larval stadia of C. novemnotata were significantly longer than that of C. septempunctata, as was their total development time from egg to newly eclosed adult. Stage-specific developmental mortality was low for both species and did not exceed 7% for the entire development period. The preoviposition period of the two C. novemnotata populations was significantly shorter (15-20%) than that of C. septempunctata. C. novemnotata from both locations laid significantly fewer total eggs than C. septempunctata (34-40% fewer) over the 31-d test period, and also fewer eggs per day (37-43% fewer). The net reproductive rate of the C. novemnotata populations was 42-50% lower than that of C. septempunctata as was C. novemnotata's intrinsic rate of natural increase (rm: 0.1716 and 0.1840 vs. 0.1959 for western and eastern C. novemnotata and C. septempunctata, respectively).

  4. Support Vector Data Description Model to Map Specific Land Cover with Optimal Parameters Determined from a Window-Based Validation Set.

    Science.gov (United States)

    Zhang, Jinshui; Yuan, Zhoumiqi; Shuai, Guanyuan; Pan, Yaozhong; Zhu, Xiufang

    2017-04-26

    This paper developed an approach, the window-based validation set for support vector data description (WVS-SVDD), to determine optimal parameters for support vector data description (SVDD) model to map specific land cover by integrating training and window-based validation sets. Compared to the conventional approach where the validation set included target and outlier pixels selected visually and randomly, the validation set derived from WVS-SVDD constructed a tightened hypersphere because of the compact constraint by the outlier pixels which were located neighboring to the target class in the spectral feature space. The overall accuracies for wheat and bare land achieved were as high as 89.25% and 83.65%, respectively. However, target class was underestimated because the validation set covers only a small fraction of the heterogeneous spectra of the target class. The different window sizes were then tested to acquire more wheat pixels for validation set. The results showed that classification accuracy increased with the increasing window size and the overall accuracies were higher than 88% at all window size scales. Moreover, WVS-SVDD showed much less sensitivity to the untrained classes than the multi-class support vector machine (SVM) method. Therefore, the developed method showed its merits using the optimal parameters, tradeoff coefficient (C) and kernel width (s), in mapping homogeneous specific land cover.

  5. Dietary galactooligosaccharide elicits positive effects on non-specific immune parameters and growth performance in Caspian white fish (Rutilus frisii kutum) fry.

    Science.gov (United States)

    Hoseinifar, Seyed Hossein; Zoheiri, Fazel; Dadar, Maryam; Rufchaei, Rudabeh; Ringø, Einar

    2016-09-01

    An eight-weeks feeding trial was conducted to investigate the effects of galactooligosaccharide (GOS), on the skin and serum non-specific immune parameters and growth performance of Caspian white fish (Rutilus frisii kutum) fry. Fish (2.07 ± 0.08 g) were fed different levels of GOS (0%, 1%, 2% and 3%). No significant (P > 0.05) difference was observed in mucus protease activity, but inclusion of 1% GOS significantly (P < 0.05) elevated total immunoglobulin (Ig) level and lysozyme activity. Evaluation of serum non-specific immune parameters revealed significant (P < 0.05) increase in serum total Ig and lysozyme activity of fish fed 1% or 2% GOS compared those of fish fed control diet. Furthermore, the serum alternative haemolytic complement activity (ACH50) was significantly (P < 0.05) elevated in all prebiotic groups regardless of inclusion levels. Administration of GOS in diet significantly (P < 0.05) improved growth performance and feed utilisation. The results of the present study revealed that GOS administration is beneficial by improving immune response and growth performance of Caspian white fish.

  6. Reduced uncertainty of regional scale CLM predictions of net carbon fluxes and leaf area indices with estimated plant-specific parameters

    Science.gov (United States)

    Post, Hanna; Hendricks Franssen, Harrie-Jan; Han, Xujun; Baatz, Roland; Montzka, Carsten; Schmidt, Marius; Vereecken, Harry

    2016-04-01

    Reliable estimates of carbon fluxes and states at regional scales are required to reduce uncertainties in regional carbon balance estimates and to support decision making in environmental politics. In this work the Community Land Model version 4.5 (CLM4.5-BGC) was applied at a high spatial resolution (1 km2) for the Rur catchment in western Germany. In order to improve the model-data consistency of net ecosystem exchange (NEE) and leaf area index (LAI) for this study area, five plant functional type (PFT)-specific CLM4.5-BGC parameters were estimated with time series of half-hourly NEE data for one year in 2011/2012, using the DiffeRential Evolution Adaptive Metropolis (DREAM) algorithm, a Markov Chain Monte Carlo (MCMC) approach. The parameters were estimated separately for four different plant functional types (needleleaf evergreen temperate tree, broadleaf deciduous temperate tree, C3-grass and C3-crop) at four different sites. The four sites are located inside or close to the Rur catchment. We evaluated modeled NEE for one year in 2012/2013 with NEE measured at seven eddy covariance sites in the catchment, including the four parameter estimation sites. Modeled LAI was evaluated by means of LAI derived from remotely sensed RapidEye images of about 18 days in 2011/2012. Performance indices were based on a comparison between measurements and (i) a reference run with CLM default parameters, and (ii) a 60 instance CLM ensemble with parameters sampled from the DREAM posterior probability density functions (pdfs). The difference between the observed and simulated NEE sum reduced 23% if estimated parameters instead of default parameters were used as input. The mean absolute difference between modeled and measured LAI was reduced by 59% on average. Simulated LAI was not only improved in terms of the absolute value but in some cases also in terms of the timing (beginning of vegetation onset), which was directly related to a substantial improvement of the NEE estimates in

  7. SU-E-T-176: Clinical Experience of Brass Mesh Bolus: Patient-Specific Parameters as Predictors of Measured Dosimetric Effect

    Energy Technology Data Exchange (ETDEWEB)

    Yock, A; Manger, R; Einck, J; Yashar, C; Sanghvi, P; Hattangadi-Gluth, J; Cervino, L [University of California - San Diego, La Jolla, CA (United States)

    2015-06-15

    Purpose: Increasingly, brass mesh bolus is used to insure dosimetric coverage of the skin for patients treated post-mastectomy for breast cancer. Contribution of photoelectrons from interactions between the bolus and the primary beam increases dose superficially without affecting dose at greater depths. We present our experience using brass mesh bolus – including patients for whom the bolus was dosimetrically inadequate – along with analysis of relevant patient-specific parameters. Methods: Optically-stimulated luminescent dosimeters (OSLDs) were used to determine the effect of the bolus for 15 patients. They were positioned beneath the bolus within the tangent fields at three positions: 1.5–3cm inside the medial and lateral field edges, and midway between the two. All OSLDs were midfield in the cranial-caudal direction. The measurements were compared with patient-specific parameters including separation, chest wall/breast tissue thickness, beam angle incidence, and planned surface dose. Results: The average OSLD measurement at the medial field edge, midfield, and lateral field edge position was 86.8%, 101.8%, and 92.8% of the prescription dose, respectively. A measurement for one patient was low enough (77.0%) to warrant a switch to an alternative type of bolus. Anatomic parameters were analyzed to investigate the low dose in this case, not observed in the planning system. The patient was observed to have a thin chest wall and very oblique beam angles. A second patient was also switched to an alternative type of bolus due to her being high risk and treated with an electron patch that extended onto the breast. Conclusion: Brass mesh bolus increases dose superficially while leaving dose at greater depths unaffected. However, our results suggest that this effect may be insufficient in patients with a thin chest wall or very oblique beam angles. More data and analysis is necessary to proactively identify patients for whom brass mesh bolus is effective.

  8. The association of serum gamma-glutamyl transpeptidase level and other laboratory parameters with blood pressure in hypertensive patients under ambulatory blood pressure monitoring

    Directory of Open Access Journals (Sweden)

    Ortakoyluoglu A

    2016-09-01

    Full Text Available Adile Ortakoyluoglu, Betul Boz, Oguzhan Sitki Dizdar, Deniz Avci, Ali Cetinkaya, Osman Baspinar Department of Internal Medicine, Kayseri Training and Research Hospital, Kayseri, Turkey Background: Hypertension is a very important cause of morbidity and mortality. Serum gamma-glutamyl transpeptidase (GGT is a biomarker of oxidative stress and associated with increased risk of hypertension and diabetes. The aim of this study was to evaluate the association of serum GGT level, which is an early marker of inflammation and endothelial dysfunction, with the deterioration of the diurnal rhythm of the blood pressure.Methods: A total of 171 patients with hypertension were included in this study. Patients whose nighttime mean blood pressure, measured via ambulatory blood pressure monitoring, decreased between 10% and 20% compared with the daytime mean blood pressure were defined as “dippers”, whereas patients with a nighttime blood pressure decrease lower than 10% were defined as “non-dippers”.Results: A total of 99 hypertensive patients (65 females/34 males were classified as dippers and 72 patients (48 females/24 males as non-dippers. The mean age of the non-dipper group was significantly greater than the dipper group. Serum GGT, C-reactive protein and uric acid levels were significantly higher among patients in the non-dipper group. Negative correlations were detected between GGT levels and diurnal systolic and diastolic blood pressure decreases.Conclusion: Our findings revealed that GGT level was higher in the non-dipper group, and was negatively correlated with the nighttime decrease of diurnal blood pressure. C-reactive protein and uric acid levels were also higher in the non-dipper group. However, future randomized controlled prospective studies with larger patient populations are necessary to confirm our findings. Keywords: gamma-glutamyl transpeptidase, hypertension, ambulatory blood pressure monitoring, laboratory parameters

  9. Monitoring for a specific management objective: protection of shorebird foraging habitat adjacent to a waste water treatment plant.

    Science.gov (United States)

    Morris, Liz; Petch, David; May, David; Steele, William K

    2017-05-01

    Intertidal invertebrates are often used in environmental monitoring programs as they are good indicators of water quality and an important food source for many species of fish and birds. We present data from a monitoring program where the primary aim is to report on the condition of the potential invertebrate prey abundance, biomass and diversity for migrating shorebirds on mudflats adjacent to a waste water treatment plant in a Ramsar listed wetland in Victoria, Australia. A key threat to the foraging habitat at this site has been assessed as a reduction in potential prey items as a result of the changes to the waste water treatment processes. We use control charts, which summarise data from intertidal mudflats across the whole shoreline of the adjacent waste water treatment plant, to elicit a management response when trigger levels are reached. We then examine data from replicate discharge and control sites to determine the most appropriate management response. The monitoring program sits within an adaptive management framework where management decisions are reviewed and the data is examined at different scales to evaluate and modify our models of the likely outcomes of management actions. This study provides a demonstration of the process undertaken in a year when trigger levels were reached and a management decision was required. This highlights the importance of monitoring data from a range of scales in reducing uncertainty and improving decision making in complex systems.

  10. A parameter for IL-10 and TGF-ß mediated regulation of HIV-1 specific T cell activation provides novel information and relates to progression markers.

    Directory of Open Access Journals (Sweden)

    Andreas Lind

    Full Text Available HIV replication is only partially controlled by HIV-specific activated effector T cells in chronic HIV infection and strategies are warranted to improve their efficacy. Chronic T cell activation is generally accompanied by regulation of antigen-specific T cell responses which may impair an effective control of chronic infections. The impact of HIV-induced T cell regulation on individual patients' disease progression is largely unknown, since classical T cell activation assays reflect net activation with regulation as unknown contributing factor. We here explore a quantitative parameter for antigen-induced cytokine-mediated regulation (R(AC of HIV-specific effector T cell activation by functional antibody-blockade of IL-10 and transforming growth factor-β. HIV Env- and Gag-specific T cell activation and R(AC were estimated in peripheral blood mononuclear cells from 30 treatment-naïve asymptomatic HIV-infected progressors (CD4 count 472/µl, HIV RNA 37500 copies/ml stimulated with overlapping peptide panels for 6 days. R(AC was estimated from differences in T cell activation between normal and blocked cultures, and related to annual CD4 loss, immune activation (CD38 and microbial translocation (plasma lipopolysaccharides. R(AC was heterogeneously distributed between individual patients and the two HIV antigens. Notably, RAC did not correlate to corresponding classical activation. Env R(AC correlated with CD38 and CD4 loss rates (r> = 0.37, p = <0.046 whereas classical Gag activation tended to correlate with HIV RNA (r = -0.35, p = 0.06. 14 patients (47% with low R(AC's to both Env and Gag had higher CD8 counts (p = 0.014 and trends towards lower annual CD4 loss (p = 0.056 and later start with antiretroviral treatment (p = 0.07 than the others. In contrast, patients with high RAC to both Env and Gag (n = 8 had higher annual CD4 loss (p = 0.034 and lower CD8 counts (p = 0.014. R(AC to Env and Gag was not

  11. A parameter for IL-10 and TGF-ß mediated regulation of HIV-1 specific T cell activation provides novel information and relates to progression markers.

    Science.gov (United States)

    Lind, Andreas; Brekke, Kristin; Pettersen, Frank Olav; Mollnes, Tom Eirik; Trøseid, Marius; Kvale, Dag

    2014-01-01

    HIV replication is only partially controlled by HIV-specific activated effector T cells in chronic HIV infection and strategies are warranted to improve their efficacy. Chronic T cell activation is generally accompanied by regulation of antigen-specific T cell responses which may impair an effective control of chronic infections. The impact of HIV-induced T cell regulation on individual patients' disease progression is largely unknown, since classical T cell activation assays reflect net activation with regulation as unknown contributing factor. We here explore a quantitative parameter for antigen-induced cytokine-mediated regulation (R(AC) of HIV-specific effector T cell activation by functional antibody-blockade of IL-10 and transforming growth factor-β. HIV Env- and Gag-specific T cell activation and R(AC) were estimated in peripheral blood mononuclear cells from 30 treatment-naïve asymptomatic HIV-infected progressors (CD4 count 472/µl, HIV RNA 37500 copies/ml) stimulated with overlapping peptide panels for 6 days. R(AC) was estimated from differences in T cell activation between normal and blocked cultures, and related to annual CD4 loss, immune activation (CD38) and microbial translocation (plasma lipopolysaccharides). R(AC) was heterogeneously distributed between individual patients and the two HIV antigens. Notably, RAC did not correlate to corresponding classical activation. Env R(AC) correlated with CD38 and CD4 loss rates (r> = 0.37, p = <0.046) whereas classical Gag activation tended to correlate with HIV RNA (r = -0.35, p = 0.06). 14 patients (47%) with low R(AC)'s to both Env and Gag had higher CD8 counts (p = 0.014) and trends towards lower annual CD4 loss (p = 0.056) and later start with antiretroviral treatment (p = 0.07) than the others. In contrast, patients with high RAC to both Env and Gag (n = 8) had higher annual CD4 loss (p = 0.034) and lower CD8 counts (p = 0.014). R(AC) to Env and Gag was not

  12. Measuring submaximal performance parameters to monitor fatigue and predict cycling performance: a case study of a world-class cyclo-cross cyclist.

    Science.gov (United States)

    Lamberts, Robert P; Rietjens, Gerard J; Tijdink, Hendrik H; Noakes, Timothy D; Lambert, Michael I

    2010-01-01

    Recently a novel submaximal test, known as the Lamberts and Lambert submaximal cycle test (LSCT), has been developed with the purpose of monitoring and predicting changes in cycling performance. Although this test has been shown to be reliable and able to predict cycling performance, it is not known whether it can measure changes in training status. Therefore, the aim of this study was to determine whether the LSCT is able to track changes in performance parameters, and objective and subjective markers of well-being. A world class cyclo-cross athlete (31 years) volunteered to participate in a 10-week observational study. Before and after the study, a peak power output (PPO) test with respiratory gas analysis (VO(2max)) and a 40-km time trial (40-km TT) test were performed. Training data were recorded in a training logbook with a daily assessment of well-being, while a weekly LSCT was performed. After the training period all performance parameters had improved by a meaningful amount (PPO +5.2%; 40-km TT time -2.5%; VO(2max) +1.4%). Increased training loads during weeks 2 and 6 and the subsequent training-induced fatigue was reflected in the increased well-being scores. Changes during the LSCT were most clearly notable in (1) increased power during the first minute of third stage, (2) increased rating of perceived exertion during second and third stages, and (3) a faster heart rate recovery after the third stage. In conclusion, these data suggest that the LSCT is able to track changes in training status and detect the consequences of sharp increases in training loads which seem to be associated with accumulating fatigue.

  13. Non-Invasive Fetal Monitoring: A Maternal Surface ECG Electrode Placement-Based Novel Approach for Optimization of Adaptive Filter Control Parameters Using the LMS and RLS Algorithms.

    Science.gov (United States)

    Martinek, Radek; Kahankova, Radana; Nazeran, Homer; Konecny, Jaromir; Jezewski, Janusz; Janku, Petr; Bilik, Petr; Zidek, Jan; Nedoma, Jan; Fajkus, Marcel

    2017-05-19

    This paper is focused on the design, implementation and verification of a novel method for the optimization of the control parameters (such as step size μ and filter order N) of LMS and RLS adaptive filters used for noninvasive fetal monitoring. The optimization algorithm is driven by considering the ECG electrode positions on the maternal body surface in improving the performance of these adaptive filters. The main criterion for optimal parameter selection was the Signal-to-Noise Ratio (SNR). We conducted experiments using signals supplied by the latest version of our LabVIEW-Based Multi-Channel Non-Invasive Abdominal Maternal-Fetal Electrocardiogram Signal Generator, which provides the flexibility and capability of modeling the principal distribution of maternal/fetal ECGs in the human body. Our novel algorithm enabled us to find the optimal settings of the adaptive filters based on maternal surface ECG electrode placements. The experimental results further confirmed the theoretical assumption that the optimal settings of these adaptive filters are dependent on the ECG electrode positions on the maternal body, and therefore, we were able to achieve far better results than without the use of optimization. These improvements in turn could lead to a more accurate detection of fetal hypoxia. Consequently, our approach could offer the potential to be used in clinical practice to establish recommendations for standard electrode placement and find the optimal adaptive filter settings for extracting high quality fetal ECG signals for further processing. Ultimately, diagnostic-grade fetal ECG signals would ensure the reliable detection of fetal hypoxia.

  14. BayesPI - a new model to study protein-DNA interactions: a case study of condition-specific protein binding parameters for Yeast transcription factors

    Directory of Open Access Journals (Sweden)

    Morigen

    2009-10-01

    Full Text Available Abstract Background We have incorporated Bayesian model regularization with biophysical modeling of protein-DNA interactions, and of genome-wide nucleosome positioning to study protein-DNA interactions, using a high-throughput dataset. The newly developed method (BayesPI includes the estimation of a transcription factor (TF binding energy matrices, the computation of binding affinity of a TF target site and the corresponding chemical potential. Results The method was successfully tested on synthetic ChIP-chip datasets, real yeast ChIP-chip experiments. Subsequently, it was used to estimate condition-specific and species-specific protein-DNA interaction for several yeast TFs. Conclusion The results revealed that the modification of the protein binding parameters and the variation of the individual nucleotide affinity in either recognition or flanking sequences occurred under different stresses and in different species. The findings suggest that such modifications may be adaptive and play roles in the formation of the environment-specific binding patterns of yeast TFs and in the divergence of TF binding sites across the related yeast species.

  15. Assessing quality of Medicago sativa silage by monitoring bacterial composition with single molecule, real-time sequencing technology and various physiological parameters

    Science.gov (United States)

    Bao, Weichen; Mi, Zhihui; Xu, Haiyan; Zheng, Yi; Kwok, Lai Yu; Zhang, Heping; Zhang, Wenyi

    2016-01-01

    The present study applied the PacBio single molecule, real-time sequencing technology (SMRT) in evaluating the quality of silage production. Specifically, we produced four types of Medicago sativa silages by using four different lactic acid bacteria-based additives (AD-I, AD-II, AD-III and AD-IV). We monitored the changes in pH, organic acids (including butyric acid, the ratio of acetic acid/lactic acid, γ-aminobutyric acid, 4-hyroxy benzoic acid and phenyl lactic acid), mycotoxins, and bacterial microbiota during silage fermentation. Our results showed that the use of the additives was beneficial to the silage fermentation by enhancing a general pH and mycotoxin reduction, while increasing the organic acids content. By SMRT analysis of the microbial composition in eight silage samples, we found that the bacterial species number and relative abundances shifted apparently after fermentation. Such changes were specific to the LAB species in the additives. Particularly, Bacillus megaterium was the initial dominant species in the raw materials; and after the fermentation process, Pediococcus acidilactici and Lactobacillus plantarum became the most prevalent species, both of which were intrinsically present in the LAB additives. Our data have demonstrated that the SMRT sequencing platform is applicable in assessing the quality of silage. PMID:27340760

  16. Assessing quality of Medicago sativa silage by monitoring bacterial composition with single molecule, real-time sequencing technology and various physiological parameters.

    Science.gov (United States)

    Bao, Weichen; Mi, Zhihui; Xu, Haiyan; Zheng, Yi; Kwok, Lai Yu; Zhang, Heping; Zhang, Wenyi

    2016-06-24

    The present study applied the PacBio single molecule, real-time sequencing technology (SMRT) in evaluating the quality of silage production. Specifically, we produced four types of Medicago sativa silages by using four different lactic acid bacteria-based additives (AD-I, AD-II, AD-III and AD-IV). We monitored the changes in pH, organic acids (including butyric acid, the ratio of acetic acid/lactic acid, γ-aminobutyric acid, 4-hyroxy benzoic acid and phenyl lactic acid), mycotoxins, and bacterial microbiota during silage fermentation. Our results showed that the use of the additives was beneficial to the silage fermentation by enhancing a general pH and mycotoxin reduction, while increasing the organic acids content. By SMRT analysis of the microbial composition in eight silage samples, we found that the bacterial species number and relative abundances shifted apparently after fermentation. Such changes were specific to the LAB species in the additives. Particularly, Bacillus megaterium was the initial dominant species in the raw materials; and after the fermentation process, Pediococcus acidilactici and Lactobacillus plantarum became the most prevalent species, both of which were intrinsically present in the LAB additives. Our data have demonstrated that the SMRT sequencing platform is applicable in assessing the quality of silage.

  17. Association between central obesity and circadian parameters of blood pressure from the korean ambulatory blood pressure monitoring registry: Kor-ABP registry.

    Science.gov (United States)

    Kang, In Sook; Pyun, Wook Bum; Shin, Jinho; Kim, Ju Han; Kim, Soon Gil; Shin, Gil Ja

    2013-10-01

    Central obesity has been reported as a risk for atherosclerosis and metabolic syndrome. The influence of central obesity on diurnal blood pressure (BP) has not been established. In this study, we investigated the influence of central obesity on the circadian parameters of BP by 24 hr ambulatory BP monitoring. Total 1,290 subjects were enrolled from the Korean Ambulatory BP registry. Central obesity was defined as having a waist circumference≥90 cm in males and ≥85 cm in females. The central-obese group had higher daytime systolic BP (SBP), nighttime SBP and diastolic BP (DBP) than the non-obese group (all, P<0.001). There were no differences in nocturnal dipping (ND) patterns between the groups. Female participants showed a higher BP mean difference (MD) than male participants with concerns of central obesity (daytime SBP MD 5.28 vs 4.27, nighttime SBP MD 6.48 vs 2.72) and wider pulse pressure (PP). Central obesity within the elderly (≥65 yr) also showed a higher BP MD than within the younger group (daytime SBP MD 8.23 vs 3.87, daytime DBP 4.10 vs 1.59). In conclusion, central obesity has no influence on nocturnal dipping patterns. However, higher SBP and wider PP are associated with central obesity, which is accentuated in women.

  18. Identifying Pollutants in the Siret River Basin by Applying New Assessment Tools on Monitoring Data: the Correlation of Land Use and Physicochemical Parameter of Water Quality Analysis

    Directory of Open Access Journals (Sweden)

    Mănescu Andreea

    2014-10-01

    Full Text Available The Siret River are used as raw water source for different municipal water supply systems, yet the Siret River are used as receiving bodies by some inhabitants and industry. In the study the quality of the Siret River water was determinate using a Water Quality Index (WQI. Results are presented from a field study performed on the Bistrita, Moldova, Suceava, Siret, Şomuzu Mare, Trotuş and Tributary River in the study area Siret Basin Romania. The main objective of this study was to determine is to find correlations land use to indicators physical-chemical of water quality, to investigate pollution source is more responsible for river water quality. This is of interest not only research context, but also for supporting and facilitating the application analysis postullend in the Water Framework Directive (WFD (2000/60/CE for the establishment of programmers of measures. For this purpose a slightly impact pollution source municipal wastewater treatment, land uses, urban, forest, agriculture and mining was selected and intensively monitored during six years January 2006 - December 2011, sampling was determined to meet the WFD standards for confidence in twenty two different control section of the Siret Basin. The main measures to reduce emissions to the Siret River were calcium, ammonium, sulfate, residue fixed (RF, sodium, chloride, free detergent and municipal wastewater treatment, concentrated on point emission. The main contributor to diffuse this parameters increased when more percentage of land was dedicated to industry and urban and less to forest and mining.

  19. A simple novel approach for real-time monitoring of sodium gluconate production by on-line physiological parameters in batch fermentation by Aspergillus niger.

    Science.gov (United States)

    Lu, Fei; Wang, Zejian; Zhao, Wei; Chu, Ju; Zhuang, Yingping

    2016-02-01

    In this paper, approach for real-time monitoring of sodium gluconate (SG) fermentation was established for the first time by the equations which can calculate real-time key-parameters by on-line physiological data. Based on this approach, limiting factors were found out in initial fermentation F1 and then step-wise agitation increase and improved medium recipe were proposed in fermentation F2 and F3, respectively. The highest average SG production rate (16.58±0.91 g L(-1) h(-1)) was achieved in fermentation F3, which was 104.2% and 48.0% higher than those in fermentation F1 and F2, respectively. Meanwhile, due to shorter fermentation period (decreased from 34 h to 18.7 h), lower biomass (about 1.5 g L(-1)) and less by-product accumulation, the overall yield of 0.943±0.012 (mol mol(-1)) in fermentation F3 increased more than 16.0% compared to fermentation F1. This approach had been successfully applied to industrial fermentation and greatly improved SG production.

  20. Effect of clinical and laboratory parameters on quality of life in celiac patients using celiac disease-specific quality of life scores.

    Science.gov (United States)

    Lee, Jungmin; Clarke, Kofi

    2017-11-01

    Health-related quality of life (HR-QOL) in patients with celiac disease is reduced compared to the general population. We investigated the association between HR-QOL and clinical, laboratory findings using the previously validated CD-QOL (celiac disease-specific quality of life) instrument in patients with celiac disease. To our knowledge, no study has previously explored the relationship between HR-QOL and clinical, laboratory parameters in celiac patients. Patients who received care at the Allegheny Health Network Celiac Center, Pittsburgh, PA were asked to complete the CD-QOL questionnaire. A cross sectional study with predetermined clinical and laboratory parameters was performed. Data collected included IgA anti-tissue transglutaminase (tTG) antibody titers, iron studies, calcium, vitamin A, B12, 25 OH vitamin D, and E levels. Correlation between clinical findings and CD-QOL was also assessed. Seventy-eight out of 124 patients who completed the questionnaire was included in the analysis. Patients with concomitant irritable bowel syndrome (IBS) had significantly reduced HR-QOL with CD-QOL score of 52.4 ± 11.3 vs. 44.6 ± 12.9 in those without IBS (p = .009). There was no difference in HR-QOL in relation to IgA tTG titers or vitamin D levels. Of note, there was a trend towards correlation between higher level of vitamin E and better QOL (r = -0.236, p = .074). Celiac patients with concomitant IBS have reduced HR-QOL. There was no statistically significant association between HR-QOL and laboratory parameters or levels of micronutrients.

  1. Four parameters increase the sensitivity and specificity of the exon array analysis and disclose 25 novel aberrantly spliced exons in myotonic dystrophy.

    Science.gov (United States)

    Yamashita, Yoshihiro; Matsuura, Tohru; Shinmi, Jun; Amakusa, Yoshinobu; Masuda, Akio; Ito, Mikako; Kinoshita, Masanobu; Furuya, Hirokazu; Abe, Koji; Ibi, Tohru; Sahashi, Ko; Sahashi, Koo; Ohno, Kinji

    2012-06-01

    Myotonic dystrophy type 1 (DM1) is an RNA gain-of-function disorder in which abnormally expanded CTG repeats of DMPK sequestrate a splicing trans-factor MBNL1 and upregulate another splicing trans-factor CUGBP1. To identify a diverse array of aberrantly spliced genes, we performed the exon array analysis of DM1 muscles. We analyzed 72 exons by RT-PCR and found that 27 were aberrantly spliced, whereas 45 were not. Among these, 25 were novel and especially splicing aberrations of LDB3 exon 4 and TTN exon 45 were unique to DM1. Retrospective analysis revealed that four parameters efficiently detect aberrantly spliced exons: (i) the signal intensity is high; (ii) the ratio of probe sets with reliable signal intensities (that is, detection above background P-value=0.000) is high within a gene; (iii) the splice index (SI) is high; and (iv) SI is deviated from SIs of the other exons that can be estimated by calculating the deviation value (DV). Application of the four parameters gave rise to a sensitivity of 77.8% and a specificity of 95.6% in our data set. We propose that calculation of DV, which is unique to our analysis, is of particular importance in analyzing the exon array data.

  2. [Effectiveness of specific immunotherapy in the treatment of children and youngsters suffering from atopic dermatitis. Part III. Serum concentrations of selected immunologic parameters].

    Science.gov (United States)

    Silny, Wojciech; Czarnecka-Operacz, Magdalena; Silny, Pawel

    2005-01-01

    Etiology and pathomechanism of atopic dermatitis still remains partially unclear and therefore contemporary methods of treatment are not always satisfactory from the clinical standpoint. The aim of this study was to evaluate selected immunological parameters (tIgE, ECP, sIL-2R, IFN-gamma, IL-4,IL-5) in sera of atopic dermatitis patients in the course of specific immunotherapy performed for the time period of 3 years. Novo-Helisen Depot allergy vaccines of appropriate composition were used for the treatment of 36 children and youngsters with atopic dermatitis, allergic to house dust mites (24 patients) and grass pollen allergens (12 patients). The control group consisted of 20 patients with atopic dermatitis and analogous IgE-mediated airborne allergy who were treated with conventional methods. There was a clear difference between two investigated groups of patients in terms of immunological parameters. In the group treated with allergy vaccines serum concentrations of total IgE and ECP tended to decrease (p < 0.001) as well as sIL-2R (p < 0.01). On the contrary in the control group serum tIgE increased and IL-4 as well as IL-5 concentrations tended to increase significantly (p < 0.01; p < 0.05 respectively).

  3. 基于机械比能理论的复合钻井参数优选方法%Optimize Method of Drilling Parameter of Compound Drilling Based on Mechanical Specific Energy Theory

    Institute of Scientific and Technical Information of China (English)

    崔猛; 李佳军; 纪国栋; 陈永恒

    2014-01-01

    With the drilling targets going increasingly deeper ,a new drilling parameters optimization method based on mechanical specific energy (MSE)theory was investigated to continually improve the rate of penetration in deep formations .From the perspectives of rock mechanics and conservation of energy ,the relationship between drilling parameters and ROP has been derived from comprehensive analysis of opti-mized drilling mechanism based on MSE .Based on the R .Teale MSE model ,by introducing the sliding fric-tion coefficient and rock-broken efficiency of the bit ,the torque was expressed as the function of drilling weight to solve the difficulty of measuring torque directly in conventional drilling ,the optimized models were built on the basis of specific energy theory for different drilling modes ,and a real-time drilling optimi-zation system was developed .The system can monitor all dynamic drilling parameters during drilling opera-tion ,and feed back the performance of drilling parameters and dow nhole situation in real time .A pilot test shows the average ROP increased by 20% to 30% compared with offset wells ,and prolonged the service life of bit .T he research results indicate that specific energy optimized drilling technique can optimize drill-ing parameters in real time ,w hich can be used to drilling design ,parameter optimization and analysis ,so as to raise the ROP in deep formations and reduce drilling cost .%为了进一步提高深部地层钻井速度,利用机械比能理论对复合钻井参数进行优化。从岩石力学和能量守恒角度出发,分析了基于机械比能理论的钻井优化机理,得出了钻进参数与机械钻速之间的相互关系。在T eale机械比能模型的基础上,引入钻头滑动摩擦系数和钻头破岩效率系数,将扭矩表示为钻压的函数,解决了常规钻井中扭矩难以直接测量的问题,建立了基于比能理论的复合钻井参数优化模型,并开发了钻井优化系

  4. Sphere-Enhanced Microwave Ablation (sMWA) Versus Bland Microwave Ablation (bMWA): Technical Parameters, Specific CT 3D Rendering and Histopathology

    Energy Technology Data Exchange (ETDEWEB)

    Gockner, T. L., E-mail: theresa.gockner@med.uni-heidelberg.de [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology (Germany); Zelzer, S., E-mail: s.zelzer@dkfz-heidelberg.de [German Cancer Research Center (dkfz), Medical and Biological Informatics (Germany); Mokry, T., E-mail: theresa.mokry@med.uni-heidelberg.de; Gnutzmann, D., E-mail: daniel.gnutzmann@med.uni-heidelberg.de; Bellemann, N., E-mail: nadine.bellemann@med.uni-heidelberg.de [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology (Germany); Mogler, C., E-mail: carolin.mogler@med.uni-heidelberg.de [University Hospital Heidelberg, Department of General Pathology (Germany); Beierfuß, A., E-mail: anja.beierfuss@ethianum.de; Köllensperger, E., E-mail: eva.koellensperger@ethianum.de; Germann, G., E-mail: guenter.germann@ethianum.de [Ethianum Heidelberg, Clinic for Plastic Reconstructive Surgery and Aesthetic Surgery (Germany); Radeleff, B. A., E-mail: boris.radeleff@med.uni-heidelberg.de; Stampfl, U., E-mail: ulrike.stampfl@med.uni-heidelberg.de; Kauczor, H. U., E-mail: hu.kauczor@med.uni-heidelberg.de [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology (Germany); Pereira, P. L., E-mail: philippe.pereira@slk-kliniken.de [SLK Kliniken Heilbronn GmbH, Clinic for Radiology, Minimally-invasive Therapies and Nuclear Medicine (Germany); Sommer, C. M., E-mail: christof.sommer@med.uni-heidelberg.de [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology (Germany)

    2015-04-15

    PurposeThis study was designed to compare technical parameters during ablation as well as CT 3D rendering and histopathology of the ablation zone between sphere-enhanced microwave ablation (sMWA) and bland microwave ablation (bMWA).MethodsIn six sheep-livers, 18 microwave ablations were performed with identical system presets (power output: 80 W, ablation time: 120 s). In three sheep, transarterial embolisation (TAE) was performed immediately before microwave ablation using spheres (diameter: 40 ± 10 μm) (sMWA). In the other three sheep, microwave ablation was performed without spheres embolisation (bMWA). Contrast-enhanced CT, sacrifice, and liver harvest followed immediately after microwave ablation. Study goals included technical parameters during ablation (resulting power output, ablation time), geometry of the ablation zone applying specific CT 3D rendering with a software prototype (short axis of the ablation zone, volume of the largest aligned ablation sphere within the ablation zone), and histopathology (hematoxylin-eosin, Masson Goldner and TUNEL).ResultsResulting power output/ablation times were 78.7 ± 1.0 W/120 ± 0.0 s for bMWA and 78.4 ± 1.0 W/120 ± 0.0 s for sMWA (n.s., respectively). Short axis/volume were 23.7 ± 3.7 mm/7.0 ± 2.4 cm{sup 3} for bMWA and 29.1 ± 3.4 mm/11.5 ± 3.9 cm{sup 3} for sMWA (P < 0.01, respectively). Histopathology confirmed the signs of coagulation necrosis as well as early and irreversible cell death for bMWA and sMWA. For sMWA, spheres were detected within, at the rim, and outside of the ablation zone without conspicuous features.ConclusionsSpecific CT 3D rendering identifies a larger ablation zone for sMWA compared with bMWA. The histopathological signs and the detectable amount of cell death are comparable for both groups. When comparing sMWA with bMWA, TAE has no effect on the technical parameters during ablation.

  5. Retrospective monitoring of minimal residual disease using hairpin-shaped clone specific primers in B-cell lymphoma affected dogs.

    Science.gov (United States)

    Gentilini, Fabio; Turba, Maria E; Forni, Monica

    2013-06-15

    Lymphoma is one of the most common forms of cancer in dogs as it is in humans but, unlike humans, the cure rates in canines are still very low. Despite the fact that high grade B-cell lymphomas are considered to be chemotherapy responsive, almost all treated dogs ultimately relapse and die due to the residual malignant lymphocytes, namely minimal residual disease (MRD). It would be extremely valuable for clinicians to detect, monitor and quantify MRD for risk group stratification, effective treatment intervention and outcome prediction. The PCRs targeting the Ig gene rearrangements constitute one of the most reliable tools to this end. We have recently validated a method which exploits hairpin-shaped primers for quantifying MRD. In the present study, that method is conveniently used for retrospectively monitoring MRD in the peripheral blood of 8 dogs diagnosed with B-cell lymphoma who underwent chemotherapy. All dogs attained complete remission. The median disease-free interval was 254.5 days (range 63-774) while the median survival time was 313.5 days (range 143-817 days). At admission, all dogs, except one which had already been treated with prednisone, had circulating neoplastic cells. All dogs attained complete remission (CR) which was almost always matched with a complete MRD response. The persistence of MRD despite apparent CR indicated a worse prognosis and a short duration of CR. Finally, the relapse is consistently anticipated by the reappearance of MRD in the peripheral blood. The study confirmed the suitability of an MRD monitoring assay as a clinical decision-making tool.

  6. Calibrating passive acoustic monitoring: correcting humpback whale call detections for site-specific and time-dependent environmental characteristics.

    Science.gov (United States)

    Helble, Tyler A; D'Spain, Gerald L; Campbell, Greg S; Hildebrand, John A

    2013-11-01

    This paper demonstrates the importance of accounting for environmental effects on passive underwater acoustic monitoring results. The situation considered is the reduction in shipping off the California coast between 2008-2010 due to the recession and environmental legislation. The resulting variations in ocean noise change the probability of detecting marine mammal vocalizations. An acoustic model was used to calculate the time-varying probability of detecting humpback whale vocalizations under best-guess environmental conditions and varying noise. The uncorrected call counts suggest a diel pattern and an increase in calling over a two-year period; the corrected call counts show minimal evidence of these features.

  7. Monitoring the efficacy of specific treatment in chronic Chagas disease by polymerase chain reaction and flow cytometry analysis

    OpenAIRE

    Sánchez G.; Coronado X.; Zulantay I.; Apt W.; Gajardo M.; Solari S.; Venegas J.

    2005-01-01

    PCR and FC-ALTA were used to monitor parasite clearance in 54 chronic chagasic patients who had completed therapy with allopurinol (ALLO, n = 31) or itraconazole (ITRA, n = 23) ten years earlier. All patients maintained positive conventional serology. 25 of them showed positive XD (ALLO, n = 11 and ITRA, n = 14) and 29 negative XD (ALLO, n = 20 and ITRA, n = 9). 43 patients were positive by both techniques (ALLO, n = 23 and ITRA, n = 20). Seven of 54 patients were negative by PCR and positive...

  8. Nailfold videocapillaroscopy in systemic sclerosis: diagnostic and follow-up parameters and correlation with both specific serum autoantibodies and subsets of skin involvement

    Directory of Open Access Journals (Sweden)

    B. Seriolo

    2011-09-01

    Full Text Available Introduction: The aim of the present study was to demonstrate, by nailfold videocapillaroscopy (NVC, the existence of diagnostic and follow-up parameters of microvascular damage in systemic sclerosis (SS (grouped in the “early”, “active” and “late” NVC patterns. The presence of the different subsets of skin involvement (limSS and difSS, as well as the role of some specific serum autoantibodies in the expression of the NVC parameters were investigated. Methods: 245 consecutive SS patients were recruited and clinical data assessed. Antinuclear (ANA, antitopoisomerase I (Scl70 and anticentromere (ACA antibodies were investigated in all patients. Results: Giant capillaries and hemorrhages were confirmed to be the earliest NVC finding in SS (diagnostic parameters. The loss of capillaries, along with ramified capillaries and vascular architectural disorganization were validated as parameters of progression of SS microangiopathy. Really, both Raynaud’s phenomenon (RP and SS duration were detected longer in patients with the “late” than in those with the “active” or the “early” NVC pattern. Patients affected by limSS were found to have shorter disease duration, as well as showed more frequently the “early” or the “active” NVC patterns. Conversely, patients affected by the difSS showed longer disease duration and mostly the presence of the “active” or “late” NVC pattern. The Scl70 positivity was lower in the patients showing the “early” than in those with the “active” and the “late” NVC patterns, whereas no significant correlation was found between the Scl70 presence and both RP and SS duration. The ACA positivity was higher in patients showing the “early” NVC pattern, as well as in patients with longer disease duration. Conclusions: This study confirms that the identification of distinct NVC patterns may be useful to evaluate the severity and the stage of the SS microvascular damage. The presence

  9. Influence of specific training on spatio-temporal parameters at the onset of goal-directed reaching in infants: a controlled trial

    Directory of Open Access Journals (Sweden)

    Andréa B. Cunha

    2013-07-01

    Full Text Available BACKGROUND: There is evidence that long-term experience can promote functional changes in infants. However, much remains unknown about how a short-term experience affects performance of a task. OBJECTIVE: This study aims to investigate the influence of a single training session at the onset of goal-directed reaching on the spatio-temporal parameters of reaching and whether there are differences in the effects of training across different reaching positions. METHOD: Thirty-three infants were divided into three groups: 1 a control group; 2 a group that was reach trained in a reclined position; and 3 a group trained in the supine position. The infants were submitted to two assessments (pre- and post-training in two testing positions (supine and reclined at 45°. RESULTS: The short-duration training sessions were effective in promoting shorter reaches in the specific position in which the training was conducted. Training in the reclined position was associated with shorter and faster reaches upon assessment in the reclined position. CONCLUSIONS: A few minutes of reach training are effective in facilitating reaching behavior in infants at the onset of reaching. The improvements in reaching were specific to the position in which the infants were trained.

  10. Inverse gas chromatography for natural fibre characterisation: Identification of the critical parameters to determine the Brunauer-Emmett-Teller specific surface area.

    Science.gov (United States)

    Legras, A; Kondor, A; Heitzmann, M T; Truss, R W

    2015-12-18

    Inverse gas chromatography (IGC) is an alternative technique to determine the specific surface area of natural fibres. Natural fibres have a complex surface chemistry and unique microstructure that challenge the current capabilities to perform surface characterisation. This study investigated the influence of multiple parameters on the measured Brunauer-Emmett-Teller (BET) specific surface area for samples of flax, kenaf and BioMid(®) cellulose fibres using IGC. The BET surface area of kenaf and flax differed with 0.51m(2)g(-1) and 1.35m(2)g(-1) respectively, the former being similar to the cellulose fibres (0.54m(2)g(-1)). The data was calculated under conditions where the BET equation showed good linearity (R(2)⩾0.995). Repeatability was excellent so that two runs sufficed to obtain representative BET surface area values. The findings showed the choice of solvent was important for all specimens to avoid any misleading data comparison due to molecular orientation effects that impact the adsorbent-adsorbate interactions. The higher surface area of the flax sample, and its higher variability, was correlated with a higher surface roughness observed under optical microscopy. Packing the chromatography column with long or chopped fibres produced results that were statistically insignificant.

  11. Fractionation in position-specific isotope composition during vaporization of environmental pollutants measured with isotope ratio monitoring by ¹³C nuclear magnetic resonance spectrometry.

    Science.gov (United States)

    Julien, Maxime; Parinet, Julien; Nun, Pierrick; Bayle, Kevin; Höhener, Patrick; Robins, Richard J; Remaud, Gérald S

    2015-10-01

    Isotopic fractionation of pollutants in terrestrial or aqueous environments is a well-recognized means by which to track different processes during remediation. As a complement to the common practice of measuring the change in isotope ratio for the whole molecule using isotope ratio monitoring by mass spectrometry (irm-MS), position-specific isotope analysis (PSIA) can provide further information that can be exploited to investigate source and remediation of soil and water pollutants. Position-specific fractionation originates from either degradative or partitioning processes. We show that isotope ratio monitoring by (13)C NMR (irm-(13)C NMR) spectrometry can be effectively applied to methyl tert-butylether, toluene, ethanol and trichloroethene to obtain this position-specific data for partitioning. It is found that each compound exhibits characteristic position-specific isotope fractionation patterns, and that these are modulated by the type of evaporative process occurring. Such data should help refine models of how remediation is taking place, hence back-tracking to identify pollutant sources.

  12. A modified method for diffusive monitoring of 3-ethenylpyridine as a specific marker of environmental tobacco smoke

    Science.gov (United States)

    Kuusimäki, Leea; Peltonen, Kimmo; Vainiotalo, Sinikka

    A previously introduced method for monitoring environmental tobacco smoke (ETS) was further validated. The method is based on diffusive sampling of a vapour-phase marker, 3-ethenylpyridine (3-EP), with 3 M passive monitors (type 3500). Experiments were done in a dynamic chamber to assess diffusive sampling in comparison with active sampling in charcoal tubes or XAD-4 tubes. The sampling rate for 3-EP collected on the diffusive sampler was 23.1±0.6 mL min -1. The relative standard deviation for parallel samples ( n=6) ranged from 4% to 14% among experiments ( n=9). No marked reverse diffusion of 3-EP was detected nor any significant effect of relative humidity at 20%, 50% or 80%. The diffusive sampling of 3-EP was validated in field measurements in 15 restaurants in comparison with 3-EP and nicotine measurements using active sampling. The 3-EP concentration in restaurants ranged from 0.01 to 9.8 μg m -3, and the uptake rate for 3-EP based on 92 parallel samples was 24.0±0.4 mL min -1. A linear correlation ( r=0.98) was observed between 3-EP and nicotine concentrations, the average ratio of 3-EP to nicotine being 1:8. Active sampling of 3-EP and nicotine in charcoal tubes provided more reliable results than sampling in XAD-4 tubes. All samples were analysed using gas chromatography-mass spectrometry after elution with a 15% solution of pyridine in toluene. For nicotine, the limit of quantification of the charcoal tube method was 4 ng per sample, corresponding to 0.04 μg m -3 for an air sample of 96 L. For 3-EP, the limit of quantification of the diffusive method was 0.5-1.0 ng per sample, corresponding to 0.04-0.09 μg m -3 for 8 h sampling. The diffusive method proved suitable for ETS monitoring, even at low levels of ETS.

  13. Parameters of the 24 Hours Ambulatory Blood Pressure Monitoring and the Significance%24 h动态血压各项指标及其意义

    Institute of Scientific and Technical Information of China (English)

    于佳岚

    2012-01-01

    动态血压监测帮助临床医师可以获知以下内容:血压变异性,与患者自主神经调节功能及压力反射的敏感性有关,可预测靶器官受损程度;晨峰血压,晨起交感神经兴奋性及体液调节异常造成血压急剧升高,达一定数值将对心、脑血管造成危害;实时血压数值,单纯收缩期高血压/脉压增大多见于老年高血压患者,在高血压治疗过程可能出现"J曲线效应",准确得到血压数值及正确用药将决定患者预后.%The ambulatory blood pressure monitoring( ABPM )is conducted to obtain the following parameters : blood pressure variability (BPV ), which is related to autonomic nervous system( ANS )and barore-flex sensitivity( BRS ), can be used to predict the severity of target organ damage; morning blood pressure surge( MBPS ): increased sympathetic tone and abnormally high body fluids cause blood pressure significantly elevating, which will damage the blood vessels of the brain and heart; real-time blood pressure: isolated systolic hypertension( 1S11 )/pulse pressure increases is particularly common in the elderly, J-curve phenomenon might appear in the treatment of hypertension. So an accurate blood pressure and a correct medication play an important role in the prognosis of hypertension patients.

  14. Monitoramento localizado da produtividade de milho cultivado sob irrigação Site-specific monitoring of corn yield cultivated under irrigation

    Directory of Open Access Journals (Sweden)

    Antonio O. Santos

    2001-04-01

    ,3 ha, irrigated by a center-pivot system, monitoring of maize yield was done in the growing season 99/00 besides the soil fertility parameter. Results showed different patterns of yield distribution inside the field, and the causes of observed yield variability. Preliminary analysis of soil data showed low correlation between yield and soil chemical properties in a site-specific base. Observation of yield data suggests the development of strategic management zones, based on trend analysis of the most influent yield components.

  15. Biological Monitoring at Buldir Island, Alaska in 2009

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The specific monitoring goals in 2009 were to estimate productivity and/or population parameters for 15 indicator species representing four major feeding guilds: 1)...

  16. Simulating Non-Specific Influences of Body Posture and Temperature on Thigh-Bioimpedance Spectroscopy during Continuous Monitoring Applications

    Science.gov (United States)

    Ismail, A. H.; Leonhardt, S.

    2013-04-01

    Application of bioimpedance spectroscopy (BIS) for continuous monitoring of body fluid volumes is gaining considerable importance in personal health care. Unless laboratory conditions are applied, both whole-body or segmental BIS configurations are subject to nonspecific influences (e.g. temperature and change in body position) reducing the method's accuracy and reproducibility. In this work, a two-compartment mathematical model, which describes the thigh segment, has been adapted to simulate fluid and solute kinetics during change in body position or variation in skin temperature. The model is an improved version of our previous one offering a good tradeoff between accuracy and simplicity. It represents the kinetics of fluid redistribution, sodium-, potassium-, and protein-concentrations based on simple equations to predict the time course of BIS variations. Validity of the model was verified in five subjects (following a sequence of 7 min supine, 20 min standing, and 40 min supine). The output of the model may reduce possible influences on BIS by up to 80%.

  17. Specific features of the radial distributions of plasma parameters in the initial segment of a supersonic jet generated by a pulsed capillary discharge

    Science.gov (United States)

    Pashchina, A. S.; Efimov, A. V.; Chinnov, V. F.; Ageev, A. G.

    2017-07-01

    Results are presented from spectroscopic studies of the initial segment of a supersonic plasma jet generated by a pulsed capillary discharge with an ablative carbon-containing polymer wall. Specific features of the spatial distributions of the electron density and intensities of spectral components caused, in particular, by the high electron temperature in the central zone, much exceeding the normal temperature, as well as by the high nonisobaricity of the initial segment of the supersonic jet, are revealed. Measurements of the radiative properties of the hot jet core (the intensity and profile of the Hα and Hβ Balmer lines and the relative intensities of C II lines) with high temporal (1-50 μs) and spatial (30-50 μm) resolutions made it possible to determine general features of the pressure and temperature distributions near the central shock. The presence of molecular components exhibiting their emission properties at the periphery of the plasma jet allowed the authors to estimate the parameters of the plasma in the jet region where "detached" shock waves form.

  18. Breast dose reduction for chest CT by modifying the scanning parameters based on the pre-scan size-specific dose estimate (SSDE)

    Energy Technology Data Exchange (ETDEWEB)

    Kidoh, Masafumi; Utsunomiya, Daisuke; Oda, Seitaro; Nakaura, Takeshi; Yuki, Hideaki; Hirata, Kenichiro; Namimoto, Tomohiro; Sakabe, Daisuke; Hatemura, Masahiro; Yamashita, Yasuyuki [Kumamoto University, Department of Diagnostic Radiology, Faculty of Life Sciences, Honjo, Kumamoto (Japan); Funama, Yoshinori [Kumamoto University, Department of Medical Physics, Faculty of Life Sciences, Honjo, Kumamoto (Japan)

    2017-06-15

    To investigate the usefulness of modifying scanning parameters based on the size-specific dose estimate (SSDE) for a breast-dose reduction for chest CT. We scanned 26 women with a fixed volume CT dose index (CTDI{sub vol}) (15 mGy) and another 26 with a fixed SSDE (15 mGy) protocol (protocol 1 and 2, respectively). In protocol 2, tube current was calculated based on the patient habitus obtained on scout images. We compared the mean breast dose and the inter-patient breast dose variability and performed linear regression analysis of the breast dose and the body mass index (BMI) of the two protocols. The mean breast dose was about 35 % lower under protocol 2 than protocol 1 (10.9 mGy vs. 16.8 mGy, p < 0.01). The inter-patient breast dose variability was significantly lower under protocol 2 than 1 (1.2 mGy vs. 2.5 mGy, p < 0.01). We observed a moderate negative correlation between the breast dose and the BMI under protocol 1 (r = 0.43, p < 0.01); there was no significant correlation (r = 0.06, p = 0.35) under protocol 2. The SSDE-based protocol achieved a reduction in breast dose and in inter-patient breast dose variability. (orig.)

  19. Computer-based design of an HLA-haplotype and HIV-clade independent cytotoxic T-lymphocyte assay for monitoring HIV-specific immunity.

    Science.gov (United States)

    Amicosante, Massimo; Gioia, Cristiana; Montesano, Carla; Casetti, Rita; Topino, Simone; D'Offizi, Gianpiero; Cappelli, Giulia; Ippolito, Giuseppe; Colizzi, Vittorio; Poccia, Fabrizio; Pucillo, Leopoldo P.

    2002-01-01

    BACKGROUND: Human immunodeficiency virus (HIV)- specific CD8-positive cytotoxic T-lymphocytes (CTL) play a key role in controlling HIV infection. Monitoring CTL response could be clinically relevant during structured therapy interruption (STI), HIV exposure, and vaccine trials. However, HLA patients' restriction and HIV variability limited the development of a CTL assay with broad specificity. MATERIALS AND METHODS: We designed an HLA-class I/HIV-1 clade independent assay for assessing HIV- specific CTL by using a computer-assisted selection ofthe CTL epitopes. Twenty-eight 15-mers were selected by peptide-binding motifs analysis using different databases (HIV-Immunology Database, SYFPEITHI, BIMAS). Altogether they putatively bind to more than 90% of HLA haplotypes in different populations, with an overall HIV-1 variability below 9%. The peptide pool was used as an antigen in an intracellular cytokine staining (ICS) assay for quantifying HIV-specific CTL response. RESULTS: The test can be performed using both fresh and cryopreserved peripheral blood mononuclear cells (PBMC), whereas GAG protein as antigen works only on fresh PBMC. A significantly higher CTL response with respect to HIV-negative controls was detected in all HIV-1 infected subjects of two groups of patients with different ethnicities (Caucasians and Africans) and coming from areas with different HIV-1 clade prevalences (clade B and A/G, respectively). In Caucasian patients, after month of STI, the number of HIV-1 specific CTL (2,896 +/- 2,780 IFN-gamma specific CD8 cells/ml) was significantly higher than that found at enrolment (2,125 +/- 4,426 IFN-gamma specific CD8 cells/ml, p< 0.05). CONCLUSIONS: These data indicate that this CTL assay is broadly specific and could represent a useful clinical tool for HIV immunodiagnostic independent of HLA-haplotype and HIV-clade variabilities. PMID:12606814

  20. Specimen specific parameter identification of ovine lumbar intervertebral discs: On the influence of fibre-matrix and fibre-fibre shear interactions.

    Science.gov (United States)

    Reutlinger, Christoph; Bürki, Alexander; Brandejsky, Vaclav; Ebert, Lars; Büchler, Philippe

    2014-02-01

    Numerical models of the intervertebral disc, which address mechanical questions commonly make use of the difference in water content between annulus and nucleus, and thus fluid and solid parts are separated. Despite this simplification, models remain complex due to the anisotropy and nonlinearity of the annulus and regional variations of the collagen fibre density. Additionally, it has been shown that cross-links make a large contribution to the stiffness of the annulus. Because of this complex composite structure, it is difficult to reproduce several sets of experimental data with one single set of material parameters. This study addresses the question to which extent the ultrastructure of the intervertebral disc should be modelled so that its moment-angle behaviour can be adequately described. Therefore, a hyperelastic constitutive law, based on continuum mechanical principles was derived, which does not only consider the anisotropy from the collagen fibres, but also interactions among the fibres and between the fibres and the ground substance. Eight ovine lumbar intervertebral discs were tested on a custom made spinal loading simulator in flexion/extension, lateral bending and axial rotation. Specimen-specific geometrical models were generated using CT images and T2 maps to distinguish between annulus fibrosus and nucleus pulposus. For the identification of the material parameters the annulus fibrosus was described with two scenarios: with and without fibre-matrix and fibre-fibre interactions. Both scenarios showed a similar behaviour on a load displacement level. Comparing model predictions to the experimental data, the mean RMS of all specimens and all load cases was 0.54±0.15° without the interaction and 0.54±0.19° when the fibre-matrix and fibre-fibre interactions were included. However, due to the increased stiffness when cross-links effects were included, this scenario showed more physiological stress-strain relations in uniaxial and biaxial stress

  1. Post-transplant donor-specific antibody production and graft outcome in kidney transplantation: results of sixteen-year monitoring by flow cytometry.

    Science.gov (United States)

    Piazza, Antonina; Poggi, Elvira; Ozzella, Giuseppina; Borrelli, Laura; Scornajenghi, Alessandra; Iaria, Giuseppe; Tisone, Giuseppe; Adorno, Domenico

    2006-01-01

    Our data show that monitoring by sensitive flow cytometric techniques of the de novo production of anti-HLA antibodies in patients receiving kidney transplantation is a useful and noninvasive tool to identify the onset of an immune response towards the graft before any clinical manifestation of antibody-mediated graft injury. Consequently prospective posttransplant monitoring of anti-HLA donor-directed antibodies may offer the chance to realize an effective clinical intervention in order to prevent graft dysfunction and to prolong graft survival. The long follow-up period of the study allowed us to demonstrate a very low graft survival rate in patients who developed donor-specific HLA antibodies in comparison with patients who did not have antibodies, thus confirming the "humoral theory of transplantation". The posttransplant production of anti-HLA antibodies can predict not only graft failure but also chronic dysfunction of the graft. Moreover, our findings suggest that graft survival is influenced by the epitope- and locus-specificity of anti-HLA donor-directed antibodies. The interval between antibody appearance and loss of graft function was short in some patients but reached several years in others. Moreover, some patients showed consistent production of antibodies for many years and an uneventful clinical status. These findings suggest a mechanism of graft "accommodation" or the production of "harmless" antibodies. Immunosuppressive drug combinations able to inhibit T and B cell activation are useful tools to prevent the humoral immune response against graft and consequently to prolong graft survival.

  2. A microfluidic device for real-time monitoring of Bacillus subtilis bacterial spores during germination based on non-specific physicochemical interactions on the nanoscale level.

    Science.gov (United States)

    Zabrocka, L; Langer, K; Michalski, A; Kocik, J; Langer, J J

    2015-01-07

    A microfluidic device for studies on the germination of bacterial spores (e.g. Bacillus subtilis) based on non-specific interactions on the nanoscale is presented. A decrease in the population of spores during germination followed by the appearance of transition forms and an increase in the number of vegetative cells can be registered directly and simultaneously by using the microfluidic device, which is equipped with a conductive polymer layer (polyaniline) in the form of a nano-network. The lab-on-a-chip-type device, operating in a continuous flow regime, allows monitoring of germination of bacterial spores and analysis of the process in detail. The procedure is fast and accurate enough for quantitative real-time monitoring of the main steps of germination, including final transformation of the spores into vegetative cells. All of this is done without the use of biomarkers or any bio-specific materials, such as enzymes, antibodies and aptamers, and is simply based on an analysis of physicochemical interactions on the nanoscale level.

  3. HLA micropolymorphisms strongly affect peptide-MHC multimer-based monitoring of antigen-specific CD8+ T cell responses.

    Science.gov (United States)

    van Buuren, Marit M; Dijkgraaf, Feline E; Linnemann, Carsten; Toebes, Mireille; Chang, Cynthia X L; Mok, Juk Yee; Nguyen, Melanie; van Esch, Wim J E; Kvistborg, Pia; Grotenbreg, Gijsbert M; Schumacher, Ton N M

    2014-01-15

    Peptide-MHC (pMHC) multimers have become one of the most widely used tools to measure Ag-specific T cell responses in humans. With the aim of understanding the requirements for pMHC-based personalized immunomonitoring, in which individuals expressing subtypes of the commonly studied HLA alleles are encountered, we assessed how the ability to detect Ag-specific T cells for a given peptide is affected by micropolymorphic differences between HLA subtypes. First, analysis of a set of 10 HLA-A*02:01-restricted T cell clones demonstrated that staining with pMHC multimers of seven distinct subtypes of the HLA-A*02 allele group was highly variable and not predicted by sequence homology. Second, to analyze the effect of minor sequence variation in a clinical setting, we screened tumor-infiltrating lymphocytes of an HLA-A*02:06 melanoma patient with either subtype-matched or HLA-A*02:01 multimers loaded with 145 different melanoma-associated Ags. This revealed that of the four HLA-A*02:06-restricted melanoma-associated T cell responses observed in this patient, two responses were underestimated and one was overlooked when using subtype-mismatched pMHC multimer collections. To our knowledge, these data provide the first demonstration of the strong effect of minor sequence variation on pMHC-based personalized immunomonitoring, and they provide tools to prevent this issue for common variants within the HLA-A*02 allele group.

  4. Micro-PET/CT Monitoring of Herpes Thymidine Kinase Suicide Gene Therapy in a Prostate Cancer Xenograft: The Advantage of a Cell-specific Transcriptional Targeting Approach

    Directory of Open Access Journals (Sweden)

    Mai Johnson

    2005-10-01

    Full Text Available Cancer gene therapy based on tissue-restricted expression of cytotoxic gene should achieve superior therapeutic index over an unrestricted method. This study compared the therapeutic effects of a highly augmented, prostate-specific gene expression method to a strong constitutive promoter-driven approach. Molecular imaging was coupled to gene therapy to ascertain real-time therapeutic activity. The imaging reporter gene (luciferase and the cytotoxic gene (herpes simplex thymidine kinase were delivered by adenoviral vectors injected directly into human prostate tumors grafted in SCID mice. Serial bioluminescence imaging, positron emission tomography, and computed tomography revealed restriction of gene expression to the tumors when prostate-specific vector was employed. In contrast, administration of constitutive active vector resulted in strong signals in the liver. Liver serology, tissue histology, and frail condition of animals confirmed liver toxicity suffered by the constitutive active cohorts, whereas the prostate-targeted group was unaffected. The extent of tumor killing was analyzed by apoptotic staining and human prostate marker (prostate-specific antigen. Overall, the augmented prostate-specific expression system was superior to the constitutive approach in safeguarding against systemic toxicity, while achieving effective tumor killing. Integrating noninvasive imaging into cytotoxic gene therapy will provide a useful strategy to monitor gene expression and therapeutic efficacy in future clinical protocols.

  5. Development of Site-Specific Mg(2+)-RNA Force Field Parameters: A Dream or Reality? Guidelines from Combined Molecular Dynamics and Quantum Mechanics Simulations.

    Science.gov (United States)

    Casalino, Lorenzo; Palermo, Giulia; Abdurakhmonova, Nodira; Rothlisberger, Ursula; Magistrato, Alessandra

    2017-01-10

    The vital contribution of Mg(2+) ions to RNA biology is challenging to dissect at the experimental level. This calls for the integrative support of atomistic simulations, which at the classical level are plagued by limited accuracy. Indeed, force fields intrinsically neglect nontrivial electronic effects that Mg(2+) exerts on its surrounding ligands in varying RNA coordination environments. Here, we present a combined computational study based on classical molecular dynamics (MD) and Density Functional Theory (DFT) calculations, aimed at characterizing (i) the performance of five Mg(2+) force field (FF) models in RNA systems and (ii) how charge transfer and polarization affect the binding of Mg(2+) ions in different coordination motifs. As a result, a total of ∼2.5 μs MD simulations (100/200 ns for each run) for two prototypical Mg(2+)-dependent ribozymes showed remarkable differences in terms of populations of inner-sphere coordination site types. Most importantly, complementary DFT calculations unveiled that differences in charge transfer and polarization among recurrent Mg(2+)-RNA coordination motifs are surprisingly small. In particular, the charge of the Mg(2+) ions substantially remains constant through different coordination sites, suggesting that the common philosophy of developing site-specific Mg(2+) ion parameters is not in line with the physical origin of the Mg(2+)-RNA MD simulations inaccuracies. Overall, this study constitutes a guideline for an adept use of current Mg(2+) models and provides novel insights for the rational development of next-generation Mg(2+) FFs to be employed for atomistic simulations of RNA.

  6. Opportunistic prostate-specific antigen screening in Italy: 6 years of monitoring from the Italian general practice database.

    Science.gov (United States)

    D'Ambrosio, Gaetano Giorgio; Campo, Salvatore; Cancian, Maurizio; Pecchioli, Serena; Mazzaglia, Giampiero

    2010-11-01

    The practice of prostate-specific antigen (PSA) screening has been increasing in Italy despite uncertain scientific evidence and contrary recommendations from most scientific societies. In 2002, a survey of PSA screening diffusion among general practices was performed, looking for screening frequency and age pattern of screened individuals. The objective of this study was to assess whether the features of PSA screening did change after 6 years in the same considered setting. Using the data obtained from 500 Italian general practitioners providing information to the Health Search/CSD Patient database, we selected, for the study purpose 351,091 male individuals. We assumed PSA prescriptions performed during 2005-2008 in individuals without prostate cancer, or benign prostate disease, or urological symptoms history to have a screening purpose. Screening frequency was analyzed in the overall series, by year and by patient's age. Exposure to PSA screening (at least on PSA test in the considered period) of males aged over 50 years raised from 31.4% (confidence interval 95% 31.08-31.70%) during 2002 to 46.4% (confidence interval 95% 46.19-46.68%) during 2008. The highest yearly exposure to PSA screening (55%) and the highest frequency of repeat testing was observed in the 70-79 age range. PSA screening practice has continued to increase in Italy and is often performed in elderly people without any scientific rationale.

  7. Towards Detecting Swath Events in TerraSAR-X Time Series to Establish NATURA 2000 Grassland Habitat Swath Management as Monitoring Parameter

    OpenAIRE

    Iftikhar Ali; Peter Lohmann; Annett Frick; Michael Förster; Birgit Kleinschmit; Christian Schuster

    2011-01-01

    Spatial monitoring tools are necessary to respond to the threat of global biodiversity loss. At the European scale, remote sensing tools for NATURA 2000 habitat monitoring have been requested by the European Commission to fulfill the obligations of the EU Habitats Directive. This paper introduces a method by which swath events in semi-natural grasslands can be detected from multi-temporal TerraSAR-X data. The investigated study sites represent rare and endangered habitats (NATURA 2000 codes 6...

  8. Control system and environmental parameters monitoring of the Tandetron Accelerator clean room; Sistema de control y monitoreo de parametros ambientales del cuarto limpio del acelerador Tandetron

    Energy Technology Data Exchange (ETDEWEB)

    Mejia V, M.E.; Garcia H, J.M.; Flores M, J. [ININ, Departamento de Sistemas Electronicos, 52750 La Marquesa, Estado de Mexico (Mexico)]. e-mail: mmejia@nuclear.inin.mx

    2007-07-01

    A control system and monitoring of humidity and temperature implemented by means of a system based on a microcontroller, an intelligent sensor and a stage of power for the actuators handling is described. The change of the levels of reference of the control system and the monitoring of the physical controlled variables can be carried out from any connected computer to a local net or Internet. (Author)

  9. Monitoring biodegradation of ethene and bioremediation of chlorinated ethenes at a contaminated site using compound-specific isotope analysis (CSIA)

    Science.gov (United States)

    Mundle, S.O.C.; Johnson, T.; Lacrampe-Couloume, G.; Perez-De-Mora, A.; Duhamel, M.; Edwards, E.A.; McMaster, M.L.; Cox, E.; Revesz, K.; Lollar, B. Sherwood

    2012-01-01

    Chlorinated ethenes are commonly found in contaminated groundwater. Remediation strategies focus on transformation processes that will ultimately lead to nontoxic products. A major concern with these strategies is the possibility of incomplete dechlorination and accumulation of toxic daughter products (cis-1,2-dichloroethene (cDCE), vinyl chloride (VC)). Ethene mass balance can be used as a direct indicator to assess the effectiveness of dechlorination. However, the microbial processes that affect ethene are not well characterized and poor mass balance may reflect biotransformation of ethene rather than incomplete dechlorination. Microbial degradation of ethene is commonly observed in aerobic systems but fewer cases have been reported in anaerobic systems. Limited information is available on the isotope enrichment factors associated with these processes. Using compound-specific isotope analysis (CSIA) we determined the enrichment factors associated with microbial degradation of ethene in anaerobic microcosms (ε = −6.7‰ ± 0.4‰, and −4.0‰ ± 0.8‰) from cultures collected from the Twin Lakes wetland area at the Savannah River site in Georgia (United States), and in aerobic microcosms (ε = −3.0‰ ± 0.3‰) from Mycobacterium sp. strain JS60. Under anaerobic and aerobic conditions, CSIA can be used to determine whether biotransformation of ethene is occurring in addition to biodegradation of the chlorinated ethenes. Using δ13C values determined for ethene and for chlorinated ethenes at a contaminated field site undergoing bioremediation, this study demonstrates how CSIA of ethene can be used to reduce uncertainty and risk at a site by distinguishing between actual mass balance deficits during reductive dechlorination and apparent lack of mass balance that is related to biotransformation of ethene.

  10. Monitoring biodegradation of ethene and bioremediation of chlorinated ethenes at a contaminated site using compound-specific isotope analysis (CSIA).

    Science.gov (United States)

    Mundle, Scott O C; Johnson, Tiffany; Lacrampe-Couloume, Georges; Pérez-de-Mora, Alfredo; Duhamel, Melanie; Edwards, Elizabeth A; McMaster, Michaye L; Cox, Evan; Révész, Kinga; Sherwood Lollar, Barbara

    2012-02-07

    Chlorinated ethenes are commonly found in contaminated groundwater. Remediation strategies focus on transformation processes that will ultimately lead to nontoxic products. A major concern with these strategies is the possibility of incomplete dechlorination and accumulation of toxic daughter products (cis-1,2-dichloroethene (cDCE), vinyl chloride (VC)). Ethene mass balance can be used as a direct indicator to assess the effectiveness of dechlorination. However, the microbial processes that affect ethene are not well characterized and poor mass balance may reflect biotransformation of ethene rather than incomplete dechlorination. Microbial degradation of ethene is commonly observed in aerobic systems but fewer cases have been reported in anaerobic systems. Limited information is available on the isotope enrichment factors associated with these processes. Using compound-specific isotope analysis (CSIA) we determined the enrichment factors associated with microbial degradation of ethene in anaerobic microcosms (ε = -6.7‰ ± 0.4‰, and -4.0‰ ± 0.8‰) from cultures collected from the Twin Lakes wetland area at the Savannah River site in Georgia (United States), and in aerobic microcosms (ε = -3.0‰ ± 0.3‰) from Mycobacterium sp. strain JS60. Under anaerobic and aerobic conditions, CSIA can be used to determine whether biotransformation of ethene is occurring in addition to biodegradation of the chlorinated ethenes. Using δ(13)C values determined for ethene and for chlorinated ethenes at a contaminated field site undergoing bioremediation, this study demonstrates how CSIA of ethene can be used to reduce uncertainty and risk at a site by distinguishing between actual mass balance deficits during reductive dechlorination and apparent lack of mass balance that is related to biotransformation of ethene.

  11. Monitoring of transplanted liver health by quantification of organ-specific genomic marker in circulating DNA from receptor.

    Directory of Open Access Journals (Sweden)

    Hada C Macher

    Full Text Available BACKGROUND: Health assessment of the transplanted organ is very important due to the relationship of long-term survival of organ transplant recipients and health organ maintenance. Nowadays, the measurement of cell-free DNA from grafts in the circulation of transplant recipients has been considered a potential biomarker of organ rejection or transplant associated complications in an attempt to replace or reduce liver biopsy. However, methods developed to date are expensive and extremely time-consuming. Our approach was to measure the SRY gene, as a male organ biomarker, in a setting of sex-mismatched female recipients of male donor organs. METHODS: Cell-free DNA quantization of the SRY gene was performed by real-time quantitative PCR beforehand, at the moment of transplantation during reperfusion (day 0 and during the stay at the intensive care unit. Beta-globin cell-free DNA levels, a general cellular damage marker, were also quantified. RESULTS: Beta-globin mean values of patients, who accepted the graft without any complications during the first week after surgery, diminished from day 0 until patient stabilization. This decrease was not so evident in patients who suffered some kind of post-transplantation complications. All patients showed an increase in SRY levels at day 0, which decreased during hospitalization. Different complications that did not compromise donated organs showed increased beta-globin levels but no SRY gene levels. However, when a donated organ was damaged the patients exhibited high levels of both genes. CONCLUSION: Determination of a SRY gene in a female recipient's serum is a clear and specific biomarker of donated organs and may give us important information about graft health in a short period of time by a non-expensive technique. This approach may permit clinicians to maintain a close follow up of the transplanted patient.

  12. Monitoring of Transplanted Liver Health by Quantification of Organ-Specific Genomic Marker in Circulating DNA from Receptor

    Science.gov (United States)

    Macher, Hada C.; Suárez-Artacho, Gonzalo; Guerrero, Juan M.; Gómez-Bravo, Miguel A.; Álvarez-Gómez, Sara; Bernal-Bellido, Carmen; Dominguez-Pascual, Inmaculada; Rubio, Amalia

    2014-01-01

    Background Health assessment of the transplanted organ is very important due to the relationship of long-term survival of organ transplant recipients and health organ maintenance. Nowadays, the measurement of cell-free DNA from grafts in the circulation of transplant recipients has been considered a potential biomarker of organ rejection or transplant associated complications in an attempt to replace or reduce liver biopsy. However, methods developed to date are expensive and extremely time-consuming. Our approach was to measure the SRY gene, as a male organ biomarker, in a setting of sex-mismatched female recipients of male donor organs. Methods Cell-free DNA quantization of the SRY gene was performed by real-time quantitative PCR beforehand, at the moment of transplantation during reperfusion (day 0) and during the stay at the intensive care unit. Beta-globin cell-free DNA levels, a general cellular damage marker, were also quantified. Results Beta-globin mean values of patients, who accepted the graft without any complications during the first week after surgery, diminished from day 0 until patient stabilization. This decrease was not so evident in patients who suffered some kind of post-transplantation complications. All patients showed an increase in SRY levels at day 0, which decreased during hospitalization. Different complications that did not compromise donated organs showed increased beta-globin levels but no SRY gene levels. However, when a donated organ was damaged the patients exhibited high levels of both genes. Conclusion Determination of a SRY gene in a female recipient's serum is a clear and specific biomarker of donated organs and may give us important information about graft health in a short period of time by a non-expensive technique. This approach may permit clinicians to maintain a close follow up of the transplanted patient. PMID:25489845

  13. [Evaluation of relevance in concussion and damage of health by monitoring of neuron specific enolase and S-100b protein].

    Science.gov (United States)

    Vajtr, D; Průsa, R; Kukacka, J; Houst'ava, L; Sámal, F; Pelichovská, M; Strejc, P; Toupalík, P

    2007-07-01

    Proteins released to the circulation from affected glial (neuron specific enolasis, NSE) or ganglial cells (S-100b protein) during traumatic brain injury might be used in diagnosis of traumatic brain injury in cases with negative finding on computer tomography scan (concussion) or in patients where the serious clinical status does not corresponde with mild changes on CT scan (diffuse axonal injury, DAI). Classification of DAI according Gennarelli considered the concussion as lower degree of DAI. 15 patients were divided into group I of mild conccussion (n=3) with 1-day duration of hospitalisation, group II of serious concussion (n=4) with more days duration of hospitalisation with negative findings on CT scan and group III of patients with diagnosis of DAI (n=8). Blood samples were investigated by immunoanalysis for NSE and protein S-100b (Elecsys 2010, Roche). Values of NSE (16.30 +/- 2.33 vs. 110.48 +/- 34.99 vs. 24.07 +/- 6.29 microg/l), and protein S-100b (0.207 +/- 0.03 vs. 0.945 +/- 0.69 vs. 0.736 +/- 0.36 microg/l) overdrow the reference value in cases of group I, II, and III. We discuss the biomechanics of trauma and the blood brain barrier damage in comparison with values of NSE and S-100b protein. [corrected] We proved the significantly higher values of the NSE in group of serious concussion compared to group of DAI. We demonstrated that concussions in some cases lead to serious damage of health.

  14. Does a single gait training session performed either overground or on a treadmill induce specific short-term effects on gait parameters in patients with hemiparesis? A randomized controlled study.

    Science.gov (United States)

    Bonnyaud, Céline; Pradon, Didier; Zory, Raphael; Bensmail, Djamel; Vuillerme, Nicolas; Roche, Nicolas

    2013-01-01

    Gait training for patients with hemiparesis is carried out independently overground or on a treadmill. Several studies have shown differences in hemiparetic gait parameters during overground versus treadmill walking. However, few studies have compared the effects of these 2 gait training conditions on gait parameters, and no study has compared the short-term effects of these techniques on all biomechanical gait parameters. To determine whether a gait training session performed overground or on a treadmill induces specific short-term effects on biomechanical gait parameters in patients with hemiparesis. Twenty-six subjects with hemiparesis were randomly assigned to a single session of either overground or treadmill gait training. The short-term effects on spatiotemporal, kinematic, and kinetic gait parameters were assessed using gait analysis before and immediately after the training and after a 20-minute rest. Speed, cadence, percentage of single support phase, peak knee extension, peak propulsion, and braking on the paretic side were significantly increased after the gait training session. However, there were no specific changes dependent on the type of gait training performed (overground or on a treadmill). A gait training session performed by subjects with hemiparesis overground or on a treadmill did not induce specific short-term effects on biomechanical gait parameters. The increase in gait velocity that followed a gait training session seemed to reflect specific modifications of the paretic lower limb and adaptation of the nonparetic lower limb.

  15. Adaptability analysis of the drought monitoring model based on the cloud parameters method in Africa%云参数法干旱遥感监测模型在非洲地区的适应性研究

    Institute of Scientific and Technical Information of China (English)

    张穗; 向大享; 孙忠华

    2013-01-01

    Firstly,the drought monitoring model based on CPI(Cloud Parameters Method/Index) is briefly introduced.Meanwhile,the characteristics of sensors,Spinning Enhanced Visible and Infra-Red Imager (SEVIRI),key payload of METAOSAT,are analyzed from the aspect for drought monitoring.Secondly,a suitable multi-spectral model is promoted to detect cloud pixels to calculate three cloud parameters.Then,the drought conditions of Africa in the winter of 2009 and spring of 2010 are monitored by using the cloud parameters method.Finally,the monitoring result is evaluated by comparing the monthly evaporation and monthly precipitation data from Climate Prediction Center,National Weather Service,US as reference data.The analysis indicated that the degree and scope of draught is almost same by comparing the monitoring results of CPI and area the reference data.Consequently,CPI is adaptable for the drought detecting in Africa.%从云参数法干旱遥感监测模型的需求角度分析了欧洲静止气象卫星SEVIRI数据的应用潜力,并提出了一种适合该数据的多光谱云检测方法;利用云参数法干旱遥感监测模型进行非洲地区2009年底和2010年初的干旱监测,以月度降水和蒸散数据作为参考数据评估监测结果.研究结果表明:云参数法监测结果与参考数据在干旱程度与范围方面基本一致,相对精度高达83.88%,云参数法适合进行非洲地区的干旱监测.

  16. Optimization of the most important operational parameters of a pneumatic seeder using real-time monitoring for Cucumber and Watermelon seeds

    Directory of Open Access Journals (Sweden)

    Z Abdolahzare

    2016-04-01

    Full Text Available Introduction: Since the application of pneumatic planters for seeds with different physical properties is growing, it is essential to evaluation the performance of these machines to improve the operating parameters under different pressures and forward speeds. To evaluate the performance of precision vacuum seeders numerous procedures of laboratory and field have been developed and their feed mechanism evaluation is of great importance. The use of instrumentation is essential in laboratory procedures. Many systems have been designed, using instrumentation, to be able to monitor seed falling trajectory and as a result, in those systems the precise place of falling seed in the seed bed could be determined. In this study, the uniformity of seed spacing of a seed drill was determined using of high speed camera with a frame rate of 480 frames s-1. So that, the uniformity of planting was statistically significant under the influence of the speed of seed metering rollers (Karayel et al., 2006. Singh et al. (2005 studied the effects of disk rotation speed, vacuum pressure and shape of seed entrance hole on planting spacing uniformity using uniformity indices under laboratory and field conditions. They reported miss index values were reduced as the pressure was increased but they were increased with increasing of the speed. The multiple indices on the other hand were low at higher speed but they were increased as the pressure was increased. Ground speed was affected by changes in engine speed and gear selection, both of which effect on amount of fan rotation speed for different pressures. The aim of this study was to identify and determine the effects of forward speed and optimum vacuum pressure amount of the pneumatic seeder. Materials and Methods: The pneumatic planter (Unissem was mounted on a tractor (MF399 and passed over the soil bin. Thus, the acquired data would be more reliable and practical. To do so, the tractor was equipped with electronic

  17. Comparison between In-house developed and Diamond commercial software for patient specific independent monitor unit calculation and verification with heterogeneity corrections.

    Science.gov (United States)

    Kuppusamy, Vijayalakshmi; Nagarajan, Vivekanandan; Jeevanandam, Prakash; Murugan, Lavanya

    2016-02-01

    The study was aimed to compare two different monitor unit (MU) or dose verification software in volumetric modulated arc therapy (VMAT) using modified Clarkson's integration technique for 6 MV photons beams. In-house Excel Spreadsheet based monitor unit verification calculation (MUVC) program and PTW's DIAMOND secondary check software (SCS), version-6 were used as a secondary check to verify the monitor unit (MU) or dose calculated by treatment planning system (TPS). In this study 180 patients were grouped into 61 head and neck, 39 thorax and 80 pelvic sites. Verification plans are created using PTW OCTAVIUS-4D phantom and also measured using 729 detector chamber and array with isocentre as the suitable point of measurement for each field. In the analysis of 154 clinically approved VMAT plans with isocentre at a region above -350 HU, using heterogeneity corrections, In-house Spreadsheet based MUVC program and Diamond SCS showed good agreement TPS. The overall percentage average deviations for all sites were (-0.93% + 1.59%) and (1.37% + 2.72%) for In-house Excel Spreadsheet based MUVC program and Diamond SCS respectively. For 26 clinically approved VMAT plans with isocentre at a region below -350 HU showed higher variations for both In-house Spreadsheet based MUVC program and Diamond SCS. It can be concluded that for patient specific quality assurance (QA), the In-house Excel Spreadsheet based MUVC program and Diamond SCS can be used as a simple and fast accompanying to measurement based verification for plans with isocentre at a region above -350 HU.

  18. Dose Adjustment Strategy of Cyclosporine A in Renal Transplant Patients: Evaluation of Anthropometric Parameters for Dose Adjustment and C0 vs. C2 Monitoring in Japan, 2001-2010

    Science.gov (United States)

    Kokuhu, Takatoshi; Fukushima, Keizo; Ushigome, Hidetaka; Yoshimura, Norio; Sugioka, Nobuyuki

    2013-01-01

    The optimal use and monitoring of cyclosporine A (CyA) have remained unclear and the current strategy of CyA treatment requires frequent dose adjustment following an empirical initial dosage adjusted for total body weight (TBW). The primary aim of this study was to evaluate age and anthropometric parameters as predictors for dose adjustment of CyA; and the secondary aim was to compare the usefulness of the concentration at predose (C0) and 2-hour postdose (C2) monitoring. An open-label, non-randomized, retrospective study was performed in 81 renal transplant patients in Japan during 2001-2010. The relationships between the area under the blood concentration-time curve (AUC0-9) of CyA and its C0 or C2 level were assessed with a linear regression analysis model. In addition to age, 7 anthropometric parameters were tested as predictors for AUC0-9 of CyA: TBW, height (HT), body mass index (BMI), body surface area (BSA), ideal body weight (IBW), lean body weight (LBW), and fat free mass (FFM). Correlations between AUC0-9 of CyA and these parameters were also analyzed with a linear regression model. The rank order of the correlation coefficient was C0 > C2 (C0; r=0.6273, C2; r=0.5562). The linear regression analyses between AUC0-9 of CyA and candidate parameters indicated their potential usefulness from the following rank order: IBW > FFM > HT > BSA > LBW > TBW > BMI > Age. In conclusion, after oral administration, C2 monitoring has a large variation and could be at high risk for overdosing. Therefore, after oral dosing of CyA, it was not considered to be a useful approach for single monitoring, but should rather be used with C0 monitoring. The regression analyses between AUC0-9 of CyA and anthropometric parameters indicated that IBW was potentially the superior predictor for dose adjustment of CyA in an empiric strategy using TBW (IBW; r=0.5181, TBW; r=0.3192); however, this finding seems to lack the pharmacokinetic rationale and thus warrants further basic and clinical

  19. PARAMETER COORDINATION AND ROBUST OPTIMIZATION FOR MULTIDISCIPLINARY DESIGN

    Institute of Scientific and Technical Information of China (English)

    HU Jie; PENG Yinghong; XIONG Guangleng

    2006-01-01

    A new parameter coordination and robust optimization approach for multidisciplinary design is presented. Firstly, the constraints network model is established to support engineering change, coordination and optimization. In this model, interval boxes are adopted to describe the uncertainty of design parameters quantitatively to enhance the design robustness. Secondly, the parameter coordination method is presented to solve the constraints network model, monitor the potential conflicts due to engineering changes, and obtain the consistency solution space corresponding to the given product specifications. Finally, the robust parameter optimization model is established, and genetic arithmetic is used to obtain the robust optimization parameter. An example of bogie design is analyzed to show the scheme to be effective.

  20. Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence.

    Science.gov (United States)

    Vo, Uybach; Vajpai, Navratna; Flavell, Liz; Bobby, Romel; Breeze, Alexander L; Embrey, Kevin J; Golovanov, Alexander P

    2016-01-22

    The activity of Ras is controlled by the interconversion between GTP- and GDP-bound forms partly regulated by the binding of the guanine nucleotide exchange factor Son of Sevenless (Sos). The details of Sos binding, leading to nucleotide exchange and subsequent dissociation of the complex, are not completely understood. Here, we used uniformly (15)N-labeled Ras as well as [(13)C]methyl-Met,Ile-labeled Sos for observing site-specific details of Ras-Sos interactions in solution. Binding of various forms of Ras (loaded with GDP and mimics of GTP or nucleotide-free) at the allosteric and catalytic sites of Sos was comprehensively characterized by monitoring signal perturbations in the NMR spectra. The overall affinity of binding between these protein variants as well as their selected functional mutants was also investigated using intrinsic fluorescence. The data support a positive feedback activation of Sos by Ras·GTP with Ras·GTP binding as a substrate for the catalytic site of activated Sos more weakly than Ras·GDP, suggesting that Sos should actively promote unidirectional GDP → GTP exchange on Ras in preference of passive homonucleotide exchange. Ras·GDP weakly binds to the catalytic but not to the allosteric site of Sos. This confirms that Ras·GDP cannot properly activate Sos at the allosteric site. The novel site-specific assay described may be useful for design of drugs aimed at perturbing Ras-Sos interactions.

  1. Adjusting the specificity of an engine map based on the sensitivity of an engine control parameter relative to a performance variable

    Science.gov (United States)

    Jiang, Li; Lee, Donghoon; Yilmaz, Hakan; Stefanopoulou, Anna

    2014-10-28

    Methods and systems for engine control optimization are provided. A first and a second operating condition of a vehicle engine are detected. An initial value is identified for a first and a second engine control parameter corresponding to a combination of the detected operating conditions according to a first and a second engine map look-up table. The initial values for the engine control parameters are adjusted based on a detected engine performance variable to cause the engine performance variable to approach a target value. A first and a second sensitivity of the engine performance variable are determined in response to changes in the engine control parameters. The first engine map look-up table is adjusted when the first sensitivity is greater than a threshold, and the second engine map look-up table is adjusted when the second sensitivity is greater than a threshold.

  2. Measurement of specific parameters for dose calculation after inhalation of aerols containing transuranium elements; Mesure de parametres specifiques pour le calcul de dose apres inhalation d'aerosols renfermant des elements transuraniens

    Energy Technology Data Exchange (ETDEWEB)

    Ramounet-le Gall, B.; Fritsch, P.; Abram, M.C.; Rateau, G.; Grillon, G.; Guillet, K. [Lab. de Radiotoxicologie, CEA/DSV/DRR/SRCA, Bruyeres le Chatel (France); Baude, S. [Lab. de Mesures Specifiques Gaz, CEA/DAM/DASE/SRCE, Bruyeres le Chatel (France); Berard, P. [Cabinet du Conseiller medical du CEA, CEA/DEN/DPS/LABM Saclay, Gif sur Yvette (France); Ansoborlo, E. [CEA/DEN/DRCP/CETAMA, Bagnols sur Ceze (France); Delforge, J. [Lab. de Radiotoxicologie, CEA/DSV/DRR/SRCA, Bruyeres le Chatel (France)

    2002-07-01

    A review on specific parameter measurements to calculate doses per unit of incorporation according to recommendations of the International Commission of Radiological Protection has been performed for inhaled actinide oxides. Alpha activity distribution of the particles can be obtained by autoradiography analysis using aerosol sampling filters at the work places. This allows us to characterize granulometric parameters of 'pure' actinide oxides, but complementary analysis by scanning electron microscopy is needed for complex aerosols. Dissolution parameters with their standard deviation are obtained after rat inhalation exposure, taking into account both mechanical lung clearance and actinide transfer to the blood estimated from bone retention. In vitro experiments suggest that the slow dissolution rate might decrease as a function of time following exposure. Dose calculation software packages have been developed to take into account granulometry and dissolution parameters as well as specific physiological parameters of exposed individuals. In the case of poorly soluble actinide oxides, granulometry and physiology appear as the main parameters controlling dose value, whereas dissolution only alters dose distribution. Validation of these software packages are in progress. (author)

  3. Results from an inter-laboratory comparison of pneumococcal serotype-specific IgG measurement and critical parameters that affect assay performance.

    Science.gov (United States)

    Balloch, A; Licciardi, P V; Leach, A; Nurkka, A; Tang, M L K

    2010-02-01

    Quantitation of specific IgG to polysaccharides (serotypes) of Streptococcus pneumoniae provides the basis for evaluating vaccine efficacy. Different enzyme-linked immunosorbent assay (ELISA) methods are used internationally, making comparisons between laboratories difficult. We undertook an inter-laboratory comparison between two international laboratories performing serotype-specific IgG ELISAs using a panel of well-characterized serum samples: the Murdoch Childrens Research Institute Pneumococcal Laboratory (Melbourne, Australia) and the Vaccine Immunology Laboratory, National Public Health Institute (Helsinki, Finland). While good agreement was found for the inter-laboratory comparison for most serotypes, differences in ELISA methodology influenced specific IgG measurement. Therefore, use of the World Health Organization (WHO)-based ELISA methods for measurement of serotype-specific IgG is reliable, accurate and provides consistent results between international laboratories.

  4. Realization of Wireless Monitoring Network Based on LEACH Protocol for Human Physiological Parameters%基于LEACH协议的人体生理参数无线监测网络的实现

    Institute of Scientific and Technical Information of China (English)

    李成贵; 赵利国

    2013-01-01

    Wireless human physiological parameters monitoring could real-time monitor the important physiological indices under the human motion state,could also analyze and prevent the motion dangerous.Therefore,it has the important meaning in the sports medicine.This paper presents the realization of wireless monitoring network based on LEACH protocol for human physiological parameters.The basic idea of LEACH routing algorithms was introduced firstly.The hardware circuits of ECG data acquisition node and blood oxygen acquisition node were designed and debugged.The paper focuses on the wireless monitoring network system based on NRF24L01.When finished the online debugging of function modules and system,the heart rate and blood oxygen saturation values are tested and analyzed.%无线人体生理参数监测技术可以实时监测运动状态下的人体机能信息,并可完成对运动危险实时分析及实时预防等功能,在运动医学中具有重要意义,为此设计了基于LEACH协议的无线人体生理参数监测网络系统.首先介绍了LEACH路由算法的基本思想,设计了心电采集节点和血氧采集节点的硬件电路,叙述了基于NRF24L01的无线监测网络的实现,并对各模块和整个系统进行了联机调试,最后还进行了无线心率检测和血氧饱和度组网测试.

  5. Neutron Monitors and muon detectors for solar modulation studies: Interstellar flux, yield function, and assessment of critical parameters in count rate calculations

    CERN Document Server

    Maurin, D; Derome, L; Ghelfi, A; Hubert, G

    2014-01-01

    Particles count rates at given Earth location and altitude result from the convolution of (i) the interstellar (IS) cosmic-ray fluxes outside the solar cavity, (ii) the time-dependent modulation of IS into Top-of-Atmosphere (TOA) fluxes, (iii) the rigidity cut-off (or geomagnetic transmission function) and grammage at the counter location, (iv) the atmosphere response to incoming TOA cosmic rays (shower development), and (v) the counter response to the various particles/energies in the shower. Count rates from neutron monitors or muon counters are therefore a proxy to solar activity. In this paper, we review all ingredients, discuss how their uncertainties impact count rate calculations, and how they translate into variation/uncertainties on the level of solar modulation $\\phi$ (in the simple Force-Field approximation). The main uncertainty for neutron monitors is related to the yield function. However, many other effects have a significant impact, at the 5-10% level on $\\phi$ values. We find no clear ranking...

  6. Radiation safety assessment and development of environmental radiation monitoring technology; standardization of input parameters for the calculation of annual dose from routine releases from commercial reactor effluents

    Energy Technology Data Exchange (ETDEWEB)

    Rhee, I. H.; Cho, D.; Youn, S. H.; Kim, H. S.; Lee, S. J.; Ahn, H. K. [Soonchunhyang University, Ahsan (Korea)

    2002-04-01

    This research is to develop a standard methodology for determining the input parameters that impose a substantial impact on radiation doses of residential individuals in the vicinity of four nuclear power plants in Korea. We have selected critical nuclei, pathways and organs related to the human exposure via simulated estimation with K-DOSE 60 based on the updated ICRP-60 and sensitivity analyses. From the results, we found that 1) the critical nuclides were found to be {sup 3}H, {sup 133}Xe, {sup 60}Co for Kori plants and {sup 14}C, {sup 41}Ar for Wolsong plants. The most critical pathway was 'vegetable intake' for adults and 'milk intake' for infants. However, there was no preference in the effective organs, and 2) sensitivity analyses showed that the chemical composition in a nuclide much more influenced upon the radiation dose than any other input parameters such as food intake, radiation discharge, and transfer/concentration coefficients by more than 102 factor. The effect of transfer/concentration coefficients on the radiation dose was negligible. All input parameters showed highly estimated correlation with the radiation dose, approximated to 1.0, except for food intake in Wolsong power plant (partial correlation coefficient (PCC)=0.877). Consequently, we suggest that a prediction model or scenarios for food intake reflecting the current living trend and a formal publications including details of chemical components in the critical nuclei from each plant are needed. Also, standardized domestic values of the parameters used in the calculation must replace the values of the existed or default-set imported factors via properly designed experiments and/or modelling such as transport of liquid discharge in waters nearby the plants, exposure tests on corps and plants so on. 4 figs., 576 tabs. (Author)

  7. Multi-parameter indoor environment real-time monitor based on CPLD%基于CPLD的多参数室内环境实时监测仪

    Institute of Scientific and Technical Information of China (English)

    宋佳莹; 叶树亮; 张晟; 侯德鑫

    2011-01-01

    Indoor environment monitors on the market have problems like relatively monadical measurement parameters, poor real-time and low accuracy of measurement. To solve these problems, a small size multi-parameter indoor environment real-time monitor based on CPLD is developed. Highly integrated CPLD optimized circuit structure,and its parallel operation mode ensure multiple signal acquisition of 9 indicators at the same time,which greatly improved the instrument in real time. Experimental results show that multi-parameter indoor environment real-time monitor possess high measurement precision, good real-time, reliable performance and its metrics are able to meet the national standard.%针对目前室内环境监测仪测量参数相对单一、实时性差、测量准确度低等问题,研发了基于复杂可编程逻辑器件(CPLD)的多参数测量的小型室内环境实时监测仪.CPLD的高集成度优化了电路结构,其并行工作方式同时对9项指标进行多路信号采集,大大地提高了仪器的实时性.实验结果表明:该多参数室内环境实时监测仪测量精度高,实时性好,性能可靠,各项测量指标均能够达到国家标准要求.

  8. Monitoring of trough plasma ganciclovir levels and peripheral blood cytomegalovirus (CMV)-specific CD8+ T cells to predict CMV DNAemia clearance in preemptively treated allogeneic stem cell transplant recipients.

    Science.gov (United States)

    Giménez, Estela; Solano, Carlos; Azanza, José Ramón; Amat, Paula; Navarro, David

    2014-09-01

    It is uncertain whether monitoring plasma ganciclovir (GCV) levels is useful in predicting cytomegalovirus (CMV) DNAemia clearance in preemptively treated allogeneic stem cell transplant recipients. In this observational study, including 13 episodes of CMV DNAemia treated with intravenous (i.v.) GCV or oral valganciclovir, we showed that monitoring trough plasma GCV levels does not reliably predict response to therapy. Rather, immunological monitoring (pp65 and immediate-early [IE]-1-specific gamma interferon [IFN-γ]-producing CD8+ T cells) appeared to perform better for this purpose.

  9. The neo-epitope specific PRO-C3 ELISA measures true formation of type III collagen associated with liver and muscle parameters

    DEFF Research Database (Denmark)

    Nielsen, Mette J; Nedergaard, Anders F; Sun, Shu;

    2013-01-01

    AIM: The present study describes the assessment of true formation of type III collagen in different pathologies using a neo-epitope specific competitive Enzyme-linked immunosorbent assay (ELISA) towards the N-terminal propeptide of type III collagen (PRO-C3). METHODS: The monoclonal antibody...... was raised against the N-protease mediated cleavage site of the N-terminal propeptide of type III collagen and a competitive ELISA was developed using the selected antibody. The assay was evaluated in relation to neo-epitope specificity, technical performance, and as a marker for liver fibrosis and muscle...... mass using the rat carbon tetrachloride (CCl4) model and a study of immobilization induced muscle loss in humans, respectively. RESULTS: The ELISA was neo-epitope specific, technically stable and can be assessed in serum and plasma samples. In the CCl4 liver fibrosis model it was observed that serum...

  10. Specific microbial gene abundances and soil parameters contribute to C, N, and greenhouse gas process rates after land use change in Southern Amazonian Soils

    Directory of Open Access Journals (Sweden)

    Daniel Renato Lammel

    2015-10-01

    Full Text Available Ecological processes regulating soil carbon (C and nitrogen (N cycles are still poorly understood, especially in the world’s largest agricultural frontier in Southern Amazonia. We analyzed soil parameters in samples from pristine rainforest and after land use change to pasture and crop fields, and correlated them with abundance of functional and phylogenetic marker genes (amoA, nirK, nirS, norB, nosZ, nifH, mcrA, pmoA, and 16S/18S rRNA. Additionally, we integrated these parameters using path analysis and multiple regressions. Following forest removal, concentrations of soil C and N declined, and pH and nutrient levels increased, which influenced microbial abundances and biogeochemical processes. A seasonal trend was observed, suggesting that abundances of microbial groups were restored to near native levels after the dry winter fallow. Integration of the marker gene abundances with soil parameters using path analysis and multiple regressions provided good predictions of biogeochemical processes, such as the fluxes of NO3, N2O, CO2, and CH4. In the wet season, agricultural soil showed the highest abundance of nitrifiers (amoA and Archaea, however forest soils showed the highest abundances of denitrifiers (nirK, nosZ and high N, which correlated with increased N2O emissions. Methanogens (mcrA and methanotrophs (pmoA were more abundant in forest soil, but methane flux was highest in pasture sites, which was related to soil compaction. Rather than analyzing direct correlations, the data integration using multivariate tools provided a better overview of biogeochemical processes. Overall, in the wet season, land use change from forest to agriculture reduced the abundance of different functional microbial groups related to the soil C and N cycles; integrating the gene abundance data and soil parameters provided a comprehensive overview of these interactions. Path analysis and multiple regressions addressed the need for more comprehensive approaches

  11. Change of parameters of an estimation of gender differences of results of swimmer's performance under specifications of Uniform sports classification of Ukraine for 2009-2012

    Directory of Open Access Journals (Sweden)

    Ganchar A.I.

    2010-05-01

    Full Text Available Due levels and degrees of forming skills of the sporting swimming are considered for men and women on different distances. Likenesses and distinctions are rotined in the successive estimation of the state of preparedness level of swimmers of different floor. Likenesses and differences are exposed in the norms of swimming preparedness for the representatives of sex of men and womanish on Single sporting classification. The parameters of evaluation of dynamics of norms of swimming preparedness are presented. They allow objectively to estimate the level of bit requirements taking into account gender approach for the representatives of different age-dependent groups and sporting qualification.

  12. A novel high-throughput multi-parameter flow cytometry based method for monitoring and rapid characterization of microbiome dynamics in anaerobic systems.

    Science.gov (United States)

    Dhoble, Abhishek S; Bekal, Sadia; Dolatowski, William; Yanz, Connor; Lambert, Kris N; Bhalerao, Kaustubh D

    2016-11-01

    A novel multidimensional flow cytometry based method has been demonstrated to monitor and rapidly characterize the dynamics of the complex anaerobic microbiome associated with perturbations in external environmental factors. While community fingerprinting provides an estimate of the meta genomic structure, flow cytometry provides a fingerprint of the community morphology including its autofluorescence spectrum in a high-throughput manner. Using anaerobic microbial consortia perturbed with the controlled addition of various carbon sources, it is possible to quantitatively discriminate between divergent microbiome analogous to community fingerprinting techniques using automated ribosomal intergenic spacer analysis (ARISA). The utility of flow cytometry based method has also been demonstrated in a fully functional industry scale anaerobic digester to distinguish between microbiome composition caused by varying hydraulic retention time (HRT). This approach exploits the rich multidimensional information from flow cytometry for rapid characterization of the dynamics of microbial communities.

  13. Comparing equivalent thermal, high pressure and pulsed electric field processes for mild pasteurization of orange juice: Part II: Impact on specific chemical and biochemical quality parameters

    NARCIS (Netherlands)

    Vervoort, L.; Plancken, van der I.; Grauwet, T.; Timmermans, R.A.H.; Mastwijk, H.C.; Matser, A.M.; Hendrickx, M.E.; Loey, van A.

    2011-01-01

    The impact of thermal, high pressure (HP) and pulsed electric field (PEF) processing for mild pasteurization of orange juice was compared on a fair basis, using processing conditions leading to an equivalent degree of microbial inactivation. Examining the effect on specific chemical and biochemical

  14. Research of Multiple Physiological Parameters Monitoring System for Sub-healthy Groups%亚健康人群多生理参数监护系统的研究

    Institute of Scientific and Technical Information of China (English)

    余成波; 何强; 李芮; 谭俊; 余磊

    2013-01-01

    The body's blood pressure, ECG, body temperature and other physiological parameters are the most basic and important life indicators. It will help to keep abreast of the patient's physical condition and provide an accurate basis to the clinicians to have real-time monitoring of physiological parameters. At present, these products at the domestic market have the disadvantages of can't being collected multiple physiological parameters simultaneously, bulky and being inconvenient to carry, not real-time data collection. To this end, a design method of multiple physiological parameters monitoring system based on ZigBee has been proposed in this paper. First,the physiological parameters measurement module is used to collect the physiological signals of human body,and then the ZigBee module is used to transfer the collected physiological signals by a wireless way to the monitoring terminal as a reference for clinicians. The experiment verifies that the system is reliable,low cost,fast data transfer rate,so,it is of great significance for sub-health people.%人体的血压、心电、体温等生理参数是人体最基本、最重要的生命指标.对老龄人口、亚健康人员及危重病人生理参数进行实时监测,有利于及时了解人员的身体状况,为临床医生的诊断和治疗提供准确的依据.针对目前国内的这类监护产品存在不能同时采集多种生理参数,体积较大,不方便携带等弊端,该文提出了一种基于IEEE802.15.4标准的低功耗个域网协议(ZigBee)的多生理参数监护系统的设计方法.首先利用生理参数检测模块采集人体各生理信号,然后通过ZigBee模块将采集的生理信号经无线发送方式发送至监控终端供临床医生参考.实验证明该系统稳定可靠,成本低,数据传输速率较快,对老龄人口、亚健康人员及危重病人的监护及远程诊断有极大意义.

  15. Estimate of the lower-limb-specific muscle parameters during bipedal walking for humans, apes and early hominids with the implications for the evolution of body proportion

    Institute of Scientific and Technical Information of China (English)

    Wang Weijie

    2007-01-01

    Modern human has different body proportion from early hominids and great apes. Comparing with others, in general, modern human adults have relatively long lower limb and heavier body weight. Since the lower limbs provide support to the whole body and play an important role in walking, it is proposed that the ratio of the lower limb to the whole body for modern human could be beneficial to bipedal walking. This study tried to estimate the muscle parameters of the lower limb in walking for the subjects with various body proportions. Using a simplified musculoskeletal model, some muscle parameters of the lower limb, e.g. muscle force, stress, work and power, were estimated for modern human adult, child, AL 288-1 (the fossil specimens of Australopithecus afarensis, 3.18 million years old) and apes. The results show that with the body proportion modern human adult spends less muscle work and power in walking than other subjects. The results imply that using the cost of transport (i.e. the muscle work of the lower limb per unit of displacement) as the criteria, the early hominids, if their body proportions were structurally similar to AL 288-1, could evolve towards what modern human adult looks like, in order to save energy during bipedal walking.

  16. Fiber-optic sensors for monitoring patient physiological parameters: a review of applicable technologies and relevance to use during magnetic resonance imaging procedures.

    Science.gov (United States)

    Dziuda, Łukasz

    2015-01-01

    The issues involved with recording vital functions in the magnetic resonance imaging (MRI) environment using fiber-optic sensors are considered in this paper. Basic physiological parameters, such as respiration and heart rate, are fundamental for predicting the risk of anxiety, panic, and claustrophobic episodes in patients undergoing MRI examinations. Electronic transducers are generally hazardous to the patient and are prone to erroneous operation in heavily electromagnetically penetrated MRI environments; however, nonmetallic fiber-optic sensors are inherently immune to electromagnetic effects and will be crucial for acquiring the above-mentioned physiological parameters. Forty-seven MRI-tested or potentially MRI-compatible sensors have appeared in the literature over the last 20 years. The author classifies these sensors into several categories and subcategories, depending on the sensing element placement, method of application, and measure and type. The author includes five in-house-designed fiber Bragg grating based sensors and shares experience in acquiring physiological measurements during MRI scans. This paper aims to systematize the knowledge of fiber-optic techniques for recording life functions and to indicate the current directions of development in this area.

  17. Fiber-optic sensors for monitoring patient physiological parameters: a review of applicable technologies and relevance to use during magnetic resonance imaging procedures

    Science.gov (United States)

    Dziuda, Łukasz

    2015-01-01

    The issues involved with recording vital functions in the magnetic resonance imaging (MRI) environment using fiber-optic sensors are considered in this paper. Basic physiological parameters, such as respiration and heart rate, are fundamental for predicting the risk of anxiety, panic, and claustrophobic episodes in patients undergoing MRI examinations. Electronic transducers are generally hazardous to the patient and are prone to erroneous operation in heavily electromagnetically penetrated MRI environments; however, nonmetallic fiber-optic sensors are inherently immune to electromagnetic effects and will be crucial for acquiring the above-mentioned physiological parameters. Forty-seven MRI-tested or potentially MRI-compatible sensors have appeared in the literature over the last 20 years. The author classifies these sensors into several categories and subcategories, depending on the sensing element placement, method of application, and measurand type. The author includes five in-house-designed fiber Bragg grating based sensors and shares experience in acquiring physiological measurements during MRI scans. This paper aims to systematize the knowledge of fiber-optic techniques for recording life functions and to indicate the current directions of development in this area.

  18. An integrated multi-parameter monitoring approach for the quantification and mitigation of the climate change impact on the coasts of Eastern Crete, S. Aegean Sea (Project AKTAIA)

    Science.gov (United States)

    Ghionis, George; Alexandrakis, George; Karditsa, Aikaterini; Sifnioti, Dafni; Vousdoukas, Michalis; Andreadis, Olympos; Petrakis, Stelios; Poulos, Serafim; Velegrakis, Adonis; Kampanis, Nikolaos; Lipakis, Michalis

    2014-05-01

    The AKTAIA project aims at the production of new knowledge regarding the forms of manifestation of the climate change and its influence on the stability and evolution of the coastal landforms along the shoreline of eastern Crete (approximate length: 757 km), taking into account the various aspects of human intervention. Aerial photographs, satellite images and orthophotomaps have been used to produce a detailed coastline map and to study the morphological characteristics of the coastal zone of Eastern Crete. More than 100 beach zones have been visited during three field campaigns, which included geomorphological and human intervention mapping, topographic, meteorological and oceanographic measurements and sedimentological sampling and observations. In addition, two pilot sites (one in the north and one in the south part of Crete) are being monitored, via the installation of coastal video monitoring systems, shore-based meteorological stations and wave-tide recorders installed in the nearshore zone. Detailed seafloor mapping with the use of side scan sonar and scuba diving and bathymetric surveys were conducted in the two pilot sites. Meteorological and oceanographic data from all existing land-based meteorological stations, oceanographic buoys and the ERA-interim dataset are used to determine the wind and wave climate of each beach. The collected climatic, sedimentological and coastal environmental data are being integrated in a GIS database that will be used to forecast the climatic trends in the area of Crete for the next decades and to model the impact of the climatic change on the future evolution of the coastal zone. New methodologies for the continuous monitoring of land-sea interaction and for the quantification of the loss of sensitive coastal zones due to sea-level rise and a modified Coastal Vulnerability Index for a comparative evaluation of the vulnerability of the coasts are being developed. Numerical modelling of the nearshore hydrodynamics and the

  19. Adaptation of short-term plasticity parameters via error-driven learning may explain the correlation between activity-dependent synaptic properties, connectivity motifs and target specificity.

    Science.gov (United States)

    Esposito, Umberto; Giugliano, Michele; Vasilaki, Eleni

    2014-01-01

    The anatomical connectivity among neurons has been experimentally found to be largely non-random across brain areas. This means that certain connectivity motifs occur at a higher frequency than would be expected by chance. Of particular interest, short-term synaptic plasticity properties were found to colocalize with specific motifs: an over-expression of bidirectional motifs has been found in neuronal pairs where short-term facilitation dominates synaptic transmission among the neurons, whereas an over-expression of unidirectional motifs has been observed in neuronal pairs where short-term depression dominates. In previous work we found that, given a network with fixed short-term properties, the interaction between short- and long-term plasticity of synaptic transmission is sufficient for the emergence of specific motifs. Here, we introduce an error-driven learning mechanism for short-term plasticity that may explain how such observed correspondences develop from randomly initialized dynamic synapses. By allowing synapses to change their properties, neurons are able to adapt their own activity depending on an error signal. This results in more rich dynamics and also, provided that the learning mechanism is target-specific, leads to specialized groups of synapses projecting onto functionally different targets, qualitatively replicating the experimental results of Wang and collaborators.

  20. Inter-laboratory evaluation of the performance parameters of a Lateral Flow Test device for the detection of Bluetongue virus-specific antibodies.

    Science.gov (United States)

    Hanon, Jean-Baptiste; Vandenberge, Valerie; Deruelle, Matthias; De Leeuw, Ilse; De Clercq, Kris; Van Borm, Steven; Koenen, Frank; Liu, Lihong; Hoffmann, Bernd; Batten, Carrie Anne; Zientara, Stéphan; Breard, Emmanuel; Van der Stede, Yves

    2016-02-01

    Bluetongue (BT) is a viral vector-borne disease affecting domestic and wild ruminants worldwide. In this study, a commercial rapid immuno-chromatographic method or Lateral Flow Test (LFT) device, for the detection of BT virus-specific antibodies in animal serum, was evaluated in an international inter-laboratory proficiency test. The evaluation was done with sera samples of variable background (ruminant species, serotype, field samples, experimental infections, vaccinated animals). The diagnostic sensitivity was 100% (95% C.I. [90.5-100]) and the diagnostic specificity was 95.2% (95% C.I. [76.2-99.9]). The repeatability (accordance) and reproducibility (concordance) were 100% for seropositive samples but were lower for two of the seronegative samples (45% and 89% respectively). The analytical sensitivity, evaluated by testing positive sera at increasing dilutions was better for the BT LFT compared to some commercial ELISAs. Seroconversion of an infected sheep was detected at 4 days post infection. Analytical specificity was impaired by cross-reactions observed with some of the samples seropositive for Epizootic Haemorrhagic Disease Virus (EHDV). The agreement (Cohen's kappa) between the LFT and a commercial BT competitive ELISA was 0.79 (95% CI [0.62-0.95]). Based on these results, it can be concluded that the BT LFT device is a rapid and sensitive first-line serological test that can be used in the field, especially in areas endemic for the disease where there is a lack of diagnostic facilities.

  1. State and parameter estimation in bio processes

    Energy Technology Data Exchange (ETDEWEB)

    Maher, M.; Roux, G.; Dahhou, B. [Centre National de la Recherche Scientifique (CNRS), 31 - Toulouse (France)]|[Institut National des Sciences Appliquees (INSA), 31 - Toulouse (France)

    1994-12-31

    A major difficulty in monitoring and control of bio-processes is the lack of reliable and simple sensors for following the evolution of the main state variables and parameters such as biomass, substrate, product, growth rate, etc... In this article, an adaptive estimation algorithm is proposed to recover the state and parameters in bio-processes. This estimator utilizes the physical process model and the reference model approach. Experimentations concerning estimation of biomass and product concentrations and specific growth rate, during batch, fed-batch and continuous fermentation processes are presented. The results show the performance of this adaptive estimation approach. (authors) 12 refs.

  2. Monitoring the Dissolution of a Limestone in CO2-rich Brine Using 4D Synchrotron Microtomography: Impact on Single and Multiphase Flow Parameters

    Science.gov (United States)

    Voltolini, M.; Ajo Franklin, J. B.

    2013-12-01

    Carbonates are common reservoir rocks for both CO2 EOR operations (e.g. Permian Basin, Weyburn) as well as conventional saline aquifer GCS studies (e.g. MRSP, Big Sky Kevin Dome Project). While the dissolution of carbonates in high pCO2 brines is relatively well-studied, only recently have we developed the imaging tools required to dynamically monitor dissolution-induced transformations in pore architecture an macroscopic samples. The details of such transformations are crucial in understanding the coupling between between reactive chemistry and reservoir flow, particularly in GCS where large scale variations in pH are induced during CO2 injection. A complicating factor is the range of dissolution architectures generated under varying flow rate and reaction conditions; these variations, typically understood in terms of advective Dahmkohler (Da) number, generate structures between localized wormholes and uniform dissolution. However, to date, minimal work has been done evaluating the relationship between Da, porosity, and capillary entry pressure during carbonate dissolution; this relationship is crucial when attempting to predict CO2 drainage processes in heterogeneous carbonate systems and could provide a mechanism for long term expansion of the plume footprint through lower permeability lamina. We present results from a 4D synchrotron XR microtomography experiment which monitored dissolution in a model carbonate, a small core from the well-studied Bedford limestone. Ten datasets, spanning a wide range of states in micro-architecture, were acquired over a multi-day acquisition campaign at beamline 8.3.2 (Advanced Light Source). Dissolution was induced by injection of water saturated with CO2; while the run was conducted at low pressure (~30 psi), significant dissolution occurred over the duration of the experiment. Imagery of the resulting pore-scale modifications was reconstructed, filtered, and segmented to yield a timelapse movie of the dissolution process

  3. Repeatability of quantitative parameters of 18F-fluoride PET/CT and biochemical tumour and specific bone remodelling markers in prostate cancer bone metastases.

    Science.gov (United States)

    Wassberg, Cecilia; Lubberink, Mark; Sörensen, Jens; Johansson, Silvia

    2017-12-01

    18F-fluoride PET/CT exhibits high sensitivity to delineate and measure the extent of bone metastatic disease in patients with prostate cancer. 18F-fluoride PET/CT could potentially replace traditional bone scintigraphy in clinical routine and trials. However, more studies are needed to assess repeatability and biological uptake variation. The aim of this study was to perform test-retest analysis of quantitative PET-derived parameters and blood/serum bone turnover markers at the same time point. Ten patients with prostate cancer and verified bone metastases were prospectively included. All underwent two serial 18F-fluoride PET/CT at 1 h post-injection. Up to five dominant index lesions and whole-body 18F-fluoride skeletal tumour burden were recorded per patient. Lesion-based PET parameters were SUVmax, SUVmean and functional tumour volume applying a VOI with 50% threshold (FTV50%). The total skeletal tumour burden, total lesion 18F-fluoride (TLF), was calculated using a threshold of SUV of ≥15. Blood/serum biochemical bone turnover markers obtained at the time of each PET were PSA, ALP, S-osteocalcin, S-beta-CTx, 1CTP and BAP. A total of 47 index lesions and a range of 2-122 bone metastases per patient were evaluated. Median time between 18F-fluoride PET/CT was 7 days (range 6-8 days). Repeatability coefficients were for SUVmax 26%, SUVmean 24%, FTV50% for index lesions 23% and total skeletal tumour burden (TLF) 35%. Biochemical bone marker repeatability coefficients were for PSA 19%, ALP 23%, S-osteocalcin 18%, S-beta-CTx 22%, 1CTP 18% and BAP 23%. Quantitative 18F-fluoride uptake and simultaneous biochemical bone markers measurements are reproducible for prostate cancer metastases and show similar magnitude in test-retest variation.

  4. Effects of environmental parameters and irrigation on the turgor pressure of banana plants measured using the non-invasive, online monitoring leaf patch clamp pressure probe.

    Science.gov (United States)

    Zimmermann, U; Rüger, S; Shapira, O; Westhoff, M; Wegner, L H; Reuss, R; Gessner, P; Zimmermann, G; Israeli, Y; Zhou, A; Schwartz, A; Bamberg, E; Zimmermann, D

    2010-05-01

    Turgor pressure provides a sensitive indicator for irrigation scheduling. Leaf turgor pressure of Musa acuminate was measured by using the so-called leaf patch clamp pressure probe, i.e. by application of an external, magnetically generated and constantly retained clamp pressure to a leaf patch and determination of the attenuated output pressure P(p) that is highly correlated with the turgor pressure. Real-time recording of P(p) values was made using wireless telemetric transmitters, which send the data to a receiver base station where data are logged and transferred to a GPRS modem linked to an Internet server. Probes functioned over several months under field and laboratory conditions without damage to the leaf patch. Measurements showed that the magnetic-based probe could monitor very sensitively changes in turgor pressure induced by changes in microclimate (temperature, relative humidity, irradiation and wind) and irrigation. Irrigation effects could clearly be distinguished from environmental effects. Interestingly, oscillations in stomatal aperture, which occurred frequently below turgor pressures of 100 kPa towards noon at high transpiration or at high wind speed, were reflected in the P(p) values. The period of pressure oscillations was comparable with the period of oscillations in transpiration and photosynthesis. Multiple probe readings on individual leaves and/or on several leaves over the entire height of the plants further emphasised the great impact of this non-invasive turgor pressure sensor system for elucidating the dynamics of short- and long-distance water transport in higher plants.

  5. Double-blind Y chromosome microdeletion analysis in men with known sperm parameters and reproductive hormone profiles: microdeletions are specific for spermatogenic failure.

    Science.gov (United States)

    Krausz, C; Rajpert-De Meyts, E; Frydelund-Larsen, L; Quintana-Murci, L; McElreavey, K; Skakkebaek, N E

    2001-06-01

    Y chromosome microdeletions have been reported as a possible genetic factor of male infertility. Despite a large number of studies in this subject, there is still considerable debate and confusion surrounding the role of Y chromosome microdeletions in male infertility. This has been further compounded by observations of Y microdeletions in fertile males. The aim of the present study was to evaluate: 1) the incidence of Y microdeletions in control male population and infertile males, where complete semen and hormonal analysis was available to define whether Y microdeletions are specific for spermatogenic failure or if they can be found also in normospermic men; and 2) whether the suboptimal semen quality reported in Denmark is associated with a higher incidence of Y microdeletions in respect to other populations. Double-blind molecular study of deletions was performed in 138 consecutive patients seeking intracytoplasmic sperm injection treatment, 100 men of known fertility, and 107 young military conscripts from the general Danish population. Microdeletions or gene-specific deletions were not detected in normospermic subjects or in subfertile men with a sperm count of more than 1 x 10(6)/mL. Deletions of the Azoospermia factor (AZF)c region were detected in 17% of individuals with idiopathic azoo/cryptozoospermia and in 7% of individuals with nonidiopathic azoo/cryptozoospermia. The data indicate that: 1) the composition of the study population is the major factor in determining deletion frequency; 2) Y chromosome microdeletions are specifically associated with severe spermatogenic failure; therefore, the protocol described here is reliable for the routine clinical workup of severe male factor infertility; and 3) the frequency of Yq microdeletions in the Danish population is similar to that from other countries and argues against the involvement of microdeletions in the relatively low sperm count of the Danish population.

  6. Site-specific growth of Au-Pd alloy horns on Au nanorods: A platform for highly sensitive monitoring of catalytic reactions by surface enhancement raman spectroscopy

    KAUST Repository

    Huang, Jianfeng

    2013-06-12

    Surface-enhanced Raman scattering (SERS) is a highly sensitive probe for molecular detection. The aim of this study was to develop an efficient platform for investigating the kinetics of catalytic reactions with SERS. To achieve this, we synthesized a novel Au-Pd bimetallic nanostructure (HIF-AuNR@AuPd) through site-specific epitaxial growth of Au-Pd alloy horns as catalytic sites at the ends of Au nanorods. Using high-resolution electron microscopy and tomography, we successfully reconstructed the complex three-dimensional morphology of HIF-AuNR@AuPd and identified that the horns are bound with high-index {11l} (0.25 < l < 0.43) facets. With an electron beam probe, we visualized the distribution of surface plasmon over the HIF-AuNR@AuPd nanorods, finding that strong longitudinal surface plasmon resonance concentrated at the rod ends. This unique crystal morphology led to the coupling of high catalytic activity with a strong SERS effect at the rod ends, making HIF-AuNR@AuPd an excellent bifunctional platform for in situ monitoring of surface catalytic reactions. Using the hydrogenation of 4-nitrothiophenol as a model reaction, we demonstrated that its first-order reaction kinetics could be accurately determined from this platform. Moreover, we clearly identified the superior catalytic activity of the rod ends relative to that of the rod bodies, owing to the different SERS activities at the two positions. In comparison with other reported Au-Pd bimetallic nanostructures, HIF-AuNR@AuPd offered both higher catalytic activity and greater detection sensitivity. © 2013 American Chemical Society.

  7. Estimating patient specific uncertainty parameters for adaptive treatment re-planning in proton therapy using in vivo range measurements and Bayesian inference: application to setup and stopping power errors

    Science.gov (United States)

    Labarbe, Rudi; Janssens, Guillaume; Sterpin, Edmond

    2016-09-01

    In proton therapy, quantification of the proton range uncertainty is important to achieve dose distribution compliance. The promising accuracy of prompt gamma imaging (PGI) suggests the development of a mathematical framework using the range measurements to convert population based estimates of uncertainties into patient specific estimates with the purpose of plan adaptation. We present here such framework using Bayesian inference. The sources of uncertainty were modeled by three parameters: setup bias m, random setup precision r and water equivalent path length bias u. The evolution of the expectation values E(m), E(r) and E(u) during the treatment was simulated. The expectation values converged towards the true simulation parameters after 5 and 10 fractions, for E(m) and E(u), respectively. E(r) settle on a constant value slightly lower than the true value after 10 fractions. In conclusion, the simulation showed that there is enough information in the frequency distribution of the range errors measured by PGI to estimate the expectation values and the confidence interval of the model parameters by Bayesian inference. The updated model parameters were used to compute patient specific lateral and local distal margins for adaptive re-planning.

  8. Combining PLS regression with portable NIR spectroscopy to on-line monitor quality parameters in intact olives for determining optimal harvesting time.

    Science.gov (United States)

    Fernández-Espinosa, Antonio J

    2016-01-01

    This study presents a systematized method for predicting water content, fat content and free acidity in olive fruits by on-line NIR Spectroscopy combined with chemometric techniques (PCA, LDA and PLSR). Three cultivar varieties of Olea europaea - Hojiblanca cv., Picual cv. and Arbequina cv. - were monitored. Five olive cultivation areas of Southern Spain (Andalucia) and Southern Portugal (Alentejo) were studied in 2011 and 2012. 465 olive samples were collected during the ripening process (non-mature olives) and compared with other 203 samples of mature olives collected at the final ripening stage. NIR spectra were measured directly in the olive fruits in the wavelength region from 1000 to 2300 nm in reflectance mode. The reference analyses were performed on the olive paste by oven drying for the moisture, by mini-Soxhlet extraction for the fat content and by acid titration of the oil extracted from the olive paste. Calibrations and predictive models were developed by Partial Least Square Regression (PLSR) previous Principal Component and Linear Discriminant analyses (PCA and LDA) were employed as exploratory and clean-up tools of data sets. The final models obtained for the total samples showed acceptable statistics of prediction with R(2)=0.88, RMSEV%=4.88 and RMSEP%=4.98 for water content, R(2)=0.76, RMSECV%=19.5 and RMSEP%=20.0 for fat content and R(2)=0.83, RMSECV%=36.8 and RMSEP%=38.8 for free acidity. Regression coefficients were better for only one maturity state (ripe period) than for olive fruit with different composition (ripening period). All models obtained were applied to predict LQPs on a new set of samples with satisfactory results, a good prediction potential of the models.

  9. Monitoring the effects of exposure to lead and cadmium in working and living environment through standard biochemical blood parameters and liver endonucleases activity

    Directory of Open Access Journals (Sweden)

    Nikolić Ružica S.

    2011-01-01

    Full Text Available Heavy metals as pollutants in the working and living environment are a serious health and environmental problem because they are toxic, non-biodegradable, accumulate in living systems and have a long half-life in soil. Sources of lead contamination are combustion products in the chemical industry and metallurgy, industrial waste water, landfills, traffic etc. Lead enters into the body via the food chain and drinking water. In the body lead is deposited in the liver, kidneys, brain and mineral tissues. Excretion of lead causes damage to the epithelial cells of certain organs. High level exposure to cadmium is usually the result of environmental pollution by human activities. Exposure to cadmium can lead to acute and chronic tissue damage of various organs, including liver and kidneys in humans and in animals. In this paper we analyzed the effects of lead and cadmium exposure, in working and living environment, on the model system of experimental animals, particularly the activity of certain liver enzymes, acid and alkaline DNase, and standard biochemical blood parameters. The study showed that lead and cadmium significantly affect the protein content, red blood cells, hemoglobin and hematocrit, and the activity of liver enzymes. This harmful effect of this toxic metal can be reduced by the supplements.

  10. Long-term monitoring of the Dead Sea level and brine physico-chemical parameters “from 1987 to 2008”

    Science.gov (United States)

    Khlaifat, Abdelaziz; Hogan, Michael; Phillips, Gary; Nawayseh, Khalid; Amira, Jamal; Talafeha, Emad

    2010-05-01

    The Dead Sea brine quality was assessed in order to provide scientific basis for researchers' needs. Four times a month, brine samples were collected from the Arab Potash Company (APC) point of intake and analyzed for physico-chemical parameters in the laboratory over 22 years, and Dead Sea surface temperature and level were measured during each sampling. The mean density values for the collected samples during the last 22 years ranged from 1.2040 g/cm 3 in 1992 to 1.2393 g/cm 3 in 2007, with an average value of 1.2376 g/cm 3. The brine salinity values ranged from 293.6 in 1992 to 339.3 g/l in 2008 with an average value of 337.73 g/l. The ionic dominance observed was Cl - > Mg ++ > Na + > Ca ++ > K +. The results showed that diluting the Dead Sea brine affects both magnesium and sodium chlorides significantly because of their high solubilities in fresh water and their large reserves.

  11. Monitoring of β-d-Galactosidase Activity as a Surrogate Parameter for Rapid Detection of Sewage Contamination in Urban Recreational Water

    Directory of Open Access Journals (Sweden)

    Ingun Tryland

    2016-02-01

    Full Text Available Simple, automated methods are required for rapid detection of wastewater contamination in urban recreational water. The activity of the enzyme β-d-galactosidase (GAL can rapidly (<2 h be measured by field instruments, or a fully automated instrument, and was evaluated as a potential surrogate parameter for estimating the level of fecal contamination in urban waters. The GAL-activity in rivers, affected by combined sewer overflows, increased significantly during heavy rainfall, and the increase in GAL-activity correlated well with the increase in fecal indicator bacteria. The GAL activity in human feces (n = 14 was high (mean activity 7 × 107 ppb MU/hour and stable (1 LOG10 variation, while the numbers of Escherichia coli and intestinal enterococci varied by >5 LOG10. Furthermore, the GAL-activity per gram feces from birds, sheep and cattle was 2–3 LOG10 lower than the activity from human feces, indicating that high GAL-activity in water may reflect human fecal pollution more than the total fecal pollution. The rapid method can only be used to quantify high levels of human fecal pollution, corresponding to about 0.1 mg human feces/liter (or 103 E. coli/100 mL, since below this limit GAL-activity from non-fecal environmental sources may interfere.

  12. Maternal thyroid parameters in pregnant women with different ethnic backgrounds: Do ethnicity-specific reference ranges improve the diagnosis of subclinical hypothyroidism?

    Science.gov (United States)

    Veltri, Flora; Belhomme, Julie; Kleynen, Pierre; Grabczan, Lidia; Rozenberg, Serge; Pepersack, Thierry; Poppe, Kris

    2017-06-01

    Guidelines on the management of thyroid dysfunction during pregnancy have recently been updated and, for the diagnosis of subclinical hypothyroidism (SCH), a thyroid-stimulating hormone (TSH) upper reference limit (cut-off) of 4.0 mIU/L has been proposed when no institutional values are available. It is also suggested that serum TSH and thyroid autoimmunity (TAI) may be different according to the ethnic background of the women. We therefore determined the prevalence of TAI and SCH in pregnant women with different ethnic backgrounds and, to define SCH, we used different first trimester TSH upper reference cut-offs (institutional, ethnicity-specific, 2.5 mIU/L [Endocrine Society] and 4.0 mIU/L [American Thyroid Association]). Cross-sectional data analysis of 1683 pregnant women nested within an ongoing prospective database of pregnant women. The study was performed in a single centre in Brussels, Belgium. During the first antenatal visit, thyroid peroxidase antibodies (TPO-abs), TSH and free T4 (FT4) were measured and baseline characteristics recorded. Data from 481 women with sub-Saharan (SaBg; 28.6%), 754 North African (NaBg; 44.8%) and 448 Caucasian (CaBg; 26.6%) backgrounds were analysed. For the calculation of TSH reference ranges, women with TAI, outliers, twin and assisted pregnancies were excluded. The prevalence of TAI was significantly lower in the SaBg group than in NaBg and CaBg groups (3.3% vs 8.6% and 11.1%; Pwomen with SCH was comparable between all groups when 2.5 mIU/L was used as cut-off, but when 4.0 mIU/L or the institutional cut-off (3.74 mIU/L) was used, it was significantly higher in the CaBg group vs the NaBg group (5.4% vs 2.1% and 7.1% vs 3.3%, P=.008 and .013, respectively). The use of ethnicity-specific cut-offs did not change the prevalence of SCH as compared to the use of institutional cut-offs. However, when these cut-offs were used, the prevalence of SCH reduced by >70% (4.5% instead of 16.7%; PPregnant women with a sub

  13. Comparison of UV irradiances from Aura/Ozone Monitoring Instrument (OMI with Brewer measurements at El Arenosillo (Spain – Part 1: Analysis of parameter influence

    Directory of Open Access Journals (Sweden)

    M. Antón

    2010-07-01

    Full Text Available The main objective of this study is to compare the erythemal UV irradiance (UVER and spectral UV irradiances (at 305, 310 and 324 nm from the Ozone Monitoring Instrument (OMI onboard NASA EOS/Aura polar sun-synchronous satellite (launched in July 2004, local equator crossing time 01:45 p.m. with ground-based measurements from the Brewer spectrophotometer #150 located at El Arenosillo (South of Spain. The analyzed period comprises more than four years, from October 2004 to December 2008. The effects of several factors (clouds, aerosols and the solar elevation on OMI-Brewer comparisons were analyzed. The proxies used for each factor were: OMI Lambertian Equivalent Reflectivity (LER at 360 nm (clouds, the aerosol optical depth (AOD at 440 nm measured from the ground-based Cimel sun-photometer (http://aeronet.gsfc.nasa.gov, and solar zenith angle (SZA at OMI overpass time. The comparison for all sky conditions reveals positive biases (OMI higher than Brewer 12.3% for UVER, 14.2% for UV irradiance at 305 nm, 10.6% for 310 nm and 8.7% for 324 nm. The OMI-Brewer root mean square error (RMSE is reduced when cloudy cases are removed from the analysis, (e.g., RMSE~20% for all sky conditions and RMSE smaller than 10% for cloud-free conditions. However, the biases remain and even become more significant for the cloud-free cases with respect to all sky conditions. The mentioned overestimation is partially due to aerosol extinction influence. In addition, the differences OMI-Brewer typically decrease with SZA except days with high aerosol loading, when the bias is near constant. The seasonal dependence of the OMI-Brewer difference for cloud-free conditions is driven by aerosol climatology.

    To account for the aerosol effect, a first evaluation in order to compare with previous TOMS results (Antón et al., 2007 was performed. This comparison shows that the OMI bias is between +14% and +19% for

  14. Incubator proof miniaturized Holomonitor to in situ monitor cancer cells exposed to green tea polyphenol and preosteoblast cells adhering on nanostructured titanate surfaces: validity of the measured parameters and their corrections.

    Science.gov (United States)

    Peter, Beatrix; Nador, Judit; Juhasz, Krisztina; Dobos, Agnes; Körösi, Laszlo; Székács, Inna; Patko, Daniel; Horvath, Robert

    2015-06-01

    The in situ observation of cell movements and morphological parameters over longer periods of time under physiological conditions is critical in basic cell research and biomedical applications. The quantitative phase-contrast microscope applied in this study has a remarkably small size, therefore it can be placed directly into a humidified incubator. Here, we report on the successful application of this M4 Holomonitor to observe cancer cell motility, motility speed, and migration in the presence of the green tea polyphenol, epigallocatechin gallate, as well as to monitor the adhesion of preosteoblast cells on nanostructured titanate coatings, relevant for biomedical applications. A special mechanical stage was developed to position the sample into that range of the optical arrangement where digital autofocusing works with high reproducibility and precision. By in-depth analyzing the obtained single cell morphological parameters, we show that the limited vertical resolution of the optical setup results in underestimated single cell contact area and volume and overestimated single cell averaged thickness. We propose a simple model to correct the recorded data to obtain more precise single cell parameters. We compare the results with the kinetic data recorded by a surface sensitive optical biosensor, optical waveguide lightmode spectroscopy.

  15. Incubator proof miniaturized Holomonitor to in situ monitor cancer cells exposed to green tea polyphenol and preosteoblast cells adhering on nanostructured titanate surfaces: validity of the measured parameters and their corrections

    Science.gov (United States)

    Peter, Beatrix; Nador, Judit; Juhasz, Krisztina; Dobos, Agnes; Körösi, Laszlo; Székács, Inna; Patko, Daniel; Horvath, Robert

    2015-06-01

    The in situ observation of cell movements and morphological parameters over longer periods of time under physiological conditions is critical in basic cell research and biomedical applications. The quantitative phase-contrast microscope applied in this study has a remarkably small size, therefore it can be placed directly into a humidified incubator. Here, we report on the successful application of this M4 Holomonitor to observe cancer cell motility, motility speed, and migration in the presence of the green tea polyphenol, epigallocatechin gallate, as well as to monitor the adhesion of preosteoblast cells on nanostructured titanate coatings, relevant for biomedical applications. A special mechanical stage was developed to position the sample into that range of the optical arrangement where digital autofocusing works with high reproducibility and precision. By in-depth analyzing the obtained single cell morphological parameters, we show that the limited vertical resolution of the optical setup results in underestimated single cell contact area and volume and overestimated single cell averaged thickness. We propose a simple model to correct the recorded data to obtain more precise single cell parameters. We compare the results with the kinetic data recorded by a surface sensitive optical biosensor, optical waveguide lightmode spectroscopy.

  16. Design of multi-parameter device for marine environment monitoring%多参数海洋环境监测装置的设计

    Institute of Scientific and Technical Information of China (English)

    张礼杰; 殷建军; 项祖丰; 汤健彬

    2011-01-01

    A set of multi-parameter marine environment testing devices is designed. Its processor is low consumption ARM7 processor S3C44B0. Several intelligent sensors are extended by the I2C bus. In order to improve the precision of the analog sensor, the digital filtering method is used to deal with the data collected. In iridium satellite communication process,data calibration method and data encryption method are used to reduce the false code rate probability and improve the data security. Simulation experiment is carried out in laboratory environment,the results show that the system works reliably,and analog sensor has satisfied precision.%设计一种多参数海洋环境检测装置,采用低功耗的ARM7系列的S3C44B0作为主处理器,采用I2C总线扩展多个智能传感器.为了提高模拟传感器的精度,采用数字滤波方法处理采集到的数据.在铱星通信过程中采用数据校验的方法和数据加密的方法,降低了数据的误码率和提高了数据的安全性.在实验室的环境下进行模拟实验,结果表明:系统工作可靠,并且模拟传感器具有很好的测量精度.

  17. Aerodynamics and Heat Transfer Studies of Parameters Specific to the IGCC-Requirements: Endwall Contouring, Leading Edge and Blade Tip Ejection under Rotating Turbine Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Schobeiri, Meinhard; Han, Je-Chin

    2014-09-30

    This report deals with the specific aerodynamics and heat transfer problematic inherent to high pressure (HP) turbine sections of IGCC-gas turbines. Issues of primary relevance to a turbine stage operating in an IGCC-environment are: (1) decreasing the strength of the secondary flow vortices at the hub and tip regions to reduce (a), the secondary flow losses and (b), the potential for end wall deposition, erosion and corrosion due to secondary flow driven migration of gas flow particles to the hub and tip regions, (2) providing a robust film cooling technology at the hub and that sustains high cooling effectiveness less sensitive to deposition, (3) investigating the impact of blade tip geometry on film cooling effectiveness. The document includes numerical and experimental investigations of above issues. The experimental investigations were performed in the three-stage multi-purpose turbine research facility at the Turbomachinery Performance and Flow Research Laboratory (TPFL), Texas A&M University. For the numerical investigations a commercial Navier-Stokes solver was utilized.

  18. The effect of different adjuvants on immune parameters and protection following vaccination of sheep with a larval-specific antigen of the gastrointestinal nematode, Haemonchus contortus.

    Directory of Open Access Journals (Sweden)

    David Piedrafita

    Full Text Available It has recently been recognised that vaccine adjuvants play a critical role in directing the nature of a vaccine induced effector response. In the present study, several adjuvants were evaluated for their ability to protect sheep after field vaccination with the larval-specific Haemonchus contortus antigen, HcsL3. Using a suboptimal antigen dose, aluminium adjuvant was shown to reduce the cumulative faecal egg counts (cFEC and worm burden by 23% and 25% respectively, in agreement with a previous study. The addition of Quil A to the aluminium-adjuvanted vaccine brought cFEC back to control levels. Vaccination with the adjuvant DEAE-dextran almost doubled the protection compared to the aluminium-adjuvanted vaccine resulting in 40% and 41% reduction in cFEC and worm counts compared to controls. Examination of skin responses following i.d. injection of exsheathed L3, revealed that cFEC was negatively correlated with wheal size and tissue eosinophils for the DEAE-dextran and aluminium-adjuvanted groups respectively. These studies have for the first time shown the potential of DEAE-dextran adjuvant for helminth vaccines, and discovered significant cellular correlates of vaccine-induced protection.

  19. Design and Implementation of a Certain Self-propelled Anti-aircraft Gun Floating Parameter Monitoring System%某自行高炮浮动参数监测系统的设计与实现

    Institute of Scientific and Technical Information of China (English)

    孙致远; 郑坚; 熊超; 殷军辉

    2016-01-01

    为了能够实时掌握自行高炮自动机性能,提高装备的可靠性,利用无线传感器网络技术,设计并建立了自行高炮浮动参数监测系统。该监测系统利用磁致伸缩位移传感器,实现了后坐位移的精确测量;设计了一种具有高速采集和片上处理功能的无线传感器网络节点,实现了数据的采集、储存与无线传输;开发了上位机软件,能够根据回传数据,完成后坐曲线的显示和浮动参数的自动提取。实弹测试试验表明,该监测系统能够基本满足自行高炮浮动参数在线监测的要求。%For the purpose of keeping track of the performance of the auto-mechanism of self-propelled anti-aircraft gun and improve its reliability,the floating parameter monitoring system of self-propelled anti-aircraft gun was designed and established based on the wireless sensor networks (WSNs)technolo-gy. In the monitoring system,the magnetostriction displacement sensors were used to successfully and accurately pick up the recoil displacement. A WSN node with high speed acquisition and on-chip pro-cessing was designed to realize the data collection,storage and wireless transmission. The host compu-ter software was designed to achieve the recoil curve display and the floating parameter automation ex-traction according to the data received. The firing test shows that the system can basically satisfy the floating parameter on-line monitoring requirement.

  20. On-field monitoring of fruit ripening evolution and quality parameters in olive mutants using a portable NIR-AOTF device.

    Science.gov (United States)

    Cirilli, Marco; Bellincontro, Andrea; Urbani, Stefania; Servili, Maurizio; Esposto, Sonia; Mencarelli, Fabio; Muleo, Rosario

    2016-05-15

    This study optimizes the application of portable Near Infrared-Acousto Optically Tunable Filter (NIR) device to meet the increasing demand for cost-effective, non-invasive and easy-to-use methods for measuring physical and chemical properties during olive fruit development. Fruits from different phenotypically cultivars were sampled for firmness, total and specific phenols detection by HPLC, total anthocyanins, chlorophyll and carotenoids detection by spectrophotometry. On the same fruits, a portable NIR device in diffuse reflectance mode was employed for spectral detections. Predictive models for firmness, chlorophyll, anthocyanins, carotenoids and rutin were developed by Partial Least Square analysis. Oleuropein, verbascoside, 3,4-DHPEA-EDA, and total phenols were used to develop a validation model. Internal cross-validation was applied for calibration and predictive models. The standard errors for calibration, cross-validation, prediction, and RPD ratios (SD/SECV) were calculated as references for the model effectiveness. The determination of the optimal harvesting time facilitates the production of high quality extra virgin olive oil and table olives.

  1. Towards innovative roadside monitoring

    Science.gov (United States)

    Ojha, G.; Appel, E.; Magiera, T.

    2012-04-01

    Soil contamination along roadsides is an important factor of anthropogenic point source pollution. Climatic and traffic-specific factors influence the amount and characteristics of pollution emitted and deposited in the roadside soil. In our present study we focus on monitoring typical traffic pollutants (heavy metals HM, platinum group elements, polycyclic hydrocarbons PAH), and investigate the use of magnetic parameters, especially magnetic susceptibility (MS) as proxy. Monitoring plots were installed along roadside in areas with different climatic conditions and different traffic-specific activities (traffic density and speed, vehicle types, abrasion of tires, brake linings, petrol/diesel compounds and road maintenance). For