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Sample records for monitoring project mmp

  1. Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression

    Directory of Open Access Journals (Sweden)

    Sonia Pahwa

    2014-02-01

    Full Text Available Membrane-type 1 matrix metalloproteinase (MT1-MMP is a zinc-dependent type-I transmembrane metalloproteinase involved in pericellular proteolysis, migration and invasion. Numerous substrates and binding partners have been identified for MT1-MMP, and its role in collagenolysis appears crucial for tumor invasion. However, development of MT1-MMP inhibitors must consider the substantial functions of MT1-MMP in normal physiology and disease prevention. The present review examines the plethora of MT1-MMP activities, how these activities relate to cancer initiation and progression, and how they can be monitored in real time. Examination of MT1-MMP activities and cell surface behaviors can set the stage for the development of unique, selective MT1-MMP inhibitors.

  2. Flight Systems Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I project will develop the Flight System Monitor which will use non-intrusive electrical monitoring (NEMO). The electronic system health of...

  3. Spacecraft Power Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I project will develop the Spacecraft Power Monitor (SPM) which will use non-intrusive electrical monitoring (NEMO). NEMO transforms the power...

  4. Aerospace Systems Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Proposal Title: Aerospace Systems Monitor PHASE 1 Technical Abstract: This Phase II STTR project will continue development and commercialization of the Aerospace...

  5. Aerospace Systems Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I STTR project will demonstrate the Aerospace System Monitor (ASM). This technology transforms the power distribution network in a spacecraft or aircraft...

  6. Statistical process monitoring based on orthogonal multi-manifold projections and a novel variable contribution analysis.

    Science.gov (United States)

    Tong, Chudong; Shi, Xuhua; Lan, Ting

    2016-11-01

    Multivariate statistical methods have been widely applied to develop data-based process monitoring models. Recently, a multi-manifold projections (MMP) algorithm was proposed for modeling and monitoring chemical industrial processes, the MMP is an effective tool for preserving the global and local geometric structure of the original data space in the reduced feature subspace, but it does not provide orthogonal basis functions for data reconstruction. Recognition of this issue, an improved version of MMP algorithm named orthogonal MMP (OMMP) is formulated. Based on the OMMP model, a further processing step and a different monitoring index are proposed to model and monitor the variation in the residual subspace. Additionally, a novel variable contribution analysis is presented for fault diagnosis by integrating the nearest in-control neighbor calculation and reconstruction-based contribution analysis. The validity and superiority of the proposed fault detection and diagnosis strategy are then validated through case studies on the Tennessee Eastman benchmark process.

  7. PENGARUH MODEL MISSOURI MATHEMATICS PROJECT (MMP TERHADAP KEMAMPUAN PEMAHAMAN DAN PEMECAHAN MASALAH MATEMATIKA SISWA SMA N I LUBUKLINGGAU

    Directory of Open Access Journals (Sweden)

    Anna Fauziah

    2015-02-01

    Full Text Available ABSTRAK   Penelitian ini betujuan untuk mengetahui pengaruh model Missouri Mathematics Project (MMP pada kemampuan pemahaman dan pemecahan masalah matematika siswa, serta mengetahui hubungan antara kemampuan pemahaman dan pemecahan masalah matematika siswa SMA N 1 Lubuklinggau. Desain penelitian ini adalah randomized pretest-postest control group design. Instrumen yang digunakan adalah tes kemampuan pemahaman dan tes  kemampuan pemecahan masalah matematika siswa. Analisis dilakukan secara kuantitatif. Hasil penelitian menunjukkan bahwa (1 Model MMP tidak berpengaruh secara signifikan terhadap kemampuan pemahaman matematika siswa; (2 Model MMP berpengaruh secara signifikan terhadap kemampuan pemecahan masalah matematika siswa; (3 Terdapat hubungan/keterkaitan antara kemampuan pemhaman dan pemecahan masalah matematika siswa.   Kata Kunci    :   Model Missouri Mathematics Project, pemahaman, pemecahan masalah matematika     ABSTRACT This study aims to determine the effect models Missouri Mathematics Project (MMP the ability of understanding and solving mathematical problems of students, and to know the relationship between the ability of understanding and solving mathematical problems students SMA N 1 Lubuklinggau. The study design was a randomized pretest-posttest control group design. The instrument used was the test the ability of comprehension and test students' mathematical problem solving ability. Analyses were performed quantitatively. The results showed that (1 Model MMP does not significantly affect the ability of students' understanding of mathematics; (2 Model MMP significantly affect students' mathematical problem solving abilities; (3 There is a relationship / linkages between pemhaman ability and problem solving math students.   Keywords:        Model Missouri Mathematics Project, comprehension, mathematical problem solving

  8. Lunar Health Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — During the Phase II Lunar Health Monitor program, Orbital Research will develop a second generation wearable sensor suite for astronaut physiologic monitoring. The...

  9. Lunar Health Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Orbital Research has successfully demonstrated a dry electrode (no electrolyte or gel required) for heart rate and ECG monitoring. Preliminary data has indicated...

  10. Multispectral Particle Absorption Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovation Research Phase II project concerns the development of a multi-wavelength monitor that will provide rapid, real-time measurement of the...

  11. Multispectral Particle Absorption Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovation Research Phase I project concerns the development of a multi-wavelength monitor that will provide rapid, real-time measurement of the...

  12. Islay LIMPET project monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Heath, T.

    2002-07-01

    Wavegen was contracted by the DTI as part of its Sustainable Energy Programmes to monitor and report on the final stages of the construction, installation of turbo-generation equipment, commissioning and operation of the LIMPET wave energy system. The report discusses the choice of technology, where the system was installed, power take off, construction of the collector, installation of the turbo-generator, maintenance, operation, management and planning issues. The performance of the system was found to be poorer than expected and the reasons for this were identified. The main conclusions were that the system is sufficiently robust to operate in the marine environment and downtimes are expected to be short.

  13. Media Performance in South Africa: A Shift from Vertical to Horizontal Monitoring.

    Science.gov (United States)

    van Zyl, John; Kantor, Lara

    1995-01-01

    Discusses the Media Monitoring Project (MMP) of South Africa, an organization that monitored the media ahead of and during South Africa's first democratic elections. Describes the MMP's roots and its activities and impact before, during, and after the election. (SR)

  14. Southern Fine Particulate Monitoring Project

    Energy Technology Data Exchange (ETDEWEB)

    Ashley Williamson

    2003-05-31

    This final project report presents experimental details, results and analysis of continuous onsite ambient fine particulate data at the North Birmingham sampling site during the October, 2001-September, 2002 study period.The host site for these measurement activities is the North Birmingham PM monitoring station by the Jefferson County Health Department in Birmingham, AL.The continuous data include PM{sub 2.5} mass concentrations measured by TEOM, particle sulfate using the R&P 8400S monitor, particle size distributions measured by SMPS and APS monitors, and PM{sub 2.5} light scattering extinction coefficient as measured by nephelometer. During the course of the project, measurement intercomparison data were developed for these instruments and several complementary measurements at the site. The report details the instrument set and operating procedures and describes the resulting data. Report subsections present an overview summary of the data, followed by detailed description of the systematic time behavior of PM{sub 2.5} and other specific particulate size fractions. Specific subsections are included for particle size distribution, light scattering, and particle sulfate data. The final subsection addresses application of the measurements to the practical questions of fine PM generation and transport, source attribution, and PM{sub 2.5} management strategies.

  15. Integrated monitoring plan for the Hanford groundwater monitoring project

    Energy Technology Data Exchange (ETDEWEB)

    Hartman, M.J.; Dresel, P.E.; McDonald, J.P.; Mercer, R.B.; Newcomer, D.R.; Thornton, E.C.

    1998-09-01

    Groundwater is monitored in hundreds of wells at the Hanford Site to fulfill a variety of requirements. Separate monitoring plans are prepared for various requirements, but sampling is coordinated and data are shared among users to avoid duplication of effort. The US Department of Energy (DOE) manages these activities through the Hanford Groundwater Monitoring Project (groundwater project), which is the responsibility of Pacific Northwest National Laboratory. The groundwater project does not include all of the monitoring to assess performance of groundwater remediation or all monitoring associated with active facilities. This document is the first integrated monitoring plan for the groundwater project and contains: well and constituent lists for monitoring required by the Atomic Energy Act of 1954 and its implementing orders; other, established monitoring plans by reference; and a master well/constituent/frequency matrix for the entire Hanford Site.

  16. BPA genetic monitoring - BPA Genetic Monitoring Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Initiated in 1989, this study monitors genetic changes associated with hatchery propagation in multiple Snake River sub-basins for Chinook salmon and steelhead. We...

  17. Adverse event detection, monitoring, and evaluation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR project delivers a single-sensor structural health-monitoring (SHM) system that uses the impedance method to monitor structural integrity, wave propagation...

  18. Volunteers for Air Monitoring Project (VAMP).

    Science.gov (United States)

    Oak Ridge National Lab., TN.

    An education and communication project of the Environment and Technology Assessment Program, Oak Ridge National Laboratory, Tennessee, is described in this report. The project for monitoring air dustfall resulted in the largest citizen-scientist air monitoring effort in the history of our nation. Nearly 21,000 public secondary school students and…

  19. Spacecraft Cabin Particulate Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to design, build and test an optical extinction monitor for the detection of spacecraft cabin particulates. This monitor will be sensitive to particle...

  20. Wearable Health Monitoring Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this proposal is to demonstrate the feasibility of producing a wearable health monitoring system for the human body that is functional, comfortable,...

  1. Spacecraft Cabin Particulate Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We have built and tested an optical extinction monitor for the detection of spacecraft cabin particulates. This sensor sensitive to particle sizes ranging from a few...

  2. Crew Cerebral Oxygen Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase II SBIR proposal is aimed at developing a non-invasive, optical method for monitoring crew member state of awareness in operational environments. All...

  3. Crew Cerebral Oxygen Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I SBIR proposal is aimed at developing a non-invasive, optical method for monitoring the state of consciousness of crew members in operational...

  4. Wearable Health Monitoring Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this proposal is to demonstrate the feasibility of producing a wearable health monitoring system for the human body that is functional, comfortable,...

  5. Monitoring the effectiveness evaluation of investment projects

    Directory of Open Access Journals (Sweden)

    Skopin Alex O.

    2012-02-01

    Full Text Available The article raised the question of monitoring regulatory evaluation of the effectiveness of regional investment projects. This is justified by the fact that the current regulatory framework defined indicators for measuring the effectiveness of regional investment projects, but these figures are usually used only at the design stage of the project, an interim assessment of the effectiveness of a sufficiently simplified and based on the level of exploration investment.

  6. Introduction to Meridian Space Weather Monitoring Project

    Institute of Scientific and Technical Information of China (English)

    WU Ji; WANG Chi; FAN Quanlin

    2006-01-01

    The Meridian Project is a ground- based network program to monitor solar-terrestrial space environment, which consists of a chain of ground-based observatories with multiple instruments including magnetometers, ionosondes, HF and VHF radar, Lidar, IPS monitors, sounding rockets etc. The chain is mainly located in the neighborhood of 120°E meridian, and is thus named the Meridian Project. It has officially been approved by the Chinese government and will be finished by 2009. This talk will give an overview of the Meridian Project and the proposed International Space Weather Meridian Circle Program.

  7. Project Monitoring and Control Measures In CMMI

    Directory of Open Access Journals (Sweden)

    Mahmoud Khraiwesh

    2013-10-01

    Full Text Available Project monitoring and control process is an important process in developing any computer informationsystem. Monitoring and Control provides an understanding of the project’s progress so that when theproject deviates significantly from the plan appropriate corrective actions can be taken. This research willidentify general measures for the specific goals and its specific practices of Project Monitoring andControl Process Area in Capability Maturity Model Integration (CMMI. CMMI is developed in USA bySoftware Engineering Institute (SEI in Carnegie Mellon University. CMMI is a framework for assessmentand improvement of computer information systems. The procedure we used to determine the measures is toapply the Goal Questions Metrics (GQM approach to the two specific goals and its ten specific practicesof Project Monitoring and Control Process Area in CMMI.

  8. SOUTHERN FINE PARTICULATE MONITORING PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2002-04-01

    This quarterly report presents results and analysis of continuous onsite ambient fine particulate data at the North Birmingham sampling site during the January-March, 2002 study period. The continuous data include PM{sub 2.5} mass concentrations measured by TEOM, particle sulfate using the R&P 8400S monitor, particle size distributions measured by SMPS and APS monitors, and PM{sub 2.5} light scattering extinction coefficient as measured by nephelometer. Some instrumental issues were noted with the upgrade of the APS model 3320 are described in the report, as well as preliminary performance indications for the upgraded instrument. During the quarter preliminary data analysis and modeling studies were conducted to test the potential of the North Birmingham site data for source attribution analyses. Our initial assessment has continued to be optimistic in this regard due to the location of the site relative to several important classes of local and midrange emission sources. We anticipate that these analyses will provide good separations of the effects of major source classes and spatial source clusters, and will provide useful information relevant to PM{sub 2.5} implementation strategies.

  9. Stream restoration and enhancement projects: is anyone monitoring?

    Science.gov (United States)

    Bash, Jeffrey S; Ryan, Clare M

    2002-06-01

    Declines in salmon stocks and general watershed health in Washington State, USA, have led to an increase in stream restoration and enhancement projects initiated throughout the state. The increasing number of projects has also raised questions regarding the monitoring of these efforts. Project managers receiving hydraulic project approvals (HPAs) were surveyed to determine whether monitoring was taking place on their projects. About half the project managers surveyed reported the collection of baseline data and the use of biological, physical, chemical, or other water quality measures for their projects. Of those who reported collection of monitoring data, only 18% indicated that monitoring was required. Respondents were also asked to rank the importance of various project goals on a Likert scale. Project managers with projects focusing on "engineering" goals (e.g., roadbed stabilization) were less likely than other project managers to collect baseline monitoring data. Project managers with projects focusing on "restoration/ecological" or "fisheries" goals were more likely than other project managers to collect monitoring measures. Although monitoring appears to be taking place in slightly more than half of the projects surveyed, the nature of the data collected varies widely across projects, and in most cases the monitoring effort is voluntary. This suggests that project sponsors, funders, and managers must consider the issues involved in requiring appropriate monitoring, establishing standardized monitoring guidelines, the time frames in which to monitor, providing other incentives for conducting monitoring, and ensuring adequate funding for monitoring efforts.

  10. Monitored Geologic Repository Project Description Document

    Energy Technology Data Exchange (ETDEWEB)

    P. M. Curry

    2001-01-30

    The primary objective of the Monitored Geologic Repository Project Description Document (PDD) is to allocate the functions, requirements, and assumptions to the systems at Level 5 of the Civilian Radioactive Waste Management System (CRWMS) architecture identified in Section 4. It provides traceability of the requirements to those contained in Section 3 of the ''Monitored Geologic Repository Requirements Document'' (MGR RD) (YMP 2000a) and other higher-level requirements documents. In addition, the PDD allocates design related assumptions to work products of non-design organizations. The document provides Monitored Geologic Repository (MGR) technical requirements in support of design and performance assessment in preparing for the Site Recommendation (SR) and License Application (LA) milestones. The technical requirements documented in the PDD are to be captured in the System Description Documents (SDDs) which address each of the systems at Level 5 of the CRWMS architecture. The design engineers obtain the technical requirements from the SDDs and by reference from the SDDs to the PDD. The design organizations and other organizations will obtain design related assumptions directly from the PDD. These organizations may establish additional assumptions for their individual activities, but such assumptions are not to conflict with the assumptions in the PDD. The PDD will serve as the primary link between the technical requirements captured in the SDDs and the design requirements captured in US Department of Energy (DOE) documents. The approved PDD is placed under Level 3 baseline control by the CRWMS Management and Operating Contractor (M and O) and the following portions of the PDD constitute the Technical Design Baseline for the MGR: the design characteristics listed in Table 1-1, the MGR Architecture (Section 4.1), the Technical Requirements (Section 5), and the Controlled Project Assumptions (Section 6).

  11. A Cryosphere Monitoring Project in the Himalayas

    Science.gov (United States)

    Stumm, D.; Mool, P. K.; Shresta, A. B.; Joshi, S. P.; Bajracharya, S. R.; Kayastha, R. B.; Devkota, L. P.; Bajracharya, O. R.

    2011-12-01

    The Cryosphere Monitoring Project (CMP) has been initiated by ICIMOD (International Centre for Integrated Mountain Development) with the aim to gain more knowledge about the cryosphere in the Himalayas and to build capacities in Nepalese organisations. The CMP is carried out in collaboration with the Kathmandu University, Tribhuvan University, the Department of Hydrology and Meteorology and the Water and Energy Commission Secretariat, and is sponsored by the Royal Norwegian Embassy. The CMP has a multilevel and integrative approach and consists of the following five components: (1) glacier monitoring, (2) assessment of current and future water resources at catchment and sub-basin scale, (3) multi-level remote sensing based observations for glacier and snow monitoring, (4) strengthening ICIMOD as regional knowledge hub for cryospheric information, (5) capacity building of Nepalese organisations. The glacier monitoring component includes field-based mass balance, geometry and glacier flow measurements on two clean and one debris-covered glacier and their analysis, as well as snow cover measurements. The in-situ glacier measurements promote process understanding, provide a refined temporal resolution of mass balance data and data for calibration of glacio-hydrological models. To assess current water resources, meteorological and hydrological measurements are initiated and the run-off is calculated with glacio-hydrological and snow-melt models for the catchments of the selected glaciers. Future water availability will be assessed by down-scaling regional climate model (RCM) data that is applied to the glacio-hydrological model. Remote sensing data is used to improve spatial information about the glacier distribution by refining glacier inventories, and to calculate the geodetic mass balance for the selected glaciers to complement the directly measured glacier mass balance. Additionally, the operation of a MODIS satellite receiving station is planned to obtain near real

  12. Integrated monitoring and surveillance system demonstration project

    Energy Technology Data Exchange (ETDEWEB)

    Aumeier, S.E.; Walters, G. [Argonne National Lab., Idaho Falls, ID (United States); Kotter, D.; Walrath, W.M.; Zamecnik, R.J. [Lockheed-Martin Idaho Technologies Company, Idaho Falls, ID (United States)

    1997-07-01

    We present a summary of efforts associated with the installation of an integrated system for the surveillance and monitoring of stabilized plutonium metals and oxides in long-term storage. The product of this effort will include a Pu storage requirements document, baseline integrated monitoring and surveillance system (IMSS) prototype and test bed that will be installed in the Fuel Manufacturing Facility (FMF) nuclear material vault at Argonne National Laboratory - West (ANL-W), and a Pu tracking database including data analysis capabilities. The prototype will be based on a minimal set of vault and package monitoring requirements as derived from applicable DOE documentation and guidelines, detailed in the requirements document, including DOE-STD-3013-96. The use of standardized requirements will aid individual sites in the selection of sensors that best suit their needs while the prototype IMSS, located at ANL-W, will be used as a test bed to compare and contrast sensor performance against a baseline integrated system (the IMSS), demonstrate system capabilities, evaluate potential technology gaps, and test new hardware and software designs using various storage configurations. With efforts currently underway to repackage and store a substantial quantity of plutonium and plutonium-bearing material within the DOE complex, this is an opportune time to undertake such a project. 4 refs.

  13. Monitored Geologic Repository Project Description Document

    Energy Technology Data Exchange (ETDEWEB)

    P. Curry

    2001-06-26

    The primary objective of the Monitored Geologic Repository Project Description Document (PDD) is to allocate the functions, requirements, and assumptions to the systems at Level 5 of the Civilian Radioactive Waste Management System (CRWMS) architecture identified in Section 4. It provides traceability of the requirements to those contained in Section 3 of the Yucca Mountain Site Characterization Project Requirements Document (YMP RD) (YMP 2001a) and other higher-level requirements documents. In addition, the PDD allocates design related assumptions to work products of non-design organizations. The document provides Monitored Geologic Repository (MGR) technical requirements in support of design and performance assessment in preparing for the Site Recommendation (SR) and License Application (LA) milestones. The technical requirements documented in the PDD are to be captured in the System Description Documents (SDDs) which address each of the systems at Level 5 of the CRWMS architecture. The design engineers obtain the technical requirements from the SDDs and by reference from the SDDs to the PDD. The design organizations and other organizations will obtain design related assumptions directly from the PDD. These organizations may establish additional assumptions for their individual activities, but such assumptions are not to conflict with the assumptions in the PDD. The PDD will serve as the primary link between the technical requirements captured in the SDDs and the design requirements captured in US Department of Energy (DOE) documents. The approved PDD is placed under Level 3 baseline control by the CRWMS Management and Operating Contractor (M&O) and the following portions of the PDD constitute the Technical Design Baseline for the MGR: the design characteristics listed in Table 1-1, the MGR Architecture (Section 4.1), the Technical Requirements (Section 5), and the Controlled Project Assumptions (Section 6).

  14. Three-Dimensional Health Monitoring of Sandwich Composites Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR project delivers a single-chip structural health-monitoring (SHM) system that uses the impedance method to monitor bulk interiors and wave propagation...

  15. Project Design Concept for Monitoring and Control System

    Energy Technology Data Exchange (ETDEWEB)

    MCGREW, D.L.

    2000-10-02

    This Project Design Concept represents operational requirements established for use in design the tank farm Monitoring and Control System. These upgrades are included within the scope of Project W-314, Tank Farm Restoration and Safe Operations.

  16. Ion Mobility Spectrometry for Water Monitoring Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Current water quality monitors aboard the International Space Station (ISS) are specialized and provide limited data. The Colorimetric Water Quality Monitor Kit...

  17. Browns Park National Wildlife Refuge monitoring projects

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This project report summarizes the projects conducted at BPNWR between 2005- 2010. At the end of this report is a list of all of the project deliverables. These...

  18. 28 CFR 512.17 - Monitoring approved research projects.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Monitoring approved research projects. 512.17 Section 512.17 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE GENERAL MANAGEMENT AND ADMINISTRATION RESEARCH Research § 512.17 Monitoring approved research projects. The...

  19. FY 2002 Integrated Monitoring Plan for the Hanford Groundwater Monitoring Project

    Energy Technology Data Exchange (ETDEWEB)

    Hartman, Mary J.; Dresel, P Evan; Lindberg, Jonathan W.; Newcomer, Darrell R.; Thornton, Edward C.

    2001-10-31

    This document is an integrated monitoring plan for the groundwater project and contains: well and constituent lists for monitoring required by the Atomic Energy Act of 1954 and its implementing orders ("surveillance monitoring"); other, established monitoring plans by reference; and a master well/ constituent/frequency matrix for the entire Hanford Site.

  20. Monitoring in educational development projects : the development of a monitoring system

    NARCIS (Netherlands)

    Plomp, Tjeerd; Huijsman, Hari; Kluyfhout, Eric

    1992-01-01

    Monitoring in education is usually focused on the monitoring of educational systems at different levels. Monitoring of educational projects receives only recently explicit attention. The paper discusses first the concepts of educational monitoring and evaluation. After that, the experience with deve

  1. Tools for Monitoring Social Media: A Marketing Research Project

    Science.gov (United States)

    Veeck, Ann; Hoger, Beth

    2014-01-01

    Knowledge of how to effectively monitor social media is an increasingly valued marketing research skill. This study tests an approach for adding social media content to an undergraduate marketing research class team project. The revised project maintains the expected objectives and parameters of a traditional research project, while integrating…

  2. Tools for Monitoring Social Media: A Marketing Research Project

    Science.gov (United States)

    Veeck, Ann; Hoger, Beth

    2014-01-01

    Knowledge of how to effectively monitor social media is an increasingly valued marketing research skill. This study tests an approach for adding social media content to an undergraduate marketing research class team project. The revised project maintains the expected objectives and parameters of a traditional research project, while integrating…

  3. Quality Assurance Project Plan for Facility Effluent Monitoring Plan activities

    Energy Technology Data Exchange (ETDEWEB)

    Frazier, T.P.

    1994-10-20

    This Quality Assurance Project Plan addresses the quality assurance requirements for the activities associated with the Facility Effluent Monitoring Plans, which are part of the overall Hanford Site Environmental Protection Plan. This plan specifically applies to the sampling and analysis activities and continuous monitoring performed for all Facility Effluent Monitoring Plan activities conducted by Westinghouse Hanford Company. It is generic in approach and will be implemented in conjunction with the specific requirements of the individual Facility Effluent Monitoring Plans.

  4. Evolutionary Autonomous Health Monitoring System (EAHMS) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — For supporting NASA's Robotics, Tele-Robotics and Autonomous Systems Roadmap, we are proposing the "Evolutionary Autonomous Health Monitoring System" (EAHMS) for...

  5. Electronic Health Monitoring for Space Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Prognostic monitoring capabilities for space exploration aircrafts are crucial to enable safety and reliability in these platforms. Nokomis proposes to develop and...

  6. Bayesian-based Project Monitoring: Framework Development and Model Testing

    Directory of Open Access Journals (Sweden)

    Budi Hartono

    2015-12-01

    Full Text Available During project implementation, risk becomes an integral part of project monitoring. Therefore. a tool that could dynamically include elements of risk in project progress monitoring is needed. This objective of this study is to develop a general framework that addresses such a concern. The developed framework consists of three interrelated major building blocks, namely: Risk Register (RR, Bayesian Network (BN, and Project Time Networks (PTN for dynamic project monitoring. RR is used to list and to categorize identified project risks. PTN is utilized for modeling the relationship between project activities. BN is used to reflect the interdependence among risk factors and to bridge RR and PTN. A residential development project is chosen as a working example and the result shows that the proposed framework has been successfully applied. The specific model of the development project is also successfully developed and is used to monitor the project progress. It is shown in this study that the proposed BN-based model provides superior performance in terms of forecast accuracy compared to the extant models.

  7. Visual Intelligent Robot Performance Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop a Visual Intelligent Robot Performance Monitor (VIRPM) that will help crew members maintain situation awareness of robot performance more...

  8. Compact, High Accuracy CO2 Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovative Research Phase II proposal seeks to develop a low cost, robust, highly precise and accurate CO2 monitoring system. This system will...

  9. Differential Photoacoustic Particle Absorption Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop a highly sensitive and compact monitor to measure light absorption from particulate matters. The fundamental of the proposed device is based on...

  10. Three Color Particle Optical Extinction Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to design, build and test a multi-color (red, green, blue) particle optical extinction monitor suitable for use in either land or airborne applications....

  11. Compact, High Accuracy CO2 Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovative Research Phase I proposal seeks to develop a low cost, robust, highly precise and accurate CO2 monitoring system. This system will...

  12. Community air monitoring and Village Green Project

    Science.gov (United States)

    Cost and logistics are practical issues that have historically constrained the number of locations where long-term, active air pollution measurement is possible. In addition, traditional air monitoring approaches are generally conducted by technical experts with limited engageme...

  13. Acoustic Monitoring for Spaceflight Vehicle Applications Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR will develop and demonstrate acoustic sensor technology enabling real-time, remotely performed measuring and monitoring of sound pressure levels and noise...

  14. Dynamic Strain and Crack Monitoring Sensor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The development of condition-based monitoring sensor network systems has the potential to provide an enhanced aircraft safety by real time assessment of the...

  15. Dynamic Strain and Crack Monitoring Sensor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Los Gatos Research proposes to develop a new automated vehicle health monitoring sensor system capable of measuring loads and detecting crack, corrosion, and...

  16. Project W-420 Stack Monitoring system upgrades conceptual design report

    Energy Technology Data Exchange (ETDEWEB)

    TUCK, J.A.

    1998-11-06

    This document describes the scope, justification, conceptual design, and performance of Project W-420 stack monitoring system upgrades on six NESHAP-designated, Hanford Tank Farms ventilation exhaust stacks.

  17. South Bay Salt Pond Restoration Project : Phase 1 monitoring plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This SBSP Restoration Project Monitoring Plan provides methods to document the effect of restoration on important elements such as mercury uptake, and water and...

  18. Metro Multnomah Wetlands - Multnomah Channel Wetland Restoration Monitoring Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Multnomah Channel Wetland Restoration Monitoring Project characterizes wetlands use by juvenile salmonids and other fishes in the Multnomah Channel Marsh Natural...

  19. Skagit IMW - Skagit River Estuary Intensively Monitored Watershed Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This study evaluates system-level effects of several estuary restoration projects on juvenile Chinook salmon production in the Skagit River estuary. The monitoring...

  20. Crucial Component Damage Detection, Monitoring and Mitigation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR project delivers an on-board structural health-monitoring (SHM) system with embedded sensors that sense mechanical impedance deviations to flag incipient...

  1. Composite Structure Monitoring using Direct Write Sensors Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This NASA SBIR Phase II project seeks to develop and demonstrate a suite of sensor products to monitor the health of composite structures. Sensors will be made using...

  2. Walnut Creek Watershed Restoration and Water Quality Monitoring Project

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The primary objective of this project is to establish a nonpoint source monitoring program in relation to the watershed habitat restoration and agricultural...

  3. AFSC/ABL: Southeast Coastal Monitoring Project - CTD database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Southeast Alaska Coastal Monitoring (SECM) project in Alaska was initiated in 1997 by the Auke Bay Laboratory, National Marine Fisheries Service, to study the...

  4. Welcome to the Walnut Creek Nonbreeding Bird Monitoring Project

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This is a summary of the bird monitoring project at Walnut Creek National Wildlife Refuge (Neal Smith National Wildlife Refuge). The refuge is divided into 28...

  5. Quality Assurance Project Plan for Facility Effluent Monitoring Plan activities

    Energy Technology Data Exchange (ETDEWEB)

    Nickels, J.M.

    1991-06-01

    This Quality Assurance Project Plan addresses the quality assurance requirements for the Facility Monitoring Plans of the overall site-wide environmental monitoring plan. This plan specifically applies to the sampling and analysis activities and continuous monitoring performed for all Facility Effluent Monitoring Plan activities conducted by Westinghouse Hanford Company. It is generic in approach and will be implemented in conjunction with the specific requirements of individual Facility Effluent Monitoring Plans. This document is intended to be a basic road map to the Facility Effluent Monitoring Plan documents (i.e., the guidance document for preparing Facility Effluent Monitoring Plans, Facility Effluent Monitoring Plan determinations, management plan, and Facility Effluent Monitoring Plans). The implementing procedures, plans, and instructions are appropriate for the control of effluent monitoring plans requiring compliance with US Department of Energy, US Environmental Protection Agency, state, and local requirements. This Quality Assurance Project Plan contains a matrix of organizational responsibilities, procedural resources from facility or site manuals used in the Facility Effluent Monitoring Plans, and a list of the analytes of interest and analytical methods for each facility preparing a Facility Effluent Monitoring Plan. 44 refs., 1 figs., 2 tabs.

  6. Back Bay Stormwater Monitoring Project Final Report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The objective of this project was to assess the influx of nutrients and solid material into Back Bay and its tributaries during and immediately following such storm...

  7. Near-facility environmental monitoring quality assurance project plan

    Energy Technology Data Exchange (ETDEWEB)

    McKinney, S.M.

    1997-11-24

    This Quality Assurance Project Plan addresses the quality assurance requirements for the activities associated with the preoperational and near facility environmental monitoring performed by Waste Management Federal Services, Inc., Northwest Operations and supersedes WHC-EP-0538-2. This plan applies to all sampling and monitoring activities performed by waste management Federal Services, Inc., Northwest Operations in implementing facility environmental monitoring at the Hanford Site.

  8. PERMEABLE TREATMENT WALL EFFECTIVENESS MONITORING PROJECT, NEVADA STEWART MINE

    Science.gov (United States)

    This report summarizes the results of Mine Waste Technology Program (MWTP) Activity III, Project 39, Permeable Treatment Wall Effectiveness Monitoring Project, implemented and funded by the U.S. Environmental Protection Agency (EPA) and jointly administered by EPA and the U.S. De...

  9. Monitoring Completed Coastal Projects - Lessons Learned I

    Science.gov (United States)

    1992-06-01

    breakwater at Spud Point Marina, Bodega Harbor, CA was monitored. Lessons learned are: 35. Small transmitted wave heights, even on the order of a few inches...July 1988. Lott, J. W., ’Spud Point Marina Breakwater, California,’ Bodega Bay, Sonoma County, MP CERC-91-5, US Army Engineer Waterways 1991

  10. Matrix Metalloproteinase-3 (MMP-3) Is an Endogenous Activator of the MMP-9 Secreted by Placental Leukocytes: Implication in Human Labor.

    Science.gov (United States)

    Flores-Pliego, Arturo; Espejel-Nuñez, Aurora; Castillo-Castrejon, Marisol; Meraz-Cruz, Noemi; Beltran-Montoya, Jorge; Zaga-Clavellina, Veronica; Nava-Salazar, Sonia; Sanchez-Martinez, Maribel; Vadillo-Ortega, Felipe; Estrada-Gutierrez, Guadalupe

    2015-01-01

    The activity of matrix degrading enzymes plays a leading role in the rupture of the fetal membranes under normal and pathological human labor, and matrix metalloproteinase-9 (MMP-9) it is considered a biomarker of this event. To gain further insight into local MMP-9 origin and activation, in this study we analyzed the contribution of human placental leukocytes to MMP-9 secretion and explored the local mechanisms of the pro-enzyme activation. Placental blood leukocytes were obtained from women at term gestation without labor and maintained in culture up to 72 h. MMP-9 activity in the culture supernatants was determined by zymography and using a specific substrate. The presence of a potential pro-MMP-9 activator in the culture supernatants was monitored using a recombinant biotin-labeled human pro-MMP-9. To characterize the endogenous pro-MMP-9 activator, MMP-1, -3, -7 and -9 were measured by multiplex assay in the supernatants, and an inhibition assay of MMP-9 activation was performed using an anti-human MMP-3 and a specific MMP-3 inhibitor. Finally, production of MMP-9 and MMP-3 in placental leukocytes obtained from term pregnancies with and without labor was assessed by immunofluorescence. Placental leukocytes spontaneously secreted pro-MMP-9 after 24 h of culture, increasing significantly at 48 h (P≤0.05), when the active form of MMP-9 was detected. Culture supernatants activated the recombinant pro-MMP-9 showing that placental leukocytes secrete the activator. A significant increase in MMP-3 secretion by placental leukocytes was observed since 48 h in culture (P≤0.05) and up to 72 h (P≤0.001), when concentration reached its maximum value. Specific activity of MMP-9 decreased significantly (P≤0.005) when an anti-MMP-3 antibody or a specific MMP-3 inhibitor were added to the culture media. Placental leukocytes from term labor produced more MMP-9 and MMP-3 compared to term non-labor cells. In this work we confirm that placental leukocytes from human term

  11. Matrix Metalloproteinase-3 (MMP-3 Is an Endogenous Activator of the MMP-9 Secreted by Placental Leukocytes: Implication in Human Labor.

    Directory of Open Access Journals (Sweden)

    Arturo Flores-Pliego

    Full Text Available The activity of matrix degrading enzymes plays a leading role in the rupture of the fetal membranes under normal and pathological human labor, and matrix metalloproteinase-9 (MMP-9 it is considered a biomarker of this event. To gain further insight into local MMP-9 origin and activation, in this study we analyzed the contribution of human placental leukocytes to MMP-9 secretion and explored the local mechanisms of the pro-enzyme activation.Placental blood leukocytes were obtained from women at term gestation without labor and maintained in culture up to 72 h. MMP-9 activity in the culture supernatants was determined by zymography and using a specific substrate. The presence of a potential pro-MMP-9 activator in the culture supernatants was monitored using a recombinant biotin-labeled human pro-MMP-9. To characterize the endogenous pro-MMP-9 activator, MMP-1, -3, -7 and -9 were measured by multiplex assay in the supernatants, and an inhibition assay of MMP-9 activation was performed using an anti-human MMP-3 and a specific MMP-3 inhibitor. Finally, production of MMP-9 and MMP-3 in placental leukocytes obtained from term pregnancies with and without labor was assessed by immunofluorescence.Placental leukocytes spontaneously secreted pro-MMP-9 after 24 h of culture, increasing significantly at 48 h (P≤0.05, when the active form of MMP-9 was detected. Culture supernatants activated the recombinant pro-MMP-9 showing that placental leukocytes secrete the activator. A significant increase in MMP-3 secretion by placental leukocytes was observed since 48 h in culture (P≤0.05 and up to 72 h (P≤0.001, when concentration reached its maximum value. Specific activity of MMP-9 decreased significantly (P≤0.005 when an anti-MMP-3 antibody or a specific MMP-3 inhibitor were added to the culture media. Placental leukocytes from term labor produced more MMP-9 and MMP-3 compared to term non-labor cells.In this work we confirm that placental leukocytes from

  12. Healy Clean Coal Project, Healy, Alaska final Environmental Monitoring Plan

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-14

    This Environmental Monitoring Plan (EMP) provides the mechanism to evaluate the integrated coal combustion/emission control system being demonstrated by the Healy Clean Coal Project (HCCP) as part-of the third solicitation of the US Department of Energy (DOE) Clean Coal Technology Demonstration Program (CCT-III). The EMP monitoring is intended to satisfy two objectives: (1) to develop the information base necessary for identification, assessment, and mitigation of potential environmental problems arising from replication of the technology and (2) to identify and quantify project-specific and site-specific environmental impacts predicted in the National Environmental Policy Act (NEPA) documents (Environmental Impact Statement and Record of Decision). The EMP contains a description of the background and history of development of the project technologies and defines the processes that will take place in the combustion and spray dryer absorber systems, including the formation of flash-calcined material (FCM) and its use in sulfur dioxide (SO{sub 2}) removal from the flue gases. It also contains a description of the existing environmental resources of the project area. The EMP includes two types of environmental monitoring that are to be used to demonstrate the technologies of the HCCP: compliance monitoring and supplemental monitoring. Compliance monitoring activities include air emissions, wastewater effluents, and visibility. Monitoring of these resources provide the data necessary to demonstrate that the power plant can operate under the required state and federal statutes, regulations, and permit requirements.

  13. Medication monitoring and drug testing ethics project.

    Science.gov (United States)

    Payne, Richard; Moe, Jeffrey L; Sevier, Catherine Harvey; Sevier, David; Waitzkin, Michael

    2015-01-01

    In 2012, Duke University initiated a research project, funded by an unrestricted research grant from Millennium Laboratories, a drug testing company. The project focused on assessing the frequency and nature of questionable, unethical, and illegal business practices in the clinical drug testing industry and assessing the potential for establishing a business code of ethics. Laboratory leaders, clinicians, industry attorneys, ethicists, and consultants participated in the survey, were interviewed, and attended two face-to-face meetings to discuss a way forward. The study demonstrated broad acknowledgment of variations in the legal and regulatory environment, resulting in inconsistent enforcement of industry practices. Study participants expressed agreement that overtly illegal practices sometimes exist, particularly when laboratory representatives and clinicians discuss reimbursement, extent of testing, and potential business incentives with medical practitioners. Most respondents reported directly observing probable violations involving marketing materials, contracts, or, in the case of some individuals, directly soliciting people with offers of clinical supplies and other "freebies." While many study respondents were skeptical that voluntary standards alone would eliminate questionable business practices, most viewed ethics codes and credentialing as an important first step that could potentially mitigate uneven enforcement, while improving quality of care and facilitating preferred payment options for credentialed parties. Many were willing to participate in future discussions and industry-wide initiatives to improve the environment.

  14. Project management metrics, KPIs, and dashboards a guide to measuring and monitoring project performance

    CERN Document Server

    Kerzner, Harold

    2013-01-01

    Today, with the growth of complex projects, stakeholder involvement in projects, advances in computer technology for dashboard designs, metrics, and key performance indicators for project management have become an important focus. This Second Edition of the bestselling book walks readers through everything from the basics of project management metrics and key performance indicators to establishing targets and using dashboards to monitor performance. The content is aligned with PMI's PMBOK Guide and stresses "value" as the main focal point.

  15. The WATCH All-Sky Monitor for the Granat Project

    DEFF Research Database (Denmark)

    Brandt, Søren; Lund, Niels; Rao, A. R.

    1990-01-01

    The Watch X-ray all-sky monitor, which is designed to localize strong X-ray sources and follow their development, is examined, focusing on the addition of four Watch units to the Granat satellite project. The components of the Watch instrument are described and the capabilities and potential...... scientific returns of the Granat project are discussed. The applications of the Watch monitor are given, including the study of time variations of known sources and the detection and localization of new, transient sources....

  16. Project Planning, Implementation and Monitoring Issues, Findings and Recommendations

    Directory of Open Access Journals (Sweden)

    Muhammad Salim Javed

    2012-08-01

    Full Text Available The Higher Education Commission (HEC, Pakistan is one of the prestigious institutions of Government of Pakistan. It sets educational policies for all public and private sector universities of Pakistan. The objective of this study is to find institutional problems and issues of a project planning, implementation and monitoring issues. For this purpose, projects data were collected from Project Directors, HEC personnel's and consultants. Data were collected from 150 public and private sector universities and higher learning institution in the regions of Pakistan (i.e., Khyber Pakhtoon Khwa, Punjab, Sindh, Balochistan and Azad Jamu Kashmir using questionnaires. To provide the data, respondents were given the choice of being interviewed or self-administer the questionnaire and send them back to the researcher. After studying and analyzing the data, main problem and issues in project planning, implementation and monitoring issues were identified. In the view of these responses, rPecommendation had been concluded.

  17. Gb-Sar Interferometry for Structure Monitoring during Infrastructure Projects

    Science.gov (United States)

    Serrano Juan, A.; Vázquez-Suñé, E.; Monserrat, O.; Crosetto, M.; Hoffman, C.; Ledesma, A.; Criollo, R.; Pujades, E.; Velasco, V.; García, A.

    2015-12-01

    Monitoring is a necessary task for infrastructure projects. Ground-based synthetic aperture radar (GB-SAR) has been used in a large variety of displacement measurements. However, it has not yet been applied as a monitoring tool during construction projects. This paper aims to demonstrate that GB-SAR can be very helpful for understanding the mechanisms that control structure deformations and for identifying unexpected events and sensitive areas during construction projects. This could be done in a cost-effective way, which complements the traditional displacement measurements. An experiment was performed in the future railway station of La Sagrera, Barcelona (Spain) to demonstrate the utility of GB-SAR on structure monitoring during construction projects. In this experiment, GB-SAR precisely quantified wall displacements induced by dewatering. Manual data and numerical models have been used to confirm the measurements with a correlation analysis and by comparing measurements and deformation patterns, which have produced similar results. These results validate the use of the GB-SAR technique as a monitoring tool during construction projects.

  18. Project monitor. Final report. [Allegheny County, PA

    Energy Technology Data Exchange (ETDEWEB)

    Hammond, P.Y.; Beck, P.; Doctors, S.I.

    1979-04-27

    Results are reported of a study of consumers' energy attitudes and behavior. Household consumers and small business consumers (both retail and manufacturing) responded to the survey, but only the household results are reported. The study sought to understand energy-related behavior at the level where the various components of energy policy intersect. Attempts are made to attain this goal by determining the extent to which various properties of the individuals and firms are associated with various amounts of conservation. A representative sample of the adult population in Allegheny County, Pennsylvania was interviewed. Part I introduces the measures of household conservation to be used in the survey. Part II analyzes each of the types of energy conservation - general, winterization, heating, cooling, appliance, transportation, and electricity reductions - and relates them to demographic, situation, attitudinal, and perceptual variables in the household sample. Part III deals with the impacts of Project Pacesetter and the United Mine Workers' strike against the coal operators - particularly, the impact of the coal strike on household residents of Allegheny County. Part IV summarizes the findings and uses them for recommendations regarding energy conservation policy. Additional data are presented in 4 appendices. (MCW)

  19. Het Project Monitoring Risicofactoren en Gezondheid Nederland (MORGEN-project). Jaarverslag 1993

    NARCIS (Netherlands)

    Smit HA; Verschuren WMM; Bueno de Mesquita HB; Seidell JC; CCM

    1994-01-01

    The Monitoring Project on Risk Factors for Chronic Diseases (MORGEN-project) is conducted by the National Institute of Public Health and Environmental Protection (RIVM). Its general purpose is to determine the prevalence of risk factors for chronic diseases as well as the prevalence of some specific

  20. 75 FR 8036 - Monitor-Hot Creek Rangeland Project

    Science.gov (United States)

    2010-02-23

    ... comprises approximately 952,234 acres and is located on the Monitor and Hot Creek Mountain Ranges in Eureka, Nye and Lander Counties, Nevada. DATES: Comments concerning the scope of the analysis must be received... Vernon Keller, Project Coordinator, at 1200 Franklin Way, Sparks, Nevada 89431. The telephone number...

  1. Columbia River Channel Improvement Project Rock Removal Blasting: Monitoring Plan

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, Thomas J.; Johnson, Gary E.

    2010-01-29

    This document provides a monitoring plan to evaluate take as outlined in the National Marine Fisheries Service 2002 Biological Opinion for underwater blasting to remove rock from the navigation channel for the Columbia River Channel Improvement Project. The plan was prepared by the Pacific Northwest National Laboratory (PNNL) for the U.S. Army Corps of Engineers (USACE), Portland District.

  2. Het Project Monitoring Risicofactoren en Gezondheid Nederland (MORGEN-project). Jaarverslag 1993

    OpenAIRE

    1994-01-01

    The Monitoring Project on Risk Factors for Chronic Diseases (MORGEN-project) is conducted by the National Institute of Public Health and Environmental Protection (RIVM). Its general purpose is to determine the prevalence of risk factors for chronic diseases as well as the prevalence of some specific chronic conditions in a sample of the general population. In the MORGEN-project, data on the health status and prevalence of risk factors are collected in a random sample of the general population...

  3. Management of the Atmosphere Resource Recovery and Environmental Monitoring Project

    Science.gov (United States)

    Roman, Monsi; Perry, Jay; Howard, David

    2013-01-01

    The Advanced Exploration Systems Program's Atmosphere Resource Recovery and Environmental Monitoring (ARREM) project is working to further optimize atmosphere revitalization and environmental monitoring system architectures. This paper discusses project management strategies that tap into skill sets across multiple engineering disciplines, projects, field centers, and industry to achieve the project success. It is the project's objective to contribute to system advances that will enable sustained exploration missions beyond Lower Earth Orbit (LEO) and improve affordability by focusing on the primary goals of achieving high reliability, improving efficiency, and reducing dependence on ground-based logistics resupply. Technology demonstrations are achieved by infusing new technologies and concepts with existing developmental hardware and operating in a controlled environment simulating various crewed habitat scenarios. The ARREM project's strengths include access to a vast array of existing developmental hardware that perform all the vital atmosphere revitalization functions, exceptional test facilities to fully evaluate system performance, and a well-coordinated partnering effort among the NASA field centers and industry partners to provide the innovative expertise necessary to succeed.

  4. Water-Level Monitoring Plan for the Hanford Groundwater Monitoring Project

    Energy Technology Data Exchange (ETDEWEB)

    D.R. Newcomer; J.P. McDonald; M.A. Chamness

    1999-09-30

    This document presents the water-level monitoring plan for the Hanford Groundwater Monitoring Project, conducted by the Pacific Northwest National Laboratory (PNNL). Water-level monitoring of the groundwater system beneath the Hanford Site is performed to fulfill the requirements of various state and federal regulations, orders, and agreements. The primary objective of this monitoring is to determine groundwater flow rates and directions. To meet this and other objectives, water-levels are measured annually in monitoring wells completed within the unconfined aquifer system, the upper basalt-confined aquifer system, and in the lower basalt-confined aquifers for surveillance monitoring. At regulated waste units, water levels are taken monthly, quarterly, semi-annually, or annually, depending on the hydrogeologic conditions and regulatory status of a given site. The techniques used to collect water-level data are described in this document along with the factors that affect the quality of the data and the strategies employed by the project to minimize error in the measurement and interpretation of water levels. Well networks are presented for monitoring the unconfined aquifer system, the upper basalt-confined aquifer system, and the lower basalt-confined aquifers, all at a regional scale (surveillance monitoring), as well as the local-scale well networks for each of the regulated waste units studied by this project (regulated-unit monitoring). The criteria used to select wells for water-table monitoring are discussed. It is observed that poor well coverage for surveillance water-table monitoring exists south and west of the 200-West Area, south of the 100-F Area, and east of B Pond and the Treated Effluent Disposal Facility (TEDF). This poor coverage results from a lack of wells suitable for water-table monitoring, and causes uncertainty in representation of the regional water-table in these areas. These deficiencies are regional in scale and apply to regions outside

  5. A Web-Based Monitoring System for Multidisciplinary Design Projects

    Science.gov (United States)

    Rogers, James L.; Salas, Andrea O.; Weston, Robert P.

    1998-01-01

    In today's competitive environment, both industry and government agencies are under pressure to reduce the time and cost of multidisciplinary design projects. New tools have been introduced to assist in this process by facilitating the integration of and communication among diverse disciplinary codes. One such tool, a framework for multidisciplinary computational environments, is defined as a hardware and software architecture that enables integration, execution, and communication among diverse disciplinary processes. An examination of current frameworks reveals weaknesses in various areas, such as sequencing, displaying, monitoring, and controlling the design process. The objective of this research is to explore how Web technology, integrated with an existing framework, can improve these areas of weakness. This paper describes a Web-based system that optimizes and controls the execution sequence of design processes; and monitors the project status and results. The three-stage evolution of the system with increasingly complex problems demonstrates the feasibility of this approach.

  6. PENERAPAN SISTEM ERP DALAM MEMBUAT PROJECT FEASIBILITY, PROJECT STATUS DAN PROJECT MONITORING PADA PERUSAHAAN DI BIDANG KONTRAKTOR

    Directory of Open Access Journals (Sweden)

    Hendra Alianto

    2013-11-01

    cost reduction, and improvement of business processes, which will result in an increase in the work (productivity to become more efficient and effective. However, practically some organizations have problems on running ERP system, some even fail. Therefore, a strategy is needed to help the information systems project. Making project feasibility, project status and project monitoring ERP system can be used as a guide in the design of the ERP program applications to become more user-friendly and suitable for the organization needs. The ERP system applied to a contracting company will increase productivity and achieve the level of effectiveness and efficiency of the company's operations. Through strategies in making project feasibility, and status monitoring with ERP system will provide a positive contribution to the development and objectives of the company, so as to improve the effectiveness and efficiency in the processing operations.

  7. Project W-420 Ventilation Stack Monitoring System Year 2000 Compliance Assessment Project Plan

    Energy Technology Data Exchange (ETDEWEB)

    BUSSELL, J.H.

    1999-08-25

    This assessment describes the potential Year 2000 (Y2K) problems and describes the methods for achieving Y2K Compliance for Project W-420, Ventilation Stack Monitoring Systems Upgrades. The purpose of this assessment is to give an overview of the project. This document will not be updated and any dates contained in this document are estimates and may change. The project work scope includes upgrades to ventilation stacks and generic effluent monitoring systems (GEMS) at the 244-A Double Contained Receiver Tank (DCRT), the 244-BX DCRT, the 244-CR Vault, tanks 241-C-105 and 241-C-106, the 244-S DCRT, and the 244-TX DCRT. A detailed description of system dates, functions, interfaces, potential Y2K problems, and date resolutions can not be described since the project is in the definitive design phase, This assessment will describe the methods, protocols, and practices to ensure that equipment and systems do not have Y2K problems.

  8. Biomedical Monitoring By A Novel Noncontact Radio Frequency Technology Project

    Science.gov (United States)

    Oliva-Buisson, Yvette J. (Compiler)

    2014-01-01

    The area of Space Health and Medicine is one of the NASA's Space Technology Grand Challenges. Space is an extreme environment which is not conducive to human life. The extraterrestrial environment can result in the deconditioning of various human physiological systems and thus require easy to use physiological monitoring technologies in order to better monitor space crews for appropriate health management and successful space missions and space operations. Furthermore, the Space Technology Roadmap's Technology Area Breakdown Structure calls for improvements in research to support human health and performance (Technology Area 06). To address these needs, this project investigated a potential noncontact and noninvasive radio frequency-based technique of monitoring central hemodynamic function in human research subjects in response to orthostatic stress.

  9. Matrix metalloproteinase-12 (MMP-12) in osteoclasts

    DEFF Research Database (Denmark)

    Hou, Peng; Troen, Tine; Ovejero, Maria C

    2004-01-01

    Osteoclasts require matrix metalloproteinase (MMP) activity and cathepsin K to resorb bone, but the critical MMP has not been identified. Osteoclasts express MMP-9 and MMP-14, which do not appear limiting for resorption, and the expression of additional MMPs is not clear. MMP-12, also called...

  10. Keefektifan Model Pembelajaran Generatif dan MMP Terhadap Kemampuan Pemecahan Masalah

    Directory of Open Access Journals (Sweden)

    F. Muttaqid Alba

    2013-12-01

    Full Text Available AbstrakPenelitian ini bertujuan untuk mengetahui keefektifan pembelajaran menggunakan model ge-neratif dan model Missouri Mathematics Project (MMPterhadap kemampuan pemacahan masalah siswa kelas X materi jarak pada bangun ruang dan untuk mengetahui pembelajaran yang lebih efektif antara pembelajaran dengan model pembelajaran generatif dan pembela-jaran dengan model pembelajaran MMP terhadap kemampuan pemecahan masalah. Populasi dalam penelitian ini adalah siswa kelas X MAN 1 Kota Magelang tahun pelajaran 2012/2013 yang berada dalam sepuluh kelas. Uji ketuntasan belajar memberikan hasil yaitu sis-wa kelas eksperimen 1 dan 2 telah mencapai ketuntasan belajar. Uji proporsi memberikan ha-sil yakni kemampuan pemecahan masalah siswa kelas eksperimen 1 sama baiknya dibanding kemampuan pemecahan masalah siswa kelas eksperimen 2. Hasil Penelitian menunjukkan pembelajaran model generatif dan MMP efektif terhadap kemampuan pemecahan masalah pada materi jarak pada bangun ruang dan pembelajaran menggunakan model pembelajaran generatif sama efektifnya dengan pembelajaran menggunakan model pembelajaran MMP terhadap kemampuan pemecahan masalah. Kata Kunci: Generatif; Jarak pada Bangun Ruang; Kemampuan Pemecahan Masalah; MMP.  AbstractThe purpose of this study was to know whether learning with generative model and Missouri Mathematics Project (MMP model effective against problem solving ability of grade X students of distance in solid shapes material and to know which one was better between generative learning model and MMP model. The population of this study was the students of grade X MA State 1 Magelang year 2012/2013 in 10 classes. From the result of the test was obtained that experiment class students achieved the learning completeness. From the proportion test results gotten the student problem solving ability of 1st experiment class was more same as than 2nd experiment class. The research result showed that the generative and MMP model effective

  11. The MAGNUM (Multicolor Active Galactic NUclei Monitoring) Project

    Science.gov (United States)

    Yoshii, Y.; Kobayashi, Y.; Minezaki, T.

    2003-05-01

    The MAGNUM Project is designed to carry out long-term monitoring observations of hundreds of active galactic nuclei in the visible and near-infrared wavelength regions. In order to obtain these observations, we built a new 2m optical-infrared telescope, and located it near the Haleakala summit at a height of 3050m within the area of the University of Hawaii's Haleakala Observatory on the Hawaiian Island of Maui. The Project was funded in 1995 and preliminary observations were started early in 2001. We are working toward the realization of an unmanned, automated observatory which is suitable to relatively simple and stable observations over many years. We present an overview of the Project and its current status.

  12. Integrated monitoring and surveillance system demonstration project: Phase I accomplishments

    Energy Technology Data Exchange (ETDEWEB)

    Aumeier, S.E.; Walters, B.G.; Crawford, D.C. [and others

    1997-01-15

    The authors present the results of the Integrated Monitoring and Surveillance System (IMSS) demonstration project Phase I efforts. The rationale behind IMSS development is reviewed and progress in each of the 5 basic tasks is detailed. Significant results include decisions to use Echelon LonWorks networking protocol and Microsoft Access for the data system needs, a preliminary design for the plutonium canning system glovebox, identification of facilities and materials available for the demonstration, determination of possibly affected facility documentation, and a preliminary list of available sensor technologies. Recently imposed changes in the overall project schedule and scope are also discussed and budgetary requirements for competition of Phase II presented. The results show that the IMSS demonstration project team has met and in many cases exceeded the commitments made for Phase I deliverables.

  13. Detection of MMP-2 and MMP-9 in the Lesions of Psoriasis%银屑病皮损中MMP-2 MMP-9的检测

    Institute of Scientific and Technical Information of China (English)

    陈晋广; 任小丽; 胡雅玉; 陈祥恩

    2005-01-01

    目的探讨MMP-2,MMP-9在细胞外基质(ECM)降解和银屑病发病机理中的作用及意义.方法采用免疫组化ABC法检测银屑病患者皮损中MMP-2,MMP-9.结果银屑病皮损中既可检测到MMP-2,又可检测到MMP-9,而在正常皮肤则为阴性.结论MMP-2,MMP-9参与了银屑病的发病过程.

  14. TPS In-Flight Health Monitoring Project Progress Report

    Science.gov (United States)

    Kostyk, Chris; Richards, Lance; Hudston, Larry; Prosser, William

    2007-01-01

    Progress in the development of new thermal protection systems (TPS) is reported. New approaches use embedded lightweight, sensitive, fiber optic strain and temperature sensors within the TPS. Goals of the program are to develop and demonstrate a prototype TPS health monitoring system, develop a thermal-based damage detection algorithm, characterize limits of sensor/system performance, and develop ea methodology transferable to new designs of TPS health monitoring systems. Tasks completed during the project helped establish confidence in understanding of both test setup and the model and validated system/sensor performance in a simple TPS structure. Other progress included complete initial system testing, commencement of the algorithm development effort, generation of a damaged thermal response characteristics database, initial development of a test plan for integration testing of proven FBG sensors in simple TPS structure, and development of partnerships to apply the technology.

  15. International Remote Monitoring Project Embalse Nuclear Power Station, Argentina Embalse Remote Monitoring System

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Sigfried L.; Glidewell, Donnie D.; Bonino, Anibal; Bosler, Gene; Mercer, David; Maxey, Curt; Vones, Jaromir; Martelle, Guy; Busse, James; Kadner, Steve; White, Mike; Rovere, Luis

    1999-07-21

    The Autoridad Regulatoria Nuclear of Argentina (ARN), the International Atomic Energy Agency (IAEA), ABACC, the US Department of Energy, and the US Support Program POTAS, cooperated in the development of a Remote Monitoring System for nuclear nonproliferation efforts. This system was installed at the Embalse Nuclear Power Station last year to evaluate the feasibility of using radiation sensors in monitoring the transfer of spent fuel from the spent fuel pond to dry storage. The key element in this process is to maintain continuity of knowledge throughout the entire transfer process. This project evaluated the fundamental design and implementation of the Remote Monitoring System in its application to regional and international safeguard efficiency. New technology has been developed to enhance the design of the system to include storage capability on board sensor platforms. This evaluation has led to design enhancements that will assure that no data loss will occur during loss of RF transmission of the sensors.

  16. Plan for Demonstration of Online Monitoring for the Light Water Reactor Sustainability Online Monitoring Project

    Energy Technology Data Exchange (ETDEWEB)

    Magdy S. Tawfik; Vivek Agarwal; Nancy J. Lybeck

    2011-09-01

    Condition based online monitoring technologies and development of diagnostic and prognostic methodologies have drawn tremendous interest in the nuclear industry. It has become important to identify and resolve problems with structures, systems, and components (SSCs) to ensure plant safety, efficiency, and immunity to accidents in the aging fleet of reactors. The Machine Condition Monitoring (MCM) test bed at INL will be used to demonstrate the effectiveness to advancement in online monitoring, sensors, diagnostic and prognostic technologies on a pilot-scale plant that mimics the hydraulics of a nuclear plant. As part of this research project, INL will research available prognostics architectures and their suitability for deployment in a nuclear power plant. In addition, INL will provide recommendation to improve the existing diagnostic and prognostic architectures based on the experimental analysis performed on the MCM test bed.

  17. Monitoring Global Croplands with Coarse Resolution Earth Observations: The Global Agriculture Monitoring (GLAM Project

    Directory of Open Access Journals (Sweden)

    Inbal Becker-Reshef

    2010-06-01

    Full Text Available In recent years there has been a dramatic increase in the demand for timely, comprehensive global agricultural intelligence. Timely information on global crop production is indispensable for combating the growing stress on the world’s crop production and for securing both short-term and long-term stable and reliable supply of food. Global agriculture monitoring systems are critical to providing this kind of intelligence and global earth observations are an essential component of an effective global agricultural monitoring system as they offer timely, objective, global information on croplands distribution, crop development and conditions as the growing season progresses. The Global Agriculture Monitoring Project (GLAM, a joint NASA, USDA, UMD and SDSU initiative, has built a global agricultural monitoring system that provides the USDA Foreign Agricultural Service (FAS with timely, easily accessible, scientifically-validated remotely-sensed data and derived products as well as data analysis tools, for crop-condition monitoring and production assessment. This system is an integral component of the USDA’s FAS Decision Support System (DSS for agriculture. It has significantly improved the FAS crop analysts’ ability to monitor crop conditions, and to quantitatively forecast crop yields through the provision of timely, high-quality global earth observations data in a format customized for FAS alongside a suite of data analysis tools. FAS crop analysts use these satellite data in a ‘convergence of evidence’ approach with meteorological data, field reports, crop models, attaché reports and local reports. The USDA FAS is currently the only operational provider of timely, objective crop production forecasts at the global scale. These forecasts are routinely used by the other US Federal government agencies as well as by commodity trading companies, farmers, relief agencies and foreign governments. This paper discusses the operational components

  18. Expression and significance of MMP-2,MMP-3 and MMP-9 in the gastric carcinoma%MMP-2、MMP-3和 MMP-9在胃癌患者中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    杨云鹏; 刘莉; 李慧

    2016-01-01

    目的:研究 MMP-2、MMP-3和 MMP-9在胃癌细胞转移中作用,进一步探讨 MMP-2、MMP-3和 MMP-9的临床意义。方法体外培养 SGC-7901胃癌细胞和 GES-1胃上皮细胞,划痕损伤实验模型和 Transwell 小室模型法检测这2种细胞的迁移, ELISA 法检测培养液中 MMP-2、MMP-3和 MMP-9的含量。免疫组化检测胃癌、胃炎患者和正常人 MMP-3的阳性率,ELISA 检测血清中 MMP-2、MMP-3和 MMP-9的含量。结果细胞划痕实验和 Transwell 实验均显示,SGC-7901细胞迁移能力强于 GES-1;SGC-7901分泌的3种蛋白含量均高于 GES-1;免疫组化结果显示,胃癌患者 MMP-3的阳性率84.4%,高于胃炎患者和正常人。其血清中 MMP-2、MMP-3和 MMP-9也明显高于胃炎患者和正常人。结论胃癌细胞的转移能力与 MMP-2、MMP-3和 MMP-9的含量相关,3种蛋白可用于胃癌的早期诊断。%Objecitive The research was in order to explore the roles of MMP-2,MMP-3 and MMP 9 which played in the gastric cancer cell metastasis,and make a further study of the clinical signifance.Methods Both SGC-7901 and GES-1 were cultured in vivo.The migra-tion were examined by Wound-healing and the Transwell assay.The expression of MMP-2,MMP-3 and MMP 9 in the medium were detected by ELISA.The positive rate of MMP-3 in the gastric cancer,gastritis and normal was used the IHC,and the serum of MMP-2,MMP-3 and MMP-9 were also examined by ELISA.Results Both Wound-healing and Transwell assay showed that the migration of SGC-7901 cells was more quicker than the GES-1.Comparing to GES-1,the MMP-2,MMP-3 and MMP-9 were higher in the SGC-7901.The immunohistochemical results showed that the positive rate of MMP-3 in the gastric cancer patients was 84.4%,it was higher than the latter.The serum levels of MMP-2 MMP-3 and MMP-9 were also significantly higher than others.Conclusion The migration of gastric cancer cells was depended on the MMP-2,MMP-3 and MMP-9.The 3 proteins can be used

  19. An overview of the Environmental Monitoring Computer Automation Project

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, S.M.; Lorenz, R.

    1992-01-01

    The Savannah River Site (SRS) was bulk to produce plutonium and tritium for national defense. As a result of site operations, routine and accidental releases of radionuclides have occurred. The effects these releases have on the k>cal population and environment are of concern to the Department of Energy (DOE) and SRS personnel. Each year, approximately 40,000 environmental samples are collected. The quality of the samples, analytical methods and results obtained are important to site personnel. The Environmental Monitoring Computer Automation Project (EMCAP) was developed to better manage scheduling, log-in, tracking, analytical results, and report generation. EMCAP can be viewed as a custom Laboratory Information Management System (LIMS) with the ability to schedule samples, generate reports, and query data. The purpose of this paper is to give an overview of the SRS environmental monitoring program, describe the development of EMCAP software and hardware, discuss the different software modules, show how EMCAP improved the Environmental Monitoring Section program, and examine the future of EMCAP at SRS.

  20. An overview of the Environmental Monitoring Computer Automation Project

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, S.M.; Lorenz, R.

    1992-12-31

    The Savannah River Site (SRS) was bulk to produce plutonium and tritium for national defense. As a result of site operations, routine and accidental releases of radionuclides have occurred. The effects these releases have on the k>cal population and environment are of concern to the Department of Energy (DOE) and SRS personnel. Each year, approximately 40,000 environmental samples are collected. The quality of the samples, analytical methods and results obtained are important to site personnel. The Environmental Monitoring Computer Automation Project (EMCAP) was developed to better manage scheduling, log-in, tracking, analytical results, and report generation. EMCAP can be viewed as a custom Laboratory Information Management System (LIMS) with the ability to schedule samples, generate reports, and query data. The purpose of this paper is to give an overview of the SRS environmental monitoring program, describe the development of EMCAP software and hardware, discuss the different software modules, show how EMCAP improved the Environmental Monitoring Section program, and examine the future of EMCAP at SRS.

  1. Standards for documenting and monitoring bird reintroduction projects

    Science.gov (United States)

    Sutherland, W.J.; Armstrong, D.; Butchart, S.H.M.; Earnhardt, J.M.; Ewen, J.; Jamieson, I.; Jones, C.G.; Lee, R.; Newbery, P.; Nichols, J.D.; Parker, K.A.; Sarrazin, F.; Seddon, P.J.; Shah, N.; Tatayah, V.

    2010-01-01

    It would be much easier to assess the effectiveness of different reintroduction methods, and so improve the success of reintroductions, if there was greater standardization in documentation of the methods and outcomes. We suggest a series of standards for documenting and monitoring the methods and outcomes associated with reintroduction projects for birds. Key suggestions are: documenting the planned release before it occurs, specifying the information required on each release, postrelease monitoring occurring at standard intervals of 1 and 5 years (and 10 for long-lived species), carrying out a population estimate unless impractical, distinguishing restocked and existing individuals when supplementing populations, and documenting the results. We suggest these principles would apply, largely unchanged, to other vertebrate classes. Similar methods could be adopted for invertebrates and plants with appropriate modification. We suggest that organizations publically state whether they will adopt these approaches when undertaking reintroductions. Similar standardization would be beneficial for a wide range of topics in environmental monitoring, ecological studies, and practical conservation. ??2010 Wiley Periodicals, Inc.

  2. Tumour-targeting properties of antibodies specific to MMP-1A, MMP-2 and MMP-3

    Energy Technology Data Exchange (ETDEWEB)

    Pfaffen, Stefanie; Frey, Katharina; Stutz, Irene; Roesli, Christoph; Neri, Dario [Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zuerich, Zuerich (Switzerland)

    2010-08-15

    Matrix metalloproteinases (MMPs), a group of more than 20 zinc-containing endopeptidases, are upregulated in many diseases, but several attempts to use radiolabelled MMP inhibitors for imaging tumours have proved unsuccessful in mouse models, possibly due to the limited specificity of these agents or their unfavourable pharmacokinetic profiles. In principle, radiolabelled monoclonal antibodies could be considered for the selective targeting and imaging of individual MMPs. We cloned, produced and characterized high-affinity monoclonal antibodies specific to murine MMP-1A, MMP-2 and MMP-3 in SIP (small immunoprotein) miniantibody format using biochemical and immunochemical methods. We also performed comparative biodistribution analysis of their tumour-targeting properties at three time points (3 h, 24 h, 48 h) in mice bearing subcutaneous F9 tumours using radioiodinated protein preparations. The clinical stage L19 antibody, specific to the alternatively spliced EDB domain of fibronectin, was used as reference tumour-targeting agent for in vivo studies. All anti-MMP antibodies and SIP(L19) strongly stained sections of F9 tumours when assessed by immunofluorescence methods. In biodistribution experiments, SIP(SP3), specific to MMP-3, selectively accumulated at the tumour site 24 and 48 h after intravenous injection, but was rapidly cleared from other organs. By contrast, SIP(SP1) and SIP(SP2), specific to MMP-1A and MMP-2, showed no preferential accumulation at the tumour site. Antibodies specific to MMP-3 may serve as vehicles for the efficient and selective delivery of imaging agents or therapeutic molecules to sites of disease. (orig.)

  3. STRATEGY AND PLANNING - PROJECT FOR MONITORING STRICTO SENSU POSTGRADUATE ALUMNI

    Directory of Open Access Journals (Sweden)

    Emerson Antonio Maccari

    2014-07-01

    Full Text Available The Coordination of Improvement of Higher Education Personnel (CAPES has been contributing to the development of post-graduate studies in Brazil, through its system of evaluation. Lately, CAPES signaled the importance of follow the professional performance of the alumni as a way to measure the quality of courses. One difficulty reported by institutions that intend to recognize the trajectory of its graduates is to compile a lot of isolated and outdated data. In order to structure the data collection and to assist educational managers in decision making, we propose the development of a system that enables the evolution of the students and alumni professional career, in order to diagnose the influence of the courses. Based on literature review, this study presents an analysis and makes recommendations about the Monitoring Alumni Project planning. As a result, it is expected that the analysis will serve as a driver for conducting the project, aiming to contribute to the academic reflections, and in practice, contribute to improve educational projects quality.

  4. Immunohistochemical expression of MMP-14 and MMP-2, and MMP-2 activity during human ovarian follicular development

    OpenAIRE

    2014-01-01

    BACKGROUND: The aim of this study was to investigate the presence of MMP-14 and MMP-2 during human ovarian follicular development using immunohistochemistry, and the activity of MMP-2 in follicular fluid using zymography. METHODS: Ovarian tissue collected from the archives of the Department of Pathology was examined and medical records and histopathology were reviewed. Follicular fluids were collected at the IVF-department and analyzed using zymography. RESULTS: MMP-14 and MMP-2 were increasi...

  5. Circulating levels of matrix metalloproteinase-9 (MMP-9, neutrophil gelatinase-associated lipocalin (NGAL and their complex MMP-9/NGAL in breast cancer disease

    Directory of Open Access Journals (Sweden)

    Nonni Afroditi

    2009-11-01

    Full Text Available Abstract Background Recent evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL expression is induced in many types of human cancer, while detection of its complex with matrix metalloproteinase-9 (MMP-9 is correlated with cancer disease status. We aim to evaluate the serum expression of MMP-9, NGAL and their complex (MMP-9/NGAL during the diagnostic work-up of women with breast abnormalities and investigate their correlation with disease severity. Methods The study included 113 women with non-palpable breast lesions undergoing vacuum-assisted breast biopsy for histological diagnosis, and 30 healthy women, which served as controls. Expression levels of MMP-9, NGAL and their complex MMP-9/NGAL were determined in peripheral blood samples with immunoenzymatic assays. Results Women with invasive ductal carcinoma exhibited significantly increased levels of MMP-9, NGAL and MMP-9/NGAL compared to healthy controls (MMP-9: p Conclusion These findings suggest that the serum measurement of MMP-9 and NGAL may be useful in non-invasively monitoring breast cancer progression, while supporting their potential role as early biomarkers of breast disease status.

  6. 7 CFR 634.50 - Program and project monitoring and evaluation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Program and project monitoring and evaluation. 634.50... Evaluation § 634.50 Program and project monitoring and evaluation. (a) Comprehensive USDA/EPA joint water... and for general RCWP program management. (2) Monitoring, evaluation, and analysis is a joint...

  7. Matrix metalloproteinase-12 (MMP-12) in osteoclasts

    DEFF Research Database (Denmark)

    Hou, Peng; Troen, Tine; Ovejero, Maria C

    2004-01-01

    and resorption. Furthermore, we investigated the role of MMP-12 in bone resorption and osteoclast recruitment by comparing MMP-12 knockout and wild-type mice in specialized culture models known to depend on MMP activity, as well as in the ovariectomy model, and we did not find any indication for a limiting role......Osteoclasts require matrix metalloproteinase (MMP) activity and cathepsin K to resorb bone, but the critical MMP has not been identified. Osteoclasts express MMP-9 and MMP-14, which do not appear limiting for resorption, and the expression of additional MMPs is not clear. MMP-12, also called....... Northern blots show that highly purified rabbit osteoclasts in culture express MMP-12 at the same level as macrophages, whereas in situ hybridizations performed on rabbit bone do not show any MMP-12 expression in osteoclasts whatever the bone type. In contrast, in situ hybridizations performed on mouse...

  8. Environmental Monitoring - Lillgrund Offshore Wind Farm. Lillgrund Pilot Project

    Energy Technology Data Exchange (ETDEWEB)

    Davy, Thomas (Vattenfall Vindkraft AB, Stockholm (Sweden))

    2009-02-15

    The purpose of this report is to describe the environmental monitoring measures performed for the Lillgrund Offshore Wind Farm and to summarize the results and conclusions. Construction work started in 2006 and the plant was energized in December 2007. At the time of construction Lillgrund was the third largest wind farm offshore in the world and the first large offshore wind farm in Sweden. The purpose of the environmental monitoring is to ensure that there are no negative impacts on the environment stemming from construction of the Lillgrund wind farm as well as to ensure that the conditions stated by the authorities and the Company's commitments are met. The aim is also to collect more information and knowledge on the possible environmental impact for future offshore wind farm projects. For the Lillgrund project, all monitoring programs were included in one document, Monitoring Program - Lillgrund. It was included as part of the procedures to ensure that the Swedish legal requirements on operators control were followed. The authorities approved the document before construction started. The monitoring measures performed during the construction phase included: - A feedback and monitoring program on dredging and spillage; - A feedback and monitoring program on flora and fauna; - Studies and inspections of the refilling and re-establishment of the sea bottom; - Procedure for operators control. The mean measured sediment spillage, as part of the monitoring program on dredging and spillage, varied between 4.6 - 4.8% depending on dredger used. The maximum value allowed by the conditions is 5%. In general, the calculated values for suspended material were limited and the critical value of 0.01 kg/m3 was exceeded only in minor areas for a very limited time. No corrective actions were required. The deposition of sediment was very low and even at the most effected sites it was only just over 1 mm. The largest dredging volumes were for the foundation work, in total 82

  9. The Monitor project: Searching for occultations in young open clusters

    CERN Document Server

    Aigrain, S; Irwin, J; Hebb, L; Irwin, M; Favata, F; Moraux, E; Pont, F; Aigrain, Suzanne; Hodgkin, Simon; Irwin, Jonathan; Hebb, Leslie; Irwin, Mike; Favata, Fabio; Moraux, Estelle; Pont, Frederic

    2006-01-01

    The Monitor project is a photometric monitoring survey of nine young (1-200Myr) clusters in the solar neighbourhood to search for eclipses by very low mass stars and brown dwarfs and for planetary transits in the light curves of cluster members. It began in the autumn of 2004 and uses several 2 to 4m telescopes worldwide. We aim to calibrate the relation between age, mass, radius and where possible luminosity, from the K-dwarf to the planet regime, in an age range where constraints on evolutionary models are currently very scarce. Any detection of an exoplanet in one of our youngest targets (<=10Myr) would also provide important constraints on planet formation and migration timescales and their relation to proto-planetary disc lifetimes. Finally, we will use the light curves of cluster members to study rotation and flaring in low-mass pre-main sequence stars. The present paper details the motivation, science goals and observing strategy of the survey. We present a method to estimate the sensitivity and num...

  10. Environmental Monitoring - Lillgrund Offshore Wind Farm. Lillgrund Pilot Project

    Energy Technology Data Exchange (ETDEWEB)

    Davy, Thomas (Vattenfall Vindkraft AB, Stockholm (Sweden))

    2009-02-15

    The purpose of this report is to describe the environmental monitoring measures performed for the Lillgrund Offshore Wind Farm and to summarize the results and conclusions. Construction work started in 2006 and the plant was energized in December 2007. At the time of construction Lillgrund was the third largest wind farm offshore in the world and the first large offshore wind farm in Sweden. The purpose of the environmental monitoring is to ensure that there are no negative impacts on the environment stemming from construction of the Lillgrund wind farm as well as to ensure that the conditions stated by the authorities and the Company's commitments are met. The aim is also to collect more information and knowledge on the possible environmental impact for future offshore wind farm projects. For the Lillgrund project, all monitoring programs were included in one document, Monitoring Program - Lillgrund. It was included as part of the procedures to ensure that the Swedish legal requirements on operators control were followed. The authorities approved the document before construction started. The monitoring measures performed during the construction phase included: - A feedback and monitoring program on dredging and spillage; - A feedback and monitoring program on flora and fauna; - Studies and inspections of the refilling and re-establishment of the sea bottom; - Procedure for operators control. The mean measured sediment spillage, as part of the monitoring program on dredging and spillage, varied between 4.6 - 4.8% depending on dredger used. The maximum value allowed by the conditions is 5%. In general, the calculated values for suspended material were limited and the critical value of 0.01 kg/m3 was exceeded only in minor areas for a very limited time. No corrective actions were required. The deposition of sediment was very low and even at the most effected sites it was only just over 1 mm. The largest dredging volumes were for the foundation work, in total 82

  11. Stereo Vision for SPHERES-based Navigation and Monitoring Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Maintenance operations and scientific research on the International Space Station (ISS) require active monitoring. Currently the majority of monitoring and recording...

  12. Biodiversity monitoring in Europe: the EU FP7 EBONE project. European biodiversity observation NEtwork

    CSIR Research Space (South Africa)

    Lück-Vogel, Melanie

    2008-09-01

    Full Text Available submission Presentation Poster presentation A) Title Biodiversity Monitoring in Europe: The EU FP7 EBONE project European Biodiversity Observation NEtwork B) Short title EBONE - European Biodiversity Observation NEtwork C) Author(s) Vogel, M. (1..., South Africa F) Biodiversity Monitoring in Europe: The EU FP7 EBONE project European Biodiversity Observation NEtwork On April 1st, 2008 the EU FP7 project EBONE (http://www.ebone.wur.nl/) was launched. The aim of the project...

  13. National inventory of selected biological monitoring programs. Summary report of current or recently completed projects, 1976

    Energy Technology Data Exchange (ETDEWEB)

    Kemp, H. T.

    1976-10-01

    The Inventory has resulted in establishment of a series of data bases containing biological monitoring information of varying types, namely, directory of investigators, record of projects received from mail questionnaire, detailed description of selected biomonitoring projects, and bibliographic citations supporting the projects received. This report contains detailed descriptions of selected biomonitoring projects organized on a state-by-state basis and with appropriate indices.

  14. Plasma MMP1 and MMP8 expression in breast cancer: Protective role of MMP8 against lymph node metastasis

    Directory of Open Access Journals (Sweden)

    Christiaens Marie-Rose

    2008-03-01

    Full Text Available Abstract Background Elevated levels of matrix metalloproteinases have been found to associate with poor prognosis in various carcinomas. This study aimed at evaluating plasma levels of MMP1, MMP8 and MMP13 as diagnostic and prognostic markers of breast cancer. Methods A total of 208 breast cancer patients, of which 21 with inflammatory breast cancer, and 42 healthy controls were included. Plasma MMP1, MMP8 and MMP13 levels were measured using ELISA and correlated with clinicopathological characteristics. Results Median plasma MMP1 levels were higher in controls than in breast cancer patients (3.45 vs. 2.01 ng/ml, while no difference was found for MMP8 (10.74 vs. 10.49 ng/ml. ROC analysis for MMP1 revealed an AUC of 0.67, sensitivity of 80% and specificity of 24% at a cut-off value of 4.24 ng/ml. Plasma MMP13 expression could not be detected. No correlation was found between MMP1 and MMP8 levels. We found a trend of lower MMP1 levels with increasing tumour size (p = 0.07; and higher MMP8 levels with premenopausal status (p = 0.06 and NPI (p = 0.04. The median plasma MMP1 (p = 0.02 and MMP8 (p = 0.007 levels in the non-inflammatory breast cancer patients were almost twice as high as those found in the inflammatory breast cancer patients. Intriguingly, plasma MMP8 levels were positively associated with lymph node involvement but showed a negative correlation with the risk of distant metastasis. Both controls and lymph node negative patients (pN0 had lower MMP8 levels than patients with moderate lymph node involvement (pN1, pN2 (p = 0.001; and showed a trend for higher MMP8 levels compared to patients with extensive lymph node involvement (pN3 and a strong predisposition to distant metastasis (p = 0.11. Based on the hypothesis that blood and tissue protein levels are in reverse association, these results suggest that MMP8 in the tumour may have a protective effect against lymph node metastasis. Conclusion In summary, we observed differences in MMP1

  15. Genetic Association of MMP10, MMP14, and MMP16 with Dental Caries

    Science.gov (United States)

    Feingold, E.; Cooper, M.; Vanyukov, M. M.; Maher, B. S.; Slayton, R. L.; Willing, M. C.; Reis, S. E.; Crout, R. J.; Weyant, R. J.; Levy, S. M.; Marazita, M. L.

    2017-01-01

    Matrix metalloproteinases (MMPs), which degrade extracellular proteins as part of a variety of physiological processes, and their inhibitors have been implicated in the dental caries process. Here we investigated 28 genetic variants spanning the MMP10, MMP14, and MMP16 genes to detect association with dental caries experience in 13 age- and race-stratified (n = 3,587) samples from 6 parent studies. Analyses were performed separately for each sample, and results were combined across samples by meta-analysis. Two SNPs (rs2046315 and rs10429371) upstream of MMP16 were significantly associated with caries in an individual sample of white adults and via meta-analysis across 8 adult samples after gene-wise adjustment for multiple comparisons. Noteworthy is SNP rs2046315 (p = 8.14 × 10−8) association with caries in white adults. This SNP was originally nominated in a genome-wide-association study (GWAS) of dental caries in a sample of white adults and yielded associations in a subsequent GWAS of surface level caries in white adults as well. Therefore, in our study, we were able to recapture the association between rs2046315 and dental caries in white adults. Although we did not strengthen evidence that MMPs 10, 14, and 16 influence caries risk, MMP16 is still a likely candidate gene to pursue. PMID:28348596

  16. Community air monitoring and the Village Green Project ...

    Science.gov (United States)

    Cost and logistics are practical issues that have historically constrained the number of locations where long-term, active air pollution measurement is possible. In addition, traditional air monitoring approaches are generally conducted by technical experts with limited engagement with community members. EPA’s Village Green Project (VGP) is a prototype technology designed to add value to a community environment – VGP is a park bench equipped with air and meteorological instruments that measure ozone, fine particles, wind, temperature, and humidity at a one-minute time resolution, with the open-source Arduino microprocessor operating as the system controller. The data are streamed wirelessly to a database, passed through automatic diagnostic quality checks, and then made publically available on an engaging website. The station was designed to minimize power use; it consumes an estimated 15W and operates entirely on solar power, is engineered to run for several days with minimal solar radiation, and is capable of automatically shutting down components of the system to conserve power and restarting when power availability increases. Situated outside a public library in Durham, North Carolina, VGP has also been a gathering location for air quality experts to engage with community members. During the time span of June, 2013 through January, 2014, the station collected about 3500 hours of ozone and PM2.5 data, with over 90% up-time operating only on solar po

  17. Monitoring and calibration of the ALICE time projection chamber

    CERN Document Server

    Larsen, Dag Toppe

    The aim of the A Large Ion Collider Experiment (ALICE) experiment at CERN is to study the properties of the Quark–Gluon Plasma (QGP). With energies up to 5.5 A T eV for Pb+Pb collisions, the Large Hadron Collider (LHC) sets a new benchmark for heavy- ion collisions, and opens the door to a so far unexplored energy domain. A closer look at some of the physics topics of ALICE is given in Chapter 1. ALICE consists of several sub-detectors and other sub-systems. The various sub- detectors are designed for exploring different aspects of the particle production of an heavy-ion collision. Chapter 2 gives some insight into the design. The main tracking detector is the Time Projection Chamber (TPC). It has more than half million read-out channels, divided into 216 Read-out Partitions (RPs). Each RP is a separate Front-End Electronics (FEE) entity, as described in Chapter 3. A complex Detector Control System (DCS) is needed for configuration, monitoring and control. The heart of it on the RP side is a small embedded ...

  18. Immunohistochemical expression of MMP-14 and MMP-2, and MMP-2 activity during human ovarian follicular development

    NARCIS (Netherlands)

    Vos, M.C.; Wurff, A.A. van der; Last, J.T.; Boed, E.A. de; Smeenk, J.M.J.; Kuppevelt, T.H. van; Massuger, L.F.A.G.

    2014-01-01

    BACKGROUND: The aim of this study was to investigate the presence of MMP-14 and MMP-2 during human ovarian follicular development using immunohistochemistry, and the activity of MMP-2 in follicular fluid using zymography. METHODS: Ovarian tissue collected from the archives of the Department of Patho

  19. Inventory of current environmental monitoring projects in the US-Canadian transboundary region

    Energy Technology Data Exchange (ETDEWEB)

    Glantz, C.S.; Ballinger, M.Y.; Chapman, E.G.

    1986-05-01

    This document presents the results of a study commissioned to survey and summarize major environmental monitoring projects in the US-Canadian transboundary region. Projects with field sites located within 400 km (250 mi) of the border and active after 1980 were reviewed. The types of projects included: ambient air-quality monitoring, ambient water-quality monitoring, deposition monitoring, forest/vegetation monitoring and research, soil studies, and ecosystem studies. Ecosystem studies included projects involving the measurement of parameters from more than one monitoring category (e.g., studies that measured both water and soil chemistry). Individual descriptions were formulated for 184 projects meeting the spatial and temporal criteria. Descriptions included the official title for the project, its common abbreviation, program emphasis, monitoring site locations, time period conducted, parameters measured, protocols employed, frequency of sample collection, data storage information, and the principal contact for the project. A summary inventory subdivided according to the six monitoring categories was prepared using a computerized data management system. Information on major centralized data bases in the field of environmental monitoring was also obtained, and summary descriptions were prepared. The inventory and data base descriptions are presented in appendices to this document.

  20. Wearable Beat to Beat Blood Pressure Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — A key component of NASA's human exploration programs is a system that monitors the health of the crew during the space missions. The wearable physiological monitor...

  1. Biomedical Monitoring by a Novel Noncontact Radio Frequency Technology Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This technology will be a quantum advance in cardiac monitoring and will be applicable in numerous situations such as for immediate assessment and monitoring of...

  2. Characterization of Electrospray Ionization for Spaceflight Water Monitoring Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Current methods for monitoring the water used on the ISS rely heavily on ground analysis of archival samples. Air monitors presently on board the ISS could be used...

  3. Improvement in RUP Project Management via Service Monitoring: Best Practice of SOA

    CERN Document Server

    Saqib, Sheikh Muhammad; Hussain, Shahid; Ahmad, Bashir; Bano, Arjamand

    2010-01-01

    Management of project planning, monitoring, scheduling, estimation and risk management are critical issues faced by a project manager during development life cycle of software. In RUP, project management is considered as core discipline whose activities are carried in all phases during development of software products. On other side service monitoring is considered as best practice of SOA which leads to availability, auditing, debugging and tracing process. In this paper, authors define a strategy to incorporate the service monitoring of SOA into RUP to improve the artifacts of project management activities. Moreover, the authors define the rules to implement the features of service monitoring, which help the project manager to carry on activities in well define manner. Proposed frame work is implemented on RB (Resuming Bank) application and obtained improved results on PM (Project Management) work.

  4. Pros-IT CNR: an Italian prostate cancer monitoring project.

    Science.gov (United States)

    Noale, Marianna; Maggi, Stefania; Artibani, Walter; Bassi, Pier Francesco; Bertoni, Filippo; Bracarda, Sergio; Conti, Giario Natale; Corvò, Renzo; Gacci, Mauro; Graziotti, Pierpaolo; Magrini, Stefano Maria; Maurizi Enrici, Riccardo; Mirone, Vincenzo; Montironi, Rodolfo; Muto, Giovanni; Pecoraro, Stefano; Porreca, Angelo; Ricardi, Umberto; Tubaro, Andrea; Zagonel, Vittorina; Zattoni, Filiberto; Crepaldi, Gaetano

    2017-04-01

    The Pros-IT CNR project aims to monitor a sample of Italian males ≥18 years of age who have been diagnosed in the participating centers with incident prostate cancer, by analyzing their clinical features, treatment protocols and outcome results in relation to quality of life. Pros-IT CNR is an observational, prospective, multicenter study. The National Research Council (CNR), Neuroscience Institute, Aging Branch (Padua) is the promoting center. Ninety-seven Italian centers located throughout Italy were involved. The field study began in September 1, 2014. Subjects eligible were diagnosed with biopsy-verified prostate cancer, naïve. A sample size of 1500 patients was contemplated. A baseline assessment including anamnestic data, clinical history, risk factors, the initial diagnosis, cancer staging information and quality of life (Italian UCLA Prostate Cancer Index; SF-12 Scale) was completed. Six months after the initial diagnosis, a second assessment evaluating the patient's health status, the treatment carried out, and the quality of life will be made. A third assessment, evaluating the treatment follow-up and the quality of life, will be made 12 months after the initial diagnosis. The 4th, 5th, 6th and 7th assessments, similar to the third, will be completed 24, 36, 48 and 60 months after the initial diagnosis, respectively, and will include also a Food Frequency Questionnaire and the Physical Activity Scale for the Elderly. The study will provide information on patients' quality of life and its variations over time in relation to the treatments received for the prostate cancer.

  5. Effective Monitoring and Control of Outsourced Software Development Projects

    NARCIS (Netherlands)

    Ponisio, Laura; Vruggink, P.

    2011-01-01

    In our study of four outsourcing projects we discover mechanisms to support managerial decision making during software development processes. We report on Customer Office, a framework used in practice that facilitates reasoning about projects by highlighting information paths and making

  6. Hematopoietic Stem Cell Mobilization and Homing after Transplantation: The Role of MMP-2, MMP-9, and MT1-MMP

    Directory of Open Access Journals (Sweden)

    Neeta Shirvaikar

    2012-01-01

    Full Text Available Hematopoietic stem/progenitor cells (HSPCs are used in clinical transplantation to restore hematopoietic function. Here we review the role of the soluble matrix metalloproteinases MMP-2 and MMP-9, and membrane type (MT1-MMP in modulating processes critical to successful transplantation of HSPC, such as mobilization and homing. Growth factors and cytokines which are employed as mobilizing agents upregulate MMP-2 and MMP-9. Recently we demonstrated that MT1-MMP enhances HSPC migration across reconstituted basement membrane, activates proMMP-2, and contributes to a highly proteolytic bone marrow microenvironment that facilitates egress of HSPC. On the other hand, we reported that molecules secreted during HSPC mobilization and collection, such as hyaluronic acid and thrombin, increase MT1-MMP expression in cord blood HSPC and enhance (prime their homing-related responses. We suggest that modulation of MMP-2, MMP-9, and MT1-MMP expression has potential for development of new therapies for more efficient mobilization, homing, and engraftment of HSPC, which could lead to improved transplantation outcomes.

  7. A Mega-project on Space Weather Monitoring Gets the Green Light

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ A 200-million-yuan ($25 million) mega-project of science research on space weather monitoring, namely the Meridian Space Weather Moni toting Project (Meridian Project for short), proposed by several research institutes and universities in China has been approved recently by the Chinese government.

  8. Adding Shareholder Value through Project Performance Measurement, Monitoring & Control

    NARCIS (Netherlands)

    M.M. Akalu; J.R. Turner (Rodney)

    2002-01-01

    textabstractWe present the various views and methods of measuring and controlling project performance, and factors affecting a project. The review indicates that there is a shift in the type and understanding of factors of project success or failure. However, the presence of various measurement meth

  9. Amsacrine suppresses matrix metalloproteinase-2 (MMP-2)/MMP-9 expression in human leukemia cells.

    Science.gov (United States)

    Liu, Wen-Hsin; Chen, Ying-Jung; Chien, Jen-Hung; Chang, Long-Sen

    2014-05-01

    This study explores the suppression mechanism of amsacrine (4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride) on matrix metalloproteinase-2 (MMP-2) and MMP-9 expression in human leukemia cells. Amsacrine attenuated cell invasion with decreased MMP-2/MMP-9 protein expression and mRNA levels in U937, Jurkat, HL-60, K562, KU812, and MEG-01 cells. Moreover, amsacrine reduced both MMP-2/MMP-9 promoter luciferase activity and MMP-2/MMP-9 mRNA stability in leukemia cells. Studies on amsacrine-treated U937 cells revealed that amsacrine-elicited ROS generation induced JNK and p38 MAPK activation but reduced the phospho-ERK level. Amsacrine-induced ERK inactivation and p38 MAPK/JNK activation were demonstrated to suppress MMP-2/MMP-9 promoter luciferase activity and promote MMP-2/MMP-9 mRNA decay, respectively. p38 MAPK/JNK activation led to up-regulation of protein phosphatase 2A catalytic subunit α (PP2Acα) in amsacrine-treated U937 cells. Okadaic acid (PP2A inhibitor) treatment increased MMP-2/MMP-9 mRNA stability in amsacrine-treated cells, whereas PP2Acα over-expression increased MMP-2/MMP-9 mRNA decay. Amsacrine-induced MMP-2/MMP-9 down-regulation was also related to PP2Acα up-regulation on Jurkat, HL-60, K562, KU812, and MEG-01 cells. Collectively, our data indicate that amsacrine induces MMP-2/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability in human leukemia cells.

  10. Clinical and behavioral characteristics of adults receiving medical care for HIV infection --- Medical Monitoring Project, United States, 2007.

    Science.gov (United States)

    Blair, Janet M; McNaghten, A D; Frazier, Emma L; Skarbinski, Jacek; Huang, Ping; Heffelfinger, James D

    2011-09-02

    As of December 31, 2008, an estimated 663,084 persons were living with a diagnosis of human immunodeficiency virus (HIV) infection in the 40 U.S. states that have had confidential name-based HIV infection reporting since at least January 2006. Although HIV surveillance programs in the United States collect information about persons who have received a diagnosis of HIV infection and acquired immunodeficiency syndrome (AIDS), supplemental surveillance projects are needed to collect information about care-seeking behaviors, health-care use, and other behaviors among persons living with HIV. Data on the clinical and behavioral characteristics of persons receiving medical care for HIV infection are critical to reduce HIV-related morbidity and mortality and for program planning to allocate services and resources, guide prevention planning, assess unmet medical and ancillary service needs, and help develop intervention programs and health policies at the local, state, and national levels. Data were collected during June 2007-September 2008 for patients who received medical care in 2007 (sampled from January 1-April 30). The Medical Monitoring Project (MMP) is an ongoing, multisite supplemental surveillance project that assesses behaviors, clinical characteristics, and quality of care of HIV-infected persons who are receiving medical care. Participants must be aged ≥ 18 years and have received medical care at sampled facilities that provide HIV medical care within participating MMP project areas. Self-reported behavioral and selected clinical data are collected using an in-person interview. A total of 26 project areas in 19 states and Puerto Rico were funded to collect data during the 2007 MMP data collection cycle. The results from the 2007 MMP cycle indicated that among 3,643 participants, a total of 3,040 (84%) had some form of health insurance or coverage during the 12 months before the interview; of these, 45% reported having Medicaid, 37% reported having private

  11. Dimerization of matrix metalloproteinase-2 (MMP-2): functional implication in MMP-2 activation.

    Science.gov (United States)

    Koo, Bon-Hun; Kim, Yeon Hyang; Han, Jung Ho; Kim, Doo-Sik

    2012-06-29

    Matrix metalloproteinase-2 (MMP-2) functions in diverse biological processes through the degradation of extracellular and non-extracellular matrix molecules. Because of its potential for tissue damage, there are several ways to regulate MMP-2 activity, including gene expression, compartmentalization, zymogen activation, and enzyme inactivation by extracellular inhibitors. Enzyme regulation through zymogen activation is important for the regulation of MMP-2 activity. In our previous studies, we showed that thrombin directly cleaved the propeptide of MMP-2 at specific sites for enzyme activation. We also demonstrated that heparan sulfate was required for thrombin-mediated activation of pro-MMP-2 by binding to thrombin, presumably through conformational changes at the active site of the enzyme. This suggests a regulatory mechanism for thrombin-mediated activation of pro-MMP-2. In this study, we found that MMP-2 formed a reduction-sensitive homodimer in a controlled manner and that Ca(2+) ion was essential for homodimerization of MMP-2. Homodimerization was not associated with protein kinase C-mediated phosphorylation of MMP-2. MMP-2 formed a homodimer through an intermolecular disulfide bond between Cys(102) and the neighboring Cys(102). Homodimerization of MMP-2 enhanced thrombin-mediated activation of pro-MMP-2. Moreover, the MMP-2 homodimer could cleave a small peptide substrate without removal of the propeptide. Taken together, our experimental data suggest a novel regulatory mechanism for pro-MMP-2 activation that is modulated through homodimerization of MMP-2.

  12. NDE and Stress Monitoring on Composite Overwrapped Pressure Vessels Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Damage caused by composite overwrapped pressure vessels (COPVs) failure can be catastrophic. Thus, monitoring condition and stress in the composite overwrap,...

  13. Compact Monitor for Airborne Carbon Dioxide Measurements Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Eltron Research & Development proposes the development of a lightweight, battery-powered instrument for accurately and rapidly monitoring the local concentration...

  14. Developing an Integrated Monitoring and Evaluation Flow for Sustainable Investment Projects

    Directory of Open Access Journals (Sweden)

    Florin TACHE

    2011-12-01

    Full Text Available Under the circumstances of certain weaknesses in the monitoring and evaluation processes of sustainable investment projects, the paper aims to develop a general integrated flow, encompassing both a project monitoring system and also a project evaluation system for the investment projects involving economic objectives, as well as cross-cutting social and environmental targets. The whole approach is being presented as a flowchart, which highlights the intimate relationship between the monitoring and evaluation processes, and provides a formal framework for performing a logical monitoring and evaluation process, taking into account simultaneously the economic, social and environmental perspectives, within an investment project. Last, but not least, the article states both the estimated advantages and the disadvantages of such a managerial tool, opening new perspectives for developing further improved models and systems.

  15. MMP-2和MMP-9在肺癌组织中的表达%Expression of MMP-2 and MMP-9 in Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    孙书明; 周妍; 罗金芳; 桂律; 胡志雄; 金盈; 金复生

    2003-01-01

    目的:研究肺癌和正常肺组织中基质金属蛋白酶2 (MMP-2)和MMP-9的表达.方法:采用免疫组织化学EnVision方法, 对71例肺癌标本和31例正常肺组织检测MMP-2和MMP-9的表达.结果:71例肺癌标本中,小细胞肺癌(SCLC)4例,MMP-2表达阳性3例(75.0%),MMP-9表达阳性2例(50.0%);非小细胞肺癌(NSCLC)有67例,年龄40岁以上64例,MMP-2表达阳性39例,阳性率60.9%(39/64);MMP-9表达阳性46例,阳性率71.9%(46/64).正常肺标本31例,年龄40岁以下MMP-2和MMP-9表达均为阴性,年龄在40岁以上26例,MMP-2阳性表达9例,阳性率34.6%(9/26),MMP-9阳性表达10例,阳性率38.5%(10/26);40岁以上NSCLC标本的MMP-2和MMP-9阳性表达与正常肺标本比较,差异均有显著意义.结论:在NSCLC中高表达的MMP-2和MMP-9均是好的肿瘤标记物,但是,MMP-9阳性率比MMP-2更高,因此MMP-9的检测具有更大的临床意义.

  16. Explanation of the project - The Rice Growth Monitoring for The Phenotypic Functional Analysis | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available The Rice Growth Monitoring for The Phenotypic Functional Analysis Explanation of the project Data detail Dat...tion of the project - The Rice Growth Monitoring for The Phenotypic Functional Analysis | LSDB Archive ...

  17. Composite Overwrapped Pressure Vessels (COPV) Monitoring System Using Fiber Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Intelligent Fiber Optic Systems Corporation (IFOS) proposes, in this Phase 1 SBIR project, to demonstrate the feasibility of innovations based on an...

  18. The role of MT2-MMP in cancer progression

    Energy Technology Data Exchange (ETDEWEB)

    Ito, Emiko [Department of Molecular Pathology, Graduate School of Medicine and Health Sciences, Osaka University, Suita, Osaka 565-0871 (Japan); Yana, Ikuo [Department of Molecular Pathology, Graduate School of Medicine and Health Sciences, Osaka University, Suita, Osaka 565-0871 (Japan); Takeda Pharmaceutical Co. Ltd., Japan Development Center, Osaka 540-8645 (Japan); Fujita, Chisato; Irifune, Aiko; Takeda, Maki; Madachi, Ayako; Mori, Seiji; Hamada, Yoshinosuke; Kawaguchi, Naomasa [Department of Molecular Pathology, Graduate School of Medicine and Health Sciences, Osaka University, Suita, Osaka 565-0871 (Japan); Matsuura, Nariaki, E-mail: Matsuura@sahs.med.osaka-u.ac.jp [Department of Molecular Pathology, Graduate School of Medicine and Health Sciences, Osaka University, Suita, Osaka 565-0871 (Japan)

    2010-03-05

    The role of MT2-MMP in cancer progression remains to be elucidated in spite of many reports on MT1-MMP. Using a human fibrosarcoma cell, HT1080 and a human gastric cancer cell, TMK-1, endogenous expression of MT1-MMP or MT2-MMP was suppressed by siRNA induction to examine the influence of cancer progression in vitro and in vivo. In HT1080 cells, positive both in MT1-MMP and MT2-MMP, the migration as well as the invasion was impaired by MT1-MMP or MT2-MMP suppression. Also cell proliferation in three dimensional (3D) condition was inhibited by MT1-MMP or MT2-MMP suppression and tumor growth in the nude mice transplanted with tumor cells were reduced either MT1-MMP or MT2-MMP suppression with a prolongation of survival time in vivo. MT2-MMP suppression induces more inhibitory effects on 3D proliferation and in vivo tumor growth than MT1-MMP. On the other hand, TMK-1 cells, negative in MT1-MMP and MMP-2 but positive in MT2-MMP, all the migratory, invasive, and 3D proliferative activities in TMK-1 are decreased only by MT2-MMP suppression. These results indicate MT2-MMP might be involved in the cancer progression more than or equal to MT1-MMP independently of MMP-2 and MT1-MMP.

  19. High Performance Fiber-Optic Sensor for Environmental Monitoring Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Los Gatos Research (LGR) proposes to develop a low-cost, compact, lightweight, rugged and easy-to-use environmental monitoring optical fiber sensor device based on...

  20. Aircraft Control Augmentation and Health Monitoring Using FADS Technology Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I research proposal is aimed at demonstrating the feasibility of an innovative architecture comprising control augmentation and on-line health monitoring...

  1. Distributed Rocket Engine Testing Health Monitoring System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Leveraging the Phase I achievements of the Distributed Rocket Engine Testing Health Monitoring System (DiRETHMS) including its software toolsets and system building...

  2. Community air monitoring and the Village Green Project

    Science.gov (United States)

    Cost and logistics are practical issues that have historically constrained the number of locations where long-term, active air pollution measurement is possible. In addition, traditional air monitoring approaches are generally conducted by technical experts with limited engageme...

  3. Improved Combustion Products Monitor for the ISS Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Compound Specific Analyzer – Combustion Products, used on the International Space Station as a warning monitor of smoldering or combustion events, is being...

  4. Distributed Rocket Engine Testing Health Monitoring System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The on-ground and Distributed Rocket Engine Testing Health Monitoring System (DiRETHMS) provides a system architecture and software tools for performing diagnostics...

  5. Non-linear Ultrasonic Bond-Strength Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — To date, bond strength is considered one of the ?holy grails? for NDE. Preliminary data indicates that the Luna Nonlinear Ultrasonic Bond Strength (NUBS) monitor...

  6. Novel Real-Time Flight Envelope Monitoring System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed innovation is an aircraft flight envelope monitoring system that will provide real-time in-cockpit estimations of aircraft flight envelope boundaries,...

  7. Community air monitoring and the Village Green Project

    Science.gov (United States)

    Abstract: Cost and logistics are practical issues that have historically constrained the number of locations where long-term, active air pollution measurement is possible. In addition, traditional air monitoring approaches are generally conducted by technical experts with limite...

  8. Novel Real-Time Flight Envelope Monitoring System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed innovation is an aircraft flight envelope monitoring system that will provide real-time in-cockpit estimations of aircraft flight envelope boundaries....

  9. Improved Combustion Products Monitor for the ISS Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Compound Specific Analyzer - Combustion Products is used on the International Space Station as a warning monitor of smoldering or combustion events and, after...

  10. Multi-Modal Neurodiagnostic Tool for Stress Monitoring Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA has a requirement for a neurodiagnostic tool that can be used to monitor the behavioral health of the crew during long duration Exploration missions. The device...

  11. Water chemistry - Thornton Creek Restoration Project Effectiveness Monitoring

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA has designed and is currently implementing a hyporheic monitoring plan for the Thornton Creek watershed in North Seattle. This work is being conducted for...

  12. Micro GC's for Contaminant Monitoring in Spacecraft Air Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this proposal is to create new gas chromatographs (GCs) for contaminant monitoring in spacecraft air that do not require any reagents or special...

  13. Wearable Beat to Beat Blood Pressure Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — A key component of NASA's human exploration programs is a system that monitors the health of the crew during space missions. The wearable beat-to-beat blood pressure...

  14. Aquatic Invertebrates - Thornton Creek Restoration Project Effectiveness Monitoring

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA has designed and is currently implementing a hyporheic monitoring plan for the Thornton Creek watershed in North Seattle. This work is being conducted for...

  15. Novel Non-Intrusive Vibration Monitoring System for Turbopumps Project

    Data.gov (United States)

    National Aeronautics and Space Administration — ASRI proposes to develop an advanced and commercially viable Non-Intrusive Vibration Monitoring System (NI-VMS) which can provide effective on-line/off-line engine...

  16. In-Situ Monitoring of Immune Function Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Monitoring the health and wellness of mission pilots is a critically important function. Space flight has an adverse effect on the human immune response. During...

  17. Passive Wireless Sensor System for Structural Health Monitoring Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Albido proposes to develop a Passive Wireless Sensor System for Structural Health Monitoring capable of measuring high-bandwidth temperature and strain of space and...

  18. High-Performance Contaminant Monitor for Spacecraft Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Vision for Space Exploration demands increasing reliance on real-time trace gas monitors onboard spacecraft. Present grab samples and badges will be inadequate...

  19. On-Orbit Health Monitoring and Repair Assessment of Thermal Protection Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR project delivers On-orbit health MoNItoring and repair assessment of THERMal protection systems (OMNI_THERM). OMNI_THERM features impedance-based...

  20. Autonomus I&C Maintenance and Health Monitoring System for Fission Surface Power Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The primary goal of this project is to design and develop an autonomous instrumentation and control (I&C) health monitoring system for space nuclear power...

  1. Data Analysis Algorithm Suitable for Structural Health Monitoring Based on Dust Network Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposed project will attempt to develop a data analysis system for structural health monitoring on space structures. The data analysis software will be a key...

  2. Wireless Health Monitoring for Large Arrays of MEMS Sensors and Actuators Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this Phase I project is to demonstrate an automated on-line structural health monitoring system for aircraft structures using a combination of...

  3. Prime Hook NWR Marsh Restoration Project Summary & Monitoring Plan 2015

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This living document provides a condensed explanation of wetland management history and a large-scale tidal marsh restoration project at Prime Hook NWR in Delaware....

  4. LCREP growth rates - Lower Columbia River Ecosystem Monitoring Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — 1) The purpose of this project is to document juvenile salmon habitat occurrence in the Lower Columbia River and estuary, and examine how habitat conditions...

  5. LCREP chemistry and lipids - Lower Columbia River Ecosystem Monitoring Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — 1) The purpose of this project is to document juvenile salmon habitat occurrence in the Lower Columbia River and estuary, and examine how habitat conditions...

  6. LCREP catch records - Lower Columbia River Ecosystem Monitoring Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — 1) The purpose of this project is to document juvenile salmon habitat occurrence in the Lower Columbia River and estuary, and examine how habitat conditions...

  7. LCREP genetic stock ID - Lower Columbia River Ecosystem Monitoring Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — 1) The purpose of this project is to document juvenile salmon habitat occurrence in the Lower Columbia River and estuary, and examine how habitat conditions...

  8. LCREP prey data - Lower Columbia River Ecosystem Monitoring Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — 1) The purpose of this project is to document juvenile salmon habitat occurrence in the Lower Columbia River and estuary, and examine how habitat conditions...

  9. 7 CFR 3405.19 - Monitoring progress of funded projects.

    Science.gov (United States)

    2010-01-01

    ... RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE HIGHER EDUCATION CHALLENGE GRANTS... Annual Performance Reports should include a summary of the overall progress toward project objectives... reform, and opportunities to enhance dissemination of exemplary end products/results. (b) An...

  10. 7 CFR 3406.26 - Monitoring progress of funded projects.

    Science.gov (United States)

    2010-01-01

    ... award. These reports are in addition to the annual Current Research Information System (CRIS) reports... RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE 1890 INSTITUTION CAPACITY BUILDING... Annual Performance Reports should include a summary of the overall progress toward project...

  11. In-Process Monitoring of Additive Manufacturing Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The key innovation in this project is the implementation of an Imaging Fourier Transform Spectrometer (IFTS) for in situ metal additive manufacturing process...

  12. Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2.

    Science.gov (United States)

    Nishida, Yuki; Miyamori, Hisashi; Thompson, Erik W; Takino, Takahisa; Endo, Yoshio; Sato, Hiroshi

    2008-11-01

    The suggested model for pro-matrix metalloproteinase-2 (proMMP-2) activation by membrane type 1 MMP (MT1-MMP) implicates the complex between MT1-MMP and tissue inhibitor of MMP-2 (TIMP-2) as a receptor for proMMP-2. To dissect this model and assess the pathologic significance of MMP-2 activation, an artificial receptor for proMMP-2 was created by replacing the signal sequence of TIMP-2 with cytoplasmic/transmembrane domain of type II transmembrane mosaic serine protease (MSP-T2). Unlike TIMP-2, MSP-T2 served as a receptor for proMMP-2 without inhibiting MT1-MMP, and generated TIMP-2-free active MMP-2 even at a low level of MT1-MMP. Thus, MSP-T2 did not affect direct cleavage of the substrate testican-1 by MT1-MMP, whereas TIMP-2 inhibited it even at the level that stimulates proMMP-2 processing. Expression of MSP-T2 in HT1080 cells enhanced MMP-2 activation by endogenous MT1-MMP and caused intensive hydrolysis of collagen gel. Expression of MSP-T2 in U87 glioma cells, which express a trace level of endogenous MT1-MMP, induced MMP-2 activation and enhanced cell-associated protease activity, activation of extracellular signal-regulated kinase, and metastatic ability into chick embryonic liver and lung. MT1-MMP can exert both maximum MMP-2 activation and direct cleavage of substrates with MSP-T2, which cannot be achieved with TIMP-2. These results suggest that MMP-2 activation by MT1-MMP potentially amplifies protease activity, and combination with direct cleavage of substrate causes effective tissue degradation and enhances tumor invasion and metastasis, which highlights the complex role of TIMP-2. MSP-T2 is a unique tool to analyze physiologic and pathologic roles of MMP-2 and MT1-MMP in comparison with TIMP-2.

  13. Quality assurance project plan for ground water monitoring activities managed by Westinghouse Hanford Company. Revision 3

    Energy Technology Data Exchange (ETDEWEB)

    Stauffer, M.

    1995-11-01

    This quality assurance project plan (QAPP) applies specifically to the field activities and laboratory analysis performed for all RCRA groundwater projects conducted by Hanford Technical Services. This QAPP is generic in approach and shall be implemented in conjunction with the specific requirements of individual groundwater monitoring plans.

  14. REDD+ readiness: early insights on monitoring, reporting and verification systems of project developers

    NARCIS (Netherlands)

    Joseph, S.; Herold, M.; Sunderlin, W.D.; Verchot, L.V.

    2013-01-01

    A functional measuring, monitoring, reporting and verification (MRV) system is essential to assess the additionality and impact on forest carbon in REDD+ (reducing emissions from deforestation and degradation) projects. This study assesses the MRV capacity and readiness of project developers at 20 R

  15. Manual on SFR R and D and Technology Monitoring System Based on Enterprise Project Management Solution

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Dong Uk; Lee, Yong Bum; Won, Byung Chool; Kim, Young In; Hahn, Do Hee

    2008-04-15

    This report is a manual on enterprise project management solution for R and D and technology monitoring system that is applicable for managing the generation IV sodium-cooled fast reactor development. The prime goal of this system is to provide project manager with reliable and accurate information of status of progress, performance and resource allocation, and attain traceability and visibility of project implementation for effective project management. This report is composed of the three part. The first part is an introduction on microsoft project professional software that was used to monitor the progress, evaluate the results and analyze the resource distribution of the activities. The second makes a description of project plan and control, and the third part describes on collaboration and teamwork.

  16. Remote instrumentation and safeguards monitoring for the star project

    Energy Technology Data Exchange (ETDEWEB)

    Buettner, H M; Labiak, W; Spiridon, A

    2000-06-15

    A part of the Nuclear Energy Research Initiative (NERI) is the development of the Small Transportable Autonomous Reactor (STAR) for deployment in countries that do not have a nuclear industry. STARs would have an output of from 100 to 150 MW electric, would be fueled in the country of manufacture, and after 15 to 20 years of operation the reactor core would be returned to the country of manufacture for refueling. A candidate STAR design can be found in (Greenspan, 2000). This paper describes the design of the control and monitoring system that might be used. There are two unique features to this system. One is that the monitored information will be transmitted to a remote site for two purposes, safeguards, and allowing experts a great distance away direct access to view the reactor's operating parameters. The second feature is safeguards sensors will be designed into the system and there will monitoring of the safeguards aspects of the system for tampering. Any safeguards anomalies will be sent to the remote site as alarms. Encrypted satellite communications will be used to transmit the data. These features allow the STAR to be operated by a small staff and will reduce the costs of safeguards monitoring by reducing the number of plant visits by inspectors.

  17. Nova Scotia S-2000 monitoring project. Vol. 1, Performance summary

    Energy Technology Data Exchange (ETDEWEB)

    Makuch, P.; Harrison, S.J. [Queen`s Univ., Kingston, ON (Canada). Solar Calorimetry Lab.

    1994-12-01

    Electric utility companies have increasingly been evaluating and implementing demand management and conservation. As a result there has been growing interest in potential energy savings and capacity benefits of Solar Domestic Hot Water (SDHW) technologies. A computer simulation study showed that SDHW can provide significant savings in hot water heating. Natural Resources Canada through the Canada Centre for Mineral and Energy Technology (CANMET) initiated the S-2000 program. The S-2000 program was initiated to promote cooperation between CANMET, electric utilities and provincial governments interested in determining whether SDHW systems can reduce peak energy demand and pollution emissions. 60 SDHW systems were installed in Nova Scotia. Systems were monitored by Thermo Dynamics Limited and analyzed by the Solar Calorimetry Laboratory at Queen`s University. Results were produced for the monitoring period from October 1993 to August 1994. Results for 32 of the Nova Scotia systems showed winter and summer solar energy supplies of 14.8 MWh and 30 MWh respectively. The system efficiency was determined to be 28.4%. The system performance was consistent with predictions made from computer simulations, with the exception of an unexpectedly severe winter. The solar energy contribution during the winter was lower than that predicted for typical weather conditions. Of the systems monitored daily average hot water use was lower than the reference 239 L/day value. Monitoring of the Nova Scotia systems will continue through 1995 and strategies will be investigated. 15 figs., 5 tables

  18. Monitoring and Evaluation of Soil Conversation and Watershed Development Projects

    NARCIS (Netherlands)

    Graaff, de J.; Cameron, J.; Sombatpani, S.; Pieri, C.; Woodhill, A.J.

    2007-01-01

    Part One of this book introduces the challenges of monitoring and evaluating interventions designed by technical experts meeting the needs of people who actually use the environment which the interventions are seeking to modify. The chapters in this section seek reconciliation of these tensions thro

  19. Remote instrumentation and safeguards monitoring for the star project

    Energy Technology Data Exchange (ETDEWEB)

    Buettner, H M; Labiak, W; Spiridon, A

    2000-06-15

    A part of the Nuclear Energy Research Initiative (NERI) is the development of the Small Transportable Autonomous Reactor (STAR) for deployment in countries that do not have a nuclear industry. STARs would have an output of from 100 to 150 MW electric, would be fueled in the country of manufacture, and after 15 to 20 years of operation the reactor core would be returned to the country of manufacture for refueling. A candidate STAR design can be found in (Greenspan, 2000). This paper describes the design of the control and monitoring system that might be used. There are two unique features to this system. One is that the monitored information will be transmitted to a remote site for two purposes, safeguards, and allowing experts a great distance away direct access to view the reactor's operating parameters. The second feature is safeguards sensors will be designed into the system and there will monitoring of the safeguards aspects of the system for tampering. Any safeguards anomalies will be sent to the remote site as alarms. Encrypted satellite communications will be used to transmit the data. These features allow the STAR to be operated by a small staff and will reduce the costs of safeguards monitoring by reducing the number of plant visits by inspectors.

  20. MMP3 — EDRN Public Portal

    Science.gov (United States)

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP3 degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

  1. Serum level of MMP-2, MMP-9 and Ox-LDL in Alzheimer's disease with hyperlipoidemia

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective:To investigate serum levels of MMP-2,MMP-9, oxidized low density lipoprotein (ox-LDL) in Alzheimer's disease (AD) patients and study the possible pathway and mechanism of AD with abnormal lipid metabolism. Methods: Subjects in this study were divided into 4 groups: normal lipid group without AD (N), hyperlipoidemia group without AD (H), normal group with AD (A), hyperlipoidemia group with AD (AH). There were 15 individuals in each group. MMP-2, MMP-9, ox-LDL was measured by enzyme linked immunosorbent assay (ELISA). Serum lipids levels were measured by biochemical methods. Results: The serum levels of MMP-2, MMP-9, ox-LDL were significantly higher in H, A and AH groups than those in N group. Those of ox LDL in H, AH groups was higher than that of in A group. The serum level of MMP-2, MMP-9 in AH groups were higher than that of in H group. The score of mini-mental state examination (MMSE) in A and AD groups was negatively correlated with the serum level of ox-LDL. Relationship between the score of MMSE and the serum level of ox-LDL in AD groups and non-AD groups had statistical significance. Conclusion: MMP-2, MMP-9, ox-LDL and abnormal lipid metabolism may participate in pathogenesis of AD, in which abnormal lipid metabolism induces expressions of MMP-2,MMP-9 and ox-LDL. Oxidative stress and blood-brain barrier disruption might accelerate the process of AD.

  2. The Web Based Monitoring Project at the CMS Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Perez, Juan Antonio [Fermilab; Badgett, William [Fermilab; Behrens, Ulf [DESY; Chakaberia, Irakli [Kansas State U.; Jo, Youngkwon [Korea U.; Maeshima, Kaori; Maruyama, Sho [Fermilab; Patrick, James [Fermilab; Rapsevicius, Valdas [Fermilab; Soha, Aron [Fermilab; Stankevicius, Mantas [Fermilab; Sulmanas, Balys [Fermilab; Toda, Sachiko [Kansas State U.; Wan, Zongru [Kansas State U.

    2016-01-01

    The Compact Muon Solenoid is a large a complex general purpose experiment at the CERN Large Hadron Collider (LHC), built and maintained by many collaborators from around the world. Efficient operation of the detector requires widespread and timely access to a broad range of monitoring and status information. To the end the Web Based Monitoring (WBM) system was developed to present data to users located anywhere from many underlying heterogeneous sources, from real time messaging systems to relational databases. This system provides the power to combine and correlate data in both graphical and tabular formats of interest to the experimenters, including data such as beam conditions, luminosity, trigger rates, detector conditions, and many others, allowing for flexibility on the user’s side. This paper describes the WBM system architecture and describes how the system has been used from the beginning of data taking until now (Run1 and Run 2).

  3. All Sky Cloud Coverage Monitoring for SONG-China Project

    Science.gov (United States)

    Tian, J. F.; Deng, L. C.; Yan, Z. Z.; Wang, K.; Wu, Y.

    2016-05-01

    In order to monitor the cloud distributions at Qinghai station, a site selected for SONG (Stellar Observations Network Group)-China node, the design of the proto-type of all sky camera (ASC) applied in Xinglong station is adopted. Both hardware and software improvements have been made in order to be more precise and deliver quantitative measurements. The ARM (Advanced Reduced Instruction Set Computer Machine) MCU (Microcontroller Unit) instead of PC is used to control the upgraded version of ASC. A much higher reliability has been realized in the current scheme. Independent of the positions of the Sun and Moon, the weather conditions are constantly changing, therefore it is difficult to get proper exposure parameters using only the temporal information of the major light sources. A realistic exposure parameters for the ASC can actually be defined using a real-time sky brightness monitor that is also installed at the same site. The night sky brightness value is a very sensitive function of the cloud coverage, and can be accurately measured by the sky quality monitor. We study the correlation between the exposure parameter and night sky brightness value, and give the mathematical relation. The images of the all sky camera are inserted into database directly. All sky quality images are archived in FITS format which can be used for further analysis.

  4. MMP-2和MMP-9在食管癌中表达的研究%Expressions of MMP-2 and MMP-9 in esophageal cancer

    Institute of Scientific and Technical Information of China (English)

    武志; 潘晓玲; 仲洁

    2013-01-01

    目的 分析基质金属蛋白酶(MMP)-2和MMP-9在食管癌患者血清中的表达与食管癌临床病理因素之间的关系.方法 应用酶联免疫吸附法检测60例食管癌患者血清中MMP-2、MMP-9的含量与患者年龄、性别、组织学类型、临床分期及区域淋巴结转移等临床病理因素之间的关系.结果 对照组血清中MMP-2和MMP-9的浓度均值分别为61.31、87.67 ng/ml,而食管癌患者血清中MMP-2和MMP-9的浓度均值分别121.66、169.73 ng/ml,均高于正常者血清中含量,差异有统计学意义(t=3.015,P=0.007;t=2.037,P=0.04).MMP-2的含量与有无淋巴结转移(t=2.150,P=0.04)及临床分期(t=2.186,P=0.03)有关,MMP-9的含量与有无淋巴结转移(t=2.390,P=0.02)及临床分期(t=2.149,P=0.03)有关.MMP-2和MMP-9的含量均与食管癌患者的年龄、性别、组织学类型无关(均P>0.05).结论 MMP-2和MMP-9可能与食管癌的侵袭转移有关.%Objective To analyze the expression levels of matrix metallo proteinase-2 (MMP-2) and matrix metallo proteinase-9 (MMP-9) in serum of patients with esophageal cancer,and to analyze the interrelations among MMP-2,MMP-9 and clinicopathologic characteristics of esophageal cancer.Methods The levels of serum MMP-2,MMP-9 from 60 patients with esophageal cancer were detected by enzyme linked immunosorbent assay.The interrelations among MMP-2,MMP-9 and clinicopathologic characteristics of esophageal cancer including age,gender,histological type,whether or not lymph nodes metastasis and TNM staging were analyzed.Results The levels of MMP-2 and MMP-9 in control group were 61.31 ng/ml and 87.67 ng/ml,the levels of MMP-2 and MMP-9 in patients with esophageal cancer were 121.66 ng/ml and 169.73 ng/ml.The levels of MMP-2 and MMP-9 were significantly higher in patients with esophageal cancer than that of general population (t =3.015,P =0.007; t =2.037,P =0.04).The level of MMP-2 was significantly associated with whether or not lymph node metastasis (t =2

  5. Meshat: Monitoring and Experience Sharing Tool for Project-Based Learning

    CERN Document Server

    Michel, Christine

    2009-01-01

    Our work aims at studying tools offered to learners and tutors involved in face-to-face or blended project-based learning activities. To understand better the needs and expectations of each actor, we are especially interested in the specific case of project management training. The results of a course observation show that the lack of monitoring and expertise transfer tools involves important dysfunctions in the course organisation and therefore dissatisfaction for tutors and students (in particular about the acquisition of knowledge and expertise). So as to solve this problem, we propose a personalised platform (according to the actor: project group, student or tutor) which gives information to monitor activities and supports the acquisition and transfer of expertise. This platform is meant for the complex educational context of project-based learning. Indeed, as for the majority of project-based learning activities, the articulation conceptualisation-experiment is an important part of the process. The origi...

  6. Mmp1 processing of the PDF neuropeptide regulates circadian structural plasticity of pacemaker neurons.

    Science.gov (United States)

    Depetris-Chauvin, Ana; Fernández-Gamba, Agata; Gorostiza, E Axel; Herrero, Anastasia; Castaño, Eduardo M; Ceriani, M Fernanda

    2014-10-01

    In the Drosophila brain, the neuropeptide PIGMENT DISPERSING FACTOR (PDF) is expressed in the small and large Lateral ventral neurons (LNvs) and regulates circadian locomotor behavior. Interestingly, PDF immunoreactivity at the dorsal terminals changes across the day as synaptic contacts do as a result of a remarkable remodeling of sLNv projections. Despite the relevance of this phenomenon to circuit plasticity and behavior, the underlying mechanisms remain poorly understood. In this work we provide evidence that PDF along with matrix metalloproteinases (Mmp1 and 2) are key in the control of circadian structural remodeling. Adult-specific downregulation of PDF levels per se hampers circadian axonal remodeling, as it does altering Mmp1 or Mmp2 levels within PDF neurons post-developmentally. However, only Mmp1 affects PDF immunoreactivity at the dorsal terminals and exerts a clear effect on overt behavior. In vitro analysis demonstrated that PDF is hydrolyzed by Mmp1, thereby suggesting that Mmp1 could directly terminate its biological activity. These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior.

  7. Mmp1 processing of the PDF neuropeptide regulates circadian structural plasticity of pacemaker neurons.

    Directory of Open Access Journals (Sweden)

    Ana Depetris-Chauvin

    2014-10-01

    Full Text Available In the Drosophila brain, the neuropeptide PIGMENT DISPERSING FACTOR (PDF is expressed in the small and large Lateral ventral neurons (LNvs and regulates circadian locomotor behavior. Interestingly, PDF immunoreactivity at the dorsal terminals changes across the day as synaptic contacts do as a result of a remarkable remodeling of sLNv projections. Despite the relevance of this phenomenon to circuit plasticity and behavior, the underlying mechanisms remain poorly understood. In this work we provide evidence that PDF along with matrix metalloproteinases (Mmp1 and 2 are key in the control of circadian structural remodeling. Adult-specific downregulation of PDF levels per se hampers circadian axonal remodeling, as it does altering Mmp1 or Mmp2 levels within PDF neurons post-developmentally. However, only Mmp1 affects PDF immunoreactivity at the dorsal terminals and exerts a clear effect on overt behavior. In vitro analysis demonstrated that PDF is hydrolyzed by Mmp1, thereby suggesting that Mmp1 could directly terminate its biological activity. These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior.

  8. CEM ultrasonic flow monitoring design, installation and certification results at the Salt River Project

    Energy Technology Data Exchange (ETDEWEB)

    Rihs, P.W. [Salt River Project, Saint Johns, AZ (United States). Coronado Generating Station

    1995-12-31

    This presentation will include Salt River Project`s design, installation, experiences and results using ultrasonic flow monitoring equipment for certification of continuous emissions monitoring systems. Flow Monitoring is the newest and has been the most controversial component of CEM systems. Experience in measuring flue gas volumetric flow prior to CEMs was very limited. There are currently three basic techniques used to measure gas flow: (1) thermal sensing using hotwire anemometer or thermal dispersion; (2) differential pressure (pitot tube and annubar); (3) acoustic using ultrasonic transducers. The Salt River Project (SRP) operates a variety of affected generating stations: coal, gas and oil. Ultrasonic flow monitoring technology was chosen for all affected generating stations which the author operates. SRP`s approach and reasoning for choosing ultrasonic systems will be discussed. A review of each generating station`s flow monitoring system will be presented. The presentation will include, but may not be limited to, the following: general facilities, description and schematics; physical installations, plan and section drawings; design considerations; results of flow monitors certification testing; and CEMs Project Manager`s conclusions.

  9. Imagerie moleculaire de la MMP-2

    Science.gov (United States)

    Lebel, Rejean

    MMPs (matrix metalloproteinases) are enzymes involved in tissue architecture remodelling and cell migration. MMP-2, particularly, was found to be a biomarker of the progression or prognosis of several pathologies, such as arthritis, atherosclerosis, infarct and cancer. Yet, its exact role in these pathologies is still uncertain. For these reasons, it is critical to develop new tools to enable the specific and non invasive study of MMP-2. As of now, a large number of optical probes (optical imaging), contrast agents (magnetic resonance imaging) and radiotracers (positron emission tomography, single photon emission tomography) have been published in the literature. However, none of the molecules allows for the specific quantification of MMP-2, particularly against MMP-9 which cleaves similar substrates. This thesis describes our progress in the development of new molecules capable of targeting and allowing the imaging of MMP-2. All tested molecules were fond to be quickly activated by MMP-2 and to be selective when compared with MMP3, MMP-7 and MMP-9. First, a contrast agent named PCA2-switch is tested in a mouse subcutaneous tumor model, and allows us to differentiate between tumors with low or high levels of MMP-2 activity. We also developed a panel of activatable fluorescent probes, one of which was found to be highly specific to MMP-2 (low activation by MMP9, efficient quenching). However, an extensive set of control experiments does not enable to conclude on the specificity of the probes in vivo. One of the principal limitations of many studies in the field of MMP imaging is the lack of proper controls, including unspecific uptake controls. The last section of this thesis discusses the impact of the EPR (enhanced permeability and retention) effect on the uptake of a non-specific probe in a subcutaneous tumor model treated with radiotherapy. Proper control experiments that should be performed when testing new MMP-2 probes are discussed. Keywords: Matrix

  10. MMP2 — EDRN Public Portal

    Science.gov (United States)

    MMP2 is a member of the matrix metalloproteinase (MMP) family and is involved in many functions, such as remodeling of the vasculature, angiogenesis, tissue repair and remodeling, tumor invasion, inflammation, atherosclerotic plaque rupture, reproduction and embryonic development, as well as in disease processes such as arthritis and metastasis. In addition to degrading extracellular matrix proteins, MMP2 can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction and appears to have a role in myocardial cell death pathways. MMPs are generally secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The MMP2 protein degrades gelatin type I and collagen types IV, V, VII, and X. MMP2 gene mutations have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. There are two known isoforms of this gene, encoded by two transcript variants.

  11. Project management metrics, KPIs, and dashboards a guide to measuring and monitoring project performance

    CERN Document Server

    Kerzner, Harold

    2017-01-01

    With the growth of complex projects, stakeholder involvement, and advancements in visual-based technology, metrics and KPIs (key performance indicators) are key factors in evaluating project performance. Dashboard reporting systems provide accessible project performance data, and sharing this vital data in a concise and consistent manner is a key communication responsibility of all project managers. This 3rd edition of Kerzner’s groundbreaking work includes the following updates: new sections on processing dashboard information, portfolio management PMO and metrics, and BI tool flexibility. PPT decks by chapter and a test bank will be available for use in seminar presentations and courses.

  12. MMP8, MMP9 AND TIMP1 LEVELS IN GCF AND GINGIVAL TISSUE OF PATIENTS WITH GINGIVAL OVERGROWTH DURING ORTHODONTIC TREATMENT

    Directory of Open Access Journals (Sweden)

    Petra Surlin

    2012-03-01

    Full Text Available Aim. Periodontal remodellng produced during dental orthodontic treatment represents a series of biologicallyactive substances, part of them playing some role in the initiation and propagation of inflammatory processes. The present study aims at demonstrating the MMP8, MMP9 and TIMP1 levels intervening in tissular periodontal remodeling produced during orthodontic treatments, accompanied by gingival overgrowth, as a reaction of the marginal periodontium to mechanical stress. Materials and Method. Selected for the study were 21 patients – 13 females and 8 males – with ages between 13 and 32 years (17.6±1.3 years affected with dento-maxillary anomalies, who received orthodontic treatment with fixed apparatus. Sampling from the gingival fluid was performed 6 times, namely: 1 hour prior to the application of the orthodontic apparatus, 4 hours after its application, again after 8 and 24 hours and then 1 and, respectively, 2 weeks later. If gingival hypertrophy was installed (HTG, the hypertrophic gingiva was removed, and an immuno-histo-chemical examination was made. The patient was weekly monitorized in the first 6 weeks – during the initial orthodontic treatment, then monthly, samples being taken over from the gingival sulcus on each visit made in the first 6 weeks. Results. MMP-9 immuno-marking was positive both at corione level and in the deep structures of the covering epithelium. The positive cells at MMP-9 evidenced different intensities at the level of each structure forming the gingival mucous membrane. In four of the cases under analysis, disorganization of the normal layering/stratification of the epithelium was evidenced, along with the presence of numerous red cells in the chorione of the mucous membrane. In such cases, immuno-marking to MMP8 showed a normal intensity, even if few positive cells, dispersed among the extravasated red cells could be observed. Immunologically, MMP8 and MMP9 obey the same pattern, registering maximum

  13. Handbook to guide the measurement and monitoring of project effectiveness and impact

    Energy Technology Data Exchange (ETDEWEB)

    1986-09-15

    This handbook demonstrates the application of a tool for measuring and monitoring the impact of a development project in the Department of Quezaltenango, Guatemala. That project itself presently is a demonstration. It explores the technical feasibility and the commercial possibilities of direct geothermal heat applications to the processing of agricultural produce - with the eventual purpose of expanding agricultural exports from Guatemala. The handbook focuses on an early stage of the geothermal initiative and guides preparations for future impact measurement and monitoring of geothermal projects. Primarily, guidance is for projects in agricultural applications of geothermal heat - and basically in Quezaltenango. But the exercise and the handbook are relevant in broad outline to other, industrial applications projects as well which may be based in other departments and have immediate impact across the whole country. This handbook attempts to prepare geothermal energy planners in Guatemala for that juncture when geothermal projects can be managed by objectives. It promotes and facilitates thinking about defining specific objectives for projects that result from the demonstration at Zunil (in Quezaltenango Department); and it prompts preparations for obtaining baseline measurements and for making rational projections on the achievements of future projects.

  14. A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP

    DEFF Research Database (Denmark)

    Shiryaev, S A; Remacle, A G; Golubkov, V S;

    2013-01-01

    Matrix metalloproteinases (MMPs) and, especially membrane type 1 (MT1)-MMP/MMP-14, are promising drug targets in malignancies. In contrast with multiple small-molecule and protein pan-inhibitors of MT1-MMP cleavage activity, the murine 9E8 monoclonal antibody targets the MMP-2-activating function...... tissue inhibitor of metalloproteinases-2 (TIMP-2) association with MT1-MMP. As a result, the 9E8 antibody incapacitates the TIMP-2-dependent MMP-2-activating function alone rather than the general enzymatic activity of human MT1-MMP. The specific function of the 9E8 antibody we determined directly...... supports an essential, albeit paradoxical, role of the protein inhibitor (TIMP-2) in MMP-2 activation via a unique membrane-tethered mechanism. In this mechanism, the formation of a tri-molecular MT1-MMPTIMP-2MMP-2 complex is required for both the capture of the soluble MMP-2 proenzyme by cells...

  15. The need for complementary hydraulic analysis in post-restoration monitoring of river restoration projects

    Science.gov (United States)

    Endreny, T. A.; Soulman, M. M.

    2011-03-01

    River restoration design methods are incrementally improved by studying and learning from monitoring data in previous projects. In this paper, we report post-restoration monitoring data for a Natural Channel Design (NCD) restoration project along 1600 m (10 channel wavelengths) of the Batavia Kill in the Catskill Mountains, NY, implemented in 2001 and 2002. The NCD project used a reference-reach to determine channel form, empirical relations between the project site and reference site bankfull dimensions to size channel geometry, and hydraulic and sediment computations to test channel capacity and sediment stability. In addition 12 cross-vanes and 48 j-hook vanes used in NCD for river training were installed to protect against bank erosion and maintain scour pools for fish habitat. Changes in pool depths were monitored with surveys from 2002-2004, and then after the channel-altering April 2005 flood. Aggradation in pools was attributed to cross-vane arms not concentrating flow in the center of the channel, which subsequently caused flow splitting and 4 partial point bar avulsions during the 2005 flood. Hydrodynamic simulation at the 18 m3s-1 bankfull flow suggested avulsions occurred where vanes allowed erosive bank scour to initiate the avulsion cut, and once the flow was split, the diminished in-channel flow caused more aggradation in the pools. In this project post-restoration monitoring had detected aggradation and considered it a problem. The lesson for the larger river restoration community is monitoring protocol should include complementary hydraulic and sediment analysis to comprehend potential consequences and develop preventative maintenance. River restoration and monitoring teams should be trained in robust hydraulic and sediment analytical methods that help them extend project restoration goals.

  16. The need for complementary hydraulic analysis in post-restoration monitoring of river restoration projects

    Directory of Open Access Journals (Sweden)

    T. A. Endreny

    2011-03-01

    Full Text Available River restoration design methods are incrementally improved by studying and learning from monitoring data in previous projects. In this paper, we report post-restoration monitoring data for a Natural Channel Design (NCD restoration project along 1600 m (10 channel wavelengths of the Batavia Kill in the Catskill Mountains, NY, implemented in 2001 and 2002. The NCD project used a reference-reach to determine channel form, empirical relations between the project site and reference site bankfull dimensions to size channel geometry, and hydraulic and sediment computations to test channel capacity and sediment stability. In addition 12 cross-vanes and 48 j-hook vanes used in NCD for river training were installed to protect against bank erosion and maintain scour pools for fish habitat. Changes in pool depths were monitored with surveys from 2002–2004, and then after the channel-altering April 2005 flood. Aggradation in pools was attributed to cross-vane arms not concentrating flow in the center of the channel, which subsequently caused flow splitting and 4 partial point bar avulsions during the 2005 flood. Hydrodynamic simulation at the 18 m3s−1 bankfull flow suggested avulsions occurred where vanes allowed erosive bank scour to initiate the avulsion cut, and once the flow was split, the diminished in-channel flow caused more aggradation in the pools. In this project post-restoration monitoring had detected aggradation and considered it a problem. The lesson for the larger river restoration community is monitoring protocol should include complementary hydraulic and sediment analysis to comprehend potential consequences and develop preventative maintenance. River restoration and monitoring teams should be trained in robust hydraulic and sediment analytical methods that help them extend project restoration goals.

  17. Yakima/Klickitat Fisheries Project Genetic Studies; Yakima/Klickitat Fisheries Project Monitoring and Evaluation, 2005-2006 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Busack, Craig A.; Fritts, Anthony L.; Kassler, Todd (Washington Department of Fish and Wildlife, Olympia, WA)

    2006-05-01

    This report covers one of many topics under the Yakima/Klickitat Fisheries Project's Monitoring and Evaluation Program (YKFPME). The YKFPME is funded under two BPA contracts, one for the Yakama Nation and the other for the Washington Department of Fish and Wildlife (Contract number 22370, Project Number 1995-063-25). A comprehensive summary report for all of the monitoring and evaluation topics will be submitted after all of the topical reports are completed. This approach to reporting enhances the ability of people to get the information they want, enhances timely reporting of results, and provides a condensed synthesis of the whole YKFPME. The current report was completed by the Washington Department of Fish and Wildlife.

  18. Permafrost and Active Layer Monitoring in the Maritime Antarctic: A Contribution to TSP and ANTPAS projects

    Science.gov (United States)

    Vieira, G.; Ramos, M.; Batista, V.; Caselli, A.; Correia, A.; Fragoso, M.; Gruber, S.; Hauck, C.; Kenderova, R.; Lopez-Martinez, J.; Melo, R.; Mendes-Victor, L. A.; Miranda, P.; Mora, C.; Neves, M.; Pimpirev, C.; Rocha, M.; Santos, F.; Blanco, J. J.; Serrano, E.; Trigo, I.; Tome, D.; Trindade, A.

    2008-12-01

    Permafrost and active layer monitoring in the Maritime Antarctic (PERMANTAR) is a Portuguese funded International Project that, in cooperation with the Spanish project PERMAMODEL, will assure the installation and the maintenance of a network of boreholes and active layer monitoring sites, in order to characterize the spatial distribution of the physical and thermal properties of permafrost, as well as the periglacial processes in Livingston and Deception Islands (South Shetlands). The project is part of the International Permafrost Association IPY projects Thermal State of Permafrost (TSP) and Antarctic and Sub-Antarctic Permafrost, Soils and Periglacial Environments (ANTPAS). It contributes to GTN-P and CALM-S networks. The PERMANTAR-PERMAMODEL permafrost and active layer monitoring network includes several boreholes: Reina Sofia hill (since 2000, 1.1m), Incinerador (2000, 2.3m), Ohridski 1 (2008, 5m), Ohridski 2 (2008, 6m), Gulbenkian-Permamodel 1 (2008, 25m) and Gulbenkian- Permamodel 2 (2008, 15m). For active layer monitoring, several CALM-S sites have been installed: Crater Lake (2006), Collado Ramos (2007), Reina Sofia (2007) and Ohridski (2007). The monitoring activities are accompanied by detailed geomorphological mapping in order to identify and map the geomorphic processes related to permafrost or active layer dynamics. Sites will be installed in early 2009 for monitoring rates of geomorphological activity in relation to climate change (e.g. solifluction, rockglaciers, thermokarst). In order to analyse the spatial distribution of permafrost and its ice content, electrical resistivity tomography (ERT), and seismic refraction surveys have been performed and, in early 2009, continuous ERT surveying instrumentation will be installed for monitoring active layer evolution. The paper presents a synthesis of the activities, as well as the results obtained up to the present, mainly relating to ground temperature monitoring and from permafrost characteristics and

  19. Hood River Monitoring and Evaluation Project, Annual Report 2002-2003.

    Energy Technology Data Exchange (ETDEWEB)

    Vaivoda, Alexis

    2004-02-01

    The Hood River Production Program Monitoring and Evaluation Project is co-managed by the Confederated Tribes of Warm Springs (CTWSRO) and the Oregon Department of Fish and Wildlife. The program is divided up to share responsibilities, provide efficiency, and avoid duplication. From October 2002 to September 2003 (FY 03) project strategies were implemented to monitor, protect, and restore anadromous fish and fish habitat in the Hood River subbasin. A description of the progress during FY 03 is reported here. Additionally an independent review of the entire program was completed in 2003. The purpose of the review was to determine if project goals and actions were achieved, look at critical uncertainties for present and future actions, determine cost effectiveness, and choose remedies that would increase program success. There were some immediate changes to the implementation of the project, but the bulk of the recommendations will be realized in coming years.

  20. MONDO Project: real time ocean monitoring through Lagrangian drifters during offshore drilling operations

    Energy Technology Data Exchange (ETDEWEB)

    Mafra, Tatiana [Eni Oil do Brasil, Rio de Janeiro, RJ (Brazil); Fragoso, Mauricio da Rocha; Santos, Francisco Alves dos; Cruz, Leonardo M. Marques A.; Pellegrini, Julio A.C.; Cerrone, Bruna Nogueira [Prooceano, Rio de Janeiro, RJ (Brazil); Assireu, Arcilan Trevenzoli [Instituto Nacional de Pesquisas Espaciais (INPE), Sao Jose dos Campos, SP (Brazil)

    2008-07-01

    Monitoring the ocean conditions during offshore operations is essential for both operational and environmental aspects. Environmentally, not only to know better the environment where the activity is taking place, but also to be able to provide fast and accurate response in case of accidents. MONDO Project (Monitoring by Ocean Drifters) is a pioneer initiative from ENI Oil do Brasil and PROOCEANO that aimed to monitor currents as a part of a metoceanographic data monitoring project of drilling operations in Brazilian Waters, in Santos Basin throughout September to November 2007, 40 satellite tracked ocean drifters were deployed will be transmitting data up to November 2008. The results of this project can be used to study a wide range of subjects about ocean dynamics. Following the principles of social and environmental responsibility, MONDO Project aims to benefit the local ecosystem in increasing the scientific knowledge of the area to calibrate hydrodynamic models that will lead to more accurate modeling results and, as a consequence, to a better management of contingency plans. Based on these principles, the project will also provide unrestricted access to oceanographic data even after the end of operations. (author)

  1. Harvard Observing Project monitoring of Boyajian's Star (KIC 8462852)

    Science.gov (United States)

    Schumer, Clea F.; Vanderburg, Andrew; Bieryla, Allyson; Carmichael, Theron; Garrison, Lehman H.; Huang, Jane; Lewis, John; Mayo, Andrew; Alam, Munazza; Gomez, Sebastian; Kamdar, Harshil; Yuan, Sihan; Cordova, Rodrigo

    2017-01-01

    Between 2009 and 2013, the Kepler spacecraft observed ~200,000 stars, repeatedly measuring their brightness to look for regular dimmings that could indicate the presence of a transiting planet (Borucki et al. 2010). This endeavor led to the discovery of thousands of planets. However, the data pertaining to one star, KIC 8462852, nicknamed “Tabby's Star” or “Boyajian's Star" indicated sporadic dimmings thought to be resulting from massive, evolving, and erratic shapes passing in front of the star (Boyajian et al. 2016, Wright and Sigurdsson 2016). Additional observations have indicated that KIC 8462852 has faded by approximately 20% over the past century (Wright and Sigurdsson 2016). Kepler is now observing other areas of space, and consequently, ground-based efforts have emerged in order to continue tracking the brightness of KIC 8462852. The Harvard Observing Project (HOP) is an observational astronomy initiative that engages undergraduate students and provides graduate students with the opportunity to lead sessions of data collection. During the fall 2016 semester, HOP will be observing KIC 8462852 in BVRI filters using Harvard's 16-inch DFM Clay telescope. We will present a light curve of the star spanning the course of three months.

  2. Characterization, Monitoring, and Risk Assessment at the IEA GHG Weyburn-Midale CO2 Monitoring and Storage Project, Saskatchewan, Canada.

    Science.gov (United States)

    Ben, R.; Chalaturnyk, R.; Gardner, C.; Hawkes, C.; Johnson, J.; White, D.; Whittaker, S.

    2008-12-01

    In July 2000, a major research project was initiated to study the geological storage of CO2 as part of a 5000 tonnes/day EOR project planned for the Weyburn Field in Saskatchewan, Canada. Major objectives of the IEA GHG Weyburn CO2 monitoring and storage project included: assessing the integrity of the geosphere encompassing the Weyburn oil pool for effective long-term storage of CO2; monitoring the movement of the injected CO2, and assessing the risk of migration of CO2 from the injection zone (approximately 1500 metres depth) to the surface. Over the period 2000-2004, a diverse group of 80+ researchers worked on: geological, geophysical, and hydrogeological characterizations at both the regional (100 km beyond the field) and detailed scale (10 km around the field); conducted time-lapse geophysical surveys; carried out surface and subsurface geochemical surveys; and undertook numerical reservoir simulations. Results of the characterization were used for a performance assessment that concluded the risk of CO2 movement to the biosphere was very small. By September 2007, more than 14 Mtonnes of CO2 had been injected into the Weyburn reservoir, including approximately 3 Mtonnes recycled from oil production. A "Final Phase" research project was initiated (2007- 2011) to contribute to a "Best Practices" guide for long-term CO2 storage in EOR settings. Research objectives include: improving the geoscience characterization; further detailed analysis and data collection on the role of wellbores; additional geochemical and geophysical monitoring activities; and an emphasis on quantitative risk assessments using multiple analysis techniques. In this talk a review of results from Phase I will be presented followed by plans and initial results for the Final Phase.

  3. Matrix metalloproteinase-2 (MMP-2) and MMP-9 expression in invasive ductal carcinoma of the breast.

    Science.gov (United States)

    Sullu, Yurdanur; Demirag, Guzin G; Yildirim, Arzu; Karagoz, Filiz; Kandemir, Bedri

    2011-12-15

    Matrix metalloproteinase-2 (MMP-2) and MMP-9 are gelatinases that play a role in the invasion and metastasis of cancer through the destruction of the basal membrane and extracellular matrix. In this study, we investigated the immunohistochemical expression of MMP-2 and MMP-9 and the correlation between the expression levels and prognostic clinicopathological parameters in 140 patients with invasive ductal carcinoma (IDC). The staining scores for MMP-9 were negative in 21 cases (15%), mild in 27 cases (19%), and strong in 92 cases (66%). MMP-9 expression was increased in high-grade (p=0.001), triple-negative (ER, PR, HER2 negative) (p=0.006), and ER-negative tumors (p=0.004) and tumors with distant metastases (p=0.028). MMP-9 expression was increased in cases with HER2 over-expression/amplification, but no statistically significant difference was found (p=0.215). No correlation was found between lymph node metastasis or tumor size and MMP-9 expression (p=0.492 and p=0.448, respectively). The staining scores for MMP-2 in 140 cases were negative in 10 cases (7%), mild in 25 cases (18%), and strong in 105 cases (75%). MMP-2 expression was increased in ER-negative and high-grade tumors in the lymph node-negative group (p=0.025 and 0.026, respectively). High MMP-9 expression was associated with a shorter disease-free survival and overall survival times (p=0.042 and p=0.046, respectively). In conclusion, increased MMP-9 expression is related to poor prognostic clinicopathological factors in IDC, and hence, it can be utilized as a supplementary prognostic marker. The role of MMP-2 expression in the prognosis of IDC is rather limited.

  4. Multimode Process Monitoring Based on Fuzzy C-means in Locality Preserving Projection Subspace

    Institute of Scientific and Technical Information of China (English)

    解翔; 侍洪波

    2012-01-01

    For complex industrial processes with multiple operational conditions, it is important to develop effective monitoring algorithms to ensure the safety of production processes. This paper proposes a novel monitoring strategy based on fuzzy C-means. The high dimensional historical data are transferred to a low dimensional subspace spanned by locality preserving projection. Then the scores in the novel subspace are classified into several overlapped clusters, each representing an operational mode. The distance statistics of each cluster are integrated though the membership values into a novel BID (Bayesian inference distance) monitoring index. The efficiency and effectiveness of the proposed method are validated though the Tennessee Eastman benchmark process.

  5. MMP10 — EDRN Public Portal

    Science.gov (United States)

    From NCBI Gene: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008

  6. International Energy Agency (IEA) Greenhouse Gas (GHG) Weyburn-Midale CO₂ Monitoring and Storage Project

    Energy Technology Data Exchange (ETDEWEB)

    Sacuta, Norm [Petroleum Technology Research Centre Incorporated, Saskatchewan (Canada); Young, Aleana [Petroleum Technology Research Centre Incorporated, Saskatchewan (Canada); Worth, Kyle [Petroleum Technology Research Centre Incorporated, Saskatchewan (Canada)

    2015-12-22

    The IEAGHG Weyburn-Midale CO₂ Monitoring and Storage Project (WMP) began in 2000 with the first four years of research that confirmed the suitability of the containment complex of the Weyburn oil field in southeastern Saskatchewan as a storage location for CO₂ injected as part of enhanced oil recovery (EOR) operations. The first half of this report covers research conducted from 2010 to 2012, under the funding of the United States Department of Energy (contract DEFE0002697), the Government of Canada, and various other governmental and industry sponsors. The work includes more in-depth analysis of various components of a measurement, monitoring and verification (MMV) program through investigation of data on site characterization and geological integrity, wellbore integrity, storage monitoring (geophysical and geochemical), and performance/risk assessment. These results then led to the development of a Best Practices Manual (BPM) providing oilfield and project operators with guidance on CO₂ storage and CO₂-EOR. In 2013, the USDOE and Government of Saskatchewan exercised an optional phase of the same project to further develop and deploy applied research tools, technologies, and methodologies to the data and research at Weyburn with the aim of assisting regulators and operators in transitioning CO₂-EOR operations into permanent storage. This work, detailed in the second half of this report, involves seven targeted research projects – evaluating the minimum dataset for confirming secure storage; additional overburden monitoring; passive seismic monitoring; history-matched modelling; developing proper wellbore design; casing corrosion evaluation; and assessment of post CO₂-injected core samples. The results from the final and optional phases of the Weyburn-Midale Project confirm the suitability of CO₂-EOR fields for the injection of CO₂, and further, highlight the necessary MMV and follow-up monitoring required for these operations to be considered

  7. Expression and inhibition of matrix metalloproteinase (MMP)-8, MMP-9 and MMP-12 in early colonic anastomotic repair

    DEFF Research Database (Denmark)

    Krarup, Peter-Martin; Eld, Mikkel; Heinemeier, Katja Maria;

    2013-01-01

    Submucosal collagen is paramount for colonic anastomotic integrity. Matrix metalloproteinases (MMPs) mediate collagen degradation that increases the risk of wound dehiscence. Although broad-spectrum MMP inhibitors are beneficial for anastomotic strength, they can cause adverse reactions. Knowledg...

  8. Monitoring and Evaluating Projects : A Step-by-Step Primer on Monitoring, Benchmarking, and Impact Evaluation

    OpenAIRE

    Rebekka E. Grun

    2006-01-01

    This paper attempts to be a practical step-by-step guide to prepare and carry out benchmarking and impact analyses of projects. It's purpose is to attempt to present analytical tools solidly grounded in economic theory all while focusing on the practical questions of evaluations. Little space is given to theory, in order to spend more time on the actual steps involved, trying to make this ...

  9. Skin wound healing in MMP2-deficient and MMP2 / plasminogen double-deficient mice

    DEFF Research Database (Denmark)

    Frøssing, Signe; Rønø, Birgitte; Hald, Andreas;

    2010-01-01

    -sensitive MMPs during wound healing. To address whether MMP2 is accountable for the galardin-induced healing deficiency in wildtype and Plg-deficient mice, incisional skin wounds were generated in MMP2 single-deficient mice and in MMP2/Plg double-deficient mice and followed until healed. Alternatively, tissue...... was isolated 7 days post wounding for histological and biochemical analyses. No difference was found in the time from wounding to overt gross restoration of the epidermal surface between MMP2-deficient and wildtype control littermate mice. MMP2/Plg double-deficient mice were viable and fertile, and displayed...... an unchallenged general phenotype resembling that of Plg-deficient mice, including development of rectal prolapses. MMP2/Plg double-deficient mice displayed a slight increase in the wound length throughout the healing period compared with Plg-deficient mice. However, the overall time to complete healing...

  10. The Umatilla Basin Natural Production Monitoring and Evaluation Project, 2008 Annual Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Contor, Craig R.; Harris, Robin; King, Marty [Confederated Tribes of the Umatilla Indian Reservation

    2009-06-10

    The Umatilla Basin Natural Production Monitoring and Evaluation Project (UBNPMEP) is funded by Bonneville Power Administration (BPA) as directed by section 4(h) of the Pacific Northwest Electric Power Planning and Conservation Act of 1980 (P.L.96-501). This project is in accordance with and pursuant to measures 4.2A, 4.3C.1, 7.1A.2, 7.1C.3, 7.1C.4 and 7.1D.2 of the Northwest Power Planning Council's (NPPC) Columbia River Basin Fish and Wildlife Program (NPPC 1994). Work was conducted by the Fisheries Program of the Confederated Tribes of the Umatilla Indian Reservation (CTUIR). The UBNPMEP is coordinated with two Oregon Department of Fish and Wildlife (ODFW) research projects that also monitor and evaluate the success of the Umatilla Fisheries Restoration Plan. This project deals with the natural production component of the plan, and the ODFW projects evaluate hatchery operations (project No. 1990-005-00, Umatilla Hatchery M & E) and smolt outmigration (project No. 1989-024-01, Evaluation of Juvenile Salmonid Outmigration and Survival in the Lower Umatilla River). Collectively these three projects monitor and evaluate natural and hatchery salmonid production in the Umatilla River Basin. The need for natural production monitoring has been identified in multiple planning documents including Wy-Kan-Ush-Mi Wa-Kish-Wit Volume I, 5b-13 (CRITFC 1996), the Umatilla Hatchery Master Plan (CTUIR & ODFW 1990), the Umatilla Basin Annual Operation Plan, the Umatilla Subbasin Summary (CTUIR & ODFW 2001), the Subbasin Plan (CTUIR & ODFW 2004), and the Comprehensive Research, Monitoring, and Evaluation Plan (CTUIR and ODFW 2006). Natural production monitoring and evaluation is also consistent with Section III, Basinwide Provisions, Strategy 9 of the 2000 Columbia River Basin Fish and Wildlife Program (NPPC 1994, NPCC 2004). The Umatilla Basin M&E plan developed along with efforts to restore natural populations of spring and fall Chinook salmon, (Oncorhynchus tshawytsha), coho

  11. Protocols for Monitoring Habitat Restoration Projects in the Lower Columbia River and Estuary

    Energy Technology Data Exchange (ETDEWEB)

    Roegner, G. Curtis; Diefenderfer, Heida L.; Borde, Amy B.; Thom, Ronald M.; Dawley, Earl M.; Whiting, Allan H.; Zimmerman, Shon A.; Johnson, Gary E.

    2008-04-25

    Protocols for monitoring salmon habitat restoration projects are essential for the U.S. Army Corps of Engineers' environmental efforts in the Columbia River estuary. This manual provides state-of-the science data collection and analysis methods for landscape features, water quality, and fish species composition, among others.

  12. Preliminary evaluation of a prototype welfare monitoring system for sows and piglets (Welfare Quality (R) project)

    NARCIS (Netherlands)

    Scott, K.; Binnendijk, G.P.; Edwards, S.A.; Gu, J.H.; Wijhe-Kiezebrink, van M.C.; Vermeer, H.M.

    2009-01-01

    The Welfare Quality(R) project aims to develop a European on-form welfare assessment standard for pigs, amongst other species. A prototype monitoring system was developed for sows and piglets using predominantly animal-based measures of behaviour, health and physiology to assess welfare. The

  13. Modeling radiation conditions in orbits of projected system of small satellites for radiation monitoring

    Science.gov (United States)

    Panasyuk, M. I.; Podzolko, M. V.; Kovtyukh, A. S.; Osedlo, V. I.; Tulupov, V. I.; Yashin, I. V.

    2016-11-01

    Calculated estimates are presented for the accumulated radiation doses behind the shields of various thicknesses in the orbits of projected at Skobeltsyn Institute of Nuclear Physics, Moscow State University system of small satellites for radiation monitoring. The results are analyzed and compared with the calculation data for other actively exploited near-Earth orbits.

  14. Outcome mapping as methodology to monitor and evaluate community informatics projects: A case study

    CSIR Research Space (South Africa)

    Herselman, M

    2010-10-01

    Full Text Available The purpose of this paper is to indicate how Outcome Mapping (OM) can be used as a methodology to monitor and evaluate a specific developmental informatics project currently under way in the Meraka Institute. OM was applied in the Broadband for All...

  15. Preliminary evaluation of a prototype welfare monitoring system for sows and piglets (Welfare Quality (R) project)

    NARCIS (Netherlands)

    Scott, K.; Binnendijk, G.P.; Edwards, S.A.; Gu, J.H.; Wijhe-Kiezebrink, van M.C.; Vermeer, H.M.

    2009-01-01

    The Welfare Quality(R) project aims to develop a European on-form welfare assessment standard for pigs, amongst other species. A prototype monitoring system was developed for sows and piglets using predominantly animal-based measures of behaviour, health and physiology to assess welfare. The prototy

  16. Integrating a project monitoring system into a public health network: experiences from Alive & Thrive Vietnam.

    Science.gov (United States)

    Tuan, Nguyen Thanh; Alayon, Silvia; Do, Tran Thanh; Ngan, Tran Thi; Hajeebhoy, Nemat

    2015-01-01

    Little information is available about how to build a monitoring system to measure the output of preventive nutrition interventions, such as counselling on infant and young child feeding. This paper describes the Alive & Thrive Vietnam (A&T) project experience in nesting a large-scale project monitoring system into the existing public health information system (e.g. using the system and resources), and in using monitoring data to strengthen service delivery in 15 provinces with A&T franchises. From January 2012 to April 2014, the 780 A&T franchises provided 1,700,000 counselling contacts (~3/4 by commune franchises). In commune franchises in April 2014, 80% of mothers who were pregnant or with children under two years old had been to the counselling service at least one time, and 87% of clients had been to the service earlier. Monitoring data are used to track the progress of the project, make decisions, provide background for a costing study and advocate for the integration of nutrition counselling indicators into the health information system nationwide. With careful attention to the needs of stakeholders at multiple levels, clear data quality assurance measures and strategic feedback mechanisms, it is feasible to monitor the scale-up of nutrition programmes through the existing routine health information system.

  17. MMP7 — EDRN Public Portal

    Science.gov (United States)

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

  18. Functional Promoter Polymorphisms of MMP-2 C-735T and MMP-9 C-1562T and Their Synergism with MMP-7 A-181G in Multiple Sclerosis.

    Science.gov (United States)

    Rahimi, Zohreh; Abdan, Zahra; Rahimi, Ziba; Razazian, Nazanin; Shiri, Hadis; Vaisi-Raygani, Asad; Shakiba, Ebrahim; Vessal, Mahmood; Moradi, Mohammad-Taher

    2016-08-01

    Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. Matrix metalloproteinases (MMPs) play an important role in breakdown of blood-brain barrier, transmigration, and invasion of immune cells and formation of MS lesions. The aim of present study was to investigate the influence of MMP-2 C-735T and MMP-9 C-1562T variants and their synergism with MMP-7 A-181G on susceptibility to MS. In a case-control study 125 MS patients and 235 healthy individuals from Western Iran were investigated. The various genotypes of MMP-2, MMP-9, and MMP-7 were detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In females the presence of MMP-2 C allele was associated with an increased risk of MS (OR = 1.69, p = 0.041). No significant difference was detected between the frequency of MMP-9 T allele in MS patients (8.2%) and controls (12.8%, p = 0.068). The concomitant presence of both MMP-2 C and MMP-7 G alleles was associated with 1.82-fold increased risk of MS (p = 0.002). Also, a synergism was detected between MMP-9 C and MMP-7 G alleles that elevated the risk of MS by 1.5-times (p = 0.035). The presence of haplotype MMP-9 T, MMP-7 G, and MMP-2 C (TGC) compared to haplotype CAG increased the risk of MS by 3.13-fold (p = 0.16). The present study suggests that gene-gene interactions and variants of more genes instead of single gene might play a role in susceptibility to MS. We indicated that synergism between variants of MMP-2, MMP-7, and MMP-9 genes might increase the risk of MS.

  19. Characterization of quenched fluorescent triple helical peptides for MMP-2 and MMP-9 optical imaging

    Science.gov (United States)

    Cheney, Philip P.; Fields, Gregg B.; Achilefu, Samuel; Edwards, W. Barry

    2009-02-01

    The prevalence of the gelatinases, MMP-2 and MMP-9, in many human tumors, including breast, colorectal, prostate and gastric cancer, make them an attractive target for molecular imaging. A self assembling homotrimeric triple helical peptide (THP), incorporating sequences from type V collagen with high specificity to MMP-2 and MMP-9, was previously developed. To investigate the viability of a THP for gelatinase imaging, we conjugated 5FAM to ..-amino groups of lysine flanking the hydrolysis site and subjected this substrate (THP-5FAM) to vitro analysis. The synthesis and in vitro results was presented.

  20. MMP-2 and MMP-9 as prognostic factors in ischaemic stroke

    Directory of Open Access Journals (Sweden)

    Justyna Zielińska-Turek

    2016-09-01

    Full Text Available Objectives: No widely available, adequately sensitive diagnostic test to establish prognosis in stroke patients has been developed thus far. The aim of this study was to analyse changes in plasma levels of MMP-9 and MMP-2 as potential prognostic factors in patients with ischaemic stroke. Methods: The study included 56 patients presenting with the signs of ischaemic stroke for less than 24 hours, and 60 healthy controls without a history of neurological and/or inflammatory disorders. Plasma concentrations of MMP-2 and MMP-9 were determined immunoenzymatically at admission (i.e. within 24 hours of the cerebrovascular episode and on the 7th day of hospital stay. Results: Median concentrations of MMP-9 in stroke patients were significantly lower than in the controls, both at admission and on the 7th day of hospital stay. No significant changes in the concentration of MMP-2 in ischaemic stroke patients were observed during the course of hospital stay. No significant association was found between both MMP concentrations and neurological status of patients with cerebrovascular episodes. Conclusions: The lack of significant associations between plasma concentrations of MMP-2/MMP-9 and clinical status suggests that these metalloproteinases should not be used as prognostic factors in patients with ischaemic cerebral episodes.

  1. Change of MMP dependent on temperature

    DEFF Research Database (Denmark)

    Rudyk, Svetlana Nikolayevna; Søgaard, Erik Gydesen; Akwansa, Eugene

    2008-01-01

    substantially depend on temperature, - at  temperature 50oC the distance between A and B is longer, - at temperature 70oC the A-B part of curve is smooth and scarcely seen.      The observations made are important for determination of MMP. If point A is taken as MMP instead of point B, it is a big...

  2. Overview of vegetation monitoring data, 1952--1983. Hanford Environmental Dose Reconstruction Project

    Energy Technology Data Exchange (ETDEWEB)

    Duncan, J.P.

    1994-03-01

    This report is a result of the Hanford Environmental Dose Reconstruction (HEDR) Project. The goal of the HEDR Project is to estimate the radiation dose that individuals could have received from emissions since 1944 at the Hanford Site near Richland, Washington. Members of the HEDR Project`s Environmental Monitoring Data Task have developed databases of historical environmental measurements of such emissions. The HEDR Project is conducted by Battelle, Pacific Northwest Laboratories. This report is the third in a series that documents the information available on measurements of iodine-131 concentrations in vegetation. The first two reports provide the data for 1945--1951. This report provides an overview of the historical documents, which contain vegetation data for 1952--1983. The overview is organized according to the documents available for any given year. Each section, covering one year, contains a discussion of the media sampled, the sampling locations, significant events if there were any, emission quantities, constituents measured, and a list of the documents with complete reference information. Because the emissions which affected vegetation were significantly less after 1951, the vegetation monitoring data after that date have not been used in the HEDR Project. However, access to these data may be of interest to the public. This overview is, therefore, being published.

  3. Nearshore and offshore environmental effects monitoring at the Sable Offshore Energy project

    Energy Technology Data Exchange (ETDEWEB)

    Hurley, G. V. [Sable Offshore Energy Inc, Halifax, NS (Canada)

    2000-07-01

    A monitoring program to determine whether any temporary or permanent environmental perturbations may be attributable to the Sable offshore gas pipeline project as it approaches landfall at Goldboro through an outer bay is discussed, This nearshore region is an active fishing region for the residents of Goldboro, hence the concern about possible contamination. The monitoring project began with a baseline study, followed by monitoring the construction and the recovery period following construction, to ensure that any persistent changes to the nearshore aquatic environment were documented. The monitoring study included representatives of the fishing community to ensure that concerns are addressed early and on a continuing basis. At various phases of the project water properties,sediment modelling, the effects of construction on sea bottom conditions, benthic biota and cultivated mussels, water quality, phytoplankton, and resuspension of toxic cysts, terns and other seabirds were studied. Monitoring programs were also established for sea urchins and mussels, two important commercial species. Commercial-sized sea urchins showed a decrease of 60 per cent between 1998 and 1999 (i.e. the construction period). Recovery of sea urchin population in the immediate trench region will be the special focus of the post-construction monitoring phase. Mussel spat settlement and mussel tissue condition, lobster trapping, water properties, and bird behaviour showed no measurable changes during construction monitoring. In addition to these studies there is an ongoing offshore monitoring program in effect by Sable Offshore Energy Inc., put in place as a condition of approval of its Development Plan by the Canada-Nova Scotia Offshore Petroleum Board. This program monitors attributes such as water quality, suspended particulate matter in the benthic boundary layer, sediment quality, the benthic habitat and megafaunal community, shellfish body burden and taint, marine mammals and seabirds

  4. The expressions of MMP-2,MMP-7,MMP-9 and EMMPRIN in human colorectal carcinoma and its significance%结、直肠癌中MMP-2、MMP-7、MMP-9与EMMPRIN 的表达及意义

    Institute of Scientific and Technical Information of China (English)

    凌林; 胡郁之; 孙礼侠; 刘昌阔; 刘志刚

    2015-01-01

    目的::探讨基质金属蛋白酶( MMP)-2、MMP-7、MMP-9和基质金属蛋白酶诱导因子( EMMPRIN)在结、直肠癌中的表达以及在结、直肠癌发展过程中的作用。方法:采用免疫组织化学法检测100例结、直肠癌组织中MMP-2、MMP-7、MMP-9和EMMPRIN的表达。结果:MMP-2、MMP-7、MMP-9和EMMPRIN在结、直肠癌组织中的表达在结、直肠癌的浸润深度、Dukes分期和有无淋巴结转移间差异均有统计学意义(P<0.01);EMMPRIN分别与MMP-2、MMP-7、MMP-9蛋白在结、直肠癌组织中的表达呈正相关关系(P<0.01)。结论:MMP-2、MMP-7、MMP-9和EMMPRIN在结、直肠癌的演进过程中可能具有一定的协同作用。%Objective:To investigate the expressions of matrix metalloproteinases-2,7 and 9(MMP-2,MMP-7 and MMP-9) and extracellular matrix metalloproteinase inducer ( EMMPRIN ) and their roles in the development process of colorectal carcinoma. Methods:The protein expressions of MMP-2,MMP-7,MMP-9 and EMMPRIN in 100 colorectal carcinoma tissue samples were detected by immunohistochemical method. Results:The differences of the expressions rates of MMP-2, MMP-7, MMP-9 and EMMPRIN in colorectal carcinoma tissue samples with different invasion depth,Dukes stage and lymph node metastasis were statistically significant (P<0. 05). The expressions between EMMPRIN and MMP-2,MMP-7 and MMP-9 in colorectal carcinoma tissue were significant positive correlation,respectively(P<0. 01). Conclusions:The expressions of MMP-2,MMP-7,MMP-9 and EMMPRIN have synergetic effects in the development of colorectal carcinoma.

  5. Annual report for RCRA groundwater monitoring projects at Hanford Site facilities for 1993

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-01

    This report presents the annual hydrogeologic evaluation of 20 Resource Conservation and Recovery Act of 1976 groundwater monitoring projects and 1 nonhazardous waste facility at the US Department of Energy`s Hanford Site. Most of the projects no longer receive dangerous waste; a few projects continue to receive dangerous waste constituents for treatment, storage, or disposal. The 20 RCRA projects comprise 30 waste management units. Ten of the units are monitored under groundwater quality assessment status because of elevated levels of indicator parameters. The impact of those units on groundwater quality, if any, is being investigated. If dangerous waste or waste constituents have entered groundwater, their concentration, distribution, and rate of migration are evaluated. Groundwater is monitored at the other 20 units to detect contamination, should it occur. This report provides an interpretation of groundwater data collected at the waste management units between October 1992 and September 1993. Recent groundwater quality is also described for the 100, 200, 300, and 600 Areas and for the entire Hanford Site. Widespread contaminants include nitrate, chromium, carbon tetrachloride, tritium, and other radionuclides.

  6. Transport infrastructure surveillance and monitoring by electromagnetic sensing: the ISTIMES project.

    Science.gov (United States)

    Proto, Monica; Bavusi, Massimo; Bernini, Romeo; Bigagli, Lorenzo; Bost, Marie; Bourquin, Frédrèric; Cottineau, Louis-Marie; Cuomo, Vincenzo; Della Vecchia, Pietro; Dolce, Mauro; Dumoulin, Jean; Eppelbaum, Lev; Fornaro, Gianfranco; Gustafsson, Mats; Hugenschmidt, Johannes; Kaspersen, Peter; Kim, Hyunwook; Lapenna, Vincenzo; Leggio, Mario; Loperte, Antonio; Mazzetti, Paolo; Moroni, Claudio; Nativi, Stefano; Nordebo, Sven; Pacini, Fabrizio; Palombo, Angelo; Pascucci, Simone; Perrone, Angela; Pignatti, Stefano; Ponzo, Felice Carlo; Rizzo, Enzo; Soldovieri, Francesco; Taillade, Fédrèric

    2010-01-01

    The ISTIMES project, funded by the European Commission in the frame of a joint Call "ICT and Security" of the Seventh Framework Programme, is presented and preliminary research results are discussed. The main objective of the ISTIMES project is to design, assess and promote an Information and Communication Technologies (ICT)-based system, exploiting distributed and local sensors, for non-destructive electromagnetic monitoring of critical transport infrastructures. The integration of electromagnetic technologies with new ICT information and telecommunications systems enables remotely controlled monitoring and surveillance and real time data imaging of the critical transport infrastructures. The project exploits different non-invasive imaging technologies based on electromagnetic sensing (optic fiber sensors, Synthetic Aperture Radar satellite platform based, hyperspectral spectroscopy, Infrared thermography, Ground Penetrating Radar-, low-frequency geophysical techniques, Ground based systems for displacement monitoring). In this paper, we show the preliminary results arising from the GPR and infrared thermographic measurements carried out on the Musmeci bridge in Potenza, located in a highly seismic area of the Apennine chain (Southern Italy) and representing one of the test beds of the project.

  7. Transport Infrastructure Surveillance and Monitoring by Electromagnetic Sensing: The ISTIMES Project

    Directory of Open Access Journals (Sweden)

    Marie Bost

    2010-11-01

    Full Text Available The ISTIMES project, funded by the European Commission in the frame of a joint Call “ICT and Security” of the Seventh Framework Programme, is presented and preliminary research results are discussed. The main objective of the ISTIMES project is to design, assess and promote an Information and Communication Technologies (ICT-based system, exploiting distributed and local sensors, for non-destructive electromagnetic monitoring of critical transport infrastructures. The integration of electromagnetic technologies with new ICT information and telecommunications systems enables remotely controlled monitoring and surveillance and real time data imaging of the critical transport infrastructures. The project exploits different non-invasive imaging technologies based on electromagnetic sensing (optic fiber sensors, Synthetic Aperture Radar satellite platform based, hyperspectral spectroscopy, Infrared thermography, Ground Penetrating Radar-, low-frequency geophysical techniques, Ground based systems for displacement monitoring. In this paper, we show the preliminary results arising from the GPR and infrared thermographic measurements carried out on the Musmeci bridge in Potenza, located in a highly seismic area of the Apennine chain (Southern Italy and representing one of the test beds of the project.

  8. Project monitoring and evaluation: an enhancing method for health research system management.

    Science.gov (United States)

    Djalalinia, Shirin; Owlia, Parviz; Malekafzali, Hossein; Ghanei, Mostafa; Babamahmoodi, Abdolreza; Peykari, Niloofar

    2014-04-01

    Planning, organizing, staffing, leading and monitoring are the basic functional component of management. In present article, we aim to define the project monitoring and evaluation in health research system (HRS) considering its success and challenges based on our national experience. IN THIS STUDY BASED ON THE INFORMATION OF ANNUAL MEDICAL SCIENCE UNIVERSITIES EVALUATION DURING THE LAST DECADE THE HRS INDICATORS HAVE BEEN SCORED IN THREE AXES BASED ON HRS FUNCTIONS: Stewardship, capacity building and knowledge production. In this article, we will focus on the results of HRS evaluation from 2002 to 2010, also on its success and challenges. In an overall view, the main results are the experiences of the designing and implantation of such process after pre-project preparation, all parts followed under the whole supervision of the aims of the HRS evaluation. Project management light the way of practical application of knowledge, skills, tools and techniques for better HRS evaluation and management. We concluded that; although monitoring and evaluation as an essential part of HRS Management light the improvement ahead way but we still need to advantage of the new project management advances.

  9. Applicability of the "Frame of Reference" approach for environmental monitoring of offshore renewable energy projects.

    Science.gov (United States)

    Garel, Erwan; Rey, Cibran Camba; Ferreira, Oscar; van Koningsveld, Mark

    2014-08-01

    This paper assesses the applicability of the Frame of Reference (FoR) approach for the environmental monitoring of large-scale offshore Marine Renewable Energy (MRE) projects. The focus is on projects harvesting energy from winds, waves and currents. Environmental concerns induced by MRE projects are reported based on a classification scheme identifying stressors, receptors, effects and impacts. Although the potential effects of stressors on most receptors are identified, there are large knowledge gaps regarding the corresponding (positive and negative) impacts. In that context, the development of offshore MRE requires the implementation of fit-for-purpose monitoring activities aimed at environmental protection and knowledge development. Taking European legislation as an example, it is suggested to adopt standardized monitoring protocols for the enhanced usage and utility of environmental indicators. Towards this objective, the use of the FoR approach is advocated since it provides guidance for the definition and use of coherent set of environmental state indicators. After a description of this framework, various examples of applications are provided considering a virtual MRE project located in European waters. Finally, some conclusions and recommendations are provided for the successful implementation of the FoR approach and for future studies.

  10. Collaborative Systemwide Monitoring and Evaluation Project (CSMEP) - Year 5 : Annual Report for FY 2008.

    Energy Technology Data Exchange (ETDEWEB)

    Marmorek, David R.; Porter, Marc; Pickard, Darcy; Wieckowski, Katherine

    2008-11-19

    The Collaborative Systemwide Monitoring and Evaluation Project (CSMEP) is a coordinated effort to improve the quality, consistency, and focus of fish population and habitat data to answer key monitoring and evaluation questions relevant to major decisions in the Columbia River Basin. CSMEP was initiated by the Columbia Basin Fish and Wildlife Authority (CBFWA) in October 2003. The project is funded by the Bonneville Power Administration (BPA) through the Northwest Power and Conservation Council's Fish and Wildlife Program (NPCC). CSMEP is a major effort of the federal state and Tribal fish and wildlife managers to develop regionally integrated monitoring and evaluation (M&E) across the Columbia River Basin. CSMEP has focused its work on five monitoring domains: status and trends monitoring of populations and action effectiveness monitoring of habitat, harvest, hatcheries, and the hydrosystem. CSMEP's specific goals are to: (1) interact with federal, state and tribal programmatic and technical entities responsible for M&E of fish and wildlife, to ensure that work plans developed and executed under this project are well integrated with ongoing work by these entities; (2) document, integrate, and make available existing monitoring data on listed salmon, steelhead, bull trout and other fish species of concern; (3) critically assess strengths and weaknesses of these data for answering key monitoring questions; and (4) collaboratively design, implement and evaluate improved M&E methods with other programmatic entities in the Pacific Northwest. During FY2008 CSMEP biologists continued their reviews of the strengths and weaknesses (S&W) of existing subbasin inventory data for addressing monitoring questions about population status and trends at different spatial and temporal scales. Work was focused on Lower Columbia Chinook and steelhead, Snake River fall Chinook, Upper Columbia Spring Chinook and steelhead, and Middle Columbia River Chinook and steelhead. These

  11. Collaborative Systemwide Monitoring and Evaluation Project (CSMEP) - Year 5 : Annual Report for FY 2008.

    Energy Technology Data Exchange (ETDEWEB)

    Marmorek, David R.; Porter, Marc; Pickard, Darcy; Wieckowski, Katherine

    2008-11-19

    The Collaborative Systemwide Monitoring and Evaluation Project (CSMEP) is a coordinated effort to improve the quality, consistency, and focus of fish population and habitat data to answer key monitoring and evaluation questions relevant to major decisions in the Columbia River Basin. CSMEP was initiated by the Columbia Basin Fish and Wildlife Authority (CBFWA) in October 2003. The project is funded by the Bonneville Power Administration (BPA) through the Northwest Power and Conservation Council's Fish and Wildlife Program (NPCC). CSMEP is a major effort of the federal state and Tribal fish and wildlife managers to develop regionally integrated monitoring and evaluation (M&E) across the Columbia River Basin. CSMEP has focused its work on five monitoring domains: status and trends monitoring of populations and action effectiveness monitoring of habitat, harvest, hatcheries, and the hydrosystem. CSMEP's specific goals are to: (1) interact with federal, state and tribal programmatic and technical entities responsible for M&E of fish and wildlife, to ensure that work plans developed and executed under this project are well integrated with ongoing work by these entities; (2) document, integrate, and make available existing monitoring data on listed salmon, steelhead, bull trout and other fish species of concern; (3) critically assess strengths and weaknesses of these data for answering key monitoring questions; and (4) collaboratively design, implement and evaluate improved M&E methods with other programmatic entities in the Pacific Northwest. During FY2008 CSMEP biologists continued their reviews of the strengths and weaknesses (S&W) of existing subbasin inventory data for addressing monitoring questions about population status and trends at different spatial and temporal scales. Work was focused on Lower Columbia Chinook and steelhead, Snake River fall Chinook, Upper Columbia Spring Chinook and steelhead, and Middle Columbia River Chinook and steelhead. These

  12. 骨肉瘤组织中MMP-2、MMP-9的表达及意义

    Institute of Scientific and Technical Information of China (English)

    周钱宏; 刘爱东

    2009-01-01

    目的 探讨骨肉瘤中基质金属蛋白酶(MMP)-2及MMP-9的表达及其在骨肉瘤发生、发展中的作用.方法 采用免疫组织化学技术检测46例骨肉瘤组织及12例良性骨肿瘤组织中MMP-2及MMP-9的表达情况.结果 MMP-2及MMP-9在骨肉瘤中的表达量明显高于良性骨肿瘤组织,MMP-2及MMP-9的表达与Ennecking分期有关.结论 MMP-2及MMP-9可作为预测骨肉瘤预后的重要指标.

  13. The International Remote Monitoring Project -- First results of the Argentina nuclear power station field trial

    Energy Technology Data Exchange (ETDEWEB)

    Bonino, A.; Pizarro, L.; Perez, A. [Ente Nacional Regulador Nuclear, Buenos Aires (Argentina); Schoeneman, J.L.; Dupree, S.A.; Martinez, R.L. [Sandia National Labs., Albuquerque, NM (United States); Maxey, C. [Oak Ridge National Lab., TN (United States)

    1995-12-31

    As part of the International Remote Monitoring Project field trials, during the month of March, 1995 a Remote Monitoring System (RMS) was installed at the Embalse Nuclear Power Station in Embalse, Argentina. This system monitors the status of four typical Candu spent fuel dry storage silos. The monitoring equipment for each silo consists of analog temperature and gamma radiation sensors and digital motion and electronic fiber-optic seals connected to a wireless Authenticate Item Monitoring System (AIMS). All sensor data are authenticated and transmitted via RF link to Receiver Processor Units (RPU) coupled to Remote Monitoring System equipment located in a nearby IAEA/ENREN inspector office. One of these RPUs is connected to Remote Monitoring equipment capable of information transmission (via commercial telephone links) to Data Review Stations (DRS) at ENREN laboratories in Buenos Aires, Argentina, and at Sandia National Laboratories, Albuquerque, New Mexico. The other RPU is used for on-site data storage and analysis. It is anticipated that this information will soon be transmitted to a DRS at the ABACC facility in Rio de Janeiro, Brazil. During these trials site data will be collected and analyzed periodically from Buenos Aires, Albuquerque, and Rio de Janeiro. Installation detail and data analysis will be presented in this paper.

  14. Sustainable Seas Student Monitoring Project at the Branson School in Ross, CA

    Science.gov (United States)

    Rainsford, A.; Soave, K.; Costolo, R.; Kudler, J.; Emunah, M.; Hatfield, J.; Kiyasu, J.

    2015-12-01

    Alina Rainsford, Kathy Soave, Julia Kudler, Jane Hatfield, Melea Emunah, Rose Costelo, Jenna Kiyasu, Amy Dean and Sustainable Seas Monitoring Project, Branson School, Ross, CA, United States, Farallones Marine Sanctuary Association, San Francisco, CA, United StatesAbstract:The Sustainable Seas Student Monitoring Project at the Branson School in Ross, CA has monitored Duxbury Reef in Bolinas, CA since 1999, in cooperation with the Farallones Marine Sanctuary Association and the Gulf of Farallones National Marine Sanctuary. Goals of this student-run project include: 1) To monitor the rocky intertidal habitat and develop a baseline database of invertebrates and algal density and abundance; 2) To contribute to the conservation of the rocky intertidal habitat through education of students and visitors about intertidal species; 3) To increase stewardship in the Gulf of the Farallones National Marine Sanctuary; and 4) To contribute abundance and population data on key algae and invertebrate species to the national database, LiMPETS (Long Term Monitoring Program & Experiential Training for Students). Each fall student volunteers complete an intensive training course on the natural history of intertidal invertebrates and algae, identification of key species, rocky intertidal monitoring techniques, and history of the sanctuary. Students identify and count key invertebrate and algae species along two permanent transects and, using randomly determined points, within two permanent 200 m2 areas, in fall, winter, and late spring. Using data from the previous years, we will compare population densities, seasonal abundance and long-term population trends of key algal and invertebrate species, including Tegula funebralis, Anthopluera elegantissima, Cladophora sp. and Fucus sp.. Future analyses and investigations will include intertidal abiotic factors (including water temperature, pH and human foot-traffic) to enhance insights into the Duxbury Reef ecosystem, in particular, the high

  15. The LIFE ProjectMonitoring of insects with public participation” (MIPP: aims, methods and conclusions

    Directory of Open Access Journals (Sweden)

    Giuseppe Maria Carpaneto

    2017-08-01

    Full Text Available The Life ProjectMonitoring of insects with public participation” (LIFE11 NAT/IT/000252 had as the main objective to develop and test methods for the monitoring of five beetle species listed in the Annexes of the Habitats Directive (92/43/EEC: Osmoderma eremita (hermit beetle, Scarabaeidae, Lucanus cervus (European stag beetle, Lucanidae, Cerambyx cerdo (great capricorn beetle, Cerambycidae, Rosalia alpina (rosalia longicorn, Cerambycidae and Morimus asper/funereus (morimus longicorn, Cerambycidae. The data gathered represent an important contribution to the monitoring of these target species in Italy. The methods developed for monitoring of the target species are intended for use by the local management authorities and staff of protected areas. These developed methods are the result of extensive fieldwork and ensure scientific validity, ease of execution and limited labour costs. The detailed description of methods and the results for each species are published in separate articles of this special issue of Nature Conservation. A second objective of the project was to gather faunistic data with a Citizen Science approach, using the web and a mobile application software (app specifically built for mobile devices. The validation of the records collected by the citizens was carried out by experts, based on photographs, which were obligatory for all records. Dissemination activities represented the principal way to contact and engage citizens for the data collection and also offered the possibility of providing information on topics such as Natura 2000, the Habitats Directive, the role of monitoring in nature conservation, the importance of forest ecosystems and the ecological role of the saproxylic insects. An innovative method tested during the project was the training of a dog for searching and monitoring the elusive hermit beetle; the trained dog also added a “curiosity” factor to attract public attention towards this rare insect and

  16. Detection of MMP-8 via porous silicon microcavity devices functionalized with human antibodies

    Science.gov (United States)

    Martin, Marta; Taleb Bendiab, Chakib; Massif, Laurent; Cuisinier, Frédéric J. G.; Gergely, Csilla

    2010-04-01

    In this work we report on the fabrication of functionalized PSiMc scaffolds that can be used to enhance the detection of MMP-8. Matrix metalloproteinases (MMPs) are the major enzymes that degrade extracellular matrix (ECM) proteins and play a key role in diverse physiological and pathological processes. We are interested in detecting the collagenase-type MMP-8 that is an inflammatory marker in gingival fluid for predicting tooth movement during orthodontic treatment. As presence of an increasing amount of MMP-8 in saliva is directly related with the tooth movement during orthodontic treatment, monitoring continuously the MMP-8 variation is primordial. Porous silicon microcavity (PSiMc) structures were prepared as multilayered stacks of low and high refractive indices and with layer thicknesses in the order of visible light wavelength. Then the PSi surface was functionalized with human antibodies. Both functionalization and MMP-8 infiltration were monitored by specular reflectometry. PSiMc is characterized by a narrow resonance peak in the optical spectrum that is very sensitive to a small change in the refractive index, such as that obtained when a molecule is attached to the large internal surface of porous silicon. The pore dimensions of the used PSiMc structures were evaluated by atomic force microscopy (AFM) and scanning electron microscope (SEM).

  17. British Columbia S-2000 monitoring project, vol. 1, performance summary: Interim report, June 1993--December 1993

    Energy Technology Data Exchange (ETDEWEB)

    Makuch, P.D.

    1994-12-31

    The S-2000 program was established to promote cooperation between CANMET, electrical utilities, and provincial governments interested in evaluation on whether solar domestic hot water (SDHW) systems are suited to the reduction of peak electrical load levels and pollutant emission control through cost-effective energy displacement. Current activity consists of cooperative pilot projects between government and utilities to install and monitor several SDHW systems across Canada. As a first step to demonstrate the potential of SDHW in British Columbia, eight systems were purchased by B.C. Hydro and West Kootenay Power and installed on private residences throughout the province. This interim report summarizes the monitoring results from June-December 1993.

  18. The Transit Monitoring in the South (TraMoS project

    Directory of Open Access Journals (Sweden)

    López-Morales Mercedes

    2013-04-01

    Full Text Available We present the Transit Monitoring in the South (TraMoS project. TraMoS has monitored transits of 30 exoplanets with telescopes located in Chile since 2008, whit the following goals: (1 to refine the physical and/or orbital parameters of those exoplanet system, and (2 to search for variations in the mid-times of the transits and in other parameters such as orbital inclination or transit's depth, that could indicate the presence of additional bodies in the system. We highlight here the first results of TraMoS in three selected exoplanets.

  19. The Satellite based Monitoring Initiative for Regional Air quality (SAMIRA): Project summary and first results

    Science.gov (United States)

    Schneider, Philipp; Stebel, Kerstin; Ajtai, Nicolae; Diamandi, Andrei; Horalek, Jan; Nemuc, Anca; Stachlewska, Iwona; Zehner, Claus

    2017-04-01

    We present a summary and some first results of a new ESA-funded project entitled Satellite based Monitoring Initiative for Regional Air quality (SAMIRA), which aims at improving regional and local air quality monitoring through synergetic use of data from present and upcoming satellite instruments, traditionally used in situ air quality monitoring networks and output from chemical transport models. Through collaborative efforts in four countries, namely Romania, Poland, the Czech Republic and Norway, all with existing air quality problems, SAMIRA intends to support the involved institutions and associated users in their national monitoring and reporting mandates as well as to generate novel research in this area. The primary goal of SAMIRA is to demonstrate the usefulness of existing and future satellite products of air quality for improving monitoring and mapping of air pollution at the regional scale. A total of six core activities are being carried out in order to achieve this goal: Firstly, the project is developing and optimizing algorithms for the retrieval of hourly aerosol optical depth (AOD) maps from the Spinning Enhanced Visible and InfraRed Imager (SEVIRI) onboard of Meteosat Second Generation. As a second activity, SAMIRA aims to derive particulate matter (PM2.5) estimates from AOD data by developing robust algorithms for AOD-to-PM conversion with the support from model- and Lidar data. In a third activity, we evaluate the added value of satellite products of atmospheric composition for operational European-scale air quality mapping using geostatistics and auxiliary datasets. The additional benefit of satellite-based monitoring over existing monitoring techniques (in situ, models) is tested by combining these datasets using geostatistical methods and demonstrated for nitrogen dioxide (NO2), sulphur dioxide (SO2), and aerosol optical depth/particulate matter. As a fourth activity, the project is developing novel algorithms for downscaling coarse

  20. Project on restaurant energy performance: end-use monitoring and analysis. Appendixes I and II

    Energy Technology Data Exchange (ETDEWEB)

    Claar, C.N.; Mazzucchi, R.P.; Heidell, J.A.

    1985-05-01

    This is the second volume of the report, ''The Porject on Restaurant Energy Performance - End-Use Monitoring and Analysis''. The first volume (PNL-5462) contains a summary and analysis of the metered energy performance data collected by the Project on Restaurant Energy Performance (PREP). Appendix I, presented here, contains monitoring site descriptions, measurement plans, and data summaries for the seven restaurants metered for PREP. Appendix II, also in this volume, is a description of the PREP computer system.

  1. Project 57 Air Monitoring Report: October 1, 2013, through December 31, 2014

    Energy Technology Data Exchange (ETDEWEB)

    Mizell, Steve A. [Desert Research Inst. (DRI), Las Vegas, NV (United States); Nikolich, George [Desert Research Inst. (DRI), Las Vegas, NV (United States); McCurdy, Greg [Desert Research Inst. (DRI), Reno, NV (United States); Shadel, Craig [Desert Research Inst. (DRI), Las Vegas, NV (United States); Miller, Julianne J. [Desert Research Inst. (DRI), Las Vegas, NV (United States)

    2016-02-01

    On April 24, 1957, the Atomic Energy Commission (AEC, now the Department of Energy [DOE]) conducted the Project 57 safety experiment in western Emigrant Valley north east of the Nevada National Security Site (NNSS, formerly the Nevada Test Site) on lands withdrawn by the Department of Defense (DoD) for the Nevada Test and Training Range (NTTR). The test was undertaken to develop (1) a means of estimating plutonium distribution resulting from a nonnuclear detonation; (2) biomedical evaluation techniques for use in plutonium-laden environments; (3) methods of surface decontamination; and (4) instruments and field procedures for prompt estimation of alpha contamination (Shreve, 1958). Although the test did not result in the fission of nuclear materials, it did disseminate plutonium across the land surface. Following the experiment, the AEC fenced the contaminated area and returned control of the surrounding land to the DoD. Various radiological surveys have been performed in the area and in 2007, the DOE expanded the demarked contamination area by posting signs 200 to 400 feet (60 to 120 meters) outside of the original fence. Plutonium in soil is thought to attach preferentially to smaller particles. Therefore, redistribution of soil particulates by wind (dust) is the mechanism most likely to transport plutonium beyond the boundary of the Project 57 contamination area. In 2011, DRI installed two instrumentation towers to measure radiological, meteorological, and dust conditions. The monitoring activity was implemented to determine if radionuclide contamination was detectable in samples of airborne dust and characterize meteorological and environmental parameters that influence dust transport. Collected data also permits comparison of radiological conditions at the Project 57 monitoring stations to conditions observed at Community Environmental Monitoring Program (CEMP) stations around the NTTR. Biweekly samples of airborne particulates are submitted for laboratory

  2. Project 57 Air Monitoring Report: October 1, 2013, through December 31, 2014

    Energy Technology Data Exchange (ETDEWEB)

    Mizell, Steve A. [Desert Research Inst. (DRI), Las Vegas, NV (United States); Nikolich, George [Desert Research Inst. (DRI), Las Vegas, NV (United States); McCurdy, Greg [Desert Research Inst. (DRI), Reno, NV (United States); Shadel, Craig [Desert Research Inst. (DRI), Las Vegas, NV (United States); Miller, Julianne J. [Desert Research Inst. (DRI), Las Vegas, NV (United States)

    2016-02-01

    On April 24, 1957, the Atomic Energy Commission (AEC, now the Department of Energy [DOE]) conducted the Project 57 safety experiment in western Emigrant Valley north east of the Nevada National Security Site (NNSS, formerly the Nevada Test Site) on lands withdrawn by the Department of Defense (DoD) for the Nevada Test and Training Range (NTTR). The test was undertaken to develop (1) a means of estimating plutonium distribution resulting from a nonnuclear detonation; (2) biomedical evaluation techniques for use in plutonium-laden environments; (3) methods of surface decontamination; and (4) instruments and field procedures for prompt estimation of alpha contamination (Shreve, 1958). Although the test did not result in the fission of nuclear materials, it did disseminate plutonium across the land surface. Following the experiment, the AEC fenced the contaminated area and returned control of the surrounding land to the DoD. Various radiological surveys have been performed in the area and in 2007, the DOE expanded the demarked contamination area by posting signs 200 to 400 feet (60 to 120 meters) outside of the original fence. Plutonium in soil is thought to attach preferentially to smaller particles. Therefore, redistribution of soil particulates by wind (dust) is the mechanism most likely to transport plutonium beyond the boundary of the Project 57 contamination area. In 2011, DRI installed two instrumentation towers to measure radiological, meteorological, and dust conditions. The monitoring activity was implemented to determine if radionuclide contamination was detectable in samples of airborne dust and characterize meteorological and environmental parameters that influence dust transport. Collected data also permits comparison of radiological conditions at the Project 57 monitoring stations to conditions observed at Community Environmental Monitoring Program (CEMP) stations around the NTTR. Biweekly samples of airborne particulates are submitted for laboratory

  3. Limited independent prognostic value of MMP-14 and MMP-2 expression in ovarian cancer

    NARCIS (Netherlands)

    Vos, M.C.; Wurff, A.A. van der; Bulten, J.; Kruitwagen, R.; Feijen, H.; Kuppevelt, T.H. van; Hendriks, T.; Massuger, L.F.

    2016-01-01

    BACKGROUND: In cancer, various MMPs play a role in progression and metastasis and their overexpression generally indicates a poor prognosis. MMP-14 is the main activator of MMP-2 and both molecules play a role in normal ovarian follicular development. Earlier reports indicated a prognostic value for

  4. Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels

    NARCIS (Netherlands)

    Rutges, J. P. H. J.; Kummer, J. A.; Oner, F. C.; Verbout, A. J.; Roestenburg, H. J. A.; Dhert, W. J. A.; Creemers, L. B.

    2008-01-01

    Intervertebral disc (IVD) degeneration is associated with the increased expression of several matrix metalloproteinases (MMPs), in particular MMP-2. However, little is known about the actual activity of MMP-2 in healthy and degenerated discs, or what mechanisms are involved in its activation. A majo

  5. Project Monitor: Part II. Conservation in small business: an exploratory study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Hammond, P Y

    1979-08-01

    Project Monitor examined the energy conservation attitude and behavior of small samples of small business owners/operators in Allegheny County, Pennsylvania, focusing on manufacturing concerns and retailers. Section I reports the findings on the energy conserving behavior of 92 smaller manufacturers and Section II identifies the factors which affect decision making concerning energy consuming activities by the owners/operators of 94 small retail establishments. In each, the impact of Project Pacesetter and of the coal strike and the general energy situation is considered. (MCW)

  6. 哈萨克族食管癌中MMP-1、MMP-2、MMP-7、TIMP-1和MTA1的表达及其临床病理意义%The expression and significance of MMP.1, MMP.2, MMP.7,TIMP-1 and MTA1 in esophageal cancer of Kazaks

    Institute of Scientific and Technical Information of China (English)

    李秀梅; 陈艳; 王洪江; 庞作良; 李卉; 姜孝芳; 古丽努尔·木哈依; 谌宏鸣; 李惠武

    2011-01-01

    目的:探讨在新疆哈萨克族食管癌组织中基质金属蛋白酶1、2、7 (MMP-1、MMP-2、MMP-7)、基质金属蛋白酶抑制因子1(TIMP-1)和肿瘤转移相关基因1(MTA1)mRNA的表达及其临床意义.方法:采用RT-PCR方法检测75例哈萨克族食管癌标本中MMP-1、MMP-2、MMP-7、TIMP-1和MTA1 mRNA的表达水平,分析其表达与临床病理特征的关系.结果:MMP-1、MMP-2、MMP-7、TIMP-1和MTA1 mRNA在哈萨克族食管癌组织中的表达较正常组织增高,差异均具有统计学意义(P均<0.05);且MMP-2、MMP-7、MTA1 mRNA的表达与淋巴结转移有关(P<0.05),MMP-1、MMP-7 mRNA的表达与临床分期有关(P<0.05);TIMP-1与MMP-1、MMP-7、MTA1的表达呈正相关(r=0.446、0.458、0.333,P均<0.01).结论:MMP-1、MMP-2、MMP-7、TIMP-1和MTA1 mRNA表达上调共同参与了哈萨克族食管癌的发生发展过程;MMP-2、MMP-7和MTA1可能是哈萨克族食管癌发生侵袭、转移的主导因素.%OBJECTIVE:To study expressions of matrix metalloproteinasel, 2, 7 ( MMP-1, MMP-2, MMP-7), tissue inhibitor of matrix metallo proteinase 1(TIMP-1) and metastasis associated gene 1 (MTA1)in esophageal cancer tissue and normal tissue among Kazaks and to investigate the relationship between their expressions and clinical pathological features. METHODS: Using RT-PCR to detect the expressions of MMP-1, MMP-2, MMP-7, TIMP-1 and MTA1 in 75 esophageal cancer specimens. RESULTS: The mRNA expressions of MMP-1, MMP-2, MMP-7 , TIMP-1 and MTA1 in cancer tissue were higher than those of normal tissues(P<0.05). While the expression levels of MMP-2, MMP-7 and MTA1 mRNA were significantly related to the lymph node metastasis. The expression levels of MMP-1, MMP-7 mRNA were significantly related to the TNM stages(P < 0.05). The expression of TIMP-1 in the Kazak's esophageal cancer was positively related to the expressions of MMP-1, MMP-7, MTA1 (r=0.446、 0.458、 0.333, respectively, P<0.01). CONCLUSION: The overexpressions of MMP

  7. REDD+ readiness: early insights on monitoring, reporting and verification systems of project developers

    Science.gov (United States)

    Joseph, Shijo; Herold, Martin; Sunderlin, William D.; Verchot, Louis V.

    2013-09-01

    A functional measuring, monitoring, reporting and verification (MRV) system is essential to assess the additionality and impact on forest carbon in REDD+ (reducing emissions from deforestation and degradation) projects. This study assesses the MRV capacity and readiness of project developers at 20 REDD+ projects in Brazil, Peru, Cameroon, Tanzania, Indonesia and Vietnam, using a questionnaire survey and field visits. Nineteen performance criteria with 76 indicators were formulated in three categories, and capacity was measured with respect to each category. Of the 20 projects, 11 were found to have very high or high overall MRV capacity and readiness. At the regional level, capacity and readiness tended to be highest in the projects in Brazil and Peru and somewhat lower in Cameroon, Tanzania, Indonesia and Vietnam. Although the MRV capacities of half the projects are high, there are capacity deficiencies in other projects that are a source of concern. These are not only due to limitations in technical expertise, but can also be attributed to the slowness of international REDD+ policy formulation and the unclear path of development of the forest carbon market. Based on the study results, priorities for MRV development and increased investment in readiness are proposed.

  8. The monitoring evaluation, reporting and verification of climate change mitigation projects

    Energy Technology Data Exchange (ETDEWEB)

    Vine, E.; Sathaye, J.

    1998-05-01

    Because of concerns with the growing threat of global climate change from increasing emissions of greenhouse gases, the US and other countries are implementing, by themselves or in cooperation with one or more other nations, climate change mitigation projects. These projects will reduce greenhouse gas (GHG) emissions or sequester carbon, and will also result in non-GHG benefits (i.e., environmental, economic, and social benefits). Monitoring, evaluating, reporting, and verifying (MERV) guidelines are needed for these projects to accurately determine their net GHG, and other, benefits. Implementation of MERV guidelines is also intended to: (1) increase the reliability of data for estimating GHG benefits; (2) provide real-time data so that mid-course corrections can be made; (3) introduce consistency and transparency across project types and reporters; and (4) enhance the credibility of the projects with stakeholders. In this paper, the authors review the issues involved in MERV activities. They identify several topics that future protocols and guidelines need to address, such as: (1) establishing a credible baseline; (2) accounting for impacts outside project boundaries through leakage; (3) net GHG reductions and other benefits; (4) precision of measurement; (5) MERV frequency; (6) persistence (sustainability) of savings, emissions reduction, and carbon sequestration; (7) reporting by multiple project participants; (8) verification of GHG reduction credits; (9) uncertainty and risk; (10) institutional capacity in conducting MERV; and (11) the cost of MERV.

  9. DELIVERING TIMELY AIR QUALITY, TRAFFIC, AND WEATHER INFORMATION TO YOUR COMMUNITY/THE PASO DEL NORTE ENVIRONMENTAL MONITORING PROJECT

    Science.gov (United States)

    EPA has developed a technology transfer handbook for the EMPACT Paso del Norte Project. The EMPACT Paso del Norte Environmental Monitoring Project is a mobile vehicle emissions project that involves the international community of El Paso, TX; Sundland Park, NM; and Juarez, Mexico...

  10. Power monitoring and control for large scale projects: SKA, a case study

    Science.gov (United States)

    Barbosa, Domingos; Barraca, João. Paulo; Maia, Dalmiro; Carvalho, Bruno; Vieira, Jorge; Swart, Paul; Le Roux, Gerhard; Natarajan, Swaminathan; van Ardenne, Arnold; Seca, Luis

    2016-07-01

    Large sensor-based science infrastructures for radio astronomy like the SKA will be among the most intensive datadriven projects in the world, facing very high demanding computation, storage, management, and above all power demands. The geographically wide distribution of the SKA and its associated processing requirements in the form of tailored High Performance Computing (HPC) facilities, require a Greener approach towards the Information and Communications Technologies (ICT) adopted for the data processing to enable operational compliance to potentially strict power budgets. Addressing the reduction of electricity costs, improve system power monitoring and the generation and management of electricity at system level is paramount to avoid future inefficiencies and higher costs and enable fulfillments of Key Science Cases. Here we outline major characteristics and innovation approaches to address power efficiency and long-term power sustainability for radio astronomy projects, focusing on Green ICT for science and Smart power monitoring and control.

  11. Somebody is Watching EFL Classroom: A project on Improving Students’ Performance Level with a Monitoring System

    Directory of Open Access Journals (Sweden)

    Suna Akalın

    2011-04-01

    Full Text Available This study aims to explain a project on supporting students‟ speaking skills with a monitoring system. The monitoring system is aimed at controlling the usage of English continually in the afternoons, in weekdays, at a room which is being controlled by cameras. The absence of a teacher in the room is more comfortable than the cameras watching. This is a report of the Project implemented in the Department of teaching English, Ataturk University, Erzurum, Turkey. This study was conducted to find out how the usage of English in actual life situations contributes to learners‟ ability to develop their speaking abilities. The results revealed that learners‟ teacher‟s absence anxiety, instructor‟s attitude toward the speech room, course flexibility in the speech room, course quality, perceived usefulness and perceived ease of use, are the critical factors affecting learners‟ perceived satisfaction.

  12. Expressions of Matrix Metalloproteinases (MMP-2, MMP-7, and MMP-9 and Their Inhibitors (TIMP-1, TIMP-2 in Inflammatory Bowel Diseases

    Directory of Open Access Journals (Sweden)

    Katarzyna Jakubowska

    2016-01-01

    Full Text Available Crohn’s disease (CD and ulcerative colitis (UC belong to a group of inflammatory bowel diseases (IBD. The aim of our study was to evaluate the expression of MMP-2, MMP-7, MMP-9, TIMP-1, and TIMP-2 in ulcerative colitis and Crohn’s disease. The study group comprised 34 patients with UC and 10 patients with CD. Evaluation of MMP-2, MMP-7, MMP-9, TIMP-1, and TIMP-2 expression in tissue samples was performed using immunohistochemistry. The overexpression of MMP-9 and TIMP-1 was dominant in both the glandular epithelium and inflammatory infiltration in UC patients. In contrast, in CD subjects the positive expression of MMP-2 and TIMP-1 was in glandular tubes while mainly MMP-7 and TIMP-2 expression was in inflammatory infiltration. Metalloproteinases’ expression was associated with the presence of erosions, architectural tissue changes, and inflammatory infiltration in the lamina propria of UC patients. The expression of metalloproteinase inhibitors correlated with the presence of eosinophils and neutrophils in UC and granulomas in CD patients. Our studies indicate that the overexpression of metalloproteinases and weaker expression of their inhibitors may determine the development of IBD. It appears that MMP-2, MMP-7, and MMP-9 may be a potential therapeutic target and the use of their inhibitors may significantly reduce UC progression.

  13. Detection of gaps in the spatial coverage of coral reef monitoring projects in the US Caribbean and Gulf of Mexico.

    Science.gov (United States)

    Asch, R G; Turgeon, D D

    2003-06-01

    As part of the US Coral Reef Task Force's National Program to Map, Assess, Inventory, and Monitor US Coral Reef Ecosystems, a comprehensive survey of projects/programs monitoring coral reef ecosystems and related habitats (i.e., seagrass beds and mangroves) in the US Caribbean and Pacific was undertaken. Information was gathered on a total of 296 monitoring and assessment projects conducted since 1990 in the US Caribbean and the Gulf of Mexico. Substantial gaps in monitoring coverage of US coral reef ecosystems were revealed through geographic information system (GIS) analysis of survey metadata. Although southern Florida contains approximately two-thirds of all marine monitoring projects found in the US Caribbean and Gulf of Mexico, we were unable to identify any ongoing projects that monitor coral reefs along Florida's western coast and off of the Florida Middle Grounds. Additionally, Florida is covered by approximately 1 900 km2 of mangroves, yet there were only four ongoing projects that monitor this ecosystem, leaving gaps in coverage in the Lower and Middle Keys and along the eastern and western coasts. The Flower Garden Banks National Marine Sanctuary, located offshore of the Texas/Louisiana border, has an integral long-term monitoring program, but lacks a monitoring project that gathers long-term, quantitative data on reef lish abundance and certain water quality parameters. Numerous coral reef monitoring projects in Puerto Rico are concentrated on the island's southwestern coast surrounding La Parguera, while far fewer monitoring projects are conducted along the northern and southeastern coasts and around Vieques Island. In the US Virgin Islands, the paucity of monitoring projects in large areas of St. Croix and St. Thomas contrasts with monitoring activity in three marine protected areas (MPAs), where 66% of the US Virgin Islands' coral reef monitoring sites were found. Only a series of assessments have been conducted at Navassa, a small, uninhabited

  14. Sandia National Laboratories, California Quality Assurance Project Plan for Environmental Monitoring Program.

    Energy Technology Data Exchange (ETDEWEB)

    Holland, Robert C.

    2005-09-01

    This Quality Assurance Project Plan (QAPP) applies to the Environmental Monitoring Program at the Sandia National Laboratories/California. This QAPP follows DOE Quality Assurance Management System Guide for Use with 10 CFR 830 Subpart A, Quality Assurance Requirements, and DOE O 414.1C, Quality Assurance (DOE G 414.1-2A June 17, 2005). The Environmental Monitoring Program is located within the Environmental Operations Department. The Environmental Operations Department is responsible for ensuring that SNL/CA operations have minimal impact on the environment. The Department provides guidance to line organizations to help them comply with applicable environmental regulations and DOE orders. To fulfill its mission, the department has groups responsible for waste management; pollution prevention, air quality; environmental planning; hazardous materials management; and environmental monitoring. The Environmental Monitoring Program is responsible for ensuring that SNL/CA complies with all Federal, State, and local regulations and with DOE orders regarding the quality of wastewater and stormwater discharges. The Program monitors these discharges both visually and through effluent sampling. The Program ensures that activities at the SNL/CA site do not negatively impact the quality of surface waters in the vicinity, or those of the San Francisco Bay. The Program verifies that wastewater and stormwater discharges are in compliance with established standards and requirements. The Program is also responsible for compliance with groundwater monitoring, and underground and above ground storage tanks regulatory compliance. The Program prepares numerous reports, plans, permit applications, and other documents that demonstrate compliance.

  15. Automated chemical monitoring in new projects of nuclear power plant units

    Science.gov (United States)

    Lobanok, O. I.; Fedoseev, M. V.

    2013-07-01

    The development of automated chemical monitoring systems in nuclear power plant units for the past 30 years is briefly described. The modern level of facilities used to support the operation of automated chemical monitoring systems in Russia and abroad is shown. Hardware solutions suggested by the All-Russia Institute for Nuclear Power Plant Operation (which is the General Designer of automated process control systems for power units used in the AES-2006 and VVER-TOI Projects) are presented, including the structure of additional equipment for monitoring water chemistry (taking the Novovoronezh 2 nuclear power plant as an example). It is shown that the solutions proposed with respect to receiving and processing of input measurement signals and subsequent construction of standard control loops are unified in nature. Simultaneous receipt of information from different sources for ensuring that water chemistry is monitored in sufficient scope and with required promptness is one of the problems that have been solved successfully. It is pointed out that improved quality of automated chemical monitoring can be supported by organizing full engineering follow-up of the automated chemical monitoring system's equipment throughout its entire service life.

  16. Environmental monitoring for the DOE coolside and LIMB demonstration extension projects

    Energy Technology Data Exchange (ETDEWEB)

    White, T.; Contos, L.; Adams, L. (Radian Corp., Research Triangle Park, NC (United States). Progress Center)

    1992-02-01

    The purpose of this document is to present environmental monitoring data collected during the US DOE Limestone Injection Multistage Burner (LIMB) Demonstration Project Extension. The objective of the LIMB program is to demonstrate the sulfur dioxide (SO{sub 2}) and nitrogen oxide (NO{sub x}) emission reduction capabilities of the LIMB system. The LIMB system is a retrofit technology to be used for existing coal-fired boilers equipped with electrostatic precipitators. (VC)

  17. Expression and inhibition of matrix metalloproteinase (MMP)-8, MMP-9 and MMP-12 in early colonic anastomotic repair

    DEFF Research Database (Denmark)

    Krarup, Peter-Martin; Eld, Mikkel; Heinemeier, Katja

    2013-01-01

    Submucosal collagen is paramount for colonic anastomotic integrity. Matrix metalloproteinases (MMPs) mediate collagen degradation that increases the risk of wound dehiscence. Although broad-spectrum MMP inhibitors are beneficial for anastomotic strength, they can cause adverse reactions. Knowledge...... of specific MMPs responsible for the weakening of anastomoses can be used to optimise MMP inhibition therapy. We aimed to quantify transcript and protein levels of multiple MMPs in colonic anastomoses and evaluate the effect of inhibiting the MMPs that displayed the highest expression levels on anastomotic...

  18. Near-surface monitoring for the ZERT shallow CO2 injection project

    Energy Technology Data Exchange (ETDEWEB)

    Strazisar, Brian R. [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United States); Wells, Arthur W. [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United States); Diehl, J. Rodney [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United States); Hammack, Richard W. [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United States); Veloski, Garret A. [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United States)

    2009-12-01

    As part of a collaborative effort operated by the Zero Emission Research and Technology Center (ZERT), a series of two shallow releases of CO2 Was performed at a test site in Bozeman, MT. The purpose of the experiment was to simulate possible leakage scenarios from a carbon capture and storage operation in order to further develop and verify monitoring technologies used to characterize and quantify the release of CO2. The project included collaboration with several research groups and organizations. Presented here are the results of soil-gas monitoring conducted by researchers from the National Energy Technology Laboratory, including CO2 flux measurement, soil-gas analysis, perfluorocarbon tracer monitoring, and soil resistivity measurements. Together, these methods proved to be effective in detecting and characterizing leakage in the near-surface.

  19. 2008 Groundwater Monitoring Report Project Shoal Area, Corrective Action Unit 447

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-03-01

    This report presents the 2008 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) at the Project Shoal Area (PSA) Subsurface Corrective Action Unit (CAU) 447 located in Churchill County, Nevada. Responsibility for the environmental site restoration of the PSA was transferred from the DOE Office of Environmental Management to LM on October 1, 2006. The environmental restoration process and corrective action strategy for CAU 447 are conducted in accordance with the Federal Facility Agreement and Consent Order (FFACO 1996, as amended February 2008) entered into by DOE, the U.S. Department of Defense, and the State of Nevada. The corrective action strategy for the site includes proof of concept monitoring in support of site closure. This report summarizes investigation activities associated with CAU 447 that were conducted at the site during 2008. This is the second groundwater monitoring report prepared by LM for the PSA

  20. The Project Monitoring and Early Warning System of Mould and Die

    Institute of Scientific and Technical Information of China (English)

    WANG Zongzhong; WANG Yi; CHEN Qingxin; MAO Ning

    2006-01-01

    The article simply describes the difficulties of the Mould and Die project control, and then put forward the thoughts of developing the Monitoring and Early Warning System for the Mould and Die manufacturing. Afterwards, the main three constructing principles and the goals of the system are explained carefully. Based on those, the theory and the classifications of the Monitoring and Early Warning are expounded. With the assistance of the use case diagram of UML (the United Modeling Language), the main functions of the system are analyzed; and with the activity diagram of the UML, the work flows of the monitoring and early warning are expressed clearly. Finally, the classes and the architectures of the system are designed by making use of the class diagram of UML.

  1. Fish Research Project Oregon; Umatilla Hatchery Monitoring and Evaluation, 1992 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Keefe, MaryLouise; Carmichael, Richard W.; French, Rod A. (Oregon Department of Fish and Wildlife, Portland, OR)

    1993-03-01

    This report covers the first year of comprehensive monitoring and evaluation of the Umatilla Hatchery. As both the hatchery and the evaluation study are in the early stages of implementation, much of the information contained in this report is preliminary. The most crucial data for evaluating the success of the hatchery program, the data on post-release performance and survival, is yet unavailable. In addition, several years of data are necessary to make conclusions about rearing performance at Umatilla Hatchery. The conclusions drawn in this report should be viewed as preliminary and should be used in conjunction with additional information as it becomes available. A comprehensive fish health monitoring regimen was incorporated into the monitoring and evaluation study for Umatilla Hatchery. This is a unique feature of the Umatilla Hatchery evaluation project.

  2. 2010 Groundwater Monitoring Report Project Shoal Area, Corrective Action Unit 447

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-02-01

    This report presents the 2010 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) at the Project Shoal Area (PSA) Subsurface Corrective Action Unit (CAU) 447 in Churchill County, Nevada. Responsibility for the environmental site restoration of the PSA was transferred from the DOE Office of Environmental Management to LM on October 1, 2006. The environmental restoration process and corrective action strategy for CAU 447 are conducted in accordance with the Federal Facility Agreement and Consent Order (FFACO 1996, as amended March 2010) entered into by DOE, the U.S. Department of Defense, and the State of Nevada. The corrective action strategy for the site includes monitoring in support of site closure. This report summarizes the results from the groundwater monitoring program during fiscal year 2010.

  3. MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis.

    Directory of Open Access Journals (Sweden)

    Ivan O Rosas

    2008-04-01

    Full Text Available BACKGROUND: Idiopathic pulmonary fibrosis (IPF is a chronic progressive fibrotic lung disease associated with substantial morbidity and mortality. The objective of this study was to determine whether there is a peripheral blood protein signature in IPF and whether components of this signature may serve as biomarkers for disease presence and progression. METHODS AND FINDINGS: We analyzed the concentrations of 49 proteins in the plasma of 74 patients with IPF and in the plasma of 53 control individuals. We identified a combinatorial signature of five proteins-MMP7, MMP1, MMP8, IGFBP1, and TNFRSF1A-that was sufficient to distinguish patients from controls with a sensitivity of 98.6% (95% confidence interval [CI] 92.7%-100% and specificity of 98.1% (95% CI 89.9%-100%. Increases in MMP1 and MMP7 were also observed in lung tissue and bronchoalveolar lavage fluid obtained from IPF patients. MMP7 and MMP1 plasma concentrations were not increased in patients with chronic obstructive pulmonary disease or sarcoidosis and distinguished IPF compared to subacute/chronic hypersensitivity pneumonitis, a disease that may mimic IPF, with a sensitivity of 96.3% (95% CI 81.0%-100% and specificity of 87.2% (95% CI 72.6%-95.7%. We verified our results in an independent validation cohort composed of patients with IPF, familial pulmonary fibrosis, subclinical interstitial lung disease (ILD, as well as with control individuals. MMP7 and MMP1 concentrations were significantly higher in IPF patients compared to controls in this cohort. Furthermore, MMP7 concentrations were elevated in patients with subclinical ILD and negatively correlated with percent predicted forced vital capacity (FVC% and percent predicted carbon monoxide diffusing capacity (DLCO%. CONCLUSIONS: Our experiments provide the first evidence for a peripheral blood protein signature in IPF to our knowledge. The two main components of this signature, MMP7 and MMP1, are overexpressed in the lung

  4. MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis.

    Science.gov (United States)

    Rosas, Ivan O; Richards, Thomas J; Konishi, Kazuhisa; Zhang, Yingze; Gibson, Kevin; Lokshin, Anna E; Lindell, Kathleen O; Cisneros, Jose; Macdonald, Sandra D; Pardo, Annie; Sciurba, Frank; Dauber, James; Selman, Moises; Gochuico, Bernadette R; Kaminski, Naftali

    2008-04-29

    Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease associated with substantial morbidity and mortality. The objective of this study was to determine whether there is a peripheral blood protein signature in IPF and whether components of this signature may serve as biomarkers for disease presence and progression. We analyzed the concentrations of 49 proteins in the plasma of 74 patients with IPF and in the plasma of 53 control individuals. We identified a combinatorial signature of five proteins-MMP7, MMP1, MMP8, IGFBP1, and TNFRSF1A-that was sufficient to distinguish patients from controls with a sensitivity of 98.6% (95% confidence interval [CI] 92.7%-100%) and specificity of 98.1% (95% CI 89.9%-100%). Increases in MMP1 and MMP7 were also observed in lung tissue and bronchoalveolar lavage fluid obtained from IPF patients. MMP7 and MMP1 plasma concentrations were not increased in patients with chronic obstructive pulmonary disease or sarcoidosis and distinguished IPF compared to subacute/chronic hypersensitivity pneumonitis, a disease that may mimic IPF, with a sensitivity of 96.3% (95% CI 81.0%-100%) and specificity of 87.2% (95% CI 72.6%-95.7%). We verified our results in an independent validation cohort composed of patients with IPF, familial pulmonary fibrosis, subclinical interstitial lung disease (ILD), as well as with control individuals. MMP7 and MMP1 concentrations were significantly higher in IPF patients compared to controls in this cohort. Furthermore, MMP7 concentrations were elevated in patients with subclinical ILD and negatively correlated with percent predicted forced vital capacity (FVC%) and percent predicted carbon monoxide diffusing capacity (DLCO%). Our experiments provide the first evidence for a peripheral blood protein signature in IPF to our knowledge. The two main components of this signature, MMP7 and MMP1, are overexpressed in the lung microenvironment and distinguish IPF from other chronic lung diseases

  5. Monitoring and Evaluation : Yakima/Klickitat Fisheries Project, Final Report 2000.

    Energy Technology Data Exchange (ETDEWEB)

    Sampson, Melvin R.

    2000-01-01

    The monitoring and evaluation objectives and tasks have been developed through a joint process between the co-managers, Yakama Nation (YN, Lead Agency) and Washington Department of Fish and Wildlife (WDFW). The Science/Technical Advisory Committee (STAC), which consists of core members from the co-managers, employs the services of a work committee of scientists, the Monitoring Implementation Planning Team (MIPT) to develop the Monitoring and Evaluation (M&E) Plan. The process employed by STAC to verify these designated activities and the timing of their implementation involved the utilization of the following principles: (1) YKFP monitoring should evaluate the success (or lack of it) of project supplementation efforts and its impacts, including juvenile post release survival, natural production and reproductive success, ecological interactions, and genetics; (2) YKFP monitoring should be comprehensive: and, (3) YKFP monitoring should be done in such a way that results are of use to salmon production efforts throughout and Columbia basin and the region. Utilizing these principles, STAC and MIPT developed this M&E action plan in three phases. The first phase was primarily conceptual. STAC and MIPT defined critical issues and problems and identified associated response variables. The second phase was quantitative, which determined the scale and size of an effective monitoring effort. A critical element of the quantitative phase was an assessment of the precision with which response variables can be measured, the probability of detecting real impacts and the sample sizes required for a given level of statistical precision and power. The third phase is logistical. The feasibility of monitoring measures was evaluated as to practicality and cost. The Policy Group has determined that the M&E activities covered by this agreement are necessary, effective and cost-efficient.

  6. Monitoring and Evaluation : Yakima/Klickitat Fisheries Project, Annual Report 2001.

    Energy Technology Data Exchange (ETDEWEB)

    Sampson, Melvin R.

    2002-12-01

    The monitoring and evaluation objectives and tasks have been developed through a joint process between the co-managers, Yakama Nation (YN, Lead Agency) and Washington Department of Fish and Wildlife (WDFW). The Science/Technical Advisory Committee (STAC), which consists of core members from the co-managers, employs the services of a work committee of scientists, the Monitoring Implementation Planning Team (MIPT) to develop the Monitoring and Evaluation (M&E) Plan. The process employed by STAC to verify these designated activities and the timing of their implementation involved the utilization of the following principles: (1) YKFP monitoring should evaluate the success (or lack of it) of project supplementation efforts and its impacts, including juvenile post release survival, natural production and reproductive success, ecological interactions, and genetics; (2) YKFP monitoring should be comprehensive: and, (3) YKFP monitoring should be done in such a way that results are of use to salmon production efforts throughout and Columbia basin and the region. Utilizing these principles, STAC and MIPT developed this M&E action plan in three phases. The first phase was primarily conceptual. STAC and MIPT defined critical issues and problems and identified associated response variables. The second phase was quantitative, which determined the scale and size of an effective monitoring effort. A critical element of the quantitative phase was an assessment of the precision with which response variables can be measured, the probability of detecting real impacts and the sample sizes required for a given level of statistical precision and power. The third phase is logistical. The feasibility of monitoring measures was evaluated as to practicality and cost. The Policy Group has determined that the M&E activities covered by this agreement are necessary, effective and cost-efficient.

  7. The Navruz Project: Transboundary Monitoring for Radionuclides and Metals in Central Asia Rivers. Data Report

    Energy Technology Data Exchange (ETDEWEB)

    Passell, Howard D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Barber, David S. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Betsill, J. David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Littlefield, Adriane C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Mohagheghi, Amir H. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Shanks, Sonoya T. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Yuldashev, Bekhzad [Inst. of Nuclear Physics, Tashkent (Uzbekistan); Saalikhbaev, Umar [Inst. of Nuclear Physics, Tashkent (Uzbekistan); Radyuk, Raisa [Inst. of Nuclear Physics, Tashkent (Uzbekistan); Djuraev, Akram [Tajik Academy of Sciences, Dushanbe (Tajikistan); Djuraev, Anwar [Tajik Academy of Sciences, Dushanbe (Tajikistan); Vasilev, Ivan [Inst. of Physics, Bishkek (Kyrgyzstan); Tolongutov, Bajgabyl [Inst. of Physics, Bishkek (Kyrgyzstan); Valentina, Alekhina [Inst. of Physics, Bishkek (Kyrgyzstan); Solodukhin, Vladimir [Inst. of Nuclear Physics, Almaty (Kazakhstan); Pozniak, Victor [Inst. of Nuclear Physics, Almaty (Kazakhstan)

    2003-04-01

    The Navruz Project is a cooperative, transboundary, river monitoring project involving rivers and institutions in Kazakhstan, Kyrgyzstan, Tajikistan, and Uzbekistan, and facilitated by Sandia National Laboratories in the U.S. The Navruz Project focuses on waterborne radionuclides and metals because of their importance to public health and nuclear materials proliferation concerns in the region. The Project also collects data on basic water quality parameters. Data obtained in this project are shared among all participating countries and the public through a world-wide web site (http://www.cmc.sandia.org/Central/centralasia.html), and are available for use in further studies and in regional transboundary water resource management efforts. This report includes graphs showing selected data from the Fall 2000 and Spring 2001 sampling seasons. These data include all parameters grouped into six regions, including main rivers and some tributaries in the Amu Darya and Syr Darya river systems. This report also assembles all data (in tabular form) generated by the project from Fall 2000 through Fall 2001. This report comes as the second part of a planned three-part reporting process. The first report is the Sampling and Analysis Plan and Operational Manual, SAND 2002-0484. This is the second report.

  8. Results of the MITRA project: Monitoring and intervention for the transportation of dangerous goods

    Energy Technology Data Exchange (ETDEWEB)

    Planas, E. [Centre d' Estudis del Risc Tecnologic (CERTEC), Departament d' Enginyeria Quimica, Universitat Politecnica de Catalunya, Diagonal 647, 08028-Barcelona, Catalonia (Spain)], E-mail: eulalia.planas@upc.edu; Pastor, E. [Centre d' Estudis del Risc Tecnologic (CERTEC), Departament d' Enginyeria Quimica, Universitat Politecnica de Catalunya, Diagonal 647, 08028-Barcelona, Catalonia (Spain); Presutto, F. [M3 Systems, 1 Rue des Oiseaux, 31410 Lavernose (France); Tixier, J. [Ecole des Mines d' Ales, Ales (France)

    2008-04-01

    The objective of the MITRA (monitoring and intervention for the transportation of dangerous goods) project was to prototype a new operational system for monitoring the transportation of dangerous goods in Europe based on regional responsibilities. This concept, based on systems used in air traffic control, aims to provide civil security centres with real-time knowledge of the position and contents of dangerous vehicles circulating in their area of responsibility, and, in the event of a dangerous situation, to issue warnings, alerts and crisis management information, thereby allowing intervention teams to react immediately with maximum safety. The project was funded by the European Commission under the 6th Framework Programme (STREP - specific targeted research project - under the Information Society Technologies priority). It started on 1 September 2004 and ended on 31 October 2006. This paper presents the results of this project and the conclusions derived from the field tests carried out in Germany and in the French/Spanish border region in order to test the proposed operational system.

  9. Environmental monitoring for the DOE coolside and LIMB demonstration extension projects

    Energy Technology Data Exchange (ETDEWEB)

    White, T.; Contos, L.

    1991-09-01

    The purpose of this document is to present environmental monitoring data collected during the US Department of Energy Limestone Injection Multistage Burner (DOE LIMB) Demonstration Project Extension at the Ohio Edison Edgewater Generating Station in Lorain, Ohio. These data were collected by implementing the Environmental Monitoring Plan (EMP) for the DOE LIMB Demonstration Project Extension, dated August 1988. This document is the fifth EMP status report to be published and presents the data generated during November and December 1990, and January 1991. These reports review a three or four month period and have been published since the project's start in October 1989. The DOE project is an extension of the US Environmental Protection Agency's (EPA) original LIMB Demonstration. The program is operated under DOE's Clean Coal Technology Program of emerging clean coal technologies'' under the categories of in boiler control of oxides of sulfur and nitrogen'' as well as post-combustion clean-up.'' The objective of the LIMB program is to demonstrate the sulfur dioxide (SO{sub 2}) and nitrogen oxide (NO{sub x}) emission reduction capabilities of the LIMB system. The LIMB system is a retrofit technology to be used for existing coal-fired boilers equipped with electrostatic precipitators (ESPs). 5 figs., 12 tabs.

  10. The CHAIN-Project and Installation of Flare Monitoring Telescopes in Developing Countries

    Directory of Open Access Journals (Sweden)

    S UeNo

    2009-04-01

    Full Text Available The Flare Monitoring Telescope (FMT was constructed in 1992 at Hida Observatory in Japan to investigate the long-term variation of solar activity and explosive events. It has five solar imaging telescopes that simultaneously observe the full-disk Sun at different wavelengths around the H-alpha absorption line or in different modes. Therefore, the FMT can measure the three-dimensional velocity field of moving structures on the full solar disk. The science target of the FMT is to monitor solar flares and erupting filaments continuously all over the solar disk and to investigate correlation between the characteristics of the erupting phenomena and the geoeffectiveness of the corresponding coronal mass ejections (CMEs. We are planning to start up a new worldwide project, the Continuous H-alpha Imaging Network (CHAIN project, as an important IHY project of our observatories. As part of this project, we are examining the possibility of installing telescopes similar to the FMT in developing countries. We have selected Peru and Algeria as the countries where the first and second overseas FMTs will be installed, and we are aiming to start operation of these FMTs by the end of 2010 before the maximum phase of solar cycle 24. To create such an international network, it will be necessary to improve the information technologies applied in our observation-system. In this paper, we explain the current status and future areas of work regarding our system.

  11. Web based concept project for information and communication of monitoring policy and techniques

    Energy Technology Data Exchange (ETDEWEB)

    Levy, D. S.; Sordi, G. M. A. A., E-mail: info@uniprorad.com.br [Instituto de Pesquisas Energeticas e Nucleares / CNEN, Av. Lineu Prestes 2242, Cidade Universitaria, 05508-000 Sao Paulo (Brazil)

    2014-08-15

    Information and Communication Technology (ICT) is growing in Brazil and worldwide. The servers processing power added to the technology of relational databases allow to integrate information from different sources, enabling complex queries with reduced response time. We believe that the use of information technology for the radiological protection programs for human activities shall help greatly the radioactive facility that requires such use. Therefore, this project aims the informatization of the monitoring policy and techniques in Portuguese, providing Brazilian radioactive facilities a complete repository for research, consultation and information in a quick, integrated and efficient way. In order to meet national and international standards, the development of this project includes concepts, definitions and theory about monitoring procedures in order to interrelate information, currently scattered in several publications and documents, in a consistent and appropriate manner. The Web platform tools and functionalities were developed according to our target public needs, regarding new possibilities of media, like mobile access, feeds of content and information sharing. Moreover, taking into account this is a pioneer project with the prospect of long-term use, our challenge involves the combination of multiple computer technologies that allows a robust, effective, and flexible system, which can be easily adapted according to future technological innovations. This pioneer project shell help greatly both radioactive facilities and researchers, and it is our target to make it an international reference for Portuguese Spoken countries. (Author)

  12. Development of Distributed Research Center for monitoring and projecting regional climatic and environmental changes: first results

    Science.gov (United States)

    Gordov, Evgeny; Shiklomanov, Alexander; Okladinikov, Igor; Prusevich, Alex; Titov, Alexander

    2016-04-01

    Description and first results of the cooperative project "Development of Distributed Research Center for monitoring and projecting of regional climatic and environmental changes" recently started by SCERT IMCES and ESRC UNH are reported. The project is aimed at development of hardware and software platform prototype of Distributed Research Center (DRC) for monitoring and projecting regional climatic and environmental changes over the areas of mutual interest and demonstration the benefits of such collaboration that complements skills and regional knowledge across the northern extratropics. In the framework of the project, innovative approaches of "cloud" processing and analysis of large geospatial datasets will be developed on the technical platforms of two U.S. and Russian leading institutions involved in research of climate change and its consequences. Anticipated results will create a pathway for development and deployment of thematic international virtual research centers focused on interdisciplinary environmental studies by international research teams. DRC under development will comprise best features and functionality of earlier developed by the cooperating teams' information-computational systems RIMS (http://rims.unh.edu) and CLIMATE(http://climate.scert.ru/), which are widely used in Northern Eurasia environment studies. The project includes several major directions of research (Tasks) listed below. 1. Development of architecture and defining major hardware and software components of DRC for monitoring and projecting of regional environmental changes. 2. Development of an information database and computing software suite for distributed processing and analysis of large geospatial data hosted at ESRC and IMCES SB RAS. 3. Development of geoportal, thematic web client and web services providing international research teams with an access to "cloud" computing resources at DRC; two options will be executed: access through a basic graphical web browser and

  13. Expression and significance of Twist、MMP-2 and MMP -9 in breast cancer%乳腺癌组织中Twist、MMP-2和MMP-9的表达及意义

    Institute of Scientific and Technical Information of China (English)

    艾斯卡尔·阿尤甫; 古力米热·布然江; 欧江华

    2012-01-01

    Objective To investigate the expression and significance of Twist, MMP - 2 and MMP -9 in Breast Cancer . Methods Immunohislochemical SP method was used to examine the levels of Twist protein, MMP - 2, MMP - 9 in Breast Cancer (70 cases) and paracancerous normal tissues (35 cases) . Results The positive rates of Twist, MMP - 2 and MMP - 9 were higher in Breast Cancer than thouse in the tumor - adjacent normal tissues (72. 9% ,55.1% ,67. 1% vs 16.7% ,28. 6% ,37. 1% ,P < 0.05). Their expressions were positively correlated with the tumor differentiation, the depth of invasion lymph node metastasis (P < 0. 05). Expression of MMP - 2 was positively correlated with that of MMP - 9 (P <0.05). Conclusions The aberrant expressions of Twist,MMP -2 and MMP -9 may play a cooperative role in the infiltration and metastasis of Breast Cancer, which may be taken as a reference index for e-valuating the metastasis and prognosis.%目的 探讨乳腺癌组织中Twist、MMP -2和MMP -9表达的相关性.方法 采用SP免疫组化法检测70例乳腺癌组织(35例癌旁组织作为对照)中Twist、MMP -2和MMP -9的表达情况.结果 乳腺癌组织中Twist、MMP -2和MMP-9的阳性表达率分别为72.9%、55.7%和67.1%,均显著高于癌旁正常组织中的16.7%、28.6%和37.10%(P<0.05).Twist、MMP -2和MMP-9与肿瘤的分化程度、浸润深度和淋巴结转移有关(P<0.05).Twist的表达与MMP -2和MMP -9的表达呈正相关.MMP -2的表达与MMP -9的表达呈正相关.结论 Twist、MMP -2和MMP -9在肿瘤细胞发生浸润转移中有协同作用,可作为评估乳腺癌转移及预后的参考指标.

  14. Expression of MMP-2 and MMP-9 in Cutaneous Malignant Melanoma and its Significance%MMP-2和MMP-9在皮肤恶性黑色素瘤中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    宋宁静; 王晓楠; 陈佳; 吴正升; 章楚光

    2011-01-01

    目的 研究明胶酶(MMP-2和MMP-9)在皮肤黑色素瘤和色素痣组织中的蛋白表达及其意义.方法 应用免疫组织化学S-P法检测90例皮肤黑色素瘤和43例皮肤色素痣组织MMP-2和MMP-9的表达情况,分析它们与患者临床病理特征的关系.结果 皮肤黑色素瘤组织MMP-2和MMP-9蛋白表达阳性率分别为50.0%和55.6%,显著高于色素痣的阳性率27.9%和25.6%(P<0.05和P<0.01);黑色素瘤MMP-2和MMP-9蛋白表达均与肿瘤的浸润深度和淋巴结转移呈正相关(均P<0.05).结论 皮肤恶性黑色素瘤MMP-2和MMP-9表达状况与肿瘤侵袭、转移呈密切相关,提示MMP-2和MMP-9可能在黑色素瘤发生发展过程中发挥了重要作用.%Objective To investigate the expression of MMP-2 and MMP-9 protein in cutaneous melanoma and its significance.Methods The expression of MMP-2 and MMP-9 protein was detected in 90 cases of melanoma and 47 cases of nevus by using streptavidin-peroxidase technique. Their correlations with the clinicopathological features were analyzed. Results The positive rates of MMP-2 and MMP-9 protein in the melanomas were 50.0% and 55.6% ,which were significantly higher than those in the nevus. Both t MMP-2 and MMP-9 protein was positively correlated to the depth of tumour invasion and the lymph node metastasis of melanoma( All P < 0.05). Conclusion The expression of MMP-2 and MMP-9 is closely correlated to the tumout invasion and metastasis. The result suggests that MMP-2 and MMP-9 might play an important role in the cutaneous melanoma development and progression.

  15. Acoustic Monitoring of Beluga Whale Interactions with Cook Inlet Tidal Energy Project

    Energy Technology Data Exchange (ETDEWEB)

    Worthington, Monty [Project Director - AK

    2014-02-05

    Cook Inlet, Alaska is home to some of the greatest tidal energy resources in the U.S., as well as an endangered population of beluga whales (Delphinapterus leucas). Successfully permitting and operating a tidal power project in Cook Inlet requires a biological assessment of the potential and realized effects of the physical presence and sound footprint of tidal turbines on the distribution, relative abundance, and behavior of Cook Inlet beluga whales. ORPC Alaska, working with the Project Team—LGL Alaska Research Associates, University of Alaska Anchorage, TerraSond, and Greeneridge Science—undertook the following U.S. Department of Energy (DOE) study to characterize beluga whales in Cook Inlet – Acoustic Monitoring of Beluga Whale Interactions with the Cook Inlet Tidal Energy Project (Project). ORPC Alaska, LLC, is a wholly-owned subsidiary of Ocean Renewable Power Company, LLC, (collectively, ORPC). ORPC is a global leader in the development of hydrokinetic power systems and eco-conscious projects that harness the power of ocean and river currents to create clean, predictable renewable energy. ORPC is developing a tidal energy demonstration project in Cook Inlet at East Foreland where ORPC has a Federal Energy Regulatory Commission (FERC) preliminary permit (P-13821). The Project collected baseline data to characterize pre-deployment patterns of marine mammal distribution, relative abundance, and behavior in ORPC’s proposed deployment area at East Foreland. ORPC also completed work near Fire Island where ORPC held a FERC preliminary permit (P-12679) until March 6, 2013. Passive hydroacoustic devices (previously utilized with bowhead whales in the Beaufort Sea) were adapted for study of beluga whales to determine the relative abundance of beluga whale vocalizations within the proposed deployment areas. Hydroacoustic data collected during the Project were used to characterize the ambient acoustic environment of the project site pre-deployment to inform the

  16. Association of MMP-8 with obesity, smoking and insulin resistance.

    Science.gov (United States)

    Lauhio, Anneli; Färkkilä, Esa; Pietiläinen, Kirsi H; Åström, Pirjo; Winkelmann, Alina; Tervahartiala, Taina; Pirilä, Emma; Rissanen, Aila; Kaprio, Jaakko; Sorsa, Timo A; Salo, Tuula

    2016-09-01

    Obesity has been recognized as a state of subclinical inflammation resulting in a loss of insulin receptors and decreased insulin sensitivity. We here studied in vivo the role of circulating matrix metalloproteinase-8 (MMP-8) among young healthy twin adults. Also, in vitro analysis of the cleavage of human insulin receptor (INSR) by MMP-8 was investigated as well its inhibition by doxycycline and other MMP-8 inhibitor, Ilomastat/GM6001, which are broad-spectrum MMP inhibitors. We analysed serum MMP-8 levels by a time-resolved immunofluorometric assay in obese (n = 34), overweight (n = 76) and normal weight (n = 130) twin individuals. The effect of MMP-8 on INSR and the effects of synthetic MMP-8 inhibitors, doxycycline and Ilomastat/GM6001, were studied by SDS-PAGE. We found that in obese individuals relative to normal weight individuals, the serum MMP-8 levels and MMP-8/TIMP-1 ratio were significantly increased (P = 0·0031 and P = 0·031, respectively). Among normal weight and obese individuals, also smoking significantly increases serum MMP-8 and MMP-8/TIMP-1 ratio. In vitro, we found that INSR was degraded by MMP-8 and this was inhibited by doxycycline and Ilomastat/GM6001. Obesity associated with elevated circulating MMP-8 found among young adults may contribute to progression of insulin resistance by cleaving INSR. This INSR cleavage by MMP-8 can be inhibited by synthetic MMP-8 inhibitors such as doxycycline. In addition to obesity, also smoking independently explained increased MMP-8 levels. Our results suggest that MMP-8 is an essential mediator in systemic subclinical inflammatory response in obesity, and a potential drug target. © 2016 Stichting European Society for Clinical Investigation Journal Foundation.

  17. MMP-2及MMP-7在食管癌及癌旁组织中的表达%Expressions of MMP-7 and MMP-2 in esophageal cancer patients

    Institute of Scientific and Technical Information of China (English)

    孙晓宏; 庞作良; 罗洞波

    2010-01-01

    目的 探讨MMP-7和MMP-2在食管癌中的表达及其相互关联.方法 采用RT-PCR方法检测MMP-7和MMP-2在60例食管癌组织及其相应癌旁组织中的表达.结果 MMP-7和MMP-2在癌组织中阳性率分别为90.0%(54/60)和91.7%(55/60),在其对应癌旁组织中的阳性率为48.3%(29/60)和65.0%(39/60).通过RT-PCR半定量分析癌组织及其相应的癌旁组织中MMP-7和MMP-2的表达量,差异有统计学意义(P<0.05).MMP-7的表达与肿瘤浸润深度及淋巴结转移有关(P<0.05).MMP-2与MMP-7表达呈正相关.结论 MMP-7和MMP-2的表达可能与食管癌的早期进展和程度有关.

  18. Yakima/Klickitat Fisheries Project - Klickitat Monitoring and Evaluation, 2007 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Zendt, Joe; Babcock, Mike [Yakama Nation Fisheries Resource Management

    2006-04-02

    This report describes the results of monitoring and evaluation (M&E) activities for salmonid fish populations and habitat in the Klickitat River subbasin in south-central Washington. The M&E activities described here were conducted as a part of the Bonneville Power Administration (BPA)-funded Yakima/Klickitat Fisheries Project (YKFP) and were designed by consensus of the scientists with the Yakama Nation (YN) Fisheries Program. YKFP is a joint project between YN and Washington Department of Fish and Wildlife (WDFW). Overall YKFP goals are to increase natural production of and opportunity to harvest salmon and steelhead in the Yakima and Klickitat subbasins using hatchery supplementation, harvest augmentation and habitat improvements. Klickitat subbasin M&E activities have been subjected to scientific and technical review by members of the YKFP Science/Technical Advisory Committee (STAC) as part of the YKFP's overall M&E proposal. Yakama Nation YKFP biologists have transformed the conceptual design into the tasks described. YKFP biologists have also been involved with the Collaborative Systemwide Monitoring and Evaluation Project (CSMEP - a project aimed at improving the quality, consistency, and focus of fish population and habitat data to answer key M&E questions relevant to major decisions in the Columbia Basin) and are working towards keeping Klickitat M&E activities consistent with CSMEP recommendations. This report summarizes progress and results for the following major categories of YN-managed tasks under this contract: (1) Monitoring and Evaluation - to gather baseline information in order to characterize habitat and salmonid populations pre- and post-habitat restoration and pre-supplementation. (2) Ecological Interactions - to determine presence of pathogens in wild and naturally produced salmonids in the Klickitat Basin and develop supplementation strategies using this information. (3) Genetics - to develop YKFP supplementation broodstock collection

  19. MMP-13 In-Vivo Molecular Imaging Reveals Early Expression in Lung Adenocarcinoma.

    Directory of Open Access Journals (Sweden)

    Mathieu Salaün

    Full Text Available Several matrix metalloproteinases (MMPs are overexpressed in lung cancer and may serve as potential targets for the development of bioactivable probes for molecular imaging.To characterize and monitor the activity of MMPs during the progression of lung adenocarcinoma.K-rasLSL-G12D mice were imaged serially during the development of adenocarcinomas using fluorescence molecular tomography (FMT and a probe specific for MMP-2, -3, -9 and -13. Lung tumors were identified using FMT and MRI co-registration, and the probe concentration in each tumor was assessed at each time-point. The expression of Mmp2, -3, -9, -13 was quantified by qRT-PCR using RNA isolated from microdissected tumor cells. Immunohistochemical staining of overexpressed MMPs in animals was assessed on human lung tumors.In mice, 7 adenomas and 5 adenocarcinomas showed an increase in fluorescent signal on successive FMT scans, starting between weeks 4 and 8. qRT-PCR assays revealed significant overexpression of only Mmp-13 in mice lung tumors. In human tumors, a high MMP-13 immunostaining index was found in tumor cells from invasive lesions (24/27, but in none of the non-invasive (0/4 (p=0.001.MMP-13 is detected in early pulmonary invasive adenocarcinomas and may be a potential target for molecular imaging of lung cancer.

  20. Sustainable Seas Student Intertidal Monitoring Project at Duxbury Reef in Bolinas, CA

    Science.gov (United States)

    Rainsford, A.; Soave, K.; Gerraty, F.; Jung, G.; Quirke-Shattuck, M.; Kudler, J.; Hatfield, J.; Emunah, M.; Dean, A. F.

    2014-12-01

    The Sustainable Seas Student Monitoring Project at the Branson School in Ross, CA has monitored Duxbury Reef in Bolinas, CA since 1999, in cooperation with the Farallones Marine Sanctuary Association and the Gulf of Farallones National Marine Sanctuary. Goals of this student-run project include: 1) To monitor the rocky intertidal habitat and develop a baseline database of invertebrates and algal density and abundance; 2) To contribute to the conservation of the rocky intertidal habitat through education of students and visitors about intertidal species; 3) To increase stewardship in the Gulf of the Farallones National Marine Sanctuary; and 4) To contribute abundance and population data on key algae and invertebrate species to the national database, LiMPETS (Long Term Monitoring Program & Experiential Training for Students). Each fall student volunteers complete an intensive training course on the natural history of intertidal invertebrates and algae, identification of key species, rocky intertidal monitoring techniques, and history of the sanctuary. Students identify and count key invertebrate and algae species along two permanent transects and, using randomly determined points, within two permanent 200 m2 areas, in fall, winter, and late spring. Using data from the previous years, we will compare population densities, seasonal abundance and long-term population trends of key algal and invertebrate species, including Tegula funebralis, Anthopluera elegantissima, Cladophora sp. and Fucus sp.. Future analyses and investigations will include intertidal abiotic factors (including water temperature, pH and human foot-traffic) to enhance insights into the Duxbury Reef ecosystem, in particular, the high and mid-intertidal zones experiencing the greatest amount of human impacts.

  1. A guide to environmental monitoring data, 1945--1972: Hanford Environmental Dose Reconstruction Project

    Energy Technology Data Exchange (ETDEWEB)

    Thiede, M.E.; Bates, D.J.; Mart, E.I.; Hanf, R.W.

    1994-03-01

    This report is a guide to the work accomplished by the Environmental Monitoring Data Task, which is one of the tasks in the Hanford Environmental Dose Reconstruction (HEDR) Project. The objective of the Environmental Monitoring Data Task was to recover, evaluate, process, and/or reconstruct the environmental monitoring data for the period 1945--1972. The period of time for which environmental monitoring data were sought was determined by the start-up and shut-down dates of the Hanford facilities that emitted the majority of radionuclides to the two major pathways: air and the Columbia River. Radionuclide emissions to the air were mainly the result of the operation of the chemical separations plants from 1944--1972 (Heeb 1994). Radionuclide emissions to the Columbia River were mainly the result of the operation of the single-pass production reactors from 1944--1971 (Heeb and Bates 1994). Therefore, the historical environmental monitoring data sought were for the period 1945--1972. Within the period of 1945--1972, specific periods of interest to the HEDR Project vary depending on the pathway. For example, 1945--1951 was the peak period for radionuclide emissions to the air and hence vegetation uptake of radionuclides, while 1956--1965 was the peak period for radionuclide emissions to the Columbia River and hence fish uptake of radionuclides. However, adequate historical data were not always available for the periods of interest. In the case of vegetation measurements, conversion and correction factors had to be developed to convert the historical measurements to modern standard measurements. Table S.1 lists the reports that explain these conversion and correction factors. In the case of Columbia River fish and waterfowl, bioconcentration factors were developed for use in any year where the river pathway data are insufficient.

  2. MMP-2、MMP-3、MMP-9和 TIMP-1评价膝关节骨性关节炎的临床研究%The value of MMP-2,MMP-3,MMP-9 and TIMP-1 levels in the evaluation of knee joint osteoarthritis

    Institute of Scientific and Technical Information of China (English)

    贺占坤; 沈杰威

    2013-01-01

    目的:研究膝关节骨性关节炎(OA)患者关节液中基质金属蛋白酶(MMP)-2、MMP-3、MMP-9和基质金属蛋白酶抑制剂-1(T IM P-1)4种蛋白水平,并探讨其与关节损伤程度及患者预后的关系。方法52例患者均给予关节镜下清理术联合玻璃酸钠、双醋瑞因的治疗方法,于治疗前后采用 ELISA 检测52例膝关节 OA 患者及10例症状轻、X线等影像阴性者关节液中MMP-2、MMP-3、MMP-9和TIMP-1的含量并进行相关分析,并在关节镜下对膝关节软骨损伤程度进行评价。结果膝关节OA患者关节液中MMP-2、MMP-3、MMP-9和TIMP-1的含量均明显高于对照组(P<0.01)。关节液中MMP-2、MMP-3、MMP-9和TIMP-1的含量与关节软骨损伤程度呈正相关,随着病情的好转,关节液中MMP-2、MMP-3、MMP-9和TIMP-1的含量也随之降低。结论检测关节液中MMP-2、MMP-3、MMP-9和TIMP-1水平对膝关节OA的早期诊断、病情程度判断、预后评价有一定的意义。%Objective To explore the relationship between the level of matrix metallo-proteinase(MMP)-2 ,MMP-3 ,MMP-9 and matrix metallo-proteinase inhibitor-1(TIMP-1) in the synovial fluid of the patients with knee joint osteoarthritis (OA) and the de-gree of articular cartilage injury and prognosis .Methods 52 patients(knee OA group) were given arthroscopic debridement com-bined with sodium hyaluronate ,diacerein .The levels of MMP-2 ,MMP-3 ,MMP-9 and TIMP-1 in synovial fluid were detected in 52 patients with knee OA and 10 normal controls(control group) by enzyme-linked immunosorbent assay .The degree of cartilage inju-ry was assessed with arthroscopy .Results The level of MMP-2 ,MMP-3 ,MMP-9 and TIMP-1 in knee OA group were significantly higher than those of the control group(all P<0 .01) .The levels of MMP-2 ,MMP-3 ,MMP-9 and TIMP-1 in the synovial fluid were positively correlated with the degree of articular cartilage injury ,and the levels of MMP-2 ,MMP-3 ,MMP-9

  3. Relationship of MMP-2 and MMP-9 expression of SGC7901 with IL-8 in vitro%IL-8与胃癌细胞SGC7901MMP-2和MMP-9表达的关系

    Institute of Scientific and Technical Information of China (English)

    林晓; 王娅兰

    2005-01-01

    目的探讨趋化因子白介素-8(IL-8)与胃癌细胞SGC7901细胞胶原酶MMP-2和MMP-9表达的关系.方法体外细胞培养,MTT法及免疫组化方法检测细胞增殖率及MMP-2,MMP-9蛋白表达.结果 IL-8处理组SGC7901细胞MMP-2表达较对照组(无IL-8)比较,具有显著增强(P<0.05),而MMP-9无明显差异.结论 IL-8能促进细胞SGC7901 MMP-2表达,而对MMP-9无明显影响.

  4. Expression of matrix metalloproteinases (MMP-2 、MMP-9) in the pancreatic carcinoma%胰腺癌组织中MMP-2、MMP-9的表达

    Institute of Scientific and Technical Information of China (English)

    吴俊本; 张洁; 成丕光; 王树静; 巩本刚; 徐怀勇

    2012-01-01

    目的 检测胰腺癌组织基质金属蛋白酶( MMP-2,MMP-9)的表达,分析其与临床病理特征的关系.方法 应用免疫组化SP法检测30例胰腺癌及配对癌旁胰腺组织以及11例慢性胰腺炎、6例正常胰腺组织中MMP-2、MMP-9的表达,运用统计软件SPSS 12.0分析其与临床病理特征的相关性.结果 正常胰腺组织均无MMP-2及MMP-9的表达.慢性胰腺炎组织MMP-2、MMP-9的阳性表达率均为18.2% (2/11).胰腺癌组织MMP-2、MMP-9的阳性表达率分别为63.3% (19/30)和56.7% (17/30);配对癌旁组织的阳性表达率分别为23.3% (7/30)和40.0%( 12/30).胰腺癌组织的MMP-2及MMP-9阳性表达率均显著高于配对癌旁组织(P<0.05);胰腺癌组织及癌旁组织中MMP-2及MMP-9的表达均显著高于慢性胰腺炎组织和正常胰腺组织(P值均<0.05).MMP-2、MMP-9的表达与胰腺癌临床分期、肿瘤大小、分化程度及淋巴结转移相关.结论 胰腺癌组织中MMP-2、MMP-9呈高表达,其高表达与肿瘤的恶性程度相关.%Objective To study the expression of matrix metallopro-teinase-2 (MMP-2),matrix metalloproteinase-9 (MMP-9) in the pancreatic carcinomas. Methods MMP-2,MMP-9 expression were detected by immunohistochemistry in surgically resected specimens ( cancer tissues,cancer-adjacent tissues and normal tissues) from 30 PC patients,11 pancreatitis patients and 6 normal patients.the results were analyzed combined with clinical pathologic characteristics.The data was analyzed by Chi-Square test.Results There was no expression of MMP-2,MMP-9 in normal pancreatic tissues.Both of MMP-2 and MMP-9 expressions were 18.2% in chronic pancreatitis titssues.Expression of MMP-2,MMP-9 were higher in cancer tissues than in cancer-adjacent tissues(63.3% vs 23.3%,56.7% vs 40.0%,P <0.05).There were positive correlation between MMP-2,MMP-9 expression and lymph nodal metastasis,tumor sizes,clinical stage and differentiation of tumor(P <0.05).Conclusions

  5. Sustainable Seas Student Intertidal Monitoring Project at Duxbury Reef in Bolinas, CA (Invited)

    Science.gov (United States)

    Soave, K.; Dean, A.; Darakananda, K.; Ball, O.; Butti, C.; Yang, G.; Vetter, M.; Grimaldi, Z.

    2009-12-01

    Sustainable Seas Student Intertidal Monitoring Project at Duxbury Reef in Bolinas, CA Kathy Soave, Amy Dean, Olivia Ball, Karin Darakananda, Matt Vetter, Grant Yang, Charlotte Butti, Zoe Grimaldi The Sustainable Seas Student Monitoring Project at the Branson School in Ross, CA has monitored Duxbury Reef in Bolinas, CA since 1999, in cooperation with the Farallones Marine Sanctuary Association and the Gulf of Farallones National Marine Sanctuary. Goals of the project include: 1) To monitor the rocky intertidal habitat and develop a baseline database of invertebrates and algal density and abundance; 2) To contribute to the conservation of the rocky intertidal habitat through education of students and visitors about intertidal species and the requirements for maintaining a healthy, diverse intertidal ecosystem; 3) To increase stewardship in the Gulf of the Farallones National Marine Sanctuary; and 4) To contribute abundance and population data on key algae and invertebrate species to the national database, LiMPETS (Long Term Monitoring Program & Experiential Training for Students). Student volunteers complete an intensive training course on the natural history of intertidal invertebrates and algae, identification of key species, rocky intertidal monitoring techniques, and history of the sanctuary. Students identify and count key invertebrate and algae species along two permanent transects (A and B) and using randomly determined points within a permanent 100 m2 area, three times per year (fall, winter, and late spring). Using the data collected since 2004, we will analyze the population densities, seasonal abundance and long-term population trends of key algal and invertebrate species. Future analyses and investigations will include intertidal abiotic factors (including water temperature and human foot-traffic) to enhance insights into the workings of the Duxbury Reef ecosystem, in particular, the high intertidal zone which experiences the greatest amount of human

  6. Matrix metalloproteinase (MMP)-2 gene polymorphisms affect circulating MMP-2 levels in patients with migraine with aura.

    Science.gov (United States)

    Gonçalves, Flavia M; Martins-Oliveira, Alisson; Lacchini, Riccardo; Belo, Vanessa A; Speciali, Jose G; Dach, Fabíola; Tanus-Santos, Jose E

    2013-01-01

    Matrix metalloproteinases (MMP) are involved in the disruption of blood-brain barrier (BBB) during migraine attacks. In the present study, we hypothesized that two functional polymorphisms (C(-1306)T and C(-735)T) in MMP-2 gene and MMP-2 haplotypes are associated with migraine and modify MMP-2 and tissue inhibitor of MMP (TIMP)-2 levels in migraine. Genotypes for MMP-2 polymorphisms were determined by real time-PCR using Taqman allele discrimination assays. Haplotypes were inferred using the PHASE program. Plasma MMP-2 and TIMP-2 concentrations were measured by gelatin zymography and ELISA, respectively, in 148 healthy women without history of migraine and in 204 women with migraine (153 without aura; MWA, and 51 with aura; MA). Patients with MA had higher plasma MMP-2 concentrations and MMP-2/TIMP-2 ratios than patients with MWA and controls (P0.05), we found that the CC genotype for C(-735)T polymorphism and the CC haplotype were associated with higher plasma MMP-2 concentrations in MA group (P<0.05). Our findings may help to understand the role of MMP-2 and its genetic variants in the pathophysiology of migraine and to identify a particular group of migraine patients with increased MMP-2 levels that would benefit from the use of MMP inhibitors.

  7. Prognostic values of ETS-1, MMP-2 and MMP-9 expression and co-expression in breast cancer patients.

    Science.gov (United States)

    Puzovic, V; Brcic, I; Ranogajec, I; Jakic-Razumovic, J

    2014-01-01

    The aim of this study was to analyse expression of ETS-1 protein and two gelatinases (MMP-2 and MMP-9) and their possible prognostic value in breast carcinoma patients, as well as correlation of their expression with other known prognostic factors such as tumor size, grade, vascular invasion, steroid receptor values, HER2 values and proliferative index. The expression of MMP-2, MMP-9 and ETS-1 was immunohistochemicaly analysed in 121 consecutive primary breast carcinoma patients who underwent surgery at the Clinical Hospital Centre Zagreb during 2002. Three representative areas from each tumor paraffin blocks were taken and arranged on a recipient paraffin block with predefined coordinates for simultaneous analyses of multiple tissue samples (TMA). ETS-1, MMP-2 and MMP-9 expression and co-expression were correlated with other clinico-pathological parameters and based on the available clinical follow up data survival analysis was performed. The ETS-1 protein is found to be expressed in tumor cell nuclei and cytoplasm as well as in stromal lymphocytes, fibroblasts and endothelial cells. MMP-2 and MMP-9 were found to be expressed in cytoplasm of both, tumor and stromal cells. For our analysis only tumor cell expression was used for statistical analysis. We found 56,2% ETS-1 positive tumors, 77,7% were MMP-2 positive, and MMP-9 was expressed in 90% of primary breast carcinomas. There were no significant correlations between MMP-s expression and other patohistological prognostic factors, but expression of ETS-1 was significantly correlated with higher tumor size and grade, as well as with negative steroid receptors. Co-expression of MMP-2, MMP-9 and ETS-1 was found in 40,5 % of tumors, and more commonly was found in tumors larger than 2 cm, high grade tumors, and steroid receptor negative tumors. In univariate analysis, statistically significant negative impact on overall survival (OS) had tumor size, nuclear and tumor grade, ETS-1 expression in tumor cells, co

  8. Expression and significance of oral lichen planus in MMP-2 and MMP-9%口腔扁平苔藓中MMP-2和MMP-9的表达及意义

    Institute of Scientific and Technical Information of China (English)

    浦光瑞; 张虹

    2012-01-01

    [目的]探索MMP -2和MMP -9与口腔扁平苔藓(oral lichen planus,OLP)的发生、发展乃至癌变潜能的关系.[方法]采用免疫组化SP法检测MMP -2和MMP -9在22例OLP、11例正常口腔黏膜组织、22例白斑和22例口腔鳞癌组织表达.[结果]在正常口腔黏膜、扁平苔藓、白斑和鳞癌组织中MMP -2和MMP -9的表达依次增加.MMP -2和MMP -9在口腔扁平苔藓和白斑中的表达显著高于正常口腔黏膜(P<0.05),但在口腔扁平苔藓和白斑间的表达差异无显著性意义(P>0.05);在鳞癌中的表达显著高于其他3组(P<0.05).[结论] MMP -2和MMP -9表达与OLP的发生、发展乃至癌变潜能有关.%To Explore the relationshiops of MMP -2 and MMP -9 to the OLP occurrence, the development and even the canceration potential. [Methods] Immunohisto ?chemistry was performed to examine expressions of MMP -2 and MMP -9 in 22 OLP, 11 normal oral mucosa, 22 oral leukoplakia and 22 squamous cell carcinoma. [Results] The expression of MMP -2 and MMP -9 increased in turn from normal oral mucosa to OLP, oral leukoplakia and oral squamous cell carcinoma tissues. The expression of MMP -2 and MMP -9 in OLP and oral leukoplakia was significantly higher than that in normal oral mucosa ( P 0. 05) ; The expression of MMP - 2 and MMP - 9 in squamous cell carcinoma was significantly higher than The other three groups (P < 0. 05 ) , there was significant difference. [ Conclusion ] The expression levels of MMP - 2 and MMP - 9 correlate with the occurrence of oral lichen planus, development and e-ven cancer potential, which may be useful indicator to judge the possibility of malignant change of OLP.

  9. Miniaturized, Multi-Analyte Sensor Array for the Automated Monitoring of Major Atmospheric Constituents in Spacecraft Environment Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of the Phase II SBIR project is to develop a prototype sensor system to detect gaseous analytes in support of the spacecraft environmental monitoring...

  10. Expression of MMP-2,MMP-14 and TIMP-2 in Gastric Cancer and Its Clinical Significance%MMP-2、MMP-14、TIMP-2在胃癌组织中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    张金玲; 费雁; 陈伟; 冯刚

    2013-01-01

    Objective To examine the expression of MMP-2, MMP-14 and TIMP-2 in gastric cancer and its clinical significance. Methods The expression of MMP-2,MMP-14 and TIMP-2 was immunohistochemically detected in 80 samples of gastric cancer tissues and 30 adjacent normal gastric tissues. Results The positive expression rate of MMP-2 and MMP-14 was 75.00% and 82. 50% respectively,in gastric cancer tissues,significantly higher than that in normal gastric tissues(36. 67% and 33. 33% ,respectively) (P<0. 01). The positive expression rate of TIMP-2 was 45. 00% and 40. 00% in gastric cancer tissues and normal gastric tissues with no significant difference being found. The expression of MMP-2 and MMP-14 in gastric cancer tissues was closely correlated to the cell differentiation,invasion,lymph node metastasis and TNM stages(P<0. 01). But the expression of TIMP-2 in gastric cancer tissues was only related to the lymph node metastasis (P<0. 05). The expression levels of MMP-2 and MMP-14 were significantly higher in survival time <2 years group than in survival time ≥2 years group(P<0. 01). Conclusion MMP-2 and MMP-14 are over-expressed in gastric cancer. Combined detection for MMP-2/MMP-14 or MMP-2/MMP-14/TIMP-2 may help evaluate the malignancy of gastric cancer and predict the prognosis of patients with gastric cancer.%目的 探讨基质金属蛋白酶(matrix metalloproteinase,MMP)-2、14及基质金属蛋白酶组织抑制因子-2(tissue inhibitor of metalloproteinase,TIMP-2)在胃癌中的表达及其意义.方法 用免疫组织化学方法 (SP法)检测80例胃癌手术患者胃癌组织及30例同期癌旁≥5 cm正常组织中MMP-2、MMP-14及TIMP-2的表达.结果 ①在胃癌、正常胃组织中,MMP-2阳性表达率分别为75.00%和36.67%,MMP-14阳性表达率分别为82.50%和33.33%,差异有统计学意义(均P<0.01);TIMP-2阳性表达率分别为45.00%和40.00%,差异无统计学意义.②癌组织中,MMP-2、MMP-14的表达与肿瘤分化程度、浸润深度、

  11. [Monitoring populations of rodent reservoirs of zoonotic diseases. Projects, aims and results].

    Science.gov (United States)

    Jacob, J; Ulrich, R G; Freise, J; Schmolz, E

    2014-05-01

    Rodents can harbor and transmit pathogens that can cause severe disease in humans, companion animals and livestock. Such zoonotic pathogens comprise more than two thirds of the currently known human pathogens. The epidemiology of some zoonotic pathogens, such as hantaviruses, can be linked to the population dynamics of the rodent host. In this case, during an outbreak of the rodent host population many human infections may occur. In other rodent-borne zoonotic diseases such phenomena are not known and in many cases the rodent host specificity of a given pathogen is unclear. The monitoring of relevant rodent populations and of the rodent-borne zoonotic pathogens is essential to (1) understand the distribution and epidemiology of pathogens and (2) develop forecasting tools to predict outbreaks of zoonoses. Presently, there are no systematic long-term monitoring programs in place for zoonoses in Germany. Rodent monitoring activities are largely restricted to the plant protection sector, such as for the common vole (Microtus arvalis) and forest-damaging rodents. However, during the last 10-15 years a number of specific research projects have been initiated and run for a few years and Norway rat (Rattus norvegicus) monitoring has been implemented in Hamburg and Lower Saxony. Based on close cooperation of federal and state authorities and research institutions these efforts could be utilized to gain information about the distribution and importance of rodent-borne zoonoses. Nevertheless, for the integration of rodent population dynamics and zoonotic disease patterns and especially for developing predictive models, long-term monitoring is urgently required. To establish a systematic long-term monitoring program, existing networks and cooperation need to be used, additional collaborators (e.g., pest control operators) should be included and synergetic effects of different scientific fields should be utilized.

  12. Angiogenesis in vestibular schwannomas: expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1

    DEFF Research Database (Denmark)

    Møller, Martin Nue; Werther, Kim; Nalla, Amarnadh;

    2010-01-01

    Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are potent mediators of tumor angiogenesis. It has been demonstrated that vestibular schwannoma VEGF expression correlates with tumor growth pattern, whereas knowledge on the expression of MMPs is lacking. This study t...... targets the angiogenic process by investigation of tumor expression of MMP-2, MMP-9, and tissue inhibitors of metalloproteinase (TIMP)-1. A possible correlation with gender, patient age, symptom duration, tumor size, and the absolute and relative growth rate is explored....

  13. Endothelium specific matrilysin (MMP-7) expression in human cancers

    NARCIS (Netherlands)

    Sier, C.F.M.; Hawinkels, L.J.A.C.; Zijlmans, H.J.M.A.A.; Zuidwijk, K.; Jonge de; Muller, E.S.M.; Ferreira, V.; Hanemaaijer, R.; Mulder-Stapel, A.A.; Kenter, G.G.; Verspaget, H.W.; Gorter, A.

    2008-01-01

    Over-expression of matrilysin (MMP-7) is predominantly associated with epithelial (pre)malignant cells. In the present study MMP-7 expression is also found in endothelial cells in various human cancer types. Endothelial MMP-7 was associated with CD34 and/or CD105 expression. These immunohistochemica

  14. VEGF、MMP-2与MMP-9在卵巢癌组织中的表达及其临床意义%Expression and clinical significance of VEGF,MMP-2 and MMP-9 in ovarian carcinoma

    Institute of Scientific and Technical Information of China (English)

    曾晓林; 彭耀金

    2010-01-01

    目的:探讨VEGF、MMP-2和MMP-9在卵巢癌组织中的表达及其与卵巢癌发生发展的关系.方法:采用免疫组织化学法检测VEGF、MMP-2和MMP-9在正常卵巢组织、卵巢癌组织中的表达,并对三者的相关性进行分析.结果:卵巢癌组织中VEGF、MMP-2和MMP-9蛋白的表达阳性率显著高于正常卵巢组织(P<0.05),且在卵巢癌Ⅲ~Ⅳ期患者标本中阳性率高于Ⅰ~Ⅱ期(P<0.05);VEGF、MMP-2和MMP-9蛋白阳性表达率与卵巢癌临床分期和淋巴结转移有关(P<0.05).结论:正常卵巢组织和卵巢癌组织中VEGF、MMP-2和MMP-9蛋白含量的变化一致;VEGF、MMP-2和MMP-9均参与了卵巢癌的发生发展过程,三者间可能有协同作用.

  15. An Investigation of Structural Capacity as a Component of Monitoring and Evaluation in Project Success of Road Construction Projects in Kenya

    Directory of Open Access Journals (Sweden)

    Ali Ibrahim Hassan

    2013-08-01

    Full Text Available The transport sector in Kenya contributes about 6% of the gross domestic product and is critical in providing the necessary linkages for promoting national and regional interconnectivity as well as trade. Developments in the road construction industry in Kenya are increasing in size, technology complexity, interdependencies, and variations in demands from clients. Enormous donor and government resources are provided to various road contractors for the construction of road projects in Kenya.Monitoring and evaluation of road projects implementation is paramount in determining the success of road construction projects. It is hypothesized that poor and inefficient monitoring and evaluation of road construction projects could be one of the causes of endemic project delays and poor workmanships on completed road projects. It was therefore imperative to examine the monitoring and evaluation systems used in road construction projects in Kenya, and assess their effectiveness, with a particular emphasis on the components of monitoring and evaluation system. The objective of this study was therefore to assess the influence of monitoring and evaluation system on project success. The target population of this study was the road contractors and regulatory bodies involved in ongoing road construction projects in Nairobi city and its environs. A descriptive study design was used to collect quantitative and qualitative data. Primary data was collected by use of structured questionnaires. The questionnaire was designed to respond to research question. Secondary data was collected through review of published literature such as journal articles, published theses and textbooks. The data collected from the field was captured using Statistical Package for Social Sciences (SPSS and Microsoft excel. Descriptive statistics including frequency, percentages and means were employed and a summary graphs, pie charts and frequency distribution tables given. Content analysis

  16. A Web-Based System for Monitoring and Controlling Multidisciplinary Design Projects

    Science.gov (United States)

    Salas, Andrea O.; Rogers, James L.

    1997-01-01

    In today's competitive environment, both industry and government agencies are under enormous pressure to reduce the time and cost of multidisciplinary design projects. A number of frameworks have been introduced to assist in this process by facilitating the integration of and communication among diverse disciplinary codes. An examination of current frameworks reveals weaknesses in various areas such as sequencing, displaying, monitoring, and controlling the design process. The objective of this research is to explore how Web technology, in conjunction with an existing framework, can improve these areas of weakness. This paper describes a system that executes a sequence of programs, monitors and controls the design process through a Web-based interface, and visualizes intermediate and final results through the use of Java(Tm) applets. A small sample problem, which includes nine processes with two analysis programs that are coupled to an optimizer, is used to demonstrate the feasibility of this approach.

  17. Monitoring and Evaluation of Environmental Flow Prescriptions for Five Demonstration Sites of the Sustainable Rivers Project

    Science.gov (United States)

    Konrad, Christopher P.

    2010-01-01

    The Nature Conservancy has been working with U.S. Army Corps of Engineers (Corps) through the Sustainable Rivers Project (SRP) to modify operations of dams to achieve ecological objectives in addition to meeting the authorized purposes of the dams. Modifications to dam operations are specified in terms of environmental flow prescriptions that quantify the magnitude, duration, frequency, and seasonal timing of releases to achieve specific ecological outcomes. Outcomes of environmental flow prescriptions implemented from 2002 to 2008 have been monitored and evaluated at demonstration sites in five rivers: Green River, Kentucky; Savannah River, Georgia/South Carolina; Bill Williams River, Arizona; Big Cypress Creek, Texas; and Middle Fork Willamette River, Oregon. Monitoring and evaluation have been accomplished through collaborative partnerships of federal and state agencies, universities, and nongovernmental organizations.

  18. 2009 Groundwater Monitoring Report Project Shoal Area, Corrective Action Unit 447

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-03-01

    This report presents the 2009 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) at the Project Shoal Area (PSA) Subsurface Corrective Action Unit (CAU) 447 in Churchill County, Nevada. Responsibility for the environmental site restoration of the PSA was transferred from the DOE Office of Environmental Management to LM on October 1, 2006. The environmental restoration process and corrective action strategy for CAU 447 are conducted in accordance with the Federal Facility Agreement and Consent Order (FFACO 1996, as amended February 2008) entered into by DOE, the U.S. Department of Defense, and the State of Nevada. The corrective action strategy for the site includes monitoring in support of site closure. This report summarizes investigation activities associated with CAU 447 that were conducted at the PSA during fiscal year 2009.

  19. Relationship Between Unstable Angina Pectoris CHD and MMP-1, MMP-2 and MMP-3%冠心病不稳定型心绞痛与MMP-1、MMP-2、MMP-3相关性研究

    Institute of Scientific and Technical Information of China (English)

    王莹威; 蒋宁; 高嵩山; 魏明慧

    2013-01-01

    目的:研究冠心病不稳定型心绞痛(UA)患者血清MMP-1、MMP-2、MMP-3的表达,并探讨其与冠状动脉狭窄程度和斑块不稳定性之间的关系.方法:分离出30例UA和30例CPS患者血清,采用酶联免疫吸附法(ELISA)检测其中的MMP-1、MMP-2、MMP-3表达水平,并进行相关性研究.结果:UA和CPS组患者血清中MMP-1、MMP-2、MMP-3有统计学意义(P<0.005).结论:冠心病不稳定型心绞痛患者血清中MMP-1、MMP-2、MMP-3表达水平增高,提示其可能是动脉粥样硬化不稳定斑块的发病机制之一.%Objective:To investigate patients with unstable angina(UA) serum expressions of MMP-1,MMP-2 and M MP-3,and explore the relationship between the coronary stenosis and plaque instability.Methods:The serum from 30 patients with UA and 30 patients with CPS was isolated in which MMP-1,MMP-2,MMP-3 expression levels were tested by enzyme-linked immunosorbent assay (ELISA),and related research was carried on.Results:UA and CPS groups' MMP-1,MMP-2,MMP-3 expressions had statistical significance(P < 0.005).Conclusion:The serum expression levels of MMP-1,MMP-2 and MMP -3 in coronary heart disease patients with unstable angina were increased,suggesting that it may be one of the unstable plaque pathogenesis of atherosclerosis.

  20. IEA GHG Weyburn CO{sub 2} monitoring and storage project : summary report 2000-2004

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, M. (ed.) [Regina Univ., SK (Canada); Monea, M. (ed.) [Petroleum Technology Research Centre, Regina, SK (Canada); Whittaker, S. [Saskatchewan Industry and Resources, Regina, SK (Canada); White, D. [Geological Survey of Canada, Ottawa, ON (Canada); Law, D. [Alberta Research Council, Edmonton, AB (Canada); Chalaturnyk, R. [Alberta Univ., Edmonton, AB (Canada)

    2004-07-01

    The Weyburn CO{sub 2} Monitoring and Storage Project is a multi-million dollar Canadian research project launched in July 2000 to determine the feasibility of geological storage of carbon dioxide (CO{sub 2}) at EnCana's enhanced oil recovery project at its Weyburn Unit in Saskatchewan. This book reviews the operating status of the project and provides a new understanding of the geological storage of greenhouse gases, particularly carbon dioxide. The project aims to predict and verify the ability of an oil reservoir to securely and economically store CO{sub 2}. Various mechanisms for geological storage were examined along with the degree to which CO{sub 2} can be permanently stored in geological formations. The Weyburn field has been subjected to waterflooding since 1964 and extensive use of horizontal wells since 1991. The first phase of the CO{sub 2} enhanced oil recovery scheme began in September 2000 in 18 inverted 9-spot patterns. The flood will be expanded over the next 15 years to a total of 75 patterns. A total of 20 million tonnes of CO{sub 2} is expected to be injected into the reservoir over the life of the project. The CO{sub 2} is a purchased by-product from the Dakota Gasification Company's synthetic fuel plant in Beulah, North Dakota. The carbon dioxide is transported via a 320 km pipeline to Weyburn. The project has been monitored and evaluated since its launch. This study involved an assessment of geochemical reactions from the action of CO{sub 2} on reservoir rock and the impact that it might have on geomechanical integrity and CO{sub 2} sequestration. A geoscience model of the storage medium was developed to identify potential migration pathways for CO{sub 2}. Risk assessments were conducted to predict long-term fate of CO{sub 2} within the storage sites. An economic model was also developed to define the limits of economic storage during and after enhanced oil recovery operations. refs., tabs., figs.

  1. Project GeoWSN: High precision but low-cost GNSS landslide monitoring in Austria

    Science.gov (United States)

    Koch, Daniel; Brandstätter, Michael; Kühtreiber, Norbert

    2014-05-01

    At present, GNSS monitoring of landslides is an accepted and approved method to detect movements of slopes at risk in the sub-centimetre level. However, high-precision geodetic GNSS-receivers are expensive, therefore this monitoring method is not widely applied. Recently low-cost GNSS-receivers are conquering the geodetic market and are well suited for a cost effective and yet precise GNSS-monitoring. During the project GeoWSN, which was funded by the Austrian Research Promotion Agency (FFG), an applicable low-cost monitoring system was developed at Graz University of Technology. The system is based on a so-called Wireless Sensor Network (WSN) consisting of low-cost GNSS-receivers, temperature and humidity sensors and inertial measurement units. Additionally energy-harvesting technologies and power-saving algorithms provide that the system is energy- autarkic. For real-time applications, a communication link between the sensor nodes is implemented. The relative positioning method RTK (Real Time Kinematic) is applied to reach the highest possible accuracy. The GeoWSN sensor nodes enable the detection of possible movements in the real-time processed positions of the sensor nodes. To ensure a real-time evaluation and interpretation of the data, the current status of the slope can be acquired by a local warning centre. Therefore, affected people can be warned within a short latency. Several test-scenarios have shown the acceptance of the system at the warning centre of Styria, Austria. This contribution should give an overview of the main idea of a low-cost warning system and results of the project GeoWSN.

  2. The AAL project: automated monitoring and intelligent analysis for the ATLAS data taking infrastructure

    Science.gov (United States)

    Kazarov, A.; Lehmann Miotto, G.; Magnoni, L.

    2012-06-01

    The Trigger and Data Acquisition (TDAQ) system of the ATLAS experiment at CERN is the infrastructure responsible for collecting and transferring ATLAS experimental data from detectors to the mass storage system. It relies on a large, distributed computing environment, including thousands of computing nodes with thousands of application running concurrently. In such a complex environment, information analysis is fundamental for controlling applications behavior, error reporting and operational monitoring. During data taking runs, streams of messages sent by applications via the message reporting system together with data published from applications via information services are the main sources of knowledge about correctness of running operations. The flow of data produced (with an average rate of O(1-10KHz)) is constantly monitored by experts to detect problem or misbehavior. This requires strong competence and experience in understanding and discovering problems and root causes, and often the meaningful information is not in the single message or update, but in the aggregated behavior in a certain time-line. The AAL project is meant at reducing the man power needs and at assuring a constant high quality of problem detection by automating most of the monitoring tasks and providing real-time correlation of data-taking and system metrics. This project combines technologies coming from different disciplines, in particular it leverages on an Event Driven Architecture to unify the flow of data from the ATLAS infrastructure, on a Complex Event Processing (CEP) engine for correlation of events and on a message oriented architecture for components integration. The project is composed of 2 main components: a core processing engine, responsible for correlation of events through expert-defined queries and a web based front-end to present real-time information and interact with the system. All components works in a loose-coupled event based architecture, with a message broker

  3. Power Monitoring and Control for Large Scale projects: SKA, a case study

    CERN Document Server

    Barbosa, Domingos; Maia, Dalmiro; Carvalho, Bruno; Vieira, Jorge; Swart, Paul; Roux, Gerhard Le; Natarajan, Swaminathan; van Ardenne, Arnold; Seca, Luis

    2016-01-01

    Large sensor-based science infrastructures for radio astronomy like the SKA will be among the most intensive data-driven projects in the world, facing very high demanding computation, storage, management, and above all power demands. The geographically wide distribution of the SKA and and its associated processing requirements in the form of tailored High Performance Computing (HPC) facilities, require a Greener approach towards the Information and Communications Technologies (ICT) adopted for the data processing to enable operational compliance to potentially strict power budgets. Addressing the reduction of electricity costs, improve system power monitoring and the generation and management of electricity at system level is paramount to avoid future inefficiencies and higher costs and enable fulfillments of Key Science Cases. Here we outline major characteristics and innovation approaches to address power efficiency and long-term power sustainability for radio astronomy projects, focusing on Green ICT for s...

  4. Environmental monitoring for the DOE coolside and LIMB demonstration extension projects

    Energy Technology Data Exchange (ETDEWEB)

    White, T.; Contos, L.; Adams, L. (Radian Corp., Research Triangle Park, NC (United States))

    1992-03-01

    The purpose of this document is to present environmental monitoring data collected during the US Department of Energy Limestone Injection Multistage Burner (DOE LIMB) Demonstration Project Extension at the Ohio Edison Edgewater Generating Station in Lorain, Ohio. The DOE project is an extension of the US Environmental Protection Agency's (EPA's) original LIMB Demonstration. The program is operated nuclear DOE's Clean Coal Technology Program of emerging clean coal technologies'' under the categories of in boiler control of oxides of sulfur and nitrogen'' as well as post-combustion clean-up.'' The objective of the LIMB program is to demonstrate the sulfur dioxide (SO{sub 2}) and nitrogen oxide (NO{sub x}) emission reduction capabilities of the LIMB system. The LIMB system is a retrofit technology to be used for existing coal-fired boilers equipped with electrostatic precipitators (ESPs).

  5. Floristic Quality Index: An assessment tool for restoration projects and monitoring sites in coastal Louisiana

    Science.gov (United States)

    Cretini, K.F.; Steyer, G.D.

    2011-01-01

    The Coastwide Reference Monitoring System (CRMS) program was established to assess the effectiveness of individual coastal restoration projects and the cumulative effects of multiple projects at regional and coastwide scales. In order to make these assessments, analytical teams have been assembled for each of the primary data types sampled under the CRMS program, including vegetation, hydrology, landscape, and soils. These teams consist of scientists and support staff from the U.S. Geological Survey and other Federal agencies, the Louisiana Office of Coastal Protection and Restoration, and university academics. Each team is responsible for developing or identifying parameters, indices, or tools that can be used to assess coastal wetlands at various scales. The CRMS Vegetation Analytical Team has developed a Floristic Quality Index for coastal Louisiana to determine the quality of a wetland based on its plant species composition and abundance.

  6. Seismic monitoring and analysis of deep geothermal projects in St Gallen and Basel, Switzerland

    Science.gov (United States)

    Edwards, Benjamin; Kraft, Toni; Cauzzi, Carlo; Kästli, Philipp; Wiemer, Stefan

    2015-05-01

    Monitoring and understanding induced seismicity is critical in order to estimate and mitigate seismic risk related to numerous existing and emerging techniques for natural resource exploitation in the shallow-crust. State of the art approaches for guiding decision making, such as traffic light systems, rely heavily on data such as earthquake location and magnitude that are provided to them. In this context we document the monitoring of a deep geothermal energy project in St Gallen, Switzerland. We focus on the issues of earthquake magnitude, ground motion and macroseismic intensity which are important components of the seismic hazard associated to the project. We highlight the problems with attenuation corrections for magnitude estimation and site amplification that were observed when trying to apply practices used for monitoring regional seismicity to a small-scale monitoring network. Relying on the almost constant source-station distance for events in the geothermal `seismic cloud' we developed a simple procedure, calibrated using several ML > 1.3 events, which allowed the unbiased calculation of ML using only stations of the local monitoring network. The approach determines station specific ML correction terms that account for both the bias of the attenuation correction in the near field and amplification at the site. Since the smallest events (ML computed over the whole network this single station approach was shown to provide robust estimates (±0.17 units) for the events down to ML = -1. The relation could then be used to estimate the magnitude of even smaller events (ML specific ML corrections due to local amplification. We analysed ground-motion and detailed macroseismic reports resulting from the 2013 July 20 St Gallen ML = 3.5 ± 0.1 (Mw = 3.3-3.5 ± 0.1) `main shock' and compared it to a similar ML = 3.4 ± 0.1 event (Mw = 3.2 ± 0.1) that occurred in 2006 at another deep geothermal project in Basel, Switzerland. Differences in ground motion amplitudes

  7. Serum IL-10, MMP-7, MMP-9 Levels in Helicobacter pylori Infection and Correlation with Degree of Gastritis

    OpenAIRE

    Gontar Siregar; Sahat Halim; Ricky Sitepu

    2016-01-01

    AIM: Helicobacter pylori causes gastric mucosal inflammation and immune reaction. However, the increase of IL-10, MMP-7, and MMP-7 levels in the serum is still controversial. The objective of this study was to investigate the serum levels of IL-10, MMP-7 & MMP-9 in gastritis patients with H. pylori infection. MATERIALS AND METHODS: A cross-sectional study was done on seventy gastritis patients that consecutive admitted to endoscopy units. The diagnosis of gastritis was made based on histo...

  8. Serum IL-10, MMP-7, MMP-9 Levels in Helicobacter pylori Infection and Correlation with Degree of Gastritis

    OpenAIRE

    Siregar, Gontar; Halim, Sahat; Sitepu, Ricky

    2016-01-01

    AIM: Helicobacter pylori causes gastric mucosal inflammation and immune reaction. However, the increase of IL-10, MMP-7, and MMP-7 levels in the serum is still controversial. The objective of this study was to investigate the serum levels of IL-10, MMP-7 & MMP-9 in gastritis patients with H. pylori infection.MATERIALS AND METHODS: A cross-sectional study was done on seventy gastritis patients that consecutive admitted to endoscopy units. The diagnosis of gastritis was made based on histopatho...

  9. Expressions of MMP-2-PEX and MMP-2 in invasive pituitary adenomas and its significance%MMP-2-PEX与MMP-2在侵袭性垂体腺瘤中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    屈洪涛; 杨伊林; 王穗暖; 刘运生; 王强; 董博; 毛宇敏

    2013-01-01

    Objective To investigate the expressions of matrix metalloproteinase-2 hemopexin domain (MMP-2-PEX) and matrix metalloproteinase-2 (MMP-2) in invasive pituitary adenomas and non-invasive pituitary adenomas, and to evaluate the relationship between the expressions of MMP-2-PEX and MMP-2 and the invasion of pituitary adenomas. Methods The expressions of MMP-2-PEX and MMP-2 mRNA were examined by reverse transcription-polymerse chain reaction assay. The relation between MMP-2-PEX and MMP-2, and the correlation between expression of MMP-2-PEX, MMP-2 and invasiveness of pituitary adenomas were studied. Results The expression of MMP-2-PEX mRNA in invasive pituitary adenomas was significantly lower than that of non-invasive pituitary adenomas (P < 0.01). The expression of MMP-2 mRNA in invasive pituitary adenomas was significantly higher than that of non-invasive pituitary adenomas (P<0.01). mRNA level of MMP-2-PEX was negatively related with mRNA of MMP-2 , and there was no correlation between them in non-invasive pituitary adenomas. Conclusion Low level of MMP-2-PEX is closely related with high level of MMP-2, so MMP-2-PEX and MMP-2 can be used as an important index for the evaluation of invasiveness of pituitary adenoma.%目的 研究基质金属蛋白酶-2在C端的血红素样结构域(MMP-2-PEX)和基质金属蛋白酶-2(MMP-2)在侵袭性垂体腺瘤中的表达及其意义.方法 用逆转录酶-聚合酶链反应(RT-PCR)法检测116例垂体腺瘤标本的MMP-2-PEX及MMP-2的表达,分析其与侵袭性垂体腺瘤的关系及两者之间的相关性.结果 侵袭性垂体腺瘤组MMP-2-PEX mRNA表达较非侵袭性垂体腺瘤组显著降低(P<0.01).侵袭性垂体腺瘤组的MMP-2 mRNA表达明显高于非侵袭性垂体腺瘤组(P<0.01).侵袭性垂体腺瘤组中MMP-2-PEX mRNA表达与MMP-2 mRNA表达呈负相关(r=-0.66,P<0.05),而非侵袭性腺垂体腺瘤组中无相关性(r =-0.22,P>0.05).结论 MMP-2-PEX低表达及MMP-2高表达与垂体腺瘤的侵袭性密切相关,MMP

  10. Expressions and correlations of MMP-1, MMP-7 with pathologic pattern in Hazak esophageal cancer patients%哈萨克族食管癌MMP-1与MMP-7表达及相关性

    Institute of Scientific and Technical Information of China (English)

    陈艳; 王洪江; 李卉; 庞作良; 李秀梅; 李惠武

    2012-01-01

    Objective To explore the expressions of metrix metalloproteinase-1 ( MMP-1) and metrix metalloprotein-ase-7(MMP-7) in esophageal cancer tissue and normal tissue,and to analyze their relationship with clinicopathological features among Hazak esophageal cancer patients. Methods The expression of MMP-1 and MMP-7 in cancer tissue and normal tissue of 45 esophageal cancer patients were detected with reverse transcription-PCR( RT-PCR). Results The positive rates of MMP-1 and MMP-7 mRNA in cancer tissues were 75.56% and 73. 33% ,and the positive rates of MMP-1 and MMP-7 mRNA in distal normal tissues were 15.56% and 31.11% .respectively. There were significant differences in MMP-1 and MMP-5 levels between cancer tissue and corresponding distal normal tissue(P <0.05). The expression of MMP-1 was related to tumor,node,metastasis(TNM) classification,while the expression of MMP-7 was correlated with lymph nodes metastasis and TNM stage (P <0. 05). Positive correlation was observed between the expression of MMP-1 and MMP-7(P<0.05). Conclusion The expressions of MMP-1 and MMP-7 play an important role in carcinogenesis of esophageal cancer among Hazak people. The combined actions of MMP-1 and MMP-7 may promote development of esophageal cancer.%目的 探讨基质金属蛋白酶1(MMP-1)、基质金属蛋白酶7(MMP-7)基因在哈萨克族食管癌和正常组织的表达及与病理特征关系,分析两者表达的相关性.方法 采用逆转录聚合酶链反应(RT-PCR)方法在45例哈萨克族食管癌癌组织及其远端正常组织中检测MMP-1与MMP-7基因的表达.结果 在45例食管癌组织中,MMP-1、MMP-7基因的表达阳性率分别为75.56%和73.33%,在远端正常组织的表达阳性率分别为15.56%和31.11%,二者差异均有统计学意义(P<0.05);MMP-1表达与TNM分期有关,MMP-7表达与TNM分期及淋巴结转移有关(P<0.05);MMP-1与MMP-7基因的表达具有正相关性(P<0.05).结论 MMP-1和MMP-7在哈萨克族食管癌发生

  11. Role of MMP-3 and MMP-9 and their haplotypes in risk of bladder cancer in North Indian cohort.

    Science.gov (United States)

    Srivastava, Priyanka; Mandhani, Anil; Kapoor, Rakesh; Mittal, Rama D

    2010-11-01

    Matrix metalloproteinases (MMPs) play critical roles in cancer development and progression. Nonsynonymous single nucleotide polymorphisms (SNPs) in functional domain of MMP-3 and MMP-9 contribute appreciably to cancer predisposition and aggression. To test this proposition we examined whether six SNPs of the MMP-3 and MMP-9 genes are associated with risk of bladder cancer (BC) in a North Indian population. Six SNPs of MMP-3 and MMP-9 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in a case-control study including 200 BC patients and 200 age/gender/ethnicity-matched controls. Increased risk for BC susceptibility was observed in MMP-3 (1171) 5A/5A [P = 0.022; odds ratio (OR), 3.46; 95% confidence interval (CI), 1.20-9.98], MMP-9 (Q279R) QQ (P = 0.048; OR, 1.92; 95%CI, 1.01-3.66), MMP-9 (P574R) PR (P BCG)-treated non-muscle-invasive BC (NMIBC) patients (log-rank P = 0.025). Our data suggested that MMP-3-1171 5A/5A and MMP-9 (Q279R) QQ, MMP-9 (P574R) PR, PR + RR, and R allele are associated with high risk of BC.

  12. Zymographic patterns of MMP-2 and MMP-9 in the CSF and cerebellum of dogs with subacute distemper leukoencephalitis.

    Science.gov (United States)

    Machado, Gisele F; Melo, Guilherme D; Souza, Milena S; Machado, Andressa A; Migliolo, Daniela S; Moraes, Olívia C; Nunes, Cáris M; Ribeiro, Erica S

    2013-07-15

    Distemper leukoencephalitis is a disease caused by the canine distemper virus (CDV) infection. It is a demyelinating disease affecting mainly the white matter of the cerebellum and areas adjacent to the fourth ventricle; the enzymes of the matrix metalloproteinases (MMPs) group, especially MMP-2 and MMP-9 have a key role in the myelin basic protein fragmentation and in demyelination, as well as in leukocyte traffic into the nervous milieu. To evaluate the involvement of MMPs during subacute distemper leukoencephalitis, we measured the levels of MMP-2 and MMP-9 by zymography in the cerebrospinal fluid (CSF) and in the cerebellum of 14 dogs naturally infected with CDV and 10 uninfected dogs. The infected dogs presented high levels of pro-MMP-2 in the CSF and elevated levels of pro-MMP-2 and pro-MMP-9 in the cerebellar tissue. Active MMP-2 was detected in the CSF of some infected dogs. As active MMP-2 and MMP-9 are required for cellular migration across the blood-brain barrier and any interference between MMPs and their inhibitors may result in an amplification of demyelination, this study gives additional support to the involvement of MMPs during subacute distemper leukoencephalitis and suggests that MMP-2 and MMP-9 may take part in the brain inflammatory changes of this disease.

  13. 结直肠癌患者血清中MMP-2、MMP-9和MMP-14检测的临床意义%The clinical significance of MMP-2,MMP-9 and MMP-14 in patients with colorectal carcinoma

    Institute of Scientific and Technical Information of China (English)

    万彦彬

    2010-01-01

    目的 探讨MMP-2、MMP-9及MMP-14在结直肠癌患者血清中的表达水平,并分析其与结直肠癌分化程度、Dukes分期及淋巴结转移等病理参数的关系,以更好的指导临床工作.方法 应用ELISA(酶联免疫吸附实验)分别检测200例结直肠癌患者(观察组)、60例健康成人(对照组)血清中MMP-2、MMP-9和MMP-14的含量.结果 观察组血清中MMP-2、MMP-9及MMP-14表达量显著高于对照组(P<0.01),观察组中不同临床特征患者血清MMP-2、MMP-9和MMP-14的表达与肿瘤分化程度、Dukes分期以及淋巴结转移有关(P<0.01),经相关性分析,MMP-2和MMP-9、MMP-9和MMP-14的表达呈正相关(P均<0.05).结论 MMP-2、MMP-9和MMP-14在结直肠癌患者血清中高表达,三者可能在结直肠癌发生发展中起重要作用;早期联合检测MMP-2、MMP-9和MMP-14可能对判断患者的预后及指导临床治疗有重要价值.

  14. Expression of GPC3, MMP-9 and MMP-14 in Hepatocellular Carcinoma and Their Influence on the Prognosis of Patients

    Directory of Open Access Journals (Sweden)

    Lei CAI

    2016-03-01

    Full Text Available Objective: To explore the expression of glypican-3 (GPC3, metal matrix proteinase (MMP-9 Methods: Totally 112 paraffin-embedded tissue samples of HCC patients were selected as observation group and 70 normal tissue samples were as control group. The expressions of GPC3, MMP-9 and MMP-14 of two groups were detected using immunohistochemistry assay. The positive rates of two groups were calculated. The relationship between the expression of GPC3, MMP-9 and MMP-14 and clinicopathological features, and their influence on the survival time of HCC patients were compared. Results: The positive expression rates of GPC3, MMP-9 and MMP-14 were higher in observation group that those in control group, the differences were statistically significant (P=0.000; P=0.000; P=0.000. The expression of GPC3 had close relationship with tumor volume, differentiated degree, lymphatic metastasis, and PCNA expression. The expression of MMP-9 had close relationship with tumor volume, lymphatic metastasis, and vascular invasion. The expression of GPC3 had close relationship with tumor volume, differentiated degree, lymphatic metastasis, vascular invasion, and proliferating cell nuclear antigen (PCNA expression.Conclusion: GPC3, MMP-9 and MMP-14 are highly expressed in HCC patients, which shows poor prognosis. Therefore, the detection of GPC3, MMP-9 and MMP-14 after surgery has a certain value on assessment of the prognosis of HCC patients.and MMP-14 in hepatocellular carcinoma (HCC, and their influence on the prognosis of HCC patients. There were positive correlations between GPC3 and MMP-9 (r=0.538, P=0.042, MMP-9 and MMP-14 (r=0.430, P=0.024, and GPC3 and MMP-14Kaplan-Meier method showed that the expressions of GPC3, MMP-9 and MMP-14 were associated with the prognosis of HCC patients, and patients with high expressions of GPC3, MMP-9 and MMP-14 had poor prognosis. (r=0.563, P=0.563.

  15. Use Of The Operational Air Quality Monitor (AQM) For In-Flight Water Testing Project

    Science.gov (United States)

    Macatangay, Ariel

    2014-01-01

    A primary requirement for manned spaceflight is Environmental Health which ensures air and water contaminants, acoustic profiles, microbial flora, and radiation exposures within the cabin are maintained to levels needed for crew health and for vehicle system functionality. The reliance on ground analyses of returned samples is a limitation in the current environmental monitoring strategy that will prevent future Exploration missions beyond low-Earth orbit. This proposal attempts to address this shortcoming by advancing in-flight analyses of water and air. Ground analysis of in-flight, air and water samples typically employ vapor-phase analysis by gas chromatography-mass spectrometry (GC-MS) to identify and quantify organic compounds present in the samples. We envision the use of newly-developed direct ionization approaches as the most viable avenue leading towards an integrated analytical platform for the monitoring of water, air, and, potentially bio-samples in the cabin environment. Development of an in-flight instrument capable of analyzing air and water samples would be the logical next step to meeting the environmental monitoring needs of Exploration missions. Currently, the Air Quality Monitor (AQM) on-board ISS provides this specific information for a number of target compounds in the air. However, there is a significant subset of common target compounds between air and water. Naturally, the following question arises, "Can the AQM be used for both air and water quality monitoring?" Previous directorate-level IR&D funding led to the development of a water sample introduction method for mass spectrometry using electrothermal vaporization (ETV). This project will focus on the integration of the ETV with a ground-based AQM. The capabilities of this integrated platform will be evaluated using a subset of toxicologically important compounds.

  16. CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability.

    Science.gov (United States)

    Liu, Wen-Hsin; Chen, Yeh-Long; Chang, Long-Sen

    2012-12-01

    This study explores the CIL-102 suppression mechanism on matrix metalloproteinase-2 (MMP-2) and MMP-9 expression in human leukemia K562 cells. CIL-102 attenuated K562 cell invasion with decreased MMP-2/MMP-9 protein expression and mRNA levels. Moreover, CIL-102 reduced luciferase activity of MMP-2/MMP-9 promoter constructs and MMP-2/MMP-9 mRNA stability. CIL-102 treatment induced JNK and p38 MAPK activation but reduced the phospho-ERK level. Transfection of constitutively active MEK1 restored MMP-2 and MMP-9 promoter activity in CIL-102-treated cells, while suppression of p38 MAPK/JNK activation abolished CIL-102-induced MMP-2/MMP-9 mRNA decay. CIL-102-induced p38 MAPK/JNK activation led to protein phosphatase 2A-mediated tristetraprolin (TTP) down-regulation. The reduction in TTP-KH-type splicing regulatory protein (KSRP) complexes formation promoted KSRP-mediated MMP-2/MMP-9 mRNA decay in CIL-102-treated K562 cells. Moreover, CIL-102 reduced invasion and MMP-2/MMP-9 expression in breast and liver cancer cells. Taken together, our data indicate that CIL-102 induces MMP-2/MMP-2 down-regulation via simultaneous suppression of genetic transcription and mRNA stability, and suggest a potential utility for CIL-102 in reducing MMP-2/MMP-9-mediated cancer progression.

  17. IMPROVING CLIENT INTERNAL CAPABILITY TO MONITOR PUBLIC-PRIVATE PARTNERSHIPS PROJECTS: A REVIEW

    Directory of Open Access Journals (Sweden)

    Abdullahi Ahmed Umar

    2012-01-01

    Full Text Available Public-Private Partnerships (PPP or Private Finance Initiatives (PFI are increasingly becoming very popular with governments across the globe for the provision of public infrastructure and services. When contracted, the public sector client believing the private sector will act in accordance with ‘bounded rationality’, ignores the constant monitoring and review process which is an integral part of any project. However, the failures of some of these partnerships and the social and economic costs incurred due to laxity in monitoring reminds us of the need to develop the permanent bureaucratic machinery of government, who share the government’s unique objectives of end-users satisfaction rather than shareholders’, to perform the monitoring of these projects. Though the public sector has been delivering projcets for dacades, the complexities associated with the PFI strategy has opened up new challenges for its staff. Most failures and moral harzards are only discovered after scandals evoke investigations like the case of Enron or when public criticisms force the government to reverse their decision as in the case of the Skye toll bridge by which time a lot of damage would have be done. Literature has shown that when employees are trained and engaged in organisational decisions and policy planning they make policy executions easier. Therefore, considering the Theoretical ideology behind the PFI of the asset being returned to the Public sector at the end of the concession, it becomes pertinent for proper training of the public sector staff. Public sector officials, if adequately trained and motivated can perform the tasks being contracted out to private consultants thereby re-affirming government’s commitment to its Value for Money (VFM proposition. Though the public sector staff strength has been depleted due to the adoption of New Public Management (NPM, however the remaining qualified staff can be pooled to create an

  18. High altitude environmental monitoring: the SHARE project and CEOP-HE

    Science.gov (United States)

    Tartari, G.

    2009-04-01

    Mountain areas above 2,500 m a.s.l. constitute about 25% of the Earth's surface and play a fundamental role in the global water balance, while influencing global climate and atmospheric circulation systems. Several millions, including lowlanders, are directly affected by the impacts of climate change on glaciers and water resource distribution. Mountains and high altitude plateaus are subject to the highest rate of temperature increase (e.g., Tibetan Plateau) and are recognized as particularly vulnerable to the effects of climate change. In spite of this, the number of permanent monitoring sites in the major environmental networks decreases with altitude. On a sample of two hundred high altitude automatic weather stations located above 2,500 m a.s.l., less than 20% are over 4,000 m, while there are only 24 stations in the world that could be considered "complete" high altitude observatories. Furthermore, entire mountain areas are left uncovered, creating significant data gaps which make reliable modelling and forecasting nearly impossible. In response to these problems, Ev-K2-CNR has developed the project SHARE (Stations at High Altitude for Research on the Environment) with the support of the Italian government and in collaboration with UNEP. This integrated environmental monitoring and research project aims to improve knowledge on the local, regional and global consequences of climate change in mountain regions and on the influence of high elevations on climate, atmospheric circulation and hydrology. SHARE today boasts a network of 13 permanent monitoring stations between 2,165 m and 8,000 m. Affiliated researchers have produced over 150 scientific publications in atmospheric sciences, meteorology and climate, glaciology, limnology and paleolimnology and geophysics. SHARE network data is also contributed to international programs (UNEP-ABC, WMO-GAW, WCRP-GEWEX-CEOP, NASA-AERONET, ILTER, EU-EUSAAR, EU-ACCENT). Within this context, the CEOP-High Elevations (CEOP

  19. Role Of MMP-2 and MMP-9 in Resistance to Drug Therapy in Patients with Resistant Hypertension

    Directory of Open Access Journals (Sweden)

    Leandro Lacerda

    2015-01-01

    Full Text Available Background: Despite the increased evidence of the important role of matrix metalloproteinases (MMP-9 and MMP‑2 in the pathophysiology of hypertension, the profile of these molecules in resistant hypertension (RHTN remains unknown. Objectives: To compare the plasma levels of MMP-9 and MMP-2 and of their tissue inhibitors (TIMP-1 and TIMP-2, respectively, as well as their MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios, between patients with controlled RHTN (CRHTN, n=41 and uncontrolled RHTN (UCRHTN, n=35. In addition, the association of those parameters with clinical characteristics, office blood pressure (BP and arterial stiffness (determined by pulse wave velocity was evaluate in those subgroups. Methods: This study included 76 individuals diagnosed with RHTN and submitted to physical examination, electrocardiogram, and laboratory tests to assess biochemical parameters. Results: Similar values of MMP-9, MMP-2, TIMP-1, TIMP-2, and MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios were found in the UCRHTN and CRHTN subgroups (P>0.05. A significant correlation was found between diastolic BP (DBP and MMP-9/TIMP-1 ratio (r=0.37; P=0.02 and DPB and MMP-2 (r=-0.40; P=0.02 in the UCRHTN subgroup. On the other hand, no correlation was observed in the CRHTN subgroup. Logistic regression models demonstrated that MMP-9, MMP-2, TIMP-1, TIMP-2 and their ratios were not associated with the lack of BP control. Conclusion: These findings suggest that neither MMP-2 nor MMP-9 affect BP control in RHTN subjects.

  20. The Expressions of MMP-9,MMP-14,MMP-2 and VEGF-C in Breast Cancer and Their Significance%MMP-9、MMP-14、MMP-2和VEGF-C在乳腺癌中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    钱红; 曹桂明; 牛国梁; 杨梅; 黎晴

    2013-01-01

    [目的]探讨MMP-9、MMP-14、MMP-2和VEGF-C在乳腺癌中的表达及意义.[方法]用组织芯片和免疫组化技术检测乳腺良性病变及乳腺癌组织中MMP-2、MMP-9、MMP-14、VEGF-C的表达水平;用D2-40标记淋巴管并计数.[结果]MMP-9、MMP-14、MMP-2与VEGF-C在乳腺癌组织中的表达率及表达强度远高于乳腺良性病变组织,并呈正相关关系(r=-0.27、0.35、0.27、0.26);浸润性乳腺癌VEGF-C阳性表达率有淋巴结转移者明显高于无淋巴结转移者,差异有统计学意义(P<0.01).[结论] MMP-9、MMP-14、MMP-2与VEGF-C的表达与乳腺癌淋巴管生成及淋巴结转移关系密切并呈正相关.

  1. The ISTIMES project: a new integrated system for monitoring critical transport infrastructures interested by natural hazards

    Science.gov (United States)

    Proto, Monica; Massimo, Bavusi; Francesco, Soldovieri

    2010-05-01

    The research project "Integrated System for Transport Infrastructure surveillance and Monitoring by Electromagnetic Sensing" (ISTIMES), was approved in the 7th Framework Programme, in the Joint Call ICT and Security and started on 1st July 2009. The purpose of ISTIMES project is to design, assess and promote an ICT-based system, exploiting distributed and local sensors, for non-destructive electromagnetic monitoring in order to achieve the critical transport infrastructures more reliable and safe. The transportation sector's components are susceptible to the consequences of natural disasters and can also be attractive as terrorist targets. The sector's size, its physically dispersed and decentralized nature, the many public and private entities involved in its operations, the critical importance of cost considerations, and the inherent requirement of convenient accessibility to its services by all users - make the transportation particularly vulnerable to security and safety threats. As well known, the surface transportation system consists of interconnected infrastructures including highways, transit systems, railroads, airports, waterways, pipelines and ports, and the vehicles, aircraft, and vessels that operate along these networks. Thus, interdependencies exist between transportation and nearly every other sector of the economy and the effective operation of this system is essential to the European economic productivity; therefore, transportation sector protection is of paramount importance since threats to it may impact other industries that rely on it. The system exploits an open network architecture that can accommodate a wide range of sensors, static and mobile, and can be easily scaled up to allow the integration of additional sensors and interfacing with other networks. It relies on heterogeneous state-of-the-art electromagnetic sensors, enabling a self-organizing, self-healing, ad-hoc networking of terrestrial sensors, supported by specific satellite

  2. Electromagnetic monitoring of the Earth's interior in the frame of the MEM Project

    Directory of Open Access Journals (Sweden)

    L. Santarelli

    2008-06-01

    Full Text Available The MEM Project (Magnetic and Electric fields Monitoring was activated in the INGV Observatory of L’Aquila since 2004. The principal purpose of the project is to create in Central Italy a network of observatories to monitoring the electromagnetic signals in the frequency band [0.001 Hz - 100 kHz]. This band includes natural signals (magnetic pulsations of magnetospheric origin, Earth-ionosphere resonance mode signals, atmospheric noise, and so on and artificial signals (power line emissions, VLF radio transmissions, and so on. The innovative characteristic of the project is the approach chosen to study the complex problem concerning the representation of the spatial and temporal distributions of the electromagnetic fields in the band of interest. Both the distributions can be represented by some parameters containing the locations and the characteristics of the sources of the electromagnetic signals. When all the stations will be in operation the wide-band interferometry will be applied. Combining the simultaneous observations of the electromagnetic field measured in the stations of the network, we will be able to obtain detailed information about the investigated electromagnetic sources. A new measurement system has been developed to fulfil these requirements focusing on the automation of the measurements. The system is designed for long term recording of the electromagnetic fields in a wide frequency band. In the frequency band [1Hz - 100 kHz] the three components of the magnetic field and the three components of atmospheric electric field are processed in real time using DSP (Digital Signal Processing techniques. In the frequency band [0.001 - 25]Hz the two components of the telluric field and the three components of the magnetic field are recorded as sampled (100Hz. One of the main scientific objectives of the MEM project is the long term monitoring of the geodynamical processes, such as the earthquakes, by the calculation of the Poynting

  3. Twist1,MMP-2和MMP-9在结直肠癌组织中的表达及意义%Expression of Twist1, MMP-2 and MMP-9 in colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    杨振忠; 吴正升; 法文; 李守新; 吕永芳

    2011-01-01

    目的:研究Twist1、MMP-2和MMP-9蛋白在结直肠癌组织中的表达及其相互关系.方法:建立组织微阵列平台,应用免疫组织化学方法检测92例结直肠癌组织Twist1、MMP-2和MMP-9蛋白的表达情况.结果:结直肠癌中Twist1的表达率为64.1%,MMP-2和MMP-9阳性率分别为66.3%和67.4%;Twist1的表达与肿瘤淋巴结受累和TNM分期均呈正相关(均P<0.05),并且与患者总生存率和无复发生存率呈负相关(P<0.01,P<0.05);MMP-2、MMP-9蛋白表达与肿瘤淋巴结受累均呈显著正相关(均P<0.01),并且MMP-9蛋白表达与肿瘤大小也呈显著正相关(P<0.01);Twist1表达状况与MMP-9的表达呈显著正相关(r=0.205,P<0.05),而与MMP-2表达无显著相关性.结论:结直肠癌Twist1、MMP-2和MMP-9表达状况与肿瘤侵袭转移有密切关系;MMP-9表达可能在一定水平上受到Twist1调控.%AIM: To investigate the clinical significance of the expression of Twist1, MMP-2 and MMP-9 proteins in colorectal cancer.METHODS: The expression of Twist1, MMP-2 and MMP-9 proteins was examined on tissue chips containing 92 colorectal cancer samples by immunohistochemistry.RESULTS: The positive rates of Twist1, MMP-2 and MMP-9 protein expression in colorectal cancer were 64.1%, 66.3% and 67.4%, respectively.High expression of Twist1 was positively correlated with lymph node metastasis and TNM stage (both P < 0.05) but inversely with patient's overall survival and relapse-free survival (P<0.05 and 0.01, respectively).The expression of MMP-2 and MMP-9 was significantly correlated with lymph node metastasis (both P < 0.01).A positive correlation was also found between MMP-9 expression and tumor size (P < 0.01).The expression of Twist1 was positively correlated with that of MMP-9 (P < 0.05), but not with that of MMP-2 (P >0.05).CONCLUSION: The expression of Twist1, MMP-2 and MMP-9 plays an important role in tumor invasion and metastasis in colorectal cancer.The expression of

  4. MMP-1 polymorphism and its relationship to pathological processes

    Indian Academy of Sciences (India)

    P A Arakaki; M R Marques; M C L G Santos

    2009-06-01

    Matrix metalloproteinases (MMPs) are a family of zinc (Zn)-dependent endopeptidases that are collectively capable of cleaving virtually all extracellular matrix (ECM) substrates and play an important role in diverse physiological and pathological processes. The activity of MMPs is regulated at multiple levels. The transcriptional regulation of MMP appears to represent the key step in MMP regulation. There are diverse types of MMPs that differ structural and functionally. MMP-1 is the most ubiquitously expressed interstitial collagenase and has a prominent role in initial cleavage of the ECM. The level of MMP-1 expression can be influenced by different single-nucleotide polymorphisms (SNPs) in the promoter region. A functional polymorphism at position –1607 has been shown to alter the transcriptional activity of MMP-1 and was associated with diverse pathological processes. The aim of our review was to discuss some topics related to MMP in physiological and pathological processes, with a focus on MMP-1 polymorphism.

  5. New idea of geomagnetic monitoring through ENA detection from the International Space Station: ENAMISS project

    Science.gov (United States)

    Milillo, Anna; De Angelis, Elisabetta; Orsini, Stefano; Rubini, Alda; Evangelista, Yuri; Mura, Alessandro; Rispoli, Rosanna; Vertolli, Nello; Carrubba, Elisa; Donati, Alessandro; Di Lellis, Andrea Maria; Plainaki, Christina; Lazzarotto, Francesco

    2016-04-01

    Remote sensing of Energetic Neutral Atoms (ENA) in the Earth's environment has been proven to be a successful technique able to provide detailed information on the ring current plasma population at energies below 100 keV. Indeed, the existing space weather databases usually include a good coverage of Sun and solar wind monitoring. The global imaging of the Earth's magnetosphere/ ionosphere is usually obtained by the high-latitudes monitoring of aurorae, ground magnetic field variations and high-latitude radio emissions. The equatorial magnetic field variations on ground, from which the geomagnetic indices like Dst, Sym-H and Asym-H are derived, include the effects of all current systems (i.e. ring current, Chapman -Ferraro current, tails currents, etc...) providing a kind of global information. Nevertheless, the specific information related to the ring current cannot be easily derived from such indices. Only occasional local plasma data are available by orbiting spacecraft. ENA detection is the only way to globally view the ring current populations. Up-to-now this technique has been used mainly from dedicated high altitude polar orbiting spacecraft, which do not allow a continuous and systematic monitoring, and a discrimination of the particle latitude distribution. The Energetic Neutral Atoms Monitor on the International space Station (ENAMISS) project intends to develop an ENA imager and install it on the ISS for continuous monitoring of the spatially distributed ring current plasma population. ISS is the ideal platform to perform continuous ENA monitoring since its particular low altitude and medium/low latitude orbit allows wide-field ENA images of various magnetospheric regions. The calibrated ENA data, the deconvolved ion distributions and ad-hoc ENA-based new geomagnetic indices will be freely distributed to the space weather community. Furthermore, new services based on plasma circulation models, spacecraft surface charging models and radiation dose models

  6. The SSC cycle: a PDCA approach to address site-specific characteristics in a continuous shallow water quality monitoring project.

    Science.gov (United States)

    Miles, Eduardo J

    2008-05-01

    In any water quality-monitoring project there are several critical success factors that must be adequately addressed in order to ensure the implementation and realization of the monitoring objectives. Site selection is one of these critical success factors. The monitoring sites must be selected to comply with the monitoring and data quality objectives. In the real world, ideal monitoring setting conditions are difficult to achieve, and compromises must be made in order to locate the monitoring stations that best represent the environment to be monitored. Site-specific characteristics are all the environmental, logistical and management factors particular to the monitoring site, that could influence the fulfilment of the monitoring and data quality objectives. Therefore, during the site selection process, it is essential to properly consider and evaluate these site-specific characteristics. The SSC cycle was developed with this goal in mind, to assist the monitoring team to systematically address site-specific characteristics. The cycle is a methodology to organize the site-specific characteristics in different categories, and to ensure a comprehensive overview of these characteristics throughout the project life cycle.

  7. Sustainable Seas Student Intertidal Monitoring Project at Duxbury Reef in Bolinas, CA

    Science.gov (United States)

    Boesel, A.; Soave, K.; Dean, A.; Grimaldi, Z.; Buie, A.; Dattels, C.; Steiger, C.; Wallace, K.; Salmi, I.; Tillapaugh, J.

    2011-12-01

    Kathy Soave, Amy Dean, Alexa Boesel, Andrew Buie, Celia Dattels, Zoe Grimaldi, Isabella Salmi, Cameryn Steiger, Joey Tillapaugh, Kathleen Wallace The Sustainable Seas Student Monitoring Project at the Branson School in Ross, CA has monitored Duxbury Reef in Bolinas, CA since 1999, in cooperation with the Farallones Marine Sanctuary Association and the Gulf of Farallones National Marine Sanctuary. Goals of this student-run project include: 1) To monitor the rocky intertidal habitat and develop a baseline database of invertebrates and algal density and abundance; 2) To contribute to the conservation of the rocky intertidal habitat through education of students and visitors about intertidal species and the requirements for maintaining a healthy, diverse intertidal ecosystem; 3) To increase stewardship in the Gulf of the Farallones National Marine Sanctuary; and 4) To contribute abundance and population data on key algae and invertebrate species to the national database, LiMPETS (Long Term Monitoring Program & Experiential Training for Students). Student volunteers complete an intensive training course on the natural history of intertidal invertebrates and algae, identification of key species, rocky intertidal monitoring techniques, and history of the sanctuary. Students identify and count key invertebrate and algae species along two permanent transects and, using randomly determined points, within a permanent 100 m2 area, three times per year (fall, winter, and late spring). Using the data collected since 2004, we will once again compare population densities, seasonal abundance and long-term population trends of key algal and invertebrate species, including Tegula funebralis and Anthopluera elegantissima. Future analyses and investigations will include intertidal abiotic factors (including water temperature and human foot-traffic) to enhance insights into the workings of the Duxbury Reef ecosystem, in particular, the high and mid-intertidal zones experiencing the

  8. The Lick AGN Monitoring Project: Photometric Light Curves and Optical Variability Characteristics

    CERN Document Server

    Walsh, Jonelle L; Bentz, Misty C; Barth, Aaron J; Baliber, Nairn; Li, Weidong; Stern, Daniel; Bennert, Vardha Nicola; Brown, Timothy M; Canalizo, Gabriela; Filippenko, Alexei V; Gates, Elinor L; Greene, Jenny E; Malkan, Matthew A; Sakata, Yu; Street, Rachel A; Treu, Tommaso; Woo, Jong-Hak; Yoshii, Yuzuru

    2009-01-01

    The Lick AGN Monitoring Project targeted 13 nearby Seyfert 1 galaxies with the intent of measuring the masses of their central black holes using reverberation mapping. The sample includes 12 galaxies selected to have black holes with masses roughly in the range 10^6-10^7 solar masses, as well as the well-studied AGN NGC 5548. In conjunction with a spectroscopic monitoring campaign, we obtained broad-band B and V images on most nights from 2008 February through 2008 May. The imaging observations were carried out by four telescopes: the 0.76-m Katzman Automatic Imaging Telescope (KAIT), the 2-m Multicolor Active Galactic Nuclei Monitoring (MAGNUM) telescope, the Palomar 60-in (1.5-m) telescope, and the 0.80-m Tenagra II telescope. Having well-sampled light curves over the course of a few months is useful for obtaining the broad-line reverberation lag and black hole mass, and also allows us to examine the characteristics of the continuum variability. In this paper, we discuss the observational methods and the ph...

  9. Yakima/Klickitat Fisheries Project; Klickitat Only Monitoring and Evaluation, 2002-2003 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Sampson, Melvin; Evenson, Rolf

    2003-12-01

    The monitoring and evaluation activities described in this report were determined by consensus of the scientists from the Yakama Nation (YN). Klickitat Subbasin Monitoring and Evaluation (M&E) activities have been subjected to scientific and technical review by members of YKFP's Science/Technical Advisory Committee (STAC) as part of the YKFP's overall M&E proposal. Yakama Nation YKFP project biologists have transformed the conceptual design into the tasks described. This report summarizes progress and results for the following major categories of YN-managed tasks under this contract: (1) Monitoring and Evaluation - Accurately characterize baseline available habitat and salmonid populations pre-habitat restoration and pre-supplementation. (2) EDT Modeling - Identify and evaluate habitat and artificial production enhancement options. (3) Genetics - Characterize the genetic profile of wild steelhead in the Klickitat Basin. (4) Ecological Interactions - Determine the presence of pathogens in wild and naturally produced salmonids in the Klickitat Basin and develop supplementation strategies using this information.

  10. 2015 Groundwater Monitoring Report Project Shoal Area: Subsurface Correction Unit 447

    Energy Technology Data Exchange (ETDEWEB)

    Findlay, Rick [Navarro Research and Engineering, Oak Ridge, TN (United States)

    2016-04-01

    The Project Shoal Area in Nevada was the site of a 12-kiloton-yield underground nuclear test in 1963. Although the surface of the site has been remediated, investigation of groundwater contamination resulting from the test is still in the corrective action process. Annual sampling and hydraulic head monitoring are conducted at the site as part of the subsurface corrective action strategy. The corrective action strategy is currently focused on revising the site conceptual model (SCM) and evaluating the adequacy of the monitoring well network. Some aspects of the SCM are known; however, two major concerns are the uncertainty in the groundwater flow direction and the cause of rising water levels in site wells west of the shear zone. Water levels have been rising in the site wells west of the shear zone since the first hydrologic characterization wells were installed in 1996. Although water levels in wells west of the shear zone continue to rise, the rate of increase is less than in previous years. The SCM will be revised, and an evaluation of the groundwater monitoring network will be conducted when water levels at the site have stabilized to the agreement of both the U.S. Department of Energy Office of Legacy Management and the Nevada Division of Environmental Protection.

  11. Expression and clinical significance of MMP-2, MMP-7 and MMP-14 in the tissue of patients with gastric cancer%MMP-2、MMP-7和MMP-14在胃癌患者组织中表达的临床意义

    Institute of Scientific and Technical Information of China (English)

    王一波; 汤黎明

    2015-01-01

    目的 探讨胃癌组织中MMP-2、MMP-7和MMP-14的表达及临床意义.方法 应用链霉素抗生物素蛋白-过氧化酶免疫组化染色法(S-P)法检测98例胃癌组织中MMP-2、MMP-7和MMP-14蛋白的表达.对照组20例为良性胃病变黏膜组织.结果 胃癌组中MMP-2、MMP-7和MMP-14表达的阳性率明显高于对照组(P<0.05);胃癌组中MMP-2及MMP-14的阳性表达率与胃癌的肿瘤浸润深度、淋巴转移、肿瘤大小、大体分型、临床肿瘤分期有关(P <0.05或P<0.01).MMP-7的阳性表达率与胃癌的肿瘤浸润深度、淋巴转移、分化程度、大体分型、临床肿瘤分期有关(P <0.05或P<0.01).MMP-2和MMP-7蛋白表达正相关性(r=0.271,P<0.01):MMP-2和MMP-14蛋白表达正相关性(r=0.268,P=<0.01);MMP-7和MMP-14蛋白表达正相关性(r =0.202,P<0.05).结论 MMP-2、MMP-7、MMP-14的表达上调与胃癌的浸润和转移有关.

  12. California Groundwater Ambient Monitoring and Assessment (GAMA) Program Priority Basin Project--shallow aquifer assessment

    Science.gov (United States)

    ,

    2013-01-01

    The California State Water Resources Control Board’s (SWRCB) GAMA Program is a comprehensive assessment of statewide groundwater quality in California. From 2004 to 2012, the GAMA Program’s Priority Basin Project focused on assessing groundwater resources used for public drinking-water supplies. More than 2,000 public-supply wells were sampled by U.S. Geological Survey (USGS) for this effort. Starting in 2012, the GAMA Priority Basin Project began an assessment of water resources in shallow aquifers in California. These shallow aquifers provide water for domestic and small community-supply wells, which are often drilled to shallower depths in the groundwater system than public-supply wells. Shallow aquifers are of interest because shallow groundwater may respond more quickly and be more susceptible to contamination from human activities at the land surface, than the deeper aquifers. The SWRCB’s GAMA Program was developed in response to the Groundwater Quality Monitoring Act of 2001 (Water Code sections 10780-10782.3): a public mandate to assess and monitor the quality of groundwater resources used for drinking-water supplies, and to increase the availability of information about groundwater quality to the public. The U.S. Geological Survey is the technical lead of the Priority Basin Project. Stewardship of California’s groundwater resources is a responsibility shared between well owners, communities, and the State. Participants and collaborators in the GAMA Program include Regional Water Quality Control Boards, Department of Water Resources, Department of Public Health, local and regional groundwater management entities, county and local water agencies, community groups, and private citizens. Well-owner participation in the GAMA Program is entirely voluntary.

  13. Monitoring Air Quality over China: Evaluation of the modeling system of the PANDA project

    Science.gov (United States)

    Bouarar, Idir; Katinka Petersen, Anna; Brasseur, Guy; Granier, Claire; Xie, Ying; Wang, Xuemei; Fan, Qi; Wang, Lili

    2015-04-01

    Air pollution has become a pressing problem in Asia and specifically in China due to rapid increase in anthropogenic emissions related to growth of China's economic activity and increasing demand for energy in the past decade. Observed levels of particulate matter and ozone regularly exceed World Health Organization (WHO) air quality guidelines in many parts of the country leading to increased risk of respiratory illnesses and other health problems. The EU-funded project PANDA aims to establish a team of European and Chinese scientists to monitor air pollution over China and elaborate air quality indicators in support of European and Chinese policies. PANDA combines state-of-the-art air pollution modeling with space and surface observations of chemical species to improve methods for monitoring air quality. The modeling system of the PANDA project follows a downscaling approach: global models such as MOZART and MACC system provide initial and boundary conditions to regional WRF-Chem and EMEP simulations over East Asia. WRF-Chem simulations at higher resolution (e.g. 20km) are then performed over a smaller domain covering East China and initial and boundary conditions from this run are used to perform simulations at a finer resolution (e.g. 5km) over specific megacities like Shanghai. Here we present results of model simulations for January and July 2010 performed during the first year of the project. We show an intercomparison of the global (MACC, EMEP) and regional (WRF-Chem) simulations and a comprehensive evaluation with satellite measurements (NO2, CO) and in-situ data (O3, CO, NOx, PM10 and PM2.5) at several surface stations. Using the WRF-Chem model, we demonstrate that model performance is influenced not only by the resolution (e.g. 60km, 20km) but also the emission inventories used (MACCity, HTAPv2), their resolution and diurnal variation, and the choice of initial and boundary conditions (e.g. MOZART, MACC analysis).

  14. The Walla Walla Basin Natural Production Monitoring and Evaluation Project : Progress Report, 1999-2002.

    Energy Technology Data Exchange (ETDEWEB)

    Contor, Craig R.; Sexton, Amy D.

    2003-06-02

    The Walla Walla Basin Natural Production Monitoring and Evaluation Project (WWNPME) was funded by Bonneville Power Administration (BPA) as directed by section 4(h) of the Pacific Northwest Electric Power Planning and Conservation Act of 1980 (P. L. 96-501). This project is in accordance with and pursuant to measures 4.2A, 4.3C.1, 7.1A.2, 7.1C.3, 7.1C.4 and 7.1D.2 of the Northwest Power Planning Council's (NPPC) Columbia River Basin Fish and Wildlife Program (NPPC 1994). Work was conducted by the Fisheries Program of the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) under the Walla Walla Basin Natural Production Monitoring and Evaluation Project (WWNPME). Chapter One provides an overview of the entire report and how the objectives of each statement of work from 1999, 2000, 2001, and 2002 contract years are organized and reported. Chapter One also provides background information relevant to the aquatic resources of the Walla Walla River Basin. Objectives are outlined below for the statements of work for the 1999, 2000, 2001 and 2002 contract years. The same objectives were sometimes given different numbers in different years. Because this document is a synthesis of four years of reporting, we gave objectives letter designations and listed the objective number associated with the statement of work for each year. Some objectives were in all four work statements, while other objectives were in only one or two work statements. Each objective is discussed in a chapter. The chapter that reports activities and findings of each objective are listed with the objective below. Because data is often interrelated, aspects of some findings may be reported or discussed in more than one chapter. Specifics related to tasks, approaches, methods, results and discussion are addressed in the individual chapters.

  15. Overexpression of matrix metalloproteinase-12 (MMP-12) correlates with radiation-induced lung fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Myung Gu; Jeong, Ye Ji; Lee, Haejune [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Lee, Sujae [Hanyang Univ., Seoul (Korea, Republic of)

    2014-05-15

    MMPs are classified into five subgroups: collagenases (MMP-1, MMP-8, MMP-13), gelatinases (MMP-2, MMP-9), stromelysins (MMP-3, MMP-10, MMP-11), as well as metalloelastase (MMP-12), the membrane-type MMPs (MMP14, MMP15), and other MMPS (e. g., MMP-19, and MMP20). MMP-12 (matrix metalloproteinase12), also known as macrophage metalloelastase, was first identified as an elastolytic metalloproteinase secreted by inflammatory macrophages 30 years ago. MMP-12 degrades extracellular matrix (ECM) components to facilitate tissue remodeling. It can degrade elastin and other substrates, such as type IV collagen, fibronectin, laminin, gelatin, vitronectin, entactin, heparin, and chondroitin sulfates. In the lung, MMP-12 is identified in alveolar macrophages of cigarette smokers as an elastolytic MMP. Inactivation of the MMP-12 gene in knockout mice demonstrates a critical role of MMP-12 in smoking-induced chronic obstructive pulmonary disease (COPD). The aim of the present study was to investigate the effects of MMP-12 by radiation in lung, so we evaluate that MMP-12 expression pattern in normal lung tissue and cancer cell following radiation. Radiation induced lung injury most commonly occurs as a result of radiation therapy administered to treat cancer. The present study demonstrates that MMP-12 was highly increased in the lung damaged by radiation Thus, MMP-12 might be of potential relevance as a clinically diagnostic tool and sensitive biomarker for radiation induced lung injury and fibrosis.

  16. Environmental monitoring for the hot dry rock geothermal energy development project. Annual report, July 1975--June 1976

    Energy Technology Data Exchange (ETDEWEB)

    Pettitt, R.A. (comp.)

    1976-09-01

    The objectives of this environmental monitoring report are to provide a brief conceptual and historical summary of the Hot Dry Rock Geothermal Project, a brief overview of the environmental monitoring responsibilities and activities of the Los Alamos Scientific Laboratory, and descriptions of the studies, problems, and results obtained from the various monitoring programs. Included are descriptions of the work that has been done in three major monitoring areas: (1) water quality, both surface and subsurface; (2) seismicity, with a discussion of the monitoring strategy of regional, local, and close-in detection networks; and (3) climatology. The purpose of these programs is to record baseline data, define potential effects from the project activities, and determine and record any impacts that may occur.

  17. A framework for monitoring and evaluating carbon mitigation by farm forestry projects. Example of a demonstration project in Chiapas, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    De Jong, B.H.J. [El Colegio de la Frontera Sur, Chiapas (Mexico); Tipper, R. [Institute of Ecology and Resource Management, University of Edinburgh, Edinburgh (United Kingdom); Taylor, J. [Union de Credito `Pajal Ya Kac Tic`, Chiapas (Mexico)

    1997-10-01

    In Mexico an estimated 4.5 x 10{sup 6} ha are available for farm forestry, while up to 6.1 x 10{sup 6} ha could be saved from deforestation by making shifting agriculture more productive and sustainable. Various farm forestry systems are technically, socially, and economically viable, including live fences, coffee with shade trees, plantations, tree enrichment of fallows, and taungya, with a C-sequestration potential varying from 17.6 to 176.3 Mg C ha{sup -1}. A self-reporting system with on-site spot checks is presented for the monitoring and evaluation (M and E), and will be tested in a farm forestry C-sequestration pilot project, to begin in Chiapas, Mexico, in 1997. The M and E procedure will facilitate the collection of field data at low cost, help ensure that the system continue to address the needs of farmers, and give farmers an understanding of the value of the service that they are providing. 4 figs., 3 tabs., 20 refs.

  18. The power profile predicts road cycling MMP.

    Science.gov (United States)

    Quod, M J; Martin, D T; Martin, J C; Laursen, P B

    2010-06-01

    Laboratory tests of fitness variables have previously been shown to be valid predictors of cycling time-trial performance. However, due to the influence of drafting, tactics and the variability of power output in mass-start road races, comparisons between laboratory tests and competition performance are limited. The purpose of this study was to compare the power produced in the laboratory Power Profile (PP) test and Maximum Mean Power (MMP) analysis of competition data. Ten male cyclists (mean+/-SD: 20.8+/-1.5 y, 67.3+/-5.5 kg, V O (2 max) 72.7+/-5.1 mL x kg (-1) x min (-1)) completed a PP test within 14 days of competing in a series of road races. No differences were found between PP results and MMP analysis of competition data for durations of 60-600 s, total work or estimates of critical power and the fixed amount of work that can be completed above critical power (W'). Self-selected cadence was 15+/-7 rpm higher in the lab. These results indicate that the PP test is an ecologically valid assessment of power producing capacity over cycling specific durations. In combination with MMP analysis, this may be a useful tool for quantifying elements of cycling specific performance in competitive cyclists.

  19. SHynergie: Development of a virtual project laboratory for monitoring hydraulic stimulations

    Science.gov (United States)

    Renner, Jörg; Friederich, Wolfgang; Meschke, Günther; Müller, Thomas; Steeb, Holger

    2016-04-01

    Hydraulic stimulations are the primary means of developing subsurface reservoirs regarding the extent of fluid transport in them. The associated creation or conditioning of a system of hydraulic conduits involves a range of hydraulic and mechanical processes but also chemical reactions, such as dissolution and precipitation, may affect the stimulation result on time scales as short as hours. In the light of the extent and complexity of these processes, the steering potential for the operator of a stimulation critically depends on the ability to integrate the maximum amount of site-specific information with profound process understanding and a large spectrum of experience. We report on the development of a virtual project laboratory for monitoring hydraulic stimulations within the project SHynergie (http://www.ruhr-uni-bochum.de/shynergie/). The concept of the laboratory envisioned product that constitutes a preparing and accompanying rather than post-processing instrument ultimately accessible to persons responsible for a project over a web-repository. The virtual laboratory consists of a data base, a toolbox, and a model-building environment. Entries in the data base are of two categories. On the one hand, selected mineral and rock properties are provided from the literature. On the other hand, project-specific entries of any format can be made that are assigned attributes regarding their use in a stimulation problem at hand. The toolbox is interactive and allows the user to perform calculations of effective properties and simulations of different types (e.g., wave propagation in a reservoir, hydraulic test). The model component is also hybrid. The laboratory provides a library of models reflecting a range of scenarios but also allows the user to develop a site-specific model constituting the basis for simulations. The laboratory offers the option to use its components following the typical workflow of a stimulation project. The toolbox incorporates simulation

  20. 膀胱癌组织中 MMP-2 MMP-9蛋白表达研究

    Institute of Scientific and Technical Information of China (English)

    刘新郑; 杨锦建; 马长路; 贺付成

    2008-01-01

    目的 探讨膀胱癌组织中MMP-2,MMP-9蛋白的表达及其与膀胱肿瘤恶性程度和侵袭性之间的关系.方法 采用免疫组化方法检测47例膀胱癌及10例正常膀胱组织中MMP-2、MMP~9的表达.结果 与正常对照组相比.膀胱癌组织中MMP-2、MMP-9蛋白的表达明显增高.随肿瘤分级、分期的增高MMP-9和MMP-2的高表达率增高(P<0.05),MMP-2、MMP-9的高表达率同肿瘤分级、分期呈正相关.结论 MMP-2、MMP-9的高表达与膀胱癌的恶性程度有关,在膀胱癌的发生发展中起重要作用,可用于判断膀胱癌恶性程度及预后.

  1. An ex vivo study on immunohistochemical localization of MMP-7 and MMP-9 in temporomandibular joint discs with internal derangement

    Directory of Open Access Journals (Sweden)

    C. Loreto

    2013-04-01

    Full Text Available Internal derangement (ID is among the most common disorders of the temporomandibular joint (TMJ. Previous research by our group highlighted a correlation between apoptosis and TMJ ID. Metalloproteinases (MMP-7 and -9 have been shown to play an important role in extracellular matrix ECM homeostasis and, through it, in joint disc remodelling. The immunohistochemical expression of MMP-7 and -9 was investigated in discs from patients with TMJ ID and from healthy donors and compared with the degree of histological tissue degeneration. The collagen fibre arrangement in pathological discs exhibited varying degrees of disruption. New vessels were consistently detected; endothelial cells from these vessels were immunolabelled with both MMP-7 and MMP-9. More or less intense MMP-7 and MMP-9 immunolabelling was detected in the cytoplasm of disc cells from all patients. MMP-7 and MMP-9 immunostaining was significantly different between pathological and normal discs and correlated with the extent of histopathological degeneration. MMP-7 and MMP-9 upregulation in discs from patients with TMJ ID demonstrates their involvement in disc damage in this disorder. A greater understanding of these processes could help identify ways to curb MMP overproduction without affecting their tissue remodelling action. The design of specific inhibitors for these MMPs would not only help to gain insights into the biological roles of MMPs, but would also aid in developing therapeutic interventions for diseases associated with abnormal ECM degradation.

  2. Effect of LED irradiation on the expression of MMP-3 and MMP-13 in SW1353 cells in vitro

    Science.gov (United States)

    Zeng, Chang-chun; Guo, Zhou-yi; Zhang, Feng-xue; Deng, Wen-di; Liu, Song-hao

    2007-05-01

    Matrix Metalloproteinase (MMP) plays an active role in remodeling cartilage in osteoarthritic cartilage. To find an effective method of prevention of osteoclasia, this in vitro study focuses on the expression of MMP-3 and MMP-13 in the SW1353 cells by LED irradiation. The human chondrosarcoma cell line SW1353 were stimulated with the proinflammatory cytokine IL-1beta or tumor necrosis factor-alpha (TNF-alpha), and were received the irradiation of LED (632nm, 4mW/cm2). The cell count was assessed over a 96-hour period by using Trypan blue dye exclusion assay, and the cell activity was evaluated with a Cell Counting Kit-8 Assays. The subsequent expression of MMP-3 and MMP-13 was quantified. Results of this experiment showed that the cultural cell activity was decreased, and the expression of MMP-3 and MMP-13 was increased by being stimulated with IL-1beta or TNF-alpha. After received LED irradiation, the death rate of cultural cell was increased and the expression of MMP-3 and MMP-13 was decreased significantly. The present study concluded that particular LED irradiation stimulates SW1353 cell proliferation activity and inhibit the MMP-3 and MMP-13 enzymatic activity. These findings might be clinically relevant, indicating that the low power laser irradiation treatment is likely to achieve the repair of articular cartilage in clinic.

  3. Emergency monitoring strategy and radiation measurements document of the NKS project emergency management and radiation monitoring in nuclear and radiological accidents (EMARAD)

    Energy Technology Data Exchange (ETDEWEB)

    Lahtinen, J. [Radiation and Nuclear Safety Authority (STUK) (Finland)

    2006-04-15

    This report is one of the deliverables of the NKS Project Emergency management and radiation monitoring in nuclear and radiological accidents (EMARAD) (20022005). The project and the overall results are briefly described in the NKS publication 'Emergency Management and Radiation Monitoring in Nuclear and Radiological Accidents. Summary Report on the NKS Project EMARAD' (NKS-137, April 2006). In a nuclear or radiological emergency, all radiation measurements must be performed efficiently and the results interpreted correctly in order to provide the decision-makers with adequate data needed in analysing the situation and carrying out countermeasures. Managing measurements in different situations in a proper way requires the existence of pre-prepared emergency monitoring strategies. Preparing a comprehensive yet versatile strategy is not an easy task to perform because there are lots of different factors that have to be taken into account. The primary objective of this study was to discuss the general problematics concerning emergency monitoring strategies and to describe a few important features of an efficient emergency monitoring system as well as factors affecting measurement activities in practise. Some information concerning the current situation in the Nordic countries has also been included. (au)

  4. Emergency monitoring strategy and radiation measurements document of the NKS project emergency management and radiation monitoring in nuclear and radiological accidents (EMARAD)

    Energy Technology Data Exchange (ETDEWEB)

    Lahtinen, J. [Radiation and Nuclear Safety Authority (STUK) (Finland)

    2006-04-15

    This report is one of the deliverables of the NKS Project Emergency management and radiation monitoring in nuclear and radiological accidents (EMARAD) (20022005). The project and the overall results are briefly described in the NKS publication 'Emergency Management and Radiation Monitoring in Nuclear and Radiological Accidents. Summary Report on the NKS Project EMARAD' (NKS-137, April 2006). In a nuclear or radiological emergency, all radiation measurements must be performed efficiently and the results interpreted correctly in order to provide the decision-makers with adequate data needed in analysing the situation and carrying out countermeasures. Managing measurements in different situations in a proper way requires the existence of pre-prepared emergency monitoring strategies. Preparing a comprehensive yet versatile strategy is not an easy task to perform because there are lots of different factors that have to be taken into account. The primary objective of this study was to discuss the general problematics concerning emergency monitoring strategies and to describe a few important features of an efficient emergency monitoring system as well as factors affecting measurement activities in practise. Some information concerning the current situation in the Nordic countries has also been included. (au)

  5. First results of the research project MIRAMAR, Innovative Methodologies for Coastal Environmental Monitoring and Analysis

    Science.gov (United States)

    Rovere, A.; Casella, E.; Vacchi, M.; Mucerino, L.; Pedroncini, A.; Ferrari, M.; Firpo, M.

    2013-12-01

    A large part of the Mediterranean coastlines are strongly affected by coastal erosion. This is mainly due to human impact, natural hazards and their mutual interaction. All along the Regione Liguria coastlines (Northwestern Mediterranean), significant problems of coastal erosion are reported since the '60s. In this study, we focus on the coastal area between Albenga and Savona, where dramatic coastal retreat of ~2 m y-1 has been inferred from comparison of historic maps and older aerial pictures. Beach monitoring is essential in order to understand the mechanisms of evolution of soft coasts, and the rates of erosion. Traditional beach monitoring techniques involve topographic and bathymetric surveys of the emerged and submerged beach, and/or aerial photos repeated in time and compared through geographical information systems. A major problem of this kind of approach is the high economic cost. This often leads to increase the time lag between successive monitoring campaigns to reduce survey costs, with the consequence of fragmenting the information available for coastal zone management. MIRAMar is a project funded by Regione Liguria through the PO CRO European Social Fund, and it has two main objectives: i) to study and develop an innovative technique, relatively low-cost, to monitor the evolution of the shoreline using low-altitude Unmanned Aerial Vehicle (UAV) photos; ii) to study the impact of different type of storm events on a vulnerable coastal tract subject to coastal erosion using also the data collected by the UAV instrument. To achieve these aims we use a drone with its hardware and software suit, traditional survey techniques (bathymetric surveys, topographic GPS surveys and GIS techniques) and we implement a numerical modeling chain (coupling hydrodynamic, wave and sand transport modules) in order to study the impact of different type of storm events on a vulnerable coastal tract subject to coastal erosion. Aerial picture of one of the beaches studied

  6. Monitoring Based Commissioning: Benchmarking Analysis of 24 UC/CSU/IOU Projects

    Energy Technology Data Exchange (ETDEWEB)

    Mills, Evan; Mathew, Paul

    2009-04-01

    Buildings rarely perform as intended, resulting in energy use that is higher than anticipated. Building commissioning has emerged as a strategy for remedying this problem in non-residential buildings. Complementing traditional hardware-based energy savings strategies, commissioning is a 'soft' process of verifying performance and design intent and correcting deficiencies. Through an evaluation of a series of field projects, this report explores the efficacy of an emerging refinement of this practice, known as monitoring-based commissioning (MBCx). MBCx can also be thought of as monitoring-enhanced building operation that incorporates three components: (1) Permanent energy information systems (EIS) and diagnostic tools at the whole-building and sub-system level; (2) Retro-commissioning based on the information from these tools and savings accounting emphasizing measurement as opposed to estimation or assumptions; and (3) On-going commissioning to ensure efficient building operations and measurement-based savings accounting. MBCx is thus a measurement-based paradigm which affords improved risk-management by identifying problems and opportunities that are missed with periodic commissioning. The analysis presented in this report is based on in-depth benchmarking of a portfolio of MBCx energy savings for 24 buildings located throughout the University of California and California State University systems. In the course of the analysis, we developed a quality-control/quality-assurance process for gathering and evaluating raw data from project sites and then selected a number of metrics to use for project benchmarking and evaluation, including appropriate normalizations for weather and climate, accounting for variations in central plant performance, and consideration of differences in building types. We performed a cost-benefit analysis of the resulting dataset, and provided comparisons to projects from a larger commissioning 'Meta-analysis' database. A

  7. 2012 Groundwater Monitoring Report Project Shoal Area Subsurface Corrective Action Unit 447

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-03-01

    The Project Shoal Area (PSA) in Nevada was the site of a 12-kiloton underground nuclear test in 1963. Although the surface of the site has been remediated, investigation of groundwater contamination resulting from the test is still in the corrective action process. Annual sampling and hydraulic head monitoring are conducted at the site as part of the subsurface corrective action strategy. Analytical results from the 2012 monitoring are consistent with those of the previous years, with tritium detected only in well HC-4. The tritium concentration in groundwater from well HC-4 remains far below the U.S. Environmental Protection Agency-established maximum contaminant level of 20,000 picocuries per liter. Concentrations of total uranium and gross alpha were also detected during this monitoring period, with uranium accounting for nearly all the gross alpha activity. The total uranium concentrations obtained from this monitoring period were consistent with previous results and reflect a slightly elevated natural uranium concentration, consistent with the mineralized geologic terrain. Isotopic ratios of uranium also indicate a natural source of uranium in groundwater, as opposed to a nuclear-test-related source. Water level trends obtained from the 2012 water level data were consistent with those of previous years. The corrective action strategy for the PSA is currently focused on revising the site conceptual model (SCM) and evaluating the adequacy of the current monitoring well network. Some aspects of the SCM are known; however, two major concerns are the uncertainty in the groundwater flow direction and the cause of rising water levels in site wells west of the shear zone. Water levels have been rising in the site wells west of the shear zone since the first hydrologic characterization wells were installed in 1996. While water levels in wells west of the shear zone continue to rise, the rate of increase is less than in previous years. The SCM will be revised, and an

  8. On-line condition monitoring systems for high voltage circuit breakers : a collaborative research project 1997-2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    A three year field project was initiated to review and evaluate the state of the art in on-line conditioning monitoring technology for a high voltage (240 kV SF6) circuit breaker located at Dorsey Converter Station. The ELF breaker is a three independent pole design which allows for three separate monitoring systems. This project involved the installation of a different type of monitoring system on each phase and incorporated many types of transducers. Each monitoring system measured the same basic parameters including contact travel, 'a' and 'b' auxiliary contacts, phase currents, coil currents, heater and pump current, plus SF6/CF4 pressure and temperature. Over the entire monitoring period the breaker was operated over 700 times at rated voltage and an additional 300 times during maintenance. Temperature conditions ranged from -35 to +30 degrees C. The use of on-line monitoring provided many valuable results and enhanced the knowledge base for the apparatus under the test. It was determined that on-line monitoring of HV circuit breakers has potential, but installation has to be considered carefully. Monitoring systems can offer improvement in the understanding of how circuit breakers work and provide input into RCM programs. However, monitoring systems themselves are subject to failure and require maintenance and attention. 2 refs., 2 tabs., 7 figs.

  9. GULF OF MEXICO SEAFLOOR STABILITY AND GAS HYDRATE MONITORING STATION PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    J. Robert Woolsey; Thomas M. McGee; Robin C. Buchannon

    2004-11-01

    The gas hydrates research Consortium (HRC), established and administered at the University if Mississippi's Center for Marine Research and Environmental Technology (CMRET) has been active on many fronts in FY 03. Extension of the original contract through March 2004, has allowed completion of many projects that were incomplete at the end of the original project period due, primarily, to severe weather and difficulties in rescheduling test cruises. The primary objective of the Consortium, to design and emplace a remote sea floor station for the monitoring of gas hydrates in the Gulf of Mexico by the year 2005 remains intact. However, the possibility of levering HRC research off of the Joint Industries Program (JIP) became a possibility that has demanded reevaluation of some of the fundamental assumptions of the station format. These provisions are discussed in Appendix A. Landmark achievements of FY03 include: (1) Continuation of Consortium development with new researchers and additional areas of research contribution being incorporated into the project. During this period, NOAA's National Undersea Research Program's (NURP) National Institute for Undersea Science and Technology (NIUST) became a Consortium funding partner, joining DOE and Minerals Management Service (MMS); (2) Very successful annual and semiannual meetings in Oxford Mississippi in February and September, 2003; (3) Collection of piston cores from MC798 in support of the effort to evaluate the site for possible monitoring station installation; (4) Completion of the site evaluation effort including reports of all localities in the northern Gulf of Mexico where hydrates have been documented or are strongly suspected to exist on the sea floor or in the shallow subsurface; (5) Collection and preliminary evaluation of vent gases and core samples of hydrate from sites in Green Canyon and Mississippi Canyon, northern Gulf of Mexico; (6) Monitoring of gas activity on the sea floor, acoustically

  10. MMP-9和MMP-2基因多态性与原发性肝癌侵袭转移的关系%Correlation of MMP-9 and MMP-2 Gene SNPs with Hepatocellular Carcinoma Invasion and Metastasis

    Institute of Scientific and Technical Information of China (English)

    吴时胜; 邵立华; 李尚日; 张飞; 谢鸿; 张春秀; 刘桂平

    2012-01-01

    Objectlve To investigate the association between MMP-9 and MMP-2 gene SNPs of promoter regions and both infiltration and metastasis in hepatocellular carcinoma. Methods PCR- restriction fragment length polymorphism(PCR-RFLP) technique was applied to detect MMP-2 and MMP-9 promoter SNPs in 28 patients with hepatocellular carcinoma(8 cases with metastasis) and 42 healthy people. Results The risk of early metastasisof MMP-9-1562TT genotype was increased up to 1. 25-fold(95%CI,3. 64 ~ 5. 69),compared with MMP-9-1562CC or CT genotype,and irrelevant to the age or gender of patients. The risk of liver cancer in population harboring MMP-9-1562TT and MMP-2-1306CC or CT genotypes was significantly higher than in those harboring MMP-9-1562TT,MMP-2-t306CC or TT alone. Conclusion MMP-2-1306T/C polymorphism alone is not a risk factor of primary liver cancer,although has syn-ergistic interactions with MMP-9-1562C/T genotype, MMP-2 and MMP-9 gene polymorphism are related to the infiltration and metastasis of primary liver cancer.%目的 探讨原发性肝癌中MMP-9和MMP-2基因多态性表达与原发性肝癌侵袭转移的关系.方法 用聚合酶链反应—限制性片断长度多态性技术,检测MMP-2和MMP-9启动子基因型在28例原发性肝癌患者(其中8例有转移)和42例健康者中的频率.结果 与携带MMP-9- 1562CC和CT基因型相比,携带MMP-9- 1562TT基因型者早期发生侵袭转移的风险增加1.25倍(95%CI:3.64~5.69),且这种风险增高与研究对象的年龄和性别无关,同时携带MMP-9- 1562TT和MMP-2 - 1306CC或CT基因型的个体,惠肝癌的风险性较单一携带的个体显著增高(P<0.5).结论 MMP-2-1306T/C多态性单独与原发性肝癌风险无关,但与MMP-9- 1562C/T多态性可能有基因-基因交互作用.MMP-2和MMP-9基因多态性与原发性肝癌侵袭转移可能相关.

  11. 骨桥蛋白和MMP-2、MMP-9在鼻咽癌中的表达%Over Expression of Osteopontin and MMP-2 MMP-9 in Nasopharyngeal Carcinoma

    Institute of Scientific and Technical Information of China (English)

    赵冬梅; 李彩云; 于庆凯

    2010-01-01

    目的 探讨骨桥蛋白(OPN)和基质金属蛋白酶2、9(MMP-2、MMP-9)在鼻咽癌组织中的表达及其意义.方法 应用免疫组化二步法,分另别检测OPN和MMP-2、MMP-9在正常对照组(7例)和鼻咽癌(45例)组织中的表达,其中鼻咽癌患者发生颈部淋巴结转移有25例.结果 ①鼻咽癌组织中OPN和MMP-2、MMP-9的阳性率明显高于正常对照组(P<0.05),其中淋巴结转移组表达明显增高(P<0.05).②鼻咽癌中OPN和MMP-2、MMP-9的表达与肿瘤的淋巴结转移相关(P<0.05).结论 OPN和MMP-2、MMP-9可能在鼻咽癌的发生发展和突破基底膜向外扩散及淋巴结转移中起到重要作用.

  12. Study on the Role of MMP-2、MMP-9 in the Metastasis of Breast Cancer%MMP-2、MMP-9在乳腺癌转移中作用的研究

    Institute of Scientific and Technical Information of China (English)

    李治; 帅晓明; 黄韬

    2006-01-01

    目的:了解MMP-2、MMP-9与乳腺癌局部侵袭、淋巴结转移情况的相关性,进而探讨MMP-2、MMP-9在乳腺癌转移发生的作用.方法:用免疫组化染色的方法检测不同患者MMP-2、MMP-9的表达情况,然后进行相关性的分析研究.结果:MMP-2的表达情况与乳腺癌的局部侵袭情况存在显著的相关性(P<0.01),MMP-9的表达情况与乳腺癌的淋巴结转移情况存在显著的相关性(P<0.01).结论:我们认为MMP-2、MMP-9作为MMPs(基质金属蛋白酶家族)中的重要成员,在乳腺癌转移发生过程中有促进作用且作用不同.

  13. Collagenase-3 (MMP-13) expression in cutaneous malignant melanoma.

    Science.gov (United States)

    Corte, M D; Gonzalez, L O; Corte, M G; Quintela, I; Pidal, I; Bongera, M; Vizoso, F

    2005-01-01

    Matrix metalloproteases (MMPs), enzymes with the ability to degrade the extracellular matrix, play an important role in tissue invasion by cutaneous malignant melanoma (CMM). One specific MMP, collagenase-3 (MMP-13), is thought to have a key function in the activation of MMP. To evaluate the expression of MMP-13 in CMM and assess its possible relationship to clinical and pathological parameters. MMP-13 expression was analyzed in 51 paraffin-embedded tumor samples from patients with invasive CMM, ten samples from in situ melanomas, and in eight samples from benign lesions (three dermal melanocytic nevi, three compound melanocytic nevi and two atypical melanocytic nevi) using immunohistochemical techniques. The median follow-up period in patients with invasive CMM was 50 months. Benign lesions were consistently negative for MMP-13, whereas three of the ten in situ melanomas (30%) and 23 of the 51 invasive CMMs (45%) showed positive immunostaining for MMP-13. The percentage of MMP-13-positive tumors correlated significantly and positively with the mitotic index (p=0.002) in invasive CMM. However, our results did not show any significant association between tumoral MMP-13 expression and relapse-free survival in patients with invasive CMM. MMP-13 appears to be a factor associated with tumor aggressiveness in CMM. It seems to eliminate an important barrier not only against tumoral invasion but also against proliferation.

  14. Assessment of Dental Fluorosis in Mmp20+/− Mice

    Science.gov (United States)

    Sharma, R.; Tye, C.E.; Arun, A.; MacDonald, D.; Chatterjee, A.; Abrazinski, T.; Everett, E.T.; Whitford, G.M.; Bartlett, J.D.

    2011-01-01

    The molecular mechanisms that underlie dental fluorosis are poorly understood. The retention of enamel proteins hallmarking fluorotic enamel may result from impaired hydrolysis and/or removal of enamel proteins. Previous studies have suggested that partial inhibition of Mmp20 expression is involved in the etiology of dental fluorosis. Here we ask if mice expressing only one functional Mmp20 allele are more susceptible to fluorosis. We demonstrate that Mmp20+/− mice express approximately half the amount of MMP20 as do wild-type mice. The Mmp20 heterozygous mice have normal-appearing enamel, with Vickers microhardness values similar to those of wild-type control enamel. Therefore, reduced MMP20 expression is not solely responsible for dental fluorosis. With 50-ppm-fluoride (F−) treatment ad libitum, the Mmp20+/− mice had F− tissue levels similar to those of Mmp20+/+ mice. No significant difference in enamel hardness was observed between the F−-treated heterozygous and wild-type mice. Interestingly, we did find a small but significant difference in quantitative fluorescence between these two groups, which may be attributable to slightly higher protein content in the Mmp20+/− mouse enamel. We conclude that MMP20 plays a nominal role in dental enamel fluorosis. PMID:21386097

  15. Assessment of dental fluorosis in Mmp20 +/- mice.

    Science.gov (United States)

    Sharma, R; Tye, C E; Arun, A; MacDonald, D; Chatterjee, A; Abrazinski, T; Everett, E T; Whitford, G M; Bartlett, J D

    2011-06-01

    The molecular mechanisms that underlie dental fluorosis are poorly understood. The retention of enamel proteins hallmarking fluorotic enamel may result from impaired hydrolysis and/or removal of enamel proteins. Previous studies have suggested that partial inhibition of Mmp20 expression is involved in the etiology of dental fluorosis. Here we ask if mice expressing only one functional Mmp20 allele are more susceptible to fluorosis. We demonstrate that Mmp20 (+/-) mice express approximately half the amount of MMP20 as do wild-type mice. The Mmp20 heterozygous mice have normal-appearing enamel, with Vickers microhardness values similar to those of wild-type control enamel. Therefore, reduced MMP20 expression is not solely responsible for dental fluorosis. With 50-ppm-fluoride (F(-)) treatment ad libitum, the Mmp20 (+/-) mice had F(-) tissue levels similar to those of Mmp20 (+/+) mice. No significant difference in enamel hardness was observed between the F(-)-treated heterozygous and wild-type mice. Interestingly, we did find a small but significant difference in quantitative fluorescence between these two groups, which may be attributable to slightly higher protein content in the Mmp20 (+/-) mouse enamel. We conclude that MMP20 plays a nominal role in dental enamel fluorosis.

  16. Gelatinase B/MMP-9 in Tumour Pathogenesis and Progression

    Energy Technology Data Exchange (ETDEWEB)

    Farina, Antonietta Rosella; Mackay, Andrew Reay, E-mail: andrewreay.mackay@univaq.it [Department of Applied Clinical and Biotechnological Sciences, University of L’Aquila, Via Vetoio, Coppito 2, L’Aquila 67100 (Italy)

    2014-01-27

    Since its original identification as a leukocyte gelatinase/type V collagenase and tumour type IV collagenase, gelatinase B/matrix metalloproteinase (MMP)-9 is now recognised as playing a central role in many aspects of tumour progression. In this review, we relate current concepts concerning the many ways in which gelatinase B/MMP-9 influences tumour biology. Following a brief outline of the gelatinase B/MMP-9 gene and protein, we analyse the role(s) of gelatinase B/MMP-9 in different phases of the tumorigenic process, and compare the importance of gelatinase B/MMP-9 source in the carcinogenic process. What becomes apparent is the importance of inflammatory cell-derived gelatinase B/MMP-9 in tumour promotion, early progression and triggering of the “angiogenic switch”, the integral relationship between inflammatory, stromal and tumour components with respect to gelatinase B/MMP-9 production and activation, and the fundamental role for gelatinase B/MMP-9 in the formation and maintenance of tumour stem cell and metastatic niches. It is also apparent that gelatinase B/MMP-9 plays important tumour suppressing functions, producing endogenous angiogenesis inhibitors, promoting inflammatory anti-tumour activity, and inducing apoptosis. The fundamental roles of gelatinase B/MMP-9 in cancer biology underpins the need for specific therapeutic inhibitors of gelatinase B/MMP-9 function, the use of which must take into account and substitute for tumour-suppressing gelatinase B/MMP-9 activity and also limit inhibition of physiological gelatinase B/MMP-9 function.

  17. HIE ISOLDE Alignment and monitoring system technical design and project status

    CERN Document Server

    Gayde, J C; Kautzmann, G; Leclercq, Y; Waniorek, S; Williams, L

    2012-01-01

    In the frame of the HIE ISOLDE project most of the existing ISOLDE REX line will be replaced by a superconducting linac in order to upgrade the energy and intensity of the REX ISOLDE facility at CERN. Beam-physics simulations show that the optimum linac working conditions are obtained when the main axes of the active components, RF cavities and solenoid placed inside the cryostats, are aligned and permanently monitored on the REX Nominal Beam Line (NBL) within a precision of 0.3 mm for the cavities and 0.15 mm for the solenoids at one sigma level along directions perpendicular to the beam axis. This paper presents the proposed adjustment and alignment system based on opto-electronic sensors, optics and precise mechanic elements which are used, for some of them, in various non-standard environmental conditions such as high vacuum, cryogenic temperatures.

  18. Monitoring nuclear reactors with anti-neutrino detectors: the ANGRA project

    Energy Technology Data Exchange (ETDEWEB)

    Chimenti, Pietro; Leigui, Marcelo Augusto [UFABC - Universidade Federal do ABC. Rua Santa Adelia, 166. Bairro Bangu. Santo Andre - SP (Brazil); Anjos, Joao; Azzi, Gabriel; Rafael, Gama; Ademarlaudo, Barbosa; Lima, Herman; VAZ, Mario; Villar, Arthur [Centro Brasileiro de Pesquisas Fisicas - CBPF, Rua Dr. Xavier Sigaud, 150, Urca, Rio de Janeiro, RJ - 22290-180 (Brazil); Gonzales, Luis Fernando; Bezerra, Thiago; Kemp, Ernesto [Unicamp, State University of Campinas, Cidade Universitaria ' Zeferino Vaz' , Barao Geraldo - Campinas, Sao Paulo (Brazil); Nunokawa, Hiroshi [Department of Physics, Pontifical Catholic University - PUC, Rua Marques de Sao Vicente, 225, 22451-900 Gavea - Rio de Janeiro - RJ (Brazil); Guedes, Germano; Faria, Paulo Cesar [Universidade Estadual de Feira de Santana - UEFS, Avenida Transnordestina, Novo Horizonte (Brazil); Pepe, Iuri [Universidade Federal da Bahia - UFBA (Brazil)

    2010-07-01

    We describe the status of the ANGRA Project, aimed at developing an anti-neutrino detector for monitoring nuclear reactors. Indeed the detection of anti-neutrinos provides a unique handle for non-invasive measurements of the nuclear fuel. This kind of measurements are of deep interest for developing new safeguards tools which may help in nuclear non-proliferation programs. The ANGRA experiment, placed at about 30 m from the core of the 4 GW Brazilian nuclear power reactor ANGRA II, is based on a water Cherenkov detector with about one ton target mass. A few thousand antineutrino interactions per day are expected. The latest results from simulations and the status of the construction are presented. (authors)

  19. MMP-9 and MMP-2 activities in stomach and breast tumours, as measured by a novel MMP activity assay using modified urokinase as a substrate

    NARCIS (Netherlands)

    Hanemaaijer, R.; Visser, H.; Duffy, J.; Verspaget, H.W.; Verheijen, J.H.; Maguire, T.

    1998-01-01

    Matrix metalloproteinases (MMPs) play an important role in many pathological processes. However, MMP activities are difficult to determine since no simple specific and/or chromogenic substrates exist. Therefore, we have developed a novel MMP activity assay using a modified urokinase as a substrate.

  20. SAR interferometry monitoring along the ancient Rome City Walls -the PROTHEGO project case study

    Science.gov (United States)

    Carta, Cristina; Cimino, Maria gabriella; Leoni, Gabriele; Marcelli, Marina; Margottini, Claudio; Spizzichino, Daniele

    2017-04-01

    Led by the Italian Institute for Environmental Protection and Research, in collaboration with NERC British Geological Survey, Geological and Mining Institute of Spain, University of Milano-Bicocca and Cyprus University of Technology, the PROTHEGO project, co-funded in the framework of JPI on Cultural Heritage EU program (2015-2018), brings an innovative contribution towards the analysis of geo-hazards in areas of cultural heritage in Europe. The project apply InSAR techniques to monitor monuments and sites that are potentially unstable due to natural geo-hazard. After the remote sensing investigation, detailed geological interpretation, hazard analysis, local-scale monitoring, advanced modeling and field surveying for some case studies is implemented. The selected case studies are: the Alhambra in Granada (ES); the Choirokoitia village (CY); the Derwent Valley Mills (UK); the Pompei archaeological site and Historical centre of Rome (IT). In this work, in particular, we will focus on ground deformation measurements (obtained by satellite SAR Interferometry) and on their interpretation with respect to the ancient Rome City Walls. The research activities carried out jointly with the Superintendence's technicians, foresee the implementation of a dedicated web GIS platform as a final repository for data storage and spatial data elaboration. The entire circuit of the ancient city walls (both Mura Aureliane and Mura Gianicolensi), was digitalized and georeferenced. All the elements (towers, gates and wall segments) were drawn and collected in order to produce a map of elements at risk. A detailed historical analysis (during the last twenty years) of the ground and structural deformations were performed. A specific data sheet of ruptures was created and fulfilled in order to produce a geographic inventory of past damage. This data sheet contains the following attributes: triggering data; typology of damage; dimension, triggering mechanism; presence of restoration works

  1. Cadmium exposure inhibits MMP2 and MMP9 activities in the prostate and testis

    Energy Technology Data Exchange (ETDEWEB)

    Lacorte, Livia M.; Rinaldi, Jaqueline C.; Justulin, Luis A.; Delella, Flávia K. [Univ Estadual Paulista – UNESP, Institute of Biosciences, Department of Morphology, Extracellular Matrix Laboratory, Botucatu, SP (Brazil); Moroz, Andrei [Univ Estadual Paulista – UNESP, School of Pharmaceutical Sciences, Department of Bioprocess and Biotechnology, Cell Culture Laboratory, Araraquara, SP (Brazil); Felisbino, Sérgio L., E-mail: felisbin@ibb.unesp.br [Univ Estadual Paulista – UNESP, Institute of Biosciences, Department of Morphology, Extracellular Matrix Laboratory, Botucatu, SP (Brazil)

    2015-02-20

    Matrix metalloproteinases (MMPs) are zinc (Zn{sup 2+}) and calcium (Ca{sup 2+}) dependant endopeptidases, capable of degradation of numerous components of the extracellular matrix. Cadmium (Cd{sup 2+}) is a well known environmental contaminant which could impair the activity of MMPs. In this sense, this study was conducted to evaluate if Cd{sup 2+} intake inhibits these endopeptidases activities at the rat prostate and testicles and if it directly inhibits the activity of MMP2 and MMP9 at gelatinolytic assays when present in the incubation buffer. To investigate this hypothesis, Wistar rats (5 weeks old), were given tap water (untreated, n = 9), or 15 ppm CdCl{sub 2} diluted in drinking water, during 10 weeks (n = 9) and 20 weeks (n = 9). The animals were euthanized and their ventral prostate, dorsal prostate, and testicles were removed. These tissue samples were processed for protein extraction and subjected to gelatin zymography evaluation. Additionally, we performed an experiment of gelatin zymography in which 5 μM or 2 mM cadmium chloride (CdCl{sub 2}) was directly dissolved at the incubation buffer, using the prostatic tissue samples from untreated animals that exhibited the highest MMP2 and MMP9 activities in the previous experiment. We have found that CdCl{sub 2} intake in the drinking water led to the inhibition of 35% and 30% of MMP2 and MMP9 (p < 0.05) at the ventral prostate and testis, respectively, in Cd{sup 2+} treated animals when compared to controls. Moreover, the activities of the referred enzymes were 80% and 100% inhibited by 5 μM and 2 mM of CdCl{sub 2}, respectively, even in the presence of 10 mM of CaCl{sub 2} within the incubation buffer solution. These important findings demonstrate that environmental cadmium contamination may deregulate the natural balance in the extracellular matrix turnover, through MMPs downregulation, which could contribute to the toxic effects observed in prostatic and testicular tissue after its

  2. Pilot CCS project in Indonesia "Gundih CCS project": Geological and geophysical surveys for site selection and monitoring

    Science.gov (United States)

    Tsuji, Takeshi; Matsuoka, Toshifumi; Takahashi, Toru; Kitamura, Keigo; Onishi, Kyosuke; Yamada, Yasuhiro; Rachmat Sule, Mohammad; Kadir, Wawan Gunawan A.; Widarto, Djedi S.; Sebayang, Rio I.; Prasetyo, Agung; Priyono, Awali; Widianto, Eko; Sapiie, Benyamin

    2013-04-01

    A pilot CCS project in Indonesia will be implemented in Gundih area, Central Java Province. The Gundih area is a gas field, and gas is ready to be produced by Pertamina EP. The CO2 content within the produced gas is more than 20% in the Gundih field, so that CO2 injection near the gas production well could be effective way to avoid abundant CO2 emission. Before implementing CO2 injection, the reservoir for CO2 injection must be characterized carefully by conducting subsurface characterization and evaluation, in order to make sure that the reservoir is suitable for CCS. Here we report preliminary results of site surveys for the determination of CO2 injection site in the Gundih area. Subsurface structures imaged on seismic reflection profiles indicate that the Ngrayong formation is one of the candidates for CO2 injection. The lithology of the Ngrayong formation is sandstone, and the depth of the formation is ~1 km in the Gundih area. Since we could not find large-scale structural closure (i.e., anticline) for the Ngrayong formation, we need to consider residual trapping. To reveal hydrological properties (e.g., permeability) of the Ngrayong formation, we obtained rock samples from the outcrop of the Ngrayong formation. Using the laboratory-derived hydrological properties and subsurface structures extracted from seismic data (e.g., geometry of the Ngrayong formation), we will apply reservoir simulation in order to determine CO2 injection site. To design the geophysical monitoring survey (e.g., receiver and source position in time-lapse seismic survey), furthermore, we conduct simulation study for the constructed geological model and estimate elastic and electric responses associated with CO2 injection.

  3. Project of a Near-Real-Time Sismo-acoustic Submarine Station for offshore monitoring (NRTSSS)

    Science.gov (United States)

    D'Anna, G.; Calore, D.; Mangano, G.; D'Alessandro, A.; Favali, P.

    2011-12-01

    The INGV seismic network ensures reliable and continuous monitoring of the Italian territory. However, the peculiarity of the Italian peninsula, characterised by an intense offshore geodynamic and seismic activity, requires the extension of the seismic monitoring to the sea. The aim of this project is: - to identify bottleneck is related to the construction, installation and use of underwater seismic station; - to define the most appropriate and low-cost architecture to guarantee the minimum functionality required for a seismic station. In order to obtain reliable seafloor seismic signals integrated to land-based network, the requirements to be fulfill are: - an acceptable coupling with the seabed; - the orientation of the components with respect to the magnetic North and to the verticality; - the correct time stamp of the data; - the data transfer to the land for the integration. Currently, the optimal solution for offshore seismic station is a cable connection to power and real-time data transfer, like the case of Western Ionian Sea cabled observatory, one of the operative node of the EMSO research infrastructure (European Multidisciplinary Seafloor and water column Observatory, http://emso-eu.org). But in the Mediterranean many seismic areas are located a few tens-hundreds of miles from the coast and cabled solutions are not feasible essentially for economic reasons. For this kind of installations EMSO research infrastructure foresees no-cabled solution, that requires a surface buoy deployed in the vicinity seafloor modules.This project plans to develop a surface buoy equipped with autonomous power supply system to power also the seafloor platforms and two-way communication system enabling the data transfer through latest generation of broadband radio communication or satellite link (Fig. 1). All the components of the prototype system are described.

  4. A study on the expression level of IL-10 and MMP-P in non-small cell lung cancer and their correlation with prognosis%非小细胞肺癌组织中IL-10、MMP-9的表达水平的初步研究及预后相关性分析

    Institute of Scientific and Technical Information of China (English)

    葛海波

    2011-01-01

    status are related to prognosis of NSCLC, and the high expression of IL-10 and low expression of MMP-9 may have an impact on the prognosis of NSCLC. Conclusion The expression of IL-10 and MMP-9 were impact factors of NSCLC. TNM staging/IL-10/MMP-9 expression were independent prognostic impact factors of NSCLC. High expression of IL-10 and low expression of MMP-9 were independent factors. IL-10 may inhibit metastasis of tumor cells by inhibiting the expression of MMP-9. Therefore, it may play an important role to assess the prognosis of NSCLC patients by monitoring the expression of IL-10 and MMP-9.

  5. Land change monitoring, assessment, and projection (LCMAP) revolutionizes land cover and land change research

    Science.gov (United States)

    Young, Steven

    2017-05-02

    When nature and humanity change Earth’s landscapes - through flood or fire, public policy, natural resources management, or economic development - the results are often dramatic and lasting.Wildfires can reshape ecosystems. Hurricanes with names like Sandy or Katrina will howl for days while altering the landscape for years. One growing season in the evolution of drought-resistant genetics can transform semiarid landscapes into farm fields.In the past, valuable land cover maps created for understanding the effects of those events - whether changes in wildlife habitat, water-quality impacts, or the role land use and land cover play in affecting weather and climate - came out at best every 5 to 7 years. Those high quality, high resolution maps were good, but users always craved more: even higher quality data, additional land cover and land change variables, more detailed legends, and most importantly, more frequent land change information.Now a bold new initiative called Land Change Monitoring, Assessment, and Projection (LCMAP) promises to fulfill that demand.Developed at the U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) Center in Sioux Falls, South Dakota, LCMAP provides definitive, timely information on how, why, and where the planet is changing. LCMAP’s continuous monitoring process can detect changes as they happen every day that Landsat satellites acquire clear observations. The result will be to place near real-time information in the hands of land and resource managers who need to understand the effects these changes have on landscapes.

  6. Correlation Between Th1, Th2 Cells and Levels of Serum MMP-2, MMP-9 in Children with Asthma

    Directory of Open Access Journals (Sweden)

    Xuan WANG

    2015-12-01

    Full Text Available Abstract Objective: To explore the correlation between Th1 and Th2 cells and the levels of serum matrix metalloproteinase-2 (MMP-2 and MMP-9 in children with asthma. Methods: A total of 89 children with asthma were divided into acute group (n=48 and chronic group (n=41 according to the course of disease, and 40 healthy children at the same term were collected as control group. The ratios of Th1 and Th2 cells as well as levels of MMP-2 and MMP-9 were compared in three groups, and the correlation between Th1 and Th2 cells and levels of MMP-2, MMP-9 was analyzed in acute group and chronic group. Results: When compared with control group, the ratios of Th1 and Th2 cells went down in both acute group and chronic group (P<0.01, while the levels of serum MMP-2 and MMP-9 up (P<0.01. The levels of serum MMP-2 and MMP-9 in acute group were dramatically higher than those in chronic group, and there was statistical significance (P<0.01. Pearson correlation analysis revealed that there was no significant correlation between Th1 and Th2 cells and MMP-2 level (r=0.148, P=0.314, r=0.299, P=0.058; r=0.183, P=0.214, r=0.289, P=0.067, whereas both Th1 and Th2 cells were negatively correlated with MMP-9 level in acute group and chronic group (r=-0.489, P=0.000, r=-0.324, P=0.039; r=-0.352, P=0.014, r=-0.357, P=0.022. Conclusion: Aberrant secretion of Th cells can not only damage the immune function of children with asthma, but also decrease the level of serum MMP-9, consequently affecting the collagen degradation and airway remodeling.

  7. Methodology for locale-scale monitoring for the PROTHEGO project: the Choirokoitia case study

    Science.gov (United States)

    Themistocleous, Kyriacos; Agapiou, Athos; Cuca, Branka; Danezis, Chris; Cigna, Francesca; Margottini, Claudio; Spizzichino, Daniele

    2016-10-01

    PROTHEGO (PROTection of European Cultural HEritage from GeO-hazards) is a collaborative research project funded in the framework of the Joint Programming Initiative on Cultural Heritage and Global Change (JPICH) - Heritage Plus in 2015-2018 (www.prothego.eu). PROTHEGO aims to make an innovative contribution towards the analysis of geohazards in areas of cultural heritage, and uses novel space technology based on radar interferometry (InSAR) to retrieve information on ground stability and motion in the 400+ UNESCO's World Heritage List monuments and sites of Europe. InSAR can be used to measure micro-movements to identify geo-hazards. In order to verify the InSAR image data, field and close range measurements are necessary. This paper presents the methodology for local-scale monitoring of the Choirokoitia study site in Cyprus, inscribed in the UNESCO World Heritage List, and part of the demonstration sites of PROTHEGO. Various field and remote sensing methods will be exploited for the local-scale monitoring, static GNSS, total station, leveling, laser scanning and UAV and compared with the Persistent Scatterer Interferometry results. The in-situ measurements will be taken systematically in order to document any changes and geo-hazards that affect standing archaeological remains. In addition, ground truth from in-situ visits will provide feedback related to the classification results of urban expansion and land use change maps. Available archival and current optical satellite images will be used to calibrate and identify the level of risk at the Cyprus case study site. The ground based geotechnical monitoring will be compared and validated with InSAR data to evaluate cultural heritage sites deformation trend and to understand its behaviour over the last two decades.

  8. Visualizing Earth Science Data for Environmental Monitoring and Decision Support in Mesoamerica: The SERVIR Project

    Science.gov (United States)

    Hardin, D.; Graves, S.; Sever, T.; Irwin, D.

    2005-05-01

    In 2002 and 2003 NASA, the World Bank and the United States Agency for International Development (USAID) joined with the Central American Commission for Environment and Development (CCAD) to develop an advanced decision support system for Mesoamerica (named SERVIR). Mesoamerica - composed of the seven Central American countries and the five southernmost states of Mexico - makes up only a small fraction of the world's land surface. However, the region is home to approximately eight percent of the planet's biodiversity (14 biosphere reserves, 31 Ramsar sites, 8 world heritage sites, 589 protected areas) and 45 million people including more than 50 different ethnic groups. Mesoamerica's biological and cultural diversity are severely threatened by human impact and natural disasters including extensive deforestation, illegal logging, water pollution, slash and burn agriculture, earthquakes, hurricanes, drought, and volcanic eruption. NASA Marshall Space Flight Center (NASA/MSFC), together with the University of Alabama in Huntsville (UAH) and the SERVIR partners are developing state-of-the-art decision support tools for environmental monitoring as well as disaster prevention and mitigation in Mesoamerica. These partners are contributing expertise in space-based observation with information management technologies and intimate knowledge of local ecosystems to create a system that is being used by scientists, educators, and policy makers to monitor and forecast ecological changes, respond to natural disasters, and better understand both natural and human induced effects. The decision support and environmental monitoring data products are typically formatted as conventional two-dimensional, static and animated imagery. However, in addition to conventional data products and as a major portion of our research, we are employing commercial applications that generate three-dimensional interactive visualizations that allow data products to be viewed from multiple angles and at

  9. Chicago Clean Air, Clean Water Project: Environmental Monitoring for a Healthy, Sustainable Urban Future

    Energy Technology Data Exchange (ETDEWEB)

    none, none; Tuchman, Nancy [Institute of Environmental Sustainability (IES), Chicago, IL (United States)

    2015-11-11

    The U.S. Department of Energy awarded Loyola University Chicago and the Institute of Environmental Sustainability (IES) $486,000.00 for the proposal entitled “Chicago clean air, clean water project: Environmental monitoring for a healthy, sustainable urban future.” The project supported the purchase of analytical instruments for the development of an environmental analytical laboratory. The analytical laboratory is designed to support the testing of field water and soil samples for nutrients, industrial pollutants, heavy metals, and agricultural toxins, with special emphasis on testing Chicago regional soils and water affected by coal-based industry. Since the award was made in 2010, the IES has been launched (fall 2013), and the IES acquired a new state-of-the-art research and education facility on Loyola University Chicago’s Lakeshore campus. Two labs were included in the research and education facility. The second floor lab is the Ecology Laboratory where lab experiments and analyses are conducted on soil, plant, and water samples. The third floor lab is the Environmental Toxicology Lab where lab experiments on environmental toxins are conducted, as well as analytical tests conducted on water, soil, and plants. On the south end of the Environmental Toxicology Lab is the analytical instrumentation collection purchased from the present DOE grant, which is overseen by a full time Analytical Chemist (hired January 2016), who maintains the instruments, conducts analyses on samples, and helps to train faculty and undergraduate and graduate student researchers.

  10. Monitoring Liquid Argon Time Projection Chambers With A Raspberry Pi Camera

    Science.gov (United States)

    Patteson, Crystal

    2016-03-01

    The MicroBooNE detector is the first of three liquid argon (LAr) time projection chambers (TPCs) that are central to the short-baseline neutrino program at Fermilab. These chambers consist of thousands of stainless steel or beryllium-copper sense wires that detect ionization electrons produced when neutrinos interact with liquid argon nuclei inside the detector. The wires are several hundred microns in diameter to several meters in length. The construction of such LAr TPCs often takes place in an assembly hall, which is different from the detector hall where the experiment will operate, as was the case with MicroBooNE. Since in situ access to the chamber and its wires in the beamline enclosure can be limited, we investigate the possibility of using a Raspberry Pi single-board computer connected to a low-cost camera installed inside the cryostat as a cost-efficient way to verify the integrity of the wires after transport. We also highlight other benefits of this monitoring device implemented in MicroBooNE, including detector hall surveillance and verification of the status of LED indicators on detector electronics. The author would like to thank Dr. Matthew Toups for his encouragement and guidance on this research project.

  11. Overview of the IEA GHG Weyburn-Midale CO{sub 2} monitoring and storage project

    Energy Technology Data Exchange (ETDEWEB)

    Mourits, Frank [Natural Resources Canada (Canada)

    2008-07-15

    In this presentation it is explained what the Weyburn-Midale project consists of; it is also spoken on the operation for the enhanced oil recovery of Encana Weyburn and Apache Midale Commercial; an overview and results are given of phase I (2000-2004) of the Weyburn project of monitoring and CO{sub 2} storage of greenhouse effect gases of the International Energy Agency; Characteristics and statistics of operation of the oil fields Weyburn and Midale, and how is it that with CO{sub 2} and recycled water the oil is recovered?. [Spanish] En esta presentacion se explica en que consiste el proyecto Weyburn-Midale; se habla tambien sobre la operacion para la recuperacion mejorada de petroleo de Encana Weyburn y Apache Midale Commercial; se da una vision general y resultados de la fase I (2000-2004) del proyecto Weyburn de monitoreo y almacenamiento de CO{sub 2} gases de efecto invernadero de la Agencia Internacional de Energia; Caracteristicas y estadisticas de operacion de los yacimientos petroliferos Weyburn y Midale, y como es que con el CO{sub 2} y agua reciclada se recupera el petroleo?.

  12. Expressions of MMP-2 and MMP-9 during wound healing in rat skin%MMP-2、MMP-9在大鼠皮肤创面愈合过程中的表达

    Institute of Scientific and Technical Information of China (English)

    夏云; 张利远; 徐斌; 陈静; 陈淼

    2012-01-01

    Objective To investigate dynamic changes of metalloproteinase-2 (MMP-2) and MMP-9 expressions during wound healing in rat skin and their correlation. Methods Forty-two rats were used to establish dorsal skin wounds model and equally randomized into seven groups according to the times when the biopsies from skin wounds were harvested at 1,12,24 hours and 3,7,14,21 days after wounds formation, respectively. The other 3 rats were taken as the controls. The expressions of MMP-2 and MMP-9 in the samples were detected by immunohistochemistry. Results MMP-2 and MMP-9 were hardly expressed in normal skins of the control rats. The expression of MMP-2 increased gradually after injury and reached the peak on the 14th day,then decreased gradually to a certain level. The expression of MMP-9 increased rapidly and showed a high level from 24 hours to 7 days after injury, then decreased gradually to a low level. The expression level of MMP-2 was positively correlated to that of MMP-9 at 12 hours and 3,7,14,21 days and negatively correlated at 24 hours after injury. Conclusion The MMP-2 and MMP-9 expressions have certain rule and influence each other during wound healing in rats.%目的 探讨基质金属蛋白酶2 (MMP-2)、MMP-9在大鼠皮肤创面愈合过程中表达的动态及其相关性.方法 42只大鼠制作大鼠背部皮肤创面模型后按取创面皮肤时间随机均分为七组,即在创面形成后1、12、24 h及3、7、14、21d切取背部皮肤创面标本,采用免疫组化法检测标本中MMP-2及MMP-9的表达.另取3只正常大鼠背部皮肤标本作为对照.结果 正常大鼠皮肤中MMP-2、MMP-9几无表达;背部皮肤创面形成后,MMP-2逐渐升高,14 d达峰,21 d仍高于正常水平;MMP-9迅速升高,在24 h-7 d呈高水平表达,后逐渐降至较低水平;MMP-2与MMP-9的表达水平在12h,3、7、14、21d时呈正相关,在24 h时呈负相关.结论 在大鼠创面愈合过程中MMP-2和MMP-9的表达有一定规律,并且二者相互影响.

  13. MMP-2、MMP-9及EMMPRIN在子宫内膜异位症中的表达及临床意义%Expression and significance of MMP-2, MMP-9 and VEGF in endometriosis

    Institute of Scientific and Technical Information of China (English)

    车建华; 潘文婧; 刘倩; 谭文华

    2011-01-01

    Objective: To investigate the expression and significance of EMMPRIN, MMP - 2 and MMP - 9 in endometriosis (Ems). Methods: The expression of MMP - 2, MMP - 9 and EMMPRIN in 42 cases of ectopic endometrium, 42 cases of eutopic en-dometrial and 20 cases of normal endometrium were detected by two - step immunohistochemical method, then the correlation of the expression of them was evaluated. Results: The MMP - 2, MMP - 9 and EMMPRIN positive expression rate was 95. 24%、 92. 86% and 90. 48% respectively in the ectopic endometrium group, which were significantly higher than their counterparts in the eutopic endorae-trial group and the normal endometrium group ( P < 0. 05 ) ; there was not significant difference between the eutopic endometrial group and the normal endometrium group. The expression of EMMPRIN protein was positively correlated with MMP - 2, 9 in the ectopic endometrium group (P <0. 01). Conclusion; EMMPRIN, MMP - 2 and MMP -9 are all involved in the process of invasionand tissue remodeling, which is supposed to be part of pathogenesis of endometriosis and EMMPRIN protein plays its role probably through activating MMP - 2, 9 synthesis and secretion.%目的 研究基质金属蛋白酶2(MMP-2)、基质金属蛋白酶9(MMP-9)、细胞外基质金属蛋白酶诱导因子(EMMPRIN)在子宫内膜异位症(EMs)的表达和意义.方法 应用免疫组化二步法检测EMs患者异位内膜42例、在位内膜42例及正常内膜20例中的MMP-2、MMP-9、EMMPRIN的表达情况,并对它们的EMMPRIN、MMP-2、MMP-9蛋白表达水平进行相关性分析.结果 MMP-2、MMP-9、EMMPRIN在异位内膜组中阳性表达率分别为95.24%、92.86%和90.48%,显著高于在位内膜组、正常内膜组(P<0.05);而在位内膜组和正常内膜组差异无统计学意义(P>0.05).异位内膜组中,EMMPRIN分别和MMP-2,MMP-9呈正相关性(P<0.01).结论 MMP-2、MMP-9、EMMPRIN共同参与了子宫内膜异位症的发生发展;EMMPRIN可能通过促进MMP

  14. Global Radiological Source Sorting, Tracking, and Monitoring Project: Phase I Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Walker, Randy M [ORNL; Hill, David E [ORNL; Gorman, Bryan L [ORNL

    2010-09-01

    As a proof of concept tested in an operational context, the Global Radiological Source Sorting, Tracking, and Monitoring (GRadSSTraM) Project successfully demonstrated that radio frequency identification (RFID) and Web 2.0* technologies can be deployed to track controlled shipments between the United States and the European Union. Between November 2009 and May 2010, a total of 19 shipments were successfully shipped from Oak Ridge National Laboratory (ORNL) by the U.S. Postal Service (USPS) and tracked to their delivery at England's National Physical Laboratory (NPL) by the United Kingdom Royal Mail. However, the project can only be viewed as a qualified success as notable shortcomings were observed. Although the origin and terminus of all RFID-enabled shipments were recorded and no shipments were lost, not all the waypoints between ORNL and NPL were incorporated into the pilot. Given limited resources, the project team was able to install RFID listeners/actuators at three waypoints between the two endpoints. Although it is likely that all shipments followed the same route between ORNL and NPL, it cannot be determined beyond question that all 19 shipments were routed on identical itineraries past the same three waypoints. The pilot also raises the distinct possibility that unattended RFID tracking alone, without positive confirmation that a tagged item has been properly recorded by an RFID reader, does not meet a rigorous standard for shipping controlled items. Indeed, the proof of concept test strongly suggests that a multifaceted approach to tracking may be called for, including tracking methods that are capable of reading and accepting multiple inputs for individual items [e.g., carrier-provided tracking numbers, Universal Product Codes (UPCs), and RFID tags]. For controlled items, another apparent requirement is a confirmation feature, human or otherwise, which can certify that an item's RFID tag, UPC, or tracking number has been recorded.

  15. Expressions of MMP-2 and MMP-9 in the Esophageal Squamous-celled Carcinoma%食管鳞癌组织中MMP-2和MMP-9的表达及临床意义

    Institute of Scientific and Technical Information of China (English)

    曹婧

    2016-01-01

    目的 探讨食管鳞癌组织中基质金属蛋白酶-2(MMP-2)和MMP-9的表达及临床意义.方法 采用免疫组化S-P法检测105例食管鳞癌和50例癌旁正常食管黏膜组织中MMP-2和MMP-9的表达.结果 食管鳞癌组织中MMP-2和MMP-9的阳性率分别为76.2%(80/105)、71.4% (75/105),癌旁正常食管黏膜组织中分别为6.0% (3/50)、8.0%(4/50),比较差异均有统计学意义( P均<0.05).食管鳞癌组织中MMP-2和MMP-9的表达与分化程度、浸润纤维膜与否、临床分期、淋巴结转移与否有关(P均<0.05).食管鳞癌组织中MMP-2和MMP-9的表达呈正相关关系(r=0.438,P<0.05).结论 MMP-2和MMP-9在食管鳞癌组织中均存在高表达,这与食管癌的疾病进展关系密切.

  16. MMP-2、MMP-7蛋白在胃癌组织中表达的意义%The significance of MMP-2 and MMP-7 protein expression in human gastric carcinoma

    Institute of Scientific and Technical Information of China (English)

    潘留兰; 鲍晓蕾; 陈永胜; 王艳芬; 娄燕

    2007-01-01

    目的 探讨基质金属蛋白酶MMP-2、MMP-7在胃癌组织中的表达、侵袭及转移的关系.方法 应用免疫组化SP法检测87例胃癌组织、癌旁组织及正常胃组织中MMP-2、MMP-7的表达情况.结果 MMP-2、MMP-7在正常胃组织表达率为阴性,在癌旁组织中有低表达,分别为18.4%、21.8%,在胃癌组织中表达率明显增高,且表达率的高低与淋巴结转移、分化程度、浸润程度呈密切相关性(P<0.05).且MMP-2、MMP-7在胃癌组织中表达具有相关性.结论 MMP-2、MMP-7在胃癌组织中的高表达且两者呈正相关,并对胃癌的预后判定有一定意义.

  17. Macrophage migration and invasion is regulated by MMP10 expression.

    Directory of Open Access Journals (Sweden)

    Megan Y Murray

    Full Text Available This study was designed to identify metalloproteinase determinants of macrophage migration and led to the specific hypothesis that matrix metalloproteinase 10 (MMP10/stromelysin-2 facilitates macrophage migration. We first profiled expression of all MMPs in LPS-stimulated primary murine bone marrow-derived macrophages and Raw264.7 cells and found that MMP10 was stimulated early (3 h and down-regulated later (24 h. Based on this pattern of expression, we speculated that MMP10 plays a role in macrophage responses, such as migration. Indeed, using time lapse microscopy, we found that RNAi silencing of MMP10 in primary macrophages resulted in markedly reduced migration, which was reversed with exogenous active MMP10 protein. Mmp10 (-/- bone marrow-derived macrophages displayed significantly reduced migration over a two-dimensional fibronectin matrix. Invasion of primary wild-type macrophages into Matrigel supplemented with fibronectin was also markedly impaired in Mmp10 (-/- cells. MMP10 expression in macrophages thus emerges as an important moderator of cell migration and invasion. These findings support the hypothesis that MMP10 promotes macrophage movement and may have implications in understanding the control of macrophages in several pathologies, including the abnormal wound healing response associated with pro-inflammatory conditions.

  18. Detection and the clinical significance of serum MMP-2、MMP-3、MMP-9 and TIMP-4 levels in patients with systemic lupus erythematosus%系统性红斑狼疮患者外周血MMP-2、MMP-3、MMP-9和TIMP-4水平的检测及其临床意义

    Institute of Scientific and Technical Information of China (English)

    胡亮; 彭奕冰; 王学锋; 巩惠芸

    2012-01-01

    目的:检测系统性红斑狼疮(SLE)患者外周血基质金属蛋白酶(MMP)-2、MMP-3、MMP-9和基质金属蛋白酶组织型抑制因子(TIMP)-4的水平,并探讨其临床意义.方法:采用双抗夹心ELISA法,检测58例SLE患者及30例正常对照者的血清MMP-2、MMP-3、MMP-9和TIMP-4水平.结果:SLE患者血清MMP-3、TIMP-4水平显著高于正常对照者,但其血清MMP-2、MMP-9水平则与正常对照者间无统计学差异.SLE患者的血清MMP-3水平与MMP-2、MMP-9、TIMP-4水平均呈正相关,MMP-9水平与MMP-2水平间亦呈正相关;同时其MMP-2、MMP-3、MMP-9水平与反映肾脏、肝脏及机体免疫状态的多组指标间存在相关性,包括尿素氮、肌酐、尿酸、白蛋白、免疫球蛋白G、免疫球蛋白A、免疫球蛋白M、补体C3和补体C4等;SLE患者中,发生血小板减少者的血清MMP-2、MMP-9水平与血小板正常者相比显著降低.结论:SLE患者外周血MMP-3和TIMP-4水平显著升高.不同MMP间可相互调节,同时也受TIMP-4等TIMP的调节.MMP-2、MMP-3和MMP-9可能参与了SLE患者肾脏和肝脏的病理损害过程.%Objective To detect serum matrix metalloproteinase (MMP)-2, MMP-3, MMP-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-4 levels in patients with systemic lupus erythematosus (SLE) and define its clinical significance. Methods Serum levels of MMP-2, MMP-3, MMP-9 and TIMP-4 were measured by ELISA. Results Levels of MMP-3 and TIMP-4 were significantly higher in SLE patients than those in healthy controls. Positive correlation was found between these MMPs. Serum MMP-2, MMP-3, MMP-9 levels had a correlation with other laboratory results reflecting the condition of kidney, liver and immunity. MMP-2 and MMP-9 levels were decreased in SLE patients having a low platelet count. Conclusins Serum MMP-2 and TIMP-4 levels are significantly higher in patients with SLE. MMP-2, MMP-3 and MMP-9 were regulated by a complicated network. TIMP-4 is involved in this

  19. MMP-1 and MMP-9 regulate epidermal growth factor-dependent collagen loss in human carotid plaque smooth muscle cells.

    Science.gov (United States)

    Rao, Velidi H; Kansal, Vikash; Stoupa, Samantha; Agrawal, Devendra K

    2014-02-01

    Mechanisms underlying the rupture of atherosclerotic plaque, a crucial factor in the development of myocardial infarction and stroke, are not well defined. Here, we examined the role of epidermal growth factor (EGF)-mediated matrix metalloproteinases (MMP) on the stability of interstitial collagens in vascular smooth muscle cells (VSMCs) isolated from carotid endarterectomy tissues of symptomatic and asymptomatic patients with carotid stenosis. VSMCs isolated from the carotid plaques of both asymptomatic and symptomatic patients were treated with EGF. The MMP-9 activity was quantified by gelatin zymography and the analysis of mRNA transcripts and protein for MMP-9, MMP-1, EGFR and collagen types I, Col I(α1) and collagen type III, Col III(α1) were analyzed by qPCR and immunofluorescence, respectively. The effect of EGF treatment to increase MMP-9 activity and mRNA transcripts for MMP-9, MMP-1, and EGFR and to decrease mRNA transcripts for Col I(α1) and Col III(α1) was threefold to fourfold greater in VSMCs isolated from the carotid plaques of symptomatic than asymptomatic patients. Inhibitors of EGFR (AG1478) and a small molecule inhibitor of MMP-9 decreased the MMP9 expression and upregulated Col I(α1) and Col III(α1) in EGF-treated VSMCs of both groups. Additionally, the magnitude in decreased MMP-9 mRNA and increased Col I(α1) and Col III(α1) due to knockdown of MMP-9 gene with siRNA in EGF-treated VSMCs was significantly greater in the symptomatic group than the asymptomatic group. Thus, a selective blockade of both EGFR and MMP-9 may be a novel strategy and a promising target for stabilizing vulnerable plaques in patients with carotid stenosis.

  20. TGF superfamily and MMP2, MMP9, TIMP1 genes expression in the endometrium of women with impaired reproduction.

    Directory of Open Access Journals (Sweden)

    Przemysław Wirstlein

    2008-04-01

    Full Text Available During the putative "implantation window", a period of maximal endometrial receptivity that spans 7-9 days after ovulation, a series of changes on the structural and molecular level occur that render the endometrium susceptible to implantation for the human embryo. Many members of the TGFbetas are expressed by human endometrium at different stages of menstrual cycle. Also studies regarding the MMP2 gene expression and activity of MMP2 in the implantation window have shown a higher expression and activity of MMP2 in women with impaired fertility. We have examined by RT-PCR the expression of TGFbeta2 and MMP2, MMP9 and TIMP1 in 28 patients with idiopathic infertility, 16 patients with unexplained recurrent miscarriage and 16 control women were enrolled in this study. Seven to nine days after ovulation endometrial biopsy by Pipelle or hysteroscopy was performed to assess the expression of TGFbeta2 , MMP2, MMP9 and TIMP1. We found that in endometria from women with idiopathic infertility TGFbeta2 expression was 2.8 fold higher than in endometria from control group and 2.1 fold higher in endometrial samples from women with unexplained recurrent miscarriage compared to the control group. The MMP2, MMP9 and TIMP1 expression in endometrial samples revealed no significant differences between the study groups and control group. There was a statistically significant negative correlation between TGFbeta2 and MMP9 expression in endometria from women in control group. The present investigations suggest that dysregulated TGFbeta2, MMP2, MMP9 and TIMP1 expression are associated with infertility and early pregnancy loss. However the exact mechanism of how overexpression of endometrial TGFbetaand MMPs interferes with implantation may be more complex.

  1. Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth.

    Science.gov (United States)

    Burlaka, Anatoly P; Ganusevich, Irina I; Gafurov, Marat R; Lukin, Sergey M; Sidorik, Evgeny P

    2016-04-01

    High levels of reactive oxygen (ROS) and nitrogen (RNS) species can lead to the destruction of extracellular matrix facilitating tumor progression. ROS can activate matrix metalloproteinases (MMP), damage DNA and RNA. Therefore, the levels of MMP, ROS and RNS can serve as additional prognostic markers and for the estimation of the effectiveness of tumor therapy. Concerning gastric cancer, the prognostic role of MMP, its connection with the cancer staging remains controversial and correlations between the activity of MMP with the ROS and RNS levels are insufficiently confirmed. Superoxide generation rates, nitric oxide (NO) levels, concentrations of active forms of matrix metalloproteinases MMP-2 and MMP-9 in tumor and adjacent tissues of patients with stomach cancer at different disease stages were measured by electron spin resonance (ESR) including spin-trapping and polyacrylamide gel zymography. It is shown that the activity of MMP-2 and MMP-9 in tumor tissue correlate with the superoxide radicals generation rate and NO levels (r = 0.48÷0.67, p < 0.05). The activity of MMP-2 and MMP-9 in tumor tissues and superoxide radical generation rates correlate positively with the stage of regional dissemination (r = 0.45 and 0.37, correspondingly, p < 0.05), but MMP-2 and MMP-9 activity inversely depends on distant metastatic degree of stomach cancer (r = 0.58; p < 0.05). Additionally, the feasibility of ESR to locally determine oxidative stress is demonstrated.

  2. Correlation investigation between levels of MMP-2,MMP-3,MMP-10,TIMP-1 and type 1 diabetes with albuminuria%MMP -2、MMP -3、MMP -10及 TIMP -1与1型糖尿病蛋白尿的相关性研究

    Institute of Scientific and Technical Information of China (English)

    朱于坚

    2016-01-01

    Objective To investigate the correlation between levels of MMP - 2,MMP - 3,MMP - 10,TIMP - 1 and type 1 diabetes with albuminuria. Methods Fourty patients of type 1 diabetes with microalbuminuria or macroalbuminuria were selected in this study(observa-tion group). Meanwhile 40 healthy people for healthy check in the same period were selected as control group. General information and biochemi-cal indices(HbA1c,LDL,TC,MMP - 2,MMP - 3,MMP - 10,TIMP - 1,sVCAM - 1,E - selectin,CRP,IL - 6,TNF - α levels)in two group were compared. Simultaneously,MMP - 2,MMP - 3,MMP - 10,TIMP - 1,sVCAM - 1,E - selectin,CRP,IL - 6,TNF - α levels in patients with microalbuminuria and macroalbuminuria were compared. Respectively analysis MMPs and TIMP - 1 and sVCAM - 1 correlation of E- selectin,CRP,IL - 6,TNF - α. Results ①The levels of HbA1c,LDL,TC,MMP - 2,MMP - 3,MMP - 10,TIMP - 1,sVCAM - 1,E- selectin,CRP,IL - 6,TNF - αlevels in observation group were higher than those in control group,showing statistically significant difference( P 0. 05). ③MMP - 10,TIMP - 1 showed a significant positive correlation with sVCAM - 1and E - selectin( P < 0. 05). And MMP - 2 and MMP - 3 was negatively correlated with E - se-lectin and positively correlated with sVCAM - 1. MMP - 3,MMP - 10,TIMP - 1 displayed significantly positive correlation with CRP,TNF - α, IL - 6( P < 0. 05),but MMP - 2 only showed a significant positive correlation with IL - 6,and no significant correlation with CRP and TNF -α. Conclusion MMP - 2,MMP - 3,MMP - 10 and TIMP - 1 were related with albuminuria in type 1 diabetes - related. With the increased levels of albumin excretion,MMP - 2,MMP - 3,MMP - 10 and TIMP - 1 levels were accordingly increased,suggesting their correlation with the severity of albuminuria in type 1 diabetes.%目的探讨基质金属蛋白酶(MMP)-2、MMP -3、MMP -10及基质金属蛋白酶组织抑制因子(TIMP)-1与1型糖尿病蛋白尿的相关性。方法选择40例1型糖尿病伴微量

  3. MMP-2、MMP-9在乳腺导管癌中表达及意义%Expression and significance of MMP-2, MMP-9 in breast carcinoma

    Institute of Scientific and Technical Information of China (English)

    苏书娟; 邢鲁奇; 陈登庭; 邓淼

    2011-01-01

    Objective To research the expression and relationship of matrix metalloproteinase-2 ( MMP-2), metrix metalloproteinase-9(MMP-9) and collagen Ⅳ in breast ductal carcinoma. Methods Immunohistochemistry double staining was used to detect the expression of MMP-2, MMP-9 and collagen Ⅳ in 60 cases of breast ductal carcinoma and analyze their correlation. The relations between MMP-2, MMP-9 and breast ductal carcinoma tumor size, lymph node metastasis, and C-erbB-2 were analyzed. Results The positive expression rate of MMP-2 ,MMP-9 in breast ductal carcinoma was 75% and 80% ,respectively,which were significantly higher than the rate of 10% in normal breast tissues. MMP-2 and MMP-9 were expressed more strongly in the cancer cells approaching the basement membrane or breaking through the basement membrane. The positive expressions of MMP-2 and MMp-9 in the tumor diameter > 2em, with lymph node metastasis, and C-erbB-2 positive group were 83.9% and 90. 3% ,87.0% and 91.3% ,and 80. 9% and 85. 1% ,which were significantly higher than 58.6% and 65.5% ,64. 9% and 67. 6% ,and 46. 2% and 53. 8% of the correponding control groups. Collagen Ⅳ expression and the expression of MMP-2, MMP-9 was negatively correlated. Conclusion The degradation of collagen Ⅳ related to MMP-2 and MMP-9 may play an important role in local invasive and distant metastasis of breast ductal carcinoma. The expressions of MMP-2 ,MMP-9 and collagen Ⅳ may have reference value in determining the invasive and metastatic potential of breast carcinoma and evaluating prognosis.%目的 研究乳腺导管癌中基质金属蛋白酶-2(MMP-2)和基质金属蛋白酶-9(MMP-9)的表达及与Ⅳ型胶原(collagenⅣ)的关系.方法 免疫组化双染法检测60例乳腺导管癌中MMP-2、MMP-9和Ⅳ型胶原的表达并分析其相关性及与肿瘤大小、淋巴结转移及人类表皮生长因子受体-2(C-erbB-2)的关系.结果 MMP-2、MMP-9在乳腺导管癌中

  4. A multi-disciplinary approach for sea water quality monitoring: the IOSMOS project

    Science.gov (United States)

    Lacava, Teodosio; Ciancia, Emanuele; Coviello, Irina; Daraio, Maria; Paciello, Rossana; Pergola, Nicola; Pignatti, Stefano; Santini, Federico; Tramutoli, Valerio; Vallianatos, Filippos

    2013-04-01

    Coastal zones are complex and dynamic ecosystems which represent one of the most productive areas of the marine environment. They are an important economic resource for human populations: they provide food, energy as well as a lot of commerce and recreation activities. The strong anthropization, the irrational exploitation of resources and the climate changes are causing a strong modification of the coastal areas, representing a continuous threat to the biodiversity of these areas. This is why coastal zones deserve the developing and implementing of a monitoring system able to guarantee their consistent and reliable control as well as to timely identify any sign of degradation. Water quality is an important indicator of the health of coastal ecosystem. Remote sensing data can give relevant information in this framework, offering the capability to provide the spatial distribution of water constituents over large spatial areas with high temporal rates and relatively low costs. In particular Ocean Color (OC) satellite instruments furnish information both on sea surface optical variables (e.g. upwelling normalized water-leaving radiances) and on bio-optical parameters such as chlorophyll-a (as a proxy of phytoplankton), suspended materials and dissolved organic matter. A study of these parameters and of their evolution in the space-time domain may provide useful information on the overall quality of the sea water for a specific area, offering, in addition the reference behaviors necessary for identifying significant changes (possibly induced by anthropogenic pressure) in the coastal environment. In this context main aim of IOSMOS (IOnian Sea water quality MOnitoring by Satellite data) - a Project for European Transnational Cooperation co financed by the Operational Programme ERDF Basilicata 2007-2013 - is the development of advanced and exportable satellite products for measuring the above mentioned coastal water parameters as well as to timely identify short

  5. Field experience with a novel pipe protection and monitoring system for large offshore pipeline construction projects

    Energy Technology Data Exchange (ETDEWEB)

    Magerstaedt, Michael; Blitz, Gunther [ROSEN Swiss AG, Stans (Switzerland); Sabido, Carlos E. [ROSEN Technology and Research Center, Lingen (Germany)

    2012-07-01

    For pipe joints stored during large-scale offshore pipeline construction projects, corrosion protection as well as protection from physical damage of pipelines is very important. Integrity Management does not just start with the operation of a pipeline. In the past, with the much lower risks and cost at stake in on shore constriction, this factor was often overlooked. Sometimes, newly laid pipelines failed upon hydrostatic testing or even during operation. Causes were corrosion or damage the pipe joints took before pipeline laying. For offshore projects, the cost and consequences associated with such failures are orders of magnitude higher and must be avoided by all means. Within six months from the conception of the idea, a system was developed and deployed that protected (and in part still protects) a large number of pipe joints used in a European offshore gas pipeline project more than 2000 km. The pipe joints were physically protected from corrosion, interior contamination, and condensation. At the same time, the system provided real-time monitoring of more than 100'000 pipe joints stored at 5 storage yards distributed over 3 countries with distances of more than 1200 km apart from each other. Every single joint was identified with its location and status at every time during the storage period. Any third-party interference was transmitted to a central control room in real time as well. Protection of the pipe joints was provided vs.: corrosion of pipe joint end cutbacks exposed to the maritime climate for up to 2 years; contamination of the pipe interior by: foreign material, dirt, water, ice, animals. Third party damage to the pipe joints; damage to the protection system or to the transmission network; fire; theft of pipe joints or other equipment. System features were: modular pipe caps that, protect the pipe interior, cover both inner and outer cutback, allow ventilation of the pipe interior, continuously monitor each pipe joint for third party damage

  6. A greenhouse gas monitoring and modelling system for Switzerland: The CarboCount CH project

    Science.gov (United States)

    Brunner, Dominik; Buchmann, Nina; Eugster, Werner; Seneviratne, Sonia; Davin, Edouard; Gruber, Nicolas; Leuenberger, Markus; Bey, Isabelle; Bamberger, Ines; Henne, Stephan; Liu, Yu; Mystakidis, Stefanos; Oney, Brian; Roches, Anne

    2014-05-01

    emission inventories. Atmosphere-biosphere exchange fluxes of CO2 are simulated with the coupled system COSMO-CLM2, i.e. COSMO coupled to the Community Land Model, a state-of-the-art land processes and biogeochemistry model. Here we present a general outline of the project, the setup of the measurement network and of the different modeling components and inverse methods. We have performed transport simulations for the first year of observations and calculated the contributions from anthropogenic and biogenic sources/sinks upstream of the measurement sites. The generally good agreement between simulated and measured concentrations underlines the high quality of the transport simulations, but occasional deviations are pointing towards weaknesses in both the emission inventories and in the simulated meteorology. The CarboCount CH project provides an ideal test bed for future carbon monitoring systems, to test the suitability of different types of monitoring stations, to analyze the challenges of a heterogeneous landscape, and to identify critical modelling components.

  7. Community Air Sensor Network (CAIRSENSE) Project: Lower Cost, Continuous Ambient Monitoring Methods

    Science.gov (United States)

    CAIRSENSE Project presentation was given at the 108th Annual Meeting of the Air & Waste Management Associate in June 2015. The presentation provides an overview of the CAIRSENSE Project and general info about the sensors used in the CAIRSENSE Project.

  8. ["When the ad is good, the product is sold." The MonitorACAO Project and drug advertising in Brazil].

    Science.gov (United States)

    Soares, Jussara Calmon Reis de Souza

    2008-04-01

    This paper presents an analysis on drug advertising in Brazil, based on the final report of the MonitorACAO Project, by the group from the Universidade Federal Fluminense, Niterói, Rio de Janeiro. Due to a partnership between the university and the National Agency for Health Surveillance (ANVISA), drug advertisements were monitored and analyzed for one year, according to the methodology defined by the Agency. The samples were collected in medical practices and hospitals, drugstores, pharmacies and in scientific magazines. TV and radio programs were monitored, in the case of OTC drugs. 159 advertisements referring to pharmaceuticals were sent to ANVISA,from a total of 263 irregular ads analyzed between October 2004 and August 2005. The main problems found were the poor quality of drug information to health professionals, as well as misleading drug use to lay population. Based on the results of this project and on other studies, the banning of drug advertising in Brazil is proposed.

  9. Big Data solution for CTBT monitoring: CEA-IDC joint global cross correlation project

    Science.gov (United States)

    Bobrov, Dmitry; Bell, Randy; Brachet, Nicolas; Gaillard, Pierre; Kitov, Ivan; Rozhkov, Mikhail

    2014-05-01

    Waveform cross-correlation when applied to historical datasets of seismic records provides dramatic improvements in detection, location, and magnitude estimation of natural and manmade seismic events. With correlation techniques, the amplitude threshold of signal detection can be reduced globally by a factor of 2 to 3 relative to currently standard beamforming and STA/LTA detector. The gain in sensitivity corresponds to a body wave magnitude reduction by 0.3 to 0.4 units and doubles the number of events meeting high quality requirements (e.g. detected by three and more seismic stations of the International Monitoring System (IMS). This gain is crucial for seismic monitoring under the Comprehensive Nuclear-Test-Ban Treaty. The International Data Centre (IDC) dataset includes more than 450,000 seismic events, tens of millions of raw detections and continuous seismic data from the primary IMS stations since 2000. This high-quality dataset is a natural candidate for an extensive cross correlation study and the basis of further enhancements in monitoring capabilities. Without this historical dataset recorded by the permanent IMS Seismic Network any improvements would not be feasible. However, due to the mismatch between the volume of data and the performance of the standard Information Technology infrastructure, it becomes impossible to process all the data within tolerable elapsed time. To tackle this problem known as "BigData", the CEA/DASE is part of the French project "DataScale". One objective is to reanalyze 10 years of waveform data from the IMS network with the cross-correlation technique thanks to a dedicated High Performance Computer (HPC) infrastructure operated by the Centre de Calcul Recherche et Technologie (CCRT) at the CEA of Bruyères-le-Châtel. Within 2 years we are planning to enhance detection and phase association algorithms (also using machine learning and automatic classification) and process about 30 terabytes of data provided by the IDC to

  10. Getting Results in Housing: A Framework for Monitoring Results in Housing Projects: Using Measurable Indicators

    OpenAIRE

    Shlomo Angel; Michael Jacobs

    2006-01-01

    The aim of this paper is to help project teams develop results indicators for housing projects. These indicators are intended, primarily, as an instrument for managing projects and should help staff in the country offices, in headquarters and in executing agencies to identify the components of a project that are working as intended, and the ones that may need attention to keep the project on track. Additionally, the indicators can provide a foundation for project evaluations, at the mid-term ...

  11. Spatio-temporal expression of MMP-2, MMP-9 and tissue kallikrein in uteroplacental units of the pregnant guinea-pig (Cavia porcellus

    Directory of Open Access Journals (Sweden)

    Rey Sergio

    2007-07-01

    Full Text Available Abstract Background In humans trophoblast invasion and vascular remodeling are critical to determine the fate of pregnancy. Since guinea-pigs share with women an extensive migration of the trophoblasts through the decidua and uterine arteries, and a haemomonochorial placenta, this species was used to evaluate the spatio-temporal expression of three enzymes that have been associated to trophoblast invasion, MMP-2, MMP-9 and tissue kallikrein (K1. Methods Uteroplacental units were collected from early to term pregnancy. MMP-2, MMP-9 and K1 were analysed by immunohistochemistry and Western blot. The activities of MMP-2 and MMP-9 were assessed by gelatin zymography. Results Immunoreactive MMP-2, MMP-9 and K1 were detected in the subplacenta, interlobar and labyrinthine placenta, syncytial sprouts and syncytial streamers throughout pregnancy. In late pregnancy, perivascular or intramural trophoblasts expressed the three enzymes. The intensity of the signal in syncytial streamers was increased in mid and late pregnancy for MMP-2, decreased in late pregnancy for MMP-9, and remained stable for K1. Western blots of placental homogenates at days 20, 40 and 60 of pregnancy identified bands with the molecular weights of MMP-2, MMP-9 and K1. MMP-2 expression remained constant throughout gestation. In contrast, MMP-9 and K1 attained their highest expression during midgestation. Placental homogenates of 20, 40 and 60 days yielded bands of gelatinase activity that were compatible with MMP-2 and MMP-9 activities. ProMMP-2 and MMP-9 activities did not vary along pregnancy, while MMP-2 and MMP-9 increased at 40 and 40–60 days respectively. Conclusion The spatio-temporal expression of MMPs and K1 supports a relevant role of these proteins in trophoblast invasion, vascular remodeling and placental angiogenesis, and suggests a functional association between K1 and MMP-9 activation.

  12. KM and WEB 2.0 methods for project-based learning. MESHAT : a monitoring and experience sharing tool

    CERN Document Server

    Michel, Christine

    2011-01-01

    Our work aims at studying tools offered to learners and tutors involved in face-to-face or blended project-based learning activities. To understand better the needs and expectations of each actor, we are especially interested in the specific case of project management training. The results of a course observation show that the lack of monitoring and expertise transfer tools involves important dysfunctions in the course organisation and therefore dissatisfaction for tutors and students (in particular about the acquisition of knowledge and expertise). So as to solve this problem, we propose a personalised platform (according to the actor: project group, student or tutor), which gives information to monitor activities and supports the acquisition and transfer of expertise. This platform is based on Knowledge Management (KM) and Web 2.0 concepts to support the dynamic building of knowledge. KM is used to define the learning process (based on the experiential learning theory) and the way the individual knowledge b...

  13. The effect of a single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter on force-induced MMP-1 expression in human periodontal ligament cells

    NARCIS (Netherlands)

    Huang, Sheng-Fu; Li, Yu-Hong; Ren, Yi-Jin; Cao, Zheng-Guo; Long, Xing

    2008-01-01

    Matrix metalloproteinase-1 (MMP-1) 1G/2G (-1,607) polymorphisms have been identified and shown to influence the transcription of the MMP-1 gene. In order to compare the expression of MMP-1 with different MMP-1 gene promoter alleles after force loading, human periodontal ligament (PDL) cells were cul

  14. pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma

    DEFF Research Database (Denmark)

    Struckmann, K; Mertz, Kd; Steu, S;

    2008-01-01

    Loss of pVHL function, characteristic for clear-cell renal cell carcinoma (ccRCC), causes increased expression of CXCR4 chemokine receptor, which triggers expression of metastasis-associated MMP2/MMP9 in different human cancers. The impact of pVHL on MMP2/MMP9 expression and their relationship...

  15. CD147、MMP-1、MMP-2、MMP-9、TIMP-1、TIMP-2在不同级别的脑胶质瘤中的表达及其意义%Expressions of CD147, MMP-1, MMP-2,MMP-9,TIMP-1, TIMP-2 in different grades gliomas patients

    Institute of Scientific and Technical Information of China (English)

    居红格; 蒋剑英; 沈淑萍; 耿虹

    2010-01-01

    目的 探讨CD147、MMP-1、MMP-2、MMP-9、TIMP-1、TIMP-2在胶质瘤中的表达及其相关性,方法采用免疫组织化学法对78例石蜡包埋的胶质瘤组织和12例正常脑组织进行标记和分析.结果 CD147、MMP-1、MMP-2、MMP-9、TIMP-1、TIMP-2的阳性率分别为62%、66%、64%、75%、59%、59%,采用Spearman进行相关性分析,他们与胶质瘤的恶性程度均呈正相关(rs=0.2671~0.5631,P<0.05),CD147与MMP-1、MMP-2和MMP-9呈正相关(rs=0.3481~0.4951,P<0.05).结论 CD147、MMPS、TIMPs可以作为临床判断胶质瘤预后的分子生物学标志.

  16. 尿液中MMP-2、MMP-9及MMP-9/NGAL复合物的表达在乳腺癌筛查中的意义%The Clinical Significance of Determining Expressions of Urinary MMP-2,MMP-9 and MMP-9/NGAL Complex for Screening Patients with Breast Cancer in High-risk Female Population

    Institute of Scientific and Technical Information of China (English)

    申哲洙; 顾晋; 赵威; 张志谦

    2008-01-01

    目的 检测女性尿液中MMP-2、MMP-9及MMP-9/NGAL复合物的表达,探讨其在乳腺癌高危发病妇女普查筛选中的意义.方法 采用明胶酶底物电泳法和Western blot方法,检测正常女性(n=60)、乳腺良性疾病患者(n=41)、乳腺癌患者(n=127)尿液中MMP-2、MMP-9及MMP-9/NGAL复合物的表达情况.结果 MMP-2、MMP-9、MMP-9/NGAL复合物的表达在正常女性尿液中分别为23.33%、15%和13.33%;在乳腺良性疾病患者尿液中分别为43.93%、39.02%和36.59%;在乳腺癌患者尿液中分别为64.56%、76.37%和70.08%.乳腺癌患者尿液中MMP-2、MMP-9和MMP-9/NGAL复合物的表达与正常女性间差异有统计学意义(P<0.001);与乳腺良性疾病患者比较差异也有统计学意义(P<0.01).乳腺癌患者尿液中MMP-2+MMP-9+MMP-9/NGAL复合物同时表达,与乳腺良性疾病患者比较差异亦有统计学意义(P<0.01).结论 1)乳腺癌、乳腺良性疾病和正常女性尿液中MMP-2、MMP-9、MMP-9/NGAL复合物均有表达.但正常女性很少表达MMP-2和MMP-9,极少表达MMP-9/NGAL复合物.2)乳腺癌患者尿液中MMP-2+MMP-9+MMP-9/NGAL复合物的同时表达,对乳腺癌的诊断具有重要意义.对乳腺癌高危发病妇女的普查筛选也具有指导意义.

  17. The Urban Environmental Monitoring/100 Cities Project: Legacy of the First Phase and Next Steps

    Science.gov (United States)

    Stefanov, William L.; Wentz, Elizabeth A.; Brazel, Anthony; Netzband, Maik; Moeller, Matthias

    2009-01-01

    The Urban Environmental Monitoring (UEM) project, now known as the 100 Cities Project, at Arizona State University (ASU) is a baseline effort to collect and analyze remotely sensed data for 100 urban centers worldwide. Our overarching goal is to use remote sensing technology to better understand the consequences of rapid urbanization through advanced biophysical measurements, classification methods, and modeling, which can then be used to inform public policy and planning. Urbanization represents one of the most significant alterations that humankind has made to the surface of the earth. In the early 20th century, there were less than 20 cities in the world with populations exceeding 1 million; today, there are more than 400. The consequences of urbanization include the transformation of land surfaces from undisturbed natural environments to land that supports different forms of human activity, including agriculture, residential, commercial, industrial, and infrastructure such as roads and other types of transportation. Each of these land transformations has impacted, to varying degrees, the local climatology, hydrology, geology, and biota that predate human settlement. It is essential that we document, to the best of our ability, the nature of land transformations and the consequences to the existing environment. The focus in the UEM project since its inception has been on rapid urbanization. Rapid urbanization is occurring in hundreds of cities worldwide as population increases and people migrate from rural communities to urban centers in search of employment and a better quality of life. The unintended consequences of rapid urbanization have the potential to cause serious harm to the environment, to human life, and to the resulting built environment because rapid development constrains and rushes decision making. Such rapid decision making can result in poor planning, ineffective policies, and decisions that harm the environment and the quality of human life

  18. Subsurface Characterization and Seismic Monitoring for the Southwest Partnerships Phase III Demonstration Project at Farnsworth Field, TX

    Science.gov (United States)

    Will, R. A.; Balch, R. S.

    2015-12-01

    The Southwest Partnership on Carbon Sequestration is performing seismic based characterization and monitoring activities at an active CO2 EOR project at Farnsworth Field, Texas. CO2 is anthropogenically sourced from a fertilizer and an ethanol plant. The field has 13 CO2 injectors and has sequestered 302,982 metric tonnes of CO2 since October 2013. The field site provides an excellent laboratory for testing a range of monitoring technologies in an operating CO2 flood since planned development is sequential and allows for multiple opportunities to record zero CO2 baseline data, mid-flood data, and fully flooded data. The project is comparing and contrasting several scales of seismic technologies in order to determine best practices for large scale commercial sequestration projects. Characterization efforts include an 85 km2 3D surface seismic survey, baseline and repeat 3D VSP surveys centered on injection wells, cross-well tomography baseline and repeat surveys between injector/producer pairs, and a borehole passive seismic array to monitor induced seismicity. All surveys have contributed to detailed geologic models which were then used for fluid flow and risk assessment simulations. 3D VSP and cross-well data with repeat surveys have allowed for direct comparisons of the reservoir prior to CO2 injection and at eight months into injection, with a goal of imaging the CO2 plume as it moves away from injection wells. Additional repeat surveys at regular intervals will continue to refine the plume. The goal of this work is to demonstrate seismic based technologies to monitor CO2 sequestration projects, and to contribute to best practices manuals for commercial scale CO2 sequestration projects. In this talk the seismic plan will be outlined, progress towards goals enumerated, and preliminary results from baseline and repeat seismic data will be discussed. Funding for this project is provided by the U.S. Department of Energy under Award No. DE-FC26-05NT42591.

  19. Elevation of MMP-3 and MMP-9 in CSF and Blood in Patients with Severe Traumatic Brain Injury

    Science.gov (United States)

    Grossetete, Mark; Phelps, Jeremy; Arko, Leopold; Yonas, Howard; Rosenberg, Gary A.

    2009-01-01

    OBJECTIVE Traumatic brain injury (TBI) causes elevation of matrix metalloproteinases (MMPs), which are associated with neuroinflammation, blood-brain barrier (BBB) disruption, hemorrhage and cell death. We hypothesized that patients with TBI have an increase in MMPs in the ventricular cerebrospinal fluid (CSF) and plasma. METHODS Patients with TBI and a ventricular catheter were entered into the study. Samples of CSF and plasma were collected at the time of catheter placement, and 24 and 72 hrs after admission. Seven TBI patients were entered into the study with six having complete data for analysis. Only patients that had a known time of insult that fell within a six hour window from initial insult to ventriculostomy were accepted into the study. Control CSF came from ventricular fluid in patients undergoing shunt placement for normal pressure hydrocephalus (NPH). Both MMP-2 and MMP-9 were measured with gelatin zymography and MMP-3 with Western immunoblotting. RESULTS We found a significant elevation in the levels of the latent form of MMP-9 (92-kDa) in the CSF obtained at the time of arrival (TOA) (p<0.05). Elevated levels of MMP-2 were detected in plasma at 72 hours, but not in the CSF. Using albumin from both CSF and blood, we calculated the MMP-9 index, which was significantly elevated in the CSF, indicating endogenous MMP production. Western immunoblots showed increased levels of MMP-3 in CSF at all times measured, while MMP-3 was not detected in the CSF of NPH. CONCLUSIONS We show that MMPs are elevated in CSF of TBI patients. Although the number of patients was small, the results were robust and clearly demonstrated elevations of MMP-3 and MMP-9 in ventricular CSF in TBI patients compared to controls. While these preliminary results will need to be replicated, we propose that MMPs may be important in BBB opening and hemorrhage secondary to brain injury in patients. PMID:19834375

  20. Expression of MMP-2, MT1-MMP, and TIMP-2 by cultured rabbit corneal fibroblasts under mechanical stretch.

    Science.gov (United States)

    Liu, Chengxing; Feng, Pengfei; Li, Xiaona; Song, Jie; Chen, Weiyi

    2014-08-01

    Refractive surgery not only leads to tissue injury but also evokes mechanical stress increase of the cornea. How the mechanical stress affects the corneal matrix remodeling, specifically, matrix metalloproteinases (MMPs) and their inhibitors (tissue inhibitors of metalloproteinases; TIMPs) is not well understood. In this study, cultured rabbit corneal fibroblasts in vitro were subjected to regimen of 5%, 10%, or 15% equibiaxial stretch at 0.1 Hz for 3 or 24 h. MMP-2 protein level was measured by gelatin zymography and Western blotting. MMP-2, membrane type 1 MMP (MT1-MMP), and TIMP-2 mRNA levels were quantified by real-time quantitative PCR. Extracellular regulated protein kinase (ERK) phosphorylation protein levels were assessed by Western blotting. Our results showed that a 15% stretch resulted in increases in MMP-2 protein, MMP-2 mRNA, and MT1-MMP mRNA levels, but a decrease in TIMP-2 mRNA level. However, a 5% stretch caused decreases in MMP-2 protein and mRNA level, but an increase in TIMP-2 mRNA level, and no change in MT1-MMP mRNA level. A 15% stretch also caused a significant increase in ERK1/2 phosphorylation. Inhibition of the mitogenactivated protein kinase (MEK) pathway with PD98059 attenuated stretch-induced increase in MMP-2 production and ERK activity. These results suggest that small-magnitude stretching may promote corneal matrix synthetic events, whereas large-magnitude stretching promotes corneal matrix degradation by changing the balance between MMPs and TIMPs in corneal fibroblasts. Large-magnitude stretch-induced increase in pro-MMP-2 production was in an ERK-dependent manner. © 2014 by the Society for Experimental Biology and Medicine.

  1. Fire fighters and rescuers monitoring through wearable sensors: The ProeTEX project.

    Science.gov (United States)

    Magenes, Giovanni; Curone, Davide; Caldani, Laura; Secco, Emanuele Lindo

    2010-01-01

    The final generation of ProeTEX prototypes has been delivered in April 2010: it is based on two sets of sensorized garments devoted to monitor the health status of emergency operators working in harsh environments. This new release of garments shows several improvements with respect to the previous ones, and it is characterized by a major specialization to the requirements imposed by the different categories of end-users (Fire-Fighters, Civil Protection rescuers) addressed by the project. Each ProeTEX prototype is provided with a communication infrastructure allowing the real-time remote transmission of data recorded by the wearable sensors, and the presentation of such data to possible managers supervising the activities of the first line responders. After the delivery of the prototypes, an intense validation of the garments is being carried out both in laboratories, specialized in physiological measures, and in simulated fire-fighting scenarios. In such a context, this paper presents the main features characterizing the final ProeTEX prototypes and preliminary results of their laboratory assessment.

  2. The Lick AGN Monitoring Project: Recalibrating Single-Epoch Virial Black Hole Mass Estimates

    CERN Document Server

    Park, Daeseong; Treu, Tommaso; Barth, Aaron J; Bentz, Misty C; Bennert, Vardha N; Canalizo, Gabriela; Filippenko, Alexei V; Gates, Elinor; Greene, Jenny E; Malkan, Matthew A; Walsh, Jonelle

    2011-01-01

    We investigate the calibration and uncertainties of black hole mass estimates based on the single-epoch (SE) method, using homogeneous and high-quality multi-epoch spectra obtained by the Lick Active Galactic Nucleus (AGN) Monitoring Project for 9 local Seyfert 1 galaxies with black hole masses < 10^8 M_sun. By decomposing the spectra into their AGN and stellar components, we study the variability of the single-epoch Hbeta line width (full width at half-maximum intensity, FWHM_Hbeta; or dispersion, sigma_Hbeta) and of the AGN continuum luminosity at 5100A (L_5100). From the distribution of the "virial products" (~ FWHM_Hbeta^2 L_5100^0.5 or sigma_Hbeta^2 L_5100^0.5) measured from SE spectra, we estimate the uncertainty due to the combined variability as ~ 0.05 dex (12%). This is subdominant with respect to the total uncertainty in SE mass estimates, which is dominated by uncertainties in the size-luminosity relation and virial coefficient, and is estimated to be ~ 0.46 dex (factor of ~ 3). By comparing the...

  3. FINAL TECHNICAL REPORT: Underwater Active Acoustic Monitoring Network For Marine And Hydrokinetic Energy Projects

    Energy Technology Data Exchange (ETDEWEB)

    Stein, Peter J. [Scientific Solutions, Inc, Nashua, NH (United States); Edson, Patrick L. [Scientific Solutions, Inc, Nashua, NH (United States)

    2013-12-20

    This project saw the completion of the design and development of a second generation, high frequency (90-120 kHz) Subsurface-Threat Detection Sonar Network (SDSN). The system was deployed, operated, and tested in Cobscook Bay, Maine near the site the Ocean Renewable Power Company TidGen™ power unit. This effort resulted in a very successful demonstration of the SDSN detection, tracking, localization, and classification capabilities in a high current, MHK environment as measured by results from the detection and tracking trials in Cobscook Bay. The new high frequency node, designed to operate outside the hearing range of a subset of marine mammals, was shown to detect and track objects of marine mammal-like target strength to ranges of approximately 500 meters. This performance range results in the SDSN system tracking objects for a significant duration - on the order of minutes - even in a tidal flow of 5-7 knots, potentially allowing time for MHK system or operator decision-making if marine mammals are present. Having demonstrated detection and tracking of synthetic targets with target strengths similar to some marine mammals, the primary hurdle to eventual automated monitoring is a dataset of actual marine mammal kinematic behavior and modifying the tracking algorithms and parameters which are currently tuned to human diver kinematics and classification.

  4. Suncatcher Monitoring Project. Final report, September 1, 1977-December 31, 1978

    Energy Technology Data Exchange (ETDEWEB)

    Maeda, B.T.; Grant, P.W.; Anson, R.D.

    1979-08-01

    The Suncatcher Monitoring Project has to date accumulated a wide variety of data on the Nittler/Maeda Suncatcher house in Davis, California, designed by Living Systems. Highlights of the data indicate 70% solar heating during 1978 despite unusually adverse winter weather conditons and a 40% increase of solar energy in winter through clerestory glazing as compared to ordinary south glazing. The data acquisition system (DAS) only worked intermittently during 1978, but hourly data was gathered during several intervals and daily data was virtually continuous. As a back-up to this hourly gathering of data hand read data was taken daily from September 1977 to the present. This manually collected data has allowed a reliable estimate of the Suncatcher house's performance. Summer data on Suncatcher window performance has been collected for comparison purposes, but budget constraints have delayed completion of computer modeling of the Suncatcher performance. Comparison of the overall Suncatcher's performance with the estimation models, SOLEST and LASL6, and simulation model, SOLSIM, appear accurate, although completion of the reflector enhancement algorithm remains desirable.

  5. Earth Observation in Support of Sustainable Urban Planning: Results of the Dragon-3 Monitor Project

    Science.gov (United States)

    Cartalis, C.; Polydoros, A.; Mavrakou, T.; Asimakopoulos, D. N.

    2016-08-01

    Sustainable urban planning increasingly demands innovative concepts and techniques to obtain up-to-date and area-wide information on the characteristics and development of the urban system. In this paper, a thorough and conclusive presentation is made in terms of the results of the DRAGON-3 MONITOR project as based on the use of Earth Observation. Results refer in particular to a set of EO based dynamic urban indicators (i.e. urban form and expansion, land use/land cover changes, land surface temperature distribution, the presence and strength of urban heat island) with the capacity to describe the state, dynamic changes and interaction of the land and thermal environment in urban areas. Furthermore results are assessed in terms of their potential to operationally support sustainable urban planning and bridge the gap between EO scientists and urban planners. Constraints related to the spatial resolution and revisit time of satellite sensors are discussed as they influence the accuracy and applicability of the indicators. Methodologies to improve the applicability of the indicators are also discussed along with the presentation of the respective results.

  6. The Monitor project: the search for transits in the open cluster NGC 2362

    Science.gov (United States)

    Miller, Adam A.; Irwin, Jonathan; Aigrain, Suzanne; Hodgkin, Simon; Hebb, Leslie

    2008-06-01

    We present the results of a systematic search for transiting planets in a ~5 Myr open cluster, NGC 2362. We observed ~1200 candidate cluster members, of which ~475 are believed to be genuine cluster members, for a total of ~100 h. We identify 15 light curves with reductions in flux that pass all our detection criteria, and six of the candidates have occultation depths compatible with a planetary companion. The variability in these six light curves would require very large planets to reproduce the observed transit depth. If we assume that none of our candidates are, in fact, planets then we can place upper limits on the fraction of stars with hot Jupiters (HJs) in NGC 2362. We obtain 99 per cent confidence upper limits of 0.22 and 0.70 on the fraction of stars with HJs (fp) for 1-3 and 3-10 d orbits, respectively, assuming all HJs have a planetary radius of 1.5RJup. These upper limits represent observational constraints on the number of stars with HJs at an age <~10 Myr, when the vast majority of stars are thought to have lost their protoplanetary discs. Finally, we extend our results to the entire Monitor project, a survey searching young, open clusters for planetary transits, and find that the survey as currently designed should be capable of placing upper limits on fp near the observed values of fp in the solar neighbourhood.

  7. The Lick AGN Monitoring Project 2011: Reverberation Mapping of Markarian 50

    CERN Document Server

    Barth, A J; Thorman, S J; Bennert, V N; Sand, D J; Li, W; Canalizo, G; Filippenko, A V; Gates, E L; Greene, J E; Malkan, M A; Stern, D; Treu, T; Woo, J -H; Assef, R J; Bae, H -J; Brewer, B J; Buehler, T; Cenko, S B; Clubb, K I; Cooper, M C; Diamond-Stanic, A M; Hiner, K D; Hoenig, S F; Joner, M D; Kandrashoff, M T; Laney, C D; Lazarova, M S; Nierenberg, A M; Park, D; Silverman, J M; Son, D; Sonnenfeld, A; Tollerud, E J; Walsh, J L; Walters, R; da Silva, R L; Fumagalli, M; Gregg, M D; Harris, C E; Hsiao, E Y; Lee, J; Lopez, L; Rex, J; Suzuki, N; Trump, J R; Tytler, D; Worseck, G; Yesuf, H M

    2011-01-01

    The Lick AGN Monitoring Project 2011 observing campaign was carried out over the course of 11 weeks in Spring 2011. Here we present the first results from this program, a measurement of the broad-line reverberation lag in the Seyfert 1 galaxy Mrk 50. Combining our data with supplemental observations obtained prior to the start of the main observing campaign, our dataset covers a total duration of 4.5 months. During this time, Mrk 50 was highly variable, exhibiting a maximum variability amplitude of a factor of 4 in the U-band continuum and a factor of 2 in the H-beta line. Using standard cross-correlation techniques, we find that H-beta and H-gamma lag the V-band continuum by tau_cen = 10.64(-0.93,+0.82) and 8.43(-1.28,+1.30) days, respectively, while the lag of He II 4686 is unresolved. The H-beta line exhibits a symmetric velocity-resolved reverberation signature with shorter lags in the high-velocity wings than in the line core, consistent with an origin in a broad-line region dominated by orbital motion r...

  8. Modeling reverberation mapping data II: dynamical modeling of the Lick AGN Monitoring Project 2008 dataset

    CERN Document Server

    Pancoast, Anna; Treu, Tommaso; Park, Daeseong; Barth, Aaron J; Bentz, Misty C; Woo, Jong-Hak

    2013-01-01

    We present dynamical modeling of the broad line region (BLR) for a sample of five Seyfert 1 galaxies using reverberation mapping data taken by the Lick AGN Monitoring Project (LAMP) in 2008. The sample includes Arp 151, Mrk 1310, NGC 5548, NGC 6814, and SBS 1116+583A. By modeling the continuum light curve and H$\\beta$ line profiles directly we are able to constrain the geometry and kinematics of the BLR. Modeling the kinematics also allows us to make a measurement of the black hole mass that does not depend upon the virial coefficient or normalizing factor needed in traditional reverberation mapping analysis. We find that the geometry of the BLR is generally a thick disk viewed close to face-on, but a more spherical geometry is not ruled out for two of the five AGNs. While the H$\\beta$ is found to come preferentially from the far side of the BLR, the mean size of the BLR is consistent with the lags measured with cross-correlation analysis. The BLR kinematics are generally found to be consistent with either in...

  9. Modelling reverberation mapping data - II. Dynamical modelling of the Lick AGN Monitoring Project 2008 data set

    Science.gov (United States)

    Pancoast, Anna; Brewer, Brendon J.; Treu, Tommaso; Park, Daeseong; Barth, Aaron J.; Bentz, Misty C.; Woo, Jong-Hak

    2014-12-01

    We present dynamical modelling of the broad-line region (BLR) for a sample of five Seyfert 1 galaxies using reverberation mapping data taken by the Lick AGN Monitoring Project in 2008. By modelling the AGN continuum light curve and Hβ line profiles directly, we are able to constrain the geometry and kinematics of the BLR and make a measurement of the black hole mass that does not depend upon the virial factor, f, needed in traditional reverberation mapping analysis. We find that the geometry of the BLR is generally a thick disc viewed close to face-on. While the Hβ emission is found to come preferentially from the far side of the BLR, the mean size of the BLR is consistent with the lags measured with cross-correlation analysis. The BLR kinematics are found to be consistent with either inflowing motions or elliptical orbits, often with some combination of the two. We measure black hole masses of log _{10}(M_ BH/M_{odot })=6.62^{+0.10}_{-0.13} for Arp 151, 7.42^{+0.26}_{-0.27} for Mrk 1310, 7.59^{+0.24}_{-0.21} for NGC 5548, 6.37^{+0.21}_{-0.16} for NGC 6814, and 6.99^{+0.32}_{-0.25} for SBS 1116+583A. The f factors measured individually for each AGN are found to correlate with inclination angle, although not with M BH, L5100, or FWHM/σ of the emission line profile.

  10. TANK 241-AN-102 MULTI-PROBE CORROSION MONITORING SYSTEM PROJECT LESSONS LEARNED

    Energy Technology Data Exchange (ETDEWEB)

    TAYLOR T; HAGENSEN A; KIRCH NW

    2008-07-07

    During 2007 and 2008, a new Multi-Probe Corrosion Monitoring System (MPCMS) was designed and fabricated for use in double-shell tank 241-AN-102. The system was successfully installed in the tank on May 1, 2008. The 241-AN-102 MPCMS consists of one 'fixed' in-tank probe containing primary and secondary reference electrodes, tank material electrodes, Electrical Resistance (ER) sensors, and stressed and unstressed corrosion coupons. In addition to the fixed probe, the 241-AN-102 MPCMS also contains four standalone coupon racks, or 'removable' probes. Each rack contains stressed and unstressed coupons made of American Society of Testing and Materials A537 CL1 steel, heat-treated to closely match the chemical and mechanical characteristics of the 241-AN-102 tank wall. These coupon racks can be removed periodically to facilitate examination of the attached coupons for corrosion damage. Along the way to successful system deployment and operation, the system design, fabrication, and testing activities presented a number of challenges. This document discusses these challenges and lessons learned, which when applied to future efforts, should improve overall project efficiency.

  11. Yakima/Klickitat Fisheries Project Genetic Studies; Yakima/Klickitat Fisheries Project Monitoring and Evaluation, 2000-2001 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Busack, Craig A.; Schroder, Steven L.; Young, Sewall F. (Washington Department of Fish and Wildlife, Olympia, WA)

    2002-11-01

    Genetic work for 2001 consisted of two major phases, both reported on here. The first is a DNA microsatellite analysis of several hundred juveniles from the experimental spawning channel at the Cle Elum Supplementation Research Facility, using the genetic markers to assign the juveniles to parents, and thus judge reproductive success of individual fish. The second is a reevaluation and revision of plans for studying domestication in the spring chinook supplementation effort. The pedigree analysis was significant in three respects. First, it showed that this approach can be successfully applied to the spawning channel research. Secondly it showed that this approach does indeed yield very useful information about the relative reproductive success of fish in the channel. Finally, it showed that this information can yield additional information about the experimental design. Of the 961 juveniles on which analysis was attempted, 774 yielded enough genetic information to be used in the pedigree analysis. Of these, 754 were assigned to males and females known to have been placed into the channel. Of the other 20, all were assignable to females, but sires were unknown. The genotypes of 17 of these were consistent with a single theoretical male genotype, suggesting a single precocial male sired them. The inferred parentage of the fish demonstrated that there had been substantial leakage of juveniles from one section of the channel into another. Reproductive success of females was fairly even, but success of males varied considerably. In a group of seven males (including the hypothetical one), one contributed 79% of the progeny analyzed, and three contributed none. The domestication experimental design evaluation was prompted by a critical review of the project by the Independent Scientific Review Panel (ISRP). The ISRP review set into motion a design revision process which extended beyond the contract period; the report presented here is intended to be an account of our

  12. Geohazard monitoring and modelling using Persistent Scatterer Interferometry in the framework of the European project Terrafirma

    Science.gov (United States)

    Cooksley, Geraint; Arnaud, Alain; Banwell, Marie-Josée

    2013-04-01

    Increasingly, geohazard risk managers are looking to satellite observations as a promising option for supporting their risk management and mitigation strategies. The Terrafirma project, aimed at supporting civil protection agencies, local authorities in charge of risk assessment and mitigation is a pan-European ground motion information service funded by the European Space Agency's Global Monitoring for Environment and Security initiative. Over 100 services were delivered to organizations over the last ten years. Terrafirma promotes the use of Synthetic Aperture Radar Interferometry (InSAR) and Persistent Scatterer InSAR (PSI) within three thematic areas for terrain motion analysis: Tectonics, Flooding and Hydrogeology (ground water, landslides and inactive mines), as well as the innovative Wide Area mapping service, aimed at measuring land deformation over very large areas. Terrafirma's thematic services are based on advanced satellite interferometry products; however they exploit additional data sources, including non-EO, coupled with expert interpretation specific to each thematic line. Based on the combination of satellite-derived ground-motion information products with expert motion interpretation, a portfolio of services addressing geo-hazard land motion issues was made available to users. Although not a thematic in itself, the Wide Area mapping product constitutes the fourth quarter of the Terrafirma activities. The wide area processing chain is nearly fully automatic and requires only a little operator interaction. The service offers an operational PSI processing for wide-area mapping with mm accuracy of ground-deformation measurement at a scale of 1:250,000 (i.e. one cm in the map corresponds to 2.5 Km on the ground) on a country or continent level. The WAP was demonstrated using stripmap ERS data however it is foreseen to be a standard for the upcoming Sentinel-1 mission that will be operated in Terrain Observation by Progressive Scan (TOPS) mode. Within

  13. The Navruz Project: Transboundary Monitoring for Radionuclides and Metals in Central Asia Rivers. Sampling and Analysis Plan and Operational Manual

    Energy Technology Data Exchange (ETDEWEB)

    Passell, Howard D.; Barber, David S.; Betsill, J. David; Littlfield, Adriane C.; Mohagheghi, Amir H.; Shanks, Sonoya T.; Yuldashev, Bekhzad; Salikhbaev, Umar; Radyuk, Raisa; Djuraev, Akram; Djuraev, Amwar; Vasilev, Ivan; Tolongutov, Bajgabyl; Valentina, Alekhina; Solodukhin, Vladimir; Pozniak, Victor

    2002-04-02

    The transboundary nature of water resources demands a transboundary approach to their monitoring and management. However, transboundary water projects raise a challenging set of problems related to communication issues, and standardization of sampling, analysis and data management methods. This manual addresses those challenges and provides the information and guidance needed to perform the Navruz Project, a cooperative, transboundary, river monitoring project involving rivers and institutions in Kazakhstan, Kyrgyzstan, Tajikistan, and Uzbekistan facilitated by Sandia National Laboratories in the U.S. The Navruz Project focuses on waterborne radionuclides and metals because of their importance to public health and nuclear materials proliferation concerns in the region. This manual provides guidelines for participants on sample and data collection, field equipment operations and procedures, sample handling, laboratory analysis, and data management. Also included are descriptions of rivers, sampling sites and parameters on which data are collected. Data obtained in this project are shared among all participating countries and the public through an internet web site, and are available for use in further studies and in regional transboundary water resource management efforts. Overall, the project addresses three main goals: to help increase capabilities in Central Asian nations for sustainable water resources management; to provide a scientific basis for supporting nuclear transparency and non-proliferation in the region; and to help reduce the threat of conflict in Central Asia over water resources, proliferation concerns, or other factors.

  14. Matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) in preoperative serum as independent prognostic markers in patients with colorectal cancer.

    Science.gov (United States)

    Dragutinović, Vesna V; Radonjić, Nevena V; Petronijević, Nataša D; Tatić, Svetislav B; Dimitrijević, Ivan B; Radovanović, Nebojša S; Krivokapić, Zoran V

    2011-09-01

    Colorectal cancer is one of the leading causes of cancer related death in developed countries. One of the reasons is the absence of tumor specific diagnostic and prognostic markers. The aim of this study was to examine the correlation of matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) expressions in serum and clinicopathological features of the colorectal adenocarcinoma. Another aim was to examine expression of MMP-9 in the tissue of the colorectal carcinoma in MMP-9 serum positive patients. In addition, we tried to establish the correlation between preoperative levels of serum markers (CEA and CA 19-9) and presence of MMP-2 or MMP-9. The study was performed on 32 patients with colorectal adenocarcinoma who underwent surgery and 11 patients in a control group who were operated for benign diseases. The samples were analyzed by SDS-PAGE to determine the molecular mass and SDS-PAGE zymography to determine levels of MMP-2 and MMP-9. Expression of MMP-9 was determined immunohistochemically in the tissue of the colorectal carcinoma of MMP-9 serum positive patients. MMP-2 and MMP-9 levels were increased in the serum of the patients with colorectal cancer compared to the control group. There was significant correlation in MMPs levels among the patients with tumor stage I and II and the patients with tumor stage III and IV. Obtained results did not demonstrate correlation between levels of CEA, CA 19-9 and presence of MMP-2 or MMP-9. MMP-9 expression was positive in 85% of MMP-9 serum positive patients with colorectal carcinoma. The overexpression of MMP-2 and MMP-9 strongly suggests its association with colorectal adenocarcinoma. Detection of MMP-2 and MMP-9 in serum might be useful for identification of patients with higher risk for colorectal cancer recurrence.

  15. Matrix metalloproteinase (MMP)-2 and MMP-9 as inflammation markers of Trichinella spiralis and Trichinella pseudospiralis infections in mice.

    Science.gov (United States)

    Bruschi, F; Bianchi, C; Fornaro, M; Naccarato, G; Menicagli, M; Gomez-Morales, M A; Pozio, E; Pinto, B

    2014-10-01

    Trichinella spiralis and Trichinella pseudospiralis exhibit differences in the host-parasite relationship such as the inflammatory response in parasitized muscles. Several studies indicate that matrix metalloproteinases (MMPs) represent a marker of inflammation since they regulate inflammation and immunity. The aim of this study was to evaluate the serum levels of gelatinases (MMP-9 and MMP-2) in mice experimentally infected with T. spiralis or T. pseudospiralis, to elucidate the involvement of these molecules during the inflammatory response to these parasites. Gelatin zymography on SDS polyacrilamide gels was used to assess the serum levels and in situ zymography on muscle histological sections to show the gelatinase-positive cells. In T. spiralis infected mice, the total MMP-9 serum level increased 6 days post-infection whereas, the total MMP-2 serum level increased onward. A similar trend was observed in T. pseudospiralis infected mice but the MMP-9 level was lower than that detected in T. spiralis infected mice. Significant differences were also observed in MMP-2 levels between the two experimental groups. The number of gelatinase positive cells was higher in T. spiralis than in T. pseudospiralis infected muscles. We conclude that MMP-9 and MMP-2 are markers of the inflammatory response for both T. spiralis and T. pseudospiralis infections.

  16. MMP-9 and MMP-2 gelatinases and TIMP-1 and TIMP-2 inhibitors in breast cancer: correlations with prognostic factors.

    Science.gov (United States)

    Jinga, D C; Blidaru, A; Condrea, Ileana; Ardeleanu, Carmen; Dragomir, Cristina; Szegli, G; Stefanescu, Maria; Matache, Cristiana

    2006-01-01

    The goal of our study was to analyse the prognostic values for some matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in breast cancer. We evaluated the activity and the expression levels of MMP-9, MMP-2, TIMP-1 and TIMP-2 in malignant versus benign fresh breast tumor extracts. For this purpose, gelatinzymography, immunoblotting and ELISA were used to analyse the activity and expression of MMPs and TIMPs. We found that MMP-9 expression level and activity are increased in malignant tumors. In addition, MMP-9/TIMP-1 and MMP-2/TIMP-2 ratio values obtained by us were significantly different in malignant tumors compared to benign tumors. We suggest that the abnormal MMP-9/TIMP-1 balance plays a role in the configuration of breast invasive carcinoma of no special type and also in tumor growth, while altered MMP-2/TIMP-2 ratio value could be associated with lymph node invasion and used as a prognostic marker in correlation with Nottingham Prognostic Index. Finally, we showed that in malignant tumors high expression of estrogen receptors is associated with enhanced activity of MMP-2 and increased bcl- 2 levels, while high expression of progesterone receptors is correlated with low TIMP-1 protein levels.

  17. Emergency Management and Radiation Moni-toring in Nuclear and Radiological Accidents. Summary Report on the NKS Project EMARAD

    Energy Technology Data Exchange (ETDEWEB)

    Lahtinen, J. [Radiation and Nuclear Safety Authority (STUK) (Finland)

    2006-04-15

    In order to manage various nuclear or radiological emergencies the authorities must have pre-prepared plans. The purpose of the NKS project EMARAD (Emergency Management and Radiation Monitoring in Nuclear and Radiological Accidents) was to produce and gather various data and information that could be useful in drawing up emergency plans and radiation monitoring strategies. One of the specific objectives of the project was to establish a www site that would contain various radiation-threat and radiation-monitoring related data and documents and that could be accessed by all Nordic countries. Other important objectives were discussing various factors affecting measurements in an emergency, efficient use of communication technology and disseminating relevant information on such topics as urban dispersion and illicit use of radiation. The web server is hosted by the Radiation and Nuclear Safety Authority (STUK) of Finland. The data stored include pre-calculated consequence data for nuclear power plant accidents as well as documents and presentations describing e.g. general features of monitoring strategies, the testing of the British urban dispersion model UDM and the scenarios and aspects related to malicious use of radiation sources and radioactive material. As regards the last item mentioned, a special workshop dealing with the subject was arranged in Sweden in 2005 within the framework of the project. (au)

  18. Earth Observation in aid of surge monitoring and forecasting: ESA's eSurge Project

    Science.gov (United States)

    Harwood, Phillip; Cipollini, Paolo; Snaith, Helen; Høyer, Jacob; Dwyer, Ned; Dunne, Declan; Stoffelen, Ad; Donlon, Craig

    2013-04-01

    The understanding and realistic modelling of surges supports both preparation and mitigation activities and should eventually bring enormous societal benefits, especially to some of the world's poorest countries. Earth Observation data from satellites have an important role to play in storm surge monitoring and forecasting, but the full uptake of these data by the users (such as environmental agencies and tidal prediction centres) must be first encouraged by showcasing their usefulness, and then supported by providing easy access. The European Space Agency has recognized the above needs and, through its Data User Element (DUE) programme, has initiated in 2011 the eSurge project, whose aims are: a) to contribute through Earth Observation to an integrated approach to storm surge, wave, sea-level and flood forecasting as part of a wider optimal strategy for building an improved forecast and warning capability for coastal inundation; and b) to increase the use of the advanced capabilities of ESA and other satellite data for storm surge applications. The project is led by Logica UK, with NOC (UK), DMI (Denmark), CMRC (Ireland) and KNMI (Netherlands) as scientific partners. eSurge aims to provide easy access to a wide range of relevant data for a range of historical surge events, as well as performing a series of experiments to demonstrate the value of this data, and running workshops and training courses to help users make use of the available data. The eSurge database of Earth Observation and in situ measurements for past surge events is now publicly available. In 2013 the project moves into its service demonstration phase, adding more data and events, including a demonstration near real time service. The project works closely with its users in order to meet their needs and to maximise the return of this data. A novel dataset provided by eSurge is coastal altimetry. Coastal altimetry has a prominent role to play as it measures directly the total water level envelope

  19. 下肢曲张静脉壁MMP-2、MMP-9和胶原含量的临床研究%Clinical study of MMP-2, MMP-9 and collagen in lower limb varicose veins

    Institute of Scientific and Technical Information of China (English)

    邵拥军; 朱化刚; 周静

    2012-01-01

    目的研究曲张大隐静脉管壁基质金属蛋白酶(MMP)-2、MMP-9的表达及其与临床症状和体征分期的关系,并检测曲张静脉壁总的胶原含量,探讨MMP-2、MMP-9和胶原在曲张静脉重塑时的作用.方法采用免疫组化SP法检测曲张静脉壁和正常大隐静脉壁MMP-2和MMP-9的表达,采用Masson染色法检测曲张静脉壁和正常对照组总的胶原含量,采用χ2检验和t检验进行统计学分析处理.结果 MMP-2和MMP-9在正常静脉壁和曲张静脉壁均有表达,但曲张静脉壁MMP-2和MMP-9的阳性率明显升高(P<0.05);C4-C6期MMP-2和MMP-9的阳性率明显高于C1-C3期(P<0.05);曲张静脉壁总的胶原含量显著高于正常对照组(P<0.05).结论 MMP-2、MMP-9的异常表达导致了静脉壁总的胶原含量增加,参与了曲张静脉的重塑.%Objective To investigate the expression of matrix metalloproteinase -2 and -9 in varicose veins, and their relationships with clinical stages , and to discuss the changes of total collagen in varicose veins, and their significance. Methods The expression of MMP-2 and MMP-9 was examined by immunohistochemistry SP methods in varicose veins (VV) and normal veins (NVV), the total collagen was detected using Masson staining in varicose veins and normal veins, and chi-square test and T- test was used for statistical analysis. Results MMP-2 and -9 were both expressed in NVV and VV, and the positive expression rate in VV was significantly higher than that in NVV (P< 0.05). The positive expression of MMP-2 and -9 was significantly higher in C4-C6 stages than in C1-C3 stages (P <0.05), and the collagen was significantly increased in varicose veins (P <0.05). Conclusion The abnormal expression of MMP-2 and -9 leads to collagen increasing in varicose veins, which may participate in vascular remodeling in varicose veins.

  20. Aircraft Engine Life-Consumption Monitoring for Real-Time Reliability Determination Project

    Data.gov (United States)

    National Aeronautics and Space Administration — A real-time life-use consumption monitor is proposed for aircraft engine systems. The life monitor will process power data available on the aircraft to calculate the...

  1. Autonomus I&C Maintenance and Health Monitoring System for Fission Surface Power Project

    Data.gov (United States)

    National Aeronautics and Space Administration — There currently exists no end-to-end reactor/power conversion monitoring system that can provide both autonomous health monitoring, but also in-situ sensor...

  2. Final Restoration and Mitigation Monitoring Plan for the Island Ponds Restoration Project

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Restoration and Mitigation Monitoring Plan (RMMP) presents the approaches necessary to satisfy mitigation and monitoring requirements described in the various...

  3. Advanced Rapid Imaging & Analysis for Monitoring Hazards (ARIA-MH) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Develop a service-oriented hazard/disaster monitoring data system enabling both science and decision-support communities to monitor ground motion in areas of...

  4. The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination.

    Science.gov (United States)

    Marusak, Charles; Bayles, Ian; Ma, Jun; Gooyit, Major; Gao, Ming; Chang, Mayland; Bedogni, Barbara

    2016-11-01

    MT1-MMP and MMP2 have been implicated as pro-tumorigenic and pro-metastatic factors in a wide variety of cancers including melanoma. We have previously demonstrated that MT1-MMP is highly expressed in melanoma where it promotes melanoma cell invasion and metastasis in part through the activation of its target MMP2. Given the accessibility of MMPs, as they are either secreted (e.g. MMP2) or membrane-tethered (e.g. MT1-MMP), they represent ideal targets for specific inhibition via small molecules. Here we show that the novel small-molecule inhibitor ND-322 with high selectivity for MT1-MMP and MMP2, effectively inhibits MT1-MMP and MMP2 activity resulting in reduced in vitro melanoma cell growth, migration and invasion. Importantly, these inhibitory effects lead to significant reduction of melanoma tumor growth and metastasis. We further show that while cell migration and invasion could be similarly hampered by specific inhibition of either MT1-MMP or MMP2 via shRNAs, the growth inhibitory activity of ND-322 could only be mirrored by specific inhibition of MT1-MMP. These data support ND-322 as a novel effective inhibitor capable of counteracting both MT1-MMP and MMP2, two key proteases involved in melanoma growth and metastasis. ND-322 may therefore represent a new inhibitor in the repertoire of treatments against melanoma. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Role of immunohistochemical overexpression of matrix metalloproteinases MMP-2 and MMP-11 in the prognosis of death by ovarian cancer.

    Science.gov (United States)

    Périgny, Martine; Bairati, Isabelle; Harvey, Isabelle; Beauchemin, Michel; Harel, François; Plante, Marie; Têtu, Bernard

    2008-02-01

    Matrix metalloproteinases (MMPs) are enzymes thought to be involved in tumor invasion. We hypothesized that MMP-2 and MMP-11 overexpression was associated with the aggressiveness of ovarian carcinoma. This study was performed on samples from 100 patients with stage III ovarian carcinomas treated surgically between 1990 and 2000. Immunohistochemical staining was performed on ovarian tumors and peritoneal implants using monoclonal antibodies. Overexpression was defined as more than 10% of cells expressing the marker. Multivariate analyses showed that only MMP-2 overexpression by cancer cells in peritoneal implants was associated with a significant risk of death by disease (hazard ratio, 2.65; 95% confidence interval, 1.41-4.97; P =.003). MMP-11 overexpression was not predictive of survival. These results suggest that MMP-2 overexpression by cancer cells in peritoneal implants and not in the primary ovarian cancer is predictive of ovarian cancer prognosis and more likely reflects the presence of particularly aggressive clones of cancer cells.

  6. The Expression and Clinical Significance of C-erbB-2, MMP-1,MMP-2, MMP-7 and MTA1 in Esophageal Cancer of the Kazak%C-erbB-2、MMP-1、MMP-2、MMP-7和MTA1在哈萨克族食管癌中的表达及其临床意义

    Institute of Scientific and Technical Information of China (English)

    李秀梅; 王洪江; 陈艳; 庞作良; 李卉; 姜孝芳; 古丽努尔·木哈依; 谌宏鸣; 李惠武

    2011-01-01

    通过观察C-erbB-2、MMP-1、MMP-2、MMP-7和MTA1 5个基因在哈萨克族食管癌组织中的表达,探讨其侵袭转移相关因子在新疆哈萨克族食管癌组织的表达和临床意义.采用RT-PCR方法检测75例哈萨克族食管癌标本中这5个基因的mRNA表达水平,分析它们与临床病理特征的关系.结果显示,5个基因在哈萨克族食管癌组织中表达较正常组织增高,达到差异显著(P<0.05);MMp-2、MMP-7、MTA1基因的表达与淋巴结转移相关(P<0.05),MMP-1、MMP-7基因的表达与临床分期正相关(P<0.05):C-erbB-2与MTA1、MMP-2与MTA1、MMP-7与MTA1、MMP-7与MMP-1、MMP-1与MTA1基因的表达差异高度一致(P<0.01).由此得出,这5个基因表达上调在哈萨克族食管癌的发生发展过程中协同发挥作用;MMP-2、MMP-7、MTA1可能是哈萨克族食管癌发生侵袭、转移的主导因素.%The expressions of C-erbB-2, MMP-1.MMP-2, MMP-7 and MTA 1 in esophageal cancer tissue and normal tissue among the Kazak are studied and the relationshlp between their expressions and clinical pathological feature is investigated. The expression of C-erbB-2, MMP-1, MMP-2, MMP-7 and MTA 1 gene mRNA were detected by using RT-PCR method in 75 esopthageal cancer specimens of the Kazak. The results show that the positive rates of C-erbB-2, MMP-1, MMP-2, MMP-7 and MTA 1 in cancer tisssue are higher than that of normal tissues (p<0.05). While the expression mRNA level of MMP-2, MMP-7 and MTA 1 is significantly related to the lymphnode metasis,And the expression mRNA level of MMP-1 MMP-7 is sigaificantly related to the TNM stages (P<O.05). Kappa analysis indicates that the expressions between C-erbB-2 and MTA 1, MMP-2 and MTA 1, MMP-7 and MTA 1, MMP-7 and MMP-1,MMP-1 and MTA 1 in the Kazak's esophageal cancer are positively related (k=O.624, 0.367, 0.564, 0.275.0.384. P<0.0l) with each other The conclusion shows that the over expression of C-erbB-2, MMP-1, MMP-2, MMP-7 and MTA 1 gene could play the

  7. Soil Contamination, Advanced integrated characterisation and time-lapse Monitoring, SoilCAM project highlights

    Science.gov (United States)

    French, H. K.; Van Der Zee, S. E.; Wehrer, M.; Godio, A.; Pedersen, L. B.; Tsocano, G.

    2013-12-01

    The SoilCAM project (2008- 2012, EU-FP7-212663) aimed at improving methods for monitoring subsurace contaminant distribution and biodegradation. Two test sites were chosen, Oslo airport Gardermoen, Norway where de-icing agents infiltrate the soil during snowmelt and the Trecate site in Italy where an inland crude oil spill occurred in 1994. A number of geophysical investigation techniques were combined with soil and water sampling techniques. Data obtained from time-lapse measurements were further analysed by numerical modelling of flow and transport at different scales in order to characterise transport processes in the unsaturated and saturated zones. Laboratory experiments provided physical and biogeochemical data for model parameterisation and to select remediation methods. The geophysical techniques were used to map geological heterogeneities and to conduct time-lapse measurements of processes in the unsaturated zone. Both cross borehole and surface electrodes were used for electrical resistivity and induced polarisation surveys. Results showed clear indications of areas highly affected by de-icing chemicals along the runway at Oslo airport. The time lapse measurements along the runway at the airport showed infiltration patterns during snowmelt and were used to validate 2D unsaturated flow and transport simulations using SUTRA. The simulations illustrate the effect of layering geological structures and membranes, buried parallel to the runway, on the flow pattern. Complex interaction between bio-geo-chemical processes in a 1D vertical profile along the runway were described with the ORCHESTRA model. Smaller scale field site measurements revealed increase of iron and manganese during degradation of de-icing chemicals. At the Trecate site a combination of georadar, electrical resistivity and radio magneto telluric provided a broad outline of the geology down to 50 m. Anomalies in the Induced polarisation and electrical resistivity data from the cross borehole

  8. Decomposition of Near-Infrared Spectroscopy Signals Using Oblique Subspace Projections: Applications in Brain Hemodynamic Monitoring

    Science.gov (United States)

    Caicedo, Alexander; Varon, Carolina; Hunyadi, Borbala; Papademetriou, Maria; Tachtsidis, Ilias; Van Huffel, Sabine

    2016-01-01

    Clinical data is comprised by a large number of synchronously collected biomedical signals that are measured at different locations. Deciphering the interrelationships of these signals can yield important information about their dependence providing some useful clinical diagnostic data. For instance, by computing the coupling between Near-Infrared Spectroscopy signals (NIRS) and systemic variables the status of the hemodynamic regulation mechanisms can be assessed. In this paper we introduce an algorithm for the decomposition of NIRS signals into additive components. The algorithm, SIgnal DEcomposition base on Obliques Subspace Projections (SIDE-ObSP), assumes that the measured NIRS signal is a linear combination of the systemic measurements, following the linear regression model y = Ax + ϵ. SIDE-ObSP decomposes the output such that, each component in the decomposition represents the sole linear influence of one corresponding regressor variable. This decomposition scheme aims at providing a better understanding of the relation between NIRS and systemic variables, and to provide a framework for the clinical interpretation of regression algorithms, thereby, facilitating their introduction into clinical practice. SIDE-ObSP combines oblique subspace projections (ObSP) with the structure of a mean average system in order to define adequate signal subspaces. To guarantee smoothness in the estimated regression parameters, as observed in normal physiological processes, we impose a Tikhonov regularization using a matrix differential operator. We evaluate the performance of SIDE-ObSP by using a synthetic dataset, and present two case studies in the field of cerebral hemodynamics monitoring using NIRS. In addition, we compare the performance of this method with other system identification techniques. In the first case study data from 20 neonates during the first 3 days of life was used, here SIDE-ObSP decoupled the influence of changes in arterial oxygen saturation from the

  9. A multi-year monitoring project of the high-altitude Cenote ice cave, Dolomites, Italy

    Science.gov (United States)

    Sauro, Francesco; Santagata, Tommaso; Spötl, Christoph; Festi, Daniela; Oeggl, Klaus; Dal Molin, Luca; De Waele, Jo

    2016-04-01

    The Cenote ice cave hosts one of the most voluminous cave glaciers of the Dolomites. This 280 m-deep abyss was discovered in 1994 after the entrance had opened as a result of the abrupt emptying of a small lake at 2940 m a.s.l. in the Regional Park of Fanes, Sennes and Braies. The cave consists of a massive, 130 m-thick layered ice deposit carved by meltwater tunnels and chimneys excavated from below by ascending air. At the lower limit of the cave glacier a shaft opens - ice-free and 165 m deep - leading into a dome occupied by a cave rock glacier with typical terminal tongue embankments. A research project was launched to monitor long-term movements and volume changes of this ice deposit as well as to understand the cave microclimate and the potential for future palaeoclimate studies. During October 2015 a first expedition performed a complete survey of the final chamber using a Leica HDS7000, a phase difference laser scanner equipped with a dual axis compensator, on-board control, a wavelenght of 1.5 microns, a laser "CLASS 1" with a flow rate of 187 m and a resolution of 0.1 mm. A scan station was performed also at 110 m above the bottom of the shaft to map in detail the lower side of the hanging ice glacier. This survey has provided the detailed volume of the chamber (420,000 m3) as well as a first record of the position of the ice masses hanging on the ceiling and of the rock glacier at the bottom. Barometric, temperature and humidity dataloggers have been installed in the cave to record the microclimate. In addition pollen traps have been installed to study the present flux of pollen at the surface and inside the cave, while preliminary analyses on pollen grains preserved in the ice are being carried out. The Cenote ice cave research project aims to shed light on the climate evolution of the Dolomites during the last hundreds or possibly thousands of years, as well as on the more recent environmental changes that lead to the upward melting of the cave

  10. Using the Citizen Science Picture Post Project as the Foundation for Campus Environmental Monitoring by Undergraduate Student Researchers

    Science.gov (United States)

    Bowen, K.; Guertin, L. A.

    2014-12-01

    Penn State Brandywine is utilizing the citizen science Picture Post network as a foundation for collecting campus environmental data and for undergraduate student research investigations. The Picture Post is an environmental monitoring project a part of Digital Earth Watch, a citizen science initiative funded by NASA. Picture Post creates opportunities for educators and community members to take digital photos from octagonal platforms on posts registered as part of the Picture Post national network and then share these photos online. Penn State Brandywine joined the Picture Post project May 27, 2014, to begin a long-term monitoring program, starting with an environmental baseline of the campus landscape. Four post locations were selected on campus based upon projected major construction projects. Photos at each post are being taken by students on a weekly basis and uploaded to the Picture Post website. The campus community and beyond are also being encouraged to take their own photos to upload to the website. Instructional signage has been placed on each post, and a Penn State Brandywine Picture Post website (http://sites.psu.edu/picturepost/) has been created to explain the project and campus objectives in more detail. This project was started by a student as part of her undergraduate summer research experience and will continue to be managed by students in future semesters. With just a half-year of Picture Post photos, it is evident that there are documented changes in the environment because of construction and expected seasonal variations. The Picture Post photos have provided enough data for an initial undergraduate research project with a student analyzing and comparing the variations in the greenness factor of the photos with supplemental temperature and precipitation data. This project will continue to provide opportunities for citizen contributions to the network as well as data for student investigations of the changing campus environment.

  11. Stored CO2 and Methane Leakage Risk Assessment and Monitoring Tool Development: CO2 Capture Project Phase 2 (CCP2)

    Energy Technology Data Exchange (ETDEWEB)

    Dan Kieki

    2008-09-30

    The primary project goal is to develop and test tools for optimization of ECBM recovery and geologic storage of CO{sub 2} in coalbeds, in addition to tools for monitoring CO{sub 2} sequestration in coalbeds to support risk assessment. Three critical topics identified are (1) the integrity of coal bed methane geologic and engineered systems, (2) the optimization of the coal bed storage process, and (3) reliable monitoring and verification systems appropriate to the special conditions of CO{sub 2} storage and flow in coals.

  12. Preliminary results of radiation monitoring near uranium mines in Namibia EJOLT Project (DRAFT version)

    Energy Technology Data Exchange (ETDEWEB)

    Chareyron, Bruno

    2012-04-05

    As a part of the EJOLT (Environmental Justice Organizations Liability and Trade) project, EARTHLIFE Namibia and CRIIRAD (Commission for Independent Research and Information about Radiation) have organised visits in areas located in the vicinity of uranium mines in Namibia In the course of an on site mission carried out between September 22 and October 2 2011, scientists from the CRIIRAD laboratory took radiation measurements in situ, and collected 14 samples of top soil, 13 samples of surface sediments of the Swakop, Gawib and Khan rivers, 11 underground water samples in the alluvium of Swakop, and Khan rivers and tap water from Arandis city, and one sample of asparagus. Solid samples have been analysed at the CRIIRAD laboratory in France (measurements performed by HpGe gamma spectrometry) and water samples have been monitored for main chemicals by LDA 26 laboratory in France and for radium 226 and radon 222 at the CRIIRAD laboratory. Some of the preliminary findings are summarised in this report: 1 - The dose rate measured by CRIIRAD on the parking of Roessing mine is about 6 times above natural background value (0.9 {mu}Sv/h compared to 0.15 {mu}Sv/h); 2 - The management of waste rock dumps needs to be improved: Some waste rocks are dumped on the banks of Khan river (at the intersection with Dome Gorge) without fencing and confinement. The radiological impact of this activity has to be studied in detail but preliminary measurements show various impacts on the environment; 3 - The finest fraction of the radioactive tailings dumped on Roessing tailings dam is blown away by the wind and contaminates the surrounding environment; 4 - The high uranium concentration in underground water collected downstream Roessing uranium mine in the Khan river and Swakop river alluvium raises the question of the origin of this uranium

  13. Prognostic value of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and aminopeptidase N/CD13 in breast cancer patients.

    Science.gov (United States)

    Ranogajec, Irena; Jakić-Razumović, Jasminka; Puzović, Velibor; Gabrilovac, Jelka

    2012-06-01

    The aim of this study was to analyse the expression of matrix metalloproteinase-2(MMP-2), matrix metalloproteinase-9 (MMP-9) and aminopeptidase APN/CD13 in breast carcinoma samples, and their possible prognostic value in breast cancer patients. The expression of MMP-2, MMP-9 and APN/CD13 in tumor cells was analysed in 138 breast carcinomas by immunohistochemical staining of tumor cells using the semiquantitative method for the detection of cytoplasmic and membrane reaction in tumor cells as well as stromal cells positivity. MMP-2 was positive in tumor cells of 52.9% patients and in stromal cells of 74.6% patients, while MMP-9 positive tumor and stromal cells were found in 84.8 and 63.8% patients, respectively. Tumor cell APN/CD13 expression was found in 36.2% patients. Stromal cell MMP-2 expression correlated significantly with tumor size and neoangiogenesis. A positive correlation was also observed between tumor cell MMP-9 expression and hormone receptor status. Stromal cell coexpression of MMP-2/MMP-9 correlated significantly with tumor size. APN/CD13 expression in tumor cells significantly correlated with tumor type and neoangiogenesis. Overall survival was significantly shorter in patients with MMP-2, MMP-2/MMP-9 positive tumor cells, and tended to be shorter in patients with APN/CD13 positive tumor cells. Coexpression of MMP-2/MMP-9 in tumor cells was an independent risk factor for patient survival (OD = 13.9). Our results suggest that MMP-2, MMP-9, APN/CD13 expression and MMP-2/MMP-9 coexpression in combination with other standard prognostic factors can serve as a poor prognostic factor in the evaluation of breast cancer prognosis.

  14. A pilot project combining multispectral proximal sensors and digital cameras for monitoring tropical pastures

    Science.gov (United States)

    Handcock, Rebecca N.; Gobbett, D. L.; González, Luciano A.; Bishop-Hurley, Greg J.; McGavin, Sharon L.

    2016-08-01

    Timely and accurate monitoring of pasture biomass and ground cover is necessary in livestock production systems to ensure productive and sustainable management. Interest in the use of proximal sensors for monitoring pasture status in grazing systems has increased, since data can be returned in near real time. Proximal sensors have the potential for deployment on large properties where remote sensing may not be suitable due to issues such as spatial scale or cloud cover. There are unresolved challenges in gathering reliable sensor data and in calibrating raw sensor data to values such as pasture biomass or vegetation ground cover, which allow meaningful interpretation of sensor data by livestock producers. Our goal was to assess whether a combination of proximal sensors could be reliably deployed to monitor tropical pasture status in an operational beef production system, as a precursor to designing a full sensor deployment. We use this pilot project to (1) illustrate practical issues around sensor deployment, (2) develop the methods necessary for the quality control of the sensor data, and (3) assess the strength of the relationships between vegetation indices derived from the proximal sensors and field observations across the wet and dry seasons. Proximal sensors were deployed at two sites in a tropical pasture on a beef production property near Townsville, Australia. Each site was monitored by a Skye SKR-four-band multispectral sensor (every 1 min), a digital camera (every 30 min), and a soil moisture sensor (every 1 min), each of which were operated over 18 months. Raw data from each sensor was processed to calculate multispectral vegetation indices. The data capture from the digital cameras was more reliable than the multispectral sensors, which had up to 67 % of data discarded after data cleaning and quality control for technical issues related to the sensor design, as well as environmental issues such as water incursion and insect infestations. We recommend

  15. MMP-3和 MMP-7在上皮性卵巢癌中的表达及临床病理意义%Expression and clinicopathological significance of MMP-3、MMP-7 in epithelialovarian carcinoma

    Institute of Scientific and Technical Information of China (English)

    潘文婧; 刘巍; 谭文华

    2014-01-01

    Objective To investigate the expression of MMP-3 and MMP-7 in epithelial ovarian carcinoma and their clinicopathological significance .Mtehods Immunohistochemical method was used to detect the expression of MMP-3 and MMP-7 in 5 0 cases of epithelial ovarian carcinoma and 1 0 cases of normal ovarian tissue .Results The expression rates of MMP-3 and MMP-7 in 5 0 cases of epithelial ovarian carcinoma are significantly higher than in 1 0 cases of normal ovarian (χ2 =1 7.2 9 , P <0.0 5;χ2 =1 1.2 6 , P <0.0 5 ) .The expressions of MMP-3 and MMP-7 were in positive correlation with clinical stage (χ2=1 1.5 9 , P <0.0 0 5;χ2 =4.5 6 , P <0.0 5 ) , pathological garade (χ2 =1 6.6 2 , P <0.0 0 5;χ2=4.4 3 , P <0.0 5 ) and lymphatic-metastasis (χ2 =4.9 , P <0.0 5;χ2 =5.4 , P <0.0 5 ) , while no correlation with histological type .Conclusion The MMP-3 and MMP-7 are over-ex-pressed in ovarian carcinoma , and the expression of MMP-3 and MMP-7 relate to clinical stages , patho-logical grades and lymphatic-metastasis .The over-expression of MMP-3 and MMP-7 may play important roles in the process of carcinogenesis and progression in epithelial ovarian carcinoma .%目的:探讨基质金属蛋白酶-3(MMP-3)与基质金属蛋白酶-7(MMP-7)在上皮性卵巢癌中的表达及与卵巢癌临床病理特征之间的关系。方法采用免疫组化法对50例上皮性卵巢癌组织、10例正常卵巢组织标本中 MMP-3和 MMP-7的表达情况进行检测。结果MMP-3与 MMP-7在上皮性卵巢癌组织中的表达率明显比正常卵巢组织高,差异有统计学意义(χ2=17.29,P <0.05;χ2=11.26,P <0.05)。 MMP-3、MMP-7的阳性表达与卵巢癌的临床分期(χ2=11.59,P <0.05;χ2=4.56,P <0.05)、病理分级(χ2=16.62,P <0.05;χ2=4.43, P <0.05)显著正相关;有淋巴结转移者 MMP-3和 MMP-7的表达高于无淋巴结转移者,差异有统计学意义(χ2=4.9,P <0.05;χ2=5.4,P <0

  16. Polymorphisms of the MMP-9 gene and abdominal aortic aneurysm

    Science.gov (United States)

    Smallwood, Linda; Allcock, Richard; van Bockxmeer, Frank; Warrington, Nicole; Palmer, Lyle J; Iacopetta, Barry; Golledge, Jonathan; Norman, Paul E

    2008-01-01

    Background Increased matrix metalloproteinase-9 (MMP-9) activity has been implicated in the formation of abdominal aortic aneurysms (AAAs). The aim of the present study was to explore the association between potentially functional variants of the MMP-9 gene and AAA. Method The −1562C>T and −1811A>T variants of the MMP-9 gene were genotyped in 678 men with AAAs (>30mm in diameter) and 659 controls (aortic diameter 19−22mm) recruited from a population-based trial of screening for AAAs. The levels of MMP-9 were measured in a random subset of 300 cases and 84 controls. The association between genetic variants (including haplotypes) and AAA was assessed using multivariate logistic regression. Results There was no association between the MMP-9 −1562C>T (OR 0.70 95%CI 0.27, 1.82) or −1811A>T (OR 0.71, 95%CI 0.28, 1.85) genotypes, or the most common haplotype (OR 0.81 95%CI 0.62, 1.05), and AAA. The serum MMP-9 concentration (ng/mL) was higher in cases than controls and in minor allele carriers in cases and controls although the differences were not statistically significant. Conclusion The results suggest that a genetic tendency to have higher levels of circulating MMP-9 is not associated with AAAs. PMID:18763261

  17. EC MoDeRn Project: In-situ Demonstration of Innovative Monitoring Technologies for Geological Disposal - 12053

    Energy Technology Data Exchange (ETDEWEB)

    Breen, B.J. [NDA, Herdus House, Westlakes Science and Technology Park, Moor Row, Cumbria, CA24 3HU (United Kingdom); Garcia-Sineriz, J.L. [AITEMIN, c/Margarita Salas 14-Parque Leganes Tecnologico-Leganes, ES-28918, Madrid (Spain); Maurer, H. [ETH Zurich, ETH Honggerberg, CH-8093, Zurich (Switzerland); Mayer, S. [ANDRA, 1-7 rue Jean-Monnet, F-92298 Chatenay-Malabry cedex (France); Schroeder, T.J. [NRG, P.O. Box 25, NL-1755 ZG Petten (Netherlands); Verstricht, J. [EURIDICE EIG, c/o SCK.CEN, Boeretang 200, BE-2400 Mol (Belgium)

    2012-07-01

    Monitoring to provide information on the evolution of geological disposal presents several challenges. The 4-year, euros M 5, EC MoDeRn Project (http://www.modern-fp7.eu/), which commenced in 2009, addresses monitoring processes, state-of-the-art technology and innovative research and development of monitoring techniques. This paper discusses some of the key drivers for the development of innovative monitoring techniques and provides outlines of the demonstration programmes being conducted within MoDeRn. The aim is to develop these innovative monitoring techniques and to demonstrate them under realistic conditions present in underground laboratories. These demonstration projects, applying a range of different monitoring techniques, are being carried out at underground research facilities in different geological environments at HADES URL in Belgium (plastic clay), Bure in France (indurated clay) and at Grimsel Test Site (granite) in Switzerland. These are either built upon existing infrastructure (EC ESDRED Low pH shotcrete and TEM experiments at Grimsel; and PRACLAY experiment and underground galleries in HADES) or will be attached to infrastructure that is being developed and financed by resources outside of this project (mock-up disposal cell in Bure). At Grimsel Test Site, cross-hole and hole-to-tunnel seismic methods are being employed as a means to monitor induced changes in an artificially saturated bentonite wall confined behind a shotcrete plug. Recognising the limitations for travel-time tomography for monitoring a disposal cell, full waveform inversion techniques are being employed to enhance the capacity to monitor remote from the excavation. At the same Grimsel location, an investigation will be conducted of the potential for using a high frequency wireless (HFW) sensor network embedded within the barrier system; this will include the possibility of providing energy remotely to isolated sensors. At the HADES URL, the monitoring programme will utilise

  18. Inhibitory effect of the carnosine-gallic acid synthetic peptide on MMP-2 and MMP-9 in human fibrosarcoma HT1080 cells.

    Science.gov (United States)

    Kim, Sung-Rae; Eom, Tae-Kil; Byun, Hee-Guk

    2014-09-01

    Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade extracellular matrix components and play important roles in a variety of biological and pathological processes such as malignant tumor metastasis and invasion. In this study, we constructed carnosine-gallic acid peptide (CGP) to identify a better MMP inhibitor than carnosine. The inhibitory effects of CGP on MMP-2 and MMP-9 were investigated in the human fibrosarcoma (HT1080) cell line. As a result, CGP significantly decreased MMP-2 and MMP-9 expression levels without a cytotoxic effect. Moreover, CGP may inhibit migration and invasion in HT1080 cells through the urokinase plasminogen activator (uPA)-uPA receptor signaling pathways to inhibit MMP-2 and MMP-9. Based on these results, it appears that CGP may play an important role in preventing and treating several MMP-2 and MMP-9-mediated health problems such as metastasis.

  19. Neutrophil Gelatinase-Associated Lipocalin (NGAL), Pro-Matrix Metalloproteinase-9 (pro-MMP-9) and Their Complex Pro-MMP-9/NGAL in Leukaemias

    Energy Technology Data Exchange (ETDEWEB)

    Bouchet, Sandrine; Bauvois, Brigitte, E-mail: brigitte.bauvois@crc.jussieu.fr [INSERM U1138, Université Pierre et Marie Curie, Université Paris-Descartes, Centre de Recherche des Cordeliers, Paris 75006 (France)

    2014-04-04

    Matrix metalloproteinase (MMP)-9 and neutrophil gelatinase-associated lipocalin (NGAL) have gained attention as cancer biomarkers. The inactive zymogen form of MMP-9 (pro-MMP-9) also exists as a disulphide-linked heterodimer bound to NGAL in humans. Leukaemias represent a heterogeneous group of neoplasms, which vary in their clinical behavior and pathophysiology. In this review, we summarize the current literature on the expression profiles of pro-MMP-9 and NGAL as prognostic factors in leukaemias. We also report the expression of the pro-MMP-9/NGAL complex in these diseases. We discuss the roles of (pro)-MMP-9 (active and latent forms) and NGAL in tumour development, and evaluate the mechanisms by which pro-MMP-9/NGAL may influence the actions of (pro)-MMP-9 and NGAL in cancer. Emerging knowledge about the coexpression and the biology of (pro)-MMP-9, NGAL and their complex in cancer including leukaemia may improve treatment outcomes.

  20. Project Catch: A space based solution to combat illegal, unreported and unregulated fishing. Part I: Vessel monitoring system

    Science.gov (United States)

    Detsis, Emmanouil; Brodsky, Yuval; Knudtson, Peter; Cuba, Manuel; Fuqua, Heidi; Szalai, Bianca

    2012-11-01

    Space assets have a unique opportunity to play a more active role in global resource management. There is a clear need to develop resource management tools in a global framework. Illegal, Unregulated and Unreported (IUU) fishing is placing pressure on the health and size of fishing stocks around the world. Earth observation systems can provide fishery management organizations with cost effective monitoring of large swaths of ocean. Project Catch is a fisheries management project based upon the complimentary, but independent Catch-VMS and Catch-GIS systems. Catch-VMS is a Vessel Monitoring System with increased fidelity over existing offerings. Catch-GIS is a Geographical Information System that combines VMS information with existing Earth Observation data and other data sources to identify Illegal, Unregulated and Unreported (IUU) fishing. Project Catch was undertaken by 19 Masters students from the 2010 class of the International Space University. In this paper, the space-based system architecture of Project Catch is presented and analyzed. The rationale for the creation of the system, as well as the engineering trade-off studies in its creation, are discussed. The Catch-VMS proposal was envisaged in order to address two specific problems: (1) the expansion of illegal fishing to high-latitude regions where existing satellite systems coverage is an issue and (2) the lack of coverage in remote oceanic regions due to reliance on coastal-based monitoring. Catch-VMS utilizes ship-borne transponders and hosted-payload receivers on a Global Navigation Satellite System in order to monitor the position and activity of compliant fishing vessels. Coverage is global and continuous with multiple satellites in view providing positional verification through multilateration techniques. The second part of the paper briefly describes the Catch-GIS system and investigates its cost of implementation.

  1. Project SIMORAC: a wireless system for radiation monitoring in emergencies; Proyecto SIMORAC: Un sistema inalambrico para monitorizacion radiologica en emergencias

    Energy Technology Data Exchange (ETDEWEB)

    Gomez, D.; Serrano, J. L.; Cabrera, E.; Barbaran, J.; Llopis, L.; Diaz, M.

    2013-07-01

    The SIMORAC project includes a new system for Radiological monitoring using wireless sensor networks (RSIs), without infrastructure planning in emergency situations for a rapidly deployable by air or land, with the aim of providing a tool emergency teams capable of offering a real time x-ray map within the radius of action of an accident. Communication of quality at a great distance, resistance to weather, long autonomy and possibility of aerial deployment are some of the features of SIMORAC.

  2. Study of the Cherokee Nuclear Station: projected impacts, monitoring plan, and mitigation options for Cherokee County, South Carolina

    Energy Technology Data Exchange (ETDEWEB)

    Peelle, E.; Schweitzer, M.; Scharre, P.; Pressman, B.

    1979-07-01

    This report inventories Cherokee County's capabilities and CNS project characteristics, projects expected impacts from the interaction of the two defines four options for Cherokee County decision makers, and presents a range of possible mitigation and monitoring plans for dealing with the problems identified. The four options and general implementation guidelines for each are presented after reviewing pertinent features of other mitigation and monitoring plans. The four options include (1) no action, (2) preventing impacts by preventing growth, (3) selective growth in designated areas as services can be supplied, and (4) maximum growth designed to attract as many in-movers as possible through a major program of capital investiments in public and private services. With the exception of the no action option, all plans deal with impacts according to some strategy determined by how the County wishes to manage growth. Solutions for impact problems depend on which growth strategy is selected and what additional resources are secured during the impact period. A monitoring program deals with the problems of data and projections uncertainty, while direct action is proposed to deal with the institutional problems of delay of the needed access road, timeing and location problems from the tax base mismatch, and lack of local planning capability.

  3. Community monitoring of integrated pest management versus conventional pesticide use in a World Bank project in Indonesia.

    Science.gov (United States)

    Ishii-Eiteman, Marcia J; Ardhianie, Nila

    2002-01-01

    Pesticide Action Network North America (PANNA) collaborated with a local Indonesian nongovernmental organization (NGO), Yayasan Duta Awam (YDA), in monitoring impacts of the World Bank-financed Integrated Swamps Development Project (ISDP). This paper reports the results of the community-based investigation, which found wide disparities between the World Bank's policy on pest management and its implementation. Instead of reducing farmers' reliance on pesticides as required, the ISDP led to increased intensity and frequency of pesticide use and adverse health and environmental effects from pesticide exposures. YDA and PANNA presented the findings to the Indonesian government and World Bank officials, and farmers requested training in IPM among other recommendations. After NGOs undertook joint advocacy efforts to reduce pesticide dependence in the project, the World Bank withdrew hazardous pesticides from input packages, IPM training was initiated, and community monitors became local leaders in their villages. The study demonstrates the importance and efficacy of independent community-based monitoring in documenting pesticide problems and replacing pesticides with IPM in World Bank development projects.

  4. Expression of MMP-2 and MMP-9 in the rat trigeminal ganglion during the development of temporomandibular joint inflammation.

    Science.gov (United States)

    Nascimento, G C; Rizzi, E; Gerlach, R F; Leite-Panissi, C R A

    2013-11-18

    Orofacial pain is a prevalent symptom in modern society. Some musculoskeletal orofacial pain is caused by temporomandibular disorders (TMDs). This condition has a multi-factorial etiology, including emotional factors and alteration of the masticator muscle and temporomandibular joints (TMJs). TMJ inflammation is considered to be a cause of pain in patients with TMD. Extracellular proteolytic enzymes, specifically the matrix metalloproteinases (MMPs), have been shown to modulate inflammation and pain. The purpose of this investigation was to determine whether the expression and level of gelatinolytic activity of MMP-2 and MMP-9 in the trigeminal ganglion are altered during different stages of temporomandibular inflammation, as determined by gelatin zymography. This study also evaluated whether mechanical allodynia and orofacial hyperalgesia, induced by the injection of complete Freund's adjuvant into the TMJ capsule, were altered by an MMP inhibitor (doxycycline, DOX). TMJ inflammation was measured by plasma extravasation in the periarticular tissue (Evans blue test) and infiltration of polymorphonuclear neutrophils into the synovial fluid (myeloperoxidase enzyme quantification). MMP expression in the trigeminal ganglion was shown to vary during the phases of the inflammatory process. MMP-9 regulated the early phase and MMP-2 participated in the late phase of this process. Furthermore, increases in plasma extravasation in periarticular tissue and myeloperoxidase activity in the joint tissue, which occurred throughout the inflammation process, were diminished by treatment with DOX, a nonspecific MMP inhibitor. Additionally, the increases of mechanical allodynia and orofacial hyperalgesia were attenuated by the same treatment.

  5. Expression of MMP-2 and MMP-9 in the rat trigeminal ganglion during the development of temporomandibular joint inflammation

    Directory of Open Access Journals (Sweden)

    G.C. Nascimento

    2013-11-01

    Full Text Available Orofacial pain is a prevalent symptom in modern society. Some musculoskeletal orofacial pain is caused by temporomandibular disorders (TMDs. This condition has a multi-factorial etiology, including emotional factors and alteration of the masticator muscle and temporomandibular joints (TMJs. TMJ inflammation is considered to be a cause of pain in patients with TMD. Extracellular proteolytic enzymes, specifically the matrix metalloproteinases (MMPs, have been shown to modulate inflammation and pain. The purpose of this investigation was to determine whether the expression and level of gelatinolytic activity of MMP-2 and MMP-9 in the trigeminal ganglion are altered during different stages of temporomandibular inflammation, as determined by gelatin zymography. This study also evaluated whether mechanical allodynia and orofacial hyperalgesia, induced by the injection of complete Freund's adjuvant into the TMJ capsule, were altered by an MMP inhibitor (doxycycline, DOX. TMJ inflammation was measured by plasma extravasation in the periarticular tissue (Evans blue test and infiltration of polymorphonuclear neutrophils into the synovial fluid (myeloperoxidase enzyme quantification. MMP expression in the trigeminal ganglion was shown to vary during the phases of the inflammatory process. MMP-9 regulated the early phase and MMP-2 participated in the late phase of this process. Furthermore, increases in plasma extravasation in periarticular tissue and myeloperoxidase activity in the joint tissue, which occurred throughout the inflammation process, were diminished by treatment with DOX, a nonspecific MMP inhibitor. Additionally, the increases of mechanical allodynia and orofacial hyperalgesia were attenuated by the same treatment.

  6. Did dead animals really spew from the IEA-GHG Weyburn-Midale CO2 monitoring and storage project?

    Science.gov (United States)

    Rostron, B. J.; IEA-GHG Weyburn-Midale CO2 Project, T.; Theme Leaders: IEA-GHG Weyburn-Midale CO2 Monitoring; Storage Project

    2011-12-01

    The IEA-GHG Weyburn-Midale CO2 monitoring and storage project was initiated in 2000 to study the geological storage of CO2 as part of a CO2-EOR project in the Weyburn Field in Saskatchewan, Canada. Initial injection of CO2 began in October 2000, and continues to date, with more than 18 Mtonnes of anthropogenic CO2 stored in the Weyburn reservoir. In January 2011, a local landowner supported by a consultant's soil gas survey, claimed they had conclusive proof that the "source of the high concentrations of CO2 in soils ... is clearly the anthropogenic CO2 injected into the Weyburn reservoir". These claims quickly attracted local, provincial, national, and international media attention alerting the world to the "leakage" at the Weyburn CO2-EOR project and furthermore calling into question the safety of geological CO2 sequestration in general. A careful look at the data reveals a different story. Twenty six soil gas samples were collected in August 2010, from shallow (Weyburn-Midale research project, do not support the claim(s) of anthropogenic CO2 leakage from the Weyburn reservoir. A comprehensive geological, geophysical, hydrogeological, and geochemical site characterization combined with background and on-site soil gas monitoring, integrated with numerical simulations of CO2 movement has not detected any evidence of migration of CO2 above the regional subsurface seal. Shallow soil gas monitoring near the Weyburn field, and in the CO2-EOR area, have detected transient elevated CO2 concentrations of similar magnitudes. Previously published 13C/12C data from shallow aquifers in Saskatchewan match those obtained by the consultant. None of the observed geochemical parameter values fall outside the background ranges expected for this area. Phenomena observed at this site can be explained by near surface processes including microbial generation of soil CO2 and methane. This talk will highlight relevant data collected by the research project and contrast it with claims of

  7. The INSIDE project: on-line monitoring and simulation validation with the in-beam PET scanner

    Science.gov (United States)

    Ferrero, V.; INSIDE Collaboration

    2017-05-01

    The quality assurance of particle therapy treatment is a fundamental issue that can be addressed by developing reliable monitoring techniques and indicators of the treatment plan accuracy. Monitoring using Position Emission Tomography (PET) systems is the only in-vivo non invasive technique employed clinically and has been carried out in particle therapy since 1997. However, the PET monitoring of β + emitter isotopes is typically done after the treatment, resulting in a large fraction of lost data because of the isotopes rapid physical decay. The INSIDE collaboration has recently installed an in-beam PET scanner at the Italian National Center of Oncologic Hadrontherapy in Pavia, Italy. Here, there is an ongoing project in order to start testing the method on patients. This work focuses on the online performances of the scanner with clinical beams.

  8. Ovarian Membrane-Type Matrix Metalloproteinases: Induction of MMP14 and MMP16 During the Periovulatory Period in the Rat, Macaque, and Human1

    Science.gov (United States)

    Puttabyatappa, Muraly; Jacot, Terry A.; Al-Alem, Linah F.; Rosewell, Katherine L.; Duffy, Diane M.; Brännström, Mats; Curry, Thomas E.

    2014-01-01

    ABSTRACT An intrafollicular increase in proteolytic activity drives ovulatory events. Surprisingly, the periovulatory expression profile of the membrane-type matrix metalloproteinases (MT-MMPs), unique proteases anchored to the cell surface, has not been extensively examined. Expression profiles of the MT-MMPs were investigated in ovarian tissue from well-characterized rat and macaque periovulatory models and naturally cycling women across the periovulatory period. Among the six known MT-MMPs, mRNA expression of Mmp14, Mmp16, and Mmp25 was increased after human chorionic gonadotropin (hCG) administration in rats. In human granulosa cells, mRNA expression of MMP14 and MMP16 increased following hCG treatment. In contrast, mRNA levels of MMP16 and MMP25 in human theca cells were unchanged before ovulation but declined by the postovulatory stage. In macaque granulosa cells, hCG increased mRNA for MMP16 but not MMP14. Immunoblotting showed that protein levels of MMP14 and MMP16 in rats increased, similar to their mRNA expression. In macaque granulosa cells, only the active form of the MMP14 protein increased after hCG, unlike its mRNA or the proprotein. By immunohistochemistry, both MMP14 and MMP16 localized to the different ovarian cell types in rats and humans. Treatment with hCG resulted in intense immunoreactivity of MMP14 and MMP16 proteins in the granulosa and theca cells. The present study shows that MMP14 and MMP16 are increased by hCG administration in the ovulating follicle, demonstrating that these MMPs are conserved among rats, macaques, and humans. These findings suggest that MT-MMPs could have an important role in promoting ovulation and remodeling of the ovulated follicle into the corpus luteum. PMID:24920038

  9. British Columbia S-2000 monitoring project. Volume 1: Performance summary interim report for the period June 1993 to December 1993

    Energy Technology Data Exchange (ETDEWEB)

    Makuch, P.D.; Harrison, S.J

    1994-02-01

    The Canadian S-2000 program was established to provide utilities with comprehensive field trials of solar domestic hot water (SDHW) heating systems, which have been identified as potentially able to provide significant energy savings. The main objective of S-2000 is to promote cooperation between governments and electrical utilities interested in evaluating whether SDHW systems are suited to utility load management goals, particularly the reduction of peak demand levels and pollutant emission control through cost-effective energy displacement. Current activity in the program consists of cooperative government/utility pilot projects to install and monitor several SDHW systems across Canada. As a first step to demonstrate the potential of SDHW in British Columbia, eight systems were purchased by provincial utilities, installed at private residences, and monitored. The monitoring results over the June-December 1993 period are summarized. Six of the systems are functioning as expected and show an average solar fraction of 42.2% over the monitoring period. These systems show good agreement with predicted results, but the two remaining systems are operating below projected levels due to equipment malfunctions. Only three of the systems had a daily load greater than the 239 l/d average for a typical Canadian family. Calculations indicate that a home using 350 l/d of hot water and a properly oriented collector should get 45.7% of the hot water heating load from solar energy (11.1 GJ of the 27.3 GJ total annual load). 4 refs., 18 figs., 11 tabs.

  10. Sustainable and non-conventional monitoring systems to mitigate natural hazards in low income economies: the 4onse project approach.

    Science.gov (United States)

    Cannata, Massimiliano; Ratnayake, Rangajeewa; Antonovic, Milan; Strigaro, Daniele

    2017-04-01

    Environmental monitoring systems in low economies countries are often in decline, outdated or missing with the consequence that there is a very scarce availability and accessibility to these information that are vital for coping and mitigating natural hazards. Non-conventional monitoring systems based on open technologies may constitute a viable solution to create low cost and sustainable monitoring systems that may be fully developed, deployed and maintained at local level without lock-in dependances on copyrights or patents or high costs of replacements. The 4onse research project , funded under the Research for Development program of the Swiss National Science Foundation and the Swiss Office for Development and Cooperation, propose a complete monitoring system that integrates Free & Open Source Software, Open Hardware, Open Data, and Open Standards. After its engineering, it will be tested in the Deduru Oya catchment (Sri Lanka) to evaluate the system and develop a water management information system to optimize the regulation of artificial basins levels and mitigate flash floods. One of the objective is to better scientifically understand strengths, criticalities and applicabilities in terms of data quality; system durability; management costs; performances; sustainability. Results, challenges and experiences from the first six months of the projects will be presented with particular focus on the activities of synergies building and data collection and dissemination system advances.

  11. Flexible High Energy-Conversion Sensing Materials for Structural Health Monitoring Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The applicant is developing flexible highly-efficient piezoelectric materials for use in structural health monitoring (SHM) as contemplated in the solicitation...

  12. Highly Reliable Structural Health Monitoring of Smart Composite Vanes for Jet Engine Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Intelligent Fiber Optic Systems and Auburn University propose a Fiber Bragg Grating (FBG) integrated Structural Health Monitoring (SHM) sensor system capable of...

  13. Highly Reliable Structural Health Monitoring of Smart Composite Vanes for Jet Engine Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In Phase 1, Intelligent Fiber Optic Systems (IFOS) successfully demonstrated a Fiber Bragg Grating (FBG) based integrated Structural Health Monitoring (SHM) sensor...

  14. Structural Health Monitoring with Fiber Bragg Grating and Piezo Arrays Project

    Data.gov (United States)

    National Aeronautics and Space Administration — IFOS and its research institute collaborator, Washington State University (WSU), have demonstrated feasibility of a structural health monitoring (SHM) system for...

  15. Nonlinear guided wave circular array system for microcrack monitoring in spacecraft Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Reliable monitoring of the microcrack formation in the complex composite structure components in NASA spacecraft and launch vehicles is critical for vehicle...

  16. Bone mineral density, Bone mineral contents, MMP-8 and MMP-9 levels in Human Mandible and alveolar bone: Simulated microgravity

    Science.gov (United States)

    Rai, Balwant; Kaur, Jasdeep; Catalina, Maria

    Exposure to microgravity has been associated with several physiological changes in astronauts and cosmonauts, including an osteoporosis-like loss of bone mass. It has been reported that head-down tilt bed-rest studies mimic many of the observations seen in flights. There is no study on the correlation on effects of mandibular bone and alveolar bone loss in both sex in simulating microgravity. This study was designed to determine the Bone mineral density and GCF MMP-8 MMP-9 in normal healthy subject of both sexes in simulated microgravity condition of -6 head-down-tilt (HDT) bed rest. The subjects of this investigation were 10 male and 10 female volunteers participated in three weeks 6 HDT bed-rest exposure. The Bone density and bone mineral contents were measured by dual energy X-ray absorptiometry before and in simulated microgravity. The GCF MMP-8 MMP-8 were measured by Enzyme-linked immunosorbent assays (Human Quantikine MMP-8,-9 ELISA kit). The bone mineral density and bone mineral contents levels were significantly decreased in simulated microgravity condition in both genders, although insignificantly loss was higher in females as compared to males. MMP-8 MMP-9 levels were significantly increased in simulated microgravity as compared to normal condition although insignificantly higher in females as compared to males. Further study is required on large samples size including all factors effecting in simulated microgravity and microgravity. Keys words-Simulated microgravity condition, head-down-tilt, Bone loss, MMP-8, MMP-9, Bone density, Bone mineral contents.

  17. Monitoring systems and their effectiveness for project cost control in construction

    NARCIS (Netherlands)

    Al-Jibouri, Saad H.

    2002-01-01

    This paper reports on a research to investigate the effectiveness of some commonly used monitoring systems, in detecting deviations from the planned cost and performance. The monitoring systems used in this work are: Leading parameter technique Variances method Activity based ratios technique Th

  18. 肺癌患者血清MMP-9和TIMP-1检测的临床意义%The clinical significance of the measurement of serum MMP-9 and TIMP-1 in patients with lung cancer

    Institute of Scientific and Technical Information of China (English)

    王小军; 火云霞; 刘华; 李伟华; 潘辉; 蔡曦光

    2013-01-01

    Objective To investigate the serum expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of matrix metalloproteinase-l(TIMP-l) in lung cancer patients and healthy people,and its relationship with clinical pathological features, including staging, the degree of tumor differentiation, the size of tumor, the lymph node metastasis status and distant metastasis, etc. Methods The serum expression of MMP-9 and TIMP-1 in lung caner patients and healthy people were tested by ELISA and analyzed statistically. Results The serum expression of MMP-9 and TIMP-1 in lung caner patients were significantly higher than that of healthy people (P0. 05). Conclusion MMP-9 and TIMP-1 may take part in the progress of lung cancer,and could be used as clinical indicators to monitor the development of disease.%目的 研究基质金属蛋白酶-9(MMP-9)和组织金属蛋白酶抑制剂-1(TIMP-1)在肺癌患者和健康人血清中的含量,及其与分期、肿瘤分化程度、肿瘤大小、淋巴结转移状态、远处转移等病理特征的相关性.方法 通过酶联免疫吸附测定(ELISA)分别检测肺癌患者和健康对照者的血清样本中的MMP-9、TIMP-1的浓度,进行统计学分析.结果 MMP-9和TIMP-1在肺癌患者血清中的含量明显高于健康人群,差异有统计学意义(P<0.01);并与分期、肿瘤大小、淋巴结转移、远处转移呈正相关(P<0.05),与分化程度呈负相关(P<0.05);而与年龄、性别、吸烟史、肿瘤的病理类型无关(P>0.05).结论 MMP-9和TIMP-1参与肺癌的发生、发展、侵袭转移过程,可作为临床监测病情发展的指标.

  19. Atmosphere Resource Recovery & Environmental Monitoring (ARREM) for Long Duration Exploration Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The project focuses on key physico-chemical process technologies for Atmosphere Revitalization Systems (ARS) that increase reliability, capability, and consumable...

  20. Fluorogenic MMP activity assay for plasma including MMPs complexed to α2-macroglobulin

    NARCIS (Netherlands)

    Beekman, B.; Drijfhout, J.W.; Ronday, H.K.; TeKoppele, J.M.

    1999-01-01

    Elevated MMP activities are implicated in tissue degradation in, e.g., arthritis and cancer. The present study was designed to measure MMP enzyme activity in plasma. Free active MMP is unlikely to be present in plasma: upon entering the circulation, active MMP is expected to be captured by the prote

  1. Fluorogenic MMP activity assay for plasma including MMPs complexed to α2-macroglobulin

    NARCIS (Netherlands)

    Beekman, B.; Drijfhout, J.W.; Ronday, H.K.; TeKoppele, J.M.

    1999-01-01

    Elevated MMP activities are implicated in tissue degradation in, e.g., arthritis and cancer. The present study was designed to measure MMP enzyme activity in plasma. Free active MMP is unlikely to be present in plasma: upon entering the circulation, active MMP is expected to be captured by the

  2. Association of MMP-9 gene polymorphisms with nephrolithiasis patients.

    Science.gov (United States)

    Mehde, Atheer Awad; Mehdi, Wesen Adel; Yusof, Faridah; Raus, Raha Ahmed; Zainal Abidin, Zaima Azira; Ghazali, Hamid; Abd Rahman, Azlina

    2017-02-15

    Nephrolithiasis is one of the causes which lead to chronic kidney disease (CKD). Matrix metalloproteinases (MMPs) are endopeptidases degrading extracellular matrix which correlate with the pathogenesis of atherosclerosis. The current study was designed to analyze the association of (R279Q, C1562T) polymorphism of MMP-9 with nephrolithiasis patients. Genotyping of MMP-9/R279Q and of MMP-9/C1562T polymorphism were carried out by PCR-based restriction digestion method. Serum level of MMP-9, oxidative stress marker, MDA, and uric acid were measured in patients and control. Allele frequencies of the MMP-9/C1562T polymorphism for C and T allele were 71.25% and 28.75% in patients, 87.08% and 12.92% in control respectively. The homozygote TT was more frequent in the nephrolithiasis patients group, while T allele frequency was significantly higher in the nephrolithiasis patients group than in the control group. The patients with CT and TT genotype showed a significant increase in serum MMP-9, Total Oxidant Status (TOS), Oxidative Stress Index (OSI), Malondialdehyde (MDA), and uric acid when compared to CC genotype in patients with nephrolithiasis. The R279Q polymorphism site with regard to the relationship with nephrolithiasis was not significant. The result indicates that patients with TT genotype had an increased risk of stones. Also, the results demonstrate that TT allele of the C1562T polymorphism in the MMP-9gene is related with an increase of oxidative stress in nephrolithiasis patients and may possibly impose a risk for cardiovascular diseases in patients with TT genotype of MMP-9. © 2017 Wiley Periodicals, Inc.

  3. The Multi-Isotope Process Monitor Project: FY11 Progress and Accomplishments

    Energy Technology Data Exchange (ETDEWEB)

    Orton, Christopher R.; Fraga, Carlos G.; Hayes, John W.; Schwantes, Jon M.; Bender, Sarah E.; Unlu, Kenan; Dayman, Kenneth J.; Schreiber, S. S.; Landsberger, Sheldon

    2012-08-01

    Summary The Multi-Isotope Process (MIP) Monitor represents a potentially new and efficient approach to monitoring process conditions in reprocessing facilities with the high-level goal of aiding in the “...(minimization of) the risks of nuclear proliferation and terrorism” (Office of Technology Assessment 1995). This approach relies on multivariate analysis and gamma spectroscopy of spent fuel product and waste streams to automatically and simultaneously monitor a variety of process conditions (e.g., acid concentrations, burnup, cooling time, etc.) in near real-time (NRT). While the conceptual basis for the MIP Monitor has been shown to be effective in an aqueous reprocessing system, the fundamental approach should also be viable in a pyro-processing recycle system. The MIP Monitor may be calibrated to provide online quantitative information about process variables for process control or domestic safeguards applications; or it can simply monitor, with a built-in information barrier, for off-normal conditions in process streams, making the approach well-suited for applications were it is necessary to respect proprietary information or for international safeguards applications. Proof-of-concept simulations and experiments were performed in previous years demonstrating the validity of this tool in a laboratory setting. This report details follow-on research and development efforts sponsored by the U.S. Department of Energy Fuel Cycle Research and Development (FCR&D) related to the MIP Monitor for fiscal year 2011 (FY11).

  4. 血清MMP-2、MMP-9水平与非小细胞肺癌转移关系的研究%Correlation of serum total MMP-2,MMP-9 levels with human non-small cell lung cancer metastasis

    Institute of Scientific and Technical Information of China (English)

    雷建灵; 赵全年; 刘利; 高德荣

    2010-01-01

    目的 探讨非小细胞肺癌(NSCLC)患者血清MMP-2、MMP-9水平与非小细胞肺癌的关系.方法 采用ELISA法检测70例非小细胞肺癌患者及26例健康志愿者血清MMP-2和MMP-9水平.结果 NSCLC患者血清MMP-2和MMP-9含量显著高于正常对照组.NSCLC有转移组血清MMP-2和MMP-9水平显著高于 NSCLC无转移组.结论 血清MMP-2和MMP-9的水平可作为预测非小细胞肺癌转移的指标.

  5. The Multi-Isotope Process (MIP) Monitor Project: FY12 Progress and Accomplishments

    Energy Technology Data Exchange (ETDEWEB)

    Coble, Jamie B.; Orton, Christopher R.; Jordan, David V.; Schwantes, Jon M.; Bender, Sarah; Dayman, Kenneth J.; Unlu, Kenan; Landsberger, Sheldon

    2012-09-27

    The Multi-Isotope Process (MIP) Monitor, being developed at Pacific Northwest National Laboratory (PNNL), provides an efficient approach to monitoring the process conditions in reprocessing facilities in support of the goal of "...(minimization of) the risks of nuclear proliferation and terrorism." The MIP Monitor measures distributions of a suite of indicator (radioactive) isotopes present within product and waste streams of a nuclear reprocessing facility. These indicator isotopes are monitored on-line by gamma spectrometry and compared, in near-real-time, to spectral patterns representing "normal" process conditions using multivariate pattern recognition software. The monitor utilizes this multivariate analysis and gamma spectroscopy of reprocessing streams to detect small changes in the gamma spectrum, which may indicate changes in process conditions. Multivariate analysis methods common in chemometrics, such as principal component analysis (PCA) and partial least squares regression (PLS), act as pattern recognition techniques, which can detect small deviations from the expected, nominal condition. By targeting multiple gamma-emitting indicator isotopes, the MIP Monitor approach is compatible with the use of small, portable, relatively high-resolution gamma detectors that may be easily deployed throughout an existing facility. The automated multivariate analysis can provide a level of data obscurity, giving a built-in information barrier to protect sensitive or proprietary operational data. Proof-of-concept simulations and experiments have been performed in previous years to demonstrate the validity of this tool in a laboratory setting. Development of the MIP Monitor approach continues to evaluate the efficacy of the monitor for automated, real-time or near-real-time application. This report details follow-on research and development efforts sponsored by the U.S. Department of Energy Fuel Cycle Research and Development related to the MIP Monitor for fiscal year

  6. Communication Pathways in the Light Water Reactor Sustainability Online Monitoring Project

    Energy Technology Data Exchange (ETDEWEB)

    Nancy J. Lybeck; Magdy S. Tawfik; Binh T. Pham; Vivek Agarwal; Jamie Coble

    2011-09-01

    Implementation of online monitoring and prognostics in existing U.S. nuclear power plants will involve coordinating the efforts of national laboratories, utilities, universities, and private companies. Large amounts of operational data, including failure data, are necessary for the development and calibration of diagnostic and prognostic algorithms. The ability to use data from all available resources will provide the most expeditious avenue to implementation of online monitoring in existing NPPs; however, operational plant data are often considered proprietary. Secure methods for transferring and storing data are discussed, along with a potential technology for implementation of online monitoring.

  7. Technology projects for characterization--monitoring of volatile organic compounds (VOCs)

    Energy Technology Data Exchange (ETDEWEB)

    Junk, G.A.; Haas, W.J. Jr.

    1992-07-01

    One hundred thirty technology project titles related to the characterization of volatile organic compounds (VOCs) at an arid site are listed alphabetically by first contact person in a master compilation that includes phone numbers, addresses, keywords, and short descriptions. Separate tables are presented for 62 field-demonstrated, 36 laboratory-demonstrated, and 35 developing technology projects. The technology projects in each of these three categories are also prioritized in separate summary tables. Additional tables are presented for a number of other categorizations of the technology projects: In Situ; Fiberoptic; Mass Spectrometer; Optical Spectroscopy; Raman or SERS; Ion Mobility or Acoustic; Associated; and Commercial. Four lists of contact person names are provided so details concerning the projects that deal with sampling, and VOCs in gases, waters, and soils (sediments) can be obtained. Finally, seven wide-ranging conclusions based on observations and experiences during this work are presented.

  8. Effect of human osteopontin on proliferation, transmigration and expression of MMP-2 and MMP-9 in osteosarcoma cells

    Institute of Scientific and Technical Information of China (English)

    刘思金; 胡国法; 刘亚军; 刘思国; 高虹; 张传生; 魏影允; 薛延; 劳为德

    2004-01-01

    Background To explore the effect of human osteopontin (hOPN) on the proliferation, transmigration and expression of matrix metallproteinase-2 (MMP-2) and matrix metallproteinase-9 (MMP-9) in osteosarcoma (OS) cells in vitro. Methods The prokaryotic-expression vector of hOPN was produced, hOPN was then subcloned into E. coli BL21 (DE3) cells and purified with ProBondTM Columns. The proliferation, cell cycle and the expression of cyclin A in OS cells were investigated by using MTT assay, flow cytometry and Western blot respectively. The transmigration of OS cells was checked by using transwell cell culture chamber. The micro-pore-filter-membrane system was used to study the chemiotaxis of hOPN to OS cells. The levels of total protein were examined according to Coomassie Brilliant Blue manuals. The expression of MMP-2 and MMP-9 were evaluated by detecting the volume of degradation of gelatin on SDS-PAGE gel.Results The prokaryotic-expression vector of hOPN and purified hOPN protein were achieved hOPN promoted OS cells proliferation in a dose-dependent manner, and stimulated cyclin A expression in OS cells to accelerate cell division cycle, hOPN facilitated the trans-membrane migration of OS cells. hOPN also enhanced the secretion of MMP-2 and MMP-9 in OS cells. Conclusion hOPN could stimulate cyclin A expression in OS cells, hOPN has chemiotaxis to OS cells and increases their transmigration, hOPN enhances the secretion of MMP-2 and MMP-9 in OS cells.

  9. European collaboration for improved monitoring of Icelandic volcanoes: Status of the FUTUREVOLC project after the initial 18 months

    Science.gov (United States)

    Dumont, Stéphanie; Parks, Michelle; Sigmundsson, Freysteinn; Vogfjörð, Kristín; Einarsdóttir, Heiðveig Maria; Tumi Gudmundsson, Magnús; Kristinsson, Ingvar; Loughlin, Sue; Ilyinskaya, Evgenia; Hooper, Andrew; Kylling, Arve; Witham, Claire; Bean, Chris; Braiden, Aoife; Ripepe, Maurizio; Prata, Fred; Pétur Heiðarsson, Einar; Other Members Of The Futurevolc Team

    2014-05-01

    The FUTUREVOLC project funded by the European Union (FP7) is devoted to volcanic hazard assessment and establishing an integrated volcanological monitoring procedure through a European collaboration. To reach these objectives the project combines broad expertise from 26 partners from 10 countries, focusing on the four most active volcanoes of Iceland: Grímsvötn, Katla, Hekla and Bárdarbunga. The geological setting of Iceland, the high rate of eruptions and the various eruption styles make this country an optimal natural laboratory to study volcanic processes from crustal depths to the atmosphere. The project, which began on 1 October 2012, integrates advanced monitoring and analytical techniques in an innovative way, focusing on (i) detailed monitoring to improve our understanding of the seismic/magmatic unrest, in order to estimate the amount of magma available for an eruption and to provide early warnings (ii) the dynamics of magma in the conduit and a near real time estimation of the mass eruption rate and (iii) observing and modelling the plume dynamics. The project design considers effective collaboration between partners and aims for efficient cross-disciplinary workflows. A major step during the first 18 months of the project was the installation of additional equipment in the volcanic regions of Iceland to reinforce and complement the existing monitoring. The instruments include: seismometers, GPS stations, MultigGAS detectors, DOAS, infrasonic arrays, electric field sensors, radars, and optical particle sizers. Data streaming is designed to withstand extreme weather conditions. The FUTUREVOLC project has an open data policy for real and near-time data. Implementation of a data hub is currently under way, based on open access to data from the 2010 Eyjafjallajökull eruption. Access to volcano monitoring data through a common interface will allow timely information on magma movements facilitated through combined analysis. A key part of the project is to

  10. 脑室出血早产儿血浆MMP-2和MMP-9测定的临床意义%Significance of detection of plasma MMP-2 and MMP-9 in diagnosis of the periventricular hemorrhage intraventricular hemorrhage premature infants

    Institute of Scientific and Technical Information of China (English)

    江明荣; 黄循斌; 谢晓彬; 周曙明

    2012-01-01

    Objective To investigate the clinical significance of detection of plasma MMP-2 and MMP-9 in dangosis of the periventricular hemorrhage-intraventricular hemorrhage (PVH-IVH) premature infants. Methods ELISA method was to determine the contents of MMP-2 and MMP-9 in blood plasma of 40 premature infants and 20 controls premature infants without the complication of intracranial hemorrhage,etc. Results The contents of MMP-2 and MMP-9 in premature infants with PVH-IVH was significantly higher than those of the control group (P < 0.01 )and the contents of MMP-2 and MMP-9 increaed ohviously with the bleeding degree aggravation. Conclusion The change of contents of MMP-2 and MMP-9 in blood plasma disclose tge early occurrence and injury extent of PVH-IVH.%目的 探讨血浆基质金属蛋白酶-2和9(MMP-2、MMP-9)在早产儿脑室周围-脑室内出血(PVH-IVH)时的临床意义.方法 采用ELISA法测定早产儿脑室周围-脑室内出血患儿及20例对照组早产儿(无颅内出血等并发症)血浆MMP-2、MMP-9含量.结果 PVH-IVH患儿MMP-2、MMP-9比对照组早产儿显著升高(均P<0.01),随着出血程度加重,血浆MMP-2、MMP-9均明显升高(均P<0.01).结论 血浆MMP-2和MMP-9含量的变化,可客观早期的判断PVH-IVH的发生、损伤程度.

  11. Matrix metalloproteinases 2 and 9 and MMP9/NGAL complex activity in women with PCOS.

    Science.gov (United States)

    Ranjbaran, Javad; Farimani, Marzieh; Tavilani, Heidar; Ghorbani, Marzieh; Karimi, Jamshid; Poormonsefi, Faranak; Khodadadi, Iraj

    2016-04-01

    It is believed that matrix metalloproteinases (MMPs) play important roles in follicular development and pathogenesis of polycystic ovary syndrome (PCOS). However, conflicting results are available about the alteration of MMP2 and MMP9 concentrations or activities in PCOS. In fact, there is no study entirely investigating both concentration and activity of these MMPs and serum levels of their tissue inhibitors TIMP2 and TIMP1, as well as lipocalin-bound form of MMP9 (MMP9/NGAL). Therefore, the thoroughness of previous studies is questionable. This study was conducted to determine circulatory concentration of MMP2, MMP9, MMP9/NGAL complex, TIMP1 and TIMP2 as well as gelatinase activities of MMP2, MMP9 and MMP9/NGAL complex in women with PCOS and controls. Mean age and BMI as well as serum levels of total cholesterol, triacylglycerol, HDL-C, LDL-C, fasting blood sugar (FBS), insulin, estradiol and sex hormone-binding globulin did not differ between groups, whereas a marked decrease in FSH and significant increases in LH, LH/FSH ratio, testosterone and free androgen index were observed. Women with PCOS and controls showed closed concentrations of MMP2, MMP9, MMP9/NGAL, TIMP1 and TIMP2. Gelatinase activity of MMP9 was found significantly higher in PCOS than in controls (64.53±15.32 vs 44.61±18.95 respectively) while patients and healthy subjects showed similar activities of MMP2 and MMP9/NGAL complex. Additionally, PCOS patients showed a higher MMP9/TIMP1 ratio compared with control women. Direct correlations were also observed between circulatory MMP9 level and the concentration and activity of MMP9/NGAL complex. In conclusion, based on the results of present study, we believe that MMP9 may be involved in the pathogenesis of PCOS.

  12. Time Reversal Acoustic Structural Health Monitoring Using Array of Embedded Sensors Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Time Reversal Acoustic (TRA) structural health monitoring with an embedded sensor array represents a new approach to in-situ nondestructive evaluation of air-space...

  13. Space Qualified Non-Destructive Evaluation and Structural Health Monitoring Technology Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NextGen Aeronautics is proposing an innovative space qualified non-destructive evaluation and health monitoring technology. The technology is built on concepts...

  14. In-Situ Real-Time Temperature Monitoring of Thermal Protection Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This program addresses the need for interfacial and in-depth temperature monitoring of thermal protection systems (TPS). Novel, linear drive, eddy current methods...

  15. A Miniaturized Sensor for Microbial Monitoring of Spacecraft Water Environment Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Accurate real-time microbial monitoring of water environment is of paramount importance to crew health as well as to ensure proper functioning and control of the...

  16. Unpowered Wireless Ultrasound Generation and Sensing for Structural Health Monitoring of Composites Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Damage detection based on ultrasonic waves is one of the most popular inspection schemes employed by many structural health monitoring (SHM) systems. We propose a...

  17. Use of the Operational Air Quality Monitor (AQM) for In-Flight Water Testing Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Currently, the Air Quality Monitor (AQM) on-board ISS provides specific information for a number of target compounds in the air. However, there is a significant...

  18. Tunable Laser Development for In-flight OFDR Structural Health Monitoring Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Development of a cost-effective, robust, tunable, miniaturized, ruggedized, and flight tested swept laser for in-flight structural health monitoring. The objective...

  19. A Miniaturized Sensor for Microbial Monitoring of Spacecraft Water Environment Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Accurate real-time microbial monitoring of water environment is of paramount importance to crew health as well as to ensure proper functioning and control of the...

  20. Aircraft Engine Life-Consumption Monitoring for Real-Time Reliability Determination Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The object of this research is to develop an in-service life-monitor system for the prediction of the remaining component and system life of aircraft engines. The...

  1. In-Service Aircraft Engine System Life Monitor Using Advanced Life-Estimating Technique Project

    Data.gov (United States)

    National Aeronautics and Space Administration — It is proposed to develop an accurate in-service aircraft engine life monitor system for the prediction of remaining component and system life for aircraft engines....

  2. Lightweight, Wearable Metal Rubber-Textile Sensor for In Situ Lunar Autonomous Health Monitoring Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NanoSonic proposes to develop a low-weight, non-invasive in situ autonomous health-monitoring system for crewmembers' lunar extravehicular activity (EVA). This novel...

  3. Combustion/Emission Species Monitoring Ground and Flight Aeronautical Research Using a Gas Microsensor Array Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The goal of this program is to develop a miniaturized and in-situ operated gas microsensor array for the real time monitoring of chemical composition of turbine...

  4. Ullage Compatible Optical Sensor for Monitoring Safety-Significant Malfunctions Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The tasks of this Phase I proposal are designed to establish the feasibility of an optical sensor for real-time, in situ monitoring of the ullage environment of an...

  5. High Sensitivity Pulsed Laser Vibrometer for Aircraft Interior Noise Monitoring Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose an innovative pulsed laser vibrometer technology for the monitoring of interior noise inside an aircraft. The optical speckle-tolerant nature of the...

  6. Lightweight, Wearable Metal Rubber-Textile Sensor for In-Situ Lunar Autonomous Health Monitoring Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This NASA Phase II SBIR program would develop comfortable garments with multiple integrated sensor functions for the monitoring of astronauts during long duration...

  7. Data Description Exchange Services for Heterogeneous Vehicle and Spaceport Control and Monitor Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — CCT has designed and prototyped, as part of the Phase-1 SBIR, a generic platform independent software capability for exchange of semantic control and monitoring...

  8. 人参皂甙Rg3对乳腺癌细胞表达MMP-2和MMP-9的影响

    Institute of Scientific and Technical Information of China (English)

    李博; 杨威; 郑永晨; 杨艳秋

    2005-01-01

    目的研究人参皂甙Rg3对乳腺癌细胞(MCF-7细胞)分泌的基质金属蛋白酶(MMP-2,MMP-9)表达的影响.方法采用酶谱法测定了人参皂甙Rg3对乳腺癌细胞(MCF-7)细胞分泌基质金属蛋白酶(MMP-2,MMP-9)的影响.结果酶谱分析表明人参皂甙Rg3能减少MCF-7细胞分泌MMP-2,MMP-9(P<0.05).结论人参皂甙Rg3能抑制MMP-2和MMP-9的分泌.

  9. MMP-1和MMP-2在肝纤维化组织中的表达和意义

    Institute of Scientific and Technical Information of China (English)

    安运卿; 马天江

    2003-01-01

    目的:探讨MMP-1和MMP-2在肝纤维化组织中的作用及其机制.方法:应用免疫组化法并用图像分析技术定量检测28例手术切除的肝纤维化组织标本中MMP-1和MMP-2的表达.结果:正常肝组织与肝纤维化组织MMP-1表达无显著性差异(P>0.05),而MMP-2的表达在肝纤维化组织中明显高于正常肝组织(P<0.01).结论:MMP-1和MMP-2可能在肝纤维化的发生和发展中有重要作用.

  10. The SUCIMA project: A status report on high granularity dosimetry and proton beam monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Caccia, M. [Dipartimento di Scienze CC.FF.MM., Universita dell' Insubria, Como (Italy)]. E-mail: Massimo.Caccia@uninsubria.it; Badano, L. [Fondazione per Adroterapia Oncologica, Novara (Italy); Berst, D. [Laboratoire d' Electronique et de Physique des Systemes Instrumentaux, Universite Luis Pasteur, Strasbourg (France); Centre National de la Recherce Scientifique/IN2P3 - Paris (France)] (and others)

    2006-05-01

    The SUCIMA collaboration has been developing instruments and methods for real-time, high granularity imaging of extended electron sources. In particular, dosimetry of intravascular brachytherapy {beta} sources has been intensively studied, together with monitoring of hadrontherapy beams by imaging of secondary electrons emitted by a non-disruptive target. The paper reports the latest results on absolute dosimetry with a large-area silicon strip detectors and on beam monitoring with a hybrid pad sensor.

  11. ATP6V1H Deficiency Impairs Bone Development through Activation of MMP9 and MMP13

    Science.gov (United States)

    Zhao, Gexin; Yokoyama, Tadafumi; Huang, Yan; Bishop, Kevin; Maduro, Valerie; Accardi, John; Toro, Camilo; Boerkoel, Cornelius F.; Gahl, William A.; Duan, Xiaohong; Malicdan, May Christine V.; Lin, Shuo

    2017-01-01

    ATP6V1H is a component of a large protein complex with vacuolar ATPase (V-ATPase) activity. We identified two generations of individuals in which short stature and osteoporosis co-segregated with a mutation in ATP6V1H. Since V-ATPases are highly conserved between human and zebrafish, we generated loss-of-function mutants in atp6v1h in zebrafish through CRISPR/Cas9-mediated gene knockout. Homozygous mutant atp6v1h zebrafish exhibited a severe reduction in the number of mature calcified bone cells and a dramatic increase in the expression of mmp9 and mmp13. Heterozygous adults showed curved vertebra that lack calcified centrum structure and reduced bone mass and density. Treatment of mutant embryos with small molecule inhibitors of MMP9 and MMP13 significantly restored bone mass in the atp6v1h mutants. These studies have uncovered a new, ATP6V1H-mediated pathway that regulates bone formation, and defines a new mechanism of disease that leads to bone loss. We propose that MMP9/MMP13 could be therapeutic targets for patients with this rare genetic disease. PMID:28158191

  12. Effects of Etch-and-Rinse and Self-etch Adhesives on Dentin MMP-2 and MMP-9

    Science.gov (United States)

    Mazzoni, A.; Scaffa, P.; Carrilho, M.; Tjäderhane, L.; Di Lenarda, R.; Polimeni, A.; Tezvergil-Mutluay, A.; Tay, F.R.; Pashley, D.H.; Breschi, L.

    2013-01-01

    Auto-degradation of collagen matrices occurs within hybrid layers created by contemporary dentin bonding systems, by the slow action of host-derived matrix metalloproteinases (MMPs). This study tested the null hypothesis that there are no differences in the activities of MMP-2 and -9 after treatment with different etch-and-rinse or self-etch adhesives. Tested adhesives were: Adper Scotchbond 1XT (3M ESPE), PQ1 (Ultradent), Peak LC (Ultradent), Optibond Solo Plus (Kerr), Prime&Bond NT (Dentsply) (all 2-step etch-and-rinse adhesives), and Adper Easy Bond (3M ESPE), Tri-S (Kuraray), and Xeno-V (Dentsply) (1-step self-etch adhesives). MMP-2 and -9 activities were quantified in adhesive-treated dentin powder by means of an activity assay and gelatin zymography. MMP-2 and MMP-9 activities were found after treatment with all of the simplified etch-and-rinse and self-etch adhesives; however, the activation was adhesive-dependent. It is concluded that all two-step etch-and-rinse and the one-step self-etch adhesives tested can activate endogenous MMP-2 and MMP-9 in human dentin. These results support the role of endogenous MMPs in the degradation of hybrid layers created by these adhesives. PMID:23128110

  13. Localization of Auricular Projection Area of the Liver and Its Use in the Monitoring of Viral Hepatitis

    Institute of Scientific and Technical Information of China (English)

    Jan Z. Szopinski; Xiao Hong Teng; Georg P. Lochner; Tomasz Macura; Iwona Karcz-Socha; Anna Kasprzyk-Minkner; Krzysztof Kielan; Barbara Krupa-Jezierska; Dariusz J. Nasiek; Piotr Warakomski

    2006-01-01

    Background:Localization of auricular projection area of the liver and evaluation of its usefulness in the monitoring of viral hepatitis. Design, Patients and Setting: Comparative study of the degree of electrical rectification measured at various spots in the auricular concha region, in 19 inpatients with hepatitis B and 15 clinically healthy volunteers, at the Department of Infectious Diseases, Provincial Teaching Hospital,Tychy, Poland. Intervention: Evaluation of electrical rectification at various spots on the auricular concha using a "rectification ratio" that quantifies the degree of rectification (normal range:0-60%). Main outcome measure: The location of the skin area where a statistically significant difference existed between the rectification ratios was observed in patients (82±12% at the time of the 'peak period') versus controls (42±8%). Results: A location was identified on the ear auricle where the electrical rectification phenomenon demonstrated a dependence on the presence of hepatitis. Conclusions: Liver projection area exists on the ear auricle which is located within the region of cymba conchae, next to anthelix and the cavity of concha. The existence of viral hepatitis causes this skin area to show a higher degree of electrical rectification once the skin resistance 'breakthrough effect' has been induced. Evaluation of the rectification phenomenon of the liver projection area provides a method of non-invasive monitoring of viral hepatitis.

  14. Continuing pollution from the Rum Jungle U-Cu project: A critical evaluation of environmental monitoring and rehabilitation

    Energy Technology Data Exchange (ETDEWEB)

    Mudd, Gavin M., E-mail: Gavin.Mudd@eng.monash.edu.a [Environmental Engineering, Dept of Civil Engineering, Monash University, Clayton, VIC 3800 (Australia); Patterson, James [Environmental Engineering Consultant, Sydney, NSW (Australia)

    2010-05-15

    The former Rum Jungle uranium-copper project, Australia, is an internationally important case study on environmental pollution from and rehabilitation of mining. The Rum Jungle mining project is briefly reviewed, followed by a critical evaluation of monitoring data and pollution loads prior to and after rehabilitation - leading to the conclusion that rehabilitation has clearly failed the test of time after just two decades. The most critical findings are the need to understand pollution cycles holistically, and designing monitoring regimes to match, explicit inclusion of radiological criteria (lacking in original planning), and finally the need to set targets based on environmental criteria. Two examples include polluted groundwater which was excluded from rehabilitation and the poor design, construction and/or performance of engineered soil covers - both leading to increasing acid drainage impacts on the Finniss River. The critical review therefore presents a valuable case study of the environmental performance of uranium mine site rehabilitation. - The Rum Jungle U-Cu project underwent extensive rehabilitation in the 1980's, however, it remains a major cause of pollution to the Finniss River.

  15. Mid-Columbia - Mapping of Invasive Plants and Monitoring of Efficacy and Impacts in Support of Invasive Control and Rehabilitation Projects 2015

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The proposed project will be to hire and train a volunteer invasives mapping and monitoring crew for two primary purposes. The first will be to locate and map...

  16. Hanford Reach/Columbia - Mapping of Invasive Plants and Monitoring of Efficacy and Impacts in Support of Invasive Control and Rehabilitation Projects

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The proposed project will hire and train an invasives mapping and monitoring crew for two primary purposes. The first will be to locate and map populations of...

  17. Matrix Metalloproteinase-2 (MMP-2) Gene Deletion Enhances MMP-9 Activity, Impairs PARP-1 Degradation, and Exacerbates Hepatic Ischemia and Reperfusion Injury in Mice.

    Science.gov (United States)

    Kato, Hiroyuki; Duarte, Sergio; Liu, Daniel; Busuttil, Ronald W; Coito, Ana J

    2015-01-01

    Hepatic ischemia and reperfusion injury (IRI) is an inflammatory condition and a significant cause of morbidity and mortality after surgery. Matrix metalloproteinases (MMPs) have been widely implicated in the pathogenesis of inflammatory diseases. Among the different MMPs, gelatinases (MMP-2 and MMP-9) are within the most prominent MMPs detected during liver IRI. While the role of MMP-9 in liver damage has been fairly documented, direct evidence of the role for MMP-2 activity in hepatic IRI remains to be established. Due to the lack of suitable inhibitors to target individual MMPs in vivo, gene manipulation is as an essential tool to assess MMP direct contribution to liver injury. Hence, we used MMP-2-/- deficient mice and MMP-2+/+ wild-type littermates to examine the function of MMP-2 activity in hepatic IRI. MMP-2 expression was detected along the sinusoids of wild-type livers before and after surgery and in a small population of leukocytes post-IRI. Compared to MMP-2+/+ mice, MMP-2 null (MMP-2-/-) mice showed exacerbated liver damage at 6, 24, and 48 hours post-reperfusion, which was fatal in some cases. MMP-2 deficiency resulted in upregulation of MMP-9 activity, spontaneous leukocyte infiltration in naïve livers, and amplified MMP-9-dependent transmigration of leukocytes in vitro and after hepatic IRI. Moreover, complete loss of MMP-2 activity impaired the degradation of poly (ADP-ribose) polymerase (PARP-1) in extensively damaged livers post-reperfusion. However, the administration of a PARP-1 inhibitor to MMP-2 null mice restored liver preservation to almost comparable levels of MMP-2+/+ mice post-IRI. Deficient PARP-1 degradation in MMP-2-null sinusoidal endothelial cells correlated with their increased cytotoxicity, evaluated by the measurement of LDH efflux in the medium. In conclusion, our results show for the first time that MMP-2 gene deletion exacerbates liver IRI. Moreover, they offer new insights into the MMP-2 modulation of inflammatory responses

  18. Spring Chinook Salmon Interactions Indices and Residual/Precocial Monitoring in the Upper Yakima Basin; Yakima/Klickitat Fisheries Project Monitoring and Evaluation, 2001-2002 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Pearsons, Todd N.; James, Brenda B.; Johnson, Christopher L. (Washington Department of Fish and Wildlife, Olympia, WA)

    2003-05-01

    . 1997). Monitoring ecological interactions will be accomplished using interactions indices. Interactions indices will be used to index the availability of prey and competition for food and space. The tasks described below represent various subject areas of juvenile spring chinook salmon monitoring but are treated together because they can be accomplished using similar methods and are therefore more cost efficient than if treated separately. Three areas of investigation we pursued in this work were: (1) strong interactor monitoring (competition index and prey index), (2) carrying capacity monitoring (microhabitat monitoring); (3) residual and precocial salmon monitoring (abundance). This report is organized into three chapters to represent these three areas of investigation. Data were collected during the summer and fall, 2002 in index sections of the upper Yakima Basin (Figure 1). Hatchery reared spring chinook salmon were first released during the spring of 1999. The monitoring plan for the Yakima/Klickitat Fisheries Project calls for the continued monitoring of the variables covered in this report. All findings in this report should be considered preliminary and subject to further revision as more data and analytical results become available.

  19. In vitro modulation of MMP-2 and MMP-9 in human cervical and ovarian cancer cell lines by cytokines, inducers and inhibitors.

    Science.gov (United States)

    Roomi, M W; Monterrey, J C; Kalinovsky, T; Rath, M; Niedzwiecki, A

    2010-03-01

    Matrix metalloproteinases (MMPs) secreted by cervical and ovarian cancer, especially MMP-2 and MMP-9, play crucial roles in tumor invasion and metastasis. We examined the effect of cytokines, mitogens, inducers and inhibitors on MMP-2 and MMP-9 expression in cervical and ovarian cancer cell lines. Human cervical (HeLa and DoTc2-4510) and ovarian (SK-OV-3) cell lines were cultured in appropriate media. At near confluence, the cells were washed with PBS and incubated in serum-free medium with various concentrations of several cytokines, mitogens and inhibitors. After 24 h the media were removed and analyzed for MMP-2 and MMP-9 by gelatinase zymography and quantitated by densitometry. HeLa and SK-OV-3 cell lines expressed MMP-2 whereas DoTc2-4510 cells expressed MMP-9. Treatment of cervical cancer cell lines (HeLa and DoTc2-4510) with PMA had no effect on MMP-2 expression and a moderate stimulatory effect in ovarian cancer cell line SK-OV-3. MMP-9 was stimulated by phorbol 12-myristate 13-acetate in HeLa cells and enhanced in DoTc2-4510. Tumor necrosis factor-alpha and interleukin-1beta, had slight inhibitory effect on HeLa cell expression of MMP-2 while lipopolysaccharide stimulated MMP-2 in HeLa cells. Doxycycline, epigallocatechin gallate, a nutrient mixture, actinomycin-D, cyclohexamide, retinoic acid and dexamethasone inhibited MMP-2 in HeLa and SK-OV-3 cell lines and inhibited MMP-9 in DoTc2-4510. Our results show that cytokines, mitogens, inducers and inhibitors have an up or down regulatory effect on MMP-2 and MMP-9 expression in ovarian and cervical cancer cell lines, suggesting these agents may be effective strategies to treat these cancers.

  20. Air Sensor Kit Performance Testing and Pollutant Mapping Supports Community Air Monitoring Project

    Science.gov (United States)

    EPA is collaborating on a research project with the South Coast Air Quality Management District in Diamond Bar, Calif. to gain an enhanced understanding of fine particulate matter (PM2.5) and ozone concentrations across the study area.