WorldWideScience

Sample records for monitor units mus

  1. Nova Mus 2008 = QY Mus

    Science.gov (United States)

    Templeton, Matthew R.

    2008-10-01

    Nova Mus 2008 = QY Mus was discovered by William Liller, Vina del Mar, Chile, on 2008 September 28.998 UT at magnitude 8.6 (Tech Pan film + orange filter). The position is RA = 13h 16m 36.44s , Dec = -67d 36m 47.8s (from P. Nelson). This object was announced as a nova in IAU Circular 8990 (Daniel W.E. Green, editor). The nova classification was determined using low-resolution spectra by W. Liller indicating the presence of broad H-alpha lines at least 2300 angstroms wide. Several observers confirmed the nova and provided photometry. The position above was provided by Peter Nelson (Ellinbank, Vic., Aus.), and is averaged from four separate exposures (rms error approx. 0.4 arcseconds). The GCVS team have formally designated Nova Mus 2008 as QY MUS. Observations should be reported to the AAVSO International Database as QY MUS.

  2. A monitor unit "odometer" for measuring linac workload.

    Science.gov (United States)

    Evans, M D; Larkin, J J; Léger, P; Podgorsak, E B

    2001-12-01

    The annual linac workload is often required by regulatory agencies to assess compliance with license conditions. Summation of the monitor units produced by the machine is generally used for this purpose. Various methods of estimating this value have inherent inaccuracies. We have built an integrating Monitor Unit "odometer" that is able to automatically accumulate all MUs delivered by the linac and segregate the total by mode (photon or electron) and energy. The device has been used to record clinical linac MU workloads for 10 months, and was installed in a new dual-energy linac during the acceptance and commissioning process.

  3. Independent calculation of monitor units for VMAT and SPORT

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Xin; Bush, Karl; Ding, Aiping; Xing, Lei, E-mail: lei@stanford.edu [Department of Radiation Oncology, Stanford University, Stanford, California 94305 (United States)

    2015-02-15

    Purpose: Dose and monitor units (MUs) represent two important facets of a radiation therapy treatment. In current practice, verification of a treatment plan is commonly done in dose domain, in which a phantom measurement or forward dose calculation is performed to examine the dosimetric accuracy and the MU settings of a given treatment plan. While it is desirable to verify directly the MU settings, a computational framework for obtaining the MU values from a known dose distribution has yet to be developed. This work presents a strategy to calculate independently the MUs from a given dose distribution of volumetric modulated arc therapy (VMAT) and station parameter optimized radiation therapy (SPORT). Methods: The dose at a point can be expressed as a sum of contributions from all the station points (or control points). This relationship forms the basis of the proposed MU verification technique. To proceed, the authors first obtain the matrix elements which characterize the dosimetric contribution of the involved station points by computing the doses at a series of voxels, typically on the prescription surface of the VMAT/SPORT treatment plan, with unit MU setting for all the station points. An in-house Monte Carlo (MC) software is used for the dose matrix calculation. The MUs of the station points are then derived by minimizing the least-squares difference between doses computed by the treatment planning system (TPS) and that of the MC for the selected set of voxels on the prescription surface. The technique is applied to 16 clinical cases with a variety of energies, disease sites, and TPS dose calculation algorithms. Results: For all plans except the lung cases with large tissue density inhomogeneity, the independently computed MUs agree with that of TPS to within 2.7% for all the station points. In the dose domain, no significant difference between the MC and Eclipse Anisotropic Analytical Algorithm (AAA) dose distribution is found in terms of isodose contours

  4. Effect of Acuros XB algorithm on monitor units for stereotactic body radiotherapy planning of lung cancer.

    Science.gov (United States)

    Khan, Rao F; Villarreal-Barajas, Eduardo; Lau, Harold; Liu, Hong-Wei

    2014-01-01

    Stereotactic body radiotherapy (SBRT) is a curative regimen that uses hypofractionated radiation-absorbed dose to achieve a high degree of local control in early stage non-small cell lung cancer (NSCLC). In the presence of heterogeneities, the dose calculation for the lungs becomes challenging. We have evaluated the dosimetric effect of the recently introduced advanced dose-calculation algorithm, Acuros XB (AXB), for SBRT of NSCLC. A total of 97 patients with early-stage lung cancer who underwent SBRT at our cancer center during last 4 years were included. Initial clinical plans were created in Aria Eclipse version 8.9 or prior, using 6 to 10 fields with 6-MV beams, and dose was calculated using the anisotropic analytic algorithm (AAA) as implemented in Eclipse treatment planning system. The clinical plans were recalculated in Aria Eclipse 11.0.21 using both AAA and AXB algorithms. Both sets of plans were normalized to the same prescription point at the center of mass of the target. A secondary monitor unit (MU) calculation was performed using commercial program RadCalc for all of the fields. For the planning target volumes ranging from 19 to 375cm(3), a comparison of MUs was performed for both set of algorithms on field and plan basis. In total, variation of MUs for 677 treatment fields was investigated in terms of equivalent depth and the equivalent square of the field. Overall, MUs required by AXB to deliver the prescribed dose are on an average 2% higher than AAA. Using a 2-tailed paired t-test, the MUs from the 2 algorithms were found to be significantly different (p algorithms.

  5. Intelligent monitoring system for intensive care units.

    Science.gov (United States)

    Nouira, Kaouther; Trabelsi, Abdelwahed

    2012-08-01

    We address in the present paper a medical monitoring system designed as a multi-agent based approach. Our system includes mainly numerous agents that act as correlated multi-agent sub-systems at the three layers of the whole monitoring infrastructure, to avoid non informative alarms and send effective alarms at time. The intelligence in the proposed monitoring system is provided by the use of time series technology. In fact, the capability of continuous learning of time series from the physiological variables allows the design of a system that monitors patients in real-time. Such system is a contrast to the classical threshold-based monitoring system actually present in the Intensive Care Units (ICUs) which causes a huge number of irrelevant alarms.

  6. Identification of management units using population genetic data

    NARCIS (Netherlands)

    Palsboll, Per J.; Berube, Martine; Allendorf, Fred W.

    2007-01-01

    The identification of management units (MUs) is central to the management of natural populations and is crucial for monitoring the effects of human activity upon species abundance. Here, we propose that the identification of MUs from population genetic data should be based upon the amount of genetic

  7. Routine polysomnography in an epilepsy monitoring unit.

    Science.gov (United States)

    Phillips, Matthew C L; Costello, Craig A; White, Elise J; Smit, Michelle; Carino, John; Strawhorn, Andrew; Jackson, Brianna; Kwan, Patrick; French, Christopher R; Yerra, S Raju; Tan, K Meng; O'Brien, Terence J; Goldin, Jeremy

    2013-08-01

    Up to 13% of patients with epilepsy have moderate or severe sleep-disordered breathing, in particular obstructive sleep apnea (OSA), a disorder associated with reduced quality of life, worsened seizure control, and increased cardiovascular morbidity and mortality. Combining video-EEG monitoring with polysomnography (VPSG) provides the opportunity to diagnose clinically significant OSA as well as relate the occurrence of seizures and the epilepsy diagnosis to the presence and severity of sleep-disordered breathing. We have established routine VPSG in our inpatient video-EEG monitoring unit and present our findings in 87 patients. Clinically significant sleep-disordered breathing was diagnosed in 19 of 87 (22%) patients. Patients with psychogenic non-epileptic seizures (PNES) had poorer sleep quality compared to patients with epilepsy and those with neither diagnosis, whereas the prevalence of clinically significant sleep-disordered breathing in patients with PNES (29%) did not differ significantly compared to patients with epilepsy (21%) and those with neither diagnosis (22%). The differences in sleep quality are not explained by differences in body mass index (BMI) or anti-epileptic drug (AED) effects.

  8. La Deuotio de Decio Mus

    OpenAIRE

    2011-01-01

    En la presente comunicación pretendemos abordar el tema de la pervivencia de la Historia Antigua como fuente iconográfica para el arte europeo de la Edad Moderna (el siglo XVII en nuestro caso). En una primera parte, analizaremos el ritual de la deuotio, contextualizándolo dentro de la religión romana republicana. A partir de las fuentes literarias prestaremos especial atención al estudio de la deuotio de Decio Mus. El siguiente paso será poner lo anterior en relación con Rubens y su ciclo de...

  9. La Deuotio de Decio Mus

    Directory of Open Access Journals (Sweden)

    José Manuel Aldea Celada

    2011-06-01

    Full Text Available En la presente comunicación pretendemos abordar el tema de la pervivencia de la Historia Antigua como fuente iconográfica para el arte europeo de la Edad Moderna (el siglo XVII en nuestro caso. En una primera parte, analizaremos el ritual de la deuotio, contextualizándolo dentro de la religión romana republicana. A partir de las fuentes literarias prestaremos especial atención al estudio de la deuotio de Decio Mus. El siguiente paso será poner lo anterior en relación con Rubens y su ciclo dedicado a la deuotio de Decio Mus, intentando explicar qué motivo la elección del tema (comitente y destino de la obra, cuál de las fuentes fue la que inspiró a Rubens y qué elementos iconográficos fueron empleados para dar forma al ritual en las diferente escenas que componen el ciclo.

  10. Initial Survey Instructions for management unit water monitoring : level

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Initial survey instructions for 1.08 management unit water monitoring (level) survey on Fish Springs National Wildlife Refuge. This survey is conducted weekly and is...

  11. Jaguar surveying and monitoring in the United States

    Science.gov (United States)

    Culver, Melanie

    2016-06-10

    Because of the jaguar’s (Panthera onca) endangered status under the Endangered Species Act (ESA) of 1973 throughout its range (from Arizona in the north to Argentina in the south), jaguar individuals and populations are monitored to varying degrees throughout their range. Knowledge gained from monitoring jaguars is helpful for wildlife managers who are responsible for conserving this species. The University of Arizona (UA) has conducted a multiyear surveying and monitoring effort for jaguars and ocelots in southern Arizona and New Mexico. The purpose of this work was to establish an effective surveying and monitoring system for jaguars along the United States-Mexico border. Surveying and monitoring in this study focused on the United States side of the border, but the methods could also be used in Mexico. The intent was to develop and implement a surveying and monitoring system that would provide the greatest probability of recording jaguar presence in, and passage through, the border area.

  12. Analyzing the characteristics of 6 MV photon beam at low monitor unit settings

    Directory of Open Access Journals (Sweden)

    L Nithya

    2016-01-01

    Full Text Available Analyzing the characteristics of a low monitor unit (MU setting is essential, particularly for intensity-modulated techniques. Intensity modulation can be achieved through intensity-modulated radiotherapy (IMRT or volumetric-modulated arc therapy (VMAT. There is possibility for low MUs in the segments of IMRT and VMAT plans. The minimum MU/segment must be set by the physicist in the treatment planning system at the time of commissioning. In this study, the characteristics such as dose linearity, stability, flatness, and symmetry of 6 MV photon beam of a Synergy linear accelerator at low MU settings were investigated for different dose rates. The measurements were performed for Synergy linear accelerator using a slab phantom with a FC65-G chamber and Profiler 2. The MU linearity was studied for 1–100 MU using a field size of 10 cm ×10 cm. The linearity error for 1 MU was 4.2%. Flatness of the beam was deteriorated in 1 MU condition. The beam stability and symmetry was well within the specification. Using this study, we conclude that the treatment delivered with <3 MU may result in uncertainty in dose delivery. To ensure the correct dose delivery with less uncertainty, it is recommended to use ≥3 MU as the minimum MU per segment in IMRT and VMAT plans.

  13. Total monitor units influence on plan quality parameters in volumetric modulated arc therapy for breast case.

    Science.gov (United States)

    Mancosu, P; Reggiori, G; Alongi, F; Cozzi, L; Fogliata, A; Lobefalo, F; Navarria, P; Stravato, A; Tomatis, S; Scorsetti, M

    2014-05-01

    To investigate the correlation between total monitor units (MU), dosimetric findings, and pre-treatment quality assurance for volumetric modulated arc therapy (VMAT) by RapidArc (RA). Ten patients with breast cancer were considered. Dose prescriptions were: 48 Gy and 40.5 Gy in 15 fractions to, respectively, PTV(Boost) and PTVWholeBreast. A reference plan was optimized and four more plans using the "MU Objective", a tool for total MU controlling, were prepared imposing ± 20 and ± 50% total MU for inducing different complexities. Plan objectives were: D95% > 95% for both PTVs, and D2% Plans were evaluated in terms of technical parameters, dosimetric plan objectives findings and pre-treatment quality assurance (QA). Concerning PTVs, there were no significant differences for target coverage (D95%); mean doses for ipsilateral lung and controlateral breast, and V18 Gy for heart decreased with MUs increasing, reaching a plateau with reference plan. Body volume receiving low dose (V5-10 Gy) was minimized for reference plans. All plans had GAI (3 mm, 3%) > 95%. The data suggest that the best plan is the reference one, where the "MU Objective" tool was not used during optimisation. Nevertheless, it is advisable to use the "MU Objective" tool for re-planning when low GAI is found to increase its value. In this case, attention should be paid to OARs dose limits, since their values may be increased. Copyright © 2013 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  14. Monitoring hearing loss at United Airlines.

    Science.gov (United States)

    Weaver, J H; Harper, R

    1981-08-01

    The airlines are a highly diversified industry. Their major concerns are in the safe transportation of passengers and cargo with on time arrival and departure of its aircraft at various locations throughout the world. The challenge the airlines face is in the development and administration of an effective hearing conservation program that will produce valid audiometry at all of its logistic operations and yet be economically feasible and practical. The methods and techniques used by United Airlines to develop and administer an effective hearing conservation program are presented here. Guidelines employing the OSHA Noise Exposure Standard were incorporated in the program requirements as set forth by the medical department.

  15. Monitoring the injured brain in the intensive care unit.

    Directory of Open Access Journals (Sweden)

    Gupta A

    2002-07-01

    Full Text Available The primary aim of managing patients with acute brain injury in the intensive care unit is to minimise secondary injury by maintaining cerebral perfusion and oxygenation. The mechanisms of secondary injury are frequently triggered by secondary insults, which may be subtle and remain undetected by the usual systemic physiological monitoring. Continuous monitoring of the central nervous system in the intensive care unit can serve two functions. Firstly it will help early detection of these secondary cerebral insults so that appropriate interventions can be instituted. Secondly, it can help to monitor therapeutic interventions and provide online feedback. This review focuses on the monitoring of intracranial pressure, blood flow to the brain (Transcranial Doppler, cerebral oxygenation using the methods of jugular bulb oximetry, near infrared spectroscopy and implantable sensors, and the monitoring of function using electrophysiological techniques.

  16. LINE-1 repetitive DNA probes for species-specific cloning from Mus spretus and Mus domesticus genomes.

    Science.gov (United States)

    Rikke, B A; Hardies, S C

    1991-12-01

    Mus domesticus and Mus spretus mice are closely related subspecies. For genetic investigations involving hybrid mice, we have developed a set of species-specific oligonucleotide probes based on the detection of LINE-1 sequence differences. LINE-1 is a repetitive DNA family whose many members are interspersed among the genes. In this study, library screening experiments were used to fully characterize the species specificity of four M. domesticus LINE-1 probes and three M. spretus LINE-1 probes. It was found that the nucleotide differences detected by the probes define large, species-specific subfamilies. We show that collaborative use of such probes can be employed to selectively detect thousands of species-specific library clones. Consequently, these probes could be exploited to monitor and access almost any given species-specific region of interest within hybrid genomes.

  17. The extratemporal lobe epilepsies in the epilepsy monitoring unit

    Science.gov (United States)

    Dash, Deepa; Tripathi, Manjari

    2014-01-01

    Extratemporal lobe epilepsies (ETLE) are characterized by the epileptogenic foci outside the temporal lobe. They have a wide spectrum of semiological presentation depending upon the site of origin. They can arise from frontal, parietal, occipital lobes and from hypothalamic hamartoma. We discuss in this review the semiology of different types of ETLE encountered in the epilepsy monitoring unit. PMID:24791090

  18. Tracking motor units longitudinally across experimental sessions with high‐density surface electromyography

    Science.gov (United States)

    Martinez‐Valdes, E.; Negro, F.; Laine, C. M.; Falla, D.; Mayer, F.

    2017-01-01

    Key points Classic motor unit (MU) recording and analysis methods do not allow the same MUs to be tracked across different experimental sessions, and therefore, there is limited experimental evidence on the adjustments in MU properties following training or during the progression of neuromuscular disorders.We propose a new processing method to track the same MUs across experimental sessions (separated by weeks) by using high‐density surface electromyography.The application of the proposed method in two experiments showed that individual MUs can be identified reliably in measurements separated by weeks and that changes in properties of the tracked MUs across experimental sessions can be identified with high sensitivity.These results indicate that the behaviour and properties of the same MUs can be monitored across multiple testing sessions.The proposed method opens new possibilities in the understanding of adjustments in motor unit properties due to training interventions or the progression of pathologies. Abstract A new method is proposed for tracking individual motor units (MUs) across multiple experimental sessions on different days. The technique is based on a novel decomposition approach for high‐density surface electromyography and was tested with two experimental studies for reliability and sensitivity. Experiment I (reliability): ten participants performed isometric knee extensions at 10, 30, 50 and 70% of their maximum voluntary contraction (MVC) force in three sessions, each separated by 1 week. Experiment II (sensitivity): seven participants performed 2 weeks of endurance training (cycling) and were tested pre–post intervention during isometric knee extensions at 10 and 30% MVC. The reliability (Experiment I) and sensitivity (Experiment II) of the measured MU properties were compared for the MUs tracked across sessions, with respect to all MUs identified in each session. In Experiment I, on average 38.3% and 40.1% of the identified MUs could be

  19. Independent verification of monitor unit calculation for radiation treatment planning system.

    Science.gov (United States)

    Chen, Li; Chen, Li-Xin; Huang, Shao-Min; Sun, Wen-Zhao; Sun, Hong-Qiang; Deng, Xiao-Wu

    2010-02-01

    To ensure the accuracy of dose calculation for radiation treatment plans is an important part of quality assurance (QA) procedures for radiotherapy. This study evaluated the Monitor Units (MU) calculation accuracy of a third-party QA software and a 3-dimensional treatment planning system (3D TPS), to investigate the feasibility and reliability of independent verification for radiation treatment planning. Test plans in a homogenous phantom were designed with 3-D TPS, according to the International Atomic Energy Agency (IAEA) Technical Report No. 430, including open, blocked, wedge, and multileaf collimator (MLC) fields. Test plans were delivered and measured in the phantom. The delivered doses were input to the QA software and the independent calculated MUs were compared with delivery. All test plans were verified with independent calculation and phantom measurements separately, and the differences of the two kinds of verification were then compared. The deviation of the independent calculation to the measurements was (0.1 +/- 0.9)%, the biggest difference fell onto the plans that used block and wedge fields (2.0%). The mean MU difference between the TPS and the QA software was (0.6 +/- 1.0)%, ranging from -0.8% to 2.8%. The deviation in dose of the TPS calculation compared to the measurements was (-0.2 +/- 1.7)%, ranging from -3.9% to 2.9%. MU accuracy of the third-party QA software is clinically acceptable. Similar results were achieved with the independent calculations and the phantom measurements for all test plans. The tested independent calculation software can be used as an efficient tool for TPS plan verification.

  20. A high arctic experience of uniting research and monitoring

    Science.gov (United States)

    Schmidt, Niels Martin; Christensen, Torben R.; Roslin, Tomas

    2017-07-01

    Monitoring is science keeping our thumb on the pulse of the environment to detect any changes of concern for societies. Basic science is the question-driven search for fundamental processes and mechanisms. Given the firm root of monitoring in human interests and needs, basic sciences have often been regarded as scientifically "purer"—particularly within university-based research communities. We argue that the dichotomy between "research" and "monitoring" is an artificial one, and that this artificial split clouds the definition of scientific goals and leads to suboptimal use of resources. We claim that the synergy between the two scientific approaches is well distilled by science conducted under extreme logistic constraints, when scientists are forced to take full advantage of both the data and the infrastructure available. In evidence of this view, we present our experiences from two decades of uniting research and monitoring at the remote research facility Zackenberg in High Arctic Greenland. For this site, we show how the combination of insights from monitoring with the mechanistic understanding obtained from basic research has yielded the most complete understanding of the system—to the benefit of all, and as an example to follow. We therefore urge scientists from across the continuum from monitoring to research to come together, to disregard old division lines, and to work together to expose a comprehensive picture of ecosystem change and its consequences.

  1. Prescription drug monitoring programs in the United States of America

    Science.gov (United States)

    Félix, Sausan El Burai; Mack, Karin

    2015-01-01

    SYNOPSIS Since the late 1990s, the number of opioid analgesic overdose deaths has quadrupled in the United States of America (from 4 030 deaths in 1999 to 16 651 in 2010). The objectives of this article are to provide an overview of the problem of prescription drug overdose in the United States and to discuss actions that could help reduce the problem, with particular attention to the characteristics of prescription drug monitoring programs (PDMPs). These programs consist of state-level databases that monitor controlled substances. The information compiled in the databases is at the disposal of authorized persons (e.g., physicians, pharmacists, and other health-care providers) and may be used only for professional purposes. Suppliers can use such information to prevent interaction with other drugs or therapeutic duplication, or to identify drug-search behavior. Law enforcement agencies can use these programs to identify improper drug prescription or dispensing patterns, or drug diversion. PMID:25563153

  2. Monitor unit calculations for breast or chest wall treatments.

    Science.gov (United States)

    Cheng, P C; Ames, T; Howard-Ames, T; Kohut, H; Heleba, V; Krishnamoorthy, J

    1989-01-01

    Tangential breast fields always "flash" beyond the surface of the patient. Since the portion of the beam that is in air does not contribute scatter, external beam treatment planning computers that utilize stored beam data can lead to dose errors of up to 10%. These errors can be reduced by using an irregular field calculation program to adjust the monitor units to account for the loss of scatter.

  3. Hemodynamic monitoring in the intensive care unit: a Brazilian perspective

    Science.gov (United States)

    Dias, Fernando Suparregui; Rezende, Ederlon Alves de Carvalho; Mendes, Ciro Leite; Silva Jr., João Manoel; Sanches, Joel Lyra

    2014-01-01

    Objective In Brazil, there are no data on the preferences of intensivists regarding hemodynamic monitoring methods. The present study aimed to identify the methods used by national intensivists, the hemodynamic variables they consider important, the regional differences, the reasons for choosing a particular method, and the use of protocols and continued training. Methods National intensivists were invited to answer an electronic questionnaire during three intensive care events and later, through the Associação de Medicina Intensiva Brasileira portal, between March and October 2009. Demographic data and aspects related to the respondent preferences regarding hemodynamic monitoring were researched. Results In total, 211 professionals answered the questionnaire. Private hospitals showed higher availability of resources for hemodynamic monitoring than did public institutions. The pulmonary artery catheter was considered the most trusted by 56.9% of the respondents, followed by echocardiograms, at 22.3%. Cardiac output was considered the most important variable. Other variables also considered relevant were mixed/central venous oxygen saturation, pulmonary artery occlusion pressure, and right ventricular end-diastolic volume. Echocardiography was the most used method (64.5%), followed by pulmonary artery catheter (49.3%). Only half of respondents used treatment protocols, and 25% worked in continuing education programs in hemodynamic monitoring. Conclusion Hemodynamic monitoring has a greater availability in intensive care units of private institutions in Brazil. Echocardiography was the most used monitoring method, but the pulmonary artery catheter remains the most reliable. The implementation of treatment protocols and continuing education programs in hemodynamic monitoring in Brazil is still insufficient. PMID:25607264

  4. Brainstem Monitoring in the Neurocritical Care Unit: A Rationale for Real-Time, Automated Neurophysiological Monitoring.

    Science.gov (United States)

    Stone, James L; Bailes, Julian E; Hassan, Ahmed N; Sindelar, Brian; Patel, Vimal; Fino, John

    2017-02-01

    Patients with severe traumatic brain injury or large intracranial space-occupying lesions (spontaneous cerebral hemorrhage, infarction, or tumor) commonly present to the neurocritical care unit with an altered mental status. Many experience progressive stupor and coma from mass effects and transtentorial brain herniation compromising the ascending arousal (reticular activating) system. Yet, little progress has been made in the practicality of bedside, noninvasive, real-time, automated, neurophysiological brainstem, or cerebral hemispheric monitoring. In this critical review, we discuss the ascending arousal system, brain herniation, and shortcomings of our current management including the neurological exam, intracranial pressure monitoring, and neuroimaging. We present a rationale for the development of nurse-friendly-continuous, automated, and alarmed-evoked potential monitoring, based upon the clinical and experimental literature, advances in the prognostication of cerebral anoxia, and intraoperative neurophysiological monitoring.

  5. Determination of monitor unit check tolerances based on a comparison with measurement and treatment planning system data

    Energy Technology Data Exchange (ETDEWEB)

    Curtis, Helen [Medical Physics Department, The James Cook University Hospital, Middlesbrough (United Kingdom); Richmond, Neil, E-mail: neil.richmond@stees.nhs.uk [Medical Physics Department, The James Cook University Hospital, Middlesbrough (United Kingdom); Burke, Kevin; Walker, Chris [Medical Physics Department, The James Cook University Hospital, Middlesbrough (United Kingdom)

    2013-04-01

    ABSTRACT: This work describes the experimental validation of treatment planning system monitor unit (MU) calculations against measurement for a range of scenarios. This, together with a comparison of treatment planning system MUs and an independent MU check method, allows the derivation of confidence intervals for the check process. Data were collected for open and 60° motorized wedge fields using an Elekta Synergy linac at 6 and 8 MV using homogeneous and heterogeneous phantoms. Masterplan (Version 4.0) pencil-beam and collapsed cone algorithms were used for the primary MU calculations with full inhomogeneity correction. Results show that both algorithms agree with measurement to acceptable tolerance levels in the majority of the cases studied. The confidence interval for the pencil-beam algorithm MU against an independent check was determined as + 1.6% to −3.4%. This is modified to + 2.3% to −2.5% when data collected with low-density heterogeneities are removed as this algorithm is not used clinically for these cases. The corresponding interval for the collapsed cone algorithm was + 1.2% to −4.3%, indicating that an offset tolerance for the independent check is appropriate. Analysis of clinical conformal treatment plan data generated using the pencil-beam algorithm (1393 beams) returned 93% of beams within the independent check tolerance. Similarly, using the collapsed cone algorithm as the primary MU calculation, 77% (of 1434 beams) were within the confidence interval.

  6. Determination of monitor unit check tolerances based on a comparison with measurement and treatment planning system data.

    Science.gov (United States)

    Curtis, Helen; Richmond, Neil; Burke, Kevin; Walker, Chris

    2013-01-01

    This work describes the experimental validation of treatment planning system monitor unit (MU) calculations against measurement for a range of scenarios. This, together with a comparison of treatment planning system MUs and an independent MU check method, allows the derivation of confidence intervals for the check process. Data were collected for open and 60° motorized wedge fields using an Elekta Synergy linac at 6 and 8MV using homogeneous and heterogeneous phantoms. Masterplan (Version 4.0) pencil-beam and collapsed cone algorithms were used for the primary MU calculations with full inhomogeneity correction. Results show that both algorithms agree with measurement to acceptable tolerance levels in the majority of the cases studied. The confidence interval for the pencil-beam algorithm MU against an independent check was determined as + 1.6% to -3.4%. This is modified to + 2.3% to -2.5% when data collected with low-density heterogeneities are removed as this algorithm is not used clinically for these cases. The corresponding interval for the collapsed cone algorithm was + 1.2% to -4.3%, indicating that an offset tolerance for the independent check is appropriate. Analysis of clinical conformal treatment plan data generated using the pencil-beam algorithm (1393 beams) returned 93% of beams within the independent check tolerance. Similarly, using the collapsed cone algorithm as the primary MU calculation, 77% (of 1434 beams) were within the confidence interval.

  7. Superovulation and in vitro oocyte maturation in three species of mice (Mus musculus, Mus spretus and Mus spicilegus).

    Science.gov (United States)

    Martín-Coello, J; González, R; Crespo, C; Gomendio, M; Roldan, E R S

    2008-10-01

    Mouse oocytes can be obtained via superovulation or using in vitro maturation although several factors, including genetic background, may affect response. Our previous studies have identified various mouse species as models to understand the role of sexual selection on the evolution of sperm traits and function. In order to do comparative studies of sperm-oocyte interaction, we sought reliable methods for oocyte superovulation and in vitro maturation in mature females of three mouse species (genus Mus). When 5 IU pregnant mare's serum gonadotrophin (PMSG) and 5 IU human chorionic gonadotrophin (hCG) were injected 48 h apart, and oocytes collected 14 h post-hCG, good responses were obtained in Mus musculus (18+/-1.3 oocytes/female; mean+/-S.E.M.) and Mus spretus (12+/-0.8), but no ovulation was seen in Mus spicilegus. Changes in PMSG or hCG doses, or longer post-hCG intervals, did not improve results. Use of PMSG/luteinizing hormone (LH) resulted in good responses in M. musculus (19+/-1.2) and M. spretus (12+/-1.1) but not in M. spicilegus (5+/-0.9) with ovulation not increasing with higher LH doses. Follicular puncture 48 h after PMSG followed by in vitro maturation led to a high oocyte yield in the three species (M. musculus, 23+/-0.9; M. spretus, 17+/-1.1; M. spicilegus, 10+/-0.9) with a consistently high maturation rates. In vitro fertilization of both superovulated and in vitro matured oocytes resulted in a high proportion of fertilization (range: 83-87%) in the three species. Thus, in vitro maturation led to high yields in all three species. These results will allow future studies on gamete interaction in these closely related species and the role of sexual selection in gamete compatibility.

  8. SU-E-T-31: Alternative VMAT Technique Reduces Total Monitor Units for Lung SBRT

    Energy Technology Data Exchange (ETDEWEB)

    Happersett, L; Mechalakos, J; Kuo, L; Zhang, P; Rimner, A [Memorial Sloan-Kettering Cancer Center, NY, NY (United States)

    2014-06-01

    Purpose: To investigate an alternative approach to VMAT optimization for hypofractionation lung treatment which increases average aperture opening and results in lower total Monitor Units (MU) without significantly sacrificing plan quality. Methods: Benchmark Volumetric Modulated Arc Therapy (bVMAT) plans were generated for 10 lung Stereotactic Body radiotherapy (SBRT) cases using Eclipse Version 11.0.42 (Varian Medical Systems) without a maximum MU constraint. Prescriptions ranged from 40 to 54Gy in 3 to 5 fractions. AAA dose calculation and PRO fluence based optimization was utilized. Two comparison VMAT plans were generated for each case, one that forced an initial “open” mlc aperture conformal to the tumor as a starting condition (oVMAT) with similar optimization parameters and arc geometries, and one that repeated the bVMAT optimization but added a maximum MU constraint (muVMAT). All plans used two arcs with lengths between 168 to 230 degrees. PTV D 95% and Dmean, lung V20 Gy, chest wall V30 Gy, average aperture opening and MU's were compared. Statistical significance was evaluated using Wilcoxon signed rank test. Results: Average PTV D(95), PTV mean and lung V20Gy over all plans was 99.2 ± 1.7%, 103.3 ± 0.6% and 7.8 ± 2.4% respectively. The average chest wall V30Gy was 61 ± 61 cc and ranged between 0 to 166 cc. There were no significant differences between the three techniques for the dosimetric quantities. MUs were reduced by 11 ±11% (p<0.01) and 25 ± 5% (p<0.01) and the average aperture size was increased by 13.7 ± 14% (p=0.02) and 35.8 ± 10% (p<0.01) with muVMAT and oVMAT, respectively, compared to bVMAT. Conclusion: oVMAT and muVMAT techniques were both able to increase average aperture size and reduce total MU compared to the benchmark VMAT plan, but the magnitude of the changes observed for oVMAT was larger.

  9. Quand le musée soigne

    OpenAIRE

    Marin, Axelle

    2015-01-01

    Après avoir rappelé les fondements historiques de l’art-thérapie, l’auteure relate l’expérience menée au musée d’Art et d’Histoire de Dreux avec la mise en place d’ateliers de psychothérapie à médiation artistique qui s’inscrivent dans le cadre d’une politique volontariste d’ouverture du musée à tous les types de publics et qui s’adressent à des patients de l’hôpital de la ville atteints de maladie névrotiques et psychotiques.

  10. The importance of cardiac monitoring in the epilepsy monitoring unit: a case presentation of ictal asystole.

    Science.gov (United States)

    Agostini, Susan D; Aniles, Ejerzain; Sirven, Joseph; Drazkowski, Joseph F

    2012-09-01

    Ictal asystole may be a potent marker for epilepsy patients at high risk for sudden unexpected death in epilepsy (SUDEP). The use of inpatient long-term video-electroencephalographic (VEEG) monitoring coupled with simultaneous continuous cardiac telemetry is an important tool to detect ictal asystole as well as other significant ictal cardiac arrhythmias. In this paper a case of ictal asystole detected during VEEG is presented. Routine 12-lead EKG was normal upon admission. After antiepileptic medication was tapered, the patient had a typical complex partial seizure with oral automatisms at onset followed by secondary generalization. Ictal onset was noted in left temporal lobe with subsequent spread to the right temporal region. A 20 second period of asystole began just prior to the secondary generalization. During this admission the patient underwent a potentially life-saving pacemaker implantation. The use of cardiac telemetry and baseline EKG are suggested for patients admitted into epilepsy monitoring units as part of the standard epilepsy monitoring protocol.

  11. Evolution of major milk proteins in Mus musculus and Mus spretus mouse species: a genoproteomic analysis

    Directory of Open Access Journals (Sweden)

    Panthier Jean-Jacques

    2011-01-01

    Full Text Available Abstract Background Due to their high level of genotypic and phenotypic variability, Mus spretus strains were introduced in laboratories to investigate the genetic determinism of complex phenotypes including quantitative trait loci. Mus spretus diverged from Mus musculus around 2.5 million years ago and exhibits on average a single nucleotide polymorphism (SNP in every 100 base pairs when compared with any of the classical laboratory strains. A genoproteomic approach was used to assess polymorphism of the major milk proteins between SEG/Pas and C57BL/6J, two inbred strains of mice representative of Mus spretus and Mus musculus species, respectively. Results The milk protein concentration was dramatically reduced in the SEG/Pas strain by comparison with the C57BL/6J strain (34 ± 9 g/L vs. 125 ± 12 g/L, respectively. Nine major proteins were identified in both milks using RP-HPLC, bi-dimensional electrophoresis and MALDI-Tof mass spectrometry. Two caseins (β and αs1 and the whey acidic protein (WAP, showed distinct chromatographic and electrophoresis behaviours. These differences were partly explained by the occurrence of amino acid substitutions and splicing variants revealed by cDNA sequencing. A total of 34 SNPs were identified in the coding and 3'untranslated regions of the SEG/Pas Csn1s1 (11, Csn2 (7 and Wap (8 genes. In addition, a 3 nucleotide deletion leading to the loss of a serine residue at position 93 was found in the SEG/Pas Wap gene. Conclusion SNP frequencies found in three milk protein-encoding genes between Mus spretus and Mus musculus is twice the values previously reported at the whole genome level. However, the protein structure and post-translational modifications seem not to be affected by SNPs characterized in our study. Splicing mechanisms (cryptic splice site usage, exon skipping, error-prone junction sequence, already identified in casein genes from other species, likely explain the existence of multiple αs1-casein

  12. Expanding the genetic code of Mus musculus

    Science.gov (United States)

    Han, Songmi; Yang, Aerin; Lee, Soonjang; Lee, Han-Woong; Park, Chan Bae; Park, Hee-Sung

    2017-01-01

    Here we report the expansion of the genetic code of Mus musculus with various unnatural amino acids including Nɛ-acetyl-lysine. Stable integration of transgenes encoding an engineered Nɛ-acetyl-lysyl-tRNA synthetase (AcKRS)/tRNAPyl pair into the mouse genome enables site-specific incorporation of unnatural amino acids into a target protein in response to the amber codon. We demonstrate temporal and spatial control of protein acetylation in various organs of the transgenic mouse using a recombinant green fluorescent protein (GFPuv) as a model protein. This strategy will provide a powerful tool for systematic in vivo study of cellular proteins in the most commonly used mammalian model organism for human physiology and disease. PMID:28220771

  13. MUS81 promotes common fragile site expression

    DEFF Research Database (Denmark)

    Ying, Songmin; Minocherhomji, Sheroy; Chan, Kok Lung

    2013-01-01

    Fragile sites are chromosomal loci with a propensity to form gaps or breaks during early mitosis, and their instability is implicated as being causative in certain neurological disorders and cancers. Recent work has demonstrated that the so-called common fragile sites (CFSs) often impair the fait......Fragile sites are chromosomal loci with a propensity to form gaps or breaks during early mitosis, and their instability is implicated as being causative in certain neurological disorders and cancers. Recent work has demonstrated that the so-called common fragile sites (CFSs) often impair...... the faithful disjunction of sister chromatids in mitosis. However, the mechanisms by which CFSs express their fragility, and the cellular factors required to suppress CFS instability, remain largely undefined. Here, we report that the DNA structure-specific nuclease MUS81-EME1 localizes to CFS loci in early...

  14. Electroencephalographic Monitoring in the Pediatric Intensive Care Unit

    OpenAIRE

    Abend, Nicholas S.; Chapman, Kevin E.; Gallentine, William B.; Goldstein, Joshua; Hyslop, Ann E.; Loddenkemper, Tobias; Nash, Kendall B; Riviello, James J.; Hahn, Cecil D.

    2013-01-01

    Continuous EEG monitoring is used with increasing frequency in critically ill children to provide insight into brain function and to identify electrographic seizures. EEG monitoring use often impacts clinical management, most often by identifying electrographic seizures and status epilepticus. Most electrographic seizures have no clinical correlate, and thus would not be identified without EEG monitoring. There is increasing data that electrographic seizures and electrographic status epilepti...

  15. Acoustic monitoring systems tests at Indian Point Unit 1. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Smith, J.R.; Rao, G.V.; Craig, J.

    1979-12-01

    This report describes the results of a program to test acoustic monitoring systems on Indian Point Unit No. 1 under actual plant operating conditions, less the reactor core. The two types of systems evaluated were the monitoring of acoustic emissions generated by growing flaws and the monitoring of acoustic signals from leaks.

  16. Electroencephalographic monitoring in the pediatric intensive care unit.

    Science.gov (United States)

    Abend, Nicholas S; Chapman, Kevin E; Gallentine, William B; Goldstein, Joshua; Hyslop, Ann E; Loddenkemper, Tobias; Nash, Kendall B; Riviello, James J; Hahn, Cecil D

    2013-03-01

    Continuous electroencephalographic (CEEG) monitoring is used with increasing frequency in critically ill children to provide insight into brain function and to identify electrographic seizures. CEEG monitoring use often impacts clinical management, most often by identifying electrographic seizures and status epilepticus. Most electrographic seizures have no clinical correlate, and thus would not be identified without CEEG monitoring. There are increasing data showing that electrographic seizures and electrographic status epilepticus are associated with worse outcome. Seizure identification efficiency may be improved by further development of quantitative electroencephalography trends. This review describes the clinical impact of CEEG data, the epidemiology of electrographic seizures and status epilepticus, the impact of electrographic seizures on outcome, the utility of quantitative electroencephalographic trends for seizure identification, and practical considerations regarding CEEG monitoring.

  17. On the hazard rate process for imperfectly monitored multi-unit systems

    Energy Technology Data Exchange (ETDEWEB)

    Barros, A. [Institut des Sciences et Techonologies de l' Information de Troyes (ISTIT-CNRS), Equipe de Modelisation et Surete des Systemes, Universite de Technologie de Troyes (UTT), 12, rue Marie Curie, BP2060, 10010 Troyes cedex (France)]. E-mail: anne.barros@utt.fr; Berenguer, C. [Institut des Sciences et Techonologies de l' Information de Troyes (ISTIT-CNRS), Equipe de Modelisation et Surete des Systemes, Universite de Technologie de Troyes (UTT), 12, rue Marie Curie, BP2060, 10010 Troyes cedex (France); Grall, A. [Institut des Sciences et Techonologies de l' Information de Troyes (ISTIT-CNRS), Equipe de Modelisation et Surete des Systemes, Universite de Technologie de Troyes (UTT), 12, rue Marie Curie, BP2060, 10010 Troyes cedex (France)

    2005-12-01

    The aim of this paper is to present a stochastic model to characterize the failure distribution of multi-unit systems when the current units state is imperfectly monitored. The definition of the hazard rate process existing with perfect monitoring is extended to the realistic case where the units failure time are not always detected (non-detection events). The so defined observed hazard rate process gives a better representation of the system behavior than the classical failure rate calculated without any information on the units state and than the hazard rate process based on perfect monitoring information. The quality of this representation is, however, conditioned by the monotony property of the process. This problem is mainly discussed and illustrated on a practical example (two parallel units). The results obtained motivate the use of the observed hazard rate process to characterize the stochastic behavior of the multi-unit systems and to optimize for example preventive maintenance policies.

  18. Research on Network-based Integrated Condition Monitoring Unit for Rotating Machinery

    Institute of Scientific and Technical Information of China (English)

    XI Xiao-peng; ZHANG Wen-rui; XI Shuan-min; JING Min-qing; YU Lie

    2004-01-01

    In this paper, a network-based monitoring unit for condition monitoring and fault diagnosis of rotating machinery is designed and implemented. With the technology of DSP( Digital signal processing), TCP/IP, and simultaneous acquisition, a mechanism of multi-process and inter-process communication, the integrating problem of signal acquisition, the data dynamic management and network-based configuration in the embedded condition monitoring system is solved. It offers the input function of monitoring information for network-based condition monitoring and a fault diagnosis system.

  19. Groundwater Monitoring Plan for the Reactor Technology Complex Operable Unit 2-13

    Energy Technology Data Exchange (ETDEWEB)

    Richard P. Wells

    2007-03-23

    This Groundwater Monitoring Plan describes the objectives, activities, and assessments that will be performed to support the on-going groundwater monitoring requirements at the Reactor Technology Complex, formerly the Test Reactor Area (TRA). The requirements for groundwater monitoring were stipulated in the Final Record of Decision for Test Reactor Area, Operable Unit 2-13, signed in December 1997. The monitoring requirements were modified by the First Five-Year Review Report for the Test Reactor Area, Operable Unit 2-13, at the Idaho National Engineering and Environmental Laboratory to focus on those contaminants of concern that warrant continued surveillance, including chromium, tritium, strontium-90, and cobalt-60. Based upon recommendations provided in the Annual Groundwater Monitoring Status Report for 2006, the groundwater monitoring frequency was reduced to annually from twice a year.

  20. Groundwater Monitoring at the 1100-EM-1 Operable Unit

    Energy Technology Data Exchange (ETDEWEB)

    Newcomer, Darrell R.

    2007-04-25

    The purpose of this report is to provide a comprehensive summary of the distribution and trends of volatile organic compound concentrations near USDOE’s Horn Rapids Landfill (HRL). This report focuses mainly on the TCE plume monitored in the top of the unconfined aquifer near the HRL, but also addresses potential breakdown products of TCE. TCE concentrations in deep portions of the unconfined aquifer and the underlying confined aquifer are discussed to show the vertical extent of contamination. This report incorporates TCE data from offsite wells at the AREVA facility south of the Hanford Site. Discussion of TCE in groundwater in the 300 Area is included to differentiate between contaminant plumes and their sources in the 300 Area and near the HRL. Chromium monitoring results from a specific well downgradient of the 1171 Building is also included.

  1. Hydrothermal monitoring data from the Cascade Range, northwestern United States

    Science.gov (United States)

    Ingebritsen, Steven E.; Gelwick, Katrina D.; Randolph-Flagg, Noah G.; Crankshaw, Ilana M.; Lundstrom, Elizabeth A.; McCulloch, Callum L.; Murveit, Anna M.; Newman, Alice C.; Mariner, Robert H.; Bergfeld, D.; Tucker, Dave S.; Schmidt, Mariek E.; Spicer, Kurt R.; Mosbrucker, Adam; Evans, William C.

    2013-01-01

    This database serves as a repository for hydrothermal-monitoring data collected at 25 sites in the U.S. portion of the Cascade Range volcanic arc. These data are intended to quantify baseline hydrothermal variability at most (10 of 12) of the highest-risk volcanoes in the Cascades, as defined by the U.S. Geological Survey’s (USGS’) National Volcanic Early Warning System (NVEWS) report (Ewert and others, 2005).

  2. Nitrogen emissions, deposition, and monitoring in the western United States

    Science.gov (United States)

    Mark E. Fenn; Richard Haeuber; Gail S. Tonnesen; Jill S. Baron; Susanne Grossman-Clarke; Diane Hope; Daniel A. Jaffe; Scott Copeland; Linda Geiser; Heather M. Rueth; James O. Sickman

    2003-01-01

    Nitrogen (N) deposition in the western United States ranges from 1 to 4 kilograms (kg) per hectare (ha) per year over much of the region to as high as 30 to 90 kg per ha per year downwind of major urban and agricultural areas. Primary N emissions sources are transportation, agriculture, and industry. Emissions of N as ammonia are about 50% as great as emissions of N as...

  3. Water Quality Monitoring: An Environmental Studies Unit for Biology 20/30. Student Manual.

    Science.gov (United States)

    Alberta Environment, Edmonton. Environmental Education Resources Branch.

    The objective of this environmental studies unit is to establish a water quality monitoring project for high school students in Alberta while simultaneously providing a unit which meets the objectives of the Biology 20 program (and which may also be used in Biology 10 and 30). Through this project, students assist in the collection,…

  4. A maintenance policy for two-unit parallel systems based on imperfect monitoring information

    Energy Technology Data Exchange (ETDEWEB)

    Barros, Anne [Department Genie des Systems Industiels (GSI), Universite de technologie de Troyes, 12 rue Marie Curie, BP 2060, 10010 Troyes, Cedex (France)]. E-mail: anne.barros@utt.fr; Berenguer, Christophe [Department Genie des Systems Industiels (GSI), Universite de technologie de Troyes, 12 rue Marie Curie, BP 2060, 10010 Troyes, Cedex (France); Grall, Antoine [Department Genie des Systems Industiels (GSI), Universite de technologie de Troyes, 12 rue Marie Curie, BP 2060, 10010 Troyes, Cedex (France)

    2006-02-01

    In this paper a maintenance policy is optimised for a two-unit system with a parallel structure and stochastic dependences. Monitoring problems are taken into account in the optimisation scheme: the failure time of each unit can be not detected with a given probability. Conditions on the system parameters (unit failure rates) and on the non-detection probabilities must be verified to make the optimisation scheme valid. These conditions are clearly identified. Numerical experiments allow to show the relevance of taking into account monitoring problems in the maintenance model.

  5. Improved Power Quality Monitoring through Phasor Measurement Unit Data Interpretation

    DEFF Research Database (Denmark)

    Pertl, Michael; Marinelli, Mattia; Bindner, Henrik W.

    2015-01-01

    the correct actions for operating the system. In future power systems more measuring sensors including phasor measurement units will be available distributed all over the power system. They can and should be utilized to increase the observability of the power system. In this paper the impact of photovoltaic....... The voltage unbalance factor (VUF) could be a ‘new’ observable for a particular power system condition. Information about the actual injected wind power for a certain grid area could be derived without knowing/measuring the real wind power injection....

  6. Pervasive technology in Neonatal Intensive Care Unit: a prototype for newborns unobtrusive monitoring.

    Science.gov (United States)

    Ciani, Oriana; Piccini, Luca; Parini, Sergio; Rullo, Alessia; Bagnoli, Franco; Marti, Patrizia; Andreoni, Giuseppe

    2008-01-01

    Pervasive computing research is introducing new perspectives in a wide range of applications, including healthcare domain. In this study we explore the possibility to realize a prototype of a system for unobtrusive recording and monitoring of multiple biological parameters on premature newborns hospitalized in the Neonatal Intensive Care Unit (NICU). It consists of three different units: a sensitized belt for Electrocardiogram (ECG) and chest dilatation monitoring, augmented with extrinsic transducers for temperature and respiratory activity measure, a device for signals pre-processing, sampling and transmission through Bluetooth(R) (BT) technology to a remote PC station and a software for data capture and post-processing. Preliminary results obtained by monitoring babies just discharged from the ward demonstrated the feasibility of the unobtrusive monitoring on this kind of subjects and open a new scenario for premature newborns monitoring and developmental cares practice in NICU.

  7. Offsite environmental monitoring report: Radiation monitoring around United States nuclear test areas, calendar year 1991

    Energy Technology Data Exchange (ETDEWEB)

    Chaloud, D.J.; Dicey, B.B.; Mullen, A.A.; Neale, A.C.; Sparks, A.R.; Fontana, C.A.; Carroll, L.D.; Phillips, W.G.; Smith, D.D.; Thome, D.J.

    1992-01-01

    This report describes the Offsite Radiation Safety Program conducted during 1991 by the Environmental Protection Agency`s (EPA`s) Environmental Monitoring Systems Laboratory-Las Vegas. This laboratory operates an environmental radiation monitoring program in the region surrounding the Nevada Test Site (NTS) and at former test sites in Alaska, Colorado, Mississippi, Nevada, and New Mexico. The surveillance program is designed to measure levels and trends of radioactivity, if present, in the environment surrounding testing areas to ascertain whether current radiation levels and associated doses to the general public are in compliance with existing radiation protection standards. The surveillance program additionally has the responsibility to take action to protect the health and well being of the public in the event of any accidental release of radioactive contaminants. Offsite levels of radiation and radioactivity are assessed by sampling milk, water, and air; by deploying thermoluminescent dosimeters (TLDs) and using pressurized ion chambers (PICs); and by biological monitoring of animals, food crops, and humans. Personnel with mobile monitoring equipment are placed in areas downwind from the test site prior to each nuclear weapons test to implement protective actions, provide immediate radiation monitoring, and obtain environmental samples rapidly after any occurrence of radioactivity release. Comparison of the measurements and sample analysis results with background levels and with appropriate standards and regulations indicated that there was no radioactivity detected offsite by the various EPA monitoring networks and no exposure above natural background to the population living in the vicinity of the NTS that could be attributed to current NTS activities. Annual and long-term trends were evaluated in the Noble Gas, Tritium, Milk Surveillance, Biomonitoring, TLD, PIC networks, and the Long-Term Hydrological Monitoring Program.

  8. Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus

    Directory of Open Access Journals (Sweden)

    Balmain Allan

    2008-12-01

    Full Text Available Abstract Background Mus spretus diverged from Mus musculus over one million years ago. These mice are genetically and phenotypically divergent. Despite the value of utilizing M. musculus and M. spretus for quantitative trait locus (QTL mapping, relatively little genomic information on M. spretus exists, and most of the available sequence and polymorphic data is for one strain of M. spretus, Spret/Ei. In previous work, we mapped fifteen loci for skin cancer susceptibility using four different M. spretus by M. musculus F1 backcrosses. One locus, skin tumor susceptibility 5 (Skts5 on chromosome 12, shows strong linkage in one cross. Results To identify potential candidate genes for Skts5, we sequenced 65 named and unnamed genes and coding elements mapping to the peak linkage area in outbred spretus, Spret/EiJ, FVB/NJ, and NIH/Ola. We identified polymorphisms in 62 of 65 genes including 122 amino acid substitutions. To look for polymorphisms consistent with the linkage data, we sequenced exons with amino acid polymorphisms in two additional M. spretus strains and one additional M. musculus strain generating 40.1 kb of sequence data. Eight candidate variants were identified that fit with the linkage data. To determine the degree of variation across M. spretus, we conducted phylogenetic analyses. The relatedness of the M. spretus strains at this locus is consistent with the proximity of region of ascertainment of the ancestral mice. Conclusion Our analyses suggest that, if Skts5 on chromosome 12 is representative of other regions in the genome, then published genomic data for Spret/EiJ are likely to be of high utility for genomic studies in other M. spretus strains.

  9. Offsite environmental monitoring report. Radiation monitoring around United States nuclear test areas, calendar year 1982

    Energy Technology Data Exchange (ETDEWEB)

    Black, S. C.; Grossman, R. F.; Mullen, A. A.; Potter, G. D.; Smith, D. D. [comps.

    1983-07-01

    A principal activity of the Offsite Radiological Safety Program is routine environmental monitoring for radioactive materials in various media and for radiation in areas which may be affected by nuclear tests. It is conducted to document compliance with standards, to identify trends, and to provide information to the public. This report summarizes these activities for CY 1982.

  10. Two cases of burns caused by misuse of coagulation unit and monitoring.

    Science.gov (United States)

    Rolly, G

    1978-01-01

    Two cases of severe burns with monitoring apparatus are described. In a female patient of 45 years, a severe third degree burn occurred by misuse of coagulation apparatus (inversion of the poles of an older Bovie apparatus), in the presence of a non-floating ECG monitoring device. A high intensity current was established from the coagulation unit, via the earth plate under the buttocks, to the indifferent electrode placed on the chest, where burns occurred. In an 8 month female baby, having laparotomy for a neuroblastoma, a third degree burn of 5 cm diameter occurred with a non-floating ECG monitor. A twin-wired disposable earth plate was placed just beneath the indifferent ECG electrode on the leg. A burning current was established between the Bovie coagulation unit and the monitor.

  11. 40 CFR 60.1320 - How do I monitor the load of my municipal waste combustion unit?

    Science.gov (United States)

    2010-07-01

    ... municipal waste combustion unit? 60.1320 Section 60.1320 Protection of Environment ENVIRONMENTAL PROTECTION... of Performance for Small Municipal Waste Combustion Units for Which Construction is Commenced After... Monitoring Requirements § 60.1320 How do I monitor the load of my municipal waste combustion unit? (a) If...

  12. Offsite environmental monitoring report: Radiation monitoring around United States nuclear test areas, calendar year 1993

    Energy Technology Data Exchange (ETDEWEB)

    Chaloud, D.J; Daigler, D.M.; Davis, M.G. [and others

    1996-06-01

    This report describes the Offsite Radiation Safety Program conducted during 1993 by the Environmental Protection Agency`s (EPA`s) Environmental Monitoring Systems Laboratory - Las Vegas (EMSL-LV). This laboratory operates an environmental radiation monitoring program in the region surrounding the Nevada Test Site (NTS) and at former test sites in Alaska, Colorado, Mississippi, Nevada, and New Mexico. The surveillance program is designed to measure levels and trends of radioactivity, if present, in the environment surrounding testing areas to ascertain whether current radiation levels and associated doses to the general public are in compliance with existing radiation protection standards. The surveillance program additionally has the responsibility to take action to protect the health and well being of the public in the event of any accidental release of radioactive contaminants. Offsite levels of radiation and radioactivity are assessed by sampling milk, water, and air; by deploying thermoluminescent dosimeters (TLDs) and using pressurized ionization chambers (PICs); by biological monitoring of foodstuffs including animal tissues and food crops; and by measurement of radioactive material deposited in humans.

  13. Offsite environmental monitoring report: Radiation monitoring around United States nuclear test areas, calendar year 1997

    Energy Technology Data Exchange (ETDEWEB)

    Davis, M.G.; Flotard, R.D.; Fontana, C.A.; Hennessey, P.A.; Maunu, H.K.; Mouck, T.L.; Mullen, A.A.; Sells, M.D.

    1999-01-01

    This report describes the Offsite Radiological Environmental Monitoring Program (OREMP) conducted during 1997 by the US Environmental Protection Agency`s (EPAs), Radiation and Indoor Environments National Laboratory, Las Vegas, Nevada. This laboratory operated an environmental radiation monitoring program in the region surrounding the Nevada Test Site (NTS) and at former test sites in Alaska, Colorado, Mississippi, Nevada, and New Mexico. The surveillance program is designed to measure levels and trends of radioactivity, if present, in the environment surrounding testing areas to ascertain whether current radiation levels and associated doses to the general public are in compliance with existing radiation protection standards. The surveillance program additionally has the responsibility to take action to protect the health and well being of the public in the event of any accidental release of radioactive contaminants. Offsite levels of radiation and radioactivity are assessed by sampling and analyzing milk, water, and air; by deploying and reading thermoluminescent dosimeters (TLDs); and using pressurized ionization chambers (PICs) to measure ambient gamma exposure rates with a sensitivity capable of detecting low level exposures not detected by other monitoring methods.

  14. Acoustic emission monitoring of hot functional testing: Watts Bar Unit 1 Nuclear Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Hutton, P.H.; Dawson, J.F.; Friesel, M.A.; Harris, J.C.; Pappas, R.A.

    1984-06-01

    Acoustic emission (AE) monitoring of selected pressure boundary areas at TVA's Watts Bar, Unit 1 Nuclear Power Plant during hot functional preservice testing is described in this report. The report deals with background, methodology, and results. The work discussed here is a major milestone in a program supported by NRC to develop and demonstrate application of AE monitoring for continuous surveillance of reactor pressure boundaries to detect and evaluate growing flaws. The subject work demonstrated that anticipated problem areas can be overcome. Work is continuing toward AE monitoring during reactor operation.

  15. Analysis of free flap complications and utilization of intensive care unit monitoring.

    Science.gov (United States)

    Cornejo, Agustin; Ivatury, Sirinivas; Crane, Curtis N; Myers, John G; Wang, Howard T

    2013-09-01

    We aimed to determine the optimal time for intensive care unit (ICU) monitoring after free flap reconstruction based on the timing of surgical complications. We reviewed retrospectively 179 free flaps in 170 subjects during an 8-year period at University Hospital. Thirty-seven flaps were reoperated due to vascular (n = 16, 8.9%) and nonvascular complications (n = 21, 11.7%). Vascular complications presented earlier relative to nonvascular complications (10.8 versus 99.3 hours). The flap survival rate was 93.2% with a mean ICU length of stay of 6.2 days. The lack of standardized monitoring protocols can lead to overutilization of ICU. Sometimes, flap monitoring is not the limiting factor, as patients with other comorbidities necessitate longer ICU stays. However, our study suggests that close monitoring of flaps seems most critical during the first 24 to 48 hours, when most thrombotic complications occur and prompt identification and re-exploration is critical. Some thrombosis and most hematomas present within 72 hours, and thus close monitoring is still warranted. We suggest close monitoring of free flaps in the ICU or dedicated flap monitoring unit where nursing can check the flap on an every-1-to-2-hour basis for the first 72 hours postoperatively to assure optimal surveillance of any potential problems.

  16. Surveillance Monitoring Management for General Care Units: Strategy, Design, and Implementation.

    Science.gov (United States)

    McGrath, Susan P; Taenzer, Andreas H; Karon, Nancy; Blike, George

    2016-07-01

    The growing number of monitoring devices, combined with suboptimal patient monitoring and alarm management strategies, has increased "alarm fatigue," which have led to serious consequences. Most reported alarm man- agement approaches have focused on the critical care setting. Since 2007 Dartmouth-Hitchcock (Lebanon, New Hamp- shire) has developed a generalizable and effective design, implementation, and performance evaluation approach to alarm systems for continuous monitoring in general care settings (that is, patient surveillance monitoring). In late 2007, a patient surveillance monitoring system was piloted on the basis of a structured design and implementation approach in a 36-bed orthopedics unit. Beginning in early 2009, it was expanded to cover more than 200 inpatient beds in all medicine and surgical units, except for psychiatry and labor and delivery. Improvements in clinical outcomes (reduction of unplanned transfers by 50% and reduction of rescue events by more than 60% in 2008) and approximately two alarms per patient per 12-hour nursing shift in the original pilot unit have been sustained across most D-H general care units in spite of increasing patient acuity and unit occupancy. Sample analysis of pager notifications indicates that more than 85% of all alarm conditions are resolved within 30 seconds and that more than 99% are resolved before escalation is triggered. The D-H surveillance monitoring system employs several important, generalizable features to manage alarms in a general care setting: alarm delays, static thresholds set appropriately for the prevalence of events in this setting, directed alarm annunciation, and policy-driven customization of thresholds to allow clinicians to respond to needs of individual patients. The systematic approach to design, implementation, and performance management has been key to the success of the system.

  17. Offsite environmental monitoring report; radiation monitoring around United States nuclear test areas, Calendar Year 1996

    Energy Technology Data Exchange (ETDEWEB)

    Davis, M.G.; Flotard, R.D.; Fontana, C.A.; Huff, P.A.; Maunu, H.K.; Mouck, T.L.; Mullen, A.A.; Sells, M.D.

    1997-08-01

    This report describes the Offsite Radiation Safety Program. This laboratory operated an environmental radiation monitoring program in the region surrounding the Nevada Test Site (NTS) and at former test sites in Alaska, Colorado, Mississippi, Nevada, and New Mexico. The surveillance program is designed to measure levels and trends of radioactivity, if present, in the environment surrounding testing areas to ascertain whether current radiation levels and associated doses to the general public are in compliance with existing radiation protection standards. The surveillance program additionally has the responsibility to take action to protect the health and well being of the public in the event of any accidental release of radioactive contaminants. Offsite levels of radiation and radioactivity are assessed by sampling milk, water, and air; by deploying thermoluminescent dosimeters (TLDs); and using pressurized ionization chambers (PICs). No nuclear weapons testing was conducted in 1996 due to the continuing nuclear test moratorium. During this period, R and IE personnel maintained readiness capability to provide direct monitoring support if testing were to be resumed and ascertained compliance with applicable EPA, DOE, state, and federal regulations and guidelines. Comparison of the measurements and sample analysis results with background levels and with appropriate standards and regulations indicated that there was no airborne radioactivity from diffusion or resuspension detected by the various EPA monitoring networks surrounding the NTS. There was no indication of potential migration of radioactivity to the offsite area through groundwater and no radiation exposure above natural background was received by the offsite population. All evaluated data were consistent with previous data history.

  18. Cardiac arrhythmias in stroke unit patients. Evaluation of the cardiac monitoring data.

    Science.gov (United States)

    Fernández-Menéndez, S; García-Santiago, R; Vega-Primo, A; González Nafría, N; Lara-Lezama, L B; Redondo-Robles, L; Montes-Montes, M; Riveira-Rodríguez, M C; Tejada-García, J

    2016-06-01

    Cardiac arrhythmias are frequent in acute stroke. Stroke units are widely equipped with cardiac monitoring systems. Pre-existing heart diseases and heart-brain interactions may be implicated in causing cardiac arrhythmias in acute stroke. This article analyses cardiac arrhythmias detected in patients hospitalised in a stroke unit. Prospective observational study of consecutive patients admitted to a stroke unit with cardiac monitoring. We collected clinical data from patients and the characteristics of their cardiac arrhythmias over a 1-year period (2013). Time of arrhythmia onset, associated predisposing factors, and the therapeutic decisions made after detection of arrhythmia were examined. All patients underwent continuous cardiac monitoring during no less than 48hours. Of a total of 332 patients admitted, significant cardiac arrhythmias occurred in 98 patients (29.5%) during their stay in the stroke unit. Tachyarrhythmia (ventricular tachyarrhythmias, supraventricular tachyarrhythmias, complex ventricular ectopy) was present in 90 patients (27.1%); bradyarrhythmia was present in 13 patients (3.91%). Arrhythmias were independently associated with larger size of brain lesion and older age. In 10% of the patient total, therapeutic actions were taken after detection of significant cardiac arrhythmias. Most events occurred within the first 48hours after stroke unit admission. Systematic cardiac monitoring in patients with acute stroke is useful for detecting clinically relevant cardiac arrhythmias. Incidence of arrhythmia is higher in the first 48hours after stroke unit admission. Age and lesion size were predicted appearance of arrhythmias. Detection of cardiac arrhythmias in a stroke unit has important implications for treatment. Copyright © 2014 Sociedad Española de Neurología. Published by Elsevier España, S.L.U. All rights reserved.

  19. Automated chemical monitoring in new projects of nuclear power plant units

    Science.gov (United States)

    Lobanok, O. I.; Fedoseev, M. V.

    2013-07-01

    The development of automated chemical monitoring systems in nuclear power plant units for the past 30 years is briefly described. The modern level of facilities used to support the operation of automated chemical monitoring systems in Russia and abroad is shown. Hardware solutions suggested by the All-Russia Institute for Nuclear Power Plant Operation (which is the General Designer of automated process control systems for power units used in the AES-2006 and VVER-TOI Projects) are presented, including the structure of additional equipment for monitoring water chemistry (taking the Novovoronezh 2 nuclear power plant as an example). It is shown that the solutions proposed with respect to receiving and processing of input measurement signals and subsequent construction of standard control loops are unified in nature. Simultaneous receipt of information from different sources for ensuring that water chemistry is monitored in sufficient scope and with required promptness is one of the problems that have been solved successfully. It is pointed out that improved quality of automated chemical monitoring can be supported by organizing full engineering follow-up of the automated chemical monitoring system's equipment throughout its entire service life.

  20. Board of Regents' Montana University System (MUS) Strategic Plan 2016

    Science.gov (United States)

    Montana University System, 2016

    2016-01-01

    The Montana University System Strategic Plan is the primary planning document of the Board of Regents. The Plan sets forth an agenda for higher education in Montana by delineating the strategic directions, goals, and objectives that guide the Montana University System (MUS). In July 2006, after several years of study, public dialogue, and internal…

  1. De ontogenese van de darm bij Mus musculus L.

    NARCIS (Netherlands)

    Pleeging, Johannes Hermanus

    1975-01-01

    Een onderzoek werd verricht naar de ontwikkeling van de darm bij de muis (Mus Musculus L, stam C57 BL/RIJ en stam C57 BL/OSCN), aan embryonen van opeenvolgende leeftijden. Hiertoe werden van de maagdarmtractus van de embryonen 8 tot 16,5 dag p.c. reconstructies vervaardigd. Enige waarnemingen werden

  2. Phylogenetic relationship and time of divergence of Mus terricolor with reference to other Mus species

    Indian Academy of Sciences (India)

    MAHUA RUDRA; BISHWANATH CHATTERJEE; MIN BAHADUR

    2016-06-01

    Mitochondrial DNA control region ofMus terricolor , three aboriginal speciesM. spretus ,M. macedonicus ,M. spicilegus ;the Asian lineageM. caroli ,M. cervicolor ,M. cookii ; and the two house mice,M. musculus domesticusandM. m. castaneuswere analysed to estimate the substitution rate, phylogenetic relationship and the probable time of divergence. Results showedthatM. spretus ,M. caroliandM. terricolorare highly diverged from each other (caroli /terricolor =0.146,caroli /spretus =0.147 andterricolor /spretus =0.122), whereasM. spretusshowed less divergence with two house mice species (0.070 and0.071). Sequence divergence betweenM. terricolorand the Palearctic group were found to be ranging from 0.121 to 0.134.Phylogenetic analysis by minimum evolution, neighbour-joining, unweighed pair group method with arithmetic mean andmaximum parsimony showed almost similar topology. Two major clusters were found, one included the Asian lineage,M.caroli ,M. cookiiandM. cervicolorand the other included the house miceM. m. domesticus ,M. m. castaneusand the aboriginalmiceM. macedonicusandM. spicilegusalong withM. spretus , forming the Palearctic clade.M. terricolorwas positionedbetween the Palearctic and Asian clades. Results showed that Palearctic -terricolorand the Asian lineages diverged 5.47million years ago (Mya), whileM. terricolorhad split around 4.63 Mya from their ancestor.M. cervicolor ,M. cookiiandM.carolidiverged between 4.70 and 3.36 Mya, which indicates thatM. terricolorand the Asian lineages evolved simultaneously.M. spretusis expected to have diverged nearly 2.9 Mya from their most recent common ancestor

  3. Nurse Competence on Physiologic Monitors Use: Toward Eliminating Alarm Fatigue in Intensive Care Units.

    Science.gov (United States)

    Sowan, Azizeh K; Vera, Ana G; Fonseca, Elma I; Reed, Charles C; Tarriela, Albert F; Berndt, Andrea E

    2017-01-01

    Studies on nurse competence on alarm management are a few and tend to be focused on limited skills. In response to Phase II of implementing the National Patient Safety Goal on clinical alarm systems safety, this study assessed nurses' perceived competence on physiologic monitors use in intensive care units (ICUs) and developed and validated a tool for this purpose. This descriptive study took place in a Magnet hospital in a Southwestern state of the U.S. A Nurse Competence on Philips Physiologic Monitors Use Survey was created and went through validation by 13 expert ICU nurses. The survey included 5 subscales with 59 rated items and two open-ended questions. Items on the first 4 subscales reflect most common tasks nurses perform using physiologic monitors. Items on the fifth subscale (advanced functions) reflect rarely used skills and were included to understand the scope of utilizing advanced physiologic monitors' features. Thirty nurses from 4 adult ICUs were invited to respond to the survey. Thirty nurses (100%) responded to the survey. The majority of nurses were from Neuro (47%) and Surgical Trauma (37%) ICUs. The data supported the high reliability and construct validity of the survey. At least one (3%) to 8 nurses (27%) reported lack of confidence on each item on the survey. On the first four subscales, 3% - 40% of the nurses reported they had never heard of or used 27 features/functions on the monitors. No relationships were found between subscales' scores and demographic characteristics (p > .05). Nurses asked for training on navigating the central-station monitor and troubleshooting alarms, and the use of unit-specific super users to tailor training to users' needs. This is the first study to create and test a list of competencies for physiologic monitors use. Rigorous, periodic and individualized training is essential for safe and appropriate use of physiologic monitors and to decrease alarm fatigue. Training should be comprehensive to include all

  4. 40 CFR Table 6 to Subpart Ppp of... - Process Vents From Continuous Unit Operations-Monitoring, Recordkeeping, and Reporting Requirements

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Process Vents From Continuous Unit Operations-Monitoring, Recordkeeping, and Reporting Requirements 6 Table 6 to Subpart PPP of Part 63... Subpart PPP of Part 63—Process Vents From Continuous Unit Operations—Monitoring, Recordkeeping, and...

  5. Design and accomplishment for the monitoring unit of the sup 6 sup 0 Co train freight inspection system

    CERN Document Server

    Cong Peng

    2002-01-01

    The sup 6 sup 0 Co railway cargo inspection system has super automaticity. And the monitoring unit is an important part of the automatic control system. The author introduces the idea of designing the monitoring unit in detail and accomplishes a new-style unit which is different from the traditional one. The monitoring unit which is highly integrated, easy to be mounted and debugged and convenient to be operated and maintained has play an excellent role in the work of the whole inspection system

  6. Estimation of the error between experimental tetanic force curves of MUs of rat medial gastrocnemius muscle and their models by summation of equal successive contractions.

    Science.gov (United States)

    Raikova, Rositsa; Aladjov, Hristo; Krutki, Piotr; Celichowski, Jan

    2016-01-01

    More accurate muscle models require appropriate modelling of individual twitches of motor units (MUs) and their unfused tetanic contractions. It was shown in our previous papers, using a few MUs, that modelling of unfused tetanic force curves by summation of equal twitches is not accurate, especially for slow MUs. The aim of this study was to evaluate this inaccuracy using a statistical number of MUs of the rat medial gastrocnemius muscle (15 of slow, 15 of fast resistant and 15 of fast fatigable type). Tetanic contractions were evoked by trains of 41 stimuli at random interpulse intervals and different mean frequencies, resembling discharge patterns observed during natural muscle activity. The tetanic curves were calculated by the summation of equal twitches according to the respective experimental patterns. The previously described 6-parameter analytical function for twitch modelling was used. Comparisons between the experimental and the modelled curves were made using two coefficients: the fit coefficient and the area coefficient. The errors between modelled and experimental tetanic forces were substantially different between the three MU types. The error was the most significant for slow MUs, which develop much higher forces in real contractions than could be predicted based on the summation of equal twitches, while the smallest error was observed for FF MUs--their recorded tetanic forces were similar to those predicted by modelling. The obtained results indicate the importance of the inclusion of the type-specific non-linearity in the summation of successive twitch-like contractions of MUs in order to increase the reliability of modelling skeletal muscle force.

  7. Monitoring of health care personnel employee and occupational health immunization program practices in the United States.

    Science.gov (United States)

    Carrico, Ruth M; Sorrells, Nikka; Westhusing, Kelly; Wiemken, Timothy

    2014-01-01

    Recent studies have identified concerns with various elements of health care personnel immunization programs, including the handling and management of the vaccine. The purpose of this study was to assess monitoring processes that support evaluation of the care of vaccines in health care settings. An 11-question survey instrument was developed for use in scripted telephone surveys. State health departments in all 50 states in the United States and the District of Columbia were the target audience for the surveys. Data from a total of 47 states were obtained and analyzed. No states reported an existing monitoring process for evaluation of health care personnel immunization programs in their states. Our assessment indicates that vaccine evaluation processes for health care facilities are rare to nonexistent in the United States. Identifying existing practice gaps and resultant opportunities for improvements may be an important safety initiative that protects patients and health care personnel.

  8. Dosimetric properties of a scanned beam microtron at low monitor unit settings: importance for conformal therapy.

    Science.gov (United States)

    Humm, J L; Larsson, A; Lief, E P

    1996-03-01

    The dosimetric stability, linearity, dose rate dependence, and flatness of both photon and electron beams have been evaluated for a racetrack microtron at low monitor unit settings. For photons, the variation in dosimetric output about the mean is 3% at 20 cm, even at only 3 MU, in contrast with other scanned beam accelerators. Broad electron beams on the microtron are created by the superposition of the elementary beam pulses either directly from the scan magnets, or after their broadening through a scattering foil. The dosimetric instability both with and without the foil was less than 0.6% for both the 25- and 50-MeV electrons. Dose nonlinearity was microtron exhibits dosimetric properties which fulfill the recommendations of Task Groups 21 and 25. Based on the stability of the scanned beam at low monitor unit settings, the microtron can be used for 3-D conformal therapy with both photons and electrons.

  9. MODULAR CAUSTIC SIDE SOLVENT EXTRACTION UNIT (MCU) GAMMA MONITORS SYSTEM FINAL REPORT

    Energy Technology Data Exchange (ETDEWEB)

    Casella, V

    2005-12-15

    The Department of Energy (DOE) selected Caustic-Side Solvent Extraction (CSSX) as the preferred technology for the removal of radioactive cesium from High-Level Waste (HLW) at the Savannah River Site (SRS). Before the full-scale Salt Waste Processing Facility (SWPF) becomes operational, the Closure Business Unit (CBU) plans to process a portion of dissolved saltcake waste through a Modular CSSX Unit (MCU). This work was derived from Technical Task Request SP-TTR-2004-00013, ''Gamma Monitor for MCU''. The deliverables for this task are the hardware and software for the gamma monitors and a report summarizing the testing and acceptance of this equipment for use in the MCU. Gamma-ray monitors are required to: (1) Measure the Cs-137 concentration in the decontaminated salt solution before entering the DSS (Decontaminated Salt Solution) Hold Tank, (2) Measure the Cs-137 concentration in the strip effluent before entering the Strip Effluent Hold Tank, (3) Verify proper operation of the solvent extraction system by verifying material balance within the process (The DSS Hold Tank Cs-137 concentration will be very low and the Cs-137 concentration in the Strip Effluent Hold Tank will be fifteen times higher than the Cs-137 concentration in the Feed Tank.) Sodium iodide monitors are used to measure the Cs-137 concentration in the piping before the DSS Hold tank, while GM monitors are used for Cs-137 measurements before the Strip Effluent Hold Tank. Tungsten shields were designed using Monte Carlo calculations and fabricated to reduce the process background radiation at the detector positions. These monitors were calibrated with NIST traceable standards that were specially made to be the same as the piping being monitored. Since this gamma ray monitoring system is unique, specially designed software was written and acceptance tested by Savannah River National Laboratory personnel. The software is a LabView-based application that serves as a unified

  10. Salamander chytrid fungus (Batrachochytrium salamandrivorans) in the United States—Developing research, monitoring, and management strategies

    Science.gov (United States)

    Grant, Evan H. Campbell; Muths, Erin L.; Katz, Rachel A.; Canessa, Stefano; Adams, Michael J.; Ballard, Jennifer R.; Berger, Lee; Briggs, Cheryl J.; Coleman, Jeremy; Gray, Matthew J.; Harris, M. Camille; Harris, Reid N.; Hossack, Blake R.; Huyvaert, Kathryn P.; Kolby, Jonathan E.; Lips, Karen R.; Lovich, Robert E.; McCallum, Hamish I.; Mendelson, Joseph R.; Nanjappa, Priya; Olson, Deanna H.; Powers, Jenny G.; Richgels, Katherine L.D.; Russell, Robin E.; Schmidt, Benedikt R.; Spitzen-van der Sluijs, Annemarieka; Watry, Mary Kay; Woodhams, Douglas C.; White, C. LeAnn

    2016-01-20

    The recently (2013) identified pathogenic chytrid fungus, Batrachochytrium salamandrivorans (Bsal), poses a severe threat to the distribution and abundance of salamanders within the United States and Europe. Development of a response strategy for the potential, and likely, invasion of Bsal into the United States is crucial to protect global salamander biodiversity. A formal working group, led by Amphibian Research and Monitoring Initiative (ARMI) scientists from the U.S. Geological Survey (USGS) Patuxent Wildlife Research Center, Fort Collins Science Center, and Forest and Rangeland Ecosystem Science Center, was held at the USGS Powell Center for Analysis and Synthesis in Fort Collins, Colorado, United States from June 23 to June 25, 2015, to identify crucial Bsal research and monitoring needs that could inform conservation and management strategies for salamanders in the United States. Key findings of the workshop included the following: (1) the introduction of Bsal into the United States is highly probable, if not inevitable, thus requiring development of immediate short-term and long-term intervention strategies to prevent Bsal establishment and biodiversity decline; (2) management actions targeted towards pathogen containment may be ineffective in reducing the long-term spread of Bsal throughout the United States; and (3) early detection of Bsal through surveillance at key amphibian import locations, among high-risk wild populations, and through analysis of archived samples is necessary for developing management responses. Top research priorities during the preinvasion stage included the following: (1) deployment of qualified diagnostic methods for Bsal and establishment of standardized laboratory practices, (2) assessment of susceptibility for amphibian hosts (including anurans), and (3) development and evaluation of short- and long-term pathogen intervention and management strategies. Several outcomes were achieved during the workshop, including development

  11. 2008 Groundwater Monitoring Report Project Shoal Area, Corrective Action Unit 447

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-03-01

    This report presents the 2008 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) at the Project Shoal Area (PSA) Subsurface Corrective Action Unit (CAU) 447 located in Churchill County, Nevada. Responsibility for the environmental site restoration of the PSA was transferred from the DOE Office of Environmental Management to LM on October 1, 2006. The environmental restoration process and corrective action strategy for CAU 447 are conducted in accordance with the Federal Facility Agreement and Consent Order (FFACO 1996, as amended February 2008) entered into by DOE, the U.S. Department of Defense, and the State of Nevada. The corrective action strategy for the site includes proof of concept monitoring in support of site closure. This report summarizes investigation activities associated with CAU 447 that were conducted at the site during 2008. This is the second groundwater monitoring report prepared by LM for the PSA

  12. 2010 Groundwater Monitoring Report Project Shoal Area, Corrective Action Unit 447

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-02-01

    This report presents the 2010 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) at the Project Shoal Area (PSA) Subsurface Corrective Action Unit (CAU) 447 in Churchill County, Nevada. Responsibility for the environmental site restoration of the PSA was transferred from the DOE Office of Environmental Management to LM on October 1, 2006. The environmental restoration process and corrective action strategy for CAU 447 are conducted in accordance with the Federal Facility Agreement and Consent Order (FFACO 1996, as amended March 2010) entered into by DOE, the U.S. Department of Defense, and the State of Nevada. The corrective action strategy for the site includes monitoring in support of site closure. This report summarizes the results from the groundwater monitoring program during fiscal year 2010.

  13. 2008 Groundwater Monitoring Report Central Nevada Test Area, Corrective Action Unit 443

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-03-01

    This report presents the 2008 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) for the Central Nevada Test Area (CNTA) Subsurface Corrective Action Unit (CAU) 443. Responsibility for the environmental site restoration of the CNTA was transferred from the DOE Office of Environmental Management (DOE-EM) to DOE-LM on October 1, 2006. The environmental restoration process and corrective action strategy for CAU 443 are conducted in accordance with the Federal Facility Agreement and Consent Order (FFACO 2005) entered into by DOE, the U.S. Department of Defense, and the State of Nevada. The corrective action strategy for the site includes proof-of-concept monitoring in support of site closure. This report summarizes investigation activities associated with CAU 443 that were conducted at the site during fiscal year 2008. This is the second groundwater monitoring report prepared by DOE-LM for the CNTA.

  14. Monitor units are not predictive of neutron dose for high-energy IMRT

    Directory of Open Access Journals (Sweden)

    Hälg Roger A

    2012-08-01

    Full Text Available Abstract Background Due to the substantial increase in beam-on time of high energy intensity-modulated radiotherapy (>10 MV techniques to deliver the same target dose compared to conventional treatment techniques, an increased dose of scatter radiation, including neutrons, is delivered to the patient. As a consequence, an increase in second malignancies may be expected in the future with the application of intensity-modulated radiotherapy. It is commonly assumed that the neutron dose equivalent scales with the number of monitor units. Methods Measurements of neutron dose equivalent were performed for an open and an intensity-modulated field at four positions: inside and outside of the treatment field at 0.2 cm and 15 cm depth, respectively. Results It was shown that the neutron dose equivalent, which a patient receives during an intensity-modulated radiotherapy treatment, does not scale with the ratio of applied monitor units relative to an open field irradiation. Outside the treatment volume at larger depth 35% less neutron dose equivalent is delivered than expected. Conclusions The predicted increase of second cancer induction rates from intensity-modulated treatment techniques can be overestimated when the neutron dose is simply scaled with monitor units.

  15. Spread-out Bragg peak and monitor units calculation with the Monte Carlo code MCNPX.

    Science.gov (United States)

    Hérault, J; Iborra, N; Serrano, B; Chauvel, P

    2007-02-01

    The aim of this work was to study the dosimetric potential of the Monte Carlo code MCNPX applied to the protontherapy field. For series of clinical configurations a comparison between simulated and experimental data was carried out, using the proton beam line of the MEDICYC isochronous cyclotron installed in the Centre Antoine Lacassagne in Nice. The dosimetric quantities tested were depth-dose distributions, output factors, and monitor units. For each parameter, the simulation reproduced accurately the experiment, which attests the quality of the choices made both in the geometrical description and in the physics parameters for beam definition. These encouraging results enable us today to consider a simplification of quality control measurements in the future. Monitor Units calculation is planned to be carried out with preestablished Monte Carlo simulation data. The measurement, which was until now our main patient dose calibration system, will be progressively replaced by computation based on the MCNPX code. This determination of Monitor Units will be controlled by an independent semi-empirical calculation.

  16. Independent dose per monitor unit review of eight U.S.A. proton treatment facilities

    Energy Technology Data Exchange (ETDEWEB)

    Moyers, M. F., E-mail: MFMoyers@roadrunner.com [Colton, California 92354 (United States); Ibbott, G. S.; Grant, R. L.; Summers, P. A.; Followill, D. S. [Department of Radiation Physics, University of Texas – M. D. Anderson Cancer Center, Houston, Texas 77030 (United States)

    2014-01-15

    Purpose: Compare the dose per monitor unit at different proton treatment facilities using three different dosimetry methods. Methods: Measurements of dose per monitor unit were performed by a single group at eight facilities using 11 test beams and up to six different clinical portal treatment sites. These measurements were compared to the facility reported dose per monitor unit values. Results: Agreement between the measured and reported doses was similar using any of the three dosimetry methods. Use of the ICRU 59 N{sub D,w} based method gave results approximately 3% higher than both the ICRU 59 N{sub X} and ICRU 78 (TRS-398) N{sub D,w} based methods. Conclusions: Any single dosimetry method could be used for multi-institution trials with similar conformity between facilities. A multi-institutional trial could support facilities using both the ICRU 59 N{sub X} based and ICRU 78 (TRS-398) N{sub D,w} based methods but use of the ICRU 59 N{sub D,w} based method should not be allowed simultaneously with the other two until the difference is resolved.

  17. Independent dose per monitor unit review of eight U.S.A. proton treatment facilities.

    Science.gov (United States)

    Moyers, M F; Ibbott, G S; Grant, R L; Summers, P A; Followill, D S

    2014-01-01

    Compare the dose per monitor unit at different proton treatment facilities using three different dosimetry methods. Measurements of dose per monitor unit were performed by a single group at eight facilities using 11 test beams and up to six different clinical portal treatment sites. These measurements were compared to the facility reported dose per monitor unit values. Agreement between the measured and reported doses was similar using any of the three dosimetry methods. Use of the ICRU 59 ND,w based method gave results approximately 3% higher than both the ICRU 59 NX and ICRU 78 (TRS-398) ND,w based methods. Any single dosimetry method could be used for multi-institution trials with similar conformity between facilities. A multi-institutional trial could support facilities using both the ICRU 59 NX based and ICRU 78 (TRS-398) ND,w based methods but use of the ICRU 59 ND,w based method should not be allowed simultaneously with the other two until the difference is resolved.

  18. Monitoring Solar-terrestrial Interaction at the United Nations Office at Vienna

    Science.gov (United States)

    Gadimova, Sharafat; Haubold, Hans

    Earth's ionosphere reacts strongly to the intense X-ray and ultraviolet radiation released by the Sun during solar events. Stanford's Solar Center, Electrical Engineering Department developed inexpensive space weather monitors that scholars around the world can use to track changes to the Earth's ionosphere. Two versions of the monitors exist -a low-cost version named SID (Sudden Ionospheric Disturbances) designed to detect solar flares; and a more sensitive version named AWESOME (Atmospheric Weather Electromagnetic System of Observation, Modeling, and Education) that provides both solar and nighttime research-quality data. Through the United Nations Basic Space Science Initiative (UNBSSI), such monitors have been deployed to high schools and universities in developing nations of the world for the International Space Weather Initiative (ISWI, see http://www.stil.bas.bg/ISWI/). The monitors come preassem-bled, the hosts build their own antenna, and provide a computer to record the data and an internet connection to share their data with worldwide network of SIDs and AWESOMEs. These networks are advancing the understanding of the fundamental heliophysical processes that govern the Sun, Earth and heliosphere, particularly phenomena of space weather. Mon-itoring the fundamental processes responsible for solar-terrestrial coupling are vital to being able to understand the influence of the Sun on the near-Earth environment. A SID monitor is successfully operating at the United Nations Office at Vienna (UNOV) and will be extended to an AWESOME shortly. This project will also be supported by the programme on global naviga-tion satellite systems (GNSS) applications, implemented through the International Committee on GNSS (ICG, see http://www.icgsecretariat.org).

  19. Monitoring dental-unit-water-line output water by current in-office test kits.

    Science.gov (United States)

    Lal, Sham; Singhrao, Sim K; Bricknell, Matt; Pearce, Mark; Morton, L H Glyn; Ahmed, Waqar; Crean, St John

    2014-08-01

    The importance of monitoring contamination levels in the output water of dental-unit-water-lines (DUWLs) is essential as they are prone to developing biofilms that may contaminate water that is used to treat patients, with opportunistic pathogens such as species of Legionella, Pseudomonas and others. Dentists and practice staff are also at risk of being infected by means of cross-infection due to aerosols generated from DUWL water. The unit of measurement for the microbial contamination of water by aerobic mesophilic heterotrophic bacteria is the colony-forming unit per millilitre (cfu/ml) of water. The UK has its own guidelines set by the Department of Health for water discharged from DUWL to be between 100 and 200 cfu/ml of water. The benchmark or accepted standard laboratory test is by microbiological culture on R2A agar plates. However, this is costly and not convenient for routine testing in dental practices. A number of commercial indicator tests are used in dental surgeries, but they were not developed for the dental market and serve only to indicate gross levels of contamination when used outside of the manufacturer's recommended incubation period. The aim of this article is to briefly review the universal problem of DUWL contamination with microbial biofilms and to update dental professionals on the availability of currently available commercial in-office monitoring systems for aerobic mesophilic heterotrophic bacteria and to discuss their limitations for testing water samples in assuring compliance with recommended guidelines.

  20. Continuous 'Passive' flow-proportional monitoring of drainage using a new modified Sutro weir (MSW) unit.

    Science.gov (United States)

    Vendelboe, Anders Lindblad; Rozemeijer, Joachim; de Jonge, Lis Wollesen; de Jonge, Hubert

    2016-03-01

    In view of their crucial role in water and solute transport, enhanced monitoring of agricultural subsurface drain tile systems is important for adequate water quality management. However, existing monitoring techniques for flow and contaminant loads from tile drains are expensive and labour intensive. The aim of this study was to develop a cost-effective and simple method for monitoring loads from tile drains. The Flowcap is a modified Sutro weir (MSW) unit that can be attached to the outlet of tile drains. It is capable of registering total flow, contaminant loads and flow-averaged concentrations. The MSW builds on a modern passive sampling technique that responds to hydraulic pressure and measures average concentrations over time (days to months) for various substances. Mounting the samplers in the MSW allowed a flow-proportional part of the drainage to be sampled. Laboratory testing yielded high linear correlation between the accumulated sampler flow, q total, and accumulated drainage flow, Q total (r (2) > 0.96). The slope of these correlations was used to calculate the total drainage discharge from the sampled volume, and therefore contaminant load. A calibration of the MSW under controlled laboratory condition was needed before interpretation of the monitoring results was possible. The MSW does not require a shed, electricity, or maintenance. This enables large-scale monitoring of contaminant loads via tile drains, which can improve contaminant transport models and yield valuable information for the selection and evaluation of mitigation options to improve water quality. Results from this type of monitoring can provide data for the evaluation and optimisation of best management practices in agriculture in order to produce the highest yield without water quality and recipient surface waters being compromised.

  1. Clinical Trial of an Educational Program to Decrease Monitor Alarms in a Medical Intensive Care Unit.

    Science.gov (United States)

    Brantley, Arian; Collins-Brown, Sandra; Kirkland, Jasmine; Knapp, Meghan; Pressley, Jackie; Higgins, Melinda; McMurtry, James P

    2016-07-01

    Clinical research to identify effective interventions for decreasing nonactionable alarms has been limited. The objective of this study was to determine if a staff educational program on customizing alarm settings on bedside monitors decreased alarms in a medical intensive care unit (MICU). A preintervention, postintervention, nonequivalent group design was used to evaluate an educational program on alarm management in a convenience sample of MICU nurses. A 15-minute session was provided in a 1-week period. The outcome variable (number of alarms for low oxygen saturation via pulse oximetry [SpO2]) was determined from monitor log files adjusted by patient census. Data were collected for 15 days before and after the intervention. χ(2) analysis was used, with P less than .05 considered significant. After 1 week of education, low SpO2 alarms decreased from 502 to 306 alarms per patient monitored per day, a 39% reduction (P alarm settings to patients' clinical condition decreased common monitor alarms by 39%. ©2016 American Association of Critical-Care Nurses.

  2. Satellite gravity measurement monitoring terrestrial water storage change and drought in the continental United States

    Science.gov (United States)

    Yi, Hang; Wen, Lianxing

    2016-01-01

    We use satellite gravity measurements in the Gravity Recovery and Climate Experiment (GRACE) to estimate terrestrial water storage (TWS) change in the continental United States (US) from 2003 to 2012, and establish a GRACE-based Hydrological Drought Index (GHDI) for drought monitoring. GRACE-inferred TWS exhibits opposite patterns between north and south of the continental US from 2003 to 2012, with the equivalent water thickness increasing from -4.0 to 9.4 cm in the north and decreasing from 4.1 to -6.7 cm in the south. The equivalent water thickness also decreases by -5.1 cm in the middle south in 2006. GHDI is established to represent the extent of GRACE-inferred TWS anomaly departing from its historical average and is calibrated to resemble traditional Palmer Hydrological Drought Index (PHDI) in the continental US. GHDI exhibits good correlations with PHDI in the continental US, indicating its feasibility for drought monitoring. Since GHDI is GRACE-based and has minimal dependence of hydrological parameters on the ground, it can be extended for global drought monitoring, particularly useful for the countries that lack sufficient hydrological monitoring infrastructures on the ground.

  3. 2009 Groundwater Monitoring Report Central Nevada Test Area, Corrective Action Unit 443

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-09-01

    This report presents the 2009 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) for the Central Nevada Test Area (CNTA) Subsurface Corrective Action Unit (CAU) 443. Responsibility for the environmental site restoration of CNTA was transferred from the DOE Office of Environmental Management to LM on October 1, 2006. The environmental restoration process and corrective action strategy for CAU 443 are conducted in accordance with the Federal Facility Agreement and Consent Order entered into by DOE, the U.S. Department of Defense, and the State of Nevada. The corrective action strategy for the site includes proof-of-concept monitoring in support of site closure. This report summarizes investigation activities associated with CAU 443 that were conducted at the site from October 2008 through December 2009. It also represents the first year of the enhanced monitoring network and begins the new 5-year proof-of-concept monitoring period that is intended to validate the compliance boundary

  4. 2010 Groundwater Monitoring Report Central Nevada Test Area, Corrective Action Unit 443

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-02-01

    This report presents the 2010 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) for the Central Nevada Test Area (CNTA) Subsurface Corrective Action Unit (CAU) 443. Responsibility for the environmental site restoration of CNTA was transferred from the DOE Office of Environmental Management to LM on October 1, 2006. The environmental restoration process and corrective action strategy for CAU 443 are conducted in accordance with the Federal Facility Agreement and Consent Order entered into by DOE, the U.S. Department of Defense, and the State of Nevada. The corrective action strategy for the site includes proof-of-concept monitoring in support of site closure. This report summarizes investigation activities associated with CAU 443 that were conducted at the site from December 2009 through December 2010. It also represents the second year of the enhanced monitoring network and the 5-year proof-of-concept monitoring period that is intended to validate the compliance boundary

  5. 2009 Groundwater Monitoring Report Project Shoal Area, Corrective Action Unit 447

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-03-01

    This report presents the 2009 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) at the Project Shoal Area (PSA) Subsurface Corrective Action Unit (CAU) 447 in Churchill County, Nevada. Responsibility for the environmental site restoration of the PSA was transferred from the DOE Office of Environmental Management to LM on October 1, 2006. The environmental restoration process and corrective action strategy for CAU 447 are conducted in accordance with the Federal Facility Agreement and Consent Order (FFACO 1996, as amended February 2008) entered into by DOE, the U.S. Department of Defense, and the State of Nevada. The corrective action strategy for the site includes monitoring in support of site closure. This report summarizes investigation activities associated with CAU 447 that were conducted at the PSA during fiscal year 2009.

  6. Improvement of a sensor unit for wrist blood pressure monitoring system

    Science.gov (United States)

    Koo, Sangjun; Kwon, Jongwon; Park, Yongman; Ayuzenara, Odgerel; Kim, Hiesik

    2007-12-01

    A blood pressure sensor unit for ubiquitous healthcare monitoring was newly developed. The digital wrist band-type blood pressure devices for home are popular already in the market. It is useful for checking blood pressure level at home and control of hypertension. Especially, it is very essential home device to check the health condition of blood circulation disease. Nowadays many product types are available. But the measurement of blood pressure is not accurate enough compared with the mechanical type. It needs to be upgraded to assure the precise health data enough to use in the hospital. The structure, feature and output signal of capacitor type pressure sensors are analyzed. An improved design of capacitor sensor is suggested. It shows more precise health data after use on a wrist band type health unit. They can be applied for remote u-health medical service.

  7. Monitoring of bacterial contamination of dental unit water lines using adenosine triphosphate bioluminescence.

    Science.gov (United States)

    Watanabe, A; Tamaki, N; Yokota, K; Matsuyama, M; Kokeguchi, S

    2016-12-01

    Bacterial contamination of dental unit waterlines (DUWLs) was evaluated using ATP bioluminescence analysis and a conventional culture method. Water samples (N=44) from DUWLs were investigated for heterotrophic bacteria by culture on R2A agar, which gave counts ranging from 1.4×10(3) to 2.7×10(5) cfu/mL. The ATP bioluminescence results for DUWL samples ranged from 6 to 1189 relative light units and could be obtained within 1min; these correlated well with the culture results (r=0.727-0.855). We conclude that the results of the ATP bioluminescence assay accurately reflect the results of conventional culture-based testing. This method is potentially useful for rapid and simple monitoring of DUWL bacterial contamination.

  8. Confirmation of the occurrence of Mus neavei in South Africa

    Directory of Open Access Journals (Sweden)

    C.H. Newbery

    2002-12-01

    Full Text Available Neave’s mouse, Mus neavei (Thomas, 1910, occurs in the Democratic Republic of Congo, Tanzania, Zambia, Mozambique, Zimbabwe and South Africa (Petter 1981; Musser & Carleton 1993, with the latter record based on material from owl pellets taken at Makapansgat (Pocock 1974. Pocock’s record was disputed by Swanepoel et al. (1980, and in the absence of complete voucher specimens, the occurrence of this species in South Africa was regarded as doubtful. However, it was supported by Meester et al. (1986 and accepted by Musser & Carleton (1993.

  9. 40 CFR Table 3 to Subpart Uuu of... - Continous Monitoring Systems for Metal HAP Emissions From Catalytic Cracking Units

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Continous Monitoring Systems for Metal... Units Pt. 63, Subpt. UUU, Table 3 Table 3 to Subpart UUU of Part 63—Continous Monitoring Systems for... CFR 60.102 a. Over 20,000 barrels per day fresh feed capacity Electrostatic precipitator Continuous...

  10. Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation

    DEFF Research Database (Denmark)

    Ghamrasni, S El; Cardoso, R; Li, L;

    2016-01-01

    Rad54 and Mus81 mammalian proteins physically interact and are important for the homologous recombination DNA repair pathway; however, their functional interactions in vivo are poorly defined. Here, we show that combinatorial loss of Rad54 and Mus81 results in hypersensitivity to DNA......-damaging agents, defects on both the homologous recombination and non-homologous DNA end joining repair pathways and reduced fertility. We also observed that while Mus81 deficiency diminished the cleavage of common fragile sites, very strikingly, Rad54 loss impaired this cleavage to even a greater extent....... The inefficient repair of DNA double-strand breaks (DSBs) in Rad54(-/-)Mus81(-/-) cells was accompanied by elevated levels of chromosome missegregation and cell death. Perhaps as a consequence, tumor incidence in Rad54(-/-)Mus81(-/-) mice remained comparable to that in Mus81(-/-) mice. Our study highlights...

  11. Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response

    DEFF Research Database (Denmark)

    Xing, Meichun; Wang, Xiaohui; Palmai-Pallag, Timea;

    2015-01-01

    The MUS81 protein belongs to a conserved family of DNA structure-specific nucleases that play important roles in DNA replication and repair. Inactivation of the Mus81 gene in mice has no major deleterious consequences for embryonic development, although cancer susceptibility has been reported. We...... have investigated the role of MUS81 in human cells by acutely depleting the protein using shRNAs. We found that MUS81 depletion from human fibroblasts leads to accumulation of ssDNA and a constitutive DNA damage response that ultimately activates cellular senescence. Moreover, we show that MUS81...... is required for efficient replication fork progression during an unperturbed S-phase, and for recovery of productive replication following replication stalling. These results demonstrate essential roles for the MUS81 nuclease in maintenance of replication fork integrity....

  12. 78 FR 7411 - Vessel Monitoring Systems (VMS); Certification of New VMS Unit for Use in Northeast Fisheries

    Science.gov (United States)

    2013-02-01

    ... National Oceanic and Atmospheric Administration RIN 0648-XC470 Vessel Monitoring Systems (VMS); Certification of New VMS Unit for Use in Northeast Fisheries AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA), Commerce. ACTION: Notice of VMS unit...

  13. Predictive monitoring for respiratory decompensation leading to urgent unplanned intubation in the neonatal intensive care unit.

    Science.gov (United States)

    Clark, Matthew T; Vergales, Brooke D; Paget-Brown, Alix O; Smoot, Terri J; Lake, Douglas E; Hudson, John L; Delos, John B; Kattwinkel, John; Moorman, J Randall

    2013-01-01

    Infants admitted to the neonatal intensive care unit (NICU), and especially those born with very low birth weight (VLBW; endotracheal intubation and mechanical ventilation. Intubation and mechanical ventilation are associated with increased morbidity, particularly in urgent unplanned cases. We tested the hypothesis that the systemic response associated with respiratory decompensation can be detected from physiological monitoring and that statistical models of bedside monitoring data can identify infants at increased risk of urgent unplanned intubation. We studied 287 VLBW infants consecutively admitted to our NICU and found 96 events in 51 patients, excluding intubations occurring within 12 h of a previous extubation. In order of importance in a multivariable statistical model, we found that the characteristics of reduced O(2) saturation, especially as heart rate was falling; increased heart rate correlation with respiratory rate; and the amount of apnea were all significant independent predictors. The predictive model, validated internally by bootstrap, had a receiver-operating characteristic area of 0.84 ± 0.04. We propose that predictive monitoring in the NICU for urgent unplanned intubation may improve outcomes by allowing clinicians to intervene noninvasively before intubation is required.

  14. MODULAR CAUSTIC SIDE SOLVENT EXTRACTION UNIT GAMMA MONITORS SYSTEM FINAL REPORT

    Energy Technology Data Exchange (ETDEWEB)

    Casella, V

    2007-06-25

    The Department of Energy (DOE) selected Caustic-Side Solvent Extraction (CSSX) as the preferred technology for the removal of radioactive cesium from High-Level Waste (HLW) at the Savannah River Site (SRS). Before the full-scale Salt Waste Processing Facility (SWPF) becomes operational, the liquid Waste Organization (LWO) plans to process a portion of dissolved saltcake waste through a Modular CSSX Unit (MCU). This work was derived from Technical Task Request SP-TTR-2004-00013, ''Gamma Monitor for MCU.'' The deliverables for this task are the hardware and software for the gamma monitors and a report summarizing the testing and acceptance of this equipment for use in the MCU. Revision of this report is a deliverable in Technical Task Report SP-TTR-2006-00010, ''NaI Shield Box Testing.'' Gamma-ray monitors were developed to: {lg_bullet} Measure the Cs-137 concentration in the decontaminated salt solution before entering the DSS (Decontaminated Salt Solution) Hold Tank, {lg_bullet} Measure the Cs-137 concentration in the strip effluent before entering the Strip Effluent Hold Tank, {lg_bullet} Verify proper operation of the solvent extraction system by verifying material balance within the process (The DSS Hold Tank Cs-137 concentration will be very low and the Cs-137 concentration in the Strip Effluent Hold Tank will be approximately fifteen times higher than the Cs-137 concentration in the Feed Tank.)

  15. Groundwater Monitoring Report Central Nevada Test Area, Corrective Action Unit 443

    Energy Technology Data Exchange (ETDEWEB)

    None

    2008-04-01

    This report presents the 2007 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) for the Central Nevada Test Area (CNTA) Corrective Action Unit (CAU) 443. Responsibility for the environmental site restoration of the CNTA was transferred from the DOE Office of Environmental Management (DOE-EM) to DOE-LM on October 1, 2006. Requirements for CAU 443 are specified in the Federal Facility Agreement and Consent Order (FFACO 2005) entered into by DOE, the U.S. Department of Defense, and the State of Nevada and includes groundwater monitoring in support of site closure. This is the first groundwater monitoring report prepared by DOE-LM for the CNTA The CNTA is located north of U.S. Highway 6, approximately 30 miles north of Warm Springs in Nye County, Nevada (Figure 1). Three emplacement boreholes, UC-1, UC-3, and UC-4, were drilled at the CNTA for underground nuclear weapons testing. The initial underground nuclear test, Project Faultless, was conducted in borehole UC-1 at a depth of 3,199 feet (ft) (975 meters) below ground surface on January 19, 1968. The yield of the Project Faultless test was estimated to be 0.2 to 1 megaton (DOE 2004). The test resulted in a down-dropped fault block visible at land surface (Figure 2). No further testing was conducted at the CNTA, and the site was decommissioned as a testing facility in 1973.

  16. Recommended methods for range-wide monitoring of prairie dogs in the United States

    Science.gov (United States)

    McDonald, Lyman L.; Stanley, Thomas R.; Otis, David L.; Biggins, Dean E.; Stevens, Patricia D.; Koprowski, John L.; Ballard, Warren

    2011-01-01

    One of the greatest challenges for conserving grassland, prairie scrub, and shrub-steppe ecosystems is maintaining prairie dog populations across the landscape. Of the four species of prairie dogs found in the United States, the Utah prairie dog (Cynomys parvidens) is listed under the Endangered Species Act (ESA) as threatened, the Gunnison's prairie dog (C. gunnisoni) is a candidate for listing in a portion of its range, and the black-tailed prairie dog (C. ludovicianus) and white-tailed prairie dog (C. leucurus) have each been petitioned for listing at least once in recent history. Although the U.S. Fish and Wildlife Service (USFWS) determined listing is not warranted for either the black-tailed prairie dog or white-tailed prairie dog, the petitions and associated reviews demonstrated the need for the States to monitor and manage for self-sustaining populations. In response to these findings, a multi-State conservation effort was initiated for the nonlisted species which included the following proposed actions: (1) completing an assessment of each prairie dog species in each State, (2) developing a range-wide monitoring protocol for each species using a statistically valid sampling procedure that would allow comparable analyses across States, and (3) monitoring prairie dog status every 3-5 years depending upon the species. To date, each State has completed an assessment and currently is monitoring prairie dog status; however, for some species, the inconsistency in survey methodology has made it difficult to compare data year-to-year or State-to-State. At the Prairie Dog Conservation Team meeting held in November 2008, there was discussion regarding the use of different methods to survey prairie dogs. A recommendation from this meeting was to convene a panel in a workshop-type forum and have the panel review the different methods being used and provide recommendations for range-wide monitoring protocols for each species of prairie dog. Consequently, the Western

  17. MUS81 is associated with cell proliferation and cisplatin sensitivity in serous ovarian cancer

    Energy Technology Data Exchange (ETDEWEB)

    Xie, Suhong; Zheng, Hui [Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai (China); Department of Oncology, Shanghai Medical College, Fudan University, Shanghai (China); Wen, Xuemei [Department of Oncology, Shanghai Medical College, Fudan University, Shanghai (China); Sun, Jiajun; Wang, Yanchun; Gao, Xiang; Guo, Lin [Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai (China); Department of Oncology, Shanghai Medical College, Fudan University, Shanghai (China); Lu, Renquan, E-mail: lurenquan@126.com [Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai (China); Department of Oncology, Shanghai Medical College, Fudan University, Shanghai (China)

    2016-08-05

    The dysfunction of DNA damage repair (DDR) pathway contributes to tumorigenesis and drug-resistance in cancer. MUS81 is a member of the conserved xeroderma pigmentosum group F (XPF) family protein of endonucleases, which is important to the DDR pathway. However, the role of MUS81 in the development of ovarian cancer remains uncertain. To explore the expression of MUS81 and its association to serous ovarian cancer (SOC), 43 biopsies of SOC patients were detected by qRT-PCR, and 29 specimens were further performed by immunohistochemistry analysis. Here, we observed that MUS81 was over-expressed in SOC tissues at both transcript and protein levels, and the expression level of MUS81 protein in ovarian cancer cell lines was also higher than that in human normal ovarian surface epithelial cell line (HOSEpiC). We also found that down-regulation of MUS81 expression in ovarian cancer cells inhibited cell proliferation and colony formation ability, and influenced cell cycle progression. Moreover, inhibition of MUS81 expression induced cellular senescence and enhanced the antitumor effect of cisplatin. Down-regulation of MUS81 expression could suppress the growth and development of SOC. These results indicate that MUS81 might play important roles in the progression of SOC and influence the antitumor effect of cisplatin. - Highlights: • MUS81 was overexpression in serous ovarian cancer (SOC). • Meanwhile down-regulation of inhibited cell proliferation and influenced cell cycle progression. • Inhibition of MUS81 induced cell cellular senescence and enhanced the antitumor effect of cisplatin. • Down-regulation of MUS81 expression could suppress the growth and development of SOC.

  18. [Monitoring infection at the intensive care unit--a multicenter pilot study].

    Science.gov (United States)

    Lackner, F; Wewalka, G; Rotter, M; Kilian, J; Hummel, E; Hartenauer, U; Gähler, R; Scherzer, E; Pauser, G

    1989-06-01

    During a period of 3 months an infection survey was carried out in 4 intensive care units (ICUs), 2 in Vienna, Austria, and one each in Ulm and Münster, Federal Republic of Germany, using a common protocol. A total of 329 patients was monitored prospectively. This pilot study was performed to evaluate the usefulness of parameters included in the monitoring form. It was attempted to characterize the patient populations of the four units. Mean duration of stay (1-12 days), mortality (8-26%), leading diagnosis upon admission, intubation rate (41-91%) and use of pulmonary artery catheter (12-35%) were distinctly different. The rate of patients admitted already with an infection was 9-43%, septicemia was diagnosed in up to 27% of the diseased. The rate of infection acquired in the unit was between 12 and 37%, the most frequent types were bronchopneumonia, septicemia and urinary tract infection. When septicemia patients were compared to non-septicemia patients who had been admitted for more than 3 days, it appeared that the latter stayed significantly shorter at the ICU and showed less frequently bronchopneumonia or urinary tract infection at the time of admission. Septicemia patients acquired more frequently additional infections like broncho-pneumonia or urinary tract infection while staying at the ICU. The median day of onset of septicemia was the fifth day and only in a quarter of cases diagnosis could be supported by a positive blood culture. The use of antibiotics in the 4 ICUs is compared and shows marked differences. Based upon experience with this type of infection survey a new modified protocol is introduced, which displays the time course of documented events.

  19. A Methodology for Protective Vibration Monitoring of Hydropower Units Based on the Mechanical Properties.

    Science.gov (United States)

    Nässelqvist, Mattias; Gustavsson, Rolf; Aidanpää, Jan-Olov

    2013-07-01

    It is important to monitor the radial loads in hydropower units in order to protect the machine from harmful radial loads. Existing recommendations in the standards regarding the radial movements of the shaft and bearing housing in hydropower units, ISO-7919-5 (International Organization for Standardization, 2005, "ISO 7919-5: Mechanical Vibration-Evaluation of Machine Vibration by Measurements on Rotating Shafts-Part 5: Machine Sets in Hydraulic Power Generating and Pumping Plants," Geneva, Switzerland) and ISO-10816-5 (International Organization for Standardization, 2000, "ISO 10816-5: Mechanical Vibration-Evaluation of Machine Vibration by Measurements on Non-Rotating Parts-Part 5: Machine Sets in Hydraulic Power Generating and Pumping Plants," Geneva, Switzerland), have alarm levels based on statistical data and do not consider the mechanical properties of the machine. The synchronous speed of the unit determines the maximum recommended shaft displacement and housing acceleration, according to these standards. This paper presents a methodology for the alarm and trip levels based on the design criteria of the hydropower unit and the measured radial loads in the machine during operation. When a hydropower unit is designed, one of its design criteria is to withstand certain loads spectra without the occurrence of fatigue in the mechanical components. These calculated limits for fatigue are used to set limits for the maximum radial loads allowed in the machine before it shuts down in order to protect itself from damage due to high radial loads. Radial loads in hydropower units are caused by unbalance, shape deviations, dynamic flow properties in the turbine, etc. Standards exist for balancing and manufacturers (and power plant owners) have recommendations for maximum allowed shape deviations in generators. These standards and recommendations determine which loads, at a maximum, should be allowed before an alarm is sent that the machine needs maintenance. The radial

  20. Application for verification of monitor units of the treatment planning system; Aplicacion para la verificacion de unidades monitor del sistema de planificacion de tratamientos

    Energy Technology Data Exchange (ETDEWEB)

    Suero Rodrigo, M. A.; Marques Fraguela, E.

    2011-07-01

    Current estimates algorithms achieve acceptable degree of accuracy. However, operate on the basis of un intuitive models. It is therefore necessary to verify the calculation of monitor units of the treatment planning system (PTS) with those obtained by other independent formalisms. To this end, we have developed an application based on factorization formalism that automates the calculation of dose.

  1. Geothermal resource areas database for monitoring the progress of development in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, J.D.; Lepman, S.R.; Leung, K.; Phillips, S.L.

    1981-01-01

    The Geothermal Resource Areas Database (GRAD) and associated data system provide broad coverage of information on the development of geothermal resources in the United States. The system is designed to serve the information requirements of the National Progress Monitoring System. GRAD covers development from the initial exploratory phase through plant construction and operation. Emphasis is on actual facts or events rather than projections and scenarios. The selection and organization of data are based on a model of geothermal development. Subjects in GRAD include: names and addresses, leases, area descriptions, geothermal wells, power plants, direct use facilities, and environmental and regulatory aspects of development. Data collected in the various subject areas are critically evaluated, and then entered into an on-line interactive computer system. The system is publically available for retrieval and use. The background of the project, conceptual development, software development, and data collection are described here. Appendices describe the structure of the database in detail.

  2. Measured Test-Driven Development: Using Measures to Monitor and Control the Unit Development

    Directory of Open Access Journals (Sweden)

    Y. Dubinsky

    2007-01-01

    Full Text Available We analyze Test Driven Development (TDD from cognitive and social perspectives. Based on our analysis, we suggest a technique for controlling and monitoring the TDD process by examining measures that relate to the size and complexity of both code and tests. We call this approach Measured TDD. The motivation for TDD arose from practitioners' tendency to rush into code production, skipping the required testing needed to manufacture quality products. The motivation for Measured TDD is based on difficulties encountered by practitioners in applying TDD. Specifically, with the need to frequently refactor the unit, after every few test and code steps have been performed. We found that the suggested technique enables developers to gain better control over the development process.

  3. Monitoring of Microscopic Filamentous Fungi in Indoor Air of Transplant Unit.

    Science.gov (United States)

    Holý, Ondřej; Matoušková, Ivanka; Kubátová, Alena; Hamal, Petr; Svobodová, Lucie; Jurásková, Eva; Raida, Luděk

    2015-12-01

    The aim of the study was to control the microbial contamination of indoor air monitored monthly at the Transplant Unit of the University Hospital Olomouc from August 2010 to July 2011. The unit is equipped with a three-stage air filtration system with HEPA filters. The MAS-100 air sampler (Merck, GER) was used. Twenty locations were singled out for the purposes of collecting a total of 720 samplings of the indoor air. Swabs of the HVAC diffusers at the sampling locations were always carried out after the sampling of the indoor air. In total, 480 samples of the indoor air were taken for Sabouraud chloramphenicol agar. In 11 cases (2.29%) the cultivation verified the presence of microscopic filamentous fungi. Only two cases involved the sanitary facilities of a patient isolation box; the other positive findings were from the facilities. The most frequent established genus was Aspergillus spp. (4x), followed by Trichoderma spp. (2x) and Penicillium spp. (2x), Paecilomyces spp., Eurotium spp., and Chrysonilia spp. (1x each). In 2 cases the cultivation established sterile aerial mycelium, unfortunately no further identification was possible. A total of 726 swabs of HVAC diffusers were collected (2 positive-0.28%). The study results demonstrated the efficacy of the HVAC equipment. With the continuing increase in the number of severely immunocompromised patients, hospitals are faced with the growing problem of invasive aspergillosis and other opportunistic infections. Preventive monitoring of microbial air contaminants is of major importance for the control of invasive aspergillosis. Copyright© by the National Institute of Public Health, Prague 2015.

  4. The mini mobile environmental monitoring unit: a novel bio-assessment tool.

    Science.gov (United States)

    Kolok, Alan S; Miller, Jeffrey T; Schoenfuss, Heiko L

    2012-01-01

    This paper introduces a new bio-assessment tool, the mini-mobile environmental monitoring unit (MMU). The MMU is a portable, lightweight, energy-efficient, miniaturized laboratory that provides a low-flow system for on-site exposure of aquatic animals to local receiving waters in a protected, controllable environment. Prototypes of the MMU were tested twice in week-long studies conducted during the summers of 2008 and 2009, and in a 12-day study in 2010. In 2008, fathead minnows and polar organic chemical integrative samplers (POCIS) were deployed downstream from the Hastings, Nebraska wastewater treatment plant (WWTP), a waterway known to contain estrogenic contaminants in biologically active concentrations. In 2009, minnows and POCIS were deployed downstream, upstream and within the Grand Island, Nebraska WWTP, a site where the estrogenic contaminants had been detected, but were found at levels below those necessary to directly impact fish. In 2010, an advanced prototype was tested at the Sauk Center, Minnesota WWTP to compare its performance with that of traditional fish exposure methods including caged fish and static-renewal laboratory testing of effluent. Results from the prototype illustrate the capabilities of the MMU and offer an inexpensive monitoring tool to integrate the effects of pollutant sources with temporally varying composition and concentration.

  5. Investment in epilepsy monitoring units improves epilepsy care—experience in a regional neuroscience centre

    LENUS (Irish Health Repository)

    McGinty, RN

    2017-08-01

    An evaluation of the clinical yield of inpatient long-term video-EEG (vEEG) in a new epilepsy monitoring unit (EMU) was undertaken, with findings compared to the centre’s prior method of bedside vEEG recording in a standard neurology ward, as reported in 2004. A retrospective analysis of neurophysiology reports for all adults who underwent elective vEEG monitoring in the EMU at Cork University Hospital between January 2015 and July 2016 was conducted. Of 115 vEEG studies in the EMU, 100 (87.0%) were deemed diagnostically conclusive, 14 (12.2%) failed to catch any clinical events and showed normal EEG throughout, and one (0.9%) captured spells of unclear clinical significance—the corresponding figures reported in 2004 for bedside vEEGs were 21.3%, 77% and 1.6%, respectively. The EMU offers a more effective method of recording inpatient vEEG, which aids decision-making and improves clinical outcomes. Some evidence-based measures which could further enhance diagnostic yield are discussed.

  6. A far-view intensive care unit monitoring display enables faster triage.

    Science.gov (United States)

    Görges, Matthias; Kück, Kai; Koch, Sven H; Agutter, Jim; Westenskow, Dwayne R

    2011-01-01

    Although nurses perform the majority of the clinical tasks in an intensive care unit, current patient monitors were not designed to support a nurse's workflow. Nurses constantly triage patients, deciding which patient is currently in the most need of care. To make this decision, nurses must observe the patient's vital signs and therapeutic device information from multiple sources. To obtain this information, they often have to enter the patient's room. This study addresses 3 hypotheses. Information provided by far-view monitoring displays (1) reduces the amount of time to determine which patient needs care first, (2) increases the accuracy of assigning priority to the right patient, and (3) reduces nurses mental workload. We developed 2 far-view displays to be read from a distance of 3 to 5 m without entering the patient's room. Both display vital signs, trends, alarms, infusion pump status, and therapy support indicators. To evaluate the displays, nurses were asked to use the displays to decide which of 2 patients required their attention first. They made 60 decisions: 20 with each far-view display and 20 decisions with a standard patient monitor next to an infusion pump. Sixteen nurses (median age of 27.5 years with 2.75 years of experience) participated in the study. Using the 2 far-view displays, nurses more accurately and rapidly identified stable patients and syringe pumps that were nearly empty. Median decision times were 11.3 and 12.4 seconds for the 2 far-view displays and 17.2 seconds for the control display. The 2 far-view displays reduced median decision-making times by 4.8 to 5.9 seconds, increased accuracy in assignment of priority in 2 of 7 patient conditions, and reduced nurses' frustration with the triaging task. In a clinical setting, the proposed far-view display might reduce nurses' mental workload and thereby increase patient safety.

  7. Range and modulation dependencies for proton beam dose per monitor unit calculations

    Science.gov (United States)

    Hsi, Wen C.; Schreuder, Andries N.; Moyers, Michael F.; Allgower, Chris E.; Farr, Jonathan B.; Mascia, Anthony E.

    2009-01-01

    Calculations of dose per monitor unit (D∕MU) are required in addition to measurements to increase patient safety in the clinical practice of proton radiotherapy. As in conventional photon and electron therapy, the D∕MU depends on several factors. This study focused on obtaining range and modulation dependence factors used in D∕MU calculations for the double scattered proton beam line at the Midwest Proton Radiotherapy Institute. Three dependencies on range and one dependency on modulation were found. A carefully selected set of measurements was performed to discern these individual dependencies. Dependencies on range were due to: (1) the stopping power of the protons passing through the monitor chamber; (2) the reduction of proton fluence due to nuclear interactions within the patient; and (3) the variation of proton fluence passing through the monitor chamber due to different source-to-axis distances (SADs) for different beam ranges. Different SADs are produced by reconfigurations of beamline elements to provide different field sizes and ranges. The SAD effect on the D∕MU varies smoothly as the beam range is varied, except at the beam range for which the first scatterers are exchanged and relocated to accommodate low and high beam ranges. A geometry factor was devised to model the SAD variation effect on the D∕MU. The measured D∕MU variation as a function of range can be predicted within 1% using the three modeled dependencies on range. Investigation of modulated beams showed that an analytical formula can predict the D∕MU dependency as a function of modulation to within 1.5%. Special attention must be applied when measuring the D∕MU dependence on modulation to avoid interplay between range and SAD effects. PMID:19292004

  8. Range and modulation dependencies for proton beam dose per monitor unit calculations

    Energy Technology Data Exchange (ETDEWEB)

    Hsi, Wen C.; Schreuder, Andries N.; Moyers, Michael F.; Allgower, Chris E.; Farr, Jonathan B.; Mascia, Anthony E. [Midwest Proton Radiotherapy Institute, Bloomington, Indiana 47408 and University Florida Proton Therapy Institute, Jacksonville, Florida 32206 (United States); ProCure Treatment Centers, Inc., Bloomington, Indiana 47404 (United States); Proton Therapy, Inc., Colton, California 92324 (United States); Midwest Proton Radiotherapy Institute, Bloomington, Indiana 47408 (United States); Midwest Proton Radiotherapy Institute, Bloomington, Indiana 47408 and Westdeutsches Protonentherapiezentrum, Universitaetsklinikum, Hufelandstrasse 55, 45147 Essen (Germany); Midwest Proton Radiotherapy Institute, Bloomington, Indiana 47408 (United States)

    2009-02-15

    Calculations of dose per monitor unit (D/MU) are required in addition to measurements to increase patient safety in the clinical practice of proton radiotherapy. As in conventional photon and electron therapy, the D/MU depends on several factors. This study focused on obtaining range and modulation dependence factors used in D/MU calculations for the double scattered proton beam line at the Midwest Proton Radiotherapy Institute. Three dependencies on range and one dependency on modulation were found. A carefully selected set of measurements was performed to discern these individual dependencies. Dependencies on range were due to: (1) the stopping power of the protons passing through the monitor chamber; (2) the reduction of proton fluence due to nuclear interactions within the patient; and (3) the variation of proton fluence passing through the monitor chamber due to different source-to-axis distances (SADs) for different beam ranges. Different SADs are produced by reconfigurations of beamline elements to provide different field sizes and ranges. The SAD effect on the D/MU varies smoothly as the beam range is varied, except at the beam range for which the first scatterers are exchanged and relocated to accommodate low and high beam ranges. A geometry factor was devised to model the SAD variation effect on the D/MU. The measured D/MU variation as a function of range can be predicted within 1% using the three modeled dependencies on range. Investigation of modulated beams showed that an analytical formula can predict the D/MU dependency as a function of modulation to within 1.5%. Special attention must be applied when measuring the D/MU dependence on modulation to avoid interplay between range and SAD effects.

  9. Soursop Leaves (Annona muricata Folium on Mice (Mus musculus Fetus

    Directory of Open Access Journals (Sweden)

    Yunita Suryani

    2014-02-01

    Full Text Available Background: Soursop leaf ethanol extract (Annona muricata (L Folium contains acetogenins which are cytotoxic and have the ability to halt cell growth. This study aimed to understand whether acetogenins have teratogenic effects on mice fetus (Mus musculus. Methods: This study was performed at the Pharmacology and Therapy Laboratory of the Faculty of Medicine, Universitas Padjadjaran, Bandung, between October and November 2012. The study was an experimental laboratory study utilizing 27 pregnant mice which were divided into 3 groups. The first group was the negative control, the second was given soursop leaf ethanol extract at pre-implantation phase (day 1 to 5 and the third had the extract provided in the organogenesis phase (day 6 to 15. Laparotomy was performed on the 19th day of pregnancy. The parameters used were the number of implantation, the number of live and dead or resorbed fetus, the weight and length of the fetus, as well as the macroscopic external morphology abnormalities. The data gained from test subjects were compared to those of the control group. The statistical test used was the normality tes with the Kolmogorov-Smirnov method which was then followed by T-test or Mann-Whitney statistical tests. Results: The experiment exhibited significant differences in the weight and length of the fetus (p-value 0.000, proving that soursop leaf ethanol extract could inhibit intrauterine growth. Aside from that, external morphological abnormalities such as hemorrhage on the head, face, neck, back, forelimbs, hindlimbs, and microcephaly were also found. Conclusion: The soursop leaf ethanol extract (Annona muricata (L Folium has a teratogenic effect on mouse (Mus musculus fetus. [AMJ.2014;1(1:48–53

  10. Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response

    DEFF Research Database (Denmark)

    Xing, Meichun; Wang, Xiaohui; Palmai-Pallag, Timea

    2015-01-01

    The MUS81 protein belongs to a conserved family of DNA structure-specific nucleases that play important roles in DNA replication and repair. Inactivation of the Mus81 gene in mice has no major deleterious consequences for embryonic development, although cancer susceptibility has been reported. We...

  11. Long-term dust climatology in the western United States reconstructed from routine aerosol ground monitoring

    Directory of Open Access Journals (Sweden)

    D. Q. Tong

    2012-06-01

    Full Text Available This study introduces an observation-based dust identification approach and applies it to reconstruct long-term dust climatology in the western United States. Long-term dust climatology is important for quantifying the effects of atmospheric aerosols on regional and global climate. Although many routine aerosol monitoring networks exist, it is often difficult to obtain dust records from these networks, because these monitors are either deployed far away from dust active regions (most likely collocated with dense population or contaminated by anthropogenic sources and other natural sources, such as wildfires and vegetation detritus. Here we propose an approach to identify local dust events relying solely on aerosol mass and composition from general-purpose aerosol measurements. Through analyzing the chemical and physical characteristics of aerosol observations during satellite-detected dust episodes, we select five indicators to be used to identify local dust records: (1 high PM10 concentrations; (2 low PM2.5/PM10 ratio; (3 higher concentrations and percentage of crustal elements; (4 lower percentage of anthropogenic pollutants; and (5 low enrichment factors of anthropogenic elements. After establishing these identification criteria, we conduct hierarchical cluster analysis for all validated aerosol measurement data over 68 IMPROVE sites in the western United States. A total of 182 local dust events were identified over 30 of the 68 locations from 2000 to 2007. These locations are either close to the four US Deserts, namely the Great Basin Desert, the Mojave Desert, the Sonoran Desert, and the Chihuahuan Desert, or in the high wind power region (Colorado. During the eight-year study period, the total number of dust events displays an interesting four-year activity cycle (one in 2000–2003 and the other in 2004–2007. The years of 2003, 2002 and 2007 are the three most active dust periods, with 46, 31 and 24

  12. Development of a unit suitable for corrosion monitoring in district heating systems. Experiences with the LOCOR-cell test method

    DEFF Research Database (Denmark)

    Andersen, Asbjørn; Hilbert, Lisbeth Rischel

    2004-01-01

    the purpose, background and gained results of one of the used monitoring techniques, the crevice corrosion measurements obtained by the LOCOR-Cell„§. The crevice corrosion cell was developed by FORCE Technology in a previous district heating project financed by Nordic Industrial Fund (1)(2). Results from...... in 6 pressurised circulating heating systems and in one cooling system. 7 different corrosion monitoring methods have been used to study corrosion rates and types in dependency of water chemistry. This paper describes the design of the by-pass unit including water analysis methods. It also describes...... other used corrosion monitoring methods in the project are described elsewhere (3) and (4). For future district heating corrosion monitoring the by-pass unit can be recommended for permanent installation and the two methods high sensitive ER-technique (Metricorr) and the LOCOR-Cell„§ (FORCE Technology...

  13. Development of a unit suitable for corrosion monitoring in district heating systems. Experiences with the LOCOR-cell test method

    DEFF Research Database (Denmark)

    Andersen, Asbjørn; Hilbert, Lisbeth Rischel

    2004-01-01

    the purpose, background and gained results of one of the used monitoring techniques, the crevice corrosion measurements obtained by the LOCOR-Cell„§. The crevice corrosion cell was developed by FORCE Technology in a previous district heating project financed by Nordic Industrial Fund (1)(2). Results from...... in 6 pressurised circulating heating systems and in one cooling system. 7 different corrosion monitoring methods have been used to study corrosion rates and types in dependency of water chemistry. This paper describes the design of the by-pass unit including water analysis methods. It also describes...... other used corrosion monitoring methods in the project are described elsewhere (3) and (4). For future district heating corrosion monitoring the by-pass unit can be recommended for permanent installation and the two methods high sensitive ER-technique (Metricorr) and the LOCOR-Cell„§ (FORCE Technology...

  14. Hand disinfection in a neonatal intensive care unit: continuous electronic monitoring over a one-year period

    OpenAIRE

    Helder Onno K; van Goudoever Johannes B; Hop Wim C J; Brug Johannes; Kornelisse René F

    2012-01-01

    Abstract Background Good hand hygiene compliance is essential to prevent nosocomial infections in healthcare settings. Direct observation of hand hygiene compliance is the gold standard but is time consuming. An electronic dispenser with built-in wireless recording equipment allows continuous monitoring of its usage. The purpose of this study was to monitor the use of alcohol-based hand rub dispensers with a built-in electronic counter in a neonatal intensive care unit (NICU) setting and to d...

  15. Ozone monitoring in the UK (United Kingdom): A review of 1978/8. Data from monitoring sites operated by Warren Spring Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Bower, J.S.; Broughton, G.F.; Dando, M.T.

    1988-01-01

    A new national air-quality monitoring network has been established for the Department of the Environment. Its purpose is to determine rural baseline concentrations of ozone and other pollutants throughout the United Kingdom. The report describes the background to the establishment of the network, together with its present structure and instrumentation. A series of data analyses are presented and discussed, with the intention of providing a broad and preliminary overview of ozone observations at WSL-operated monitoring sites throughout the first full year of network operation. Average and peak levels of ozone during 1987/8 are quantified, seasonal and diurnal variations are determined, and high pollution periods are examined.

  16. Evaluating and monitoring analgesia and sedation in the intensive care unit.

    Science.gov (United States)

    Sessler, Curtis N; Grap, Mary Jo; Ramsay, Michael Ae

    2008-01-01

    Management of analgesia and sedation in the intensive care unit requires evaluation and monitoring of key parameters in order to detect and quantify pain and agitation, and to quantify sedation. The routine use of subjective scales for pain, agitation, and sedation promotes more effective management, including patient-focused titration of medications to specific end-points. The need for frequent measurement reflects the dynamic nature of pain, agitation, and sedation, which change constantly in critically ill patients. Further, close monitoring promotes repeated evaluation of response to therapy, thus helping to avoid over-sedation and to eliminate pain and agitation. Pain assessment tools include self-report (often using a numeric pain scale) for communicative patients and pain scales that incorporate observed behaviors and physiologic measures for noncommunicative patients. Some of these tools have undergone validity testing but more work is needed. Sedation-agitation scales can be used to identify and quantify agitation, and to grade the depth of sedation. Some scales incorporate a step-wise assessment of response to increasingly noxious stimuli and a brief assessment of cognition to define levels of consciousness; these tools can often be quickly performed and easily recalled. Many of the sedation-agitation scales have been extensively tested for inter-rater reliability and validated against a variety of parameters. Objective measurement of indicators of consciousness and brain function, such as with processed electroencephalography signals, holds considerable promise, but has not achieved widespread implementation. Further clarification of the roles of these tools, particularly within the context of patient safety, is needed, as is further technology development to eliminate artifacts and investigation to demonstrate added value.

  17. A New Model of Delirium Care in the Acute Geriatric Setting: Geriatric Monitoring Unit

    Directory of Open Access Journals (Sweden)

    Chong Mei

    2011-08-01

    Full Text Available Abstract Background Delirium is a common and serious condition, which affects many of our older hospitalised patients. It is an indicator of severe underlying illness and requires early diagnosis and prompt treatment, associated with poor survival, functional outcomes with increased risk of institutionalisation following the delirium episode in the acute care setting. We describe a new model of delirium care in the acute care setting, titled Geriatric Monitoring Unit (GMU where the important concepts of delirium prevention and management are integrated. We hypothesize that patients with delirium admitted to the GMU would have better clinical outcomes with less need for physical and psychotropic restraints compared to usual care. Methods/Design GMU models after the Delirium Room with adoption of core interventions from Hospital Elder Life Program and use of evening bright light therapy to consolidate circadian rhythm and improve sleep in the elderly patients. The novelty of this approach lies in the amalgamation of these interventions in a multi-faceted approach in acute delirium management. GMU development thus consists of key considerations for room design and resource planning, program specific interventions and daily core interventions. Assessments undertaken include baseline demographics, comorbidity scoring, duration and severity of delirium, cognitive, functional measures at baseline, 6 months and 12 months later. Additionally we also analysed the pre and post-GMU implementation knowledge and attitude on delirium care among staff members in the geriatric wards (nurses, doctors and undertook satisfaction surveys for caregivers of patients treated in GMU. Discussion This study protocol describes the conceptualization and implementation of a specialized unit for delirium management. We hypothesize that such a model of care will not only result in better clinical outcomes for the elderly patient with delirium compared to usual geriatric care

  18. Admitting acute ischemic stroke patients to a stroke care monitoring unit versus a conventional stroke unit : a randomized pilot study

    NARCIS (Netherlands)

    Sulter, Geert; Elting, Jan Willem; Langedijk, Marc; Maurits, Natasha M; De Keyser, Jacques

    2003-01-01

    BACKGROUND AND PURPOSE: Pathophysiological considerations and observational studies indicate that elevated body temperature, hypoxia, hypotension, and cardiac arrhythmias in the acute phase of ischemic stroke may aggravate brain damage and worsen outcome. METHODS: Both units were organized with the

  19. Admitting acute ischemic stroke patients to a stroke care monitoring unit versus a conventional stroke unit : a randomized pilot study

    NARCIS (Netherlands)

    Sulter, Geert; Elting, Jan Willem; Langedijk, Marc; Maurits, Natasha M; De Keyser, Jacques

    2003-01-01

    BACKGROUND AND PURPOSE: Pathophysiological considerations and observational studies indicate that elevated body temperature, hypoxia, hypotension, and cardiac arrhythmias in the acute phase of ischemic stroke may aggravate brain damage and worsen outcome. METHODS: Both units were organized with the

  20. MOTOR UNIT TERRITORIES AND FIBER TYPES IN RABBIT MASSETER MUSCLE

    NARCIS (Netherlands)

    WEIJS, WA; JUCH, PJW; KWA, SHS; KORFAGE, JAM

    1993-01-01

    The myosin heavy chain (MHC) content and spatial distribution of the fibers of 11 motor units (MUs) of the rabbit masseter muscle were determined. The fibers of single MUs were visualized in whole-muscle serial sections by a negative periodic acid/Schiff reaction for glycogen after they had been dep

  1. The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism.

    Science.gov (United States)

    Gaillard, Pierre-Henri L; Noguchi, Eishi; Shanahan, Paul; Russell, Paul

    2003-09-01

    Functional studies strongly suggest that the Mus81-Eme1 complex resolves Holliday junctions (HJs) in fission yeast, but in vitro it preferentially cleaves flexible three-way branched structures that model replication forks or 3' flaps. Here we report that a nicked HJ is the preferred substrate of endogenous and recombinant Mus81-Eme1. Cleavage occurs specifically on the strand that opposes the nick, resulting in resolution of the structure into linear duplex products. Resolving cuts made by the endogenous Mus81-Eme1 complex on an intact HJ are quasi-simultaneous, indicating that Mus81-Eme1 resolves HJs by a nick and counternick mechanism, with a large rate enhancement of the second cut arising from the flexible nature of the nicked HJ intermediate. Recombinant Mus81-Eme1 is ineffective at making the first cut. We also report that HJs accumulate in a DNA polymerase alpha mutant that lacks Mus81, providing further evidence that the Mus81-Eme1 complex targets HJs in vivo.

  2. MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis.

    Directory of Open Access Journals (Sweden)

    J Kim Holloway

    2008-09-01

    Full Text Available Two eukaryotic pathways for processing double-strand breaks (DSBs as crossovers have been described, one dependent on the MutL homologs Mlh1 and Mlh3, and the other on the structure-specific endonuclease Mus81. Mammalian MUS81 has been implicated in maintenance of genomic stability in somatic cells; however, little is known about its role during meiosis. Mus81-deficient mice were originally reported as being viable and fertile, with normal meiotic progression; however, a more detailed examination of meiotic progression in Mus81-null animals and WT controls reveals significant meiotic defects in the mutants. These include smaller testis size, a depletion of mature epididymal sperm, significantly upregulated accumulation of MLH1 on chromosomes from pachytene meiocytes in an interference-independent fashion, and a subset of meiotic DSBs that fail to be repaired. Interestingly, chiasmata numbers in spermatocytes from Mus81-/- animals are normal, suggesting additional integrated mechanisms controlling the two distinct crossover pathways. This study is the first in-depth analysis of meiotic progression in Mus81-nullizygous mice, and our results implicate the MUS81 pathway as a regulator of crossover frequency and placement in mammals.

  3. [Predictive variables for mental retardation in a Pediatric Epilepsy Monitoring Unit. Neuropsychological assessment].

    Science.gov (United States)

    López-Sala, A; Palacio-Navarro, A; Donaire, A; García, G; Colomé, R; Boix, C; Sans, A; Campistol, J; Sanmartí, F X

    2010-03-03

    We sought to describe the epidemiological and clinical data from our patients in the Pediatric Epilepsy Monitoring Unit (PEMU) of the Sant Joan de Deu Hospital of Barcelona, and determine the variables of risk for mental retardation. A retrospective review of PEMU reports and hospital discharge summaries from March 2005 to December 2008 was conducted. The data from patients with intelligence quotient (IQ) estimated, older than 3 years of age and with epileptic electroencephalography (EEG) activity was analyzed in 158 patients (8.8 +/- 5.2 years; 55.1% boys). Of those pediatric patients, 63 had IQ less than 70 and 47 an IQ greater than or equal to 70. Intractable epilepsy was present in all of them. The percentage of the patients with mental retardation is significantly higher in patients with onset of epilepsy before 24 months (68.3%) than patients with later onset (27.7%). Onset of seizures, EEG findings and epilepsy etiology are significant risk factors for mental retardation. Early age at seizure, multifocal epilepsy and cryptogenic etiology are factors of worse prognosis to normal development of cognitive functions in pediatric intractable epilepsy.

  4. ON-BOARD MONITORING OF TECHNICAL STATE FOR POWER UNITS OF WHEELED AND TRACKED VEHICLES

    Directory of Open Access Journals (Sweden)

    Yu. D. Karpievich

    2016-01-01

    Full Text Available The paper considers new methodologies pertaining to on-board diagnosis of wear-out rate for friction linings of a clutch driven disk and friction discs of a hydraulic press clutch of transmission gear boxes which are based on physical process that uses friction work as an integrated indicator. A new methodology in determination of life-span rate for engine oil has been developed in the paper. The paper presents block schematic diagrams for on-board monitoring of technical state for power units of wheeled and tracked vehicles. Usage of friction work as an integrated indicator for determination of wear-out rate for friction linings of clutch driven disk and friction discs of a haydraulic press clutch makes it possible timely at any operational period of wheeled and tracked vehicles to determine their residual operation life and forecast their replacement.While taking volume of the used fuel for determination of engine oil life-span rate it permits quickly and effectively at any operational period of wheeled and tracked vehicles to determine residual useful life of the engine oil and also forecast its replacement.

  5. The influence of impression management scales on the Personality Assessment Inventory in the epilepsy monitoring unit.

    Science.gov (United States)

    Purdom, Catherine L; Kirlin, Kristin A; Hoerth, Matthew T; Noe, Katherine H; Drazkowski, Joseph F; Sirven, Joseph I; Locke, Dona E C

    2012-12-01

    The Somatic Complaints scale (SOM) and Conversion subscale (SOM-C) of the Personality Assessment Inventory perform best in classifying psychogenic non-epileptic seizures (PNES) from epileptic seizures (ES); however, the impact of positive impression management (PIM) and negative impression management (NIM) scales on SOM and SOM-C classification has not been examined. We studied 187 patients from an epilepsy monitoring unit with confirmed PNES or ES. On SOM, the best cut score was 72.5 T when PIM was elevated and 69.5 T when there was no bias. On SOM-C, when PIM was elevated, the best cut score was 67.5 T and 76.5 T when there was no bias. Negative impression management elevations (n=9) were too infrequent to analyze separately. Despite similarities in classification accuracy, there were differences in sensitivity and specificity with and without PIM, impacting positive and negative predictive values. The presence of PIM bias generally increases positive predictive power of SOM and SOM-C but decreases negative predictive power.

  6. An Improved Calibration Method for Hydrazine Monitors for the United States Air Force

    Energy Technology Data Exchange (ETDEWEB)

    Korsah, K

    2003-07-07

    This report documents the results of Phase 1 of the ''Air Force Hydrazine Detector Characterization and Calibration Project''. A method for calibrating model MDA 7100 hydrazine detectors in the United States Air Force (AF) inventory has been developed. The calibration system consists of a Kintek 491 reference gas generation system, a humidifier/mixer system which combines the dry reference hydrazine gas with humidified diluent or carrier gas to generate the required humidified reference for calibrations, and a gas sampling interface. The Kintek reference gas generation system itself is periodically calibrated using an ORNL-constructed coulometric titration system to verify the hydrazine concentration of the sample atmosphere in the interface module. The Kintek reference gas is then used to calibrate the hydrazine monitors. Thus, coulometric titration is only used to periodically assess the performance of the Kintek reference gas generation system, and is not required for hydrazine monitor calibrations. One advantage of using coulometric titration for verifying the concentration of the reference gas is that it is a primary standard (if used for simple solutions), thereby guaranteeing, in principle, that measurements will be traceable to SI units (i.e., to the mole). The effect of humidity of the reference gas was characterized by using the results of concentrations determined by coulometric titration to develop a humidity correction graph for the Kintek 491 reference gas generation system. Using this calibration method, calibration uncertainty has been reduced by 50% compared to the current method used to calibrate hydrazine monitors in the Air Force inventory and calibration time has also been reduced by more than 20%. Significant findings from studies documented in this report are the following: (1) The Kintek 491 reference gas generation system (generator, humidifier and interface module) can be used to calibrate hydrazine detectors. (2) The

  7. GAMBARAN HEMATOLOGI MENCIT (Mus musculus MODEL TOKSISITAS SUBKRONIS

    Directory of Open Access Journals (Sweden)

    Ita Nur Eka Pujiastuti

    2017-06-01

    Full Text Available Garlic commonly is consumed as medicine to prevent or heal illness or to maintain someone's health. Many societies prefer garlic (Allium sativum among other herbal remedies for cholesterol treatment. It consists of several types, and one of them is single bulb garlic used to treat hypertension. There has been, however, no published research reporting the toxicological properties of single bulb garlic. The purpose of this study was to determine subchronic toxic effects of single bulb garlic administered to mice using hematological parameters. The experiment parameters were hemoglobin and hematocrit levels, the number of erythrocytes and leukocytes. Male mice (Mus musculus strain Balb-C were treated with single bulb garlic extract for 28 days with dosage levels of 0% (N , 0.25% (P1 , 0.5% (P2 , 1% (P3 , and 2% (P4 . Single bulb garlic showed no effect on hemoglobin and hematocrit levels but increased the number of erythrocyte and leucocyte. We concluded that single bulb garlic did not cause subchronic toxic effects.

  8. Regional monitoring programs in the United States: Synthesis of four case studies from Pacific, Atlantic, and Gulf Coasts

    Science.gov (United States)

    Tango, Peter J.; Schiff, K.; Trowbridge, P.R.; Sherwood, E.T.; Batiuk, R.A.

    2016-01-01

    Water quality monitoring is a cornerstone of environmental protection and ambient monitoring provides managers with the critical data they need to take informed action. Unlike site-specific monitoring that is at the heart of regulatory permit compliance, regional monitoring can provide an integrated, holistic view of the environment, allowing managers to obtain a more complete picture of natural variability and cumulative impacts, and more effectively prioritize management actions. By reviewing four long-standing regional monitoring programs that cover portions of all three coasts in the United States – Chesapeake Bay, Tampa Bay, Southern California Bight, and San Francisco Bay – important insights can be gleaned about the benefits that regional monitoring provides to managers. These insights include the underlying reasons that make regional monitoring programs successful, the challenges to maintain relevance and viability in the face of ever-changing technology, competing demands and shifting management priorities. The lessons learned can help other managers achieve similar successes as they seek to establish and reinvigorate their own monitoring programs.

  9. Continuous ‘Passive’ flow-proportional monitoring of drainage using a new modified Sutro weir (MSW) unit

    DEFF Research Database (Denmark)

    Vendelboe, Anders Lindblad; Rozemeijer, Joachim; de Jonge, Lis Wollesen;

    2016-01-01

    In view of their crucial role in water and solute transport, enhanced monitoring of agricultural subsurface drain tile systems is important for adequate water quality management. However, existing monitoring techniques for flow and contaminant loads from tile drains are expensive and labour...... information for the selection and evaluation of mitigation options to improve water quality.Results from this type of monitoring can provide data for the evaluation and optimisation of best management practices in agriculture in order to produce the highest yield without water quality and recipient surface...... intensive. The aim of this study was to develop a cost-effective and simple method for monitoring loads from tile drains. The Flowcap is a modified Sutro weir (MSW) unit that canbe attached to the outlet of tile drains. It is capable of registering total flow, contaminant loads and flowaveraged...

  10. DUCKS: Low cost thermal monitoring units for near-vent deployment

    Science.gov (United States)

    Harris, A.; Pirie, D.; Horton, K.; Garbeil, H.; Pilger, E.; Ramm, H.; Hoblitt, R.; Thornber, C.; Ripepe, M.; Marchetti, E.; Poggi, P.

    2005-01-01

    During 1999 we designed and tested a thermal monitoring system to provide a cheap, robust, modular, real-time system capable of surviving the hostile conditions encountered proximal to active volcanic vents. In November 2000 the first system was deployed at Pu'u 'O'o (Kilauea, Hawai'i) to target persistently active vents. Aside from some minor problems, such as sensor damage due to tampering, this system remained operational until January 2004. The success of the prototype system led us to use the blueprint for a second installation at Stromboli (Aeolian Islands, Italy). This was deployed, dug into a bomb-proof bunker, during May 2002 and survived the April 2003 paroxysmal eruption despite being located just 250 m from the vent. In both cases, careful waterproofing of connectors and selection of suitable protection has prevented water damage and corrosion in the harsh atmosphere encountered at the crater rim. The Pu'u 'O'o system cost ???US$10,000 and comprises four modules: sensors, transmission and power hub, repeater station and reception site. The sensor component consists of three thermal infrared thermometers housed in Pelican??? cases fitted with Germanium-Arsenide-Selenium windows. Two 1?? field of view (FOV) sensors allow specific vents to be targeted and a 60?? FOV sensor provides a crater floor overview. A hard wire connection links to a Pelican???-case-housed microprocessor, modem and power module. From here data are transmitted, via a repeater site, to a dedicated PC at the Hawaiian Volcano Observatory. Here data are displayed with a delay of ???3 s between acquisition and display. The modular design allows for great flexibility. At Stromboli, 1?? and 15?? FOV sensor modules can be switched depending changes in activity style and crater geometry. In addition a direct line of site to the Stromboli reception center negates the repeater site requirement, reducing the cost to US$5500 for a single sensor system. We have also constructed self-contained units

  11. Environmental Monitoring Plan, United States Department of Energy, Richland Operations Office. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    1994-11-09

    This report describes environmental monitoring activities at Hanford Reservation. Attention is focused on effluent monitoring and environmental surveillance. All Hanford contractors reviewed potential sources of contamination. A facility effluent monitoring plan was written for each facility with the potential to release significant quantities of hazardous materials, addressing both radiological and nonradiological effluent monitoring. The environmental surveillance program assesses onsite and offsite environmental impacts and offsite human health exposures. The program monitors air, surface water, sediment, agricultural products, vegetation, soil, and wildlife. In addition, independent onsite surveillance is conducted to evaluate the effectiveness of Hanford Site effluent controls in order to comply with applicable environmental standards and regulations.

  12. Electroencephalographic Patterns Recorded by Continuous EEG Monitoring in Patients with Change of Consciousness in the Neurological Intensive Care Unit.

    Science.gov (United States)

    Altindağ, Ebru; Okudan, Zeynep Vildan; Tavukçu Özkan, Sedef; Krespi, Yakup; Baykan, Betül

    2017-06-01

    Our aim was to examine the frequency of various electrographic patterns including periodic discharges (PD), repetitive spike waves (RSW), rhythmic delta activities (RDA), nonconvulsive seizures (NCS) and nonconvulsive status epilepticus (NCSE) in continuous EEG monitoring (cEEG) of the critically ill patients with change of consciousness and the presence of specific clinical and laboratory findings associated with these important patterns in this study. Patients with changes of consciousness in the neurological intensive care unit (NICU) were consecutively monitored with cEEG during 2 years. Their clinical, electrophysiological, radiological and laboratory findings were evaluated retrospectively. This sample consisted of 57 (25 men) patients with a mean age of 68.2 years. Mean duration of cEEG monitoring was 2532.6 minutes. The most common electrographic patterns were PD (33%) and NCS-NCSE (26.3%). The presence of NCS-NCSE was significantly associated with PD (57.9%, p<0.001). PD and NCS-NCSE were the mostly seen in patients with acute stroke and hypoxic encephalopathy. Duration of monitoring was significantly longer in the group with PD and NCS-NCSE (p:0.004, p:0.014). Detection of any electrographic pattern in EEG before monitoring was associated with the presence of any pattern in cEEG (59.3%, p<0.0001). Convulsive or nonconvulsive seizure during monitoring was common in patients with electrographic patterns (p<0.0001). 66.7% of NCS-NCSE was seen within the first 12 hours and 26.7% was seen within the 12-24 hours of the monitoring. Detection of any electrographic pattern in EEG before monitoring was associated with the presence of any important pattern in cEEG monitoring. This association suggest that at least 24 hours-monitoring of these patients could be useful for the diagnosis of clinical and/or electrographic seizures.

  13. Molecular mass spectrometric identification of superoxide dismutase in the liver of mice Mus musculus and Mus spretus using a metallomics analytical approach.

    Science.gov (United States)

    González-Fernández, M; García-Barrera, T; Gómez-Ariza, J L

    2011-11-01

    This paper reports the identification and quantification of superoxide dismutase in the liver of Mus musculus and Mus spretus mice using a metallomics analytical approach. The approach consisted of using orthogonal chromatographic systems coupled to ICP-MS and UV detectors. Size-exclusion fractionation of the cytosolic extracts was followed by anion-exchange chromatographic separation of Cu- and Zn-containing species. After purification then tryptic digestion, Cu- and Zn-containing superoxide dismutase was identified by nESI-QqTOF. The MS-MS spectra of doubly charged peptides, with the Mascot searching engine, were used to obtain the sequence of the protein.

  14. Strategies for Monitoring Outcomes in HIV-Exposed Uninfected Children in the United Kingdom.

    Science.gov (United States)

    Thorne, Claire; Tookey, Pat

    2016-01-01

    Surveillance of pregnancies in women living with HIV is carried out on a national basis in the United Kingdom (UK) through the National Study of HIV in Pregnancy and Childhood. There are currently around 1100-1200 HIV-exposed uninfected (HEU) infants born every year in the UK, where vertical transmission of HIV now occurs in fewer than 5 in every 1000 pregnancies. By the end of 2014, there was a cumulative total of more than 15,000 HEU children with any combination antiretroviral therapy (cART) exposure and more than 5000 with cART exposure from conception in the UK. HEU infants are increasingly being exposed to newer antiretroviral drugs for which less is known regarding both short- and long-term safety. In this commentary, we describe the approaches that have been taken to explore health outcomes in HEU children born in the UK. This includes the Children exposed to AntiRetroviral Therapy (CHART) Study, which was a consented follow-up study carried out in 2002-2005 of HEU children born in 1996-2004. The CHART Study showed that 4% of HEU children enrolled had a major health or development problem in early childhood; this was within expected UK norms, but the study was limited by small numbers and short-term follow-up. However, the problems with recruitment and retention that were encountered within the CHART Study demonstrated that comprehensive, clinic-based follow-up was not a feasible approach for long-term assessment of HEU children in the UK. We describe an alternative approach developed to monitor some aspects of their long-term health, involving the "flagging" of HEU infants for death and cancer registration with the UK Office for National Statistics. Some of the ethical concerns regarding investigation of long-term outcomes of in utero and perinatal exposure to antiretrovirals, including those relating to consent and confidentiality, are also discussed.

  15. Strategies for monitoring outcomes in HIV-exposed uninfected children in the United Kingdom

    Directory of Open Access Journals (Sweden)

    Claire eThorne

    2016-05-01

    Full Text Available Surveillance of pregnancies in women living with HIV is carried out on a national basis in the United Kingdom (UK through the National Study of HIV in Pregnancy and Childhood (NSHPC. There are currently around 1100-1200 HIV-exposed uninfected (HEU infants born every year in the UK, where vertical transmission of HIV now occurs in fewer than five in every 1000 pregnancies. By the end of 2014, there was a cumulative total of more than 15,000 HEU children with any combination antiretroviral therapy (cART exposure and more than 5,000 with cART exposure from conception in the UK. HEU infants are increasingly being exposed to newer antiretroviral drugs for which less is known regarding both short and longer-term safety. In this commentary, we describe the approaches that have been taken to explore health outcomes in HEU children born in the UK. This includes the Children exposed to AntiRetroviral Therapy (CHART Study, which was a consented follow-up study carried out in 2002-2005 of HEU children born in 1996-2004. The CHART Study showed that 4% of HEU children enrolled had a major health or development problem in early childhood; this was within expected UK norms but the study was limited by small numbers and short-term follow-up. However, the problems with recruitment and retention that were encountered within the CHART Study demonstrated that comprehensive, clinic-based follow-up was not a feasible approach for long-term assessment of HEU children in the UK. We describe an alternative approach developed to monitor some aspects of their long-term health, involving the flagging of HEU infants for death and cancer registration with the UK Office for National Statistics. Some of the ethical concerns regarding investigation of long-term outcomes of in utero and perinatal exposure to antiretrovirals including those relating to consent and confidentiality are also discussed.

  16. Monitoring the status of forests and rangelands in the Western United States using ecosystem performance anomalies

    Science.gov (United States)

    Rigge, Matthew B.; Wylie, Bruce; Gu, Yingxin; Belnap, Jayne; Phuyal, Khem P.; Tieszen, Larry

    2013-01-01

    The effects of land management and disturbance on ecosystem performance (i.e. biomass production) are often confounded by those of weather and site potential. The current study overcomes this issue by calculating the difference between actual and expected ecosystem performance (EEP) to generate ecosystem performance anomalies (EPA). This study aims to delineate and quantify average EPA from 2000–2009 within the Greater Platte and Upper Colorado River Basins, USA. Moderate Resolution Imaging Spectroradiometer (MODIS) normalized difference vegetation index (NDVI) images averaged over the growing season (GSN) served as a proxy of actual ecosystem performance. Yearly EEP was determined with rule-based piecewise regression tree models of abiotic data (climate, soils, elevation, etc.), independently created for each land cover. EPA were calculated as the residuals of the EEP to GSN relationship, and characterized as normal performing, underperforming, and overperforming at the 90% confidence level. Validation revealed that EPA values were related to biomass production (R2 = 0.56, P = 0.02) and likely to the proportion of biomass removed by livestock in the Nebraska Sandhills. Overall, 60.6% of the study area was (normal) performing near its EEP, 3.0% was severely underperforming, 5.0% was highly overperforming, and the remainder was slightly underperforming or overperforming. Generally, disturbances such as fires, floods, and insect damage, in addition to high grazing intensity, result in a negative EPA. Conversely, mature stands and appropriate management often result in positive EPA values. This method provides information critical to land managers to evaluate the appropriateness of previous management practices and restoration efforts and quantify disturbance impacts. Results are at a scale sufficient for many of the large management units of the region and for locating areas needing further investigation. Applications of EPA data to monitoring invasive species

  17. Motor unit recruitment pattern during low-level static and dynamic contractions.

    Science.gov (United States)

    Søgaard, K

    1995-03-01

    Motor unit (MU) recruitment patterns were studied during dynamic and static contractions at workloads corresponding to 10% of maximal voluntary contraction force. The dynamic contraction consisted of a 20 degrees flexion and extension of the elbow performed with a velocity of 10 degrees/s. Motor unit potential trains were recorded from the brachial biceps muscle of 6 healthy females using a quadripolar needle electrode and a computerized decomposition program. Properties of the identified MUs were derived from concentric needle EMG. A total of 119 MUs were identified during dynamic contractions, 107 MUs during static anisotonic contractions, and 96 MUs during static isotonic contractions. The main result was that MUs recruited during different contractions showed similar properties and may belong to the same part of the motoneuron pool. This indicates that MU recruitment patterns during dynamic contractions may be almost as stereotypical as during static contractions and may even activate the same MUs.

  18. Médiation documentaire et culturelle dans le musée

    OpenAIRE

    Fabre, Isabelle

    2012-01-01

    International audience; L’article propose de comprendre la place occupée par la médiation documentaire dans le musée où s’exerce une médiation plutôt qualifiée de culturelle. Nous avons choisi de travailler suivant une méthode qualitative, en analysant les discours des documentalistes, qu’ils soient oraux ou écrits, recueillis dans le contexte particulier du musée des Abattoirs, musée d’art contemporain de Toulouse. La médiation documentaire dans le musée, s’oriente aujourd’hui vers la mise e...

  19. MusE GAs FLOw and Wind (MEGAFLOW) I: First MUSE results on background quasars

    CERN Document Server

    Schroetter, Ilane; Wendt, Martin; Contini, Thierry; Finley, Hayley; Pello, Roser; Bacon, Roland; Cantalupo, Sebastiano; Marino, Raffaella; Richard, Johan; Lilly, Simon; Schaye, Joop; Soto, Kurt; Steinmetz, Matthias; Straka, Lorrie A; Wisotzki, Lutz

    2016-01-01

    The physical properties of galactic winds are one of the keys to understand galaxy formation and evolution. These properties can be constrained thanks to background quasar lines of sight (LOS) passing near star-forming galaxies (SFGs). We present the first results of the MusE GAs FLOw and Wind (MEGAFLOW) survey obtained of 2 quasar fields which have 8 MgII absorbers of which 3 have rest-equivalent width greater than 0.8 \\AA. With the new Multi Unit Spectroscopic Explorer (MUSE) spectrograph on the Very Large Telescope (VLT), we detect 6 (75$\\%$) MgII host galaxy candidates withing a radius of 30 arcsec from the quasar LOS. Out of these 6 galaxy--quasar pairs, from geometrical arguments, one is likely probing galactic outflows, two are classified as "ambiguous", two are likely probing extended gaseous disks and one pair seems to be a merger. We focus on the wind$-$pair and constrain the outflow using a high resolution quasar spectra from Ultraviolet and Visual Echelle Spectrograph (UVES). Assuming the metal ab...

  20. Design of a microprocessor-based Control, Interface and Monitoring (CIM unit for turbine engine controls research

    Science.gov (United States)

    Delaat, J. C.; Soeder, J. F.

    1983-01-01

    High speed minicomputers were used in the past to implement advanced digital control algorithms for turbine engines. These minicomputers are typically large and expensive. It is desirable for a number of reasons to use microprocessor-based systems for future controls research. They are relatively compact, inexpensive, and are representative of the hardware that would be used for actual engine-mounted controls. The Control, Interface, and Monitoring Unit (CIM) contains a microprocessor-based controls computer, necessary interface hardware and a system to monitor while it is running an engine. It is presently being used to evaluate an advanced turbofan engine control algorithm.

  1. Two Distinct MUS81-EME1 Complexes from Arabidopsis Process Holliday Junctions1[W

    Science.gov (United States)

    Geuting, Verena; Kobbe, Daniela; Hartung, Frank; Dürr, Jasmin; Focke, Manfred; Puchta, Holger

    2009-01-01

    The MUS81 endonuclease complex has been shown to play an important role in the repair of stalled or blocked replication forks and in the processing of meiotic recombination intermediates from yeast to humans. This endonuclease is composed of two subunits, MUS81 and EME1. Surprisingly, unlike other organisms, Arabidopsis (Arabidopsis thaliana) has two EME1 homologs encoded in its genome. AtEME1A and AtEME1B show 63% identity on the protein level. We were able to demonstrate that, after expression in Escherichia coli, each EME1 protein can assemble with the unique AtMUS81 to form a functional endonuclease. Both complexes, AtMUS81-AtEME1A and AtMUS81-AtEME1B, are not only able to cleave 3′-flap structures and nicked Holliday junctions (HJs) but also, with reduced efficiency, intact HJs. While the complexes have the same cleavage patterns with both nicked DNA substrates, slight differences in the processing of intact HJs can be detected. Our results are in line with an involvement of both MUS81-EME1 endonuclease complexes in DNA recombination and repair processes in Arabidopsis. PMID:19339504

  2. Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates?

    Science.gov (United States)

    Gaskell, Louise J; Osman, Fekret; Gilbert, Robert J C; Whitby, Matthew C

    2007-04-04

    The Holliday junction (HJ) is a central intermediate of homologous recombination. Its cleavage is critical for the formation of crossover recombinants during meiosis, which in turn helps to establish chiasmata and promote genetic diversity. Enzymes that cleave HJs, called HJ resolvases, have been identified in all domains of life except eukaryotic nuclei. Controversially, the Mus81-Eme1 endonuclease has been proposed to be an example of a eukaryotic nuclear resolvase. However, hitherto little or no HJ cleavage has been detected in recombinant preparations of Mus81-Eme1. Here, we report the purification of active forms of recombinant Schizosaccharomyces pombe Mus81-Eme1 and Saccharomyces cerevisiae Mus81-Mms4, which display robust HJ cleavage in vitro, which, in the case of Mus81-Eme1, is as good as the archetypal HJ resolvase RuvC in single turnover kinetic analysis. We also present genetic evidence that suggests that this activity might be utilised as a back-up to Mus81-Eme1's main activity of cleaving nicked HJs during meiosis in S. pombe.

  3. Two distinct MUS81-EME1 complexes from Arabidopsis process Holliday junctions.

    Science.gov (United States)

    Geuting, Verena; Kobbe, Daniela; Hartung, Frank; Dürr, Jasmin; Focke, Manfred; Puchta, Holger

    2009-06-01

    The MUS81 endonuclease complex has been shown to play an important role in the repair of stalled or blocked replication forks and in the processing of meiotic recombination intermediates from yeast to humans. This endonuclease is composed of two subunits, MUS81 and EME1. Surprisingly, unlike other organisms, Arabidopsis (Arabidopsis thaliana) has two EME1 homologs encoded in its genome. AtEME1A and AtEME1B show 63% identity on the protein level. We were able to demonstrate that, after expression in Escherichia coli, each EME1 protein can assemble with the unique AtMUS81 to form a functional endonuclease. Both complexes, AtMUS81-AtEME1A and AtMUS81-AtEME1B, are not only able to cleave 3'-flap structures and nicked Holliday junctions (HJs) but also, with reduced efficiency, intact HJs. While the complexes have the same cleavage patterns with both nicked DNA substrates, slight differences in the processing of intact HJs can be detected. Our results are in line with an involvement of both MUS81-EME1 endonuclease complexes in DNA recombination and repair processes in Arabidopsis.

  4. Mus308 Processes Oxygen and Nitrogen Ethylation DNA Damage in Germ Cells of Drosophila

    Directory of Open Access Journals (Sweden)

    Nancy Díaz-Valdés

    2010-01-01

    Full Text Available The D. melanogaster mus308 gene, highly conserved among higher eukaryotes, is implicated in the repair of cross-links and of O-ethylpyrimidine DNA damage, working in a DNA damage tolerance mechanism. However, despite its relevance, its possible role on the processing of different DNA ethylation damages is not clear. To obtain data on mutation frequency and on mutation spectra in mus308 deficient (mus308- conditions, the ethylating agent diethyl sulfate (DES was analysed in postmeiotic male germ cells. These data were compared with those corresponding to mus308 efficient conditions. Our results indicate that Mus308 is necessary for the processing of oxygen and N-ethylation damage, for the survival of fertilized eggs depending on the level of induced DNA damage, and for an influence of the DNA damage neighbouring sequence. These results support the role of mus308 in a tolerance mechanism linked to a translesion synthesis pathway and also to the alternative end-joinig system.

  5. Post-Closure Inspection and Monitoring Report for Corrective Action Unit 110: Area 3 WMD U-3ax/bl Crater, Nevada Test Site, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Bechtel Nevada

    2006-08-01

    This Post-Closure Inspection and Monitoring Report provides the results and inspections and monitoring for Corrective Action Unit 110: Area 3 Waste Management Division U-3ax/bl Crater, Nevada Test Site, Nevada. This report includes an analysis and summary of the site inpsections, repairs and maintenance, meteorological information, and soil moisture monitoring data obtained at Corrective Action Unit 110, for the annual period July 2005 thrugh June 2006.

  6. Automatic chemical monitoring in the composition of functions performed by the unit level control system in the new projects of nuclear power plant units

    Science.gov (United States)

    Denisova, L. G.; Khrennikov, N. N.

    2014-08-01

    The article presents information on the state of regulatory framework and development of a subsystem for automated chemical monitoring of water chemistries in the primary and secondary coolant circuits used as part of the automatic process control system in new projects of VVER reactor-based nuclear power plant units. For the strategy of developing and putting in use the water chemistry-related part of the automated process control system within the standard AES-2006 nuclear power plant project to be implemented, it is necessary to develop regulatory documents dealing with certain requirements imposed on automatic water chemistry monitoring systems in accordance with the requirements of federal codes and regulations in the field of using atomic energy.

  7. The role of neuropsychology on an epilepsy monitoring unit: a peek behind the "do not disturb" sign.

    Science.gov (United States)

    Kirlin, Kristin A; Locke, Dona E C

    2014-09-01

    Neuropsychological services are considered an essential component of specialized epilepsy centers. In such a multidisciplinary setting, neuropsychologists interact regularly with other professionals involved in epilepsy patients' care. For these other professionals, this article provides an overview of the background of neuropsychologists, the services they provide, and how their findings contribute to the evaluation of the epilepsy patient. Two case examples are included to illustrate how neuropsychological evaluations are employed in the epilepsy monitoring unit setting.

  8. A Greedy reassignment algorithm for the PBS minimum monitor unit constraint

    Science.gov (United States)

    Lin, Yuting; Kooy, Hanne; Craft, David; Depauw, Nicolas; Flanz, Jacob; Clasie, Benjamin

    2016-06-01

    Proton pencil beam scanning (PBS) treatment plans are made of numerous unique spots of different weights. These weights are optimized by the treatment planning systems, and sometimes fall below the deliverable threshold set by the treatment delivery system. The purpose of this work is to investigate a Greedy reassignment algorithm to mitigate the effects of these low weight pencil beams. The algorithm is applied during post-processing to the optimized plan to generate deliverable plans for the treatment delivery system. The Greedy reassignment method developed in this work deletes the smallest weight spot in the entire field and reassigns its weight to its nearest neighbor(s) and repeats until all spots are above the minimum monitor unit (MU) constraint. Its performance was evaluated using plans collected from 190 patients (496 fields) treated at our facility. The Greedy reassignment method was compared against two other post-processing methods. The evaluation criteria was the γ-index pass rate that compares the pre-processed and post-processed dose distributions. A planning metric was developed to predict the impact of post-processing on treatment plans for various treatment planning, machine, and dose tolerance parameters. For fields with a pass rate of 90  ±  1% the planning metric has a standard deviation equal to 18% of the centroid value showing that the planning metric and γ-index pass rate are correlated for the Greedy reassignment algorithm. Using a 3rd order polynomial fit to the data, the Greedy reassignment method has 1.8 times better planning metric at 90% pass rate compared to other post-processing methods. As the planning metric and pass rate are correlated, the planning metric could provide an aid for implementing parameters during treatment planning, or even during facility design, in order to yield acceptable pass rates. More facilities are starting to implement PBS and some have spot sizes (one standard deviation) smaller than 5

  9. Effects of minimum monitor unit threshold on spot scanning proton plan quality.

    Science.gov (United States)

    Howard, Michelle; Beltran, Chris; Mayo, Charles S; Herman, Michael G

    2014-09-01

    To investigate the influence of the minimum monitor unit (MU) on the quality of clinical treatment plans for scanned proton therapy. Delivery system characteristics limit the minimum number of protons that can be delivered per spot, resulting in a min-MU limit. Plan quality can be impacted by the min-MU limit. Two sites were used to investigate the impact of min-MU on treatment plans: pediatric brain tumor at a depth of 5-10 cm; a head and neck tumor at a depth of 1-20 cm. Three-field, intensity modulated spot scanning proton plans were created for each site with the following parameter variations: min-MU limit range of 0.0000-0.0060; and spot spacing range of 2-8 mm. Comparisons were based on target homogeneity and normal tissue sparing. For the pediatric brain, two versions of the treatment planning system were also compared to judge the effects of the min-MU limit based on when it is accounted for in the optimization process (Eclipse v.10 and v.13, Varian Medical Systems, Palo Alto, CA). The increase of the min-MU limit with a fixed spot spacing decreases plan quality both in homogeneous target coverage and in the avoidance of critical structures. Both head and neck and pediatric brain plans show a 20% increase in relative dose for the hot spot in the CTV and 10% increase in key critical structures when comparing min-MU limits of 0.0000 and 0.0060 with a fixed spot spacing of 4 mm. The DVHs of CTVs show min-MU limits of 0.0000 and 0.0010 produce similar plan quality and quality decreases as the min-MU limit increases beyond 0.0020. As spot spacing approaches 8 mm, degradation in plan quality is observed when no min-MU limit is imposed. Given a fixed spot spacing of ≤4 mm, plan quality decreases as min-MU increased beyond 0.0020. The effect of min-MU needs to be taken into consideration while planning proton therapy treatments.

  10. Quality and safety in adult epilepsy monitoring units: A systematic review and meta-analysis.

    Science.gov (United States)

    Sauro, Khara M; Wiebe, Natalie; Macrodimitris, Sophie; Wiebe, Samuel; Lukmanji, Sara; Jetté, Nathalie

    2016-11-01

    The epilepsy monitoring unit (EMU) is a valuable resource for optimizing management of persons with epilepsy, but may place patients at risk for adverse events due to withdrawal of treatment and induction of symptoms. The purpose of this study was to synthesize data on the safety and quality of care in EMUs to inform the development of quality indicators for EMUs. A systematic review was conducted according to the Preferred Reporting and Items for Systematic Review and Meta-Analysis (PRISMA) statement. The search strategy, which included broad search terms and synonyms pertaining to the EMU, was run in six medical databases and included conference proceedings. Data abstracted included patient and EMU demographics and quality and safety variables. Study quality was evaluated using a modified 15-item Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist. Descriptive statistics and meta-analyses were used to describe and synthesize the evidence. The search yielded 7,601 references, of which 604 were reviewed in full text. One-hundred thirty-five studies were included. The quality and safety data came from 181,823 patients and reported on 34 different quality and safety variables. Included studies commonly reported the number of patients (108 studies; median number patients, 171.5), age (49 studies; mean age 35.7 years old), and the reason for admission (34 studies). The most common quality and safety data reported were the utility of the EMU admission (38 studies). Thirty-three studies (24.4%) reported on adverse events, and yielded a pooled proportion of adverse events of 7% (95% confidence interval [CI] 5-9%). The mean quality score was 73.3% (standard deviation [SD] 17.2). This study demonstrates that there is a great deal of variation in the reporting of quality and safety measures and in the quality and safety in EMUs. Study quality also varied considerably from one study to the next. These findings highlight the need to develop

  11. Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex.

    Science.gov (United States)

    Amangyeld, Tamir; Shin, Yong-Keol; Lee, Miju; Kwon, Buki; Seo, Yeon-Soo

    2014-05-01

    MUS81 shares a high-degree homology with the catalytic XPF subunit of the XPF-ERCC1 endonuclease complex. It is catalytically active only when complexed with the regulatory subunits Mms4 or Eme1 in budding and fission yeasts, respectively, and EME1 or EME2 in humans. Although Mus81 complexes are implicated in the resolution of recombination intermediates in vivo, recombinant yeast Mus81-Mms4 and human MUS81-EME1 isolated from Escherichia coli fail to cleave intact Holliday junctions (HJs) in vitro. In this study, we show that human recombinant MUS81-EME2 isolated from E. coli cleaves HJs relatively efficiently, compared to MUS81-EME1. Furthermore, MUS81-EME2 catalyzed cleavage of nicked and gapped duplex deoxyribonucleic acids (DNAs), generating double-strand breaks. The presence of a 5' phosphate terminus at nicks and gaps rendered DNA significantly less susceptible to the cleavage by MUS81-EME2 than its absence, raising the possibility that this activity could play a role in channeling damaged DNA duplexes that are not readily repaired into the recombinational repair pathways. Significant differences in substrate specificity observed with unmodified forms of MUS81-EME1 and MUS81-EME2 suggest that they play related but non-overlapping roles in DNA transactions. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  12. Report on public health actions and vaccination strategies to monitor measles epidemic in Local Health Unit A in Rome, Italy

    Directory of Open Access Journals (Sweden)

    Antonietta Spadea

    2012-03-01

    Full Text Available

    Abstract:
    Background: between May 2010 and october 2011 the unit of Preventive Medicine for the developmental ages of district IV, Health unit aSL rM/a, received 136 measles case notifications from the unit of Epidemiology and Prophylaxis of Infectious diseases.
    Methods: in accordance with the infectious diseases monitoring protocol, we introduced a series of preventive measures, such as monitoring subjects in contact with measles-infected patients, recommend- ing the administration of two Measles Mumps and rubella (MMr doses four weeks apart, and informing paediatricians, families and school teachers about the measles epidemic.
    Results: all the activities above led to an increased number of MMr doses administered and a significant improvement of measles immunization coverage among residents of the district IV health unit of rome. concerning MMr 1, in a sample cohort consisting of children ≤24 months, the immunization coverage increased from 77% on the 31/12/09 to 88% on the 31/12/11. Instead, for MMr 2, in a cohort of children ≤6 years, the same ratio improved from 51% on the 31/12/09 to 65% on the 31/12/11.
    Discussion: the results indicate a material increase in the immunization coverage once our public health actions and vaccination strategies had been implemented among young residents of district IV aSL rM/a...

  13. Monitoring of Persons with Risk for Exposure to Ebola Virus Disease - United States, November 3, 2014-March 8, 2015.

    Science.gov (United States)

    Stehling-Ariza, Tasha; Fisher, Emily; Vagi, Sara; Fechter-Leggett, Ethan; Prudent, Natasha; Dott, Mary; Daley, Randolph; Avchen, Rachel Nonkin

    2015-07-03

    On October 27, 2014, CDC released guidance for monitoring and movement of persons with potential Ebola virus disease (Ebola) exposure in the United States. For persons with possible exposure to Ebola, this guidance recommended risk categorization, daily monitoring during the 21-day incubation period, and, for persons in selected risk categories, movement restrictions. The purpose of the guidance was to delineate methods for early identification of symptoms among persons at potential risk for Ebola so that they could be isolated, tested, and if necessary, treated to improve their chance of survival and reduce transmission. Within 7 days, all 50 states and two local jurisdictions (New York City [NYC] and the District of Columbia [DC]) had implemented the guidelines. During November 3, 2014-March 8, 2015, a total of 10,344 persons were monitored for up to 21 days with >99% complete monitoring. This public health response demonstrated the ability of state, territorial, and local health agencies to rapidly implement systems to effectively monitor thousands of persons over a sustained period.

  14. Riparian Monitoring of Wadeable Streams Protocol for the Park Units in the Northern Colorado Plateau Network

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — A quick reviewed survey protocol framework developed by the National Park Service (NPS) and U.S. Geological Survey (USGS) for riparian monitoring of wadeable streams...

  15. Environmental Monitoring Plan United States Department of Energy Richland Operations Office. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-10

    This Environmental Monitoring Plan was prepared for the US Department of Energy`s (DOE`s) Richland Operations Office (RL) to implement the requirements of DOE Order 5400.1. According to the Order, each DOE site, facility, or activity that uses, generates, releases, or manages significant pollutants or hazardous materials shall prepare a written environmental monitoring plan covering two major activities: (1) effluent monitoring and (2) environmental surveillance. The plan is to contain information discussing the rationale and design criteria for the monitoring programs, sampling locations and schedules, quality assurance requirements, program implementation procedures, analytical procedures, and reporting requirements. The plan`s purpose is to assist DOE in the management of environmental activities at the Hanford Site and to help ensure that operations on the site are conducted in an environmentally safe and sound manner.

  16. Continuous EEG monitoring in adults in the intensive care unit (ICU).

    Science.gov (United States)

    André-Obadia, N; Parain, D; Szurhaj, W

    2015-03-01

    Continuous EEG monitoring in the ICU is different from planned EEG due to the rather urgent nature of the indications, explaining the fact that recording is started in certain cases by the clinical team in charge of the patient's care. Close collaboration between neurophysiology teams and intensive care teams is essential. Continuous EEG monitoring can be facilitated by quantified analysis systems. This kind of analysis is based on certain signal characteristics, such as amplitude or frequency content, but raw EEG data should always be interpreted if possible, since artefacts can sometimes impair quantified EEG analysis. It is preferable to work within a tele-EEG network, so that the neurophysiologist has the possibility to give an interpretation on call. Continuous EEG monitoring is thus useful in the diagnosis of non-convulsive epileptic seizures or purely electrical discharges and in the monitoring of status epilepticus when consciousness disorders persist after initial treatment. A number of other indications are currently under evaluation.

  17. Exploratory behavior of two species of murid rodents, Acomys cahirinus and Mus musculus: a comparative study.

    Science.gov (United States)

    Birke, L I; D'Udine, B; Albonetti, M E

    1985-03-01

    The exploratory behavior of two species of murid rodents, Acomys cahirinus and Mus musculus, was compared in four experiments: In the first, the responses of the two species to a novel arena were studied. Mus was found to take longer to enter the arena, and to spend more time in the relatively familiar or safer start box, than was Acomys. The results suggest that Acomys may persevere longer in exploring particular areas, whereas Mus appear to explore in the open arena by using frequent shifts of attention. The second experiment investigated species differences in response to the addition of a small novel object. Although the species did respond differently, the major species differences seemed to be related more to the open arena than to the object. The third experiment tested the hypothesis that both species would explore more if there was somewhere to hide (e.g., an artificial burrow) than if there was not. It was found that Acomys treated the available artificial burrow as another novel object, while Mus, as predicted, spent more time hiding inside it than did Acomys. The fourth experiment investigated burrow use when a model "predator" was introduced: Both species increased their use of the burrow but some species differences were found. Mus responded to the model more by freezing, or running immediately into the burrow; Acomys responded more by fleeing.

  18. Portable air quality sensor unit for participatory monitoring: an end-to-end VESNA-AQ based prototype

    Science.gov (United States)

    Vucnik, Matevz; Robinson, Johanna; Smolnikar, Miha; Kocman, David; Horvat, Milena; Mohorcic, Mihael

    2015-04-01

    Key words: portable air quality sensor, CITI-SENSE, participatory monitoring, VESNA-AQ The emergence of low-cost easy to use portable air quality sensors units is opening new possibilities for individuals to assess their exposure to air pollutants at specific place and time, and share this information through the Internet connection. Such portable sensors units are being used in an ongoing citizen science project called CITI-SENSE, which enables citizens to measure and share the data. The project aims through creating citizens observatories' to empower citizens to contribute to and participate in environmental governance, enabling them to support and influence community and societal priorities as well as associated decision making. An air quality measurement system based on VESNA sensor platform was primarily designed within the project for the use as portable sensor unit in selected pilot cities (Belgrade, Ljubljana and Vienna) for monitoring outdoor exposure to pollutants. However, functionally the same unit with different set of sensors could be used for example as an indoor platform. The version designed for the pilot studies was equipped with the following sensors: NO2, O3, CO, temperature, relative humidity, pressure and accelerometer. The personal sensor unit is battery powered and housed in a plastic box. The VESNA-based air quality (AQ) monitoring system comprises the VESNA-AQ portable sensor unit, a smartphone app and the remote server. Personal sensor unit supports wireless connection to an Android smartphone via built-in Wi-Fi. The smartphone in turn serves also as the communication gateway towards the remote server using any of available data connections. Besides the gateway functionality the role of smartphone is to enrich data coming from the personal sensor unit with the GPS location, timestamps and user defined context. This, together with an accelerometer, enables the user to better estimate ones exposure in relation to physical activities, time

  19. Stimulus probability effects on temporal bisection performance of mice (Mus musculus).

    Science.gov (United States)

    Akdoğan, Başak; Balcı, Fuat

    2016-01-01

    In the temporal bisection task, participants classify experienced stimulus durations as short or long based on their temporal similarity to previously learned reference durations. Temporal decision making in this task should be influenced by the experienced probabilities of the reference durations for adaptiveness. In this study, we tested the temporal bisection performance of mice (Mus musculus) under different short and long reference duration probability conditions implemented across two experimental phases. In Phase 1, the proportion of reference durations (compared to probe durations) was 0.5, whereas in Phase 2 it was increased to 0.8 to further examine the adjustment of choice behavior with more frequent reference duration presentations (under higher reinforcement rate). Our findings suggest that mice developed adaptive biases in their choice behaviors. These adjustments in choice behavior were nearly optimal as the mice maximized their gain to a great extent which required them to monitor stimulus probabilities as well as the level of variability in their temporal judgments. We further found that short but not long categorization response times were sensitive to stimulus probability manipulations, which in turn suggests an asymmetry between short and long categorizations. Finally, we investigated the latent decision processes underlying the bias manifested in subjects' choice behavior within the diffusion model framework. Our results revealed that probabilistic information influenced the starting point and the rate of evidence accumulation process. Overall, the stimulus probability effects on choice behavior were modulated by the reinforcement rate. Our findings illustrate that mice can adapt their temporal behaviors with respect to the probabilistic contingencies in the environment.

  20. Environmental Monitoring Report - United States Department of Energy, Oak Ridge Facilities, Calendar Year 1984

    Energy Technology Data Exchange (ETDEWEB)

    Jordan, R.G.

    1999-01-01

    Each year since 1972, a report has been prepared on the environmental monitoring activities for the DOE facilities in oak Ridge, Tennessee, for the previous calendar year. previously, the individual facilities published quarterly and annual progress reports that contained some environmental monitoring data. The environmental monitoring program for 1984 includes sampling and analysis of air, water from surface streams, groundwater, creek sediment, biota, and soil for both radioactive and nonradioactive (including hazardous) materials. Special environmental studies that have been conducted in the Oak Ridge area are included in this report, primarily as abstracts or brief summaries. The annual report for 1984 on environmental monitoring and surveillance of the Oak Ridge community by Oak Ridge Associated Universities (ORAU) is included as an appendix. A brief description of the topography and climate of the Oak Ridge area and a short description of the three DOE facilities are provided below to enhance the reader's understanding of the direction and contents of the environmental monitoring program for Oak Ridge.

  1. Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis.

    Directory of Open Access Journals (Sweden)

    Nigel J O'Neil

    Full Text Available The generation and resolution of joint molecule recombination intermediates is required to ensure bipolar chromosome segregation during meiosis. During wild type meiosis in Caenorhabditis elegans, SPO-11-generated double stranded breaks are resolved to generate a single crossover per bivalent and the remaining recombination intermediates are resolved as noncrossovers. We discovered that early recombination intermediates are limited by the C. elegans BLM ortholog, HIM-6, and in the absence of HIM-6 by the structure specific endonuclease MUS-81. In the absence of both MUS-81 and HIM-6, recombination intermediates persist, leading to chromosome breakage at diakinesis and inviable embryos. MUS-81 has an additional role in resolving late recombination intermediates in C. elegans. mus-81 mutants exhibited reduced crossover recombination frequencies suggesting that MUS-81 is required to generate a subset of meiotic crossovers. Similarly, the Mus81-related endonuclease XPF-1 is also required for a subset of meiotic crossovers. Although C. elegans gen-1 mutants have no detectable meiotic defect either alone or in combination with him-6, mus-81 or xpf-1 mutations, mus-81;xpf-1 double mutants are synthetic lethal. While mus-81;xpf-1 double mutants are proficient for the processing of early recombination intermediates, they exhibit defects in the post-pachytene chromosome reorganization and the asymmetric disassembly of the synaptonemal complex, presumably triggered by crossovers or crossover precursors. Consistent with a defect in resolving late recombination intermediates, mus-81; xpf-1 diakinetic bivalents are aberrant with fine DNA bridges visible between two distinct DAPI staining bodies. We were able to suppress the aberrant bivalent phenotype by microinjection of activated human GEN1 protein, which can cleave Holliday junctions, suggesting that the DNA bridges in mus-81; xpf-1 diakinetic oocytes are unresolved Holliday junctions. We propose that the

  2. Continuous stroke unit electrocardiographic monitoring versus 24-hour Holter electrocardiography for detection of paroxysmal atrial fibrillation after stroke.

    Science.gov (United States)

    Rizos, Timolaos; Güntner, Janina; Jenetzky, Ekkehart; Marquardt, Lars; Reichardt, Christine; Becker, Rüdiger; Reinhardt, Roland; Hepp, Thomas; Kirchhof, Paulus; Aleynichenko, Elena; Ringleb, Peter; Hacke, Werner; Veltkamp, Roland

    2012-10-01

    Cardioembolism in paroxysmal atrial fibrillation (pxAF) is a frequent cause of ischemic stroke. Sensitive detection of pxAF after stroke is crucial for adequate secondary stroke prevention; the optimal diagnostic modality to detect pxAF on stroke units is unknown. We compared 24-hour Holter electrocardiography (ECG) with continuous stroke unit ECG monitoring (CEM) for pxAF detection. Patients with acute ischemic stroke or transient ischemic attack were prospectively enrolled. After a 12-channel ECG on admission, all patients received 24-hour Holter ECG and CEM. Additionally, ECG monitoring data underwent automated analysis using dedicated software to identify pxAF. Patients with a history of atrial fibrillation or with atrial fibrillation on the admission ECG were excluded. Four hundred ninety-six patients (median age, 69 years; 61.5% male) fulfilled all inclusion criteria (ischemic stroke: 80.4%; transient ischemic attack: 19.6%). Median stroke unit stay lasted 88.8 hours (interquartile range, 65.0-122.0). ECG data for automated CEM analysis were available for a median time of 64.0 hours (43.0-89.8). Paroxysmal AF was documented in 41 of 496 patients (8.3%). Of these, Holter detected pxAF in 34.1%; CEM in 65.9%; and automated CEM in 92.7%. CEM and automated CEM detected significantly more patients with pxAF than Holter (PHolter ECG. The comparative usefulness of prolonged or repetitive Holter ECG recordings requires further evaluation.

  3. Performance monitoring of a multi-unit solar domestic hot water system

    Energy Technology Data Exchange (ETDEWEB)

    Makuch, P.D.; Harrison, S.J. [Queen`s Univ., Kingston, ON (Canada). Solar Calorimetry Lab.

    1994-12-01

    A solar domestic hot water (SDHW) system was installed on an existing multi-family apartment building in 1991. Energy monitoring hardware was installed in 1992. It was a preheat system that was retrofitted upstream of existing hot water tanks located in the building. Monitoring of the system continued for eight months. As a result of this monitoring, average daily values could be made available for each month, as well as values of incident solar radiation, outdoor temperature, hot water use, total system energy, auxiliary energy, solar energy delivered to the load, energy loss from the recirculation loop and pump run time. Performance results indicated that the system performed at a level close to simulated values, but that system performance during the summer period was severely reduced due to low hot water usage. 5 refs., 12 figs., 2 tabs.

  4. 2012 Groundwater Monitoring Report Central Nevada Test Area, Subsurface Corrective Action Unit 443

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-04-01

    The Central Nevada Test Area was the site of a 0.2- to 1-megaton underground nuclear test in 1968. The surface of the site has been closed, but the subsurface is still in the corrective action process. The corrective action alternative selected for the site was monitoring with institutional controls. Annual sampling and hydraulic head monitoring are conducted as part of the subsurface corrective action strategy. The site is currently in the fourth year of the 5-year proof-of-concept period that is intended to validate the compliance boundary. Analytical results from the 2012 monitoring are consistent with those of previous years. Tritium remains at levels below the laboratory minimum detectable concentration in all wells in the monitoring network. Samples collected from reentry well UC-1-P-2SR, which is not in the monitoring network but was sampled as part of supplemental activities conducted during the 2012 monitoring, indicate concentrations of tritium that are consistent with previous sampling results. This well was drilled into the chimney shortly after the detonation, and water levels continue to rise, demonstrating the very low permeability of the volcanic rocks. Water level data from new wells MV-4 and MV-5 and recompleted well HTH-1RC indicate that hydraulic heads are still recovering from installation and testing. Data from wells MV-4 and MV-5 also indicate that head levels have not yet recovered from the 2011 sampling event during which several thousand gallons of water were purged. It has been recommended that a low-flow sampling method be adopted for these wells to allow head levels to recover to steady-state conditions. Despite the lack of steady-state groundwater conditions, hydraulic head data collected from alluvial wells installed in 2009 continue to support the conceptual model that the southeast-bounding graben fault acts as a barrier to groundwater flow at the site.

  5. Wireless Monitoring in Intensive Care Units by a 3D-Printed System with Embedded Electronics

    OpenAIRE

    Basilotta, Flavia; Riario, Stefano; Stradolini, Francesca; Taurino, Irene; Demarchi, Danilo; De Micheli, Giovanni; Carrara, Sandro

    2015-01-01

    The design, realization, and preliminary test of a portable wireless system for measuring key metabolites (e.g., glucose, lactate, calcium, potassium, etc..) in intensive cure monitoring is presented. The system is composed by a 3D-Printed case, which includes the fluidic system that drives the monitored human fluids on top of the sensing devices. The case fully integrates a hardware platform on PCB that connects the biosensors to the read-out frontend and to a Bluetooth® module for the data ...

  6. Auditing of Monitoring and Respiratory Support Equipment in a Level III-C Neonatal Intensive Care Unit

    Directory of Open Access Journals (Sweden)

    Elena Bergon-Sendin

    2015-01-01

    Full Text Available Background. Random safety audits (RSAs are a safety tool but have not been widely used in hospitals. Objectives. To determine the frequency of proper use of equipment safety mechanisms in relation to monitoring and mechanical ventilation by performing RSAs. The study also determined whether factors related to the patient, time period, or characteristics of the area of admission influenced how the device safety systems were used. Methods. A prospective observational study was conducted in a level III-C Neonatal Intensive Care Unit (NICU during 2012. 87 days were randomly selected. Appropriate overall use was defined when all evaluated variables were correctly programmed in the audited device. Results. A total of 383 monitor and ventilator audits were performed. The Kappa coefficient of interobserver agreement was 0.93. The rate of appropriate overall use of the monitors and respiratory support equipment was 33.68%. Significant differences were found with improved usage during weekends, OR 1.85 (1.12–3.06, p=0.01, and during the late shift (3 pm to 10 pm, OR 1.59 (1.03–2.4, p=0.03. Conclusions. Equipment safety systems of monitors and ventilators are not properly used. To improve patient safety, we should identify which alarms are really needed and where the difficulties lie for the correct alarm programming.

  7. Wireless sensor and data transmission needs and technologies for patient monitoring in the operating room and intensive care unit.

    Science.gov (United States)

    Paksuniemi, M; Sorvoja, H; Alasaarela, E; Myllyla, R

    2005-01-01

    In the intensive care unit, or during anesthesia, patients are attached to monitors by cables. These cables obstruct nursing staff and hinder the patients from moving freely in the hospital. However, rapidly developing wireless technologies are expected to solve these problems. To this end, this study revealed problem areas in current patient monitoring and established the most important medical parameters to monitor. In addition, usable wireless techniques for short-range data transmission were explored and currently employed wireless applications in the hospital environment were studied. The most important parameters measured of the patient include blood pressures, electrocardiography, respiration rate, heart rate and temperature. Currently used wireless techniques in hospitals are based on the WMTS and WLAN standards. There are no viable solutions for short-range data transmission from patient sensors to patient monitors, but potentially usable techniques in the future are based on the WPAN standards. These techniques include Bluetooth, ZigBee and UWB. Other suitable techniques might be based on capacitive or inductive coupling. The establishing of wireless techniques depends on ensuring the reliability of data transmission, eliminating disturbance by other wireless devices, ensuring patient data security and patient safety, and lowering the power consumption and price.

  8. Musées d’entreprise : un genre composite

    OpenAIRE

    Cousserand, Isabelle

    2011-01-01

    Que recouvrent les musées d’entreprise ? Quelles sont leurs spécificités ? Comment peut-on les caractériser ? Souvent associés aux circuits de visites d’une organisation ou d’une entreprise, ces espaces muséaux ne sont spécifiés par aucune nomenclature, prennent des formes multiples et répondent à des objectifs variés. À travers un corpus de musées créés par des organisations de différents secteurs, il s’agit de mieux les cerner et de montrer en quoi ces dispositifs participent de la communic...

  9. High-spin {\\mu}s isomeric states in 96Ag

    CERN Document Server

    Becerril, A D; Amthor, A M; Baumann, T; Bazin, D; Berryman, J S; Brown, B A; Crawford, H L; Estrade, A; Gade, A; Ginter, T; Guess, C J; Hausmann, M; Hitt, G W; Mantica, P F; Matos, M; Meharchand, R; Minamisono, K; Montes, F; Perdikakis, G; Pereira, J; Portillo, M; Schatz, H; Smith, K; Stoker, J; Stolz, A; Zegers, R G T

    2011-01-01

    The isomeric and {\\beta} decays of the N = Z +2 nucleus 96Ag were investigated at NSCL. A cascade of {\\gamma}-ray transitions originating from the de-excitation of a {\\mu}s isomer was observed for the first time and was found in coincidence with two previously-known transitions with energies of 470 and 667 keV. The isomeric half-life was determined as 1.45(7) {\\mu}s, more precise than previously reported. The existence of a second, longer-lived {\\mu}s isomer, associated with a 743-keV transition, is also proposed here. Shell model results within the (p_{3/2}p_{1/2}f_{5/2}g_{9/2}) model space, using the jj44b interaction, reproduced level energies and isomeric decay half-lives reasonably well.

  10. X-ray Detection of the Cluster Containing the Cepheid S Mus

    CERN Document Server

    Evans, Nancy Remage; Wolk, Scott J; Guinan, Edward; Engle, Scott; Bond, Howard E; Schaefer, Gail H; Karovska, Margarita; DePasquale, Joseph; Tingle, Evan

    2014-01-01

    The galactic Cepheid S Muscae has recently been added to the important list of Cepheids linked to open clusters, in this case the sparse young cluster ASCC 69. Low-mass members of a young cluster are expected to have rapid rotation and X-ray activity, making X-ray emission an excellent way to discriminate them from old field stars. We have made an XMM-Newton observation centered on S Mus and identified (Table 1) a population of X-ray sources whose near-IR 2MASS counterparts lie at locations in the J, (J-K) color-magnitude diagram consistent with cluster membership at the distance of S Mus. Their median energy and X-ray luminosity are consistent with young cluster members as distinct from field stars. These strengthen the association of S Mus with the young cluster, making it a potential Leavitt Law (Period-Luminosity relation) calibrator.

  11. POSSuMUS: a position sensitive scintillating muon SiPM detector

    CERN Document Server

    Ruschke, Alexander

    The development of a modular designed large scale scintillation detector with a two-dimensional position sensitivity is presented in this thesis. This novel POsition Sensitive Scintillating MUon SiPM Detector is named POSSuMUS. The POSSuMUS detector is capable to determine the particle’s position in two space dimensions with a fast trigger capability. Each module is constructed from two trapezoidal shaped plastic scintillators to form one rectangular shaped detector module. Both trapezoids are optically insulated against each other. In both trapezoids the scintillation light is collected by plastic fibers and guided towards silicon photomultipliers (SiPMs). SiPMs are light sensors which are capable to detect even smallest amounts of light. By combining several detector modules, position sensitive areas from 100 cm2 to few m2 are achievable with few readout channels. Therefore, POSSuMUS provides a cost effective detector concept. The position sensitivity along the trapezoidal geometry of one detector module ...

  12. Heart rate monitoring on the stroke unit. What does heart beat tell about prognosis? An observational study

    Directory of Open Access Journals (Sweden)

    Stypmann Jörg

    2011-04-01

    Full Text Available Abstract Background Guidelines recommend maintaining the heart rate (HR of acute stroke patients within physiological limits; data on the frequency and predictors of significant deviations from these limits are scarce. Methods Demographical data, stroke risk factors, NIH stroke scale score, lesion size and location, and ECG parameters were prospectively assessed in 256 patients with ischemic stroke. Patients were continuously monitored for at least 24 hours on a certified stroke unit. Tachycardia (HR ≥120 bpm and bradycardia (HR Results HR ≥120 bpm occurred in 39 patients (15%. Stroke severity (larger lesion size/higher NIHSS-score on admission, atrial fibrillation and HR on admission predicted its occurrence. HR Conclusions Significant tachycardia and bradycardia are frequent phenomena in acute stroke; however they do not independently predict clinical course or outcome. Continuous monitoring allows detecting rhythm disturbances in stroke patients and allows deciding whether urgent medical treatment is necessary.

  13. Haemodynamic Monitoring in the Intensive Care Unit: Results from a Web-Based Swiss Survey

    Directory of Open Access Journals (Sweden)

    Nils Siegenthaler

    2014-01-01

    Full Text Available Background. The aim of this survey was to describe, in a situation of growing availability of monitoring devices and parameters, the practices in haemodynamic monitoring at the bedside. Methods. We conducted a Web-based survey in Swiss adult ICUs (2009-2010. The questionnaire explored the kind of monitoring used and how the fluid management was addressed. Results. Our survey included 71% of Swiss ICUs. Echocardiography (95%, pulmonary artery catheter (PAC: 85%, and transpulmonary thermodilution (TPTD (82% were the most commonly used. TPTD and PAC were frequently both available, although TPTD was the preferred technique. Echocardiography was widely available (95% but seems to be rarely performed by intensivists themselves. Guidelines for the management of fluid infusion were available in 45% of ICUs. For the prediction of fluid responsiveness, intensivists rely preferentially on dynamic indices or echocardiographic parameters, but static parameters, such as central venous pressure or pulmonary artery occlusion pressure, were still used. Conclusions. In most Swiss ICUs, multiple haemodynamic monitoring devices are available, although TPTD is most commonly used. Despite the usefulness of echocardiography and its large availability, it is not widely performed by Swiss intensivists themselves. Regarding fluid management, several parameters are used without a clear consensus for the optimal method.

  14. Interest of Monitoring Diaphragmatic Electrical Activity in the Pediatric Intensive Care Unit

    Directory of Open Access Journals (Sweden)

    Laurence Ducharme-Crevier

    2013-01-01

    Full Text Available The monitoring of electrical activity of the diaphragm (EAdi is a new minimally invasive bedside technology that was developed for the neurally adjusted ventilatory assist (NAVA mode of ventilation. In addition to its role in NAVA ventilation, this technology provides the clinician with previously unavailable and essential information on diaphragm activity. In this paper, we review the clinical interests of EAdi in the pediatric intensive care setting. Firstly, the monitoring of EAdi allows the clinician to tailor the ventilatory settings on an individual basis, avoiding frequent overassistance leading potentially to diaphragmatic atrophy. Increased inspiratory EAdi levels can also suggest insufficient support, while a strong tonic activity may reflect the patient efforts to increase its lung volume. EAdi monitoring also allows detection of patient-ventilator asynchrony. It can play a role in evaluation of extubation readiness. Finally, EAdi monitoring provides the clinician with better understanding of the ventilatory capacity of patients with acute neuromuscular disease. Further studies are warranted to evaluate the clinical impact of these potential benefits.

  15. Continuous EEG monitoring in the intensive care unit: beta scientific and management scientific aspects

    NARCIS (Netherlands)

    Sanders, P.M.H.; van Putten, M.J.A.M.; Jarm, T.; Kramar, P.; Zupanic, A.

    2007-01-01

    Due to various technological advances, it is now possible to continuously monitor critically ill patients using EEG, including the extraction of various quantitative features. In this study, several beta scientific and management scientific aspects of the implementation and use of cEEg on the ICU wi

  16. Continuous EEG monitoring in the intensive care unit: beta scientific and management scientific aspects

    NARCIS (Netherlands)

    Sanders, P.M.H.; van Putten, Michel Johannes Antonius Maria; Jarm, T.; Kramar, P.; Zupanic, A.

    2007-01-01

    Due to various technological advances, it is now possible to continuously monitor critically ill patients using EEG, including the extraction of various quantitative features. In this study, several beta scientific and management scientific aspects of the implementation and use of cEEg on the ICU

  17. Verification of monitor unit calculations for non-IMRT clinical radiotherapy: report of AAPM Task Group 114.

    Science.gov (United States)

    Stern, Robin L; Heaton, Robert; Fraser, Martin W; Goddu, S Murty; Kirby, Thomas H; Lam, Kwok Leung; Molineu, Andrea; Zhu, Timothy C

    2011-01-01

    The requirement of an independent verification of the monitor units (MU) or time calculated to deliver the prescribed dose to a patient has been a mainstay of radiation oncology quality assurance. The need for and value of such a verification was obvious when calculations were performed by hand using look-up tables, and the verification was achieved by a second person independently repeating the calculation. However, in a modern clinic using CT/MR/PET simulation, computerized 3D treatment planning, heterogeneity corrections, and complex calculation algorithms such as convolution/superposition and Monte Carlo, the purpose of and methodology for the MU verification have come into question. In addition, since the verification is often performed using a simpler geometrical model and calculation algorithm than the primary calculation, exact or almost exact agreement between the two can no longer be expected. Guidelines are needed to help the physicist set clinically reasonable action levels for agreement. This report addresses the following charges of the task group: (1) To re-evaluate the purpose and methods of the "independent second check" for monitor unit calculations for non-IMRT radiation treatment in light of the complexities of modern-day treatment planning. (2) To present recommendations on how to perform verification of monitor unit calculations in a modern clinic. (3) To provide recommendations on establishing action levels for agreement between primary calculations and verification, and to provide guidance in addressing discrepancies outside the action levels. These recommendations are to be used as guidelines only and shall not be interpreted as requirements.

  18. The Development and Evaluation of the Multi-Unit Elementary School. Maxi II Practicum Report.

    Science.gov (United States)

    Durham, Joe D.

    The purpose of this practicum was to show the development and evaluation of a multi-unit elementary school (MUS-E) using Individually Guided Education. As an organizational structure capable of permitting planned change. MUS-E provides for the growth of its students on an individual basis, provides in-service for its teachers, involves the public…

  19. 2012 Groundwater Monitoring Report Project Shoal Area Subsurface Corrective Action Unit 447

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-03-01

    The Project Shoal Area (PSA) in Nevada was the site of a 12-kiloton underground nuclear test in 1963. Although the surface of the site has been remediated, investigation of groundwater contamination resulting from the test is still in the corrective action process. Annual sampling and hydraulic head monitoring are conducted at the site as part of the subsurface corrective action strategy. Analytical results from the 2012 monitoring are consistent with those of the previous years, with tritium detected only in well HC-4. The tritium concentration in groundwater from well HC-4 remains far below the U.S. Environmental Protection Agency-established maximum contaminant level of 20,000 picocuries per liter. Concentrations of total uranium and gross alpha were also detected during this monitoring period, with uranium accounting for nearly all the gross alpha activity. The total uranium concentrations obtained from this monitoring period were consistent with previous results and reflect a slightly elevated natural uranium concentration, consistent with the mineralized geologic terrain. Isotopic ratios of uranium also indicate a natural source of uranium in groundwater, as opposed to a nuclear-test-related source. Water level trends obtained from the 2012 water level data were consistent with those of previous years. The corrective action strategy for the PSA is currently focused on revising the site conceptual model (SCM) and evaluating the adequacy of the current monitoring well network. Some aspects of the SCM are known; however, two major concerns are the uncertainty in the groundwater flow direction and the cause of rising water levels in site wells west of the shear zone. Water levels have been rising in the site wells west of the shear zone since the first hydrologic characterization wells were installed in 1996. While water levels in wells west of the shear zone continue to rise, the rate of increase is less than in previous years. The SCM will be revised, and an

  20. Predicting business unit performance using employee surveys: Monitoring HRM-related changes

    NARCIS (Netherlands)

    Voorde, F.C. van de; Paauwe, J.; Veldhoven, M.J.P.M. van

    2010-01-01

    Organisations are increasingly using strategy tools such as workforce scorecards to keep track of human resource management related change processes that have been implemented and the effects of these on business unit performance. However, in this area, the challenge of finding appropriate

  1. CHIPS: Monitoring Colonias along the United States-Mexico border in Texas

    Science.gov (United States)

    Parcher, Jean W.

    2008-01-01

    Colonias, which are unincorporated border settlements in the United States, have emerged in rural areas without the governance and services normally provided by local government. The expansion of colonias in the United States-Mexico border region can be traced to the rapid growth associated with the Mexican Border Industrial Program during the 1960s. This rapid population growth created a lack of affordable housing, causing new migrants in the United States to purchase rural homestead lots through a contract-for-deed program from land developers. Because of the need to keep prices affordable and the absence of effective land-use controls, these homesteads expanded into rural subdivisions, commonly called colonias, without proper infrastructure. Colonias have been identified in the four U.S. border states, with Texas having designated the majority, which numbered over 1,400 colonias in 2001. Because the region is binationally interconnected economically, politically, and socially, the phenomenon of colonias in the United States is a transborder issue.

  2. Downhole Microseismic Monitoring at a Carbon Capture, Utilization, and Storage Site, Farnsworth Unit, Ochiltree County, Texas

    Science.gov (United States)

    Ziegler, A.; Balch, R. S.; van Wijk, J.

    2015-12-01

    Farnsworth Oil Field in North Texas hosts an ongoing carbon capture, utilization, and storage project. This study is focused on passive seismic monitoring at the carbon injection site to measure, locate, and catalog any induced seismic events. A Geometrics Geode system is being utilized for continuous recording of the passive seismic downhole bore array in a monitoring well. The array consists of 3-component dual Geospace OMNI-2400 15Hz geophones with a vertical spacing of 30.5m. Downhole temperature and pressure are also monitored. Seismic data is recorded continuously and is produced at a rate of over 900GB per month, which must be archived and reviewed. A Short Term Average/Long Term Average (STA/LTA) algorithm was evaluated for its ability to search for events, including identification and quantification of any false positive events. It was determined that the algorithm was not appropriate for event detection with the background level of noise at the field site and for the recording equipment as configured. Alternatives are being investigated. The final intended outcome of the passive seismic monitoring is to mine the continuous database and develop a catalog of microseismic events/locations and to determine if there is any relationship to CO2 injection in the field. Identifying the location of any microseismic events will allow for correlation with carbon injection locations and previously characterized geological and structural features such as faults and paleoslopes. Additionally, the borehole array has recorded over 1200 active sources with three sweeps at each source location that were acquired during a nearby 3D VSP. These data were evaluated for their usability and location within an effective radius of the array and were stacked to improve signal-noise ratio and are used to calibrate a full field velocity model to enhance event location accuracy. Funding for this project is provided by the U.S. Department of Energy under Award No. DE-FC26-05NT42591.

  3. EcoNum, a research unit devoted to marine environment monitoring

    OpenAIRE

    Richir, Jonathan; Batigny, Antoine; Georges, Nadège; Fullgrabe, Lovina; Suvarov, Paul; Gobert, Sylvie; Lepoint, Gilles; Borges, Alberto; Champenois, Willy; Franck, Fabrice; Roberty, Stéphane; Lejeune, Pierre; Abadie, Arnaud; Leduc, Michèle; Boissery, Pierre

    2016-01-01

    The monitoring of coastal environments remains a research domain of great interest and concern. Coastal ecosystems are threatened by natural and human-induced stressors and are, as transitional environments, particularly sensitive to disturbances. EcoNum first research thematic revolves around hermatypic corals, calcifying organisms, and their adaptation potentials to environmental changes including by using original and patented chemostats. The studied organisms are grown and maintained i...

  4. [Gastric mucosa tonometry in routine monitoring in the surgical intensive care unit].

    Science.gov (United States)

    Pestel, G; Uhlig, T; Götschl, A; Schmucker, P; Rothhammer, A

    1998-06-01

    Monitoring tissue oxygenation in the splanchnic region could be helpful for critically ill patients. In this study the postoperative course of gastric mucosal CO2 (prCO2) in 40 patients is shown. Following approval of the ethics committee, 24 patients schedulded for surgery with an expected large fluid turnover and 16 multiple injured patients were monitored with a gas tonometry device in addition to standard monitoring (ECG, pulse oximetry, capnometry, CVP, arterial pressure). Normoventilated patients with prCO2 > 50 for more than 30 minutes were treated with fluid therapy, followed by catecholamine therapy, followed by transfusion (fig. 1). All patients were admitted to the SICU post-operatively. The variation of prCO2-values was greater in multiple injured patients. Their prCO2-values began in a lower range compared to patients with scheduled operation, became higher at the end of the first SICU-day and remained higher thereafter. They had a higher fluid turnover and needed more catecholamines. Multiple injured patients with an arterio-intestinal CO2-Difference (CO2-Gap) > 10 had a higher ISS-Score, were longer mechanically ventilated, had a longer SICU-stay and a higher incidence of complications in comparison to patients with aCO2-Gap 10 could be predictive for a more severe course in intensive care patients.

  5. 2015 Groundwater Monitoring Report Project Shoal Area: Subsurface Correction Unit 447

    Energy Technology Data Exchange (ETDEWEB)

    Findlay, Rick [Navarro Research and Engineering, Oak Ridge, TN (United States)

    2016-04-01

    The Project Shoal Area in Nevada was the site of a 12-kiloton-yield underground nuclear test in 1963. Although the surface of the site has been remediated, investigation of groundwater contamination resulting from the test is still in the corrective action process. Annual sampling and hydraulic head monitoring are conducted at the site as part of the subsurface corrective action strategy. The corrective action strategy is currently focused on revising the site conceptual model (SCM) and evaluating the adequacy of the monitoring well network. Some aspects of the SCM are known; however, two major concerns are the uncertainty in the groundwater flow direction and the cause of rising water levels in site wells west of the shear zone. Water levels have been rising in the site wells west of the shear zone since the first hydrologic characterization wells were installed in 1996. Although water levels in wells west of the shear zone continue to rise, the rate of increase is less than in previous years. The SCM will be revised, and an evaluation of the groundwater monitoring network will be conducted when water levels at the site have stabilized to the agreement of both the U.S. Department of Energy Office of Legacy Management and the Nevada Division of Environmental Protection.

  6. Global positioning system measurements over a strain monitoring network in the eastern two-thirds of the United States

    Energy Technology Data Exchange (ETDEWEB)

    Strange, W.E.

    1991-09-01

    A 45-station geodetic network was established in 1987 using global positioning system (GPS) technology to provide a means of monitoring strain and deformation in the central and eastern United States. Reduction of the initial epoch data showed that accuracies of 1 to 3 cm can be achieved for horizontal position, provided sufficient observations are available and there are four or more fiducial stations whose positions are known a priori, for example from Very Long Baseline Interferometry measurements. Accuracies obtained provide the ability to determine strain at the 1:10{sup 7} to 1:10{sup 8} level. Vertical positions are less accurate because of problems in modeling refraction and are determined at the 5 to 7 cm level. It is planned to remeasure this network at regular intervals in the coming years to place bounds on the strain occurring in the central and eastern United States. This network is also expected to serve as a reference network for more detailed monitoring networks in areas of high risk such as the New Madrid area. Future measurements are expected to provide more accurate results because of increased numbers of GPS satellites available and improved computation software. The improved software will also allow future upgrading of the accuracy of the 1987 observations. 3 figs., 5 tabs.

  7. Synthesis of marine ecosystem monitoring activities for the United States Virgin Islands: 1990-2009

    OpenAIRE

    2012-01-01

    The ecological integrity of coral reef ecosystems in the U.S. Caribbean is widely considered to have deteriorated in the last three decades due to a range of threats and stressors from both human and non-human processes Rothenberger 2008, Wilkinson 2008). In response to the threats to Caribbean coral reef ecosystems and other regions around the world, the United States Government authorized the Coral Reef Conservation Act of 2000 to: (1) preserve, sustain, and restore the condition of coral r...

  8. Exploring measurement biases associated with esophageal Doppler monitoring in critically ill patients in intensive care unit

    Directory of Open Access Journals (Sweden)

    Stawicki Peter

    2007-01-01

    Full Text Available Background : Esophageal Doppler monitoring (EDM is utilized in numerous clinical settings. This study examines the relationship between pulmonary artery catheter (PAC and EDM-derived hemodynamic parameters, concentrating on gender- and age-related EDM measurement biases. Materials and Methods : Prospective study of EDM use in ventilated surgical ICU patients. Parameters examined included demographics, diagnosis, resuscitation endpoints, cardiac output (CO and stroke volume from both devices, number of personnel and time needed to place equipment, time to data acquisition, duration of use, complications of placement. Results : Fifteen patients (11 men, 4 women, mean age 47 years were included. Most common diagnoses included trauma (7/15 and sepsis (4/15. Insertion time and time to data acquisition were shorter for EDM than for PAC ( P < 0.001. The EDM required an average of 1.1 persons to place (2.4 for PAC, P =0.002. Mean EDM utilization time was 12.4 h. There was a fair CO correlation between EDM and PAC (r = 0.647, P < 0.001. Overall, the EDM underestimated CO relative to PAC (bias -1.42 ± 2.08, 95% CI: -5.58-2.74, with more underestimation in women (mean bias difference of -1.16, P < 0.001. No significant age-related measurement bias differences between PAC and EDM were noted. Significant reductions in lactate and norepinephrine requirement were noted following EDM monitoring periods. Conclusions : This study found that the EDM significantly underestimated cardiac output in women when compared to PAC. Clinicians should be aware of this measurement bias when making therapeutic decision based on EDM data. Significant reductions in lactate and norepinephrine requirement during EDM monitoring periods support the clinical usefulness of EDM technology.

  9. Measurement of the dosimetric parameters for low monitor units in step-and-shoot IMRT delivered by Siemens Artiste linear accelerators; Medida de los parametros dosimetricos para bajo numero de unidades monitor en IMRT segmentada estatica administrada por aceleradores lineales Siemens Artiste

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez Rodriguez, C.; Lopez Fernandez, A.; Saez Beltran, M.; Martin Martin, G.; Alonso Iracheta, L.

    2012-07-01

    Absorbed dose linearity and beam stability, both for low monitor units, are important factors for ensuring planned dose delivery in step-and-shoot IMRT. For Siemens Artiste linear accelerators, under IMRT stable irradiation conditions and for a single segment of 20 cm x 20 cm field size, the linearity of the absorbed dose with the monitor units, field flatness and symmetry have been measured for the range between 1 and 10 monitor units. We have found that absorbed dose linearity with monitor units is within 2% down to 2 monitor units and it is about 9% for 1 monitor unit. Flatness and symmetry values show variations within 1% down to 2 monitor units and increase by 9% for lower values. Using our monitor unit distribution per segment in IMRT we estimate that the uncertainty in absorbed dose for a whole treatment due to these factors is less than 1% (k= 3). (Author) 13 refs.

  10. Design of an Integrated Sensor Platform for Vital Sign Monitoring of Newborn Infants at Neonatal Intensive Care Units

    Directory of Open Access Journals (Sweden)

    Wei Chen

    2010-01-01

    Full Text Available Continuous health status monitoring and advances in medical treatments have resulted in a significant increase of survival rate in critically ill infants admitted into Neonatal Intensive Care Units (NICUs. The quality of life and long-term health prospects of the neonates depend increasingly on the reliability and comfort of the monitoring systems. In this paper, we present the design work of a smart jacket for vital sign monitoring of neonates at a NICU. The design represents a unique integration of sensor technology, user focus and design aspects. Textile sensors, a reflectance pulse oximeter and a wearable temperature sensor were proposed to be embedded into the smart jacket. Location of the sensor, materials and appearance were designed to optimize the functionality, patient comfort and the possibilities for aesthetic features. Prototypes were built for demonstrating the design concept and experimental results were obtained from tests on premature babies at the NICU of M�xima Medical Centre (MMC in Veldhoven, the Netherlands.

  11. Evaluating an Enhanced Vegetation Condition Index (VCI Based on VIUPD for Drought Monitoring in the Continental United States

    Directory of Open Access Journals (Sweden)

    Wenzhe Jiao

    2016-03-01

    Full Text Available Drought is a complex hazard, and it has an impact on agricultural, ecological, and socio-economic systems. The vegetation condition index (VCI, which is derived from remote-sensing data, has been widely used for drought monitoring. However, VCI based on the normalized difference vegetation index (NDVI does not perform well in certain circumstances. In this study, we examined the utility of the vegetation index based on the universal pattern decomposition method (VIUPD based VCI for drought monitoring in various climate divisions across the continental United States (CONUS. We compared the VIUPD-derived VCI with the NDVI-derived VCI in various climate divisions and during different sub-periods of the growing season. It was also compared with other remote-sensing-based drought indices, such as the temperature condition index (TCI, precipitation condition index (PCI and the soil moisture condition index (SMCI. The VIUPD-derived VCI had stronger correlations with long-term in situ drought indices, such as the Palmer Drought Severity Index (PDSI and the standardized precipitation index (SPI-3, SPI-6, SPI-9, and SPI-12 than did the NDVI-derived VCI, and other indices, such as TCI, PCI and SMCI. The VIUPD has considerable potential for drought monitoring. As VIUPD can make use of the information from all the observation bands, the VIUPD-derived VCI can be regarded as an enhanced VCI.

  12. Intermittent auscultation versus continuous fetal monitoring: exploring factors that influence birthing unit nurses' fetal surveillance practice using theoretical domains framework.

    Science.gov (United States)

    Patey, Andrea M; Curran, Janet A; Sprague, Ann E; Francis, Jill J; Driedger, S Michelle; Légaré, France; Lemyre, Louise; Pomey, Marie-Pascale A; Grimshaw, Jeremy M

    2017-09-25

    Intermittent Auscultation (IA) is the recommended method of fetal surveillance for healthy women in labour. However, the majority of women receive continuous electronic monitoring. We used the Theoretical Domains Framework (TDF) to explore the views of Birthing Unit nurses about using IA as their primary method of fetal surveillance for healthy women in labour. Using a semi-structured interview guide, we interviewed a convenience sample of birthing unit nurses throughout Ontario, Canada to elicit their views about fetal surveillance. Interviews were recorded and transcribed verbatim. Transcripts were content analysed using the TDF and themes were framed as belief statements. Domains potentially key to changing fetal surveillance behaviour and informing intervention design were identified by noting the frequencies of beliefs, content, and their reported influence on the use of IA. We interviewed 12 birthing unit nurses. Seven of the 12 TDF domains were perceived to be key to changing birthing unit nurses' behaviour The nurses reported that competing tasks, time constraints and the necessity to multitask often limit their ability to perform IA (domains Beliefs about capabilities; Environmental context and resources). Some nurses noted the decision to use IA was something that they consciously thought about with every patient while others stated it their default decision as long as there were no risk factors (Memory, attention and decision processes, Nature of behaviour). They identified positive consequences (e.g. avoid unnecessary interventions, mother-centered care) and negative consequences of using IA (e.g. legal concerns) and reported that the negative consequences can often outweigh positive consequences (Beliefs about consequences). Some reported that hospital policies and varying support from care teams inhibited their use of IA (Social influences), and that support from the entire team and hospital management would likely increase their use (Social

  13. Randomized trial of automated, electronic monitoring to facilitate early detection of sepsis in the intensive care unit*.

    Science.gov (United States)

    Hooper, Michael H; Weavind, Lisa; Wheeler, Arthur P; Martin, Jason B; Gowda, Supriya Srinivasa; Semler, Matthew W; Hayes, Rachel M; Albert, Daniel W; Deane, Norment B; Nian, Hui; Mathe, Janos L; Nadas, Andras; Sztipanovits, Janos; Miller, Anne; Bernard, Gordon R; Rice, Todd W

    2012-07-01

    To determine whether automated identification with physician notification of the systemic inflammatory response syndrome in medical intensive care unit patients expedites early administration of new antibiotics or improvement of other patient outcomes in patients with sepsis. : A prospective randomized, controlled, single center study. Medical intensive care unit of an academic, tertiary care medical center. Four hundred forty-two consecutive patients admitted over a 4-month period who met modified systemic inflammatory response syndrome criteria in a medical intensive care unit. Patients were randomized to monitoring by an electronic "Listening Application" to detect modified (systemic inflammatory response syndrome) criteria vs. usual care. The listening application notified physicians in real time when modified systemic inflammatory response syndrome criteria were detected, but did not provide management recommendations. The median time to new antibiotics was similar between the intervention and usual care groups when comparing among all patients (6.0 hr vs. 6.1 hr, p = .95), patients with sepsis (5.3 hr vs. 5.1 hr; p = .90), patients on antibiotics at enrollment (5.2 hr vs. 7.0 hr, p = .27), or patients not on antibiotics at enrollment (5.2 hr vs. 5.1 hr, p = .85). The amount of fluid administered following detection of modified systemic inflammatory response syndrome criteria was similar between groups whether comparing all patients or only patients who were hypotensive at enrollment. Other clinical outcomes including intensive care unit length of stay, hospital length of stay, and mortality were not shown to be different between patients in the intervention and control groups. Realtime alerts of modified systemic inflammatory response syndrome criteria to physicians in one tertiary care medical intensive care unit were feasible and safe but did not influence measured therapeutic interventions for sepsis or significantly alter clinical outcomes.

  14. Dbf4-dependent kinase and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosis.

    Science.gov (United States)

    Princz, Lissa N; Wild, Philipp; Bittmann, Julia; Aguado, F Javier; Blanco, Miguel G; Matos, Joao; Pfander, Boris

    2017-03-01

    DNA repair by homologous recombination is under stringent cell cycle control. This includes the last step of the reaction, disentanglement of DNA joint molecules (JMs). Previous work has established that JM resolving nucleases are activated specifically at the onset of mitosis. In case of budding yeast Mus81-Mms4, this cell cycle stage-specific activation is known to depend on phosphorylation by CDK and Cdc5 kinases. Here, we show that a third cell cycle kinase, Cdc7-Dbf4 (DDK), targets Mus81-Mms4 in conjunction with Cdc5-both kinases bind to as well as phosphorylate Mus81-Mms4 in an interdependent manner. Moreover, DDK-mediated phosphorylation of Mms4 is strictly required for Mus81 activation in mitosis, establishing DDK as a novel regulator of homologous recombination. The scaffold protein Rtt107, which binds the Mus81-Mms4 complex, interacts with Cdc7 and thereby targets DDK and Cdc5 to the complex enabling full Mus81 activation. Therefore, Mus81 activation in mitosis involves at least three cell cycle kinases, CDK, Cdc5 and DDK Furthermore, tethering of the kinases in a stable complex with Mus81 is critical for efficient JM resolution. © 2017 The Authors. Published under the terms of the CC BY NC ND 4.0 license.

  15. North American Amphibian Monitoring Program (NAAMP) anuran detection data from the eastern and central United States (1994-2015)

    Science.gov (United States)

    Foreman, Tasha M.; Grant, Evan H. Campbell; Weir, Linda A.

    2017-01-01

    The North American Amphibian Monitoring Program (NAAMP) was a collaborative citizen science effort between the US Geological Survey (USGS) and 26 Partners (state agencies, universities, and nonprofits) for monitoring calling amphibian populations over much of the eastern and central United States. Initiated in 1997 in response to needs set forth by the Declining Amphibian Populations Task Force in 1994 regarding increased anecdotal observations of global amphibian declines, NAAMP was designed to provide scientifically and statistically defensible, long-term distribution and trends data for calling amphibian populations at the state and regional level in the United States. The USGS discontinued coordination of the program at the conclusion of the 2015 field season. Modeled after the USGS Breeding Bird Survey, NAAMP used a network of random and state-requested non-random roadside routes with listening stops near wetlands to collect frog and toad occupancy and environmental data in predominantly unprotected lands. Data collection and verification under a unified protocol began in 2001 and continued through 2015 with the addition of observer assessment scores in 2006. The USGS utilized verified 2001-2015 data from random routes to produce occupancy trend reports for anuran species of the Northeast, Southeast, and Midwest regions and states of the United States. This dataset includes all raw, verified NAAMP data from 1997 through 2015 and also raw, verified data from Partner States that precede the program (1994-1996). Data preceding 2001 followed variations of the unified protocol. Please refer to metadata for additional information regarding protocol and a list of the represented states and see the Species.csv file for the list of 58 represented species.

  16. The role of AtMUS81 in interference-insensitive crossovers in A. thaliana.

    Directory of Open Access Journals (Sweden)

    Luke E Berchowitz

    2007-08-01

    Full Text Available MUS81 is conserved among plants, animals, and fungi and is known to be involved in mitotic DNA damage repair and meiotic recombination. Here we present a functional characterization of the Arabidopsis thaliana homolog AtMUS81, which has a role in both mitotic and meiotic cells. The AtMUS81 transcript is produced in all tissues, but is elevated greater than 9-fold in the anthers and its levels are increased in response to gamma radiation and methyl methanesulfonate treatment. An Atmus81 transfer-DNA insertion mutant shows increased sensitivity to a wide range of DNA-damaging agents, confirming its role in mitotically proliferating cells. To examine its role in meiosis, we employed a pollen tetrad-based visual assay. Data from genetic intervals on Chromosomes 1 and 3 show that Atmus81 mutants have a moderate decrease in meiotic recombination. Importantly, measurements of recombination in a pair of adjacent intervals on Chromosome 5 demonstrate that the remaining crossovers in Atmus81 are interference sensitive, and that interference levels in the Atmus81 mutant are significantly greater than those in wild type. These data are consistent with the hypothesis that AtMUS81 is involved in a secondary subset of meiotic crossovers that are interference insensitive.

  17. Il musée du quai Branly, dialogo interculturale o monologo autoreferenziale?

    Directory of Open Access Journals (Sweden)

    Adriana Colombini Mantovani

    2011-03-01

    Full Text Available The Musée du Quai Branly features ethnological findings from four continents: Africa, Asia, Oceania and the Americas. Today scholars and experts are still debating whether in this particular museum/institution the aesthetic concern should prevail - allowing visitors to relate to the works without additional knowledge - or whether more complete and updated anthropological references should be provided.

  18. A Comparative Analysis of Gene Expression Profiles during Skin Regeneration in Mus and Acomys.

    Directory of Open Access Journals (Sweden)

    Jason Orr Brant

    Full Text Available The African spiny mouse (Acomys spp. can heal full thickness excisional skin wounds in a scar-free manner with regeneration of all dermal components including hair and associated structures. Comparing Acomys scar-free healing from Mus scarring identifies gene expression differences that discriminate these processes. We have performed an extensive comparison of gene expression profiles in response to 8mm full-thickness excisional wounds at days 3, 5, 7 and 14 post-wounding between Acomys and Mus to characterize differences in wound healing, and identify mechanisms involved in scar-free healing. We also identify similarities with scar-free healing observed in fetal wounds. While wounding in Mus elicits a strong inflammatory response, wounding in Acomys produces a moderated immune response and little to no increase in expression for most cytokines and chemokines assayed. We also identified differences in the ECM profiles of the Acomys wounds, which appear to have a collagen profile more similar to fetal wounds, with larger increases in expression of collagen types III and V. In contrast, Mus wounds have very high levels of collagen XII. This data suggests that an overall lack of induction of cytokines and chemokines, coupled with an ECM profile more similar to fetal wounds, may underlie scar-free wound healing in Acomys skin. These data identify candidate genes for further testing in order to elucidate the causal mechanisms of scar-free healing.

  19. A Comparative Analysis of Gene Expression Profiles during Skin Regeneration in Mus and Acomys.

    Science.gov (United States)

    Brant, Jason Orr; Lopez, Maria-Cecilia; Baker, Henry V; Barbazuk, W Brad; Maden, Malcolm

    2015-01-01

    The African spiny mouse (Acomys spp.) can heal full thickness excisional skin wounds in a scar-free manner with regeneration of all dermal components including hair and associated structures. Comparing Acomys scar-free healing from Mus scarring identifies gene expression differences that discriminate these processes. We have performed an extensive comparison of gene expression profiles in response to 8mm full-thickness excisional wounds at days 3, 5, 7 and 14 post-wounding between Acomys and Mus to characterize differences in wound healing, and identify mechanisms involved in scar-free healing. We also identify similarities with scar-free healing observed in fetal wounds. While wounding in Mus elicits a strong inflammatory response, wounding in Acomys produces a moderated immune response and little to no increase in expression for most cytokines and chemokines assayed. We also identified differences in the ECM profiles of the Acomys wounds, which appear to have a collagen profile more similar to fetal wounds, with larger increases in expression of collagen types III and V. In contrast, Mus wounds have very high levels of collagen XII. This data suggests that an overall lack of induction of cytokines and chemokines, coupled with an ECM profile more similar to fetal wounds, may underlie scar-free wound healing in Acomys skin. These data identify candidate genes for further testing in order to elucidate the causal mechanisms of scar-free healing.

  20. Musée ideale : unistused täiuslikust muuseumist / Mariann Raisma

    Index Scriptorium Estoniae

    Raisma, Mariann, 1974-

    2008-01-01

    18.-19. sajandi unistusi täiuslikust muuseumist kolmel tasandil: vormi ehk arhitektuuri, muuseumikogu terviklikkuse ning pärandi kättesaadavuse kaudu. Pikemalt Napoleon Bonaparte'ile pühendatud Musée Napoleoni kogudest, kontseptsioonist ja koopiamuuseumidest Lääne-Euroopas ning Tartus

  1. Twilight and Photoperiod Affect Behavioral Entrainment in the House Mouse (Mus musculus)

    NARCIS (Netherlands)

    Comas, M.; Hut, R. A.

    2009-01-01

    The effect of twilight transitions on entrainment of C57BL/6JOlaHsd mice (Mus musculus) was studied using light-dark cycles of different photoperiods (6, 12, and 18 h) and twilight transitions of different durations (0, 1, and 2 h). Phase angle differences of the onset, center of gravity, and offset

  2. The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks.

    Science.gov (United States)

    Hanada, Katsuhiro; Budzowska, Magda; Davies, Sally L; van Drunen, Ellen; Onizawa, Hideo; Beverloo, H Berna; Maas, Alex; Essers, Jeroen; Hickson, Ian D; Kanaar, Roland

    2007-11-01

    Faithful duplication of the genome requires structure-specific endonucleases such as the RuvABC complex in Escherichia coli. These enzymes help to resolve problems at replication forks that have been disrupted by DNA damage in the template. Much less is known about the identities of these enzymes in mammalian cells. Mus81 is the catalytic component of a eukaryotic structure-specific endonuclease that preferentially cleaves branched DNA substrates reminiscent of replication and recombination intermediates. Here we explore the mechanisms by which Mus81 maintains chromosomal stability. We found that Mus81 is involved in the formation of double-strand DNA breaks in response to the inhibition of replication. Moreover, in the absence of chromosome processing by Mus81, recovery of stalled DNA replication forks is attenuated and chromosomal aberrations arise. We suggest that Mus81 suppresses chromosomal instability by converting potentially detrimental replication-associated DNA structures into intermediates that are more amenable to DNA repair.

  3. Radial artery applanation tonometry for continuous noninvasive arterial blood pressure monitoring in the cardiac intensive care unit.

    Science.gov (United States)

    Langwieser, Nicolas; Prechtl, Luisa; Meidert, Agnes S; Hapfelmeier, Alexander; Bradaric, Christian; Ibrahim, Tareq; Laugwitz, Karl-Ludwig; Schmid, Roland M; Wagner, Julia Y; Saugel, Bernd

    2015-06-01

    Hemodynamic monitoring plays a pivotal role in the treatment of patients in the cardiac intensive care unit (CICU). The innovative radial artery applanation tonometry technology allows for continuous noninvasive arterial blood pressure (AP) measurement. By closing the gap between continuous invasive AP monitoring (arterial catheter) and intermittent noninvasive AP monitoring (oscillometry) this technology might improve CICU patient monitoring. We therefore aimed to evaluate the measurement performance of radial artery applanation tonometry in comparison with a radial arterial catheter in CICU patients. In this prospective method comparison study, we simultaneously recorded AP noninvasively with radial artery applanation tonometry (T-line 200 pro device; Tensys Medical Inc., San Diego, CA, USA) and invasively with an arterial catheter (criterion standard) in 30 patients treated in the CICU of a German university hospital. We statistically analyzed 7,304 averaged 10-beat epochs of measurements of mean AP, systolic AP, and diastolic AP by using Bland-Altman analysis for repeated measurements. Our study revealed a mean difference ± standard deviation (95% limits of agreement; percentage error) between radial artery applanation tonometry and the criterion standard method (radial arterial catheter) of +2 ± 6 mmHg (-10 to +14 mmHg; 17%) for mean AP, -6 ± 11 mmHg (-28 to +15 mmHg; 20%) for systolic AP, and +4 ± 7 mmHg (-9 to +17 mmHg; 23%) for diastolic AP. In CICU patients, continuous noninvasive measurement of AP using radial artery applanation tonometry is feasible. The technology showed reasonable accuracy and precision in comparison with radial arterial catheter-derived AP values.

  4. CHIPS: A New Way to Monitor Colonias Along the United States-Mexico Border

    Science.gov (United States)

    Parcher, Jean W.; Humberson, Delbert G.

    2007-01-01

    Colonias, which are unincorporated border settlements in the United States, have emerged in rural areas without the governance and services normally provided by local government. Colonia residents live in poverty and lack adequate health care, potable water, and sanitation systems. These conditions create substantial health risks for colonias and surrounding communities. By 2001, more than 1,400 colonias were identified in Texas. Cooperation with the U.S. Department of Housing and Urban Development, Offices of the Texas Attorney General, Secretary of State, and the Texas Water Development Board has allowed the U.S. Geological Survey (USGS) to improve colonia Geographic Information System (GIS) boundaries and develop the Colonia Health, Infrastructure, and Platting Status tool (CHIPS). Together, the GIS boundaries and CHIPS aid the Texas government in prioritizing the limited funds that are available for infrastructure improvement. CHIPS's report generator can be tailored to the needs of the user, providing either broad or specific output. For example, a congressman could use CHIPS to list colonias with wastewater issues in a specific county, whereas a health researcher could list all colonias without clinical access. To help cities along the United States-Mexico border manage issues related to colonias growth, CHIPS will become publicly available in an Internet-enabled GIS as part of a cooperative study between the USGS, the U.S. Department of Housing and Urban Development, and the Mexican Instituto Nacional de Estadistica Geografia e Informatica.

  5. Implantation and monitoring of a novel telemetry unit in the Syrian golden hamster model.

    Science.gov (United States)

    Garver, Jennifer; Bermeo-Blanco, Oscar A; Gibson, Neil; Bogie, Heather; Grenwis, Jessica; Vela, Eric M

    2012-06-01

    Radiotelemetry allows for real-time remote monitoring of biological parameters in freely moving laboratory animals. The HD-X11 transmitter is a novel telemetry device that enables simultaneous collection of body temperature, activity, blood pressure, electrocardiogram (ECG), and other biopotentials in small animal models. Previously, researchers could only collect either blood pressure or ECG parameters; prioritizing the signal of most interest or increasing the number of animals on study to capture both signals at one time. This new device eliminates the need for separate animal groups for assorted measurements and allows for a more complete cardiovascular assessment. Evaluation of the transmitter from both surgical and data collection perspectives indicates that the HD-X11 transmitter can be a useful tool to researchers in a wide range of scientific and medical fields.

  6. Atmospheric Ammonia and Particulate Inorganic Nitrogen Monitoring in the United States - A Comparison Study

    Science.gov (United States)

    Kariyawasam, T.

    2016-12-01

    Due to emission by disproportionately high livestock numbers and increased nitrogen fertilization, Ammonia (NH3) has come to play an increasingly important role in the global biogeochemical cycle of reactive nitrogen as well as in secondary aerosol formation and climate. Because of the public health problems it causes and the effects on the atmosphere, monitoring the global distribution of NH3 sources becomes crucial. Accurate measurements of atmospheric NH3 via ground level sensors and satellites are fundamentally essential for meteorological forecasting, hazard warning and various other applications. Since the NH3 retrieval quality is affected by meteorological properties, such as the vertical temperature, water vapor profiles, surface temperatures, and emissivity, which are used to model the atmosphere, even though satellite systems has the capability of monitoring environmental variables with high temporal and spatial coverages, they lack precision at or near ground level. Due to cost of implementation and technical maintenance constraints, daily global coverage of accurate NH3 in situ measurements from ground based sensors is also often limited in spatial representation. In research related to climate and atmospheric physics, the advances in sensor technology have led to the use of automated sensors in a variety of climate and atmospheric data analysis applications. The extant research is expanding further but lacks a framework to consider the current and future trends, gaps, challenges and opportunities. This research will attempt to provide insight into key capabilities of the current and potential future approaches and will present a framework to better understand NH3 research with the use of in - situ as well as remote sensors in detecting NH3 in the ambient atmosphere.

  7. Integrated Use Of MERIS And Other EO Data For Water Quality And Red Tide Monitoring Along United Arab Emirates Coasts

    Science.gov (United States)

    Ceriola, G.; Avgikou, V.; Manunta, P.

    2013-12-01

    Coastal zones host a large percentage of global population and economical and productive activities and are in need of a constant monitoring. The C-wams project is focused at implementing a suite EO services targeting two growing sectors: Waste Water Treatment and Desalination plants. The coast of the United Arab Emirates (UAE) hosts some of the largest desalination plants in the world and their operation can affect and be affected by the status of the WQ near the coast: the local phenomenon known as Red Tide caused increasing damages in the last 4 years. Some actors are involved in this respect in the Persian gulf, among them the Environment Agency of Abu Dhabi (EAD). In UAE an historical study-case is being performed aimed at identifying Red Tide events using MERIS images, integrating them with other medium and higher resolution data. The present work describes its scenario and the preliminary results obtained.

  8. Microorganisms in Confined Habitats: Microbial Monitoring and Control of Intensive Care Units, Operating Rooms, Cleanrooms and the International Space Station.

    Science.gov (United States)

    Mora, Maximilian; Mahnert, Alexander; Koskinen, Kaisa; Pausan, Manuela R; Oberauner-Wappis, Lisa; Krause, Robert; Perras, Alexandra K; Gorkiewicz, Gregor; Berg, Gabriele; Moissl-Eichinger, Christine

    2016-01-01

    Indoor environments, where people spend most of their time, are characterized by a specific microbial community, the indoor microbiome. Most indoor environments are connected to the natural environment by high ventilation, but some habitats are more confined: intensive care units, operating rooms, cleanrooms and the international space station (ISS) are extraordinary living and working areas for humans, with a limited exchange with the environment. The purposes for confinement are different: a patient has to be protected from infections (intensive care unit, operating room), product quality has to be assured (cleanrooms), or confinement is necessary due to extreme, health-threatening outer conditions, as on the ISS. The ISS represents the most secluded man-made habitat, constantly inhabited by humans since November 2000 - and, inevitably, also by microorganisms. All of these man-made confined habitats need to be microbiologically monitored and controlled, by e.g., microbial cleaning and disinfection. However, these measures apply constant selective pressures, which support microbes with resistance capacities against antibiotics or chemical and physical stresses and thus facilitate the rise of survival specialists and multi-resistant strains. In this article, we summarize the available data on the microbiome of aforementioned confined habitats. By comparing the different operating, maintenance and monitoring procedures as well as microbial communities therein, we emphasize the importance to properly understand the effects of confinement on the microbial diversity, the possible risks represented by some of these microorganisms and by the evolution of (antibiotic) resistances in such environments - and the need to reassess the current hygiene standards.

  9. Microorganisms in confined habitats: Microbial monitoring and control of intensive care units, operating rooms, cleanrooms and the International Space Station

    Directory of Open Access Journals (Sweden)

    Maximilian Mora

    2016-10-01

    Full Text Available Indoor environments, where people spend most of their time, are characterized by a specific microbial community, the indoor microbiome. Most indoor environments are connected to the natural environment by high ventilation, but some habitats are more confined: intensive care units, operating rooms, cleanrooms and the international space station (ISS are extraordinary living and working areas for humans, with a limited exchange with the environment. The purposes for confinement are different: a patient has to be protected from infections (intensive care unit, operating room, product quality has to be assured (cleanrooms, or confinement is necessary due to extreme, health-threatening outer conditions, as on the ISS. The ISS represents the most secluded man-made habitat, constantly inhabited by humans since November 2000 – and, inevitably, also by microorganisms. All of these man-made confined habitats need to be microbiologically monitored and controlled, by e.g. microbial cleaning and disinfection. However, these measures apply constant selective pressures, which support microbes with resistance capacities against antibiotics or chemical and physical stresses and thus facilitate the rise of survival specialists and multi-resistant strains. In this article, we summarize the available data on the microbiome of aforementioned confined habitats. By comparing the different operating, maintenance and monitoring procedures as well as microbial communities therein, we emphasize the importance to properly understand the effects of confinement on the microbial diversity, the possible risks represented by some of these microorganisms and by the evolution of (antibiotic resistances in such environments - and the need to reassess the current hygiene standards.

  10. Fraksi Heksan dan Fraksi Metanol Ekstrak Biji Pepaya Muda Menghambat Spermatogonia Mencit (Mus Musculus Jantan

    Directory of Open Access Journals (Sweden)

    Bagus Komang Satriyasa

    2010-03-01

    Full Text Available To avoid population booming, family planning program should be maintained in which menand woman have the same rights and obligations. However in execution of family planning the roleof men is still low. Studies about contraception in men are limited. Male contraception that isknown in society are condom and vasectomy. In the recent few years in particular, researcheshave been refocused on investigating traditional plants as anti fertility. In use researches manyplants have been studied, including papaya seed. Some researches on herbal anti fertility propertiesof papaya seed have been carried out including those on the active compounds of anti fertility, onapprolaki-lakite dosage of extract of carica papaya seed by animal experiments. Hexane fraction ofunripe papaya seed extract contains glycosides, alkaloid and triterpenoids, which is assumed hasan antifertility effect, so it can be used as a male contraceptive, although the mechanism of actionis not yet clear. Research is conducted at Animal Laboratory Unit Department of PharmacologyFaculty of Medicine University of Udayana, and Laboratorium Patologi Balai Penyidikan danPengujian Veterian (BPPV Wilayah VI Denpasar Direktorat Jenderal Peternakan, DepartmentPertanian. This study used the pre-test and post-test control group design, using 30 male mice ofbalb C strain, aged 12 weeks, weight 20-22 gram, subsequently grouped by random into 3 groupseach consisting of 10 male mice. One control group (P0 = control group was given double distilledwater, and two treatment groups (P1 = treatment group was given fraction of the hexane extractof young Carica papaya seed 20 mg/20gram Body wieght/day, (P2 = treatment group was givenfraction of the methanol extract of young Carica papaya seed 20 mg/20 gram/day. After 36 days oftreatment, evaluation of the testis, of the male mice was conducted. Data were analysed by normalitytest of Shapiro-will, homogeneity test, and Anova test. This study showed that cells of

  11. A Wearable Inertial Measurement Unit for Long-Term Monitoring in the Dependency Care Area

    Directory of Open Access Journals (Sweden)

    Andreu Català

    2013-10-01

    Full Text Available Human movement analysis is a field of wide interest since it enables the assessment of a large variety of variables related to quality of life. Human movement can be accurately evaluated through Inertial Measurement Units (IMU, which are wearable and comfortable devices with long battery life. The IMU’s movement signals might be, on the one hand, stored in a digital support, in which an analysis is performed a posteriori. On the other hand, the signal analysis might take place in the same IMU at the same time as the signal acquisition through online classifiers. The new sensor system presented in this paper is designed for both collecting movement signals and analyzing them in real-time. This system is a flexible platform useful for collecting data via a triaxial accelerometer, a gyroscope and a magnetometer, with the possibility to incorporate other information sources in real-time. A µSD card can store all inertial data and a Bluetooth module is able to send information to other external devices and receive data from other sources. The system presented is being used in the real-time detection and analysis of Parkinson’s disease symptoms, in gait analysis, and in a fall detection system.

  12. Solid Waste Management Units And Areas Of Concern Annual Long-Term Monitoring & Maintenance Report For Calendar Year 2016.

    Energy Technology Data Exchange (ETDEWEB)

    Dotson, Patrick Wells [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Little, Bonnie Colleen [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-02-01

    Long-term controls were maintained at 21 Solid Waste Management Units (SWMUs) and Areas of Concern (AOCs) in accordance with the requirements of the “Long-Term Monitoring and Maintenance Plan for SWMUs and AOCs Granted Corrective Action Complete with Controls” in Attachment M of the Resource Conservation and Recovery Act Facility Operating Permit, which took effect February 26, 2015. Maintenance and controls at these SWMUs and AOCs are described and documented in this report. Conditions requiring maintenance or repair activities were not identified for any of the inspected SWMUs or AOCs. Based upon the inspections performed and site conditions observed, the administrative and physical institutional controls in place at the SWMUs and AOCs are effectively providing continued protection of human health and the environment. This report does not present monitoring and maintenance activities for SWMU 76, the Mixed Waste Landfill; those activities adhere to the approved MWL LTMM Plan, Section 4.8.1 requiring a separate annual report which will be submitted to the NMED by June 30, 2017.

  13. A Technical Evaluation of Wireless Connectivity from Patient Monitors to an Anesthesia Information Management System During Intensive Care Unit Surgery.

    Science.gov (United States)

    Simpao, Allan F; Galvez, Jorge A; England, W Randall; Wartman, Elicia C; Scott, James H; Hamid, Michael M; Rehman, Mohamed A; Epstein, Richard H

    2016-02-01

    Surgical procedures performed at the bedside in the neonatal intensive care unit (NICU) at The Children's Hospital of Philadelphia were documented using paper anesthesia records in contrast to the operating rooms, where an anesthesia information management system (AIMS) was used for all cases. This was largely because of logistical problems related to connecting cables between the bedside monitors and our portable AIMS workstations. We implemented an AIMS for documentation in the NICU using wireless adapters to transmit data from bedside monitoring equipment to a portable AIMS workstation. Testing of the wireless AIMS during simulation in the presence of an electrosurgical generator showed no evidence of interference with data transmission. Thirty NICU surgical procedures were documented via the wireless AIMS. Two wireless cases exhibited brief periods of data loss; one case had an extended data gap because of adapter power failure. In comparison, in a control group of 30 surgical cases in which wired connections were used, there were no data gaps. The wireless AIMS provided a simple, unobtrusive, portable alternative to paper records for documenting anesthesia records during NICU bedside procedures.

  14. Can we improve the early detection of atrial fibrillation in a stroke unit? Detection rate of a monitor with integrated detection software.

    Science.gov (United States)

    Arevalo-Manso, Juan Jose; Martínez-Sánchez, Patricia; Fuentes, Blanca; Ruiz-Ares, Gerardo; Sanz-Cuesta, Borja Enrique; Prefasi, Daniel; Juarez-Martin, Belén; Navarro-Parias, Azahara; Parrilla-Novo, Pilar; Diez-Tejedor, Exuperio

    2016-02-01

    It is unknown whether monitors that include atrial fibrillation recognition software (AF-RS) increase the rate of early atrial fibrillation (AF) detection in acute stroke. We aimed to evaluate the AF detection rate of an AF-RS monitor and compare it with standard monitoring. This was a retrospective, single-centre observational study conducted on consecutive patients with acute transient ischaemic attack or brain infarction attended in a stroke unit (SU) with six beds. Five beds had a standard monitor with a three-lead electrocardiogram (ECG)-tracing monitor that did not automatically detect AF, and one bed had a 12-lead ECG monitor with integrated AF-RS. All patients were monitored for at least 24 h and underwent a daily ECG during their stay in the SU. In case of unknown stroke aetiology, the patients underwent 24 h Holter monitoring. A total of 76 patients were included: 59 patients in the standard monitor group and 17 patients in the AF-RS monitor group. The mean age was 72.11 (±13.09) years, and 59.2% were men. A total of 20 new cases of AF were identified. The AF-RS monitor showed a higher rate of AF detection than the standard devices (57.1% vs 7.7%, p=0.031). The AF-RS monitor showed sensitivity, specificity, positive predictive value, and negative predictive values of 57.1%, 100%, 100% and 76.9%, respectively. For the standard monitors, these values were 7.7%, 100%, 100% and 79.3%, respectively. The monitor with AF-RS demonstrated a higher detection rate for AF than standard ECG monitoring in acute stroke patients in a SU. © The European Society of Cardiology 2014.

  15. Hand disinfection in a neonatal intensive care unit: continuous electronic monitoring over a one-year period

    Directory of Open Access Journals (Sweden)

    Helder Onno K

    2012-10-01

    Full Text Available Abstract Background Good hand hygiene compliance is essential to prevent nosocomial infections in healthcare settings. Direct observation of hand hygiene compliance is the gold standard but is time consuming. An electronic dispenser with built-in wireless recording equipment allows continuous monitoring of its usage. The purpose of this study was to monitor the use of alcohol-based hand rub dispensers with a built-in electronic counter in a neonatal intensive care unit (NICU setting and to determine compliance with hand hygiene protocols by direct observation. Methods A one-year observational study was conducted at a 27 bed level III NICU at a university hospital. All healthcare workers employed at the NICU participated in the study. The use of bedside dispensers was continuously monitored and compliance with hand hygiene was determined by random direct observations. Results A total of 258,436 hand disinfection events were recorded; i.e. a median (interquartile range of 697 (559–840 per day. The median (interquartile range number of hand disinfection events performed per healthcare worker during the day, evening, and night shifts was 13.5 (10.8 - 16.7, 19.8 (16.3 - 24.1, and 16.6 (14.2 - 19.3, respectively. In 65.8% of the 1,168 observations of patient contacts requiring hand hygiene, healthcare workers fully complied with the protocol. Conclusions We conclude that the electronic devices provide useful information on frequency, time, and location of its use, and also reveal trends in hand disinfection events over time. Direct observations offer essential data on compliance with the hand hygiene protocol. In future research, data generated by the electronic devices can be supplementary used to evaluate the effectiveness of hand hygiene promotion campaigns.

  16. Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells.

    Science.gov (United States)

    Wyatt, Haley D M; Sarbajna, Shriparna; Matos, Joao; West, Stephen C

    2013-10-24

    Holliday junctions (HJs) are four-way DNA intermediates that form during homologous recombination, and their efficient resolution is essential for chromosome segregation. Here, we show that three structure-selective endonucleases, namely SLX1-SLX4, MUS81-EME1, and GEN1, define two pathways of HJ resolution in human cells. One pathway is mediated by GEN1, whereas SLX1-SLX4 and MUS81-EME1 provide a second and genetically distinct pathway (SLX-MUS). Cells depleted for SLX-MUS or GEN1 pathway proteins exhibit severe defects in chromosome segregation and reduced survival. In response to CDK-mediated phosphorylation, SLX1-SLX4 and MUS81-EME1 associate at the G2/M transition to form a stable SLX-MUS holoenzyme, which can be reconstituted in vitro. Biochemical studies show that SLX-MUS is a HJ resolvase that coordinates the active sites of two distinct endonucleases during HJ resolution. This cleavage reaction is more efficient and orchestrated than that mediated by SLX1-SLX4 alone, which exhibits a potent nickase activity that acts promiscuously upon DNA secondary structures. Copyright © 2013 Elsevier Inc. All rights reserved.

  17. Gravity Monitoring of Ground-Water Storage Change in the Southwestern United States

    Science.gov (United States)

    Winester, D.; Pool, D. R.; Schmerge, D. L.; Hoffmann, J. P.; Keller, G. R.

    2004-12-01

    Repeat measurements of absolute gravity have been made since 1998 to estimate changes in ground-water mass as part of ground-water budget estimates in arid and semiarid regions of the Southwestern United States. The absolute acceleration of gravity is measured twice each year at 16 stations to an accuracy of about plus or minus 2 microGal, or about 5 cm of water. Observations are normally done for the purpose of providing gravity control for relative gravity surveys of networks of stations across wider areas. Other data incorporated into the ground-water budget estimates include precipitation, water levels, moisture content in the unsaturated zone, surface water runoff, and ellipsoid heights using the Global Positioning System (GPS). Gravity and water-level changes are correlated for stations measured in the Basin and Range Physiographic Province near Tucson, Phoenix, Casa Grande, and Sierra Vista, Arizona. Decreasing gravity and water levels in the Tucson area since the summer of 1998 are likely related to predominant drought conditions and decreases in ground-water storage following above average winter precipitation and recharge during the El Nino of 1998. Increases in gravity at stations in the upper and middle Verde Valley Watershed in central Arizona since the fall of 2000 do not correlate well with declining streamflows and water levels and may be caused by temporary increases in soil moisture following wet winters. There have been no significant observed gravity changes at two stations in the El Paso, Texas, area since the initial observations during the summer of 2003, even though ground-water pumping in the area has been heavy.

  18. Application of synthetic aperture radar interferometry for mine subsidence monitoring in the western United States

    Science.gov (United States)

    Wempen, Jessica Michelle

    Differential Interferometric Synthetic Aperture Radar (DInSAR), a satellite-based remote sensing technique, is a practical method for measuring deformation of the earth's surface. In this investigation, the application of DInSAR for monitoring mine subsidence was evaluated for active underground mining regions in the Green River Basin in southwest Wyoming and the Wasatch Plateau in central Utah. Interferograms were generated using X-band (3-cm wavelength) Synthetic Aperture Radar data from the TerraSAR-X mission and L-band (24-cm wavelength) Synthetic Aperture Radar data from the Advanced Land Observing Satellite. In general, the DInSAR data have high spatial and temporal resolutions and show gradual, progressive subsidence. In the Green River Basin, displacements were estimated using both L-band and X-band data. In the Wasatch Plateau, displacements were only estimated using L-band data; areas affected by subsidence are identifiable in the X-band data, but precisely quantifying subsidence magnitudes is difficult as a result of significant phase noise. In the Green River Basin, the maximum subsidence magnitude was 150 cm over 690 days, estimated using L-band DInSAR. In the Wasatch Plateau, the maximum subsidence magnitude was 180 cm over 414 days. In both regions, as a result of low coherence in the areas with large displacements, the maximum displacements may be underestimated by tens of centimeters. Additionally, relationships between surface deformations measured by DInSAR and mining-induced seismicity (MIS) in the Green River Basin and the Wasatch Plateau were explored. Both regions exhibit large magnitude, relatively rapid subsidence, but the characteristics (rates and magnitudes) of MIS in the Wasatch Plateau study region and the Green River Basin are significantly different. In the Wasatch Plateau study region, surface displacements tend to precede seismicity, event rates tend to be high, and event magnitudes tend to be relatively low. In the Green River

  19. Prioritization of constituents for national- and regional-scale ambient monitoring of water and sediment in the United States

    Science.gov (United States)

    Olsen, Lisa D.; Valder, Joshua F.; Carter, Janet M.; Zogorski, John S.

    2013-01-01

    A total of 2,541 constituents were evaluated and prioritized for national- and regional-scale ambient monitoring of water and sediment in the United States. This prioritization was done by the U.S. Geological Survey (USGS) in preparation for the upcoming third decade (Cycle 3; 2013–23) of the National Water-Quality Assessment (NAWQA) Program. This report provides the methods used to prioritize the constituents and the results of that prioritization. Constituents were prioritized by the NAWQA National Target Analyte Strategy (NTAS) work group on the basis of available information on physical and chemical properties, observed or predicted environmental occurrence and fate, and observed or anticipated adverse effects on human health or aquatic life. Constituents were evaluated within constituent groups that were determined on the basis of physical or chemical properties or on uses or sources. Some constituents were evaluated within more than one constituent group. Although comparable objectives were used in the prioritization of constituents within the different constituent groups, differences in the availability of information accessed for each constituent group led to the development of separate prioritization approaches adapted to each constituent group to make best use of available resources. Constituents were assigned to one of three prioritization tiers: Tier 1, those having the highest priority for inclusion in ambient monitoring of water or sediment on a national or regional scale (including NAWQA Cycle 3 monitoring) on the basis of their likelihood of environmental occurrence in ambient water or sediment, or likelihood of effects on human health or aquatic life; Tier 2, those having intermediate priority for monitoring on the basis of their lower likelihood of environmental occurrence or lower likelihood of effects on human health or aquatic life; and Tier 3, those having low or no priority for monitoring on the basis of evidence of nonoccurrence or lack of

  20. Monitoring conterminous United States (CONUS) land cover change with Web-Enabled Landsat Data (WELD)

    Science.gov (United States)

    Hansen, M.C.; Egorov, Alexey; Potapov, P.V.; Stehman, S.V.; Tyukavina, A.; Turubanova, S.A.; Roy, David P.; Goetz, S.J.; Loveland, T.R.; Ju, J.; Kommareddy, A.; Kovalskyy, Valeriy; Forsyth, C.; Bents, T.

    2014-01-01

    Forest cover loss and bare ground gain from 2006 to 2010 for the conterminous United States (CONUS) were quantified at a 30 m spatial resolution using Web-Enabled Landsat Data available from the USGS Center for Earth Resources Observation and Science (EROS) (http://landsat.usgs.gov/WELD.php). The approach related multi-temporal WELD metrics and expert-derived training data for forest cover loss and bare ground gain through a decision tree classification algorithm. Forest cover loss was reported at state and ecoregional scales, and the identification of core forests' absent of change was made and verified using LiDAR data from the GLAS (Geoscience Laser Altimetry System) instrument. Bare ground gain correlated with population change for large metropolitan statistical areas (MSAs) outside of desert or semi-desert environments. GoogleEarth™ time-series images were used to validate the products. Mapped forest cover loss totaled 53,084 km2 and was found to be depicted conservatively, with a user's accuracy of 78% and a producer's accuracy of 68%. Excluding errors of adjacency, user's and producer's accuracies rose to 93% and 89%, respectively. Mapped bare ground gain equaled 5974 km2 and nearly matched the estimated area from the reference (GoogleEarth™) classification; however, user's (42%) and producer's (49%) accuracies were much less than those of the forest cover loss product. Excluding errors of adjacency, user's and producer's accuracies rose to 62% and 75%, respectively. Compared to recent 2001–2006 USGS National Land Cover Database validation data for forest loss (82% and 30% for respective user's and producer's accuracies) and urban gain (72% and 18% for respective user's and producer's accuracies), results using a single CONUS-scale model with WELD data are promising and point to the potential for national-scale operational mapping of key land cover transitions. However, validation results highlighted limitations, some of which can be addressed by

  1. Control Of Motor Unit Firing During Step-Like Increases In Voluntary Force

    Directory of Open Access Journals (Sweden)

    Xiaogang eHu

    2014-09-01

    Full Text Available In most skeletal muscles, force is generated by a combination of motor unit (MU recruitment and increases in the firing rate of previously active MUs. Two contrasting patterns of firing rate organization have been reported. In the first pattern, the earliest recruited MUs reach the highest firing rates as force is increased, and later recruited MUs fire at lower rates. When firing rate of multiple MUs are superimposed, these rate trajectories form a concentric layered profile termed ‘onion skin’. In the second pattern, called ‘reverse onion skin’, later recruited MUs reach higher firing rates, and crossing of firing rate trajectories for recorded MUs is common (although such trajectories are assembled routinely from different trials. Our present study examined the firing rate organization of concurrently active MUs of the first dorsal interosseous muscle during serial, step-like increases in isometric abduction forces. We used a surface sensor array coupled with MU discrimination algorithms to characterize MU firing patterns. Our objective was to determine whether ‘onion skin’ profiles are contingent upon the force trajectory of the motor task, examined here using step-like increases of force output, and also whether they are manifested at different force levels.Our results revealed that the overall ‘onion skin’ firing rate profile was retained as the force level increased with each force step up to 15% MVC. However, the distribution of firing rates across MUs was compressed with increasing force, and overlapping firing rate of units were observed. This rate compression was largely due to rate saturation of the relatively high frequency discharging MUs.Our results reflect flexible firing patterns across MUs at different levels of excitation drive. It is also evident that many units did not follow all the step increases consistently. This failure to track firing rate increases at higher forces could be due to an intrinsically

  2. Monitoring of resistivity and IP: The Syscal Monitoring Unit (SMU), a new system dedicated for remote control of the Syscal Pro resistivimeter

    Science.gov (United States)

    Gance, Julien; Leite, Orlando; Texier, Benoît; Bernard, Jean; Truffert, Catherine

    2017-04-01

    All matter, gas, fluids and energy transfer at soil/atmosphere interface govern soil, rock and life evolution in the critical zone. Near surface electrical resistivity and chargeability modifications with time are distinguishable and process related enough for bringing to geoscientist relevant clue within this highly studied zone. Such non-invasive measurements are directly sensitive to a wide range of remarkable parameters (soil water content, temperature, soil water conductivity, clay content, etc.). In order to increase physical, chemical and biological processes understanding, resistivity and IP monitoring remain the less costly and the more powerful method among others. Indeed, these methods are the most suitable to image 2D/3D and 4D processes in an automated way. Whether such geophysical survey are for academic knowledge, waste landfill leakage or landslide monitoring purpose, it has to be done during medium to long period of time (from days to years). Nevertheless, operators don't need to be on site all the survey long. So, equipment manufacturers had to propose them suitable solutions for their needs. Syscal Pro resistivimeter is well adapted to observe the critical zone down to 100 m depth with its 10 channels and 250 watts. Its high speed recording (up to 1000 records/min) ability is also suited to apprehend expected kinetics of studied phenomena. In this context, IRIS Instruments developed a dedicated remote unit able to remote control Syscal Pro resistivimeter. It allows to change acquisition parameters (sequences), to check the main constant (battery levels, internal temperature) and to alert in case of any recording troubles. Data can be sent directly to FTP or SSH server or by mail for an easy and constant access to the data. Alert functionalities sent by mail in case of low battery or too many outliers present in the data are welcome to check the dimensioning of the energy source and for easily maintaining the long-term acquisition necessary for

  3. INTEGRAL/JEM-X detection of fading emission from GT Mus

    DEFF Research Database (Denmark)

    Fiocchi, M.; Chenevez, J.; Sguera, V.;

    2015-01-01

    On November 15th 2015 the MAXI/GSC detected a big flare from the RS CVn star GT Mus with a flux of ~100 mCrab in the 2-20 keV energy band. (ATel #8285). During recent INTEGRAL observations of the Musca region performed between 17 Nov 16:08 and 18 Nov 00:05 (UTC) the source GT Mus was within...... a 3 sigma upper limit of about 25 mCrab in the 18-40 keV energy range. In addition, INTEGRAL observed the Musca region on Nov 12 2015 between 11:14 and 17:11 (UTC) and the source was not significantly detected by JEM-X. We derive a 5-sigma upper limit of 4 mCrab (3-10 keV) for a net exposure time...

  4. Novel insights into maintaining genomic integrity: Wee1 regulating Mus81/Eme1

    Directory of Open Access Journals (Sweden)

    Martín Yusé

    2011-12-01

    Full Text Available Abstract Maintenance of genomic integrity is essential for cell survival. Specifically, during DNA replication cells use a complex network of mechanisms that prevents genomic instability. Recently, we and others identified Wee1, a serine/threonine and tyrosine kinase, as a new modulator of the genomic stability during S phase. Loss of its activity causes a general DNA damage response activation and a decrease in replication fork speed. These effects are counteracted by the downregulation of the endonuclease complex Mus81-Eme1, showing a new link between this endonuclease and Wee1 during DNA replication. Here we discuss the function of Wee1 in genomic stability and its relationship with the Mus81-Eme1 complex.

  5. An Approach for Simulation of the Muscle Force Modeling It by Summation of Motor Unit Contraction Forces

    Directory of Open Access Journals (Sweden)

    Rositsa Raikova

    2013-01-01

    Full Text Available Muscle force is due to the cumulative effect of repetitively contracting motor units (MUs. To simulate the contribution of each MU to whole muscle force, an approach implemented in a novel computer program is proposed. The individual contraction of an MU (the twitch is modeled by a 6-parameter analytical function previously proposed; the force of one MU is a sum of its contractions due to an applied stimulation pattern, and the muscle force is the sum of the active MUs. The number of MUs, the number of slow, fast-fatigue-resistant, and fast-fatigable MUs, and their six parameters as well as a file with stimulation patterns for each MU are inputs for the developed software. Different muscles and different firing patterns can be simulated changing the input data. The functionality of the program is illustrated with a model consisting of 30 MUs of rat medial gastrocnemius muscle. The twitches of these MUs were experimentally measured and modeled. The forces of the MUs and of the whole muscle were simulated using different stimulation patterns that included different regular, irregular, synchronous, and asynchronous firing patterns of MUs. The size principle of MUs for recruitment and derecruitment was also demonstrated using different stimulation paradigms.

  6. A Comparative Analysis of Gene Expression Profiles during Skin Regeneration in Mus and Acomys

    OpenAIRE

    Brant, Jason Orr; Lopez, Maria-Cecilia; Baker, Henry V.; Barbazuk, W. Brad; Maden, Malcolm

    2015-01-01

    The African spiny mouse (Acomys spp.) can heal full thickness excisional skin wounds in a scar-free manner with regeneration of all dermal components including hair and associated structures. Comparing Acomys scar-free healing from Mus scarring identifies gene expression differences that discriminate these processes. We have performed an extensive comparison of gene expression profiles in response to 8mm full-thickness excisional wounds at days 3, 5, 7 and 14 post-wounding between Acomys and ...

  7. SEM analysis of body hairs and whiskers of heterozygous tortoiseshell (Moto/+) female mice (Mus musculus).

    OpenAIRE

    Sheedlo, H J; Beck, M L

    1982-01-01

    Back hairs of +/+ and Moto/+ female Mus musculus generally exhibited identical form when examined by SEM. However, the hair shafts of Moto/+ female mice were beaded in appearance (monilethrix), twisted (pili torti) or exhibited a rough nodular appearance. Also, some hairs of Moto/+ female mice which were devoid of pigment appeared enlarged and bitubular. The whiskers of +/+ and Moto/+ female mice were identical in form. The hair abnormalities of Moto/+ female mice resulted from a copper defic...

  8. Monitoring the natural attenuation of petroleum in ground water at the former naval complex, Operable Unit A, Adak Island, Alaska, May and June 2003

    Science.gov (United States)

    Dinicola, R.S.; Simonds, F.W.; Defawe, Rose

    2005-01-01

    During May and June 2003, the U.S. Geological Survey installed monitoring wells and collected data to characterize the effectiveness of natural attenuation processes for remediating petroleum-contaminated ground water at Operable Unit A of the former Naval complex on Adak Island, Alaska. In addition, the evidence for petroleum biodegradation in ground water was evaluated at selected petroleum sites, plans for future natural attenuation monitoring were suggested for the selected petroleum sites, and the natural attenuation monitoring strategy for the Downtown area of Adak Island was reviewed and refinements were suggested. U.S. Geological Survey personnel measured water levels and collected ground-water samples from about 100 temporary boreholes and 50 monitoring wells. Most samples were analyzed on-site for concentrations of selected petroleum compounds and natural attenuation parameters such as dissolved oxygen, ferrous iron, and carbon dioxide. The U.S. Geological Survey evaluated the data on-site, selected new monitoring well locations, and installed, developed, and sampled 10 monitoring wells. The review and suggestions for the natural attenuation monitoring strategy focused on how to better achieve monitoring objectives specified in the Record of Decision for Adak Island petroleum sites. To achieve the monitoring objective of verifying that natural attenuation is occurring, the monitoring plans for each monitored natural attenuation site need to include sampling of at least one strategically placed well at the downgradient margin of the contaminant plume margin, preferably where contaminant concentrations are detectable but less than the cleanup level. Collection of natural attenuation parameter data and sampling background wells is no longer needed to achieve the monitoring objective of demonstrating the occurrence of natural attenuation. To achieve the objective of monitoring locations where chemical concentrations exceed specified cleanup levels, at least

  9. Estimating occupancy dynamics for large-scale monitoring networks: amphibian breeding occupancy across protected areas in the northeast United States

    Science.gov (United States)

    Miller, David A.W.; Grant, Evan H. Campbell

    2015-01-01

    Regional monitoring strategies frequently employ a nested sampling design where a finite set of study areas from throughout a region are selected within which intensive sub-sampling occurs. This sampling protocol naturally lends itself to a hierarchical analysis to account for dependence among sub-samples. Implementing such an analysis within a classic likelihood framework is computationally prohibitive with species occurrence data when accounting for detection probabilities. Bayesian methods offer an alternative framework to make this analysis feasible. We demonstrate a general approach for estimating occupancy when data come from a nested sampling design. Using data from a regional monitoring program of wood frogs (Lithobates sylvaticus) and spotted salamanders (Ambystoma maculatum) in vernal pools, we analyzed data using static and dynamic occupancy frameworks. We analyzed observations from 2004-2013collected within 14 protected areas located throughout the northeast United States . We use the data set to estimate trends in occupancy at both the regional and individual protected area level. We show that occupancy at the regional level was relatively stable for both species. Much more variation occurred within individual study areas, with some populations declining and some increasing for both species. We found some evidence for a latitudinal gradient in trends among protected areas. However, support for this pattern is overestimated when the hierarchical nature of the data collection is not controlled for in the analysis. For both species, occupancy appeared to be declining in the most southern areas, while occupancy was stable or increasing in more northern areas. These results shed light on the range-level population status of these pond-breeding amphibians and our approach provides a framework that can be used to examine drivers of change including among-year and among-site variation in occurrence dynamics, while properly accounting for nested structure of

  10. 40 CFR 75.81 - Monitoring of Hg mass emissions and heat input at the unit level.

    Science.gov (United States)

    2010-07-01

    ... cubic meter (µg/scm); and (2) A flow monitoring system; and (3) A continuous moisture monitoring system... Hg concentration monitoring system (as defined in § 72.2 of this chapter) or a sorbent trap monitoring system (as defined in § 72.2 of this chapter), to measure the mass concentration of total...

  11. An assessment of the performance of the Monitor for AeRosols and GAses in ambient air (MARGA: a semi-continuous method for soluble compounds

    Directory of Open Access Journals (Sweden)

    I. C. Rumsey

    2013-09-01

    Full Text Available Ambient air monitoring as part of the US Environmental Protection Agency's (US EPA's Clean Air Status and Trends Network (CASTNet currently uses filter packs to measure weekly integrated concentrations. The US EPA is interested in supplementing CASTNet with semi-continuous monitoring systems at select sites to characterize atmospheric chemistry and deposition of nitrogen and sulfur compounds at higher time resolution than the filter pack. The Monitor for AeRosols and GAses in ambient air (MARGA measures water-soluble gases and aerosols at hourly temporal resolution. The performance of the MARGA was assessed under the US EPA Environmental Technology Verification (ETV program. The assessment was conducted in Research Triangle Park, North Carolina from 8 September–8 October 2010 and focused on gaseous SO2, HNO3 and NH3 and aerosol SO4−, NO3− and NH4+. Precision of the MARGA was evaluated by calculating the median absolute relative percent difference (MARPD between paired hourly results from duplicate MARGA units (MUs, with a performance goal of 2, SO42− and NH4+, with all three compounds passing the accuracy and precision goals by a significant margin. The performance of the MARGA in measuring NO3− could not be evaluated due to the different sampling efficiency of coarse NO3− by the MUs and the filter pack. Estimates of "fine" NO3− were calculated for the MUs and the filter pack. Using this and results from a previous study, it is concluded that if the MUs and the filter pack were sampling the same particle size, the MUs would have good agreement in terms of precision and accuracy. The MARGA performed moderately well in measuring HNO3 and NH3, though neither met the linear regression slope goals. However, recommendations for improving the measurement of HNO3 and NH3 are discussed. It is concluded that SO42−, SO2, NO3−, HNO3, NH4+ and NH3 concentrations can be measured with acceptable accuracy and precision when the MARGA is

  12. Applications of the monitor of loose parts in the cycle 6 of the Laguna Verde Unit 2 power plant; Aplicaciones del monitor de partes sueltas en el ciclo 6 de la Unidad 2 de la central Laguna Verde

    Energy Technology Data Exchange (ETDEWEB)

    Calleros, G.; Mendez, A.; Gomez, R.A. [Comision Federal de Electricidad, Central Nucleoelectrica Laguna Verde, Veracruz (Mexico); Castillo, R.; Bravo, J.M. [ININ, A.P. 18-1027, 11801 Mexico D.F. (Mexico)]. E-mail: gcm9acpp@cfe.gob.mx

    2004-07-01

    The monitor of loose parts (Loose Parts Monitoring System) installed in the Unit 2 of the Laguna Verde Central is a tool to detect strange objects or parts loose in the system of refrigeration of the reactor that could be impacted in the walls of the recirculation knots or in the internal of the reactor. In this work two applications are shown carried out with the Monitor of Loose Parts, determining the characteristics of the stable nominal conditions, those which when changing, they are used to diagnose during the Cycle 6 of the Unit 2, failures in the components of the the recirculation circuits or to identify mechanical vibrations of the recirculation knots induced by a flow of recirculation bistable associated to operative conditions of the reactor. (Author)

  13. The strategy for improving water-quality monitoring in the United States; final report of the Intergovernmental Task Force on Monitoring Water Quality; technical appendices

    Science.gov (United States)

    ,

    1995-01-01

    The Intergovernmental Task Force on Monitoring Water Quality (ITFM) prepared this report in collaboration with representatives of all levels of government and the private sector. The report recommends a strategy for nationwide water-quality monitoring and technical monitoring improvements to support sound water-quality decisionmaking. The strategy is intended to achieve a better return on public and private investments in monitoring, environmental protection, and natural resources management. It is also designed to expand the base of information useful to a variety of users at multiple geographic scales. Institutional and technical changes are needed to improve water-quality monitoring and to meet the full range of monitoring requirements. Monitoring must be incorporated as a critical element of program planning, implementation, and evaluation. The strategy includes recommendations in many key elements, such as the development of goal-oriented monitoring and indicators, institutional collaboration, and methods comparability. Initial actions have been taken to implement the strategy. Several Federal agencies have jointly purchased and shared remotely sensed land-cover information needed for water assessment. Major agency data systems are using common data-element names and reference tables that will ensure easy sharing of data. A number of States have held meetings with collectors of water information to initiate statewide monitoring strategies. New monitoring guidance has been developed for Federal water-quality grants to States. Many State offices have changed monitoring programs to place emphasis on priority watersheds and to improve assessment of water quality. As the competition increases for adequate supplies of clean water, concerns about public health and the environment escalate, and more demands are placed on the water information infrastructure. To meet these demands, the collaborative approach has already produced benefits, which will continue to grow as

  14. Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe.

    Science.gov (United States)

    Sarbajna, Shriparna; Davies, Derek; West, Stephen C

    2014-05-15

    The resolution of recombination intermediates containing Holliday junctions (HJs) is critical for genome maintenance and proper chromosome segregation. Three pathways for HJ processing exist in human cells and involve the following enzymes/complexes: BLM-TopoIIIα-RMI1-RMI2 (BTR complex), SLX1-SLX4-MUS81-EME1 (SLX-MUS complex), and GEN1. Cycling cells preferentially use the BTR complex for the removal of double HJs in S phase, with SLX-MUS and GEN1 acting at temporally distinct phases of the cell cycle. Cells lacking SLX-MUS and GEN1 exhibit chromosome missegregation, micronucleus formation, and elevated levels of 53BP1-positive G1 nuclear bodies, suggesting that defects in chromosome segregation lead to the transmission of extensive DNA damage to daughter cells. In addition, however, we found that the effects of SLX4, MUS81, and GEN1 depletion extend beyond mitosis, since genome instability is observed throughout all phases of the cell cycle. This is exemplified in the form of impaired replication fork movement and S-phase progression, endogenous checkpoint activation, chromosome segmentation, and multinucleation. In contrast to SLX4, SLX1, the nuclease subunit of the SLX1-SLX4 structure-selective nuclease, plays no role in the replication-related phenotypes associated with SLX4/MUS81 and GEN1 depletion. These observations demonstrate that the SLX1-SLX4 nuclease and the SLX4 scaffold play divergent roles in the maintenance of genome integrity in human cells.

  15. Instrument-independent flux units for laser Doppler perfusion monitoring assessed in a multi-device study on the renal cortex

    NARCIS (Netherlands)

    Petoukhova, AL; Steenbergen, W; Morales, F; Graaff, R; de Jong, ED; Elstrodt, JM; de Mul, FFM; Rakhorst, G

    2003-01-01

    To investigate the feasibility of instrument-independent perfusion units for laser Doppler flowmetry, a comparison was performed of two commercial fiberoptic laser Doppler perfusion monitors measuring the same flux situation for two different types of probes. In vivo measurements were performed on t

  16. Efficacy of drugs against Giardia muris in mice Mus musculus naturally infected/ Eficácia de drogas contra Giardia muris em camundongos Mus musculus naturalmente infectados

    Directory of Open Access Journals (Sweden)

    Silvia Gonzalez Monteiro

    2008-08-01

    Full Text Available This study aimed to evaluate the efficacy of metronidazole, fenbendazole and secnidazole against Giardia muris in mice naturally infected. Forty mice of the species Mus musculus were divided in four groups of ten each, being group A non treated, the control group and groups B, C and D treated with 4mg/ml of metronidazole, fenbendazole and secnidazole, respectively. Two feces collection, on day 0 and on day 10 after treatment, were done in order to evaluate the efficacy of the drugs. Samples were analyzed by the centrifugal-flotation method with zinc sulfate. Efficacy of 97,05% for metronidazole, 98,30% for fenbendazole and 100% for secnidazole were observed in the study. According to the results it was concluded that the tested drugs were effective for the treatment of mice parasitized by Giardia muris.Este estudo visou avaliar a eficácia do metronidazol, fenbendazole e secnidazol contra Giardia muris em camundongos naturalmente infectados. Foram utilizados 40 camundongos da espécie Mus musculus divididos em quatro grupos de 10 animais cada, sendo grupo A, grupo controle, não tratados, e grupos B, C e D tratados com 4mg/ml de metronidazol, fenbendazole e secnidazol, respectivamente. Para avaliar a eficácia dos medicamentos foram realizadas duas coletas de fezes uma no dia zero e outra 10 dias após tratamento. As amostras foram processadas e analisadas a partir do método de centrífugo-flutuação com sulfato de zinco. No estudo observou-se eficácia de 97,05% para metronidazol, 98,30% para fenbendazole e 100% para secnidazol no tratamento de giardiase murina. Com base nos resultados concluí-se que as drogas testadas apresentaram eficácia no tratamento de camundongos parasitados por Giardia muris.

  17. 40 CFR 62.15265 - How do I monitor the load of my municipal waste combustion unit?

    Science.gov (United States)

    2010-07-01

    ... municipal waste combustion unit? 62.15265 Section 62.15265 Protection of Environment ENVIRONMENTAL... DESIGNATED FACILITIES AND POLLUTANTS Federal Plan Requirements for Small Municipal Waste Combustion Units... my municipal waste combustion unit? (a) If your municipal waste combustion unit generates steam, you...

  18. 40 CFR 60.1810 - How do I monitor the load of my municipal waste combustion unit?

    Science.gov (United States)

    2010-07-01

    ... municipal waste combustion unit? 60.1810 Section 60.1810 Protection of Environment ENVIRONMENTAL PROTECTION... Guidelines and Compliance Times for Small Municipal Waste Combustion Units Constructed on or Before August 30... combustion unit? (a) If your municipal waste combustion unit generates steam, you must install, calibrate...

  19. Comparison ecological characteristics of mound-building mouse (mus spicilegus in two natural hotbeds of tularemia at North-West coast of the Black sea

    Directory of Open Access Journals (Sweden)

    І. T. Rusev

    2011-03-01

    Full Text Available The analysis of ecology-epizootic monitoring of North-West coast of the Black sea carried out in wintering seasons of 2004, 2005 and 2011 testifies the basic role of the Mound-building mouse (Mus spicilegus Petenyi, 1882 as a carrier of Francisella tularensis. Spatial distribution of the Mound-building mouse strongly dependson a biotope, geographical region and weather conditions of a specific season. Mice nests in the storage mounds are located normally at a depth of 20–40 cm under the food storage chamber. Average number of the mice in storage mounds is 3.08 ± 1.54 in the south of investigated region and 3.88 ± 2.63 – in the NE of the region.

  20. 40 CFR Table 31 to Subpart Uuu of... - Continuous Monitoring Systems for HAP Emissions From Sulfur Recovery Units

    Science.gov (United States)

    2010-07-01

    ... stack; this monitor must include an oxygen monitor for correcting the data for excess oxygen; or ii... hourly average concentration of SO2 (dry basis) at zero percent excess air for each exhaust stack. This system must include an oxygen monitor for correcting the data for excess air. b. 300 ppmv of...

  1. Srs2 and Mus81-Mms4 Prevent Accumulation of Toxic Inter-Homolog Recombination Intermediates.

    Directory of Open Access Journals (Sweden)

    Kenji Keyamura

    2016-07-01

    Full Text Available Homologous recombination is an evolutionally conserved mechanism that promotes genome stability through the faithful repair of double-strand breaks and single-strand gaps in DNA, and the recovery of stalled or collapsed replication forks. Saccharomyces cerevisiae ATP-dependent DNA helicase Srs2 (a member of the highly conserved UvrD family of helicases has multiple roles in regulating homologous recombination. A mutation (srs2K41A resulting in a helicase-dead mutant of Srs2 was found to be lethal in diploid, but not in haploid, cells. In diploid cells, Srs2K41A caused the accumulation of inter-homolog joint molecule intermediates, increased the levels of spontaneous Rad52 foci, and induced gross chromosomal rearrangements. Srs2K41A lethality and accumulation of joint molecules were suppressed by inactivating Rad51 or deleting the Rad51-interaction domain of Srs2, whereas phosphorylation and sumoylation of Srs2 and its interaction with sumoylated proliferating cell nuclear antigen (PCNA were not required for lethality. The structure-specific complex of crossover junction endonucleases Mus81 and Mms4 was also required for viability of diploid, but not haploid, SRS2 deletion mutants (srs2Δ, and diploid srs2Δ mus81Δ mutants accumulated joint molecule intermediates. Our data suggest that Srs2 and Mus81-Mms4 have critical roles in preventing the formation of (or in resolving toxic inter-homolog joint molecules, which could otherwise interfere with chromosome segregation and lead to genetic instability.

  2. PEMANFAATAN Spirulina platensis SEBAGAI SUPLEMEN PROTEIN SEL TUNGGAL (PST MENCIT (Mus musculus

    Directory of Open Access Journals (Sweden)

    Haryo Kuntoro Adi

    2007-06-01

    Full Text Available The using of Spirulina platensis as Supplement of Single-Celled Protein (SCP to Mice. High protein in Spirulina platensis can be used as a source of Single-Celled Protein. By using mice (Mus musculus as a animal laboratory, the objective of this research is to know the influence of Biomass S. platensis to the increase of body weight of mice. The name of species is Mus musculus, strain is Swiss derivate. Utilized mice were male, 30-50 weighing gram, and 5-7 weeks of age. Treatment group was given by palette and given by biomass of S. Platensis, while control also fed palette but did not give biomass of S. platensis. Yielded biomass was used as food mixed with palette with composition of dry biomass S. platensis with palette was 0%, 10%, 20%, 30%, 40%, and 50%. Data analysis was conducted by using t-tes and analysis of variance. The results showed that by giving of dry biomass of S. platensis affected to the increasement of body weight from the first day until twelfth day of observation, and decrease on the thirteenth and fourteenth day. Pursuant to result of statistic, there is a significant difference (p < 0,05 between before giving and after giving of dry biomass S. platensis during 17 day. By giving dry biomass of S. platensis to mice (Mus musculus at first and second week, it was found the difference of average mice body weight among six concentrations of biomass but did not at the third week. It means that not all concentration of biomass have same effect to the increase of mice body weight as a Single-Celled Protein.

  3. Clinical implementation of an electron monitor unit dosimetry system based on task group 71 report and a commercial calculation program

    Directory of Open Access Journals (Sweden)

    Huijun Xu

    2016-01-01

    Full Text Available Many clinics still use monitor unit (MU calculations for electron treatment planning and/or quality assurance (QA. This work (1 investigates the clinical implementation of a dosimetry system including a modified American Association of Physicists in Medicine-task group-71 (TG-71-based electron MU calculation protocol (modified TG-71 electron [mTG-71E] and an independent commercial calculation program and (2 provides the practice recommendations for clinical usage. Following the recently published TG-71 guidance, an organized mTG-71E databook was developed to facilitate data access and subsequent MU computation according to our clinical need. A recently released commercial secondary calculation program - Mobius3D (version 1.5.1 Electron Quick Calc (EQC (Mobius Medical System, LP, Houston, TX, USA, with inherent pencil beam algorithm and independent beam data, was used to corroborate the calculation results. For various setups, the calculation consistency and accuracy of mTG-71E and EQC were validated by their cross-comparison and the ion chamber measurements in a solid water phantom. Our results show good agreement between mTG-71E and EQC calculations, with average 2% difference. Both mTG-71E and EQC calculations match with measurements within 3%. In general, these differences increase with decreased cutout size, increased extended source to surface distance, and lower energy. It is feasible to use TG71 and Mobius3D clinically as primary and secondary electron MU calculations or vice versa. We recommend a practice that only requires patient-specific measurements in rare cases when mTG-71E and EQC calculations differ by 5% or more.

  4. Monitor unit calculations for external photon and electron beams: Report of the AAPM Therapy Physics Committee Task Group No. 71

    Energy Technology Data Exchange (ETDEWEB)

    Gibbons, John P., E-mail: john.gibbons@marybird.com [Department of Physics, Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana 70809 (United States); Antolak, John A. [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905 (United States); Followill, David S. [Department of Radiation Physics, UT M.D. Anderson Cancer Center, Houston, Texas 77030 (United States); Huq, M. Saiful [Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232 (United States); Klein, Eric E. [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri 63110 (United States); Lam, Kwok L. [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109 (United States); Palta, Jatinder R. [Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298 (United States); Roback, Donald M. [Department of Radiation Oncology, Cancer Centers of North Carolina, Raleigh, North Carolina 27607 (United States); Reid, Mark [Department of Medical Physics, Fletcher-Allen Health Care, Burlington, Vermont 05401 (United States); Khan, Faiz M. [Department of Radiation Oncology, University of Minnesota, Minneapolis, Minnesota 55455 (United States)

    2014-03-15

    A protocol is presented for the calculation of monitor units (MU) for photon and electron beams, delivered with and without beam modifiers, for constant source-surface distance (SSD) and source-axis distance (SAD) setups. This protocol was written by Task Group 71 of the Therapy Physics Committee of the American Association of Physicists in Medicine (AAPM) and has been formally approved by the AAPM for clinical use. The protocol defines the nomenclature for the dosimetric quantities used in these calculations, along with instructions for their determination and measurement. Calculations are made using the dose per MU under normalization conditions, D{sub 0}{sup ′}, that is determined for each user's photon and electron beams. For electron beams, the depth of normalization is taken to be the depth of maximum dose along the central axis for the same field incident on a water phantom at the same SSD, where D{sub 0}{sup ′} = 1 cGy/MU. For photon beams, this task group recommends that a normalization depth of 10 cm be selected, where an energy-dependent D{sub 0}{sup ′} ≤ 1 cGy/MU is required. This recommendation differs from the more common approach of a normalization depth of d{sub m}, with D{sub 0}{sup ′} = 1 cGy/MU, although both systems are acceptable within the current protocol. For photon beams, the formalism includes the use of blocked fields, physical or dynamic wedges, and (static) multileaf collimation. No formalism is provided for intensity modulated radiation therapy calculations, although some general considerations and a review of current calculation techniques are included. For electron beams, the formalism provides for calculations at the standard and extended SSDs using either an effective SSD or an air-gap correction factor. Example tables and problems are included to illustrate the basic concepts within the presented formalism.

  5. Monitor unit calculations for external photon and electron beams: Report of the AAPM Therapy Physics Committee Task Group No. 71.

    Science.gov (United States)

    Gibbons, John P; Antolak, John A; Followill, David S; Huq, M Saiful; Klein, Eric E; Lam, Kwok L; Palta, Jatinder R; Roback, Donald M; Reid, Mark; Khan, Faiz M

    2014-03-01

    A protocol is presented for the calculation of monitor units (MU) for photon and electron beams, delivered with and without beam modifiers, for constant source-surface distance (SSD) and source-axis distance (SAD) setups. This protocol was written by Task Group 71 of the Therapy Physics Committee of the American Association of Physicists in Medicine (AAPM) and has been formally approved by the AAPM for clinical use. The protocol defines the nomenclature for the dosimetric quantities used in these calculations, along with instructions for their determination and measurement. Calculations are made using the dose per MU under normalization conditions, D'0, that is determined for each user's photon and electron beams. For electron beams, the depth of normalization is taken to be the depth of maximum dose along the central axis for the same field incident on a water phantom at the same SSD, where D'0 = 1 cGy/MU. For photon beams, this task group recommends that a normalization depth of 10 cm be selected, where an energy-dependent D'0 ≤ 1 cGy/MU is required. This recommendation differs from the more common approach of a normalization depth of dm, with D'0 = 1 cGy/MU, although both systems are acceptable within the current protocol. For photon beams, the formalism includes the use of blocked fields, physical or dynamic wedges, and (static) multileaf collimation. No formalism is provided for intensity modulated radiation therapy calculations, although some general considerations and a review of current calculation techniques are included. For electron beams, the formalism provides for calculations at the standard and extended SSDs using either an effective SSD or an air-gap correction factor. Example tables and problems are included to illustrate the basic concepts within the presented formalism.

  6. Identification of lymphocytic choriomeningitis mammarenavirus in house mouse (Mus musculus, Rodentia) in French Guiana.

    Science.gov (United States)

    Lavergne, Anne; de Thoisy, Benoît; Tirera, Sourakhata; Donato, Damien; Bouchier, Christiane; Catzeflis, François; Lacoste, Vincent

    2016-01-01

    Thirty-seven house mice (Mus musculus, Rodentia) caught in different localities in French Guiana were screened to investigate the presence of lymphocytic choriomeningitis mammarenavirus (LCMV). Two animals trapped in an urban area were found positive, hosting a new strain of LCMV, that we tentatively named LCMV "Comou". The complete sequence was determined using a metagenomic approach. Phylogenetic analyses revealed that this strain is related to genetic lineage I composed of strains inducing severe disease in humans. These results emphasize the need for active surveillance in humans as well as in house mouse populations, which is a rather common rodent in French Guianese cities and settlements.

  7. Are ribosomal DNA clusters rearrangement hotspots? A case study in the genus Mus (Rodentia, Muridae

    Directory of Open Access Journals (Sweden)

    Douzery Emmanuel JP

    2011-05-01

    Full Text Available Abstract Background Recent advances in comparative genomics have considerably improved our knowledge of the evolution of mammalian karyotype architecture. One of the breakthroughs was the preferential localization of evolutionary breakpoints in regions enriched in repetitive sequences (segmental duplications, telomeres and centromeres. In this context, we investigated the contribution of ribosomal genes to genome reshuffling since they are generally located in pericentromeric or subtelomeric regions, and form repeat clusters on different chromosomes. The target model was the genus Mus which exhibits a high rate of karyotypic change, a large fraction of which involves centromeres. Results The chromosomal distribution of rDNA clusters was determined by in situ hybridization of mouse probes in 19 species. Using a molecular-based reference tree, the phylogenetic distribution of clusters within the genus was reconstructed, and the temporal association between rDNA clusters, breakpoints and centromeres was tested by maximum likelihood analyses. Our results highlighted the following features of rDNA cluster dynamics in the genus Mus: i rDNA clusters showed extensive diversity in number between species and an almost exclusive pericentromeric location, ii a strong association between rDNA sites and centromeres was retrieved which may be related to their shared constraint of concerted evolution, iii 24% of the observed breakpoints mapped near an rDNA cluster, and iv a substantial rate of rDNA cluster change (insertion, deletion also occurred in the absence of chromosomal rearrangements. Conclusions This study on the dynamics of rDNA clusters within the genus Mus has revealed a strong evolutionary relationship between rDNA clusters and centromeres. Both of these genomic structures coincide with breakpoints in the genus Mus, suggesting that the accumulation of a large number of repeats in the centromeric region may contribute to the high level of chromosome

  8. Analysis of activity of motor units in the biceps brachii muscle after intercostal-musculocutaneous nerve transfer.

    Science.gov (United States)

    Sakuta, Naoki; Sasaki, Sei-Ichi; Ochiai, Naoyuki

    2005-04-01

    We examined respiratory activity of motor units (MUs) in the internal intercostal nerves (IICNs)-transferred biceps brachii muscle (IC-biceps) in cats. MUs of IC-biceps showed respiratory discharges in inspiratory and expiratory phases, and these were enhanced by CO2 inhalation. Narrowing the airway also enhanced inspiratory and expiratory MUs activity. A mechanical load to the thorax immediately enhanced inspiratory MUs activity and weakened expiratory MUs activity. We analyzed the cross-correlation of MUs activity in interchondral muscle and IC-biceps to characterize the respiratory spinal descending inputs to motoneurons. We confirmed the short-term synchronization from interchondral muscles indicating divergence of a single respiratory presynaptic axon to thoracic motoneurons, but could not find synchronization from IC-biceps. The motor axonal conduction velocity (axonal CV) of IC-biceps MUs was lower than that of interchondral muscles. There was no correlation between the respiratory recruitment order of IC-biceps MUs and their axonal CV. These results indicate that IC-biceps shows the respiratory activities and afferent inputs from intercostal muscle spindles in the neighboring segments remain influential on activity of IC-biceps. In addition, the short-term synchronization from IC-biceps could not be found, suggesting that the intercostal nerve transfer alters the respiratory spinal descending inputs to thoracic motoneurons.

  9. Chemical abundance analysis of symbiotic giants. RW Hya, SY Mus, BX Mon, and AE Ara

    CERN Document Server

    Galan, Cezary; Hinkle, Kenneth H; Schmidt, Miroslaw R; Gromadzki, Mariusz

    2014-01-01

    Symbiotic stars are the long period, binary systems of strongly interacting stars at the final stages of evolution which can be useful tool to understand the chemical evolution of the Galaxy and the formation of stellar populations. Knowledge of the chemical composition of the symbiotic giants is essential to advancing our understanding of these issues but unfortunately reliably determinations exist only in a few cases. We perform a program for detailed chemical composition analysis in over 30 symbiotic giants, based on the high resolution, near-IR spectra, obtained with Phoenix/Gemini South spectrometer. The methods of the standard LTE analysis is used to obtain photospheric abundances of CNO and elements around iron peak. Here we present results obtained for four objects: RW Hya, SY Mus, BX Mon, and AE Ara. Our analysis revealed a significantly sub-solar metallicity (Me/H ~ -0.75) for RW Hya, a slightly sub-solar metallicities (Me/H ~ 0.2-0.3) in BX Mon and AE Ara, and a near-solar metallicity in SY Mus. 12...

  10. Mate choice in Mus musculus is relative and dependent on the estrous state.

    Science.gov (United States)

    Zinck, Léa; Lima, Susana Q

    2013-01-01

    Mate choice is a critical behavioral decision process with profound impact on evolution. However, the mechanistic basis of mate choice is poorly understood. In this study we focused on assortative mate choice, which is known to contribute to the reproductive isolation of the two European subspecies of house mouse, Mus musculus musculus and Mus musculus domesticus. To understand the decision process, we developed both full mating and limited-contact paradigms and tested musculus females' preference for musculus versus domesticus males, mimicking the natural musculus/domesticus contact zone. As hypothesized, when allowed to mate we found that sexually receptive musculus females exhibited a robust preference to mate with musculus males. In contrast, when non-receptive, females did not exhibit a preference and rather alternated between males in response to male mount attempts. Moreover in a no-choice condition, females mated readily with males from both subspecies. Finally, when no physical contact was allowed, and therefore male's behavior could not influence female's behavior, female's preference for its own subspecies was maintained independently of the estrous state. Together, our results suggest that the assortative preference is relative and based on a comparison of the options available rather than on an absolute preference. The results of the limited-contact experiments highlight the interplay between female's internal state and the nature of the interaction with prospective mates in the full mating conditions. With these experiments we believe we established an assortative mate preference assay that is appropriate for the investigation of its underlying substrates.

  11. BEHAVIORAL AND MEMORY CHANGES IN Mus musculus COINFECTED BY Toxocara canis AND Toxoplasma gondii

    Directory of Open Access Journals (Sweden)

    Flávia Motta Corrêa

    2014-07-01

    Full Text Available Several researchers have stated that parasites can alter the behavior of their hosts, in order to increase the transmission rate, principally when prey-predator relationships are a reliable way of infection transmission. The aim of this study was to verify the occurrence of changes in anxiety and short-term memory patterns in experimentally infected Mus musculus by Toxocara canis and/or Toxoplasma gondii. Forty male Mus musculus (Balb/c eight-week-old were divided into four groups of 10 mice each. One group was infected with 300 eggs of Toxocara canis; a second group was submitted to infection with 10 cysts of Toxoplasma gondii; a third group was concomitantly infected with both parasites with the same inoculums and the last group was maintained without infection. The anxiety levels were evaluated using an elevated plus maze and an actometer; the short-term memory was determined by a two-way active avoidance equipment. The determination of anxiety levels were conducted 40 and 70 days after infection and the short-term memory was evaluated 140 days after infection. Mice chronically infected by Toxoplasma gondii showed impaired learning and short-term memory, but no significant differences were found in mice infected by Toxocara canis or concomitantly infected by Toxocara canis and Toxoplasma gondii when compared to non infected mice.

  12. EFEK ANTIFERTILITAS EKSTRAK AKAR SOM JAWA (Talinum paniculatum Gaertn. PADA MENCIT (Mus musculus L. JANTAN

    Directory of Open Access Journals (Sweden)

    Tetri Widiyani

    2012-10-01

    Full Text Available Talinum paniculatum Gaertn commonly is used as aphrodisiac herb. Phytosterol, saponin, flavonoid and tannin of the herb have a certain bioactivity and may affect to the body system. The objective of this research was to examine the antifertility effects of sam jawa (Talinum paniculatum Gaertn. root extract (SJRE on male mice (Mus musculus L.. Twenty male mice were divided into 4 groups randomly with 5 replications. SJRE was dissolved in aquadest and given orally everyday for 34 days. The treatment dosages were 0 (control, 100,200, and 300 mg/kg BW. At 35th day mice were sacrificed and sectioned to remove testes and epididymis spermatozoas. Testes were sectioned using paraffin method and stained using Haematoxyllin-Eosin. Spermatogenic cells in each seminiferous tubule were counted to investigated spermatogenesis activity of testes. Epididymis sperm suspension was used to investigate sperm quality i.e: morphology, velocity and motility. Quantitatives data were analized using ANOVA and continued DMRT on 5% significance level. The result showed SJRE had antifertility effects on male mice (Mus musculus L. could inhibit spermatogenesis (decrease the spermatogenic cells count and decrease the sperm quality (increase percentage of abnormal sperm, decrease sperm motility and also decrease sperm velocity.

  13. Mus cervicolor murine leukemia virus isolate M813 belongs to a unique receptor interference group.

    Science.gov (United States)

    Prassolov, V; Hein, S; Ziegler, M; Ivanov, D; Münk, C; Löhler, J; Stocking, C

    2001-05-01

    Murine leukemia virus (MuLV) M813 was originally isolated from the Southeast Asian rodent Mus cervicolor. As with the ecotropic MuLVs derived from Mus musculus, its host range is limited to rodent cells. Earlier studies have mapped its receptor to chromosome 2, but it has not been established whether M813 shares a common receptor with any other MuLVs. In this study, we have performed interference assays with M813 and viruses from four interference groups of MuLV. The infection efficiency of M813 was not compromised in cells expressing any one of the other MuLVs, demonstrating that M813 must use a distinct receptor for cell entry. The entire M813 env coding region was molecularly cloned. Sequence analysis revealed high similarity with other MuLVs but with a unique receptor-binding domain. Substitution of M813 env sequences in Moloney MuLV resulted in a replication-competent virus with a host range and interference profile similar to those of the biological clone M813. M813 thus defines a novel receptor interference group of type C MuLVs.

  14. Biochemical organization of single motor units in two multi-tendoned muscles of the cat distal forelimb.

    Science.gov (United States)

    Fritz, N; Schmidt, C; Yamaguchi, T

    1992-01-01

    In anesthetized cats single motor units (MUs) of the extensor carpi ulnaris (ECU) and extensor digitorum communis (EDC) muscles were selectively activated by stimulation of cervical ventral root filaments. The distribution of force developed by single MUs at the four distal tendons of the EDC muscle and at three portions of the distal tendon of the ECU muscle was analysed. In general, single MUs of both muscles distributed force over all tendons in a unimodal pattern, with the maximal force levels generated at one specific tendon which was termed the best-tendon. Distributions of force were quantitatively described by a parameter representing the mean direction of force output (output-index) and a further one representing the dispersion of force over the distal tendons (divergence). Generally, these parameters and the best-tendon remained stable when a MU was stimulated at different frequencies, but varied from MU to MU. Despite the general stability of the force distribution, slight systematic changes were regularly found in EDC MUs, when they developed a higher amount of force due to a higher frequency of stimulation: the relative amount of force at the best-tendon increased; e.g. the MUs got more selective for the best-tendon. These changes were partly due to overcoming mechanical cross-coupling between neighbouring compartments of the EDC muscle. Such changes of force distribution were only found in a part of the ECU MUs; other ECU MUs did not change their force distribution at all or became less selective for the best-tendon. The phenomenon that MUs of multi-tendoned muscles distribute their force output to the distal tendons in specific patterns is probably due to mechanical partitioning of the parent muscles: the localization of spatial territories of MUs within different anatomical muscle compartments should correspond to the best-tendon. Complex mechanisms allowing passive transmission of force from limited territories along the transverse axis of both

  15. POST-CLOSURE INSPECTION AND MONITORING REPORT FOR CORRECTIVE ACTION UNIT 112: AREA 23 HAZARDOUS WASTE TRENCHES, NEVADA TEST SITE, NEVADA; FOR THE PERIOD OCTOBER 2003 - SEPTEMBER 2004

    Energy Technology Data Exchange (ETDEWEB)

    BECHTEL NEVADA

    2004-12-01

    Corrective Action Unit (CAU) 112, Area 23 Hazardous Waste Trenches, Nevada Test Site (NTS), Nevada, is a Resource Conservation and Recovery Act (RCRA) unit located in Area 23 of the NTS. This annual Post-Closure Inspection and Monitoring Report provides the results of inspections and monitoring for CAU 112. This report includes a summary and analysis of the site inspections, repair and maintenance, meteorological information, and neutron soil moisture monitoring data obtained at CAU 112 for the current monitoring period, October 2003 through September 2004. Inspections of the CAU 112 RCRA unit were performed quarterly to identify any significant physical changes to the site that could impact the proper operation of the waste unit. The overall condition of the covers and facility was good, and no significant findings were observed. The annual subsidence survey of the elevation markers was conducted on August 23, 2004, and the results indicated that no cover subsidence4 has occurred at any of the markers. The elevations of the markers have been consistent for the past 11 years. The total precipitation for the current reporting period, october 2003 to September 2004, was 14.0 centimeters (cm) (5.5 inches [in]) (National Oceanographic and Atmospheric Administration, Air Resources Laboratory, Special Operations and Research Division, 2004). This is slightly below the average rainfall of 14.7 cm (5.79 in) over the same period from 1972 to 2004. Post-closure monitoring verifies that the CAU 112 trench covers are performing properly and that no water is infiltrating into or out of the waste trenches. Sail moisture measurements are obtained in the soil directly beneath the trenches and compared to baseline conditions for the first year of post-closure monitoring, which began in october 1993. neutron logging was performed twice during this monitoring period along 30 neutron access tubes to obtain soil moisture data and detect any changes that may indicate moisture movement

  16. SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr).

    Science.gov (United States)

    Zhou, Xiaohong; DeLucia, Maria; Ahn, Jinwoo

    2016-08-12

    Evolutionarily conserved structure-selective endonuclease MUS81 forms a complex with EME1 and further associates with another endonuclease SLX4-SLX1 to form a four-subunit complex of MUS81-EME1-SLX4-SLX1, coordinating distinctive biochemical activities of both endonucleases in DNA repair. Viral protein R (Vpr), a highly conserved accessory protein in primate lentiviruses, was previously reported to bind SLX4 to mediate down-regulation of MUS81. However, the detailed mechanism underlying MUS81 down-regulation is unclear. Here, we report that HIV-1 Vpr down-regulates both MUS81 and its cofactor EME1 by hijacking the host CRL4-DCAF1 E3 ubiquitin ligase. Multiple Vpr variants, from HIV-1 and SIV, down-regulate both MUS81 and EME1. Furthermore, a C-terminally truncated Vpr mutant and point mutants R80A and Q65R, all of which lack G2 arrest activity, are able to down-regulate MUS81-EME1, suggesting that Vpr-induced G2 arrest is not correlated with MUS81-EME1 down-regulation. We also show that neither the interaction of MUS81-EME1 with Vpr nor their down-regulation is dependent on SLX4-SLX1. Together, these data provide new insight on a conserved function of Vpr in a host endonuclease down-regulation.

  17. Monitoring and Assessment Science to Support Decision-Making by the United Nations Convention to Combat Desertification (UNCCD)

    Science.gov (United States)

    Winslow, M.; Akhtar-Schuster, M.; Cherlet, M.; Martius, C.; Sommer, S.; Thomas, R.; Vogt, J.

    2009-12-01

    The United Nations Convention to Combat Desertification (UNCCD) is a global treaty that emerged from the Rio Earth Summit and formally took force in 1996. It has now been ratified by 193 countries (known as Parties to the Convention). Yet the UNCCD has gained only modest support from donors, largely due to questions about the science base underlying its target issue (desertification) resulting in ambiguous definitions and quantification of the problem. The UNCCD recognizes the need to reform itself and commissioned a scientific conference in Buenos Aires, Argentina in September 2009 to discuss ways to improve the scientific underpinning of monitoring and assessment (M&A) of desertification, land degradation and drought (DLDD). Previous attempts by the UNCCD on M&A focused largely on a search for a common, simple, universal set of indicators that could be reported by country Parties to the Convention Secretariat, which would collate them into a global report. However experience found that no single set of indicators is satisfactory to all countries, because DLDD depends strongly on the local environmental and human/social context. Three preparatory Working Groups analyzed the issue of DLDD M&A and recommended the following. Parties should recognize that M&A methods must integrate human-environment parameters to capture the complexity of DLDD phenomena as defined in the Convention’s text. Traditional tendencies had been to isolate biophysical from social and economic parameters, leading to unrealistic conclusions. Parties should take advantage of a much wider range of analytical techniques than just the coarse-scale indicators that had been their main focus to date. Powerful but underutilized techniques include integrated assessment models, remote sensing, geographic information systems and mapping, participatory stakeholder assessment, hierarchical aggregation of related data, knowledge management and many others. Multiple methods could provide validation checks

  18. Continuous glucose monitoring system in the operating room and intensive care unit: any difference according to measurement sites?

    Science.gov (United States)

    Song, In-Kyung; Lee, Ji-Hyun; Kang, Joo-Eun; Park, Yang-Hyo; Kim, Hee-Soo; Kim, Jin-Tae

    2017-02-01

    Given the benefit of glucose control in the perioperative period, we evaluated the accuracy and performance of the continuous glucose monitoring system (CGMS) depending on different measurement sites in the operating room (OR) and in the intensive care unit (ICU). Patients over 18 years of age scheduled for elective surgery and ICU admission were enrolled prospectively. Two CGMS sensors were inserted into the subcutaneous tissue of the proximal lateral thigh and the lateral abdomen. The rate of successful measurements from thigh and abdomen in the OR and in the ICU were calculated separately. Each CGMS values were compared with the time-matched arterial blood glucose measurements. CGMS values from both measurement sites were also compared. A total of 22 patients undergoing cardiac surgeries were studied. The rate of successful measurements was higher in the ICU (73.2 %) than in the OR (66.0 %) (P = 0.01); however, that from thigh (72.9 %) and from abdomen (58.7 %) showed statistically significant difference only in the OR (P = 0.04). The Pearson correlation coefficient of thigh and abdomen versus arterial values was 0.67 and 0.60, respectively (P < 0.001). In Clarke error grid analysis, 94.6 % (89.3 % in the OR and 96.1 % in the ICU) of values from thigh fell into clinically acceptable zones compared to 93.7 % (89.0 % in the OR and 95.4 % in the ICU) from abdomen. There were no statistically significant differences in the accuracy according to measurement sites. The CGMS showed high measurement failure rate, especially in the OR. In the OR, the rate of successful measurement was higher from thigh than from abdomen. The CGMS showed low accuracy compared to arterial reference values. Nevertheless, there was no difference in the accuracy of the CGMS between two measurement sites. Perioperative performance of the CGMS still needs to be improved considering relatively low successful measurement rates.

  19. 40 CFR Table 7 to Subpart Ggg of... - Wastewater-Inspection and Monitoring Requirements for Waste Management Units

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Wastewater-Inspection and Monitoring..., Subpt. GGG, Table 7 Table 7 to Subpart GGG of Part 63—Wastewater—Inspection and Monitoring Requirements...(b)(7)63.1256(b)(8) Inspect wastewater tank for control equipment failures and improper...

  20. Spectroscopic studies of Cepheids (S Cru, AP Pup, AX Cir, S TrA, T Cru, R Mus, S Mus, U Car) and semiregular bright supergiants (V382 Car, HD 75276, R Pup) in the southern hemisphere

    Science.gov (United States)

    Usenko, I. A.; Kniazev, A. Yu.; Berdnikov, L. N.; Kravtsov, V. V.

    2011-07-01

    We present the second part of the results of our work to investigate the atmospheric parameters and chemical composition of southern-hemisphere Cepheids obtained by analyzing 24 spectra for eight bright Cepheids and three semiregular bright supergiants taken with the 1.9-m telescope of the South African Astronomical Observatory. The chemical composition and atmospheric parameters have been determined for S Cru, AP Pup, AX Cir, S TrA, T Cru, R Mus, S Mus, U Car, V382 Car, HD 75276, and R Pup.

  1. Baseline and Postremediation Monitoring Program Plan for the Lower East Fork Poplar Creek operable unit, Oak Ridge, Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    This report was prepared in accordance with CERCLA requirements to present the plan for baseline and postremediation monitoring as part of the selected remedy. It provides the Environmental Restoration Program with information about the requirements to monitor for soil and terrestrial biota in the Lower East Fork Poplar Creek (LEFPC) floodplain; sediment, surface water, and aquatic biota in LEFPC; wetland restoration in the LEFPC floodplain; and human use of shallow groundwater wells in the LEFPC floodplain for drinking water. This document describes the monitoring program that will ensure that actions taken under Phases I and II of the LEFPC remedial action are protective of human health and the environment.

  2. Parâmetros morfofisiológicos testiculares de camundongos (Mus musculus suplementados com geleia real Morphophysiological parameters of mice (Mus musculus testicles supplemented with royal jelly

    Directory of Open Access Journals (Sweden)

    A.C.T. Morais

    2009-02-01

    Full Text Available Avaliaram-se os efeitos da geleia real sobre os parâmetros morfofisiológicos testiculares de camundongos (Mus musculus. Utilizaram-se 57 machos Swiss, com quatro meses de idade, distribuídos aleatoriamente em seis tratamentos: T1: solução fisiológica, via intraperitoneal; T2: 0,1mg de geleia real, via intraperitoneal; T3: 0,2mg de geleia real, via intraperitoneal; T4: água destilada, via oral; T5: 0,1mg de geleia real, via oral; e T6: 0,2mg de geleia real, via oral. Após 45 dias de suplementação com geleia real, os animais sacrificados e pesados tiveram seus testículos coletados, incluídos em parafina e corados com hematoxilina/eosina. Não houve diferença entre os tratamentos quanto aos: pesos corporal e testicular, índice gonadossomático, diâmetro tubular, altura do epitélio, comprimento total dos túbulos seminíferos, comprimento tubular por grama de testículo, índices tubulossomático e leydigossomático e valores de proporção volumétrica referentes à túnica própria, epitélio seminífero, vaso sanguíneo e vaso linfático. Foi encontrada diferença entre T1 e T3 em relação aos túbulos seminíferos e ao espaço intertubular.The effects of royal jelly on the morphophysiological parameters of mice (Mus musculus testicles were studied. Fifty-eight male Swiss mice were evaluated. They were four-month old and were randomly distributed in six treatments: T1: physiological solution, intraperitonial route; T2: 0.1mg of royal jelly, intraperitonial route; T3: 0.2mg of royal jelly, intraperitonial route; T4: distilled water, orally; T5: 0.1mg of royal jelly, orally; and T6: 0.2mg of royal jelly, orally. After 45 days of supplementation with royal jelly, the animals were weighted, slaughtered, and the testicles collected, included in paraffin, and stained with haematoxylin-eosin. No differences among treatments were observed for: body and testicular weights, gonadossomatic index, tubular diameter, epithelial height, total

  3. Antimutagenic effects of aqueous fraction of Myristica fragrans (Houtt.) leaves on Salmonella typhimurium and Mus musculus.

    Science.gov (United States)

    Akinboro, Akeem; Bin Mohamed, Kamaruzaman; Asmawi, Mohd Zaini; Yekeen, Taofeek A

    2014-01-01

    Natural plant extracts offer a promising hope in the prevention/treatment of cancer arising from genetic mutations. This study evaluated in vitro and in vivo mutagenic and antimutagenic effects of aqueous fraction of Myristica fragrans (AFMF) leaves on TA100 strain of Salmonella typhimurium and Mus musculus (Male Swiss albino mice), respectively. The antioxidant activity of AFMF against 2,2-diphenyl-1-picrylhydrazyl (DPPH), total phenolic and flavonoid contents were determined, followed by its phytochemical elucidation using the Ultra Performance Liquid Chromatography technique (UPLC). The mutagenicity of AFMF at 4, 20, 50, 100, 200, 500, and 1000 µg/well was Rutin was elucidated by the UPLC technique, and thereby suspected to be the phytochemical responsible for the observed antimutagenic activity. Thus far, AFMF seems to contain a promising chemotherapeutic agent for the prevention of genetic damage that is crucial for cancer development.

  4. Philippe Ortoli. Le Musée imaginaire de Quentin Tarantino

    OpenAIRE

    Roche, David

    2014-01-01

    Première étude approfondie consacrée au cinéaste américain en français, Le Musée imaginaire de Quentin Tarantino est, à ce titre, déjà un véritable événement. Le livre comporte un prologue, une introduction, quatre chapitres de taille conséquente, une conclusion, un index des films cités, une filmographie et une bibliographie. Le prologue et l’introduction présentent Tarantino comme le premier véritable « auteur-star » depuis Alfred Hitchcock, cherchant, comme ce dernier, à être visible, mais...

  5. Sexual selection and the rodent baculum: an intraspecific study in the house mouse (Mus musculus domesticus).

    Science.gov (United States)

    Ramm, Steven A; Khoo, Lin; Stockley, Paula

    2010-01-01

    The rapid divergence of genitalia is a pervasive trend in animal evolution, thought to be due to the action of sexual selection. To test predictions from the sexual selection hypothesis, we here report data on the allometry, variation, plasticity and condition dependence of baculum morphology in the house mouse (Mus musculus domesticus). We find that that baculum size: (a) exhibits no consistent pattern of allometric scaling (baculum size being in most cases unrelated to body size), (b) exhibits low to moderate levels of phenotypic variation, (c) does not exhibit phenotypic plasticity in response to differences in perceived levels of sexual competition and (d) exhibits limited evidence of condition dependence. These patterns provide only limited evidence in support of the sexual selection hypothesis, and no consistent support for any particular sexual selection mechanism; however, more direct measures of how genital morphology influences male fertilization success are required.

  6. Reduced meiotic fitness in hybrids with heterozygosity for heterochromatin in the speciating Mus terricolor complex

    Indian Academy of Sciences (India)

    Tikaram Sharma; Amit Bardhan; Min Bahadur

    2003-03-01

    Mus terricolor I, II and III are the three chromosomal species which differ in stable autosomal short-arm heterochromatin variations established in homozygous condition. Analysis of meiosis in the laboratorygenerated F1 male hybrids from crosses (both ways) between M. terricolor I and II and between M. terricolor I and III shows high frequencies of pairing abnormalities at pachytene. The backcross (N3 generation) male hybrids between M. terricolor I and II have meiotic abnormalities as in the F1 male hybrids, though to a lesser extent. They show difference in pairing abnormalities in the different karyotypic forms; the backcross hybrids heterozygous for the heterochromatic short arms have more anomalies compared to the homokaryotypic hybrids. This suggests a negative influence of the heterochromatin heterozygosity in meiotic pairing. The results indicate a role for heterochromatin variations in the development of a reproductive barrier in the speciating M. terricolor complex.

  7. Amikacin Dosing and Monitoring in Spinal Cord Injury Patients: Variation in Clinical Practice Between Spinal Injury Units and Differences in Experts' Recommendations

    Directory of Open Access Journals (Sweden)

    Subramanian Vaidyanathan

    2006-01-01

    Full Text Available The objective of this article was to determine the current practice on amikacin dosing and monitoring in spinal cord injury patients from spinal cord physicians and experts. Physicians from spinal units and clinical pharmacologists were asked to provide protocol for dosing and monitoring of amikacin therapy in spinal cord injury patients. In a spinal unit in Poland, amikacin is administered usually 0.5 g twice daily. A once-daily regimen of amikacin is never used and amikacin concentrations are not determined. In Belgium, Southport (U.K., Spain, and the VA McGuire Medical Center (Richmond, Virginia, amikacin is given once daily. Whereas peak and trough concentrations are determined in Belgium, only trough concentration is measured in Southport. In both these spinal units, modification of the dose is not routinely done with a nomogram. In Spain and the VA McGuire Medical Center, monitoring of serum amikacin concentration is not done unless a patient has renal impairment. In contrast, the dose/interval of amikacin is adjusted according to pharmacokinetic parameters at the Edward Hines VA Hospital (Hines, Illinois, where amikacin is administered q24h or q48h, depending on creatinine clearance. Spinal cord physicians from Denmark, Germany, and the Kessler Institute for Rehabilitation (West Orange, New Jersey state that they do not use amikacin in spinal injury patients. An expert from Canada does not recommend determining serum concentrations of amikacin, but emphasizes the value of monitoring ototoxicity and nephrotoxicity. Experts from New Zealand recommend amikacin in conventional twice- or thrice-daily dosing because of the theoretical increased risk of neuromuscular blockade and apnea with larger daily doses in spinal cord injury patients. On the contrary, experts from Greece, Israel, and the U.S. recommend once-daily dosing and determining amikacin pharmacokinetic parameters for each patient. As there is considerable variation in clinical

  8. Preliminary Characterization of Mus musculus–Derived Pathogenic Strains of Leptospira borgpetersenii Serogroup Ballum in a Hamster Model

    Science.gov (United States)

    da Silva, Éverton F.; Félix, Samuel R.; Cerqueira, Gustavo M.; Fagundes, Michel Q.; Neto, Amilton C. P. S.; Grassmann, André A.; Amaral, Marta G.; Gallina, Tiago; Dellagostin, Odir A.

    2010-01-01

    Human and animal leptospirosis caused by Leptospira spp. belonging to serogroup Ballum has increased worldwide in the past decade. We report the isolation and serologic and molecular characterization of four L. borgpetersenii serogroup Ballum isolates obtained from Mus musculus, and preliminary virulence studies. These isolates are useful for diagnosis of leptospirosis and for epidemiologic studies of its virulence and pathogenic mechanisms. PMID:20682877

  9. Transformative Poetry : A Case Study of W.H. Auden's Musée des Beaux Arts And General Conclusions

    NARCIS (Netherlands)

    Sarot, Marcel

    2016-01-01

    This article situates Auden’s poem Musée des Beaux Arts in the process of his conversion to Christianity. The author argues for the layered intertextuality of the poem, in which allusions to Bruegel’s Landscape with the Fall of Icarus, The Census at Jerusalem, and The Massacre of the Innocents can b

  10. Transformative Poetry : A Case Study of W.H. Auden's Musée des Beaux Arts And General Conclusions

    NARCIS (Netherlands)

    Sarot, Marcel

    2016-01-01

    This article situates Auden’s poem Musée des Beaux Arts in the process of his conversion to Christianity. The author argues for the layered intertextuality of the poem, in which allusions to Bruegel’s Landscape with the Fall of Icarus, The Census at Jerusalem, and The Massacre of the Innocents can b

  11. POST CLOSURE INSPECTION AND MONITORING REPORT FOR CORRECTIVE ACTION UNIT 417: CENTRAL NEVADA TEST AREA - SURFACE, HOT CREEK VALLEY, NEVADA, FOR CALENDAR YEAR 2004

    Energy Technology Data Exchange (ETDEWEB)

    BECHTEL NEVADA; NNSA NEVADA SITE OFFICE

    2005-04-01

    This post-closure inspection and monitoring report has been prepared according to the stipulations laid out in the Closure Report (CR) for Corrective Action Unit (CAU) 417, Central Nevada Test Area (CNTA)--Surface (U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office [NNSA/NV], 2001), and the Federal Facility Agreement and Consent Order (FFACO, 1996). This report provides an analysis and summary of site inspections, subsidence surveys, meteorological information, and soil moisture monitoring data for CAU 417, which is located in Hot Creek Valley, Nye County, Nevada. This report covers Calendar Year 2004. Inspections at CAU 417 are conducted quarterly to document the physical condition of the UC-1, UC-3, and UC-4 soil covers, monuments, signs, fencing, and use restricted areas. The physical condition of fencing, monuments, and signs is noted, and any unusual conditions that could impact the integrity of the covers are reported. The objective of the soil moisture monitoring program is to monitor the stability of soil moisture conditions within the upper 1.2 meters (m) (4 feet [ft]) of the UC-1 Central Mud Pit (CMP) cover and detect changes that may be indicative of moisture movement exceeding the cover design performance expectations.

  12. 40 CFR Table 5 to Subpart Ppp of... - Process Vents From Batch Unit Operations-Monitoring, Recordkeeping, and Reporting Requirements

    Science.gov (United States)

    2010-07-01

    ... Hazardous Air Pollutant Emissions for Polyether Polyols Production Pt. 63, Subpt. PPP, Table 5 Table 5 to... all instances when monitoring data are not collected—PR. d,e If a base absorbent is used, report all pH values that are below the minimum operating values. If an acid absorbent is used, report all...

  13. 40 CFR Table 11 to Subpart G of... - Wastewater-Inspection and Monitoring Requirements for Waste Management Units

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Wastewater-Inspection and Monitoring... Operations, and Wastewater Pt. 63, Subpt. G, Table 11 Table 11 to Subpart G of Part 63—Wastewater—Inspection... wastewater tank for control equipment failures and improper work practices Initially Semi-annually...

  14. Comparison between In-house developed and Diamond commercial software for patient specific independent monitor unit calculation and verification with heterogeneity corrections.

    Science.gov (United States)

    Kuppusamy, Vijayalakshmi; Nagarajan, Vivekanandan; Jeevanandam, Prakash; Murugan, Lavanya

    2016-02-01

    The study was aimed to compare two different monitor unit (MU) or dose verification software in volumetric modulated arc therapy (VMAT) using modified Clarkson's integration technique for 6 MV photons beams. In-house Excel Spreadsheet based monitor unit verification calculation (MUVC) program and PTW's DIAMOND secondary check software (SCS), version-6 were used as a secondary check to verify the monitor unit (MU) or dose calculated by treatment planning system (TPS). In this study 180 patients were grouped into 61 head and neck, 39 thorax and 80 pelvic sites. Verification plans are created using PTW OCTAVIUS-4D phantom and also measured using 729 detector chamber and array with isocentre as the suitable point of measurement for each field. In the analysis of 154 clinically approved VMAT plans with isocentre at a region above -350 HU, using heterogeneity corrections, In-house Spreadsheet based MUVC program and Diamond SCS showed good agreement TPS. The overall percentage average deviations for all sites were (-0.93% + 1.59%) and (1.37% + 2.72%) for In-house Excel Spreadsheet based MUVC program and Diamond SCS respectively. For 26 clinically approved VMAT plans with isocentre at a region below -350 HU showed higher variations for both In-house Spreadsheet based MUVC program and Diamond SCS. It can be concluded that for patient specific quality assurance (QA), the In-house Excel Spreadsheet based MUVC program and Diamond SCS can be used as a simple and fast accompanying to measurement based verification for plans with isocentre at a region above -350 HU.

  15. Monitoring of physical health parameters for inpatients on a child and adolescent mental health unit receiving regular antipsychotic therapy.

    Science.gov (United States)

    Pasha, Nida; Saeed, Shoaib; Drewek, Katherine

    2015-01-01

    Physical health monitoring of patients receiving antipsychotics is vital. Overall it is estimated that individuals suffering with conditions like schizophrenia have a 20% shorter life expectancy than the average population, moreover antipsychotic use has been linked to a number of conditions including diabetes, obesity, and cardiovascular disease.[1-4] The severity of possible adverse effects to antipsychotics in adults has raised awareness of the importance of monitoring physical health in this population. However, there is little literature available as to the adverse effects of these medications in the child and adolescent community, which make physical health monitoring in this predominantly antipsychotic naïve population even more important. An expert group meeting in the UK has laid down recommendations in regards to screening and management of adult patients receiving antipsychotics, however no specific guidelines have been put in place for the child and adolescent age group.[5] The aim of this audit was to establish whether in-patients receiving antipsychotics had the following investigations pre-treatment and 12 weeks after treatment initiation: body mass index, hip-waist circumference, blood pressure, ECG, urea and electrolytes, full blood count, lipid profile, random glucose level, liver function test, and prolactin. This is in addition to a pre-treatment VTE risk assessment. These standards were derived from local trust guidelines, NICE guidelines on schizophrenia [6] and The Maudsley Prescribing Guidelines.[7] We retrospectively reviewed 39 electronic case notes in total, of which 24 cases were post intervention. Intervention included the use of a prompting tool. This tool was filed in the physical health files of all patients receiving antipsychotics which was intended as a reminder to doctors regarding their patient's need for physical health monitoring. Professionals involved in the monitoring of such parameters were educated in the importance and

  16. Corrections to traditional methods of verifying tangential-breast 3D monitor-unit calculations: use of an equivalent triangle to estimate effective fields.

    Science.gov (United States)

    Prado, Karl L; Kirsner, Steven M; Erice, Rolly C

    2003-01-01

    This paper describes an innovative method for correctly estimating the effective field size of tangential-breast fields. The method uses an "equivalent triangle" to verify intact breast tangential field monitor-unit settings calculated by a 3D planning system to within 2%. The effects on verification calculations of loss of full scatter due to beam oblique incidence, proximity to field boundaries, and reduced scattering volumes are handled properly. The methodology is validated by comparing calculations performed by the 3D planning system with the respective verification estimates. The accuracy of this technique is established for dose calculations both with and without heterogeneity corrections.

  17. Environmental Monitoring, Water Quality - BACTERIA_MONITORING_EPA_IN: Bacteria Monitoring Stations and Data Summaries in Indiana, Derived from EPA BASINS 3 (United States Environmental Protection Agency, 1:45,000, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — BACTERIA_MONITORING_EPA_IN is a point shapefile developed by the USEPA BASINS 3.0 program and edited by Bernardin, Lochmueller and Associates. Joinable tables must...

  18. Clinical and behavioral characteristics of adults receiving medical care for HIV infection --- Medical Monitoring Project, United States, 2007.

    Science.gov (United States)

    Blair, Janet M; McNaghten, A D; Frazier, Emma L; Skarbinski, Jacek; Huang, Ping; Heffelfinger, James D

    2011-09-02

    As of December 31, 2008, an estimated 663,084 persons were living with a diagnosis of human immunodeficiency virus (HIV) infection in the 40 U.S. states that have had confidential name-based HIV infection reporting since at least January 2006. Although HIV surveillance programs in the United States collect information about persons who have received a diagnosis of HIV infection and acquired immunodeficiency syndrome (AIDS), supplemental surveillance projects are needed to collect information about care-seeking behaviors, health-care use, and other behaviors among persons living with HIV. Data on the clinical and behavioral characteristics of persons receiving medical care for HIV infection are critical to reduce HIV-related morbidity and mortality and for program planning to allocate services and resources, guide prevention planning, assess unmet medical and ancillary service needs, and help develop intervention programs and health policies at the local, state, and national levels. Data were collected during June 2007-September 2008 for patients who received medical care in 2007 (sampled from January 1-April 30). The Medical Monitoring Project (MMP) is an ongoing, multisite supplemental surveillance project that assesses behaviors, clinical characteristics, and quality of care of HIV-infected persons who are receiving medical care. Participants must be aged ≥ 18 years and have received medical care at sampled facilities that provide HIV medical care within participating MMP project areas. Self-reported behavioral and selected clinical data are collected using an in-person interview. A total of 26 project areas in 19 states and Puerto Rico were funded to collect data during the 2007 MMP data collection cycle. The results from the 2007 MMP cycle indicated that among 3,643 participants, a total of 3,040 (84%) had some form of health insurance or coverage during the 12 months before the interview; of these, 45% reported having Medicaid, 37% reported having private

  19. Long-Term Outdoor Reliability Assessment of a Wireless Unit for Air-Quality Monitoring Based on Nanostructured Films Integrated on Micromachined Platforms

    Directory of Open Access Journals (Sweden)

    Massimiliano Decarli

    2012-06-01

    Full Text Available We have fabricated and tested in long-term field operating conditions a wireless unit for outdoor air quality monitoring. The unit is equipped with two multiparametric sensors, one miniaturized thermo-hygrometer, front-end analogical and digital electronics, and an IEEE 802.15.4 based module for wireless data transmission. Micromachined platforms were functionalized with nanoporous metal-oxides to obtain multiparametric sensors, hosting gas-sensitive, anemometric and temperature transducers. Nanoporous metal-oxide layer was directly deposited on gas sensing regions of micromachined platform batches by hard-mask patterned supersonic cluster beam deposition. An outdoor, roadside experiment was arranged in downtown Milan (Italy, where one wireless sensing unit was continuously operated side by side with standard gas chromatographic instrumentation for air quality measurements. By means of a router PC, data from sensing unit and other instrumentation were collected, merged, and sent to a remote data storage server, through an UMTS device. The whole-system robustness as well as sensor dataset characteristics were continuously characterized over a run-time period of 18 months.

  20. Long-term outdoor reliability assessment of a wireless unit for air-quality monitoring based on nanostructured films integrated on micromachined platforms.

    Science.gov (United States)

    Leccardi, Matteo; Decarli, Massimiliano; Lorenzelli, Leandro; Milani, Paolo; Mettala, Petteri; Orava, Risto; Barborini, Emanuele

    2012-01-01

    We have fabricated and tested in long-term field operating conditions a wireless unit for outdoor air quality monitoring. The unit is equipped with two multiparametric sensors, one miniaturized thermo-hygrometer, front-end analogical and digital electronics, and an IEEE 802.15.4 based module for wireless data transmission. Micromachined platforms were functionalized with nanoporous metal-oxides to obtain multiparametric sensors, hosting gas-sensitive, anemometric and temperature transducers. Nanoporous metal-oxide layer was directly deposited on gas sensing regions of micromachined platform batches by hard-mask patterned supersonic cluster beam deposition. An outdoor, roadside experiment was arranged in downtown Milan (Italy), where one wireless sensing unit was continuously operated side by side with standard gas chromatographic instrumentation for air quality measurements. By means of a router PC, data from sensing unit and other instrumentation were collected, merged, and sent to a remote data storage server, through an UMTS device. The whole-system robustness as well as sensor dataset characteristics were continuously characterized over a run-time period of 18 months.

  1. Hematologic, Hepatic, Renal and Lipid Laboratory Monitoring Following Initiation of Combination Antiretroviral Therapy in the United States, 2000–2010

    Science.gov (United States)

    Yanik, Elizabeth L.; Napravnik, Sonia; Ryscavage, Patrick; Eron, Joseph J.; Koletar, Susan L.; Moore, Richard D.; Zinski, Anne; Cole, Stephen R.; Hunt, Peter; Crane, Heidi M.; Kahn, James; Mathews, W. Christopher; Mayer, Kenneth; Taiwo, Babafemi

    2013-01-01

    We assessed laboratory monitoring following combination antiretroviral therapy (cART) initiation among 3,678 patients in a large US multi-site clinical cohort, censoring participants at last clinic visit, cART change, or three years. Median days (interquartile range) to first hematologic, hepatic, renal and lipid tests were 30 (18–53), 31 (19–56), 33 (20–59) and 350 (96–1106), respectively. At one year, approximately 80% received more than two hematologic, hepatic, and renal tests consistent with guidelines. However, only 40% received one or more lipid tests. Monitoring was more frequent in specific subgroups, likely reflecting better clinic attendance or clinician perception of higher susceptibility to toxicities. PMID:23446495

  2. Post-Closure Monitoring Report for Corrective Action Unit 339: Area 12 Fleet Operations Steam Cleaning Effluent Nevada Test Site, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    K. B. Campbell

    2002-09-01

    The Area 12 Fleet Operations Steam Cleaning Effluent site is located in the southeastern portion of the Area 12 Camp at the Nevada Test Site. This site is identified in the Federal Facility Agreement and Consent Order (1996) as Corrective Action Site (CAS) 12-19-01 and is the only CAS assigned to Corrective Action Unit (CAU) 339. Post-closure sampling and inspection of the site were completed on March 27, 2002. Post-closure monitoring activities were scheduled biennially (every two years) in the Post-Closure Monitoring Plan provided in the Closure Report for CAU 339: Area 12 Fleet Operations Steam Cleaning Effluent, Nevada Test Site (U.S. Department of Energy, Nevada Operations Office [DOEN], 1997). A baseline for the site was established by sampling in 1997. Based on the recommendations from the 1999 post-closure monitoring report (DOE/NV, 1999), samples were collected in 2000, earlier than originally proposed, because the 1999 sample results did not provide the expected decrease in total petroleum hydrocarbon (TPH) concentrations at the site. Sampling results from 2000 (DOE/NV, 2000) and 2001 (DOE/NV, 2001) revealed favorable conditions for natural degradation at the CAU 339 site, but because of differing sample methods and heterogeneity of the soil, data results from 2000 and later were not directly correlated with previous results. Post-closure monitoring activities for 2002 consisted of the following: (1) Soil sample collection from three undisturbed plots (Plots A, B, and C, Figure 2). (2) Sample analysis for TPH as oil and bio-characterization parameters (Comparative Enumeration Assay [CEA] and Standard Nutrient Panel [SNP]). (3) Site inspection to evaluate the condition of the fencing and signs. (4) Preparation and submittal of the Post-Closure Monitoring Report.

  3. Reflexões sobre a arte "primitiva": o caso do Musée Branly

    Directory of Open Access Journals (Sweden)

    Ilana Goldstein

    2008-06-01

    Full Text Available Na época das descobertas ultramarinas, os europeus acumulavam fragmentos das novas realidades que encontravam em suas viagens, nos chamados gabinetes de curiosidades. Os colecionadores se especializaram e, a partir do século XVIII, surgiram os primeiros museus científicos. No final do século XIX, as exposições universais expunham a "barbárie" dos povos colonizados. Já as vanguardas do século XX redescobriram a arte "primitiva" enquanto fonte de renovação. Este artigo recupera tais formas de apreensão da cultura material de sociedades tradicionais ao longo do tempo, para chegar à inauguração do Musée Branly, em 2006. A partir desse museu, podem-se repensar algumas questões fundamentais acerca da arte "primitiva", como a dicotomia entre tratar os artefatos como testemunhos etnográficos ou como criações estéticas; as relações de poder envolvidas na aquisição dos objetos; o problema da autenticidade, numa era em que se multiplicam os souvenirs étnicos "neotradicionais".In the epoch of overseas discoveries, Europeans accumulated fragments of the realities they found in cabinets of curiosities. The private collectors specialized in different branches of "natural history" and this led to the emergence of scientific museums in the 18th century. At the end of the 19th century, universal exhibitions displayed "primitive" artifacts side by side with Western technologies, suggesting the "barbarism" of colonized peoples. But, at the beginning of the 20th century, the avant-gardes rediscovered the art nègre, using it as a source of artistic renovation. This article begins by describing these various forms of dealing with the cultural expressions of others, in order to understand the meaning of the recently opened Musée Branly. The French museum, devoted to non-occidental societies, provides an opportunity to reconsider some fundamental issues. Should we exhibit these artifacts as ethnographic testimonies or works of art? Can we

  4. Testing patients during seizures: A European consensus procedure developed by a joint taskforce of the ILAE - Commission on European Affairs and the European Epilepsy Monitoring Unit Association.

    Science.gov (United States)

    Beniczky, Sándor; Neufeld, Miri; Diehl, Beate; Dobesberger, Judith; Trinka, Eugen; Mameniskiene, Ruta; Rheims, Sylvain; Gil-Nagel, Antonio; Craiu, Dana; Pressler, Ronit; Krysl, David; Lebedinsky, Angelina; Tassi, Laura; Rubboli, Guido; Ryvlin, Philippe

    2016-09-01

    There is currently no international consensus procedure for performing comprehensive periictal testing of patients in the epilepsy monitoring units (EMUs). Our primary goal was to develop a standardized procedure for managing and testing patients during and after seizures in EMUs. The secondary goal was to assess whether it could be implemented in clinical practice (feasibility). A taskforce was appointed by the International League Against Epilepsy (ILAE)-Commission on European Affairs and the European Epilepsy Monitoring Unit Association, to develop a standardized ictal testing battery (ITB) based on expert opinion and experience with various local testing protocols. ITB contains a comprehensive set of 10 items that evidence the clinically relevant semiologic features, and it is adaptive to the dynamics of the individual seizures. The feasibility of the ITB was prospectively evaluated on 250 seizures from 152 consecutive patients in 10 centers. ITB was successfully implemented in clinical practice in all 10 participating centers and was considered feasible in 93% of the tested seizures. ITB was not feasible for testing seizures of very short duration.

  5. The Evolving Contingency Contracting Market: Private Sector Self regulation and United States Government Monitoring of Procurement of Stability Operations Services

    Science.gov (United States)

    2016-01-01

    focused on sex trafficking . In recent years, there has been a pronounced shift to- wards labor trafficking . Legal guest workers are at risk of being...allegations of Trafficking in Persons (TIP)5. In 2002, the United States adopted a zero tolerance TIP policy regarding U.S. government employees and... trafficking and improving security and risk control through local engagement. Finally, the paper concludes with a discussion of government-led re

  6. Bispectral index monitoring in the management of sedation in an intensive care unit patient with locked-in syndrome.

    Science.gov (United States)

    Quraishi, Sadeq A; Blosser, Sandralee A; Cherry, Robert A

    2011-11-01

    Locked-in syndrome is an extremely rare neurological state caused by injury of the ventral pons. The syndrome is characterized by quadriplegia and anarthria with concomitant preservation of cortical function. When a reversible underlying pathological abnormality is identified and managed aggressively, meaningful recovery is possible. Because patients retain consciousness throughout their illness, a dependable method for titrating sedation may improve their quality of life. The case presented suggests that bispectral index monitoring may be a cost-effective and reliable method for managing sedation in patients with locked-in syndrome.

  7. Monitoring storm tide and flooding from Hurricane Sandy along the Atlantic coast of the United States, October 2012

    Science.gov (United States)

    McCallum, Brian E.; Wicklein, Shaun M.; Reiser, Robert G.; Busciolano, Ronald J.; Morrison, Jonathan; Verdi, Richard J.; Painter, Jaime A.; Frantz, Eric R.; Gotvald, Anthony J.

    2013-01-01

    The U.S. Geological Survey (USGS) deployed a temporary monitoring network of water-level and barometric pressure sensors at 224 locations along the Atlantic coast from Virginia to Maine to continuously record the timing, areal extent, and magnitude of hurricane storm tide and coastal flooding generated by Hurricane Sandy. These records were greatly supplemented by an extensive post-flood high-water mark (HWM) flagging and surveying campaign from November to December 2012 involving more than 950 HWMs. Both efforts were undertaken as part of a coordinated federal emergency response as outlined by the Stafford Act under a directed mission assignment by the Federal Emergency Management Agency (FEMA).

  8. Annual Post-Closure Inspection and Monitoring Report for Corrective Action Unit 329: Area 22 Desert Rock Airstrip Fuel Spill, Nevada Test Site, Nevada, Rev. No.: 0

    Energy Technology Data Exchange (ETDEWEB)

    Alfred Wickline

    2006-09-01

    This report presents the data collected during field activities and quarterly soil-gas sampling activities conducted from May 9, 2005, through May 20, 2006, at Corrective Action Unit (CAU) 329, Area 22 Desert Rock Airstrip (DRA) Fuel Spill; Corrective Action Site (CAS) 22-44-01, Fuel Spill. The CAU is located at the DRA, which is located approximately two miles southwest of Mercury, Nevada, as shown in Figure 1-1. Field activities were conducted in accordance with the revised sampling approach outlined in the Addendum to the Closure Report (CR) for CAU 329 (NNSA/NSO, 2005) to support data collection requirements. The previous annual monitoring program for CAU 329 was initiated in August 2000 using soil-gas samples collected from three specific intervals at the DRA-0 and DRA-3 monitoring wells. Results of four sampling events from 2000 through 2003 indicated there is uncertainty in the approach to establish a rate of natural attenuation as specified in ''Streamlined Approach for Environmental Restoration (SAFER) Work Plan for Corrective Action Unit 329: Area 22 Desert Rock Airstrip Fuel Spill, Nevada Test Site, Nevada'' (DOE/NV, 1999). As a result, the Addendum to the CR (NNSA/NSO, 2005) was completed to address this uncertainty by modifying the previous approach. A risk evaluation was added to the scope of the project to determine if the residual concentration of the hazardous constituents of JP4 pose an unacceptable risk to human health or the environment and if a corrective action was required at the site, because the current quarterly monitoring program is not expected to yield a rate constant that could be used effectively to determine a biodegradation rate for total petroleum hydrocarbons (TPH) in less than the initial five years outlined in the CR. Additionally, remediation to the Tier 1 action level for TPH is not practical or technically feasible due to the depth of contamination.

  9. Comparing the monitoring of patients transferred from a critical care unit to hospital wards at after-hours with day transfers: an exploratory, prospective cohort study.

    Science.gov (United States)

    Wood, Sally D; Coster, Samantha; Norman, Ian

    2014-12-01

    To investigate possible factors related to patient monitoring to explain the higher mortality rates associated with after-hours transfers compared with daytime transfers from critical care units to the wards. International research suggests that patients transferred from critical care units after-hours have a higher mortality rate than transfers during daytime, although the reasons remain unknown. A prospective exploratory study. Twenty-nine patients transferred from a UK critical care unit to a ward within the same hospital after-hours for 10 weeks beginning April 2009 were compared with 29 transfers during daytime hours matched on potentially confounding characteristics. UK Critical Care Unit transfer guidelines have remained unchanged since data collection. Outcomes were as follows: (i) frequency of nursing observations; (ii) time periods from transfer to first medical review; (iii) time period from transfer to first clinical observations; (iv) frequency of transfer to an inappropriate ward; (v) delayed transfers from Critical Care Unit to ward. Using Wilcoxon's Rank test (two tail) to compare paired data from the matched groups, observations were recorded significantly less frequently within the first 12 hours for after-hours transfers. Time from transfer to first clinical observations was significantly longer for after-hour transfer patients. The delay from when the patient was ready for ward care and actual transfer was also longer for the after-hours transfer group. Surveillance differences, including time to the first set of observations and frequency of observations in the first 12 hours, are potential factors that may explain the differential mortality associated with after-hours transfers. © 2014 John Wiley & Sons Ltd.

  10. 32 × 32 silicon electro-optic switch with built-in monitors and balanced-status units

    Science.gov (United States)

    Qiao, Lei; Tang, Weijie; Chu, Tao

    2017-02-01

    To construct large-scale silicon electro-optical switches for optical interconnections, we developed a method using a limited number of power monitors inserted at certain positions to detect and determine the optimum operating points of all switch units to eliminate non-uniform effects arising from fabrication errors. We also introduced an optical phase bias to one phase-shifter arm of a Mach–Zehnder interferometer (MZI)-type switch unit to balance the two operation statuses of a silicon electro-optical switch during push–pull operation. With these methods, a 32 × 32 MZI-based silicon electro-optical switch was successfully fabricated with 180-nm complementary metal–oxide–semiconductor (CMOS) process technology, which is the largest scale silicon electro-optical switch to the best of our knowledge. At a wavelength of 1520 nm, the on-chip insertion losses were 12.9 to 16.5 dB, and the crosstalk ranged from ‑17.9 to ‑24.8 dB when all units were set to the ‘Cross’ status. The losses were 14.4 to 18.5 dB, and the crosstalk ranged from ‑15.1 to ‑19.0 dB when all units were in the ‘Bar’ status. The total power consumptions of the 32 × 32 switch were 247.4 and 542.3 mW when all units were set to the ‘Cross’ and ‘Bar’ statuses, respectively.

  11. Spermatogenic structure and fertility of Mus musculus after exposure of mangosteen (Garcinia mangostana L) pericarp extract

    Science.gov (United States)

    Hayati, Alfiah; Agustin, Melia Eka; Rokhimaningrum, Farida Ayu; Adro'i, Hasan; Darmanto, Win

    2016-03-01

    This study aimed to determine the effect of mangosteen (Garcinia mangostana L.) pericarp extract on spermatogenics number, seminiferous tubules sized, profile protein of epididymal and testicular sperm, and fertility of mice (Mus musculus). Fourty two male mice strain BALB/C was divided equally into 7 groups. The control group was given 0.05 ml of 0.05% CMC solution. Three group were given mangosteen pericarp extract at various doses (75, 100 and 150 mg/kg body weight, respectively) for 7 days, while the other three groups were given the same extract dose for 35 days. Parameters evaluated on histological of spermatogonia, spermatocytes, round spermatids, seminiferous tubule diameter, and thickness of germinal epithelium, analysis of testicular and epidydimal protein profile with SDS-Page, and than fertility test on female mice. The results showed that mangosteen pericarp extract at 75 and 100 mg/kg dose for 7 days had no effect on spermatogenics number and seminiferous tubule sizes, but the treatment dose of 150 mg/kg for 7 days and all treatment (doses of 75, 100, and 150 mg/kg) for 35 days led to significant decrease on the number of spermatogenics and seminiferous tubule sizes; effect on protein profiles testicular and epididymal sperm; and lower fertilization.

  12. The mouse (Mus musculus) T cell receptor alpha (TRA) and delta (TRD) variable genes.

    Science.gov (United States)

    Bosc, Nathalie; Lefranc, Marie-Paule

    2003-01-01

    'The Mouse (Mus musculus) T cell receptor alpha (TRA) and delta (TRD) variable genes' 'IMGT Locus in Focus' report provides the first complete list of the mouse TRAV and TRDV genes which span 1550 kb on chromosome 14 at 19.7 cM. The total number of TRAV genes per haploid genome is 98 belonging to 23 subgroups. This includes 10 TRAV/DV genes which belong to seven subgroups. The functional TRAV genomic repertoire comprises 72-82 TRAV (including 9-10 TRAV/DV) belonging to 19 subgroups. The total number of TRDV genes per haploid genome is 16 (including the 10 TRAV/DV) belonging to 12 subgroups. The functional TRDV genomic repertoire comprises 14-15 genes (5 TRDV and 9-10 TRAV/DV) belonging to 11-12 subgroups. The eight tables and three figures of this report are available at the IMGT Marie-Paule page of IMGT. The international ImMunoGeneTics information system (http://imgt.cines.fr) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, France.

  13. Effect of Physalis peruviana "tomatillo" fruit extract in Mus musculus var. swis with induced hyperlipidemi.

    Directory of Open Access Journals (Sweden)

    Julio Campos Florián

    2011-06-01

    Full Text Available The objective of this research was to determine the hypolipidemic activity of the fruit of Physalis peruviana "tomatillo" in a model of acute hyperlipidemia induced by triton. Mus musculus var. swis males as experimental animals. We worked with four groups of mice, the white group received distilled water orally and saline intraperitoneally, the control group received distilled water orally and intraperitoneally triton, the problem group 1 received orally 0.05g/100g Physalis peruviana extract intraperitoneally and triton and the problem group 2 received orally 0.2g/100g extract of Physalis peruviana and triton intraperitoneally. After 24 hours of administering the treatments were performed measurements of serum cholesterol and triglycerides. Mean levels of cholesterol (mg/dL were: 58.87 ± 11.54 (white, 121.71 ± 15.00 (control, 58.08 ± 9.21 (Problem 1 and 66 78 ± 16.77 (Problem 2. Average levels of triglycerides (g /L were: 0.48 ± 0.07 (white, 1.84 ± 0.18 (control, 0.34 ± 0.10 (Problem 1 and 0.94 ± 0.25 (Problem 2. We found significant reductions (p <0.000 concentrations of both cholesterol and triglycerides in relation to those obtained in the group treated only with Triton.

  14. Penelitian Pendahuluan Pengaruh Daun Manggis sebagai Rodentisida Nabati pada Mencit Mus musculus Strain Balepsi

    Directory of Open Access Journals (Sweden)

    Agus Kardinan

    2000-07-01

    Full Text Available Research has been conducted at Pest and Disease Laboratory, Research Institute for Spices and Medicinal Crops, Bogor, during 1997-1998. The objective was to evaluate the possibility of Mangosteen (Garcinia mangostana leaves to be used as botanical rodenticide which is tested to reproduction ability of mice Mus musculus. Eight to ten weeks old mice with the average weight of 25 gram were obtained from Research Institute for Livestock, Ciawi. Research was arranged at randomized block design, 8 treatments and 4 replications. Data was analyzed by determining the average value and their standard deviation values. Observations were done to the weight of testis, weight of embryo, number of embryo, volume of extracts drank by mice and mice behavior during experiment. Result revealed that there was no indication that the leaves extract affected the weight of testis, but it affected the number and weight of embryo. There was indication that mangosteen leaves acted as antifertility on mice. Giving leaves extract increased the total volume of extract drink. There was no abnormality at the activity of mice during experiment, included sex activity, poisonous symptoms and others.

  15. Meiosis and speciation: a study in a speciating Mus terricolor complex

    Indian Academy of Sciences (India)

    A. Bardhan; T. Sharma

    2000-01-01

    The three chromosomal species of the Mus terricolor complex possess $2n = 40$ chromosomes. We show that their karyotypes differ in stable heterochromatin variations fixed in homozygous condition as prominent short arms in auto-somes 1, 3 and 6. The three chromosomal species exhibit a high incidence of polymorphisms for Robertsonian fusions and pericentric inversions. Breeding experiments and histological analysis of testis show that heterozygosity for pericentric inversions and Robertsonian fusions had no effect on fertility. Meiotic analysis shows normal overall progression of meiosis in the heterozygotes, which is consistent with their normal gametogenesis. Nevertheless, both the inversion and fusion heterozygotes had undergone some alterations in the regular process of homologous synapsis, and it appeared that certain features of the meiotic system circumvented the potential negative effects of these polymorphic chromosomal rearrangements. The results indicate that the attributes of the meiotic system in a given organism could modulate the potential of a chromosomal rearrangement as reproductive barrier. The meiotic modulation hypothesis offers an explanation for the contradictory effects of the similar kinds of chromosomal mutations reported in different species.

  16. Molecular heterogeneity in major urinary proteins of Mus musculus subspecies: potential candidates involved in speciation

    Science.gov (United States)

    Hurst, Jane L.; Beynon, Robert J.; Armstrong, Stuart D.; Davidson, Amanda J.; Roberts, Sarah A.; Gómez-Baena, Guadalupe; Smadja, Carole M.; Ganem, Guila

    2017-01-01

    When hybridisation carries a cost, natural selection is predicted to favour evolution of traits that allow assortative mating (reinforcement). Incipient speciation between the two European house mouse subspecies, Mus musculus domesticus and M.m.musculus, sharing a hybrid zone, provides an opportunity to understand evolution of assortative mating at a molecular level. Mouse urine odours allow subspecific mate discrimination, with assortative preferences evident in the hybrid zone but not in allopatry. Here we assess the potential of MUPs (major urinary proteins) as candidates for signal divergence by comparing MUP expression in urine samples from the Danish hybrid zone border (contact) and from allopatric populations. Mass spectrometric characterisation identified novel MUPs in both subspecies involving mostly new combinations of amino acid changes previously observed in M.m.domesticus. The subspecies expressed distinct MUP signatures, with most MUPs expressed by only one subspecies. Expression of at least eight MUPs showed significant subspecies divergence both in allopatry and contact zone. Another seven MUPs showed divergence in expression between the subspecies only in the contact zone, consistent with divergence by reinforcement. These proteins are candidates for the semiochemical barrier to hybridisation, providing an opportunity to characterise the nature and evolution of a putative species recognition signal. PMID:28337988

  17. Electrical signals during nectar sucking in the carpenter ant Camponotus mus.

    Science.gov (United States)

    Josens, Roxana; Falibene, Agustina; Gontijo, Alberto de Figueiredo

    2006-01-01

    Ants of the same size can vary their intake rate of a given sucrose solution depending on the colony's needs for carbohydrates. As this capacity has not yet been described for another insect, the question of how they can do that was the focus of our work. When viscosity and ant-morphometry remain constant, changes in intake rate can only be attributed to the sucking forces. The aim of this study was to analyze the nectar sucking activity in the ant Camponotus mus. Feeding behavior seems to be under motivational control; therefore, we developed a non-invasive experimental device. We recorded the electrical signal generated during nectar feeding by offering ants sucrose solutions of different concentrations (from 10%w/w to 70%w/w). The signal frequency was between 2 and 12 peaks/s. We could distinguish two different patterns of electrical signal during feeding depending on the solution concentration. Only the more concentrated solutions reached frequencies higher than 7 peaks/s and the signal performance was quite irregular. For the other concentrations (10%, 30% and 50%), signal frequencies were lower than 6 peaks/s and the signal pattern was sinusoidal, regular and decreased with intake in all cases. We discuss the possible implications of these two signal patterns.

  18. Survey del parasitismo intestinal de las ratas grises (Mus norvegicus en la ciudad de Lima

    Directory of Open Access Journals (Sweden)

    Víctor M Ayulo R

    1947-12-01

    Full Text Available Hemos hecho un survey del parasitismo intestinal en 1,000 ratas grises (Mus norvegicus capturadas en la ciudad de Lima, llegando a las siguientes conclusiones: 1.- La incidencia del parasitismo intestinal en las ratas examinadas es de 87.30%. 2.- El 46.50% de estos roedores son portadores de protozoos intestinales. 3.- La incidencia de infestación con E. histolytica es muy baja: 1.7%. 4.- Las ratas examinadas en la ciudad de Lima son portadoras de Blastocystis hominis en el 18.4%. 5.- La incidencia de infestación con helmintos es 76.40%. 6.- Dada la gran infestación de las ratas grises con Hymenolepis nana, Hymenolepis diminuta, y Gigantorhynchus moniliformis, debemos considerar a estos roedores como reservorios potenciales en la trasmisión de estos parásitos al hombre, mientras otras investigaciones no excluyan a la rata gris como reservorio. 7.- El análisis estadístico de la frecuencia de infestación arroja un promedio o media de 2.11 ± 0.06 parásitos diferentes por rata y un coeficiente de variación de 78%. Los límites de infestación de las ratas examinadas oscilan entre 1 y 6 parásitos diferentes por animal.

  19. Nectar foraging behaviour is affected by ant body size in Camponotus mus.

    Science.gov (United States)

    Medan, Violeta; Josens, Roxana B

    2005-08-01

    The nectivorous ant Camponotus mus shows a broad size variation within the worker caste. Large ants can ingest faster and larger loads than small ones. Differences in physiological abilities in fluid ingestion due to the insect size could be related to differences in decision-making according to ant size during nectar foraging. Sucrose solutions of different levels of sugar concentration (30% or 60%w/w), viscosity (high or low) or flow rate (ad libitum or 1microl/min) were offered in combination to analyse the behavioural responses to each of these properties separately. Differences were found depending on ant body size and the property compared. A regulated flow produced smaller crop loads for medium and large ants compared to the same solution given ad libitum. All foragers remained longer times feeding at the regulated flow source but larger ants often made longer interruptions. When sugar concentration was constant but viscosity was high, only large ants increased feeding time. Constant viscosity with different sugar concentration determined longer feeding time and bigger loads for the most concentrated solution for small but not for large ants. Small ants reached similar crop loads in a variety of conditions while large ants did not. These differences could be evidence of a possible specialization for nectar foraging based on ant body size.

  20. Prevalence of Calodium hepaticum (Syn. Capillaria hepatica) in house mice (Mus musculus) in the Azores archipelago.

    Science.gov (United States)

    Resendes, A R; Amaral, A F S; Rodrigues, A; Almeria, S

    2009-03-23

    Calodium hepaticum (Syn. Capillaria hepatica) is a zoonotic liver nematode of mammals distributed worldwide. Rodents are believed to be the main reservoirs of this nematode. In this paper, prevalence of the parasite was analyzed in liver histological sections from 51 house mice (Mus musculus) caught in human-inhabited houses, from two localities (Furnas and Rabo de Peixe) on São Miguel island from the Azores archipelago (Portugal). Mean prevalence of infection was 19.6%, with 33.3% prevalence in Furnas and 4.1% in Rabo de Peixe (P=0.07). No significant differences were found between the prevalence of infection and the age, body weight and the sex of mice. Hepatic lesions found were either acute and/or chronic stage and consisted of moderate to severe multifocal pyogranulomatous hepatitis with encapsulated eggs with typical bipolar plugs and moderate to severe necrotizing hepatitis consistent with larva tracks. Periportal inflammatory infiltration, hepatocyte regeneration and bile duct hyperplasia were also noted. In most cases, hepatic lesions occupied more than 50% of the liver, but despite severe lesions, in some mice, no signs of hepatic failure were noticed. The high rate of infection found in the present study suggests that house mice are an important reservoir for this parasite in the Azores and could have a role in human transmission.

  1. Foraging decisions in wild versus domestic Mus musculus: What does life in the lab select for?

    Science.gov (United States)

    Troxell-Smith, Sandra M; Tutka, Michal J; Albergo, Jessica M; Balu, Deebika; Brown, Joel S; Leonard, John P

    2016-01-01

    What does domestication select for in terms of foraging and anti-predator behaviors? We applied principles of patch use and foraging theory to test foraging strategies and fear responses of three strains of Mus musculus: wild-caught, control laboratory, and genetically modified strains. Foraging choices were quantified using giving-up densities (GUDs) under three foraging scenarios: (1) patches varying in microhabitat (covered versus open), and initial resource density (low versus high); (2) daily variation in auditory cues (aerial predators and control calls); (3) patches with varying seed aggregations. Overall, both domestic strains harvested significantly more food than wild mice. Each strain revealed a significant preference for foraging under cover compared to the open, and predator calls had no detectable effects on foraging. Both domestic strains biased their harvest toward high quality patches; wild mice did not. In terms of exploiting favorable and avoiding unfavorable distributions of seeds within patches, the lab strain performed best, the wild strain worst, and the mutant strain in between. Our study provides support for hypothesis that domestic animals have more energy-efficient foraging strategies than their wild counterparts, but retain residual fear responses. Furthermore, patch-use studies can reveal the aptitudes and priorities of both domestic and wild animals.

  2. HISTOLOGI HATI MENCIT (Mus musculus L. YANG DIBERI EKSTRAK DAUN LAMTORO (Leucaena leucocephala

    Directory of Open Access Journals (Sweden)

    I Wayan Andi Yoga Kurniawan

    2014-09-01

    Full Text Available Leucaena (Leucaena leucocephala has been used as traditional medicine, such asdrugs to decrease the level of blood glucose, so it can be used as drug to indicatediabetes. The aim of this research is to study the histopathological change of mice’s livergiven leucaena leaf extract. This research used 24 male mice that were divided into 4 groupsby completely randomized design. Group P0 (control were given 0,9 % NaCl, and groupsP1, P2, and P3 were given 0,5 g / kg bw, 1 g / kg bw, and 1,5 g / kg bw leucaena’s leafextract by oral administration respectively. The treatment were given daily for 30 days. All ofthe mice were necropsied at day 31, and the liver were taken to examine theirhistopathological change. Histopathological change examination were based on the presenthydropic degeneration, fatty degeneration, and apoptosis surround central vein. Result ofstatistically analised by ANOVA and Kruskal-Wallis method indicated no significancedifference among the control and treatments. There was no significance toxicity effect ofleucaena leaf extract of all treatment dosage on mice liver.Keywords: Leucaena leucocephala, liver histology, Mus musculus L.

  3. MusA: Using Indoor Positioning and Navigation to Enhance Cultural Experiences in a Museum

    Directory of Open Access Journals (Sweden)

    Irene Rubino

    2013-12-01

    Full Text Available In recent years there has been a growing interest in the use of multimedia mobile guides in museum environments. Mobile devices have the capabilities to detect the user context and to provide pieces of information suitable to help visitors discover and follow the logical and emotional connections that develop during the visit. In this scenario, location based services (LBS currently represent an asset, and the choice of the technology to determine users’ position, combined with the definition of methods that can effectively convey information, become key issues in the design process. In this work, we present Museum Assistant (MusA, a general framework for the development of multimedia interactive guides for mobile devices. Its main feature is a vision-based indoor positioning system that allows the provision of several LBS, from way-finding to the contextualized communication of cultural contents, aimed at providing a meaningful exploration of exhibits according to visitors’ personal interest and curiosity. Starting from the thorough description of the system architecture, the article presents the implementation of two mobile guides, developed to respectively address adults and children, and discusses the evaluation of the user experience and the visitors’ appreciation of these applications.

  4. Skin fragility in the wild-derived, inbred mouse strain Mus pahari/EiJ.

    Science.gov (United States)

    Herbert Pratt, C; Potter, Christopher S; Kuiper, Raoul V; Karst, Son Yong; Dadras, Soheil S; Roopenian, Derry C; Sundberg, John P

    2017-02-01

    Mus pahari is a wild-derived, inbred mouse strain. M. pahari colony managers observed fragility of this strain's skin resulting in separation of tail skin from the mouse if handled incorrectly. Tail skin tension testing of M. pahari resulted in significantly lowered force threshold for caudal skin rupture and loss in comparison to closely related inbred mouse species and subspecies and even more than a model for junctional epidermolysis bullosa. Histologically, the tail skin separated at the subdermal level with the dermis firmly attached to the epidermis, excluding the epidermolysis bullosa complex of diseases. The dermal collagen bundles were abnormally thickened and branched. Elastin fiber deposition was focally altered in the dermis adjacent to the hair follicle. Collagens present in the skin could not be differentiated between the species in protein gels following digestion with pepsin. Together these data suggest that M. pahari have altered extracellular matrix development resulting in separation of the skin below the level of the dermis with moderate force similar to the African spiny mouse (Acomys spp.). Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Buah Mengkudu (Morinda citrifolia Meningkatkan Respon Imun Mencit (Mus musculus Terhadap Infeksi Bakteri Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Mufidah Zumrotul

    2015-11-01

    Full Text Available Noni (Morinda citrifolia Increase Immune Response in Mice (Mus musculus Infected Staphylococcus aureus. Infection disease caused by bacteria is one of the illness in several developing countries including in Indonesia, with high mortality rate. Infection of  S. aureus as the cause of problem resistance for antibiotic or multi drug resistance are giving the therapy of drug itself with change to medical herbal. The aim of this study is known the role of M.citrifolia extract to increase immune response of mice with infectioned of S. aureus. Mice were divided into two groups there are Non Infection and infection. Non Infection is without S. aureus and than infection has S. aureus. The each groups are including control, dose 1 (25 mg/kg BW, dose 2 (100 mg/kg BW, and dose 3 (300 mg/kg BW. Relative number of lymphocyte T cell (CD4+ subsets was measured  using the BD FACSCaliburTM Flowcytometer. Data were analyzed using Analysis of Varians (p<0,05 and using SPSS 16 for windows. The result showed that administration of  M. citrifolia crude extract in non infection groups was significantly increase the relative amounts T cell subsets (CD4+. Noni fruit extract can used as prevention therapy on infection disease of S. aureus bacteria because it contains active compounds that are anti-inflammation

  6. Ecological basis for fertility control in the house mouse (Mus domesticus) using immunocontraceptive vaccines.

    Science.gov (United States)

    Singleton, G R; Farroway, L N; Chambers, L K; Lawson, M A; Smith, A L; Hinds, L A

    2002-01-01

    Laboratory studies confirm the potential for fertility control in the house mouse Mus domesticus using mouse cytomegalovirus (MCMV) as a vector for an immunocontraceptive vaccine. This article presents an overview of key results from research in Australia on enclosed and field populations of mice and the associated epidemiology of MCMV. The virus is geographically widespread in Australia. It also persists in low population densities of mice, although if population densities are low for at least a year, transmission of the virus is sporadic until a population threshold of approximately 40 mice ha(-1) is reached. The serological prevalence of MCMV was high early in the breeding season of four field populations. Enclosure studies confirm that MCMV has minimal impact on the survival and breeding performance of mice and that it can be transmitted to most adults within 10-12 weeks. Other enclosure studies indicate that about two-thirds of females would need to be sterilized to provide effective control of the rate of growth of mouse populations. If this level is not maintained for 20-25 weeks after the commencement of breeding, the mouse population can compensate through increased recruitment per breeding female. The findings from this series of descriptive and manipulative population studies of mice support the contention that MCMV would be a good carrier for an immunocontraceptive vaccine required to sustain female sterility levels at or above 65%.

  7. Effects of classical music as part of environmental enrichment in captive Mus musculus (Rodentia: Muridae

    Directory of Open Access Journals (Sweden)

    José Geraldo Pereira da Cruz

    2010-06-01

    Full Text Available In the wild, animals are exposed to an ever-changing array of sensory stimuli. The captive environment, by contrast, is generally much more impoverished in terms of the cues it offers the animals housed within. In a bid to remedy this, and promote better welfare, mice (Mus musculus were exposed to two conditions: no auditory stimulation, and stimulation with classical music. In all experiments, a battery of behavior tests was used. The results demonstrated significantly decreased immobility in the forced swim, increased enclosed arm entries in the plus-maze, and decreased immobility in the open-field, in animals that had been pre-exposed to music 24h earlier, suggesting that changes in mouse motor activity were caused by classical music. This study led to the conclusion that environmental enrichment may have profound effects on the behavior of mice in behavioral tests, and that classical music can be a relatively simple method of contributing to the well-being of captive mice, but it can affect the results of experiments such as forced swimming.

  8. The French Muséum national d'histoire naturelle vascular plant herbarium collection dataset

    Science.gov (United States)

    Le Bras, Gwenaël; Pignal, Marc; Jeanson, Marc L.; Muller, Serge; Aupic, Cécile; Carré, Benoît; Flament, Grégoire; Gaudeul, Myriam; Gonçalves, Claudia; Invernón, Vanessa R.; Jabbour, Florian; Lerat, Elodie; Lowry, Porter P.; Offroy, Bérangère; Pimparé, Eva Pérez; Poncy, Odile; Rouhan, Germinal; Haevermans, Thomas

    2017-02-01

    We provide a quantitative description of the French national herbarium vascular plants collection dataset. Held at the Muséum national d'histoire naturelle, Paris, it currently comprises records for 5,400,000 specimens, representing 90% of the estimated total of specimens. Ninety nine percent of the specimen entries are linked to one or more images and 16% have field-collecting information available. This major botanical collection represents the results of over three centuries of exploration and study. The sources of the collection are global, with a strong representation for France, including overseas territories, and former French colonies. The compilation of this dataset was made possible through numerous national and international projects, the most important of which was linked to the renovation of the herbarium building. The vascular plant collection is actively expanding today, hence the continuous growth exhibited by the dataset, which can be fully accessed through the GBIF portal or the MNHN database portal (available at: https://science.mnhn.fr/institution/mnhn/collection/p/item/search/form). This dataset is a major source of data for systematics, global plants macroecological studies or conservation assessments.

  9. Quand l’artiste contemporain joue au muséographe

    Directory of Open Access Journals (Sweden)

    Noémie Drouguet

    2007-10-01

    Full Text Available L’article présente trois expositions consacrées à des thèmes dits de société, dont la muséographie a été entièrement confiée à des artistes contemporains. Il propose une réflexion sur l’apport particulier de ces intervenants inhabituels sur la conception de l’exposition, tant sur le plan de la forme que du contenu. En effet, les artistes renouvèlent les modes de présentation – à moins qu’ils ne s’inspirent du langage traditionnel de l’exposition – et abordent les sujets avec distance, humour ou provocation.This article deals with the intervention of contemporary artists in order to create themselves museography of exhibitions. Through the presentation of three study cases in society museums, the author shows what exhibitions language should get out of this artistic work, in both aspects of form and content - humorous, provocative or distant approach - even if the exhibition display could also be inspired by classical museal forms.

  10. Cytotoxicity evaluation of the whole protein extract from Bar-transgenic rice on Mus musculus lymphocytes.

    Science.gov (United States)

    Lu, X B

    2017-01-23

    With the expanding demand for genetically modified (GM) rice, its safety evaluation is of great significance. Therefore, this study was carried out to assess the acute cytotoxicity of the whole protein extract from GM rice Bar68-1 in Mus musculus lymphocytes in vitro. Cell viability was determined by Cell Counting Kit-8 (CCK-8) and Neutral Red Uptake (NRU) tests. CCK-8 tests was carried out according to the manufacturer's instructions. Cell dehydrogenase (catalytic redox enzymes) activity was spectrophotometrically determined at 450 nm. The tests result were recorded immediately. NRU tests were completed under yellow light in a dark room according to an improved protocol. Lysosomal uptake of neutral red was spectrophotometrically determined at 540 nm and the results were recorded immediately. The results showed that the survival rate of M. musculus lymphocytes in the positive control group was significantly less than in the blank control group (P tests. There was no significant difference in survival rate between GM rice Bar68-1group and non-GM rice D68 group (P > 0.05). The GM rice Bar68-1 group also did not show a higher survival rate than non-GM rice D68 group (P > 0.05). These results suggested that the whole protein extract from Bar68-1 and D68 were equivalent in their cytotoxicity, and GM rice Bar68-1 had no acute cytotoxic effect on M. musculus lymphocytes in vitro.

  11. The French Muséum national d’histoire naturelle vascular plant herbarium collection dataset

    Science.gov (United States)

    Le Bras, Gwenaël; Pignal, Marc; Jeanson, Marc L.; Muller, Serge; Aupic, Cécile; Carré, Benoît; Flament, Grégoire; Gaudeul, Myriam; Gonçalves, Claudia; Invernón, Vanessa R.; Jabbour, Florian; Lerat, Elodie; Lowry, Porter P.; Offroy, Bérangère; Pimparé, Eva Pérez; Poncy, Odile; Rouhan, Germinal; Haevermans, Thomas

    2017-01-01

    We provide a quantitative description of the French national herbarium vascular plants collection dataset. Held at the Muséum national d’histoire naturelle, Paris, it currently comprises records for 5,400,000 specimens, representing 90% of the estimated total of specimens. Ninety nine percent of the specimen entries are linked to one or more images and 16% have field-collecting information available. This major botanical collection represents the results of over three centuries of exploration and study. The sources of the collection are global, with a strong representation for France, including overseas territories, and former French colonies. The compilation of this dataset was made possible through numerous national and international projects, the most important of which was linked to the renovation of the herbarium building. The vascular plant collection is actively expanding today, hence the continuous growth exhibited by the dataset, which can be fully accessed through the GBIF portal or the MNHN database portal (available at: https://science.mnhn.fr/institution/mnhn/collection/p/item/search/form). This dataset is a major source of data for systematics, global plants macroecological studies or conservation assessments. PMID:28195585

  12. MusA: using indoor positioning and navigation to enhance cultural experiences in a museum.

    Science.gov (United States)

    Rubino, Irene; Xhembulla, Jetmir; Martina, Andrea; Bottino, Andrea; Malnati, Giovanni

    2013-12-17

    In recent years there has been a growing interest in the use of multimedia mobile guides in museum environments. Mobile devices have the capabilities to detect the user context and to provide pieces of information suitable to help visitors discover and follow the logical and emotional connections that develop during the visit. In this scenario, location based services (LBS) currently represent an asset, and the choice of the technology to determine users' position, combined with the definition of methods that can effectively convey information, become key issues in the design process. In this work, we present Museum Assistant (MusA), a general framework for the development of multimedia interactive guides for mobile devices. Its main feature is a vision-based indoor positioning system that allows the provision of several LBS, from way-finding to the contextualized communication of cultural contents, aimed at providing a meaningful exploration of exhibits according to visitors' personal interest and curiosity. Starting from the thorough description of the system architecture, the article presents the implementation of two mobile guides, developed to respectively address adults and children, and discusses the evaluation of the user experience and the visitors' appreciation of these applications.

  13. Ceftriaxone-vancomycin drug toxicity reduction by VRP 1020 in Mus musculus mice.

    Science.gov (United States)

    Soni, Arvind; Chaudhary, Manu; Dwivedi, Vivek Kumar

    2009-05-01

    Drug toxicity is a common cause of liver injury and kidney failure. This study was designed to elucidate whether administration of high doses of Ceftriaxone or Vancomycin induce oxidative stress in liver as well as kidney, and to investigate the protective effects of VRP 1020 with fixed dose combination of ceftriaxone-vancomycin (Immunox-V). Twenty four Mus musculus mice (weighing 30 +/- 5 g) were divided into four groups containing six mice in each group. The activities of antioxidant enzymes such as superoxide dismutase, catalase and the level of malonaldialdehyde, as an marker of lipid per oxidation, were measured to evaluate oxidative stress in homogenates of the liver and renal tissue. Ceftriaxone or vancomycin administration significantly increased malonaldialdehyde levels (p VRP 1020 with FDC of Immunox-V injections caused significantly decreased malonaldialdehyde levels (pVRP 1020 with fixed dose combination of Immunox-V can prevent drug induced nephrotoxicity and oxidative stress which protects liver injury as well as renal tissue damage by reducing reactive oxygen species which improve the activities of free radical scavenging enzymes.

  14. Helminth fauna of Mus musculus Linnaeus, 1758 from the suburban area of Belgrade, Serbia

    Directory of Open Access Journals (Sweden)

    Kataranovski D.S.

    2008-01-01

    Full Text Available The helminth fauna of the house mouse (Mus musculus Linnaeus, 1758 was studied on the basis of 429 host individuals from the suburban area of Belgrade. Eleven helminth species were recorded: three cestode species - Catenotaenia pusilla, Rodentolepis fraterna, and Cysticercus (= Strobilocercus fasciolaris [larval stage of Taenia taeniaeformis (Batsch, 1821]; and eight nematode species - Heligmosomoides polygyrus, Syphacia sp., Aspiculuris tetraptera, Syphacia obvelata, Heterakis spumosa, Trichuris muris, Mastophorus muris, and Gongylonema sp. Within the general helminth fauna, H. polygyrus was found to be the most prevalent species (39.2% and caused the highest infection intensity. Prevalences of A. tetraptera, C. pusilla, and S. obvelata ranged from 12.8% to 6.1%, while the remaining species showed prevalences ranging from 4.9% (for Syphacia sp. to 0.2% (for Gongylonema sp.. All the species found in males were also present in females, with the exceptions of M. muris and Gongylonema sp. No significant differences were found between males and females regarding prevalence (P%, mean infection intensity (MI, or mean abundance (MA.

  15. SU-E-T-24: A Simple Correction-Based Method for Independent Monitor Unit (MU) Verification in Monte Carlo (MC) Lung SBRT Plans

    Energy Technology Data Exchange (ETDEWEB)

    Pokhrel, D; Badkul, R; Jiang, H; Estes, C; Kumar, P; Wang, F [UniversityKansas Medical Center, Kansas City, KS (United States)

    2014-06-01

    Purpose: Lung-SBRT uses hypo-fractionated dose in small non-IMRT fields with tissue-heterogeneity corrected plans. An independent MU verification is mandatory for safe and effective delivery of the treatment plan. This report compares planned MU obtained from iPlan-XVM-Calgorithm against spreadsheet-based hand-calculation using most commonly used simple TMR-based method. Methods: Treatment plans of 15 patients who underwent for MC-based lung-SBRT to 50Gy in 5 fractions for PTV V100%=95% were studied. ITV was delineated on MIP images based on 4D-CT scans. PTVs(ITV+5mm margins) ranged from 10.1- 106.5cc(average=48.6cc). MC-SBRT plans were generated using a combination of non-coplanar conformal arcs/beams using iPlan XVM-Calgorithm (BrainLAB iPlan ver.4.1.2) for Novalis-TX consisting of micro-MLCs and 6MV-SRS (1000MU/min) beam. These plans were re-computed using heterogeneity-corrected Pencil-Beam (PB-hete) algorithm without changing any beam parameters, such as MLCs/MUs. Dose-ratio: PB-hete/MC gave beam-by-beam inhomogeneity-correction-factors (ICFs):Individual Correction. For independent-2nd-check, MC-MUs were verified using TMR-based hand-calculation and obtained an average ICF:Average Correction, whereas TMR-based hand-calculation systematically underestimated MC-MUs by ∼5%. Also, first 10 MC-plans were verified with an ion-chamber measurement using homogenous phantom. Results: For both beams/arcs, mean PB-hete dose was systematically overestimated by 5.5±2.6% and mean hand-calculated MU systematic underestimated by 5.5±2.5% compared to XVMC. With individual correction, mean hand-calculated MUs matched with XVMC by - 0.3±1.4%/0.4±1.4 for beams/arcs, respectively. After average 5% correction, hand-calculated MUs matched with XVMC by 0.5±2.5%/0.6±2.0% for beams/arcs, respectively. Smaller dependence on tumor volume(TV)/field size(FS) was also observed. Ion-chamber measurement was within ±3.0%. Conclusion: PB-hete overestimates dose to lung tumor relative to

  16. INSTALLATION OF A POST-ACCIDENT CONFINEMENT HIGH-LEVEL RADIATION MONITORING SYSTEM IN THE KOLA NUCLEAR POWER STATION (UNIT 2) IN RUSSIA

    Energy Technology Data Exchange (ETDEWEB)

    GREENE,G.A.; GUPPY,J.G.

    1998-09-01

    This is the final report on the INSP project entitled, ``Post-Accident Confinement High-Level Radiation Monitoring System'' conducted by BNL under the authorization of Project Work Plan WBS 1.2.2.6 (Attachment 1). This project was initiated in February 1993 to assist the Russians in reducing risks associated with the continued operation of older Soviet-designed nuclear power plants, specifically the Kola VVER-440/230 Unit 2, through improved accident detection capability, specifically by the installation of a dual train high-level radiation detection system in the confinement of Unit 2 of the Kola NPP. The major technical objective of this project was to provide, install and make operational the necessary hardware inside the confinement of the Kola NPP Unit 2 to provide early and reliable warning of the release of radionuclides from the reactor into the confinement air space as an indication of the occurrence of a severe accident at the plant. In addition, it was intended to provide hands-on experience and training to the Russian plant workers in the installation, operation, calibration and maintenance of the equipment in order that they may use the equipment without continued US assistance as an effective measure to improve reactor safety at the plant.

  17. A double-risk monitoring and movement restriction policy for Ebola entry screening at airports in the United States.

    Science.gov (United States)

    Jacobson, Sheldon H; Yu, Ge; Jokela, Janet A

    2016-07-01

    This paper provides an alternative policy for Ebola entry screening at airports in the United States. This alternative policy considers a social contact tracing (SCT) risk level, in addition to the current health risk level used by the CDC. The performances of both policies are compared based on the scenarios that occur and the expected cost associated with implementing such policies. Sensitivity analysis is performed to identify conditions under which one policy dominates the other policy. This analysis takes into account that the alternative policy requires additional data collection, which is balanced by a more cost-effective allocation of resources.

  18. Quelques Armes Espagnoles au Musée d'Art et d'Histoire de Genève

    Directory of Open Access Journals (Sweden)

    Bosson, Clément

    1969-12-01

    Full Text Available LA collection des armes et armures du Musée d'Art et d'Histoire de Genève provient de l'ancien arsenal de la République. Cette collection est donc composée surtout de pièces qui avaient été utilisées par les soldats des corps de troupe de Genève et des officiers de la République et par les dépouilles des adversaires de la Cité. Les armuriers allemands -et particulièrement italiens- étaient les fournisseurs de l'Etat par l'intermédiaire de marchands établis en ville. C'est la raison pour laquelle les armes construites en Espagne sont peu nombreuses dans ce musée.

  19. Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1

    Directory of Open Access Journals (Sweden)

    Miguel eGonzalez Blanco

    2015-07-01

    Full Text Available Repair of DNA lesions through homologous recombination promotes the establishment of stable chromosomal interactions. Multiple helicases, topoisomerases and structure-selective endonucleases (SSEs act upon recombining joint molecules (JMs to disengage chromosomal connections and safeguard chromosome segregation. Recent studies on two conserved SSEs -MUS81 and Yen1/GEN1- uncovered multiple layers of regulation that operate to carefully tailor JM-processing according to specific cellular needs. Temporal restriction of SSE function imposes a hierarchy in pathway usage that ensures efficient JM processing while minimizing reciprocal exchanges between the recombining DNAs. Whereas a conserved strategy of fine-tuning SSE functions exists in different model systems, the precise molecular mechanisms to implement it appear to be significantly different. Here, we summarize the current knowledge on the cellular switches that are in place to control MUS81 and Yen1/GEN1 functions.

  20. Le nouveau musée de Yad Vashem et la commémoration des victimes homosexuelles du nazisme*

    OpenAIRE

    Régis Schlagdenhauffen-Maika

    2007-01-01

    Le 15 mars 2005, quelques semaines après les célébrations du soixantième anniversaire de la libération d’Auschwitz, a été inauguré le nouveau musée de l’histoire de l’Holocauste de Yad Vashem. « Yad Vashem est le mémorial du peuple juif en souvenir des six millions de Juifs assassinés et il est le symbole de la confrontation continue à la rupture engendrée par l’Holocauste ». Le musée suscite, selon une « perspective juive », l’empathie avec les martyrs et l’identification avec les héros. Grâ...

  1. Le nouveau musée de Yad Vashem et la commémoration des victimes homosexuelles du nazisme

    Directory of Open Access Journals (Sweden)

    Régis Schlagdenhauffen-Maika

    2007-09-01

    Full Text Available Le 15 mars 2005, quelques semaines après les célébrations du soixantième anniversaire de la libération d’Auschwitz, a été inauguré le nouveau musée de l’histoire de l’Holocauste de Yad Vashem. « Yad Vashem est le mémorial du peuple juif en souvenir des six millions de Juifs assassinés et il est le symbole de la confrontation continue à la rupture engendrée par l’Holocauste ». Le musée suscite, selon une « perspective juive », l’empathie avec les martyrs et l’identification avec les héros. Grâ...

  2. Surveillance and monitoring of white-tailed deer for chronic wasting disease in the northeastern United States

    Science.gov (United States)

    Evans, Tyler S.; Schuler, Krysten L.; Walter, William D.

    2014-01-01

    Chronic wasting disease (CWD) is a prion disease that affects both wild and captive cervid populations. In the past 45 y, CWD has spread from northern Colorado to all bordering states, as well as the midwestern United States (Midwest) and northeastern United States (Northeast), Canada, and South Korea. Because CWD is a relatively new issue for wildlife management agencies in the Northeast, we surveyed a representative (e.g., cervid biologist, wildlife veterinarian) from 14 states to gain a better understanding of state-specific surveillance measures. Between 2002 and 2012, New York (37,093) and Pennsylvania (35,324) tested the greatest number of harvested white-tailed deer Odocoileus virginianus in the Northeast. Additionally, the 14 states surveyed have tested 121,730 harvested deer, or approximately 15,216/y, since CWD was first detected in 2005. The most common tissues used by agencies in the Northeast for testing were retropharyngeal lymph nodes, which have been determined to be the most reliable in detecting CWD in cervids. Understanding CWD surveillance efforts at a regional scale can help to provide guidance for the development of new surveillance plans or the improvement of existing ones. Furthermore, collaborations among state and regional agencies in the Northeast may attempt to identify deficiencies in surveillance by state or subregion.

  3. Development of an Exhaled Breath Monitoring System with Semiconductive Gas Sensors, a Gas Condenser Unit, and Gas Chromatograph Columns

    Directory of Open Access Journals (Sweden)

    Toshio Itoh

    2016-11-01

    Full Text Available Various volatile organic compounds (VOCs in breath exhaled by patients with lung cancer, healthy controls, and patients with lung cancer who underwent surgery for resection of cancer were analyzed by gas condenser-equipped gas chromatography-mass spectrometry (GC/MS for development of an exhaled breath monitoring prototype system involving metal oxide gas sensors, a gas condenser, and gas chromatography columns. The gas condenser-GC/MS analysis identified concentrations of 56 VOCs in the breath exhaled by the test population of 136 volunteers (107 patients with lung cancer and 29 controls, and selected four target VOCs, nonanal, acetoin, acetic acid, and propanoic acid, for use with the condenser, GC, and sensor-type prototype system. The prototype system analyzed exhaled breath samples from 101 volunteers (74 patients with lung cancer and 27 controls. The prototype system exhibited a level of performance similar to that of the gas condenser-GC/MS system for breath analysis.

  4. Development of an Exhaled Breath Monitoring System with Semiconductive Gas Sensors, a Gas Condenser Unit, and Gas Chromatograph Columns.

    Science.gov (United States)

    Itoh, Toshio; Miwa, Toshio; Tsuruta, Akihiro; Akamatsu, Takafumi; Izu, Noriya; Shin, Woosuck; Park, Jangchul; Hida, Toyoaki; Eda, Takeshi; Setoguchi, Yasuhiro

    2016-11-10

    Various volatile organic compounds (VOCs) in breath exhaled by patients with lung cancer, healthy controls, and patients with lung cancer who underwent surgery for resection of cancer were analyzed by gas condenser-equipped gas chromatography-mass spectrometry (GC/MS) for development of an exhaled breath monitoring prototype system involving metal oxide gas sensors, a gas condenser, and gas chromatography columns. The gas condenser-GC/MS analysis identified concentrations of 56 VOCs in the breath exhaled by the test population of 136 volunteers (107 patients with lung cancer and 29 controls), and selected four target VOCs, nonanal, acetoin, acetic acid, and propanoic acid, for use with the condenser, GC, and sensor-type prototype system. The prototype system analyzed exhaled breath samples from 101 volunteers (74 patients with lung cancer and 27 controls). The prototype system exhibited a level of performance similar to that of the gas condenser-GC/MS system for breath analysis.

  5. Quelques espèces nouvelles d’hispides de Sumatra appartenant au Musée de Leyde

    NARCIS (Netherlands)

    Gestro, R.

    1897-01-01

    Sur le point d’entreprendre l’étude des Hispides recueillies à Sumatra par M. le Doct. E. Modigliani, j’ai demandé à M. Ritsema, le savant conservateur de la collection d’insectes du Musée de Leyde, la communication de quelques espèces dans le but de faciliter mon travail. Mon aimable collègue a bie

  6. Phylogeography of Chinese house mice (Mus musculus musculus/castaneus): distribution, routes of colonization and geographic regions of hybridization.

    Science.gov (United States)

    Jing, Meidong; Yu, Hon-Tsen; Bi, Xiaoxin; Lai, Yung-Chih; Jiang, Wei; Huang, Ling

    2014-09-01

    House mice (Mus musculus) are human commensals and have served as a primary model in biomedical, ecological and evolutionary research. Although there is detailed knowledge of the biogeography of house mice in Europe, little is known of the history of house mice in China, despite the fact that China encompasses an enormous portion of their range. In the present study, 535 house mice caught from 29 localities in China were studied by sequencing the mitochondrial D-loop and genotyping 10 nuclear microsatellite markers distributed on 10 chromosomes. Phylogenetic analyses revealed two evolutionary lineages corresponding to Mus musculus castaneus and Mus musculus musculus in the south and north, respectively, with the Yangtze River approximately representing the boundary. More detailed analyses combining published sequence data from mice sampled in neighbouring countries revealed the migration routes of the two subspecies into China: M. m. castaneus appeared to have migrated through a southern route (Yunnan and Guangxi), whereas M. m. musculus entered China from Kazakhstan through the north-west border (Xinjiang). Bayesian analysis of mitochondrial sequences indicated rapid population expansions in both subspecies, approximately 4650-9300 and 7150-14 300 years ago for M. m. castaneus and M. m. musculus, respectively. Interestingly, the migration routes of Chinese house mice coincide with the colonization routes of modern humans into China, and the expansion times of house mice are consistent with the development of agriculture in southern and northern China, respectively. Finally, our study confirmed the existence of a hybrid zone between M. m. castaneus and M. m. musculus in China. Further study of this hybrid zone will provide a useful counterpart to the well-studied hybrid zone between M. m. musculus and Mus musculus domesticus in central Europe.

  7. Mus81-Mms4 and Yen1 resolve a novel anaphase bridge formed by noncanonical Holliday junctions.

    Science.gov (United States)

    García-Luis, Jonay; Machín, Félix

    2014-12-03

    Downregulation of separase, condensin, Smc5/6, topoisomerase II and Cdc14 in Saccharomyces cerevisiae yields anaphase bridges formed by unresolved sister chromatids (SCBs). Here we report that the overlapping actions of the structure-selective endonucleases (SSEs) Mus81-Mms4/EME1 and Yen1/GEN1, but not Slx1-Slx4, are also essential to prevent the formation of spontaneous SCBs that depend on the homologous recombination pathway. We further show that the frequency of SCBs is boosted after mild replication stress and that they contain joint molecules enriched in non-canonical forms of the Holliday junction (HJ), including nicked-HJ (nHJ). We show that SCBs are mostly reversible upon activation of either Mus81-Mms4 or Yen1 in late anaphase, which is concomitant with the disappearance of non-canonical HJs and restoration of viable progeny. On the basis of these findings, we propose a model where unresolved recombination intermediates are a source of mitotic SCBs, and Mus81-Mms4 and Yen1 play a central role in their resolution in vivo.

  8. Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases.

    Science.gov (United States)

    Castor, Dennis; Nair, Nidhi; Déclais, Anne-Cécile; Lachaud, Christophe; Toth, Rachel; Macartney, Thomas J; Lilley, David M J; Arthur, J Simon C; Rouse, John

    2013-10-24

    Holliday junctions (HJs) are X-shaped DNA structures that arise during homologous recombination, which must be removed to enable chromosome segregation. The SLX1 and MUS81-EME1 nucleases can both process HJs in vitro, and they bind in close proximity on the SLX4 scaffold, hinting at possible cooperation. However, the cellular roles of mammalian SLX1 are not yet known. Here, we use mouse genetics and structure function analysis to investigate SLX1 function. Disrupting the murine Slx1 and Slx4 genes revealed that they are essential for HJ resolution in mitotic cells. Moreover, SLX1 and MUS81-EME1 act together to resolve HJs in a manner that requires tethering to SLX4. We also show that SLX1, like MUS81-EME1, is required for repair of DNA interstrand crosslinks, but this role appears to be independent of HJ cleavage, at least in mouse cells. These findings shed light on HJ resolution in mammals and on maintenance of genome stability. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

  9. Spontaneous and Vaccine-Induced Clearance of Mus Musculus Papillomavirus 1 Infection.

    Science.gov (United States)

    Jiang, Rosie T; Wang, Joshua W; Peng, Shiwen; Huang, Tsui-Chin; Wang, Chenguang; Cannella, Fabiana; Chang, Yung-Nien; Viscidi, Raphael P; Best, Simon R A; Hung, Chien-Fu; Roden, Richard B S

    2017-08-01

    Mus musculus papillomavirus 1 (MmuPV1/MusPV1) induces persistent papillomas in immunodeficient mice but not in common laboratory strains. To facilitate the study of immune control, we sought an outbred and immunocompetent laboratory mouse strain in which persistent papillomas could be established. We found that challenge of SKH1 mice (Crl:SKH1-Hrhr) with MmuPV1 by scarification on their tail resulted in three clinical outcomes: (i) persistent (>2-month) papillomas (∼20%); (ii) transient papillomas that spontaneously regress, typically within 2 months (∼15%); and (iii) no visible papillomas and viral clearance (∼65%). SKH1 mice with persistent papillomas were treated by using a candidate preventive/therapeutic naked-DNA vaccine that expresses human calreticulin (hCRT) fused in frame to MmuPV1 E6 (mE6) and mE7 early proteins and residues 11 to 200 of the late protein L2 (hCRTmE6/mE7/mL2). Three intramuscular DNA vaccinations were delivered biweekly via in vivo electroporation, and both humoral and CD8 T cell responses were mapped and measured. Previously persistent papillomas disappeared within 2 months after the final vaccination. Coincident virologic clearance was confirmed by in situ hybridization and a failure of disease to recur after CD3 T cell depletion. Vaccination induced strong mE6 and mE7 CD8(+) T cell responses in all mice, although they were significantly weaker in mice that initially presented with persistent warts than in those that spontaneously cleared their infection. A human papillomavirus 16 (HPV16)-targeted version of the DNA vaccine also induced L2 antibodies and protected mice from vaginal challenge with an HPV16 pseudovirus. Thus, MmuPV1 challenge of SKH1 mice is a promising model of spontaneous and immunotherapy-directed clearances of HPV-related disease.IMPORTANCE High-risk-type human papillomaviruses (hrHPVs) cause 5% of all cancer cases worldwide, notably cervical, anogenital, and oropharyngeal cancers. Since preventative HPV

  10. Using Vessel Monitoring System Data to Identify and Characterize Trips Made by Fishing Vessels in the United States North Pacific

    Science.gov (United States)

    Haynie, Alan C.

    2016-01-01

    Time spent fishing is the effort metric often studied in fisheries but it may under-represent the effort actually expended by fishers. Entire fishing trips, from the time vessels leave port until they return, may prove more useful for examining trends in fleet dynamics, fisher behavior, and fishing costs. However, such trip information is often difficult to resolve. We identified ~30,000 trips made by vessels that targeted walleye pollock (Gadus chalcogrammus) in the Eastern Bering Sea from 2008–2014 by using vessel monitoring system (VMS) and landings data. We compared estimated trip durations to observer data, which were available for approximately half of trips. Total days at sea were estimated with 5 million VMS records (timestamps and vessel locations), this study was as much about understanding and managing data errors as it was about characterizing trips. Missing VMS records were pervasive and they strongly influenced our approach. To understand implications of missing data on inference, we simulated removal of VMS records from trips. Removal of records straightened (i.e., shortened) vessel trajectories, and travel distances were underestimated, on average, by 1.5–13.4% per trip. Despite this bias, VMS proved robust for trip characterization and for improved quality control of human-recorded data. Our scrutiny of human-reported and VMS data advanced our understanding of the potential utility and challenges facing VMS users globally. PMID:27788174

  11. Aktivitas polisakarida krestin dari ekstrak Coriolus versicolor terhadap peningkatan antibodi Mus musculus akibat paparan Mycobacterium tuberculosis

    Directory of Open Access Journals (Sweden)

    Sri Puji Astuti Wahyuningsih

    2013-03-01

    Full Text Available This research aimed to know the bioactivity of polysaccharide krestin (PSK with a different timing on formation of mice antibodyexposed by Mycobacterium tuberculosis. Mycobacterium tuberculosis was used as infection agent that had an abilitiy to be imunogenicand to lead immune system responsses decreased. Polysaccharides krestin was used as immunopotentiator which had a role to activatemacrophage and stimulate B cell in order to produce antibody. This research involved 30 adult female mice of Mus musculus strain Balb/C in the age of 8 €“10 weeks and in the weight between of 30 €“40 g. Mice were divided into six groups, as follows: group K asa control, was added only aquades; group K+ as positive control, was added only PSK; group K- as negative control, was exposedby M. tuberculosis only; group P1 was added PSK before being exposed by M. tuberculosis; group P2 was added PSK after beingexposed by M. tuberculosis; group P3 was added PSK before and after being exposed by M. tuberculosis. Polysaccharides krestin wasadded by gavage with single dose of 500 μg and M. tuberculosis was exposed intraperitoneally with concentration of 5x108 bacteryper ml. The bioactivity of PSK was observed by formation antibody using indirect ELISA test. The results of research were the averageof OD value of K group was 0,590 ± 0,042, K+ group was 0.641 ± 0.025, K- group was 1.044 ± 0.054, P1 group was 1.032 ± 0.125,P2 group was 1.127 ± 0.042, P3 group was 1.230 ± 0.097. The conclusion of this research showed that the adding of PSK increasedmice formation antibody. The time of adding before and after being exposed M. tuberculosis was the most potential to raise antibodyproduction on mice.

  12. Context dependence of acorn handling by the Algerian mouse (Mus spretus)

    Science.gov (United States)

    Gallego, D.; Morán-López, T.; Torre, I.; Navarro-Castilla, Á.; Barja, I.; Díaz, M.

    2017-10-01

    Perceived predation risk and competition for acorns are expected to affect scatter-hoarding decisions by Algerian mice (Mus spretus). We manipulated both factors by means of predator fecal scents and ungulate exclosures. We hypothesized that high-risk perception and ungulate presence would promote acorn dispersal. In the former case, it would stimulate acorn mobilization to safe microhabitats rather than in situ consumption. In the latter, increased competition for acorns would promote their storage for later consumption. We also expected that mice would adapt their foraging behavior to previous experience modulating the strength of these effects. In the presence of ungulates, mice focused their foraging activities on food acquisition at the expenses of vigilant behaviors. However, a more efficient foraging did not entail enhanced dispersal services. Lack of anti-predatory cover in tree surroundings may have deterred mice from transporting seeds outside canopies. Increased risk interacted with previous experience. In control trees (no predator odor), mice confidence increased throughout the night resulting in decreased vigilance and enhanced acorn mobilization rates. In contrast, in risky conditions (trees with predator odor) mice maintained a base-line vigilant behavior. Contrary to our expectations, increased risk did not result in higher acorn mobilization, but the opposite. Again, the scarcity of safe microhabitats for mobilization may have been the underlying cause of this behavior. Our results show that successful acorn dispersal depends, at least partly, on plant-animal relationships that are beyond the oak-rodent mutualism. Thus, any conservation policy aimed at restoring natural regeneration of oaks should take into account the interaction network in which oak-rodent encounters are embedded. In addition, they suggest that mice incorporate direct and indirect cues of risks (habitat structure) through recent experience. A better understanding of this process

  13. Peningkatan Ketebalan Miokardium Mencit (Mus musculus L. Akibat Paparan Medan Listrik Tegangan Tinggi

    Directory of Open Access Journals (Sweden)

    Hendri Busman

    2013-09-01

    Full Text Available Development of high voltage power transmission line could be expected to harm humans or other living creatures. Research objective was to determine the effect of exposure tohigh-voltage electric field to the thickness of the left ventricular myocardium male mice (Mus musculus L.. The experiment was conducted at the Laboratory of Zoology Faculty of Mathematics and Natural Sciencesat the University of Lampung and Central Pathology Laboratory Regional Veterinary Investigation III Bandar Lampung, in June−November 2011. Research using completely randomized design with 4 treatments, replicated 6 times and divided into four groups.The control group (K was not given treatment, group 1 (P1 given exposure to 5 kV/m, group 2 (P2 given exposure to 6 kV/m and group 3 (P3 given exposure to 7 kV/m for 8 hours/day, to 37 days. Data were analyzed using analysis of variance. The results obtained thickness of the left ventricular myocardium of male mice at K1,329.83±173.29 μm; P1 at 1,507.50±109.24 μm; P2 at 1,536.70±103.42 μm, and P3 at 1,574.23±123.36 μm. There was an increase in the average thickness of the myocardium with increasing exposure to power an electric field with a statistical test obtained (p=0.019. In conclusion, there is a significant relationship between exposure to high-voltage electric field to change the size of the thickness of the left ventricular myocardium male mice, the higher the electric field exposure thicker left ventricular myocardium male mice.

  14. Food preferences and mound-building behaviour of the mound-building mice Mus spicilegus

    Science.gov (United States)

    Hölzl, Michaela; Krištofík, Ján; Darolová, Alžbeta; Hoi, Herbert

    2011-10-01

    Optimal foraging strategies and food choice are influenced by various factors, e.g. availability, size and caloric content of the food type and predation risk. However, food choice criteria may change when food is not eaten immediately but has to be carried to a storage site for later use. For example, handling time in terms of harvesting and transport time should be optimized, particularly when the risk of predation is high. Thus, it is not clear whether food selected by hoarding animals reflects their food preference due to intrinsic features of the food type, e.g. size, caloric or lipid content, or whether the food type selected is a compromise that also considers the handling time required for harvesting and transport. We investigate this question in relation to food hoarding behaviour in mound-building mice. In autumn, mound-building mice Mus spicilegus collect seeds and other plant material and cover it with soil. Such above-ground storage is quite unusual for rodents. Here, we investigated whether there is a relationship between the seed species preferred as building materials and those preferred for food. We conducted a seed preference test using three most collected weed species for mound building. Controlling factors like food availability or predation risk, mice prefer Setaria spp. as food, although Amaranthus spp. and Chenopodium spp. were preferentially harvested and stored. By including the availability of the three species, our experimental results were confirmed, namely, a clear preference for Setaria spp. Also, handling time and seed size revealed to influence plant choice.

  15. Sliver nanoparticles accelerate skin wound healing in mice (Mus musculus through suppression of innate immune system

    Directory of Open Access Journals (Sweden)

    Mohammad Saeed Heydarnejad

    2013-09-01

    Full Text Available   Objective(s: This study aimed to find the effects of silver nanoparticles (Ag-NPs (40 nm on skin wound healing in mice Mus musculus when innate immune system has been suppressed.   Materials and Methods: A group of 50 BALB/c mice of about 8 weeks (weighting 24.2±3.0 g were randomly divided into two groups: Ag-NPs and control group, each with 25 mice. Once a day at the same time, a volume of 50 microliters from the nanosilver solution (10ppm was applied to the wound bed in the Ag-NPs group while in the untreated (control group no nanosilver solution was used but the wound area was washed by a physiological solution. The experiment lasted for 14. Transforming growth factor beta (TGF-β, complement component C3, and two other immune system factors involving in inflammation, namely C-reactive protein (CRP and rheumatoid factor (RF in sera of both groups were assessed and then confirmed by complement CH50 level of the blood. Results: The results show that wound healing is a complex process involving coordinated interactions between diverse immunological and biological systems and that Ag-NPs significantly accelerated wound healing and reduce scar appearance through suppression of immune system as indicated by decreasing levels of all inflammatory factors measured in this study. Conclusion: Exposure of mice to Ag-NPs can result in significant changes in innate immune function at the molecular levels. The study improves our understanding of nanoparticle interaction with components of the immune system and suggests that Ag-NPs have strong anti-inflammatory effects on skin wound healing and reduce scarring.

  16. Genotoxic effects in wild rodents (Rattus rattus and Mus musculus) in an open coal mining area.

    Science.gov (United States)

    León, Grethel; Pérez, Lyda Espitia; Linares, Juan Carlos; Hartmann, Andreas; Quintana, Milton

    2007-06-15

    Coal is a mixture of a variety of compounds containing mutagenic and carcinogenic polycyclic aromatic hydrocarbons. Exposure to coal is considered as an important non-cellular and cellular source of reactive oxygen species that can induce DNA damage. In addition, spontaneous combustion can occur in coal mining areas, further releasing compounds with detrimental effects on the environment. In this study the comet assay was used to investigate potential genotoxic effects of coal mining activities in peripheral blood cells of the wild rodents Rattus rattus and Mus musculus. The study was conducted in a coal mining area of the Municipio de Puerto Libertador, South West of the Departamento de Cordoba, Colombia. Animals from two areas in the coal mining zone and a control area located in the Municipio de Lorica were investigated. The results showed evidence that exposure to coal results in elevated primary DNA lesions in blood cells of rodents. Three different parameters for DNA damage were assessed, namely, DNA damage index, migration length and percentage damaged cells. All parameters showed statistically significantly higher values in mice and rats from the coal mining area in comparison to the animals from the control area. The parameter "DNA Damage Index" was found to be most sensitive and to best indicate a genotoxic hazard. Both species investigated were shown to be sensitive indicators of environmental genotoxicity caused by coal mining activities. In summary, our study constitutes the first investigation of potential genotoxic effects of open coal mining carried out in Puerto Libertador. The investigations provide a guide for measures to evaluate genotoxic hazards, thereby contributing to the development of appropriate measures and regulations for more careful operations during coal mining.

  17. MicroRNA Expression Profiling in CCl4-Induced Liver Fibrosis of Mus musculus

    Directory of Open Access Journals (Sweden)

    Jeongeun Hyun

    2016-06-01

    Full Text Available Liver fibrosis is a major pathological feature of chronic liver diseases, including liver cancer. MicroRNAs (miRNAs, small noncoding RNAs, regulate gene expression posttranscriptionally and play important roles in various kinds of diseases; however, miRNA-associated hepatic fibrogenesis and its acting mechanisms are poorly investigated. Therefore, we performed an miRNA microarray in the fibrotic livers of Mus musculus treated with carbon-tetrachloride (CCl4 and analyzed the biological functions engaged by the target genes of differentially-expressed miRNAs through gene ontology (GO and in-depth pathway enrichment analysis. Herein, we found that four miRNAs were upregulated and four miRNAs were downregulated more than two-fold in CCl4-treated livers compared to a control liver. Eight miRNAs were predicted to target a total of 4079 genes. GO analysis revealed that those target genes were located in various cellular compartments, including cytoplasm, nucleolus and cell surface, and they were involved in protein-protein or protein-DNA bindings, which influence the signal transductions and gene transcription. Furthermore, pathway enrichment analysis demonstrated that the 72 subspecialized signaling pathways were associated with CCl4-induced liver fibrosis and were mostly classified into metabolic function-related pathways. These results suggest that CCl4 induces liver fibrosis by disrupting the metabolic pathways. In conclusion, we presented several miRNAs and their biological processes that might be important in the progression of liver fibrosis; these findings help increase the understanding of liver fibrogenesis and provide novel ideas for further studies of the role of miRNAs in liver fibrosis.

  18. Post-Closure Inspection and Monitoring Report for Corrective Action Unit 417: Central Nevada Test Area Surface, Hot Creek Valley, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-10-01

    This report presents results of data collected during the annual post-closure site inspection conducted at the Central Nevada Test Area, surface Corrective Action Unit (CAU) 417 in June 2009. The annual post-closure site inspection included inspections of the UC-1, UC-3, and UC-4 sites in accordance with the Post-Closure Monitoring Plan provided in the CAU 417 Closure Report (NNSA/NV 2001). The annual inspection conducted at the UC-1 Central Mud Pit (CMP) indicated that the site and soil cover were in good condition. Three new fractures were identified in the soil cover and were filled with bentonite chips during the inspection. The vegetation on the soil cover was adequate but showed signs of the area's ongoing drought. No issues were identified with the CMP fence, gate, or subsidence monuments. No issues were identified with the warning signs and monuments at the other two UC-1 locations

  19. Post-Closure Monitoring Report for Corrective Action Unit 339: Area 12 Fleet Operations Steam Cleaning Discharge Area Nevada Test Site, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    A. T. Urbon

    2001-08-01

    The Area 12 Fleet Operations Steam Cleaning site is located in the southeast portion of the Area 12 Camp at the Nevada Test Site (Figure 1). This site is identified in the Federal Facility Agreement and Consent Order (FFACO, 1996) as Corrective Action Site (CAS) 12-19-01 and is the only CAS assigned to Corrective Action Unit (CAU) 339. Post-closure sampling and inspection of the site were completed on March 23, 2001. Because of questionable representativeness and precision of the results, the site was resampled on June 12, 2001. Post-closure monitoring activities were scheduled biennially (every two years) in the Post-Closure Monitoring Plan provided in the December 1997 Closure Report for CAU 339: Area 12 Fleet Operations Steam Cleaning Discharge Area, Nevada Test Site (U.S. Department of Energy, Nevada Operations Office [DOE/NV], 1997). If after six years the rate of degradation appears to be so slow that the greatest concentration of total petroleum hydrocarbons (TPH) present at the site would not decay within 30 years of the site closure, the site will be reevaluated with consideration to enriching the impacted soil at the site to enhance the degradation process. A baseline for the site was established by sampling in 1997. Based on the recommendations from the 1999 post-closure monitoring report, samples were collected in 2000, earlier than originally proposed, because the 1999 sample results did not provide the expected decrease in TPH concentrations at the site. Sampling results from 2000 revealed favorable conditions for natural degradation at the CAU 339 site, but because of differing sample methods and heterogeneity of the soil, the data results from 2000 were not directly correlated with previous results. Post-closure monitoring activities for 2001 consisted of the following: Soil sample collection from three undisturbed plots (Plots A, B, and C, Figure 2); Sample analysis for TPH as oil and bio-characterization parameters (Comparative Enumeration Assay

  20. The optical emission nebulae in the vicinity of WR 48 (Theta Mus); True Wolf-Rayet ejecta or unconnected supernova remnant?

    CERN Document Server

    Stupar, M; Filipovic, M D

    2009-01-01

    During searches for new optical Galactic supernova remnants (SNRs) in the high resolution, high sensitivity Anglo-Australian Observatory/United Kingdom Schmidt Telescope (AAO/UKST) HAlpha survey of the southern Galactic plane, we uncovered a variety of filamentary and more diffuse, extensive nebular structures in the vicinity of Wolf-Rayet (WR) star 48 (Theta Muscae), only some of which were previously recognised. We used the double-beam spectrograph of the Mount Stromlo and Siding Spring Observatory (MSSSO) 2.3-m to obtain low and mid resolution spectra of selected new filaments and structures in this region. Despite spectral similarities between the optical spectra of WR star shells and SNRs, a careful assessment of the new spectral and morphological evidence from our deep HAlpha imagery suggests that the putative shell of Theta Mus is not a WR shell at all, as has been commonly accepted, but is rather part of a more complex area of large-scale overlapping nebulosities in the general field of the WR star. T...

  1. Comparison of aerosol optical depth of UV-B monitoring and research program (UVMRP), AERONET and MODIS over continental united states

    Science.gov (United States)

    Tang, Hongzhao; Chen, Maosi; Davis, John; Gao, Wei

    2013-06-01

    The concern about the role of aerosols as to their effect in the Earth-Atmosphere system requires observation at multiple temporal and spatial scales. The Moderate Resolution Imaging Spectroradiameters (MODIS) is the main aerosol optical depth (AOD) monitoring satellite instrument, and its accuracy and uncertainty need to be validated against ground based measurements routinely. The comparison between two ground AOD measurement programs, the United States Department of Agriculture (USDA) Ultraviolet-B Monitoring and Research Program (UVMRP) and the Aerosol Robotic Network (AERONET) program, confirms the consistency between them. The intercomparison between the MODIS AOD, the AERONET AOD, and the UVMRP AOD suggests that the UVMRP AOD measurements are suited to be an alternative ground-based validation source for satellite AOD products. The experiments show that the spatial-temporal dependency between the MODIS AOD and the UVMRP AOD is positive in the sense that the MODIS AOD compare more favorably with the UVMRP AOD as the spatial and temporal intervals are increased. However, the analysis shows that the optimal spatial interval for all time windows is defined by an angular subtense of around 1° to 1.25°, while the optimal time window is around 423 to 483 minutes at most spatial intervals. The spatial-temporal approach around 1.25° & 423 minutes shows better agreement than the prevalent strategy of 0.25° & 60 minutes found in other similar investigations.

  2. Post-Closure Inspection and Monitoring Report for Corrective Action Unit 417: Central Nevada Test Area Surface, Hot Creek Valley, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-03-01

    This report presents results of data collected during the annual post-closure site inspections conducted at the Central Nevada Test Area surface Corrective Action Unit (CAU) 417 in May 2011 and July 2012. The annual post-closure site inspections included inspections of the UC-1, UC-3, and UC-4 sites in accordance with the Post-Closure Monitoring Plan provided in the CAU 417 Closure Report (NNSA/NV 2001). The annual inspections conducted at the UC-1 Central Mud Pit (CMP) indicated that the site and soil cover were in good condition. No new fractures or extension of existing fractures were observed and no issues with the fence or gate were identified. The vegetation on the cover continues to look healthy, but the biennial vegetation survey conducted during the 2012 inspection indicated that the total foliar cover was slightly higher in 2009 than in 2012. This may be indicative of a decrease in precipitation observed during the 2-year monitoring period. The precipitation totaled 9.9 inches from July 1, 2010, through June 30, 2011, and 5 inches from July 1, 2011, through June 30, 2012. This decrease in precipitation is also evident in the soil moisture data obtained from the time domain reflectometry sensors. Soil moisture content data show that the UC-1 cover is performing as designed, and evapotranspiration is effectively removing water from the cover.

  3. Radial artery applanation tonometry for continuous non-invasive arterial pressure monitoring in intensive care unit patients: comparison with invasively assessed radial arterial pressure.

    Science.gov (United States)

    Meidert, A S; Huber, W; Müller, J N; Schöfthaler, M; Hapfelmeier, A; Langwieser, N; Wagner, J Y; Eyer, F; Schmid, R M; Saugel, B

    2014-03-01

    Radial artery applanation tonometry technology can be used for continuous non-invasive measurement of arterial pressure (AP). The purpose of this study was to evaluate this AP monitoring technology in intensive care unit (ICU) patients in comparison with invasive AP monitoring using a radial arterial catheter. In 24 ICU patients (German university hospital), AP values were simultaneously recorded on a beat-to-beat basis using radial artery applanation tonometry (T-Line system; Tensys Medical, San Diego, CA, USA) and a radial arterial catheter (contralateral arm). The primary endpoint of the study was to investigate the accuracy and precision of the non-invasively assessed AP measurements with the Bland-Altman method based on averaged 10 beat AP epochs (n=2993 10 beat epochs). For mean AP (MAP), systolic AP (SAP), and diastolic AP (DAP), we observed a bias (±standard deviation of the bias; 95% limits of agreement; percentage error) of +2 mm Hg (±6; -11 to +15 mm Hg; 15%), -3 mm Hg (±15; -33 to +27 mm Hg; 23%), and +5 mm Hg (±7; -9 to +19 mm Hg; 22%), respectively. In ICU patients, MAP and DAP measurements obtained using radial artery applanation tonometry show clinically acceptable agreement with invasive AP determination with a radial arterial catheter. While the radial artery applanation tonometry technology also allows SAP measurements with high accuracy, its precision for SAP measurements needs to be further improved.

  4. Noninvasive near-infrared blood glucose monitoring using a calibration model built by a numerical simulation method: Trial application to patients in an intensive care unit.

    Science.gov (United States)

    Maruo, Katsuhiko; Oota, Tomohiro; Tsurugi, Mitsuhiro; Nakagawa, Takehiro; Arimoto, Hidenobu; Hayakawa, Mineji; Tamura, Mamoru; Ozaki, Yukihiro; Yamada, Yukio

    2006-12-01

    We have applied a new methodology for noninvasive continuous blood glucose monitoring, proposed in our previous paper, to patients in ICU (intensive care unit), where strict controls of blood glucose levels are required. The new methodology can build calibration models essentially from numerical simulation, while the conventional methodology requires pre-experiments such as sugar tolerance tests, which are impossible to perform on ICU patients in most cases. The in vivo experiments in this study consisted of two stages, the first stage conducted on healthy subjects as preliminary experiments, and the second stage on ICU patients. The prediction performance of the first stage was obtained as a correlation coefficient (r) of 0.71 and standard error of prediction (SEP) of 28.7 mg/dL. Of the 323 total data, 71.5% were in the A zone, 28.5% were in the B zone, and none were in the C, D, and E zones for the Clarke error-grid analysis. The prediction performance of the second stage was obtained as an r of 0.97 and SEP of 27.2 mg/dL. Of the 304 total data, 80.3% were in the A zone, 19.7% were in the B zone, and none were in the C, D, and E zones. These prediction results suggest that the new methodology has the potential to realize a noninvasive blood glucose monitoring system using near-infrared spectroscopy (NIRS) in ICUs. Although the total performance of the present monitoring system has not yet reached a satisfactory level as a stand-alone system, it can be developed as a complementary system to the conventional one used in ICUs for routine blood glucose management, which checks the blood glucose levels of patients every few hours.

  5. Improved Analysis of Long-Term Monitoring Data Demonstrates Marked Regional Declines of Bat Populations in the Eastern United States.

    Directory of Open Access Journals (Sweden)

    Thomas E Ingersoll

    Full Text Available Bats are diverse and ecologically important, but are also subject to a suite of severe threats. Evidence for localized bat mortality from these threats is well-documented in some cases, but long-term changes in regional populations of bats remain poorly understood. Bat hibernation surveys provide an opportunity to improve understanding, but analysis is complicated by bats' cryptic nature, non-conformity of count data to assumptions of traditional statistical methods, and observation heterogeneities such as variation in survey timing. We used generalized additive mixed models (GAMMs to account for these complicating factors and to evaluate long-term, regional population trajectories of bats. We focused on four hibernating bat species - little brown myotis (Myotis lucifugus, tri-colored bat (Perimyotis subflavus, Indiana myotis (M. sodalis, and northern myotis (M. septentrionalis - in a four-state region of the eastern United States during 1999-2011. Our results, from counts of nearly 1.2 million bats, suggest that cumulative declines in regional relative abundance by 2011 from peak levels were 71% (with 95% confidence interval of ±11% in M. lucifugus, 34% (±38% in P. subflavus, 30% (±26% in M. sodalis, and 31% (±18% in M. septentrionalis. The M. lucifugus population fluctuated until 2004 before persistently declining, and the populations of the other three species declined persistently throughout the study period. Population trajectories suggest declines likely resulted from the combined effect of multiple threats, and indicate a need for enhanced conservation efforts. They provide strong support for a change in the IUCN Red List conservation status in M. lucifugus from Least Concern to Endangered within the study area, and are suggestive of a need to change the conservation status of the other species. Our modeling approach provided estimates of uncertainty, accommodated non-linearities, and controlled for observation heterogeneities, and

  6. Using search query surveillance to monitor tax avoidance and smoking cessation following the United States' 2009 "SCHIP" cigarette tax increase.

    Science.gov (United States)

    Ayers, John W; Ribisl, Kurt; Brownstein, John S

    2011-03-16

    Smokers can use the web to continue or quit their habit. Online vendors sell reduced or tax-free cigarettes lowering smoking costs, while health advocates use the web to promote cessation. We examined how smokers' tax avoidance and smoking cessation Internet search queries were motivated by the United States' (US) 2009 State Children's Health Insurance Program (SCHIP) federal cigarette excise tax increase and two other state specific tax increases. Google keyword searches among residents in a taxed geography (US or US state) were compared to an untaxed geography (Canada) for two years around each tax increase. Search data were normalized to a relative search volume (RSV) scale, where the highest search proportion was labeled 100 with lesser proportions scaled by how they relatively compared to the highest proportion. Changes in RSV were estimated by comparing means during and after the tax increase to means before the tax increase, across taxed and untaxed geographies. The SCHIP tax was associated with an 11.8% (95% confidence interval [95%CI], 5.7 to 17.9; ptax levels in Canada during the months after the tax. Tax avoidance searches increased 27.9% (95%CI, 15.9 to 39.9; ptax compared to Canada, respectively, suggesting avoidance is the more pronounced and durable response. Trends were similar for state-specific tax increases but suggest strong interactive processes across taxes. When the SCHIP tax followed Florida's tax, versus not, it promoted more cessation and avoidance searches. Efforts to combat tax avoidance and increase cessation may be enhanced by using interventions targeted and tailored to smokers' searches. Search query surveillance is a valuable real-time, free and public method, that may be generalized to other behavioral, biological, informational or psychological outcomes manifested online.

  7. Performance characterization of siemens primus linear accelerator under small monitor unit and small segments for the implementation of step-and-shoot intensitymodulated radiotherapy

    Directory of Open Access Journals (Sweden)

    Reena P

    2006-01-01

    Full Text Available Implementation of step-and-shoot intensity-modulated radiotherapy (IMRT needs careful understanding of the accelerator start-up characteristic to ensure accurate and precise delivery of radiation dose to patient. The dosimetric characteristic of a Siemens Primus linear accelerator (LA which delivers 6 and 18 MV x-rays at the dose rate of 300 and 500 monitor unit (MU per minutes (min respectively was studied under the condition of small MU ranging from 1 to 100. Dose monitor linearity was studied at different dose calibration parameter (D1_C0 by measuring ionization at 10 cm depth in a solid water phantom using a 0.6 cc ionization chamber. Monitor unit stability was studied from different intensity modulated (IM groups comprising various combinations of MU per field and number of fields. Stability of beam flatness and symmetry was investigated under normal and IMRT mode for 20x20 cm2 field under small MU using a 2D Profiler kept isocentrically at 5 cm depth. Inter segment response was investigated form 1 to 10 MU by measuring the dose per MU from various IM groups, each consisting of four segments with inter-segment separation of 2 cm. In the range 1-4 MU, the dose linearity error was more than 5% (max -32% at 1 MU for 6 MV x-rays at factory calibrated D1_C0 value of 6000. The dose linearity error was reduced to -10.95% at 1 MU, within -3% for 2 and 3 MU and ±1% for MU ≥4 when the D1_C0 was subsequently tuned at 4500. For 18 MV x-rays, the dose linearity error at factory calibrated D1_C0 value of 4400 was within ±1% for MU ≥ 3 with maximum of -13.5 observed at 1 MU. For both the beam energies and MU/field ≥ 4, the stability of monitor unit tested for different IM groups was within ±1% of the dose from the normal treatment field. This variation increases to -2.6% for 6 MV and -2.7% for 18 MV x-rays for 2 MU/field. No significant variation was observed in the stability of beam profile measured from normal and IMRT mode. The beam flatness

  8. Using search query surveillance to monitor tax avoidance and smoking cessation following the United States' 2009 "SCHIP" cigarette tax increase.

    Directory of Open Access Journals (Sweden)

    John W Ayers

    Full Text Available Smokers can use the web to continue or quit their habit. Online vendors sell reduced or tax-free cigarettes lowering smoking costs, while health advocates use the web to promote cessation. We examined how smokers' tax avoidance and smoking cessation Internet search queries were motivated by the United States' (US 2009 State Children's Health Insurance Program (SCHIP federal cigarette excise tax increase and two other state specific tax increases. Google keyword searches among residents in a taxed geography (US or US state were compared to an untaxed geography (Canada for two years around each tax increase. Search data were normalized to a relative search volume (RSV scale, where the highest search proportion was labeled 100 with lesser proportions scaled by how they relatively compared to the highest proportion. Changes in RSV were estimated by comparing means during and after the tax increase to means before the tax increase, across taxed and untaxed geographies. The SCHIP tax was associated with an 11.8% (95% confidence interval [95%CI], 5.7 to 17.9; p<.001 immediate increase in cessation searches; however, searches quickly abated and approximated differences from pre-tax levels in Canada during the months after the tax. Tax avoidance searches increased 27.9% (95%CI, 15.9 to 39.9; p<.001 and 5.3% (95%CI, 3.6 to 7.1; p<.001 during and in the months after the tax compared to Canada, respectively, suggesting avoidance is the more pronounced and durable response. Trends were similar for state-specific tax increases but suggest strong interactive processes across taxes. When the SCHIP tax followed Florida's tax, versus not, it promoted more cessation and avoidance searches. Efforts to combat tax avoidance and increase cessation may be enhanced by using interventions targeted and tailored to smokers' searches. Search query surveillance is a valuable real-time, free and public method, that may be generalized to other behavioral, biological

  9. Insights into the problem of alarm fatigue with physiologic monitor devices: a comprehensive observational study of consecutive intensive care unit patients.

    Science.gov (United States)

    Drew, Barbara J; Harris, Patricia; Zègre-Hemsey, Jessica K; Mammone, Tina; Schindler, Daniel; Salas-Boni, Rebeca; Bai, Yong; Tinoco, Adelita; Ding, Quan; Hu, Xiao

    2014-01-01

    Physiologic monitors are plagued with alarms that create a cacophony of sounds and visual alerts causing "alarm fatigue" which creates an unsafe patient environment because a life-threatening event may be missed in this milieu of sensory overload. Using a state-of-the-art technology acquisition infrastructure, all monitor data including 7 ECG leads, all pressure, SpO(2), and respiration waveforms as well as user settings and alarms were stored on 461 adults treated in intensive care units. Using a well-defined alarm annotation protocol, nurse scientists with 95% inter-rater reliability annotated 12,671 arrhythmia alarms. A total of 2,558,760 unique alarms occurred in the 31-day study period: arrhythmia, 1,154,201; parameter, 612,927; technical, 791,632. There were 381,560 audible alarms for an audible alarm burden of 187/bed/day. 88.8% of the 12,671 annotated arrhythmia alarms were false positives. Conditions causing excessive alarms included inappropriate alarm settings, persistent atrial fibrillation, and non-actionable events such as PVC's and brief spikes in ST segments. Low amplitude QRS complexes in some, but not all available ECG leads caused undercounting and false arrhythmia alarms. Wide QRS complexes due to bundle branch block or ventricular pacemaker rhythm caused false alarms. 93% of the 168 true ventricular tachycardia alarms were not sustained long enough to warrant treatment. The excessive number of physiologic monitor alarms is a complex interplay of inappropriate user settings, patient conditions, and algorithm deficiencies. Device solutions should focus on use of all available ECG leads to identify non-artifact leads and leads with adequate QRS amplitude. Devices should provide prompts to aide in more appropriate tailoring of alarm settings to individual patients. Atrial fibrillation alarms should be limited to new onset and termination of the arrhythmia and delays for ST-segment and other parameter alarms should be configurable. Because computer

  10. Insights into the problem of alarm fatigue with physiologic monitor devices: a comprehensive observational study of consecutive intensive care unit patients.

    Directory of Open Access Journals (Sweden)

    Barbara J Drew

    Full Text Available PURPOSE: Physiologic monitors are plagued with alarms that create a cacophony of sounds and visual alerts causing "alarm fatigue" which creates an unsafe patient environment because a life-threatening event may be missed in this milieu of sensory overload. Using a state-of-the-art technology acquisition infrastructure, all monitor data including 7 ECG leads, all pressure, SpO(2, and respiration waveforms as well as user settings and alarms were stored on 461 adults treated in intensive care units. Using a well-defined alarm annotation protocol, nurse scientists with 95% inter-rater reliability annotated 12,671 arrhythmia alarms. RESULTS: A total of 2,558,760 unique alarms occurred in the 31-day study period: arrhythmia, 1,154,201; parameter, 612,927; technical, 791,632. There were 381,560 audible alarms for an audible alarm burden of 187/bed/day. 88.8% of the 12,671 annotated arrhythmia alarms were false positives. Conditions causing excessive alarms included inappropriate alarm settings, persistent atrial fibrillation, and non-actionable events such as PVC's and brief spikes in ST segments. Low amplitude QRS complexes in some, but not all available ECG leads caused undercounting and false arrhythmia alarms. Wide QRS complexes due to bundle branch block or ventricular pacemaker rhythm caused false alarms. 93% of the 168 true ventricular tachycardia alarms were not sustained long enough to warrant treatment. DISCUSSION: The excessive number of physiologic monitor alarms is a complex interplay of inappropriate user settings, patient conditions, and algorithm deficiencies. Device solutions should focus on use of all available ECG leads to identify non-artifact leads and leads with adequate QRS amplitude. Devices should provide prompts to aide in more appropriate tailoring of alarm settings to individual patients. Atrial fibrillation alarms should be limited to new onset and termination of the arrhythmia and delays for ST-segment and other parameter

  11. Post-Closure Inspection and Monitoring Report for Corrective Action Unit 417: Central Nevada Test Area Surface, Hot Creek Valley, Nevada, for Calendar Year 2007

    Energy Technology Data Exchange (ETDEWEB)

    None

    2008-09-01

    This report presents data collected during the annual post-closure site inspection conducted at the Central Nevada Test Area Surface Corrective Action Unit (CAU) 417 in May 2007. The annual post-closure site inspection included inspections of the UC-1, UC-3, and UC-4 sites in accordance with the Post-Closure Monitoring Plan provided in the CAU 417 Closure Report (NNSA/NV 2001). The annual inspection conducted at the UC-1 Central Mud Pit (CMP) indicated the site and soil cover were in good condition. No new cracks or fractures were observed in the soil cover during the annual inspection. A crack on the west portion of the cover was observed during the last quarterly inspection in December 2006. This crack was filled with bentonite as part of the maintenance activities conducted in February 2007 and will be monitored during subsequent annual inspections. The vegetation on the soil cover was adequate but showing signs of the area's ongoing drought. No issues were identified with the CMP fence, gate, or subsidence monuments. New DOE Office of Legacy Management signs with updated emergency phone numbers were installed as part of this annual inspection, no issues were identified with the warning signs and monuments at the other two UC-1 locations. The annual subsidence survey was conducted at UC-1 CMP and UC-4 Mud Pit C as part of the maintenance activities conducted in February 2007. The results of the subsidence surveys indicate that the covers are performing as expected, and no unusual subsidence was observed. A vegetation survey of the UC-1 CMP cover and adjacent areas was conducted as part of the annual inspection in May 2007. The vegetation survey indicated that revegetation continues to be successful, although stressed due to the area's prevailing drought conditions. The vegetation should continue to be monitored to document any changes in the plant community and to identify conditions that could potentially require remedial action to maintain a viable

  12. POST-CLOSURE INSPECTION AND MONITORING REPORT FOR CORRECTIVE ACTION UNIT 91: AREA 3 U3fi INJECTION WELL, NEVADA TEST SITE, NEVADA FOR THE PERIOD NOVEMBER 2003 - OCTOBER 2004

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-01-01

    This Post-Closure Inspection and Monitoring report provides an analysis and summary of inspections, meteorological information, and neutron soil moisture monitoring for Corrective Action Unit (CAU) 91: Area 3 U-3fi Injection Well, Nevada Test Site (NTS), Nevada. This report covers the annual period November 2003 through October 2004. Site inspections of CAU 91 are performed every six months to identify any significant changes that could impact the proper operation of the waste disposal unit. Inspection results for the current period indicate that the overall condition of the concrete pad, perimeter fence, and warning signs is good.

  13. The Effect of Epinephrine On The Development of oogenesis Of Mice (Mus Musculus Strain of Japanese

    Directory of Open Access Journals (Sweden)

    Sri Utami

    2012-01-01

    Full Text Available When stress persists continuously and repeatedly, it will automatically increase the epinephrine in the body in which excessive consequently can provide interference on various body systems. In the event of physical stressors can affect the frequency and amplitude of pulsatile gonadotropin-releasing hormone (GnRH. It is important for the secretion of follicle-stimulating hormone (FSH and luteinizing hormone (LH. Additionally stressors can also activate the sympathetic nervous system. If the increase is excessive pulsation can reduce and stop the secretion of follicle-stimulating hormone (FSH and luteinizing hormone (LH. Decrease in Follicle-stimulating hormone (FSH and luteinizing hormone (LH will inhibit the growth of ovarian follicles and decrease the synthesis of estrogen and progesterone in the ovaries. Decreased synthesis of estrogen and progesterone can cause a decrease in the number of ovarian follicles (Speroff, 1994.The study population was female mice derived from laboratory Biomedic Andalas University in Padang. Mice used were 2-3 months old, weighing an average of 25-35 grams. The Effect of Epinephrine on the Development of Oogenesis of Mice (mus musculus Strain of Japanese, is the growth of primary follicles in which a decline in the number of primary follicles ranging from provision of 0.002 mg / ml, epinephrine administration lowered formation of secondary follicles at a concentration of 0.004 mg / ml and above but no decrease in concentration of 0.002 mg / ml, epinephrine administration lowered formation of tertiary follicles at a concentration of 0.004 mg / ml, 0.006 mg / ml, 0.008 mg / ml and 0.01 mg / ml and no decrease in concentration of 0.002 mg / ml, epinephrine administration did not reduce the formation of follicle de Graaf and administration of epinephrine significantly reduce the formation of the corpus luteum at a concentration of 0.004 mg / ml, 0.006 mg / ml, 0.008 mg / ml and 0.01 mg / ml and no decrease in

  14. Le Musée du bagne en Nouvelle-Calédonie et ses constructions identitaires

    Directory of Open Access Journals (Sweden)

    Fanny Cecile Pascual

    2017-10-01

    Full Text Available In the South Pacific, New Caledonia and Australia were penal colonies during the 19th century. Analysing the discourse surrouding two museums based on these convict periods (Hyde Park Barracks in Sydney and the project for a museum in Noumea, will shed light on the difficulties of facing this violent past. Even if these two countries and their histories are different, they have a common aim to accept this part of their genealogies. After having been taboo, having criminal ancestors is now a pride; exile is no more seen as an expulsion from the English or French motherland, but has become a pioneer adventure. Suppressing some aspects of this colonisation and downplaying the participation or the interactions of convicts or bagnards with other communities helps to build this memory. We must also keep in mind that museums have a political role. In New Caledonia, it is obvious that the self-determination process between 2014 and 2018 has influenced the project of the museum in Nouville: having a convict in the family will prove your belonging to the land and could justify voting rights for the 2018 referendum. These museums accordingly do not only deal with history, but influence the future. Au XIXème siècle, la Nouvelle-Calédonie et l'Australie étaient des colonies pénitentiaires dans le Pacifique Sud. L’analyse du discours muséal des deux musées (Hyde Park Barracks à Sydney et le projet pour un musée du bagne à Nouméa se base sur la période pénitentiaire pour mettre en lumière les difficultés que l’on peut avoir à affronter son passé de violence. Même si ces deux pays ont une histoire différente, le but commun est d'accepter cette partie de leur généalogie. Après avoir été tabou, avoir des ancêtres criminels est maintenant une source de fierté; l'exil n'est plus considéré comme une expulsion de la patrie britannique ou française, mais plutôt comme une aventure de pionniers. Ceci entraîne un déni d'autres aspects

  15. New data on occurrence of Demodex flagellurus (Acari, Demodecidae) - rarely recorded parasite from the house mouse Mus musculus (Rodentia, Muridae).

    Science.gov (United States)

    Izdebska, Joanna N; Rolbiecki, Leszek

    2015-01-01

    Demodex flagellurus Bukva, 1985 is one of two known demodecid mites of the house mouse Mus musculus Linnaeus, 1758, in which it is observed in genital area. Skin fragments of 30 house mice from various regions of Poland (residential buildings in Gdynia and Gdańsk, rural region in Wielkopolska-Kujawska Lowland) were examined. The mites were noted in 25.0% of the mice, with mean intensity of 48.0 and intensity range of 2-103. D. flagellurus demonstrated the differentiated occurrence in host populations.

  16. Ocorrência de murcha bacteriana em helicônias e musácea ornamental no Distrito Federal

    OpenAIRE

    Zoccoli, Débora Maria; Tomita, Celso Katsuhiro; Uesugi,Carlos Hidemi

    2009-01-01

    Plantas de Heliconia spp. e Musa spp. apresentando murcha foram observadas em plantio comercial no Distrito Federal. Testes laboratoriais e de inoculação confirmaram como sendo a bactéria Ralstonia solanacearum biovar 1 raça 2 responsável pela doença. Este é o primeiro relato da presença da bactéria em helicônia e musácea ornamental na região. _______________________________________________________________________________ ABSTRACT Plants of Heliconia spp. and Musa spp. presenting wilt were...

  17. Dendrobium spectabile (Blume Miq in vitro culture and its acclimatization on Mus media with antimicrobial and alcoholic sugar supplementation

    Directory of Open Access Journals (Sweden)

    Untung Santoso

    2015-08-01

    Full Text Available Germination and development of orchid seed of Dendrobium spectabile through in vitro method has been done with good result and yielded many seeds. Different acclimatization approach was developed with sphagnum moss medium which supplemented with the same nutrition as MUS medium. Alcoholic sugar was supplemented to increase medium moisture and antimicrobial was added to minimalized contamination which can harm orchid seeds. Planlet adaptation ability to drought stress which resulted from in vitro culture can be improved using the new medium. The medium will increase the probability of seed survival also it will normalize seed development through the acclimatization process.

  18. High-resolution monitoring of stormwater quality in an urbanising catchment in the United Kingdom during the 2013/2014 winter storms

    Science.gov (United States)

    McGrane, S. J.; Hutchins, M. G.; Kjeldsen, T. R.; Miller, J. D.; Bussi, G.; Loewenthal, M.

    2015-12-01

    Urban areas are widely recognised as a key source of contaminants entering our freshwater systems, yet in spite of this, our understanding of stormwater quality dynamics remains limited. The development of in-situ, high-resolution monitoring equipment has revolutionised our capability to capture flow and water quality data at a sub-hourly resolution, enabling us to potentially enhance our understanding of hydrochemical variations from contrasting landscapes during storm events. During the winter of 2013/2014, the United Kingdom experienced a succession of intense storm events, where the south of the country experienced 200% of the average rainfall, resulting in widespread flooding across the Thames basin. We applied high-frequency (15 minute resolution) water quality monitoring across ten contrasting subcatchments (including rural, urban and mixed land-use catchments), seeking to classify the disparity in water quality conditions both within- and between events. Rural catchments increasingly behave like "urban" catchments as soils wet up and become increasingly responsive to subsequent events, however water quality response during the winter months remains limited. By contrast, increasingly urban catchments yield greater contaminant loads during events, and pre-event baseline chemistry highlights a resupply source in dense urban catchments. Wastewater treatment plants were shown to dominate baseline chemistry during low-flow events but also yield a considerable impact on stormwater outputs during peak-flow events, as hydraulic push results in the outflow of untreated solid wastes into the river system. Results are discussed in the context of water quality policy; urban growth scenarios and BMP for stormwater runoff in contrasting landscapes.

  19. Comparison of aerosol optical depth of UV-B Monitoring and Research Program (UVMRP), AERONET and MODIS over continental United States

    Institute of Scientific and Technical Information of China (English)

    Hongzhao TANG; Maosi CHEN; John DAVIS; Wei GAO

    2013-01-01

    The concern about the role of aerosols as to their effect in the Earth-Atmosphere system requires observation at multiple temporal and spatial scales.The Moderate Resolution Imaging Spectroradiameters (MODIS) is the main aerosol optical depth (AOD)monitoring satellite instrument,and its accuracy and uncertainty need to be validated against ground based measurements routinely.The comparison between two ground AOD measurement programs,the United States Department of Agriculture (USDA) Ultraviolet-B Monitoring and Research Program (UVMRP) and the Aerosol Robotic Network (AERONET) program,confirms the consistency between them.The intercomparison between the MODIS AOD,the AERONET AOD,and the UVMRP AOD suggests that the UVMRP AOD measurements are suited to be an alternative ground-based validation source for satellite AOD products.The experiments show that the spatial-temporal dependency between the MODIS AOD and the UVMRP AOD is positive in the sense that the MODIS AOD compare more favorably with the UVMRP AOD as the spatial and temporal intervals are increased.However,the analysis shows that the optimal spatial interval for all time windows is defined by an angular subtense of around 1° to 1.25°,while the optimal time window is around 423 to 483 minutes at most spatial intervals.The spatial-temporal approach around 1.25° & 423 minutes shows better agreement than the prevalent strategy of 0.25° & 60 minutes found in other similar investigations.Research Program (UVMRP),Aerosol Robotic Network (AERONET),Moderate Resolution Imaging Spectroradiameters (MODIS),validation,spatial-temporal approach

  20. The contribution of motor unit pairs to the correlation functions computed from surface myoelectric signals.

    Science.gov (United States)

    González-Cueto, José A; Erim, Zeynep

    2005-11-01

    The contribution of motor unit action potential trains (MUAPT) of distinct motor units (MU) to the crosscorrelation function between myoelectric signals (MES) recorded at the skin surface is studied. In specific, the significance of the correlation between the firing activity of concurrently active MUs (which results in cross-terms in the overall correlation function) is compared to the representation obtained using the contributions of single MUs at each recording site (auto-terms). A model for the generation of surface MUAPs is combined with the generation of MU firing statistics in order to obtain surface MUAPTs. MU firing statistics are simulated to incorporate MU synchronization levels reported in the literature. Alternatively, experimental firing statistics are fed to the model generating the MUAPTs. The contribution of individual MU pairs to the global myoelectric signal correlation function is assessed. Results indicate that the cross-terms from different MUs decrease steadily contributing very little to the overall correlation for record lengths as short as 30 s. Thus, the error expected when computing the crosscorrelation function between two channels of MES as the superposition of the auto-terms contributed by single MUs (i.e., ignoring the cross-terms from different MUs) is shown to be very small.

  1. Monitoramento de fungos anemófilos e de leveduras em unidade hospitalar Monitoring of airborne fungus and yeast species in a hospital unit

    Directory of Open Access Journals (Sweden)

    José Nelson Martins-Diniz

    2005-06-01

    Full Text Available OBJETIVO: Monitorar e caracterizar fungos anemófilos e leveduras de fontes bióticas e abióticas de uma unidade hospitalar. MÉTODOS: As coletas foram realizadas mensalmente e em dois períodos, do centro cirúrgico e unidades de terapia intensiva adulto e neonatal em hospital de Araraquara, Estado de São Paulo. Para coleta de fungos anemófilos foi utilizado amostrador tipo Andersen de simples estágio. A pesquisa de leveduras foi feita das mãos e de orofaringe de profissionais de saúde, bem como de superfícies de leitos e de maçanetas das áreas críticas. RESULTADOS: Foram recuperados do centro cirúrgico 32 gêneros de fungos anemófilos e 31 das unidades de terapia intensiva. Os gêneros mais freqüentemente isolados foram Cladophialophora spp., Fusarium spp., Penicillium spp., Chrysosporium spp. e Aspergillus spp. Durante o período de estudo, houve reforma e implantação de uma unidade dentro do hospital, que coincidiu com o aumento na contagem de colônias de Cladophialophora spp., Aspergillus spp. e Fusarium spp. Leveduras foram encontradas em 39,4% dos profissionais de saúde (16,7% das amostras dos espaços interdigitais, 12,1% do leito subungueal e 10,6% da orofaringe e, em 44% das amostras do mobiliário, com predomínio do gênero Candida (C. albicans, C. guilliermondii, C. parapsilosis e C. lusitaniae seguido por Trichosporon spp. CONCLUSÕES: Observou-se número relativamente elevado de fungos anemófilos (potencialmente patogênicos em áreas especiais e níveis expressivos de leveduras em fontes bióticas e abióticas. O monitoramento microbiológico ambiental deve ser realizado, principalmente em salas especiais com pacientes imunocomprometidos, sujeitos à exposição de patógenos do meio ambiente, assim como, advindos de profissionais de saúde.OBJECTIVE: To monitor and characterize airborne filamentous fungi and yeasts from abiotic and biotic sources within a hospital unit. METHODS: Collections were carried out on

  2. Post-Closure Inspection and Monitoring Report for Corrective Action Unit 110: Area 3 WMD U-3ax/bl Crater, Nevada Test Site, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    NSTec Environmental Restoration

    2006-08-01

    This Post-Closure Inspection and Monitoring Report (PCIMR) provides the results of inspections and monitoring for Corrective Action Unit (CAU) 110, Area 3 WMD [Waste Management Division] U-3ax/bl Crater. This PCIMR includes an analysis and summary of the site inspections, repairs and maintenance, meteorological information, and soil moisture monitoring data obtained at CAU 110, for the annual period July 2005 through June 2006. Site inspections of the cover were performed quarterly to identify any significant changes to the site requiring action. The overall condition of the cover, cover vegetation, perimeter fence, and UR warning signs was good. Settling was observed that exceeded the action level as specified in Section VILB.7 of the Hazardous Waste Permit Number NEV HW009 (Nevada Division of Environmental Protection, 2000). This permit states that cracks or settling greater than 15 centimeters (6 inches) deep that extend 1.0 meter (m) (3 feet [ft]) or more on the cover will be evaluated and repaired within 60 days of detection. Along the east edge of the cover (repaired previously in August 2003, December 2003, May 2004, October 2004), an area of settling was observed during the December 2005 inspection to again be above the action level, and required repair. This area and two other areas of settling on the cover that were first observed during the December 2005 inspection were repaired in February 2006. The semiannual subsidence surveys were done in September 2005 and March 2006. No significant subsidence was observed in the survey data. Monument 5 shows the greatest amount of subsidence (-0.015 m [-0.05 ft] compared to the baseline survey of 2000). This amount is negligible and near the resolution of the survey instruments; it does not indicate that subsidence is occurring on the cover. Soil moisture results obtained to date indicate that the CAU 110 cover is performing as expected. Time Domain Reflectometry (TDR) data indicated an increase in soil moisture (1

  3. Improvement of in-hospital telemetry monitoring in coronary care units: an intervention study for achieving optimal electrode placement and attachment, hygiene and delivery of critical information to patients.

    Science.gov (United States)

    Pettersen, Trond R; Fålun, Nina; Norekvål, Tone M

    2014-12-01

    In-hospital telemetry monitoring is important for diagnosis and treatment of patients at risk of developing life-threatening arrhythmias. It is widely used in critical and non-critical care wards. Nurses are responsible for correct electrode placement, thus ensuring optimal quality of the monitoring. The aims of this study were to determine whether a complex educational intervention improves (a) optimal electrode placement, (b) hygiene, and (c) delivery of critical information to patients (reason for monitoring, limitations in cellular phone use, and not to leave the ward without informing a member of staff). A prospective interventional study design was used, with data collection occurring over two six-week periods: before implementation of the intervention (n=201) and after the intervention (n=165). Standard abstraction forms were used to obtain data on patients' clinical characteristics, and 10 variables related to electrode placement and attachment, hygiene and delivery of critical information. At pre-intervention registration, 26% of the electrodes were misplaced. Twelve per cent of the patients received information about limiting their cellular phone use while monitored, 70% were informed of the purpose of monitoring, and 71% used a protective cover for their unit. Post-intervention, outcome measures for the three variables improved significantly: use of protective cover (p<0.001), information about the purpose of monitoring (p=0.005) and information about limitations in cellular phone use (p=0.003). Nonetheless, 23% of the electrodes were still misplaced. The study highlights the need for better, continued education for in-hospital telemetry monitoring in coronary care units, and other units that monitor patients with telemetry. © The European Society of Cardiology 2013.

  4. Dynamic changes of twitchlike responses to successive stimuli studied by decomposition of motor unit tetanic contractions in rat medial gastrocnemius.

    Science.gov (United States)

    Celichowski, Jan; Raikova, Rositsa; Aladjov, Hristo; Krutki, Piotr

    2014-12-15

    Unfused tetanic contractions evoked by trains of stimuli at variable interpulse intervals (IPIs) were recorded for 10 fast fatigable (FF), 10 fast resistant (FR), and 10 slow (S) motor units (MUs) and subsequently decomposed with a mathematical algorithm into trains of twitch-shape responses to successive stimuli. The mean stimulation frequencies were matched for each MU to evoke tetani of similar fusion degrees, whereas the variability range of IPIs was in each case 50-150% of the mean IPI. Force and time parameters of decomposed twitches were analyzed and related to the first response. Considerable variability of the analyzed twitch parameters was observed in each MU, although the largest range of variability occurred in slow MUs. In general, the decomposed twitch responses had longer duration and higher force than single-twitch contractions, although for nine FF and six FR MUs some of the decomposed responses were slightly weaker (but not faster) than the first twitches of these MUs. Comparison of the strongest decomposed twitch to the first decomposed twitch revealed ratios of forces up to 2.35, 3.33, and 6.89 for FF, FR, and S MUs and ratios of force-time areas up to 3.54, 4.67, and 14.26 for FF, FR, and S MUs, whereas for the contraction times the ratios of the longest decomposed twitch to the first twitch amounted to 2.46, 2.07, and 3.52 for FF, FR, and S MUs, respectively. The results indicate that contractile responses to successive action potentials are considerably variable, especially for slow MUs.

  5. Concurrent administration of the MMPI-2 and PAI in a sample of patients with epileptic or non-epileptic seizures: implications for an inpatient epilepsy monitoring unit.

    Science.gov (United States)

    Gale, Shawn D; Hill, Stacy W

    2012-10-01

    The Minnesota Multiphasic Personality Inventory-second edition (MMPI-2) and the Personality Assessment Inventory (PAI) are commonly used in the epilepsy monitoring unit (EMU) to evaluate personality characteristics and mood-related symptoms in those individuals being evaluated for epileptic seizures (ES) or psychogenic non-epileptic seizures (PNES). A direct comparison of these measures through concurrent administration to the same group has not been carried out. Both measures were administered to 40 patients (17 ES and 23 PNES). Logistic regression suggested the optimal predictive model for EMU discharge diagnosis included subscales from each measure, which outperformed either measure separately. Combining the conversion (SOM-C) and health concerns (SOM-H) subscales from the PAI and the hysteria subscale (Hy) from the MMPI-2 resulted in 85% overall classification accuracy, 86.7% sensitivity, and 82.4% specificity. Variability in the literature regarding the predictive utility of these measures may stem from the possibility that they measure different aspects of PNES. Copyright © 2012 Elsevier Inc. All rights reserved.

  6. Monitoring bioaccumulation and toxic effects of hexachlorobenzene using the polyurethane foam unit method in the microbial communities of the Fuhe River, Wuhan

    Institute of Scientific and Technical Information of China (English)

    LIU Ting; CHEN Zhu-lei; SHEN Yun-fen; GAN Lu; CAO Li; LV Zi-zhong

    2007-01-01

    Hexachlorobenzene (HCB) is a chlorinated aromatic hydrocarbon that was widely used for seed dressing in prevention of fungal growth on crops, and also as a component of fireworks, ammunition, and synthetic rubbers. Because of its resistance to degradation and mobility, HCB is widely distributed throughout the environment and is accumulated through food chains in different ecosystems. In this study, a preliminary investigation was carried out on the bioaccumulation and the toxic effects of HCB in the microbial (protozoan in particular) communities in the Fuhe River, Wuhan, a water body receiving industrial wastewaters containing HCB and other pollutants, using the standardized polyurethane foam units (PFU) method. Field samples were taken from eight stations established along the Fuhe River in January and August 2006. The concentration ratios of HCB in microbial communities and in water were 9.66-18.64, and the microbial communities accumulated 13.29-56.88 μg/L of HCB in January and 0.82-10.25 μg/L HCB in August. Correlation analysis showed a negative correlation between the HCB contents in the microbial assemblage, and the number of species and the diversity index of the protozoan communities. This study demonstrated the applicability of the PFU method in monitoring the effects of HCB on the level of microbial communities.

  7. Monitoring 2009 Forest Disturbance Across the Conterminous United States, Based on Near-Real Time and Historical MODIS 250 Meter NDVI Products

    Science.gov (United States)

    Spruce, J.; Hargrove, W. W.; Gasser, G.; Smoot, J. C.; Kuper, P.

    2009-01-01

    This case study shows the promise of computing current season forest disturbance detection products at regional to CONUS scales. Use of the eMODIS expedited product enabled a NRT CONUS forest disturbance detection product, a requirement for an eventual, operational forest threat EWS. The 2009 classification product from this study can be used to quantify the areal extent of forest disturbance across CONUS, although a quantitative accuracy assessment still needs to be completed. However, the results would not include disturbances that occurred after July 27, such as the Station Fire. While not shown here, the project also produced maximum NDVI products for the June 10-July 27 period of each year of the 2000-2009 time frame. These products could be applied to compute forest change products on an annual basis. GIS could then be used to assess disturbance persistence. Such follow-on work could lead to attribution of year in which a disturbance occurred. These products (e.g., Figures 6 and 7) may also be useful for assessing forest change associated with climate change, such as carbon losses from bark beetle-induced forest mortality in the Western United States. Other MODIS phenological products are being assessed for aiding forest monitoring needs of the EWS, including cumulative NDVI products (Figure 10).

  8. Post-Closure Inspection and Monitoring Report for Corrective Action Unit 417: Central Nevada Test Area Surface, Hot Creek Valley, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-01-01

    This report presents data collected during the annual post-closure site inspection conducted at the Central Nevada Test Area Surface Corrective Action Unit (CAU) 417 in May of 2008. The annual post-closure site inspection included inspections of the UC-1, UC-3, and UC-4 sites in accordance with the Post-Closure Monitoring Plan provided in the CAU 417 Closure Report (NNSA/NV 2001). The annual inspection conducted at the UC-1 Central Mud Pit (CMP) indicated that the site and soil cover were in good condition. Three new cracks or fractures were observed in the soil cover during the annual inspection and were immediately filled with bentonite chips. The vegetation on the soil cover was adequate, but showed signs of the area's ongoing drought. No issues were identified with the CMP fence, gate, or subsidence monuments. No issues were identified with the warning signs and monuments at the other two UC-1 locations. The annual subsidence survey was conducted at UC-1 CMP and UC-4 Mud Pit C in August 2008. The results of the subsidence surveys indicate that the covers are performing as expected, and no unusual subsidence was observed.

  9. Comparative genome mapping of the deer mouse (Peromyscus maniculatus reveals greater similarity to rat (Rattus norvegicus than to the lab mouse (Mus musculus

    Directory of Open Access Journals (Sweden)

    O'Neill Rachel J

    2008-02-01

    Full Text Available Abstract Background Deer mice (Peromyscus maniculatus and congeneric species are the most common North American mammals. They represent an emerging system for the genetic analyses of the physiological and behavioral bases of habitat adaptation. Phylogenetic evidence suggests a much more ancient divergence of Peromyscus from laboratory mice (Mus and rats (Rattus than that separating latter two. Nevertheless, early karyotypic analyses of the three groups suggest Peromyscus to be exhibit greater similarities with Rattus than with Mus. Results Comparative linkage mapping of an estimated 35% of the deer mouse genome was done with respect to the Rattus and Mus genomes. We particularly focused on regions that span synteny breakpoint regions between the rat and mouse genomes. The linkage analysis revealed the Peromyscus genome to have a higher degree of synteny and gene order conservation with the Rattus genome. Conclusion These data suggest that: 1. the Rattus and Peromyscus genomes more closely represent ancestral Muroid and rodent genomes than that of Mus. 2. the high level of genome rearrangement observed in Muroid rodents is especially pronounced in Mus. 3. evolution of genome organization can operate independently of more commonly assayed measures of genetic change (e.g. SNP frequency.

  10. 重症监护室手卫生效果监测与分析%Monitoring and analysis of hand hygiene in intensive care unit

    Institute of Scientific and Technical Information of China (English)

    冯书梅

    2013-01-01

    目的 监测重症监护室医务人员手卫生效果,并对相关因素进行分析,为今后改进手卫生工作提供依据.方法 对某院综合ICU、NSICU、NICU、CCU、RICU的医务人员手卫生后,进行诊疗活动或其他无菌操作前进行采样.根据GB 15982-1995《医院消毒卫生标准》要求医务人员手卫生的标准,统计不同医务人员、不同手卫生方法和不同重症监护室手卫生效果监测结果.结果 监护护士的手卫生监测合格率为92.42%,其次是医生和实习护士,合格率最低的是医技人员;快速手消毒剂效果较洗手液流动水洗手效果更好;手卫生效果监测合格率与工作量有密切关系.结论 医院感染管理者将医技人员作为医院感染知识培训和控制医院感染监测、考核的重点人群;监护室快速手消毒剂的广泛应用和合理的人员配备是落实手卫生的重要保证.%OBJECTIVE To monitor the hand hygiene of medical personnel in intensive care unit, and analyze the relative factors in order to provide the basis for improving hand hygiene's work. METHODS Medical personnel were took samples after hand hygiene and before clinical activities or other sterile operations in the ICU, NSICU, NICU, CCU and RICU of our hospital. According to GB15982-1995 "hospital disinfectant sanitation standard", we analyzed the monitoring hand hygiene's results from different medical staffs, different hand hygiene methods and different intensive care units. RESULTS The qualified rate of hand hygiene was 92.42% in intensive care nurse, followed by the doctor and intern nurse, that of the technician was the lowest; The effect of hands disinfectant was better than flowing water; The qualified rate of hand hygiene had a close relationship with workload. CONCLUSION The hospital infection managers should put emphasis on the technicians in training the knowledge of hospital infection, monitoring and controlling hospital infection; The extensive use

  11. ORALLY LACTATE CALCIUM AND SWIMMING DECREASE OSTEOCLAST AND INCREASE OSTEOBLAST IN RADIAL PERIMENOPAUSAL MICE (MUS MUSCULUS BONE

    Directory of Open Access Journals (Sweden)

    Muliani **

    2013-04-01

    Full Text Available Calcium and moderate intensity swimming exercise can increase bone density. The aim of this research is to see the effect of orally calcium consumption and swimming activity to decrease osteoclast and increase osteoblast in radial perimenopausal mice (Mus musculus bone. Pretest and pos#est control group design was used in this research. Research subject used 15-16 aged mice (Mus musculus which divided into 4 groups (each group consisted of 13 mice, that was control, lactate calcium, swimming and lactate calcium and swimming. Treatment was given 90 days. This study showed a significant difference of the mean of the pos#est osteoblast between control and experimental groups (P<0.05. There was no significant difference between lactate calcium and swimming groups (P>0.05. Enhancement of osteoblast mean in combination group was greater than the other experimental groups. There was a significant difference of the mean of the pos#est  osteoclast between control and experimental groups (P<0.05, without significant difference between lactate calcium,   swimming groups and combination of lactate calcium and swimming group (P>0.05.  Conclusion: either lactate calcium or swimming decreases osteoclast and increases osteoblast of the mice but the osteoblast enhancement will be bigger when they are given together at once

  12. Mx1 causes resistance against influenza A viruses in the Mus spretus-derived inbred mouse strain SPRET/Ei.

    Science.gov (United States)

    Vanlaere, Ineke; Vanderrijst, Ananza; Guénet, Jean-Louis; De Filette, Marina; Libert, Claude

    2008-04-01

    Inbred SPRET/Ei mice, derived from Mus spretus, were found to be extremely resistant to infection with a mouse adapted influenza A virus. The resistance was strongly linked to distal chromosome 16, where the interferon-inducible Mx1 gene is located. This gene encodes for the Mx1 protein which stimulates innate immunity to Orthomyxoviruses. The Mx1 gene is defective in most inbred mouse strains, but PCR revealed that SPRET/Ei carries a functional allele. The Mx1 proteins of M. spretus and A2G, the other major resistant strain derived from Mus musculus, share 95.7% identity. We were interested whether the sequence variations between the two Mx1 alleles have functional significance. To address this, we used congenic mouse strains containing the Mx1 gene from M. spretus or A2G in a C57BL/6 background. Using a highly pathogenic influenza virus strain, we found that the B6.spretus-Mx1 congenic mice were better protected against infection than the B6.A2G-Mx1 mice. This effect may be due to different Mx1 induction levels, as was shown by RT-PCR and Western blot. We conclude that SPRET/Ei is a novel Mx1-positive inbred strain useful to study the biology of Mx1.

  13. [Relationship between characteristics of sexual behavior and male sperm competitive ability in taxa of superspecies complex Mus musculus sensu lato].

    Science.gov (United States)

    Ambaryan, A B; Maltzev, A N; Kotenkova, E V

    2015-01-01

    Some physiological parameters that determine quality of male sperm (its concentration, spermatozoa morphology) and testicle size vary in integrity, i.e. the bigger are testicles the higher is sperm quality. Therefore, the estimate of testicles relative mass is often used as a characteristic of sperm competitive ability when comparing phylogenetically close mammal species. In house mice belonging to the superspecies complex Mus musculus s.l., testicles relative mass is greater in exoanthropic species than in synanthropic ones. It is shown in our study that this pattern is apparent also at the intraspecies level since testicles mass index, sperm concentration, and percentage of morphologically normal spermatozoa in subspecies Mus musculus wagneri, which is facultatively synanthropic, are higher compared with synanthropic subspecies M m. musculus. An analysis of sexual behavior of the three forms (namely, exoanthropic species M. spicilegus and two subspecies mentioned above) indicates that in M. spicilegus both sexual behavior efficiency and ejaculation rate during coupling were higher as compared with other two subspecies. Based on the analysis of life pattern, reproduction systems, and group spatial-ethological structure, the hypotheses are formulated that explain the maintenance of selection directed to increase of sperm competitive ability in exoanthropic house mice species.

  14. Retracing the restoration history of Viennese paintings in the Musée Napoléon (1809-1815

    Directory of Open Access Journals (Sweden)

    Natalia Gustavson

    2012-04-01

    Full Text Available En 1809, une multitude de tableaux issus de la galerie impériale de Vienne fut saisie au château du Belvédère et transportée à Paris, au Musée Napoléon. La plupart de ces objets d´art ont été restitués en 1815. Jusqu’à présent, on ignorait dans quelles mesures ces tableaux avaient été traités par des restaurateurs parisiens. Cet article a pour but d´étudier ces interventions françaises en se reportant à un groupe de tableaux de la collection actuelle du Kunsthistorisches Museum à Vienne.In 1809, a multitude of paintings belonging to the Austrian imperial collection was seized in Belvedere Palace in Vienna and brought to the Parisian Musée Napoléon. Those artworks have mainly been returned in 1815. Up to now, it remained unclear to what extent these paintings had been subjected to restoration treatments while in France. The following paper addresses the French treatment of a group of paintings today belonging to the Kunsthistorisches Museum in Vienna.  

  15. A MusD retrotransposon insertion in the mouse Slc6a5 gene causes alterations in neuromuscular junction maturation and behavioral phenotypes.

    Directory of Open Access Journals (Sweden)

    Laurent P Bogdanik

    Full Text Available Glycine is the major inhibitory neurotransmitter in the spinal cord and some brain regions. The presynaptic glycine transporter, GlyT2, is required for sustained glycinergic transmission through presynaptic reuptake and recycling of glycine. Mutations in SLC6A5, encoding GlyT2, cause hereditary hyperekplexia in humans, and similar phenotypes in knock-out mice, and variants are associated with schizophrenia. We identified a spontaneous mutation in mouse Slc6a5, caused by a MusD retrotransposon insertion. The GlyT2 protein is undetectable in homozygous mutants, indicating a null allele. Homozygous mutant mice are normal at birth, but develop handling-induced spasms at five days of age, and only survive for two weeks, but allow the study of early activity-regulated developmental processes. At the neuromuscular junction, synapse elimination and the switch from embryonic to adult acetylcholine receptor subunits are hastened, consistent with a presumed increase in motor neuron activity, and transcription of acetylcholine receptors is elevated. Heterozygous mice, which show no reduction in lifespan but nonetheless have reduced levels of GlyT2, have a normal thermal sensitivity with the hot-plate test, but differences in repetitive grooming and decreased sleep time with home-cage monitoring. Open-field and elevated plus-maze tests did not detect anxiety-like behaviors; however, the latter showed a hyperactivity phenotype. Importantly, grooming and hyperactivity are observed in mouse schizophrenia models. Thus, mutations in Slc6a5 show changes in neuromuscular junction development as homozygotes, and behavioral phenotypes as heterozygotes, indicating their usefulness for studies related to glycinergic dysfunction.

  16. Monitoring Sub-Saharan African physician migration and recruitment post-adoption of the WHO code of practice: temporal and geographic patterns in the United States.

    Science.gov (United States)

    Tankwanchi, Akhenaten Benjamin Siankam; Vermund, Sten H; Perkins, Douglas D

    2015-01-01

    Data monitoring is a key recommendation of the WHO Global Code of Practice on the International Recruitment of Health Personnel, a global framework adopted in May 2010 to address health workforce retention in resource-limited countries and the ethics of international migration. Using data on African-born and African-educated physicians in the 2013 American Medical Association Physician Masterfile (AMA Masterfile), we monitored Sub-Saharan African (SSA) physician recruitment into the physician workforce of the United States (US) post-adoption of the WHO Code of Practice. From the observed data, we projected to 2015 with linear regression, and we mapped migrant physicians' locations using GPS Visualizer and ArcGIS. The 2013 AMA Masterfile identified 11,787 active SSA-origin physicians, representing barely 1.3% (11,787/940,456) of the 2013 US physician workforce, but exceeding the total number of physicians reported by WHO in 34 SSA countries (N = 11,519). We estimated that 15.7% (1,849/11,787) entered the US physician workforce after the Code of Practice was adopted. Compared to pre-Code estimates from 2002 (N = 7,830) and 2010 (N = 9,938), the annual admission rate of SSA émigrés into the US physician workforce is increasing. This increase is due in large part to the growing number of SSA-born physicians attending medical schools outside SSA, representing a trend towards younger migrants. Projection estimates suggest that there will be 12,846 SSA migrant physicians in the US physician workforce in 2015, and over 2,900 of them will be post-Code recruits. Most SSA migrant physicians are locating to large urban US areas where physician densities are already the highest. The Code of Practice has not slowed the SSA-to-US physician migration. To stem the physician "brain drain", it is essential to incentivize professional practice in SSA and diminish the appeal of US migration with bolder interventions targeting primarily early-career (age ≤ 35) SSA physicians.

  17. Use of Current 2010 Forest Disturbance Monitoring Products for the Conterminous United States in Aiding a National Forest Threat Early Warning System

    Science.gov (United States)

    Spruce, Joseph P.; Hargrove, William; Gasser, J.; Smoot, J.; Kuper, P.

    2010-01-01

    This presentation discusses contributions of near real time (NRT) MODIS forest disturbance detection products for the conterminous United States to an emerging national forest threat early warning system (EWS). The latter is being developed by the USDA Forest Service s Eastern and Western Environmental Threat Centers with help from NASA Stennis Space Center and the Oak Ridge National Laboratory. Building off work done in 2009, this national and regional forest disturbance detection and viewing capability of the EWS employs NRT MODIS NDVI data from the USGS eMODIS group and historical NDVI data from standard MOD13 products. Disturbance detection products are being computed for 24 day composites that are refreshed every 8 days. Products for 2010 include 42 dates of the 24 day composites. For each compositing date, we computed % change in forest maximum NDVI products for 2010 with respect to each of three historical baselines of 2009, 2007-2009, and 2003-2009,. The three baselines enable one to view potential current, recent, and longer term forest disturbances. A rainbow color table was applied to each forest change product so that potential disturbances (NDVI drops) were identified in hot color tones and growth (NDVI gains) in cold color tones. Example products were provided to end-users responsible for forest health monitoring at the Federal and State levels. Large patches of potential forest disturbances were validated based on comparisons with available reference data, including Landsat and field survey data. Products were posted on two internet mapping systems for US Forest Service internal and collaborator use. MODIS forest disturbance detection products were computed and posted for use in as little as 1 day after the last input date of the compositing period. Such products were useful for aiding aerial disturbance detection surveys and for assessing disturbance persistence on both inter- and intra-annual scales. Multiple 2010 forest disturbance events were

  18. iTRAQ analysis of hepatic proteins in free-living Mus spretus mice to assess the contamination status of areas surrounding Doñana National Park (SW Spain)

    Energy Technology Data Exchange (ETDEWEB)

    Abril, Nieves; Chicano-Gálvez, Eduardo; Michán, Carmen; Pueyo, Carmen; López-Barea, Juan, E-mail: bb1lobaj@uco.es

    2015-08-01

    This work aims to develop and integrate new -omics tools that would be applicable to different ecosystem types for a technological updating of environmental evaluations. We used a 2nd-generation (iTRAQ-8plex) proteomic approach to identify/quantify proteins differentially expressed in the liver of free-living Mus spretus mice from Doñana National Park or its proximities. Mass spectrometry was performed in an LTQ Orbitrap system for iTRAQ reporter ion quantitation and protein identification using a Mus musculus database as reference. A prior IEF step improved the separation of the complex peptide mixture. Over 2000 identified proteins were altered, of which 118 changed by ≥ 2.5-fold in mice from at least two problem sites. Part of the results obtained with the iTRAQ analysis was confirmed by Western blot. Over 75% of the 118 proteins were upregulated in animals captured at polluted sites and only 16 proteins were downregulated. Upregulated proteins were involved in stress response; cell proliferation and apoptosis; signal transduction; metastasis or tumour suppression; xenobiotic export or vesicular trafficking; and metabolism. The downregulated proteins, all potentially harmful, were classified as oncoproteins and proteins favouring genome instability. The iTRAQ results presented here demonstrated that the survival of hepatic cells is compromised in animals living at polluted sites, which showed deep alterations in metabolism and the signalling pathways. The identified proteins may be useful as biomarkers of environmental pollution and provide insight about the metabolic pathways and/or physiological processes affected by pollutants in DNP and its surrounding areas. - Highlights: • iTRAQ quantitation was used for the first time to monitor a wildlife reserve • Over 2,000 proteins with altered expression were identified in problem Doñana sites • Of them, 118 changed over 2.5-fold in, at least, two problem sites • Upregulation of protective proteins

  19. Disodium cromoglycate inhibits S mu-->S epsilon deletional switch recombination and IgE synthesis in human B cells

    Science.gov (United States)

    1994-01-01

    IgE synthesis requires interleukin 4 (IL-4) and a T-B cell interaction that involves the B cell antigen CD40 and its ligand expressed on activated T cells. IL-4 induces epsilon germline transcription whereas ligation of CD40 results in deletional S mu-->S epsilon switch recombination, expression of mature epsilon transcripts, and IgE synthesis and secretion. We demonstrate that disodium cromoglycate (DSCG), a drug commonly used for the prophylactic treatment of allergic disease, inhibits T cell-driven IgE synthesis by human B cells at concentrations readily achievable in the course of inhaled therapy for asthma. Inhibition of IgE synthesis by DSCG was not the result of drug toxicity because DSCG did not affect the viability of T and B cells or their proliferation to mitogens. DSCG did not interfere with CD40 ligand expression by T cells but clearly targeted the B cells because it inhibited IgE synthesis induced by anti-CD40 and IL-4 in populations of highly purified B cells. DSCG had no effect on the induction of epsilon germline transcripts by IL-4 but strongly inhibited CD40 mediated S mu-->S epsilon deletional switch recombination in IL-4- treated B cells as assayed by nested primer PCR. The effect of DSCG was not specific for CD40-mediated induction of IgE isotype switching because DSCG inhibited IgE synthesis as well as S mu-->S epsilon deletional switch recombination induced by hydrocortisone and IL-4 in B cells. Moreover, the effect of DSCG was not specific for IgE isotype switching because DSCG inhibited the synthesis of IgG4 by B cells sorted for lack of surface expression of IgG4 and stimulated with anti- CD40 and IL-4. DSCG caused only minimal inhibition (< 15%) of spontaneous IgE synthesis by lymphocytes from patients with the hyper- IgE syndrome and did not affect pokeweed mitogen-induced IgG and IgA synthesis by lymphocytes suggesting that it has little effect on B cells that have already undergone isotype switching. These results indicate that DSCG

  20. Monitoring Groundwater Variations from Satellite Gravimetry and Hydrological Models: A Comparison with in-situ Measurements in the Mid-Atlantic Region of the United States

    Directory of Open Access Journals (Sweden)

    Ruya Xiao

    2015-01-01

    Full Text Available Aimed at mapping time variations in the Earth’s gravity field, the Gravity Recovery and Climate Experiment (GRACE satellite mission is applicable to access terrestrial water storage (TWS, which mainly includes groundwater, soil moisture (SM, and snow. In this study, SM and accumulated snow water equivalent (SWE are simulated by the Global Land Data Assimilation System (GLDAS land surface models (LSMs and then used to isolate groundwater anomalies from GRACE-derived TWS in Pennsylvania and New York States of the Mid-Atlantic region of the United States. The monitoring well water-level records from the U.S. Geological Survey Ground-Water Climate Response Network from January 2005 to December 2011 are used for validation. The groundwater results from different combinations of GRACE products (from three institutions, CSR, GFZ and JPL and GLDAS LSMs (CLM, NOAH and VIC are compared and evaluated with in-situ measurements. The intercomparison analysis shows that the solution obtained through removing averaged simulated SM and SWE of the three LSMs from the averaged GRACE-derived TWS of the three centers would be the most robust to reduce the noises, and increase the confidence consequently. Although discrepancy exists, the GRACE-GLDAS estimated groundwater variations generally agree with in-situ observations. For monthly scales, their correlation coefficient reaches 0.70 at 95% confidence level with the RMSE of the differences of 2.6 cm. Two-tailed Mann-Kendall trend test results show that there is no significant groundwater gain or loss in this region over the study period. The GRACE time-variable field solutions and GLDAS simulations provide precise and reliable data sets in illustrating the regional groundwater storage variations, and the application will be meaningful and invaluable when applied to the data-poor regions.

  1. [A study of epilepsy according to the age at onset and monitored for 3 years in a regional reference paediatric neurology unit].

    Science.gov (United States)

    Ochoa-Gómez, Laura; López-Pisón, Javier; Lapresta Moros, Carlos; Fuertes Rodrigo, Cristina; Fernando Martínez, Ruth; Samper-Villagrasa, Pilar; Monge-Galindo, Lorena; Peña-Segura, José Luis; García-Jiménez, María Concepción

    2017-01-01

    A study of epilepsy, according to the age at onset of the crisis and its causes, monitored by a Paediatric Neurology Unit over a period of three years. Historical cohorts study was conducted by reviewing the Paediatric Neurology medical records data base of epileptic children followed-up from 1 January 2008 to 31 December 2010. A total of 4,595 children were attended during the study period. The diagnosis of epilepsy was established in 605 (13.17%): 277 (45.79%) symptomatic, 156 (25.79%) idiopathic, and 172 (28.43%) with cryptogenic epilepsy. Absence epilepsy and benign childhood epilepsy with centro-temporal spikes are the idiopathic epileptic syndromes most prevalent, and the most prevalent symptomatic epilepsies are prenatal encephalopathies. More than one-quarter (26.12%) of epilepsies began in the first year of life, and 67.72% were symptomatic. Refractory epilepsy was observed in 25.29%, 42.46% with cognitive impairment, 26.45% with motor involvement, and 9.92% with an autism spectrum disorder, being more frequent at an earlier age of onset. The absence of a universally accepted classification of epileptic syndromes makes tasks like this difficult, starting with the terminology. A useful classification would be aetiological, with two groups: a large group with established aetiology, or very likely genetic syndromes, and another with no established cause. The age of onset of epilepsy in each aetiological group helps in the prognosis, which is worsened by refractoriness and associated neurodevelopmental disorders, and are generally worse at an earlier onset and in certain aetiologies. Copyright © 2015 Asociación Española de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

  2. Design and implementation of the National Water-Quality Assessment Program: a United States example: understanding the limitations of using compliance-monitoring data to assess the water quality of a large river basin

    Science.gov (United States)

    Wangsness, David J.

    1997-01-01

    In the 1980s it was determined that existing ambient and compliance-monitoring data could not satisfactorily evaluate the results of hundreds of billions of dollars spent for water-pollution abatement in the United States. At the request of the US Congress, a new programme, the National Water-Quality Assessment, was designed and implemented by government agency, the US Geological Survey (USGS). The Assessment has reported status and trends in surface- and ground-water quality at national, regional, and local scales since 1991. The legislative basis for US monitoring and data-sharing policies are identified as well as the successive phases of the design and implementation of the USGS Assessment. Application to the Danube Basin is suggested. Much of the water-quality monitoring conducted in the United States is designed to comply with Federal and State laws mandated primarily by the Clean Water Act of 1987 and the Safe Drinking Water Act of 1986. Monitoring programs generally focus on rivers upstream and downstream of point-source discharges and at water-supply intakes. Few data are available for aquifer systems, and chemical analyses are often limited to those constituents required by law. In most cases, the majority of the available chemical and streamflow data have provided the information necessary to meet the objectives of the compliance-monitoring programs, but do not necessarily provide the information requires for basin-wide assessments of the water quality at the local, regional, or national scale.

  3. Identifying management units in non-endangered species: the example of the sloth Bradypus variegatus Schinz, 1825.

    Science.gov (United States)

    Moraes-Barros, N; Miyaki, C Y; Morgante, J S

    2007-12-01

    In this study we propose the analysis of genetic diversity of the common three-toed sloth, Bradypus variegatus, in an attempt to understand population structure, identify divergent intraspecific units, and contribute to the knowledge of biodiversity in the neotropical forests. We analyzed a 387 bp segment of the mitochondrial DNA control region in 28 individuals distributed in different localities of both Atlantic and Amazon forests. Our results demonstrated that the genetic diversity of B. variegatus is distributed in six management units, MUs. The observed MUs encompass six phylogenetic lineages and represent respectively north and south regions of Atlantic forest, three regions within the Amazon forest, and a transition region between these two biomes. Considering the fact that these MUs are concordant with phylogroups and endemism areas already described for other vertebrate species, we can say that the study of B. variegatus, a widely distributed and not endangered species, can help to identify areas for conservation biology purposes in neotropical rain forests.

  4. PENGARUH DOSIS DAN LAMA PERLAKUAN EKSTRAK DAUN KALIANDRA MERAH (Calliandra calothyrsus Meissn. TERHADAP STRUKTUR HISTOLOGI GINJAL MENCIT (Mus musculus L.

    Directory of Open Access Journals (Sweden)

    Nur Assiam

    2014-09-01

    Full Text Available This research aims to determine the effect of red calliandra (Calliandra calothyrsusMeissn. leaf extrac on the histological structure of the kidney of mice (Mus musculus L..Treatment was administered orally with varying doses. This research used a CompletelyRandomized Design in factorial pattern of two factors, doses (0 or control, 2, 4, and 6 mg/kgBW and length of treatment (7, 14, and 21 days, so there are 12 combination groups with 3replications of each. Organ was collected on days 8, 15, and 22 to observe histologicalstructure of the kidney. Renal histological observation of edema, Bowman’s spaceconstriction, and protein deposition, showed no correlation between both factors, but a veryreal correlation occurs in the damage of fatty degeneration, hemorrhage, and nucleuspyknotic. Histological observation of glomerular congestion and infiltration of inflammatorycells did not show any correlation between dose and duration of treatment.Keywords: red calliandra, histopathology of kidney, male mice

  5. Retracing the restoration history of Viennese paintings in the Musée Napoléon (1809-1815)

    OpenAIRE

    Natalia Gustavson

    2012-01-01

    En 1809, une multitude de tableaux issus de la galerie impériale de Vienne fut saisie au château du Belvédère et transportée à Paris, au Musée Napoléon. La plupart de ces objets d´art ont été restitués en 1815. Jusqu’à présent, on ignorait dans quelles mesures ces tableaux avaient été traités par des restaurateurs parisiens. Cet article a pour but d´étudier ces interventions françaises en se reportant à un groupe de tableaux de la collection actuelle du Kunsthistorisches Museum à Vienne.In 18...

  6. Pengaruh VCO terhadap hitung jenis leukosit, kadar glukosa dan kreatinin darah Mus musculus Balb/c hiperglikemi dan tersensitisasi ovalbumin

    Directory of Open Access Journals (Sweden)

    NOOR SOESANTI HANDAJANI

    2009-05-01

    Full Text Available Handajani NS, Dharmawan R. 2009. Pengaruh VCO terhadap hitung jenis leukosit, kadar glukosa dan kreatinin darah Mus musculus Balb/c hiperglikemi dan tersensitisasi ovalbumin. Bioteknologi 6: 1-10. Obat-obatan kimia dan insulin dapat menurunkan kadar glukosa darah pada pasien dengan efek samping hiperglikemi makro vaskular. Diabetes dan insiden alergi dipengaruhi kualitas dan kuantitas leukosit. Asam laurat dalam VCO dilaporkan menurunkan tingkat glukosa darah pada kejadian diabetes dan beberapa insiden alergi. Tujuan penelitian ini adalah mengetahui pengaruh VCO pada tingkat glukosa darah, diferensial leukosit dan kadar kreatinin pada mencit hiperglikemi dan normoglicemic tersensitisasi ovalbumin. Empat puluh lima (45 mencit Mus musculus Balb/c jantan dengan berat rata-rata 35 g dibagi menjadi 9 kelompok dengan 5 ulangan, yaitu 4 kelompok non aloksan dan 5 kelompok hiperglikemi yang diinduksi aloksan, Pada hari ke-22 sampai ke-36, mereka disensitisasi dengan ovalbumin sebagai penyebab alergi. Sampel darah diperoleh dari vena orbital menggunakan heparin sebagai anti koagulan, kadar glukosa darah diukur dengan metode GOD sebanyak 6 kali, pada hari ke-1, 4, 18, 22, 32 dan 37, kemudian diuji dengan ANAVA yang diikuti oleh DMRT 0,05 untk mengetahui tingkat perbedaan antar perlakuan. Pada hari ke-37, diferensial leukosit dan tingkat kreatinin darah ditentukan, lalu dibandingkan dengan nilai normal. Hasil penelitian menunjukkan bahwa dalam hitungan diferensial leukosit mencit hiperglikemi, persentase neutrofil jauh lebih rendah daripada nilai normal (3.22%, dan persentase limfosit jauh lebih tinggi daripada nilai normal (94.54%. Konsumsi 0.003 mL/35 g VCO lebih dari 18 hari menurunkan kadar glukosa darah pada mencit hiperglikemi, menurunkan persentase basophile pada mencit tersensitisasi ovalbumin, normalisasi persentase neutrophile tidak meningkatkan tingkat kreatinin darah.

  7. Monitoring of Power Station Steels Using Electromagnetic Sensors

    OpenAIRE

    Karimian, Noushin

    2014-01-01

    With the world’s aging power generation network, especially in Europe and the United States, life-extension of steel plant components is increasingly a critical issue, as components are exposed to high temperatures and pressures during their lifetime, potentially resulting in carbide coarsening, making them prone to creep cavitation, possibly leading to component failure. Therefore, in order to evaluate the likelihood of component failure, non-destructive testing and evaluation procedures mus...

  8. Effect of wheat (Triticum aestivum L.) seed color and hardness genes on the consumption preference of the house mouse (Mus musculus L.)

    Science.gov (United States)

    Background: Wheat (Triticum aestivum L.) grain is a staple food and provides necessary nutrients for human health and nutrition. Yet, flavor differences among wheat varieties are not well understood. Grain flavor and consumption preference can be examined using the house mouse (Mus musculus L.) as a...

  9. RCRA Post-Closure Monitoring and Inspection Report for CAU 91: Area 3 U-3fi Waste Unit, Nevada Test Site, Nevada, for the Period October 1999-October 2000

    Energy Technology Data Exchange (ETDEWEB)

    D. F. Emer

    2001-02-01

    This annual Neutron Soil Moisture Monitoring report provides an analysis and summary for site inspections, meteorological information, and neutron soil moisture monitoring data obtained at the U-3fi Resource Conservation and Recovery Act Unit, located in Area 3 of the Nevada Test Site, Nye County, Nevada, during the October 1999 to October 2000 period. Inspections of the U-3fi Resource Conservation and Recovery Act Unit are conducted to determine and document the physical condition of the concrete pad, facilities, and any unusual conditions that could impact the proper operation of the waste unit closure. The objective of the neutron-logging program is to monitor the soil moisture conditions along the 128-meter (m) (420-feet [ft]) ER3-3 monitoring well and detect changes that maybe indicative of moisture movement in the regulated interval extending between 73 to 82 m (240 to 270 ft) or to detect changes that maybe indicative of subsidence within the disposal unit itself. Physical inspections of the closure were completed in March and September 2000 and indicated that the site is in good condition with no significant findings noted. The directional survey which is required to be completed every five years was run in the ER3-3 casing to determine if subsidence was occurring in the U-3fi emplacement borehole. Small changes were noted which are attributed to initial settling of the sand pack stemming. No evidence of subsidence within the emplacement borehole was observed. The subsidence survey for the October 1999 to October 2000 monitoring period indicated an increase in elevation of 0.244 centimeters (cm) (0.008 ft) compared to the previous year, July 1999. All changes in subsidence survey data taken to date are so small as to be at the survey instrument resolution level and it is not clear if they represent subsidence or measurement error. There is no clear evidence for any subsidence of the monument. Soil moisture monitoring results indicate dry stable conditions

  10. Impact of different leaf velocities and dose rates on the number of monitor units and the dose-volume-histograms using intensity modulated radiotherapy with sliding-window technique

    Directory of Open Access Journals (Sweden)

    Hess Clemens F

    2008-09-01

    Full Text Available Abstract Background Intensity modulated radiotherapy (IMRT using sliding window technique utilises a leaf sequencing algorithm, which takes some control system limitations like dose rates (DR and velocity of the leafs (LV into account. The effect of altering these limitations on the number of monitor units and radiation dose to the organs at risk (OAR were analysed. Methods IMRT plans for different LVs from 1.0 cm/sec to 10.0 cm/sec and different DRs from 100 MU/min to 600 MU/min for two patients with prostate cancer and two patients with squamous cell cancer of the scalp (SCCscalp were calculated using the same "optimal fluence map". For each field the number of monitor units, the dose volume histograms and the differences in the "actual fluence maps" of the fields were analysed. Results With increase of the DR and decrease of the LV the number of monitor units increased and consequentially the radiation dose given to the OAR. In particular the serial OARs of patients with SCCscalp, which are located outside the end position of the leafs and inside the open field, received an additional dose of a higher DR and lower LV is used. Conclusion For best protection of organs at risk, a low DR and high LV should be applied. But the consequence of a low DR is both a long treatment time and also that a LV of higher than 3.0 cm/sec is mechanically not applicable. Our recommendation for an optimisation of the discussed parameters is a leaf velocity of 2.5 cm/sec and a dose rate of 300–400 MU/min (prostate cancer and 100–200 MU/min (SCCscalp for best protection of organs at risk, short treatment time and number of monitor units.

  11. Comparison of the ESTRO formalism for monitor unit calculation with a Clarkson based algorithm of a treatment planning system and a traditional "full-scatter" methodology.

    Science.gov (United States)

    Pirotta, Martin; Aquilina, Dorothy; Bhikha, Tilluck; Georg, Dietmar

    2005-01-01

    The ESTRO formalism for monitor unit (MU) calculations was evaluated and implemented to replace a previous methodology based on dosimetric data measured in a full-scatter phantom. This traditional method relies on data normalised at the depth of dose maximum (Zm), as well as on the utilisation of the BJR 25 table for the conversion of rectangular fields into equivalent square fields. The treatment planning system (TPS) was subsequently updated to reflect the new beam data normalised at a depth ZR of 10 cm. Comparisons were then carried out between the ESTRO formalism, the Clarkson-based dose calculation algorithm on the TPS (with beam data normalised at Zm and ZR), and the traditional "full-scatter" methodology. All methodologies, except for the "full-scatter" methodology, separated head-scatter from phantom-scatter effects and none of the methodologies; except for the ESTRO formalism, utilised wedge depth dose information for calculations. The accuracy of MU calculations was verified against measurements in a homogeneous phantom for square and rectangular open and wedged fields, as well as blocked open and wedged fields, at 5, 10, and 20 cm depths, under fixed SSD and isocentric geometries for 6 and 10 MV. Overall, the ESTRO Formalism showed the most accurate performance, with the root mean square (RMS) error with respect to measurements remaining below 1% even for the most complex beam set-ups investigated. The RMS error for the TPS deteriorated with the introduction of a wedge, with a worse RMS error for the beam data normalised at Zm (4% at 6 MV and 1.6% at 10 MV) than at ZR (1.-9% at 6 MV and 1.1% at 10 MV). The further addition of blocking had only a marginal impact on the accuracy of this methodology. The "full-scatter" methodology showed a loss in accuracy for calculations involving either wedges or blocking, and performed worst for blocked wedged fields (RMS errors of 7.1% at 6 MV and 5% at 10 MV). The origins of these discrepancies were quantified and the

  12. A detection-level hazardous waste ground-water monitoring compliance plan for the 200 areas low-level burial grounds and retrievable storage units

    Energy Technology Data Exchange (ETDEWEB)

    1987-02-01

    This plan defines the actions needed to achieve detection-level monitoring compliance at the Hanford Site 200 Areas Low-Level Burial Grounds (LLBG) in accordance with the Resource Conservation and Recovery Act (RCRA). Compliance will be achieved through characterization of the hydrogeology and monitoring of the ground water beneath the LLBG located in the Hanford Site 200 Areas. 13 refs., 20 figs.

  13. Effects of age at cordotomy and subsequent exercise on contraction times of motor units in the cat.

    Science.gov (United States)

    Smith, L A; Eldred, E; Edgerton, V R

    1993-12-01

    The contraction times (CTs) of functionally isolated motor units (MUs) in the soleus (SOL) and medial gastrocnemius (MG) muscles were determined in cats that had been spinalized at ages 2 (n = 15) or 12 (n = 9) wk and then either subjected to exercise on a treadmill or simply given manipulative care of the hindlimbs. The MUs were tested approximately 12 wk after the low-thoracic cordotomy, and comparisons were made with data from control animals. The CT of 50.9 ms obtained for SOL units (n = 163) in the spinal cats was 22% shorter than the mean of 65.0 ms for MUs (n = 57) from control cats (n = 4). Contrary to expectation, the CT in animals spinalized at 12 wk was significantly shorter than that in the 2-wk group. The CT for MG units (n = 105) in spinal cats was also significantly shorter (11%) than that in controls cats (n = 66, 6 cats), and those units identified by their high fatigue index as being of slow or fatigue-resistant type had a shorter CT than units with a low index. No distinction in CT of exercised and nonexercised groups was detected for either muscle. These findings are discussed in relation to the bearing influences of supraspinal and segmental origin have on CT duration in SOL and MG muscles during growth of the kitten. A slight, significant decrease (6%) in the fatigue index of SOL MUs (n = 144) was detected, but the values remained high (mean 0.87).

  14. POST CLOSURE INSPECTION AND MONITORING REPORT FOR CORRECTIVE ACTION UNIT 417: CENTRAL NEVADA TEST AREA - SURFACE, HOT CREEK VALLEY, NEVADA; FOR CALENDAR YEAR 2005

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-04-01

    Corrective Action Unit (CAU) 417, Central Nevada Test Area - Surface, is located in Hot Creek Valley in northern Nye County, Nevada, and consists of three areas commonly referred to as UC-1, UC-3, and UC-4. CAU 417 consists of 34 Corrective Action Sites (CASs) which were closed in 2000 (U. S. Department of Energy, National Nuclear Security Administration Nevada Operations Office, 2001). Three CASs at UC-1 were closed in place with administrative controls. At CAS 58-09-01, Central Mud Pit (CMP), a vegetated soil cover was constructed over the mud pit. At the remaining two sites CAS 58-09-02, Mud Pit and 58-09-05, Mud Pits (3), aboveground monuments and warning signs were installed to mark the CAS boundaries. Three CASs at UC-3 were closed in place with administrative controls. Aboveground monuments and warning signs were installed to mark the site boundaries at CAS 58-09-06, Mud Pits (5), CAS 58-25-01, Spill and CAS 58-10-01, Shaker Pad Area. Two CASs that consist of five sites at UC-4 were closed in place with administrative controls. At CAS 58-09-03, Mud Pits 9, an engineered soil cover was constructed over Mud Pit C. At the remaining three sites in CAS 58-09-03 and at CAS 58-10-05, Shaker Pad Area, aboveground monuments and warning signs were installed to mark the site boundaries. The remaining 26 CASs at CAU 417 were either clean-closed or closed by taking no further action. Quarterly post-closure inspections are performed at the CASs that were closed in place at UC-I, UC-3, and UC-4. During calendar year 2005, site inspections were performed on March 15, June 16, September 22, and December 7. The inspections conducted at the UC-1 CMP documented that the site was in good condition and continued to show integrity of the cover unit. No new cracks or fractures were observed until the December inspection. A crack on the west portion of the cover showed evidence of lateral expansion; however, it is not at an actionable level. The crack will be sealed by filling with

  15. Insights into the problem of alarm fatigue with physiologic monitor devices: a comprehensive observational study of consecutive intensive care unit patients

    National Research Council Canada - National Science Library

    Drew, Barbara J; Harris, Patricia; Zègre-Hemsey, Jessica K; Mammone, Tina; Schindler, Daniel; Salas-Boni, Rebeca; Bai, Yong; Tinoco, Adelita; Ding, Quan; Hu, Xiao

    2014-01-01

    Physiologic monitors are plagued with alarms that create a cacophony of sounds and visual alerts causing "alarm fatigue" which creates an unsafe patient environment because a life-threatening event...

  16. Inventory and Monitoring Plan for Howland Island, Baker Island, Jarvis Island National Wildlife Refuges; Units of the Pacific Remote Islands Marine National Monuments

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This plan documents and prioritizes inventory and monitoring surveys and research currently conducted, and proposed to be conducted, at the Howland Island, Baker...

  17. Entretiens avec les directeurs du Musée juif et du Musée de l'occupation de Riga, les 29 et 30 avril 2011, à Riga, Lettonie Interviews with the Directors of the Jewish Museum and the Museum of the Occupation in Riga, Latvia, on April 29 & 30, 2010

    Directory of Open Access Journals (Sweden)

    Juliette Denis

    2012-01-01

    Full Text Available Depuis la perestroïka et encore plus depuis la chute de l’URSS, de nouvelles collections à vocation historique et mémorielle ont été compilées et ouvertes au public à Riga. Parmi les musées d’histoire de la capitale lettone, deux d'entre eux ont retenu notre attention : le « Musée de l'occupation » et le « Musée juif ». Le premier propose une approche de la Lettonie « occupée » à travers trois moments conformes aux injonctions de la nouvelle historiographie nationale : la « première occupatio...

  18. Post-Closure Monitoring Report for Corrective Action Unit 98, Frenchman Flat, Underground Test Area, Nevada National Security Site, Nevada for Calendar Year 2016 (January 2016–December 2016), Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Farnham, Irene [Navarro, Las Vegas, NV (United States)

    2017-06-01

    Corrective Action Unit (CAU) 98: Frenchman Flat on the Nevada National Security Site was the location of 10 underground nuclear tests. CAU 98 underwent a series of investigations and actions in accordance with the Federal Facility Agreement and Consent Order to assess contamination of groundwater by radionuclides from the tests. A Closure Report completed that process in 2016 and called for long-term monitoring, use restrictions (URs), and institutional controls to protect the public and environment from potential exposure to contaminated groundwater. Three types of monitoring are performed for CAU 98: water quality, water level, and institutional control. These are evaluated to determine whether the UR boundaries remain protective of human health and the environment, and to ensure that the regulatory boundary objectives are being met. Additionally, monitoring data are used to evaluate consistency with the groundwater flow and contaminant transport models because the contaminant boundaries (CBs) calculated with the models are the primary basis of the UR boundaries. In summary, the monitoring results from 2016 indicate the regulatory controls on the closure of CAU 98 remain effective in protection of human health and the environment. Recommendations resulting from this first year of monitoring activities include formally incorporating wells UE-5 PW-1, UE-5 PW-2, and UE-5 PW-3 into the groundwater-level monitoring network given their strategic location in the basin; and early development of a basis for trigger levels for the groundwater-level monitoring given the observed trends. Additionally, it is recommended to improve the Real Estate/Operations Permit process for capturing information important for evaluating the impact of activities on groundwater resources, and to shift the reporting requirement for this annual report from the second quarter of the federal fiscal year (end of March) to the second quarter of the calendar year (end of June).

  19. Inertial measurements units for assessment of the pattern of forward bending among blue-collar workers from the DPhacto cohort

    DEFF Research Database (Denmark)

    Villumsen, Morten; Madeleine, Pascal; Jørgensen, Marie Birk;

    2016-01-01

    Background. New developments in electronics have enabled the use of Inertial Measurement Units (IMUs) to record physical activity in a minimally obstructive manner over several days. Individual, physical and psychosocial risk factors are known to play a role in the development of work-related mus...

  20. Monitoring of levees, bridges, pipelines, and other critical infrastructure during the 2011 flooding in the Mississippi River Basin: Chapter J in 2011 floods of the central United States

    Science.gov (United States)

    Densmore, Brenda K.; Burton, Bethany L.; Dietsch, Benjamin J.; Cannia, James C.; Huizinga, Richard J.

    2014-01-01

    During the 2011 Mississippi River Basin flood, the U.S. Geological Survey evaluated aspects of critical river infrastructure at the request of and in support of local, State, and Federal Agencies. Geotechnical and hydrographic data collected by the U.S. Geological Survey at numerous locations were able to provide needed information about 2011 flood effects to those managing the critical infrastructure. These data were collected and processed in a short time frame to provide managers the ability to make a timely evaluation of the safety of the infrastructure and, when needed, to take action to secure and protect critical infrastructure. Critical infrastructure surveyed by the U.S. Geological Survey included levees, bridges, pipeline crossings, power plant intakes and outlets, and an electrical transmission tower. Capacitively coupled resistivity data collected along the flood-protection levees surrounding the Omaha Public Power District Nebraska City power plant (Missouri River Levee Unit R573), mapped the near-subsurface electrical properties of the levee and the materials immediately below it. The near-subsurface maps provided a better understanding of the levee construction and the nature of the lithology beneath the levee. Comparison of the capacitively coupled resistivity surveys and soil borings indicated that low-resistivity value material composing the levee generally is associated with lean clay and silt to about 2 to 4 meters below the surface, overlying a more resistive layer associated with sand deposits. In general, the resistivity structure becomes more resistive to the south and the southern survey sections correlate well with the borehole data that indicate thinner clay and silt at the surface and thicker sand sequences at depth in these sections. With the resistivity data Omaha Public Power District could focus monitoring efforts on areas with higher resistivity values (coarser-grained deposits or more loosely compacted section), which typically are

  1. Studies for a 10{mu}s, thin, high resolution CMOS pixel sensor for future vertex detectors

    Energy Technology Data Exchange (ETDEWEB)

    Voutsinas, G. [IPHC/IN2P3/CNRS and Universite de Strasbourg, Strasbourg (France); Amar-Youcef, S. [IFK, Goethe-Universitaet, Frankfurt am Main (Germany); Baudot, J.; Bertolone, G.; Brogna, A.; Chon-Sen, N.; Claus, G.; Colledani, C.; Dorokhov, A.; Doziere, G.; Dulinski, W. [IPHC/IN2P3/CNRS and Universite de Strasbourg, Strasbourg (France); Degerli, Y. [IRFU / SEDI (CEA) Saclay (France); De Masi, R. [IPHC/IN2P3/CNRS and Universite de Strasbourg, Strasbourg (France); Deveaux, M. [IFK, Goethe-Universitaet, Frankfurt am Main (Germany); Gelin, M.; Goffe, M.; Hu-Guo, Ch.; Himmi, A.; Jaaskelainen, K.; Koziel, M. [IPHC/IN2P3/CNRS and Universite de Strasbourg, Strasbourg (France)

    2011-06-15

    Future high energy physics (HEP) experiments require detectors with unprecedented performances for track and vertex reconstruction. These requirements call for high precision sensors, with low material budget and short integration time. The development of CMOS sensors for HEP applications was initiated at IPHC Strasbourg more than 10 years ago, motivated by the needs for vertex detectors at the International Linear Collider (ILC) [R. Turchetta et al, NIM A 458 (2001) 677]. Since then several other applications emerged. The first real scale digital CMOS sensor MIMOSA26 equips Flavour Tracker at RHIC, as well as for the microvertex detector of the CBM experiment at FAIR. MIMOSA sensors may also offer attractive performances for the ALICE upgrade at LHC. This paper will demonstrate the substantial performance improvement of CMOS sensors based on a high resistivity epitaxial layer. First studies for integrating the sensors into a detector system will be addressed and finally the way to go to a 10{mu}s readout sensor will be discussed.

  2. A survey on helminthic infection in mice (Mus musculus and rats (Rattus norvegicus and Rattus rattus in Kermanshah, Iran

    Directory of Open Access Journals (Sweden)

    Norollah Pakdel

    2013-06-01

    Full Text Available Parasitic infections of rodents can compromise scientific research as well as the health of the animals and humans. Based on previous studies, infection rate of parasitic helminths is different in various regions of Iran. The current survey was aimed to determine endoparasitic helminths infection in 138 trapped rodents of Kermanshah county, Iran. Mice and rats were trapped using metal snares from January to October 2011 and euthanized. Rodents included 110 Mus musculus (79.00%, 23 Rattus norvegicus (17.00%, and five Rattus rattus (4.00%. The gastrointestinal and respiratory tracts were removed and examined to identify parasitic helminths. The results indicated that 42.02% of examined rodents were infected with eight helminths species, i.e. Trichuris muris (14.49%, Syphacia obvelata (13.76%, Syphacia muris (2.89%, Aspicularis tetrapetra (5.07%, Heterakis spumosa (5.07%, Capillaria hepatica eggs (3.62%, Hyminolepis diminuta (12.30%, and Cystisercus fasciolaris, the larva of Taenia teanieformis (4.34%. Given the results of this study, we concluded that examined rodents were more infected with nematodes than other helminths. As rodents are usually infected with a number of zoonotic parasites, hence control of these animals has an important role in safeguarding public health.

  3. Tissue-Specific Contributions of Paternally Expressed Gene 3 in Lactation and Maternal Care of Mus musculus.

    Directory of Open Access Journals (Sweden)

    Wesley D Frey

    Full Text Available Paternally Expressed Gene 3 (Peg3 is an imprinted gene that controls milk letdown and maternal-caring behaviors. In this study, a conditional knockout allele has been developed in Mus musculus to further characterize these known functions of Peg3 in a tissue-specific manner. The mutant line was first crossed with a germline Cre. The progeny of this cross displayed growth retardation phenotypes. This is consistent with those seen in the previous mutant lines of Peg3, confirming the usefulness of the new mutant allele. The mutant line was subsequently crossed individually with MMTV- and Nkx2.1-Cre lines to test Peg3's roles in the mammary gland and hypothalamus, respectively. According to the results, the milk letdown process was impaired in the nursing females with the Peg3 mutation in the mammary gland, but not in the hypothalamus. This suggests that Peg3's roles in the milk letdown process are more critical in the mammary gland than in the hypothalamus. In contrast, one of the maternal-caring behaviors, nest-building, was interrupted in the females with the mutation in both MMTV- and Nkx2.1-driven lines. Overall, this is the first study to introduce a conditional knockout allele of Peg3 and to further dissect its contribution to mammalian reproduction in a tissue-specific manner.

  4. Discrimination of ultrasonic vocalizations by CBA/CaJ mice (Mus musculus is related to spectrotemporal dissimilarity of vocalizations.

    Directory of Open Access Journals (Sweden)

    Erikson G Neilans

    Full Text Available The function of ultrasonic vocalizations (USVs produced by mice (Mus musculus is a topic of broad interest to many researchers. These USVs differ widely in spectrotemporal characteristics, suggesting different categories of vocalizations, although this has never been behaviorally demonstrated. Although electrophysiological studies indicate that neurons can discriminate among vocalizations at the level of the auditory midbrain, perceptual acuity for vocalizations has yet to be determined. Here, we trained CBA/CaJ mice using operant conditioning to discriminate between different vocalizations and between a spectrotemporally modified vocalization and its original version. Mice were able to discriminate between vocalization types and between manipulated vocalizations, with performance negatively correlating with spectrotemporal similarity. That is, discrimination performance was higher for dissimilar vocalizations and much lower for similar vocalizations. The behavioral data match previous neurophysiological results in the inferior colliculus (IC, using the same stimuli. These findings suggest that the different vocalizations could carry different meanings for the mice. Furthermore, the finding that behavioral discrimination matched neural discrimination in the IC suggests that the IC plays an important role in the perceptual discrimination of vocalizations.

  5. Sodium-dependent myo-inositol transporter 1 is a cellular receptor for Mus cervicolor M813 murine leukemia virus.

    Science.gov (United States)

    Hein, Sibyll; Prassolov, Vladimir; Zhang, Yuanming; Ivanov, Dmitry; Löhler, Jürgen; Ross, Susan R; Stocking, Carol

    2003-05-01

    Retrovirus infection is initiated by binding of the surface (SU) portion of the viral envelope glycoprotein (Env) to specific receptors on cells. This binding triggers conformational changes in the transmembrane portion of Env, leading to membrane fusion and cell entry, and is thus a major determinant of retrovirus tissue and species tropism. The M813 murine leukemia virus (MuLV) is a highly fusogenic gammaretrovirus, isolated from Mus cervicolor, whose host range is limited to mouse cells. To delineate the molecular mechanisms of its restricted host range and its high fusogenic potential, we initiated studies to characterize the cell surface protein that mediates M813 infection. Screening of the T31 mouse-hamster radiation hybrid panel for M813 infectivity localized the receptor gene to the distal end of mouse chromosome 16. Expression of one of the likely candidate genes (slc5a3) within this region in human cells conferred susceptibility to both M813 infection and M813-induced fusogenicity. slc5a3 encodes sodium myo-inositol transporter 1 (SMIT1), thus adding another sodium-dependent transporter to the growing list of proteins used by MuLVs for cell entry. Characterization of SMIT1 orthologues in different species identified several amino acid variations within two extracellular loops that may restrict susceptibility to M813 infection.

  6. Using spike-triggered averaging to characterize motor unit twitch vectors in the first dorsal interosseous.

    Science.gov (United States)

    Suresh, Nina; Kuo, Art; Heckman, C J; Rymer, William Zev

    2012-01-01

    Earlier studies in multifunctional muscles such as the first dorsal interosseous (FDI) have demonstrated that the selection and control of motor units (MUs) can vary as a function of generated force direction. While directionally dependent motor unit recruitment and rate properties imply that there may also be differential mechanical action, this has yet to be directly demonstrated. Our objective was to determine whether there exists a range of force vectors from different motor units in the FDI muscle within individual subjects. We utilized the spike-triggered averaging (STA) method to derive force twitch estimates from single motor units. We derived MU twitch direction from the ratio of individual twitch estimates recorded concurrently from the load cell. Fifteen units from 2 subjects were used to determine MU force vectors. We were able to estimate force twitch vectors from 7-8 different MUs in each subject. The results of our study suggest that there is varied mechanical action of motor units in the FDI. It is thus possible that differential activation of individual MUs in the FDI is a function of varied mechanical action.

  7. Model of experimental infection in healthy and immunosuppressed swiss albino mice (Mus musculus using Candida albicans strains with different patterns of enzymatic activity Modelo de infecção experimental em camundongos albino swiss (Mus musculus sadios e imunossuprimidos utilizando cepas de Candida albicans com diferentes padrões de atividade enzimática

    Directory of Open Access Journals (Sweden)

    Guilherme M. Chaves

    2004-12-01

    Full Text Available With the purpose to evaluate Candida albicans virulence in vivo, two strains selected were based on their phospholipase and proteinase activity, and used in a model of experimental infection. One strain, isolated from vaginal secretion, was stocked at the URM Culture Collection for 43 years and presented high phospholipase (Pz=0.217 and proteinase (1.386 U.mL-1 activity. The other strain was a fresh strain isolated from oropharyngeal secretion of an AIDS patient, and presented low phospholipase (Pz=0.482 and proteinase (0.780 U.mL-1 activity. The strains were inoculated via intraperitoneum in immunosuppressed and non-immunosuppressed mice (Mus musculus and the infection was evaluated over a period of 21 days. Liver, spleen, lungs and kidneys were aseptically removed and the blood of the animals was collected every 72 h. The number of colony forming units (c.f.u isolated from each organ was counted and a histopathologic examination was performed. The freshly isolated strain was more virulent than the stocked strain, as shown by the number of positive cultures and severity of the lesions observed at the histopathologic examination. A correlation between the in vitro enzymatic activity and the in vivo virulence was not observed.Com o objetivo de avaliar a virulência de Candida albicans in vivo, foram selecionadas duas cepas de acordo com a atividade enzimática de fosfolipase e protease, para utilização em modelo de infecção experimental. Utilizou-se um isolado de secreção vaginal, estocado na Micoteca URM por 43 anos com alta atividade de fosfolipase (Pz=0.217 e de protease (1.386 U.mL-1, e outro recém-isolado de secreção orofaríngea de paciente com AIDS, o qual apresentou baixa atividade de fosfolipase (Pz=0.482 e de protease (0.780 U.mL-1. As amostras foram inoculadas por via intra-peritoneal em camundongos (Mus musculus na presença e ausência de imunossupressão e a infecção foi avaliada durante 21 dias. A cada 72 h foram

  8. Paradigm Shifts in Voluntary Force Control and Motor Unit Behaviors with the Manipulated Size of Visual Error Perception

    Science.gov (United States)

    Chen, Yi-Ching; Lin, Yen-Ting; Chang, Gwo-Ching; Hwang, Ing-Shiou

    2017-01-01

    The detection of error information is an essential prerequisite of a feedback-based movement. This study investigated the differential behavior and neurophysiological mechanisms of a cyclic force-tracking task using error-reducing and error-enhancing feedback. The discharge patterns of a relatively large number of motor units (MUs) were assessed with custom-designed multi-channel surface electromyography following mathematical decomposition of the experimentally-measured signals. Force characteristics, force-discharge relation, and phase-locking cortical activities in the contralateral motor cortex to individual MUs were contrasted among the low (LSF), normal (NSF), and high scaling factor (HSF) conditions, in which the sizes of online execution errors were displayed with various amplification ratios. Along with a spectral shift of the force output toward a lower band, force output with a more phase-lead became less irregular, and tracking accuracy was worse in the LSF condition than in the HSF condition. The coherent discharge of high phasic (HP) MUs with the target signal was greater, and inter-spike intervals were larger, in the LSF condition than in the HSF condition. Force-tracking in the LSF condition manifested with stronger phase-locked EEG activity in the contralateral motor cortex to discharge of the (HP) MUs (LSF > NSF, HSF). The coherent discharge of the (HP) MUs during the cyclic force-tracking predominated the force-discharge relation, which increased inversely to the error scaling factor. In conclusion, the size of visualized error gates motor unit discharge, force-discharge relation, and the relative influences of the feedback and feedforward processes on force control. A smaller visualized error size favors voluntary force control using a feedforward process, in relation to a selective central modulation that enhance the coherent discharge of (HP) MUs. PMID:28348530

  9. Shared performance monitor in a multiprocessor system

    Science.gov (United States)

    Chiu, George; Gara, Alan G; Salapura, Valentina

    2014-12-02

    A performance monitoring unit (PMU) and method for monitoring performance of events occurring in a multiprocessor system. The multiprocessor system comprises a plurality of processor devices units, each processor device for generating signals representing occurrences of events in the processor device, and, a single shared counter resource for performance monitoring. The performance monitor unit is shared by all processor cores in the multiprocessor system. The PMU is further programmed to monitor event signals issued from non-processor devices.

  10. Material monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Kotter, W.; Zirker, L.; Hancock, J.A.

    1995-11-01

    Waste Reduction Operations Complex (WROC) facilities are located at the Idaho National Engineering Laboratory (INEL). The overall goal for the Pollution Prevention/Waste Minimization Unit is to identify and establish the correct amount of waste generated so that it can be reduced. Quarterly, the INEL Pollution Prevention (P2) Unit compares the projected amount of waste generated per process with the actual amount generated. Examples of waste streams that would be addresses for our facility would include be are not limited to: Maintenance, Upgrades, Office and Scrap Metal. There are three potential sources of this variance: inaccurate identification of those who generate the waste; inaccurate identification of the process that generates the waste; and inaccurate measurement of the actual amount generated. The Materials Monitoring Program was proposed to identify the sources of variance and reduce the variance to an acceptable level. Prior to the implementation of the Material Monitoring Program, all information that was gathered and recorded was done so through an informal estimation of waste generated by various personnel concerned with each processes. Due to the inaccuracy of the prior information gathering system, the Material Monitoring Program was established. The heart of this program consists of two main parts. In the first part potential waste generators provide information on projected waste generation process. In the second part, Maintenance, Office, Scrap Metal and Facility Upgrade wastes from given processes is disposed within the appropriate bin dedicated to that process. The Material Monitoring Program allows for the more accurate gathering of information on the various waste types that are being generated quarterly.

  11. FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress

    DEFF Research Database (Denmark)

    Fugger, Kasper; Chu, Wai Kit; Haahr, Peter

    2013-01-01

    The molecular events occurring following the disruption of DNA replication forks are poorly characterized, despite extensive use of replication inhibitors such as hydroxyurea in the treatment of malignancies. Here, we identify a key role for the FBH1 helicase in mediating DNA double-strand break...... formation following replication inhibition. We show that FBH1-deficient cells are resistant to killing by hydroxyurea, and exhibit impaired activation of the pro-apoptotic factor p53, consistent with decreased DNA double-strand break formation. Similar findings were obtained in murine ES cells carrying...... disrupted alleles of Fbh1. We also show that FBH1 through its helicase activity co-operates with the MUS81 nuclease in promoting the endonucleolytic DNA cleavage following prolonged replication stress. Accordingly, MUS81 and EME1-depleted cells show increased resistance to the cytotoxic effects...

  12. Contribution à l'étude des Hepialidae (22ème note) : Hepialidae du Musée de Leiden

    NARCIS (Netherlands)

    Viette, P.E.L.

    1950-01-01

    On trouvera ici l'étude d'une partie des Hepialidae du Musée de Leiden que le Dr. van Regteren Altena a bien voulu nous confier pour étude, ce dont le remercions vivement. Nous y avons ajouté l'étude de quatre espèces du British Museum (N.H.) et une du Museum de Paris. HÉPIALIDES DE LA NOUVELLE GUIN

  13. Pengaruh Ekstrak Daun Sambiloto (Andrographis paniculata) terhadap Struktur Mikroanatomi Hepar dan Kadar Glutamat Piruvat Transaminase Serum Mencit (Mus musculus) yang Terpapar Diazinon

    OpenAIRE

    TRI WULANDARI; MARTI HARINI; SHANTI LISTYAWATI

    2007-01-01

    Diazinon is a pesticide which is often using by farmer to kill insect as theenemy of the plant. The over using of pesticide may result in the remaining of diazinon residue in farming product. This residue can cause the damage of body tissue, especially liver. The aim of research were to find out the effect of leaves sambiloto (Andrographis paniculata Ness.) extract on microanatomic structure of liver and serum glutamate pyruvate transaminase (GPT) level of mice (Mus musculus L.) expose...

  14. Aktivitas Penyembuhan Luka Sediaan Topikal Ekstrak Bawang Merah (Allium cepa terhadap Luka Sayat Kulit Mencit (Mus Musculus (THE ACTIVITY OF TOPICAL EXTRACT OF ONIONS (ALLIUM CEPA ON WOUND HEALING PROCESS IN MICE (MUS MUSCULUS

    Directory of Open Access Journals (Sweden)

    Visa Yunanda

    2017-01-01

    Full Text Available Wound healing is a physiological response of the body to restore continuity, structure and function ofthe injured tissue. Onion is one of the plants that are empirically used by the community to heal wounds.The purpose of this study was to observe the effect of topical extract of onions (Allium cepa on woundhealing process in mice (Mus musculus strain BalbC. This study used the posttest-only control groupdesign with completely randomized design (CRD. The samples were 12 male mice with weight ranged of22-32 g divided into four treatments; i.e.: Vaseline, topical extract of onion 5%, topical extract of onion30% and topical extract of onion 55% with 3 replications. Wound healing evaluated macroscopically toobserve hyperemia, wound contraction, granulation, crusting and pus production; and microscopically bycounting the number of fibroblasts on day 10. Hyperemia, granulation, crusting and pus production wereanalyzed descriptively. Wound contraction and the number of fibroblasts were analyzed using ANOVA(p<0.05 and followed with Duncan’s test (p<0,05. Descriptive observations obtained hyperemia lasteduntil day 3, granulation in wounds used topical extract of onion 30% and 55% were faster than the other,crusting lasted until day 6 and the production of pus was not found in any treatment. Statistical testresults showed that topical extract of onion 55% significantly affected wound contraction and topicalextract of onion 30% and 55% significantly affected maturation, which characterized by the decreasednumber of fibroblasts. The results of this study showed that topical extract of onion had significant effect(p<0.05 on wound healing and the effect was in line with the increased concentration of the onion extract.

  15. On the use of statistics and kriging to the monitoring of hydro generating units at Hydro-Quebec; Application de la statistique et du krigeage a la surveillance de groupes hydroelectriques a Hydro-Quebec

    Energy Technology Data Exchange (ETDEWEB)

    Leonard, F.

    1996-12-31

    Optimizing the preventing monitoring of a water current power generator requires a good statistical representation. But the unit working rate is always one of the three most interesting ones, which results in poor statistical data for any other working rate. Kriging has been used, in a simplified and efficient way that takes into account for each state the preceding state and the following one (dual kriging). In addition, a novel approach for computing the standard deviation of a distribution is described, as well as a method for estimating the bias on the interpolation used to calculate the latter`s range of validity. (D.L.) 32 refs.

  16. Technology monitoring; Technologie-Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Eicher, H.; Rigassi, R. [Eicher und Pauli AG, Liestal (Switzerland); Ott, W. [Econcept AG, Zuerich (Switzerland)

    2003-07-01

    This study made for the Swiss Federal Office of Energy (SFOE) examines ways of systematically monitoring energy technology development and the cost of such technologies in order to pave the way to a basis for judging the economic development of new energy technologies. Initial results of a survey of the past development of these technologies are presented and estimates are made of future developments in the areas of motor-based combined heat and power systems, fuel-cell heating units for single-family homes and apartment buildings, air/water heat pumps for new housing projects and high-performance thermal insulation. The methodology used for the monitoring and analysis of the various technologies is described. Tables and diagrams illustrate the present situation and development potential of various fields of technology.

  17. De Gainsborough à Turner : l'âge d'or du paysage et du portrait anglais dans les collections du musée du Louvre

    OpenAIRE

    Adrien, Muriel

    2015-01-01

    L’exposition De Gainsborough à Turner : l'âge d'or du paysage et du portrait anglais dans les collections du musée du Louvre co-organisée par le Musée du Louvre, le Musée d’Art et d’Archéologie de Valence et le Musée des Beaux-arts de Quimper présentait une sélection de 35 peintures de la collection du Louvre, complétée par 38 dessins du département des Arts Graphiques. Les commissaires de l'exposition étaient : Guillaume Faroult, conservateur en charge des peintures françaises du 18ème siècl...

  18. Genome patterns of selection and introgression of haplotypes in natural populations of the house mouse (Mus musculus.

    Directory of Open Access Journals (Sweden)

    Fabian Staubach

    Full Text Available General parameters of selection, such as the frequency and strength of positive selection in natural populations or the role of introgression, are still insufficiently understood. The house mouse (Mus musculus is a particularly well-suited model system to approach such questions, since it has a defined history of splits into subspecies and populations and since extensive genome information is available. We have used high-density single-nucleotide polymorphism (SNP typing arrays to assess genomic patterns of positive selection and introgression of alleles in two natural populations of each of the subspecies M. m. domesticus and M. m. musculus. Applying different statistical procedures, we find a large number of regions subject to apparent selective sweeps, indicating frequent positive selection on rare alleles or novel mutations. Genes in the regions include well-studied imprinted loci (e.g. Plagl1/Zac1, homologues of human genes involved in adaptations (e.g. alpha-amylase genes or in genetic diseases (e.g. Huntingtin and Parkin. Haplotype matching between the two subspecies reveals a large number of haplotypes that show patterns of introgression from specific populations of the respective other subspecies, with at least 10% of the genome being affected by partial or full introgression. Using neutral simulations for comparison, we find that the size and the fraction of introgressed haplotypes are not compatible with a pure migration or incomplete lineage sorting model. Hence, it appears that introgressed haplotypes can rise in frequency due to positive selection and thus can contribute to the adaptive genomic landscape of natural populations. Our data support the notion that natural genomes are subject to complex adaptive processes, including the introgression of haplotypes from other differentiated populations or species at a larger scale than previously assumed for animals. This implies that some of the admixture found in inbred strains of mice

  19. Detección temprana de resistencia a Mycosphaerella fijiensis en genotipos locales de Musáceas en Ecuador

    Directory of Open Access Journals (Sweden)

    Galo Cedeño García

    2017-01-01

    Full Text Available El objetivo de la investigación fue determinar la reacción de 14 genotipos de musáceas frente a Mycosphaerella fijensis, agente causal de la Sigatoka negra. Se condujeron dos experimentos en el Departamento de Protección Vegetal de la Estación Experimental P ichilingue del Instituto Nacional de Investigaciones Agropecuarias (INIAP, Ecuador. Los genotipos evaluados fueron: banano Orito (AA, Guineo de jardín, Williams, Filipino, Gros Michel, Mulato y Morado, del genoma (AAA, y los plátanos Limeño, Maqueño, Do minico, Dominico - Hartón, Dominico gigante, Dominico negro y Barraganete, del genoma AAB. Se usaron dos métodos de inoculación: a in vitro sobre fragmentos de hoja con una suspensión de conidios y b inoculación de pl á ntulas de ocho semanas de edad con una suspensión micelial. En el primer caso se midió el periodo de incubación (PI y el número de lesiones a los 14 y 20 días después de la inoculación (DDI. En invernadero, se registró el PI, tiempo de evolución de síntomas (TES y tiempo de desarrollo de la enfermedad (TDE. Se determinaron diferencias estadísticas significativas (p ≤ 0 , 05 para todas las variables evaluadas; los cultivares Orito (AA y Limeño (AAB calificaron como resistentes, mientras que todos los demás fueron susceptibles, aunque mostra ron un rango de variabilidad en la respuesta a las inoculaciones .

  20. Ablation of CdTe with 100 {mu}s Nd:YAG laser pulses: dependence on target preparation method

    Energy Technology Data Exchange (ETDEWEB)

    Rzeszutek, J. [Instytut Fizyki, Politechnika Poznanska, ul. Nieszawska 13a, 61-965 Poznan (Poland); Savchuk, V. [Pidstryhach Institute for Applied Problems of Mechanics and Mathematics, National Academy of Sciences of Ukraine, 3B Naukova Street, 79601 Lviv (Ukraine); Oszwaldowski, M.

    2008-01-15

    The results of experimental studies of the ablation of CdTe with a pulsed Nd:YAG laser (wavelength 1064 nm) performed with 100 {mu}s pulses and repetition time of 35 Hz are presented for the pulse energy range from 0.13 to 0.25 J. The main goal is to elucidate the dependence of the ablation process on the target preparation method. The investigation of the vapour stream intensity and chemical composition and their evolution with time are performed with a quadrupole mass spectrometer synchronized with the laser pulses. These studies are performed for three kinds of targets: a target made of CdTe bulk crystal (BC target), a target made of CdTe fine powder pressed under the pressure of 700 atm (PP target), and a target made of loose CdTe powder (N-PP target). The applicability of these targets for obtaining high quality CdTe thin films is determined. The best chemical composition of the vapour stream can be obtained with the BC target. A major drawback of this target is the energetic threshold for ablation with Nd:YAG laser and resulting delay in the ablation process above the threshold. The advantage of powder targets over BC target is the lack of any ablation threshold or delay. Weaker angular dependence of the particle emission (associated with the surface roughness), if confirmed in further experiments, can be the most important advantage of PP and N-PP targets. (copyright 2007 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  1. Devising assisted reproductive technologies for wild-derived strains of mice: 37 strains from five subspecies of Mus musculus.

    Directory of Open Access Journals (Sweden)

    Keiji Mochida

    Full Text Available Wild-derived mice have long offered invaluable experimental models for mouse genetics because of their high evolutionary divergence from laboratory mice. A number of wild-derived strains are available from the RIKEN BioResource Center (BRC, but they have been maintained as living stocks because of the unavailability of assisted reproductive technology (ART. In this study, we sought to devise ART for 37 wild-derived strains from five subspecies of Mus musculus maintained at the BRC. Superovulation of females was effective (more than 15 oocytes per female for 34 out of 37 strains by treatment with either equine chorionic gonadotropin or anti-inhibin serum, depending on their genetic background (subspecies. The collected oocytes could be fertilized in vitro at mean rates of 79.0% and 54.6% by the optimized protocol using fresh or frozen-thawed spermatozoa, respectively. They were cryopreserved at the 2-cell stage by vitrification with an ethylene glycol-based solution. In total, 94.6% of cryopreserved embryos survived the vitrification procedure and restored their normal morphology after warming. A conventional embryo transfer protocol could be applied to 25 out of the 35 strains tested. In the remaining 10 strains, live offspring could be obtained by a modified embryo transfer protocol using cyclosporin A treatment and co-transfer of ICR (laboratory mouse strain embryos. Thus, ART for 37 wild-derived strains was devised successfully and is now routinely used for their preservation and transportation. The information provided here might facilitate broader use and wider distribution of wild-derived mice for biomedical research.

  2. WOUND HEALING ACTIVITY OF UNGUENTUM DOSAGE FORM OF ETHANOLIC EXTRACTS OF Areca catechu L. NUT IN Mus musculus albinus

    Directory of Open Access Journals (Sweden)

    Azizah Vonna

    2015-10-01

    Full Text Available The activity test of ethanol extract of betel nut ointment (Areca catechu L. in wound healing on mice (Mus musculus albinus has been carried out to determine the ability of the ethanol extract of betel nut ointment in wound healing and determine the concentration which was accelerate the wound healing on mice between 2 concentrations. This experimental research method used completely randomized design (CRD using 20 mices divided into 4 treatment groups ; ointment base, povidone iodine ointment, ethanol extract of betel nut ointment (SEEBP 2% and SEEBP 4%. Each treatment groups was tested in the incision which was made along the 15 mm parallel to the spine (Os. Vetebre with the depth until subcutaneous skin layers. The ointment was applied twice a day for about 21 days and observed changes every day for during the period of observation. The results showed that the average length of time of the scab formation, the scab exfoliation, and the wound healing successively are for the ointment base was 6.6; 10.2 and 18.2 days, povidone iodine ointment was 7; 11.2 and 14.8 days, SEEBP 2% was 5.75; 7.75 and 13.25 days, SEEBP 4% was 4.2; 8.8 and 12.8 days. ANOVA and LSD results of scab formation time showed a significant difference between SEEBP 4% with base ointment and povidone iodine ointment (p <0.05. Results of the exfoliation scab showed a significance difference between SEEBP 2% with base ointment and povidone iodine ointment (p <0.05. The duration of wound healing showed that there was significance difference between SEEBP 2%, SEBP 4% and povidone iodine ointment with ointment base  (p<0.05.Thus, betel nut ointment as an effect on healing process. The concentration which can accelerate wound healing in mice is SEEBP 4%.

  3. Polymorphism in hybrid male sterility in wild-derived Mus musculus musculus strains on proximal chromosome 17.

    Science.gov (United States)

    Vyskocilová, Martina; Prazanová, Gabriela; Piálek, Jaroslav

    2009-02-01

    The hybrid sterility-1 (Hst1) locus at Chr 17 causes male sterility in crosses between the house mouse subspecies Mus musculus domesticus (Mmd) and M. m. musculus (Mmm). This locus has been defined by its polymorphic variants in two laboratory strains (Mmd genome) when mated to PWD/Ph mice (Mmm genome): C57BL/10 (carrying the sterile allele) and C3H (fertile allele). The occurrence of sterile and/or fertile (wild Mmm x C57BL)F1 males is evidence that polymorphism for this trait also exists in natural populations of Mmm; however, the nature of this polymorphism remains unclear. Therefore, we derived two wild-origin Mmm strains, STUS and STUF, that produce sterile and fertile males, respectively, in crosses with C57BL mice. To determine the genetic basis underlying male fertility, the (STUS x STUF)F1 females were mated to C57BL/10 J males. About one-third of resulting hybrid males (33.8%) had a significantly smaller epididymis and testes than parental animals and lacked spermatozoa due to meiotic arrest. A further one-fifth of males (20.3%) also had anomalous reproductive traits but produced some spermatozoa. The remaining fertile males (45.9%) displayed no deviation from values found in parental individuals. QTL analysis of the progeny revealed strong associations of male fitness components with the proximal end of Chr 17, and a significant effect of the central section of Chr X on testes mass. The data suggest that genetic incompatibilities associated with male sterility have evolved independently at the proximal end of Chr 17 and are polymorphic within both Mmd and Mmm genomes.

  4. Design of Mobile Communication Base Station Centralized Monitoring Unit Based on EDGE%基于EDGE的通信基站环境监控单元的设计

    Institute of Scientific and Technical Information of China (English)

    董裕艺; 陆昕为; 黎春强; 钟文清

    2012-01-01

    对移动基站环境集中监控系统的历史及现状进行了简要介绍,分析了基于各种传输方式的基站环境监控系统的优缺点,利用增强型数据速率GSM演进技术(Enhanced Data Rate for GSM Evolution,EDGE)对基站动力环境各项参数进行采集及机房各路摄像头进行监控、存储,提出了基于EDGE的基站集中监控单元的设计思路,该设计具有费用低廉、可靠性高和及时性好的优点,有着很好的应用推广前景。%The history and current situation of environmental monitoring unit of mobile base station was introduced. A centralized monitoring unit based on EDGE with low cost, high reliability and real-time performance was presented. It uses enhanced data rate for GSM evolution technology, which can collect and process power and environment parameters in time. This design features low cost, high reliability and good in-time capability. Which presents a broad application prospect.

  5. 血液透析室卫生消毒质量监测%MONITORING OF HYGIENE AND DISINFECTION QUALITY IN HEMODIALYSIS UNIT

    Institute of Scientific and Technical Information of China (English)

    龙岩; 康万军; 曾雪艳; 周婷; 乔羽; 袁悦

    2013-01-01

    Objective To investigate the disinfection quality in hemodialysis unit in order to improve the management of nosocomial infection. Methods Sampling on site was used to survey the health disinfection quality of hemodialysis unit in this hospital. Results From 2005 to 2011 year, six years continuous survillance showed that the qualified rates of disinfection for dialysis water and dialysate were 99. 3% and 94. 2% , respectively. Endotoxin level in the dialysis water and di-alysate did not exceed the standards. For air disinfection, the qualified rate was 95. 4% in hemodialysis unit. For both surface and hands of medical workers, the rates were 100% . Conclusion The health disinfection quality of the hemodialysis unit is good, which can be in favour of preventing nosocomial infection.%目的 了解血液透析室卫生消毒质量,加强医院感染管理.方法 通过采样检测方法,对该医院血液透析室卫生消毒质量进行了监测.结果 通过2005-2011年7年连续监测,该医院透析室的透析用水卫生质量合格率达到99.3%,透析液卫生质量合格率为94.2%,透析用水和透析液中内毒素无超标现象.透析室内空气卫生质量合格率达到95.4%,物体表面及医务人员手消毒效果合格率均为100%.结论 该医院血液透析室卫生消毒质量较好,有利于防控医院感染的发生.

  6. Atmospheric measurements of CDDs, CDFs and coplanar PCBs in rural and remote locations of the United States in the year 2001 from the National Dioxin Air Monitoring Network (NDAMN)

    Energy Technology Data Exchange (ETDEWEB)

    Cleverly, D. [National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency (United States); Winters, D. [Office of Prevention, Pesticides and Toxic Substances, U.S. Environmental Protection Agency, WA, DC (United States); Ferrario, J.; Dupuy, A.; Byrne, C. [Environmental Chemistry Lab., U.S. Environmental Protection Agency, Stennis Space Center, MS (United States); Riggs, K.; Hartford, P.; Joseph, D.; Wisbith, T. [Battelle Memorial Inst., Columbus, OH (United States)

    2004-09-15

    The U.S. EPA has established a National Dioxin Air Monitoring Network (NDAMN) to address three primary objectives: (1) to determine the atmospheric levels and occurrences of dioxin-like compounds in rural and agricultural areas where livestock, poultry and animal feed crops are grown; (2) to provide measurements of atmospheric levels of dioxin-like compounds in remote areas of the U.S.; and (3) to provide information regarding the long-range and transboundary transport of dioxin-like compounds in air over the United States. Figure 1 shows the locations of NDAMN sites. Previously EPA has reported on the preliminary results of monitoring at 9 rural locations from June1998 through December 19991, and calendar year 2000. The year 1999 measurement at the 9 rural stations indicated an annual mean TEQ{sub DF}-WHO{sub 98} air concentration of about 11.3 fg m{sup -3}. In the year 2000, the mean of 18 rural stations and 8 remote areas were 14.6 fg m{sup -3} and 2.0 fg m{sup -3}, respectively. Since this reporting, NDAMN has been extended to include additional stations. We are reporting the air monitoring results of NDAMN for calendar year 2001 at both rural and remote sites in the U.S. The rural sites are indicated as circles and remote sites are indicted as squares on Figure 1.

  7. POST CLOSURE INSPECTION AND MONITORING REPORT FOR CORRECTIVE ACTION UNIT 110: AREA 3 WMD U-3AX/BL CRATER, NEVADA TEST SITE, NEVADA FOR THE PERIOD JULY 2004 - JUNE 2005

    Energy Technology Data Exchange (ETDEWEB)

    BECHTEL NEVADA

    2005-08-01

    This Post-Closure Inspection and Monitoring report provides the results of inspections and monitoring for Corrective Action Unit (CAU) 110, Area 3 Waste Management Division (WMD) U-3ax/bl Crater. This report includes an analysis and summary of the site inspections, repairs and maintenance, meteorological information, and soil moisture monitoring data obtained at CAU 110, for the annual period July 2004 through June 2005. Site inspections of the cover were performed quarterly to identify any significant changes to the site requiring action. The overall condition of the cover, cover vegetation, perimeter fence, and use restriction warning signs was good. Settling was observed that exceeded the action level as specified in Section VII.B.7 of the Hazardous Waste Permit Number NEV HW009 (Nevada Division of Environmental Protection, 2000). This permit states that cracks or settling greater than 15 centimeters (cm) (6 inches [in]) deep that extend 1.0 meter (m) (3 feet [ft]) or more on the cover will be evaluated and repaired within 60 days of detection.

  8. From stroke unit care to stroke care unit

    NARCIS (Netherlands)

    De Keyser, J; Sulter, G.

    1999-01-01

    In some stroke units continuous monitoring of blood pressure, electrocardiogram, body temperature, and oxygen saturation has become an integral part of the management of acute stroke. In addition, regular measurements of blood glucose are performed. Stroke units equipped with such monitoring facilit

  9. From stroke unit care to stroke care unit

    NARCIS (Netherlands)

    De Keyser, J; Sulter, G.

    1999-01-01

    In some stroke units continuous monitoring of blood pressure, electrocardiogram, body temperature, and oxygen saturation has become an integral part of the management of acute stroke. In addition, regular measurements of blood glucose are performed. Stroke units equipped with such monitoring

  10. The Integration of On-Line Monitoring and Reconfiguration Functions using EDAA - European design and Automation Association1149.4 Into a Safety Critical Automotive Electronic Control Unit

    CERN Document Server

    Jeffrey, C; Prosser, S; Lickess, M; Richardson, A; Riches, S

    2011-01-01

    This paper presents an innovative application of EDAA - European design and Automation Association 1149.4 and the Integrated Diagnostic Reconfiguration (IDR) as tools for the implementation of an embedded test solution for an Automotive Electronic Control Unit implemented as a fully integrated mixed signal system. The paper described how the test architecture can be used for fault avoidance with results from a hardware prototype presented. The paper concludes that fault avoidance can be integrated into mixed signal electronic systems to handle key failure modes.

  11. Pharmacist-led implementation of a vancomycin guideline across medical and surgical units: impact on clinical behavior and therapeutic drug monitoring outcomes

    Directory of Open Access Journals (Sweden)

    Phillips CJ

    2015-10-01

    Full Text Available Cameron J Phillips,1–3 David L Gordon3,4 1Division of Pharmacy, SA Pharmacy, Flinders Medical Centre, Bedford Park, 2School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, 3Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, Adelaide, 4Department of Microbiology and Infectious Diseases, SA Pathology, Flinders Medical Centre, Bedford Park, SA, Australia Background: Vancomycin is the antibiotic of choice for the treatment of serious infections such as methicillin-resistant Staphylococcus aureus (MRSA. Inappropriate prescribing of vancomycin can lead to therapeutic failure, antibiotic resistance, and drug toxicity. Objective: To examine the effectiveness of pharmacist-led implementation of a clinical practice guideline for vancomycin dosing and monitoring in a teaching hospital. Methods: An observational pre–post study design was undertaken to evaluate the implementation of the vancomycin guideline. The implementation strategy principally involved education, clinical vignettes, and provision of pocket guidelines to accompany release of the guideline to the hospital Intranet. The target cohort for clinical behavioral change was junior medical officers, as they perform the majority of prescribing and monitoring of vancomycin in hospitals. Assessment measures were recorded for vancomycin prescribing, therapeutic drug monitoring, and patient outcomes. Results: Ninety-nine patients, 53 pre- and 46 post-implementation, were included in the study. Prescribing of a loading dose increased from 9% to 28% (P=0.02, and guideline adherence to starting maintenance dosing increased from 53% to 63% (P=0.32. Dose adjustment by doctors when blood concentrations were outside target increased from 53% to 71% (P=0.12, and correct timing of initial concentration measurement increased from 43% to 57% (P=0.23. Appropriately timed trough concentrations improved from 73% to 81% (P=0.08. Pre-dose (trough

  12. Aspects of the life history of Muspicea borreli (Nematoda: Muspiceidae, parasite of the house mouse (Mus domesticus in Australia

    Directory of Open Access Journals (Sweden)

    Spratt D.M.

    2002-09-01

    Full Text Available Prevalence of Muspicea borreli (Nematoda infection in wild populations of Mus domesticus in forests in southeastern New South Wales and in rural Canberra, Australia was variable, relatively low and the parasite occurred predominantly in male mice. Experimental infection of BALB/c mice occurred only via subcutaneous inoculation but was achieved using i adults containing embryonating eggs, ii adults containing active larvae and iii active larvae dissected from the uterus of female worms. Experimental infection was not established using adults containing unembryonated eggs and was not established via intraperitoneal, percutaneous nor oral routes. Evidence indicates that larvae develop to the infective stage in the uterus of the adult worm, suggests that an obligate developmental phase on the host skin does not occur and that autoinfection is possible. Experimental infection predominated in males; females rarely became infected. When male BALB/c mice were inoculated subcutaneously with M. borreli, immediately paired with an uninoculated female and permitted to breed for 90 days, infection was found in male and female offspring only of the second and subsequent litters or in the breeding female partner. Transmission to the young occurred within 21 days of birth and fifth-stage M. borreli were found in offspring of the second and subsequent litters only after 35 or more days. However, when a male was inoculated but mating delayed for 23 days, infection was found in progeny of the first and second litters. The life cycle is direct and the prepatent period in BALB/c mice is estimated at 50-60 days. The precise mode of transmission of the parasite in breeding pairs of mice was not determined but larvae remained active for approximately an hour in balanced saline solutions (pH = 7.2 and in human saliva but died under conditions emulating free-living (tap water pH = 7.1 and stomach (pepsin solution pH = 2 environments. Transmission was not effected by

  13. Efecto del extracto del fruto de Physalis peruviana "tomatillo" en Mus musculus var. swis con hiperlipidemia inducida.

    Directory of Open Access Journals (Sweden)

    Julio Campos Florián

    2011-01-01

    Full Text Available El objetivo de la presente i nvestigación fue determinar la actividad hipolipidémica del fruto de Physalis peruviana “tomatillo” en un modelo de hiperlipidemia aguda inducida con tritón. Se utilizaron Mus musculus var. swis machos como animales de experimentación. Se trabajó con cuatro grupos de ratones, el grupo blanco recibió agua destilada por vía oral y solución salina fisiológica por vía intraperitoneal, el grupo control recibió agua destilada por vía oral y tritón por vía intraperitoneal, el grupo problema 1 recibió por vía oral 0.05g/100g del extracto de Physalis peruviana y tritón por vía intraperitoneal y el grupo problema 2 recibió por vía oral 0.2g/100g del extracto de Physalis peruviana y tritón por vía intraperitoneal. Luego de 24 horas de administrar los tratamientos se re alizaron las mediciones en suero de las concentraciones de colesterol y triglicéridos. Los niveles promedio de colesterol (mg/dL fueron: 58.87±11.54 (blanco, 121.71±15.00 (control, 58.08±9. 21 (problema 1 y 66.78±16.77 (problema 2. Los niveles promedio de triglicéridos (g/L fueron: 0.48±0.07 (blanco, 1.84±0.18 (control, 0.34±0.10 (problema 1 y 0.94±0.25 (problema 2. Se encontró reducciones significativas (p<0.000, tanto de las concentraciones de colesterol como de triglicéridos en relación a las o btenidas en el grupo tratado sólo con tritón.

  14. Development of monitoring unit for shaft generator set syetem with performances of variable speed and constant frequency%变速恒频轴带发电机组监控系统的研制

    Institute of Scientific and Technical Information of China (English)

    洪鹏鹏; 南余荣; 石健将

    2013-01-01

    Aiming at solving the problems of low efficiency, high pollution and complex monitoring in the traditional hybrid propulsion system on ship, the shaft generator set system with performances of variable speed and constant frequency was applied in the new hybrid propulsion system. A four-quadrant inverter was added between the shaft generator and the micro grid on ship, whose performances were researched in different working modes. A monitoring unit was developed to communicate with the controllers through CAN bus and the ship information management platform through Profibus. A TMS320F28335 was applied as the controller of the monitoring unit, while the LCD module was used as the displaying interface. The display of system state, working parameters, commands and data transferred were all completed by the monitoring unit. The experimental results indicate that the new hybrid propulsion system can work steadily in different working modes, while reducing the pollution and improving the efficiency of the system. At the same time, the monitoring unit is human friendly with flexiable operating performance and the communication is stable and reliable, which is fit for industrial application.%针对传统的船舶混合推进系统中存在效率低、污染高、工作模式单一、监控麻烦等问题,将变速恒频轴带发电机组系统应用于新型混合推进系统,在传统的轴带发电机和船舶微电网间添加了一个四象限变频器,对新型混合推进系统在不同工作模式下的系统性能进行了研究;同时设计了一个监控系统,采用TMS320F28335作为控制芯片,与底层控制器之间采用CAN总线通信,与上层的船舶综合信息管理平台之间采用Profibus总线通信,显示部分采用液晶模块,完成了系统实时控制、状态参数在线监测及命令数据传输等功能.实验结果表明,新型混合推进系统能够在不同模式工作下稳定工作,降低了燃油成本和污染,提高了系统

  15. Beam-pumping unit production breakdown automatic monitoring system design%游梁式抽油机生产故障自动监测系统设计

    Institute of Scientific and Technical Information of China (English)

    刘广友; 邵惠生; 董超群

    2014-01-01

    为了实时准确监测游梁式抽油机的生产运行状态,及时对停井及停电等故障进行排查和处理,研发了一套适用于油田生产现场的油井生产故障自动监测系统。系统采用接近开关检测曲柄销的运动状态,采用ACDC模块检测抽油机的供电状态,应用GSM网络将报警信息远传至上位机系统,通过页面开发和网络发布,实现了油井生产运行状态的在线实时监测。现场应用表面,系统停电报警响应时间小于20 s,停井报警响应时间小于60 s,且无误报漏报情况发生,满足现场实时性与准确性要求。%In order to monitor the beam-pumping unit production status accurately and process the breakdown or power failure in time, a production breakdown monitoring system for the beam-pumping unit is researched and developed. The proximity switch is adopted to detect the state of motion of the crank pin. The ACDC module is used to detect the state of power supply. The alarm information is transmitted to the upper computer by GSM network. The pages are developed and published. The online real-time monitoring of running status of the beam-pumping unit is realized. The application result shows that the response time of power failure is less than 20s, the response time of breakdown is less than 60s, and the system meets the real-time and accuracy requirements.

  16. Enlightenment of National Nutrition Monitoring Program in the United States on China%美国国家营养监测计划及对我国的启示

    Institute of Scientific and Technical Information of China (English)

    夏慧; 王宁; 彭亚拉

    2013-01-01

    公众的营养与健康状况是反映一个国家社会与经济发展、卫生健康水平和人口素质的重要指标,是国家制定营养相关政策的重要依据,因此,对全国居民展开营养监测必不可少.本文分析了美国相对完善的国家营养监测计划、对比了我国营养监测的现状,认为美国的营养监测计划在体制、执行和财政投入等方面对完善我国营养监测体系具有重要的借鉴价值.我国应尽快制定和完善适合本国国情的国家营养监测计划,提高其全面性、严密性、时效性及针对性,及时采取干预措施,指导人群健康膳食,保护公众的健康和安全.%The nutrition and health status of people is an important indicator for the economy and social development, health care level and the population diathesis of a country or region, and important basis for countries to develop nutrition-related policies. Therefore, it's essential to develop nutrition surveillance on residents. This article analyzed relatively perfect national nutrition monitoring program in the United States, and compared the current situation of China's nutrition monitoring. The nutrition monitoring program in the United States is a reference to China in system, executive and financial investment and so on. China should develop the national nutrition monitoring as soon as possible, improve its comprehensiveness, rigor, timeliness and relevance, take timely interventions, guide healthy diet, and protect the health and safety of the public.

  17. Le musée comme outil de remédiation identitaire : Le cas du Louvre-Lens

    Directory of Open Access Journals (Sweden)

    Maia Morel

    2015-02-01

    Full Text Available Depuis sa création, le musée a continûment développé ses ambitions et son action pédagogiques. S’il n’a plus aujourd’hui le rôle de glorification nationale qui a longtemps été le sien, sa fonction identitaire reste cependant entière. Le texte analyse sous cet angle l’implantation d’une antenne du Musée du Louvre à Lens, une région de France durement frappée par la crise industrielle, où existe une identité locale très forte, et qui connaît un phénomène de marginalisation. Symboliquement, le musée va à la rencontre des habitants en s’installant sur les lieux mêmes où se situait l’activité industrielle. Il leur propose d’autre part une vision extrêmement consensuelle de l’art, par la sélection qui est faite et par la légitimité que donne le Louvre aux œuvres exposées. La présentation est historique et va de l’Antiquité au début du XIX° siècle, c’est-à-dire à la Révolution industrielle. Le visiteur est ainsi invité à découvrir toute l’histoire de l’humanité vue à travers une vision nationale (donnée par le Louvre et à y rattacher sa propre histoire.

  18. Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations.

    Science.gov (United States)

    Grayson, Phil; Civetta, Alberto

    2013-09-30

    Sperm and testes-expressed Adam genes have been shown to undergo bouts of positive selection in mammals. Despite the pervasiveness of positive selection signals, it is unclear what has driven such selective bouts. The fact that only sperm surface Adam genes show signals of positive selection within their adhesion domain has led to speculation that selection might be driven by species-specific adaptations to fertilization or sperm competition. Alternatively, duplications and neofunctionalization of Adam sperm surface genes, particularly as it is now understood in rodents, might have contributed to an acceleration of evolutionary rates and possibly adaptive diversification. Here we sequenced and conducted tests of selection within the adhesion domain of sixteen known sperm-surface Adam genes among five species of the Mus genus. We find evidence of positive selection associated with all six Adam genes known to interact to form functional complexes on Mus sperm. A subset of these complex-forming sperm genes also displayed accelerated branch evolution with Adam5 evolving under positive selection. In contrast to our previous findings in primates, selective bouts within Mus sperm Adams showed no associations to proxies of sperm competition. Expanded phylogenetic analysis including sequence data from other placental mammals allowed us to uncover ancient and recent episodes of adaptive evolution. The prevailing signals of rapid divergence and positive selection detected within the adhesion domain of interacting sperm Adams is driven by duplications and potential neofunctionalizations that are in some cases ancient (Adams 2, 3 and 5) or more recent (Adams 1b, 4b and 6).

  19. Mathematical model of optimizing the arrival of fire units with the use of information systems for monitoring transport logistics of Voronezh city

    Directory of Open Access Journals (Sweden)

    A. V. Kochegarov

    2016-01-01

    Full Text Available In recent years, the strong pace of construction is increasing in big cities. With their growth becomes a question of the deployment of firefighters and the number of fire stations. The most effective solution is the problem of finding the optimum route of fire departments, taking into account the information transport logistics systems within the city that will allow us to arrive at the scene at any time, regardless of the degree of congestion of city roads. Prompt arrival of fire units provides the most successful fire fighting. The main objective of the study is to develop a preliminary route and the route in case of unforeseen factors affecting the time fire engine arrived. To construct the routes used to develop actively in the current methods of machine learning artificial neural networks. To construct the optimal route requires a correct prediction of the future behavior of a complex system of urban traffic based on its past behavior. Within the framework of statistical machine learning theory considered the problem of classification and regression. The learning process is to select a classification or a regression function of a predetermined broad class of such functions. After determining the prediction scheme, it is necessary to evaluate the quality of its forecasts, which are measured not on the basis of observations, and on the basis of an improved stochastic process, the result of the construction of the prediction rules. The model is verified on the basis of data collected in real departures real fire brigades, which made it possible to obtain a minimum time of arrival of fire units.

  20. Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleases.

    Directory of Open Access Journals (Sweden)

    Ana Agostinho

    Full Text Available Holliday junctions (HJs are cruciform DNA structures that are created during recombination events. It is a matter of considerable importance to determine the resolvase(s that promote resolution of these structures. We previously reported that C. elegans GEN-1 is a symmetrically cleaving HJ resolving enzyme required for recombinational repair, but we could not find an overt role in meiotic recombination. Here we identify C. elegans proteins involved in resolving meiotic HJs. We found no evidence for a redundant meiotic function of GEN-1. In contrast, we discovered two redundant HJ resolution pathways likely coordinated by the SLX-4 scaffold protein and also involving the HIM-6/BLM helicase. SLX-4 associates with the SLX-1, MUS-81 and XPF-1 nucleases and has been implicated in meiotic recombination in C. elegans. We found that C. elegans [mus-81; xpf-1], [slx-1; xpf-1], [mus-81; him-6] and [slx-1; him-6] double mutants showed a similar reduction in survival rates as slx-4. Analysis of meiotic diakinesis chromosomes revealed a distinct phenotype in these double mutants. Instead of wild-type bivalent chromosomes, pairs of "univalents" linked by chromatin bridges occur. These linkages depend on the conserved meiosis-specific transesterase SPO-11 and can be restored by ionizing radiation, suggesting that they represent unresolved meiotic HJs. This suggests the existence of two major resolvase activities, one provided by XPF-1 and HIM-6, the other by SLX-1 and MUS-81. In all double mutants crossover (CO recombination is reduced but not abolished, indicative of further redundancy in meiotic HJ resolution. Real time imaging revealed extensive chromatin bridges during the first meiotic division that appear to be eventually resolved in meiosis II, suggesting back-up resolution activities acting at or after anaphase I. We also show that in HJ resolution mutants, the restructuring of chromosome arms distal and proximal to the CO still occurs, suggesting that

  1. Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM) helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleases.

    Science.gov (United States)

    Agostinho, Ana; Meier, Bettina; Sonneville, Remi; Jagut, Marlène; Woglar, Alexander; Blow, Julian; Jantsch, Verena; Gartner, Anton

    2013-01-01

    Holliday junctions (HJs) are cruciform DNA structures that are created during recombination events. It is a matter of considerable importance to determine the resolvase(s) that promote resolution of these structures. We previously reported that C. elegans GEN-1 is a symmetrically cleaving HJ resolving enzyme required for recombinational repair, but we could not find an overt role in meiotic recombination. Here we identify C. elegans proteins involved in resolving meiotic HJs. We found no evidence for a redundant meiotic function of GEN-1. In contrast, we discovered two redundant HJ resolution pathways likely coordinated by the SLX-4 scaffold protein and also involving the HIM-6/BLM helicase. SLX-4 associates with the SLX-1, MUS-81 and XPF-1 nucleases and has been implicated in meiotic recombination in C. elegans. We found that C. elegans [mus-81; xpf-1], [slx-1; xpf-1], [mus-81; him-6] and [slx-1; him-6] double mutants showed a similar reduction in survival rates as slx-4. Analysis of meiotic diakinesis chromosomes revealed a distinct phenotype in these double mutants. Instead of wild-type bivalent chromosomes, pairs of "univalents" linked by chromatin bridges occur. These linkages depend on the conserved meiosis-specific transesterase SPO-11 and can be restored by ionizing radiation, suggesting that they represent unresolved meiotic HJs. This suggests the existence of two major resolvase activities, one provided by XPF-1 and HIM-6, the other by SLX-1 and MUS-81. In all double mutants crossover (CO) recombination is reduced but not abolished, indicative of further redundancy in meiotic HJ resolution. Real time imaging revealed extensive chromatin bridges during the first meiotic division that appear to be eventually resolved in meiosis II, suggesting back-up resolution activities acting at or after anaphase I. We also show that in HJ resolution mutants, the restructuring of chromosome arms distal and proximal to the CO still occurs, suggesting that CO initiation

  2. Deep-sea crustacean trawling fisheries in Portugal: quantification of effort and assessment of landings per unit effort using a Vessel Monitoring System (VMS)

    Science.gov (United States)

    Bueno-Pardo, Juan; Ramalho, Sofia P.; García-Alegre, Ana; Morgado, Mariana; Vieira, Rui P.; Cunha, Marina R.; Queiroga, Henrique

    2017-01-01

    Mapping and quantifying bottom trawling fishing pressure on the seafloor is pivotal to understand its effects on deep-sea benthic habitats. Using data from the Vessel Monitoring System of crustacean trawlers along the Portuguese margin, we have identified the most exploited areas and characterized the most targeted habitats and water depths. We estimated a total trawling effort of 69596, 66766, and 63427 h y‑1 for the years 2012, 2013, and 2014 respectively which, considering the total landings estimated for this gear, yield values of 20.76, 21.06, and 19.11 kg of landed fish per trawled hour. The main trawling pressure is exerted in the South and Southwest Portuguese margins, on muddy and muddy-sand bottoms between 200 and 700 m water depths, while in the North and Central-West coasts a minor effort, at shallower waters and across a wider range of habitats, is also applied. The most landed species are crustaceans such as rose shrimp and Norway lobster, although this varies importantly between the different regions of Portugal, being fish and cephalopods the main captures in the Northern ports. We discuss the consequences of trawling for the impacted communities as well as the characteristics of the commercialization of these captures in Portugal.

  3. Deep-sea crustacean trawling fisheries in Portugal: quantification of effort and assessment of landings per unit effort using a Vessel Monitoring System (VMS)

    Science.gov (United States)

    Bueno-Pardo, Juan; Ramalho, Sofia P.; García-Alegre, Ana; Morgado, Mariana; Vieira, Rui P.; Cunha, Marina R.; Queiroga, Henrique

    2017-01-01

    Mapping and quantifying bottom trawling fishing pressure on the seafloor is pivotal to understand its effects on deep-sea benthic habitats. Using data from the Vessel Monitoring System of crustacean trawlers along the Portuguese margin, we have identified the most exploited areas and characterized the most targeted habitats and water depths. We estimated a total trawling effort of 69596, 66766, and 63427 h y−1 for the years 2012, 2013, and 2014 respectively which, considering the total landings estimated for this gear, yield values of 20.76, 21.06, and 19.11 kg of landed fish per trawled hour. The main trawling pressure is exerted in the South and Southwest Portuguese margins, on muddy and muddy-sand bottoms between 200 and 700 m water depths, while in the North and Central-West coasts a minor effort, at shallower waters and across a wider range of habitats, is also applied. The most landed species are crustaceans such as rose shrimp and Norway lobster, although this varies importantly between the different regions of Portugal, being fish and cephalopods the main captures in the Northern ports. We discuss the consequences of trawling for the impacted communities as well as the characteristics of the commercialization of these captures in Portugal. PMID:28098211

  4. Software Communication between WinCC Software and Bently Unit Status Monitoring System%本特利机组状态监控系统与WinCC的通信方法

    Institute of Scientific and Technical Information of China (English)

    安富平

    2012-01-01

    The communication between Bently unit status monitoring system and HMI software of the host computer was discussed; and through the function of network communication of Windows DDE and DDE Server from Bently Data Acquisition software, the data were successfully transmitted to WinCC.%围绕本特利公司机组状态监控系统实现与上位计算机HMI软件通信的方法进行论述.利用Windows DDE的网络通信功能和本特利公司Data Acquisition软件提供的DDE server功能,成功地将数据传精到WinCC监控软件包中.

  5. Results of a monitoring program of continuous water levels and physical water properties at the Operable Unit 1 area of the Savage Municipal Well Superfund site, Milford, New Hampshire, water years 2000-03

    Science.gov (United States)

    Harte, Philip T.

    2005-01-01

    The Milford-Souhegan glacial-drift (MSGD) aquifer, in south-central New Hampshire, is an important source of industrial, commercial, and domestic water. The MSGD aquifer was also an important source of drinking water for the town of Milford until it was found to contain high concentrations of volatile organic compounds (VOCs) in the Savage and Keyes municipal-supply wells in the early 1980s. A VOC plume was found to cover part of the southwestern half of the MSGD aquifer. In September 1984, the site was designated a Superfund site, called the Savage Municipal Well Superfund site. The primary source area of contaminants was a former tool manufacturing facility (called the OK Tool facility, and now called the Operable Unit 1 (OU1) area) that disposed of solvents at the surface and in the subsurface. The facility was closed in 1987 and removed in 1998. A low-permeability containment barrier wall was constructed and installed in the overburden (MSGD aquifer) in 1998 to encapsulate the highest concentrations of VOCs, and a pump-and-treat remediation facility was also added. Remedial operations of extraction and injection wells started in May 1999. A network of water-level monitoring sites was implemented in water year 2000 (October 1, 1999, through September 30, 2000) in the OU1 area to help assess the effectiveness of remedial operations to mitigate the VOC plume, and to evaluate the effect of the barrier wall and remedial operations on the hydraulic connections across the barrier and between the overburden and underlying bedrock. Remedial extraction and injections wells inside and outside the barrier help isolate ground-water flow inside the barrier and the further spreading of VOCs. This report summarizes both continuous and selected periodic manual measurements of water level and physical water properties (specific conductance and water temperature) for 10 monitoring locations during water years 2000-03. Additional periodic manual measurements of water levels were

  6. Monitoring Colonias Development along the United States-Mexico Border: A Process Application using GIS and Remote Sensing in Douglas, Arizona, and Agua Prieta, Sonora

    Science.gov (United States)

    Norman, Laura M.; Donelson, Angela J.; Pfeifer, Edwin L.; Lam, Alven H.; Osborn, Kenneth J.

    2004-01-01

    The U.S. Department of Housing and Urban Development (HUD) and the U.S. Geological Survey (USGS) have developed a joint project to create Internet-enabled geographic information systems (GIS) that will help cities along the United States-Mexico border deal with issues related to colonias. HUD defines colonias as rural neighborhoods in the United States-Mexico border region that lack adequate infrastructure or housing and other basic services. They typically have high poverty rates that make it difficult for residents to pay for roads, sanitary water and sewer systems, decent housing, street lighting, and other services through assessment. Many Federal agencies recognize colonias designations and provide funding assistance. It is the intention of this project to empower Arizona-Sonora borderland neighborhoods and community members by recognizing them as colonias. This recognition will result in eligibility for available economic subsidies and accessibility to geospatial tools and information for urban planning. The steps to achieve this goal include delineation of colonia-like neighborhoods, identification of their urbanization over time, development of geospatial databases describing their infrastructure, and establishment of a framework for distributing Web-based GIS decision support systems. A combination of imagery and infrastructure information was used to help delineate colonia boundaries. A land-use change analysis, focused on urbanization in the cities over a 30-year timeframe, was implemented. The results of this project are being served over the Internet, providing data to the public as well as to participating agencies. One of the initial study areas for this project was the City of Douglas, Ariz., and its Mexican sister-city Agua Prieta, Sonora, which are described herein. Because of its location on the border, this twin-cities area is especially well suited to international manufacturing and commerce, which has, in turn, led to an uncontrolled spread of

  7. 基于电力线工频通信的抽油机电机远程监测研究%Power Line TWACS-Based Remote Monitoring of Electric Machines for Pumping Units

    Institute of Scientific and Technical Information of China (English)

    李卫国; 卢文冰; 罗应立; 邱宇峰

    2012-01-01

    针对油井位置分散、管理困难的现状,设计了基于电力线工频通信的抽油机电机远程监测系统.除了传统的电气参数外,采用Morlet复小波方法计算电机运行冲程内连续变化的电流基波幅值及相位,为抽油机本体的运行和故障判断提供信息.在监测数据传输方面,传统的工频通信方式以本地电压过零为基准,通过时域差分实现解调,在油田电网噪声干扰强,变电所与各配电变压器低压侧由于各种因素存在工频电压过零时差的环境中,难以进行同步检测,同时存在接收时域偏差而影响通信性能.为此,基于伪随机编码进行前导信息的调制,然后通过信号合成和时频分析确定数据编码的起始时刻和信号的调制时域,这样能够在油田电网恶劣的环境中进行同步检测,并且通过克服信号收发端电压相位差的影响而大大提高数据解调的质量.根据文中方法研制的远程监测系统已经在油田电网进行规模化试验运行,在低成本条件下实现了对抽油机电机的远程监测、管理.%In allusion to management difficulty of oil wells due to their dispersed locations, based on power line two-way automatic communication system (TWACS) a remote monitoring system of electric machines for oil wells is developed. In addition to traditional electrical parameters, the continually varying amplitude and phase of fundamental current within the stroke of electric machine are calculated by Morlet complex wavelet method to provide information of the operation and fault judgment for pumping units themselves. In view of strong noise interferences in oil field and time differences of zero-crossing points among low voltage sides of distribution transformers in substations caused by various factors it is difficult to perform synchronous monitoring and due to the deviation of receiving time-domain the performance of communication is affected, thus it is difficult to transmit

  8. Annual Post-Closure Inspection and Monitoring Report for Corrective Action Unit 329: Area 22 Desert Rock Airstrip Fuel Spill, Nevada Test Site, Nevada, with Errata Sheet, Rev. No.: 1

    Energy Technology Data Exchange (ETDEWEB)

    Wickline, Alfred

    2007-01-01

    This report presents the data collected during field activities and quarterly soil-gas sampling activities conducted from May 9, 2005, through May 20, 2006, at Corrective Action Unit (CAU) 329, Area 22 Desert Rock Airstrip (DRA) Fuel Spill; Corrective Action Site (CAS) 22-44-01, Fuel Spill. The CAU is located at the DRA, which is located approximately two miles southwest of Mercury, Nevada. A risk evaluation was added to the scope of the project to determine if the residual concentration of the hazardous constituents of JP4 pose an unacceptable risk to human health or the environment and if a corrective action was required at the site, because the current quarterly monitoring program is not expected to yield a rate constant that could be used effectively to determine a biodegradation rate for total petroleum hydrocarbons (TPH) in less than the initial five years outlined in the CR. Additionally, remediation to the Tier 1 action level for TPH is not practical or technically feasible due to the depth of contamination. Field activities were conducted under the Addendum to the CR to collect sufficient data to determine the rate of biodegradation for TPH contamination at CAU 329 to support closure requirements. Reconstruction of the monitoring system at the site and quarterly soil-gas sampling were conducted to collect the required data. Because existing Wells DRA-0 and DRA-3 were determined to be insufficient to provide adequate data, soil-gas monitoring Wells DRA-10 and DRA-11 were installed. Two soil-gas sampling events were conducted to establish a baseline for the site, and subsequent quarterly sampling was conducted as part of the quarterly soil-gas sampling program. In addition, soil samples were collected during well drilling activities so comparisons might be made between the initial soil contamination levels in 2000 and the concentrations present at the time of the well installation.

  9. Réappropriation du patrimoine autochtone : défis et nouvelles pratiques muséales et archivistiques

    Directory of Open Access Journals (Sweden)

    Melissa Vernier

    2016-12-01

    Full Text Available Le rapport de la Commission de vérité et réconciliation du Canada (2015 fait le point sur la colonisation et les politiques du gouvernement fédéral ayant porté atteinte à l’identité culturelle des peuples autochtones du pays. Que cela ait été intentionnel ou non, les institutions de la mémoire – musées, centres d’archives et bibliothèques – ont contribué à cet héritage colonial par l’imposition d’un régime d’historicité de conservation et d’interprétation occidental. Le mouvement pour la réappropriation du patrimoine culturel autochtone, mené tant par les groupes autochtones que par les institutions de la mémoire elles-mêmes, cherche à corriger cette situation par des mesures aussi variées que le rapatriement, la restitution, la gestion partagée et l’autogestion des collections autochtones ainsi que la création de partenariats et de projets collaboratifs. Cette étude analyse d’abord le contexte sociohistorique dans lequel évolue le mouvement pour la réappropriation du patrimoine culturel autochtone pour ensuite présenter les réformes et les pratiques exemplaires des institutions de la mémoire issues de ce mouvement. Ces réformes témoignent de deux tendances distinctes, soit des stratégies d’autonomisation ou de collaboration. L’étude conclut sur quelques recommandations quant aux mesures institutionnelles à privilégier pour les prochaines décennies. The Truth and Reconciliation Commission of Canada’s Report (2015 takes stock of colonization and federal government policies that adversely affect the cultural identity of the country’s Indigenous People. Intentionally or not, memory institutions – museums, archives and libraries – have contributed this to the colonial heritage by imposing a regime of conservation historicity and Western interpretation. The movement to reclaim Indigenous People’s cultural heritage, led by both indigenous groups and memory institutions, seeks to

  10. Syphacia obvelata (Nematode, Oxyuridae) infecting laboratory mice Mus musculus (Rodentia, Muridae): phylogeny and host-parasite relationship.

    Science.gov (United States)

    Abdel-Gaber, Rewaida

    2016-03-01

    Syphacia obvelata is a pinworm nematode parasite infecting man and laboratory animals in high abundance. This parasitological study was carried out during the period of March 2014-February 2015 to investigate the helminth parasites infecting the laboratory mice Mus musculus in the Animal House at Cairo University, Egypt. The prevalence of S. obvelata in M. musculus was 75.0 %. The extent of infection with S. obvelata is analyzed according to the sex of the host mice. It was shown that the prevalence of male infection was greater than female worms. Morphological characterization revealed that the present Oxyurid species possesses a rounded cephalic end with less developed lips, esophagus divided into cylindrical corpus, and globular bulb supported internally with valvular apparatus; three mamelons are located at the ventral surface with a single chitinized spicule and a gubernaculum provided with an accessory hook in males, and ovijector apparatus opens ventrally by the vulva surrounded by protruded lips in female worms. Body of the male was 0.623-1.130 (0.830 ± 0.11) mm long and 0.092-0.130 (0.110 ± 0.01) mm wide; the esophagus was 0.164-0.280 (0.210 ± 0.01) mm long; the nerve ring and excretory pore are located at 0.035-0.132 (0.073 ± 0.01) and 0.087-0.191 (0.145 ± 0.01) mm from the anterior end, respectively, while the female measured 2.930-4.650 (3.540 ± 0.1) mm long and 0.120-0.232 (0.156 ± 0.001) mm wide; the esophagus was 0.213-0.410 (0.342 ± 0.01) mm long; the nerve ring, excretory pore, and vulval opening are located at 0.026-0.157 (0.121 ± 0.01), 0.134-0.243 (0.195 ± 0.01), and 0.323-0.632 (0.546 ± 0.11) mm from the anterior end, respectively; eggs measured 0.120-0.139 (0.129 ± 0.001) mm long and 0.030-0.052 (0.045 ± 0.001) mm wide. It compared morphometrically with other Syphacia species described previously and showed little differences in

  11. Monitorización de úlceras por presión en una Unidad de cuidados intensivos Monitorization of pressure ulcers in a critical care Unit

    Directory of Open Access Journals (Sweden)

    José A. Esperón Güimil

    2007-09-01

    Full Text Available Introducción: Las úlceras por presión (UPP son un indicador de mala calidad asistencial. Los pacientes ingresados en Unidades de cuidados intensivos presentan gran número de factores de riesgo de padecer UPP, siendo de las Unidades con mayores índices de incidencia. Objetivos: Determinar la prevalencia de UPP y el paciente tipo que desarrolla UPP. Material y métodos: Estudio prospectivo de prevalencia. Variables dependientes: nº de UPP (nº de UPP excluyendo las iatrogénicas; nº de UPPY (nº de UPP iatrogénicas y nº de UPPT (nº de UPP + nº de UPPY. Variables independientes: sexo, edad, diagnóstico, riesgo Nova 4, estadios, índice de severidad, localizaciones, fechas de registro de las UPP, medidas preventivas. Análisis: Paquete estadístico G-Stat 2.0. Descriptivo: media y desviación estándar; frecuencias relativas y absolutas. Inferencial: T-Student, ANOVA, modelo de regresión lineal. Significación estadística de pIntroduction: Pressure ulcers (PU are an indicator of poor assistance quality. Patients in units of intensive care present a considerable number of risk factors of suffering UPP, in fact, these units are among with a higher of incidence of PUs. Objectives: To determine the prevalence of PUs and the type of patient who develops PUs. Material and methods: Prospective study of prevalence. Dependent variables: no. of PUs (no. of PUs, excluding iatrogenic ones; no. of IPUs (no. of iatrogenic PU and no. of TPUs (no. of PUs + no. of IPUs. Independent variables: sex, age, diagnostic, risk Nova 4, stadiums, Index of severity, localizations, dates of registration of the UPP, preventive measures. Analysis: statistical package G-Stat 2.0.Descriptive:mean and standard desviation; relative and absolute frequencies. Inferential: T-Student, ANOVA, linear regression model. Statistical significance: p< 0,05; IC 95%. Results: PUs prevalenc: 12,7%; IPUs prevalence: 6,8%. 142 PUs registered, 45 of them of iatrogenic origin. More

  12. Post-Closure Inspection and Monitoring Report for Corrective Action Unit 417: Central Nevada Test Area Surface, Hot Creek Valley, Nevada For Calendar Year 2006

    Energy Technology Data Exchange (ETDEWEB)

    None

    2007-06-01

    Corrective Action Unit (CAU) 417, Central Nevada Test Area - Surface, is located in Hot Creek Valley in northern Nye County, Nevada, and consists of three areas commonly referred to as UC-1, UC-3, and UC-4. CAU 417 consists of 34 Corrective Action Sites (CASs) which were closed in 2000 (U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office, 2001). Three CASs at UC-1 were closed in place with administrative controls. At CAS 58-09-01, Central Mud Pit (CMP), a vegetated soil cover was constructed over the mud pit. At the remaining two sites, CAS 58-09-02, Mud Pit, and CAS 58-09-05, Mud Pits (3), aboveground monuments and warning signs were installed to mark the CAS boundaries. Three CASs at UC-3 were closed in place with administrative controls. Aboveground monuments and warning signs were installed to mark the site boundaries at CAS 58-09-06, Mud Pits (5), CAS 58-25-01, Spill, and CAS 58-10-01, Shaker Pad Area. Two CASs that consist of five sites at UC-4 were closed in place with administrative controls. At CAS 58-09-03, Mud Pits (5), an engineered soil cover was constructed over Mud Pit C. At the remaining three sites in CAS 58-09-03 and at CAS 58-10-05, Shaker Pad Area, aboveground monuments and warning signs were installed to mark the site boundaries. The remaining 26 CASs at CAU 417 were either clean-closed or closed by taking no further action.

  13. Using Search Query Surveillance to Monitor Tax Avoidance and Smoking Cessation following the United States' 2009 “SCHIP” Cigarette Tax Increase

    Science.gov (United States)

    Ayers, John W.; Ribisl, Kurt; Brownstein, John S.

    2011-01-01

    Smokers can use the web to continue or quit their habit. Online vendors sell reduced or tax-free cigarettes lowering smoking costs, while health advocates use the web to promote cessation. We examined how smokers' tax avoidance and smoking cessation Internet search queries were motivated by the United States' (US) 2009 State Children's Health Insurance Program (SCHIP) federal cigarette excise tax increase and two other state specific tax increases. Google keyword searches among residents in a taxed geography (US or US state) were compared to an untaxed geography (Canada) for two years around each tax increase. Search data were normalized to a relative search volume (RSV) scale, where the highest search proportion was labeled 100 with lesser proportions scaled by how they relatively compared to the highest proportion. Changes in RSV were estimated by comparing means during and after the tax increase to means before the tax increase, across taxed and untaxed geographies. The SCHIP tax was associated with an 11.8% (95% confidence interval [95%CI], 5.7 to 17.9; ptax levels in Canada during the months after the tax. Tax avoidance searches increased 27.9% (95%CI, 15.9 to 39.9; ptax compared to Canada, respectively, suggesting avoidance is the more pronounced and durable response. Trends were similar for state-specific tax increases but suggest strong interactive processes across taxes. When the SCHIP tax followed Florida's tax, versus not, it promoted more cessation and avoidance searches. Efforts to combat tax avoidance and increase cessation may be enhanced by using interventions targeted and tailored to smokers' searches. Search query surveillance is a valuable real-time, free and public method, that may be generalized to other behavioral, biological, informational or psychological outcomes manifested online. PMID:21436883

  14. Spatio-temporal trends and monitoring design of perfluoroalkyl acids in the eggs of gull (Larid) species from across Canada and parts of the United States.

    Science.gov (United States)

    Gewurtz, Sarah B; Martin, Pamela A; Letcher, Robert J; Burgess, Neil M; Champoux, Louise; Elliott, John E; Weseloh, D V Chip

    2016-09-15

    A large spatial dataset of perfluoroalkyl acid (PFAA) concentrations in eggs of herring gulls (Larus argentatus or congeneric species) collected from late April to early June between 2009 and 2014 from 28 colonies across Canada and parts of the Unites States was used to evaluate location-specific patterns in chemical concentrations and to generate hypotheses on the major sources affecting PFAA distributions. The highly bioaccumulative perfluorooctane sulfonic acid (PFOS) as well as other perfluoroalkyl sulfonic acids (PFSAs) showed the greatest concentrations in eggs from the lower Great Lakes of southern Ontario as well as from the St. Lawrence River. Despite the 2000 to 2002 phase-out of PFOS and related C8 chemistry by the major manufacturer at the time, ongoing losses from consumer products during use and disposal in urban/industrial locations continue to be major sources to the environment and are influencing the spatial trends of PFOS in Canada. In comparison to PFOS, perfluoroalkyl carboxylic acids (PFCAs) were not as concentrated in eggs in close proximity to urbanized/industrialized centers, but had surprisingly elevated levels in relatively remote regions such as Great Slave Lake, NT and East Bay in Hudson Bay, NU. The present results support the hypothesis that atmospheric transport and degradation of precursor chemicals, such as the fluorotelomer alcohols 8:2 FTOH and 10:2 FTOH, are influencing the spatial trends of PFCAs in Canada. A power analysis conducted on a representative urbanized/industrialized colony in the Toronto Harbour, ON, and a relatively remote colony in Lake Superior, emphasized the importance of consistent and long-term data collection in order to detect the anticipated changes in PFAA concentrations in Canadian gull eggs. Crown Copyright © 2016. Published by Elsevier B.V. All rights reserved.

  15. 上海市嘉定区集体单位流感样病例监测分析%Monitoring and analysis on influenza -like illness in collective units in Jiading District of Shanghai City

    Institute of Scientific and Technical Information of China (English)

    陈冬华; 钱杰; 姜欣志; 张涛; 沈永; 张欣; 朱也凡; 钟培松

    2012-01-01

    Objective To understand the prevalence tendency of influenza like illness (ILI) in schools, kindergartens , geracomiums and other collective units in Jiading District, promptly find the influenza aggregation or epidemics, and provide scientific basis for marking and improving influenza monitoring system. Method Descriptively analyze the monitoring data of ILI from 94 schools, 64 kindergartens and 24 geracomiums from September, 2009 to March, 2010. Results Schools reported that ILI was stable at a high level between the 37th week and 40th week, and then dropped drastically. Then it slowly increased to the peak at the 47th week, fell to zero at the 4th week of the next year, and at last slowly rose at the 6th week. The prevalence of ILI in kindergartens was basically consistent with that in schools, but the peak time delayed about 2 weeks. No ILI was reported in geracomiums. Conclusion Syndromic monitoring in collective units could timely detect the outbreak of influenza and help control the epidemic situation in the bud.%目的 了解嘉定区学校、幼托机构、养老院等集体单位流感样病例(ILI)流行趋势,及时发现流感聚集性/暴发疫情,为制订和完善流感监测系统提供科学依据.方法 描述性分析94家学校、64家托幼机构和24家养老机构在2009年9月~ 2010年3月ILI监测数据.结果 学校报告ILI在37 ~40周平稳在较高水平,而后出现骤降,随后缓慢增加,至47周达峰值,紧接着又不断下降,到次年4周为0,6周出现缓慢回升;托幼机构ILI流行趋势与学校基本一致,但峰值出现时间较学校推迟2周左右;养老机构无ILI报告.结论 集体单位症状监测能及时发现流感暴发苗子,有助于将疫情控制在萌芽状态.

  16. Novel arenavirus sequences in Hylomyscus sp. and Mus (Nannomys) setulosus from Côte d'Ivoire: implications for evolution of arenaviruses in Africa.

    Science.gov (United States)

    Coulibaly-N'Golo, David; Allali, Bernard; Kouassi, Stéphane K; Fichet-Calvet, Elisabeth; Becker-Ziaja, Beate; Rieger, Toni; Olschläger, Stephan; Dosso, Hernri; Denys, Christiane; Ter Meulen, Jan; Akoua-Koffi, Chantal; Günther, Stephan

    2011-01-01

    This study aimed to identify new arenaviruses and gather insights in the evolution of arenaviruses in Africa. During 2003 through 2005, 1,228 small mammals representing 14 different genera were trapped in 9 villages in south, east, and middle west of Côte d'Ivoire. Specimens were screened by pan-Old World arenavirus RT-PCRs targeting S and L RNA segments as well as immunofluorescence assay. Sequences of two novel tentative species of the family Arenaviridae, Menekre and Gbagroube virus, were detected in Hylomyscus sp. and Mus (Nannomys) setulosus, respectively. Arenavirus infection of Mus (Nannomys) setulosus was also demonstrated by serological testing. Lassa virus was not found, although 60% of the captured animals were Mastomys natalensis. Complete S RNA and partial L RNA sequences of the novel viruses were recovered from the rodent specimens and subjected to phylogenetic analysis. Gbagroube virus is a closely related sister taxon of Lassa virus, while Menekre virus clusters with the Ippy/Mobala/Mopeia virus complex. Reconstruction of possible virus-host co-phylogeny scenarios suggests that, within the African continent, signatures of co-evolution might have been obliterated by multiple host-switching events.

  17. Transformative Poetry. A Case Study of W. H. Auden’s Musée Des Beaux Arts and General Conclusions

    Directory of Open Access Journals (Sweden)

    Sarot Marcel

    2016-10-01

    Full Text Available This article situates Auden’s poem Musée des Beaux Arts in the process of his conversion to Christianity. The author argues for the layered intertextuality of the poem, in which allusions to Bruegel’s Landscape with the Fall of Icarus, The Census at Jerusalem, and The Massacre of the Innocents can be recognised. Moreover, Philippe de Champaigne’s Presentation in the Temple and Peter Paul Rubens’s The Martyrdom of St Livinus (in the same museum in Brussels seem also to have influenced the poem. Finally, there is reason to suppose that John Singer Sargent’s Crashed Aeroplane influenced Auden. In an analysis of the structure of the poem, the author argues that there is a clear structure hidden under the surface of day-to-day language. He connects this hidden structure with Auden’s poem The Hidden Law, and suggests that Auden wished to claim that even though we cannot understand suffering, it has a hidden meaning known only to God. This hidden meaning connects our suffering with the self-emptying of Christ, a connection which the author demonstrates is in fact also made in Musée des Beaux Arts.

  18. Novel arenavirus sequences in Hylomyscus sp. and Mus (Nannomys setulosus from Cote d'Ivoire: implications for evolution of arenaviruses in Africa.

    Directory of Open Access Journals (Sweden)

    David Coulibaly-N'Golo

    Full Text Available This study aimed to identify new arenaviruses and gather insights in the evolution of arenaviruses in Africa. During 2003 through 2005, 1,228 small mammals representing 14 different genera were trapped in 9 villages in south, east, and middle west of Côte d'Ivoire. Specimens were screened by pan-Old World arenavirus RT-PCRs targeting S and L RNA segments as well as immunofluorescence assay. Sequences of two novel tentative species of the family Arenaviridae, Menekre and Gbagroube virus, were detected in Hylomyscus sp. and Mus (Nannomys setulosus, respectively. Arenavirus infection of Mus (Nannomys setulosus was also demonstrated by serological testing. Lassa virus was not found, although 60% of the captured animals were Mastomys natalensis. Complete S RNA and partial L RNA sequences of the novel viruses were recovered from the rodent specimens and subjected to phylogenetic analysis. Gbagroube virus is a closely related sister taxon of Lassa virus, while Menekre virus clusters with the Ippy/Mobala/Mopeia virus complex. Reconstruction of possible virus-host co-phylogeny scenarios suggests that, within the African continent, signatures of co-evolution might have been obliterated by multiple host-switching events.

  19. Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions.

    Science.gov (United States)

    Garner, Elizabeth; Kim, Yonghwan; Lach, Francis P; Kottemann, Molly C; Smogorzewska, Agata

    2013-10-17

    Holliday junctions (HJs), the DNA intermediates of homologous recombination, need to be faithfully processed in order to preserve genome integrity. In human cells, the BLM helicase complex promotes nonnucleolytic dissolution of double HJs. In vitro, HJs may be nucleolytically processed by MUS81-EME1, GEN1, and SLX4-SLX1. Here, we exploit human SLX4-null cells to examine the requirements for HJ resolution in vivo. Lack of BLM and SLX4 or GEN1 and SLX4 is synthetically lethal in the absence of exogenous DNA damage, and lethality is a consequence of dysfunctional mitosis proceeding in the presence of unprocessed HJs. Thus, GEN1 activity cannot be substituted for the SLX4-associated nucleases, and one of the HJ resolvase activities, either of those associated with SLX4 or with GEN1, is required for cell viability, even in the presence of BLM. In vivo HJ resolution depends on both SLX4-associated MUS81-EME1 and SLX1, suggesting that they are acting in concert in the context of SLX4. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

  20. Human GEN1 and the SLX4-Associated Nucleases MUS81 and SLX1 Are Essential for the Resolution of Replication-Induced Holliday Junctions

    Directory of Open Access Journals (Sweden)

    Elizabeth Garner

    2013-10-01

    Full Text Available Holliday junctions (HJs, the DNA intermediates of homologous recombination, need to be faithfully processed in order to preserve genome integrity. In human cells, the BLM helicase complex promotes nonnucleolytic dissolution of double HJs. In vitro, HJs may be nucleolytically processed by MUS81-EME1, GEN1, and SLX4-SLX1. Here, we exploit human SLX4-null cells to examine the requirements for HJ resolution in vivo. Lack of BLM and SLX4 or GEN1 and SLX4 is synthetically lethal in the absence of exogenous DNA damage, and lethality is a consequence of dysfunctional mitosis proceeding in the presence of unprocessed HJs. Thus, GEN1 activity cannot be substituted for the SLX4-associated nucleases, and one of the HJ resolvase activities, either of those associated with SLX4 or with GEN1, is required for cell viability, even in the presence of BLM. In vivo HJ resolution depends on both SLX4-associated MUS81-EME1 and SLX1, suggesting that they are acting in concert in the context of SLX4.

  1. Whole Genome Sequence of Two Wild-Derived Mus musculus domesticus Inbred Strains, LEWES/EiJ and ZALENDE/EiJ, with Different Diploid Numbers

    Directory of Open Access Journals (Sweden)

    Andrew P. Morgan

    2016-12-01

    Full Text Available Wild-derived mouse inbred strains are becoming increasingly popular for complex traits analysis, evolutionary studies, and systems genetics. Here, we report the whole-genome sequencing of two wild-derived mouse inbred strains, LEWES/EiJ and ZALENDE/EiJ, of Mus musculus domesticus origin. These two inbred strains were selected based on their geographic origin, karyotype, and use in ongoing research. We generated 14× and 18× coverage sequence, respectively, and discovered over 1.1 million novel variants, most of which are private to one of these strains. This report expands the number of wild-derived inbred genomes in the Mus genus from six to eight. The sequence variation can be accessed via an online query tool; variant calls (VCF format and alignments (BAM format are available for download from a dedicated ftp site. Finally, the sequencing data have also been stored in a lossless, compressed, and indexed format using the multi-string Burrows-Wheeler transform. All data can be used without restriction.

  2. Toxicological Evaluation of Essential Oil From the Leaves of Croton argyrophyllus (Euphorbiaceae) on Aedes aegypti (Diptera: Culicidae) and Mus musculus (Rodentia: Muridae).

    Science.gov (United States)

    Cruz, R C D; Silva, S L C E; Souza, I A; Gualberto, S A; Carvalho, K S; Santos, F R; Carvalho, M G

    2017-01-27

    Plant-derived essential oils can be used as insecticides for vector control. However, to establish their safety, it is necessary to perform toxicological studies. Herein, we evaluated the chemical composition and insecticidal activity of the essential oil from the leaves of Croton argyrophyllus on the third- and fourth-instar larvae and adult Aedes aegypti (L., 1762). We also evaluated the acute toxicity of the essential oil in adult female Mus musculus The lethal concentration 50 (LC50) and 90 (LC90) of C. argyrophyllus essential oil on larvae of Ae. aegypti were 0.31 and 0.70 mg ml(-1), respectively, and 5.92 and 8.94 mg ml(-1), respectively, on Ae. aegypti adults. The major components of the essential oil were spathulenol (22.80%), (E)-caryophyllene (15.41%), α-pinene (14.07%), and bicyclogermacrene (10.43%). It also displayed acute toxicity in adults of Mus musculus; the intraperitoneal and oral lethal dose 50 (LD50) were 2,000 mg kg(-1) and 2,500 mg kg(-1), respectively. The results showed that the essential oil from C. argyrophyllus leaves has insecticidal activity on Ae. aegypti larvae and adults at an average lethal concentration below the median lethal dose needed to cause acute toxicity in the common mouse.

  3. PENGARUH TRITERPEN TOTAL PEGAGAN (Centella asiatica (L Urban TERHADAP FUNGSI KOGNITIF BELAJAR DAN MENGINGAT PADA MENCIT JANTAN ALBINO (Mus musculus YANG DIHAMBAT DENGAN SKOPOLAMIN

    Directory of Open Access Journals (Sweden)

    Herlina

    2010-11-01

    Full Text Available Pegagan (Centella asiatica (L Urban has been described to posses CNS effects such as improving cognitive function, learning and memory. The aim of the research was to evaluate the effects of total triterpen’s pegagan extract on cognitive functions as the learning and memory performance in male albino mice (Mus musculus inhibited by scopolamine. The research design was Complete Randomized Design (RAL – factorial on thirty six mice divided into 4 groups. One control group received only aquabidest (negative control. Three treatment groups received total triterpen 16 mg/kg BW, 32 mg/kg BW orally and piracetam 500 mg/kg BW by intra peritoneally (positive control for 21 days. Data indicating learning and memory process of all subjects were obtained from one-trial passive avoidance test. Data were analyzed by two way ANOVA and BNT (p0,05. In conclusion, total triterpen from pegagan (Centella asiatica (L Urban improved learning ability and memory of male albino mice (Mus musculus even though, it was inhibited by scopolamine.

  4. Bed Unit Disinfection Machine with Real-time Monitoring and Control Functions of Ozone Concentration%可实时监控臭氧浓度的床单位消毒机

    Institute of Scientific and Technical Information of China (English)

    杨震; 杨树欣; 高磊; 陈爱华; 詹宁波; 田林怀

    2014-01-01

    目的:研制一种床单位臭氧消毒机,提高床单位的杀菌效果。方法设计一种能实时在线检测臭氧浓度的检测系统,并通过89C51单片机控制供给臭氧发生器的电压,实现整个臭氧生产过程的闭环控制。结果消毒机具备臭氧浓度的实时监测和控制功能,使床罩内臭氧浓度保持最佳杀菌效果。结论该床单位臭氧消毒机利用臭氧熏蒸消毒,对多种细菌繁殖体和真菌都有较好的杀灭作用,对床单位实际消毒效果能达到规范的要求。%Objective To improve sterilization effect of bed unit by studying a bed unit ozone disinfection machine. Methods Having the voltage supplied to ozone generator by 89C51 chip, a measurement and control system is designed which could detect the ozone concentration in real-time online, and achieve closed-loop control of the ozone production process. Results With the real-time monitoring and control functions of the ozone concentration, this disinfection machine could keep ozone concentration of bedspread in the best sterilization effect. Conclusion The bed unit ozone disinfection machine has a better effect on killing multiplication bacteria and fungi by ozone fumigation, and achieves speciifcation requirements.

  5. Robotic weed monitoring

    DEFF Research Database (Denmark)

    Bochtis, Dionysis; Sørensen, Claus Aage Grøn; Jørgensen, R N

    2011-01-01

    -farm operating console, the mobile robotic unit, and a field server for generating and storingmaps. The hypothesis is that it is possible to automate the planning and execution of theoperation of monitoring of the in-field weed density and species distribution. The developedplanning system includes the automatic...... of the weed monitoring operation.Key words: autonomous vehicles, farm management, mission planning, route planning,sampling....

  6. Regional monitoring program

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, B.V.; Soldat, J.K.

    1957-08-26

    The purpose of the Regional Monitoring program is to conduct surveys to detect, measure, and to evaluate environmental radiation, particularly that of HAPO origin. Estimations of total environmental dose and HAPO's contribution to this dose, in units of fraction of public exposure limits, are calculated. Corollary functions include the use of Regional Monitoring data to establish and predict trends in environmental exposure components, and to facilitate correlation of environmental radioactivity with plant processes, process changes, and waste disposal practices.

  7. A new device for monitoring moorings

    Digital Repository Service at National Institute of Oceanography (India)

    Namboothiri, E.G.; Krishnakumar, V.

    A new device - Mooring Monitoring Unit (MMU), which consists of an inwater unit and a deck unit has been designed to monitor mooring in situ. This device helps tracing underwater moorings, once its marker buoy is removed either by accident or theft...

  8. Observation of {mu}s time-scale protein dynamics in the presence of Ln{sup 3+} ions: application to the N-terminal domain of cardiac troponin C

    Energy Technology Data Exchange (ETDEWEB)

    Eichmueller, Christian [Sandoz GmbH (Austria); Skrynnikov, Nikolai R. [Purdue University, Department of Chemistry (United States)], E-mail: nikolai@purdue.edu

    2007-02-15

    The microsecond time-scale motions in the N-terminal domain of cardiac troponin C (NcTnC) loaded with lanthanide ions have been investigated by means of a {sup 1}H{sup N} off-resonance spin-lock experiment. The observed relaxation dispersion effects strongly increase along the series of NcTnC samples containing La{sup 3+}, Ce{sup 3+}, and Pr{sup 3+} ions. This rise in dispersion effects is due to modulation of long-range pseudocontact shifts by {mu}s time-scale dynamics. Specifically, the motion in the coordination sphere of the lanthanide ion (i.e. in the NcTnC EF-hand motif) causes modulation of the paramagnetic susceptibility tensor which, in turn, causes modulation of pseudocontact shifts. It is also probable that opening/closing dynamics, previously identified in Ca{sup 2+}-NcTnC, contributes to some of the observed dispersions. On the other hand, it is unlikely that monomer-dimer exchange in the solution of NcTnC is directly responsible for the dispersion effects. Finally, on-off exchange of the lanthanide ion does not seem to play any significant role. The amplification of dispersion effects by Ln{sup 3+} ions is a potentially useful tool for studies of {mu}s-ms motions in proteins. This approach makes it possible to observe the dispersions even when the local environment of the reporting spin does not change. This happens, for example, when the motion involves a 'rigid' structural unit such as individual {alpha}-helix. Even more significantly, the dispersions based on pseudocontact shifts offer better chances for structural characterization of the dynamic species. This method can be generalized for a large class of applications via the use of specially designed lanthanide-binding tags.

  9. Device for monitoring cell voltage

    Science.gov (United States)

    Doepke, Matthias [Garbsen, DE; Eisermann, Henning [Edermissen, DE

    2012-08-21

    A device for monitoring a rechargeable battery having a number of electrically connected cells includes at least one current interruption switch for interrupting current flowing through at least one associated cell and a plurality of monitoring units for detecting cell voltage. Each monitoring unit is associated with a single cell and includes a reference voltage unit for producing a defined reference threshold voltage and a voltage comparison unit for comparing the reference threshold voltage with a partial cell voltage of the associated cell. The reference voltage unit is electrically supplied from the cell voltage of the associated cell. The voltage comparison unit is coupled to the at least one current interruption switch for interrupting the current of at least the current flowing through the associated cell, with a defined minimum difference between the reference threshold voltage and the partial cell voltage.

  10. Monitoring Cray Cooling Systems

    Energy Technology Data Exchange (ETDEWEB)

    Maxwell, Don E [ORNL; Ezell, Matthew A [ORNL; Becklehimer, Jeff [Cray, Inc.; Donovan, Matthew J [ORNL; Layton, Christopher C [ORNL

    2014-01-01

    While sites generally have systems in place to monitor the health of Cray computers themselves, often the cooling systems are ignored until a computer failure requires investigation into the source of the failure. The Liebert XDP units used to cool the Cray XE/XK models as well as the Cray proprietary cooling system used for the Cray XC30 models provide data useful for health monitoring. Unfortunately, this valuable information is often available only to custom solutions not accessible by a center-wide monitoring system or is simply ignored entirely. In this paper, methods and tools used to harvest the monitoring data available are discussed, and the implementation needed to integrate the data into a center-wide monitoring system at the Oak Ridge National Laboratory is provided.

  11. Validation of a new software version for monitoring of the core of the Unit 2 of the Laguna Verde power plant with ARTS; Validacion de una nueva version del software para monitoreo del nucleo de la Unidad 2 de la Central Laguna Verde con ARTS

    Energy Technology Data Exchange (ETDEWEB)

    Calleros, G.; Riestra, M.; Ibanez, C.; Lopez, X.; Vargas, A.; Mendez, A.; Gomez, R. [CFE, Central Nucleoelectrica de Laguna Verde, Alto Lucero, Veracruz (Mexico)]. e-mail: gcm9acpp@cfe.gob.mx

    2005-07-01

    In this work it is intended a methodology to validate a new version of the software used for monitoring the reactor core, which requires of the evaluation of the thermal limits settled down in the Operation Technical Specifications, for the Unit 2 of Laguna Verde with ARTS (improvements to the APRMs, Rod Block Monitor and Technical specifications). According to the proposed methodology, those are shown differences found in the thermal limits determined with the new versions and previous of the core monitoring software. Author)

  12. Motor unit action potential conduction velocity estimated from surface electromyographic signals using image processing techniques.

    Science.gov (United States)

    Soares, Fabiano Araujo; Carvalho, João Luiz Azevedo; Miosso, Cristiano Jacques; de Andrade, Marcelino Monteiro; da Rocha, Adson Ferreira

    2015-09-17

    In surface electromyography (surface EMG, or S-EMG), conduction velocity (CV) refers to the velocity at which the motor unit action potentials (MUAPs) propagate along the muscle fibers, during contractions. The CV is related to the type and diameter of the muscle fibers, ion concentration, pH, and firing rate of the motor units (MUs). The CV can be used in the evaluation of contractile properties of MUs, and of muscle fatigue. The most popular methods for CV estimation are those based on maximum likelihood estimation (MLE). This work proposes an algorithm for estimating CV from S-EMG signals, using digital image processing techniques. The proposed approach is demonstrated and evaluated, using both simulated and experimentally-acquired multichannel S-EMG signals. We show that the proposed algorithm is as precise and accurate as the MLE method in typical conditions of noise and CV. The proposed method is not susceptible to errors associated with MUAP propagation direction or inadequate initialization parameters, which are common with the MLE algorithm. Image processing -based approaches may be useful in S-EMG analysis to extract different physiological parameters from multichannel S-EMG signals. Other new methods based on image processing could also be developed to help solving other tasks in EMG analysis, such as estimation of the CV for individual MUs, localization and tracking of innervation zones, and study of MU recruitment strategies.

  13. Monitoring of mass flux of catalyst FCC in a Cold Pilot Unit by gamma radiation transmission; Monitoramento da taxa de fluxo do catalisador FCC em uma unidade piloto a frio por medicao de transmissao gama

    Energy Technology Data Exchange (ETDEWEB)

    Brito, Marcio Fernando Paixao de

    2014-09-01

    This paper proposes a model for monitoring the mass flow of catalyst FCC - Fluid Catalytic Cracking - in a CPU - Cold Pilot unit - due to the injection of air and solid by gamma radiation transmission. The CPU simplifies the process of FCC, which is represented by the catalyst cycle, and it was constructed of acrylic, so that the flow can be visualized. The CPU consists of riser separation chamber and return column, and simulates the riser reactor of the FCC process. The catalyst is injected into the column back to the base of the riser, an inclined tube, where the compressed air means that there fluidization along the riser. When the catalyst comes in the separation chamber, the solid phase is sent to the return column, and the gas phase exits the system through one of the four cyclones at the top of the separation chamber. The transmission gamma of measures will be made by means of three test sections that have source and detector shielded. Pressure drop in the riser measurements are made through three pressure gauges positioned on the riser. The source used was Am-241 gamma ray with energy of 60 keV, and detector used was a scintillator of NaI (Tl) of 2 {sup x} 2{sup .} Measures the mass flow of catalyst are made by varying the seal of the catalyst, and density of solid in the riser because with the combination of these measures can determine the speed of the catalyst in the riser. The results show that the transmission gamma is a suitable technique for monitoring the flow of catalyst, flow model in CPU is annular, tomography third generation is more appropriate to study the CPU and the density variation in circulation in the CPU decreases linearly with increasing air flow. (author)

  14. Physiological consequences of doublet discharges on motoneuronal firing and motor unit force

    Directory of Open Access Journals (Sweden)

    Włodzimierz eMrówczyński

    2015-03-01

    Full Text Available The double discharges are observed at the onset of contractions of mammalian motor units (MUs, especially during their recruitment to strong or fast movements. Doublets lead to MU force increase and improve ability of muscles to maintain high force during prolonged contractions. In this review we discuss an ability to produce doublets by fast and slow motoneurons (MNs, their influence on the course of action potential afterhyperpolarization as well as its role in modulation of the initial stage of the firing pattern of MNs. In conclusion, a generation of doublets is an important strategy of motor control, responsible for fitting the motoneuronal firing rate to the optimal for MUs at the start of their contraction, necessary for increment of muscle force.

  15. Post-Closure Inspection and Monitoring Report for Corrective Action Unit 110: Area 3 WMD U-3ax/bl Crater, Nevada Test Site, Nevada, For the Period July 2007-June 2008

    Energy Technology Data Exchange (ETDEWEB)

    NSTec Environmental Restoration

    2008-08-01

    This Post-Closure Inspection and Monitoring Report (PCIMR) provides the results of inspections and monitoring for Corrective Action Unit (CAU) 110, Area 3 WMD [Waste Management Division] U-3ax/bl Crater. This PCIMR includes an analysis and summary of the site inspections, repairs and maintenance, meteorological information, and soil moisture monitoring data obtained at CAU 110 for the period July 2007 through June 2008. Site inspections of the cover were performed quarterly to identify any significant changes to the site requiring action. The overall condition of the cover, perimeter fence, and use restriction (UR) warning signs was good. However, settling was observed that exceeded the action level as specified in Section VII.B.7 of the Hazardous Waste Permit Number NEV HW021 (Nevada Division of Environmental Protection, 2005). This permit states that cracks or settling greater than 15 centimeters (6 inches) deep that extend 1.0 meter (m) (3 feet [ft]) or more on the cover will be evaluated and repaired within 60 days of detection. Two areas of settling and cracks were observed on the south and east edges of the cover during the September 2007 inspection that exceeded the action level and required repair. The areas were repaired in October 2007. Additional settling and cracks were observed along the east side of the cover during the December 2007 inspection that exceeded the action level, and the area was repaired in January 2008. Significant animal burrows were also observed during the March 2008 inspection, and small mammal trapping and relocation was performed in April 2008. The semiannual subsidence surveys were performed in September 2007 and March 2008. No significant subsidence was observed in the survey data. Monument 5 shows the greatest amount of subsidence (-0.02 m [-0.08 ft] compared to the baseline survey of 2000). This amount is negligible and near the resolution of the survey instruments; it does not indicate that subsidence is occurring overall on

  16. Émond, Anne-Marie, coord. - Le musée: Entre la recherche et l’enseignement/The museum: between research and education

    Directory of Open Access Journals (Sweden)

    João Pedro Fróis

    2013-04-01

    Full Text Available Os estudos sobre a museologia praticada no Canadá têm mostrado o interesse reiterado pela educação em museus de arte e de ciência. Parte desta investigação tem sido organizada na Universidade de Montreal e materializada através de projetos de investigação desenvolvidos pelo Groupe de recherche sur les musées et l'éducation des adultes. A editora científica deste livro, Anne-Marie Émond, professora da Faculdade de Ciências da Educação da Universidade de Montreal, ex-curadora do serviço educati...

  17. Further enhancement of the critical temperature up to 105 K of hydrogen loaded YBCO melted samples by {mu}s pulsed electrolysis

    Energy Technology Data Exchange (ETDEWEB)

    Di Gioacchino, D. [INFN, Frascati (Italy). Laboratori Nazionali di Frascati; Pripodi, P.; Celani, F.; Spallone, A.

    1996-11-01

    In this paper they report results about enhancement of the transition temperatures of Y{sub 1} Ba{sub 2} Cu{sub 3} O{sub 7{delta}} melted samples hydrogen loaded (H-YBCO) with high power {mu}s pulsed electrolysis. The fundamental AC magnetic susceptibility has been measured as a function of the temperature for different frequency values of the exciting magnetic field. The H-YBCO sample exhibited a magnetic on-set temperature (T{sub on}) as high as 105 K. The susceptibility behaviour below the T{sub on} shows significant change of shape. Result on a sintered YBCO pellets have been reproduced using melted YBCO samples.

  18. Anti-cholesterol activity test of tanjung (Mimusops elengi L.) leaf extract in the water using in vivo method in mice (Mus musculus L.) DDY-strain

    Science.gov (United States)

    Tristantini, Dewi; Pradana, Bhayangkara Tegar

    2017-02-01

    High cholesterol level in blood is one of deadly cardiovascular disease's causes which is triggered by accumulation of cholesterol patching in blood vessels through heart and using synthetic medicine has several side effect. However, tanjung (M. elengi) which abundant in Indonesia is believed that it can strengthen and clean plaque in blood vessels wall. In this study, anti-cholesterol activity of tanjung (M. elengi) leaf extract in the water will be tested by in vivo method to 6 group of mice (Mus musculus) DDY-strain. The result showed that tanjung (M. elengi) leaf extract has significant effect to decrease total cholesterol level of mice, more extract given to mice, it will give higher cholesterol decreasing. TE 3 can decrease cholesterol level as much as 36%. In this study, it can be concluded that tanjung (M. elengi) leaf extract can be used as cholesterol decreasing medicine.

  19. Phylogenetic relationships of intraspecific forms of the house mouse Mus musculus: Analysis of variability of the control region (D-loop) of mitochondrial DNA.

    Science.gov (United States)

    Maltsev, A N; Stakheev, V V; Bogdanov, A S; Fomina, E S; Kotenkova, E V

    2015-11-01

    Analysis of the control region of mitochondrial DNA (mtDNA) or D-loop of 96 house mice (Mus musculus) from Russia, Moldova, Armenia, Azerbaijan, Kazakhstan, and Turkmenistan has been used to reconstruct the phylogenetic relationships and phylogeographic patterns of intraspecific forms. New data on the phylogenetic structure of the house mouse are presented. Three phylogroups can be reliably distinguished in the eastern part of the M. musculus species range, the first one mainly comprising the haplotypes of mice from Transcaucasia (Armenia); the second one, the haplotypes of mice from Kazakhstan; and the third one, the haplotypes of mice from Siberia and some other regions. The morphological subspecies M. m. wagneri and M. m. gansuensis have proved to be genetically heterogeneous and did not form discrete phylogroups in the phylogenetic tree.

  20. Bank voles (Myodes glareolus) and house mice (Mus musculus musculus; M. m. domesticus) in Europe are each parasitized by their own distinct species of Aspiculuris (Nematoda, Oxyurida).

    Science.gov (United States)

    Behnke, J M; Stewart, A; Bajer, A; Grzybek, M; Harris, P D; Lowe, A; Ribas, A; Smales, L; Vandegrift, K J

    2015-10-01

    The molecular phylogeny and morphology of the oxyuroid nematode genus Aspiculuris from voles and house mice has been examined. Worms collected from Myodes glareolus in Poland, Eire and the UK are identified as Aspiculuris tianjinensis, previously known only from China, while worms from Mus musculus from a range of locations in Europe and from laboratory mice, all conformed to the description of Aspiculuris tetraptera. Worms from voles and house mice are not closely related and are not derived from each other, with A. tianjinensis being most closely related to Aspiculuris dinniki from snow voles and to an isolate from Microtus longicaudus in the Nearctic. Both A. tianjinensis and A. tetraptera appear to represent recent radiations within their host groups; in voles, this radiation cannot be more than 2 million years old, while in commensal house mice it is likely to be less than 10,000 years old. The potential of Aspiculuris spp. as markers of host evolution is highlighted.

  1. Two genetic determinants acquired late in Mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency.

    Directory of Open Access Journals (Sweden)

    Jun Li

    2012-01-01

    Full Text Available Mouse apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like editing complex 3 (mA3, an intracellular antiviral factor, has 2 allelic variations that are linked with different susceptibilities to beta- and gammaretrovirus infections among various mouse strains. In virus-resistant C57BL/6 (B6 mice, mA3 transcripts are more abundant than those in susceptible BALB/c mice both in the spleen and bone marrow. These strains of mice also express mA3 transcripts with different splicing patterns: B6 mice preferentially express exon 5-deficient (Δ5 mA3 mRNA, while BALB/c mice produce exon 5-containing full-length mA3 mRNA as the major transcript. Although the protein product of the Δ5 mRNA exerts stronger antiretroviral activities than the full-length protein, how exon 5 affects mA3 antiviral activity, as well as the genetic mechanisms regulating exon 5 inclusion into the mA3 transcripts, remains largely uncharacterized. Here we show that mA3 exon 5 is indeed a functional element that influences protein synthesis at a post-transcriptional level. We further employed in vitro splicing assays using genomic DNA clones to identify two critical polymorphisms affecting the inclusion of exon 5 into mA3 transcripts: the number of TCCT repeats upstream of exon 5 and the single nucleotide polymorphism within exon 5 located 12 bases upstream of the exon 5/intron 5 boundary. Distribution of the above polymorphisms among different Mus species indicates that the inclusion of exon 5 into mA3 mRNA is a relatively recent event in the evolution of mice. The widespread geographic distribution of this exon 5-including genetic variant suggests that in some Mus populations the cost of maintaining an effective but mutagenic enzyme may outweigh its antiviral function.

  2. Effect of VCO to leucocyte differential count, glucose levels and blood creatinine of hyperglycemic and ovalbumin sensitized Mus musculus Balb/c

    Directory of Open Access Journals (Sweden)

    RUBEN DHARMAWAN

    2009-03-01

    Full Text Available Abstract. Handajani NS, Dharmawan R. 2009. Effect of VCO to leucocyte differential count, glucose levels and blood creatinine of hyperglycemic and ovalbumin sensitized Mus musculus Balb/c. Nusantara Bioscience 1: 1-8. Chemical medicines and insulin can decrease glucose blood level on hyperglycemic patients with macro vascular side effect. Diabetes and allergy incidences are influenced by quality and quantity of leucocytes. Lauric acid within VCO reports decreased glucose blood level of diabetes and some allergy incidents. The purpose of the study is to know the effect of VCO on glucose blood level, differential leucocytes count and creatinine blood level on hyperglycemic and normoglicemic ovalbumin sensitized mice. Forty five (45 male (mice of Mus musculus Balb/c with average weight of 35 g are divided into 9 groups with 5 repetitions, those are 4 non alloxan groups and 5 alloxan induced hyperglycemic groups. On 22nd day to 36th day they are sensitize to ovalbumin as allergen. Blood sample was obtained by orbital vena using heparin as anti coagulant in order measuring glucose blood level by GOD method to 6 times, on 1st, 4th, 18th, 22nd, 32nd and 37th days, then are tested by ANOVA followed by DMRT 0.05. On 37th day, differential leucocytes are determined, blood level are counted, and then compared to normal value. The result of this study were that within differential leucocytes count of hyperglycemic mice, neutrophile percentage were much lower than the normal value (3.22%, and lymphocyte percentage were much higher than the normal value (94.54%. Consumed 0.003 mL/35 g VCO more 18 days decreased glucose blood level on hyperglycemic mice, decreased basophile percentage of ovalbumin sensitized mice, normalized neutrophile percentage no increased creatinine blood level.

  3. Two New Species of Demodex (Acari: Demodecidae) with a Redescription of Demodex musculi and Data on Parasitism in Mus musculus (Rodentia: Muridae).

    Science.gov (United States)

    Izdebska, Joanna N; Rolbiecki, Leszek

    2015-07-01

    This article describes two new skin mite species found on the house mouse Mus musculus L., 1758. Demodex marculus sp. nov. is a very small demodecid mite (adult stages, on average, 99 µm in length) found in mouse skin in the abdomen, back, limbs, and anal area. It is characterized by relatively large bossing hammer-shaped supracoxal spines, embedded in the trapezoidal gnathosoma. Demodex fusiformis sp. nov., in turn, is a little larger (adult stages on average 111 µm in length), with a small oval gnathosoma equipped with fine, knob-like supracoxal spines. It was found in the skin of abdomen, back, and limbs. Moreover, Demodex musculi (Oudemans, 1897) was redescribed, which is small demodecid mite (adult stages on average 142 µm in length) and characterized by relatively large morphological variation and considerable sexual dimorphism. The characteristic feature of this