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Sample records for models typically involve

  1. Modeling typical performance measures

    NARCIS (Netherlands)

    Weekers, Anke Martine

    2009-01-01

    In the educational, employment, and clinical context, attitude and personality inventories are used to measure typical performance traits. Statistical models are applied to obtain latent trait estimates. Often the same statistical models as the models used in maximum performance measurement are appl

  2. Modelling Typical Online Language Learning Activity

    Science.gov (United States)

    Montoro, Carlos; Hampel, Regine; Stickler, Ursula

    2014-01-01

    This article presents the methods and results of a four-year-long research project focusing on the language learning activity of individual learners using online tasks conducted at the University of Guanajuato (Mexico) in 2009-2013. An activity-theoretical model (Blin, 2010; Engeström, 1987) of the typical language learning activity was used to…

  3. Modelling object typicality in description logics - [Workshop on Description Logics

    CSIR Research Space (South Africa)

    Britz, K

    2009-07-01

    Full Text Available The authors presents a semantic model of typicality of concept members in description logics that accords well with a binary, globalist cognitive model of class membership and typicality. The authors define a general preferential semantic framework...

  4. The involvement of limbic structures in typical and atypical absence epilepsy

    NARCIS (Netherlands)

    Onat, F.Y.; Luijtelaar, E.L.J.M. van; Nehlig, A.; Snead, O.C.

    2013-01-01

    Typical and atypical seizures of absence epilepsy are thought to be generated by a rhythmogenic interplay between the cortex and the thalamus. However, the question remains as to which other subcortical and extrathalamic structures are involved in the pathophysiology of typical and atypical absence

  5. Chronic recurrent multifocal osteomyelitis: typical patterns of bone involvement in whole-body bone scintigraphy.

    Science.gov (United States)

    Acikgoz, Gunsel; Averill, Lauren W

    2014-08-01

    Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease of unknown etiology. It affects children and adolescents predominantly and occurs mostly in the female population. It is characterized by the insidious onset of pain and swelling, with a fluctuating clinical course of relapses and remissions. Typically, several bones are affected, either synchronously or metachronously, and bilateral involvement is common. CRMO most commonly affects the metaphysis of long bones, especially the tibia, femur, and clavicle. The spine, pelvis, ribs, sternum, and mandible may also be affected. Although lesions are mostly multiple, patients may present with a single symptomatic focus. Radiographic findings may be negative early in the course of the disease. Bone scintigraphy is useful in determining the presence of abnormality and the extent of disease. The imaging and clinical features of CRMO overlap with those of infectious osteomyelitis, bone malignancy, and inflammatory arthritis. Nonetheless, CRMO can be confidently diagnosed with the recognition of typical imaging patterns in the appropriate clinical setting. This article reviews imaging findings with special emphasis on bone scintigraphy and specific disease sites.

  6. Analysis and Comparison of Typical Models within Distribution Network Design

    DEFF Research Database (Denmark)

    Jørgensen, Hans Jacob; Larsen, Allan; Madsen, Oli B.G.

    are covered in the categorisation include fixed vs. general networks, specialised vs. general nodes, linear vs. nonlinear costs, single vs. multi commodity, uncapacitated vs. capacitated activities, single vs. multi modal and static vs. dynamic. The models examined address both strategic and tactical planning...... for educational purposes. Furthermore, the paper can be seen as a practical introduction to network design modelling as well as a being an art manual or recipe when constructing such a model.......This paper investigates the characteristics of typical optimisation models within Distribution Network Design. During the paper fourteen models known from the literature will be thoroughly analysed. Through this analysis a schematic approach to categorisation of distribution network design models...

  7. Flux measurement and modeling in a typical mediterranean vineyard

    Science.gov (United States)

    Marras, Serena; Bellucco, Veronica; Pyles, David R.; Falk, Matthias; Sirca, Costantino; Duce, Pierpaolo; Snyder, Richard L.; Tha Paw U, Kyaw; Spano, Donatella

    2014-05-01

    Vineyard ecosystems are typical in the Mediterranean area, since wine is one of the most important economic sectors. Nevertheless, only a few studies have been conducted to investigate the interactions between this kind of vegetation and the atmosphere. These information are important both to understand the behaviour of such ecosystems in different environmental conditions, and are crucial to parameterize crop and flux simulation models. Combining direct measurements and modelling can obtain reliable estimates of surface fluxes and crop evapotranspiration. This study would contribute both to (1) directly measure energy fluxes and evapotranspiration in a typical Mediterranean vineyard, located in the South of Sardinia (Italy), through the application of the Eddy Covariance micrometeorological technique and to (2) evaluate the land surface model ACASA (Advanced-Canopy-Atmosphere-Soil Algorithm) in simulating energy fluxes and evapotranspiration over vineyard. Independent datasets of direct measurements were used to calibrate and validate model results during the growing period. Statistical analysis was performed to evaluate model performance and accuracy in predicting surface fluxes. Results will be showed as well as the model capability to be used for future studies to predict energy fluxes and crop water requirements under actual and future climate.

  8. A Modal Model to Simulate Typical Structural Dynamic Nonlinearity

    Energy Technology Data Exchange (ETDEWEB)

    Pacini, Benjamin Robert [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Mayes, Randall L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Roettgen, Daniel R [Univ. of Wisconsin, Madison, WI (United States)

    2015-10-01

    Some initial investigations have been published which simulate nonlinear response with almost traditional modal models: instead of connecting the modal mass to ground through the traditional spring and damper, a nonlinear Iwan element was added. This assumes that the mode shapes do not change with amplitude and there are no interactions between modal degrees of freedom. This work expands on these previous studies. An impact experiment is performed on a structure which exhibits typical structural dynamic nonlinear response, i.e. weak frequency dependence and strong damping dependence on the amplitude of vibration. Use of low level modal test results in combination with high level impacts are processed using various combinations of modal filtering, the Hilbert Transform and band-pass filtering to develop response data that are then fit with various nonlinear elements to create a nonlinear pseudo-modal model. Simulations of forced response are compared with high level experimental data for various nonlinear element assumptions.

  9. Aeroelastic Calculations Using CFD for a Typical Business Jet Model

    Science.gov (United States)

    Gibbons, Michael D.

    1996-01-01

    Two time-accurate Computational Fluid Dynamics (CFD) codes were used to compute several flutter points for a typical business jet model. The model consisted of a rigid fuselage with a flexible semispan wing and was tested in the Transonic Dynamics Tunnel at NASA Langley Research Center where experimental flutter data were obtained from M(sub infinity) = 0.628 to M(sub infinity) = 0.888. The computational results were computed using CFD codes based on the inviscid TSD equation (CAP-TSD) and the Euler/Navier-Stokes equations (CFL3D-AE). Comparisons are made between analytical results and with experiment where appropriate. The results presented here show that the Navier-Stokes method is required near the transonic dip due to the strong viscous effects while the TSD and Euler methods used here provide good results at the lower Mach numbers.

  10. "What Brings Him Here Today?": Medical Problem Presentation Involving Children with Autism Spectrum Disorders and Typically Developing Children

    Science.gov (United States)

    Solomon, Olga; Heritage, John; Yin, Larry; Maynard, Douglas W.; Bauman, Margaret L.

    2016-01-01

    Conversation and discourse analyses were used to examine medical problem presentation in pediatric care. Healthcare visits involving children with ASD and typically developing children were analyzed. We examined how children's communicative and epistemic capabilities, and their opportunities to be socialized into a competent patient role are…

  11. Modeling interdisciplinary activities involving Mathematics

    DEFF Research Database (Denmark)

    Iversen, Steffen Møllegaard

    2006-01-01

    In this paper a didactical model is presented. The goal of the model is to work as a didactical tool, or conceptual frame, for developing, carrying through and evaluating interdisciplinary activities involving the subject of mathematics and philosophy in the high schools. Through the terms...... domains (Michelsen, 2001, 2005a, 2005b). Furthermore the theoretical description rest on a series of qualitative interviews with teachers from the Danish high school (grades 9-11) conducted recently. The special case of concrete interdisciplinary activities between mathematics and philosophy is also...

  12. Modeling interdisciplinary activities involving Mathematics

    DEFF Research Database (Denmark)

    Iversen, Steffen Møllegaard

    2006-01-01

    In this paper a didactical model is presented. The goal of the model is to work as a didactical tool, or conceptual frame, for developing, carrying through and evaluating interdisciplinary activities involving the subject of mathematics and philosophy in the high schools. Through the terms...... of Horizontal Intertwining, Vertical Structuring and Horizontal Propagation the model consists of three phases, each considering different aspects of the nature of interdisciplinary activities. The theoretical modelling is inspired by work which focuses on the students abilities to concept formation in expanded...... domains (Michelsen, 2001, 2005a, 2005b). Furthermore the theoretical description rest on a series of qualitative interviews with teachers from the Danish high school (grades 9-11) conducted recently. The special case of concrete interdisciplinary activities between mathematics and philosophy is also...

  13. Analysis and Comparison of Typical Models within Distribution Network Design

    DEFF Research Database (Denmark)

    Jørgensen, Hans Jacob; Larsen, Allan; Madsen, Oli B.G.

    a number of important issues which have been identified when addressing the Distribution Network Design problem from a modelling angle. More specifically, we present an analysis of the research which has been performed in utilizing operational research in developing and optimising distribution systems....

  14. Typical Phases of Transformative Learning: A Practice-Based Model

    Science.gov (United States)

    Nohl, Arnd-Michael

    2015-01-01

    Empirical models of transformative learning offer important insights into the core characteristics of this concept. Whereas previous analyses were limited to specific social groups or topical terrains, this article empirically typifies the phases of transformative learning on the basis of a comparative analysis of various social groups and topical…

  15. Early pulmonary involvement of anti-CADM-140 autoantibody-positive rapidly progressive interstitial lung disease preceding typical cutaneous symptoms.

    Science.gov (United States)

    Tamai, Koji; Tachikawa, Ryo; Otsuka, Kyoko; Ueda, Hiroyuki; Hosono, Yuji; Tomii, Keisuke

    2014-01-01

    We herein report a patient with clinically amyopathic dermatomyositis (CADM) who developed anti-CADM-140 autoantibody in association with rapidly progressive interstitial lung disease (RP-ILD). Chest high-resolution computed tomography (HRCT) revealed early pulmonary involvement preceding typical cutaneous lesions. Primary lesions of patchy peribronchial opacity developed ground-glass opacity and consolidation with architectural distortion and traction bronchiectasis. The possibility of anti-CADM-140 autoantibody-associated RP-ILD should be considered when patchy peribronchial opacity of an unknown cause is visible on chest HRCT.

  16. Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement.

    Science.gov (United States)

    Paul, Lynn K

    2011-03-01

    This review provides an overview of the involvement of the corpus callosum (CC) in a variety of developmental disorders that are currently defined exclusively by genetics, developmental insult, and/or behavior. I begin with a general review of CC development, connectivity, and function, followed by discussion of the research methods typically utilized to study the callosum. The bulk of the review concentrates on specific developmental disorders, beginning with agenesis of the corpus callosum (AgCC)-the only condition diagnosed exclusively by callosal anatomy. This is followed by a review of several genetic disorders that commonly result in social impairments and/or psychopathology similar to AgCC (neurofibromatosis-1, Turner syndrome, 22q11.2 deletion syndrome, Williams yndrome, and fragile X) and two forms of prenatal injury (premature birth, fetal alcohol syndrome) known to impact callosal development. Finally, I examine callosal involvement in several common developmental disorders defined exclusively by behavioral patterns (developmental language delay, dyslexia, attention-deficit hyperactive disorder, autism spectrum disorders, and Tourette syndrome).

  17. Observations involving broadband impedance modelling

    Energy Technology Data Exchange (ETDEWEB)

    Berg, J.S. [Stanford Linear Accelerator Center, Menlo Park, CA (United States)

    1996-08-01

    Results for single- and multi-bunch instabilities can be significantly affected by the precise model that is used for the broadband impedance. This paper discusses three aspects of broadband impedance modelling. The first is an observation of the effect that a seemingly minor change in an impedance model has on the single-bunch mode coupling threshold. The second is a successful attempt to construct a model for the high-frequency tails of an r.f. cavity. The last is a discussion of requirements for the mathematical form of an impedance which follow from the general properties of impedances. (author)

  18. Observations involving broadband impedance modelling

    Energy Technology Data Exchange (ETDEWEB)

    Berg, J.S.

    1995-08-01

    Results for single- and multi-bunch instabilities can be significantly affected by the precise model that is used for the broadband impendance. This paper discusses three aspects of broadband impendance modeling. The first is an observation of the effect that a seemingly minor change in an impedance model has on the single-bunch mode coupling threshold. The second is a successful attempt to construct a model for the high-frequency tails of an r.f cavity. The last is a discussion of requirements for the mathematical form of an impendance which follow from the general properties of impendances.

  19. A Case Study on Procedural Modeling of Geo-Typical Southern Afghasistan Terrain

    NARCIS (Netherlands)

    Smelik, R.M.; Kraker, J.K. de; Tutenel, T.; Bidarra, R.

    2009-01-01

    A cost-effective method of military training is game-based training, for which custom geo-typical terrain models are often most suitable. However, for training instructors, scenario preparation is seriously slowed down by the complexity of current terrain modeling tools and methods. They would

  20. A Case Study on Procedural Modeling of Geo-Typical Southern Afghasistan Terrain

    NARCIS (Netherlands)

    Smelik, R.M.; Kraker, J.K. de; Tutenel, T.; Bidarra, R.

    2009-01-01

    A cost-effective method of military training is game-based training, for which custom geo-typical terrain models are often most suitable. However, for training instructors, scenario preparation is seriously slowed down by the complexity of current terrain modeling tools and methods. They would benef

  1. Decision-Tree Models of Categorization Response Times, Choice Proportions, and Typicality Judgments

    Science.gov (United States)

    Lafond, Daniel; Lacouture, Yves; Cohen, Andrew L.

    2009-01-01

    The authors present 3 decision-tree models of categorization adapted from T. Trabasso, H. Rollins, and E. Shaughnessy (1971) and use them to provide a quantitative account of categorization response times, choice proportions, and typicality judgments at the individual-participant level. In Experiment 1, the decision-tree models were fit to…

  2. Decision-Tree Models of Categorization Response Times, Choice Proportions, and Typicality Judgments

    Science.gov (United States)

    Lafond, Daniel; Lacouture, Yves; Cohen, Andrew L.

    2009-01-01

    The authors present 3 decision-tree models of categorization adapted from T. Trabasso, H. Rollins, and E. Shaughnessy (1971) and use them to provide a quantitative account of categorization response times, choice proportions, and typicality judgments at the individual-participant level. In Experiment 1, the decision-tree models were fit to…

  3. Bullying Prevention and the Parent Involvement Model

    Science.gov (United States)

    Kolbert, Jered B.; Schultz, Danielle; Crothers, Laura M.

    2014-01-01

    A recent meta-analysis of bullying prevention programs provides support for social-ecological theory, in which parent involvement addressing child bullying behaviors is seen as important in preventing school-based bullying. The purpose of this manuscript is to suggest how Epstein and colleagues' parent involvement model can be used as a…

  4. Body ideals in women after viewing images of typical and healthy weight models.

    Science.gov (United States)

    Owen, Rebecca; Spencer, Rebecca M C

    2013-09-01

    Viewing thin models, pervasive in popular culture, is correlated with body dissatisfaction and anxiety in women. Whether or not the same is true when viewing healthy weight models is unknown. In this study we tested whether viewing healthy weight models increases the ideal female body size. Body image, anxiety, happiness and depression were measured in 44 female participants following viewing of images of thin or healthy weight models (within-subject separated by two weeks). We found that after viewing images of healthy weight models, women's body ideals (as measured by a participant-adjusted virtual model) were significantly larger than when the same women viewed images of very thin models. This effect was greatest in those women with the highest levels of baseline anxiety (as measured by the Hospital Anxiety and Depression Scale). These results suggest that viewing healthy weight models results in more healthy body ideals than those typically promoted through media. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. Learning models of activities involving interacting objects

    DEFF Research Database (Denmark)

    Manfredotti, Cristina; Pedersen, Kim Steenstrup; Hamilton, Howard J.;

    2013-01-01

    We propose the LEMAIO multi-layer framework, which makes use of hierarchical abstraction to learn models for activities involving multiple interacting objects from time sequences of data concerning the individual objects. Experiments in the sea navigation domain yielded learned models that were...

  6. Learning models of activities involving interacting objects

    DEFF Research Database (Denmark)

    Manfredotti, Cristina; Pedersen, Kim Steenstrup; Hamilton, Howard J.

    2013-01-01

    We propose the LEMAIO multi-layer framework, which makes use of hierarchical abstraction to learn models for activities involving multiple interacting objects from time sequences of data concerning the individual objects. Experiments in the sea navigation domain yielded learned models that were t...

  7. Learning models of activities involving interacting objects

    DEFF Research Database (Denmark)

    Manfredotti, Cristina; Pedersen, Kim Steenstrup; Hamilton, Howard J.;

    2013-01-01

    We propose the LEMAIO multi-layer framework, which makes use of hierarchical abstraction to learn models for activities involving multiple interacting objects from time sequences of data concerning the individual objects. Experiments in the sea navigation domain yielded learned models that were...... then successfully applied to activity recognition, activity simulation and multi-target tracking. Our method compares favourably with respect to previously reported results using Hidden Markov Models and Relational Particle Filtering....

  8. A comparative analysis of the two typical farmland transfer models in Chongqing

    Institute of Scientific and Technical Information of China (English)

    肖轶; 魏朝富; 尹珂; 罗光莲

    2009-01-01

    This paper attempts to conduct a comparative analysis of the two typical farmland transfer models introduced by Chongqing in its comprehensive coordinated reform experiment for balanced urban and rural development: i) the "pooling of land as shares" in Qilin village, Changshou district; and ii) the "homestead/house swap, contracted land/ social security swap" in Jiulongpo district. It is estimated that the former model offers lower land appreciation benef its than the latter; the former faces greater operational risks, whereas the latter can to a certain extent mitigate risks by boosting regulatory control and reasonable government guidance. The homestead/house swap, contracted land/social security swap model is therefore the preferred choice. It can solve a series of social security problems that arise after peasants are divorced from land and enable peasants to garner higher land appreciation benefits through farmland transfer.

  9. [Modeling Study of A Typical Summer Ozone Pollution Event over Yangtze River Delta].

    Science.gov (United States)

    Zhang, Liang; Zhu, Bin; Gao, Jin-hui; Kang, Han-qing; Yang, Peng; Wang, Hong-lei; Li, Yue-e; Shao, Ping

    2015-11-01

    WRF/Chem model was used to analyze the temporal and spatial distribution characteristics and physical and chemical mechanism of a typical summer ozone pollution event over Yangtze River Delta (YRD). The result showed that the model was capable of reproducing the temporal and spatial distribution and evolution characteristics of the typical summer ozone pollution event over YRD. The YRD region was mainly affected by the subtropical high-pressure control, and the weather conditions of sunshine, high temperature and small wind were favorable for the formation of photochemical pollution on August 10-18, 2013. The results of simulation showed that the spatial and temporal distribution of O3 was obviously affected by the meteorological fields, geographic location, regional transport and chemical formation over YRD. The sensitivity experiment showed that the O3 concentration affected by maritime airstream was low in Shanghai, but the impact of Shanghai emissions on the spatial and temporal distribution of O3 concentration over YRD was significant; The main contribution of the high concentration of O3 in Nanjing surface was chemical generation ( alkene and aromatic) and the vertical transport from high-altitude O3, whereas the main contribution of the high concentration of O3 in Hangzhou and Suzhou was physics process. The influence of the 15:00 peak concentration of O3 over YRD was very obvious when O3 precursor was reduced at the maximum O3 formation rate (11-13 h).

  10. A Modal Model to Simulate Typical Structural Dynamic Nonlinearity [PowerPoint

    Energy Technology Data Exchange (ETDEWEB)

    Mayes, Randall L.; Pacini, Benjamin Robert; Roettgen, Dan

    2016-01-01

    Some initial investigations have been published which simulate nonlinear response with almost traditional modal models: instead of connecting the modal mass to ground through the traditional spring and damper, a nonlinear Iwan element was added. This assumes that the mode shapes do not change with amplitude and there are no interactions between modal degrees of freedom. This work expands on these previous studies. An impact experiment is performed on a structure which exhibits typical structural dynamic nonlinear response, i.e. weak frequency dependence and strong damping dependence on the amplitude of vibration. Use of low level modal test results in combination with high level impacts are processed using various combinations of modal filtering, the Hilbert Transform and band-pass filtering to develop response data that are then fit with various nonlinear elements to create a nonlinear pseudo-modal model. Simulations of forced response are compared with high level experimental data for various nonlinear element assumptions.

  11. Modeling a typical winter-time dust event over the Arabian Peninsula and the Red Sea

    KAUST Repository

    Kalenderski, S.

    2013-02-20

    We used WRF-Chem, a regional meteorological model coupled with an aerosol-chemistry component, to simulate various aspects of the dust phenomena over the Arabian Peninsula and Red Sea during a typical winter-time dust event that occurred in January 2009. The model predicted that the total amount of emitted dust was 18.3 Tg for the entire dust outburst period and that the two maximum daily rates were ?2.4 Tg day-1 and ?1.5 Tg day-1, corresponding to two periods with the highest aerosol optical depth that were well captured by ground-and satellite-based observations. The model predicted that the dust plume was thick, extensive, and mixed in a deep boundary layer at an altitude of 3-4 km. Its spatial distribution was modeled to be consistent with typical spatial patterns of dust emissions. We utilized MODIS-Aqua and Solar Village AERONET measurements of the aerosol optical depth (AOD) to evaluate the radiative impact of aerosols. Our results clearly indicated that the presence of dust particles in the atmosphere caused a significant reduction in the amount of solar radiation reaching the surface during the dust event. We also found that dust aerosols have significant impact on the energy and nutrient balances of the Red Sea. Our results showed that the simulated cooling under the dust plume reached 100 W m-2, which could have profound effects on both the sea surface temperature and circulation. Further analysis of dust generation and its spatial and temporal variability is extremely important for future projections and for better understanding of the climate and ecological history of the Red Sea.

  12. Modeling a typical winter-time dust event over the Arabian Peninsula and the Red Sea

    Directory of Open Access Journals (Sweden)

    S. Kalenderski

    2013-02-01

    Full Text Available We used WRF-Chem, a regional meteorological model coupled with an aerosol-chemistry component, to simulate various aspects of the dust phenomena over the Arabian Peninsula and Red Sea during a typical winter-time dust event that occurred in January 2009. The model predicted that the total amount of emitted dust was 18.3 Tg for the entire dust outburst period and that the two maximum daily rates were ~2.4 Tg day−1 and ~1.5 Tg day−1, corresponding to two periods with the highest aerosol optical depth that were well captured by ground- and satellite-based observations. The model predicted that the dust plume was thick, extensive, and mixed in a deep boundary layer at an altitude of 3–4 km. Its spatial distribution was modeled to be consistent with typical spatial patterns of dust emissions. We utilized MODIS-Aqua and Solar Village AERONET measurements of the aerosol optical depth (AOD to evaluate the radiative impact of aerosols. Our results clearly indicated that the presence of dust particles in the atmosphere caused a significant reduction in the amount of solar radiation reaching the surface during the dust event. We also found that dust aerosols have significant impact on the energy and nutrient balances of the Red Sea. Our results showed that the simulated cooling under the dust plume reached 100 W m−2, which could have profound effects on both the sea surface temperature and circulation. Further analysis of dust generation and its spatial and temporal variability is extremely important for future projections and for better understanding of the climate and ecological history of the Red Sea.

  13. Enhanced air dispersion modelling at a typical Chinese nuclear power plant site: Coupling RIMPUFF with two advanced diagnostic wind models.

    Science.gov (United States)

    Liu, Yun; Li, Hong; Sun, Sida; Fang, Sheng

    2017-09-01

    An enhanced air dispersion modelling scheme is proposed to cope with the building layout and complex terrain of a typical Chinese nuclear power plant (NPP) site. In this modelling, the California Meteorological Model (CALMET) and the Stationary Wind Fit and Turbulence (SWIFT) are coupled with the Risø Mesoscale PUFF model (RIMPUFF) for refined wind field calculation. The near-field diffusion coefficient correction scheme of the Atmospheric Relative Concentrations in the Building Wakes Computer Code (ARCON96) is adopted to characterize dispersion in building arrays. The proposed method is evaluated by a wind tunnel experiment that replicates the typical Chinese NPP site. For both wind speed/direction and air concentration, the enhanced modelling predictions agree well with the observations. The fraction of the predictions within a factor of 2 and 5 of observations exceeds 55% and 82% respectively in the building area and the complex terrain area. This demonstrates the feasibility of the new enhanced modelling for typical Chinese NPP sites. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Modeling fault among motorcyclists involved in crashes.

    Science.gov (United States)

    Haque, Md Mazharul; Chin, Hoong Chor; Huang, Helai

    2009-03-01

    Singapore crash statistics from 2001 to 2006 show that the motorcyclist fatality and injury rates per registered vehicle are higher than those of other motor vehicles by 13 and 7 times, respectively. The crash involvement rate of motorcyclists as victims of other road users is also about 43%. The objective of this study is to identify the factors that contribute to the fault of motorcyclists involved in crashes. This is done by using the binary logit model to differentiate between at-fault and not-at-fault cases and the analysis is further categorized by the location of the crashes, i.e., at intersections, on expressways and at non-intersections. A number of explanatory variables representing roadway characteristics, environmental factors, motorcycle descriptions, and rider demographics have been evaluated. Time trend effect shows that not-at-fault crash involvement of motorcyclists has increased with time. The likelihood of night time crashes has also increased for not-at-fault crashes at intersections and expressways. The presence of surveillance cameras is effective in reducing not-at-fault crashes at intersections. Wet-road surfaces increase at-fault crash involvement at non-intersections. At intersections, not-at-fault crash involvement is more likely on single-lane roads or on median lane of multi-lane roads, while on expressways at-fault crash involvement is more likely on the median lane. Roads with higher speed limit have higher at-fault crash involvement and this is also true on expressways. Motorcycles with pillion passengers or with higher engine capacity have higher likelihood of being at-fault in crashes on expressways. Motorcyclists are more likely to be at-fault in collisions involving pedestrians and this effect is higher at night. In multi-vehicle crashes, motorcyclists are more likely to be victims than at-fault. Young and older riders are more likely to be at-fault in crashes than middle-aged group of riders. The findings of this study will help

  15. Improved Algorithm of SCS-CN Model Parameters in Typical Inland River Basin in Central Asia

    Science.gov (United States)

    Wang, Jin J.; Ding, Jian L.; Zhang, Zhe; Chen, Wen Q.

    2017-02-01

    Rainfall-runoff relationship is the most important factor for hydrological structures, social and economic development on the background of global warmer, especially in arid regions. The aim of this paper is find the suitable method to simulate the runoff in arid area. The Soil Conservation Service Curve Number (SCS-CN) is the most popular and widely applied model for direct runoff estimation. In this paper, we will focus on Wen-quan Basin in source regions of Boertala River. It is a typical valley of inland in Central Asia. First time to use the 16m resolution remote sensing image about high-definition earth observation satellite “Gaofen-1” to provide a high degree accuracy data for land use classification determine the curve number. Use surface temperature/vegetation index (TS/VI) construct 2D scatter plot combine with the soil moisture absorption balance principle calculate the moisture-holding capacity of soil. Using original and parameter algorithm improved SCS-CN model respectively to simulation the runoff. The simulation results show that the improved model is better than original model. Both of them in calibration and validation periods Nash-Sutcliffe efficiency were 0.79, 0.71 and 0.66,038. And relative error were3%, 12% and 17%, 27%. It shows that the simulation accuracy should be further improved and using remote sensing information technology to improve the basic geographic data for the hydrological model has the following advantages: 1) Remote sensing data having a planar characteristic, comprehensive and representative. 2) To get around the bottleneck about lack of data, provide reference to simulation the runoff in similar basin conditions and data-lacking regions.

  16. An ideal-typical model for comparing interprofessional relations and skill mix in health care.

    Science.gov (United States)

    Schönfelder, Walter; Nilsen, Elin Anita

    2016-11-08

    Comparisons of health system performance, including the regulations of interprofessional relations and the skill mix between health professions are challenging. National strategies for regulating interprofessional relations vary widely across European health care systems. Unambiguously defined and generally accepted performance indicators have to remain generic, with limited power for recognizing the organizational structures regulating interprofessional relations in different health systems. A coherent framework for in-depth comparisons of different models for organizing interprofessional relations and the skill mix between professional groups is currently not available. This study aims to develop an ideal-typical framework for categorizing skill mix and interprofessional relations in health care, and to assess the potential impact for different ideal types on care coordination and integrated service delivery. A document analysis of the Health Systems in Transition (HiT) reports published by the European Observatory on Health Systems and Policies was conducted. The HiT reports to 31 European health systems were analyzed using a qualitative content analysis and a process of meaning condensation. The educational tracks available to nurses have an impact on the professional autonomy for nurses, the hierarchy between professional groups, the emphasis given to negotiating skill mix, interdisciplinary teamwork and the extent of cooperation across the health and social service interface. Based on the results of the document analysis, three ideal types for regulating interprofessional relations and skill mix in health care are delimited. For each ideal type, outcomes on service coordination and holistic service delivery are described. Comparisons of interprofessional relations are necessary for proactive health human resource policies. The proposed ideal-typical framework provides the means for in-depth comparisons of interprofessional relations in the health care

  17. Typical structural elements of seismicity and impact crater morphology identified in GIS ENDDB digital models.

    Science.gov (United States)

    Mikheeva, Anna

    2014-05-01

    The subject database of the ENDDB system (Earth's Natural Disasters Database) is a combination of the EISC catalog (Earth's impact structures Catalog [1]) and seismological data of more than 60 earthquake catalogs (EC). ENDDB geographic subsystem uses the NASA ASTER GDEM data arrays to obtain a high-resolution (1 arc-second) shaded relief model, as well as the digital mapping technology, which consists in shading surface points according to their brightness controlled by the illumination angle. For example, the identifying impact craters by means of ENDDB begins with selecting the optimum base colors of the image, the parameters of illumination and shadow depth for constructing a shaded model on a regular grid of values. This procedure allows obtaining precise 3D images of the terrain and gravity patterns, and, moreover, furnishes data for recognizing standard morphological elements according to which impact structures can be visually detected. For constructing a shaded gravity anomaly with the ENDDB tools, Global marine gravity data (of models V16.1 and V18.1 [2]) are embedded into the system. These models, which are arrays of gravity pixel values, are of the resolution increased from the equator to the poles, being 30 arc-seconds per point on average. This resolution is the same as in the more recent V21.1 model. Due to these data, new morphological elements typical of impact structures, which are expressed in the shaded elevation and gravity models (identified using the ENDDB visualization tools) was found and compared in hundreds of craters from the EISC-catalog: tail-shaped asymmetry of relief, heart-shaped geometry of craters, and tail-shaped gravity lows [3] and so on. New diagnostic criteria associated with typical morphological elements revealed with advanced image processing technologies are very important to confirm the impact origin for many potential craters. The basic hypothesis of the impact-explosive tectonics [4] is that meteorite craters on the

  18. Entanglement typicality

    Science.gov (United States)

    Dahlsten, Oscar C. O.; Lupo, Cosmo; Mancini, Stefano; Serafini, Alessio

    2014-09-01

    We provide a summary of both seminal and recent results on typical entanglement. By ‘typical’ values of entanglement, we refer here to values of entanglement quantifiers that (given a reasonable measure on the manifold of states) appear with arbitrarily high probability for quantum systems of sufficiently high dimensionality. We shall focus on pure states and work within the Haar measure framework for discrete quantum variables, where we report on results concerning the average von Neumann and linear entropies as well as arguments implying the typicality of such values in the asymptotic limit. We then proceed to discuss the generation of typical quantum states with random circuitry. Different phases of entanglement, and the connection between typical entanglement and thermodynamics are discussed. We also cover approaches to measures on the non-compact set of Gaussian states of continuous variable quantum systems.

  19. A Typical Path Model of Tracheobronchial Clearance of Inhaled Particles in Rats

    Science.gov (United States)

    2002-01-01

    A mathematical description of particle clearance from the ciliated conducting airways (tracheobronchial region) of the lungs in rats was developed...particle transport velocities for given generations of airways were estimated from reported tracheal transport velocities. Using typical rat airway geometry...and estimated particle transport velocities solutions of sets of rate equations for transport from each generation of airways were summed to estimate

  20. Typical Protectionism

    Institute of Scientific and Technical Information of China (English)

    ZHANG ZHIPING

    2010-01-01

    @@ In the middle of October,acting on a complaint from the United Steelworkers union,the Office of the U.S.Trade Representative initiated a Section 301 investigation into China's clean energy policies and practices.The move has aroused strong opposition from China.China's New Energy Association says the probe is neither well-founded nor responsible,and is typical trade protectionism.

  1. Adult-onset Alexander disease with typical "tadpole" brainstem atrophy and unusual bilateral basal ganglia involvement: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Sakoe Kumi

    2010-04-01

    Full Text Available Abstract Background Alexander disease (ALX is a rare neurological disorder characterized by white matter degeneration and cytoplasmic inclusions in astrocytes called Rosenthal fibers, labeled by antibodies against glial fibrillary acidic protein (GFAP. Three subtypes are distinguished according to age at onset: infantile (under age 2, juvenile (age 2 to 12 and adult (over age 12. Following the identification of heterozygous mutations in GFAP that cause this disease, cases of adult-onset ALX have been increasingly reported. Case Presentation We present a 60-year-old Japanese man with an unremarkable past and no family history of ALX. After head trauma in a traffic accident at the age of 46, his character changed, and dementia and dysarthria developed, but he remained independent. Spastic paresis and dysphagia were observed at age 57 and 59, respectively, and worsened progressively. Neurological examination at the age of 60 revealed dementia, pseudobulbar palsy, left-side predominant spastic tetraparesis, axial rigidity, bradykinesia and gaze-evoked nystagmus. Brain MRI showed tadpole-like atrophy of the brainstem, caused by marked atrophy of the medulla oblongata, cervical spinal cord and midbrain tegmentum, with an intact pontine base. Analysis of the GFAP gene revealed a heterozygous missense mutation, c.827G>T, p.R276L, which was already shown to be pathogenic in a case of pathologically proven hereditary adult-onset ALX. Conclusion The typical tadpole-like appearance of the brainstem is strongly suggestive of adult-onset ALX, and should lead to a genetic investigation of the GFAP gene. The unusual feature of this patient is the symmetrical involvement of the basal ganglia, which is rarely observed in the adult form of the disease. More patients must be examined to confirm, clinically and neuroradiologically, extrapyramidal involvement of the basal ganglia in adult-onset ALX.

  2. Effective cluster typical medium theory for the diagonal Anderson disorder model in one- and two-dimensions

    Science.gov (United States)

    Ekuma, Chinedu E.; Terletska, Hanna; Meng, Zi Yang; Moreno, Juana; Jarrell, Mark; Mahmoudian, Samiyeh; Dobrosavljević, Vladimir

    2014-07-01

    We develop a cluster typical medium theory to study localization in disordered electronic systems. Our formalism is able to incorporate non-local correlations beyond the local typical medium theory in a systematic way. The cluster typical medium theory utilizes the momentum-resolved typical density of states and hybridization function to characterize the localization transition. We apply the formalism to the Anderson model of localization in one- and two-dimensions. In one-dimension, we find that the critical disorder strength scales inversely with the linear cluster size with a power law, Wc ˜ (1/Lc)1/ν, whereas in two-dimensions, the critical disorder strength decreases logarithmically with the linear cluster size. Our results are consistent with previous numerical work and are in agreement with the one-parameter scaling theory.

  3. Modeling human operator involvement in robotic systems

    NARCIS (Netherlands)

    Wewerinke, P.H.

    1991-01-01

    A modeling approach is presented to describe complex manned robotic systems. The robotic system is modeled as a (highly) nonlinear, possibly time-varying dynamic system including any time delays in terms of optimal estimation, control and decision theory. The role of the human operator(s) is modeled

  4. Computational fluid dynamics modeling of rope-guided conveyances in two typical kinds of shaft layouts.

    Directory of Open Access Journals (Sweden)

    Renyuan Wu

    Full Text Available The behavior of rope-guided conveyances is so complicated that the rope-guided hoisting system hasn't been understood thoroughly so far. In this paper, with user-defined functions loaded, ANSYS FLUENT 14.5 was employed to simulate lateral motion of rope-guided conveyances in two typical kinds of shaft layouts. With rope-guided mine elevator and mine cages taken into account, results show that the lateral aerodynamic buffeting force is much larger than the Coriolis force, and the side aerodynamic force have the same order of magnitude as the Coriolis force. The lateral aerodynamic buffeting forces should also be considered especially when the conveyance moves along the ventilation air direction. The simulation shows that the closer size of the conveyances can weaken the transverse aerodynamic buffeting effect.

  5. Buried Waste Integrated Demonstration stakeholder involvement model

    Energy Technology Data Exchange (ETDEWEB)

    Kaupanger, R.M.; Kostelnik, K.M.; Milam, L.M.

    1994-04-01

    The Buried Waste Integrated Demonstration (BWID) is a program funded by the US Department of Energy (DOE) Office of Technology Development. BWID supports the applied research, development, demonstration, and evaluation of a suite of advanced technologies that together form a comprehensive remediation system for the effective and efficient remediation of buried waste. Stakeholder participation in the DOE Environmental Management decision-making process is critical to remediation efforts. Appropriate mechanisms for communication with the public, private sector, regulators, elected officials, and others are being aggressively pursued by BWID to permit informed participation. This document summarizes public outreach efforts during FY-93 and presents a strategy for expanded stakeholder involvement during FY-94.

  6. A Typical Model Audit Approach: Spreadsheet Audit Methodologies in the City of London

    CERN Document Server

    Croll, Grenville J

    2003-01-01

    Spreadsheet audit and review procedures are an essential part of almost all City of London financial transactions. Structured processes are used to discover errors in large financial spreadsheets underpinning major transactions of all types. Serious errors are routinely found and are fed back to model development teams generally under conditions of extreme time urgency. Corrected models form the essence of the completed transaction and firms undertaking model audit and review expose themselves to significant financial liability in the event of any remaining significant error. It is noteworthy that in the United Kingdom, the management of spreadsheet error is almost unheard of outside of the City of London despite the commercial ubiquity of the spreadsheet.

  7. A Structural Equation Model of the Writing Process in Typically-Developing Sixth Grade Children

    Science.gov (United States)

    Koutsoftas, Anthony D.; Gray, Shelley

    2013-01-01

    The purpose of this study was to evaluate how sixth grade children planned, translated, and revised written narrative stories using a task reflecting current instructional and assessment practices. A modified version of the Hayes and Flower (1980) writing process model was used as the theoretical framework for the study. Two hundred one…

  8. General model of wood in typical coupled tasks. Part I. – Phenomenological approach

    Directory of Open Access Journals (Sweden)

    Petr Koňas

    2008-01-01

    Full Text Available The main aim of this work is focused on FE modeling of wood structure. This task is conditioned mainly by different organized structures/regions (tissues, anomalies... and leads to homogenization process of multiphysics declaration of common scientific and engineering problems. The crucial role in this paper is played by derivation of coefficient form of general PDE which is solvable by nowadays numerical solvers. Generality of supposed model is given by wide range of coupled physical fields included in the model. Used approach summarizes and brings together models for various fields of matter and energy common in wood material in wood drying process, but is also suitable for a lot of different tasks of similar materials. Namely microwave drying of wood with orthotropic, visco-elastic material properties together with time, moisture and temperature dependency of structural strains by modified mechanical properties were included. Specific matrixes of elasticity for in­di­vi­dual fields were derived. Thermal field in wood was described by conduction type of spreading. Coupling of physical fields is based on diffusive character of temperature, moisture, static pressure fields movement.

  9. Structural Analysis of Cuban Typical Model of Telecommunication Self-Supporting Towers under Seismic Load

    Directory of Open Access Journals (Sweden)

    Patricia Martín Rodríguez

    2012-07-01

    Full Text Available Self-supporting lattice towers are slender structures with low damping and high flexibility. They are sensitive to dynamic loads such as wind and earthquake. In the West of Cuba, structures should be analyzed under extreme winds and seismic effects, which raised their frequency during 2010 year. Self-supporting towers do not have the same dynamic behavior as buildings under seismic loads. Their specific structure features are not developed at design seismic codes, for that reason it is necessary to study methods of seismic analysis for self-supporting towers. The methods selected in this research are Modal Analysis Method proposed by Cuban Seismic Code (NC-46:1999 and modal superposition lineal dynamic analysis named Time History. It was selected for the study two self-supporting towers designed in Cuba, Versalles Model (3-legged and Najasa Model (4-legged. Comparative analysis between both methods is realized with extreme values of internal forces at element towers.

  10. Numerical Investigations of Two Typical Unsteady Flows in Turbomachinery Using the Multi-Passage Model

    Science.gov (United States)

    Zhou, Di; Lu, Zhiliang; Guo, Tongqing; Shen, Ennan

    2016-06-01

    In this paper, the research on two types of unsteady flow problems in turbomachinery including blade flutter and rotor-stator interaction is made by means of numerical simulation. For the former, the energy method is often used to predict the aeroelastic stability by calculating the aerodynamic work per vibration cycle. The inter-blade phase angle (IBPA) is an important parameter in computation and may have significant effects on aeroelastic behavior. For the latter, the numbers of blades in each row are usually not equal and the unsteady rotor-stator interactions could be strong. An effective way to perform multi-row calculations is the domain scaling method (DSM). These two cases share a common point that the computational domain has to be extended to multi passages (MP) considering their respective features. The present work is aimed at modeling these two issues with the developed MP model. Computational fluid dynamics (CFD) technique is applied to resolve the unsteady Reynolds-averaged Navier-Stokes (RANS) equations and simulate the flow fields. With the parallel technique, the additional time cost due to modeling more passages can be largely decreased. Results are presented on two test cases including a vibrating rotor blade and a turbine stage.

  11. Development of Performance Models for a Typical Flexible Road Pavement in Nigeria

    Directory of Open Access Journals (Sweden)

    Adebayo Oladipo Owolabi

    2012-09-01

    Full Text Available The results of a study conducted to facilitate the development of road pavement performance models that are appropriate for Nigeria and similar developing countries andcould predict the rate of deterioration over their lifespan have been presented. Comprehensive investigations were carried out on the expressway linking Lagos (the economic nerve centre of Nigeria with Ibadan (the largest city in West Africa - apparently one of the most heavily trafficked roads in the country. Data relating to traffic characteristics, pavement condition ratings, distress types, pavement thickness, roughness index, rainfall and temperature, were collected. Models were developed to determine Pavement Condition Score (PCS and International Roughness Index (IRI. Stepwise Regression was used to analyse the data and quantify the impact of key input parameters on the PCS and IRI. Parameters such as depth of ruts and area of pot holes were found to be statistically significant in predicting PCS while number of patches, length of longitudinal cracks and depth of ruts were statistically significant in predicting IRI. The models can be used for planning road maintenance programs, thus minimizing the need for comprehensive data collection on pavement condition before the maintenance exercise, which is costly and time consuming.

  12. Exergoeconomic performance optimization for a steady-flow endoreversible refrigeration model including six typical cycles

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Lingen; Kan, Xuxian; Sun, Fengrui; Wu, Feng [College of Naval Architecture and Power, Naval University of Engineering, Wuhan 430033 (China)

    2013-07-01

    The operation of a universal steady flow endoreversible refrigeration cycle model consisting of a constant thermal-capacity heating branch, two constant thermal-capacity cooling branches and two adiabatic branches is viewed as a production process with exergy as its output. The finite time exergoeconomic performance optimization of the refrigeration cycle is investigated by taking profit rate optimization criterion as the objective. The relations between the profit rate and the temperature ratio of working fluid, between the COP (coefficient of performance) and the temperature ratio of working fluid, as well as the optimal relation between profit rate and the COP of the cycle are derived. The focus of this paper is to search the compromised optimization between economics (profit rate) and the utilization factor (COP) for endoreversible refrigeration cycles, by searching the optimum COP at maximum profit, which is termed as the finite-time exergoeconomic performance bound. Moreover, performance analysis and optimization of the model are carried out in order to investigate the effect of cycle process on the performance of the cycles using numerical example. The results obtained herein include the performance characteristics of endoreversible Carnot, Diesel, Otto, Atkinson, Dual and Brayton refrigeration cycles.

  13. Magnesium degradation influenced by buffering salts in concentrations typical of in vitro and in vivo models.

    Science.gov (United States)

    Agha, Nezha Ahmad; Feyerabend, Frank; Mihailova, Boriana; Heidrich, Stefanie; Bismayer, Ulrich; Willumeit-Römer, Regine

    2016-01-01

    Magnesium and its alloys have considerable potential for orthopedic applications. During the degradation process the interface between material and tissue is continuously changing. Moreover, too fast or uncontrolled degradation is detrimental for the outcome in vivo. Therefore in vitro setups utilizing physiological conditions are promising for the material/degradation analysis prior to animal experiments. The aim of this study is to elucidate the influence of inorganic salts contributing to the blood buffering capacity on degradation. Extruded pure magnesium samples were immersed under cell culture conditions for 3 and 10 days. Hank's balanced salt solution without calcium and magnesium (HBSS) plus 10% of fetal bovine serum (FBS) was used as the basic immersion medium. Additionally, different inorganic salts were added with respect to concentration in Dulbecco's modified Eagle's medium (DMEM, in vitro model) and human plasma (in vivo model) to form 12 different immersion media. Influences on the surrounding environment were observed by measuring pH and osmolality. The degradation interface was analyzed by electron-induced X-ray emission (EIXE) spectroscopy, including chemical-element mappings and electron microprobe analysis, as well as Fourier transform infrared reflection micro-spectroscopy (FTIR).

  14. Exergoeconomic performance optimization for a steady-flow endoreversible refrigeration model including six typical cycles

    Directory of Open Access Journals (Sweden)

    Lingen Chen, Xuxian Kan, Fengrui Sun, Feng Wu

    2013-01-01

    Full Text Available The operation of a universal steady flow endoreversible refrigeration cycle model consisting of a constant thermal-capacity heating branch, two constant thermal-capacity cooling branches and two adiabatic branches is viewed as a production process with exergy as its output. The finite time exergoeconomic performance optimization of the refrigeration cycle is investigated by taking profit rate optimization criterion as the objective. The relations between the profit rate and the temperature ratio of working fluid, between the COP (coefficient of performance and the temperature ratio of working fluid, as well as the optimal relation between profit rate and the COP of the cycle are derived. The focus of this paper is to search the compromised optimization between economics (profit rate and the utilization factor (COP for endoreversible refrigeration cycles, by searching the optimum COP at maximum profit, which is termed as the finite-time exergoeconomic performance bound. Moreover, performance analysis and optimization of the model are carried out in order to investigate the effect of cycle process on the performance of the cycles using numerical example. The results obtained herein include the performance characteristics of endoreversible Carnot, Diesel, Otto, Atkinson, Dual and Brayton refrigeration cycles.

  15. Global Modeling of Nebulae with Particle Growth, Drift and Evaporation Fronts. I: Methodology and Typical Results

    CERN Document Server

    Estrada, Paul R; Morgan, Demitri A

    2015-01-01

    We model particle growth in a turbulent, viscously evolving protoplanetary nebula, incorporating sticking, bouncing, fragmentation, and mass transfer at high speeds. We treat small particles using a moments method and large particles using a traditional histogram binning, including a probability distribution function of collisional velocities. The fragmentation strength of the particles depends on their composition (icy aggregates are stronger than silicate aggregates). The particle opacity, which controls the nebula thermal structure, evolves as particles grow and mass redistributes. While growing, particles drift radially due to nebula headwind drag. Particles of different compositions evaporate at "evaporation fronts" (EFs) where the midplane temperature exceeds their respective evaporation temperatures. We track the vapor and solid phases of each component, accounting for advection and radial and vertical diffusion. We present characteristic results in evolutions lasting $2 \\times 10^5$ years. In general,...

  16. Magnesium degradation influenced by buffering salts in concentrations typical of in vitro and in vivo models

    Energy Technology Data Exchange (ETDEWEB)

    Agha, Nezha Ahmad; Feyerabend, Frank [Helmholtz-Zentrum Geesthacht, Institute of Material Research, Division of Metallic Biomaterials, Max-Planck-Str. 1, 21502 Geesthacht (Germany); Mihailova, Boriana; Heidrich, Stefanie; Bismayer, Ulrich [University of Hamburg, Department of Earth Sciences, Grindelallee 48, 20146 Hamburg (Germany); Willumeit-Römer, Regine [Helmholtz-Zentrum Geesthacht, Institute of Material Research, Division of Metallic Biomaterials, Max-Planck-Str. 1, 21502 Geesthacht (Germany)

    2016-01-01

    Magnesium and its alloys have considerable potential for orthopedic applications. During the degradation process the interface between material and tissue is continuously changing. Moreover, too fast or uncontrolled degradation is detrimental for the outcome in vivo. Therefore in vitro setups utilizing physiological conditions are promising for the material/degradation analysis prior to animal experiments. The aim of this study is to elucidate the influence of inorganic salts contributing to the blood buffering capacity on degradation. Extruded pure magnesium samples were immersed under cell culture conditions for 3 and 10 days. Hank's balanced salt solution without calcium and magnesium (HBSS) plus 10% of fetal bovine serum (FBS) was used as the basic immersion medium. Additionally, different inorganic salts were added with respect to concentration in Dulbecco's modified Eagle's medium (DMEM, in vitro model) and human plasma (in vivo model) to form 12 different immersion media. Influences on the surrounding environment were observed by measuring pH and osmolality. The degradation interface was analyzed by electron-induced X-ray emission (EIXE) spectroscopy, including chemical-element mappings and electron microprobe analysis, as well as Fourier transform infrared reflection micro-spectroscopy (FTIR). - Highlights: • Influence of blood buffering salts on magnesium degradation was studied. • CaCl{sub 2} reduced the degradation rate by Ca–PO{sub 4} layer formation. • MgSO{sub 4} influenced the morphology of the degradation interface. • NaHCO{sub 3} induced the formation of MgCO{sub 3} as a degradation product.

  17. Underlying Dynamics of Typical Fluctuations of an Emerging Market Price Index: The Heston Model from Minutes to Months

    CERN Document Server

    Vicente, R; Leite, V B P; Caticha, N; Vicente, Renato; Toledo, Charles M. de; Leite, Vitor B.P.; Caticha, Nestor

    2006-01-01

    We investigate the Heston model with stochastic volatility and exponential tails as a model for the typical price fluctuations of the Brazilian S\\~ao Paulo Stock Exchange Index (IBOVESPA). Raw prices are first corrected for inflation and a period spanning 15 years characterized by memoryless returns is chosen for the analysis. Model parameters are estimated by observing volatility scaling and correlation properties. We show that the Heston model with at least two time scales for the volatility mean reverting dynamics satisfactorily describes price fluctuations ranging from time scales larger than 20 minutes to 160 days. At time scales shorter than 20 minutes we observe autocorrelated returns and power law tails incompatible with the Heston model. Despite major regulatory changes, hyperinflation and currency crises experienced by the Brazilian market in the period studied, the general success of the description provided may be regarded as an evidence for a general underlying dynamics of price fluctuations at i...

  18. Techniques for mass resolution improvement achieved by typical plasma mass analyzers: Modeling and simulations

    Science.gov (United States)

    Nicolaou, Georgios; Yamauchi, Masatoshi; Wieser, Martin; Barabash, Stas; Fedorov, Andrei

    2016-04-01

    Mass separation and particularly distinction between atomic ions and molecular ions are essential in understanding a wide range of plasma environments, with each consisted of different species with various properties. In this study we present the optimization results of light-weight (about 2 kg) magnetic mass analyzers with high g-factor for Rosetta (Ion Composition Analyser: ICA) and for Mars Express and Venus Express (Ion Mass Analyser: IMA). For the instrument's optimization we use SIMION, a 3D ion tracing software in which we can trace particle beams of several energies and directions, passing through the instrument's units. We first reproduced ICA and IMA results, which turned out to be different from simple models for low energy (< 100 eV). We then change the mechanical structure of several units of the instrument and we quantify the new mass resolution achieved with each change. Our goal is to find the optimal instrument's structure, which will allow us to achieve a proper mass resolution to distinguish atomic nitrogen from atomic oxygen for the purposes of a future magnetospheric mission.

  19. GLOBAL MODELING OF NEBULAE WITH PARTICLE GROWTH, DRIFT, AND EVAPORATION FRONTS. I. METHODOLOGY AND TYPICAL RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Estrada, Paul R. [Carl Sagan Center, SETI Institute, 189 N. Bernardo Avenue # 100, Mountain View, CA 94043 (United States); Cuzzi, Jeffrey N. [Ames Research Center, NASA, Mail Stop 245-3, Moffett Field, CA 94035 (United States); Morgan, Demitri A., E-mail: Paul.R.Estrada@nasa.gov [USRA, NASA Ames Research Center, Mail Stop 245-3, Moffett Field, CA 94035 (United States)

    2016-02-20

    We model particle growth in a turbulent, viscously evolving protoplanetary nebula, incorporating sticking, bouncing, fragmentation, and mass transfer at high speeds. We treat small particles using a moments method and large particles using a traditional histogram binning, including a probability distribution function of collisional velocities. The fragmentation strength of the particles depends on their composition (icy aggregates are stronger than silicate aggregates). The particle opacity, which controls the nebula thermal structure, evolves as particles grow and mass redistributes. While growing, particles drift radially due to nebula headwind drag. Particles of different compositions evaporate at “evaporation fronts” (EFs) where the midplane temperature exceeds their respective evaporation temperatures. We track the vapor and solid phases of each component, accounting for advection and radial and vertical diffusion. We present characteristic results in evolutions lasting 2 × 10{sup 5} years. In general, (1) mass is transferred from the outer to the inner nebula in significant amounts, creating radial concentrations of solids at EFs; (2) particle sizes are limited by a combination of fragmentation, bouncing, and drift; (3) “lucky” large particles never represent a significant amount of mass; and (4) restricted radial zones just outside each EF become compositionally enriched in the associated volatiles. We point out implications for millimeter to submillimeter SEDs and the inference of nebula mass, radial banding, the role of opacity on new mechanisms for generating turbulence, the enrichment of meteorites in heavy oxygen isotopes, variable and nonsolar redox conditions, the primary accretion of silicate and icy planetesimals, and the makeup of Jupiter’s core.

  20. Global Modeling of Nebulae with Particle Growth, Drift, and Evaporation Fronts. I. Methodology and Typical Results

    Science.gov (United States)

    Estrada, Paul R.; Cuzzi, Jeffrey N.; Morgan, Demitri A.

    2016-02-01

    We model particle growth in a turbulent, viscously evolving protoplanetary nebula, incorporating sticking, bouncing, fragmentation, and mass transfer at high speeds. We treat small particles using a moments method and large particles using a traditional histogram binning, including a probability distribution function of collisional velocities. The fragmentation strength of the particles depends on their composition (icy aggregates are stronger than silicate aggregates). The particle opacity, which controls the nebula thermal structure, evolves as particles grow and mass redistributes. While growing, particles drift radially due to nebula headwind drag. Particles of different compositions evaporate at “evaporation fronts” (EFs) where the midplane temperature exceeds their respective evaporation temperatures. We track the vapor and solid phases of each component, accounting for advection and radial and vertical diffusion. We present characteristic results in evolutions lasting 2 × 105 years. In general, (1) mass is transferred from the outer to the inner nebula in significant amounts, creating radial concentrations of solids at EFs; (2) particle sizes are limited by a combination of fragmentation, bouncing, and drift; (3) “lucky” large particles never represent a significant amount of mass; and (4) restricted radial zones just outside each EF become compositionally enriched in the associated volatiles. We point out implications for millimeter to submillimeter SEDs and the inference of nebula mass, radial banding, the role of opacity on new mechanisms for generating turbulence, the enrichment of meteorites in heavy oxygen isotopes, variable and nonsolar redox conditions, the primary accretion of silicate and icy planetesimals, and the makeup of Jupiter’s core.

  1. The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model

    Directory of Open Access Journals (Sweden)

    Oytun Erbaş

    2013-09-01

    Full Text Available Objective: Antipsychotic drugs are known to have strongeffect on the bioelectric activity in the brain. However,some studies addressing the changes on electroencephalography(EEG caused by typical and atypical antipsychoticdrugs are conflicting. We aimed to compare the effectsof typical and atypical antipsychotics on the electricalactivity in the brain via EEG recordings in a rat model.Methods: Thirty-two Sprague Dawley adult male ratswere used in the study. The rats were divided into fivegroups, randomly (n=7, for each group. The first groupwas used as control group and administered 1 ml/kg salineintraperitoneally (IP. Haloperidol (1 mg/kg (group 2,chlorpromazine (5 mg/kg (group 3, olanzapine (1 mg/kg(group 4, ziprasidone (1 mg/ kg (group 5 were injectedIP for five consecutive days. Then, EEG recordings ofeach group were taken for 30 minutes.Results: The percentages of delta and theta waves inhaloperidol, chlorpromazine, olanzapine and ziprasidonegroups were found to have a highly significant differencecompared with the saline administration group (p<0.001.The theta waves in the olanzapine and ziprasidonegroups were increased compared with haloperidol andchlorpromazine groups (p<0.05.Conclusion: The typical and atypical antipsychotic drugsmay be risk factor for EEG abnormalities. This studyshows that antipsychotic drugs should be used with caution.J Clin Exp Invest 2013; 4 (3: 279-284Key words: Haloperidol, chlorpromazine, olanzapine,ziprasidone, EEG, rat

  2. A mathematical model for the performance assessment of engineering barriers of a typical near surface radioactive waste disposal facility

    Energy Technology Data Exchange (ETDEWEB)

    Antonio, Raphaela N.; Rotunno Filho, Otto C. [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia. Lab. de Hidrologia e Estudos do Meio Ambiente]. E-mail: otto@hidro.ufrj.br; Ruperti Junior, Nerbe J.; Lavalle Filho, Paulo F. Heilbron [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)]. E-mail: nruperti@cnen.gov.br

    2005-07-01

    This work proposes a mathematical model for the performance assessment of a typical radioactive waste disposal facility based on the consideration of a multiple barrier concept. The Generalized Integral Transform Technique is employed to solve the Advection-Dispersion mass transfer equation under the assumption of saturated one-dimensional flow, to obtain solute concentrations at given times and locations within the medium. A test-case is chosen in order to illustrate the performance assessment of several configurations of a multi barrier system adopted for the containment of sand contaminated with Ra-226 within a trench. (author)

  3. Underlying dynamics of typical fluctuations of an emerging market price index: The Heston model from minutes to months

    Science.gov (United States)

    Vicente, Renato; de Toledo, Charles M.; Leite, Vitor B. P.; Caticha, Nestor

    2006-02-01

    We investigate the Heston model with stochastic volatility and exponential tails as a model for the typical price fluctuations of the Brazilian São Paulo Stock Exchange Index (IBOVESPA). Raw prices are first corrected for inflation and a period spanning 15 years characterized by memoryless returns is chosen for the analysis. Model parameters are estimated by observing volatility scaling and correlation properties. We show that the Heston model with at least two time scales for the volatility mean reverting dynamics satisfactorily describes price fluctuations ranging from time scales larger than 20 min to 160 days. At time scales shorter than 20 min we observe autocorrelated returns and power law tails incompatible with the Heston model. Despite major regulatory changes, hyperinflation and currency crises experienced by the Brazilian market in the period studied, the general success of the description provided may be regarded as an evidence for a general underlying dynamics of price fluctuations at intermediate mesoeconomic time scales well approximated by the Heston model. We also notice that the connection between the Heston model and Ehrenfest urn models could be exploited for bringing new insights into the microeconomic market mechanics.

  4. A GIS-BASED DISTRIBUTED SOIL EROSION MODEL:A CASE STUDY OF TYPICAL WATERSHED, SICHUAN BASIN

    Institute of Scientific and Technical Information of China (English)

    Zaijian YUAN; Qiangguo CAI; Yingmin CHU

    2007-01-01

    Based on the measuring data and Digital Elevation Data (DEM) in a typical watershed--Hemingguan Watershed, Nanbu County, Sichuan Province of China, a GIS-based distributed soil erosion model was developed particularly for the purple soil type. It takes 20 m × 20 m grid as calculating unit and operates at 10-minute time interval. The required input data to the model include DEM, soil, land use, and time-series of precipitation and evaporation loss. The model enables one to estimate runoff, erosion and sediment yield for each grid cell and route the flow along its flow path to the watershed outlet. Furthermore, the model is capable of calculating the total runoff; erosion and sediment yield for the entire watershed by recursion algorithm. The validation of the model demonstrated that it could quantitatively simulate the spatial distribution of hydrological variables in a watershed, such as runoff, vegetation entrapment, soil erosion, the degree of soil and water loss. Moreover, it can evaluate the effect of land use change on the runoff generation and soil erosion with an accuracy of 80% and 75% respectively. The application of this model to a neighboring watershed with similar conditions indicates that this distributed model could be extended to other similar regions in China.

  5. Combinatorial Model Involving Stochastic Choices of Destination, Mode and Route

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Traffic assignment models are one of the basic tools for the analysis and design of transportation systems. However, the existing models have some defects. Considering the characteristics of Chinese urban mixed traffic and the randomness of transportation information, the author develops a combinatorial model involving stochastic choices of destination, mode and route. Its uniqueness and equivalance are also proved by the optimization theory.

  6. Using AGWA and the KINEROS2 Model-to-Model Green Infrastructure in Two Typical Residential Lots in Prescott, AZ

    Science.gov (United States)

    The Automated Geospatial Watershed Assessment (AGWA) Urban tool provides a step-by-step process to model subdivisions using the KINEROS2 model, with and without Green Infrastructure (GI) practices. AGWA utilizes the Kinematic Runoff and Erosion (KINEROS2) model, an event driven, ...

  7. Five challenges for stochastic epidemic models involving global transmission

    Directory of Open Access Journals (Sweden)

    Tom Britton

    2015-03-01

    Full Text Available The most basic stochastic epidemic models are those involving global transmission, meaning that infection rates depend only on the type and state of the individuals involved, and not on their location in the population. Simple as they are, there are still several open problems for such models. For example, when will such an epidemic go extinct and with what probability (questions depending on the population being fixed, changing or growing? How can a model be defined explaining the sometimes observed scenario of frequent mid-sized epidemic outbreaks? How can evolution of the infectious agent transmission rates be modelled and fitted to data in a robust way?

  8. Designing and testing lightweight shoulder prostheses with hybrid actuators for movements involved in typical activities of daily living and impact absorption

    Directory of Open Access Journals (Sweden)

    Sekine M

    2015-07-01

    Full Text Available Masashi Sekine,1,2 Kahori Kita,1 Wenwei Yu1 1Center for Frontier Medical Engineering, 2Graduate School of Engineering, Chiba University, Chiba, Japan Abstract: Unlike forearm amputees, transhumeral amputees have residual stumps that are too small to provide a sufficient range of operation for their prosthetic parts to perform usual activities of daily living. Furthermore, it is difficult for small residual stumps to provide sufficient impact absorption for safe manipulation in daily living, as intact arms do. Therefore, substitution of upper limb function in transhumeral amputees requires a sufficient range of motion and sufficient viscoelasticity for shoulder prostheses under critical weight and dimension constraints. We propose the use of two different types of actuators, ie, pneumatic elastic actuators (PEAs and servo motors. PEAs offer high power-to-weight performance and have intrinsic viscoelasticity in comparison with motors or standard industrial pneumatic cylinder actuators. However, the usefulness of PEAs in large working spaces is limited because of their short strokes. Servo motors, in contrast, can be used to achieve large ranges of motion. In this study, the relationship between the force and stroke of PEAs was investigated. The impact absorption of both types of actuators was measured using a single degree-of-freedom prototype to evaluate actuator compliance for safety purposes. Based on the fundamental properties of the actuators identified, a four degree-of-freedom robotic arm is proposed for prosthetic use. The configuration of the actuators and functional parts was designed to achieve a specified range of motion and torque calculated from the results of a simulation of typical movements performed in usual activities of daily living. Our experimental results showed that the requirements for the shoulder prostheses could be satisfied. Keywords: shoulder prosthesis, hybrid actuation, pneumatic elastic actuator, antagonistic

  9. A consumer involvement model for health technology assessment in Canada.

    Science.gov (United States)

    Pivik, Jayne; Rode, Elisabeth; Ward, Christopher

    2004-08-01

    Similar to other health policy initiatives, there is a growing movement to involve consumers in decisions affecting their treatment options. Access to treatments can be impacted by decisions made during a health technology assessment (HTA), i.e., the rigorous assessment of medical interventions such as drugs, vaccines, devices, materials, medical and surgical procedures and systems. The purpose of this paper was to empirically assess the interest and potential mechanisms for consumer involvement in HTA by identifying what health consumer organizations consider meaningful involvement, examining current practices internationally and developing a model for involvement based on identified priorities and needs. Canadian health consumer groups representing the largest disease or illness conditions reported a desire for involvement in HTA and provided feedback on mechanisms for facilitating their involvement.

  10. Causes and typical control model of wind-drift sandy lands in abandoned channel of the Yellow River

    Institute of Scientific and Technical Information of China (English)

    Zhang Guo-zhen; Yang Li; Xu Wei; Sun Bao-ping

    2006-01-01

    The historical formation and development of the abandoned channel of the Yellow River is reviewed and its causes of formation and present condition of prevention and control are analyzed in this paper. Based on this analysis, some ideas about control,critical problems and countermeasures in the next period are proposed with two typical control models as examples. We suggest that in preventing and controlling the wind-drift sandy lands in the region, the emphasis should be to develop, with a greatly expanded effort, a recycling economy. This should realize a combination of two ideas, i.e. integrate combating desertification with a structural adjustment of agricultural and an increase in the income of farmers.

  11. Identification of a Typical CSTR Using Optimal Focused Time Lagged Recurrent Neural Network Model with Gamma Memory Filter

    Directory of Open Access Journals (Sweden)

    S. N. Naikwad

    2009-01-01

    Full Text Available A focused time lagged recurrent neural network (FTLR NN with gamma memory filter is designed to learn the subtle complex dynamics of a typical CSTR process. Continuous stirred tank reactor exhibits complex nonlinear operations where reaction is exothermic. It is noticed from literature review that process control of CSTR using neuro-fuzzy systems was attempted by many, but optimal neural network model for identification of CSTR process is not yet available. As CSTR process includes temporal relationship in the input-output mappings, time lagged recurrent neural network is particularly used for identification purpose. The standard back propagation algorithm with momentum term has been proposed in this model. The various parameters like number of processing elements, number of hidden layers, training and testing percentage, learning rule and transfer function in hidden and output layer are investigated on the basis of performance measures like MSE, NMSE, and correlation coefficient on testing data set. Finally effects of different norms are tested along with variation in gamma memory filter. It is demonstrated that dynamic NN model has a remarkable system identification capability for the problems considered in this paper. Thus FTLR NN with gamma memory filter can be used to learn underlying highly nonlinear dynamics of the system, which is a major contribution of this paper.

  12. Transactional Models Between Personality and Alcohol Involvement: A Further Examination

    OpenAIRE

    2012-01-01

    Although correlated changes between personality and alcohol involvement have been shown, the functional relation between these constructs is also of theoretical and clinical interest. Using bivariate latent difference score models, we examined transactional relations (i.e., personality predicting changes in alcohol involvement, which in turn predicts changes in personality) across two distinct but overlapping developmental time frames (i.e., across college and during young adulthood) using tw...

  13. Coupling CFAST fire modeling and SAPHIRE probabilistic assessment software for internal fire safety evaluation of a typical TRIGA research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Safaei Arshi, Saiedeh [School of Engineering, Shiraz University, 71348-51154 Shiraz (Iran, Islamic Republic of); Nematollahi, Mohammadreza, E-mail: nema@shirazu.ac.i [School of Engineering, Shiraz University, 71348-51154 Shiraz (Iran, Islamic Republic of); Safety Research Center of Shiraz University, 71348-51154 Shiraz (Iran, Islamic Republic of); Sepanloo, Kamran [Safety Research Center of Shiraz University, 71348-51154 Shiraz (Iran, Islamic Republic of)

    2010-03-15

    Due to the significant threat of internal fires for the safety operation of nuclear reactors, presumed fire scenarios with potential hazards for loss of typical research reactor safety functions are analyzed by coupling CFAST fire modeling and SAPHIRE probabilistic assessment software. The investigations show that fire hazards associated with electrical cable insulation, lubricating oils, diesel, electrical equipment and carbon filters may lead to unsafe situations called core damage states. Using system-specific event trees, the occurrence frequency of core damage states after the occurrence of each possible fire scenario in critical fire compartments is evaluated. Probability that the fire ignited in the given fire compartment will burn long enough to cause the extent of damage defined by each fire scenario is calculated by means of detection-suppression event tree. As a part of detection-suppression event trees quantification, and also for generating the necessary input data for evaluating the frequency of core damage states by SAPHIRE 7.0 software, CFAST fire modeling software is applied. The results provide a probabilistic measure of the quality of existing fire protection systems in order to maintain the reactor at a reasonable safety level.

  14. Positive Solutions for a Competition Model with an Inhibitor Involved

    Institute of Scientific and Technical Information of China (English)

    Bin Chen

    2008-01-01

    In the paper, we study the positive solutions of a diffusive competition model with an inhibitor involved subject to the homogeneous Dirichlet boundary condition. The existence, uniqueness, stability and multiplicity of positive solutions are discussed. This is mainly done by using the local and global bifurcation theory.

  15. Evaluation of water conservation capacity of loess plateau typical mountain ecosystems based on InVEST model simulation

    Science.gov (United States)

    Lv, Xizhi; Zuo, Zhongguo; Xiao, Peiqing

    2017-06-01

    With increasing demand for water resources and frequently a general deterioration of local water resources, water conservation by forests has received considerable attention in recent years. To evaluate water conservation capacities of different forest ecosystems in mountainous areas of Loess Plateau, the landscape of forests was divided into 18 types in Loess Plateau. Under the consideration of the factors such as climate, topography, plant, soil and land use, the water conservation of the forest ecosystems was estimated by means of InVEST model. The result showed that 486417.7 hm2 forests in typical mountain areas were divided into 18 forest types, and the total water conservation quantity was 1.64×1012m3, equaling an average of water conversation quantity of 9.09×1010m3. There is a great difference in average water conversation capacity among various forest types. The water conservation function and its evaluation is crucial and complicated issues in the study of ecological service function in modern times.

  16. A Process Model of Organizational Commitment and Job Involvement.

    Science.gov (United States)

    1982-09-01

    AD-A123 043 A PROCESS MODEL OF ORGANIZATIONAL COMMITMENT AND JOB I INVOLVEMENT(U) AIR FORCE INST OF TECH WR IGHT PATTERSON AFB OH SCHOL OF SYSTEMS...Appo @1 inu pubo 01004 Aocesston For NTIS CRA&I DTIC TAB Unannounced 0I Justfication - gI, Distr" ’ut ioi / Af t A PROCESS MODEL OF ORGANIZATIONAL...GOVT ACCESSION NO. 3. RECIPIENT’S CATALOG NUMBER LSSR 76-82 1,3b - 4. TITLE (and Subtitle) S. TYPE OF REPORT & PERIOD COVERED A PROCESS MODEL OF

  17. Environmental Management Model for Road Maintenance Operation Involving Community Participation

    Science.gov (United States)

    Triyono, A. R. H.; Setyawan, A.; Sobriyah; Setiono, P.

    2017-07-01

    Public expectations of Central Java, which is very high on demand fulfillment, especially road infrastructure as outlined in the number of complaints and community expectations tweeter, Short Mail Massage (SMS), e-mail and public reports from various media, Highways Department of Central Java province requires development model of environmental management in the implementation of a routine way by involving the community in order to fulfill the conditions of a representative, may serve road users safely and comfortably. This study used survey method with SEM analysis and SWOT with Latent Independent Variable (X), namely; Public Participation in the regulation, development, construction and supervision of road (PSM); Public behavior in the utilization of the road (PMJ) Provincial Road Service (PJP); Safety in the Provincial Road (KJP); Integrated Management System (SMT) and latent dependent variable (Y) routine maintenance of the provincial road that is integrated with the environmental management system and involve the participation of the community (MML). The result showed the implementation of routine maintenance of road conditions in Central Java province has yet to implement an environmental management by involving the community; Therefore developed environmental management model with the results of H1: Community Participation (PSM) has positive influence on the Model of Environmental Management (MML); H2: Behavior Society in Jalan Utilization (PMJ) positive effect on Model Environmental Management (MML); H3: Provincial Road Service (PJP) positive effect on Model Environmental Management (MML); H4: Safety in the Provincial Road (KJP) positive effect on Model Environmental Management (MML); H5: Integrated Management System (SMT) has positive influence on the Model of Environmental Management (MML). From the analysis obtained formulation model describing the relationship / influence of the independent variables PSM, PMJ, PJP, KJP, and SMT on the dependent variable

  18. Involving stakeholders in building integrated fisheries models using Bayesian methods.

    Science.gov (United States)

    Haapasaari, Päivi; Mäntyniemi, Samu; Kuikka, Sakari

    2013-06-01

    A participatory Bayesian approach was used to investigate how the views of stakeholders could be utilized to develop models to help understand the Central Baltic herring fishery. In task one, we applied the Bayesian belief network methodology to elicit the causal assumptions of six stakeholders on factors that influence natural mortality, growth, and egg survival of the herring stock in probabilistic terms. We also integrated the expressed views into a meta-model using the Bayesian model averaging (BMA) method. In task two, we used influence diagrams to study qualitatively how the stakeholders frame the management problem of the herring fishery and elucidate what kind of causalities the different views involve. The paper combines these two tasks to assess the suitability of the methodological choices to participatory modeling in terms of both a modeling tool and participation mode. The paper also assesses the potential of the study to contribute to the development of participatory modeling practices. It is concluded that the subjective perspective to knowledge, that is fundamental in Bayesian theory, suits participatory modeling better than a positivist paradigm that seeks the objective truth. The methodology provides a flexible tool that can be adapted to different kinds of needs and challenges of participatory modeling. The ability of the approach to deal with small data sets makes it cost-effective in participatory contexts. However, the BMA methodology used in modeling the biological uncertainties is so complex that it needs further development before it can be introduced to wider use in participatory contexts.

  19. Involving Stakeholders in Building Integrated Fisheries Models Using Bayesian Methods

    Science.gov (United States)

    Haapasaari, Päivi; Mäntyniemi, Samu; Kuikka, Sakari

    2013-06-01

    A participatory Bayesian approach was used to investigate how the views of stakeholders could be utilized to develop models to help understand the Central Baltic herring fishery. In task one, we applied the Bayesian belief network methodology to elicit the causal assumptions of six stakeholders on factors that influence natural mortality, growth, and egg survival of the herring stock in probabilistic terms. We also integrated the expressed views into a meta-model using the Bayesian model averaging (BMA) method. In task two, we used influence diagrams to study qualitatively how the stakeholders frame the management problem of the herring fishery and elucidate what kind of causalities the different views involve. The paper combines these two tasks to assess the suitability of the methodological choices to participatory modeling in terms of both a modeling tool and participation mode. The paper also assesses the potential of the study to contribute to the development of participatory modeling practices. It is concluded that the subjective perspective to knowledge, that is fundamental in Bayesian theory, suits participatory modeling better than a positivist paradigm that seeks the objective truth. The methodology provides a flexible tool that can be adapted to different kinds of needs and challenges of participatory modeling. The ability of the approach to deal with small data sets makes it cost-effective in participatory contexts. However, the BMA methodology used in modeling the biological uncertainties is so complex that it needs further development before it can be introduced to wider use in participatory contexts.

  20. Modeling supercritical fluid extraction process involving solute-solid interaction

    Energy Technology Data Exchange (ETDEWEB)

    Goto, M.; Roy, B. Kodama, A.; Hirose, T. [Kumamoto Univ., Kumamoto (Japan)

    1998-04-01

    Extraction or leaching of solute from natural solid material is a mass transfer process involving dissolution or release of solutes from a solid matrix. Interaction between the solute and solid matrix often influences the supercritical fluid extraction process. A model accounting for the solute-solid interaction as well as mass transfer is developed. The BET equation is used to incorporate the interaction and the solubility of solutes into the local equilibrium in the model. Experimental data for the supercritical extraction of essential oil and cuticular wax from peppermint leaves are successfully analyzed by the model. The effects of parameters on the extraction behavior are demonstrated to illustrate the concept of the model. 18 refs., 5 figs., 1 tab.

  1. Proposed best practice for projects that involve modelling and simulation.

    Science.gov (United States)

    O'Kelly, Michael; Anisimov, Vladimir; Campbell, Chris; Hamilton, Sinéad

    2017-03-01

    Modelling and simulation has been used in many ways when developing new treatments. To be useful and credible, it is generally agreed that modelling and simulation should be undertaken according to some kind of best practice. A number of authors have suggested elements required for best practice in modelling and simulation. Elements that have been suggested include the pre-specification of goals, assumptions, methods, and outputs. However, a project that involves modelling and simulation could be simple or complex and could be of relatively low or high importance to the project. It has been argued that the level of detail and the strictness of pre-specification should be allowed to vary, depending on the complexity and importance of the project. This best practice document does not prescribe how to develop a statistical model. Rather, it describes the elements required for the specification of a project and requires that the practitioner justify in the specification the omission of any of the elements and, in addition, justify the level of detail provided about each element. This document is an initiative of the Special Interest Group for modelling and simulation. The Special Interest Group for modelling and simulation is a body open to members of Statisticians in the Pharmaceutical Industry and the European Federation of Statisticians in the Pharmaceutical Industry. Examples of a very detailed specification and a less detailed specification are included as appendices. Copyright © 2016 John Wiley & Sons, Ltd.

  2. Mathematical modeling of variables involved in dissolution testing.

    Science.gov (United States)

    Gao, Zongming

    2011-11-01

    Dissolution testing is an important technique used for development and quality control of solid oral dosage forms of pharmaceutical products. However, the variability associated with this technique, especially with USP apparatuses 1 and 2, is a concern for both the US Food and Drug Administration and pharmaceutical companies. Dissolution testing involves a number of variables, which can be divided into four main categories: (1) analyst, (2) dissolution apparatus, (3) testing environment, and (4) sample. Both linear and nonlinear models have been used to study dissolution profiles, and various mathematical functions have been used to model the observed data. In this study, several variables, including dissolved gases in the dissolution medium, off-center placement of the test tablet, environmental vibration, and various agitation speeds, were modeled. Mathematical models including Higuchi, Korsmeyer-Peppas, Weibull, and the Noyes-Whitney equation were employed to study the dissolution profile of 10 mg prednisone tablets (NCDA #2) using the USP paddle method. The results showed that the nonlinear models (Korsmeyer-Peppas and Weibull) accurately described the entire dissolution profile. The results also showed that dissolution variables affected dissolution rate constants differently, depending on whether the tablets disintegrated or dissolved.

  3. Modeling the Maturation of Grip Selection Planning and Action Representation: Insights from Typical and Atypical Motor Development.

    Directory of Open Access Journals (Sweden)

    Ian eFuelscher

    2016-02-01

    Full Text Available We investigated the purported association between developmental changes in grip selection planning and improvements in an individual’s capacity to represent action at an internal level (i.e., motor imagery. Participants were groups of healthy children aged 6-7 years and 8-12 years respectively, while a group of adolescents (13-17 years and adults (18-34 years allowed for consideration of childhood development in the broader context of motor maturation. A group of children aged 8-12 years with probable DCD (pDCD was included as a reference group for atypical motor development. Participants’ proficiency to generate and/or engage internal action representations was inferred from performance on the hand rotation task, a well-validated measure of motor imagery. A grip selection task designed to elicit the end-state comfort (ESC effect provided a window into the integrity of grip selection planning. Consistent with earlier accounts, the efficiency of grip selection planning followed a non-linear developmental progression in neurotypical individuals. As expected, analysis confirmed that these developmental improvements were predicted by an increased capacity to generate and/or engage internal action representations. The profile of this association remained stable throughout the (typical developmental spectrum. These findings are consistent with computational accounts of action planning that argue that internal action representations are associated with the expression and development of grip selection planning across typical development. However, no such association was found for our sample of children with pDCD, suggesting that individuals with atypical motor skill may adopt an alternative, sub-optimal strategy to plan their grip selection compared to their same-age control peers.

  4. Modeling the Maturation of Grip Selection Planning and Action Representation: Insights from Typical and Atypical Motor Development

    Science.gov (United States)

    Fuelscher, Ian; Williams, Jacqueline; Wilmut, Kate; Enticott, Peter G.; Hyde, Christian

    2016-01-01

    We investigated the purported association between developmental changes in grip selection planning and improvements in an individual’s capacity to represent action at an internal level [i.e., motor imagery (MI)]. Participants were groups of healthy children aged 6–7 years and 8–12 years respectively, while a group of adolescents (13–17 years) and adults (18–34 years) allowed for consideration of childhood development in the broader context of motor maturation. A group of children aged 8–12 years with probable DCD (pDCD) was included as a reference group for atypical motor development. Participants’ proficiency to generate and/or engage internal action representations was inferred from performance on the hand rotation task, a well-validated measure of MI. A grip selection task designed to elicit the end-state comfort (ESC) effect provided a window into the integrity of grip selection planning. Consistent with earlier accounts, the efficiency of grip selection planning followed a non-linear developmental progression in neurotypical individuals. As expected, analysis confirmed that these developmental improvements were predicted by an increased capacity to generate and/or engage internal action representations. The profile of this association remained stable throughout the (typical) developmental spectrum. These findings are consistent with computational accounts of action planning that argue that internal action representations are associated with the expression and development of grip selection planning across typical development. However, no such association was found for our sample of children with pDCD, suggesting that individuals with atypical motor skill may adopt an alternative, sub-optimal strategy to plan their grip selection compared to their same-age control peers. PMID:26903915

  5. [Adaptability analysis of FAO Penman-Monteith model over typical underlying surfaces in the Sanjiang Plain, Northeast China].

    Science.gov (United States)

    Jia, Zhi-Jun; Han, Lin; Wang, Ge; Zhang, Tong-Shun

    2014-05-01

    It is very important for studying surface energy and water balance to improve the accuracy of evapotranspiration (ET) estimation. Based on eddy covariance measurements and microclimate observational data available, comparisons were done in accuracy of simulating ET with the FAO Penman-Monteith model from the marshland, rice paddy and soybean field in the Sanjiang Plain. The results showed that the values of ET simulated with the model over marshland was significantly higher than the measured one (averagely 81.8% higher) when the crop coefficients recommend by FAO were adopted, and its modeling efficiency was negative, which indicated that the ET from the marshland couldn' t be simulated by the model. While the seasonal variation of ET over rice paddy and soybean field could be simulated by the model and the accuracy in simulating ET from rice paddy was better than that from soybean field. Crop coefficients (Kc) of marshland, rice paddy and soybean field were all significantly positively related to leaf area index, and crop coefficient of soybean field was also significantly negatively related to vapor pressure deficit. With Kc modified through linear regression, the FAO Penman-Monteith model markedly improved the estimation accuracy for marshland, rice paddy and soybean field, with the mean bias error ranging from -0.1 to 0.3 mm x d(-1), root mean square error ranging from 0.50 to 0.67 mm x d(-1) and modeling efficiency ranging from 0.69 to 0.85. Still, the accuracy in simulating ET from rice paddy was superior to that from the other two underlying surfaces. The FAO Penman-Monteith model was suitable to simulate the ET from rice paddy whether the crop coefficient was modified or not. However, the crop coefficient must be modified if the model was used to simulate the ET from marshland and soybean field.

  6. High-resolution modeling of the cusp density anomaly: Response to particle and Joule heating under typical conditions

    Science.gov (United States)

    Brinkman, Douglas G.; Walterscheid, Richard L.; Clemmons, James H.; Hecht, James. H.

    2016-03-01

    An established high-resolution dynamical model is employed to understand the behavior of the thermosphere beneath the Earth's magnetic cusps, with emphasis on the factors contributing to the density structures observed by the CHAMP and Streak satellite missions. In contrast to previous modeling efforts, this approach combines first principles dynamical modeling with the high spatial resolution needed to describe accurately mesoscale features such as the cusp. The resulting density structure is shown to be consistent with observations, including regions of both enhanced and diminished neutral density along the satellite track. This agreement is shown to be the result of a straightforward application of input conditions commonly found in the cusp rather than exaggerated or extreme conditions. It is found that the magnitude of the density change is sensitive to the width of the cusp region and that models that can resolve widths on the order of 2° of latitude are required to predict density variations that are consistent with the observations.

  7. Identification of a Typical CSTR Using Optimal Focused Time Lagged Recurrent Neural Network Model with Gamma Memory Filter

    National Research Council Canada - National Science Library

    Naikwad, S. N; Dudul, S. V

    2009-01-01

    .... It is noticed from literature review that process control of CSTR using neuro-fuzzy systems was attempted by many, but optimal neural network model for identification of CSTR process is not yet available...

  8. Research on the recycling industry development model for typical exterior plastic components of end-of-life passenger vehicle based on the SWOT method.

    Science.gov (United States)

    Zhang, Hongshen; Chen, Ming

    2013-11-01

    In-depth studies on the recycling of typical automotive exterior plastic parts are significant and beneficial for environmental protection, energy conservation, and sustainable development of China. In the current study, several methods were used to analyze the recycling industry model for typical exterior parts of passenger vehicles in China. The strengths, weaknesses, opportunities, and challenges of the current recycling industry for typical exterior parts of passenger vehicles were analyzed comprehensively based on the SWOT method. The internal factor evaluation matrix and external factor evaluation matrix were used to evaluate the internal and external factors of the recycling industry. The recycling industry was found to respond well to all the factors and it was found to face good developing opportunities. Then, the cross-link strategies analysis for the typical exterior parts of the passenger car industry of China was conducted based on the SWOT analysis strategies and established SWOT matrix. Finally, based on the aforementioned research, the recycling industry model led by automobile manufacturers was promoted.

  9. Extracting topographic characteristics of landforms typical of Canadian agricultural landscapes for agri-environmental modeling. I. Methodology

    NARCIS (Netherlands)

    Li, S.; Lobb, D.A.; McConkey, B.G.; MacMillan, R.A.; Moulin, A.; Fraser, W.R.

    2011-01-01

    Soil and topographic information are key inputs for many agri-environmental models and there are linkages between soil and topography at the Field scale. A major source of soil data is soil databases established based on field soil survey. Although both soil and topographic information are recorded

  10. [Effect of a model of the H-component of a typical magnetic storm on early ontogenesis in Daphnia magna Straus].

    Science.gov (United States)

    Krylov, V V; Zotov, O D; Osipova, E A; Znobishcheva, A V; Demtsun, N A

    2010-01-01

    The effect of a model of the H-component of a typical magnetic storm on the early ontogenesis of Daphnia magna Straus at 21 and 23 degrees C has been studied. It was shown based on the rates of the early ontogenesis that the effects of the model magnetic storm from the sudden onset of the storm to its end differ from the effects of the model magnetic storm from the recovery phase to the end of the storm. The effects of the model magnetic storm depended on temperature. The action of the model magnetic storm from the sudden onset of the storm to its end led to changes in the body length in the first progeny broods.

  11. The Optimal Price Ratio of Typical Energy Sources in Beijing Based on the Computable General Equilibrium Model

    Directory of Open Access Journals (Sweden)

    Yongxiu He

    2014-04-01

    Full Text Available In Beijing, China, the rational consumption of energy is affected by the insufficient linkage mechanism of the energy pricing system, the unreasonable price ratio and other issues. This paper combines the characteristics of Beijing’s energy market, putting forward the society-economy equilibrium indicator R maximization taking into consideration the mitigation cost to determine a reasonable price ratio range. Based on the computable general equilibrium (CGE model, and dividing four kinds of energy sources into three groups, the impact of price fluctuations of electricity and natural gas on the Gross Domestic Product (GDP, Consumer Price Index (CPI, energy consumption and CO2 and SO2 emissions can be simulated for various scenarios. On this basis, the integrated effects of electricity and natural gas price shocks on the Beijing economy and environment can be calculated. The results show that relative to the coal prices, the electricity and natural gas prices in Beijing are currently below reasonable levels; the solution to these unreasonable energy price ratios should begin by improving the energy pricing mechanism, through means such as the establishment of a sound dynamic adjustment mechanism between regulated prices and market prices. This provides a new idea for exploring the rationality of energy price ratios in imperfect competitive energy markets.

  12. Effectiveness of Peer Education Involving the use of Theoretical Models

    OpenAIRE

    2008-01-01

    The effectiveness of health education among university students who received peer-support training was investigated using four theoretical models : the health belief model, the self-efficacy model, social support and the transtheoretical model of health behavior change. Results suggested that the four theoretical models were useful in evaluating the effect of peer education as an alternative assessment tool. In light of this, it is suggested that the use of the theoretical models may facilita...

  13. Lithium-ion batteries modeling involving fractional differentiation

    Science.gov (United States)

    Sabatier, Jocelyn; Merveillaut, Mathieu; Francisco, Junior Mbala; Guillemard, Franck; Porcelatto, Denis

    2014-09-01

    With hybrid and electric vehicles development, automobile battery monitoring systems (BMS) have to meet the new requirements. These systems have to give information on state of health, state of charge, available power. To get this information, BMS often implement battery models. Accuracy of the information manipulated by the BMS thus depends on the model accuracy. This paper is within this framework and addresses lithium-ion battery modeling. The proposed fractional model is based on simplifications of an electrochemical model and on resolution of some partial differential equations used in its description. Such an approach permits to get a simple model in which electrochemical variables and parameters still appear.

  14. Dispersion modelling approaches for near road applications involving noise barriers

    Science.gov (United States)

    The talk will present comparisons with two datasets of the barrier algorithms implemented in two different dispersion models: US EPA’s R-LINE (a research dispersion modelling tool under development by the US EPA’s Office of Research and Development) and CERC’s A...

  15. Mouse models for genes involved in impaired spermatogenesis.

    Science.gov (United States)

    O'Bryan, M K; de Kretser, D

    2006-02-01

    Since the introduction of molecular biology and gene ablation technologies there have been substantial advances in our understanding of how sperm are made and fertilization occurs. There have been at least 150 different models of specifically altered gene function produced that have resulted in male infertility spanning virtually all aspects of the spermatogenic, sperm maturation and fertilization processes. While each has, or potentially will reveal, novel aspects of these processes, there is still much of which we have little knowledge. The current review is by no means a comprehensive list of these mouse models, rather it gives an overview of the potential for such models which up to this point have generally been 'knockouts'; it presents alternative strategies for the production of new models and emphasizes the importance of thorough phenotypic analysis in order to extract a maximum amount of information from each model.

  16. Pedigree models for complex human traits involving the mitochrondrial genome

    Energy Technology Data Exchange (ETDEWEB)

    Schork, N.J.; Guo, S.W. (Univ. of Michigan, Ann Arbor, MI (United States))

    1993-12-01

    Recent biochemical and molecular-genetic discoveries concerning variations in human mtDNA have suggested a role for mtDNA mutations in a number of human traits and disorders. Although the importance of these discoveries cannot be emphasized enough, the complex natures of mitochondrial biogenesis, mutant mtDNA phenotype expression, and the maternal inheritance pattern exhibited by mtDNA transmission make it difficult to develop models that can be used routinely in pedigree analyses to quantify and test hypotheses about the role of mtDNA in the expression of a trait. In the present paper, the authors describe complexities inherent in mitochondrial biogenesis and genetic transmission and show how these complexities can be incorporated into appropriate mathematical models. The authors offer a variety of likelihood-based models which account for the complexities discussed. The derivation of the models is meant to stimulate the construction of statistical tests for putative mtDNA contribution to a trait. Results of simulation studies which make use of the proposed models are described. The results of the simulation studies suggest that, although pedigree models of mtDNA effects can be reliable, success in mapping chromosomal determinants of a trait does not preclude the possibility that mtDNA determinants exist for the trait as well. Shortcomings inherent in the proposed models are described in an effort to expose areas in need of additional research. 58 refs., 5 figs., 2 tabs.

  17. A COUPLED MORPHODYNAMIC MODEL FOR APPLICATIONS INVOLVING WETTING AND DRYING*

    Institute of Scientific and Technical Information of China (English)

    LIANG Qiuhua

    2011-01-01

    This work presents a new finite volume Godunov-type model for predicting morphological changes under the rapidly varying flood conditions with wetting and drying. The model solves the coupled shallow water and Exner equations, with the interface fluxes evaluated by an Harten-Lax-van Leer-Contact (HLLC) approximate Riemann solver. Well-balanced solution is achieved using the surface gradient method and wetting and drying are handled by a non-negative reconstruction approach. The new model is validated against several theoretical benchmark tests and promising results are obtained.

  18. Modeling and Compensatory Processes Underlying Involvement in Child Care among Kibbutz-Reared Fathers

    Science.gov (United States)

    Gaunt, Ruth; Bassi, Liat

    2012-01-01

    This study examined modeling and compensatory processes underlying the effects of an early paternal model on father involvement in child care. Drawing on social learning theory, it was hypothesized that father-son relationships would moderate the association between a father's involvement and his own father's involvement. A sample of 136 kibbutz…

  19. Semi-Implicit Algorithm for Elastoplastic Damage Models Involving Energy Integration

    Directory of Open Access Journals (Sweden)

    Ji Zhang

    2016-01-01

    Full Text Available This study aims to develop a semi-implicit constitutive integration algorithm for a class of elastoplastic damage models where calculation of damage energy release rates involves integration of free energy. The constitutive equations with energy integration are split into the elastic predictor, plastic corrector, and damage corrector. The plastic corrector is solved with an improved format of the semi-implicit spectral return mapping, which is characterized by constant flow direction and plastic moduli calculated at initial yield, enforcement of consistency at the end, and coordinate-independent formulation with an orthogonally similar stress tensor. The tangent stiffness consistent with the updating algorithm is derived. The algorithm is implemented with a recently proposed elastoplastic damage model for concrete, and several typical mechanical tests of reinforced concrete components are simulated. The present semi-implicit algorithm proves to achieve a balance between accuracy, stability, and efficiency compared with the implicit and explicit algorithms and calculate free energy accurately with small time steps.

  20. Modeling of nonlinear responses for reciprocal transducers involving polarization switching

    DEFF Research Database (Denmark)

    Willatzen, Morten; Wang, Linxiang

    2007-01-01

    Nonlinearities and hysteresis effects in a reciprocal PZT transducer are examined by use of a dynamical mathematical model on the basis of phase-transition theory. In particular, we consider the perovskite piezoelectric ceramic in which the polarization process in the material can be modeled....... We present numerical results for the reciprocal-transducer system and identify the influence of nonlinearities on the system dynamics at high and low frequency as well as electrical impedance effects due to tuning by a series inductance. It is found that nonlinear effects are not important at high...... by Landau theory for the first-order phase transformation, in which each polarization state is associated with a minimum of the Landau free-energy function. Nonlinear constitutive laws are obtained by using thermodynamical equilibrium conditions, and hysteretic behavior of the material can be modeled...

  1. The Coriolis Effect: A Model for Student Involvement

    Science.gov (United States)

    Exline, Joseph D.

    1977-01-01

    Lists materials and procedures for constructing a model that demonstrates certain aspects of the Coriolis effect. Materials include an electric drill motor, voltage control, toy dart gun and darts, wood blocks of varying dimensions. Includes description of an experiment illustrating relationship between speed of rotation and amount of apparent…

  2. Mechanism involved in the UCB neurotoxicity on cellular models

    OpenAIRE

    Giraudi, Pablo Jose'

    2009-01-01

    Summary This doctoral thesis covers three years period (2006-2008) during which I have investigated the bilirubin neurotoxicity in the neuroblastoma SH-SY5Y cell line, a neuronal cell model widely used in the study of the pathogenesis and in the development of new therapeutic compounds for neurodegenerative diseases. In the first chapter is summarized the current knowledge about bilirubin chemistry and metabolism including disorders of bilirubin metabolism and the neuronal disturbanc...

  3. Typicals/Típicos

    Directory of Open Access Journals (Sweden)

    Silvia Vélez

    2004-01-01

    Full Text Available Typicals is a series of 12 colour photographs digitally created from photojournalistic images from Colombia combined with "typical" craft textiles and text from guest writers. Typicals was first exhibited as photographs 50cm x 75cm in size, each with their own magnifying glass, at the Contemporary Art Space at Gorman House in Canberra, Australia, in 2000. It was then exhibited in "Feedback: Art Social Consciousness and Resistance" at Monash University Museum of Art in Melbourne, Australia, from March to May 2003. From May to June 2003 it was exhibited at the Museo de Arte de la Universidad Nacional de Colombia Santa Fé Bogotá, Colombia. In its current manifestation the artwork has been adapted from the catalogue of the museum exhibitions. It is broken up into eight pieces corresponding to the contributions of the writers. The introduction by Sylvia Vélez is the PDF file accessible via a link below this abstract. The other seven PDF files are accessible via the 'Research Support Tool' section to the right of your screen. Please click on 'Supp. Files'. Please note that these files are around 4 megabytes each, so it may be difficult to access them from a dial-up connection.

  4. Sleeping Beauty mouse models identify candidate genes involved in gliomagenesis.

    Science.gov (United States)

    Vyazunova, Irina; Maklakova, Vilena I; Berman, Samuel; De, Ishani; Steffen, Megan D; Hong, Won; Lincoln, Hayley; Morrissy, A Sorana; Taylor, Michael D; Akagi, Keiko; Brennan, Cameron W; Rodriguez, Fausto J; Collier, Lara S

    2014-01-01

    Genomic studies of human high-grade gliomas have discovered known and candidate tumor drivers. Studies in both cell culture and mouse models have complemented these approaches and have identified additional genes and processes important for gliomagenesis. Previously, we found that mobilization of Sleeping Beauty transposons in mice ubiquitously throughout the body from the Rosa26 locus led to gliomagenesis with low penetrance. Here we report the characterization of mice in which transposons are mobilized in the Glial Fibrillary Acidic Protein (GFAP) compartment. Glioma formation in these mice did not occur on an otherwise wild-type genetic background, but rare gliomas were observed when mobilization occurred in a p19Arf heterozygous background. Through cloning insertions from additional gliomas generated by transposon mobilization in the Rosa26 compartment, several candidate glioma genes were identified. Comparisons to genetic, epigenetic and mRNA expression data from human gliomas implicates several of these genes as tumor suppressor genes and oncogenes in human glioblastoma.

  5. Evaluation of the AnnAGNPS Model for Predicting Runoff and Nutrient Export in a Typical Small Watershed in the Hilly Region of Taihu Lake

    Directory of Open Access Journals (Sweden)

    Chuan Luo

    2015-09-01

    Full Text Available The application of hydrological and water quality models is an efficient approach to better understand the processes of environmental deterioration. This study evaluated the ability of the Annualized Agricultural Non-Point Source (AnnAGNPS model to predict runoff, total nitrogen (TN and total phosphorus (TP loading in a typical small watershed of a hilly region near Taihu Lake, China. Runoff was calibrated and validated at both an annual and monthly scale, and parameter sensitivity analysis was performed for TN and TP before the two water quality components were calibrated. The results showed that the model satisfactorily simulated runoff at annual and monthly scales, both during calibration and validation processes. Additionally, results of parameter sensitivity analysis showed that the parameters Fertilizer rate, Fertilizer organic, Canopy cover and Fertilizer inorganic were more sensitive to TN output. In terms of TP, the parameters Residue mass ratio, Fertilizer rate, Fertilizer inorganic and Canopy cover were the most sensitive. Based on these sensitive parameters, calibration was performed. TN loading produced satisfactory results for both the calibration and validation processes, whereas the performance of TP loading was slightly poor. The simulation results showed that AnnAGNPS has the potential to be used as a valuable tool for the planning and management of watersheds.

  6. Sleeping Beauty mouse models identify candidate genes involved in gliomagenesis.

    Directory of Open Access Journals (Sweden)

    Irina Vyazunova

    Full Text Available Genomic studies of human high-grade gliomas have discovered known and candidate tumor drivers. Studies in both cell culture and mouse models have complemented these approaches and have identified additional genes and processes important for gliomagenesis. Previously, we found that mobilization of Sleeping Beauty transposons in mice ubiquitously throughout the body from the Rosa26 locus led to gliomagenesis with low penetrance. Here we report the characterization of mice in which transposons are mobilized in the Glial Fibrillary Acidic Protein (GFAP compartment. Glioma formation in these mice did not occur on an otherwise wild-type genetic background, but rare gliomas were observed when mobilization occurred in a p19Arf heterozygous background. Through cloning insertions from additional gliomas generated by transposon mobilization in the Rosa26 compartment, several candidate glioma genes were identified. Comparisons to genetic, epigenetic and mRNA expression data from human gliomas implicates several of these genes as tumor suppressor genes and oncogenes in human glioblastoma.

  7. Sleeping Beauty Mouse Models Identify Candidate Genes Involved in Gliomagenesis

    Science.gov (United States)

    Vyazunova, Irina; Maklakova, Vilena I.; Berman, Samuel; De, Ishani; Steffen, Megan D.; Hong, Won; Lincoln, Hayley; Morrissy, A. Sorana; Taylor, Michael D.; Akagi, Keiko; Brennan, Cameron W.; Rodriguez, Fausto J.; Collier, Lara S.

    2014-01-01

    Genomic studies of human high-grade gliomas have discovered known and candidate tumor drivers. Studies in both cell culture and mouse models have complemented these approaches and have identified additional genes and processes important for gliomagenesis. Previously, we found that mobilization of Sleeping Beauty transposons in mice ubiquitously throughout the body from the Rosa26 locus led to gliomagenesis with low penetrance. Here we report the characterization of mice in which transposons are mobilized in the Glial Fibrillary Acidic Protein (GFAP) compartment. Glioma formation in these mice did not occur on an otherwise wild-type genetic background, but rare gliomas were observed when mobilization occurred in a p19Arf heterozygous background. Through cloning insertions from additional gliomas generated by transposon mobilization in the Rosa26 compartment, several candidate glioma genes were identified. Comparisons to genetic, epigenetic and mRNA expression data from human gliomas implicates several of these genes as tumor suppressor genes and oncogenes in human glioblastoma. PMID:25423036

  8. Equilibrium models of coronal loops that involve curvature and buoyancy

    CERN Document Server

    Hindman, Bradley W

    2013-01-01

    We construct magnetostatic models of coronal loops in which the thermodynamics of the loop is fully consistent with the shape and geometry of the loop. This is achieved by treating the loop as a thin, compact, magnetic fibril that is a small departure from a force-free state. The density along the loop is related to the loop's curvature by requiring that the Lorentz force arising from this deviation is balanced by buoyancy. This equilibrium, coupled with hydrostatic balance and the ideal gas law, then connects the temperature of the loop with the curvature of the loop without resorting to a detailed treatment of heating and cooling. We present two example solutions: one with a spatially invariant magnetic Bond number (the dimensionless ratio of buoyancy to Lorentz forces) and the other with a constant radius of curvature of the loop's axis. We find that the density and temperature profiles are quite sensitive to curvature variations along the loop, even for loops with similar aspect ratios.

  9. Equilibrium Models of Coronal Loops That Involve Curvature and Buoyancy

    Science.gov (United States)

    Hindman, Bradley W.; Jain, Rekha

    2013-12-01

    We construct magnetostatic models of coronal loops in which the thermodynamics of the loop is fully consistent with the shape and geometry of the loop. This is achieved by treating the loop as a thin, compact, magnetic fibril that is a small departure from a force-free state. The density along the loop is related to the loop's curvature by requiring that the Lorentz force arising from this deviation is balanced by buoyancy. This equilibrium, coupled with hydrostatic balance and the ideal gas law, then connects the temperature of the loop with the curvature of the loop without resorting to a detailed treatment of heating and cooling. We present two example solutions: one with a spatially invariant magnetic Bond number (the dimensionless ratio of buoyancy to Lorentz forces) and the other with a constant radius of the curvature of the loop's axis. We find that the density and temperature profiles are quite sensitive to curvature variations along the loop, even for loops with similar aspect ratios.

  10. The independent spreaders involved SIR Rumor model in complex networks

    Science.gov (United States)

    Qian, Zhen; Tang, Shaoting; Zhang, Xiao; Zheng, Zhiming

    2015-07-01

    Recent studies of rumor or information diffusion process in complex networks show that in contrast to traditional comprehension, individuals who participate in rumor spreading within one network do not always get the rumor from their neighbors. They can obtain the rumor from different sources like online social networks and then publish it on their personal sites. In our paper, we discuss this phenomenon in complex networks by adopting the concept of independent spreaders. Rather than getting the rumor from neighbors, independent spreaders learn it from other channels. We further develop the classic "ignorant-spreaders-stiflers" or SIR model of rumor diffusion process in complex networks. A steady-state analysis is conducted to investigate the final spectrum of the rumor spreading under various spreading rate, stifling rate, density of independent spreaders and average degree of the network. Results show that independent spreaders effectively enhance the rumor diffusion process, by delivering the rumor to regions far away from the current rumor infected regions. And though the rumor spreading process in SF networks is faster than that in ER networks, the final size of rumor spreading in ER networks is larger than that in SF networks.

  11. A model of the supplier involvement in the product innovation

    Directory of Open Access Journals (Sweden)

    Kumar Manoj

    2017-01-01

    Full Text Available In this paper we examine the product innovation in a supply chain by a supplier and derive a model for a supplier’s product innovation policy. The product innovation of a supplier can contribute to the long-term competitiveness for the supply chain, and as it is for many supply chains a major factor, it should be considered in the development of strategies for a supplier. Here, we evaluate the effectiveness of supplier product innovation as a strategic tool to enhance the competitiveness and viability of supply chain. This paper explores the dynamic research performance of a supplier with endogenous time preference under a given arrangement of product innovation. We find that the optimal effort level and the achieved product innovation obey a saddle point path, or show tremendous fluctuations even without introducing the stochastic nature of product innovative activity. We also find that the fluctuation frequency is largely dependent both on the supplier’s characteristics such as supplier’s product innovative ability and on the nature of product innovation process per se. Short-run analyses are also made on the effect of supply chain cooperation in the product innovation process.

  12. Parents as Role Models: Parental Behavior Affects Adolescents' Plans for Work Involvement

    Science.gov (United States)

    Wiese, Bettina S.; Freund, Alexandra M.

    2011-01-01

    This study (N = 520 high-school students) investigates the influence of parental work involvement on adolescents' own plans regarding their future work involvement. As expected, adolescents' perceptions of parental work behavior affected their plans for own work involvement. Same-sex parents served as main role models for the adolescents' own…

  13. Sex-dependent antipsychotic capacity of 17β-estradiol in the latent inhibition model: a typical antipsychotic drug in both sexes, atypical antipsychotic drug in males.

    Science.gov (United States)

    Arad, Michal; Weiner, Ina

    2010-10-01

    The estrogen hypothesis of schizophrenia suggests that estrogen is a natural neuroprotector in women and that exogenous estrogen may have antipsychotic potential, but results of clinical studies have been inconsistent. We have recently shown using the latent inhibition (LI) model of schizophrenia that 17β-estradiol exerts antipsychotic activity in ovariectomized (OVX) rats. The present study sought to extend the characterization of the antipsychotic action of 17β-estradiol (10, 50 and 150 μg/kg) by testing its capacity to reverse amphetamine- and MK-801-induced LI aberrations in gonadally intact female and male rats. No-drug controls of both sexes showed LI, ie, reduced efficacy of a previously non-reinforced stimulus to gain behavioral control when paired with reinforcement, if conditioned with two but not five tone-shock pairings. In both sexes, amphetamine (1 mg/kg) and MK-801 (50 μg/kg) produced disruption (under weak conditioning) and persistence (under strong conditioning) of LI, modeling positive and negative/cognitive symptoms, respectively. 17β-estradiol at 50 and 150 μg/kg potentiated LI under strong conditioning and reversed amphetamine-induced LI disruption in both males and females, mimicking the action of typical and atypical antipsychotic drugs (APDs) in the LI model. 17β-estradiol also reversed MK-induced persistent LI, an effect mimicking atypical APDs and NMDA receptor enhancers, but this effect was observed in males and OVX females but not in intact females. These findings indicate that in the LI model, 17β-estradiol exerts a clear-cut antipsychotic activity in both sexes and, remarkably, is more efficacious in males and OVX females where it also exerts activity considered predictive of anti-negative/cognitive symptoms.

  14. Introducing an Intervention Model for Fostering Affective Involvement with Persons Who Are Congenitally Deafblind

    Science.gov (United States)

    Martens, Marga A. W.; Janssen, Marleen J.; Ruijssenaars, Wied A. J. J. M.; Riksen-Walraven, J. Marianne

    2014-01-01

    The article presented here introduces the Intervention Model for Affective Involvement (IMAI), which was designed to train staff members (for example, teachers, caregivers, support workers) to foster affective involvement during interaction and communication with persons who have congenital deaf-blindness. The model is theoretically underpinned,…

  15. Application of a modified distributed-dynamic erosion and sediment yield model in a typical watershed of a hilly and gully region, Chinese Loess Plateau

    Science.gov (United States)

    Wu, Lei; Liu, Xia; Ma, Xiaoyi

    2016-11-01

    Soil erosion not only results in the destruction of land resources and the decline of soil fertility, but also contributes to river channel sedimentation. In order to explore the spatiotemporal evolution of erosion and sediment yield before and after returning farmland in a typical watershed of the hilly and gully region (Chinese Loess Plateau), a distributed-dynamic model of sediment yield based on the Chinese Soil Loss Equation (CSLE) was established and modified to assess the effects of hydrological factors and human activities on erosion and sediment yield between 1995 and 2013. Results indicate that (1) the modified model has the characteristics of a simple algorithm, high accuracy, wide practicability and easy expansion, and can be applied to predict erosion and sediment yield in the study area, (2) soil erosion gradations are closely related to the spatial distribution of rainfall erosivity and land use patterns, and the current soil and water conservation measures are not efficient for high rainfall intensities, and (3) the average sediment yield rate before and after model modification in the most recent 5 years (in addition to 2013) is 4574.62 and 1696.1 Mg km-2, respectively, decreasing by about 35.4 and 78.2 % when compared to the early governance (1995-1998). However, in July 2013 the once-in-a-century storm is the most important reason for maximum sediment yield. Results may provide an effective and scientific basis for soil and water conservation planning and ecological construction of the hilly and gully region, Chinese Loess Plateau.

  16. A Typical Synergy

    Science.gov (United States)

    van Noort, Thomas; Achten, Peter; Plasmeijer, Rinus

    We present a typical synergy between dynamic types (dynamics) and generalised algebraic datatypes (GADTs). The former provides a clean approach to integrating dynamic typing in a statically typed language. It allows values to be wrapped together with their type in a uniform package, deferring type unification until run time using a pattern match annotated with the desired type. The latter allows for the explicit specification of constructor types, as to enforce their structural validity. In contrast to ADTs, GADTs are heterogeneous structures since each constructor type is implicitly universally quantified. Unfortunately, pattern matching only enforces structural validity and does not provide instantiation information on polymorphic types. Consequently, functions that manipulate such values, such as a type-safe update function, are cumbersome due to boilerplate type representation administration. In this paper we focus on improving such functions by providing a new GADT annotation via a natural synergy with dynamics. We formally define the semantics of the annotation and touch on novel other applications of this technique such as type dispatching and enforcing type equality invariants on GADT values.

  17. Modeling the fate of p,p'-DDT in water and sediment of two typical estuarine bays in South China: Importance of fishing vessels' inputs.

    Science.gov (United States)

    Fang, Shu-Ming; Zhang, Xianming; Bao, Lian-Jun; Zeng, Eddy Y

    2016-05-01

    Antifouling paint applied to fishing vessels is the primary source of dichloro-diphenyl-trichloroethane (DDT) to the coastal marine environments of China. With the aim to provide science-based support of potential regulations on DDT use in antifouling paint, we utilized a fugacity-based model to evaluate the fate and impact of p,p'-DDT, the dominant component of DDT mixture, in Daya Bay and Hailing Bay, two typical estuarine bays in South China. The emissions of p,p'-DDT from fishing vessels to the aquatic environments of Hailing Bay and Daya Bay were estimated as 9.3 and 7.7 kg yr(-1), respectively. Uncertainty analysis indicated that the temporal variability of p,p'-DDT was well described by the model if fishing vessels were considered as the only direct source, i.e., fishing vessels should be the dominant source of p,p'-DDT in coastal bay areas of China. Estimated hazard quotients indicated that sediment in Hailing Bay posed high risk to the aquatic system, and it would take at least 21 years to reduce the hazards to a safe level. Moreover, p,p'-DDT tends to migrate from water to sediment in the entire Hailing Bay and Daya Bay. On the other hand, our previous research indicated that p,p'-DDT was more likely to migrate from sediment to water in the maricultured zones located in shallow waters of these two bays, where fishing vessels frequently remain. These findings suggest that relocating mariculture zones to deeper waters would reduce the likelihood of farmed fish contamination by p,p'-DDT.

  18. Response surface modeling-based source contribution analysis and VOC emission control policy assessment in a typical ozone-polluted urban Shunde, China.

    Science.gov (United States)

    You, Zhiqiang; Zhu, Yun; Jang, Carey; Wang, Shuxiao; Gao, Jian; Lin, Che-Jen; Li, Minhui; Zhu, Zhenghua; Wei, Hao; Yang, Wenwei

    2017-01-01

    To develop a sound ozone (O3) pollution control strategy, it is important to well understand and characterize the source contribution due to the complex chemical and physical formation processes of O3. Using the "Shunde" city as a pilot summer case study, we apply an innovative response surface modeling (RSM) methodology based on the Community Multi-Scale Air Quality (CMAQ) modeling simulations to identify the O3 regime and provide dynamic analysis of the precursor contributions to effectively assess the O3 impacts of volatile organic compound (VOC) control strategy. Our results show that Shunde is a typical VOC-limited urban O3 polluted city. The "Jiangmen" city, as the main upper wind area during July 2014, its VOCs and nitrogen oxides (NOx) emissions make up the largest contribution (9.06%). On the contrary, the contribution from local (Shunde) emission is lowest (6.35%) among the seven neighbor regions. The local VOCs industrial source emission has the largest contribution comparing to other precursor emission sectors in Shunde. The results of dynamic source contribution analysis further show that the local NOx control could slightly increase the ground O3 under low (10.00%) and medium (40.00%) reduction ratios, while it could start to turn positive to decrease ground O3 under the high NOx abatement ratio (75.00%). The real-time assessment of O3 impacts from VOCs control strategies in Pearl River Delta (PRD) shows that the joint regional VOCs emission control policy will effectively reduce the ground O3 concentration in Shunde. Copyright © 2016. Published by Elsevier B.V.

  19. Typicality, graded membership, and vagueness.

    Science.gov (United States)

    Hampton, James A

    2007-05-01

    This paper addresses theoretical problems arising from the vagueness of language terms, and intuitions of the vagueness of the concepts to which they refer. It is argued that the central intuitions of prototype theory are sufficient to account for both typicality phenomena and psychological intuitions about degrees of membership in vaguely defined classes. The first section explains the importance of the relation between degrees of membership and typicality (or goodness of example) in conceptual categorization. The second and third section address arguments advanced by Osherson and Smith (1997), and Kamp and Partee (1995), that the two notions of degree of membership and typicality must relate to fundamentally different aspects of conceptual representations. A version of prototype theory-the Threshold Model-is proposed to counter these arguments and three possible solutions to the problems of logical selfcontradiction and tautology for vague categorizations are outlined. In the final section graded membership is related to the social construction of conceptual boundaries maintained through language use.

  20. Effects of deceptive packaging and product involvement on purchase intention: an elaboration likelihood model perspective.

    Science.gov (United States)

    Lammers, H B

    2000-04-01

    From an Elaboration Likelihood Model perspective, it was hypothesized that postexposure awareness of deceptive packaging claims would have a greater negative effect on scores for purchase intention by consumers lowly involved rather than highly involved with a product (n = 40). Undergraduates who were classified as either highly or lowly (ns = 20 and 20) involved with M&Ms examined either a deceptive or non-deceptive package design for M&Ms candy and were subsequently informed of the deception employed in the packaging before finally rating their intention to purchase. As anticipated, highly deceived subjects who were low in involvement rated intention to purchase lower than their highly involved peers. Overall, the results attest to the robustness of the model and suggest that the model has implications beyond advertising effects and into packaging effects.

  1. Typical Logistical Processes

    Directory of Open Access Journals (Sweden)

    Igor Trupac

    2012-10-01

    Full Text Available For modern global economic activity changes in the structureof goods, networks, technical and technological developmentand increased competence are significant, which requiresnew solutions and new mode of thinking.The competitive model which relied in the past on productinnovation will have to be largely supplemented by process innovationthat add greater value for customers. The basis forcompeting today and in the future will be competitive advantagewhich enhances product excellence as well as process excellence.

  2. Modeling the Relations among Parental Involvement, School Engagement and Academic Performance of High School Students

    Science.gov (United States)

    Al-Alwan, Ahmed F.

    2014-01-01

    The author proposed a model to explain how parental involvement and school engagement related to academic performance. Participants were (671) 9th and 10th graders students who completed two scales of "parental involvement" and "school engagement" in their regular classrooms. Results of the path analysis suggested that the…

  3. Love channel-waves dispersion characteristic analysis of typical coal models%典型含煤模型Love型槽波的频散特征分析

    Institute of Scientific and Technical Information of China (English)

    程建远; 姬广忠; 朱培民

    2012-01-01

    In order to study the dispersion characteristics of Love channel-waves under different geological conditions,four kinds models of 2D typical seismogeology were designed.There are various coal thickness models,different wall rock(high-velocity and low-velocity wall rock models)for which the coal thickness is stable as 10 m,coal models containing 5 m fault for which the coal thickness is 10 m,and coal imbedded by leat which sizes are 5 m×5 m,5 m×10 m,5 m×20 m and 5 m×50 m.These models were numerically simulated by SH wave equation.Analyzed the wave-fields characteristics of Love channel-waves and used Fourier transform on synthetic seismic records to obtain channel-waves dispersion curves;the results show that the coal thickness mainly influences energy distribution of different modes' dispersion curves.The minimum shear wave velocity between top and bottom wall rock controls upper limit of dispersion curves;leat bodies make dispersion curves diffuse.The fault has a low impact on channel-waves dispersion.%为了研究不同地质条件下煤层Love型槽波的频散特征,设计了4种典型二维地震地质模型,即围岩不变而煤厚变化(3,5,10,15和20 m)模型,围岩变化(高速围岩与低速围岩)而煤厚不变(10 m)模型,煤层含有断层(煤厚10 m、断层落差5 m)模型和10 m煤层中夹有5 m×5 m、5 m×10 m、5 m×20 m、5 m×50 m砂体模型等;采用SH波波动方程,对上述模型进行了数值模拟,分析了Love型槽波的波场特征,并对正演记录进行了傅里叶变换,计算得到槽波频散图。结果表明:煤厚变化主要影响Love型槽波各阶模式频散曲线的能量分布,上下围岩中最小横波速度控制频散曲线的上限,砂体使频散曲线发散,断层对槽波频散影响较小。

  4. Public involvement in breast cancer research: an analysis and model for future research.

    Science.gov (United States)

    McCormick, Sabrina; Brody, Julia; Brown, Phil; Polk, Ruth

    2004-01-01

    Public involvement in health program planning has been taking place for many years, and has provided a precedent for the emergence of public involvement in research conducted since the early 1990s. Such involvement is now widely seen in breast cancer research, due to the large public concern and major social movement activity. This article reviews current practices and general models of public involvement in research and constructs a prototype. The authors interviewed researchers, program officers, and laypeople in order to understand the obstacles, processes, and benefits. They conclude that public involvement has major ramifications for the democratization of science and the construction of knowledge by teaching lay people about science and sensitizing researchers to concerns of the public. There is growing support on the part of scientists and government agents for public involvement.

  5. Autonomous motivation: involvement in physical activity, and perceived sport competence: structural and mediator models.

    Science.gov (United States)

    Bagøien, Tor Egil; Halvari, Hallgeir

    2005-02-01

    Students in upper secondary school (N = 231, M = 16.6 yr., SD = 1.6) were tested on involvement in physical activity, perceived sport competence, using the Perceived Competence Scale of Harter, and motivational regulation on the Self-regulation Questionnaire of Ryan and Connell. Correlations were positive among involvement in physical activity, autonomous motivation, and perceived sport competence. A hypothetical model indicated that autonomous motivation mediates the relation between perceived sport competence and involvement in physical activity. Although LISREL analysis supported this mediation, the best model fit of the data supported a structural model with involvement in physical activity (R2 = .63) to mediate between autonomous motivation and perceived competence (R2 = .47). Results are interpreted and discussed in terms of self-determination theory.

  6. Students' Involvement in Authentic Modelling Practices as Contexts in Chemistry Education

    Science.gov (United States)

    Prins, Gjalt T.; Bulte, Astrid M. W.; van Driel, Jan H.; Pilot, Albert

    2009-11-01

    In science education students should come to understand the nature and significance of models. A promising strategy to achieve this goal is using authentic modelling practices as contexts for meaningful learning of models and modelling. An authentic practice is defined as professionals working with common motives and purposes, pertaining to a similar type of procedure and applying relevant knowledge on the modelling issue they work on. In this study we evaluate whether the use of authentic practices initiates adequate students’ involvement. This was done by investigating students’ interests, ownership, familiarity and complexity. In addition, we evaluated students’ expressed modelling procedures in response to the modelling issues. We designed learning tasks which were enacted by a focus group of students. Three primary data sources were used to collect data. Firstly, a group discussion was organised in which students’ reflected on both authentic practices. Secondly, students filled in written questionnaires containing items on affective and cognitive aspects. Thirdly, the realised modelling procedures by students were analysed. The results show that students’ involvement was successfully initiated, evidenced by motivated students, willingness to continue and the completeness and quality of the realised modelling procedures. The design of the learning tasks proved to be successful in realising this involvement. The results obtained in this study support the strategy of using authentic modelling practices as contexts for meaningful learning of models and modelling.

  7. Global Processing Speed in Children with Low Reading Ability and in Children and Adults with Typical Reading Ability: Exploratory Factor Analytic Models

    Science.gov (United States)

    Peter, Beate; Matsushita, Mark; Raskind, Wendy H.

    2011-01-01

    Purpose: To investigate processing speed as a latent dimension in children with dyslexia and children and adults with typical reading skills. Method: Exploratory factor analysis (FA) was based on a sample of multigenerational families, each ascertained through a child with dyslexia. Eleven measures--6 of them timed--represented verbal and…

  8. Adolescents and Music Media: Toward an Involvement-Mediational Model of Consumption and Self-Concept

    Science.gov (United States)

    Kistler, Michelle; Rodgers, Kathleen Boyce; Power, Thomas; Austin, Erica Weintraub; Hill, Laura Griner

    2010-01-01

    Using social cognitive theory and structural regression modeling, we examined pathways between early adolescents' music media consumption, involvement with music media, and 3 domains of self-concept (physical appearance, romantic appeal, and global self-worth; N=124). A mediational model was supported for 2 domains of self-concept. Music media…

  9. Does Business Model Affect CSR Involvement? A Survey of Polish Manufacturing and Service Companies

    Directory of Open Access Journals (Sweden)

    Marzanna Katarzyna Witek-Hajduk

    2016-02-01

    Full Text Available The study explores links between types of business models used by companies and their involvement in CSR. As the main part of our conceptual framework we used a business model taxonomy developed by Dudzik and Witek-Hajduk, which identifies five types of models: traditionalists, market players, contractors, distributors, and integrators. From shared characteristics of the business model profiles, we proposed that market players and integrators will show significantly higher levels of involvement in CSR than the three other classes of companies. Among other things, both market players and integrators relied strongly on building own brand value and fostering harmonious supply channel relations, which served as a rationale for our hypothesis. The data for the study were obtained through a combined CATI and CAWI survey on a group of 385 managers of medium and large enterprises. The sample was representative for the three Polish industries of chemical manufacturing, food production, and retailing. Statistical methods included confirmatory factor analysis and one-way ANOVA with contrasts and post hoc tests. The findings supported our hypothesis, showing that market players and integrators were indeed more engaged in CSR than other groups of firms. This may suggest that managers in control of these companies could bolster the integrity of their business models by increasing CSR involvement. Another important contribution of the study was to propose and validate a versatile scale for assessing CSR involvement, which showed measurement invariance for all involved industries.

  10. Customer involvement in greening the supply chain: an interpretive structural modeling methodology

    Science.gov (United States)

    Kumar, Sanjay; Luthra, Sunil; Haleem, Abid

    2013-04-01

    The role of customers in green supply chain management needs to be identified and recognized as an important research area. This paper is an attempt to explore the involvement aspect of customers towards greening of the supply chain (SC). An empirical research approach has been used to collect primary data to rank different variables for effective customer involvement in green concept implementation in SC. An interpretive structural-based model has been presented, and variables have been classified using matrice d' impacts croises- multiplication appliqué a un classement analysis. Contextual relationships among variables have been established using experts' opinions. The research may help practicing managers to understand the interaction among variables affecting customer involvement. Further, this understanding may be helpful in framing the policies and strategies to green SC. Analyzing interaction among variables for effective customer involvement in greening SC to develop the structural model in the Indian perspective is an effort towards promoting environment consciousness.

  11. A model for the occurrence and analysis of ionic thermocurrent spectrum involving different orders of kinetics

    Indian Academy of Sciences (India)

    Jai Prakash

    2013-01-01

    Ionic thermocurrent (ITC) spectrum is much similar to a thermoluminescence (TL) glow curve involving monomolecular kinetics. It has already been reported that different orders of kinetics are involved in TL processes, which depend specifically on the extent of recombination and simultaneous retrapping. It is found that the involvement of different orders of kinetics in ITC spectrum depends on the experimental conditions of polarization and rate of rapid cooling. Consequently, order of kinetics involved in the ITC spectrum does not represent any specific feature of the system under investigation. An equation is developed which explains the occurrence of ITC spectrum involving any order of kinetics. Dielectric relaxation parameters, order of kinetics and approximate number of dipoles per unit volume are evaluated conveniently and easily following the proposed model.

  12. Expanding the Work Phases Model: User and Expert Involvement in the Construction of Online Specialised Dictionaries

    DEFF Research Database (Denmark)

    Leroyer, Patrick

    The purpose of this article is to establish new proposals for the lexicographic process and the involvement of experts and users in the construction of online specialised dictionaries. It is argued that the ENeL action should also have a view to the development of innovative theories...... and methodologies for the construction of online specialised dictionaries, and a new model for user and expert involvement is proposed....

  13. Childhood craniopharyngioma: greater hypothalamic involvement before surgery is associated with higher homeostasis model insulin resistance index

    Directory of Open Access Journals (Sweden)

    Sainte-Rose Christian

    2009-04-01

    Full Text Available Abstract Background Obesity seems to be linked to the hypothalamic involvement in craniopharyngioma. We evaluated the pre-surgery relationship between the degree of this involvement on magnetic resonance imaging and insulin resistance, as evaluated by the homeostasis model insulin resistance index (HOMA. As insulin-like growth factor 1, leptin, soluble leptin receptor (sOB-R and ghrelin may also be involved, we compared their plasma concentrations and their link to weight change. Methods 27 children with craniopharyngioma were classified as either grade 0 (n = 7, no hypothalamic involvement, grade 1 (n = 8, compression without involvement, or grade 2 (n = 12, severe involvement. Results Despite having similar body mass indexes (BMI, the grade 2 patients had higher glucose, insulin and HOMA before surgery than the grade 0 (P = 0.02, The data for the whole population before and 6–18 months after surgery showed increases in BMI (P Conclusion The hypothalamic involvement by the craniopharyngioma before surgery seems to determine the degree of insulin resistance, regardless of the BMI. The pre-surgery HOMA values were correlated with the post-surgery weight gain. This suggests that obesity should be prevented by reducing inn secretion in those cases with hypothalamic involvement.

  14. Hybrid transfinite element modeling/analysis of nonlinear heat conduction problems involving phase change

    Science.gov (United States)

    Tamma, Kumar K.; Railkar, Sudhir B.

    1988-01-01

    The present paper describes the applicability of hybrid transfinite element modeling/analysis formulations for nonlinear heat conduction problems involving phase change. The methodology is based on application of transform approaches and classical Galerkin schemes with finite element formulations to maintain the modeling versatility and numerical features for computational analysis. In addition, in conjunction with the above, the effects due to latent heat are modeled using enthalpy formulations to enable a physically realistic approximation to be dealt computationally for materials exhibiting phase change within a narrow band of temperatures. Pertinent details of the approach and computational scheme adapted are described in technical detail. Numerical test cases of comparative nature are presented to demonstrate the applicability of the proposed formulations for numerical modeling/analysis of nonlinear heat conduction problems involving phase change.

  15. Petri Net Modeling of the Brain Circuit Involved in Aggressive Behavior

    OpenAIRE

    Moreno, Carlos B.; Díaz, José-Luis; Martínez, J. H.

    2015-01-01

    The purpose of this work in to demonstrate the initial results of a research project having as its goal to develop dynamic models of the brain network involved in aggressive behavior. In this way, the complex neural process correlated to basic anger emotions and resulting in aggressive behaviors is purportedly schematized by the use of Petri nets, a work-flow computational tool. Initially, the modeling technique is introduced taking into account the most recent and accepted notion of the neur...

  16. Herpes zoster - typical and atypical presentations.

    Science.gov (United States)

    Dayan, Roy Rafael; Peleg, Roni

    2017-08-01

    Varicella- zoster virus infection is an intriguing medical entity that involves many medical specialties including infectious diseases, immunology, dermatology, and neurology. It can affect patients from early childhood to old age. Its treatment requires expertise in pain management and psychological support. While varicella is caused by acute viremia, herpes zoster occurs after the dormant viral infection, involving the cranial nerve or sensory root ganglia, is re-activated and spreads orthodromically from the ganglion, via the sensory nerve root, to the innervated target tissue (skin, cornea, auditory canal, etc.). Typically, a single dermatome is involved, although two or three adjacent dermatomes may be affected. The lesions usually do not cross the midline. Herpes zoster can also present with unique or atypical clinical manifestations, such as glioma, zoster sine herpete and bilateral herpes zoster, which can be a challenging diagnosis even for experienced physicians. We discuss the epidemiology, pathophysiology, diagnosis and management of Herpes Zoster, typical and atypical presentations.

  17. Predicting Preschoolers' Attachment Security from Fathers' Involvement, Internal Working Models, and Use of Social Support

    Science.gov (United States)

    Newland, Lisa A.; Coyl, Diana D.; Freeman, Harry

    2008-01-01

    Associations between preschoolers' attachment security, fathers' involvement (i.e. parenting behaviors and consistency) and fathering context (i.e. fathers' internal working models (IWMs) and use of social support) were examined in a subsample of 102 fathers, taken from a larger sample of 235 culturally diverse US families. The authors predicted…

  18. Helpful Components Involved in the Cognitive-Experiential Model of Dream Work

    Science.gov (United States)

    Tien, Hsiu-Lan Shelley; Chen, Shuh-Chi; Lin, Chia-Huei

    2009-01-01

    The purpose of the study was to examine the helpful components involved in the Hill's cognitive-experiential dream work model. Participants were 27 volunteer clients from colleges and universities in northern and central parts of Taiwan. Each of the clients received 1-2 sessions of dream interpretations. The cognitive-experiential dream work model…

  19. A Research Framework for Understanding the Practical Impact of Family Involvement in the Juvenile Justice System: The Juvenile Justice Family Involvement Model.

    Science.gov (United States)

    Walker, Sarah Cusworth; Bishop, Asia S; Pullmann, Michael D; Bauer, Grace

    2015-12-01

    Family involvement is recognized as a critical element of service planning for children's mental health, welfare and education. For the juvenile justice system, however, parents' roles in this system are complex due to youths' legal rights, public safety, a process which can legally position parents as plaintiffs, and a historical legacy of blaming parents for youth indiscretions. Three recent national surveys of juvenile justice-involved parents reveal that the current paradigm elicits feelings of stress, shame and distrust among parents and is likely leading to worse outcomes for youth, families and communities. While research on the impact of family involvement in the justice system is starting to emerge, the field currently has no organizing framework to guide a research agenda, interpret outcomes or translate findings for practitioners. We propose a research framework for family involvement that is informed by a comprehensive review and content analysis of current, published arguments for family involvement in juvenile justice along with a synthesis of family involvement efforts in other child-serving systems. In this model, family involvement is presented as an ascending, ordinal concept beginning with (1) exclusion, and moving toward climates characterized by (2) information-giving, (3) information-eliciting and (4) full, decision-making partnerships. Specific examples of how courts and facilities might align with these levels are described. Further, the model makes predictions for how involvement will impact outcomes at multiple levels with applications for other child-serving systems.

  20. A devolved model for public involvement in the field of mental health research: case study learning.

    Science.gov (United States)

    Moule, Pam; Davies, Rosie

    2016-12-01

    Patient and public involvement in all aspects of research is espoused and there is a continued interest in understanding its wider impact. Existing investigations have identified both beneficial outcomes and remaining issues. This paper presents the impact of public involvement in one case study led by a mental health charity conducted as part of a larger research project. The case study used a devolved model of working, contracting with service user-led organizations to maximize the benefits of local knowledge on the implementation of personalized budgets, support recruitment and local user-led organizations. To understand the processes and impact of public involvement in a devolved model of working with user-led organizations. Multiple data collection methods were employed throughout 2012. These included interviews with the researchers (n = 10) and research partners (n = 5), observation of two case study meetings and the review of key case study documentation. Analysis was conducted in NVivo10 using a coding framework developed following a literature review. Five key themes emerged from the data; Devolved model, Nature of involvement, Enabling factors, Implementation challenges and Impact. While there were some challenges of implementing the devolved model it is clear that our findings add to the growing understanding of the positive benefits research partners can bring to complex research. A devolved model can support the involvement of user-led organizations in research if there is a clear understanding of the underpinning philosophy and support mechanisms are in place. © 2015 The Authors. Health Expectations Published by John Wiley & Sons Ltd.

  1. Selection Model of Optional Parts in Suppliers Involved in New Product Development

    Institute of Scientific and Technical Information of China (English)

    MU Lifeng; TANG Jiafu; PAN Zhendong; HAN Yi

    2006-01-01

    Quality function deployment (QFD), which can translate efficiently customer requirement (CRs) into technical attributes (TAs), is widely used in new product development (NPD) as an efficient customer-driven approach. After lots of QFD application is applied in manufacturing fields, it was proved that without considering suppliers involved, it is difficult to get precise and satisfying results in each process of QFD, particularly part deployment. The paper will address the issues of a model of optional parts selection in suppliers involved in part deployment process. Further, it has been applied to an ERP system reconstruction and updating problem as an illustration.

  2. Opioid receptor types involved in the development of nicotine physical dependence in an invertebrate (Planaria) model.

    Science.gov (United States)

    Raffa, Robert B; Baron, Steve; Bhandal, Jaspreet S; Brown, Tevin; Song, Kevin; Tallarida, Christopher S; Rawls, Scott M

    2013-11-01

    Recent data suggest that opioid receptors are involved in the development of nicotine physical dependence in mammals. Evidence in support of a similar involvement in an invertebrate (Planaria) is presented using the selective opioid receptor antagonist naloxone, and the more receptor subtype-selective antagonists CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) (μ, MOR), naltrindole (δ, DOR), and nor-BNI (norbinaltorphimine) (κ, KOR). Induction of physical dependence was achieved by 60-min pre-exposure of planarians to nicotine and was quantified by abstinence-induced withdrawal (reduction in spontaneous locomotor activity). Known MOR and DOR subtype-selective opioid receptor antagonists attenuated the withdrawal, as did the non-selective antagonist naloxone, but a KOR subtype-selective antagonist did not. An involvement of MOR and DOR, but not KOR, in the development of nicotine physical dependence or in abstinence-induced withdrawal was thus demonstrated in a sensitive and facile invertebrate model.

  3. A homology model of Xyloglucan Xylosyltransferase 2 reveals critical amino acids involved in substrate binding.

    Science.gov (United States)

    Culbertson, Alan T; Tietze, Alesia A; Tietze, Daniel; Chou, Yi-Hsiang; Smith, Adrienne L; Young, Zachary T; Zabotina, Olga A

    2016-09-01

    In dicotyledonous plants, xyloglucan (XyG) is the most abundant hemicellulose of the primary cell wall. The enzymes involved in XyG biosynthesis have been identified through reverse-genetics and activity was characterized by heterologous expression. Currently, there is no information on the atomic structures or amino acids involved in activity or substrate binding of any of the Golgi-localized XyG biosynthetic enzymes. A homology model of the xyloglucan xylosyltransferase 2 (XXT2) catalytic domain was built on the basis of the crystal structure of A64Rp. Molecular dynamics simulations revealed that the homology model retains the glycosyltransferase (GT)-A fold of the template structure used to build the homology model indicating that XXT2 likely has a GT-A fold. According to the XXT2 homology model, six amino acids (Phe204, Lys207, Asp228, Ser229, Asp230, His378) were selected and their contribution in catalytic activity was investigated. Site-directed mutagenesis studies show that Asp228, Asp230 and His378 are critical for XXT2 activity and are predicted to be involved in coordination of manganese ion. Lys207 was also found to be critical for protein activity and the homology model indicates a critical role in substrate binding. Additionally, Phe204 mutants have less of an impact on XXT2 activity with the largest effect when replaced with a polar residue. This is the first study that investigates the amino acids involved in substrate binding of the XyG-synthesizing xylosyltransferases and contributes to the understanding of the mechanisms of polysaccharide-synthesizing GTs and XyG biosynthesis. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  4. Evaluation of vehicle damage involved in road crashes based on quantificated model

    Institute of Scientific and Technical Information of China (English)

    FAN Yan-hui; XU Hong-guo; JIANG Hua-ping

    2008-01-01

    Based on economics theory, social value loss caused by vehicle involved in crashes as well as various factors influencing on it were analyzed, the corresponding micro-econometrics model was theoretically given. Moreover, the practicability of the model,the veracity and rationality of quantification were analyzed. Based on probability theory and mathematical statistical theory, macro approach to evaluating vehicle damage in crashes was presented, and the corresponding macro-econometrics model was constructed. In addition, the macro-econometrics model was utilized to assess economic loss from statistical data of vehicle damaged in crashes, which has shown that the model can meet the demand of quantification analysis of vehicle damage, and be applied to the evaluation of economic loss caused by crashes. The results in this paper will be of practical significance for scientific, comprehensive and rational evaluating socio-economic loss caused by road crashes.

  5. Degree of multicollinearity and variables involved in linear dependence in additive-dominant models

    Directory of Open Access Journals (Sweden)

    Juliana Petrini

    2012-12-01

    Full Text Available The objective of this work was to assess the degree of multicollinearity and to identify the variables involved in linear dependence relations in additive-dominant models. Data of birth weight (n=141,567, yearling weight (n=58,124, and scrotal circumference (n=20,371 of Montana Tropical composite cattle were used. Diagnosis of multicollinearity was based on the variance inflation factor (VIF and on the evaluation of the condition indexes and eigenvalues from the correlation matrix among explanatory variables. The first model studied (RM included the fixed effect of dam age class at calving and the covariates associated to the direct and maternal additive and non-additive effects. The second model (R included all the effects of the RM model except the maternal additive effects. Multicollinearity was detected in both models for all traits considered, with VIF values of 1.03 - 70.20 for RM and 1.03 - 60.70 for R. Collinearity increased with the increase of variables in the model and the decrease in the number of observations, and it was classified as weak, with condition index values between 10.00 and 26.77. In general, the variables associated with additive and non-additive effects were involved in multicollinearity, partially due to the natural connection between these covariables as fractions of the biological types in breed composition.

  6. Portraiture of constructivist parental involvement: A model to develop a community of practice

    Science.gov (United States)

    Dignam, Christopher Anthony

    This qualitative research study addressed the problem of the lack of parental involvement in secondary school science. Increasing parental involvement is vital in supporting student academic achievement and social growth. The purpose of this emergent phenomenological study was to identify conditions required to successfully construct a supportive learning environment to form partnerships between students, parents, and educators. The overall research question in this study investigated the conditions necessary to successfully enlist parental participation with students during science inquiry investigations at the secondary school level. One hundred thirteen pairs of parents and students engaged in a 6-week scientific inquiry activity and recorded attitudinal data in dialogue journals, questionnaires, open-ended surveys, and during one-one-one interviews conducted by the researcher between individual parents and students. Comparisons and cross-interpretations of inter-rater, codified, triangulated data were utilized for identifying emergent themes. Data analysis revealed the active involvement of parents in researching with their child during inquiry investigations, engaging in journaling, and assessing student performance fostered partnerships among students, parents, and educators and supported students' social skills development. The resulting model, employing constructivist leadership and enlisting parent involvement, provides conditions and strategies required to develop a community of practice that can help effect social change. The active involvement of parents fostered improved efficacy and a holistic mindset to develop in parents, students, and teachers. Based on these findings, the interactive collaboration of parents in science learning activities can proactively facilitate a community of practice that will assist educators in facilitating social change.

  7. The typical behaviour of relays

    OpenAIRE

    Alamino, Roberto C.; Saad, David

    2007-01-01

    The typical behaviour of the relay-without-delay channel and its many-units generalisation, termed the relay array, under LDPC coding, is studied using methods of statistical mechanics. A demodulate-and-forward strategy is analytically solved using the replica symmetric ansatz which is exact in the studied system at the Nishimori's temperature. In particular, the typical level of improvement in communication performance by relaying messages is shown in the case of small and large number of re...

  8. Testing typicality in multiverse cosmology

    Science.gov (United States)

    Azhar, Feraz

    2015-05-01

    In extracting predictions from theories that describe a multiverse, we face the difficulty that we must assess probability distributions over possible observations prescribed not just by an underlying theory, but by a theory together with a conditionalization scheme that allows for (anthropic) selection effects. This means we usually need to compare distributions that are consistent with a broad range of possible observations with actual experimental data. One controversial means of making this comparison is by invoking the "principle of mediocrity": that is, the principle that we are typical of the reference class implicit in the conjunction of the theory and the conditionalization scheme. In this paper, we quantitatively assess the principle of mediocrity in a range of cosmological settings, employing "xerographic distributions" to impose a variety of assumptions regarding typicality. We find that for a fixed theory, the assumption that we are typical gives rise to higher likelihoods for our observations. If, however, one allows both the underlying theory and the assumption of typicality to vary, then the assumption of typicality does not always provide the highest likelihoods. Interpreted from a Bayesian perspective, these results support the claim that when one has the freedom to consider different combinations of theories and xerographic distributions (or different "frameworks"), one should favor the framework that has the highest posterior probability; and then from this framework one can infer, in particular, how typical we are. In this way, the invocation of the principle of mediocrity is more questionable than has been recently claimed.

  9. Involving the elderly in the design process: a participatory design model for usability, safety and attractiveness

    OpenAIRE

    Demirbilek, Oya

    1999-01-01

    Ankara : Institute of Economics and Social Sciences of Bilkent University, 1999. Thesis (Ph.D.) -- Bilkent University, 1999 Includes bibliographical references leaves 113-131 This work presents a conceptual model involving the elderly users into the design process by means of participatory design sessions, where the expertise of designers and the real requirements and opinions of elderly end-users, related to how objects, environments and equipment should be designed to allow ageing ...

  10. Semi-Implicit Algorithm for Elastoplastic Damage Models Involving Energy Integration

    OpenAIRE

    Ji Zhang; Jie Li

    2016-01-01

    This study aims to develop a semi-implicit constitutive integration algorithm for a class of elastoplastic damage models where calculation of damage energy release rates involves integration of free energy. The constitutive equations with energy integration are split into the elastic predictor, plastic corrector, and damage corrector. The plastic corrector is solved with an improved format of the semi-implicit spectral return mapping, which is characterized by constant flow direction and plas...

  11. Development of a Gravid Uterus Model for the Study of Road Accidents Involving Pregnant Women.

    Science.gov (United States)

    Auriault, F; Thollon, L; Behr, M

    2016-01-01

    Car accident simulations involving pregnant women are well documented in the literature and suggest that intra-uterine pressure could be responsible for the phenomenon of placental abruption, underlining the need for a realistic amniotic fluid model, including fluid-structure interactions (FSI). This study reports the development and validation of an amniotic fluid model using an Arbitrary Lagrangian Eulerian formulation in the LS-DYNA environment. Dedicated to the study of the mechanisms responsible for fetal injuries resulting from road accidents, the fluid model was validated using dynamic loading tests. Drop tests were performed on a deformable water-filled container at acceleration levels that would be experienced in a gravid uterus during a frontal car collision at 25 kph. During the test device braking phase, container deformation induced by inertial effects and FSI was recorded by kinematic analysis. These tests were then simulated in the LS-DYNA environment to validate a fluid model under dynamic loading, based on the container deformations. Finally, the coupling between the amniotic fluid model and an existing finite-element full-body pregnant woman model was validated in terms of pressure. To do so, experimental test results performed on four postmortem human surrogates (PMHS) (in which a physical gravid uterus model was inserted) were used. The experimental intra-uterine pressure from these tests was compared to intra uterine pressure from a numerical simulation performed under the same loading conditions. Both free fall numerical and experimental responses appear strongly correlated. The relationship between the amniotic fluid model and pregnant woman model provide intra-uterine pressure values correlated with the experimental test responses. The use of an Arbitrary Lagrangian Eulerian formulation allows the analysis of FSI between the amniotic fluid and the gravid uterus during a road accident involving pregnant women.

  12. Molecular modelling of S-RNases involved in almond self-incompatibility

    Directory of Open Access Journals (Sweden)

    Angel eFernandez i Marti

    2012-06-01

    Full Text Available Gametophytic self-incompatibility (GSI is a mechanism in flowering plants, to prevent inbreeding and promote outcrossing. GSI is under the control of a specific locus, known as the S-locus, which contains at least two genes, the RNase and the SFB. Active S-RNases in the style are essential for rejection of haploid pollen, when the pollen S-allele matches one of two S-alleles of the diploid pistil. However, the nature of their mutual interactions at genetic and biochemical levels remain unclear. Thus, detailed understanding of the protein structure involved in GSI may help in discovering how the proteins involved in GSI may function and how they fulfil their biological roles. To this end, 3D models of the SC (Sf and two SI (S8 and S23 S-RNases of almond were constructed, using comparative modelling tools. The modelled structures consisted of mixed α and β folds, with six helices and six beta-strands. However, the self-compatible (Sf RNase contained an additional extended loop between the conserved domains RC4 and C5, which may be involved in the manifestation of self-compatibility in almond.

  13. Simulation of changes in heavy metal contamination in farmland soils of a typical manufacturing center through logistic-based cellular automata modeling.

    Science.gov (United States)

    Qiu, Menglong; Wang, Qi; Li, Fangbai; Chen, Junjian; Yang, Guoyi; Liu, Liming

    2016-01-01

    A customized logistic-based cellular automata (CA) model was developed to simulate changes in heavy metal contamination (HMC) in farmland soils of Dongguan, a manufacturing center in Southern China, and to discover the relationship between HMC and related explanatory variables (continuous and categorical). The model was calibrated through the simulation and validation of HMC in 2012. Thereafter, the model was implemented for the scenario simulation of development alternatives for HMC in 2022. The HMC in 2002 and 2012 was determined through soil tests and cokriging. Continuous variables were divided into two groups by odds ratios. Positive variables (odds ratios >1) included the Nemerow synthetic pollution index in 2002, linear drainage density, distance from the city center, distance from the railway, slope, and secondary industrial output per unit of land. Negative variables (odds ratios soil pH, and distance from bodies of water. Categorical variables, including soil type, parent material type, organic content grade, and land use type, also significantly influenced HMC according to Wald statistics. The relative operating characteristic and kappa coefficients were 0.91 and 0.64, respectively, which proved the validity and accuracy of the model. The scenario simulation shows that the government should not only implement stricter environmental regulation but also strengthen the remediation of the current polluted area to effectively mitigate HMC.

  14. Seismic wave field simulation of several typical geological models%几种典型地质模型的地震波场数值模拟

    Institute of Scientific and Technical Information of China (English)

    徐佼; 张智; 董超; 陈立波; ; 李飞

    2014-01-01

    Stability condition and astringency of difference equation,the elimination of dispersion are important in seismic wave numerical modeling.From the factors in modeling result,based on two-dimensional acoustic wave equation,the seismic wave numerical modeling is shown by finite difference method with two-order ab-sorbing boundary condition in the wave-field of heterogeneous media and inhomogeneous media.By theory cal-culation and finite difference wave equation numerical modeling in the heterogeneous model,the strata model, the fault model and the anticline model,this method can achieve ideal results if the parameters are reasonable. Through the finite difference method,the wave equation is derived by Taylor series,which makes inherent errors in scattering the wave equation.The low-order difference method may increase the numerical dispersion,and vice versa,the high-order difference method leads to small errors and exact solutions.Meanwhile,larger spatial sampling interval and sampling time interval are better in the calculation rate,but may decrease the correspond-ing numerical dispersion.So consideration must be given to both the accuracy and speed in the finite difference wave equation numerical modeling.%在地震波场数值模拟中,边界条件的选取、差分方程的稳定性条件和收敛性以及频散的消除对于模拟质量至关重要。在综合考虑这些影响因素的基础上,对二维声波方程采用有限差分方法,利用二阶吸收边界条件,模拟了均匀模型、层状模型、断层模型、背斜模型等几种典型介质模型的地震波场。模拟结果揭示了参数的选取对模拟精度的影响程度。通过泰勒级数展开推导得到有限差分波动方程,造成离散的波动方程固有误差的存在。差分阶数越低,频散越严重;相反,有限差分的误差就越小,就越接近于精确解;此外,空间和时间采样间隔越大,会加快计算速度,同时可能会产

  15. Disseminated typical bronchial carcinoid tumor

    Directory of Open Access Journals (Sweden)

    Novković Dobrivoje

    2013-01-01

    Full Text Available Introduction. Bronchial carcinoids belong to a rare type of lung tumors. If they do not expose outstanding neuroendocrine activity, they develop without clearly visible symptoms. They are often detected during a routine examination. According to their clinical pathological features, they are divided into typical and atypical tumors. Typical bronchial carcinoids metastasize to distant organs very rarely. Localized forms are effectively treated by surgery. The methods of conservative treatment should be applied in other cases. Case report. We presented a 65-year-old patient with carcinoid lung tumor detected by a routine examination. Additional analysis (chest X-ray, computed tomography of the chest, ultrasound of the abdomen, skeletal scintigraphy, bronhoscopy, histopathological analysis of the bioptate of bronchial tumor, as well as bronchial brushing cytology and immunohistochemical staining performed with markers specific for neuroendocrine tumor proved a morphologically typical lung carcinoid with dissemination to the liver and skeletal system, which is very rarely found in typical carcinoids. Conclusion. The presented case with carcinoid used to be showed morphological and pathohistological characteristics of typical bronchial carcinoid. With its metastasis to the liver and skeletal system it demonstrated unusual clinical course that used to be considered as rare phenomenon. Due to its frequent asymptomatic course and varied manifestation, bronchial carcinoid could be considered as a diagnostic challenge requiring a multidisciplinary approach.

  16. Exploring Modeling Options and Conversion of Average Response to Appropriate Vibration Envelopes for a Typical Cylindrical Vehicle Panel with Rib-stiffened Design

    Science.gov (United States)

    Harrison, Phil; LaVerde, Bruce; Teague, David

    2009-01-01

    Although applications for Statistical Energy Analysis (SEA) techniques are more widely used in the aerospace industry today, opportunities to anchor the response predictions using measured data from a flight-like launch vehicle structure are still quite valuable. Response and excitation data from a ground acoustic test at the Marshall Space Flight Center permitted the authors to compare and evaluate several modeling techniques available in the SEA module of the commercial code VA One. This paper provides an example of vibration response estimates developed using different modeling approaches to both approximate and bound the response of a flight-like vehicle panel. Since both vibration response and acoustic levels near the panel were available from the ground test, the evaluation provided an opportunity to learn how well the different modeling options can match band-averaged spectra developed from the test data. Additional work was performed to understand the spatial averaging of the measurements across the panel from measured data. Finally an evaluation/comparison of two conversion approaches from the statistical average response results that are output from an SEA analysis to a more useful envelope of response spectra appropriate to specify design and test vibration levels for a new vehicle.

  17. Evaluation of the CENTURY model using long-term fertilization trials under corn-wheat cropping systems in the typical croplands of China.

    Science.gov (United States)

    Cong, Rihuan; Wang, Xiujun; Xu, Minggang; Ogle, Stephen M; Parton, William J

    2014-01-01

    Soil organic matter models are widely used to study soil organic carbon (SOC) dynamics. Here, we used the CENTURY model to simulate SOC in wheat-corn cropping systems at three long-term fertilization trials. Our study indicates that CENTURY can simulate fertilization effects on SOC dynamics under different climate and soil conditions. The normalized root mean square error is less than 15% for all the treatments. Soil carbon presents various changes under different fertilization management. Treatment with straw return would enhance SOC to a relatively stable level whereas chemical fertilization affects SOC differently across the three sites. After running CENTURY over the period of 1990-2050, the SOC levels are predicted to increase from 31.8 to 52.1 Mg ha-1 across the three sites. We estimate that the carbon sequestration potential between 1990 and 2050 would be 9.4-35.7 Mg ha-1 under the current high manure application at the three sites. Analysis of SOC in each carbon pool indicates that long-term fertilization enhances the slow pool proportion but decreases the passive pool proportion. Model results suggest that change in the slow carbon pool is the major driver of the overall trends in SOC stocks under long-term fertilization.

  18. Testing typicality in multiverse cosmology

    CERN Document Server

    Azhar, Feraz

    2015-01-01

    In extracting predictions from theories that describe a multiverse, we face the difficulty that we must assess probability distributions over possible observations, prescribed not just by an underlying theory, but by a theory together with a conditionalization scheme that allows for (anthropic) selection effects. This means we usually need to compare distributions that are consistent with a broad range of possible observations, with actual experimental data. One controversial means of making this comparison is by invoking the 'principle of mediocrity': that is, the principle that we are typical of the reference class implicit in the conjunction of the theory and the conditionalization scheme. In this paper, I quantitatively assess the principle of mediocrity in a range of cosmological settings, employing 'xerographic distributions' to impose a variety of assumptions regarding typicality. I find that for a fixed theory, the assumption that we are typical gives rise to higher likelihoods for our observations. I...

  19. System Model Bias Processing Approach for Regional Coordinated States Information Involved Filtering

    Directory of Open Access Journals (Sweden)

    Zebo Zhou

    2016-01-01

    Full Text Available In the Kalman filtering applications, the conventional dynamic model which connects the states information of two consecutive epochs by state transition matrix is usually predefined and assumed to be invariant. Aiming to improve the adaptability and accuracy of dynamic model, we propose multiple historical states involved filtering algorithm. An autoregressive model is used as the dynamic model which is subsequently combined with observation model for deriving the optimal window-recursive filter formulae in the sense of minimum mean square error principle. The corresponding test statistics characteristics of system residuals are discussed in details. The test statistics of regional predicted residuals are then constructed in a time-window for model bias testing with two hypotheses, that is, the null and alternative hypotheses. Based on the innovations test statistics, we develop a model bias processing procedure including bias detection, location identification, and state correction. Finally, the minimum detectable bias and bias-to-noise ratio are both computed for evaluating the internal and external reliability of overall system, respectively.

  20. VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease.

    Directory of Open Access Journals (Sweden)

    Mallikarjun Badadani

    Full Text Available Dominant mutations in the valosin containing protein (VCP gene cause inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD. We have generated a knock-in mouse model with the common R155H mutation. Mice demonstrate progressive muscle weakness starting approximately at the age of 6 months. Histology of mutant muscle showed progressive vacuolization of myofibrils and centrally located nuclei, and immunostaining shows progressive cytoplasmic accumulation of TDP-43 and ubiquitin-positive inclusion bodies in quadriceps myofibrils and brain. Increased LC3-II staining of muscle sections representing increased number of autophagosomes suggested impaired autophagy. Increased apoptosis was demonstrated by elevated caspase-3 activity and increased TUNEL-positive nuclei. X-ray microtomography (uCT images show radiolucency of distal femurs and proximal tibiae in knock-in mice and uCT morphometrics shows decreased trabecular pattern and increased cortical wall thickness. Bone histology and bone marrow derived macrophage cultures in these mice revealed increased osteoclastogenesis observed by TRAP staining suggestive of Paget bone disease. The VCP(R155H/+ knock-in mice replicate the muscle, bone and brain pathology of inclusion body myopathy, thus representing a useful model for preclinical studies.

  1. Pore scale modeling of reactive transport involved in geologic CO2 sequestration

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Qinjin [Los Alamos National Laboratory; Lichtner, Peter C [Los Alamos National Laboratory; Viswanathan, Hari S [Los Alamos National Laboratory; Abdel-fattah, Amr I [Los Alamos National Laboratory

    2009-01-01

    We apply a multi-component reactive transport lattice Boltzmann model developed in previolls studies to modeling the injection of a C02 saturated brine into various porous media structures at temperature T=25 and 80 C. The porous media are originally consisted of calcite. A chemical system consisting of Na+, Ca2+, Mg2+, H+, CO2(aq), and CI-is considered. The fluid flow, advection and diHusion of aqueous species, homogeneous reactions occurring in the bulk fluid, as weB as the dissolution of calcite and precipitation of dolomite are simulated at the pore scale. The effects of porous media structure on reactive transport are investigated. The results are compared with continuum scale modeling and the agreement and discrepancy are discussed. This work may shed some light on the fundamental physics occurring at the pore scale for reactive transport involved in geologic C02 sequestration.

  2. Model correction factor method for reliability problems involving integrals of non-Gaussian random fields

    DEFF Research Database (Denmark)

    Franchin, P.; Ditlevsen, Ove Dalager; Kiureghian, Armen Der

    2002-01-01

    The model correction factor method (MCFM) is used in conjunction with the first-order reliability method (FORM) to solve structural reliability problems involving integrals of non-Gaussian random fields. The approach replaces the limit-state function with an idealized one, in which the integrals...... are considered to be Gaussian. Conventional FORM analysis yields the linearization point of the idealized limit-state surface. A model correction factor is then introduced to push the idealized limit-state surface onto the actual limit-state surface. A few iterations yield a good approximation of the reliability...... reliability method; Model correction factor method; Nataf field integration; Non-Gaussion random field; Random field integration; Structural reliability; Pile foundation reliability...

  3. Modelling binaural processes involved in simultaneous reflection masking: limitations of current models

    DEFF Research Database (Denmark)

    Buchholz, Jörg

    2007-01-01

    Masked thresholds were measured for a single test reflection, masked by the direct sound, as a function of the reflection delay. This was done for diotic as well as for dichotic stimulus presentations and all stimuli were presented via headphones. The input signal was a 200-ms long broadband noise....... The dichotic threshold decreased with increasing reflection delay indicating an increase in binaural detection performance with increasing reflection delay. Comparing the dichotic threshold to the corresponding diotic threshold, for delays below 7-10 ms, the dichotic threshold was found to be higher than...... the diotic threshold while it was lower than the diotic threshold for larger delays. Hence, the binaural system seems to deteriorate auditory detection performance for very early reflections and to enhance auditory detection performance for later reflections. Existing binaural (detection) models...

  4. Modelling of phase equilibria and related properties of mixtures involving lipids

    DEFF Research Database (Denmark)

    Cunico, Larissa

    Many challenges involving physical and thermodynamic properties in the production of edible oils and biodiesel are observed, such as availability of experimental data and realiable prediction. In the case of lipids, a lack of experimental data for pure components and also for their mixtures in open...... literature was observed, what makes it necessary to development reliable predictive models from limited data. One of the first steps of this project was the creation of a database containing properties of mixtures involved in tasks related to process design, simulation, and optimization as well as design...... of chemicals based products. This database was combined with the existing lipids database of pure component properties. To contribute to the missing data, measurements of isobaric vapour-liquid equilibrium (VLE) data of two binary mixtures at two different pressures were performed using Differential Scanning...

  5. A comparative modeling and molecular docking study on Mycobacterium tuberculosis targets involved in peptidoglycan biosynthesis.

    Science.gov (United States)

    Fakhar, Zeynab; Naiker, Suhashni; Alves, Claudio N; Govender, Thavendran; Maguire, Glenn E M; Lameira, Jeronimo; Lamichhane, Gyanu; Kruger, Hendrik G; Honarparvar, Bahareh

    2016-11-01

    An alarming rise of multidrug-resistant Mycobacterium tuberculosis strains and the continuous high global morbidity of tuberculosis have reinvigorated the need to identify novel targets to combat the disease. The enzymes that catalyze the biosynthesis of peptidoglycan in M. tuberculosis are essential and noteworthy therapeutic targets. In this study, the biochemical function and homology modeling of MurI, MurG, MraY, DapE, DapA, Alr, and Ddl enzymes of the CDC1551 M. tuberculosis strain involved in the biosynthesis of peptidoglycan cell wall are reported. Generation of the 3D structures was achieved with Modeller 9.13. To assess the structural quality of the obtained homology modeled targets, the models were validated using PROCHECK, PDBsum, QMEAN, and ERRAT scores. Molecular dynamics simulations were performed to calculate root mean square deviation (RMSD) and radius of gyration (Rg) of MurI and MurG target proteins and their corresponding templates. For further model validation, RMSD and Rg for selected targets/templates were investigated to compare the close proximity of their dynamic behavior in terms of protein stability and average distances. To identify the potential binding mode required for molecular docking, binding site information of all modeled targets was obtained using two prediction algorithms. A docking study was performed for MurI to determine the potential mode of interaction between the inhibitor and the active site residues. This study presents the first accounts of the 3D structural information for the selected M. tuberculosis targets involved in peptidoglycan biosynthesis.

  6. Investigation of pulmonary involvement in inflammatory bowel disease in an experimental model of colitis.

    Science.gov (United States)

    Aydin, Bunyamin; Songur, Yıldıran; Songur, Necla; Aksu, Oğuzhan; Senol, Altug; Ciris, I Metin; Sutcu, Recep

    2016-09-01

    Inflammatory bowel disease (IBD) may also involve various extra-intestinal organs. Clinical studies have found asymptomatic/symptomatic pulmonary involvement in 1% to 6% of patients with IBD. The present study histopathologically investigated pulmonary involvement in an experimental model of colitis in order to demonstrate pulmonary tissue involvement in IBD and to expose potential etiological factors. It also explored the relation between inflammation and tissue concentrations of vascular endothelial growth factor (VEGF) and tumor necrosis factor α (TNF-α). The study comprised 24 male Wistar albino rats. The rats were divided into four groups of six rats each. Acute colitis was induced in two separate groups using either the dextran sulphate sodium (DSS) or trinitrobenzene sulfonic acid (TNBS) method, while the other two groups were used as controls for each model of colitis. Wallace scoring was used for macroscopic assessment of colitis, and the lungs were histopathologically examined. Concentrations of VEGF and TNF-α in pulmonary tissue were measured by the enzyme-linked immunosorbent assay method. The number of animals that had alveolar hemorrhage was significantly higher in the TNBS-induced colitis and DSS-induced colitis groups compared to their own control groups (p = 0.015 and p = 0.015, respectively). VEGF and TNF-α concentrations in pulmonary tissues were significantly increased in both the TNBS colitis and DSS colitis groups compared to their own control groups (p = 0.002 and p = 0.004, respectively; and p = 0.002 and p = 0.002, respectively). The present study demonstrated that significant and serious histopathological changes directly associated with colitis occur in the lungs in IBD.

  7. Investigation of pulmonary involvement in inflammatory bowel disease in an experimental model of colitis

    Science.gov (United States)

    Aydin, Bunyamin; Songur, Yıldıran; Songur, Necla; Aksu, Oğuzhan; Senol, Altug; Ciris, I. Metin; Sutcu, Recep

    2016-01-01

    Background/Aims: Inflammatory bowel disease (IBD) may also involve various extra-intestinal organs. Clinical studies have found asymptomatic/symptomatic pulmonary involvement in 1% to 6% of patients with IBD. The present study histopathologically investigated pulmonary involvement in an experimental model of colitis in order to demonstrate pulmonary tissue involvement in IBD and to expose potential etiological factors. It also explored the relation between inflammation and tissue concentrations of vascular endothelial growth factor (VEGF) and tumor necrosis factor α (TNF-α). Methods: The study comprised 24 male Wistar albino rats. The rats were divided into four groups of six rats each. Acute colitis was induced in two separate groups using either the dextran sulphate sodium (DSS) or trinitrobenzene sulfonic acid (TNBS) method, while the other two groups were used as controls for each model of colitis. Wallace scoring was used for macroscopic assessment of colitis, and the lungs were histopathologically examined. Concentrations of VEGF and TNF-α in pulmonary tissue were measured by the enzyme-linked immunosorbent assay method. Results: The number of animals that had alveolar hemorrhage was significantly higher in the TNBS-induced colitis and DSS-induced colitis groups compared to their own control groups (p = 0.015 and p = 0.015, respectively). VEGF and TNF-α concentrations in pulmonary tissues were significantly increased in both the TNBS colitis and DSS colitis groups compared to their own control groups (p = 0.002 and p = 0.004, respectively; and p = 0.002 and p = 0.002, respectively). Conclusions: The present study demonstrated that significant and serious histopathological changes directly associated with colitis occur in the lungs in IBD. PMID:27539446

  8. Typical errors of ESP users

    Science.gov (United States)

    Eremina, Svetlana V.; Korneva, Anna A.

    2004-07-01

    The paper presents analysis of the errors made by ESP (English for specific purposes) users which have been considered as typical. They occur as a result of misuse of resources of English grammar and tend to resist. Their origin and places of occurrence have also been discussed.

  9. Evaluation of BRCA1 and BRCA2 mutations and risk-prediction models in a typical Asian country (Malaysia) with a relatively low incidence of breast cancer.

    Science.gov (United States)

    Thirthagiri, E; Lee, S Y; Kang, P; Lee, D S; Toh, G T; Selamat, S; Yoon, S-Y; Taib, N A Mohd; Thong, M K; Yip, C H; Teo, S H

    2008-01-01

    The cost of genetic testing and the limited knowledge about the BRCA1 and BRCA2 genes in different ethnic groups has limited its availability in medium- and low-resource countries, including Malaysia. In addition, the applicability of many risk-assessment tools, such as the Manchester Scoring System and BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm) which were developed based on mutation rates observed primarily in Caucasian populations using data from multiplex families, and in populations where the rate of breast cancer is higher, has not been widely tested in Asia or in Asians living elsewhere. Here, we report the results of genetic testing for mutations in the BRCA1 or BRCA2 genes in a series of families with breast cancer in the multi-ethnic population (Malay, Chinese and Indian) of Malaysia. A total of 187 breast cancer patients with either early-onset breast cancer (at age model and the Manchester Scoring System was significantly better for BRCA1 than BRCA2, but that the overall sensitivity, specificity and positive-predictive value was lower in this

  10. University Physics Students' Use of Models in Explanations of Phenomena Involving Interaction between Metals and Electromagnetic Radiation.

    Science.gov (United States)

    Redfors, Andreas; Ryder, Jim

    2001-01-01

    Examines third year university physics students' use of models when explaining familiar phenomena involving interaction between metals and electromagnetic radiation. Concludes that few students use a single model consistently. (Contains 27 references.) (DDR)

  11. Modelling and pathway identification involving the transport mechanism of a complex metabolic system in batch culture

    Science.gov (United States)

    Yuan, Jinlong; Zhang, Xu; Zhu, Xi; Feng, Enmin; Yin, Hongchao; Xiu, Zhilong

    2014-06-01

    The bio-dissimilation of glycerol to 1,3-propanediol (1,3-PD) by Klebsiella pneumoniae (K. pneumoniae) can be characterized by a complex metabolic system of interactions among biochemical fluxes, metabolic compounds, key enzymes and genetic regulation. In this paper, in consideration of the fact that the transport ways of 1,3-PD and glycerol with different weights across cell membrane are still unclear in batch culture, we consider 121 possible metabolic pathways and establish a novel mathematical model which is represented by a complex metabolic system. Taking into account the difficulty in accurately measuring the concentration of intracellular substances and the absence of equilibrium point for the metabolic system of batch culture, the novel approach used here is to define quantitatively biological robustness of the intracellular substance concentrations for the overall process of batch culture. To determine the most possible metabolic pathway, we take the defined biological robustness as cost function and establish an identification model, in which 1452 system parameters and 484 pathway parameters are involved. Simultaneously, the identification model is subject to the metabolic system, continuous state constraints and parameter constraints. As such, solving the identification model by a serial program is a very complicated task. We propose a parallel migration particle swarm optimization algorithm (MPSO) capable of solving the identification model in conjunction with the constraint transcription and smoothing approximation techniques. Numerical results show that the most possible metabolic pathway and the corresponding metabolic system can reasonably describe the process of batch culture.

  12. Linguistic recycling in typical and atypical interaction.

    Science.gov (United States)

    Perkins, Michael R

    2014-01-01

    I present evidence that linguistic "recycling" - i.e., the redeployment of linguistic material from prior utterances during conversation - is a striking and prevalent feature not only of interaction between typical speakers, but also, and notably, of interaction involving the communication impaired. In the latter case, recycling may sometimes be used as a compensatory communicative resource when linguistic ability is compromised. Despite its prevalence, however, recycling has largely been ignored by clinical linguists. In addition to providing illustrations of linguistic recycling across a range of communication disorders, I also examine how it is subserved by phenomena such as priming, short-term memory and alignment. I subsequently argue for a shift in perspective that puts recycling at the heart of our perception of how typical and atypical interaction works, and suggest a number of potential benefits for clinical linguistics, ranging from the way we understand and analyse communication disorders to how we assess and treat them.

  13. Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection

    Science.gov (United States)

    Anderson, Christopher S.; DeDiego, Marta L.; Topham, David J.; Thakar, Juilee

    2016-01-01

    Systems virology integrates host-directed approaches with molecular profiling to understand viral pathogenesis. Self-contained statistical approaches that combine expression profiles of genes with the available databases defining the genes involved in the pathways (gene-sets) have allowed characterization of predictive gene-signatures associated with outcome of the influenza virus (IV) infection. However, such enrichment techniques do not take into account interactions among pathways that are responsible for the IV infection pathogenesis. We investigate dendritic cell response to seasonal H1N1 influenza A/New Caledonia/20/1999 (NC) infection and infer the Boolean logic rules underlying the interaction network of ligand induced signaling pathways and transcription factors. The model reveals several novel regulatory modes and provides insights into mechanism of cross talk between NFκB and IRF mediated signaling. Additionally, the logic rule underlying the regulation of IL2 pathway that was predicted by the Boolean model was experimentally validated. Thus, the model developed in this paper integrates pathway analysis tools with the dynamic modeling approaches to reveal the regulation between signaling pathways and transcription factors using genome-wide transcriptional profiles measured upon influenza infection. PMID:26981147

  14. Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection

    Directory of Open Access Journals (Sweden)

    Christopher S. Anderson

    2016-01-01

    Full Text Available Systems virology integrates host-directed approaches with molecular profiling to understand viral pathogenesis. Self-contained statistical approaches that combine expression profiles of genes with the available databases defining the genes involved in the pathways (gene-sets have allowed characterization of predictive gene-signatures associated with outcome of the influenza virus (IV infection. However, such enrichment techniques do not take into account interactions among pathways that are responsible for the IV infection pathogenesis. We investigate dendritic cell response to seasonal H1N1 influenza A/New Caledonia/20/1999 (NC infection and infer the Boolean logic rules underlying the interaction network of ligand induced signaling pathways and transcription factors. The model reveals several novel regulatory modes and provides insights into mechanism of cross talk between NFκB and IRF mediated signaling. Additionally, the logic rule underlying the regulation of IL2 pathway that was predicted by the Boolean model was experimentally validated. Thus, the model developed in this paper integrates pathway analysis tools with the dynamic modeling approaches to reveal the regulation between signaling pathways and transcription factors using genome-wide transcriptional profiles measured upon influenza infection.

  15. Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection.

    Science.gov (United States)

    Anderson, Christopher S; DeDiego, Marta L; Topham, David J; Thakar, Juilee

    2016-01-01

    Systems virology integrates host-directed approaches with molecular profiling to understand viral pathogenesis. Self-contained statistical approaches that combine expression profiles of genes with the available databases defining the genes involved in the pathways (gene-sets) have allowed characterization of predictive gene-signatures associated with outcome of the influenza virus (IV) infection. However, such enrichment techniques do not take into account interactions among pathways that are responsible for the IV infection pathogenesis. We investigate dendritic cell response to seasonal H1N1 influenza A/New Caledonia/20/1999 (NC) infection and infer the Boolean logic rules underlying the interaction network of ligand induced signaling pathways and transcription factors. The model reveals several novel regulatory modes and provides insights into mechanism of cross talk between NFκB and IRF mediated signaling. Additionally, the logic rule underlying the regulation of IL2 pathway that was predicted by the Boolean model was experimentally validated. Thus, the model developed in this paper integrates pathway analysis tools with the dynamic modeling approaches to reveal the regulation between signaling pathways and transcription factors using genome-wide transcriptional profiles measured upon influenza infection.

  16. Modelling object typicality in description logics

    CSIR Research Space (South Africa)

    Britz, K

    2009-12-01

    Full Text Available base consists of a Tbox which contains terminological axioms, and an Abox which contains assertions, i.e. facts about specific named objects and rela- tionships between objects in the domain. Depending on the expressive power of the DL, a knowledge...”. An interpretation I satisfies C v D, written I C v D, iff CI ⊆ DI . C v D is valid, written |= C v D, iff it is satisfied by all interpretations. Rbox statements include role inclusions of the form R v S, and assertions used to define role proper- ties...

  17. Integrated supply chain inventory model with quality improvement involving controllable lead time and backorder price discount

    Directory of Open Access Journals (Sweden)

    Prashant Jindal

    2016-06-01

    Full Text Available For the past four decades the integrated vendor and buyer supply chain inventory model has been an interesting topic, but quality improvement of defective items in the integrated inventory model with backorder price discount involving controllable lead time has been rarely discussed. The aim of this paper is to minimize the total related cost in the continuous review model by considering the order quantity, reorder point, lead time, process quality, backorder price discount and number of shipment as decision variables. Moreover, we assume that an investment function is used to improve the process quality. The lead time demand follows a normal distribution. In addition, the buyer offers backorder price discount to motivate the customers for possible backorders. There are some defective items in the arrival lot, so its treatment is also taken in account in this paper. We develop an iterative procedure for finding the optimal values of decision variables and numerical example is presented to illustrate the solution procedure. Additionally, sensitivity analysis with respect to major parameters is also carried out.

  18. Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models

    Science.gov (United States)

    Santoyo-Sánchez, Mitzi; Thévenod, Frank; Barbier, Olivier

    2017-01-01

    Even decades after the discovery of Cadmium (Cd) toxicity, research on this heavy metal is still a hot topic in scientific literature: as we wrote this review, more than 1440 scientific articles had been published and listed by the PubMed.gov website during 2017. Cadmium is one of the most common and harmful heavy metals present in our environment. Since pregnancy is a very particular physiological condition that could impact and modify essential pathways involved in the handling of Cd, the prenatal life is a critical stage for exposure to this non-essential element. To give the reader an overview of the possible mechanisms involved in the multiple organ toxic effects in fetuses after the exposure to Cd during pregnancy, we decided to compile some of the most relevant experimental studies performed in experimental models and to summarize the advances in this field such as the Cd distribution and the factors that could alter it (diet, binding-proteins and membrane transporters), the Cd-induced toxicity in dams (preeclampsia, fertility, kidney injury, alteration in essential element homeostasis and bone mineralization), in placenta and in fetus (teratogenicity, central nervous system, liver and kidney). PMID:28737682

  19. Social Recovery Model: An 8-Year Investigation of Adolescent 12-step Group Involvement following Inpatient Treatment

    Science.gov (United States)

    Kelly, John F.; Brown, Sandra A.; Abrantes, Ana; Kahler, Christopher; Myers, Mark

    2013-01-01

    Background Despite widespread use of 12-step treatment approaches and referrals to Alcoholics Anonymous (AA) and Narcotics Anonymous (NA) by youth providers, little is known about the significance of these organizations in youth addiction recovery. Furthermore, existing evidence is based mostly on short-term follow-up and is limited methodologically. Methods Adolescent inpatients (N = 160; M age = 16, 40% female) were followed at 6-months, and at 1, 2, 4, 6, and 8 years post-treatment. Time-lagged, generalized estimating equations (GEE) modeled treatment outcome in relation to AA/NA attendance controlling for static and time-varying covariates. Robust regression (LOWESS) explored dose-response thresholds of AA/NA attendance on outcome. Results AA/NA attendance was common and intensive early post-treatment, but declined sharply and steadily over the 8-year period. Patients with greater addiction severity and those who believed they could not use substances in moderation were more likely to attend. Despite declining attendance, the effects related to AA/NA remained significant and consistent. Greater early participation was associated with better long-term outcomes. Conclusions Even though many youth discontinue AA/NA over time, attendees appear to benefit, and more severely substance-involved youth attend most. Successful early post-treatment engagement of youth in abstinence-supportive social contexts, such as AA/NA, may have long-term implications for alcohol and drug involvement into young adulthood. PMID:18557829

  20. The emission of α,ω-diphenylpolyenes: A model involving several molecular structures

    Science.gov (United States)

    Catalán, Javier

    2007-05-01

    Available photophysical evidence for the emission of α,ω-diphenylpolyenes is shown to be consistent with a previously reported model [J. Catalán, J.L.G. de Paz, J. Chem. Phys. 124 (2006) 034306] involving two electronically excited molecular structures of 1B u and C s symmetry, respectively. The 1B u structure is produced by direct light absorption from the all- trans form of the α,ω-diphenylpolyene in the ground state and its emission exhibits mirror symmetry with respect to the absorption of the compound. On the other hand, the C s structure is generated from the 1B u structure of the α,ω-diphenylpolyene by rotation about a C-C single bond in the polyene chain, its emission being red-shifted with respect to the previous one and exhibiting markedly decreased vibrational structure. At room temperature, both emissions give the excitation spectrum, which are ascribed to the first absorption band for the compound. It is shown that some polyenes may exist in more than one structure of C s symmetry in the excited electronic state with lower energy than that of the 1B u state, from which the C s structures are produced. Hence, more than one electronic structure may be involved in the deactivation processes of the 1B u state, which is initially populated upon photo-excitation of the polyene molecule in the ground electronic state.

  1. An EMQ inventory model for defective products involving rework and sales team's initiatives-dependent demand

    Science.gov (United States)

    Priyan, S.; Uthayakumar, R.

    2015-07-01

    This paper investigates the issue of an economic manufacturing quantity model for defective products involving imperfect production processes and rework. We consider that the demand is sensitive to promotional efforts/sales teams' initiatives as well as the setup cost can be reduced through further investment. It also assumes that fixed quantity multiple installments of the finished batch are delivered to customers at a fixed interval of time. The long-run average cost function is derived and its convexity is proved via differential calculus. An effective iterative solution procedure is developed to achieve optimal replenishment lot-size, setup cost and the initiatives of sales teams so that the total cost of system is minimized. Numerical and sensitivity analyses are performed to evaluate the outcome of the proposed solution procedure presented in this research.

  2. System Dynamics Modelling of the Processes Involving the Maintenance of the Naive T Cell Repertoire

    CERN Document Server

    Figueredo, Grazziela P; Whitbrook, Amanda

    2010-01-01

    The study of immune system aging, i.e. immunosenescence, is a relatively new research topic. It deals with understanding the processes of immunodegradation that indicate signs of functionality loss possibly leading to death. Even though it is not possible to prevent immunosenescence, there is great benefit in comprehending its causes, which may help to reverse some of the damage done and thus improve life expectancy. One of the main factors influencing the process of immunosenescence is the number and phenotypical variety of naive T cells in an individual. This work presents a review of immunosenescence, proposes system dynamics modelling of the processes involving the maintenance of the naive T cell repertoire and presents some preliminary results.

  3. Processes and parameters involved in modeling radionuclide transport from bedded salt repositories. Final report. Technical memorandum

    Energy Technology Data Exchange (ETDEWEB)

    Evenson, D.E.; Prickett, T.A.; Showalter, P.A.

    1979-07-01

    The parameters necessary to model radionuclide transport in salt beds are identified and described. A proposed plan for disposal of the radioactive wastes generated by nuclear power plants is to store waste canisters in repository sites contained in stable salt formations approximately 600 meters below the ground surface. Among the principal radioactive wastes contained in these canisters will be radioactive isotopes of neptunium, americium, uranium, and plutonium along with many highly radioactive fission products. A concern with this form of waste disposal is the possibility of ground-water flow occurring in the salt beds and endangering water supplies and the public health. Specifically, the research investigated the processes involved in the movement of radioactive wastes from the repository site by groundwater flow. Since the radioactive waste canisters also generate heat, temperature is an important factor. Among the processes affecting movement of radioactive wastes from a repository site in a salt bed are thermal conduction, groundwater movement, ion exchange, radioactive decay, dissolution and precipitation of salt, dispersion and diffusion, adsorption, and thermomigration. In addition, structural changes in the salt beds as a result of temperature changes are important. Based upon the half-lives of the radioactive wastes, he period of concern is on the order of a million years. As a result, major geologic phenomena that could affect both the salt bed and groundwater flow in the salt beds was considered. These phenomena include items such as volcanism, faulting, erosion, glaciation, and the impact of meteorites. CDM reviewed all of the critical processes involved in regional groundwater movement of radioactive wastes and identified and described the parameters that must be included to mathematically model their behavior. In addition, CDM briefly reviewed available echniques to measure these parameters.

  4. Involvement of EphB1 receptors signalling in models of inflammatory and neuropathic pain.

    Directory of Open Access Journals (Sweden)

    Vincent Cibert-Goton

    Full Text Available EphB receptors tyrosine kinases and ephrinB ligands were first identified as guidance molecules involved in the establishment of topographical mapping and connectivity in the nervous system during development. Later in development and into adulthood their primary role would switch from guidance to activity-dependent modulation of synaptic efficacy. In sensory systems, they play a role in both the onset of inflammatory and neuropathic pain, and in the establishment of central sensitisation, an NMDA-mediated form of synaptic plasticity thought to underlie most forms of chronic pain. We studied wild type and EphB1 knockout mice in a range of inflammatory and neuropathic pain models to determine 1, whether EphB1 expression is necessary for the onset and/or maintenance of persistent pain, regardless of origin; 2, whether in these models cellular and molecular changes, e.g. phosphorylation of the NR2B subunit of the NMDA receptor, increased c-fos expression or microglial activation, associated with the onset of pain, are affected by the lack of functional EphB1 receptors. Differences in phenotype were examined behaviourally, anatomically, biochemically and electrophysiologically. Our results establish firstly, that functional EphB1 receptors are not essential for the development of normal nociception, thermal or mechanical sensitivity. Secondly, they demonstrate a widespread involvement of EphB1 receptors in chronic pain. NR2B phosphorylation, c-fos expression and microglial activation are all reduced in EphB1 knockout mice. This last finding is intriguing, since microglial activation is supposedly triggered directly by primary afferents, therefore it was not expected to be affected. Interestingly, in some models of long-term pain (days, mechanical and thermal hyperalgesia develop both in wild type and EphB1 knockout mice, but recovery is faster in the latter, indicating that in particular models these receptors are required for the maintenance

  5. Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).

    Science.gov (United States)

    Pajeva, Ilza K; Wiese, Michael

    2002-12-19

    A general pharmacophore model of P-glycoprotein (P-gp) drugs is proposed that is based on a highly diverse data set and relates to the verapamil binding site of the protein. It is derived from structurally different drugs using the program GASP. The pharmacophore model consists of two hydrophobic points, three hydrogen bond (HB) acceptor points, and one HB donor point. Pharmacophore patterns of various drugs are obtained, and different binding modes are presumed for some of them. It is concluded that the binding affinity of the drugs depends on the number of the pharmacophore points simultaneously involved in the interaction with P-gp. On the basis of the obtained results, a hypothesis is proposed to explain the broad structural variety of the P-gp substrates and inhibitors: (i) the verapamil binding site of P-gp has several points that can participate in hydrophobic and HB interactions; (ii) different drugs can interact with different receptor points in different binding modes.

  6. A structural model of customer satisfaction and trust in vendors involved in mobile commerce

    Directory of Open Access Journals (Sweden)

    Suki, N.M.

    2011-01-01

    Full Text Available The purpose of this paper is to provide an explanation of factors influencing customer satisfaction and trust in vendors involved in mobile commerce (m-commerce. The study sample consists of 200 respondents. Data were analyzed by employing structural equation modelling (SEM supported by AMOS 5.0 with maximum likelihood estimation in order to test the proposed hypotheses. The proposed model was empirically tested and results confirmed that users’ satisfaction with vendors in m-commerce was not significantly influenced by two antecedents of the vendor’s website quality: interactivity and customisation, and also two antecedents of mobile technology quality: usefulness and ease-of-use. Meanwhile, users’ trust towards the vendor in m-commerce is affected by users’ satisfaction with the vendor. Interestingly, vendor quality dimensions such as responsiveness and brand image influence customer satisfaction with vendors in m-commerce. Based on the findings, vendors in m-commerce should focus on the factors which generate more satisfaction and trust among customers. For vendors in general, the results can help them to better develop customer trust in m-commerce. Vendors of m-commerce can provide a more satisfying experience for customers.

  7. Involving mental health service users in suicide-related research: a qualitative inquiry model.

    Science.gov (United States)

    Lees, David; Procter, Nicholas; Fassett, Denise; Handley, Christine

    2016-03-01

    To describe the research model developed and successfully deployed as part of a multi-method qualitative study investigating suicidal service-users' experiences of mental health nursing care. Quality mental health care is essential to limiting the occurrence and burden of suicide, however there is a lack of relevant research informing practice in this context. Research utilising first-person accounts of suicidality is of particular importance to expanding the existing evidence base. However, conducting ethical research to support this imperative is challenging. The model discussed here illustrates specific and more generally applicable principles for qualitative research regarding sensitive topics and involving potentially vulnerable service-users. Researching into mental health service users with first-person experience of suicidality requires stakeholder and institutional support, researcher competency, and participant recruitment, consent, confidentiality, support and protection. Research with service users into their experiences of sensitive issues such as suicidality can result in rich and valuable data, and may also provide positive experiences of collaboration and inclusivity. If challenges are not met, objectification and marginalisation of service-users may be reinforced, and limitations in the evidence base and service provision may be perpetuated.

  8. An ODE for an overloaded X model involving a stochastic averaging principle

    Directory of Open Access Journals (Sweden)

    Ward Whitt

    2011-01-01

    Full Text Available We study an ordinary differential equation (ODE arising as the many-server heavy-traffic fluid limit of a sequence of overloaded Markovian queueing models with two customer classes and two service pools. The system, known as the X model in the call-center literature, operates under the fixed-queue-ratio-with-thresholds (FQR-T control, which we proposed in a recent paper as a way for one service system to help another in face of an unanticipated overload. Each pool serves only its own class until a threshold is exceeded; then one-way sharing is activated with all customer-server assignments then driving the two queues toward a fixed ratio. For large systems, that fixed ratio is achieved approximately. The ODE describes system performance during an overload. The control is driven by a queue-difference stochastic process, which operates in a faster time scale than the queueing processes themselves, thus achieving a time-dependent steady state instantaneously in the limit. As a result, for the ODE, the driving process is replaced by its long-run average behavior at each instant of time; i.e., the ODE involves a heavy-traffic averaging principle (AP.

  9. Yeast Mitochondrial Interactosome Model: Metabolon Membrane Proteins Complex Involved in the Channeling of ADP/ATP

    Directory of Open Access Journals (Sweden)

    Benjamin Clémençon

    2012-02-01

    Full Text Available The existence of a mitochondrial interactosome (MI has been currently well established in mammalian cells but the exact composition of this super-complex is not precisely known, and its organization seems to be different from that in yeast. One major difference is the absence of mitochondrial creatine kinase (MtCK in yeast, unlike that described in the organization model of MI, especially in cardiac, skeletal muscle and brain cells. The aim of this review is to provide a detailed description of different partner proteins involved in the synergistic ADP/ATP transport across the mitochondrial membranes in the yeast Saccharomyces cerevisiae and to propose a new mitochondrial interactosome model. The ADP/ATP (Aacp and inorganic phosphate (PiC carriers as well as the VDAC (or mitochondrial porin catalyze the import and export of ADP, ATP and Pi across the mitochondrial membranes. Aacp and PiC, which appear to be associated with the ATP synthase, consist of two nanomotors (F0, F1 under specific conditions and form ATP synthasome. Identification and characterization of such a complex were described for the first time by Pedersen and co-workers in 2003.

  10. Review of typical cognitive models and their application in human reliability analysis%典型认知模型及其在人因可靠性分析中的应用评述

    Institute of Scientific and Technical Information of China (English)

    蒋英杰; 孙志强; 李龙; 宫二玲; 谢红卫

    2011-01-01

    评述了典型认知模型及其在人因可靠性分析中的应用.首先,强调了在人因可靠性分析中使用认知模型的必要性; 然后,介绍了认知心理学、行为科学等学科所建立的几种典型认知模型,包括信息处理模型、决策过程的阶梯模型和通用认知模型,分别分析了它们的基本结构和功能,讨论了各自的优缺点; 随后,介绍了几种人因可靠性分析方法中所建立或使用的认知模型,包括HCR方法使用的SRK框架、ATHEANA方法使用的信息处理模型、CREAM方法建立的COCOM模型以及IDAC方法构建的IDA模型,分别分析了这些模型的特点; 最后,提出了建立认知模型所要遵循的基本原则,并展望了认知模型的未来发展方向.%The typical cognitive models and their applications in human reliability analysis are reviewed. Firstly, emphasis is placed on the necessity to establish cognitive models in human reliability analysis. Cognitive model can simplify the human behavior and abstract the general structure of human cognitive process. On the other hand,cognitive model can be used as the basis of human error interpretation. Secondly, several typical cognitive models in cognitive psychology and behavior science are reviewed, which are information process model, step model of decision making process and general cognitive model. Their basic structures and functions are analyzed. Meanwhile, their strong points and shortcomings are discussed as well. It is pointed out that the structure of cognitive models is increasingly closer to the real world and these models are more and more applicable. Thirdly, the cognitive models in several human reliability analysis methods are introduced, which are SRK framework of HCR, information process model of ATHEANA, COCOM model of CREAM and IDA model of IADC. Their characteristics are analyzed respectively.Lasfiy, the basic principles to establish cognitive models are proposed where the human cognitive

  11. Modeling economic costs of disasters and recovery involving positive effects of reconstruction: analysis using a dynamic CGE model

    Directory of Open Access Journals (Sweden)

    W. Xie

    2013-11-01

    Full Text Available Disaster damages have negative effects on economy, whereas reconstruction investments have positive effects. The aim of this study is to model economic causes of disasters and recovery involving positive effects of reconstruction activities. Computable general equilibrium (CGE model is a promising approach because it can incorporate these two kinds of shocks into a unified framework and further avoid double-counting problem. In order to factor both shocks in CGE model, direct loss is set as the amount of capital stock reduced on supply side of economy; A portion of investments restore the capital stock in existing period; An investment-driven dynamic model is formulated due to available reconstruction data, and the rest of a given country's saving is set as an endogenous variable. The 2008 Wenchuan Earthquake is selected as a case study to illustrate the model, and three scenarios are constructed: S0 (no disaster occurs, S1 (disaster occurs with reconstruction investment and S2 (disaster occurs without reconstruction investment. S0 is taken as business as usual, and the differences between S1 and S0 and that between S2 and S0 can be interpreted as economic losses including reconstruction and excluding reconstruction respectively. The study showed that output from S1 is found to be closer to real data than that from S2. S2 overestimates economic loss by roughly two times that under S1. The gap in economic aggregate between S1 and S0 is reduced to 3% in 2011, a level that should take another four years to achieve under S2.

  12. Involvement of Autophagic Pathway in the Progression of Retinal Degeneration in a Mouse Model of Diabetes.

    Science.gov (United States)

    Piano, Ilaria; Novelli, Elena; Della Santina, Luca; Strettoi, Enrica; Cervetto, Luigi; Gargini, Claudia

    2016-01-01

    The notion that diabetic retinopathy (DR) is essentially a micro-vascular disease has been recently challenged by studies reporting that vascular changes are preceded by signs of damage and loss of retinal neurons. As to the mode by which neuronal death occurs, the evidence that apoptosis is the main cause of neuronal loss is far from compelling. The objective of this study was to investigate these controversies in a mouse model of streptozotocin (STZ) induced diabetes. Starting from 8 weeks after diabetes induction there was loss of rod but not of cone photoreceptors, together with reduced thickness of the outer and inner synaptic layers. Correspondingly, rhodopsin expression was downregulated and the scotopic electroretinogram (ERG) is suppressed. In contrast, cone opsin expression and photopic ERG response were not affected. Suppression of the scotopic ERG preceded morphological changes as well as any detectable sign of vascular alteration. Only sparse apoptotic figures were detected by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and glia was not activated. The physiological autophagy flow was altered instead, as seen by increased LC3 immunostaining at the level of outer plexiform layer (OPL) and upregulation of the autophagic proteins Beclin-1 and Atg5. Collectively, our results show that the streptozotocin induced DR in mouse initiates with a functional loss of the rod visual pathway. The pathogenic pathways leading to cell death develop with the initial dysregulation of autophagy well before the appearance of signs of vascular damage and without strong involvement of apoptosis.

  13. The Oskarshamn model for public involvement in the siting of nuclear facilities

    Energy Technology Data Exchange (ETDEWEB)

    Aahagen, H. [Ahagen and Co (Sweden); CarIsson, Torsten [Mayor, Oskarshamn (Sweden); Hallberg, K. [Local Competence Building, Oskarshamn (Sweden); Andersson, Kjell [Karinta-Konsult, Taeby(Sweden)

    1999-12-01

    The Oskarshamn model has so far worked extremely well as a tool to achieve openness and public participation. The municipality involvement has been successful in several aspects, e.g.: It has been possible to influence the program, to a large extent, to meet certain municipality conditions and to ensure the local perspective. The local competence has increased to a considerable degree. The activities generated by the six working groups with a total of 40 members have generated a large number of contacts with various organisations, schools, mass media, individuals in the general public and interest groups. For the future, clarification of the disposal method and site selection criteria as well as the site selection process as such is crucial. The municipality has also emphasised the importance of SKB having shown the integration between site selection criteria, the feasibility study and the safety assessment. Furthermore, the programs for the encapsulation facility and the repository must be co-ordinated. For Oskarshamn it will be of utmost importance that the repository is well under way to be realised before the encapsulation facility can be built.

  14. Association of father involvement and neighborhood quality with kindergartners' physical activity: a multilevel structural equation model.

    Science.gov (United States)

    Beets, Michael W; Foley, John T

    2008-01-01

    Examine the effects of father-child involvement and neighborhood characteristics with young children's physical activity (PA) within a multilevel framework. Cross-sectional analysis of the Early Childhood Longitudinal Study-Kindergarten Cohort 1998. Nationally representative sample. Data were available for 10,694 kindergartners (5-6 years; 5240 girls) living in 1053 neighborhoods. Parental report of child's PA level, father characteristics (e.g., time spent with child, age, education, socioeconomic status, hours worked), family time spent doing sports/ activities together, and neighborhood quality (e.g., safety, presence of crime violence, garbage). Child weight status, motor skills, ethnicity, and television viewing were used as covariates. Multilevel structural equation modeling with children nested within neighborhoods. At the child level father-child time and family time doing sports together were positively associated with children's PA. At the neighborhood level parental perception of a neighborhood's safety for children to play outside fully mediated the effect of neighborhood quality on children's PA. Overall 19.1% and 7.6% of the variance in PA was explained at the child and neighborhood levels, respectively. Family-based interventions for PA should consider father-child time, with this contributing to a child's overall PA level. Further, neighborhood quality is an important predictor of PA only to the extent by which parents perceive it to be unsafe for their child to play outdoors.

  15. Characterization of Pneumococcal Genes Involved in Bloodstream Invasion in a Mouse Model.

    Directory of Open Access Journals (Sweden)

    Layla K Mahdi

    Full Text Available Streptococcus pneumoniae (the pneumococcus continues to account for significant morbidity and mortality worldwide, causing life-threatening diseases such as pneumonia, bacteremia and meningitis, as well as less serious infections such as sinusitis, conjunctivitis and otitis media. Current polysaccharide vaccines are strictly serotype-specific and also drive the emergence of non-vaccine serotype strains. In this study, we used microarray analysis to compare gene expression patterns of either serotype 4 or serotype 6A pneumococci in the nasopharynx and blood of mice, as a model to identify genes involved in invasion of blood in the context of occult bacteremia in humans. In this manner, we identified 26 genes that were significantly up-regulated in the nasopharynx and 36 genes that were significantly up-regulated in the blood that were common to both strains. Gene Ontology classification revealed that transporter and DNA binding (transcription factor activities constitute the significantly different molecular functional categories for genes up-regulated in the nasopharynx and blood. Targeted mutagenesis of selected genes from both niches and subsequent virulence and pathogenesis studies identified the manganese-dependent superoxide dismutase (SodA as most likely to be essential for colonization, and the cell wall-associated serine protease (PrtA as important for invasion of blood. This work extends our previous analyses and suggests that both PrtA and SodA warrant examination in future studies aimed at prevention and/or control of pneumococcal disease.

  16. 几种常用似大地水准面插值方法精度分析%Several Typical Interpolation Method and its Precision Analysis Based on Quasi-Geoid Model

    Institute of Scientific and Technical Information of China (English)

    徐平; 杜向锋

    2014-01-01

    This article details several typical mathematical models of the interpolation methods of quasi-geoid,and compiles the corresponding model interpolation software on the basis of these models.Meanwhile,by using the interpolation methods provided by the inter-polation software and a certain quasi-geoid model,some GPS/leveling data are calculated by using elevation interpolation.Through the analysis of the interpolation results,some useful conclusions are drawn.%详细介绍了几种常用的似大地水准面插值方法的数学模型,并根据这些模型编写了相应的模型内插软件,利用该内插软件提供的内插方法及某似大地水准面模型,对一些GPS/水准数据进行了高程内插计算,通过对内插结果的分析获得了一些有益的结论。

  17. Harnessing and supporting consumer involvement in the development and implementation of Models of Care for musculoskeletal health.

    Science.gov (United States)

    Walsh, Louisa; Hill, Sophie; Wluka, Anita E; Brooks, Peter; Buchbinder, Rachelle; Cahill, Ainslie; Dans, Leonila F; Lowe, Dianne; Taylor, Michael; Tugwell, Peter

    2016-06-01

    Consumer involvement in the design and delivery of their healthcare is an integral strategy to ensure that health services and systems meet consumers' needs. This is also true for the design and delivery of Models of Care. This chapter presents the identified healthcare needs of people with musculoskeletal conditions and focuses on the current systematic review evidence for consumer involvement interventions in musculoskeletal Models of Care across the micro, meso and macro levels of healthcare. This chapter also presents three case studies of consumer involvement in different aspects of healthcare, offers a series of practice points to help translate the systematic review evidence into practice, and also provides direction to available resources, which support the implementation of consumer involvement within Models of Care.

  18. Discussed on Typical Cases of Bilingual Teaching Model in Xinjiang Primary Schools%新疆双语教学模式(小学)典型案例分析。

    Institute of Scientific and Technical Information of China (English)

    曹春梅

    2012-01-01

    通过对新疆双语教学模式的三个典型案例的分析,提出了作为母语教学的汉语文教学和作为第二语言教学的汉语教学的差异,并对两者的适应性改进提出了作者的看法。%The essay is proposed the differences between Chinese language and literature teaching as the mother tongue and Chinese language teaching as the second language by analysis of three typical cases of bilingual teaching model in Xinjiang, and How to integrate the differences of two language teachings have been discussed.

  19. The Brain’s sense of walking: a study on the intertwine between locomotor imagery and internal locomotor models in healthy adults, typically developing children and children with cerebral palsy

    Directory of Open Access Journals (Sweden)

    Marco eIosa

    2014-10-01

    Full Text Available Motor imagery and internal motor models have been deeply investigated in literature. It is well known that the development of motor imagery occurs during adolescence and it is limited in people affected by cerebral palsy. However, the roles of motor imagery and internal models in locomotion as well as their intertwine received poor attention. In this study we compared the performances of healthy adults (n=8, 28.1±5.1 years old, children with typical development (n=8, 8.1±3.8 years old and children with cerebral palsy (n=12, 7.5±2.9 years old, measured by an optoelectronic system and a trunk-mounted wireless inertial magnetic unit, during three different tasks. Subjects were asked to achieve a target located at 2 or 3m in front of them simulating their walking by stepping in place, or actually walking blindfolded or normally walking with open eyes. Adults performed a not significantly different number of steps (p=0.761 spending not significantly different time between tasks (p=0.156. Children with typical development showed task-dependent differences both in terms of number of steps (p=0.046 and movement time (p=0.002. However, their performance in simulated and blindfolded walking were strictly correlated (R=0.871 for steps, R=0.673 for time. Further, their error in blindfolded walking was in mean only of -2.2% of distance. Also children with cerebral palsy showed significant differences in number of steps (p=0.022 and time (p<0.001, but neither their number of steps nor their movement time recorded during simulated walking were found correlated with those of blindfolded and normal walking. Adults used a unique strategy among different tasks. Children with typical development seemed to be less reliable on their motor predictions, using a task-dependent strategy probably more reliable on sensorial feedback. Children with cerebral palsy showed less efficient performances, especially in simulated walking, suggesting an altered locomotor imagery.

  20. Youth spare time: Typical patterns of behavior

    Directory of Open Access Journals (Sweden)

    Stepanović Ivana

    2009-01-01

    Full Text Available In this research we have tried to identify typical patterns of young people's behavior in their spare time and to use these patterns in order to group our subjects regarding their interests and preferences. Main-component analysis showed that it was possible to find different patterns of secondary school students' behavior in spare time as well as that the identified models could be the criteria for grouping them. Five patterns have been identified describing youth orientations towards their free time: academic orientation, orientation towards sports, orientation towards entertainment, orientation towards spending time going out and orientation towards music and computers.

  1. PTL: A Propositional Typicality Logic

    CSIR Research Space (South Africa)

    Booth, R

    2012-09-01

    Full Text Available in which a formula holds. The semantics is in terms of ranked models as studied in KLM-style preferential reasoning. This allows us to show that rational consequence relations can be embedded in our logic. Moreover we show that we can define consequence...

  2. [Typical forms of schizophrenia in old age].

    Science.gov (United States)

    Sternberg, E; Konzewoi, V

    1978-01-01

    Aside from typical forms of late schizophrenia which generally conform to the definition given by M. Bleuler, there also are psychoses appearing in old age which differ significantly from the atypical symptoms and consequently present certain diagnostic difficulties. This report contains descriptions of late manifestations in schizophrenic psychoses, which develop with a continuous or assault-like course with a prevalence of parnoial disorders. Paranoid delusions, in such cases, are characterized by aging traits (concrete and short-term delusions, exaggeration of the degree of superficial persecution and prejudice, and a limited number of people involved in the delusions). The development of such forms of late schizophrenia takes a slowly progressing course. The results of these studies, especially the psychopathological symptomatology, the genetic-constitutional background and the development and outcome of these psychoses are analyzed in detail. The data permit to consider such forms of psychose as atypical variants of late schizophrenia.

  3. Typical and Atypical Manifestations of Intrathoracic Sarcoidosis

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hyun Jin; Jung, Jung Im; Chung, Myung Hee; Song, Sun Wha; Kim, Hyo Lim; Baik, Jun Hyun; Han, Dae Hee [St. Vincent' s Hospital, The Catholic University of Korea, Suwon (Korea, Republic of); Kim, Ki Jun [Incheon St. Mary' s Hospital, The Catholic University of Korea, Incheon (Korea, Republic of); Lee, Kyo Young [Seoul St. Mary' s Hospital, The Catholic University of Korea, Seoul (Korea, Republic of)

    2009-12-15

    Sarcoidosis is a systemic disorder of unknown cause that is characterized by the presence of noncaseating granulomas. The radiological findings associated with sarcoidosis have been well described. The findings include symmetric, bilateral hilar and paratracheal lymphadenopathy, with or without concomitant parenchymal abnormalities (multiple small nodules in a peribronchovascular distribution along with irregular thickening of the interstitium). However, in 25% to 30% of cases, the radiological findings are atypical and unfamiliar to most radiologists, which cause difficulty for making a correct diagnosis. Many atypical forms of intrathoracic sarcoidosis have been described sporadically. We have collected cases with unusual radiological findings associated with pulmonary sarcoidosis (unilateral or asymmetric lymphadenopathy, necrosis or cavitation, large opacity, ground glass opacity, an airway abnormality and pleural involvement) and describe the typical forms of the disorder as well. The understanding of a wide range of the radiological manifestations of sarcoidosis will be very helpful for making a proper diagnosis.

  4. Smart Campus Construction Over all Architecture Model and Typical Applications Prospects%智慧校园建设总体架构模型及典型应用分析

    Institute of Scientific and Technical Information of China (English)

    王燕

    2014-01-01

    智慧校园是信息化发展的新阶段。在从数字校园到智慧校园的建设过程中,加强智慧校园的顶层设计,构建智慧校园建设的通用架构模型具有十分重要的意义。在智慧校园中开展典型应用对于推动智慧校园的建设和应用进程具有良好的示范带动作用。为了探索智慧校园的建设模式,该文在分析智慧校园的内涵特征和关键技术的基础上,设计了智慧校园建设总体架构模型。该模型从下到上依次分为感知层、网络层、数据层、应用层和服务层,通过构建信息标准与规范体系、运行维护与安全体系来保障智慧校园的规范建设与运行维护;然后从智慧教育、智慧科研和智慧管理方面分析了智慧校园的典型应用,为智慧校园的示范推广应用提供参考。%Smart campus is a new stage of development of information technology. From the digital campus to the smart campus, it has very important signiifcance that strengthens the top-level design of smart campus and builds the overall architecture model of smart campus. Typical applications carried out in the smart campus has a good role model to promote the construction and application process for the smart campus. In order to explore the construction mode of smart campus, the overall architecture model is designed based on the analysis of connotation characteristics and key technologies of smart campus, which includes the perception layer, network layer, data layer, application layer and service layer from bottom to top. Construction standard and operation maintenance of smart campus is ensured through information Standards, Standard system, Operation maintenance and Security system. Finally this paper prospects typical applications of smart campus through smart teachings, smart experiment ,smart research and smart management.

  5. Modelling skin surface areas involved in water transfer in the Palmate Newt (Lissotriton helveticus)

    National Research Council Canada - National Science Library

    Wardziak, Thomas; Oxarango, Laurent; Valette, Sebastien; Mahieu-Williame, Laurent; Joly, Pierre

    2014-01-01

    Magnetic resonance imaging (MRI) based 3D reconstructions were used to derive accurate quantitative data on body volume and functional skin surface areas involved in water transfer in the Palmate Newt...

  6. Analysis and Modeling of Pedestrian Walking Behaviors Involving Individuals with Disabilities

    OpenAIRE

    Sharifi, Mohammad Sadra

    2016-01-01

    The objective of this dissertation was to study walking behaviors of pedestrian groups involving individuals with disabilities. To this end, large scale controlled walking experiments were conducted at Utah State University (USU) to examine walking behaviors in various walking facility types, such as passageway, right angle, oblique angle, queuing area, bottleneck, and stairs. Walking experiments were conducted over four days involving participants with and without disabilities. Automated vid...

  7. 混合模式下的农业机械载荷谱数据管理系统%Realization of Load Spectrum Data Management System for Typical Agricultural Machinery Based on Hybrid Model

    Institute of Scientific and Technical Information of China (English)

    孟庆瑞; 田兆锋; 张书明; 阎楚良

    2009-01-01

    Against the background of implementing load spectrum data management system of the typical agricultural machinery, the load spectrum data management system was designed and implemented using the technology of . NET in the mixed model of C/S and B/S. Then overall plan and structure model of the system were worked out according to actual situation and detailed requirements of engineering application. Finally, each system module was coded and debugged. Thus, it can be implemented for the modernization management of load spectrum data, adding communication channels and improving efficiency of structural fatigue research.%以拖拉机、联合收获机等典型农业机械载荷谱数据库建设工作为背景,基于B/S与C/S混合模式,利用.NET技术体系设计与实现载荷谱数据库信息管理系统.针对实际情况和工程应用的具体需求制定了系统的总体方案,设计了系统的结构模型,最后完成系统具体模块的开发调试.系统可实现载荷谱数据现代化管理、增加信息沟通渠道、提高结构疲劳寿命研究工作的效率.

  8. TLR4 is involved in the pathogenic effects observed in a murine model of antiphospholipid syndrome.

    Science.gov (United States)

    Xie, Hongxiang; Kong, Xiangmin; Zhou, Hong; Xie, Yachao; Sheng, Liangju; Wang, Ting; Xia, Longfei; Yan, Jinchuan

    2015-10-01

    Antiphospholipid (aPL)/anti-β2-glycoprotein I (β2GPI) antibodies are considered to play a pivotal pathogenic role in antiphospholipid syndrome (APS) by inducing an intracellular signaling and procoagulant/proinflammatory phenotype that leads to thrombosis. There is increasing evidence that Toll-like receptor 4 (TLR4) could serve as an important molecule for anti-β2GPI recognition on target cells. However, few studies have focused on the effects of TLR4 in in vivo models. Here, we investigated the role of TLR4 in the pathogenic effects of aPL/anti-β2GPI more precisely using TLR4-intact (C3H/HeN) and TLR4-defective (C3H/HeJ) mice. C3H/HeN and C3H/HeJ mice were injected with either IgG isolated from patient with APS (IgG-APS) or epitope-specific anti-β2GPI purified from β2GPI peptide-immunized rabbits. We found that, following anti-β2GPI injections and vascular injury, thrombus formation in both the carotid artery and femoral vein was markedly reduced in C3H/HeJ mice when compared with C3H/HeN mice. IgG-APS or anti-β2GPI-induced carotid artery and peritoneal macrophage tissue factor activity/expression was significantly lesser in C3H/HeJ than in C3H/HeN mice. Furthermore, the IgG-APS or anti-β2GPI induced expression of VCAM-1, ICAM-1, and E-selectin in the aorta and of IL-1β, IL-6, and TNF-α in peritoneal macrophages of C3H/HeJ mice was also significantly reduced compared to C3H/HeN mice. Together, these data suggest that TLR4 is involved in the pathogenic effects of aPL/anti-β2GPI antibodies in vivo.

  9. Development and Validation of a Needs Assessment Model Using Stakeholders Involved in a University Program.

    Science.gov (United States)

    Labrecque, Monique

    1999-01-01

    Developed a needs-assessment model and validated the model with five groups of stakeholders connected with an undergraduate university nursing program in Canada. Used focus groups, questionnaires, a hermeneutic approach, and the magnitude-estimation scaling model to validate the model. Results show that respondents must define need to clarify the…

  10. Compatibility in the Biomphalaria glabrata/Echinostoma caproni model: potential involvement of adhesion genes.

    Science.gov (United States)

    Bouchut, A; Roger, E; Coustau, C; Gourbal, B; Mitta, G

    2006-02-01

    Because susceptibility or resistance of Biomphalaria glabrata to the trematode Echinostoma caproni correlates with differential hemocytic adhesive properties, we compared the expression of genes involved in adhesion processes between hemocytes from susceptible and resistant snails. Quantitative reverse transcriptase-PCR analysis revealed four genes whose transcripts were differentially represented between hemocytes from resistant and susceptible snails. These genes encode two dermatopontin-like, one matrilin-like and one cadherin-like proteins. Expression analyses performed following parasite exposure suggested that dermatopontins may be involved in the compatibility differences between these strains. We also investigated expression levels on whole snails of different genes potentially involved in extracellular matrix structure or coagulation. Our results support the hypothesis that susceptible snails possess a hemolymph coagulation-like system that is more potent than that of resistant snails. This system may prevent hemocyte migration towards the parasite larvae and therefore facilitate parasite settlement in susceptible snails.

  11. Soil Characteristics Under Typical Agroforestry Model in Northwestern Areas%辽西北地区典型农林复合模式下土壤特性研究

    Institute of Scientific and Technical Information of China (English)

    王娇

    2014-01-01

    Research of four typical agroforestry models on soil improvement in northwestern areas was conducted .Re-sult shows that :relative to the control primitive wasteland ,agroforestry model have characteristics of reducing soil bulk density ,increasing soil water holding capacity ,soil porosity and so on ,while improving soil fertility ,increasing the soil nitrogen ,phosphorus ,potassium content ,improving organic matter content .Comprehensive evaluation of soil quality shows that :in the agroforestry model ,Prunus sibirica var .suavosperma- A rachis hypogaea- Zea mays have the optimal effect on soil improvement ;Prunus sibirica var .suavosperma- Ephedra sinica ,followed by Pinus sylvestris var .mongolica- Arachis hypogaea .On soil depth ,the soil improvement effect of model for Prunus sibirica var .suavosperma - A rachis hypogaea- Zea mays and the model of Prunus sibirica var .suavosperma-Ephedra sinica in 0-20 cm soil layer are optimal than that in 20-40 cm soil layer ;the result of the model for Pinus sylvestris- A rachis hypogaea is opposite .%通过对辽西北地区4种典型农林复合模式对土壤改良的研究,结果显示,相对于对照原始荒地,农林复合模式具有降低土壤容重,增加土壤持水量、土壤孔隙度等作用,同时改善土壤肥力,增大土壤内氮、磷、钾含量,提升有机质含量。土壤质量综合评价显示,农林复合模式中大扁杏-花生-玉米对土壤的改良效果最好,大扁杏-麻黄草、樟子松-花生次之。在土层深度上,大扁杏-花生-玉米模式和大扁杏-麻黄草模式对0~20 cm土层的土壤改良效果好于20~40 cm ;樟子松-花生模式结果与之相反。

  12. Numerical simulation of microclimate in Beijing typical residential area based on ENVI-met model%基于ENVI-met的北京典型住宅区微气候数值模拟分析

    Institute of Scientific and Technical Information of China (English)

    秦文翠; 胡聃; 李元征; 郭振

    2015-01-01

    基于三维微气候模拟软件ENVI-met,以北京典型住宅区为研究对象,建立实况及设有屋顶绿化两种场景下的三维数值模拟模型,对研究区的微气候特征进行模拟分析。结果表明:微气候ENVI-met模型经过多次参数校正后,模型模拟结果与实测结果较接近,能较好反应微尺度气候的分布特征;屋顶经过简单的绿化后具有较好的降温增湿效果,使研究区平均温度降低了2—3℃,相对湿度增加了2.7%,风速由0.32—2.70 m·s-1降低至0.40—1.11 m·s-1,整体下降了0.34 m·s-1。ENVI-met通过三维模型可有效地应用于微气候模拟评价中,对评估当地微气候设计和城市规划具有一定的应用性。%Based on an ENVI-met three-dimensional microclimate model,a numerical simulation model in a typical residential area of Beijing under the actual situation and roof greening conditions was established and microclimate characteristics were simulated.The results show that the simulated value is similar to the observed one after multi-ple parameter calibration for the ENVI-met model,and the model could reflect the micro-scale climate distribution characteristics.Roof greening significantly decreases temperature and increases humidity.Mean temperature in the study area decreases by 2-3 ℃ after roof greening;relative humidity increases by 2 .7%;wind speed falls by 0.34 m·s-1 ,and its range decreases from 0.40-1 .1 1 m·s-1 to 0.32-2.70 m·s-1 .The ENVI-met model could be used in the microclimate simulation and assessment by an effective three-dimensional model,which could provide scientific information for the local microclimate design and urban planning.

  13. VARIABLE SELECTION BY PSEUDO WAVELETS IN HETEROSCEDASTIC REGRESSION MODELS INVOLVING TIME SERIES

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    A simple but efficient method has been proposed to select variables in heteroscedastic regression models. It is shown that the pseudo empirical wavelet coefficients corresponding to the significant explanatory variables in the regression models are clearly larger than those nonsignificant ones, on the basis of which a procedure is developed to select variables in regression models. The coefficients of the models are also estimated. All estimators are proved to be consistent.

  14. Psychometric Framework for Modeling Parental Involvement and Reading Literacy. IEA Research for Education

    Science.gov (United States)

    Punter, R. Annemiek; Glas, Cees A. W.; Meelissen, Martina R. M.

    2016-01-01

    Parental involvement is seen as one of the most malleable factors of the student's home situation, which makes it a relevant subject for schools, educational policies, and research. Though many studies have researched its role in student achievement, effects are not univocal. It is difficult to tell whether these inconsistent results are caused by…

  15. 南京地区典型居住建筑能耗模型及65%节能措施研究%Energy consumption model and 65% energy conservation measures for typical residential buildings in Nanjing

    Institute of Scientific and Technical Information of China (English)

    金斯科; 龚延风

    2011-01-01

    Calculates the annual energy amounts consumed by a typical residential building in intermittent operation mode with 24 different envelope property combinations in Nanjing by using DeST software and establishes the regression model of building energy consumption. Analyses the impact of thermal properties of enclosure and area ratio of window to wall on building energy consumption and proposes the 65% energy conservation measures for the residential buildings in this area.%采用DeST能耗软件模拟了南京一典型居住建筑在24种围护结构参数组合及间歇空调运行模式下的建筑全年能耗,并建立了南京地区典型居住建筑的能耗回归模型.同时分析了围护结构热工参数及窗墙面积比对建筑物能耗的影响,并提出了该地区居住建筑节能65%的措施.

  16. The Impact of Field Trips and Family Involvement on Mental Models of the Desert Environment

    Science.gov (United States)

    Judson, Eugene

    2011-07-01

    This study examined the mental models of the desert environment held by fourth- and seventh-grade students in the USA and whether those mental models could be affected by: (1) classroom field trips to a desert riparian preserve, and (2) interaction with family members at the same preserve. Results generally indicated that students in this study were resolute in their models and that field trips did not impact the types of models students adhered to. Twenty-three seventh-grade students who self-selected to participate in a Family Science Club with their parents did demonstrate a shift in their mental models and developed significantly more sophisticated models over time. A critical implication of the study is that unless transformation of mental models of the environment is an explicit goal of instruction, simple exposure to the environment (even within the context of life science instruction) will not transform understandings of how organisms within an environment act and interact interdependently.

  17. A Framework for Quantitative Modeling of Neural Circuits Involved in Sleep-to-Wake Transition

    Directory of Open Access Journals (Sweden)

    Siamak eSorooshyari

    2015-02-01

    Full Text Available Identifying the neuronal circuits and dynamics of sleep-to-wake transition is essential to understanding brain regulation of behavioral states, including sleep-wake cycles, arousal, and hyperarousal. Recent work by different laboratories has used optogenetics to determine the role of individual neuromodulators in state transitions. The optogenetically-driven data does not yet provide a multi-dimensional schematic of the mechanisms underlying changes in vigilance states. This work presents a modeling framework to interpret, assist, and drive research on the sleep-regulatory network. We identify feedback, redundancy, and gating hierarchy as three fundamental aspects of this model. The presented model is expected to expand as additional data on the contribution of each transmitter to a vigilance state becomes available. Incorporation of conductance-based models of neuronal ensembles into this model and existing models of cortical excitability will provide more comprehensive insight into sleep dynamics as well as sleep and arousal-related disorders.

  18. A Framework for Quantitative Modeling of Neural Circuits Involved in Sleep-to-Wake Transition

    Science.gov (United States)

    Sorooshyari, Siamak; Huerta, Ramón; de Lecea, Luis

    2015-01-01

    Identifying the neuronal circuits and dynamics of sleep-to-wake transition is essential to understanding brain regulation of behavioral states, including sleep–wake cycles, arousal, and hyperarousal. Recent work by different laboratories has used optogenetics to determine the role of individual neuromodulators in state transitions. The optogenetically driven data do not yet provide a multi-dimensional schematic of the mechanisms underlying changes in vigilance states. This work presents a modeling framework to interpret, assist, and drive research on the sleep-regulatory network. We identify feedback, redundancy, and gating hierarchy as three fundamental aspects of this model. The presented model is expected to expand as additional data on the contribution of each transmitter to a vigilance state becomes available. Incorporation of conductance-based models of neuronal ensembles into this model and existing models of cortical excitability will provide more comprehensive insight into sleep dynamics as well as sleep and arousal-related disorders. PMID:25767461

  19. Unique Solution of a Coupled Fractional Differential System Involving Integral Boundary Conditions from Economic Model

    Directory of Open Access Journals (Sweden)

    Rui Li

    2013-01-01

    Full Text Available We study the existence and uniqueness of the positive solution for the fractional differential system involving the Riemann-Stieltjes integral boundary conditions , , , , , and , where , , and and are the standard Riemann-Liouville derivatives, and are functions of bounded variation, and and denote the Riemann-Stieltjes integral. Our results are based on a generalized fixed point theorem for weakly contractive mappings in partially ordered sets.

  20. Modeling and Parameter Identification Involving 3-Hydroxypropionaldehyde Inhibitory Effects in Glycerol Continuous Fermentation

    Directory of Open Access Journals (Sweden)

    Zhaohua Gong

    2012-01-01

    Full Text Available Mathematical modeling and parameter estimation are critical steps in the optimization of biotechnological processes. In the 1,3-propanediol (1,3-PD production by glycerol fermentation process under anaerobic conditions, 3-hydroxypropionaldehyde (3-HPA accumulation would arouse an irreversible cessation of the fermentation process. Considering 3-HPA inhibitions to cells growth and to activities of enzymes, we propose a novel mathematical model to describe glycerol continuous cultures. Some properties of the above model are discussed. On the basis of the concentrations of extracellular substances, a parameter identification model is established to determine the kinetic parameters in the presented system. Through the penalty function technique combined with an extension of the state space method, an improved genetic algorithm is then constructed to solve the parameter identification model. An illustrative numerical example shows the appropriateness of the proposed model and the validity of optimization algorithm. Since it is difficult to measure the concentrations of intracellular substances, a quantitative robustness analysis method is given to infer whether the model is plausible for the intracellular substances. Numerical results show that the proposed model is of good robustness.

  1. Increasing Parental Involvement in the Primary Grades: The Magowan School Model.

    Science.gov (United States)

    Galen, Harlene

    Each school's version of a partnership with parents is unique, and no generic model exists. Designated in 1988 as one of 14 model schools in the New Jersey State Department of Education "Parents as Partners in Learning" project, the Mildred Magowan school in Edgewater Park has followed a systematic approach that has consistently led to…

  2. A Computational Model of a Descending Mechanosensory Pathway Involved in Active Tactile Sensing.

    Directory of Open Access Journals (Sweden)

    Jan M Ache

    2015-07-01

    Full Text Available Many animals, including humans, rely on active tactile sensing to explore the environment and negotiate obstacles, especially in the dark. Here, we model a descending neural pathway that mediates short-latency proprioceptive information from a tactile sensor on the head to thoracic neural networks. We studied the nocturnal stick insect Carausius morosus, a model organism for the study of adaptive locomotion, including tactually mediated reaching movements. Like mammals, insects need to move their tactile sensors for probing the environment. Cues about sensor position and motion are therefore crucial for the spatial localization of tactile contacts and the coordination of fast, adaptive motor responses. Our model explains how proprioceptive information about motion and position of the antennae, the main tactile sensors in insects, can be encoded by a single type of mechanosensory afferents. Moreover, it explains how this information is integrated and mediated to thoracic neural networks by a diverse population of descending interneurons (DINs. First, we quantified responses of a DIN population to changes in antennal position, motion and direction of movement. Using principal component (PC analysis, we find that only two PCs account for a large fraction of the variance in the DIN response properties. We call the two-dimensional space spanned by these PCs 'coding-space' because it captures essential features of the entire DIN population. Second, we model the mechanoreceptive input elements of this descending pathway, a population of proprioceptive mechanosensory hairs monitoring deflection of the antennal joints. Finally, we propose a computational framework that can model the response properties of all important DIN types, using the hair field model as its only input. This DIN model is validated by comparison of tuning characteristics, and by mapping the modelled neurons into the two-dimensional coding-space of the real DIN population. This

  3. A Computational Model of a Descending Mechanosensory Pathway Involved in Active Tactile Sensing.

    Science.gov (United States)

    Ache, Jan M; Dürr, Volker

    2015-07-01

    Many animals, including humans, rely on active tactile sensing to explore the environment and negotiate obstacles, especially in the dark. Here, we model a descending neural pathway that mediates short-latency proprioceptive information from a tactile sensor on the head to thoracic neural networks. We studied the nocturnal stick insect Carausius morosus, a model organism for the study of adaptive locomotion, including tactually mediated reaching movements. Like mammals, insects need to move their tactile sensors for probing the environment. Cues about sensor position and motion are therefore crucial for the spatial localization of tactile contacts and the coordination of fast, adaptive motor responses. Our model explains how proprioceptive information about motion and position of the antennae, the main tactile sensors in insects, can be encoded by a single type of mechanosensory afferents. Moreover, it explains how this information is integrated and mediated to thoracic neural networks by a diverse population of descending interneurons (DINs). First, we quantified responses of a DIN population to changes in antennal position, motion and direction of movement. Using principal component (PC) analysis, we find that only two PCs account for a large fraction of the variance in the DIN response properties. We call the two-dimensional space spanned by these PCs 'coding-space' because it captures essential features of the entire DIN population. Second, we model the mechanoreceptive input elements of this descending pathway, a population of proprioceptive mechanosensory hairs monitoring deflection of the antennal joints. Finally, we propose a computational framework that can model the response properties of all important DIN types, using the hair field model as its only input. This DIN model is validated by comparison of tuning characteristics, and by mapping the modelled neurons into the two-dimensional coding-space of the real DIN population. This reveals the versatility

  4. 基于水动力的典型矿山泥石流运动模式研究%Study on typical movement model in mine debris flow based on hydrodynamic force conditions

    Institute of Scientific and Technical Information of China (English)

    常鸣; 唐川

    2014-01-01

    “4·20”芦山地震导致人工堆积矿渣更加破碎,位于震区的石棉县后沟属于典型的矿山泥石流易发区,其泥石流运动模式与所在流域的地形条件、水文条件、物源条件密切相关。由于人为泥石流和自然泥石流在运动模式上存在差异,因此本文从地形、水文、静动力及物源4个条件入手,以石棉县后沟为例,详细论述矿山泥石流的运动模式。研究结果表明,后沟泥石流的运动过程模式包含了初期降雨降低废弃矿渣稳定性、持续降雨侵蚀矿渣坡面、雨水汇集形成洪流起动沟道矿渣、高含矿渣洪流裹挟运移起动泥石流、沿途侵蚀矿渣加强了泥石流规模等5个方面。%Some artificial accumulations of slag become more broken caused by“4·20”Lushan earthquake in 2013. Hougou is a typical mines debris flow susceptible region in earthquake zone of Shimian County. The motion pattern of its debris flow is closely related with terrain, hydrologic, static and dynamic, and material conditions. Since there are differences in motion patterns of man-made and natural debris flows, this study started with the four conditions and took Hougou debris flow as an example to discuss the mo⁃tion pattern of mine debris flow in detail. The results show that the process of Hougou debris flow involves the following five aspects:(a) stability of waste slag reduced by initial rainfall;(b) slag slope eroded by continuous rainfall;(c) channel slag moving stimulated by rainwater;(d) debris flow forming with high content of slag torrent,and (e) debris flow scale enhanced by slag erosion along the gully.

  5. Competitive growth model involving random deposition and random deposition with surface relaxation

    Energy Technology Data Exchange (ETDEWEB)

    Horowitz, Claudio M.; Monetti, Roberto A.; Albano, Ezequiel V.

    2001-06-01

    A deposition model that considers a mixture of random deposition with surface relaxation and a pure random deposition is proposed and studied. As the system evolves, random deposition with surface relaxation (pure random deposition) take place with probability p and (1{minus}p), respectively. The discrete (microscopic) approach to the model is studied by means of extensive numerical simulations, while continuous equations are used in order to investigate the mesoscopic properties of the model. A dynamic scaling ansatz for the interface width W(L,t,p) as a function of the lattice side L, the time t and p is formulated and tested. Three exponents, which can be linked to the standard growth exponent of random deposition with surface relaxation by means of a scaling relation, are identified. In the continuous limit, the model can be well described by means of a phenomenological stochastic growth equation with a p-dependent effective surface tension.

  6. Deformation analysis of polymers composites: rheological model involving time-based fractional derivative

    DEFF Research Database (Denmark)

    Zhou, H. W.; Yi, H. Y.; Mishnaevsky, Leon

    2016-01-01

    A modeling approach to time-dependent property of Glass Fiber Reinforced Polymers (GFRP) composites is of special interest for quantitative description of long-term behavior. An electronic creep machine is employed to investigate the time-dependent deformation of four specimens of dog......-bond-shaped GFRP composites at various stress level. A negative exponent function based on structural changes is introduced to describe the damage evolution of material properties in the process of creep test. Accordingly, a new creep constitutive equation, referred to fractional derivative Maxwell model...... by the fractional derivative Maxwell model proposed in the paper are in a good agreement with the experimental data. It is shown that the new creep constitutive model proposed in the paper needs few parameters to represent various time-dependent behaviors....

  7. A model of a fishery with fish stock involving delay equations.

    Science.gov (United States)

    Auger, P; Ducrot, Arnaud

    2009-12-13

    The aim of this paper is to provide a new mathematical model for a fishery by including a stock variable for the resource. This model takes the form of an infinite delay differential equation. It is mathematically studied and a bifurcation analysis of the steady states is fulfilled. Depending on the different parameters of the problem, we show that Hopf bifurcation may occur leading to oscillating behaviours of the system. The mathematical results are finally discussed.

  8. Deformation analysis of polymers composites: rheological model involving time-based fractional derivative

    Science.gov (United States)

    Zhou, H. W.; Yi, H. Y.; Mishnaevsky, L.; Wang, R.; Duan, Z. Q.; Chen, Q.

    2016-08-01

    A modeling approach to time-dependent property of Glass Fiber Reinforced Polymers (GFRP) composites is of special interest for quantitative description of long-term behavior. An electronic creep machine is employed to investigate the time-dependent deformation of four specimens of dog-bond-shaped GFRP composites at various stress level. A negative exponent function based on structural changes is introduced to describe the damage evolution of material properties in the process of creep test. Accordingly, a new creep constitutive equation, referred to fractional derivative Maxwell model, is suggested to characterize the time-dependent behavior of GFRP composites by replacing Newtonian dashpot with the Abel dashpot in the classical Maxwell model. The analytic solution for the fractional derivative Maxwell model is given and the relative parameters are determined. The results estimated by the fractional derivative Maxwell model proposed in the paper are in a good agreement with the experimental data. It is shown that the new creep constitutive model proposed in the paper needs few parameters to represent various time-dependent behaviors.

  9. Involvement of upregulation of miR-210 in a rat epilepsy model

    Science.gov (United States)

    Chen, Licheng; Zheng, Hao; Zhang, Shimeng

    2016-01-01

    Epilepsy is a common type of neurological disorder with complex etiology. The mechanisms are still not clear. MicroRNAs are endogenous noncoding RNAs with many physiological activities. Multiple microRNAs were abnormally expressed in status epilepticus, including miR-210. In this study, we applied lithium chloride and pilocarpine to induce epileptic activity and aimed to disclose the potential mechanisms. Our data showed that miR-210 was significantly upregulated in hippocampus one day after modeling (P<0.05 vs control) and the high expression of miR-210 lasted for at least 30 days. By contrast, γ-aminobutyric acid (GABA) level significantly decreased concurrently after modeling (P<0.05 vs control). To question whether miR-210 could be a potential therapeutic target for epilepsy, miR-210 inhibitor was administrated through intrahippocampal injection after epilepsy modeling. Our data showed that morphological changes of hippocampal neurons and apoptosis triggered by epilepsy were mitigated by miR-210 inhibition. More importantly, the expressions of GABA-related proteins, including GABAA receptor α1, glutamate decarboxylase, and GABA transporter 1, were significantly elevated after epilepsy modeling in both mRNA and protein levels 3 days postmodeling (P<0.05 vs control), which were mitigated by miR-210 inhibitor treatment (P<0.05 vs model). In addition, epilepsy-induced upregulation of GABA transaminase was alleviated by miR-210 inhibitor. Taken together, these data implicated potential roles of miR-210 in lithium chloride–pilocarpine-induced epilepsy model and miR-210 could serve as a potential therapeutic target in status epilepticus. PMID:27471387

  10. Two Scales, Hybrid Model for Soils, Involving Artificial Neural Network and Finite Element Procedure

    Directory of Open Access Journals (Sweden)

    Krasiński Marcin

    2015-02-01

    Full Text Available A hybrid ANN-FE solution is presented as a result of two level analysis of soils: a level of a laboratory sample and a level of engineering geotechnical problem. Engineering properties of soils (sands are represented directly in the form of ANN (this is in contrast with our former paper where ANN approximated constitutive relationships. Initially the ANN is trained with Duncan formula (Duncan and Chang [2], then it is re-trained (calibrated with some available experimental data, specific for the soil considered. The obtained approximation of the constitutive parameters is used directly in finite element method at the level of a single element at the scale of the laboratory sample to check the correct representation of the laboratory test. Then, the finite element that was successfully tested at the level of laboratory sample is used at the macro level to solve engineering problems involving the soil for which it was calibrated.

  11. An ODE for an Overloaded X Model Involving a Stochastic Averaging Principle

    OpenAIRE

    Ward Whitt; Ohad Perry

    2010-01-01

    We study an ordinary differential equation (ODE) arising as the many-server heavy-traffic fluid limit of a sequence of overloaded Markovian queueing models with two customer classes and two service pools. The system, known as the X model in the call-center literature, operates under the fixed-queue-ratio-with-thresholds (FQR-T) control, which we proposed in a recent paper as a way for one service system to help another in face of an unanticipated overload. Each pool serves only its own class ...

  12. Ethnic differences in the effect of parenting on gang involvement and gang delinquency: a longitudinal, hierarchical linear modeling perspective.

    Science.gov (United States)

    Walker-Barnes, C J; Mason, C A

    2001-01-01

    This study examined the relative influence of peer and parenting behavior on changes in adolescent gang involvement and gang-related delinquency. An ethnically diverse sample of 300 ninth-grade students was recruited and assessed on eight occasions during the school year. Analyses were conducted using hierarchical linear modeling. Results indicated that, in general, adolescents decreased their level of gang involvement over the course of the school year, whereas the average level of gang delinquency remained constant over time. As predicted, adolescent gang involvement and gang-related delinquency were most strongly predicted by peer gang involvement and peer gang delinquency, respectively. Nevertheless, parenting behavior continued to significantly predict change in both gang involvement and gang delinquency, even after controlling for peer behavior. A significant interaction between parenting and ethnic and cultural heritage found the effect of parenting to be particularly salient for Black students, for whom higher levels of behavioral control and lower levels of lax parental control were related to better behavioral outcomes over time, whereas higher levels of psychological control predicted worse behavioral outcomes.

  13. Radiation induced muscositis as space flight risk. Model studies on X-ray and heavy ion irradiated typical oral mucosa models; Strahlungsinduzierte Mukositis als Risiko der Raumfahrt. Modelluntersuchungen an Roentgen- und Schwerionen-bestrahlten organotypischen Mundschleimhaut-Modellen

    Energy Technology Data Exchange (ETDEWEB)

    Tschachojan, Viktoria

    2014-07-29

    Humans in exomagnetospheric space are exposed to highly energetic heavy ion radiation which can be hardly shielded. Since radiation-induced mucositis constitutes a severe complication of heavy ion radiotherapy, it would also implicate a serious medical safety risk for the crew members during prolonged space flights such as missions to Moon or Mars. For assessment of risk developing radiation-induced mucositis, three-dimensional organotypic cultures of immortalized human keratinocytes and fibroblasts were irradiated with a {sup 12}C particle beam at high energies or X-Rays. Immunofluorescence stainings were done from cryosections and radiation induced release of cytokines and chemokines was quantified by ELISA from culture supernatants. The major focuses of this study were on 4, 8, 24 and 48 hours after irradiation. The conducted analyses of our mucosa model showed many structural similarities with the native oral mucosa and authentic immunological responses to radiation exposure. Quantification of the DNA damage in irradiated mucosa models revealed about twice as many DSB after heavy-ion irradiation compared to X-rays at definite doses and time points, suggesting a higher gene toxicity of heavy ions. Nuclear factor κB activation was observed after treatment with X-rays or {sup 12}C particles. An activation of NF κB p65 in irradiated samples could not be detected. ELISA analyses showed significantly higher interleukin 6 and interleukin 8 levels after irradiation with X-rays and {sup 12}C particles compared to non-irradiated controls. However, only X-rays induced significantly higher levels of interleukin 1β. Analyses of TNF-α and IFN-γ showed no radiation-induced effects. Further analyses revealed a radiation-induced reduction in proliferation and loss of compactness in irradiated oral mucosa model, which would lead to local lesions in vivo. In this study we revealed that several pro-inflammatory markers and structural changes are induced by X-rays and heavy

  14. Data, analysis and modeling of physical properties for process designof systems involving lipids

    DEFF Research Database (Denmark)

    Cunico, Larissa; Ceriani, Roberta; Sarup, Bent

    2013-01-01

    Pure component and mixture properties are necessary for synthesis, design, and analysis of processes forthe production of edible oils, fats, biodiesel, and other lipids. The lack of measured data for these systemsmakes it necessary to develop reliable predictive models based on limited data. We...

  15. Model studies of volatile diesel exhaust particle formation: organic vapours involved in nucleation and growth?

    Science.gov (United States)

    Pirjola, L.; Karl, M.; Rönkkö, T.; Arnold, F.

    2015-02-01

    High concentration of volatile nucleation mode particles (NUP) formed in the atmosphere during exhaust cools and dilutes have hazardous health effects and impair visibility in urban areas. Nucleation mechanisms in diesel exhaust are only poorly understood. We performed model studies using two sectional aerosol dynamics process models AEROFOR and MAFOR on the formation of particles in the exhaust of a diesel engine, equipped with an oxidative after-treatment system and running with low fuel sulphur content (FSC), under laboratory sampling conditions where the dilution system mimics real-world conditions. Different nucleation mechanisms were tested; based on the measured gaseous sulphuric acid (GSA) and non-volatile core and soot particle number concentrations of the raw exhaust, the model simulations showed that the best agreement between model predictions and measurements in terms of particle number size distribution was obtained by barrierless heteromolecular homogeneous nucleation between GSA and semi-volatile organic vapour (for example adipic acid) combined with the homogeneous nucleation of GSA alone. Major growth of the particles was predicted to occur by the same organic vapour at concentrations of (1-2) ×1012cm-3. The pre-existing core and soot mode concentrations had opposite trend on the NUP formation, and maximum NUP formation was predicted if a diesel particle filter (DPF) was used. On the other hand, NUP formation was ceased if the GSA concentration was less than 1010cm-3 which suggests, based on the measurements, the usage of biofuel to prevent volatile particles in diesel exhaust.

  16. Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models

    Science.gov (United States)

    Liu, Huiping; Patel, Manishkumar R.; Prescher, Jennifer A.; Patsialou, Antonia; Qian, Dalong; Lin, Jiahui; Wen, Susanna; Chang, Ya-Fang; Bachmann, Michael H.; Shimono, Yohei; Dalerba, Piero; Adorno, Maddalena; Lobo, Neethan; Bueno, Janet; Dirbas, Frederick M.; Goswami, Sumanta; Somlo, George; Condeelis, John; Contag, Christopher H.; Gambhir, Sanjiv Sam; Clarke, Michael F.

    2010-01-01

    To examine the role of breast cancer stem cells (BCSCs) in metastasis, we generated human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled with optical reporter fusion genes. These models recapitulate human cancer features not captured with previous models, including spontaneous metastasis in particular, and provide a useful platform for studies of breast tumor initiation and progression. With noninvasive imaging approaches, as few as 10 cells of stably labeled BCSCs could be tracked in vivo, enabling studies of early tumor growth and spontaneous metastasis. These advances in BCSC imaging revealed that CD44+ cells from both primary tumors and lung metastases are highly enriched for tumor-initiating cells. Our metastatic cancer models, combined with noninvasive imaging techniques, constitute an integrated approach that could be applied to dissect the molecular mechanisms underlying the dissemination of metastatic CSCs (MCSCs) and to explore therapeutic strategies targeting MCSCs in general or to evaluate individual patient tumor cells and predict response to therapy. PMID:20921380

  17. The "Commitment Model" for Clinical Ethics Consultations: Society's Involvement in the Solution of Individual Cases.

    Science.gov (United States)

    Fournier, Véronique; Spranzi, Marta; Foureur, Nicolas; Brunet, Laurence

    2015-01-01

    Several approaches to clinical ethics consultation (CEC) exist in medical practice and are widely discussed in the clinical ethics literature; different models of CECs are classified according to their methods, goals, and consultant's attitude. Although the "facilitation" model has been endorsed by the American Society for Bioethics and Humanities (ASBH) and is described in an influential manual, alternative approaches, such as advocacy, moral expertise, mediation, and engagement are practiced and defended in the clinical ethics field. Our Clinical Ethics Center in Paris was founded in 2002 in the wake of the Patients' Rights Act, and to date it is the largest center that provides consultation services in France. In this article we shall describe and defend our own approach to clinical ethics consultation, which we call the "Commitment Model," in comparison with other existing models. Indeed commitment implies, among other meanings, continuity through time, a series of coherent actions, and the realization of important social goals. By drawing on a recent consultation case, we shall describe the main steps of our consultation procedure: interviews with major stakeholders, including patients and proxies; case conferences; and follow up. We shall show why we have chosen the term "commitment" to represent our approach at three different but interrelated levels: commitment towards patients, within the case conference group, and towards society as a whole.

  18. Submodels of model of nonlinear diffusion in the inhomogeneous medium involving absorption

    Energy Technology Data Exchange (ETDEWEB)

    Chirkunov, Yu. A., E-mail: chr101@mail.ru [Novosibirsk State Technical University, Marks Avenue 20, Novosibirsk 630073 (Russian Federation)

    2015-10-15

    We study the five-parameter model, describing the process of nonlinear diffusion in an inhomogeneous medium in the presence of absorption, for which the differential equation of the model admits a continuous Lie group of transformations, acting on the set of its solutions. We found six submodels of the original model of nonlinear diffusion, with different symmetry properties. Of these six submodels, the five submodels with transient absorption, for which the absorption coefficient depends on time according to a power law, represent the greatest interest with a mathematical point of view and with the point of view of physical applications. For each of these nonlinear submodels, we obtained formulas for producing new solutions that contain arbitrary constants, and we found all invariant submodels. All essentially distinct invariant solutions describing these invariant submodels are found in an explicit form or are reduced to finding the solution of nonlinear integral equations. The presence of the arbitrary constants in the integral equations that determine these solutions provide new opportunities for analytical and numerical study of boundary value problems for the received submodels and, thus, for the original model of nonlinear diffusion. For the received invariant submodels, we studied diffusion processes for which at the initial moment of the time at a fixed point is specified as a concentration and its gradient or as a concentration and its velocity. Solving of boundary value problems describing these processes is reduced to the solving of nonlinear integral equations. We established the existence and uniqueness of solutions of these boundary value problems under some additional conditions. The obtained results can be used to study the diffusion of substances, diffusion of conduction electrons and other particles, diffusion of physical fields and propagation of heat in inhomogeneous medium, and also to study a turbulence (Leith model, differential

  19. Model studies of volatile diesel exhaust particle formation: are organic vapours involved in nucleation and growth?

    Science.gov (United States)

    Pirjola, L.; Karl, M.; Rönkkö, T.; Arnold, F.

    2015-09-01

    A high concentration of volatile nucleation mode particles (NUP) formed in the atmosphere when the exhaust cools and dilutes has hazardous health effects and it impairs the visibility in urban areas. Nucleation mechanisms in diesel exhaust are only poorly understood. We performed model studies using two sectional aerosol dynamics process models AEROFOR and MAFOR on the formation of particles in the exhaust of a diesel engine, equipped with an oxidative after-treatment system and running with low fuel sulfur content (FSC) fuel, under laboratory sampling conditions where the dilution system mimics real-world conditions. Different nucleation mechanisms were tested. Based on the measured gaseous sulfuric acid (GSA) and non-volatile core and soot particle number concentrations of the raw exhaust, the model simulations showed that the best agreement between model predictions and measurements in terms of particle number size distribution was obtained by barrier-free heteromolecular homogeneous nucleation between the GSA and a semi-volatile organic vapour combined with the homogeneous nucleation of GSA alone. Major growth of the particles was predicted to occur due to the similar organic vapour at concentrations of (1-2) × 1012 cm-3. The pre-existing core and soot mode concentrations had an opposite trend on the NUP formation, and the maximum NUP formation was predicted if a diesel particle filter (DPF) was used. On the other hand, the model predicted that the NUP formation ceased if the GSA concentration in the raw exhaust was less than 1010 cm-3, which was the case when biofuel was used.

  20. SYNCHROTRON ORIGIN OF THE TYPICAL GRB BAND FUNCTION—A CASE STUDY OF GRB 130606B

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Bin-Bin; Briggs, Michael S. [Center for Space Plasma and Aeronomic Research (CSPAR), University of Alabama in Huntsville, Huntsville, AL 35899 (United States); Uhm, Z. Lucas; Zhang, Bing [Department of Physics and Astronomy, University of Nevada, Las Vegas, NV 89154 (United States); Connaughton, Valerie, E-mail: binbin.zhang@uah.edu [Science and Technology Institute, Universities Space Research Association, Huntsville, AL 35805 (United States)

    2016-01-10

    We perform a time-resolved spectral analysis of GRB 130606B within the framework of a fast-cooling synchrotron radiation model with magnetic field strength in the emission region decaying with time, as proposed by Uhm and Zhang. The data from all time intervals can be successfully fit by the model. The same data can be equally well fit by the empirical Band function with typical parameter values. Our results, which involve only minimal physical assumptions, offer one natural solution to the origin of the observed GRB spectra and imply that, at least some, if not all, Band-like GRB spectra with typical Band parameter values can indeed be explained by synchrotron radiation.

  1. The Remote Sensing Monitoring Model of the Typical Vegegtation Phenology in the Qinghai-Tibetan Plateau%青藏高原典型植被生长季遥感模型提取分析

    Institute of Scientific and Technical Information of China (English)

    常清; 王思远; 孙云晓; 殷慧; 尹航

    2014-01-01

    -series curve is defi-nitely suitable for the extraction of phenology paramethers. Then, we studied the extraction models of the typical vegetation phenology in the Qinghai-Tibetan Plteau with dynamic threshold value method, biggest change slope method and logistic curve fitting method. We compared and analyzed the monitoring results based on the nearly ten years NDVI dataset using the relationship between vegetation growing characteristics and daily mean temper-ature and then selected the dynamic threshold value method as the best model for typical vegetation phenology extraction in the Qinghai-Tibetan Plateau. Finally, we extracted the phenology information of grassland in the plateau with dynamic threshold value model. After the analysis of nearly ten years vegetation phenology, the re-sults showed that the alpine grassland in the plateau experienced the trend of start of season (SOS) advancing (the ratio is 0.248d/a) as the end of season (EOS) following a more complex rule. The andvanced SOS manily caused by the rise of spring temperature and the influence of precipation is not significant. What’s more, the veg-etation phenology and variation trends in the plateau showed obvious spatial distribution rule from the southeast to the northwest.

  2. Modelization of nanospace interaction involving a ferromagnetic atom: a spin polarization effect study by thermogravimetric analysis.

    Science.gov (United States)

    Santhanam, K S V; Chen, Xu; Gupta, S

    2014-04-01

    Ab initio studies of ferromagnetic atom interacting with carbon nanotubes have been reported in the literature that predict when the interaction is strong, a higher hybridization with confinement effect will result in spin polarization in the ferromagnetic atom. The spin polarization effect on the thermal oxidation to form its oxide is modeled here for the ferromagnetic atom and its alloy, as the above studies predict the 4s electrons are polarized in the atom. The four models developed here provide a pathway for distinguishing the type of interaction that exists in the real system. The extent of spin polarization in the ferromagnetic atom has been examined by varying the amount of carbon nanotubes in the composites in the thermogravimetric experiments. In this study we report the experimental results on the CoNi alloy which appears to show selective spin polarization. The products of the thermal oxidation has been analyzed by Fourier Transform Infrared Spectroscopy.

  3. Analysis of a Periodic Single Species Population Model Involving Constant Impulsive Perturbation

    Directory of Open Access Journals (Sweden)

    Ronghua Tan

    2014-01-01

    Full Text Available This is a continuation of the work of Tan et al. (2012. In this paper a periodic single species model controlled by constant impulsive perturbation is investigated. The constant impulse is realized at fixed moments of time. With the help of the comparison theorem of impulsive differential equations and Lyapunov functions, sufficient conditions for the permanence and global attractivity are established, respectively. Also, by comparing the above results with corresponding known results of Tan et al. (2012 (i.e., the above model with linear impulsive perturbations, we find that the two different types of impulsive perturbations have influence on the above dynamics. Numerical simulations are presented to substantiate our analytical results.

  4. The Undergraduate ALFALFA Team: A Model for Involving Undergraduates in Large Astronomy Collaborations

    Science.gov (United States)

    Craig, David W.; Koopmann, Rebecca A.; Haynes, Martha P.; Undergraduate ALFALFA Team, ALFALFA Team

    2016-01-01

    The NSF-sponsored Undergraduate ALFALFA (Arecibo Legacy Fast ALFA) Team (UAT) has allowed faculty and students from a wide range of public and private colleges and especially those with small astronomy programs to learn how science is accomplished in a large collaboration while contributing to the scientific goals of a legacy radio astronomy survey. This effort has been made possible through the collaboration of the ALFALFA PIs and graduate students, Arecibo Observatory staff, and the faculty at 19 undergraduate-focussed institutions. In this talk, we will discuss how the UAT model works for the ALFALFA project and lessons learned from our efforts over the 8 years of grant funding. We will provide suggestions on how the model could be applied to other legacy projects, particularly in such areas as online collaboration and software usage by undergraduates. This work has been supported by NSF grants AST-0724918/0902211, AST-075267/0903394, AST-0725380, and AST-1211005.

  5. Involvement of the Intrarenal Renin-Angiotensin System in Experimental Models of Glomerulonephritis

    Directory of Open Access Journals (Sweden)

    Maki Urushihara

    2012-01-01

    Full Text Available The intrarenal renin-angiotensin system (RAS has several pathophysiologic functions not only in blood pressure regulation but also in the development of glomerulonephritis (GN. Angiotensin II (Ang II is the biologically active product of the RAS. Locally produced Ang II induces inflammation, renal cell growth, mitogenesis, apoptosis, migration, and differentiation, regulates the gene expression of bioactive substances, and activates multiple intracellular signaling pathways, leading to tissue damage. Activation of the Ang II type 1 (AT1 receptor pathway results in the production of proinflammatory mediators, cell proliferation, and extracellular matrix synthesis, which facilitates glomerular injury. Previous studies have shown that angiotensin-converting enzyme inhibitors and/or AT1 receptor blockers have beneficial effects in experimental GN models and humans with various types of GN, and that these effects are more significant than their suppressive effects on blood pressure. In this paper, we focus on intrarenal RAS activation in the pathophysiology of experimental models of GN.

  6. Inventory Model for Deteriorating Items Involving Fuzzy with Shortages and Exponential Demand

    Directory of Open Access Journals (Sweden)

    Sharmila Vijai Stanly

    2015-11-01

    Full Text Available This paper considers the fuzzy inventory model for deteriorating items for power demand under fully backlogged conditions. We define various factors which are affecting the inventory cost by using the shortage costs. An intention of this paper is to study the inventory modelling through fuzzy environment. Inventory parameters, such as holding cost, shortage cost, purchasing cost and deterioration cost are assumed to be the trapezoidal fuzzy numbers. In addition, an efficient algorithm is developed to determine the optimal policy, and the computational effort and time are small for the proposed algorithm. It is simple to implement, and our approach is illustrated through some numerical examples to demonstrate the application and the performance of the proposed methodology.

  7. Switching model with two habitats and a predator involving group defence

    CERN Document Server

    Khan, Qamar J A; Jaju, R P

    2015-01-01

    Switching model with one predator and two prey species is considered. The prey species have the ability of group defence. Therefore, the predator will be attracted towards that habitat where prey are less in number. The stability analysis is carried out for two equilibrium values. The theoretical results are compared with the numerical results for a set of values. The Hopf bifuracation analysis is done to support the stability results.

  8. A metabolic model for members of the genus Tetrasphaera involved in enhanced biological phosphorus removal.

    Science.gov (United States)

    Kristiansen, Rikke; Nguyen, Hien Thi Thu; Saunders, Aaron Marc; Nielsen, Jeppe Lund; Wimmer, Reinhard; Le, Vang Quy; McIlroy, Simon Jon; Petrovski, Steve; Seviour, Robert J; Calteau, Alexandra; Nielsen, Kåre Lehmann; Nielsen, Per Halkjær

    2013-03-01

    Members of the genus Tetrasphaera are considered to be putative polyphosphate accumulating organisms (PAOs) in enhanced biological phosphorus removal (EBPR) from wastewater. Although abundant in Danish full-scale wastewater EBPR plants, how similar their ecophysiology is to 'Candidatus Accumulibacter phosphatis' is unclear, although they may occupy different ecological niches in EBPR communities. The genomes of four Tetrasphaera isolates (T. australiensis, T. japonica, T. elongata and T. jenkinsii) were sequenced and annotated, and the data used to construct metabolic models. These models incorporate central aspects of carbon and phosphorus metabolism critical to understanding their behavior under the alternating anaerobic/aerobic conditions encountered in EBPR systems. Key features of these metabolic pathways were investigated in pure cultures, although poor growth limited their analyses to T. japonica and T. elongata. Based on the models, we propose that under anaerobic conditions the Tetrasphaera-related PAOs take up glucose and ferment this to succinate and other components. They also synthesize glycogen as a storage polymer, using energy generated from the degradation of stored polyphosphate and substrate fermentation. During the aerobic phase, the stored glycogen is catabolized to provide energy for growth and to replenish the intracellular polyphosphate reserves needed for subsequent anaerobic metabolism. They are also able to denitrify. This physiology is markedly different to that displayed by 'Candidatus Accumulibacter phosphatis', and reveals Tetrasphaera populations to be unusual and physiologically versatile PAOs carrying out denitrification, fermentation and polyphosphate accumulation.

  9. Collaborative modelling for active involvement of stakeholders in urban flood risk management

    Directory of Open Access Journals (Sweden)

    M. Evers

    2012-09-01

    Full Text Available This paper presents an approach to enhance the role of local stakeholders in dealing with urban floods. The concept is based on the DIANE-CM project (Decentralised Integrated Analysis and Enhancement of Awareness through Collaborative Modelling and Management of Flood Risk of the 2nd ERANET CRUE funding initiative. The main objective of the project was to develop and test an advanced methodology for enhancing the resilience of local communities to flooding. Through collaborative modelling, a social learning process was initiated that enhances the social capacity of the stakeholders due to the interaction process. The other aim of the project was to better understand how data from hazard and vulnerability analyses and improved maps, as well as from the near real-time flood prediction, can be used to initiate a public dialogue (i.e. collaborative mapping and planning activities in order to carry out more informed and shared decision-making processes and to enhance flood risk awareness. The concept of collaborative modelling was applied in two case studies: (1 the Cranbrook catchment in the UK, with focus on pluvial flooding; and (2 the Alster catchment in Germany, with focus on fluvial flooding. As a result of the interactive and social learning process, supported by sociotechnical instruments, an understanding of flood risk was developed amongst the stakeholders and alternatives for flood risk management for the respective case study area were jointly developed and ranked as a basis for further planning and management.

  10. Involvement of Nitric Oxide in a Rat Model of Carrageenin-Induced Pleurisy

    Directory of Open Access Journals (Sweden)

    Masahiro Iwata

    2010-01-01

    Full Text Available Some evidence indicates that nitric oxide (NO contributes to inflammation, while other evidence supports the opposite conclusion. To clarify the role of NO in inflammation, we studied carrageenin-induced pleurisy in rats treated with an NO donor (NOC-18, a substrate for NO formation (L-arginine, and/or an NO synthase inhibitor (S-(2-aminoethyl isothiourea or NG-nitro-L-arginine. We assessed inflammatory cell migration, nitrite/nitrate values, lipid peroxidation and pro-inflammatory mediators. NOC-18 and L-arginine reduced the migration of inflammatory cells and edema, lowered oxidative stress, and normalized antioxidant enzyme activities. NO synthase inhibitors increased the exudate formation and inflammatory cell number, contributed to oxidative stress, induced an oxidant/antioxidant imbalance by maintaining high O−2, and enhanced the production of pro-inflammatory mediators. L-arginine and NOC-18 reversed the proinflammatory effects of NO synthase inhibitors, perhaps by reducing the expression of adhesion molecules on endothelial cells. Thus, our results indicate that NO is involved in blunting—not enhancing—the inflammatory response.

  11. A Hybrid Artificial Reputation Model Involving Interaction Trust, Witness Information and the Trust Model to Calculate the Trust Value of Service Providers

    Directory of Open Access Journals (Sweden)

    Gurdeep Singh Ransi

    2014-02-01

    Full Text Available Agent interaction in a community, such as the online buyer-seller scenario, is often uncertain, as when an agent comes in contact with other agents they initially know nothing about each other. Currently, many reputation models are developed that help service consumers select better service providers. Reputation models also help agents to make a decision on who they should trust and transact with in the future. These reputation models are either built on interaction trust that involves direct experience as a source of information or they are built upon witness information also known as word-of-mouth that involves the reports provided by others. Neither the interaction trust nor the witness information models alone succeed in such uncertain interactions. In this paper we propose a hybrid reputation model involving both interaction trust and witness information to address the shortcomings of existing reputation models when taken separately. A sample simulation is built to setup buyer-seller services and uncertain interactions. Experiments reveal that the hybrid approach leads to better selection of trustworthy agents where consumers select more reputable service providers, eventually helping consumers obtain more gains. Furthermore, the trust model developed is used in calculating trust values of service providers.

  12. Spectra of conditionalization and typicality in the multiverse

    Science.gov (United States)

    Azhar, Feraz

    2016-02-01

    An approach to testing theories describing a multiverse, that has gained interest of late, involves comparing theory-generated probability distributions over observables with their experimentally measured values. It is likely that such distributions, were we indeed able to calculate them unambiguously, will assign low probabilities to any such experimental measurements. An alternative to thereby rejecting these theories, is to conditionalize the distributions involved by restricting attention to domains of the multiverse in which we might arise. In order to elicit a crisp prediction, however, one needs to make a further assumption about how typical we are of the chosen domains. In this paper, we investigate interactions between the spectra of available assumptions regarding both conditionalization and typicality, and draw out the effects of these interactions in a concrete setting; namely, on predictions of the total number of species that contribute significantly to dark matter. In particular, for each conditionalization scheme studied, we analyze how correlations between densities of different dark matter species affect the prediction, and explicate the effects of assumptions regarding typicality. We find that the effects of correlations can depend on the conditionalization scheme, and that in each case atypicality can significantly change the prediction. In doing so, we demonstrate the existence of overlaps in the predictions of different "frameworks" consisting of conjunctions of theory, conditionalization scheme and typicality assumption. This conclusion highlights the acute challenges involved in using such tests to identify a preferred framework that aims to describe our observational situation in a multiverse.

  13. The intervention model for affective involvement and its effectiveness: Fostering affective involvement between persons who are congenitally deafblind and their communication partners

    NARCIS (Netherlands)

    Martens, M.A.W.

    2014-01-01

    Can one share emotions with someone who can’t hear and see well? This dissertation addresses the effectiveness of a training for professionals to foster affective involvement or the mutual sharing of emotions with people who are congenitally deafblind. People with congenital deafblindness are

  14. Typicality, physiological activity and concept identification.

    NARCIS (Netherlands)

    Das-Smaal, E.A.; Swart, de J.H.

    1981-01-01

    The extent to which instances are good or poor examples of their categories (typicality) was varied in a concept identification (CI) task. Typicality was first established for the kind of artificial material traditionally used in CI tasks (experiment 1). This material was employed in a CI task

  15. Service Innovation Involved by Employees and Customers:From Conceptual Model to an IT Service Case

    Institute of Scientific and Technical Information of China (English)

    LIU De-wen; LU Ruo-yu

    2006-01-01

    With the service industry and information technology developing, Service innovation occurs continually in business today. It is important for service firms to understand the service's business and process;customer knowledge including needs, expectations and experiences.However, employees are key factor to collect the customer's advice. At the same time, employees may organize customers for the new service. So, the integration of employees and customers will help service firm in the way of developing a new service and upgrading a service. The paper describes some models to explain the relation based on some literatures and give some advices for service firms. At last, we introduce an IT service case

  16. Three Aspects of Typicality in Multiverse Cosmology

    CERN Document Server

    Azhar, Feraz

    2016-01-01

    Extracting predictions from cosmological theories that describe a multiverse, for what we are likely to observe in our domain, is crucial to establishing the validity of these theories. One way to extract such predictions is from theory-generated probability distributions that allow for selection effects---generally expressed in terms of assumptions about anthropic conditionalization and how typical we are. In this paper, I urge three lessons about typicality in multiverse settings. (i) Because it is difficult to characterize our observational situation in the multiverse, we cannot assume that we are typical (as in the 'principle of mediocrity'): nor can we ignore the issue of typicality, for it has a measurable impact on predictions for our observations. (ii) There are spectra of assumptions about both conditionalization and typicality, which lead to coincident predictions for our observations, leading to problems of confirmation in multiverse cosmology. And moreover, (iii) when one has the freedom to consid...

  17. Biomembrane models and drug-biomembrane interaction studies: Involvement in drug design and development

    Directory of Open Access Journals (Sweden)

    R Pignatello

    2011-01-01

    Full Text Available Contact with many different biological membranes goes along the destiny of a drug after its systemic administration. From the circulating macrophage cells to the vessel endothelium, to more complex absorption barriers, the interaction of a biomolecule with these membranes largely affects its rate and time of biodistribution in the body and at the target sites. Therefore, investigating the phenomena occurring on the cell membranes, as well as their different interaction with drugs in the physiological or pathological conditions, is important to exploit the molecular basis of many diseases and to identify new potential therapeutic strategies. Of course, the complexity of the structure and functions of biological and cell membranes, has pushed researchers toward the proposition and validation of simpler two- and three-dimensional membrane models, whose utility and drawbacks will be discussed. This review also describes the analytical methods used to look at the interactions among bioactive compounds with biological membrane models, with a particular accent on the calorimetric techniques. These studies can be considered as a powerful tool for medicinal chemistry and pharmaceutical technology, in the steps of designing new drugs and optimizing the activity and safety profile of compounds already used in the therapy.

  18. Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine.

    Science.gov (United States)

    Freitas, R M

    2009-10-25

    The relationship between free radical and scavenger enzymes has been found in the epileptic phenomena and reactive oxygen species have been implicated in seizure-induced neurodegeneration. Using the epilepsy model obtained by systemic administration of pilocarpine in rats, we investigated the lipid peroxidation, nitrite content, superoxide dismutase (SOD) and catalase activities in the hippocampus of rats during chronic period. The enzyme activities as well as the lipid peroxidation and nitrite concentrations were measured using spectrophotometric methods and the results compared to values obtained from saline-treated animals. The superoxide dismutase and catalase activities increased during the chronic phase. In addition, lipid peroxidation and nitrite levels increased in same period in the hippocampus of animals observed during spontaneous recurrent seizures. Previous studies showed that animals presenting seizures and submitted to 24h of status epilepticus showed normal levels of superoxide dismutase and increased in catalase activities as well as an increase in hippocampal lipid peroxidation and nitrite concentrations. These results show a direct evidence of lipid peroxidation and nitrite during seizure activity that could be responsible for neuronal damage in the hippocampus of rats, during the establishment of pilocarpine model of epilepsy.

  19. An ODE for an Overloaded X Model Involving a Stochastic Averaging Principle

    CERN Document Server

    Perry, Ohad

    2010-01-01

    We study an ordinary differential equation (ODE) arising as the many-server heavy-traffic fluid limit of a sequence of overloaded Markovian queueing models with two customer classes and two service pools. The system, known as the X model in the call-center literature, operates under the fixed-queue-ratio-with-thresholds (FQR-T) control, which we proposed in a recent paper as a way for one service system to help another in face of an unanticipated overload. Each pool serves only its own class until a threshold is exceeded; then one-way sharing is activated with all customer-server assignments then driving the two queues toward a fixed ratio. For large systems, that fixed ratio is achieved approximately. The ODE describes system performance during an overload. The control is driven by a queue-difference stochastic process, which operates in a faster time scale than the queueing processes themselves, thus achieving a time-dependent steady state instantaneously in the limit. As a result, for the ODE, the driving ...

  20. Framing patient consent for student involvement in pelvic examination: a dual model of autonomy.

    Science.gov (United States)

    Carson-Stevens, Andrew; Davies, Myfanwy M; Jones, Rhiain; Chik, Aiman D Pawan; Robbé, Iain J; Fiander, Alison N

    2013-11-01

    Patient consent has been formulated in terms of radical individualism rather than shared benefits. Medical education relies on the provision of patient consent to provide medical students with the training and experience to become competent doctors. Pelvic examination represents an extreme case in which patients may legitimately seek to avoid contact with inexperienced medical students particularly where these are male. However, using this extreme case, this paper will examine practices of framing and obtaining consent as perceived by medical students. This paper reports findings of an exploratory qualitative study of medical students and junior doctors. Participants described a number of barriers to obtaining informed consent. These related to misunderstandings concerning student roles and experiences and insufficient information on the nature of the examination. Participants reported perceptions of the negative framing of decisions on consent by nursing staff where the student was male. Potentially coercive practices of framing of the decision by senior doctors were also reported. Participants outlined strategies they adopted to circumvent patients' reasons for refusal. Practices of framing the information used by students, nurses and senior doctors to enable patients to decide about consent are discussed in the context of good ethical practice. In the absence of a clear ethical model, coercion appears likely. We argue for an expanded model of autonomy in which the potential tension between respecting patients' autonomy and ensuring the societal benefit of well-trained doctors is recognised. Practical recommendations are made concerning information provision and clear delineations of student and patient roles and expectations.

  1. The necessary burden of involving stakeholders in agent-based modelling for education and decision-making

    Science.gov (United States)

    Bommel, P.; Bautista Solís, P.; Leclerc, G.

    2016-12-01

    We implemented a participatory process with water stakeholders for improving resilience to drought at watershed scale, and for reducing water pollution disputes in drought prone Northwestern Costa Rica. The purpose is to facilitate co-management in a rural watershed impacted by recurrent droughts related to ENSO. The process involved designing "ContaMiCuenca", a hybrid agent-based model where users can specify the decisions of their agents. We followed a Companion Modeling approach (www.commod.org) and organized 10 workshops that included research techniques such as participatory diagnostics, actor-resources-interaction and UML diagrams, multi-agents model design, and interactive simulation sessions. We collectively assessed the main water issues in the watershed, prioritized their importance, defined the objectives of the process, and pilot-tested ContaMiCuenca for environmental education with adults and children. Simulation sessions resulted in debates about the need to improve the model accuracy, arguably more relevant for decision-making. This helped identify sensible knowledge gaps in the groundwater pollution and aquifer dynamics that need to be addressed in order to improve our collective learning. Significant mismatches among participants expectations, objectives, and agendas considerably slowed down the participatory process. The main issue may originate in participants expecting technical solutions from a positivist science, as constantly promoted in the region by dole-out initiatives, which is incompatible with the constructivist stance of participatory modellers. This requires much closer interaction of community members with modellers, which may be hard to attain in the current research practice and institutional context. Nevertheless, overcoming these constraints is necessary for a true involvement of water stakeholders to achieve community-based decisions that facilitate integrated water management. Our findings provide significant guidance for

  2. Students' learning as the focus for shared involvement between universities and clinical practice: a didactic model for postgraduate degree projects.

    Science.gov (United States)

    Öhlén, J; Berg, L; Björk Brämberg, E; Engström, Å; German Millberg, L; Höglund, I; Jacobsson, C; Lepp, M; Lidén, E; Lindström, I; Petzäll, K; Söderberg, S; Wijk, H

    2012-10-01

    In an academic programme, completion of a postgraduate degree project could be a significant means of promoting student learning in evidence- and experience-based practice. In specialist nursing education, which through the European Bologna process would be raised to the master's level, there is no tradition of including a postgraduate degree project. The aim was to develop a didactic model for specialist nursing students' postgraduate degree projects within the second cycle of higher education (master's level) and with a specific focus on nurturing shared involvement between universities and healthcare settings. This study embodies a participatory action research and theory-generating design founded on empirically practical try-outs. The 3-year project included five Swedish universities and related healthcare settings. A series of activities was performed and a number of data sources secured. Constant comparative analysis was applied. A didactic model is proposed for postgraduate degree projects in specialist nursing education aimed at nurturing shared involvement between universities and healthcare settings. The focus of the model is student learning in order to prepare the students for participation as specialist nurses in clinical knowledge development. The model is developed for the specialist nursing education, but it is general and could be applicable to various education programmes.

  3. Modeling of glycerol-3-phosphate transporter suggests a potential 'tilt' mechanism involved in its function.

    Science.gov (United States)

    Tsigelny, Igor F; Greenberg, Jerry; Kouznetsova, Valentina; Nigam, Sanjay K

    2008-10-01

    Many major facilitator superfamily (MFS) transporters have similar 12-transmembrane alpha-helical topologies with two six-helix halves connected by a long loop. In humans, these transporters participate in key physiological processes and are also, as in the case of members of the organic anion transporter (OAT) family, of pharmaceutical interest. Recently, crystal structures of two bacterial representatives of the MFS family--the glycerol-3-phosphate transporter (GlpT) and lac-permease (LacY)--have been solved and, because of assumptions regarding the high structural conservation of this family, there is hope that the results can be applied to mammalian transporters as well. Based on crystallography, it has been suggested that a major conformational "switching" mechanism accounts for ligand transport by MFS proteins. This conformational switch would then allow periodic changes in the overall transporter configuration, resulting in its cyclic opening to the periplasm or cytoplasm. Following this lead, we have modeled a possible "switch" mechanism in GlpT, using the concept of rotation of protein domains as in the DynDom program17 and membranephilic constraints predicted by the MAPAS program.(23) We found that the minima of energies of intersubunit interactions support two alternate positions consistent with their transport properties. Thus, for GlpT, a "tilt" of 9 degrees -10 degrees rotation had the most favorable energetics of electrostatic interaction between the two halves of the transporter; moreover, this confirmation was sufficient to suggest transport of the ligand across the membrane. We conducted steered molecular dynamics simulations of the GlpT-ligand system to explore how glycerol-3-phosphate would be handled by the "tilted" structure, and obtained results generally consistent with experimental mutagenesis data. While biochemical data remain most consistent with a single-site alternating access model, our results raise the possibility that, while the

  4. COMPUTATIONAL MODELING AND DRUG DESIGNING OF LIPOPROTEIN LIPASE (LPL INVOLVED IN ISCHEMIC STROKE

    Directory of Open Access Journals (Sweden)

    Maryam Torabizadeh

    2012-12-01

    Full Text Available Homology modeling and flexible docking of Lipoprotein Lipase has been studied in silico approach. Blast result was found to have similarity with Lipoprotein Lipase of 83% identity with 1LPA. Active site of LPL protein was identified by CASTP. Large potential drugs were designed for identifying molecules that can likely bind to protein target of interest. The different drug derivatives designed were used for docking with the generated structure, among the 10 derivatives designed, 3rd derivative showed highest docking result. The drug derivatives were docked to the protein by hydrogen bonding interactions and these interactions play an important role in the binding studies. Our investigations may be helpful for further studies.

  5. Circadian abnormalities in mouse models of Smith-Magenis syndrome: evidence for involvement of RAI1.

    Science.gov (United States)

    Lacaria, Melanie; Gu, Wenli; Lupski, James R

    2013-07-01

    Smith-Magenis syndrome (SMS; OMIM 182290) is a genomic disorder characterized by multiple congenital anomalies, intellectual disability, behavioral abnormalities, and disordered sleep resulting from an ~3.7 Mb deletion copy number variant (CNV) on chromosome 17p11.2 or from point mutations in the gene RAI1. The reciprocal duplication of this region results in another genomic disorder, Potocki-Lupski syndrome (PTLS; OMIM 610883), characterized by autism, intellectual disability, and congenital anomalies. We previously used chromosome-engineering and gene targeting to generate mouse models for PTLS (Dp(11)17/+), and SMS due to either deletion CNV or gene knock-out (Df(11)17-2/+ and Rai1(+/-) , respectively) and we observed phenotypes in these mouse models consistent with their associated human syndromes. To investigate the contribution of individual genes to the circadian phenotypes observed in SMS, we now report the analysis of free-running period lengths in Rai1(+/-) and Df(11)17-2/+ mice, as well as in mice deficient for another known circadian gene mapping within the commonly deleted/duplicated region, Dexras1, and we compare these results to those previously observed in Dp(11)17/+ mice. Reduced free-running period lengths were seen in Df(11)17-2/+, Rai1(+/-) , and Dexras1(-/-) , but not Dexras1(+/-) mice, suggesting that Rai1 may be the primary gene underlying the circadian defects in SMS. However, we cannot rule out the possibility that cis effects between multiple haploinsufficient genes in the SMS critical interval (e.g., RAI1 and DEXRAS1) either exacerbate the circadian phenotypes observed in SMS patients with deletions or increase their penetrance in certain environments. This study also confirms a previous report of abnormal circadian function in Dexras1(-/-) mice.

  6. microRNAs Involved in Regulating Spontaneous Recovery in Embolic Stroke Model.

    Directory of Open Access Journals (Sweden)

    Fu Jia Liu

    Full Text Available To date, miRNA expression studies on cerebral ischemia in both human and animal models have focused mainly on acute phase of ischemic stroke. In this study, we present the roles played by microRNAs in the spontaneous recovery phases in cerebral ischemia using rodent stroke models. Brain tissues were harvested at different reperfusion time points ranging from 0-168 hrs after middle cerebral artery occlusion using homologous emboli. MiRNA and mRNA expression profiles were investigated by microarray followed by multiple statistical analysis. Candidate transcripts were also validated by quantitative RT-PCR. Three specific groups of miRNAs were observed among a total of 346 differentially expressed miRNAs. miRNAs, miR-21, -142-3p, -142-5p, and -146a displayed significant upregulation during stroke recovery (48 hrs to 168 hrs compared with those during acute phases (0 hrs to 24 hrs. On the other hand, an opposite trend was observed in the expression of miR-196a/b/c, -224 and -324-3p. Interestingly, miR-206, -290, -291a-5p and -30c-1*, positively correlated with the infarct sizes, with an initial increase up to 24hrs followed by a gradual decrease from 48 hrs to 168 hrs (R = 0.95. Taken together with the expression levels of corresponding mRNA targets, we have also found that Hedgehog, Notch, Wnt and TGF-β signaling pathways could play significant roles in stroke recovery and especially in neuronal repair.

  7. Involvement of innate and adaptive immunity in a murine model of coronary arteritis mimicking Kawasaki disease.

    Science.gov (United States)

    Schulte, Danica J; Yilmaz, Atilla; Shimada, Kenichi; Fishbein, Michael C; Lowe, Emily L; Chen, Shuang; Wong, Michelle; Doherty, Terence M; Lehman, Thomas; Crother, Timothy R; Sorrentino, Rosalinda; Arditi, Moshe

    2009-10-15

    Kawasaki disease (KD) is the most common cause of acquired cardiac disease and acute vasculitis in children in the developed world. Injection of a cell wall extract isolated from Lactobacillus casei (LCCWE) into mice causes a focal coronary arteritis that histopathologically mimics the coronary lesions observed in KD patients. In this study we used this model to investigate the participation of T cells, B cells, and dendritic cells (DC) in the development of coronary arteritis. RAG1(-/-), B cell(null), and wild-type (WT) mice were injected with a single dose of LCCWE (500 microg/mouse i.p.). None of the RAG1(-/-) mice developed coronary arteritis, whereas 70% of WT and 100% of B cell(null) mice developed coronary lesions, indicating that T cells were required for lesion formation. When splenocytes isolated from LCCWE-treated mice were restimulated with LCCWE, we observed significant IFN-gamma secretion in WT but not in RAG1(-/-) mice. Immunohistochemical staining showed F4/80(+) macrophages, activated MIDC-8(+) myeloid DCs (mDC), plasmacytoid DCs, and colocalization of CD3(+) T cells with mDCs in coronary artery lesions, suggesting an Ag-driven process. T cells but not B cells are required for LCCWE-induced coronary arteritis. Similar to human lesions, the coronary lesions contain macrophages, activated mDCs, and plaslmacytoid DCs all in close proximity to T cells, further strengthening the relevance of this mouse model to the immunopathology of coronary disease in KD. These studies are consistent with the interpretation that macrophages and DCs may collaborate with T cells in the pathological mechanisms of coronary arteritis.

  8. How to develop, validate, and compare clinical prediction models involving radiological parameters: Study design and statistical methods

    Energy Technology Data Exchange (ETDEWEB)

    Han, Kyung Hwa; Choi, Byoung Wook [Dept. of Radiology, and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul (Korea, Republic of); Song, Ki Jun [Dept. of Biostatistics and Medical Informatics, Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2016-06-15

    Clinical prediction models are developed to calculate estimates of the probability of the presence/occurrence or future course of a particular prognostic or diagnostic outcome from multiple clinical or non-clinical parameters. Radiologic imaging techniques are being developed for accurate detection and early diagnosis of disease, which will eventually affect patient outcomes. Hence, results obtained by radiological means, especially diagnostic imaging, are frequently incorporated into a clinical prediction model as important predictive parameters, and the performance of the prediction model may improve in both diagnostic and prognostic settings. This article explains in a conceptual manner the overall process of developing and validating a clinical prediction model involving radiological parameters in relation to the study design and statistical methods. Collection of a raw dataset; selection of an appropriate statistical model; predictor selection; evaluation of model performance using a calibration plot, Hosmer-Lemeshow test and c-index; internal and external validation; comparison of different models using c-index, net reclassification improvement, and integrated discrimination improvement; and a method to create an easy-to-use prediction score system will be addressed. This article may serve as a practical methodological reference for clinical researchers.

  9. Networks involved in olfaction and their dynamics using independent component analysis and unified structural equation modeling.

    Science.gov (United States)

    Karunanayaka, Prasanna; Eslinger, Paul J; Wang, Jian-Li; Weitekamp, Christopher W; Molitoris, Sarah; Gates, Kathleen M; Molenaar, Peter C M; Yang, Qing X

    2014-05-01

    The study of human olfaction is complicated by the myriad of processing demands in conscious perceptual and emotional experiences of odors. Combining functional magnetic resonance imaging with convergent multivariate network analyses, we examined the spatiotemporal behavior of olfactory-generated blood-oxygenated-level-dependent signal in healthy adults. The experimental functional magnetic resonance imaging (fMRI) paradigm was found to offset the limitations of olfactory habituation effects and permitted the identification of five functional networks. Analysis delineated separable neuronal circuits that were spatially centered in the primary olfactory cortex, striatum, dorsolateral prefrontal cortex, rostral prefrontal cortex/anterior cingulate, and parietal-occipital junction. We hypothesize that these functional networks subserve primary perceptual, affective/motivational, and higher order olfactory-related cognitive processes. Results provided direct evidence for the existence of parallel networks with top-down modulation for olfactory processing and clearly distinguished brain activations that were sniffing-related versus odor-related. A comprehensive neurocognitive model for olfaction is presented that may be applied to broader translational studies of olfactory function, aging, and neurological disease.

  10. Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems.

    Science.gov (United States)

    Siwaszek, Aleksandra; Ukleja, Marta; Dziembowski, Andrzej

    2014-01-01

    The process of mRNA decay and surveillance is considered to be one of the main posttranscriptional gene expression regulation platforms in eukaryotes. The degradation of stable, protein-coding transcripts is normally initiated by removal of the poly(A) tail followed by 5'-cap hydrolysis and degradation of the remaining mRNA body by Xrn1. Alternatively, the exosome complex degrades mRNA in the 3'>5'direction. The newly discovered uridinylation-dependent pathway, which is present in many different organisms, also seems to play a role in bulk mRNA degradation. Simultaneously, to avoid the synthesis of incorrect proteins, special cellular machinery is responsible for the removal of faulty transcripts via nonsense-mediated, no-go, non-stop or non-functional 18S rRNA decay. This review is focused on the major eukaryotic cytoplasmic mRNA degradation pathways showing many similarities and pointing out main differences between the main model-species: yeast, Drosophila, plants and mammals.

  11. The Leech Nervous System: A Valuable Model to Study the Microglia Involvement in Regenerative Processes

    Directory of Open Access Journals (Sweden)

    Françoise Le Marrec-Croq

    2013-01-01

    Full Text Available Microglia are intrinsic components of the central nervous system (CNS. During pathologies in mammals, inflammatory processes implicate the resident microglia and the infiltration of blood cells including macrophages. Functions of microglia appear to be complex as they exhibit both neuroprotective and neurotoxic effects during neuropathological conditions in vivo and in vitro. The medicinal leech Hirudo medicinalis is a well-known model in neurobiology due to its ability to naturally repair its CNS following injury. Considering the low infiltration of blood cells in this process, the leech CNS is studied to specify the activation mechanisms of only resident microglial cells. The microglia recruitment is known to be essential for the usual sprouting of injured axons and does not require any other glial cells. The present review will describe the questions which are addressed to understand the nerve repair. They will discuss the implication of leech factors in the microglial accumulation, the identification of nerve cells producing these molecules, and the study of different microglial subsets. Those questions aim to better understand the mechanisms of microglial cell recruitment and their crosstalk with damaged neurons. The study of this dialog is necessary to elucidate the balance of the inflammation leading to the leech CNS repair.

  12. Beyond the Didactic Classroom: Educational Models to Encourage Active Student Involvement in Learning

    Science.gov (United States)

    Shreeve, Michael W.

    2008-01-01

    In a chiropractic college that utilizes a hybrid curriculum model composed of adult-based learning strategies along with traditional lecture-based course delivery, a literature search for educational delivery methods that would integrate the affective domain and the cognitive domain of learning provided some insights into the use of problem-based learning (PBL), experiential learning theory (ELT), and the emerging use of appreciative inquiry (AI) to enhance the learning experience. The purpose of this literature review is to provide a brief overview of key components of PBL, ELT, and AI in educational methodology and to discuss how these might be used within the chiropractic curriculum to supplement traditional didactic lecture courses. A growing body of literature describes the use of PBL and ELT in educational settings across many disciplines, both at the undergraduate and graduate levels. The use of appreciative inquiry as an instructional methodology presents a new area for exploration and study in the academic environment. Educational research in the chiropractic classroom incorporating ELT and appreciative inquiry might provide some valuable insights for future curriculum development. PMID:18483586

  13. Beyond the didactic classroom: educational models to encourage active student involvement in learning.

    Science.gov (United States)

    Shreeve, Michael W

    2008-01-01

    In a chiropractic college that utilizes a hybrid curriculum model composed of adult-based learning strategies along with traditional lecture-based course delivery, a literature search for educational delivery methods that would integrate the affective domain and the cognitive domain of learning provided some insights into the use of problem-based learning (PBL), experiential learning theory (ELT), and the emerging use of appreciative inquiry (AI) to enhance the learning experience. The purpose of this literature review is to provide a brief overview of key components of PBL, ELT, and AI in educational methodology and to discuss how these might be used within the chiropractic curriculum to supplement traditional didactic lecture courses. A growing body of literature describes the use of PBL and ELT in educational settings across many disciplines, both at the undergraduate and graduate levels. The use of appreciative inquiry as an instructional methodology presents a new area for exploration and study in the academic environment. Educational research in the chiropractic classroom incorporating ELT and appreciative inquiry might provide some valuable insights for future curriculum development.

  14. Analysis of two-body nonleptonic B decays involving light mesons in the standard model

    Science.gov (United States)

    Ali, A.; Greub, C.

    1998-03-01

    We report a theoretical analysis of the exclusive nonleptonic decays of the B+/- and B0 mesons into two light mesons, some of which have been measured recently by the CLEO Collaboration. Our analysis is carried out in the context of an effective Hamiltonian based on the standard model (SM), using next-to-leading order perturbative QCD calculations. We explicitly take into account the O(αs) penguin-loop diagrams of all four-Fermi operators and the O(αs) tree-level diagram of the chromomagnetic dipole operator, and give a prescription for including their effects in nonleptonic two-body decays. Using a factorization ansatz for the hadronic matrix elements, we show that existing data, in particular, the branching ratios B(B+/--->η'K+/-), B(B+/--->π+/-K0), B(B0(B0¯)-->π-/+K+/-), and B(B+/--->ωh+/-)(h+/-=π+/-,K+/-), can be accounted for in this approach. Thus, theoretical scenarios with a substantially enhanced Wilson coefficient of the chromomagnetic dipole operator (as compared to the SM) and/or those with a substantial color-singlet cc¯ component in the wave function of η' are not required by these data. We predict, among other decay rates, the branching ratios for the decays B0(B0¯)-->π+/-π-/+ and B+/--->π0π+/-, which are close to the present experimental limits. Implications of some of these measurements for the parameters of the CKM matrix are presented.

  15. The Undergraduate ALFALFA Team: A Model for Involving Undergraduates in Major Legacy Astronomy Research

    Science.gov (United States)

    Troischt, Parker; Koopmann, Rebecca A.; Haynes, Martha P.; Higdon, Sarah; Balonek, Thomas J.; Cannon, John M.; Coble, Kimberly A.; Craig, David; Durbala, Adriana; Finn, Rose; Hoffman, G. Lyle; Kornreich, David A.; Lebron, Mayra E.; Crone-Odekon, Mary; O'Donoghue, Aileen A.; Olowin, Ronald Paul; Pantoja, Carmen; Rosenberg, Jessica L.; Venkatesan, Aparna; Wilcots, Eric M.; Alfalfa Team

    2015-01-01

    The NSF-sponsored Undergraduate ALFALFA (Arecibo Legacy Fast ALFA) Team (UAT) is a consortium of 19 institutions founded to promote undergraduate research and faculty development within the extragalactic ALFALFA HI blind survey project and follow-up programs. The collaborative nature of the UAT allows faculty and students from a wide ​range of public and private colleges and especially those with small astronomy programs to develop scholarly collaborations. Components of the program include an annual undergraduate workshop at Arecibo Observatory, observing runs at Arecibo, computer infrastructure, summer and academic year research projects, and dissemination at national meetings (e.g., Alfvin et al., Martens et al., Sanders et al., this meeting). Through this model, faculty and students are learning how science is accomplished in a large collaboration while contributing to the scientific goals of a major legacy survey. In the 7 years of the program, 23 faculty and more than 220 undergraduate students have participated at a significant level. 40% of them have been women and members of underrepresented groups. Faculty, many of whom were new to the collaboration and had expertise in other fields, contribute their diverse sets of skills to ALFALFA ​related projects via observing, data reduction, collaborative research, and research with students. 142 undergraduate students have attended the annual workshops at Arecibo Observatory, interacting with faculty, graduate students, their peers, and Arecibo staff in lectures, group activities, tours, and observing runs. Team faculty have supervised 131 summer research projects and 94 academic year (e.g., senior thesis) projects. 62 students have traveled to Arecibo Observatory for observing runs and 46 have presented their results at national meetings. 93% of alumni are attending graduate school and/or pursuing a career in STEM. Half of those pursuing graduate degrees in Physics or Astronomy are women. This work has been

  16. A model approach to vanadium involvement in crude oils and their refining. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Christou, G.

    1994-04-01

    Heavy crude oils contain a large amount of metal impurities, primarily vanadium species. These comprise both vanadyl porphyrins and vanadyl non-porphyrins. During hydrotreating of crude oils (reaction with H{sub 2} over a supported Mo/S catalyst at 350-- 450{degrees}C) for upgrading to usable products the V impurities are converted to insoluble V sulfides which help poison the fixed-bed Mo catalyst. Very little is known about the chemistry occurring at a detailed level; basically, it is known that initial impurities are vanadyl (VO){sup 2+}, i.e., V{sup IV} species, and that during the refining processes they are reduced and sulfided into polymers, i.e., the metal is reduced from V{sup IV} to {approximately} V{sup III}, the oxo is lost, the organic ligation is lost, and the metal is sulfided. In what order and in precisely what manner this overall transformation is occurring is not known. The essence of our research efforts is to develop vanadium chemistry of relevance to this area and to thereby provide fundamental information on the transformations occurring and that might prove useful in catalyst design. Our work has encompassed the study of the reactivity chemistry of [VO]{sup 2+} species and the formation and characterization of V/S aggregates under conditions designed to mimic those present under hydrotreating conditions. Thus, we are applying an Inorganic Model Approach to provide insights into the chemistry occurring during the refining process. Our emphasis has been on definitive characterization of products using a variety of physical techniques,including X-ray crystallography. Our work covers the following areas, each of which is described: studies in V/O{sup 2+} chemistry; V{sup III}/O chemistry; V/S complexes; and absorption of [VO]{sup 2+} groups on catalyst surfaces.

  17. Can the Epstein Model of Parental Involvement Work in a High-Minority, High-Poverty Elementary School? A Case Study

    Science.gov (United States)

    Bower, Heather A.; Griffin, Dana

    2011-01-01

    The literature has lauded parental involvement as an effective strategy to increase student achievement, but schools still struggle with how to effectively involve parents of color and low-income families. In an effort to assess the effectiveness of the Epstein Model of Parental Involvement in high-poverty, high-minority schools, the authors…

  18. Can the Epstein Model of Parental Involvement Work in a High-Minority, High-Poverty Elementary School? A Case Study

    Science.gov (United States)

    Bower, Heather A.; Griffin, Dana

    2011-01-01

    The literature has lauded parental involvement as an effective strategy to increase student achievement, but schools still struggle with how to effectively involve parents of color and low-income families. In an effort to assess the effectiveness of the Epstein Model of Parental Involvement in high-poverty, high-minority schools, the authors…

  19. Some typical solid propellant rocket motors

    NARCIS (Netherlands)

    Zandbergen, B.T.C.

    2013-01-01

    Typical Solid Propellant Rocket Motors (shortly referred to as Solid Rocket Motors; SRM's) are described with the purpose to form a database, which allows for comparative analysis and applications in practical SRM engineering.

  20. Some typical solid propellant rocket motors

    NARCIS (Netherlands)

    Zandbergen, B.T.C.

    2013-01-01

    Typical Solid Propellant Rocket Motors (shortly referred to as Solid Rocket Motors; SRM's) are described with the purpose to form a database, which allows for comparative analysis and applications in practical SRM engineering.

  1. Prediction and typicality in multiverse cosmology

    Science.gov (United States)

    Azhar, Feraz

    2014-02-01

    In the absence of a fundamental theory that precisely predicts values for observable parameters, anthropic reasoning attempts to constrain probability distributions over those parameters in order to facilitate the extraction of testable predictions. The utility of this approach has been vigorously debated of late, particularly in light of theories that claim we live in a multiverse, where parameters may take differing values in regions lying outside our observable horizon. Within this cosmological framework, we investigate the efficacy of top-down anthropic reasoning based on the weak anthropic principle. We argue contrary to recent claims that it is not clear one can either dispense with notions of typicality altogether or presume typicality, in comparing resulting probability distributions with observations. We show in a concrete, top-down setting related to dark matter, that assumptions about typicality can dramatically affect predictions, thereby providing a guide to how errors in reasoning regarding typicality translate to errors in the assessment of predictive power. We conjecture that this dependence on typicality is an integral feature of anthropic reasoning in broader cosmological contexts, and argue in favour of the explicit inclusion of measures of typicality in schemes invoking anthropic reasoning, with a view to extracting predictions from multiverse scenarios.

  2. Spectra of conditionalization and typicality in the multiverse

    CERN Document Server

    Azhar, Feraz

    2016-01-01

    An approach to testing theories describing a multiverse, that has gained interest of late, involves comparing theory-generated probability distributions over observables with their experimentally measured values. It is likely that such distributions, were we indeed able to calculate them unambiguously, will assign low probabilities to any such experimental measurements. An alternative to thereby rejecting these theories, is to conditionalize the distributions involved by restricting attention to domains of the multiverse in which we might arise. In order to elicit a crisp prediction, however, one needs to make a further assumption about how typical we are of the chosen domains. In this paper, we investigate interactions between the spectra of available assumptions regarding both conditionalization and typicality, and draw out the effects of these interactions in a concrete setting; namely, on predictions of the total number of species that contribute significantly to dark matter. In particular, for each condi...

  3. What is typical is good: the influence of face typicality on perceived trustworthiness.

    Science.gov (United States)

    Sofer, Carmel; Dotsch, Ron; Wigboldus, Daniel H J; Todorov, Alexander

    2015-01-01

    The role of face typicality in face recognition is well established, but it is unclear whether face typicality is important for face evaluation. Prior studies have focused mainly on typicality's influence on attractiveness, although recent studies have cast doubt on its importance for attractiveness judgments. Here, we argue that face typicality is an important factor for social perception because it affects trustworthiness judgments, which approximate the basic evaluation of faces. This effect has been overlooked because trustworthiness and attractiveness judgments have a high level of shared variance for most face samples. We show that for a continuum of faces that vary on a typicality-attractiveness dimension, trustworthiness judgments peak around the typical face. In contrast, perceived attractiveness increases monotonically past the typical face, as faces become more like the most attractive face. These findings suggest that face typicality is an important determinant of face evaluation.

  4. How typical are 'typical' tremor characteristics? : Sensitivity and specificity of five tremor phenomena

    NARCIS (Netherlands)

    van der Stouwe, A. M. M.; Elting, J. W.; van der Hoeven, J. H.; van Laar, T.; Leenders, K. L.; Maurits, N. M.; Tijssen, M. Aj.

    2016-01-01

    Introduction: Distinguishing between different tremor disorders can be challenging. Some tremor disorders are thought to have typical tremor characteristics: the current study aims to provide sensitivity and specificity for five 'typical' tremor phenomena. Methods: Retrospectively, we examined 210 t

  5. Multiscale method for modeling binding phenomena involving large objects: application to kinesin motor domains motion along microtubules.

    Science.gov (United States)

    Li, Lin; Alper, Joshua; Alexov, Emil

    2016-03-18

    Many biological phenomena involve the binding of proteins to a large object. Because the electrostatic forces that guide binding act over large distances, truncating the size of the system to facilitate computational modeling frequently yields inaccurate results. Our multiscale approach implements a computational focusing method that permits computation of large systems without truncating the electrostatic potential and achieves the high resolution required for modeling macromolecular interactions, all while keeping the computational time reasonable. We tested our approach on the motility of various kinesin motor domains. We found that electrostatics help guide kinesins as they walk: N-kinesins towards the plus-end, and C-kinesins towards the minus-end of microtubules. Our methodology enables computation in similar, large systems including protein binding to DNA, viruses, and membranes.

  6. What is typical is good: The influence of face typicality on perceived trustworthiness

    NARCIS (Netherlands)

    Sofer, C.; Dotsch, R.; Wigboldus, D.H.J.; Todorov, A.T.

    2015-01-01

    The role of face typicality in face recognition is well established, but it is unclear whether face typicality is important for face evaluation. Prior studies have focused mainly on typicality's influence on attractiveness, although recent studies have cast doubt on its importance for attractiveness

  7. Identification of protein networks involved in the disease course of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.

    Directory of Open Access Journals (Sweden)

    Annelies Vanheel

    Full Text Available A more detailed insight into disease mechanisms of multiple sclerosis (MS is crucial for the development of new and more effective therapies. MS is a chronic inflammatory autoimmune disease of the central nervous system. The aim of this study is to identify novel disease associated proteins involved in the development of inflammatory brain lesions, to help unravel underlying disease processes. Brainstem proteins were obtained from rats with MBP induced acute experimental autoimmune encephalomyelitis (EAE, a well characterized disease model of MS. Samples were collected at different time points: just before onset of symptoms, at the top of the disease and following recovery. To analyze changes in the brainstem proteome during the disease course, a quantitative proteomics study was performed using two-dimensional difference in-gel electrophoresis (2D-DIGE followed by mass spectrometry. We identified 75 unique proteins in 92 spots with a significant abundance difference between the experimental groups. To find disease-related networks, these regulated proteins were mapped to existing biological networks by Ingenuity Pathway Analysis (IPA. The analysis revealed that 70% of these proteins have been described to take part in neurological disease. Furthermore, some focus networks were created by IPA. These networks suggest an integrated regulation of the identified proteins with the addition of some putative regulators. Post-synaptic density protein 95 (DLG4, a key player in neuronal signalling and calcium-activated potassium channel alpha 1 (KCNMA1, involved in neurotransmitter release, are 2 putative regulators connecting 64% of the identified proteins. Functional blocking of the KCNMA1 in macrophages was able to alter myelin phagocytosis, a disease mechanism highly involved in EAE and MS pathology. Quantitative analysis of differentially expressed brainstem proteins in an animal model of MS is a first step to identify disease-associated proteins and

  8. Prediction and typicality in multiverse cosmology

    CERN Document Server

    Azhar, Feraz

    2015-01-01

    In the absence of a fundamental theory that precisely predicts values for observable parameters, anthropic reasoning attempts to constrain probability distributions over those parameters in order to facilitate the extraction of testable predictions. The utility of this approach has been vigorously debated of late, particularly in light of theories that claim we live in a multiverse, where parameters may take differing values in regions lying outside our observable horizon. Within this cosmological framework, we investigate the efficacy of top-down anthropic reasoning based on the weak anthropic principle. We argue contrary to recent claims that it is not clear one can either dispense with notions of typicality altogether or presume typicality, in comparing resulting probability distributions with observations. We show in a concrete, top-down setting related to dark matter, that assumptions about typicality can dramatically affect predictions, thereby providing a guide to how errors in reasoning regarding typi...

  9. Identification of genes and pathways involved in retinal neovascularization by microarray analysis of two animal models of retinal angiogenesis.

    Science.gov (United States)

    Recchia, Franco M; Xu, Lili; Penn, John S; Boone, Braden; Dexheimer, Phillip J

    2010-02-01

    Comparative retinal gene expression analysis in two rodent models of oxygen-induced retinopathy (OIR) was performed to identify the genes and pathways involved in retinal neovascularization. Three independent experimental runs were conducted for each species, according to standard protocols for induction of OIR. Total retinal RNA was isolated at two time points, corresponding to the early response to relative hypoxia (P13 in mouse, P15 in rat) and to the later phase of maximum retinal neovascularization (P18 in mouse, P20 in rat) and was used to prepare labeled probes for hybridization. Gene expression was compared between normal and experimental conditions for each species at each time point. Probesets with a false-discovery rate of models. At the later time point, there were changes in 26 genes in the rat and in 1622 in the mouse, with 13 in common. Four pathways were identified in both models. Genes and pathways known to be involved in angiogenesis, as well as other biologically plausible genes and pathways, were identified. This work serves as a comprehensive resource for the study of retinal neovascularization and identification of potential rational targets for antiangiogenic therapy.

  10. Typical horticultural products between tradition and innovation

    Directory of Open Access Journals (Sweden)

    Innocenza Chessa

    2009-10-01

    Full Text Available Recent EU and National policies for agriculture and rural development are mainly focused to foster the production of high quality products as a result of the increasing demand of food safety, typical foods and traditional processing methods. Another word very often used to describe foods in these days is “typicality” which pools together the concepts of “food connected with a specific place”, “historical memory and tradition” and “culture”. The importance for the EU and the National administrations of the above mentioned kind of food is demonstrated, among other things, by the high number of the PDO, PGI and TSG certificated products in Italy. In this period of global markets and economical crisis farmers are realizing how “typical products” can be an opportunity to maintain their market share and to improve the economy of local areas. At the same time, new tools and strategy are needed to reach these goals. A lack of knowledge has being recognized also on how new technologies and results coming from recent research can help in exploiting traditional product and in maintaining the biodiversity. Taking into account the great variety and richness of typical products, landscapes and biodiversity, this report will describe and analyze the relationships among typicality, innovation and research in horticulture. At the beginning “typicality” and “innovation” will be defined also through some statistical features, which ranks Italy at the first place in terms of number of typical labelled products, then will be highlighted how typical products of high quality and connected with the tradition and culture of specific production areas are in a strict relationship with the value of agro-biodiversity. Several different examples will be used to explain different successful methods and/or strategies used to exploit and foster typical Italian vegetables, fruits and flowers. Finally, as a conclusion, since it is thought that

  11. Differential expression of genes involved in the degeneration and regeneration pathways in mouse models for muscular dystrophies.

    Science.gov (United States)

    Onofre-Oliveira, P C G; Santos, A L F; Martins, P M; Ayub-Guerrieri, D; Vainzof, M

    2012-03-01

    The genetically determined muscular dystrophies are caused by mutations in genes coding for muscle proteins. Differences in the phenotypes are mainly the age of onset and velocity of progression. Muscle weakness is the consequence of myofiber degeneration due to an imbalance between successive cycles of degeneration/regeneration. While muscle fibers are lost, a replacement of the degraded muscle fibers by adipose and connective tissues occurs. Major investigation points are to elicit the involved pathophysiological mechanisms to elucidate how each mutation can lead to a specific degenerative process and how the regeneration is stimulated in each case. To answer these questions, we used four mouse models with different mutations causing muscular dystrophies, Dmd (mdx), SJL/J, Large (myd) and Lama2 (dy2J) /J, and compared the histological changes of regeneration and fibrosis to the expression of genes involved in those processes. For regeneration, the MyoD, Myf5 and myogenin genes related to the proliferation and differentiation of satellite cells were studied, while for degeneration, the TGF-β1 and Pro-collagen 1α2 genes, involved in the fibrotic cascade, were analyzed. The result suggests that TGF-β1 gene is activated in the dystrophic process in all the stages of degeneration, while the activation of the expression of the pro-collagen gene possibly occurs in mildest stages of this process. We also observed that each pathophysiological mechanism acted differently in the activation of regeneration, with distinctions in the induction of proliferation of satellite cells, but with no alterations in stimulation to differentiation. Dysfunction of satellite cells can, therefore, be an important additional mechanism of pathogenesis in the dystrophic muscle.

  12. Zebrafish larva as a reliable model for in vivo assessment of membrane remodeling involvement in the hepatotoxicity of chemical agents.

    Science.gov (United States)

    Podechard, Normand; Chevanne, Martine; Fernier, Morgane; Tête, Arnaud; Collin, Aurore; Cassio, Doris; Kah, Olivier; Lagadic-Gossmann, Dominique; Sergent, Odile

    2016-11-28

    The easy-to-use in vivo model, zebrafish larva, is being increasingly used to screen chemical-induced hepatotoxicity, with a good predictivity for various mechanisms of liver injury. However, nothing is known about its applicability in exploring the mechanism called membrane remodeling, depicted as changes in membrane fluidity or lipid raft properties. The aim of this study was, therefore, to substantiate the zebrafish larva as a suitable in vivo model in this context. Ethanol was chosen as a prototype toxicant because it is largely described, both in hepatocyte cultures and in rodents, as capable of inducing a membrane remodeling leading to hepatocyte death and liver injury. The zebrafish larva model was demonstrated to be fully relevant as membrane remodeling was maintained even after a 1-week exposure without any adaptation as usually reported in rodents and hepatocyte cultures. It was also proven to exhibit a high sensitivity as it discriminated various levels of cytotoxicity depending on the extent of changes in membrane remodeling. In this context, its sensitivity appeared higher than that of WIF-B9 hepatic cells, which is suited for analyzing this kind of hepatotoxicity. Finally, the protection afforded by a membrane stabilizer, ursodeoxycholic acid (UDCA), or by a lipid raft disrupter, pravastatin, definitely validated zebrafish larva as a reliable model to quickly assess membrane remodeling involvement in chemical-induced hepatotoxicity. In conclusion, this model, compatible with a high throughput screening, might be adapted to seek hepatotoxicants via membrane remodeling, and also drugs targeting membrane features to propose new preventive or therapeutic strategies in chemical-induced liver diseases. Copyright © 2016 John Wiley & Sons, Ltd.

  13. A hidden Markov model to identify and adjust for selection bias: an example involving mixed migration strategies.

    Science.gov (United States)

    Fieberg, John R; Conn, Paul B

    2014-05-01

    An important assumption in observational studies is that sampled individuals are representative of some larger study population. Yet, this assumption is often unrealistic. Notable examples include online public-opinion polls, publication biases associated with statistically significant results, and in ecology, telemetry studies with significant habitat-induced probabilities of missed locations. This problem can be overcome by modeling selection probabilities simultaneously with other predictor-response relationships or by weighting observations by inverse selection probabilities. We illustrate the problem and a solution when modeling mixed migration strategies of northern white-tailed deer (Odocoileus virginianus). Captures occur on winter yards where deer migrate in response to changing environmental conditions. Yet, not all deer migrate in all years, and captures during mild years are more likely to target deer that migrate every year (i.e., obligate migrators). Characterizing deer as conditional or obligate migrators is also challenging unless deer are observed for many years and under a variety of winter conditions. We developed a hidden Markov model where the probability of capture depends on each individual's migration strategy (conditional versus obligate migrator), a partially latent variable that depends on winter severity in the year of capture. In a 15-year study, involving 168 white-tailed deer, the estimated probability of migrating for conditional migrators increased nonlinearly with an index of winter severity. We estimated a higher proportion of obligates in the study cohort than in the population, except during a span of 3 years surrounding back-to-back severe winters. These results support the hypothesis that selection biases occur as a result of capturing deer on winter yards, with the magnitude of bias depending on the severity of winter weather. Hidden Markov models offer an attractive framework for addressing selection biases due to their

  14. Treadmill Exercise Prevents Increase of Neuroinflammation Markers Involved in the Dopaminergic Damage of the 6-OHDA Parkinson's Disease Model.

    Science.gov (United States)

    Real, Caroline Cristiano; Garcia, Priscila Crespo; Britto, Luiz R G

    2017-08-11

    Parkinson's disease (PD) involves loss of dopaminergic neurons in the substantia nigra (SN), which can be correlated to neuroinflammatory changes with the aging of the nervous system. On the other hand, exercise can reduce the deleterious effects promoted by age, but the mechanism involved is still unclear. This study investigated the preventive exercise-induced changes on neuroinflammatory processes in a rat model of PD induced by unilateral striatal injections of 6-hydroxydopamine (6-OHDA). Adult male Wistar rats were divided into two groups: (1) sedentary (SED) or (2) exercised (EX), animals that did treadmill exercise three times per week, every other day, for 4 weeks prior to 6-OHDA or saline injection. The rats were then divided into four sub-groups: (1) sedentary saline (SED), (2) sedentary 6-OHDA (SED + 6-OHDA), (3) exercised saline (EX), and (4) exercised 6-OHDA (EX + 6-OHDA). Seven and 30 days after surgery, brains were collected for immunohistochemistry and immunoblotting for dopaminergic and neuroinflammatory markers into SN and striatum. The SED + 6-OHDA animals presented an increase in the astrocyte, microglial, and oxidative species activation. On the other hand, EX + 6-OHDA animals did not present neuroinflammatory responses and performed better apormorphine test. Our data suggest that treadmill exercise throughout life can markedly reduce the chances of dopamine decrease, reinforcing studies that showed a lower incidence of Parkinson's disease in patients who were active during life.

  15. Dynamic Analysis of a Predator-Prey (Pest Model with Disease in Prey and Involving an Impulsive Control Strategy

    Directory of Open Access Journals (Sweden)

    Min Zhao

    2012-01-01

    Full Text Available The dynamic behaviors of a predator-prey (pest model with disease in prey and involving an impulsive control strategy to release infected prey at fixed times are investigated for the purpose of integrated pest management. Mathematical theoretical works have been pursuing the investigation of the local asymptotical stability and global attractivity for the semitrivial periodic solution and population persistent, which depicts the threshold expression of some critical parameters for carrying out integrated pest management. Numerical analysis indicates that the impulsive control strategy has a strong effect on the dynamical complexity and population persistent using bifurcation diagrams and power spectra diagrams. These results show that if the release amount of infective prey can satisfy some critical conditions, then all biological populations will coexist. All these results are expected to be of use in the study of the dynamic complexity of ecosystems.

  16. Entanglement Dynamics in Typical Local- and Normal-Mode Molecules

    Institute of Scientific and Technical Information of China (English)

    HOU Xi-Wen; WAN Ming-Fang; MA Zhong-Qi

    2007-01-01

    The entanglement dynamics of two stretching vibrations in theoretically typical local- and normal-mode molecules and realistic molecules H2O and SO2 in an algebraic model is studied in terms of the reduced-density linear entropy with initial entangled states taken to be two-mode squeezed vacuum states. It is shown that the behaviour of the entropy in theoretically typical molecules appears to be more regular than that in realistic ones, and that the entropy becomes irregular as the amplitude of two-mode squeezed vacuum states increases. For initial states with a small amplitude, it is demonstrated that the periodicity and the "classical" beat phenomenon of the entropy occur with the beat in theoretically typical molecules being more regular than that in realistic molecules H2O and SO2.

  17. Parental Involvement

    OpenAIRE

    Ezra S Simon

    2008-01-01

    This study was conducted in Ghana to investigate, (1) factors that predict parental involvement, (2) the relationship between parental home and school involvement and the educational achievement of adolescents, (3) the relationship between parental authoritativeness and the educational achievement of adolescent students, (4) parental involvement serving as a mediator between their authoritativeness and the educational achievement of the students, and (5) whether parental involvement decreases...

  18. Newt tail regeneration: a model for gravity-dependent morphogenesis and clues to the molecular mechanisms involved.

    Science.gov (United States)

    Radugina, Elena A.; Almeida, Eduardo; Grigoryan, Eleonora

    factors and are expressed during development, we hypothesized they may play a role newt tail regenerative morphogenesis under altered g-levels. Specifically there is increasing evidence for HSPs expression changes as a result of hyper-and microgravity. HSPs are also expressed throughout regeneration, rather than just after surgery. To test this hypothesis we performed heat shock on intact and regenerating newts and collected tail tissues. In these experiments we observed that some tails had uplifted tips while others mimicked hook-like regenerates at 1g or 2g. These findings suggest that heat shock, and HSPs induction, may be involved in the mechanism responsible for gravity effects on morphogenesis, or at least interact with them. Current work underway is focused on analyzing the expression of mRNA and localization of proteins for two members of the group, Hsp70 and Hsp90. In summary, we developed and characterized a new practical animal model in which gravity mechanostimulation at 1g, versus unloading in aquaria, causes prominent effects on newt tail regenerative morphogenesis. This model can be achieved without the use of a centrifuge, significantly simplifying its research applications. Initial results using this model suggest that induction of HSPs may be involved in gravity regulation of newt tail regenerative morphogenesis. Further research based on this simple model may help to unravel mechanisms of gravity influence relevant not only to newt tail regeneration, but also to a broad range of other biological processes in amphibian models.

  19. Molecular modeling and simulation of FabG, an enzyme involved in the fatty acid pathway of Streptococcus pyogenes.

    Science.gov (United States)

    Shafreen, Rajamohmed Beema; Pandian, Shunmugiah Karutha

    2013-09-01

    Streptococcus pyogenes (SP) is the major cause of pharyngitis accompanied by strep throat infections in humans. 3-keto acyl reductase (FabG), an important enzyme involved in the elongation cycle of the fatty acid pathway of S. pyogenes, is essential for synthesis of the cell-membrane, virulence factors and quorum sensing-related mechanisms. Targeting SPFabG may provide an important aid for the development of drugs against S. pyogenes. However, the absence of a crystal structure for FabG of S. pyogenes limits the development of structure-based drug designs. Hence, in the present study, a homology model of FabG was generated using the X-ray crystallographic structure of Aquifex aeolicus (PDB ID: 2PNF). The modeled structure was refined using energy minimization. Furthermore, active sites were predicted, and a large dataset of compounds was screened against SPFabG. The ligands were docked using the LigandFit module that is available from Discovery Studio version 2.5. From this list, 13 best hit ligands were chosen based on the docking score and binding energy. All of the 13 ligands were screened for Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) properties. From this, the two best descriptors, along with one descriptor that lay outside the ADMET plot, were selected for molecular dynamic (MD) simulation. In vitro testing of the ligands using biological assays further substantiated the efficacy of the ligands that were screened based on the in silico methods.

  20. Estrogen Receptor (ER-α36 Is Involved in Estrogen- and Tamoxifen-Induced Neuroprotective Effects in Ischemic Stroke Models.

    Directory of Open Access Journals (Sweden)

    Wei Zou

    Full Text Available The neuroprotection by estrogen (E2 and tamoxifen is well documented in experimental stroke models; however, the exact mechanism is unclear. A membrane-based estrogen receptor, ER-α36, has been identified. Postmenopausal-levels of E2 act through ER-α36 to induce osteoclast apoptosis due to a prolonged activation of the mitogen-activated protein kinase (MAPK/extracellular signal-related kinase (ERK signaling. We hypothesized that ER-α36 may play a role in the neuroprotective activities of estrogen and tamoxifen. Here, we studied ER-α36 expression in the brain, as well as its neuroprotective effects against oxygen and glucose deprivation (OGD in PC12 cells. We found that ER-α36 was expressed in both rat and human brain. In addition, OGD-induced cell death was prevented by l nmol/L 17β-estradiol (E2β. E2β activates the MAPK/ERK signaling pathway in PC12 cells under basal and OGD conditions by interacting with ER-α36 and also induces ER-α36 expression. Low-dose of tamoxifen up-regulated ER-α36 expression and enhanced neuronal survival in an ovariectomized ischemic stroke model. Furthermore, low-dose of tamoxifen enhanced neuroprotective effects by modulating activates or suppress ER-α36. Our results thus demonstrated that ER-α36 is involved in neuroprotective activities mediated by both estrogen and tamoxifen.

  1. Modeling retrospective attribution of responsibility to hazard-managing institutions: an example involving a food contamination incident.

    Science.gov (United States)

    Johnson, Branden B; Hallman, William K; Cuite, Cara L

    2015-03-01

    Perceptions of institutions that manage hazards are important because they can affect how the public responds to hazard events. Antecedents of trust judgments have received far more attention than antecedents of attributions of responsibility for hazard events. We build upon a model of retrospective attribution of responsibility to individuals to examine these relationships regarding five classes of institutions that bear responsibility for food safety: producers (e.g., farmers), processors (e.g., packaging firms), watchdogs (e.g., government agencies), sellers (e.g., supermarkets), and preparers (e.g., restaurants). A nationally representative sample of 1,200 American adults completed an Internet-based survey in which a hypothetical scenario involving contamination of diverse foods with Salmonella served as the stimulus event. Perceived competence and good intentions of the institution moderately decreased attributions of responsibility. A stronger factor was whether an institution was deemed (potentially) aware of the contamination and free to act to prevent or mitigate it. Responsibility was rated higher the more aware and free the institution. This initial model for attributions of responsibility to impersonal institutions (as opposed to individual responsibility) merits further development. © 2014 Society for Risk Analysis.

  2. Group typicality, group loyalty and cognitive development.

    Science.gov (United States)

    Patterson, Meagan M

    2014-09-01

    Over the course of childhood, children's thinking about social groups changes in a variety of ways. Developmental Subjective Group Dynamics (DSGD) theory emphasizes children's understanding of the importance of conforming to group norms. Abrams et al.'s study, which uses DSGD theory as a framework, demonstrates the social cognitive skills underlying young elementary school children's thinking about group norms. Future research on children's thinking about groups and group norms should explore additional elements of this topic, including aspects of typicality beyond loyalty.

  3. Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions with Efavirenz Involving Simultaneous Inducing and Inhibitory Effects on Cytochromes.

    Science.gov (United States)

    Marzolini, Catia; Rajoli, Rajith; Battegay, Manuel; Elzi, Luigia; Back, David; Siccardi, Marco

    2017-04-01

    Antiretroviral drugs are among the therapeutic agents with the highest potential for drug-drug interactions (DDIs). In the absence of clinical data, DDIs are mainly predicted based on preclinical data and knowledge of the disposition of individual drugs. Predictions can be challenging, especially when antiretroviral drugs induce and inhibit multiple cytochrome P450 (CYP) isoenzymes simultaneously. This study predicted the magnitude of the DDI between efavirenz, an inducer of CYP3A4 and inhibitor of CYP2C8, and dual CYP3A4/CYP2C8 substrates (repaglinide, montelukast, pioglitazone, paclitaxel) using a physiologically based pharmacokinetic (PBPK) modeling approach integrating concurrent effects on CYPs. In vitro data describing the physicochemical properties, absorption, distribution, metabolism, and elimination of efavirenz and CYP3A4/CYP2C8 substrates as well as the CYP-inducing and -inhibitory potential of efavirenz were obtained from published literature. The data were integrated in a PBPK model developed using mathematical descriptions of molecular, physiological, and anatomical processes defining pharmacokinetics. Plasma drug-concentration profiles were simulated at steady state in virtual individuals for each drug given alone or in combination with efavirenz. The simulated pharmacokinetic parameters of drugs given alone were compared against existing clinical data. The effect of efavirenz on CYP was compared with published DDI data. The predictions indicate that the overall effect of efavirenz on dual CYP3A4/CYP2C8 substrates is induction of metabolism. The magnitude of induction tends to be less pronounced for dual CYP3A4/CYP2C8 substrates with predominant CYP2C8 metabolism. PBPK modeling constitutes a useful mechanistic approach for the quantitative prediction of DDI involving simultaneous inducing or inhibitory effects on multiple CYPs as often encountered with antiretroviral drugs.

  4. Expression profiles of genes involved in xenobiotic metabolism and disposition in human renal tissues and renal cell models

    Energy Technology Data Exchange (ETDEWEB)

    Van der Hauwaert, Cynthia; Savary, Grégoire [EA4483, Université de Lille 2, Faculté de Médecine de Lille, Pôle Recherche, 59045 Lille (France); Buob, David [Institut de Pathologie, Centre de Biologie Pathologie Génétique, Centre Hospitalier Régional Universitaire de Lille, 59037 Lille (France); Leroy, Xavier; Aubert, Sébastien [Institut de Pathologie, Centre de Biologie Pathologie Génétique, Centre Hospitalier Régional Universitaire de Lille, 59037 Lille (France); Institut National de la Santé et de la Recherche Médicale, UMR837, Centre de Recherche Jean-Pierre Aubert, Equipe 5, 59045 Lille (France); Flamand, Vincent [Service d' Urologie, Hôpital Huriez, Centre Hospitalier Régional Universitaire de Lille, 59037 Lille (France); Hennino, Marie-Flore [EA4483, Université de Lille 2, Faculté de Médecine de Lille, Pôle Recherche, 59045 Lille (France); Service de Néphrologie, Hôpital Huriez, Centre Hospitalier Régional Universitaire de Lille, 59037 Lille (France); Perrais, Michaël [Institut National de la Santé et de la Recherche Médicale, UMR837, Centre de Recherche Jean-Pierre Aubert, Equipe 5, 59045 Lille (France); and others

    2014-09-15

    Numerous xenobiotics have been shown to be harmful for the kidney. Thus, to improve our knowledge of the cellular processing of these nephrotoxic compounds, we evaluated, by real-time PCR, the mRNA expression level of 377 genes encoding xenobiotic-metabolizing enzymes (XMEs), transporters, as well as nuclear receptors and transcription factors that coordinate their expression in eight normal human renal cortical tissues. Additionally, since several renal in vitro models are commonly used in pharmacological and toxicological studies, we investigated their metabolic capacities and compared them with those of renal tissues. The same set of genes was thus investigated in HEK293 and HK2 immortalized cell lines in commercial primary cultures of epithelial renal cells and in proximal tubular cell primary cultures. Altogether, our data offers a comprehensive description of kidney ability to process xenobiotics. Moreover, by hierarchical clustering, we observed large variations in gene expression profiles between renal cell lines and renal tissues. Primary cultures of proximal tubular epithelial cells exhibited the highest similarities with renal tissue in terms of transcript profiling. Moreover, compared to other renal cell models, Tacrolimus dose dependent toxic effects were lower in proximal tubular cell primary cultures that display the highest metabolism and disposition capacity. Therefore, primary cultures appear to be the most relevant in vitro model for investigating the metabolism and bioactivation of nephrotoxic compounds and for toxicological and pharmacological studies. - Highlights: • Renal proximal tubular (PT) cells are highly sensitive to xenobiotics. • Expression of genes involved in xenobiotic disposition was measured. • PT cells exhibited the highest similarities with renal tissue.

  5. What Is Typical Is Good : The Influence of Face Typicality on Perceived Trustworthiness

    NARCIS (Netherlands)

    Sofer, Carmel; Dotsch, Ron; Wigboldus, Daniel H J; Todorov, Alexander

    2015-01-01

    The role of face typicality in face recognition is well established, but it is unclear whether face typicality is important for face evaluation. Prior studies have focused mainly on typicality’s influence on attractiveness, although recent studies have cast doubt on its importance for attractiveness

  6. What Is Typical Is Good : The Influence of Face Typicality on Perceived Trustworthiness

    NARCIS (Netherlands)

    Sofer, Carmel; Dotsch, Ron|info:eu-repo/dai/nl/328554197; Wigboldus, Daniel H J; Todorov, Alexander

    2015-01-01

    The role of face typicality in face recognition is well established, but it is unclear whether face typicality is important for face evaluation. Prior studies have focused mainly on typicality’s influence on attractiveness, although recent studies have cast doubt on its importance for attractiveness

  7. Human amniotic fluid stem cells as a model for functional studies of genes involved in human genetic diseases or oncogenesis.

    Science.gov (United States)

    Rosner, Margit; Dolznig, Helmut; Schipany, Katharina; Mikula, Mario; Brandau, Oliver; Hengstschläger, Markus

    2011-09-01

    functions in AFS cells was established. Since AFS cells are not tumorigenic, gene modulations not only allow to investigate the role of endogenous genes involved in human genetic diseases but also may help to reveal putative oncogenic gene functions in different biological models, both in vitro and in vivo. This concept is discussed and a "proof of principle", already obtained via modulating genes involved in the mammalian target of rapamycin (mTOR) pathway in AFS cells, is presented.

  8. Ethnic Differences in the Effect of Parenting on Gang Involvement and Gang Delinquency: A Longitudinal, Hierarchical Linear Modeling Perspective.

    Science.gov (United States)

    Walker-Barnes, Chanequa J.; Mason, Craig A.

    2001-01-01

    Examined relative influence of peer and parenting behavior on changes in adolescent gang involvement and gang-related delinquency among ninth-graders. Found that gang involvement decreased over the school year, with average levels of gang delinquency remaining constant. Gang involvement and gang-related delinquency were most strongly predicted by…

  9. Computational modeling of chemical reactions and interstitial growth and remodeling involving charged solutes and solid-bound molecules.

    Science.gov (United States)

    Ateshian, Gerard A; Nims, Robert J; Maas, Steve; Weiss, Jeffrey A

    2014-10-01

    Mechanobiological processes are rooted in mechanics and chemistry, and such processes may be modeled in a framework that couples their governing equations starting from fundamental principles. In many biological applications, the reactants and products of chemical reactions may be electrically charged, and these charge effects may produce driving forces and constraints that significantly influence outcomes. In this study, a novel formulation and computational implementation are presented for modeling chemical reactions in biological tissues that involve charged solutes and solid-bound molecules within a deformable porous hydrated solid matrix, coupling mechanics with chemistry while accounting for electric charges. The deposition or removal of solid-bound molecules contributes to the growth and remodeling of the solid matrix; in particular, volumetric growth may be driven by Donnan osmotic swelling, resulting from charged molecular species fixed to the solid matrix. This formulation incorporates the state of strain as a state variable in the production rate of chemical reactions, explicitly tying chemistry with mechanics for the purpose of modeling mechanobiology. To achieve these objectives, this treatment identifies the specific theoretical and computational challenges faced in modeling complex systems of interacting neutral and charged constituents while accommodating any number of simultaneous reactions where reactants and products may be modeled explicitly or implicitly. Several finite element verification problems are shown to agree with closed-form analytical solutions. An illustrative tissue engineering analysis demonstrates tissue growth and swelling resulting from the deposition of chondroitin sulfate, a charged solid-bound molecular species. This implementation is released in the open-source program FEBio ( www.febio.org ). The availability of this framework may be particularly beneficial to optimizing tissue engineering culture systems by examining the

  10. Transition from 'model-based' to 'model-free' behavioral control in addiction: Involvement of the orbitofrontal cortex and dorsolateral striatum.

    Science.gov (United States)

    Lucantonio, Federica; Caprioli, Daniele; Schoenbaum, Geoffrey

    2014-01-01

    Cocaine addiction is a complex and multidimensional process involving a number of behavioral and neural forms of plasticity. The behavioral transition from voluntary drug use to compulsive drug taking may be explained at the neural level by drug-induced changes in function or interaction between a flexible planning system, associated with prefrontal cortical regions, and a rigid habit system, associated with the striatum. The dichotomy between these two systems is operationalized in computational theory by positing model-based and model-free learning mechanisms, the former relying on an "internal model" of the environment and the latter on pre-computed or cached values to control behavior. In this review, we will suggest that model-free and model-based learning mechanisms appear to be differentially affected, at least in the case of psychostimulants such as cocaine, with the former being enhanced while the latter are disrupted. As a result, the behavior of long-term drug users becomes less flexible and responsive to the desirability of expected outcomes and more habitual, based on the long history of reinforcement. To support our specific proposal, we will review recent neural and behavioral evidence on the effect of psychostimulant exposure on orbitofrontal and dorsolateral striatum structure and function. This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'.

  11. Lipomatosis of the sciatic nerve: typical and atypical MRI features

    Energy Technology Data Exchange (ETDEWEB)

    Wong, Bernadette Zhi Ying [Mayo Clinic School of Medicine, Rochester, MN (United States); University College London, Royal Free and University College Medical School, London (United Kingdom); Amrami, Kimberly K.; Wenger, Doris E. [Mayo Clinic, Department of Radiology, Rochester, MN (United States); Dyck, P. James B. [Mayo Clinic, Department of Neurology, Rochester, MN (United States); Scheithauer, Bernd W. [Mayo Clinic, Department of Pathology, Rochester, MN (United States); Spinner, Robert J. [Mayo Clinic, Department of Neurologic Surgery, Rochester, MN (United States); Mayo Clinic, Department of Orthopedics, Rochester, MN (United States)

    2006-03-15

    Lipomatosis of nerve, also known as fibrolipomatous hamartoma, is a rare condition of nerve, usually affecting the median nerve. The MRI appearance is characteristic. We describe two cases of lipomatosis of nerve involving the sciatic nerve, an extremely unusual location for this lesion, in patients with sciatic neuropathy. These cases share the typical features previously described in the literature for other nerves, but also contain atypical features not previously highlighted, relating to the variability in distribution and extent of the fatty deposition. Recognition of the MRI appearance of this entity is important in order to avoid unnecessary attempts at surgical resection of this lesion. (orig.)

  12. CAXA制造工程师对典型零件的几种造型方法探讨%Several Modeling Methods of Typical Parts by CAXA Manufacturing Engineer

    Institute of Scientific and Technical Information of China (English)

    王武宾

    2013-01-01

    CAXA manufacturing engineer is a set of CAD / CAM in one of the domestic software, this software has powerful 3D wireframe, surface, solid modeling, efficient and easy to learn, with excellent technology of NC machining programming software, widely used in automobile, machinery and electronics industries. This thesis is about the ashtray of solid modeling and surface modeling method to illustrate the three. This paper is mainly on the parts quick modeling method by CAXA Manufacturing Engineer.%  CAXA制造工程师是集CAD/CAM于一体的国产软件,该软件具有功能强大的三维线架、曲面、实体造型,高效易学,具有卓越工艺性的数控加工编程软件,广泛应用于汽车、机械电子等行业。本论文将就烟灰缸的实体造型及上曲面的三种造型方法加以说明。本文主要讲解用CAXA制造工程师实现零件的快速造型方法。

  13. Typical Women Figures in Hemingway's Fictional World

    Institute of Scientific and Technical Information of China (English)

    杨春会; 范璐

    2008-01-01

    Ernest Hemingway is widely regarded as a giant figure in American literature, but meantime he is often criticized for his prejudice against women. However, whether Ernest Hemingway is a misogynist writer or not, I believe is largely depended on readers' comprehension of his works. This paper launched an interesting study on typical women characters in Hemingway's fictional world. The study also reveals that fact that far from being a misogynist writer, Hemingway shows great concern to women as a group. Not only did he own strong insight on women but also expressed his sympathy towards women.

  14. Hail damage to typical aircraft surfaces.

    Science.gov (United States)

    Hayduk, R. J.

    1972-01-01

    Severe structural damage can occur when aircraft collide with hailstones. Consequently, methods of predicting hail damage to airplane surfaces are needed by the aircraft designer. This paper describes an analytical method of predicting the dent depth and final deformed shape for simple structural components impacted by hailstones. The solution was accomplished by adapting the DEPROSS computer program to the problem of normal impact of hail on flat metallic sheets and spherical metallic caps. Experimental data and analytical predictions are presented for hail damage to typical aircraft surfaces along with a description of the hail gun and hail simulation technique used in the experimental study.

  15. A Psychoanalytic Approach to Typical American

    Institute of Scientific and Technical Information of China (English)

    赵磊

    2015-01-01

    Typical American is the representative work of Gish Jen, a famous Chinese American woman writer. This novel is based on the three youth, Ralph, Theresa, and Helen who came to America to study and then became American citizens. This thesis tries to analyze the special psychological state of them from the perspective of psychoanalysis according to Freud 's psychoanalytic theo-ry. Through the writing of this thesis, the author regards that their specific psychoanalytic state is a group features. To learn these special features can help us have a good understanding of people coming from different cultural backgrounds.

  16. Artificial bias typically neglected in comparisons of uncertain atmospheric data

    Science.gov (United States)

    Pitkänen, Mikko R. A.; Mikkonen, Santtu; Lehtinen, Kari E. J.; Lipponen, Antti; Arola, Antti

    2016-09-01

    Publications in atmospheric sciences typically neglect biases caused by regression dilution (bias of the ordinary least squares line fitting) and regression to the mean (RTM) in comparisons of uncertain data. We use synthetic observations mimicking real atmospheric data to demonstrate how the biases arise from random data uncertainties of measurements, model output, or satellite retrieval products. Further, we provide examples of typical methods of data comparisons that have a tendency to pronounce the biases. The results show, that data uncertainties can significantly bias data comparisons due to regression dilution and RTM, a fact that is known in statistics but disregarded in atmospheric sciences. Thus, we argue that often these biases are widely regarded as measurement or modeling errors, for instance, while they in fact are artificial. It is essential that atmospheric and geoscience communities become aware of and consider these features in research.

  17. Platelets can neutralize hydrogen peroxide in an acute toxicity model with cells involved in granulation tissue formation.

    Science.gov (United States)

    Kandler, Barbara; Maitz, Philipp; Fischer, Michael B; Watzek, Georg; Gruber, Reinhard

    2005-04-01

    Platelets play a key role in the replacement of the blood clot with granulation tissue during the early steps of bone regeneration. We hypothesized that activated platelets can neutralize locally produced reactive oxygen species, thereby protecting cells involved in granulation tissue formation. The potential of platelet-released supernatant (PRS) to neutralize hydrogen peroxide (H(2)O(2)) was tested in an acute toxicity model with osteogenic, inflammatory, and endothelial cells. In the human fetal osteoblastic cell line 1.19 (hFOB), considerable morphological changes, cell shedding, and dysfunction of the respiratory chain were observed when cells were exposed to 3 mM H(2)O(2). Caspase-3 and poly-(ADP-ribose)-polymerase were not activated, suggesting that cell death occurred by necrosis. Preincubation of osteogenic cells, leukocytes, or endothelial cells with PRS decreased the acute toxicity of H(2)O(2). The capacity of platelets to release H(2)O(2)-detoxifying activity was retained for up to 72 h. Aminotriazole, an inhibitor of catalase, decreased the cytoprotective activity of PRS, whereas blocking of glutathione peroxidase by mercaptosuccinate had no effect. These results suggest that platelet-released catalase can rapidly neutralize cytotoxic amounts of H(2)O(2), a process that may play a role during the early stages of bone regeneration.

  18. Establishment of an ovarian metastasis model and possible involvement of E-cadherin down-regulation in the metastasis.

    Science.gov (United States)

    Kuwabara, Yoshiko; Yamada, Taketo; Yamazaki, Ken; Du, Wen-Lin; Banno, Kouji; Aoki, Daisuke; Sakamoto, Michiie

    2008-10-01

    Clinical observations of cases of ovarian metastasis suggest that there may be a unique mechanism underlying ovarian-specific metastasis. This study was undertaken to establish an in vivo model of metastasis to the ovary, and to investigate the mechanism of ovarian-specific metastasis. We examined the capacity for ovarian metastasis in eight different human carcinoma cell lines by implantation in female NOD/SCID mice transvenously and intraperitoneally. By transvenous inoculation, only RERF-LC-AI, a poorly differentiated carcinoma cell line, frequently demonstrated ovarian metastasis. By intraperitoneal inoculation, four of the eight cell lines (HGC27, MKN-45, KATO-III, and RERF-LC-AI) metastasized to the ovary. We compared E-cadherin expression among ovarian metastatic cell lines and others. All of these four ovarian metastatic cell lines and HSKTC, a Krukenberg tumor cell line, showed E-cadherin down-regulation and others did not. E-cadherin was then forcibly expressed in RERF-LC-AI, and inhibited ovarian metastasis completely. The capacity for metastasizing to the other organs was not affected by E-cadherin expression. We also performed histological investigation of clinical ovarian-metastatic tumor cases. About half of all ovarian-metastatic tumor cases showed loss or reduction of E-cadherin expression. These data suggest that E-cadherin down-regulation may be involved in ovarian-specific metastasis.

  19. Homology modeling and identification of amino acids involved in the catalytic process of Mycobacterium tuberculosis serine acetyltransferase.

    Science.gov (United States)

    Qiu, Juanjuan; Zang, Shizhu; Ma, Yufang; Owusu, Lawrence; Zhou, Lei; Jiang, Tao; Xin, Yi

    2017-03-01

    Serine acetyltransferase (CysE) belongs to the hexapeptide acetyltransferase family and is involved in the biosynthesis of L‑cysteine in microorganisms. Mycobacterium tuberculosis CysE is regarded as a potential target for anti‑tuberculosis (TB) drugs; however, the structure and active sites of M. tuberculosis CysE remain unknown. The present study aimed to predict the secondary structure and to construct a 3D model for M. tuberculosis CysE using bioinformatics analysis. To determine the essential amino acids that are associated with CysE enzymatic activity, amino acid sequences from several microorganisms were compared, and a consensus sequence was identified. Subsequently, site‑directed mutagenesis was used to generate mutant M. tuberculosis CysE proteins. Enzyme assays demonstrated that D67A, H82A and H117A mutants abolished ~75% activity of M. tuberculosis CysE. Prediction of the protein structure and identification of the active amino acids for M. tuberculosis CysE is essential for designing inhibitors, which may aid the discovery of effective anti‑TB drugs.

  20. An approach to assess NEE and C-costs associated with an energy-crop production at different erosion-induced transient states in a typical Northeastern Germany landscape using process-based agroecosystem modeling

    Science.gov (United States)

    Chatskikh, D.; Nendel, C.; Hagemann, U.; Specka, X.; Augustin, J.; Sommer, M.; Van Oost, K.

    2012-04-01

    Net Ecosystem Exchange (NEE) and C-costs associated with energy-crop production systems which are outside of NEE must be determined to suggest optimal mitigation options. In theory, NEE can be positive, if SOC is building up, neutral or balanced, with no change in SOC, or negative, if SOC is lost as a result of a soil degradation processes. Unclearness in complex multiscale interactions between different processes in the landscape in combination with a well-known wide range of uncertainties around NEE estimations makes these estimations for landscape scale scarce. In this study we used a process-based modeling to assess C-costs associated with soil erosion, assessing NEE at different erosion-induced transient states in the experiment settled Northeastern Germany (near Dedelow) in a representative section of younger landscape of hummocky ground moraine (CarboZALF-D). We used Monica, a soil-crop-atmosphere model, which is well-validated for various crops and soil in Germany. In the model, NEE (=-NEP) refer to NPP minus C losses in heterotrophic respiration, while NBE (=-NBP) refers to the change in SOC stocks after C losses due to regular (e.g. soil erosion) or occasional (e.g. harvest) disturbances. In this study we applied Monica to analyze relationships between past geomorphic processes, landscape position, crop growth and NEE. In this study we were interested in general trends and associated agroecosystem properties, rather than on magnitude of the fluxes. The results showed that past soil redistribution affected NEE at both positions, while the Monica-based scenarios in combination with data-based interpolations helped to interpret the NEE budgets. The model captured the magnitude of differences in the daily NEE values, but also the differences in an accumulated NEE fluxes between different erosion-induced transient states. Thus for both eroded and deposited positions NEE was negative. However absolute values of NEE were smaller for the deposited site compare to

  1. CYBERCITY:CONCEPTION,TECHNICAL SUPPORTS AND TYPICAL APPLICATIONS

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    In this paper,the concepts about the CyberCity and the corresponding technique supports and typical applications are introduced.As the pilot projects,the applications of CCGIS software in CyberShenzhen and CyberShanghai are also presented.At last,some of key technologies such as the reconstruction of three dimensional city model,vast amount of data integration and its real time application of 3D animation are discussed.

  2. On Typicality in Nonequilibrium Steady States

    Science.gov (United States)

    Evans, Denis J.; Williams, Stephen R.; Searles, Debra J.; Rondoni, Lamberto

    2016-08-01

    From the statistical mechanical viewpoint, relaxation of macroscopic systems and response theory rest on a notion of typicality, according to which the behavior of single macroscopic objects is given by appropriate ensembles: ensemble averages of observable quantities represent the measurements performed on single objects, because " almost all" objects share the same fate. In the case of non-dissipative dynamics and relaxation toward equilibrium states, " almost all" is referred to invariant probability distributions that are absolutely continuous with respect to the Lebesgue measure. In other words, the collection of initial micro-states (single systems) that do not follow the ensemble is supposed to constitute a set of vanishing, phase space volume. This approach is problematic in the case of dissipative dynamics and relaxation to nonequilibrium steady states, because the relevant invariant distributions attribute probability 1 to sets of zero volume, while evolution commonly begins in equilibrium states, i.e., in sets of full phase space volume. We consider the relaxation of classical, thermostatted particle systems to nonequilibrium steady states. We show that the dynamical condition known as Ω T-mixing is necessary and sufficient for relaxation of ensemble averages to steady state values. Moreover, we find that the condition known as weak T-mixing applied to smooth observables is sufficient for ensemble relaxation to be independent of the initial ensemble. Lastly, we show that weak T-mixing provides a notion of typicality for dissipative dynamics that is based on the (non-invariant) Lebesgue measure, and that we call physical ergodicity.

  3. Joint involvement in Ochronosis

    OpenAIRE

    Biehl, Christoph; Thormann, U.; Madera, N.; Heiß, C

    2016-01-01

    Introduction: Ochronosis is a metabolic disorder that is usually associated with the typical brown-black colored urine and retention of phenol complexes in sclera and skin. Kidney and heart are also checked, the disease can also cause damage in these organs. The disease is less associated with degenerative changes in the joints of the limbs and the spine. Methods: We report on the progress of a patient with documented family history on alcaptonuria and joint involvement. In the age of 69 ...

  4. Typically Female Features in Hungarian Shopping Tourism

    Directory of Open Access Journals (Sweden)

    Gábor Michalkó

    2006-06-01

    Full Text Available Although shopping has been long acknowledged as a major tourist activity, the extent and characteristics of shopping tourism have only recently become the subject of academic research and discussion. As a contribution to this field of knowledge, the paper presents the characteristics of shopping tourism in Hungary, and discusses the typically female features of outbound Hungarian shopping tourism. The research is based on a survey of 2473 Hungarian tourists carried out in 2005. As the findings of the study indicate, while female respondents were altogether more likely to be involved in tourist shopping than male travellers, no significant difference was experienced between the genders concerning the share of shopping expenses compared to their total travel budget. In their shopping behaviour, women were typically affected by price levels, and they proved to be both more selfish and more altruistic than men by purchasing more products for themselves and for their family members. The most significant differences between men and women were found in their product preferences as female tourists were more likely to purchase typically feminine goods such as clothes, shoes, bags and accessories, in the timing of shopping activities while abroad, and in the information sources used by tourists, since interpersonal influences such as friends’, guides’ and fellow travellers’ recommendations played a higher role in female travellers’ decisions.

  5. GSK-3β may be involved in hippocampal mossy fiber sprouting in the pentylenetetrazole-kindling model.

    Science.gov (United States)

    Huang, Wen-Jiao; Tian, Fa-Fa; Chen, Jin-Mei; Guo, Ting-Hui; Ma, Yun-Feng; Fang, Jia; Dang, Jing; Song, Ming-Yu

    2013-11-01

    Mossy fiber sprouting (MFS) is a pathological phenomenon that is commonly observed in temporal lobe epilepsy (TLE). However, the molecular mechanisms underlying MFS remain unclear. It has been demonstrated that the tau protein is important in the progression of MFS by the regulation of microtubule dynamics and axonal transport, with all of these functions of tau modulated by its site-specific phosphorylation. Glycogen synthase kinase-3β (GSK-3β) is an active kinase that regulates the phosphorylation of tau protein. Therefore, it was hypothesized that GSK-3β contributes to MFS by phosphorylating tau protein. The aim of the present study was to determine the expression and activity of GSK-3β at different regions in the rat hippocampus during the pentylenetetrazole (PTZ)-kindling process in order to demonstrate the possible correlation with MFS, and to investigate the involvement of GSK-3β in epileptogenesis. Male Sprague-Dawley rats (n=180) were randomly divided into the control and PTZ-treated groups. The chronic epileptic model was established by intraperitoneal injection of PTZ and the hippocampus was observed for the presence of MFS using Timm staining. GSK-3β mRNA, protein and activity were analyzed in various regions of the hippocampus using in situ hybridization, immunohistochemistry and immunoprecipitation followed by a kinase assay and liquid scintillation counting, respectively. MFS was observed prior to kindling and an increased distribution of Timm granules were observed in the CA3 region of the PTZ-treated rats; however, this was not demonstrated in the supragranular layer of the dentate gyrus. The expression of GSK-3β mRNA and protein, as well as the GSK-3β activity, increased significantly from 3 days to 4 weeks in the PTZ group, and this was correlated with the progression of MFS in the CA3 area. In addition, it was demonstrated that MFS did not result from TLE. GSK-3β may therefore be involved in the progression of MFS and is important in

  6. Analysis on typical gas adsorption models for shale gas or coalbed methane%页岩气煤层气典型气体吸附模型分析

    Institute of Scientific and Technical Information of China (English)

    刘明进; 李晨宇

    2015-01-01

    对大量实验数据描绘出的气体吸附等温线分析认为,Langmuir 方程形式简单,可以计算气体的吸附气量,但是对固体表面均一性的假设和单分子层吸附使其应用局限;BET 方程是计算比表面积的常用模型,但同样需假设固体表面均一性;BJH 模型较好地反映毛细凝聚现象和滞后环,但由于毛细凝聚只能在中孔中出现,不能解释存在微孔的样品;DR/DA 方程只能在地压条件下对微孔吸附进行描述。%After analyzing the gas isothermal adsorption curves described by a large number of experimental data,some conclusions were shown as follows:(1)although Langmuir equation has simple form and may calculate gas adsorption a-mount,the application of the equation is limited by the assumption of uniform solid surface and single layer adsorption;(2) BET equation is a common model for calculating specific surface area,but requires the assumption of uniform solid surface;(3)although BJH model can better reflect the phenomenon of capillary condensation and hysteresis loop,it can not explain the micro porous sample because the phenomenon of capillary condensation only exists in the medium pore;(4)DR/DA model can only describe the gas adsorption of micro pore under the low -pressure condition.The results have great guiding significance to study on the gas adsorption /desorption mechanisms.

  7. Typical object velocity influences motion extrapolation.

    Science.gov (United States)

    Makin, Alexis D J; Stewart, Andrew J; Poliakoff, Ellen

    2009-02-01

    Previous work indicates that extrapolation of object motion during occlusion is affected by the velocity of the immediately preceding trial. Here we ask whether longer-term velocity representations can also influence motion extrapolation. Red, blue or green targets disappeared behind an occluder. Participants pressed a button when they thought the target had reached the other side. Red targets were slower (10-20 deg/s), blue targets moved at medium velocities (14-26 deg/s) and green targets were faster (20-30 deg/s). We compared responses on a subset of red and green trials which always travelled at 20 deg/s. Although trial velocities were identical, participants responded as if the green targets moved faster (M = 22.64 deg/s) then the red targets (M = 19.72 deg/s). This indicates that motion extrapolation is affected by longer-term information about the typical velocity of different categories of stimuli.

  8. Typicity in Potato: Characterization of Geographic Origin

    Directory of Open Access Journals (Sweden)

    Marco Manzelli

    2010-03-01

    Full Text Available A two-year study was carried out in three regions of Italy and the crop performance and the chemical composition of tubers of three typical potato varieties evaluated. Carbon and nitrogen tuber content was determined by means of an elemental analyzer and the other mineral elements by means of a spectrometer. The same determinations were performed on soil samples taken from experimental areas. The Principal Component Analysis, applied to the results of mineral element tuber analysis, permitted the classification of all potato tuber samples according to their geographic origin. Only a partial discrimination was obtained in function of potato varieties. Some correlations between mineral content in the tubers and in the soil were also detected. Analytical and statistical methods proved to be useful in verifying the authenticity of guaranteed geographical food denominations.

  9. Manipulating decision making of typical agents

    CERN Document Server

    Yukalov, V I

    2014-01-01

    We investigate how the choice of decision makers can be varied under the presence of risk and uncertainty. Our analysis is based on the approach we have previously applied to individual decision makers, which we now generalize to the case of decision makers that are members of a society. The approach employs the mathematical techniques that are common in quantum theory, justifying our naming as Quantum Decision Theory. However, we do not assume that decision makers are quantum objects. The techniques of quantum theory are needed only for defining the prospect probabilities taking into account such hidden variables as behavioral biases and other subconscious feelings. The approach describes an agent's choice as a probabilistic event occurring with a probability that is the sum of a utility factor and of an attraction factor. The attraction factor embodies subjective and unconscious dimensions in the mind of the decision maker. We show that the typical aggregate amplitude of the attraction factor is $1/4$, and ...

  10. Iron absorption from typical Latin American diets.

    Science.gov (United States)

    Acosta, A; Amar, M; Cornbluth-Szarfarc, S C; Dillman, E; Fosil, M; Biachi, R G; Grebe, G; Hertrampf, E; Kremenchuzky, S; Layrisse, M

    1984-06-01

    The availability and daily absorption of iron was determined by the extrinsic label method in typical lower middle to lower class diets consumed in regions of Argentina, Brazil, Chile, Mexico, Peru, and Venezuela. Differences in iron absorption from meals up to 7-fold, could be attributed to the varying contents of absorption enhancers, eg, in meat, and of inhibitors in tea, vegetables, and wheat or maize bread. The total iron available in the diets from four countries did not meet the physiological requirements for normal subjects but deficient subjects fulfilled their requirements absorbing from 1.0 to 2.1 mg/day. In five diets heme iron (6 to 24% of the total) provided 34 to 73% of the iron absorbed. These data suggest that such absorption and utilization studies may be used to correlate the prevalence of iron deficiency in a population with certain diets and to guide fortification programs.

  11. Applying Pleck's Model of Paternal Involvement to the Study of Preschool Attachment Quality: A Proof of Concept Study

    Science.gov (United States)

    Kennedy, Mark; Betts, Lucy; Dunn, Thomas; Sonuga-Barke, Edmund; Underwood, Jean

    2015-01-01

    Recent re-conceptualisation of paternal involvement (Pleck, J. H. (2010). Paternal involvement: Revised conceptualization and theoretical linkages with child outcomes. In M. Lamb (Ed.), "The role of the father in child development" (5th ed., pp. 67-107). London: Wiley), while proving fruitful, has yet to be applied to investigations into…

  12. Autophagy and cathepsin L are involved in the antinociceptive effect of DMBC in a mouse acetic acid-writhing model

    Institute of Scientific and Technical Information of China (English)

    Wei-wei GU; Gui-zhen AO; Yong-ming ZHU; Shi-chang SUN; Qiang ZHOU; Jia-hong FAN; Katunuma NOBUHIKO

    2013-01-01

    Aim:2-(3',5'-Dimethoxybenzylidene) cyclopentanone (DMBC) is a novel synthetic compound with antinociceptive activities.The aim of this study was to investigate the roles of the autophagic-lysosomal pathway in the antinociceptive effect of DMBC in a mouse acetic acid-writhing model.Methods:Mouse acetic acid-writhing test and hotplate test were used to assess the antinociceptive effects of DMBC,3-MA (autophagy inhibitor) and Clik148 (cathepsin L inhibitor).The drugs were administered peripherally (ip) or centrally (icv).Results:Peripheral administration of 3-MA (7.5-30 mg/kg) or Clik148 (10-80 mg/kg) produced potent antinociceptive effect in acetic acid-writhing test.Central administration of 3-MA or Clik148 (12.5-50 nmol/L) produced comparable antinociceptive effect in acetic acid-writhing test.Peripheral administration of DMBC (25-50 mg/kg) produced potent antinociceptive effects in both acetic acidwrithing and hotplate tests.Furthermore,the antinociceptive effect produced by peripheral administration of DMBC (50 mg/kg) in acetic acid-writhing test was antagonized by low doses of 3-MA (3.75 mg/kg) or Clik148 (20 mg/kg) peripherally administered,but was not affected by 3-MA or Clik148 (25 nmol/L) centrally administered.Conclusion:Activation of central autophagy and cathepsin L is involved in nociception in mice,whereas peripheral autophagy and cathepsin L contributes,at least in part,to the antinociceptive effect of DMBC in mice.

  13. Head and cervical spine posture in behaving rats: implications for modeling human conditions involving the head and cervical spine.

    Science.gov (United States)

    Griffin, C; Choong, W Y; Teh, W; Buxton, A J; Bolton, P S

    2015-02-01

    The aim of this study was to define the temporal and spatial (postural) characteristics of the head and cervical vertebral column (spine) of behaving rats in order to better understand their suitability as a model to study human conditions involving the head and neck. Time spent in each of four behavioral postures was determined from video tape recordings of rats (n = 10) in the absence and presence of an intruder rat. Plain film radiographic examination of a subset of these rats (n = 5) in each of these postures allowed measurement of head and cervical vertebral column positions adopted by the rats. When single they were quadruped or crouched most (∼80%) of the time and bipedal either supported or free standing for only ∼10% of the time. The introduction of an intruder significantly (P cervical spine was orientated (median, 25-75 percentile) near vertical (18.8°, 4.2°-30.9°) when quadruped, crouched (15.4°, 7.6°-69.3°) and bipedal supported (10.5°, 4.8°-22.6°) but tended to be less vertical oriented when bipedal free standing (25.9°, 7.7°-39.3°). The range of head positions relative to the cervical spine was largest when crouched (73.4°) and smallest when erect free standing (17.7°). This study indicates that, like humans, rats have near vertical orientated cervical vertebral columns but, in contrast to humans, they displace their head in space by movements at both the cervico-thoracic junction and the cranio-cervical regions. © 2014 Wiley Periodicals, Inc.

  14. The Transition to Kindergarten for Typically Developing Children: A Survey of School Psychologists' Involvement

    Science.gov (United States)

    McIntyre, Laura Lee; Eckert, Tanya L.; Arbolino, Lauren A.; DiGennaro Reed, Florence D.; Fiese, Barbara H.

    2014-01-01

    Research suggests that a large percentage of kindergarten children do not successfully transition to school (Rimm-Kaufman et al. 2000). As a result, a number of school transition initiatives have been developed by educators and policy makers to address the difficulties young children may experience upon kindergarten entry. Despite this attention,…

  15. 江西持续性暴雨的典型大尺度环流模型%The typical large scale circulation model of persistent heavy rain in Jiangxi

    Institute of Scientific and Technical Information of China (English)

    邹海波; 单九生; 吴珊珊; 尹洁

    2013-01-01

      利用1961—2010年共50 a的500 hPa欧亚地区历史天气图资料对江西省74次持续性暴雨天气过程的大尺度环流形势进行分析,并建立了江西省持续性暴雨天气的大尺度环流模型。结果表明,该模型中,欧亚中高纬的长波槽脊呈双阻塞高压型,两个阻塞高压分别位于乌拉尔山西侧和鄂霍茨克海西侧;我国东北地区有一低涡,且从该低涡中心至江西附近地区有一深厚低压槽(华北槽);西太平洋副热带高压位于低纬西太平洋地区,其脊线位于20 N附近,西脊点位于110 E附近,副热带高压北侧的584 dagpm线位置(115 E的纬度)位于27 N附近;华北槽后的干冷空气与副热带高压西北侧的暖湿气流持续交汇于江西地区,为持续性暴雨提供了有利于水汽输送和辐合抬升条件。500 hPa的历史天气图和NCEP资料均显示,该大尺度环流模型具有较好的普适性。%With the 500 hPa daily weather images over Eurasian region from 1961 to 2010, the large scale weather patterns of 74 persistent heavy rain cases in Jiangxi were analyzed. Based on the analysis results, the large scale circulation model for Jiangxi persistent heavy rain was established. In this model, two blocking high located in the west side of Ural Mountains and the west side of the Okhotsk Sea respectively. There was a low vortex in the Northeast China, and a deep trough (North China trough) lay from the center of the low vortex to the Jiangxi area. The west Pacific subtropical high located over western Pacific region at low latitude, its ridge line lied near 20° N, west ridge point situated near 110°E and“584”line was at north side of the subtropical high loacated near 27°N. The cold dry air at rear of North China trough con-tinuously converged with the warm wet air in the northwest of West Pacific subtropical high over Jiangxi, which provided the favourable condi-tions of water vapor transportation

  16. Occurrence Grade Index Model of Dynamic Early Warning for Wheat Powdery Mildew in Typical Region%典型区域小麦白粉病发生气象等级动态预警模型

    Institute of Scientific and Technical Information of China (English)

    张蕾; 霍治国; 姜燕; 王丽

    2015-01-01

    通过分析历年小麦白粉病病情指数随时间的变化特点,将河南省南阳市的病情资料统一内插处理为以周为时间尺度的资料序列,将河北省正定县、辛集市、馆陶县和磁县的资料统一内插处理为以候为时间尺度的资料序列。利用2001-2010年小麦白粉病观测资料及相应时段的气象资料,采用秩相关分析和通径分析方法筛选分析影响白粉病发生等级的关键因子及因子贡献,基于Bayes准则建立南阳市和河北4县的区域小麦白粉病等级预测模型。结果表明:小麦白粉病病情指数随时间的变化符合Logistic曲线特点,内插处理效果较好;影响南阳市小麦白粉病发生的关键因子是前1周的病害发生等级、前1周至当周的相对湿度、前2周至当周的日照时数和前3周至当周的降雨系数,影响河北4县的关键因子是前1候的病害发生等级、前3候至当候的平均温度、前3候至当候的降水量和前3候至当候的降雨系数。利用指标模型对南阳市和河北4县病害发生等级进行检验,达到完全“一致”的准确率超过85%,“基本一致”的准确率超过90%,说明模型预警效果较好,可以用于相应区域小麦白粉病短时临近预报。%As being prone to wheat powdery mildew, Henan and Hebei province are affected severely by wheat powdery mildew. Through analysis on variable characteristic of disease index for winter powdery mildew, the disease index data in Nanyang city was interpolated at week scale and interpolated at pentad scale in Zhengding, Xinji, Guantao and Cixian. Based on disease observation data for wheat powdery mildew from 2001 to 2010 and daily meteorological data for corresponding period, the key factors and key period affecting occurrence grade for wheat powdery mildew were selected using rank correlation analysis and path analysis. Occurrence grade index model of dynamic warning for wheat powdery mildew

  17. ONE TYPICAL EXTREMUM IN ELECTRICAL PROBLEMS

    Directory of Open Access Journals (Sweden)

    V. I. Goroshko

    2014-01-01

    Full Text Available The aim of this work is to attract attention of teachers, scientific personnel, engineers and students to one peculiarity of extremum seeking in different electrical problems. This feature lies in the fact that in many parts of electrical engineering extremum seeking comes to analysis one and the same mathematical structure (T-structure, but differences lie only in many symbols (designation.In one problems this structure appear in finale, the most simple form, but in others – T-structure is “veiled”, and as a rule  we need  elementary algebraic transformation to detect it.Taking into account high frequency of this structure appearing in electrical problems, in the first part of article the authors  carried out the investigation of extremum characteristics of T-structure and show the results in easy algorithms. To determine the typical T-structure there were taken five problems-examples for extremum seeking  from different parts of electrical engineering. The first and the second examples belong to the theory of electrical circuits.In the first example the problem of maximum active load power obtaining was considered, in the second we see the solution of problem for inductive coupled circuit adjustment in order to obtain the hump current. In the third example the band active filter, built on operating amplifier, is analyzed. According to these methods, taken in the first part of article, the frequency is determined, on which amplifier provides maximum  amplification factor. The forth example deals with analysis of efficiency of transformer. According to algorithm, the optimal efficiency of transformer’s load and also equation for its maximum was determined in this article. In the fifth example the mechanical characteristics of induction motor is analyzed. It is indicated how, on the basis of algorithms article, to obtain equations for critical slip and motor moment, and also the simple development of formula Klossa.The methods of

  18. Dealing with typical values via Atanassov's intuitionistic fuzzy sets

    Science.gov (United States)

    Szmidt, Eulalia; Kacprzyk, Janusz

    2010-07-01

    This paper is an improved and extended version of our previous work2 on typicality in terms of Atanassov's intuitionistic fuzzy sets (to be called A-IFSs, for short)3. We follow the line of reasoning known from psychological and cognitive sciences, in particular from linguistic experiments, and verify how those results work in the case of classification - a typical problem in computer science, decision sciences, etc. Our considerations concentrate on a typical example discussed in cognitive sciences - we investigate to which extent a linguistic representation in a psychological space (we start from nominal data - names are assigned to objects as labels) succeeds in predicting categories via A-IFSs. First, we consider a model of categories with a geometrical centroid model in which the similarity is defined in terms of a distance to centroids. Next, we verify if the extreme ideals, which are important in cognitive processes when categories are learnt in the presence of the alternative (contrast) category, give comparative results. Finally, we discuss if the 'reachable extreme ideals' and 'dominating frequency centres' give comparative results. We show that A-IFSs make it possible to reflect a positive and negative information via the concept of membership and non-membership. Although the paper presents ongoing research, the results obtained are promising and point out the usefulness and strength of A-IFSs as a tool to account for more aspects of vague data and information. Based on 'On Some Typical Values for A-IFS', by E. Szmidt and J. Kacprzyk which appeared in the Proceedings of the 4th International IEEE Conference on Intelligent Systems IS'08, pp. 13-2-13-7. There is currently a discussion on the appropriateness of the name IFS introduced by Dubois et al. (2005), and also Atanassov's (2005) response. This is, however, beyond the scope of this paper which will not be dealing with this issue.

  19. Assessment on drought risk of typical wheat in China based on EPIC model%基于EPIC模型的中国典型小麦干旱致灾风险评价

    Institute of Scientific and Technical Information of China (English)

    王志强; 何飞; 栗健; 廖永丰

    2012-01-01

    运用EPIC( Environmental Policy Integrated Climate)农作物生长模型模拟了1966- 2005年中国典型小麦生长过程,构建了基于水分胁迫的小麦干旱致灾强度指数,对中国小麦干旱致灾强度和风险的时空分布规律进行了定量评价分析.结果表明:小麦干旱致灾强度呈现出从西北干旱区向东南湿润区递减的趋势,且春小麦分布区旱灾致灾强度高于冬小麦分布区;中国农牧交错带是小麦干旱致灾强度较强且波动较大的区域,也是小麦干旱致灾风险较高的区域;1966 - 2005年春小麦区干旱致灾强度呈现下降趋势,而冬小麦区呈现普遍上升趋势,其中北部和黄淮冬麦上升趋势最为明显.%With global climate change and global warming,the frequency and intensity of drought event and loss is increased. This paper simulated the growth process of wheat in China from 1966 to 2005 using EPIC ( Environmental Policy Integrated Climate) crop model,developed the drought hazard intensity index based on crop water stress index and quantitatively analyzed the tempo-spatial distribution regularity of wheat drought hazard intensity and drought hazard risk. The results is as follows: Fistly,drought hazard intensity of wheat caused by drought was decreased from the arid region of northwest China to the humid region of southeast China,and drought hazard intensity of spring wheat area was higher than winter wheat area; Secondly,the annual variation and intensity of wheat drought hazard intensity had an abnormal high-value zone,and its space range agreed with the Fanning-Pastoral Zone and ecological vulnerable zone of China,which is the high-value zone of the wheat drought hazard risk; Finally,in 1966 to 2005,drought hazard intensity of spring wheat area was decreased,while drought intensity of the winter wheat area was increased,and the North winter wheat area and the winter wheat area of Huang-River and Huai-River demonstrated a distinguished uptrend in all

  20. 典型蓄电池的建模与荷电状态估算的对比研究%Comparison study on model and state of charge estimation of typical battery

    Institute of Scientific and Technical Information of China (English)

    吴红斌; 顾缃; 赵波; 朱承治

    2014-01-01

    研究不同蓄电池荷电状态(state of charge, SOC)的变化特征有助于在实际应用过程中对蓄电池类型进行选择。基于铅酸电池、磷酸铁锂电池、全钒液流电池3种典型蓄电池模型,采用电池容量修正过的改进安时计量法和改进安时-卡尔曼预测法( Ah-Kal法),对各电池在不同充放电模式下,用MATLAB软件编程得到两种估算方法下的SOC变化曲线。通过SOC对比曲线可以发现铅酸电池的自放电较严重,循环寿命短;磷酸铁锂电池可迅速提供大功率;而全钒液流电池适合作为长期大容量储能支持。同时,改进安时计量法和Ah-Kal的估算结果基本相同,验证了Ah-Kal法的正确性。%It is helpful to make the reasonable choice on types of battery in actual application through studying on state of charge (SOC) of the different batteries.Based on the models of Lead-acid battery, LiFePO4Li-ion battery and Vanadium Redox Flow battery(VRB), the SOC of each battery was estimated through the improved Ah count-ing method and the method of combined improved Ah counting-Kalman filtering(Ah-kal method).Under the differ-ent charging or discharging modes, it obtained the curves of SOC with MATLAB software.It can be found that the Lead-acid battery has the serious self-discharge and short cycle life, the LiFePO4Li-ion battery could supply rapidly high power, and VRB has the large-capacity energy storage support for long-term.With the simulation results, it validates that the improved Ah counting method and Ah-Kal method have almost equal result .And it verifies the correctness of the Ah-Kal method.

  1. Antinociceptive effects of maprotiline in a rat model of peripheral neuropathic pain: possible involvement of opioid system

    Directory of Open Access Journals (Sweden)

    Hamid Reza Banafshe

    2015-08-01

    Conclusion: Our results suggest that maprotiline can be considered a potential therapeutic for the treatment of neuropathic pain, and the opioid system may be involved in the antihyperalgesic effects of maprotiline.

  2. Parental involvement with the criminal justice system and the effects on their children: a collaborative model for researching vulnerable families.

    Science.gov (United States)

    Akesson, Bree; Smyth, J McGregor; Mandell, Donald J; Doan, Thao; Donina, Katerina; Hoven, Christina W

    2012-01-01

    Despite the existing body of research examining the effects of imprisonment on incarcerated adults, as of yet, there is no solid empirical evidence for understanding the effects of parental involvement with the criminal justice system involvement (CJSI) on children and families. Accordingly, Columbia University-New York State's Child Psychiatric Epidemiology Group (CPEG), supported by a strong collaboration with The Bronx Defenders, a holistic public defender providing free legal representation, is conducting a longitudinal study examining the effects of parental involvement with the criminal justice system on this population. The study aims to understand, over time, the impact of parental CJSI on their children's mental health, including the effects of the collateral legal damage of CJSI (such as eviction and deportation), substance use, the development of risky behaviors leading to the child's potential involvement with the criminal justice system, as well as protective factors and identification of potential intervention points, which has the ability to inform public policy.

  3. [Typical problems in pediatric emergencies: Possible solutions].

    Science.gov (United States)

    Heimberg, E; Heinzel, O; Hoffmann, F

    2015-06-01

    Pediatric emergencies are rare and challenging for health care providers, parents, and patients. The purpose of this article is to highlight typical difficulties in the treatment of pediatric patients and to discuss potential solutions. This article is based on a selective literature search using PubMed and the experience of the authors in the field of simulation and pediatric emergencies. Inexperience with pediatric emergencies, uncertainty in technical skills, in the usage of pediatric equipment and in medication dosage as well as parental presence foster the perception of stress and potentially compromise the success of patient care. Beside implementation of simplified technical skill devices (e.g., intraosseous vascular access system, supraglottic airway devices, and alternative approaches for drug administration), there have been many efforts in recent years to improve patient safety. Tools for estimating body weight and precalculated drug-dosing charts have been implemented as well as standardized courses for guidelines, technical skills, and team-related skills have been established. To improve patient safety, regular training and implementation of a sustainable safety culture are mandatory.

  4. Creating Learning at Conferences Through Participant Involvement

    DEFF Research Database (Denmark)

    Ravn, Ib; Elsborg, Steen

    in Denmark to introduce a variety of simple learning techniques related to the design principles at thirty real conferences of some 100-200 participants each. We present twelve of these techniques and the data evaluating them and conclude that by spending a fraction of the time at a conference on involving......The typical conference is brimming with PowerPoint presentations that leave very little time for participant involvement. Students of learning have long abandoned the transfer model that underlies this massive show of one-way communication. We propose an alternative theory of the conference...... as a forum for learning, mutual inspiration and "human co-flourishing." We offer five design principles that specify how conferences may involve participants more and hence increase their learning. In the research and development effort reported here, our team collaborated with conference organizers...

  5. Community involvement

    Directory of Open Access Journals (Sweden)

    Editorial Office

    1979-09-01

    Full Text Available Community involvement is the main theme of Health Year. Governments have a responsibility for the health of their people, and in this country under the present 3-tier system of government, the responsibility for the rendering of health services is divided between central, provincial and local government. However, under our democratic system, all people have the right to, and it is indeed their duty, to participate individually and collectively in the planning and implementation of services to meet their health needs. Ultimately, through involvement of individuals, families and communities, greater self-reliance is achieved leading to greater responsibility being assumed by people for their own health.

  6. Disruption of the glutamate-glutamine cycle involving astrocytes in an animal model of depression for males and females

    Directory of Open Access Journals (Sweden)

    Virginie Rappeneau

    2016-12-01

    Full Text Available Background: Women are twice as likely as men to develop major depression (MD. The brain mechanisms underlying this sex disparity are not clear. Disruption of the glutamate-glutamine cycle has been implicated in psychiatric disturbances. This study identifies sex-based impairments in the glutamate-glutamine cycle involving astrocytes using an animal model of depression. Methods: Male and female adult Long-Evans rats were exposed to chronic social defeat stress (CSDS for 21 days, using a modified resident-intruder paradigm. Territorial aggression was used for males and maternal aggression was used for females to induce depressive-like deficits for intruders. The depressive-like phenotype was assessed with intake for saccharin solution, weight gain, estrous cycle, and corticosterone (CORT. Behaviors displayed by the intruders during daily encounters with residents were characterized. Rats with daily handling were used as controls for each sex. Ten days after the last encounter, both the intruders and controls were subjected to a no-net-flux in vivo microdialysis to assess glutamate accumulation and extracellular glutamine in the nucleus accumbens (NAc. The contralateral hemispheres were used for determining changes in astrocytic markers, including glial fibrillary acidic protein (GFAP and glutamate transporter-1 (GLT-1. Results: Both male and female intruders reduced saccharin intake over the course of CSDS, compared to their pre-stress period and to their respective controls. Male intruders exhibited submissive/defensive behaviors to territorial aggression by receiving sideways threats and bites. These males showed reductions in striatal GLT-1 and spontaneous glutamine in the NAc, compared to controls. Female intruders exhibited isolated behaviors to maternal aggression, including immobility, rearing, and self-grooming. Their non-reproductive days were extended. Also, they showed reductions in prefrontal and accumbal GFAP+ cells and prefrontal GLT

  7. Devising the prosthetic prescription and typical examples.

    Science.gov (United States)

    Passero, Thomas

    2014-02-01

    Limb deficiency has a significant impact on the involved person, with upper limb absence presenting a materially different set of issues than lower limb absence. The primary objectives in fitting a patient with a prosthesis are to enhance their independence in performing daily activities, and to improve their quality of life. For lower limb absence, the primary issues are safety, stability, and the ability to ambulate in a manner consistent with their overall health. The primary objectives in prescribing upper limb prosthetics are function, durability, appearance, comfort, and usability of the device. This article discusses the nuances associated with managing these patients.

  8. HENOCH - SCHONLEIN PURPURA : A TYPICAL PRESENTATION

    Directory of Open Access Journals (Sweden)

    Mohammed Abrar

    2015-07-01

    Full Text Available Henoch - Schonlein P urpura (HSP is the most common vasculitis of childhood and is characterized by leukocytoclastic vasculitis and immunoglobulin (Ig A deposition in the small vessels in the skin, joints, gastrointestinal tract, and kidney. It is a systemic disease where antigen - antibody (IgA complexes activate the alternate complement pathway, resulting in inflammation and small ve ssel vasculitis. Here we are reporting an interesting case of an adolescent female with atypical presentation (hypovolemic shock, erosive gastritis, skin involvement of the extremities requiring very high degree of suspicion for the diagnosis.

  9. Volatile S-nitrosothiols and the typical smell of cancer.

    Science.gov (United States)

    Schroeder, Wolfgang

    2015-03-09

    An unconventional approach to investigations into the identification of typical volatile emissions during illnesses gives rise to the proposal of a new class of cancer markers. Until now, cancer markers seem not to have been conclusively identified, though the obvious behavior of dogs points to their existence. The focus has been directed towards molecules containing sulfurous functionalities. Among such compounds, S-nitrosothiols (SNOs) are known to be involved in important physiological processes in living organisms and they are described as being typically elevated in cancer. Volatile SNOs (vSNOs) are proposed to be the source of the significant smell of cancer. Synthetic vSNOs are known to have lifetimes of between some minutes and several hours, which may be the main reason as to why they have been ignored until now, and also for the inability of analytics to detect them in vivo. Based on typical structures occurring in the volatile sulfur organics being emitted from human breath, four vSNOs have been synthesized and characterized by tandem mass spectrometry and gas chromatography/mass spectrometry. Simulating the relatively fatty consistency of cancer tissue by diluting the samples in n-decane, surprisingly reduces their tendency to decompose to lifetimes of weeks even at room temperature. A sniffer dog was trained with the synthetic vSNOs, and the results of the tests indicate that synthetic and cancer smells are very similar or even the same. The findings can be a clue for further target-oriented systematic optimization of existing sensitive measurement methods to prove vSNOs as cancer emissions and finally establish future methods for cancer diagnosis based on screening for this new class of volatile illness markers.

  10. An MCDA and GIS coupling conceptual model to be used in a circular decision process by stakeholders involved in large wind farm projects

    Energy Technology Data Exchange (ETDEWEB)

    Vazquez, M. [Quebec Univ., Rimouski, PQ (Canada). Laboratoire de Recherche en Energie Eolienne; Quebec Univ., Montreal, PQ (Canada). GEIGER; Waaub, J.P. [Quebec Univ., Montreal, PQ (Canada). GEIGER; Ilinca, A. [Quebec Univ., Rimouski, PQ (Canada). Laboratoire de Recherche en Energie Eolienne

    2010-07-01

    This poster presentation described an MCDA and geographic information system (GIS) coupling conceptual model designed for use in stakeholder decision-making processes for large wind farm projects. The model was comprised of 4 modules and 4 stakeholder categories that considered the environment and communities involved in the project. The integrated modelling approach was designed to ensure a transparent decision-making process. The modules included: (1) an MCDA module, (2) a local expertise and scientific knowledge module, (3) a stakeholder involvement module, and (4) a participatory GIS module. The model can be used to structure issues during consultation procedures, as well as to conduct preference analyses and to identify indicators. Examples of stakeholder weighting were included. tabs., figs.

  11. TYPICAL ABSENCES: RESULTS OF OWN INVESTIGATIONS

    Directory of Open Access Journals (Sweden)

    K. Yu. Mukhin

    2015-01-01

    Full Text Available Typical absences (TA are brief primary generalized epileptic seizures characterized by sudden onset and termination. According to their definition, absences consist of impairment of consciousness that is synchronously accompanied by electroencephalographic (EEG changes as generalized spike–slow wave discharges of 3 or more Hz. The authors conducted an investigation of 1261 patients with different forms of epilepsy with onset of seizures from the first days of life to the age of 18 years. The patients were followed up from 1990 to 2010. Absence seizures were detected in 231 patients, which accounts for 18.3 % of all the epileptic patients. TA were found in 102 patients, which constitutes 8.1 % of all cases of epilepsy with onset of seizures beyond the age of 18 years. The paper provides a detailed analysis of a group of patients with TA in terms of anamnestic, clinical, electroencephalographic, and neuroimaging features and the results of therapy with antiepileptic drugs (AEDs. The age of onset of TA-associated epilepsy was from 9 months to 17 years (mean 9.4 ± 4.06 years. The disease occurred most frequently in young school-age children (41.2 %. Isolated TA as the only type of seizures were observed in the clinical picture of 28 (27.5 % patients. TA were concurrent with other types of seizures in other cases. The investigators have identified 4 types of seizures which TA (generalized convulsions, myoclonic seizures, febrile seizures, and eyelid myoclonia may be concurrent with. Neuroimaging stated there were no brain changes in 85.3 % of TA-associated epilepsy cases. Moderate diffuse subatrophic changes were detected in other cases (14.7 %. Local cerebral structural abnormalities were absent. The use of antiepileptic therapy as both monotherapy and polytherapy using different combinations showed the high efficacy of AEDs. Complete remission was achieved in 84.3 % of TA-associated epilepsy cases. An AED-induced reduction in the frequency of

  12. Models predicting non-sentinel node involvement also predict for regional recurrence in breast cancer patients without axillary treatment

    NARCIS (Netherlands)

    Pepels, M.J.; Vestjens, J.H.; Boer, M. de; Bult, P.; Dijck, J.A.A.M. van; Menke-Pluijmers, M.; Diest, P.J. van; Borm, G.; Tjan-Heijnen, V.C.

    2013-01-01

    BACKGROUND: Non-SN prediction models are frequently used in clinical decision making to identify patients that may not need axillary treatment, but these models still need to be validated by follow-up data. Our purpose was the validation of non-sentinel node (SN) prediction models in predicting

  13. Porokeratosis ptychotropica: a rare manifestation with typical histological exam*

    Science.gov (United States)

    Veasey, John Verrinder; Dalapicola, Monique Coelho; Lellis, Rute Facchini; Campaner, Adriana Bittencourt; Manzione, Thiago da Silveira; Rodrigues, Maria Clarissa de Faria Soares

    2016-01-01

    Porokeratosis is a disorder of epidermal keratinization characterized clinically by a distinctive ridge-like border, and histologically by cornoid lamellae. The known clinical variants of porokeratosis are: classic porokeratosis of Mibelli, disseminated superficial (actinic) porokeratosis (DSAP), porokeratosis palmaris et plantaris disseminata, linear porokeratosis and punctate porokeratosis. In 1995, a seventh form was described as porokeratosis ptychotropica: a verrucous form resembling psoriasis involving the gluteal cleft presenting on the histological exam multiple cornoid lamellae. There are very few reports in the literature of this clinical variant. The present study describes the case of a healthy male presenting gluteal hyperkeratotic plaques for 22 years. He had been to several dermatologists, none of them had achieved a definitive diagnosis. We present a typical clinical presentation and its dermoscopy findings, in addition to histological examination that confirmed the diagnosis. PMID:27579746

  14. The Relationship between School Leaders' Perceptions of High Involvement Model Characteristics in Their Organizations and Their Attitudes towards the Use of the Change Toolkit to Facilitate Organizational Change

    Science.gov (United States)

    Kelly, Mary T.

    2009-01-01

    The purpose of this study was to investigate whether there was a relationship between school leaders' perceptions regarding High Involvement Model variables as components of their organizations, including power, knowledge, information, leadership, instructional guidance, rewards, and resources, and the leaders' ability to successfully use the IBM…

  15. Entropy and the Typicality of Universes

    CERN Document Server

    Barbour, Julian; Mercati, Flavio

    2015-01-01

    The universal validity of the second law of thermodynamics is widely attributed to a finely tuned initial condition of the universe. This creates a problem: why is the universe atypical? We suggest that the problem is an artefact created by inappropriate transfer of the traditional concept of entropy to the whole universe. Use of what we call the relational $N$-body problem as a model indicates the need to employ two distinct entropy-type concepts to describe the universe. One, which we call entaxy, is novel. It is scale-invariant and decreases as the observable universe evolves. The other is the algebraic sum of the dimensionful entropies of branch systems (isolated subsystems of the universe). This conventional additive entropy increases. In our model, the decrease of entaxy is fundamental and makes possible the emergence of branch systems and their increasing entropy. We have previously shown that all solutions of our model divide into two halves at a unique `Janus point' of maximum disorder. This constitu...

  16. The typical mass ratio and typical final spin in supermassive black hole mergers

    CERN Document Server

    Gergely, László Á

    2012-01-01

    We prove that merging supermassive black holes (SMBHs) typically have neither equal masses, nor is their mass ratio too extreme. The majority of such mergers fall into the mass ratio range of 1:30 to 1:3, implying a spin flip during the inspiral. We also present a simple expression for the final spin $\\chi_{f}$ of the emerging SMBH, as function of the mass ratio, initial spin magnitudes, and orientation of the spins with respect to the orbital plane and each other. This formula approximates well more cumbersome expressions obtained from the fit with numerical simulations. By integrating over all equally likely orientations for precessing mergers we determine a lower approximant to the final spin distribution as function of the mass ratio alone. By folding this with the derived mass ratio dependent merger rate we derive a lower bound to the typical final spin value after mergers. We repeat the procedure deriving an upper bound for the typical spin in the case when the spins are aligned to the orbital angular m...

  17. Green spermatozoa illuminate a 30-year-old model:sperm-egg adhesion involves intra-acrosomal proteins

    Institute of Scientific and Technical Information of China (English)

    Steve Tardif

    2011-01-01

    @@ Fertilisation in mammals involves many synchronized steps including spermegg adhesion.Prior to sperm-oolemma fusion,spermatozoa need to undergo the acrosome reaction (AR) or exocytosis.The universal belief,for many years,has been that the AR was initiated upon binding to the zona pellucida (ZP).As such acrosomal proteins were not thought to be involved in the primary contact with the ZP.These proteins were only suggested to be biologically relevant once the sperm were attached to the ZP and during subsequent events.However,recent data in the mouse have unequivocally demonstrated that spermatozoa can begin exocytosis before contact with ZP.1 It is a remarkable finding as not only will the interpretation of the interaction between sperm and cumulus cells need to be revised,but the processes of capacitation,vesiculation and exposure of acrosomal content need reexamination.

  18. A six-stage model of brand loyalty for sport consumers: Integrating theories of enduring involvement, identity and loyalty

    OpenAIRE

    Argus, Kevin James

    2017-01-01

    This thesis explores the formative antecedents and stages leading to consumers’ enduring involvement (EI) and loyalty with brands and products. This aim was pursued by conducting a study of sport consumers, of varying duration and intensity of EI and loyalty. A further aim was to determine whether the motives of consumers’ transitions between these stages of EI provide insights that explain their transitions between stages of brand loyalty and/or product loyalty. Of pa...

  19. The Effects of the Behavior Analysis Model of Follow Through to Increase Native American Involvement in the Classroom Educational Process.

    Science.gov (United States)

    McLaughlin, T. F.; And Others

    1980-01-01

    The effects of the Behavior Analysis Model of Follow Through as to the percent of Native Americans in instructional roles were examined. Large percentage increases were found in the use of Native Americans in the classroom as a function of the adoption of the Behavior Analysis Model of Follow Through. (Author)

  20. Mechanical Response of Typical Cement Concrete Pavements under Impact Loading

    Directory of Open Access Journals (Sweden)

    Ding Fei

    2017-01-01

    Full Text Available In order to study the mechanical response of cement concrete pavements under impact loading, four types of typical cement concrete pavement structures are investigated experimentally and numerically under an impact load. Full-scale three-dimensional pavement slots are tested under an impact load and are monitored for the mechanical characteristics including the deflection of the pavement surface layer, the strain distribution at the bottom of the slab, and the plastic damage and cracking under the dynamic impact load. Numerical analysis is performed by developing a three-dimensional finite element model and by utilizing a cement concrete damage model. The results show that the calculation results based on the cement concrete damage model are in reasonable agreement with the experimental results based on the three-dimensional test slot experiment. The peak values of stress and strain as monitored by the sensors are analyzed and compared with the numerical results, indicating that the errors of numerical results from the proposed model are mostly within 10%. The rationality of the finite element model is verified, and the model is expected to be a suitable reference for the analysis and design of cement concrete pavements.

  1. Infiuence of Bicycle Traffic on Capacity of Typical Signalized Intersection

    Institute of Scientific and Technical Information of China (English)

    CHEN Xiaoming; SHAO Chunfu; YUE Hao

    2007-01-01

    Bicycle traffic has a significant effect on the capacity of signalized intersections. This paper divides the influence of bicyclists on vehicular flow into four types with the time durations estimated based on probability, shock wave, and gap acceptance theory. Vehicular saturation flow rate is predicted for various conditions on the basis of the speed-flow curve for the capacity of typical intersections influenced by bicycle traffic.The model overcomes the limitations of the Highway Capacity Manual (HCM, 2000) method for left-turns due to data collection, and takes into account the effect of trapped bicycles on the through vehicular traffic.The numerical results show that the left-turn and through capacities predicted by the model are lower than those of the HCM method. The right-turn capacity is close to that of the HCM method at Iow bicycle volumes and higher than that of the HCM method at high bicycle volumes.

  2. Application of the"typical"in artistic creation

    Institute of Scientific and Technical Information of China (English)

    刘臣臣

    2014-01-01

    Art in the creation of the"typical"is the typical art. Its meaning is often explained as: refers to artists through individual and nature created, some essence and law can reflect the reality of life, but also has the unique feature, which show some times people's aesthetic ideal, and showed the artists own unique aesthetic feeling of artistic image. Mainly refers to the character image, known as the "typical character" "typical character" or"typical character", but also refers to the environment or the event, called "a typical environment" or "typical events". Art was typical of image usually is the highly generalization is representative of the people or things in real life and the summary, the formation of artistic works in the image by retouching the, in fact typical art image is more vivid than reality, universal higher and the aesthetic value of richer.

  3. Pancreatic Involvement in Melioidosis

    Directory of Open Access Journals (Sweden)

    Vui Heng Chong

    2010-07-01

    Full Text Available Context Melioidosis is endemic to tropical regions and, despite the common occurrence of intra-abdominal abscesses, pancreatic involvement in melioidosis has not previously been reported. Objective We report our experience with pancreatic melioidosis. Patients All 65 patients treated for melioidosis who had computed tomography (CT scans were identified from prospective databases and were retrospectively reviewed. Main outcome measures A detailed review of cases with pancreas involvement was carried out. Results There were four cases (three males and one female; median age 29.5 years, range: 25-48 years with pancreatic melioidosis, giving a prevalence of 6.2%. All had predisposing conditions (two had poorly controlled diabetes mellitus and two had thalassemia for melioidosis. Fever (100%, anorexia (100%, weight loss (100%, rigor (75% and abdominal pain (75% were the most common symptoms at presentation and the median duration of symptoms before presentation was six weeks (range: 2-8 weeks. All pancreatic abscesses were detected on CT scan. Multiple foci involvement was common (3 to 6 sites: blood (4 patients, liver (3 patients, psoas muscle (2 patients, spleen (2 patients, infected ascites (2 patients and lung (1 patient. Pancreatic involvement ranged from multi-focal micro-abscesses to focal large abscesses and involved all parts of the pancreas (body 100%, head 75% and tail 50%. Associated pancreatic findings included splenic vein thrombosis, peripancreatic inflammation and peripancreatic fat streaking. All the pancreatic abscesses were resolved with antibiotics without requiring pancreatic abscess drainage (including one patient who died from disseminated melioidosis. Conclusion Pancreatic involvement typically occurs as part of multi-organ involvement and commonly manifests as multifoci micro-abscesses. Associated pancreatic abnormalities were also common. All responded to treatment without requiring drainage

  4. Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer

    Science.gov (United States)

    Heger, Zbynek; Merlos Rodrigo, Miguel Angel; Michalek, Petr; Polanska, Hana; Masarik, Michal; Vit, Vitezslav; Plevova, Mariana; Pacik, Dalibor; Eckschlager, Tomas; Stiborova, Marie

    2016-01-01

    The effects of sarcosine on the processes driving prostate cancer (PCa) development remain still unclear. Herein, we show that a supplementation of metastatic PCa cells (androgen independent PC-3 and androgen dependent LNCaP) with sarcosine stimulates cells proliferation in vitro. Similar stimulatory effects were observed also in PCa murine xenografts, in which sarcosine treatment induced a tumor growth and significantly reduced weight of treated mice (p < 0.05). Determination of sarcosine metabolism-related amino acids and enzymes within tumor mass revealed significantly increased glycine, serine and sarcosine concentrations after treatment accompanied with the increased amount of sarcosine dehydrogenase. In both tumor types, dimethylglycine and glycine-N-methyltransferase were affected slightly, only. To identify the effects of sarcosine treatment on the expression of genes involved in any aspect of cancer development, we further investigated expression profiles of excised tumors using cDNA electrochemical microarray followed by validation using the semi-quantitative PCR. We found 25 differentially expressed genes in PC-3, 32 in LNCaP tumors and 18 overlapping genes. Bioinformatical processing revealed strong sarcosine-related induction of genes involved particularly in a cell cycle progression. Our exploratory study demonstrates that sarcosine stimulates PCa metastatic cells irrespectively of androgen dependence. Overall, the obtained data provides valuable information towards understanding the role of sarcosine in PCa progression and adds another piece of puzzle into a picture of sarcosine oncometabolic potential. PMID:27824899

  5. Parental involvement, child effort, and the development of immigrant boys' and girls' reading and mathematics skills: A latent difference score growth model.

    Science.gov (United States)

    Moon, Ui Jeong; Hofferth, Sandra L

    2016-04-01

    Gender differences in elementary school performance among immigrant children have not yet been well documented. This study examined how differences in parental involvement, child effort, and family characteristics and resources contribute to immigrant boys'-and girls' academic achievement from kindergarten through 5(th)-grade. The sample was drawn from the Early Childhood Longitudinal Study-Kindergarten cohort. Using a latent score growth model, this study found that parents' involvement at home benefited boys' reading and mathematics skills throughout all early elementary school years, but did not have the same benefit for girls. For both boys and girls, child effort in reading appears to be strongly linked to better reading and mathematics skills at kindergarten and to subsequent improvement between grades. The positive associations of parental involvement and child's effort with test scores were greater during earlier years than during later years for boys, whereas there was no difference in the association over time for girls.

  6. Modelling dopaminergic and other processes involved in learning from reward prediction error: Contributions from an individual differences perspective

    Directory of Open Access Journals (Sweden)

    Alan David Pickering

    2014-09-01

    Full Text Available Phasic firing changes of midbrain dopamine neurons have been widely characterised as reflecting a reward prediction error (RPE. Major personality traits (e.g. extraversion have been linked to inter-individual variations in dopaminergic neurotransmission. Consistent with these two claims, recent research (Smillie, Cooper, & Pickering, 2011; Cooper, Duke, Pickering, & Smillie, 2014 found that extraverts exhibited larger RPEs than introverts, as reflected in feedback related negativity (FRN effects in EEG recordings. Using an established, biologically-localised RPE computational model, we successfully simulated dopaminergic cell firing changes which are thought to modulate the FRN. We introduced simulated individual differences into the model: parameters were systematically varied, with stable values for each simulated individual. We explored whether a model parameter might be responsible for the observed covariance between extraversion and the FRN changes in real data, and argued that a parameter is a plausible source of such covariance if parameter variance, across simulated individuals, correlated almost perfectly with the size of the simulated dopaminergic FRN modulation, and created as much variance as possible in this simulated output. Several model parameters met these criteria, while others did not. In particular, variations in the strength of connections carrying excitatory reward drive inputs to midbrain dopaminergic cells were considered plausible candidates, along with variations in a parameter which scales the effects of dopamine cell firing bursts on synaptic modification in ventral striatum. We suggest possible neurotransmitter mechanisms underpinning these model parameters. Finally, the limitations and possible extensions of our approach are discussed.

  7. Modeling dopaminergic and other processes involved in learning from reward prediction error: contributions from an individual differences perspective.

    Science.gov (United States)

    Pickering, Alan D; Pesola, Francesca

    2014-01-01

    Phasic firing changes of midbrain dopamine neurons have been widely characterized as reflecting a reward prediction error (RPE). Major personality traits (e.g., extraversion) have been linked to inter-individual variations in dopaminergic neurotransmission. Consistent with these two claims, recent research (Smillie et al., 2011; Cooper et al., 2014) found that extraverts exhibited larger RPEs than introverts, as reflected in feedback related negativity (FRN) effects in EEG recordings. Using an established, biologically-localized RPE computational model, we successfully simulated dopaminergic cell firing changes which are thought to modulate the FRN. We introduced simulated individual differences into the model: parameters were systematically varied, with stable values for each simulated individual. We explored whether a model parameter might be responsible for the observed covariance between extraversion and the FRN changes in real data, and argued that a parameter is a plausible source of such covariance if parameter variance, across simulated individuals, correlated almost perfectly with the size of the simulated dopaminergic FRN modulation, and created as much variance as possible in this simulated output. Several model parameters met these criteria, while others did not. In particular, variations in the strength of connections carrying excitatory reward drive inputs to midbrain dopaminergic cells were considered plausible candidates, along with variations in a parameter which scales the effects of dopamine cell firing bursts on synaptic modification in ventral striatum. We suggest possible neurotransmitter mechanisms underpinning these model parameters. Finally, the limitations and possible extensions of our general approach are discussed.

  8. A Blended Learning Approach to Teaching Project Management: A Model for Active Participation and Involvement: Insights from Norway

    Directory of Open Access Journals (Sweden)

    Bassam A. Hussein

    2015-04-01

    Full Text Available The paper demonstrates and evaluates the effectiveness of a blended learning approach to create a meaningful learning environment. We use the term blended learning approach in this paper to refer to the use of multiple or hybrid instructional methods that emphasize the role of learners as contributors to the learning process rather than recipients of learning. Contribution to learning is attained by using in class gaming as pathways that ensure active involvement of learners. Using a blended learning approach is important in order to be able to address different learning styles of the target group. The approach was also important in order to be able to demonstrate different types of challenges, issues and competences needed in project management. Student evaluations of the course confirmed that the use of multiple learning methods and, in particular, in class gaming was beneficial and contributed to a meaningful learning experience.

  9. Intestinal epithelial restitution. Involvement of specific laminin isoforms and integrin laminin receptors in wound closure of a transformed model epithelium

    DEFF Research Database (Denmark)

    Lotz, M M; Nusrat, A; Madara, J L;

    1997-01-01

    Disruptions in the mucosal lining of the gastrointestinal tract reseal by epithelial cell migration, a process termed restitution. We examined the involvement of laminin isoforms and their integrin receptors in restitution using the intestinal epithelial cell line T84. T84 cells express primarily...... laminins 5, 6, and 7 as indicated by immunostaining using laminin subunit-specific monoclonal antibodies (MAbs). A MAb (BM2) specific for the laminin alpha 3 subunit, a component of laminins 5, 6, and 7, completely inhibited the closure of mechanical wounds in T84 monolayers. Confocal microscopy using MAbs...... BM2 (laminin alpha 3 subunit) and 6F12 (laminin beta 3 subunit) revealed that laminin-5 is deposited in a basal matrix that extends into the wound. The MAbs 4E10 (laminin beta 1 subunit) and C4 (laminin beta 2 subunit) stained the lateral membranes between T84 cells. This staining was enhanced...

  10. Exploring the experiences of client involvement in medication decisions using a shared decision making model: results of a qualitative study.

    Science.gov (United States)

    Goscha, Richard; Rapp, Charles

    2015-04-01

    This qualitative study explored a newly introduced model of shared decision making (CommonGround) and how psychiatric medications were experienced by clients, prescribers, case managers and peer support staff. Of the twelve client subjects, six were highly engaged in shared decision-making and six were not. Five notable differences were found between the two groups including the presence of a goal, use of personal medicine, and the behavior of case managers and prescribers. Implications for a shared decision making model in psychiatry are discussed.

  11. Typical exposure of children to EMF: exposimetry and dosimetry.

    Science.gov (United States)

    Valič, Blaž; Kos, Bor; Gajšek, Peter

    2015-01-01

    A survey study with portable exposimeters, worn by 21 children under the age of 17, and detailed measurements in an apartment above a transformer substation were carried out to determine the typical individual exposure of children to extremely low- and radio-frequency (RF) electromagnetic field. In total, portable exposimeters were worn for >2400 h. Based on the typical individual exposure the in situ electric field and specific absorption rate (SAR) values were calculated for an 11-y-old female human model. The average exposure was determined to be low compared with ICNIRP reference levels: 0.29 μT for an extremely low-frequency (ELF) magnetic field and 0.09 V m(-1) for GSM base stations, 0.11 V m(-1) for DECT and 0.10 V m(-1) for WiFi; other contributions could be neglected. However, some of the volunteers were more exposed: the highest realistic exposure, to which children could be exposed for a prolonged period of time, was 1.35 μT for ELF magnetic field and 0.38 V m(-1) for DECT, 0.13 V m(-1) for WiFi and 0.26 V m(-1) for GSM base stations. Numerical calculations of the in situ electric field and SAR values for the typical and the worst-case situation show that, compared with ICNIRP basic restrictions, the average exposure is low. In the typical exposure scenario, the extremely low frequency exposure is <0.03 % and the RF exposure <0.001 % of the corresponding basic restriction. In the worst-case situation, the extremely low frequency exposure is <0.11 % and the RF exposure <0.007 % of the corresponding basic restrictions. Analysis of the exposures and the individual's perception of being exposed/unexposed to an ELF magnetic field showed that it is impossible to estimate the individual exposure to an ELF magnetic field based only on the information provided by the individuals, as they do not have enough knowledge and information to properly identify the sources in their vicinity.

  12. A Heterogeneous Bayesian Regression Model for Cross-Sectional Data Involving a Single Observation per Response Unit

    Science.gov (United States)

    Fong, Duncan K. H.; Ebbes, Peter; DeSarbo, Wayne S.

    2012-01-01

    Multiple regression is frequently used across the various social sciences to analyze cross-sectional data. However, it can often times be challenging to justify the assumption of common regression coefficients across all respondents. This manuscript presents a heterogeneous Bayesian regression model that enables the estimation of…

  13. Youth Activity Involvement, Neighborhood Adult Support, Individual Decision Making Skills, and Early Adolescent Delinquent Behaviors: Testing a Conceptual Model

    Science.gov (United States)

    Crean, Hugh F.

    2012-01-01

    This study examines a cross-sectional structural equation model of participation in youth activities, neighborhood adult support, individual decision making skills, and delinquent behavior in urban middle school youths (n = 2611). Results indicate extracurricular activity participation had both direct and indirect associations with delinquent…

  14. Involvement of receptor tyrosine kinase Tyro3 in amyloidogenic APP processing and β-amyloid deposition in Alzheimer's disease models.

    Directory of Open Access Journals (Sweden)

    Yan Zheng

    Full Text Available Alzheimer's disease (AD is the most common progressive neurodegenerative disease known to humankind. It is characterized by brain atrophy, extracellular amyloid plaques, and intracellular neurofibril tangles. β-Amyloid cascade is considered the major causative player in AD. Up until now, the mechanisms underlying the process of Aβ generation and accumulation in the brain have not been well understood. Tyro3 receptor belongs to the TAM receptor subfamily of receptor protein tyrosine kinases (RPTKs. It is specifically expressed in the neurons of the neocortex and hippocampus. In this study, we established a cell model stably expressing APPswe mutants and producing Aβ. We found that overexpression of Tyro3 receptor in the cell model significantly decreased Aβ generation and also down-regulated the expression of β-site amyloid precursor protein cleaving enzyme (BACE1. However, the effects of Tyro3 were inhibited by its natural ligand, Gas6, in a concentration-dependent manner. In order to confirm the role of Tyro3 in the progression of AD development, we generated an AD transgenic mouse model accompanied by Tyro3 knockdown. We observed a significant increase in the number of amyloid plaques in the hippocampus in the mouse model. More plaque-associated clusters of astroglia were also detected. The present study may help researchers determine the role of Tyro3 receptor in the neuropathology of AD.

  15. Towards a Model of Teacher Well-Being: Personal and Job Resources Involved in Teacher Burnout and Engagement

    Science.gov (United States)

    Bermejo-Toro, Laura; Prieto-Ursúa, María; Hernández, Vicente

    2016-01-01

    Although much research has focused on the role of job demands and job resources in teacher well-being, few studies have targeted the function of personal variables. The aim of this study is to develop a comprehensive model of teacher well-being, using burnout and engagement in order to reflect, not only job demands and professional resources, but…

  16. Homology modeling of mosquito cytochrome P450 enzymes involved in pyrethroid metabolism: insights into differences in substrate selectivity

    Directory of Open Access Journals (Sweden)

    Rongnoparut Pornpimol

    2011-09-01

    Full Text Available Abstract Background Cytochrome P450 enzymes (P450s have been implicated in insecticide resistance. Anopheles minumus mosquito P450 isoforms CYP6AA3 and CYP6P7 are capable of metabolizing pyrethroid insecticides, however CYP6P8 lacks activity against this class of compounds. Findings Homology models of the three An. minimus P450 enzymes were constructed using the multiple template alignment method. The predicted enzyme model structures were compared and used for molecular docking with insecticides and compared with results of in vitro enzymatic assays. The three model structures comprise common P450 folds but differences in geometry of their active-site cavities and substrate access channels are prominent. The CYP6AA3 model has a large active site allowing it to accommodate multiple conformations of pyrethroids. The predicted CYP6P7 active site is more constrained and less accessible to binding of pyrethroids. Moreover the predicted hydrophobic interface in the active-site cavities of CYP6AA3 and CYP6P7 may contribute to their substrate selectivity. The absence of CYP6P8 activity toward pyrethroids appears to be due to its small substrate access channel and the presence of R114 and R216 that may prevent access of pyrethroids to the enzyme heme center. Conclusions Differences in active site topologies among CYPAA3, CYP6P7, and CYP6P8 enzymes may impact substrate binding and selectivity. Information obtained using homology models has the potential to enhance the understanding of pyrethroid metabolism and detoxification mediated by P450 enzymes.

  17. Assessment of University External Internships. Towards a Mixed Model for Measuring the Acquisition of Skills and the Satisfaction of Parties Involved

    OpenAIRE

    Ruiz Callado, Raúl

    2011-01-01

    The continuous improvement of management and assessment processes for curricular external internships has led a group of university teachers specialised in this area to develop a mixed model of measurement that combines the verification of skill acquisition by those students choosing external internships with the satisfaction of the parties involved in that process. They included academics, educational tutors of companies and organisations and administration and services personnel in the latt...

  18. Exact solutions to traffic density estimation problems involving the Lighthill-Whitham-Richards traffic flow model using mixed integer programming

    KAUST Repository

    Canepa, Edward S.

    2012-09-01

    This article presents a new mixed integer programming formulation of the traffic density estimation problem in highways modeled by the Lighthill Whitham Richards equation. We first present an equivalent formulation of the problem using an Hamilton-Jacobi equation. Then, using a semi-analytic formula, we show that the model constraints resulting from the Hamilton-Jacobi equation result in linear constraints, albeit with unknown integers. We then pose the problem of estimating the density at the initial time given incomplete and inaccurate traffic data as a Mixed Integer Program. We then present a numerical implementation of the method using experimental flow and probe data obtained during Mobile Century experiment. © 2012 IEEE.

  19. A hidden Markov model to identify and adjust for selection bias: an example involving mixed migration strategies

    OpenAIRE

    Fieberg, John R.; Paul B Conn

    2014-01-01

    An important assumption in observational studies is that sampled individuals are representative of some larger study population. Yet, this assumption is often unrealistic. Notable examples include online public-opinion polls, publication biases associated with statistically significant results, and in ecology, telemetry studies with significant habitat-induced probabilities of missed locations. This problem can be overcome by modeling selection probabilities simultaneously with other predicto...

  20. Errors Involved in the Taylor‘s Model for the Crustal Composition and Evolution—An Analysis of Their Causers

    Institute of Scientific and Technical Information of China (English)

    陈衍景; 秦善; 等

    1997-01-01

    It is suggested in this paper that the famous Taylor's model for the composition and evolution of the continental crust consists of three closely related key links.These links include an assumption that the surfical environment has no effect on the sedimentary REE patterns and the REE patterns in sdhales can reflect the composition of their provenance,a discovery about the discrepancy of sedimentary REE patterns between Archean and Proteroxoic,and a deduction that there was a global scale K-granitoid event at the end of the Archean.Based on a detailed discussion,this paper substantially negates the rationality of the Taylor's model and argues that its three critical links be three great errors indeed.Moreover,some other deficiencies or problems it confronts are described in this paper.The authors suggest that what led to the errors invoved in the Taylor's model is its wrongly neglecting the effect of the sedimentary envronment on the chemical composition of sediments.and that the environment should be an important factor affecting the distribution patterns of trace elements in the sediments.

  1. [Mechanisms involved in the regulation of immune response in animal model of rheumatoid arthritis in mice (CIA)].

    Science.gov (United States)

    Marcińska, Katarzyna; Szczepanik, Marian

    2010-08-04

    Rheumatoid arthritis (RA) represents an example of the autoimmune disease. With a prevalence of 1% worldwide, the pathogenesis of RA is not clear yet. At present it is thought that the pathogenesis of RA results from an inflammatory response mediated by CD4+ Th1 cells that recognize unidentified antigens present in bone joints. Recently, there is a growing evidence for a role for Th17 lymphocytes in autoimmunity, including RA, suggesting that this population of helper cells may be more important in the pathogenesis of RA than Th1 cells. Thus far, treatment modalities for RA are limited, with the prevailing one acting nonspecifically on the immune system. However, such an approach results in a general immunosuppression and is accompanied by severe side-effects. There is a large demand for developing RA therapy that particularly targets pathogenic antigen-specific T cells. Research on pathogenesis of the autoimmune diseases, and development of new drugs is now possible thanks to experimental animal models that mimic human diseases. Collagen-induced arthritis (CIA) in genetically susceptible strains of mice, rats, rabbits or rhesus monkeys has been used as an experimental model of RA, as it shares many histological and immunological features. The knowledge gained using this model allows to better understand the pathogenesis of RA and, consequently, to manipulate particular components of the immune system to develop efficient therapies.

  2. Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts

    Science.gov (United States)

    Guaitoli, Giambattista; Raimondi, Francesco; Gilsbach, Bernd K.; Gómez-Llorente, Yacob; Deyaert, Egon; Renzi, Fabiana; Li, Xianting; Schaffner, Adam; Jagtap, Pravin Kumar Ankush; Boldt, Karsten; von Zweydorf, Felix; Gotthardt, Katja; Lorimer, Donald D.; Yue, Zhenyu; Burgin, Alex; Janjic, Nebojsa; Sattler, Michael; Versées, Wim; Ueffing, Marius; Ubarretxena-Belandia, Iban; Kortholt, Arjan; Gloeckner, Christian Johannes

    2016-01-01

    Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein containing two catalytic domains: a Ras of complex proteins (Roc) G-domain and a kinase domain. Mutations associated with familial and sporadic Parkinson’s disease (PD) have been identified in both catalytic domains, as well as in several of its multiple putative regulatory domains. Several of these mutations have been linked to increased kinase activity. Despite the role of LRRK2 in the pathogenesis of PD, little is known about its overall architecture and how PD-linked mutations alter its function and enzymatic activities. Here, we have modeled the 3D structure of dimeric, full-length LRRK2 by combining domain-based homology models with multiple experimental constraints provided by chemical cross-linking combined with mass spectrometry, negative-stain EM, and small-angle X-ray scattering. Our model reveals dimeric LRRK2 has a compact overall architecture with a tight, multidomain organization. Close contacts between the N-terminal ankyrin and C-terminal WD40 domains, and their proximity—together with the LRR domain—to the kinase domain suggest an intramolecular mechanism for LRRK2 kinase activity regulation. Overall, our studies provide, to our knowledge, the first structural framework for understanding the role of the different domains of full-length LRRK2 in the pathogenesis of PD. PMID:27357661

  3. Microbial communities involved in enhanced biological phosphorus removal from wastewater--a model system in environmental biotechnology.

    Science.gov (United States)

    Nielsen, Per Halkjær; Saunders, Aaron Marc; Hansen, Aviaja Anna; Larsen, Poul; Nielsen, Jeppe Lund

    2012-06-01

    Enhanced biological phosphorus removal (EBPR) is one of the most advanced and complicated wastewater treatment processes applied today, and it is becoming increasingly popular worldwide as a sustainable way to remove and potentially reuse P. It is carried out by complex microbial communities consisting primarily of uncultured microorganisms. The EBPR process is a well-studied system with clearly defined boundaries which makes it very suitable as a model ecosystem in microbial ecology. Of particular importance are the transformations of C, N, and P, the solid-liquid separation properties and the functional and structural stability. A range of modern molecular methods has been used to study these communities in great detail including single cell microbiology, various -omics methods, flux analyses, and modeling making this one of the best studied microbial ecosystems so far. Recently, an EBPR core microbiome has been described and we present in this article some highlights and show how this complex microbial community can be used as model ecosystem in environmental biotechnology.

  4. A cellular model of memory reconsolidation involves reactivation-induced destabilization and restabilization at the sensorimotor synapse in Aplysia.

    Science.gov (United States)

    Lee, Sue-Hyun; Kwak, Chuljung; Shim, Jaehoon; Kim, Jung-Eun; Choi, Sun-Lim; Kim, Hyoung F; Jang, Deok-Jin; Lee, Jin-A; Lee, Kyungmin; Lee, Chi-Hoon; Lee, Young-Don; Miniaci, Maria Concetta; Bailey, Craig H; Kandel, Eric R; Kaang, Bong-Kiun

    2012-08-28

    The memory reconsolidation hypothesis suggests that a memory trace becomes labile after retrieval and needs to be reconsolidated before it can be stabilized. However, it is unclear from earlier studies whether the same synapses involved in encoding the memory trace are those that are destabilized and restabilized after the synaptic reactivation that accompanies memory retrieval, or whether new and different synapses are recruited. To address this issue, we studied a simple nonassociative form of memory, long-term sensitization of the gill- and siphon-withdrawal reflex in Aplysia, and its cellular analog, long-term facilitation at the sensory-to-motor neuron synapse. We found that after memory retrieval, behavioral long-term sensitization in Aplysia becomes labile via ubiquitin/proteasome-dependent protein degradation and is reconsolidated by means of de novo protein synthesis. In parallel, we found that on the cellular level, long-term facilitation at the sensory-to-motor neuron synapse that mediates long-term sensitization is also destabilized by protein degradation and is restabilized by protein synthesis after synaptic reactivation, a procedure that parallels memory retrieval or retraining evident on the behavioral level. These results provide direct evidence that the same synapses that store the long-term memory trace encoded by changes in the strength of synaptic connections critical for sensitization are disrupted and reconstructed after signal retrieval.

  5. Computational modeling of stuttering caused by impairments in a basal ganglia thalamo-cortical circuit involved in syllable selection and initiation

    Science.gov (United States)

    Civier, Oren; Bullock, Daniel; Max, Ludo; Guenther, Frank H.

    2013-01-01

    A typical white-matter integrity and elevated dopamine levels have been reported for individuals who stutter. We investigated how such abnormalities may lead to speech dysfluencies due to their effects on a syllable-sequencing circuit that consists of basal ganglia (BG), thalamus, and left ventral premotor cortex (vPMC). “Neurally impaired” versions of the neurocomputational speech production model GODIVA were utilized to test two hypotheses: (1) that white-matter abnormalities disturb the circuit via corticostriatal projections carrying copies of executed motor commands, and (2) that dopaminergic abnormalities disturb the circuit via the striatum. Simulation results support both hypotheses: in both scenarios, the neural abnormalities delay readout of the next syllable’s motor program, leading to dysfluency. The results also account for brain imaging findings during dysfluent speech. It is concluded that each of the two abnormality types can cause stuttering moments, probably by affecting the same BG-thalamus-vPMC circuit. PMID:23872286

  6. Monoarticular Hip Involvement in Pseudogout

    Directory of Open Access Journals (Sweden)

    Figen Kocyigit

    2015-01-01

    Full Text Available Pseudogout is the acutest form of arthritis in the elderly. Although clinical manifestations vary widely, polyarticular involvement is typical mimicking osteoarthritis or rheumatoid arthritis. Monoarticular involvement is relatively rare and is generally provoked by another medical condition. There are reported cases of hip involvement by pseudogout in monoarticular form. However, all of the cases were presented as septic arthritis. In this report, we present a case of monoarticular hip involvement mimicking soft tissue abscess. We confirmed the pseudogout diagnosis after ultrasonographic evaluation of the involved hip joint and pathological and biochemical analysis of synovial fluid analysis. Diagnosis is important to avoid unnecessary medical and surgical treatment in cases of the bizarre involvement of hip in pseudogout.

  7. Behavioral Signal Processing: Deriving Human Behavioral Informatics From Speech and Language: Computational techniques are presented to analyze and model expressed and perceived human behavior-variedly characterized as typical, atypical, distressed, and disordered-from speech and language cues and their applications in health, commerce, education, and beyond.

    Science.gov (United States)

    Narayanan, Shrikanth; Georgiou, Panayiotis G

    2013-02-01

    The expression and experience of human behavior are complex and multimodal and characterized by individual and contextual heterogeneity and variability. Speech and spoken language communication cues offer an important means for measuring and modeling human behavior. Observational research and practice across a variety of domains from commerce to healthcare rely on speech- and language-based informatics for crucial assessment and diagnostic information and for planning and tracking response to an intervention. In this paper, we describe some of the opportunities as well as emerging methodologies and applications of human behavioral signal processing (BSP) technology and algorithms for quantitatively understanding and modeling typical, atypical, and distressed human behavior with a specific focus on speech- and language-based communicative, affective, and social behavior. We describe the three important BSP components of acquiring behavioral data in an ecologically valid manner across laboratory to real-world settings, extracting and analyzing behavioral cues from measured data, and developing models offering predictive and decision-making support. We highlight both the foundational speech and language processing building blocks as well as the novel processing and modeling opportunities. Using examples drawn from specific real-world applications ranging from literacy assessment and autism diagnostics to psychotherapy for addiction and marital well being, we illustrate behavioral informatics applications of these signal processing techniques that contribute to quantifying higher level, often subjectively described, human behavior in a domain-sensitive fashion.

  8. Analysis of partial discharge Ultrasonic wave characteristic on typical Defects in GIS

    Directory of Open Access Journals (Sweden)

    Yang Jing Gang

    2016-01-01

    Full Text Available For analyzing partial discharge ultrasonic wave characteristic on typical defects in SF6 gas insulation switchgear (GIS, a 110 kV GIS was taken as an object to design and simulate the typical partial discharge models in GIS. There are point electrode model on bus and cavity of GIS, floating electrode model, air interstice model in insulator, metal particle and iron core electromagnetic shock models. PD signals on different defects were thus detected with the ultrasonic method. The experimental results indicated that the ultrasonic signals of different defects showed different characteristics in waveform, amplitude and phase resolved partial discharge chart, which is helpful in PD pattern recognition for GIS.

  9. Lung endothelial barrier protection by iloprost in the two-hit models of VILI involves inhibition of Rho signaling

    Science.gov (United States)

    Birukova, Anna A.; Fu, Panfeng; Xing, Junjie; Cokic, Ivan; Birukov, Konstantin G.

    2010-01-01

    Mechanical ventilation at high tidal volume may cause pulmonary capillary leakage and acute lung inflammation culminating in ventilator-induced lung injury. Iloprost is a stable synthetic analogue of prostaglandin I2 used for treatment of pulmonary hypertension, which also showed endothelium-dependent anti-edemagenic effects in the models of lung injury. To test the hypothesis that iloprost may attenuate lung inflammation and lung endothelial barrier disruption caused by pathologic lung distension and coagulation system component thrombin, we used cell and animal two-hit models of ventilator-induced lung injury. Mice received triple injection of iloprost (2 μg/kg, intravenous instillation) at 0, 40 and 80 min after onset of high tidal volume (HTV) mechanical ventilation (30 ml/kg, 4 hrs) combined with administration of thrombin receptor activating peptide 6 (TRAP6, 3 × 10−7 mol/mouse, intratracheal instillation). After 4 hrs of ventilation, bronchoalveolar lavage (BAL), histological analysis, and measurements of Evans blue accumulation in the lung tissue lung were performed. Effects of iloprost on endothelial barrier dysfunction were further assessed in pulmonary endothelial cells (EC) exposed to thrombin and pathologic (18%) cyclic stretch. Combination of HTV and TRAP6 enhanced accumulation of neutrophils in BAL fluid and lung parenchyma, increased BAL protein content and endothelial permeability judged by Evans blue extravasation in the lung tissue. These effects were markedly attenuated by iloprost. Application of 18% cyclic stretch to pulmonary EC enhanced thrombin-induced EC paracellular gap formation and Rho-GTPase-mediated phosphorylation of regulatory myosin light chains and myosin phosphatase. Iloprost markedly inhibited Rho-kinase mediated site-specific phosphorylation of myosin phosphatase, and prevented cyclic stretch- and thrombin-induced endothelial monolayer disruption. This study characterizes for the first time the protective effects of

  10. Antinociceptive Effect of Ghrelin in a Rat Model of Irritable Bowel Syndrome Involves TRPV1/Opioid Systems

    Directory of Open Access Journals (Sweden)

    Yuqing Mao

    2017-09-01

    Full Text Available Background/Aims: Irritable bowel syndrome (IBS, defined as recurrent abdominal pain and changes in bowel habits, seriously affects quality of life and ability to work. Ghrelin is a brain-gut hormone, which has been reported to show antinociceptive effects in peripheral pain. We investigated the effect of ghrelin on visceral hypersensitivity and pain in a rat model of IBS. Methods: Maternal deprivation (MD was used to provide a stress-induced model of IBS in Wistar rats. Colorectal distension (CRD was used to detect visceral sensitivity, which was evaluated by abdominal withdrawal reflex (AWR scores. Rats that were confirmed to have visceral hypersensitivity after MD were injected with ghrelin (10 µg/kg subcutaneously twice a week from weeks 7 to 8. [D-Lys3]-GHRP-6 (100 nmol/L and naloxone (100 nmol/L were administered subcutaneously to block growth hormone secretagogue receptor 1α (GHS-R1α and opioid receptors, respectively. Expression of transient receptor potential vanilloid type 1 (TRPV1 and µ and κ opioid receptors (MOR and KOR in colon, dorsal root ganglion (DRG and cerebral cortex tissues were detected by western blotting, quantitative real-time polymerase chain reaction (qRT-PCR, immunohistochemical analyses and immunofluorescence. Results: Ghrelin treatment increased expression of opioid receptors and inhibited expression of TRPV1 in colon, dorsal root ganglion (DRG and cerebral cortex. The antinociceptive effect of ghrelin in the rat model of IBS was partly blocked by both the ghrelin antagonist [D-Lys3]-GHRP-6 and the opioid receptor antagonist naloxone. Conclusion: The results indicate that ghrelin exerted an antinociceptive effect, which was mediated via TRPV1/opioid systems, in IBS-induced visceral hypersensitivity. Ghrelin might potentially be used as a new treatment for IBS.

  11. Murine neural stem cells model Hunter disease in vitro: glial cell-mediated neurodegeneration as a possible mechanism involved.

    Science.gov (United States)

    Fusar Poli, E; Zalfa, C; D'Avanzo, F; Tomanin, R; Carlessi, L; Bossi, M; Nodari, L Rota; Binda, E; Marmiroli, P; Scarpa, M; Delia, D; Vescovi, A L; De Filippis, L

    2013-11-07

    Mucopolysaccharidosis type II (MPSII or Hunter Syndrome) is a lysosomal storage disorder caused by the deficit of iduronate 2-sulfatase (IDS) activity and characterized by progressive systemic and neurological impairment. As the early mechanisms leading to neuronal degeneration remain elusive, we chose to examine the properties of neural stem cells (NSCs) isolated from an animal model of the disease in order to evaluate whether their neurogenic potential could be used to recapitulate the early phases of neurogenesis in the brain of Hunter disease patients. Experiments here reported show that NSCs derived from the subventricular zone (SVZ) of early symptomatic IDS-knockout (IDS-ko) mouse retained self-renewal capacity in vitro, but differentiated earlier than wild-type (wt) cells, displaying an evident lysosomal aggregation in oligodendroglial and astroglial cells. Consistently, the SVZ of IDS-ko mice appeared similar to the wt SVZ, whereas the cortex and striatum presented a disorganized neuronal pattern together with a significant increase of glial apoptotic cells, suggesting that glial degeneration likely precedes neuronal demise. Interestingly, a very similar pattern was observed in the brain cortex of a Hunter patient. These observations both in vitro, in our model, and in vivo suggest that IDS deficit seems to affect the late phases of neurogenesis and/or the survival of mature cells rather than NSC self-renewal. In particular, platelet-derived growth factor receptor-α-positive (PDGFR-α+) glial progenitors appeared reduced in both the IDS-ko NSCs and in the IDS-ko mouse and human Hunter brains, compared with the respective healthy controls. Treatment of mutant NSCs with IDS or PDGF throughout differentiation was able to increase the number of PDGFR-α+ cells and to reduce that of apoptotic cells to levels comparable to wt. This evidence supports IDS-ko NSCs as a reliable in vitro model of the disease, and suggests the rescue of PDGFR-α+ glial cells as a

  12. Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel loci

    Science.gov (United States)

    Evans, Jacquelyn M.; Hill, Cody M.; Anderson, Kendall J.

    2017-01-01

    Juvenile dermatomyositis (JDM) is a chronic inflammatory myopathy and vasculopathy driven by genetic and environmental influences. Here, we investigated the genetic underpinnings of an analogous, spontaneous disease of dogs also termed dermatomyositis (DMS). As in JDM, we observed a significant association with a haplotype of the major histocompatibility complex (MHC) (DLA-DRB1*002:01/-DQA1*009:01/-DQB1*001:01), particularly in homozygosity (P-val = 0.0001). However, the high incidence of the haplotype among healthy dogs indicated that additional genetic risk factors are likely involved in disease progression. We conducted genome-wide association studies in two modern breeds having common ancestry and detected strong associations with novel loci on canine chromosomes 10 (P-val = 2.3X10-12) and 31 (P-val = 3.95X10-8). Through whole genome resequencing, we identified primary candidate polymorphisms in conserved regions of PAN2 (encoding p.Arg492Cys) and MAP3K7CL (c.383_392ACTCCACAAA>GACT) on chromosomes 10 and 31, respectively. Analyses of these polymorphisms and the MHC haplotypes revealed that nine of 27 genotypic combinations confer high or moderate probability of disease and explain 93% of cases studied. The pattern of disease risk across PAN2 and MAP3K7CL genotypes provided clear evidence for a significant epistatic foundation for this disease, a risk further impacted by MHC haplotypes. We also observed a genotype-phenotype correlation wherein an earlier age of onset is correlated with an increased number of risk alleles at PAN2 and MAP3K7CL. High frequencies of multiple genetic risk factors are unique to affected breeds and likely arose coincident with artificial selection for desirable phenotypes. Described herein is the first three-locus association with a complex canine disease and two novel loci that provide targets for exploration in JDM and related immunological dysfunction. PMID:28158183

  13. Hairless expression attenuates apoptosis in a mouse model and the COS cell line; involvement of p53.

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    Cliona O'Driscoll

    Full Text Available BACKGROUND: Neurons are more likely to die through apoptosis in the immature brain after injury whereas adult neurons in the mature brain die by necrosis. Several studies have suggested that this maturational change in the mechanism of cell death is regulated, in part, by thyroid hormone. We examined the involvement of the hairless (Hr gene which has been suspected of having a role in cell cycle regulation and apoptosis in the hair follicle and is strongly regulated by the thyroid hormone in the brain. METHODOLOGY: Forced expression of Hr by transfection decreased the number of apoptotic nuclei, levels of caspase-3 activity, and cytosolic cytochrome C in COS cells exposed to staurosporine and tunicamycin. Similarly, caspase-3 activity was lower and the decrease in mitochondrial membrane potential was smaller in cultures of adult cerebellar granule neurons from wild type mice compared to Hr knockout mice induced to undergo apoptosis. In vivo, apoptosis as detected by positive TUNEL labeling and caspase 3 activity was lower in wild-type mice compared to Hr knockouts after exposure to trimethyltin. Hr expression lowered levels of p53, p53 mediated reporter gene activity, and lower levels of the pro-apoptotic Bcl2 family member Bax in COS cells. Finally, Hr expression did not attenuate apoptosis in mouse embryonic fibroblasts from p53 knockout mice but was effective in mouse embryonic fibroblasts from wild type mice. CONCLUSIONS/SIGNIFICANCE: Overall, our studies demonstrate that Hr evokes an anti-apoptotic response by repressing expression of p53 and pro-apoptotic events regulated by p53.

  14. A novel orally available inhibitor of focal adhesion signaling increases survival in a xenograft model of diffuse large B-cell lymphoma with central nervous system involvement.

    Science.gov (United States)

    Bosch, Rosa; Moreno, María José; Dieguez-Gonzalez, Rebeca; Céspedes, María Virtudes; Gallardo, Alberto; Trias, Manuel; Grañena, Albert; Sierra, Jorge; Casanova, Isolda; Mangues, Ramon

    2013-08-01

    Central nervous system dissemination is a relatively uncommon but almost always fatal complication in diffuse large B-cell lymphoma patients. Optimal therapy for central nervous involvement in this malignancy has not been established. In this paper, we aimed to evaluate the therapeutic effect of E7123, a celecoxib derivative that inhibits focal adhesion signaling, in a novel xenograft model of diffuse large B-cell lymphoma with central nervous system involvement. Cells obtained after disaggregation of HT subcutaneous tumors (HT-SC cells) were intravenously injected in NOD/SCID mice. These mice received oral vehicle or 75 mg/kg of E7123 daily until they were euthanized for weight loss or signs of sickness. The antitumor effect of E7123 was validated in an independent experiment using a bioluminescent mouse model. Intravenously injected HT-SC cells showed higher take rate and higher central nervous system tropism (associated with increased expression of β1-integrin and p130Cas proteins) than HT cells. The oral administration of E7123 significantly increased survival time in 2 independent experiments using mice injected with unmodified or bioluminescent HT-SC cells. We have developed a new xenograft model of diffuse large B-cell lymphoma with central nervous system involvement that can be used in the pre-clinical evaluation of new drugs for this malignancy. E7123 is a new, well-tolerated and orally available therapeutic agent that merits further investigation since it may improve current management of diffuse large B-cell lymphoma patients with central nervous system involvement.

  15. Modeling of Glycerol-3-Phosphate Transporter Suggests a Potential ‘Tilt’ Mechanism involved in its Function

    Science.gov (United States)

    Tsigelny, Igor F.; Greenberg, Jerry; Kouznetsova, Valentina; Nigam, Sanjay K.

    2009-01-01

    Many major facilitator superfamily (MFS) transporters have similar 12-transmembrane α-helical topologies with two six-helix halves connected by a long loop. In humans, these transporters participate in key physiological processes and are also, as in the case of members of the organic anion transporter (OAT) family, of pharmaceutical interest. Recently, crystal structures of two bacterial representatives of the MFS family — the glycerol-3-phosphate transporter (GlpT) and lac-permease (LacY) — have been solved and, because of assumptions regarding the high structural conservation of this family, there is hope that the results can be applied to mammalian transporters as well. Based on crystallography, it has been suggested that a major conformational “switching” mechanism accounts for ligand transport by MFS proteins. This conformational switch would then allow periodic changes in the overall transporter configuration, resulting in its cyclic opening to the periplasm or cytoplasm. Following this lead, we have modeled a possible “switch” mechanism in GlpT, using the concept of rotation of protein domains as in the DynDom program17 and membranephilic constraints predicted by the MAPAS program.23 We found that the minima of energies of intersubunit interactions support two alternate positions consistent with their transport properties. Thus, for GlpT, a “tilt” of 9°–10° rotation had the most favorable energetics of electrostatic interaction between the two halves of the transporter; moreover, this confirmation was sufficient to suggest transport of the ligand across the membrane. We conducted steered molecular dynamics simulations of the GlpT-ligand system to explore how glycerol-3-phosphate would be handled by the “tilted” structure, and obtained results generally consistent with experimental mutagenesis data. While biochemical data remain most consistent with a single-site alternating access model, our results raise the possibility that, while

  16. Typical distribution of the solar erythemal UV radiation over Slovakia

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    A. Pribullová

    2008-03-01

    Full Text Available Maps of the solar erythemal ultraviolet (UV radiation daily doses were created for every month with horizontal resolution of 500 m at geographical domain 47.15 N–49.86 N×16.94 E–22.81 E covering the territory of Slovakia. Cloud modification factor for the UV radiation (cmfUV was modelled utilizing relation between the cmf of total and UV radiation.

    The maps of the cmf factor of the UV radiation were created utilizing measurements of total radiation performed at 9 observatories during 1995–2004 period and the model of cmf dependence on altitude. Maps of clear-sky UV radiation daily dose and UV radiation daily dose affected by average cloudiness were constructed for mean monthly total ozone, their upper and lower monthly limits, for two probability levels of snow cover occurrence as criterion for the snow effect incorporation in the model and for 1 day representing typical values of every month. The map-set can be considered as an atlas of the solar erythemal UV radiation over Slovakia.

  17. Typical distribution of the solar erythemal UV radiation over Slovakia

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    M. Chmelík

    2008-09-01

    Full Text Available Maps of solar erythemal ultraviolet (EUV irradiance daily doses were created for every month with a horizontal resolution of 500 m at the geographical domain 47.15 N–49.86 N×16.94 E–22.81 E covering the territory of Slovakia. The cloud modification factor for the EUV radiation (cmfUV was modeled utilizing the relation between the cloud modification factor of global and EUV radiation. The maps of the cmfUV factor were created by utilizing measurements of global irradiance performed at nine observatories during the period 1995–2004 and modeling of the cmfUV dependence on altitude. Maps of the EUV irradiance daily dose corresponded to clear-sky conditions and EUV irradiance daily dose affected by average cloudiness were constructed for mean monthly total ozone, its upper and lower monthly limits, for two probability levels of snow cover occurrence as criteria for the snow effect incorporation in the model and for one day representing typical values for every month. The map-set can be regarded as an atlas of solar EUV radiation over Slovakia.

  18. A Typical Simulation of a 3-KW Stirling Engine

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    Duan Chen

    2012-10-01

    Full Text Available Stirling engine is being received more and more attention with the development of renewable energy utility. The paper described the design and simulation of a 3-KW Stirling engine based on a testing V-type machine while in the process of manufactured at the Huazhong University of Science and Technology. The engine was driven by solar energy. Based on the testing machine, the heater model of variable heat source, regenerator model and complete appliance model were built, and the thermal performance was simulated and shown under a typical sunlight in the area of Wuhan. The results suggested that the output power curve of Stirling engine appeared as the shape of a saddle in consideration that the radiant energy density of solar energy was non-constant, and electrical heating was employed to serve as the auxiliary heat source. There was about 1.83 KW output work of the manufactured engine during the simulation, and the effective efficiency was about 25.4%.

  19. Parameterization of Evapotranspiration Estimation for Two Typical East Asian Crops

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    Peng Zhao

    2017-06-01

    Full Text Available Estimation of evapotranspiration plays an important role in understanding the water cycle on the earth, especially the water budget in agricultural ecosystems. The parameterization approach of the Penman-Monteith-Katerji-Perrier (PM-KP model, accounting for the influence of meteorological variables and aerodynamic resistance on surface resistance, was proposed in the literature, but it has not been applied to Asian croplands, and its error and sensitivity have not been reported yet. In this study, the estimation of evapotranspiration on half-hourly scale was carried out for two typical East Asian cropland research sites, and evaluated by using eddy-covariance measurements corrected with the energy-balance-closure concept. Sensitivity coefficients as well as systematic bias and random errors of the PM-KP approach were used to evaluate the model performance. Different distributions of the calibration coefficients between different crops were reported for the first time, indicating that the calibration of this model was more stable for the rice field than for the potato field. The commonly-used parameterization approach suggested by the Food and Agriculture Organization (FAO was used as reference and was site-specifically optimized. The results suggest that the PM-KP approach would be a better alternative than the PM-FAO approach for estimating evapotranspiration for the flooded rice field, and an acceptable alternative for rain-fed croplands when the soil is well watered and the air is humid during the summer monsoon.

  20. Genes involved in thoracic exoskeleton formation during the pupal-to-adult molt in a social insect model, Apis mellifera.

    Science.gov (United States)

    Soares, Michelle Prioli Miranda; Barchuk, Angel Roberto; Simões, Ana Carolina Quirino; Dos Santos Cristino, Alexandre; de Paula Freitas, Flávia Cristina; Canhos, Luísa Lange; Bitondi, Márcia Maria Gentile

    2013-08-28

    The insect exoskeleton provides shape, waterproofing, and locomotion via attached somatic muscles. The exoskeleton is renewed during molting, a process regulated by ecdysteroid hormones. The holometabolous pupa transforms into an adult during the imaginal molt, when the epidermis synthe3sizes the definitive exoskeleton that then differentiates progressively. An important issue in insect development concerns how the exoskeletal regions are constructed to provide their morphological, physiological and mechanical functions. We used whole-genome oligonucleotide microarrays to screen for genes involved in exoskeletal formation in the honeybee thoracic dorsum. Our analysis included three sampling times during the pupal-to-adult molt, i.e., before, during and after the ecdysteroid-induced apolysis that triggers synthesis of the adult exoskeleton. Gene ontology annotation based on orthologous relationships with Drosophila melanogaster genes placed the honeybee differentially expressed genes (DEGs) into distinct categories of Biological Process and Molecular Function, depending on developmental time, revealing the functional elements required for adult exoskeleton formation. Of the 1,253 unique DEGs, 547 were upregulated in the thoracic dorsum after apolysis, suggesting induction by the ecdysteroid pulse. The upregulated gene set included 20 of the 47 cuticular protein (CP) genes that were previously identified in the honeybee genome, and three novel putative CP genes that do not belong to a known CP family. In situ hybridization showed that two of the novel genes were abundantly expressed in the epidermis during adult exoskeleton formation, strongly implicating them as genuine CP genes. Conserved sequence motifs identified the CP genes as members of the CPR, Tweedle, Apidermin, CPF, CPLCP1 and Analogous-to-Peritrophins families. Furthermore, 28 of the 36 muscle-related DEGs were upregulated during the de novo formation of striated fibers attached to the exoskeleton. A

  1. An analysis of two-body non-leptonic B decays involving light mesons in the standard model

    CERN Document Server

    Ali, A

    1998-01-01

    We report a theoretical analysis of the exclusive non-leptonic decays of B mesons into two light mesons, some of which have been measured recently by the CLEO collaboration. Our analysis is carried out in the context of an effective Hamiltonian based on the Standard Model (SM), using next-to-leading order perturbative QCD calculations. Using a factorization ansatz for the hadronic matrix elements, we show that existing data are accounted for in this approach. Thus, theoretical scenarios with a substantially enhanced Wilson coefficient of the chromomagnetic dipole operator (as compared to the SM) and/or those with a substantial color-singlet $c\\bar{c}$ component in the wave function of rates, the branching ratios for the decays $B^0 (\\bar{B^0}) \\to \\pi^\\pm experimental limits. Implications of some of these measurements for the parameters of the CKM matrix are presented.

  2. The cell recognition model in chlorolichens involving a fungal lectin binding to an algal ligand can be extended to cyanolichens.

    Science.gov (United States)

    Vivas, M; Sacristán, M; Legaz, M E; Vicente, C

    2010-07-01

    Leptogium corniculatum, a cyanolichen containing Nostoc as photobiont, produces and secretes arginase to culture medium containing arginine. This secreted arginase was pre-purified by affinity chromatography on beads of activated agarose to which a polygalactosylated urease, purified from Evernia prunastri, was attached. Arginase was eluted from the beads with 50 mm alpha-d-galactose. The eluted arginase binds preferentially to the cell surface of Nostoc isolated from this lichen thallus, although it is also able to bind, to some extent, to the cell surface of the chlorobiont isolated from E. prunastri. Previous studies in chlorolichens have shown that a fungal lectin that develops subsidiary arginase activity can be a factor in recognition of compatible algal cells through binding to a polygalactosylated urease, which acts as a lectin ligand in the algal cell wall. Our experiments demonstrate that this model can now be extended to cyanolichens.

  3. Dorsal anterior cingulate cortex in typically developing children: Laterality analysis

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    Jue Wang

    2015-10-01

    Full Text Available We aimed to elucidate the dACC laterality in typically developing children and their sex/age-related differences with a sample of 84 right-handed children (6–16 years, 42 boys. We first replicated the previous finding observed in adults that gray matter density asymmetry in the dACC was region-specific: leftward (left > right in its superior part, rightward (left < right in its inferior part. Intrinsic connectivity analysis of these regions further revealed region-specific asymmetric connectivity profiles in dACC as well as their sex and age differences. Specifically, the superior dACC connectivity with frontoparietal network and the inferior dACC connectivity with visual network are rightward. The superior dACC connectivity with the default network (lateral temporal cortex was more involved in the left hemisphere. In contrast, the inferior dACC connectivity with the default network (anterior medial prefrontal cortex was more lateralized towards the right hemisphere. The superior dACC connectivity with lateral visual cortex was more distinct across two hemispheres in girls than that in boys. This connection in boys changed with age from right-prominent to left-prominent asymmetry whereas girls developed the connection from left-prominent to no asymmetry. These findings not only highlight the complexity and laterality of the dACC but also provided insights into dynamical structure–function relationships during the development.

  4. Dorsal anterior cingulate cortex in typically developing children: Laterality analysis.

    Science.gov (United States)

    Wang, Jue; Yang, Ning; Liao, Wei; Zhang, Han; Yan, Chao-Gan; Zang, Yu-Feng; Zuo, Xi-Nian

    2015-10-01

    We aimed to elucidate the dACC laterality in typically developing children and their sex/age-related differences with a sample of 84 right-handed children (6-16 years, 42 boys). We first replicated the previous finding observed in adults that gray matter density asymmetry in the dACC was region-specific: leftward (left > right) in its superior part, rightward (left lateral temporal cortex) was more involved in the left hemisphere. In contrast, the inferior dACC connectivity with the default network (anterior medial prefrontal cortex) was more lateralized towards the right hemisphere. The superior dACC connectivity with lateral visual cortex was more distinct across two hemispheres in girls than that in boys. This connection in boys changed with age from right-prominent to left-prominent asymmetry whereas girls developed the connection from left-prominent to no asymmetry. These findings not only highlight the complexity and laterality of the dACC but also provided insights into dynamical structure-function relationships during the development.

  5. Comparison of typical mega cities in China using emergy synthesis

    Science.gov (United States)

    Zhang, L. X.; Chen, B.; Yang, Z. F.; Chen, G. Q.; Jiang, M. M.; Liu, G. Y.

    2009-06-01

    An emergy-based comparison analysis is conducted for three typical mega cities in China, i.e., Beijing, Shanghai and Guangzhou, from 1990 to 2005 in four perspectives including emergy intensity, resource structure, environmental pressure and resource use efficiency. A new index of non-renewable emergy/money ratio is established to indicate the utilization efficiency of the non-renewable resources. The results show that for the three mega urban systems, Beijing, Shanghai and Guangzhou, the total emergy inputs were 3.76E+23, 3.54E+23, 2.52E+23 sej in 2005, of which 64.88%, 91.45% and 72.28% were imported from the outsides, respectively. As to the indicators of emergy intensity involving the total emergy use, emergy density and emergy use per cap, three cities exhibited similar overall increase trends with annual fluctuations from 1990 to 2005. Shanghai achieved the highest level of economic development and non-renewable resource use efficiency, and meanwhile, lower proportion of renewable resource use and higher environmental pressure compared to those of Beijing and Guangzhou. Guangzhou has long term sustainability considering an amount of local renewable resources used, per capita emergy used, energy consumption per unit GDP and the ratio of waste to renewable emergy. It can be concluded that different emergy-based evaluation results arise from different geographical locations, resources endowments, industrial structures and urban orientations of the concerned mega cities.

  6. Molecular phylogenetics and comparative modeling of HEN1, a methyltransferase involved in plant microRNA biogenesis

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    Obarska Agnieszka

    2006-01-01

    Full Text Available Abstract Background Recently, HEN1 protein from Arabidopsis thaliana was discovered as an essential enzyme in plant microRNA (miRNA biogenesis. HEN1 transfers a methyl group from S-adenosylmethionine to the 2'-OH or 3'-OH group of the last nucleotide of miRNA/miRNA* duplexes produced by the nuclease Dicer. Previously it was found that HEN1 possesses a Rossmann-fold methyltransferase (RFM domain and a long N-terminal extension including a putative double-stranded RNA-binding motif (DSRM. However, little is known about the details of the structure and the mechanism of action of this enzyme, and about its phylogenetic origin. Results Extensive database searches were carried out to identify orthologs and close paralogs of HEN1. Based on the multiple sequence alignment a phylogenetic tree of the HEN1 family was constructed. The fold-recognition approach was used to identify related methyltransferases with experimentally solved structures and to guide the homology modeling of the HEN1 catalytic domain. Additionally, we identified a La-like predicted RNA binding domain located C-terminally to the DSRM domain and a domain with a peptide prolyl cis/trans isomerase (PPIase fold, but without the conserved PPIase active site, located N-terminally to the catalytic domain. Conclusion The bioinformatics analysis revealed that the catalytic domain of HEN1 is not closely related to any known RNA:2'-OH methyltransferases (e.g. to the RrmJ/fibrillarin superfamily, but rather to small-molecule methyltransferases. The structural model was used as a platform to identify the putative active site and substrate-binding residues of HEN and to propose its mechanism of action.

  7. Application of a random effects negative binomial model to examine tram-involved crash frequency on route sections in Melbourne, Australia.

    Science.gov (United States)

    Naznin, Farhana; Currie, Graham; Logan, David; Sarvi, Majid

    2016-07-01

    Safety is a key concern in the design, operation and development of light rail systems including trams or streetcars as they impose crash risks on road users in terms of crash frequency and severity. The aim of this study is to identify key traffic, transit and route factors that influence tram-involved crash frequencies along tram route sections in Melbourne. A random effects negative binomial (RENB) regression model was developed to analyze crash frequency data obtained from Yarra Trams, the tram operator in Melbourne. The RENB modelling approach can account for spatial and temporal variations within observation groups in panel count data structures by assuming that group specific effects are randomly distributed across locations. The results identify many significant factors effecting tram-involved crash frequency including tram service frequency (2.71), tram stop spacing (-0.42), tram route section length (0.31), tram signal priority (-0.25), general traffic volume (0.18), tram lane priority (-0.15) and ratio of platform tram stops (-0.09). Findings provide useful insights on route section level tram-involved crashes in an urban tram or streetcar operating environment. The method described represents a useful planning tool for transit agencies hoping to improve safety performance.

  8. SOCIAL AND NON-SOCIAL CUEING OF VISUOSPATIAL ATTENTION IN AUTISM AND TYPICAL DEVELOPMENT

    Science.gov (United States)

    Pruett, John R.; LaMacchia, Angela; Hoertel, Sarah; Squire, Emma; McVey, Kelly; Todd, Richard D.; Constantino, John N.; Petersen, Steven E.

    2013-01-01

    Three experiments explored attention to eye gaze, which is incompletely understood in typical development and is hypothesized to be disrupted in autism. Experiment 1 (n=26 typical adults) involved covert orienting to box, arrow, and gaze cues at two probabilities and cue-target times to test whether reorienting for gaze is endogenous, exogenous, or unique; experiment 2 (total n=80: male and female children and adults) studied age and sex effects on gaze cueing. Gaze cueing appears endogenous and may strengthen in typical development. Experiment 3 tested exogenous, endogenous, and/or gaze-based orienting in 25 typical and 27 Autistic Spectrum Disorder (ASD) children. ASD children made more saccades, slowing their reaction times; however, exogenous and endogenous orienting, including gaze cueing, appear intact in ASD. PMID:20809377

  9. Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α

    Directory of Open Access Journals (Sweden)

    Esposito Emanuela

    2012-04-01

    Full Text Available Abstract Background Statins such as simvastatin are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA reductase used in the prevention of cardiovascular disease. In addition to their cholesterol-lowering activities, statins exert pleiotropic anti-inflammatory effects, which might contribute to their beneficial effects on lipid-unrelated inflammatory diseases. Recently it has been demonstrated that the peroxisome proliferator-activated receptor (PPAR-α mediates anti-inflammatory effects of simvastatin in vivo models of acute inflammation. Moreover, previous results suggest that PPAR-α plays a role in control of secondary inflammatory process associated with spinal cord injury (SCI. Methods With the aim to characterize the role of PPAR-α in simvastatin activity, we tested the efficacy of simvastatin (10 mg/kg dissolved in saline i.p. 1 h and 6 h after the trauma in an experimental model of SCI induced in mice by extradural compression of the spinal cord (T6-T7 level using an aneurysm clip with a closing force of 24 g via a four-level T5-T8 laminectomy, and comparing mice lacking PPAR-α (PPAR-α KO with wild type (WT mice. In order to elucidate whether the effects of simvastatin are due to activation of the PPAR-α, we also investigated the effect of a PPAR-α antagonist, GW6471 (1 mg/kg administered i.p. 30 min prior treatment with simvastatin on the protective effects of on simvastatin. Results Results indicate that simvastatin activity is weakened in PPAR-α KO mice, as compared to WT controls. In particular, simvastatin was less effective in PPAR-α KO, compared to WT mice, as evaluated by inhibition of the degree of spinal cord inflammation, neutrophil infiltration, nitrotyrosine formation, pro-inflammmatory cytokine expression, nuclear factor (NF-κB activation, inducible nitric-oxide synthase (iNOS expression, and apoptosis. In addition we demonstrated that GW6471 significantly antagonized the effect of the statin and thus

  10. Structure and Coherence of Reasoning Ability in Down Syndrome Adults and Typically Developing Children.

    Science.gov (United States)

    Natsopoulos, D.; Christou, C.; Koutselini, M.; Raftopoulos, A.; Karefillidou, C.

    2002-01-01

    A study involving 31 adults with Down syndrome investigated their ability to reason. Results found they did not differ from typically developing children, matched on expressive and verbal ability, in transitivity and non-verbal analogical thinking; however, they did differ in categorical reasoning, classical verbal analogies, and short-term…

  11. Reading under the Skin: Physiological Activation during Reading in Children with Dyslexia and Typical Readers

    Science.gov (United States)

    Tobia, Valentina; Bonifacci, Paola; Ottaviani, Cristina; Borsato, Thomas; Marzocchi, Gian Marco

    2016-01-01

    The aim of this study was to investigate physiological activation during reading and control tasks in children with dyslexia and typical readers. Skin conductance response (SCR) recorded during four tasks involving reading aloud, reading silently, and describing illustrated stories aloud and silently was compared for children with dyslexia (n =…

  12. Finding biomarkers in non-model species: literature mining of transcription factors involved in bovine embryo development

    Directory of Open Access Journals (Sweden)

    Turenne Nicolas

    2012-08-01

    Full Text Available Abstract Background Since processes in well-known model organisms have specific features different from those in Bos taurus, the organism under study, a good way to describe gene regulation in ruminant embryos would be a species-specific consideration of closely related species to cattle, sheep and pig. However, as highlighted by a recent report, gene dictionaries in pig are smaller than in cattle, bringing a risk to reduce the gene resources to be mined (and so for sheep dictionaries. Bioinformatics approaches that allow an integration of available information on gene function in model organisms, taking into account their specificity, are thus needed. Besides these closely related and biologically relevant species, there is indeed much more knowledge of (i trophoblast proliferation and differentiation or (ii embryogenesis in human and mouse species, which provides opportunities for reconstructing proliferation and/or differentiation processes in other mammalian embryos, including ruminants. The necessary knowledge can be obtained partly from (i stem cell or cancer research to supply useful information on molecular agents or molecular interactions at work in cell proliferation and (ii mouse embryogenesis to supply useful information on embryo differentiation. However, the total number of publications for all these topics and species is great and their manual processing would be tedious and time consuming. This is why we used text mining for automated text analysis and automated knowledge extraction. To evaluate the quality of this “mining”, we took advantage of studies that reported gene expression profiles during the elongation of bovine embryos and defined a list of transcription factors (or TF, n = 64 that we used as biological “gold standard”. When successful, the “mining” approach would identify them all, as well as novel ones. Methods To gain knowledge on molecular-genetic regulations in a non model organism, we offer an

  13. Phenylpyrazole insecticides induce cytotoxicity by altering mechanisms involved in cellular energy supply in the human epithelial cell model Caco-2.

    Science.gov (United States)

    Vidau, Cyril; Brunet, Jean-Luc; Badiou, Alexandra; Belzunces, Luc P

    2009-06-01

    Phenylpyrazoles are relatively new insecticides designed to manage problematic insect resistance and public health hazards encountered with older pesticide families. In vitro cytotoxicity induced by the phenylpyrazole insecticides, Ethiprol and Fipronil, and Fipronil metabolites, sulfone and sulfide, was studied in Caco-2 cells. This cellular model was chosen because it made possible to mimic the primary site of oral exposure to xenobiotics, the intestinal epithelium. Assessment of the barrier function of Caco-2 epithelium was assessed by TEER measurement and showed a major loss of barrier integrity after exposure to Fipronil and its metabolites, but not to Ethiprol. The disruption of the epithelial barrier was attributed to severe ATP depletion independent of cell viability, as revealed by LDH release. The origin of energetic metabolism failure was investigated and revealed a transient enhancement of tetrazolium salt reduction and an increase in lactate production by Caco-2 cells, suggesting an increase in glucose metabolism by pesticides. Cellular symptoms observed in these experiments lead us to hypothesize that phenylpyrazole insecticides interacted with mitochondria.

  14. Damage of polyesters by the atmospheric free radical oxidant NO3•: a product study involving model systems

    Directory of Open Access Journals (Sweden)

    Catrin Goeschen

    2013-09-01

    Full Text Available Manufactured polymer materials are used in increasingly demanding applications, but their lifetime is strongly influenced by environmental conditions. In particular, weathering and ageing leads to dramatic changes in the properties of the polymers, which results in decreased service life and limited usage. Despite the heavy reliance of our society on polymers, the mechanism of their degradation upon exposure to environmental oxidants is barely understood. In this work, model systems of important structural motifs in commercial high-performing polyesters were used to study the reaction with the night-time free radical oxidant NO3• in the absence and presence of other radical and non-radical oxidants. Identification of the products revealed ‘hot spots’ in polyesters that are particularly vulnerable to attack by NO3• and insight into the mechanism of oxidative damage by this environmentally important radical. It is suggested that both intermediates as well as products of these reactions are potentially capable of promoting further degradation processes in polyesters under environmental conditions.

  15. Damage of polyesters by the atmospheric free radical oxidant NO3 (•): a product study involving model systems.

    Science.gov (United States)

    Goeschen, Catrin; Wille, Uta

    2013-01-01

    Manufactured polymer materials are used in increasingly demanding applications, but their lifetime is strongly influenced by environmental conditions. In particular, weathering and ageing leads to dramatic changes in the properties of the polymers, which results in decreased service life and limited usage. Despite the heavy reliance of our society on polymers, the mechanism of their degradation upon exposure to environmental oxidants is barely understood. In this work, model systems of important structural motifs in commercial high-performing polyesters were used to study the reaction with the night-time free radical oxidant NO3 (•) in the absence and presence of other radical and non-radical oxidants. Identification of the products revealed 'hot spots' in polyesters that are particularly vulnerable to attack by NO3 (•) and insight into the mechanism of oxidative damage by this environmentally important radical. It is suggested that both intermediates as well as products of these reactions are potentially capable of promoting further degradation processes in polyesters under environmental conditions.

  16. Anti-Inflammatory Effect of Emblica officinalis in Rodent Models of Acute and Chronic Inflammation: Involvement of Possible Mechanisms

    Directory of Open Access Journals (Sweden)

    Mahaveer Golechha

    2014-01-01

    Full Text Available Emblica officinalis, commonly known as amla in Ayurveda, is unarguably the most important medicinal plant for prevention and treatment of various ailments. The present study investigated the anti-inflammatory activity of hydroalcoholic extract of Emblica officinalis (HAEEO. Acute inflammation in rats was induced by the subplantar injection of carrageenan, histamine, serotonin, and prostaglandin E2 and chronic inflammation was induced by the cotton pellet granuloma. Intraperitoneal (i.p. administration of HAEEO at all the tested doses (300, 500, and 700 mg/kg significantly (P<0.001 inhibited rat paw edema against all phlogistic agents and also reduced granuloma formation. However, at the dose of 700 mg/kg, HAEEO exhibited maximum anti-inflammatory activity in all experimental models, and the effects were comparable to that of the standard anti-inflammatory drugs. Additionally, in paw tissue the antioxidant activity of HAEEO was also measured and it was found that HAEEO significantly (P<0.001 increased glutathione, superoxide dismutase, and catalase activity and subsequently reduced lipid peroxidation evidenced by reduced malondialdehyde. Taken all together, the results indicated that HAEEO possessed potent anti-inflammatory activity and it may hold therapeutic promise in the management of acute and chronic inflammatory conditions.

  17. Uric Acid Amplifies Aβ Amyloid Effects Involved in the Cognitive Dysfunction/Dementia: Evidences From an Experimental Model In Vitro.

    Science.gov (United States)

    Desideri, Giovambattista; Gentile, Roberta; Antonosante, Andrea; Benedetti, Elisabetta; Grassi, Davide; Cristiano, Loredana; Manocchio, Antonello; Selli, Sara; Ippoliti, Rodolfo; Ferri, Claudio; Borghi, Claudio; Giordano, Antonio; Cimini, Annamaria

    2017-05-01

    There is still a considerable debate concerning whether uric acid is neuroprotective or neurotoxic agent. To clarify this topic, we tested the effects of uric acid on neuronal cells biology by using differentiated SHSY5Y neuroblastoma cells incubated with amyloid β to reproduce an in vitro model of Alzheimer's disease. The incubation of cells with uric acid at the dose of 40 µM or higher significantly reduced cell viability and potentiated the proapoptotic effect of amyloid β. Finally, uric acid enhanced the generation of 4-hydroxynonenal and the expression of PPARβ/δ promoted by amyloid β, indicating a prooxidant effects. In conclusion, uric acid could exert a detrimental influence on neuronal biology being this influence further potentiated by the concomitant exposure to neurotoxic stimuli. This effect is evident for uric acid concentrations close to those achievable in cerebrospinal fluid in presence of mild hyperuricemia thus suggesting a potential role of uric acid in pathophysiology of cognitive dysfunction. These effects are influenced by the concentrations of uric acid and by the presence of favoring conditions that commonly occur in neurodegenerative disorders and well as in the aging brain, including increased oxidative stress and exposure to amyloid β. J. Cell. Physiol. 232: 1069-1078, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  18. Riluzole neuroprotection in a parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation

    Directory of Open Access Journals (Sweden)

    Carbone Marica

    2012-04-01

    Full Text Available Abstract Background Riluzole is a neuroprotective drug used in the treatment of motor neurone disease. Recent evidence suggests that riluzole can up-regulate the expression and activity of the astrocyte glutamate transporter, GLT-1. Given that regulation of glutamate transport is predicted to be neuroprotective in Parkinson's disease, we tested the effect of riluzole in parkinsonian rats which had received a unilateral 6-hydroxydopamine injection into the median forebrain bundle. Results Rats were treated with intraperitoneal riluzole (4 mg/kg or 8 mg/kg, 1 hour before the lesion then once daily for seven days. Riluzole produced a modest but significant attenuation of dopamine neurone degeneration, assessed by suppression of amphetamine-induced rotations, preservation of tyrosine hydroxylase positive neuronal cell bodies in the substantia nigra pars compacta and attenuation of striatal tyrosine hydroxylase protein loss. Seven days after 6-hydroxydopamine lesion, reactive astrocytosis was observed in the striatum, as determined by increases in expression of glial fibrillary acidic protein, however the glutamate transporter, GLT-1, which is also expressed in astrocytes was not regulated by the lesion. Conclusions The results confirm that riluzole is a neuroprotective agent in a rodent model of parkinson's disease. Riluzole administration did not regulate GLT-1 levels but significantly reduced GFAP levels, in the lesioned striatum. Riluzole suppression of reactive astrocytosis is an intriguing finding which might contribute to the neuroprotective effects of this drug.

  19. A Typical Case Study: Solid Waste Management in Petroleum Refineries

    Directory of Open Access Journals (Sweden)

    Jadea S. Alshammari

    2008-01-01

    Full Text Available The current environmental concerns have forced developed and developing countries to reduce air, water and land pollution for sustainable growth. Solid refinery waste is cocktail of hydrocarbons, water, heavy metal and fine solids and is substantial in quantity. The principal processes of waste management focus mainly on waste source reduction, reusing, recycling, composting, incineration with or without energy recovery, fuel production and land filling. Waste management models have a common approach of assignment of generating sources to landfills, transfer stations sitting, site selection for landfills, etc. but recently new integrated models have been developed and applied. Waste management system in an industrial complexes uses multi-objective mixed integer programming approach for the running of existing facilities in dynamic net work flow models with nonlinear costs of management. The latest multi-objective mixed integer programming techniques are applied to resolve the potential conflict between environmental and economic goals and to evaluate sustainable strategies for waste management. In this approach, material recycling in an economic sense exhibits huge indirect benefits, although the emphasis of environmental quality as a major objective in decision-making drives the optimal solution toward pro-recycling programs. The use of grey and fuzzy system theories as uncertainty analysis tools as an enhancement of this modeling analysis proves to be highly profitable. A multi-objective optimization model based on the goal programming approach has been developed and tested in this study for passable management of solid waste generated by a typical petroleum refining industry in the state of Kuwait. The analytic hierarchy process, a decision-making approach, including qualitative and quantitative aspects of a problem, has been integrated in the model to prioritize the conflicting goals existing in the waste management problems of the petroleum

  20. Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression

    KAUST Repository

    Meylan, E M

    2016-07-12

    Recent studies implicate the arginine-decarboxylation product agmatine in mood regulation. Agmatine has antidepressant properties in rodent models of depression, and agmatinase (Agmat), the agmatine-degrading enzyme, is upregulated in the brains of mood disorder patients. We have previously shown that mice lacking CREB-regulated transcription coactivator 1 (CRTC1) associate behavioral and molecular depressive-like endophenotypes, as well as blunted responses to classical antidepressants. Here, the molecular basis of the behavioral phenotype of Crtc1−/− mice was further examined using microarray gene expression profiling that revealed an upregulation of Agmat in the cortex of Crtc1−/− mice. Quantitative polymerase chain reaction and western blot analyses confirmed Agmat upregulation in the Crtc1−/− prefrontal cortex (PFC) and hippocampus, which were further demonstrated by confocal immunofluorescence microscopy to comprise an increased number of Agmat-expressing cells, notably parvalbumin- and somatostatin-positive interneurons. Acute agmatine and ketamine treatments comparably improved the depressive-like behavior of male and female Crtc1−/− mice in the forced swim test, suggesting that exogenous agmatine has a rapid antidepressant effect through the compensation of agmatine deficit because of upregulated Agmat. Agmatine rapidly increased brain-derived neurotrophic factor (BDNF) levels only in the PFC of wild-type (WT) females, and decreased eukaryotic elongation factor 2 (eEF2) phosphorylation in the PFC of male and female WT mice, indicating that agmatine might be a fast-acting antidepressant with N-methyl-D-aspartate (NMDA) receptor antagonist properties. Collectively, these findings implicate Agmat in the depressive-like phenotype of Crtc1−/− mice, refine current understanding of the agmatinergic system in the brain and highlight its putative role in major depression.

  1. Disruption of social cognition in the sub-chronic PCP rat model of schizophrenia: Possible involvement of the endocannabinoid system.

    Science.gov (United States)

    Seillier, Alexandre; Giuffrida, Andrea

    2016-02-01

    Previous studies have shown that social withdrawal in the phencyclidine (PCP) rat model of schizophrenia results from deficient endocannabinoid-induced activation of CB1 receptors. To understand the underlying cognitive mechanisms of the social deficit in PCP-treated rats, we examined the impact of pharmacological manipulation of the endocannabinoid system on sociability (i.e. social approach) and social novelty preference (which relies on social recognition). Control rats showed a clear preference for a "social" cage (i.e. unfamiliar stimulus rat placed under a wire mesh cage) versus an "empty" cage, and spent more time exploring a "novel" cage (i.e. new stimulus rat) versus a "familiar" cage. In contrast, rats receiving PCP (5 mg/kg, b.i.d. for 7 days, followed by a 7 day-washout period) showed intact sociability, but lacked social novelty preference. This PCP-induced deficit was due to increased activity at CB1 receptors as it was reversed by systemic administration of the CB1 antagonist AM251 (1 mg/kg). In agreement with this hypothesis, the cannabinoid agonist CP55,940 (0.003-0.03 mg/kg) dose-dependently suppressed social novelty preference in control animals without affecting sociability. Taken together, these data suggest that PCP-treated rats have a deficit in social cognition, possibly induced by increased stimulation of CB1 receptors. This deficit, however, is distinct from the social withdrawal previously observed in these animals, as the latter is due to deficient, rather than increased, CB1 stimulation. Copyright © 2015 Elsevier B.V. and ECNP. All rights reserved.

  2. Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression.

    Science.gov (United States)

    Meylan, E M; Breuillaud, L; Seredenina, T; Magistretti, P J; Halfon, O; Luthi-Carter, R; Cardinaux, J-R

    2016-07-12

    Recent studies implicate the arginine-decarboxylation product agmatine in mood regulation. Agmatine has antidepressant properties in rodent models of depression, and agmatinase (Agmat), the agmatine-degrading enzyme, is upregulated in the brains of mood disorder patients. We have previously shown that mice lacking CREB-regulated transcription coactivator 1 (CRTC1) associate behavioral and molecular depressive-like endophenotypes, as well as blunted responses to classical antidepressants. Here, the molecular basis of the behavioral phenotype of Crtc1(-/-) mice was further examined using microarray gene expression profiling that revealed an upregulation of Agmat in the cortex of Crtc1(-/-) mice. Quantitative polymerase chain reaction and western blot analyses confirmed Agmat upregulation in the Crtc1(-/-) prefrontal cortex (PFC) and hippocampus, which were further demonstrated by confocal immunofluorescence microscopy to comprise an increased number of Agmat-expressing cells, notably parvalbumin- and somatostatin-positive interneurons. Acute agmatine and ketamine treatments comparably improved the depressive-like behavior of male and female Crtc1(-/-) mice in the forced swim test, suggesting that exogenous agmatine has a rapid antidepressant effect through the compensation of agmatine deficit because of upregulated Agmat. Agmatine rapidly increased brain-derived neurotrophic factor (BDNF) levels only in the PFC of wild-type (WT) females, and decreased eukaryotic elongation factor 2 (eEF2) phosphorylation in the PFC of male and female WT mice, indicating that agmatine might be a fast-acting antidepressant with N-methyl-D-aspartate (NMDA) receptor antagonist properties. Collectively, these findings implicate Agmat in the depressive-like phenotype of Crtc1(-/-) mice, refine current understanding of the agmatinergic system in the brain and highlight its putative role in major depression.

  3. Guanosine tetraphosphate as a global regulator of bacterial RNA synthesis: a model involving RNA polymerase pausing and queuing.

    Science.gov (United States)

    Bremer, H; Ehrenberg, M

    1995-05-17

    A recently reported comparison of stable RNA (rRNA, tRNA) and mRNA synthesis rates in ppGpp-synthesizing and ppGpp-deficient (delta relA delta spoT) bacteria has suggested that ppGpp inhibits transcription initiation from stable RNA promoters, as well as synthesis of (bulk) mRNA. Inhibition of stable RNA synthesis occurs mainly during slow growth of bacteria when cytoplasmic levels of ppGpp are high. In contrast, inhibition of mRNA occurs mainly during fast growth when ppGpp levels are low, and it is associated with a partial inactivation of RNA polymerase. To explain these observations it has been proposed that ppGpp causes transcriptional pausing and queuing during the synthesis of mRNA. Polymerase queuing requires high rates of transcription initiation in addition to polymerase pausing, and therefore high concentrations of free RNA polymerase. These conditions are found in fast growing bacteria. Furthermore, the RNA polymerase queues lead to a promoter blocking when RNA polymerase molecules stack up from the pause site back to the (mRNA) promoter. This occurs most frequently at pause sites close to the promoter. Blocking of mRNA promoters diverts RNA polymerase to stable RNA promoters. In this manner ppGpp could indirectly stimulate synthesis of stable RNA at high growth rates. In the present work a mathematical analysis, based on the theory of queuing, is presented and applied to the global control of transcription in bacteria. This model predicts the in vivo distribution of RNA polymerase over stable RNA and mRNA genes for both ppGpp-synthesizing and ppGpp-deficient bacteria in response to different environmental conditions. It also shows how small changes in basal ppGpp concentrations can produce large changes in the rate of stable RNA synthesis.

  4. Involvement of necroptosis, a newly recognized cell death type, in steroid-induced osteonecrosis in a rabbit model

    Science.gov (United States)

    Ichiseki, Toru; Ueda, Shusuke; Ueda, Yoshimichi; Tuchiya, Masanobu; Kaneuji, Ayumi; Kawahara, Norio

    2017-01-01

    We investigated the role of programmed necrosis (necroptosis), a newly recognized form of cell necrosis that has been implicated in the development of steroid-induced osteonecrosis. We used an osteonecrosis model in which 30 Japanese white rabbits each weighing 3.5kg were injected once with methylprednisolone at 20 mg/kg body weight into the right gluteal muscle. Ten animals killed 14 days thereafter were designated as S14d groups, while another 10 animals injected with necroptosis, a specific inhibitor of necrostatin-1 i.v. at 1.65mg/kg on the same day as the steroid were also killed on the 14th day and designated as SN14d group. As a control, 10 animals injected only with physiological saline were studied as N group. After the animals were sacrificed the bilateral femoral bone was examined histopathologically and the presence of osteonecrosis determined. Furthermore, animals subjected to the same treatment and killed on the 3rd day after drug administration were set up as S3d group and SN3d group, and Western blotting of Receptor-interacting protein ( RIP ) 1 and RIP3 in femoral bone performed. The osteonecrosis rate was 70% in S14d group, and 0% in both N and SN groups. In 2 of 10 animals in SN group fatty marrow was found. On Western blotting significantly increased expression of both RIP1 and RIP3 was noted in S3d group, confirming that Nec-1 was suppressed. Necroptosis mediated by RIP1 and RIP3 expression was thought to be implicated in the development of steroid-induced osteonecrosis. Also, by suppressing expression of RIP1 and 3 with the administration of Nec-1 the osteonecrosis rate was significantly decreased. These results suggest that necroptosis may have potential as a novel target for both elucidating the mechanisms underlying steroid-induced osteonecrosis and establishing more effective prophylactic countermeasures. PMID:28260985

  5. BDNF prevents NMDA-induced toxicity in models of Huntington's disease: the effects are genotype specific and adenosine A2A receptor is involved.

    Science.gov (United States)

    Martire, Alberto; Pepponi, Rita; Domenici, Maria Rosaria; Ferrante, Antonella; Chiodi, Valentina; Popoli, Patrizia

    2013-04-01

    NMDA receptor-mediated excitotoxicity is thought to play a pivotal role in the pathogenesis of Huntington's disease (HD). The neurotrophin brain-derived neurotrophic factor (BDNF), which is also highly involved in HD and whose effects are modulated by adenosine A2 ARs, influences the activity and expression of striatal NMDA receptors. In electrophysiology experiments, we investigated the role of BDNF toward NMDA-induced effects in HD models, and the possible involvement of A2ARs. In corticostriatal slices from wild-type mice and age-matched symptomatic R6/2 mice (a model of HD), NMDA application (75 μM) induced a transient or a permanent (i.e., toxic) reduction of field potential amplitude, respectively. BDNF (10 ng/mL) potentiated NMDA effects in wild-type, while it protected from NMDA toxicity in R6/2 mice. Both effects of BDNF were prevented by A2 AR blockade. The protective effect of BDNF against NMDA-induced toxicity was reproduced in a cellular model of HD. These findings may have very important implications for the neuroprotective potential of BDNF and A2 AR ligands in HD.

  6. Structure of executive functions in typically developing kindergarteners.

    Science.gov (United States)

    Monette, Sébastien; Bigras, Marc; Lafrenière, Marc-André

    2015-12-01

    Whereas studies of the past 10 years have shown the executive functions (EFs) in adults to be differentiated into at least three principal components (working memory, inhibition, and flexibility), EF structure in children is far less well understood despite a large body of research on the subject. A study was undertaken to test different structural models of EFs through confirmatory factor analysis (CFA) on a large sample of typically developing kindergarteners (N = 272). The method employed sought to remedy the shortcomings of past research in this field such as absence of CFA, insufficient number of EF components tested, insufficient number of indicators per latent variable, and absence of control on processing speed. Children were assessed using a battery of EF tasks developed by the researchers to measure working memory (WM), flexibility, and inhibition (backward word span, backward block span, fruit Stroop, day-night test, hand Stroop, Trails-P, card sort, face sort, and verbal fluency shift). CFA results show the best-fitting model to comprise two factors, namely, an inhibition factor and a WM-flexibility factor. Invariance analyses suggest that this structure is the same for girls and boys and that latent variable means do not differ by sex. These results support the hypothesis of EF differentiation during development. The researchers formulate other hypotheses regarding neurophysiological development.

  7. Typical Lignocellulose-degrading Enzymes: a Synthesis of Kinetic Properties

    Science.gov (United States)

    Wang, G.; Post, W. M.; Mayes, M. A.; Frerichs, J.; Jagadamma, S.

    2011-12-01

    While soil enzymes have been explicitly included in the soil organic carbon (SOC) decomposition models, there are big concerns on the model parameterization. Our object is to study the kinetic parameters of five typical lignocellulose-degrading enzymes through literature research and data synthesis. The kinetic parameters refer to the maximum specific enzyme activity (Vmax) and half-saturation constant (Km) in the Michaelis-Menton equation. The Activation energy (Ea) and the pH optimum and sensitivity (pHopt and pHsen) were also analyzed. pHsen was estimated by curve fitting of an exponential-quadratic function. The Vmax values in different units under various conditions were converted into the same units at a reference temperature (20°C) and optimum pH. The scaling issue on Vmax and Km and the effects of soil temperature, pH, and SWC were discussed later. Major findings are summarized as follows. (i) Both Vmax and Km are log-normal distributed. (ii) No significant difference in Vmax is found between groups (ligninases and cellulases). The one-standard-deviation interval of Vmax falls within 10-1000 (mean ≈ 100) mg C mg^-1 Enz h^-1. However, there is significant difference in Km between groups. (iii) Significant difference in activation energy, i.e., 53±17 and 37±15 kJ mol^-1 is found for ligninases and cellulases, respectively. (iv) Both ligninases and cellulases prefer to acid environment. The average ratio of pHsen to pHopt ranges 0.3-0.4 and the optimum pH for ligninases is significantly lower than pHopt for cellulases. (v) A preliminary analysis of Vmax indicates a scaling factor 0.01-0.1 for transforming the Vmax from lab measurements to SOC decomposition models. This study provides useful information for the parameterization of enzyme-driven SOC decomposition models.

  8. Typical pure nonequilibrium steady states and irreversibility for quantum transport.

    Science.gov (United States)

    Monnai, Takaaki; Yuasa, Kazuya

    2016-07-01

    It is known that each single typical pure state in an energy shell of a large isolated quantum system well represents a thermal equilibrium state of the system. We show that such typicality holds also for nonequilibrium steady states (NESS's). We consider a small quantum system coupled to multiple infinite reservoirs. In the long run, the total system reaches a unique NESS. We identify a large Hilbert space from which pure states of the system are to be sampled randomly and show that the typical pure states well describe the NESS. We also point out that the irreversible relaxation to the unique NESS is important to the typicality of the pure NESS's.

  9. Typical pure nonequilibrium steady states and irreversibility for quantum transport

    Science.gov (United States)

    Monnai, Takaaki; Yuasa, Kazuya

    2016-07-01

    It is known that each single typical pure state in an energy shell of a large isolated quantum system well represents a thermal equilibrium state of the system. We show that such typicality holds also for nonequilibrium steady states (NESS's). We consider a small quantum system coupled to multiple infinite reservoirs. In the long run, the total system reaches a unique NESS. We identify a large Hilbert space from which pure states of the system are to be sampled randomly and show that the typical pure states well describe the NESS. We also point out that the irreversible relaxation to the unique NESS is important to the typicality of the pure NESS's.

  10. Across frequency processes involved in auditory detection of coloration

    DEFF Research Database (Denmark)

    Buchholz, Jörg; Kerketsos, P

    2008-01-01

    When an early wall reflection is added to a direct sound, a spectral modulation is introduced to the signal's power spectrum. This spectral modulation typically produces an auditory sensation of coloration or pitch. Throughout this study, auditory spectral-integration effects involved in coloration...... detection are investigated. Coloration detection thresholds were therefore measured as a function of reflection delay and stimulus bandwidth. In order to investigate the involved auditory mechanisms, an auditory model was employed that was conceptually similar to the peripheral weighting model [Yost, JASA......, 1982, 416-425]. When a “classical” gammatone filterbank was applied within this spectrum-based model, the model largely underestimated human performance at high signal frequencies. However, this limitation could be resolved by employing an auditory filterbank with narrower filters. This novel...

  11. Multiple solutions and numerical analysis to the dynamic and stationary models coupling a delayed energy balance model involving latent heat and discontinuous albedo with a deep ocean.

    Science.gov (United States)

    Díaz, J I; Hidalgo, A; Tello, L

    2014-10-08

    We study a climatologically important interaction of two of the main components of the geophysical system by adding an energy balance model for the averaged atmospheric temperature as dynamic boundary condition to a diagnostic ocean model having an additional spatial dimension. In this work, we give deeper insight than previous papers in the literature, mainly with respect to the 1990 pioneering model by Watts and Morantine. We are taking into consideration the latent heat for the two phase ocean as well as a possible delayed term. Non-uniqueness for the initial boundary value problem, uniqueness under a non-degeneracy condition and the existence of multiple stationary solutions are proved here. These multiplicity results suggest that an S-shaped bifurcation diagram should be expected to occur in this class of models generalizing previous energy balance models. The numerical method applied to the model is based on a finite volume scheme with nonlinear weighted essentially non-oscillatory reconstruction and Runge-Kutta total variation diminishing for time integration.

  12. Multiple solutions and numerical analysis to the dynamic and stationary models coupling a delayed energy balance model involving latent heat and discontinuous albedo with a deep ocean

    Science.gov (United States)

    Díaz, J. I.; Hidalgo, A.; Tello, L.

    2014-01-01

    We study a climatologically important interaction of two of the main components of the geophysical system by adding an energy balance model for the averaged atmospheric temperature as dynamic boundary condition to a diagnostic ocean model having an additional spatial dimension. In this work, we give deeper insight than previous papers in the literature, mainly with respect to the 1990 pioneering model by Watts and Morantine. We are taking into consideration the latent heat for the two phase ocean as well as a possible delayed term. Non-uniqueness for the initial boundary value problem, uniqueness under a non-degeneracy condition and the existence of multiple stationary solutions are proved here. These multiplicity results suggest that an S-shaped bifurcation diagram should be expected to occur in this class of models generalizing previous energy balance models. The numerical method applied to the model is based on a finite volume scheme with nonlinear weighted essentially non-oscillatory reconstruction and Runge–Kutta total variation diminishing for time integration. PMID:25294969

  13. Do not forget the professional--the value of the FIRST model for guiding the structural involvement of patients in rheumatology research.

    Science.gov (United States)

    de Wit, Maarten P T; Elberse, Janneke E; Broerse, Jacqueline E W; Abma, Tineke A

    2015-08-01

    The FIRST model describes five practical components that enable equal collaboration between patients and professionals in clinical rheumatology research: Facilitate, identify, respect, support and training. To assess the value of this model as a framework for setting up and guiding the structural involvement of people with arthritis in health research. The FIRST model was used as a framework during the guidance of a network of patient research partners and clinical rheumatology departments in the Netherlands. A 'monitoring and evaluation' approach was used to study the network over a period of 2 years. Data were collected using mixed methods and subjected to a directed content analysis. The FIRST components structured the data analysis. During monitoring meetings, refined and additional descriptors for each component were formulated and added if new items were found. The FIRST model helps to guide and foster structural partnerships between patients and professionals in health research projects. However, it should be broadened to emphasize the pivotal role of the principal investigator regarding the facilitation and support of patient research partners, to recognize the requirements of professionals for training and coaching and to capture the dynamics of collaboration, mutual learning processes and continuous reflection. FIRST is a good model to implement sustainable relationships between patients and researchers. It will benefit from further refinement by acknowledging the dynamics of collaboration and including the concept of reflection and relational empowerment. The reciprocal character of the five components, including training and support of researchers, should be incorporated. © 2013 John Wiley & Sons Ltd.

  14. Determination of the Support Level of Local Organizations in a Model Forest Initiative: Do Local Stakeholders Have Willingness to Be Involved in the Model Forest Development?

    Directory of Open Access Journals (Sweden)

    Ahmet Tolunay

    2014-10-01

    Full Text Available Voluntary cooperation and the support of stakeholders carry a major importance in the development of Model Forests. The identification of the support level of local organizations as stakeholders in the Bucak Model Forest initiative, located in the Mediterranean region of Turkey, constitutes the theme of this study. Within this scope, the views of the stakeholders comprising local government units (LGUs, non-governmental organizations (NGOs, village councils (VCs, professional organizations (POs and forest products enterprises (FPEs located in the district of Bucak were collected by utilizing a survey technique. The data were analysed by using non-parametric statistical analyses due to the absence of a normal distribution. The results show that the information provided about the Model Forest concept to the stakeholders located in the district on the Bucak Model Forest initiative was identified as a factor impacting the support level. Moreover, it was also observed that the stakeholders were more willing to provide advisory support rather than financial support. NGOs and VCs were identified as stakeholders who could not provide financial support due to their restricted budgets. We discuss the benefits for a Model Forest initiative of establishing international cooperation to strengthen the local and regional sustainable development process.

  15. In silico Comparative Modeling of PapA1 and PapA2 Proteins Involved in Mycobacterium Tuberculosis Sulfolipid-1 Biosynthesis Pathway

    Directory of Open Access Journals (Sweden)

    Rana Adnan Tahir

    2012-09-01

    Full Text Available Tuberculosis is one of the most serious health problems, as globally; around 2 billion or one third of the world's total population has been infected with Mycobacterium tuberculosis. Mycobacterium tuberculosis is a unique among bacterial pathogens in that it displays a wide array of complex lipids and lipoglycans on its cell surface. One such glycolipid, sulfolipid-1 (SL-1, is the most sulfatide, consists of a trehalose core, four fatty acyl groups, and a sulfate ester. Several proteins involved in SL-1 biosynthesis have been identified, the enzymes that acylate the T2S core to form SL1278 and SL-1, and the biosynthetic order of these acylation reactions, are unknown. Here we studied the in silico identification of PapA2 and PapA1, proteins responsible for the sequential acylation of T2S to form SL1278 and are essential for SL-1 biosynthesis, by applying different bioinformatics tools. Benchmark, of 3 different homology modeling programs Modeller, Swiss-Model (Deep View, and ESyPred3D, has been performed used to transform the alignment to a 3D model. The 3D structures of targeted proteins were evaluated by evaluation tools, ANOLEA and Verify3D. It is concluded that in SL-1 biosynthesis pathway, PapA1 and PapA2 proteins could be used as drug target, drug lead design and to find out the other proteins involved in this pathway that not yet have been identified and may be used to the cure of tuberculosis infection.

  16. Acetylome analysis reveals the involvement of lysine acetylation in photosynthesis and carbon metabolism in the model cyanobacterium Synechocystis sp. PCC 6803.

    Science.gov (United States)

    Mo, Ran; Yang, Mingkun; Chen, Zhuo; Cheng, Zhongyi; Yi, Xingling; Li, Chongyang; He, Chenliu; Xiong, Qian; Chen, Hui; Wang, Qiang; Ge, Feng

    2015-02-06

    Cyanobacteria are the oldest known life form inhabiting Earth and the only prokaryotes capable of performing oxygenic photosynthesis. Synechocystis sp. PCC 6803 (Synechocystis) is a model cyanobacterium used extensively in research on photosynthesis and environmental adaptation. Posttranslational protein modification by lysine acetylation plays a critical regulatory role in both eukaryotes and prokaryotes; however, its extent and function in cyanobacteria remain unexplored. Herein, we performed a global acetylome analysis on Synechocystis through peptide prefractionation, antibody enrichment, and high accuracy LC-MS/MS analysis; identified 776 acetylation sites on 513 acetylated proteins; and functionally categorized them into an interaction map showing their involvement in various biological processes. Consistent with previous reports, a large fraction of the acetylation sites are present on proteins involved in cellular metabolism. Interestingly, for the first time, many proteins involved in photosynthesis, including the subunits of phycocyanin (CpcA, CpcB, CpcC, and CpcG) and allophycocyanin (ApcA, ApcB, ApcD, ApcE, and ApcF), were found to be lysine acetylated, suggesting that lysine acetylation may play regulatory roles in the photosynthesis process. Six identified acetylated proteins associated with photosynthesis and carbon metabolism were further validated by immunoprecipitation and Western blotting. Our data provide the first global survey of lysine acetylation in cyanobacteria and reveal previously unappreciated roles of lysine acetylation in the regulation of photosynthesis. The provided data set may serve as an important resource for the functional analysis of lysine acetylation in cyanobacteria and facilitate the elucidation of the entire metabolic networks and photosynthesis process in this model cyanobacterium.

  17. 生活污水典型有机污染物与ASMs模型水质特性参数相关性研究%Relationship Between Typical Organic Matters in Domestic Wastewater and Water Characteristic Parameters in Activated Sludge Models

    Institute of Scientific and Technical Information of China (English)

    黄满红; 李咏梅; 顾国维

    2009-01-01

    研究了生活污水中典型有机污染物糖类、蛋白质、油脂以及直链烷基苯磺酸钠(LAS)对生活污水中COD的贡献率,采用硝酸盐利用速率法(NUR)测定了活性污泥数学模型(ASMs)中的有机水质特性参数,分析了单一糖类、蛋白质、油脂、LAS对有机水质特性参数的影响,并给出了生活污水中这4种有机污染物与ASMs有机水质特性参数SS、XS、SI、XI的相关关系.结果表明,反硝化条件下异养菌产率系数为0.683;蛋白质、糖类、油脂和LAS分别占COD的24%~35%、 17%~35%、 5.78%~10.56%和 3.77%~7.23%,是污水中COD的主要化学组成成分;该污水中的快速生物降解物质占总COD的22%~29%,慢速可生物降解物质占29%~38%;生活污水中糖类、蛋白质、油脂、LAS这4种典型有机物的浓度与ASMs的水质特性参数SS、XS、SI、XI的相关性较好,相关系数>0.9.%The contribution of typical organic matters such as proteins,sugars,lipids and linear alkylbenzene sulfonate (LAS) to COD of the domestic wastewater was investigated.Nitrate utilization rate was used to determine wastewater characteristic parameters.Relationship between these typical organic matters and wastewater characteristic parameters (SS,XS,SI,XI) in activated sludge models were investigated.The results showed that YH of activated sludge under denitrifying conditions was 0.683. Proteins,sugars,lipids and LAS accounted for 24%-35%,17%-35%,5.78%-10.56% and 3.77%-7.23% of the total COD,respectively.It indicated that these four pollutants were the main COD source in the domestic wastewater.SS and XI were in the ranges of 22%-29% and 29%-38% of the total COD,respectively.Concentrations of the four typical target organic matters (proteins,sugars,lipids and LAS) correlated well with the wastewater characteristic parameters (SS,XS,SI,XI) of activated sludge models (ASMs) with the correlative coefficients above 0.9.

  18. Vertebral osteomyelitis without disc involvement

    Energy Technology Data Exchange (ETDEWEB)

    Kamani, I.; Syed, I.; Saifuddin, A. E-mail: asaifuddin@aol.com; Green, R.; MacSweeney, F

    2004-10-01

    Vertebral osteomyelitis is most commonly due to pyogenic or granulomatous infection and typically results in the combined involvement of the intervertebral disc and adjacent vertebral bodies. Non-infective causes include the related conditions of chronic recurrent multifocal osteomyelitis (CRMO) and SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome. Occasionally, these conditions may present purely within the vertebral body, resulting in various combinations of vertebral marrow oedema and sclerosis, destructive lesions of the vertebral body and pathological vertebral collapse, thus mimicking neoplastic disease. This review illustrates the imaging features of vertebral osteomyelitis without disc involvement, with emphasis on magnetic resonance imaging (MRI) findings.

  19. Vascular smooth muscle G(q) signaling is involved in high blood pressure in both induced renal and genetic vascular smooth muscle-derived models of hypertension.

    Science.gov (United States)

    Harris, David M; Cohn, Heather I; Pesant, Stéphanie; Zhou, Rui-Hai; Eckhart, Andrea D

    2007-11-01

    More than 30% of the US population has high blood pressure (BP), and less than a third of people treated for hypertension have it controlled. In addition, the etiology of most high BP is not known. Having a better understanding of the mechanisms underlying hypertension could potentially increase the effectiveness of treatment. Because G(q) signaling mediates vasoconstriction and vascular function can cause BP abnormalities, we were interested in determining the role of vascular smooth muscle (VSM) G(q) signaling in two divergent models of hypertension: a renovascular model of hypertension through renal artery stenosis and a genetic model of hypertension using mice with VSM-derived high BP. Inhibition of VSM G(q) signaling attenuated BP increases induced by renal artery stenosis to a similar extent as losartan, an ANG II receptor blocker and current antihypertensive therapy. Inhibition of G(q) signaling also attenuated high BP in our genetic VSM-derived hypertensive model. In contrast, BP remained elevated 25% following treatment with losartan, and prazosin, an alpha(1)-adrenergic receptor antagonist, only decreased BP by 35%. Inhibition of G(q) signaling attenuated VSM reactivity to ANG II and resulted in a 2.4-fold rightward shift in EC(50). We also determined that inhibition of G(q) signaling was able to reverse VSM hypertrophy in the genetic VSM-derived hypertensive model. These results suggest that G(q) signaling is an important signaling pathway in two divergent models of hypertension and, perhaps, optimization of antihypertensive therapy could occur with the identification of particular G(q)-coupled receptors involved.

  20. N-methyl-D-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium chloride-pilocarpine chronic rat epilepsy model.

    Science.gov (United States)

    Peng, Wei-Feng; Ding, Jing; Li, Xin; Fan, Fan; Zhang, Qian-Qian; Wang, Xin

    2016-01-01

    Depression is a common comorbidity in patients with epilepsy with unclear mechanisms. This study is to explore the role of glutamate N-methyl-D-aspartate (NMDA) receptor NR1, NR2A and NR2B subunits in epilepsy-associated depression. Lithium chloride (Licl)-pilocarpine chronic rat epilepsy model was established and rats were divided into epilepsy with depression (EWD) and epilepsy without depression (EWND) subgroups based on forced swim test. Expression of NMDA receptor NR1, NR2A and NR2B subunits was measured by western blot and immunofluorescence methods. The immobility time (IMT) was significantly greater in Licl-pilocarpine model group than in Control group, which was also greater in EWD group than in EWND group. No differences of spontaneous recurrent seizure (SRS) counts over two weeks and latency were found between EWD and EWND groups. The number of NeuN positive cells was significantly less in Licl-pilocarpine model group than in Control group, but had no difference between EWD and EWND groups. The ratios of phosphorylated NR1 (p-NR1)/NR1 and p-NR2B/NR2B were significantly greater in the hippocampus in EWD group than in EWND group. Moreover, the expression of p-NR1 and p-NR2B in the CA1 subfield of hippocampus were both greater in Licl-pilocarpine model group than Control group. Selective blockage of NR2B subunit with ifenprodil could alleviate depression-like behaviours of Licl-pilocarpine rat epilepsy model. In conclusion, glutamate NMDA receptor NR2B subunit was involved in promoting depression-like behaviours in the Licl-pilocarpine chronic rat epilepsy model and might be a target for treating epilepsy-associated depression.

  1. Longitudinal changes in cortical thickness in autism and typical development

    Science.gov (United States)

    Prigge, Molly B. D.; Nielsen, Jared A.; Froehlich, Alyson L.; Abildskov, Tracy J.; Anderson, Jeffrey S.; Fletcher, P. Thomas; Zygmunt, Kristen M.; Travers, Brittany G.; Lange, Nicholas; Alexander, Andrew L.; Bigler, Erin D.; Lainhart, Janet E.

    2014-01-01

    The natural history of brain growth in autism spectrum disorders remains unclear. Cross-sectional studies have identified regional abnormalities in brain volume and cortical thickness in autism, although substantial discrepancies have been reported. Preliminary longitudinal studies using two time points and small samples have identified specific regional differences in cortical thickness in the disorder. To clarify age-related trajectories of cortical development, we examined longitudinal changes in cortical thickness within a large mixed cross-sectional and longitudinal sample of autistic subjects and age- and gender-matched typically developing controls. Three hundred and forty-five magnetic resonance imaging scans were examined from 97 males with autism (mean age = 16.8 years; range 3–36 years) and 60 males with typical development (mean age = 18 years; range 4–39 years), with an average interscan interval of 2.6 years. FreeSurfer image analysis software was used to parcellate the cortex into 34 regions of interest per hemisphere and to calculate mean cortical thickness for each region. Longitudinal linear mixed effects models were used to further characterize these findings and identify regions with between-group differences in longitudinal age-related trajectories. Using mean age at time of first scan as a reference (15 years), differences were observed in bilateral inferior frontal gyrus, pars opercularis and pars triangularis, right caudal middle frontal and left rostral middle frontal regions, and left frontal pole. However, group differences in cortical thickness varied by developmental stage, and were influenced by IQ. Differences in age-related trajectories emerged in bilateral parietal and occipital regions (postcentral gyrus, cuneus, lingual gyrus, pericalcarine cortex), left frontal regions (pars opercularis, rostral middle frontal and frontal pole), left supramarginal gyrus, and right transverse temporal gyrus, superior parietal lobule, and

  2. Integrated SNG Production in a Typical Nordic Sawmill

    Directory of Open Access Journals (Sweden)

    Sennai Mesfun

    2016-04-01

    Full Text Available Advanced biomass-based motor fuels and chemicals are becoming increasingly important to replace fossil energy sources within the coming decades. It is likely that the new biorefineries will evolve mainly from existing forest industry sites, as they already have the required biomass handling infrastructure in place. The main objective of this work is to assess the potential for increasing the profit margin from sawmill byproducts by integrating innovative downstream processes. The focus is on the techno-economic evaluation of an integrated site for biomass-based synthetic natural gas (bio-SNG production. The option of using the syngas in a biomass-integrated gasification combined cycle (b-IGCC for the production of electricity (instead of SNG is also considered for comparison. The process flowsheets that are used to analyze the energy and material balances are modelled in MATLAB and Simulink. A mathematical process integration model of a typical Nordic sawmill is used to analyze the effects on the energy flows in the overall site, as well as to evaluate the site economics. Different plant sizes have been considered in order to assess the economy-of-scale effect. The technical data required as input are collected from the literature and, in some cases, from experiments. The investment cost is evaluated on the basis of conducted studies, third party supplier budget quotations and in-house database information. This paper presents complete material and energy balances of the considered processes and the resulting process economics. Results show that in order for the integrated SNG production to be favored, depending on the sawmill size, a biofuel subsidy in the order of 28–52 €/MWh SNG is required.

  3. Consciousness and the structuring property of typical data

    Science.gov (United States)

    Mason, Jonathan W. D.

    2013-01-01

    The theoretical base for consciousness, in particular an explanation of how consciousness is defined by the brain, has long been sought by science. We propose a partial theory of consciousness as relations defined by typical data. The theory is based on the idea that a brain state on its own is almost meaningless but in the context of the typical brain states, defined by the brain's structure, a particular brain state is highly structured by relations. The proposed theory can be applied and tested both theoretically and experimentally. Precisely how typical data determines relations is fully established using discrete mathematics.

  4. Review of Real-Time Simulator and the Steps Involved for Implementation of a Model from MATLAB/SIMULINK to Real-Time

    Science.gov (United States)

    Mikkili, Suresh; Panda, Anup Kumar; Prattipati, Jayanthi

    2014-07-01

    Nowadays the researchers want to develop their model in real-time environment. Simulation tools have been widely used for the design and improvement of electrical systems since the mid twentieth century. The evolution of simulation tools has progressed in step with the evolution of computing technologies. In recent years, computing technologies have improved dramatically in performance and become widely available at a steadily decreasing cost. Consequently, simulation tools have also seen dramatic performance gains and steady cost decreases. Researchers and engineers now have the access to affordable, high performance simulation tools that were previously too cost prohibitive, except for the largest manufacturers. This work has introduced a specific class of digital simulator known as a real-time simulator by answering the questions "what is real-time simulation", "why is it needed" and "how it works". The latest trend in real-time simulation consists of exporting simulation models to FPGA. In this article, the Steps involved for implementation of a model from MATLAB to REAL-TIME are provided in detail.

  5. Alteration in Marrow Stromal Microenvironment and Apoptosis Mechanisms Involved in Aplastic Anemia: An Animal Model to Study the Possible Disease Pathology

    Directory of Open Access Journals (Sweden)

    Sumanta Chatterjee

    2010-01-01

    Full Text Available Aplastic anemia (AA is a heterogeneous disorder of bone marrow failure syndrome. Suggested mechanisms include a primary stem cell deficiency or defect, a secondary stem cell defect due to abnormal regulation between cell death and differentiation, or a deficient microenvironment. In this study, we have tried to investigate the alterations in hematopoietic microenvironment and underlying mechanisms involved in such alterations in an animal model of drug induced AA. We presented the results of studying long term marrow culture, marrow ultra-structure, marrow adherent and hematopoietic progenitor cell colony formation, flowcytometric analysis of marrow stem and stromal progenitor populations and apoptosis mechanism involved in aplastic anemia. The AA marrow showed impairment in cellular proliferation and maturation and failed to generate a functional stromal microenvironment even after 19 days of culture. Ultra-structural analysis showed a degenerated and deformed marrow cellular association in AA. Colony forming units (CFUs were also severely reduced in AA. Significantly decreased marrow stem and stromal progenitor population with subsequently increased expression levels of both the extracellular and intracellular apoptosis inducer markers in the AA marrow cells essentially pointed towards the defective hematopoiesis; moreover, a deficient and apoptotic microenvironment and the microenvironmental components might have played the important role in the possible pathogenesis of AA.

  6. Heterogeneity in the Relationship of Substance Use to Risky Sexual Behavior Among Justice-Involved Youth: A Regression Mixture Modeling Approach.

    Science.gov (United States)

    Schmiege, Sarah J; Bryan, Angela D

    2016-04-01

    Justice-involved adolescents engage in high levels of risky sexual behavior and substance use, and understanding potential relationships among these constructs is important for effective HIV/STI prevention. A regression mixture modeling approach was used to determine whether subgroups could be identified based on the regression of two indicators of sexual risk (condom use and frequency of intercourse) on three measures of substance use (alcohol, marijuana and hard drugs). Three classes were observed among n = 596 adolescents on probation: none of the substances predicted outcomes for approximately 18 % of the sample; alcohol and marijuana use were predictive for approximately 59 % of the sample, and marijuana use and hard drug use were predictive in approximately 23 % of the sample. Demographic, individual difference, and additional sexual and substance use risk variables were examined in relation to class membership. Findings are discussed in terms of understanding profiles of risk behavior among at-risk youth.

  7. Clustering consumers based on trust, confidence and giving behaviour: data-driven model building for charitable involvement in the Australian not-for-profit sector.

    Directory of Open Access Journals (Sweden)

    Natalie Jane de Vries

    Full Text Available Organisations in the Not-for-Profit and charity sector face increasing competition to win time, money and efforts from a common donor base. Consequently, these organisations need to be more proactive than ever. The increased level of communications between individuals and organisations today, heightens the need for investigating the drivers of charitable giving and understanding the various consumer groups, or donor segments, within a population. It is contended that `trust' is the cornerstone of the not-for-profit sector's survival, making it an inevitable topic for research in this context. It has become imperative for charities and not-for-profit organisations to adopt for-profit's research, marketing and targeting strategies. This study provides the not-for-profit sector with an easily-interpretable segmentation method based on a novel unsupervised clustering technique (MST-kNN followed by a feature saliency method (the CM1 score. A sample of 1,562 respondents from a survey conducted by the Australian Charities and Not-for-profits Commission is analysed to reveal donor segments. Each cluster's most salient features are identified using the CM1 score. Furthermore, symbolic regression modelling is employed to find cluster-specific models to predict `low' or `high' involvement in clusters. The MST-kNN method found seven clusters. Based on their salient features they were labelled as: the `non-institutionalist charities supporters', the `resource allocation critics', the `information-seeking financial sceptics', the `non-questioning charity supporters', the `non-trusting sceptics', the `charity management believers' and the `institutionalist charity believers'. Each cluster exhibits their own characteristics as well as different drivers of `involvement'. The method in this study provides the not-for-profit sector with a guideline for clustering, segmenting, understanding and potentially targeting their donor base better. If charities and not

  8. A Quantitative Risk Assessment Model Involving Frequency and Threat Degree under Line-of-Business Services for Infrastructure of Emerging Sensor Networks.

    Science.gov (United States)

    Jing, Xu; Hu, Hanwen; Yang, Huijun; Au, Man Ho; Li, Shuqin; Xiong, Naixue; Imran, Muhammad; Vasilakos, Athanasios V

    2017-03-21

    The prospect of Line-of-Business Services (LoBSs) for infrastructure of Emerging Sensor Networks (ESNs) is exciting. Access control remains a top challenge in this scenario as the service provider's server contains a lot of valuable resources. LoBSs' users are very diverse as they may come from a wide range of locations with vastly different characteristics. Cost of joining could be low and in many cases, intruders are eligible users conducting malicious actions. As a result, user access should be adjusted dynamically. Assessing LoBSs' risk dynamically based on both frequency and threat degree of malicious operations is therefore necessary. In this paper, we proposed a Quantitative Risk Assessment Model (QRAM) involving frequency and threat degree based on value at risk. To quantify the threat degree as an elementary intrusion effort, we amend the influence coefficient of risk indexes in the network security situation assessment model. To quantify threat frequency as intrusion trace effort, we make use of multiple behavior information fusion. Under the influence of intrusion trace, we adapt the historical simulation method of value at risk to dynamically access LoBSs' risk. Simulation based on existing data is used to select appropriate parameters for QRAM. Our simulation results show that the duration influence on elementary intrusion effort is reasonable when the normalized parameter is 1000. Likewise, the time window of intrusion trace and the weight between objective risk and subjective risk can be set to 10 s and 0.5, respectively. While our focus is to develop QRAM for assessing the risk of LoBSs for infrastructure of ESNs dynamically involving frequency and threat degree, we believe it is also appropriate for other scenarios in cloud computing.

  9. A Quantitative Risk Assessment Model Involving Frequency and Threat Degree under Line-of-Business Services for Infrastructure of Emerging Sensor Networks

    Science.gov (United States)

    Jing, Xu; Hu, Hanwen; Yang, Huijun; Au, Man Ho; Li, Shuqin; Xiong, Naixue; Imran, Muhammad; Vasilakos, Athanasios V.

    2017-01-01

    The prospect of Line-of-Business Services (LoBSs) for infrastructure of Emerging Sensor Networks (ESNs) is exciting. Access control remains a top challenge in this scenario as the service provider’s server contains a lot of valuable resources. LoBSs’ users are very diverse as they may come from a wide range of locations with vastly different characteristics. Cost of joining could be low and in many cases, intruders are eligible users conducting malicious actions. As a result, user access should be adjusted dynamically. Assessing LoBSs’ risk dynamically based on both frequency and threat degree of malicious operations is therefore necessary. In this paper, we proposed a Quantitative Risk Assessment Model (QRAM) involving frequency and threat degree based on value at risk. To quantify the threat degree as an elementary intrusion effort, we amend the influence coefficient of risk indexes in the network security situation assessment model. To quantify threat frequency as intrusion trace effort, we make use of multiple behavior information fusion. Under the influence of intrusion trace, we adapt the historical simulation method of value at risk to dynamically access LoBSs’ risk. Simulation based on existing data is used to select appropriate parameters for QRAM. Our simulation results show that the duration influence on elementary intrusion effort is reasonable when the normalized parameter is 1000. Likewise, the time window of intrusion trace and the weight between objective risk and subjective risk can be set to 10 s and 0.5, respectively. While our focus is to develop QRAM for assessing the risk of LoBSs for infrastructure of ESNs dynamically involving frequency and threat degree, we believe it is also appropriate for other scenarios in cloud computing. PMID:28335569

  10. Clustering Consumers Based on Trust, Confidence and Giving Behaviour: Data-Driven Model Building for Charitable Involvement in the Australian Not-For-Profit Sector

    Science.gov (United States)

    de Vries, Natalie Jane; Reis, Rodrigo; Moscato, Pablo

    2015-01-01

    Organisations in the Not-for-Profit and charity sector face increasing competition to win time, money and efforts from a common donor base. Consequently, these organisations need to be more proactive than ever. The increased level of communications between individuals and organisations today, heightens the need for investigating the drivers of charitable giving and understanding the various consumer groups, or donor segments, within a population. It is contended that `trust' is the cornerstone of the not-for-profit sector's survival, making it an inevitable topic for research in this context. It has become imperative for charities and not-for-profit organisations to adopt for-profit's research, marketing and targeting strategies. This study provides the not-for-profit sector with an easily-interpretable segmentation method based on a novel unsupervised clustering technique (MST-kNN) followed by a feature saliency method (the CM1 score). A sample of 1,562 respondents from a survey conducted by the Australian Charities and Not-for-profits Commission is analysed to reveal donor segments. Each cluster's most salient features are identified using the CM1 score. Furthermore, symbolic regression modelling is employed to find cluster-specific models to predict `low' or `high' involvement in clusters. The MST-kNN method found seven clusters. Based on their salient features they were labelled as: the `non-institutionalist charities supporters', the `resource allocation critics', the `information-seeking financial sceptics', the `non-questioning charity supporters', the `non-trusting sceptics', the `charity management believers' and the `institutionalist charity believers'. Each cluster exhibits their own characteristics as well as different drivers of `involvement'. The method in this study provides the not-for-profit sector with a guideline for clustering, segmenting, understanding and potentially targeting their donor base better. If charities and not

  11. Clustering consumers based on trust, confidence and giving behaviour: data-driven model building for charitable involvement in the Australian not-for-profit sector.

    Science.gov (United States)

    de Vries, Natalie Jane; Reis, Rodrigo; Moscato, Pablo

    2015-01-01

    Organisations in the Not-for-Profit and charity sector face increasing competition to win time, money and efforts from a common donor base. Consequently, these organisations need to be more proactive than ever. The increased level of communications between individuals and organisations today, heightens the need for investigating the drivers of charitable giving and understanding the various consumer groups, or donor segments, within a population. It is contended that `trust' is the cornerstone of the not-for-profit sector's survival, making it an inevitable topic for research in this context. It has become imperative for charities and not-for-profit organisations to adopt for-profit's research, marketing and targeting strategies. This study provides the not-for-profit sector with an easily-interpretable segmentation method based on a novel unsupervised clustering technique (MST-kNN) followed by a feature saliency method (the CM1 score). A sample of 1,562 respondents from a survey conducted by the Australian Charities and Not-for-profits Commission is analysed to reveal donor segments. Each cluster's most salient features are identified using the CM1 score. Furthermore, symbolic regression modelling is employed to find cluster-specific models to predict `low' or `high' involvement in clusters. The MST-kNN method found seven clusters. Based on their salient features they were labelled as: the `non-institutionalist charities supporters', the `resource allocation critics', the `information-seeking financial sceptics', the `non-questioning charity supporters', the `non-trusting sceptics', the `charity management believers' and the `institutionalist charity believers'. Each cluster exhibits their own characteristics as well as different drivers of `involvement'. The method in this study provides the not-for-profit sector with a guideline for clustering, segmenting, understanding and potentially targeting their donor base better. If charities and not

  12. Evaluating propensity score balance measures in typical pharmacoepidemiological settings

    NARCIS (Netherlands)

    Ali, Mohammed S.; Groenwold, Rolf H. H.; Pestman, Wiebe R.; Belitser, S.; Hoes, Arno W.; Roes, Kit C. B.; De Boer, Anthonius; Klungel, Olaf H.

    2012-01-01

    Background: Several propensity score (PS) balance measures have been compared in simulated data with normally distributed covariates. Comparisons in data with binary or mixed covariate distributions and rare outcomes, typical of pharmacoepidemiologic data sets, are scarce. Objectives: To compare bal

  13. Gearbox Typical Failure Modes, Detection, and Mitigation Methods (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Sheng, S.

    2014-01-01

    This presentation was given at the AWEA Operations & Maintenance and Safety Seminar and focused on what the typical gearbox failure modes are, how to detect them using detection techniques, and strategies that help mitigate these failures.

  14. Three Typical Dermatological Cases Treated by Dr. Li Yueping

    Institute of Scientific and Technical Information of China (English)

    Xie Shaoqiong

    2005-01-01

    @@ Dr. Li Yueping has been engaged in dermatological clinic for more than 40 years, accumulating rich experience in treating dermatological diseases. The following is three typical cases she gave successful treatment.

  15. Tomographic maps of typical radio signals and their superpositions

    NARCIS (Netherlands)

    Man'ko, [No Value; Usoltsev, AS

    2002-01-01

    Following the procedure of noncommutative tomography of analytic signals, some typical radio signals are analyzed. Tomograms of rectangular pulses, delta-pulses, and Gaussian signals are presented. Properties of the noncommutative tomography method are discussed.

  16. Endoplasmic Reticulum Is Involved in Myocardial Injury in a Miniature Swine Model of Coronary Artery Stenosis Exposed to Acceleration-Associated Stress

    Science.gov (United States)

    Zhang, Haitao; Chai, Meng; Liu, Chaozhong; Sun, Jinjin; Huang, Congchun; Yu, Xinya; Tian, Yi; Luo, Huilan

    2015-01-01

    This study aimed to investigate the effects of myocardial injury in a minimally-invasive miniature swine model with different levels of coronary artery stenosis (CAS) and exposed to maximal tolerated +Gz. Proximal left anterior descending branch was ligated in 20 swine. Five swine underwent a sham operation. A trapezoid acceleration curve was used for +Gz stress. Pathological changes of myocardial tissue were detected by H&E staining. Apoptotic cardiomyocytes were detected by TUNEL. GRP78 and CHOP were investigated by immunohistochemistry and western blot. CAS models were successful in 18 animals.Compared with the sham-operated group (+8.00±0.71 Gz), the maximal tolerated +Gz values of the moderate stenosis (+6.00±0.89 Gz, Pstenosis groups (+5.20±0.84 Gz, Pstenosis group (60.50±9.35%, Pstenosis groups (0.35±0.04), while expression was high in the moderate (0.72±0.04, Pstenosis groups (0.65±0.07, Pstenosis groups. These results indicated that Under maximum exposure to +Gz stress, different levels of CAS led to different levels of myocardial injury. Endoplasmic reticulum response is involved in the apoptosis of cardiomyocytes after +Gz stress. PMID:26167928

  17. Objective color harmony assessment for visible and infrared color fusion images of typical scenes

    Science.gov (United States)

    Gao, Shaoshu; Jin, Weiqi; Wang, Lingxue

    2012-11-01

    For visible and infrared color fusion images of three typical scenes, color harmony computational models are proposed to evaluate the color quality of fusion images without reference images. The models are established based on the color-combination harmony model and focus on the influence of the color characteristics of typical scenes and the color region sizes in the fusion image. For the influence of the color characteristics of typical scenes, color harmony adjusting factors for natural scene images (green plants, sea, and sky) are defined by measuring the similarity between image colors and corresponding memory colors, and that for town and building images are presented based on the optimum colorfulness range suited for a human. Simultaneously, considering the influence of color region sizes, the weight coefficients are established using areas of the color regions to optimize the color harmony model. Experimental results show that the proposed harmony models are consistent with human perception and that they are suitable to evaluate the color harmony for color fusion images of typical scenes.

  18. [Nail involvement in leprosy].

    Science.gov (United States)

    Belinchón Romero, I; Ramos Rincón, J M; Reyes Rabell, F

    2012-05-01

    Leprosy, a disease caused by Mycobacterium leprae, primarily affects the skin and nerves, but the nails are also involved in as many as 3 out of 4 patients .The factors that trigger nail changes in leprosy are numerous and include repeated trauma, neuropathy, vascular impairment, infections, lepra reactions, and the drugs used to manage the disease. The changes most often reported include subungual hematomas, onycholysis, onychauxis, onychogryphosis, pterygium unguis, and onychoheterotopia, most of which can be attributed to nerve damage and trauma. Furthermore, the acro-osteolysis that occurs in the advanced stages of the disease may present with brachyonychia, racquet nails, or even anonychia. Infections of the nail bed leading to paronychia and onychomycosis should also be taken into account in leprosy. Other typical changes include longitudinal striae, pitting, macrolunula, Terry nails, leukonychia, hapalonychia, and Beau lines. In this review, we describe the principal nail changes associated with leprosy. These changes, which are highly varied and diverse in origin, are in fact a reflection of the significant morbidity caused by M. leprae infection.

  19. The proinflammatory RAGE/NF-κB pathway is involved in neuronal damage and reactive gliosis in a model of sleep apnea by intermittent hypoxia.

    Science.gov (United States)

    Angelo, Maria Florencia; Aguirre, Alejandra; Avilés Reyes, Rolando X; Villarreal, Alejandro; Lukin, Jerónimo; Melendez, Matías; Vanasco, Virginia; Barker, Phil; Alvarez, Silvia; Epstein, Alberto; Jerusalinsky, Diana; Ramos, Alberto Javier

    2014-01-01

    Sleep apnea (SA) causes long-lasting changes in neuronal circuitry, which persist even in patients successfully treated for the acute effects of the disease. Evidence obtained from the intermittent hypoxia (IH) experimental model of SA has shown neuronal death, impairment in learning and memory and reactive gliosis that may account for cognitive and structural alterations observed in human patients. However, little is known about the mechanism controlling these deleterious effects that may be useful as therapeutic targets in SA. The Receptor for Advanced Glycation End products (RAGE) and its downstream effector Nuclear Factor Kappa B (NF-κB) have been related to neuronal death and astroglial conversion to the pro-inflammatory neurodegenerative phenotype. RAGE expression and its ligand S100B were shown to be increased in experimental models of SA. We here used dissociated mixed hippocampal cell cultures and male Wistar rats exposed to IH cycles and observed that NF-κB is activated in glial cells and neurons after IH. To disclose the relative contribution of the S100B/RAGE/NF-κB pathway to neuronal damage and reactive gliosis after IH we performed sequential loss of function studies using RAGE or S100B neutralizing antibodies, a herpes simplex virus (HSV)-derived amplicon vector that induces the expression of RAGEΔcyto (dominant negative RAGE) and a chemical blocker of NF-κB. Our results show that NF-κB activation peaks 3 days after IH exposure, and that RAGE or NF-κB blockage during this critical period significantly improves neuronal survival and reduces reactive gliosis. Both in vitro and in vivo, S100B blockage altered reactive gliosis but did not have significant effects on neuronal survival. We conclude that both RAGE and downstream NF-κB signaling are centrally involved in the neuronal alterations found in SA models, and that blockage of these pathways is a tempting strategy for preventing neuronal degeneration and reactive gliosis in SA.

  20. Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model.

    Science.gov (United States)

    Vergo, Sandra; Craner, Matthew J; Etzensperger, Ruth; Attfield, Kathrine; Friese, Manuel A; Newcombe, Jia; Esiri, Margaret; Fugger, Lars

    2011-02-01

    Although there is growing evidence for a role of excess intracellular cations, particularly calcium ions, in neuronal and glial cell injury in multiple sclerosis, as well as in non-inflammatory neurological conditions, the molecular mechanisms involved are not fully determined. We previously showed that the acid-sensing ion channel 1 which, when activated under the acidotic tissue conditions found in inflammatory lesions opens to allow influx of sodium and calcium ions, contributes to axonal injury in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. However, the extent and cellular distribution of acid-sensing ion channel 1 expression in neurons and glia in inflammatory lesions is unknown and, crucially, acid-sensing ion channel 1 expression has not been determined in multiple sclerosis lesions. Here we studied acute and chronic experimental autoimmune encephalomyelitis and multiple sclerosis spinal cord and optic nerve tissues to describe in detail the distribution of acid-sensing ion channel 1 and its relationship with neuronal and glial damage. We also tested the effects of amiloride treatment on tissue damage in the mouse models. We found that acid-sensing ion channel 1 was upregulated in axons and oligodendrocytes within lesions from mice with acute experimental autoimmune encephalomyelitis and from patients with active multiple sclerosis. The expression of acid-sensing ion channel 1 was associated with axonal damage as indicated by co-localization with the axonal injury marker beta amyloid precursor protein. Moreover, blocking acid-sensing ion channel 1 with amiloride protected both myelin and neurons from damage in the acute model, and when given either at disease onset or, more clinically relevant, at first relapse, ameliorated disability in mice with chronic-relapsing experimental autoimmune encephalomyelitis. Together these findings suggest that blockade of acid-sensing ion channel 1 has the potential to provide both neuro

  1. Food and Wine Tourism: an Analysis of Italian Typical Products

    Directory of Open Access Journals (Sweden)

    Francesco Maria Olivieri

    2015-06-01

    Full Text Available The aim of this work is to focus the specific role of local food productions in spite of its relationship with tourism sector to valorization and promotion of the territorial cultural heritage. The modern agriculture has been and, in the recent years, several specific features are emerging referring to different territorials areas. Tourist would like to have a complete experience consumption of a destination, specifically to natural and cultural heritage and genuine food. This contribute addresses the topics connected to the relationship between typical productions system and tourism sector to underline the competitive advantages to local development. The typical productions are Designation of Protected Origin (Italian DOP, within wine certifications DOCG and DOC and Typical Geographical Indication (IGP and wine’s IGT. The aim is an analysis of the specialization of these kinds of production at Italian regional scale. The implication of the work has connected with defining a necessary and appropriate value strategies based on marketing principles in order to translate the benefit of typical productions to additional value for the local system. Thus, the final part of the paper describes the potential dynamics with the suitable accommodation typology of agriturismo and the typical production system of Italian Administrative Regions.

  2. The Effects of Sub-Chronic Treatment with Pioglitazone on the Septic Mice Mortality in the Model of Cecal Ligation and Puncture: Involvement of Nitric Oxide Pathway

    Directory of Open Access Journals (Sweden)

    Hamed Shafaroodi

    2015-10-01

    Full Text Available Sepsis is a systemic inflammatory response syndrome caused by an infection and remains as a major challenge in health care. Many studies have reported that pioglitazone may display anti-inflammatory effects. This study was designed to evaluate the effect of subchronic treatment with pioglitazone on high-grade septic mice survival and nitrergic system involvement. Diffused sepsis was induced by cecal ligation and puncture (CLP surgery in male NMRI mice (20-30 g. Pioglitazone (5,10 and 20 mg/kg was administered by gavage daily for 5 days prior to surgery. Nitric oxide involvement was assessed by sub-chronic administration of a non-selective nitric oxide synthase inhibitor, L-NAME and a selective inducible nitric oxide synthase inhibitor, aminoguanidine. TNF-α  and IL-1β plasma levels were measured by ELISA. Pioglitazone (10 and 20 mg/kg significantly improved survival rate in septic mice. The chronic intraperitoneally co-administration of L-NAME (0.5 mg/kg, daily or aminoguanidine (1 mg/kg, daily with a daily dose of pioglitazone, 5 mg/kg, significantly increased the survival rate. This survival improving effect was accompanied by a significant reduction in pro-inflammatory cytokines TNF-α and IL-1β plasma levels. In conclusion, sub-chronic pioglitazone treatment can improve survival in mouse sepsis model by CLP. Inhibition of nitric oxide release, probably through inducible nitric oxide synthase at least in part is responsible for this effect. Suppression of TNF-α and IL-1β could be another mechanism in pioglitazone-induced survival improving effect in septic mice.

  3. The Effects of Sub-Chronic Treatment with Pioglitazone on the Septic Mice Mortality in the Model of Cecal Ligation and Puncture: Involvement of Nitric Oxide Pathway.

    Science.gov (United States)

    Shafaroodi, Hamed; Hassanipour, Mahsa; Mousavi, Zahra; Rahimi, Nastaran; Dehpour, Ahmad Reza

    2015-10-01

    Sepsis is a systemic inflammatory response syndrome caused by an infection and remains as a major challenge in health care. Many studies have reported that pioglitazone may display anti-inflammatory effects. This study was designed to evaluate the effect of subchronic treatment with pioglitazone on high-grade septic mice survival and nitrergic system involvement. Diffused sepsis was induced by cecal ligation and puncture (CLP) surgery in male NMRI mice (20-30 g). Pioglitazone (5,10 and 20 mg/kg) was administered by gavage daily for 5 days prior to surgery. Nitric oxide involvement was assessed by sub-chronic administration of a non-selective nitric oxide synthase inhibitor, L-NAME and a selective inducible nitric oxide synthase inhibitor, aminoguanidine. TNF-α  and IL-1β plasma levels were measured by ELISA. Pioglitazone (10 and 20 mg/kg) significantly improved survival rate in septic mice. The chronic intraperitoneally co-administration of L-NAME (0.5 mg/kg, daily) or aminoguanidine (1 mg/kg, daily) with a daily dose of pioglitazone, 5 mg/kg, significantly increased the survival rate. This survival improving effect was accompanied by a significant reduction in pro-inflammatory cytokines TNF-α and IL-1β plasma levels. In conclusion, sub-chronic pioglitazone treatment can improve survival in mouse sepsis model by CLP. Inhibition of nitric oxide release, probably through inducible nitric oxide synthase at least in part is responsible for this effect. Suppression of TNF-α and IL-1β could be another mechanism in pioglitazone-induced survival improving effect in septic mice.

  4. A new model involving ethylene, nitric oxide and Fe to explain the regulation of Fe-acquisition genes in Strategy I plants.

    Science.gov (United States)

    García, María J; Suárez, Vicente; Romera, Francisco J; Alcántara, Esteban; Pérez-Vicente, Rafael

    2011-05-01

    In previous work it has been shown that both ethylene and NO (nitric oxide) participate in a similar way in the up-regulation of several Fe-acquisition genes of Arabidopsis and other Strategy I plants. This raises the question as to whether NO acts through ethylene or ethylene acts through NO, or whether both act in conjunction. One possibility is that NO could increase ethylene production. Conversely, ethylene could increase NO production. By using Arabidopsis and cucumber plants, we have found that both possibilities occur: NO greatly induces the expression in roots of genes involved in ethylene synthesis: AtSAM1, AtSAM2, AtACS4, AtACS6, AtACO1, AtACO2, AtMTK; CsACS2 and CsACO2; on the other hand, ethylene greatly enhances NO production in the subapical region of the roots. These results suggest that each substance influences the production of the other and that both substances could be necessary for up-regulation of Fe-acquisition genes. This has been further confirmed in experiments with simultaneous application of the NO donor GSNO (S-nitrosoglutathione) and ethylene inhibitors; or with simultaneous application of the ethylene precursor ACC (1-aminocyclopropane-1-carboxylic acid) and an NO scavenger. Both GSNO and ACC enhanced ferric reductase activity in control plants, but not in those plants simultaneously treated with the ethylene inhibitors or the NO scavenger, respectively. To explain all these results and previous ones we have proposed a new model involving ethylene, NO, and Fe in the up-regulation of Fe-acquisition genes of Strategy I plants. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  5. Typical Skin Injuries in Children With Autism Spectrum Disorder.

    Science.gov (United States)

    Slingsby, Brett; Yatchmink, Yvette; Goldberg, Amy

    2017-09-01

    Pediatric skin injuries have primarily been described in typically developing children. Our objectives were to describe the prevalence and pattern of skin injuries of children with autism spectrum disorder (ASD), to describe how this compared with previously demonstrated skin injury locations in typically developing children, and to identify differences in skin injury frequency and locations between autistic children with and without self-injurious behaviors (SIBs). Children with ASD were recruited between September of 2011 and September of 2014. Demographic information was obtained from the caregiver. All skin injuries and their locations were documented. Of the 41 children enrolled, half were reported to have SIBs. The most identified skin injury locations were the legs, knees, and back. Children with autism (1) obtain skin injuries frequently and in similar locations as typically developing children and (2) rarely obtain skin injuries to locations that are considered uncommon for accidental injuries despite reports of SIBs.

  6. Macrostructure in the Narratives of Estonian Children with Typical Development and Language Impairment

    Science.gov (United States)

    Soodla, Piret; Kikas, Eve

    2010-01-01

    Purpose: This study examined the macrostructure in Estonian children's narratives according to the story grammar (SG) model. The study's aims were to determine whether differences exist in narrative macrostructure between Estonian- and English-speaking children, among typically developed (TD) children, and between children with and without…

  7. Spatial Resolution of the ECE for JET Typical Parameters

    Energy Technology Data Exchange (ETDEWEB)

    Tribaldos, V. [Ciemat. Madrid (Spain)

    2000-07-01

    The purpose of this report is to obtain estimations of the spatial resolution of the electron cyclotron emission (ECE) phenomena for the typical plasmas found in JET tokamak. The analysis of the spatial resolution of the ECE is based on the underlying physical process of emission and a working definition is presented and discussed. In making these estimations a typical JET pulse is being analysed taking into account the magnetic configuration, the density and temperature profiles, obtained with the EFIT code and from the LIDAR diagnostic. Ray tracing simulations are performed for a Maxwellian plasma taking into account the antenna pattern. (Author) 5 refs.

  8. Trade-offs among ecosystem services in a typical Karst watershed, SW China.

    Science.gov (United States)

    Tian, Yichao; Wang, Shijie; Bai, Xiaoyong; Luo, Guangjie; Xu, Yan

    2016-10-01

    Nowadays, most research results on ecosystem services in Karst areas are limited to a single function of an ecosystem service. Few scholars conduct a comparative study on the mutual relationships among ecosystem services, let alone reveal the trade-off and synergic relationships in typical Karst watershed. This research aims to understand and quantitatively evaluate the relationships among ecosystem services in a typical Karst watershed, broaden the depth and width of trade-off and synergic relationships in ecosystem services and explore a set of technical processes involved in these relationships. With the Shibantang Karst watershed in China as the research site, we explore the trade-off and synergic relationships of net primary productivity (NPP), water yield, and sediment yield by coupling Soil and Water Assessment Tool (SWAT) and Carnegie-Ames-Stanford Approach (CASA), and simulating and evaluating these three ecosystem services between 2000 and 2010. Results of this study are as follows. (1) The annual average water yield decreased from 528mm in 2000 to 513mm in 2010, decreasing by 2.84%. (2) The annual average sediment yield decreased from 26.15t/ha in 2000 to 23.81t/ha in 2010, with an average annual reduction of 0.23t/ha. (3) The annual average NPP increased from 739.38gCm(-2)a(-1) in 2000 to 746.25gCm(-2)a(-1) in 2010, increasing by 6.87gCm(-2)a(-1) . (4) Water yield and sediment yield are in a synergic relationship. The increase of water yield can accumulate the soil erosion amount. NPP is in a trade-off relationship with water yield and sediment yield. The improvement of NPP is good for decreasing water yield and soil erosion amount and increasing soil conservation amount. This study provides policy makers and planners an approach to develop an integrated model, as well as design mapping and monitoring protocols for land use change and ecosystem service assessments.

  9. A nootropic effect of Moringa oleifera on Ach and ChAT activity in colchicine induced experimental rat model of Alzheimer’s disease: Possible involvement of antioxidants

    Directory of Open Access Journals (Sweden)

    Chandan Roy

    2014-04-01

    Full Text Available Context: The fruit and leaf of Moringa oleifera (MO is an important ingredient of ‘Kusmanda lehyam’ (Ayurvedic medicine, which is widely used, in nervous disorders. Objective: To determine the cognition facilitating effect of MO leaf extract in colchicine induced experimental rat model of AD and to investigate the role of central cholinergic system in the nootropic effect of MO leaf extract with the possible involvement of antioxidant enzymes. Materials and methods: The behavior study, Acetylcholine concentration, cholineacetyl transferase activity, antioxidant level such as, superoxide dismutase (SOD, catalase (CAT, reduced glutathione (GSH and lipid peroxidation (LPO level were studied in different parts of the brain such as frontal cortex (FC and hippocampus (HPC in colchicine induced experimental Alzheimer rat model before and after treatment with MO. Results: MO (250 mg/kg p.o. induced statistically significant reversal of colchicine induced cognitive deficits. MO (250 mg/kg p.o. markedly induced frontal, cortical and hippocampal concentrations of Ach and ChAt activity, the effects being statistically significant on days 7, 14 and 21 respectively. Moreover, MO significantly increased SOD, CAT, GSH activities and significantly decreased LPO level on day 7, 14 and 21 respectively. Discussion and conclusion: The aqueous pulp extract of MO (250 mg/kg body weight containing vit- A, C, E results significant protection in the level of antioxidant status in frontal cortex and hippocampus after a certain period of co administration on colchicine induced oxidative stress without causing any general and metabolic toxicity and possibly thereby induced frontal cortical and hippocampal concentration of Ach and ChAT activity.

  10. Decreased expression of proteins involved in energy metabolism in the hippocampal granular layer of rats submitted to the pilocarpine epilepsy model.

    Science.gov (United States)

    Araujo, Bruno; Torres, Laila; Stein, Mariana; Cabral, Francisco Romero; Herai, Roberto; Okamoto, Oswaldo; Cavalheiro, Esper

    2014-02-21

    Long-term structural and functional changes in the hippocampus have been identified as the primary physiopathological basis for temporal lobe epilepsy. These changes include reactive gliosis and granule cell axonal sprouting within the dentate gyrus. The intimate mechanisms of these changes are beginning to be revealed. Here, we show the possibility of using laser capture microdissection (LCM) to isolate the dentate granular cell layer of Wistar rats submitted to the pilocarpine model of epilepsy. Using two-dimensional gel electrophoresis (2-D PAGE) and mass spectrometry for laser-captured cells, we identified molecular events that could be altered as part of the epileptic pathogenic process. According to our results, eight proteins related to energy metabolism were differentially expressed between both the control and pilocarpine-treated animals. These results provide, for the first time, new molecular insights into the altered protein profile of the epileptogenic dentate gyrus and can contribute to a better understanding of the phenomena involved in the genesis and maintenance of the epileptic state.

  11. Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis.

    Science.gov (United States)

    Nepal, Saroj; Kim, Mi Jin; Hong, Jin Tae; Kim, Sang Hyun; Sohn, Dong-Hwan; Lee, Sung Hee; Song, Kyung; Choi, Dong Young; Lee, Eung Seok; Park, Pil-Hoon

    2015-03-30

    Leptin, a hormone mainly produced from adipose tissue, has been shown to induce proliferation of cancer cells. However, the molecular mechanisms underlying leptin-induced tumor progression have not been clearly elucidated. In the present study, we investigated the role of autophagy in leptin-induced cancer cell proliferation using human hepatoma (HepG2) and breast cancer cells (MCF-7), and tumor growth in a xenograft model. Herein, we showed that leptin treatment caused autophagy induction as assessed by increase in expression of autophagy-related genes, including beclin-1, Atg5 and LC3 II, further induction of autophagosome formation and autophagic flux. Interestingly, inhibition of autophagic process by treatment with inhibitors and LC3B gene silencing blocked leptin-induced increase in cell number and suppression of apoptosis, indicating a crucial role of autophagy in leptin-induced tumor progression. Moreover, gene silencing of p53 or FoxO3A prevented leptin-induced LC3 II protein expression, suggesting an involvement of p53/FoxO3A axis in leptin-induced autophagy activation. Leptin administration also accelerated tumor growth in BALB/c nude mice, which was found to be autophagy dependent. Taken together, our results demonstrate that leptin-induced tumor growth is mediated by autophagy induction and autophagic process would be a promising target to regulate development of cancer caused by leptin production.

  12. Model of socio-cultural dimensions involved in adherence to antiretroviral therapy for HIV/AIDS in public health care centers in Chile.

    Science.gov (United States)

    Stuardo Ávila, Valeria; Manriquez Urbina, Jose Manuel; Fajreldin Chuaqui, Valentina; Belmar Prieto, Julieta; Valenzuela Santibáñez, Victoria

    2016-11-01

    In Chile, over 14,000 adults are living with HIV receive antiretroviral therapy (HAART). Adequate adherence to HAART has a major impact on survival. There is little consensus on the causes of poor adherence, due to the unique and diverse sociocultural parameters involved in the issue. The objective of this study was to identify sociocultural dimensions that serve as barriers or facilitators to HAART adherence among persons living with HIV/AIDS (PLHIV) in Chile. A qualitative study design, with an exploratory followed by a descriptive phase was conducted. The study population consisted of adults living with HIV/AIDS, with and without HAART. A theoretical sample was designed and three gender profiles defined: women, men, and transwomen. Data collection methods included in-depth interviews by anthropologists in seven public health care centers for PLHIV. The model of sociocultural dimensions indicated that factors associated with family, expectations, gender/sexuality, affect, relationship with HIV, HAART, work, social support and networks, and stigma and discrimination influenced adherence, with different patterns among profiles. This study found that adherence is a dynamic category. It is crucial to consider sociocultural factors in developing strategies to improve HAART adherence.

  13. Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: Involvement of p53/FoxO3A axis

    Science.gov (United States)

    Nepal, Saroj; Kim, Mi Jin; Hong, Jin Tae; Kim, Sang Hyun; Sohn, Dong-Hwan; Lee, Sung Hee; Song, Kyung; Choi, Dong Young; Lee, Eung Seok; Park, Pil-Hoon

    2015-01-01

    Leptin, a hormone mainly produced from adipose tissue, has been shown to induce proliferation of cancer cells. However, the molecular mechanisms underlying leptin-induced tumor progression have not been clearly elucidated. In the present study, we investigated the role of autophagy in leptin-induced cancer cell proliferation using human hepatoma (HepG2) and breast cancer cells (MCF-7), and tumor growth in a xenograft model. Herein, we showed that leptin treatment caused autophagy induction as assessed by increase in expression of autophagy-related genes, including beclin-1, Atg5 and LC3 II, further induction of autophagosome formation and autophagic flux. Interestingly, inhibition of autophagic process by treatment with inhibitors and LC3B gene silencing blocked leptin-induced increase in cell number and suppression of apoptosis, indicating a crucial role of autophagy in leptin-induced tumor progression. Moreover, gene silencing of p53 or FoxO3A prevented leptin-induced LC3 II protein expression, suggesting an involvement of p53/FoxO3A axis in leptin-induced autophagy activation. Leptin administration also accelerated tumor growth in BALB/c nude mice, which was found to be autophagy dependent. Taken together, our results demonstrate that leptin-induced tumor growth is mediated by autophagy induction and autophagic process would be a promising target to regulate development of cancer caused by leptin production. PMID:25704884

  14. Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor.

    Science.gov (United States)

    Martins, Daniel F; Prado, Marcos R B; Daruge-Neto, Eduardo; Batisti, Ana P; Emer, Aline A; Mazzardo-Martins, Leidiane; Santos, Adair R S; Piovezan, Anna P

    2015-12-01

    This study was designed to determine whether 3 weeks of gabapentin treatment is effective in alleviating neuropathic pain-like behavior in animal models of complex regional pain syndrome type-I and partial sciatic nerve ligation (PSNL). We investigated the contribution of adenosine subtypes to the antihyperalgesic effect of gabapentin by examining the effect of caffeine, a non-selective adenosine A1 and A2 receptor antagonist or 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a selective adenosine A1 subtype receptor antagonist on this effect. Neuropathic pain was produced by unilateral prolonged hind paw ischemia and reperfusion (I/R) or PSNL procedures which resulted in stimulus-evoked mechanical hyperalgesia. After procedures, animals received gabapentin (10, 30, or 100 mg/kg intraperitoneal, respectively), caffeine (10 mg/kg intraperitoneal or 150 nmol intrathecally) or DPCPX (3 µg intrathecally) alone or in combination. Mice were tested for tactile mechanical hyperalgesia at 1, 2, and 3 weeks following procedures. Gabapentin produced dose-related inhibition of mechanical hyperalgesia over a 3-week period, and this effect was blocked by concomitant caffeine or DPCPX administration 1 week after injuries. The results of this study demonstrated that the mechanism through which gabapentin produces its effect may involve the activation of adenosine A1 subtype receptor.

  15. Fostering an Interest in Science in a Typically Underrepresented Population

    Science.gov (United States)

    Davis, Sarah F.; McEntire, Jennifer Cleveland; Sarakatsannis, James

    2007-01-01

    This "case study" details how food science was introduced into the classrooms of a typically underrepresented population. James Sarakatsannis, an 8th grade physical science teacher, was planning a unit that would use fast food to teach science to his classes, when he came across the Institute of Food Technologists (IFT) website and a wealth of…

  16. The simulation study of three typical time frequency analysis methods

    Directory of Open Access Journals (Sweden)

    Li Yifeng

    2017-01-01

    Full Text Available The principals and characteristics of three typical time frequency analysis methods that Short Time Furious transformation, wavelet transformation and Hilbert-Huang transformation are introduced, and the mathematical definition, characteristics and application ranges of these analysis methods and so on are pointed out, then their time-frequency local performance is made analysis and comparison through computer programming and simulation.

  17. Quantum typicality in spin network states of quantum geometry

    CERN Document Server

    Anzà, Fabio

    2016-01-01

    In this letter we extend the so-called typicality approach, originally formulated in statistical mechanics contexts, to SU(2) invariant spin network states. Our results do not depend on the physical interpretation of the spin-network, however they are mainly motivated by the fact that spin-network states can describe states of quantum geometry, providing a gauge-invariant basis for the kinematical Hilbert space of several background independent approaches to quantum gravity. The first result is, by itself, the existence of a regime in which we show the emergence of a typical state. We interpret this as the prove that, in that regime there are certain (local) properties of quantum geometry which are "universal". Such set of properties is heralded by the typical state, of which we give the explicit form. This is our second result. In the end, we study some interesting properties of the typical state, proving that the area-law for the entropy of a surface must be satisfied at the local level, up to logarithmic c...

  18. Breast Metastases from Extramammary Malignancies: Typical and Atypical Ultrasound Features

    Energy Technology Data Exchange (ETDEWEB)

    Mun, Sung Hee [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710 (Korea, Republic of); Department of Radiology, Catholic University of Daegu College of Medicine, Daegu 712-702 (Korea, Republic of); Ko, Eun Young; Han, Boo-Kyung; Shin, Jung Hee [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710 (Korea, Republic of); Kim, Suk Jung [Department of Radiology, Inje University College of Medicine, Busan Paik Hospital, Busan 614-735 (Korea, Republic of); Cho, Eun Yoon [Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710 (Korea, Republic of)

    2014-07-01

    Breast metastases from extramammary malignancies are uncommon. The most common sources are lymphomas/leukemias and melanomas. Some of the less common sources include carcinomas of the lung, ovary, and stomach, and infrequently, carcinoid tumors, hypernephromas, carcinomas of the liver, tonsil, pleura, pancreas, cervix, perineum, endometrium and bladder. Breast metastases from extramammary malignancies have both hematogenous and lymphatic routes. According to their routes, there are common radiological features of metastatic diseases of the breast, but the features are not specific for metastases. Typical ultrasound (US) features of hematogenous metastases include single or multiple, round to oval shaped, well-circumscribed hypoechoic masses without spiculations, calcifications, or architectural distortion; these masses are commonly located superficially in subcutaneous tissue or immediately adjacent to the breast parenchyma that is relatively rich in blood supply. Typical US features of lymphatic breast metastases include diffusely and heterogeneously increased echogenicities in subcutaneous fat and glandular tissue and a thick trabecular pattern with secondary skin thickening, lymphedema, and lymph node enlargement. However, lesions show variable US features in some cases, and differentiation of these lesions from primary breast cancer or from benign lesions is difficult. In this review, we demonstrate various US appearances of breast metastases from extramammary malignancies as typical and atypical features, based on the results of US and other imaging studies performed at our institution. Awareness of the typical and atypical imaging features of these lesions may be helpful to diagnose metastatic lesions of the breast.

  19. 28 CFR 61.5 - Typical classes of action.

    Science.gov (United States)

    2010-07-01

    ... NATIONAL ENVIRONMENTAL POLICY ACT Implementing Procedures § 61.5 Typical classes of action. (a) The NEPA.... These classes are: actions normally requiring environmental impact statements (EIS), actions normally...; (ii) Proposals for legislation developed by or with the significant cooperation and support of...

  20. Human Behavior, Learning, and the Developing Brain: Typical Development

    Science.gov (United States)

    Coch, Donna, Ed.; Fischer, Kurt W., Ed.; Dawson, Geraldine, Ed.

    2010-01-01

    This volume brings together leading authorities from multiple disciplines to examine the relationship between brain development and behavior in typically developing children. Presented are innovative cross-sectional and longitudinal studies that shed light on brain-behavior connections in infancy and toddlerhood through adolescence. Chapters…

  1. Typical School Day Experiences of Indian Children in Different Contexts.

    Science.gov (United States)

    Jaya, N.; Malar, G.

    2003-01-01

    Notes that India has experienced conditions that have lead to significant illiteracy, but that commitment to education can be found in lesser-known parts of India today. Profiles three schools in Tamil Nadu and describes a typical school day for a student with special needs, a student in a tribal setting, and a student in a rural setting. (TJQ)

  2. Stimulus Overselectivity in Autism, Down Syndrome, and Typical Development

    Science.gov (United States)

    Dube, William V.; Farber, Rachel S.; Mueller, Marlana R.; Grant, Eileen; Lorin, Lucy; Deutsch, Curtis K.

    2016-01-01

    Stimulus overselectivity refers to maladaptive narrow attending that is a common learning problem among children with intellectual disabilities and frequently associated with autism. The present study contrasted overselectivity among groups of children with autism, Down syndrome, and typical development. The groups with autism and Down syndrome…

  3. Typical Lexical and Syntactical Mistakes in Technical Treatises

    Directory of Open Access Journals (Sweden)

    Dalia Gedzevičienė

    2011-02-01

    Full Text Available The present article suggests the analysis of typical mechanically made lexical and syntactical mistakes appearing in treatises. The article also provides the examples of mistakes found in this book. Causes for language mistakes (mistakes in using the wrong words, cases and prepositions and correction of errors are given.Article in Lithuanian

  4. The Roots of Disillusioned American Dream in Typical American

    Institute of Scientific and Technical Information of China (English)

    古冬华

    2016-01-01

    Typical American is one of Gish Jen’s notable novels catching attention of the American literary circle. The motif of disillusioned American dream can be seen clearly through the experiences of three main characters. From perspectives of the consumer culture and cultural conflicts, this paper analyzes the roots of the disillusioned American dream in the novel.

  5. Realizing the Typical Gas Burning System' s Control by PLC

    Institute of Scientific and Technical Information of China (English)

    Zhang,Hengcheng; Wang,Yanbin

    2003-01-01

    This Paper introduced the typical gas burning sys-tem's cemposing, analysesed and discussed its operation theoryand two different leak control methods in detail, investigatedconcretely the software and hardware design project of realizingcontrol and performed communication with upper computer bySiemens' s S7-300 Programmable Logical Controller.

  6. Describing Typical Capstone Course Experiences from a National Random Sample

    Science.gov (United States)

    Grahe, Jon E.; Hauhart, Robert C.

    2013-01-01

    The pedagogical value of capstones has been regularly discussed within psychology. This study presents results from an examination of a national random sample of department webpages and an online survey that characterized the typical capstone course in terms of classroom activities and course administration. The department webpages provide an…

  7. Face-to-Face Interference in Typical and Atypical Development

    Science.gov (United States)

    Riby, Deborah M.; Doherty-Sneddon, Gwyneth; Whittle, Lisa

    2012-01-01

    Visual communication cues facilitate interpersonal communication. It is important that we look at faces to retrieve and subsequently process such cues. It is also important that we sometimes look away from faces as they increase cognitive load that may interfere with online processing. Indeed, when typically developing individuals hold face gaze…

  8. Whittaker categories and strongly typical Whittaker modules for Lie superalgebras

    CERN Document Server

    Bagci, Irfan; Wiesner, Emilie

    2012-01-01

    Following analogous constructions for Lie algebras, we define Whittaker modules and Whittaker categories for finite-dimensional simple Lie superalgebras. Results include a decomposition of Whittaker categories for a Lie superalgebra according to the action of an appropriate sub-superalgebra; and, for basic classical Lie superalgebras of type I, a description of the strongly typical simple Whittaker modules.

  9. BRONCHOSCOPIC THERAPY IN PATIENTS WITH INTRALUMINAL TYPICAL BRONCHIAL CARCINOID

    NARCIS (Netherlands)

    SUTEDJA, TG; SCHREURS, AJ; VANDERSCHUEREN, RG; KWA, B; VANDERWERF, TS; POSTMUS, PE

    1995-01-01

    Objective: To study the efficacy of bronchoscopic therapy in patients with intraluminal typical bronchial carcinoid. Design: Retrospective analysis of the data of patients with bronchial carcinoid, treated primarily with bronchoscopic techniques such as Nd-YAG laser in various hospitals in the Nethe

  10. Typical neuroleptic malignant syndrome presented in patient on maintenance quetiapine

    Directory of Open Access Journals (Sweden)

    Chintan Madhusudan Raval

    2014-01-01

    Full Text Available Neuroleptic malignant syndrome is an acute, life-threatening medical complication caused by antipsychotics. It is commonly seen with typical antipsychotics and very rare with atypicals. Cases have been reported with quetiapine also, but this case is of special interest because it occurred in patient who was stable on maintenance quetiapine 200 mg/day for last 5 years.

  11. Temperament Dimensions in Stuttering and Typically Developing Children

    Science.gov (United States)

    Eggers, Kurt; De Nil, Luc F.; Van den Bergh, Bea R. H.

    2010-01-01

    Purpose: The purpose of this study was to determine whether children who stutter (CWS) and typically developing children (TDC) differ from each other on composite temperament factors or on individual temperament scales. Methods: Participants consisted of 116 age and gender-matched CWS and TDC (3.04-8.11). Temperament was assessed with a Dutch…

  12. Human Behavior, Learning, and the Developing Brain: Typical Development

    Science.gov (United States)

    Coch, Donna, Ed.; Fischer, Kurt W., Ed.; Dawson, Geraldine, Ed.

    2010-01-01

    This volume brings together leading authorities from multiple disciplines to examine the relationship between brain development and behavior in typically developing children. Presented are innovative cross-sectional and longitudinal studies that shed light on brain-behavior connections in infancy and toddlerhood through adolescence. Chapters…

  13. Sonographic findings of typical and atypical scrotal trauma.

    Science.gov (United States)

    Sommers, Daniel N; Jensen, Jeff

    2015-06-01

    This review article illustrates sonographic findings in the setting of accidental and nonaccidental scrotal trauma. Although sonographic findings may be irrespective of the type of trauma, the goals of sonographic evaluation are similar in both atypical and typical mechanisms of scrotal injury. Familiarity with findings such as disruption of testicular integrity or vascularity facilitates prompt diagnosis and plays a critical role in clinical management.

  14. On the entailment problem for a logic of typicality

    CSIR Research Space (South Africa)

    Booth, R

    2015-07-01

    Full Text Available , Buenos Aires, Argentina, 25-31 July 2015 On the entailment problem for a logic of typicality Richard Booth Mahasarakham University Thailand ribooth@gmail.com Giovanni Casini CAIR, Univ. of Pretoria and CSIR Meraka South Africa; Univ...

  15. Breaking soliton equations and negative-order breaking soliton equations of typical and higher orders

    Indian Academy of Sciences (India)

    ABDUL-MAJID WAZWAZ

    2016-11-01

    We develop breaking soliton equations and negative-order breaking soliton equations of typical and higher orders. The recursion operator of the KdV equation is used to derive these models.We establish the distinctdispersion relation for each equation. We use the simplified Hirota’s method to obtain multiple soliton solutions for each developed breaking soliton equation. We also develop generalized dispersion relations for the typical breaking soliton equations and the generalized negative-order breaking soliton equations. The results provide useful information on the dynamics of the relevant nonlinear negative-order equations.

  16. 基于CMIP5全球气候模式的中国典型区域干湿变化分析%Analysis of dry and wet variations in typical regions of China based on a CMIP5 global climate model

    Institute of Scientific and Technical Information of China (English)

    姜姗姗; 占车生; 李淼; 王飞宇; 梁伟

    2016-01-01

    基于CMIP5多全球气候模式数值模拟结果,包括空间分辨率0.5°的逐月历史气候数据和 RCP2.6、RCP4.5、RCP8.5情景下未来气候变化预估数据,利用潜在蒸散发和降水量构建能够表征地表干湿状况的湿润指数,对中国东部季风区7个典型区1901—2100年干湿变化趋势进行了模拟和分析.结果表明:各分区在1901—2005年湿润指数均呈现下降趋势,其中珠江、长江、淮河流域变化较为平缓,黄河、海河流域和东北地区波动较大.可见在过去的100多年中,东部季风区整体上呈现不同程度的干旱化.在2006—2100年不同温室气体排放情景下,各分区的湿润指数呈现不同程度的波动,除了黄河上游地区湿润指数呈现增长趋势外,其他区域没有明显的变湿趋势.%Global climate model data,including historical climate simulation data and RCP2.6 ,RCP4.5 and RCP8.5 future estimation data from The Fifth Phase of the Coupled Model Intercomparison Proj ect (CMIP5)were used to analyze the dry/wet variations of seven typical areas of the East Monsoon Area of China from 1901—2100 on a humid index detecting the dry/wet condition at the surface.It was found that from 1901—2005,the humid index in each partition gradually decreased.The humid index decreased slowly in the Pearl River,Yangtze River,Huaihe River,and downstream of the Yellow River.The humid index was volatile in the Yellow River,Haihe River and the northeastern region.Therefore in the past 100 years,the East Monsoon Area of China was in drought condition.The model predicts that from 2006—2100,under different scenarios of greenhouse gas emission,the humid index in all partition will be volatile,while upstream of the Yellow River the humid index will gradually increase from 2006 to 2100,changes in the remaining regions will not be significant.

  17. Using Video Modeling to Teach Reciprocal Pretend Play to Children with Autism

    Science.gov (United States)

    MacDonald, Rebecca; Sacramone, Shelly; Mansfield, Renee; Wiltz, Kristine; Ahearn, William H.

    2009-01-01

    The purpose of the present study was to use video modeling to teach children with autism to engage in reciprocal pretend play with typically developing peers. Scripted play scenarios involving various verbalizations and play actions with adults as models were videotaped. Two children with autism were each paired with a typically developing child,…

  18. The proinflammatory RAGE/NF-κB pathway is involved in neuronal damage and reactive gliosis in a model of sleep apnea by intermittent hypoxia.

    Directory of Open Access Journals (Sweden)

    Maria Florencia Angelo

    Full Text Available Sleep apnea (SA causes long-lasting changes in neuronal circuitry, which persist even in patients successfully treated for the acute effects of the disease. Evidence obtained from the intermittent hypoxia (IH experimental model of SA has shown neuronal death, impairment in learning and memory and reactive gliosis that may account for cognitive and structural alterations observed in human patients. However, little is known about the mechanism controlling these deleterious effects that may be useful as therapeutic targets in SA. The Receptor for Advanced Glycation End products (RAGE and its downstream effector Nuclear Factor Kappa B (NF-κB have been related to neuronal death and astroglial conversion to the pro-inflammatory neurodegenerative phenotype. RAGE expression and its ligand S100B were shown to be increased in experimental models of SA. We here used dissociated mixed hippocampal cell cultures and male Wistar rats exposed to IH cycles and observed that NF-κB is activated in glial cells and neurons after IH. To disclose the relative contribution of the S100B/RAGE/NF-κB pathway to neuronal damage and reactive gliosis after IH we performed sequential loss of function studies using RAGE or S100B neutralizing antibodies, a herpes simplex virus (HSV-derived amplicon vector that induces the expression of RAGEΔcyto (dominant negative RAGE and a chemical blocker of NF-κB. Our results show that NF-κB activation peaks 3 days after IH exposure, and that RAGE or NF-κB blockage during this critical period significantly improves neuronal survival and reduces reactive gliosis. Both in vitro and in vivo, S100B blockage altered reactive gliosis but did not have significant effects on neuronal survival. We conclude that both RAGE and downstream NF-κB signaling are centrally involved in the neuronal alterations found in SA models, and that blockage of these pathways is a tempting strategy for preventing neuronal degeneration and reactive gliosis in SA.

  19. Time to discontinuation of atypical versus typical antipsychotics in the naturalistic treatment of schizophrenia

    Directory of Open Access Journals (Sweden)

    Swartz Marvin

    2006-02-01

    Full Text Available Abstract Background There is an ongoing debate over whether atypical antipsychotics are more effective than typical antipsychotics in the treatment of schizophrenia. This naturalistic study compares atypical and typical antipsychotics on time to all-cause medication discontinuation, a recognized index of medication effectiveness in the treatment of schizophrenia. Methods We used data from a large, 3-year, observational, non-randomized, multisite study of schizophrenia, conducted in the U.S. between 7/1997 and 9/2003. Patients who were initiated on oral atypical antipsychotics (clozapine, olanzapine, risperidone, quetiapine, or ziprasidone or oral typical antipsychotics (low, medium, or high potency were compared on time to all-cause medication discontinuation for 1 year following initiation. Treatment group comparisons were based on treatment episodes using 3 statistical approaches (Kaplan-Meier survival analysis, Cox Proportional Hazards regression model, and propensity score-adjusted bootstrap resampling methods. To further assess the robustness of the findings, sensitivity analyses were performed, including the use of (a only 1 medication episode for each patient, the one with which the patient was treated first, and (b all medication episodes, including those simultaneously initiated on more than 1 antipsychotic. Results Mean time to all-cause medication discontinuation was longer on atypical (N = 1132, 256.3 days compared to typical antipsychotics (N = 534, 197.2 days; p Conclusion In the usual care of schizophrenia patients, time to medication discontinuation for any cause appears significantly longer for atypical than typical antipsychotics regardless of the typical antipsychotic potency level. Findings were primarily driven by clozapine and olanzapine, and to a lesser extent by risperidone. Furthermore, only clozapine and olanzapine therapy showed consistently and significantly longer treatment duration compared to perphenazine, a medium

  20. Brain bases of reading fluency in typical reading and impaired fluency in dyslexia.

    Science.gov (United States)

    Christodoulou, Joanna A; Del Tufo, Stephanie N; Lymberis, John; Saxler, Patricia K; Ghosh, Satrajit S; Triantafyllou, Christina; Whitfield-Gabrieli, Susan; Gabrieli, John D E

    2014-01-01

    Although the neural systems supporting single word reading are well studied, there are limited direct comparisons between typical and dyslexic readers of the neural correlates of reading fluency. Reading fluency deficits are a persistent behavioral marker of dyslexia into adulthood. The current study identified the neural correlates of fluent reading in typical and dyslexic adult readers, using sentences presented in a word-by-word format in which single words were presented sequentially at fixed rates. Sentences were presented at slow, medium, and fast rates, and participants were asked to decide whether each sentence did or did not make sense semantically. As presentation rates increased, participants became less accurate and slower at making judgments, with comprehension accuracy decreasing disproportionately for dyslexic readers. In-scanner performance on the sentence task correlated significantly with standardized clinical measures of both reading fluency and phonological awareness. Both typical readers and readers with dyslexia exhibited widespread, bilateral increases in activation that corresponded to increases in presentation rate. Typical readers exhibited significantly larger gains in activation as a function of faster presentation rates than readers with dyslexia in several areas, including left prefrontal and left superior temporal regions associated with semantic retrieval and semantic and phonological representations. Group differences were more extensive when behavioral differences between conditions were equated across groups. These findings suggest a brain basis for impaired reading fluency in dyslexia, specifically a failure of brain regions involved in semantic retrieval and semantic and phonological representations to become fully engaged for comprehension at rapid reading rates.