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Sample records for models successfully reproduce

  1. Coupled RipCAS-DFLOW (CoRD) Software and Data Management System for Reproducible Floodplain Vegetation Succession Modeling

    Science.gov (United States)

    Turner, M. A.; Miller, S.; Gregory, A.; Cadol, D. D.; Stone, M. C.; Sheneman, L.

    2016-12-01

    We present the Coupled RipCAS-DFLOW (CoRD) modeling system created to encapsulate the workflow to analyze the effects of stream flooding on vegetation succession. CoRD provides an intuitive command-line and web interface to run DFLOW and RipCAS in succession over many years automatically, which is a challenge because, for our application, DFLOW must be run on a supercomputing cluster via the PBS job scheduler. RipCAS is a vegetation succession model, and DFLOW is a 2D open channel flow model. Data adaptors have been developed to seamlessly connect DFLOW output data to be RipCAS inputs, and vice-versa. CoRD provides automated statistical analysis and visualization, plus automatic syncing of input and output files and model run metadata to the hydrological data management system HydroShare using its excellent Python REST client. This combination of technologies and data management techniques allows the results to be shared with collaborators and eventually published. Perhaps most importantly, it allows results to be easily reproduced via either the command-line or web user interface. This system is a result of collaboration between software developers and hydrologists participating in the Western Consortium for Watershed Analysis, Visualization, and Exploration (WC-WAVE). Because of the computing-intensive nature of this particular workflow, including automating job submission/monitoring and data adaptors, software engineering expertise is required. However, the hydrologists provide the software developers with a purpose and ensure a useful, intuitive tool is developed. Our hydrologists contribute software, too: RipCAS was developed from scratch by hydrologists on the team as a specialized, open-source version of the Computer Aided Simulation Model for Instream Flow and Riparia (CASiMiR) vegetation model; our hydrologists running DFLOW provided numerous examples and help with the supercomputing system. This project is written in Python, a popular language in the

  2. Successful modeling?

    Science.gov (United States)

    Lomnitz, Cinna

    Tichelaar and Ruff [1989] propose to “estimate model variance in complicated geophysical problems,” including the determination of focal depth in earthquakes, by means of unconventional statistical methods such as bootstrapping. They are successful insofar as they are able to duplicate the results from more conventional procedures.

  3. Reproducibility in Computational Neuroscience Models and Simulations

    Science.gov (United States)

    McDougal, Robert A.; Bulanova, Anna S.; Lytton, William W.

    2016-01-01

    Objective Like all scientific research, computational neuroscience research must be reproducible. Big data science, including simulation research, cannot depend exclusively on journal articles as the method to provide the sharing and transparency required for reproducibility. Methods Ensuring model reproducibility requires the use of multiple standard software practices and tools, including version control, strong commenting and documentation, and code modularity. Results Building on these standard practices, model sharing sites and tools have been developed that fit into several categories: 1. standardized neural simulators, 2. shared computational resources, 3. declarative model descriptors, ontologies and standardized annotations; 4. model sharing repositories and sharing standards. Conclusion A number of complementary innovations have been proposed to enhance sharing, transparency and reproducibility. The individual user can be encouraged to make use of version control, commenting, documentation and modularity in development of models. The community can help by requiring model sharing as a condition of publication and funding. Significance Model management will become increasingly important as multiscale models become larger, more detailed and correspondingly more difficult to manage by any single investigator or single laboratory. Additional big data management complexity will come as the models become more useful in interpreting experiments, thus increasing the need to ensure clear alignment between modeling data, both parameters and results, and experiment. PMID:27046845

  4. A reproducible canine model of esophageal varices.

    Science.gov (United States)

    Jensen, D M; Machicado, G A; Tapia, J I; Kauffman, G; Franco, P; Beilin, D

    1983-03-01

    One of the most promising nonoperative techniques for control of variceal hemorrhage is sclerosis via the fiberoptic endoscope. Many questions remain, however, about sclerosing agents, guidelines for effective use, and limitations of endoscopic techniques. A reproducible large animal model of esophageal varices would facilitate the critical evaluation of techniques for variceal hemostasis or sclerosis. Our purpose was to develop a large animal model of esophageal varices. Studies in pigs and dogs are described which led to the development of a reproducible canine model of esophageal varices. For the final model, mongrel dogs had laparotomy, side-to-side portacaval shunt, inferior vena cava ligation, placement of an ameroid constrictor around the portal vein, and liver biopsy. The mean (+/- SE) pre- and postshunt portal pressure increased significantly from 12 +/- 0.4 to 23 +/- 1 cm saline. Weekly endoscopies were performed to grade the varix size. Two-thirds of animals developed medium or large sized esophageal varices after the first operation. Three to six weeks later, a second laparotomy with complete ligation of the portal vein and liver biopsy were performed in animals with varices (one-third of the animals). All dogs developed esophageal varices and abdominal wall collateral veins of variable size 3-6 wk after the first operation. After the second operation, the varices became larger. Shunting of blood through esophageal varices via splenic and gastric veins was demonstrated by angiography. Sequential liver biopsies were normal. There was no morbidity or mortality. Ascites, encephalopathy, or spontaneous variceal bleeding did not occur. We have documented the lack of size change and the persistence of medium to large esophageal varices and abdominal collateral veins in all animals followed for more than 6 mo. Variceal bleeding could be induced by venipuncture for testing endoscopic hemostatic and sclerosis methods. We suggest other potential uses of this

  5. Modeling reproducibility of porescale multiphase flow experiments

    Science.gov (United States)

    Ling, B.; Tartakovsky, A. M.; Bao, J.; Oostrom, M.; Battiato, I.

    2017-12-01

    Multi-phase flow in porous media is widely encountered in geological systems. Understanding immiscible fluid displacement is crucial for processes including, but not limited to, CO2 sequestration, non-aqueous phase liquid contamination and oil recovery. Microfluidic devices and porescale numerical models are commonly used to study multiphase flow in biological, geological, and engineered porous materials. In this work, we perform a set of drainage and imbibition experiments in six identical microfluidic cells to study the reproducibility of multiphase flow experiments. We observe significant variations in the experimental results, which are smaller during the drainage stage and larger during the imbibition stage. We demonstrate that these variations are due to sub-porescale geometry differences in microcells (because of manufacturing defects) and variations in the boundary condition (i.e.,fluctuations in the injection rate inherent to syringe pumps). Computational simulations are conducted using commercial software STAR-CCM+, both with constant and randomly varying injection rate. Stochastic simulations are able to capture variability in the experiments associated with the varying pump injection rate.

  6. How Modeling Standards, Software, and Initiatives Support Reproducibility in Systems Biology and Systems Medicine.

    Science.gov (United States)

    Waltemath, Dagmar; Wolkenhauer, Olaf

    2016-10-01

    Only reproducible results are of significance to science. The lack of suitable standards and appropriate support of standards in software tools has led to numerous publications with irreproducible results. Our objectives are to identify the key challenges of reproducible research and to highlight existing solutions. In this paper, we summarize problems concerning reproducibility in systems biology and systems medicine. We focus on initiatives, standards, and software tools that aim to improve the reproducibility of simulation studies. The long-term success of systems biology and systems medicine depends on trustworthy models and simulations. This requires openness to ensure reusability and transparency to enable reproducibility of results in these fields.

  7. Towards reproducible descriptions of neuronal network models.

    Directory of Open Access Journals (Sweden)

    Eilen Nordlie

    2009-08-01

    Full Text Available Progress in science depends on the effective exchange of ideas among scientists. New ideas can be assessed and criticized in a meaningful manner only if they are formulated precisely. This applies to simulation studies as well as to experiments and theories. But after more than 50 years of neuronal network simulations, we still lack a clear and common understanding of the role of computational models in neuroscience as well as established practices for describing network models in publications. This hinders the critical evaluation of network models as well as their re-use. We analyze here 14 research papers proposing neuronal network models of different complexity and find widely varying approaches to model descriptions, with regard to both the means of description and the ordering and placement of material. We further observe great variation in the graphical representation of networks and the notation used in equations. Based on our observations, we propose a good model description practice, composed of guidelines for the organization of publications, a checklist for model descriptions, templates for tables presenting model structure, and guidelines for diagrams of networks. The main purpose of this good practice is to trigger a debate about the communication of neuronal network models in a manner comprehensible to humans, as opposed to machine-readable model description languages. We believe that the good model description practice proposed here, together with a number of other recent initiatives on data-, model-, and software-sharing, may lead to a deeper and more fruitful exchange of ideas among computational neuroscientists in years to come. We further hope that work on standardized ways of describing--and thinking about--complex neuronal networks will lead the scientific community to a clearer understanding of high-level concepts in network dynamics, and will thus lead to deeper insights into the function of the brain.

  8. Can a coupled meteorology–chemistry model reproduce the ...

    Science.gov (United States)

    The ability of a coupled meteorology–chemistry model, i.e., Weather Research and Forecast and Community Multiscale Air Quality (WRF-CMAQ), to reproduce the historical trend in aerosol optical depth (AOD) and clear-sky shortwave radiation (SWR) over the Northern Hemisphere has been evaluated through a comparison of 21-year simulated results with observation-derived records from 1990 to 2010. Six satellite-retrieved AOD products including AVHRR, TOMS, SeaWiFS, MISR, MODIS-Terra and MODIS-Aqua as well as long-term historical records from 11 AERONET sites were used for the comparison of AOD trends. Clear-sky SWR products derived by CERES at both the top of atmosphere (TOA) and surface as well as surface SWR data derived from seven SURFRAD sites were used for the comparison of trends in SWR. The model successfully captured increasing AOD trends along with the corresponding increased TOA SWR (upwelling) and decreased surface SWR (downwelling) in both eastern China and the northern Pacific. The model also captured declining AOD trends along with the corresponding decreased TOA SWR (upwelling) and increased surface SWR (downwelling) in the eastern US, Europe and the northern Atlantic for the period of 2000–2010. However, the model underestimated the AOD over regions with substantial natural dust aerosol contributions, such as the Sahara Desert, Arabian Desert, central Atlantic and northern Indian Ocean. Estimates of the aerosol direct radiative effect (DRE) at TOA a

  9. Development of a Consistent and Reproducible Porcine Scald Burn Model

    Science.gov (United States)

    Kempf, Margit; Kimble, Roy; Cuttle, Leila

    2016-01-01

    There are very few porcine burn models that replicate scald injuries similar to those encountered by children. We have developed a robust porcine burn model capable of creating reproducible scald burns for a wide range of burn conditions. The study was conducted with juvenile Large White pigs, creating replicates of burn combinations; 50°C for 1, 2, 5 and 10 minutes and 60°C, 70°C, 80°C and 90°C for 5 seconds. Visual wound examination, biopsies and Laser Doppler Imaging were performed at 1, 24 hours and at 3 and 7 days post-burn. A consistent water temperature was maintained within the scald device for long durations (49.8 ± 0.1°C when set at 50°C). The macroscopic and histologic appearance was consistent between replicates of burn conditions. For 50°C water, 10 minute duration burns showed significantly deeper tissue injury than all shorter durations at 24 hours post-burn (p ≤ 0.0001), with damage seen to increase until day 3 post-burn. For 5 second duration burns, by day 7 post-burn the 80°C and 90°C scalds had damage detected significantly deeper in the tissue than the 70°C scalds (p ≤ 0.001). A reliable and safe model of porcine scald burn injury has been successfully developed. The novel apparatus with continually refreshed water improves consistency of scald creation for long exposure times. This model allows the pathophysiology of scald burn wound creation and progression to be examined. PMID:27612153

  10. Cyberinfrastructure to Support Collaborative and Reproducible Computational Hydrologic Modeling

    Science.gov (United States)

    Goodall, J. L.; Castronova, A. M.; Bandaragoda, C.; Morsy, M. M.; Sadler, J. M.; Essawy, B.; Tarboton, D. G.; Malik, T.; Nijssen, B.; Clark, M. P.; Liu, Y.; Wang, S. W.

    2017-12-01

    Creating cyberinfrastructure to support reproducibility of computational hydrologic models is an important research challenge. Addressing this challenge requires open and reusable code and data with machine and human readable metadata, organized in ways that allow others to replicate results and verify published findings. Specific digital objects that must be tracked for reproducible computational hydrologic modeling include (1) raw initial datasets, (2) data processing scripts used to clean and organize the data, (3) processed model inputs, (4) model results, and (5) the model code with an itemization of all software dependencies and computational requirements. HydroShare is a cyberinfrastructure under active development designed to help users store, share, and publish digital research products in order to improve reproducibility in computational hydrology, with an architecture supporting hydrologic-specific resource metadata. Researchers can upload data required for modeling, add hydrology-specific metadata to these resources, and use the data directly within HydroShare.org for collaborative modeling using tools like CyberGIS, Sciunit-CLI, and JupyterHub that have been integrated with HydroShare to run models using notebooks, Docker containers, and cloud resources. Current research aims to implement the Structure For Unifying Multiple Modeling Alternatives (SUMMA) hydrologic model within HydroShare to support hypothesis-driven hydrologic modeling while also taking advantage of the HydroShare cyberinfrastructure. The goal of this integration is to create the cyberinfrastructure that supports hypothesis-driven model experimentation, education, and training efforts by lowering barriers to entry, reducing the time spent on informatics technology and software development, and supporting collaborative research within and across research groups.

  11. Reproducibility and Transparency in Ocean-Climate Modeling

    Science.gov (United States)

    Hannah, N.; Adcroft, A.; Hallberg, R.; Griffies, S. M.

    2015-12-01

    Reproducibility is a cornerstone of the scientific method. Within geophysical modeling and simulation achieving reproducibility can be difficult, especially given the complexity of numerical codes, enormous and disparate data sets, and variety of supercomputing technology. We have made progress on this problem in the context of a large project - the development of new ocean and sea ice models, MOM6 and SIS2. Here we present useful techniques and experience.We use version control not only for code but the entire experiment working directory, including configuration (run-time parameters, component versions), input data and checksums on experiment output. This allows us to document when the solutions to experiments change, whether due to code updates or changes in input data. To avoid distributing large input datasets we provide the tools for generating these from the sources, rather than provide raw input data.Bugs can be a source of non-determinism and hence irreproducibility, e.g. reading from or branching on uninitialized memory. To expose these we routinely run system tests, using a memory debugger, multiple compilers and different machines. Additional confidence in the code comes from specialised tests, for example automated dimensional analysis and domain transformations. This has entailed adopting a code style where we deliberately restrict what a compiler can do when re-arranging mathematical expressions.In the spirit of open science, all development is in the public domain. This leads to a positive feedback, where increased transparency and reproducibility makes using the model easier for external collaborators, who in turn provide valuable contributions. To facilitate users installing and running the model we provide (version controlled) digital notebooks that illustrate and record analysis of output. This has the dual role of providing a gross, platform-independent, testing capability and a means to documents model output and analysis.

  12. Paleomagnetic analysis of curved thrust belts reproduced by physical models

    Science.gov (United States)

    Costa, Elisabetta; Speranza, Fabio

    2003-12-01

    This paper presents a new methodology for studying the evolution of curved mountain belts by means of paleomagnetic analyses performed on analogue models. Eleven models were designed aimed at reproducing various tectonic settings in thin-skinned tectonics. Our models analyze in particular those features reported in the literature as possible causes for peculiar rotational patterns in the outermost as well as in the more internal fronts. In all the models the sedimentary cover was reproduced by frictional low-cohesion materials (sand and glass micro-beads), which detached either on frictional or on viscous layers. These latter were reproduced in the models by silicone. The sand forming the models has been previously mixed with magnetite-dominated powder. Before deformation, the models were magnetized by means of two permanent magnets generating within each model a quasi-linear magnetic field of intensity variable between 20 and 100 mT. After deformation, the models were cut into closely spaced vertical sections and sampled by means of 1×1-cm Plexiglas cylinders at several locations along curved fronts. Care was taken to collect paleomagnetic samples only within virtually undeformed thrust sheets, avoiding zones affected by pervasive shear. Afterwards, the natural remanent magnetization of these samples was measured, and alternating field demagnetization was used to isolate the principal components. The characteristic components of magnetization isolated were used to estimate the vertical-axis rotations occurring during model deformation. We find that indenters pushing into deforming belts from behind form non-rotational curved outer fronts. The more internal fronts show oroclinal-type rotations of a smaller magnitude than that expected for a perfect orocline. Lateral symmetrical obstacles in the foreland colliding with forward propagating belts produce non-rotational outer curved fronts as well, whereas in between and inside the obstacles a perfect orocline forms

  13. Can global chemistry-climate models reproduce air quality extremes?

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    Schnell, J.; Prather, M. J.; Holmes, C. D.

    2013-12-01

    We identify and characterize extreme ozone pollution episodes over the USA and EU through a novel analysis of ten years (2000-2010) of surface ozone measurements. An optimal interpolation scheme is developed to create grid-cell averaged values of surface ozone that can be compared with gridded model simulations. In addition, it also allows a comparison of two non-coincident observational networks in the EU. The scheme incorporates techniques borrowed from inverse distance weighting and Kriging. It uses all representative observational site data while still recognizing the heterogeneity of surface ozone. Individual, grid-cell level events are identified as an exceedance of historical percentile (10 worst days in a year, 97.3 percentile). A clustering algorithm is then used to construct the ozone episodes from the individual events. We then test the skill of the high-resolution (100 km) two-year (2005-2006) hindcast from the UCI global chemistry transport model in reproducing the events/episodes identified in the observations using the same identification criteria. Although the UCI CTM has substantial biases in surface ozone, we find that it has considerable skill in reproducing both individual grid-cell level extreme events and their connectedness in space and time with an overall skill of 24% (32%) for the US (EU). The grid-cell level extreme ozone events in both the observations and UCI CTM are found to occur mostly (~75%) in coherent, multi-day, connected episodes covering areas greater than 1000 x 1000 square km. In addition the UCI CTM has greater skill in reproducing these larger episodes. We conclude that even at relatively coarse resolution, global chemistry-climate models can be used to project major synoptic pollution episodes driven by large-scale climate and chemistry changes even with their known biases.

  14. From alginate impressions to digital virtual models: accuracy and reproducibility.

    Science.gov (United States)

    Dalstra, Michel; Melsen, Birte

    2009-03-01

    To compare the accuracy and reproducibility of measurements performed on digital virtual models with those taken on plaster casts from models poured immediately after the impression was taken, the 'gold standard', and from plaster models poured following a 3-5 day shipping procedure of the alginate impression. Direct comparison of two measuring techniques. The study was conducted at the Department of Orthodontics, School of Dentistry, University of Aarhus, Denmark in 2006/2007. Twelve randomly selected orthodontic graduate students with informed consent. Three sets of alginate impressions were taken from the participants within 1 hour. Plaster models were poured immediately from two of the sets, while the third set was kept in transit in the mail for 3-5 days. Upon return a plaster model was poured as well. Finally digital models were made from the plaster models. A number of measurements were performed on the plaster casts with a digital calliper and on the corresponding digital models using the virtual measuring tool of the accompanying software. Afterwards these measurements were compared statistically. No statistical differences were found between the three sets of plaster models. The intra- and inter-observer variability are smaller for the measurements performed on the digital models. Sending alginate impressions by mail does not affect the quality and accuracy of plaster casts poured from them afterwards. Virtual measurements performed on digital models display less variability than the corresponding measurements performed with a calliper on the actual models.

  15. A reproducible oral microcosm biofilm model for testing dental materials.

    Science.gov (United States)

    Rudney, J D; Chen, R; Lenton, P; Li, J; Li, Y; Jones, R S; Reilly, C; Fok, A S; Aparicio, C

    2012-12-01

    Most studies of biofilm effects on dental materials use single-species biofilms, or consortia. Microcosm biofilms grown directly from saliva or plaque are much more diverse, but difficult to characterize. We used the Human Oral Microbial Identification Microarray (HOMIM) to validate a reproducible oral microcosm model. Saliva and dental plaque were collected from adults and children. Hydroxyapatite and dental composite discs were inoculated with either saliva or plaque, and microcosm biofilms were grown in a CDC biofilm reactor. In later experiments, the reactor was pulsed with sucrose. DNA from inoculums and microcosms was analysed by HOMIM for 272 species. Microcosms included about 60% of species from the original inoculum. Biofilms grown on hydroxyapatite and composites were extremely similar. Sucrose pulsing decreased diversity and pH, but increased the abundance of Streptococcus and Veillonella. Biofilms from the same donor, grown at different times, clustered together. This model produced reproducible microcosm biofilms that were representative of the oral microbiota. Sucrose induced changes associated with dental caries. This is the first use of HOMIM to validate an oral microcosm model that can be used to study the effects of complex biofilms on dental materials. © 2012 The Society for Applied Microbiology.

  16. Voxel-level reproducibility assessment of modality independent elastography in a pre-clinical murine model

    Science.gov (United States)

    Flint, Katelyn M.; Weis, Jared A.; Yankeelov, Thomas E.; Miga, Michael I.

    2015-03-01

    Changes in tissue mechanical properties, measured non-invasively by elastography methods, have been shown to be an important diagnostic tool, particularly for cancer. Tissue elasticity information, tracked over the course of therapy, may be an important prognostic indicator of tumor response to treatment. While many elastography techniques exist, this work reports on the use of a novel form of elastography that uses image texture to reconstruct elastic property distributions in tissue (i.e., a modality independent elastography (MIE) method) within the context of a pre-clinical breast cancer system.1,2 The elasticity results have previously shown good correlation with independent mechanical testing.1 Furthermore, MIE has been successfully utilized to localize and characterize lesions in both phantom experiments and simulation experiments with clinical data.2,3 However, the reproducibility of this method has not been characterized in previous work. The goal of this study is to evaluate voxel-level reproducibility of MIE in a pre-clinical model of breast cancer. Bland-Altman analysis of co-registered repeat MIE scans in this preliminary study showed a reproducibility index of 24.7% (scaled to a percent of maximum stiffness) at the voxel level. As opposed to many reports in the magnetic resonance elastography (MRE) literature that speak to reproducibility measures of the bulk organ, these results establish MIE reproducibility at the voxel level; i.e., the reproducibility of locally-defined mechanical property measurements throughout the tumor volume.

  17. The substorm cycle as reproduced by global MHD models

    Science.gov (United States)

    Gordeev, E.; Sergeev, V.; Tsyganenko, N.; Kuznetsova, M.; Rastäetter, L.; Raeder, J.; Tóth, G.; Lyon, J.; Merkin, V.; Wiltberger, M.

    2017-01-01

    Recently, Gordeev et al. (2015) suggested a method to test global MHD models against statistical empirical data. They showed that four community-available global MHD models supported by the Community Coordinated Modeling Center (CCMC) produce a reasonable agreement with reality for those key parameters (the magnetospheric size, magnetic field, and pressure) that are directly related to the large-scale equilibria in the outer magnetosphere. Based on the same set of simulation runs, here we investigate how the models reproduce the global loading-unloading cycle. We found that in terms of global magnetic flux transport, three examined CCMC models display systematically different response to idealized 2 h north then 2 h south interplanetary magnetic field (IMF) Bz variation. The LFM model shows a depressed return convection and high loading rate during the growth phase as well as enhanced return convection and high unloading rate during the expansion phase, with the amount of loaded/unloaded magnetotail flux and the growth phase duration being the closest to their observed empirical values during isolated substorms. Two other models exhibit drastically different behavior. In the BATS-R-US model the plasma sheet convection shows a smooth transition to the steady convection regime after the IMF southward turning. In the Open GGCM a weak plasma sheet convection has comparable intensities during both the growth phase and the following slow unloading phase. We also demonstrate potential technical problem in the publicly available simulations which is related to postprocessing interpolation and could affect the accuracy of magnetic field tracing and of other related procedures.

  18. A reproducible brain tumour model established from human glioblastoma biopsies

    Directory of Open Access Journals (Sweden)

    Li Xingang

    2009-12-01

    Full Text Available Abstract Background Establishing clinically relevant animal models of glioblastoma multiforme (GBM remains a challenge, and many commonly used cell line-based models do not recapitulate the invasive growth patterns of patient GBMs. Previously, we have reported the formation of highly invasive tumour xenografts in nude rats from human GBMs. However, implementing tumour models based on primary tissue requires that these models can be sufficiently standardised with consistently high take rates. Methods In this work, we collected data on growth kinetics from a material of 29 biopsies xenografted in nude rats, and characterised this model with an emphasis on neuropathological and radiological features. Results The tumour take rate for xenografted GBM biopsies were 96% and remained close to 100% at subsequent passages in vivo, whereas only one of four lower grade tumours engrafted. Average time from transplantation to the onset of symptoms was 125 days ± 11.5 SEM. Histologically, the primary xenografts recapitulated the invasive features of the parent tumours while endothelial cell proliferations and necrosis were mostly absent. After 4-5 in vivo passages, the tumours became more vascular with necrotic areas, but also appeared more circumscribed. MRI typically revealed changes related to tumour growth, several months prior to the onset of symptoms. Conclusions In vivo passaging of patient GBM biopsies produced tumours representative of the patient tumours, with high take rates and a reproducible disease course. The model provides combinations of angiogenic and invasive phenotypes and represents a good alternative to in vitro propagated cell lines for dissecting mechanisms of brain tumour progression.

  19. Establishment of reproducible osteosarcoma rat model using orthotopic implantation technique.

    Science.gov (United States)

    Yu, Zhe; Sun, Honghui; Fan, Qingyu; Long, Hua; Yang, Tongtao; Ma, Bao'an

    2009-05-01

    osteosarcoma model was shown to be feasible: the take rate was high, surgical mortality was negligible and the procedure was simple to perform and easily reproduced. It may be a useful tool in the investigation of antiangiogenic and anticancer therapeutics. Ultrasound was found to be a highly accurate tool for tumor diagnosis, localization and measurement and may be recommended for monitoring tumor growth in this model.

  20. Hydrological Modeling Reproducibility Through Data Management and Adaptors for Model Interoperability

    Science.gov (United States)

    Turner, M. A.

    2015-12-01

    Because of a lack of centralized planning and no widely-adopted standards among hydrological modeling research groups, research communities, and the data management teams meant to support research, there is chaos when it comes to data formats, spatio-temporal resolutions, ontologies, and data availability. All this makes true scientific reproducibility and collaborative integrated modeling impossible without some glue to piece it all together. Our Virtual Watershed Integrated Modeling System provides the tools and modeling framework hydrologists need to accelerate and fortify new scientific investigations by tracking provenance and providing adaptors for integrated, collaborative hydrologic modeling and data management. Under global warming trends where water resources are under increasing stress, reproducible hydrological modeling will be increasingly important to improve transparency and understanding of the scientific facts revealed through modeling. The Virtual Watershed Data Engine is capable of ingesting a wide variety of heterogeneous model inputs, outputs, model configurations, and metadata. We will demonstrate one example, starting from real-time raw weather station data packaged with station metadata. Our integrated modeling system will then create gridded input data via geostatistical methods along with error and uncertainty estimates. These gridded data are then used as input to hydrological models, all of which are available as web services wherever feasible. Models may be integrated in a data-centric way where the outputs too are tracked and used as inputs to "downstream" models. This work is part of an ongoing collaborative Tri-state (New Mexico, Nevada, Idaho) NSF EPSCoR Project, WC-WAVE, comprised of researchers from multiple universities in each of the three states. The tools produced and presented here have been developed collaboratively alongside watershed scientists to address specific modeling problems with an eye on the bigger picture of

  1. Reproducing Phenomenology of Peroxidation Kinetics via Model Optimization

    Science.gov (United States)

    Ruslanov, Anatole D.; Bashylau, Anton V.

    2010-06-01

    We studied mathematical modeling of lipid peroxidation using a biochemical model system of iron (II)-ascorbate-dependent lipid peroxidation of rat hepatocyte mitochondrial fractions. We found that antioxidants extracted from plants demonstrate a high intensity of peroxidation inhibition. We simplified the system of differential equations that describes the kinetics of the mathematical model to a first order equation, which can be solved analytically. Moreover, we endeavor to algorithmically and heuristically recreate the processes and construct an environment that closely resembles the corresponding natural system. Our results demonstrate that it is possible to theoretically predict both the kinetics of oxidation and the intensity of inhibition without resorting to analytical and biochemical research, which is important for cost-effective discovery and development of medical agents with antioxidant action from the medicinal plants.

  2. Using a 1-D model to reproduce diurnal SST signals

    DEFF Research Database (Denmark)

    Karagali, Ioanna; Høyer, Jacob L.

    2014-01-01

    of measurement. A generally preferred approach to bridge the gap between in situ and remotely obtained measurements is through modelling of the upper ocean temperature. This ESA supported study focuses on the implementation of the 1 dimensional General Ocean Turbulence Model (GOTM), in order to resolve...... an additional parametrisation for the total outgoing long-wave radiation and a 9-band parametrisation for the light extinction. New parametrisations for the stability functions, associated with vertical mixing, have been included. GOTM is tested using experimental data from the Woods Hole Oceanographic...

  3. Reproducible Infection Model for Clostridium perfringens in Broiler Chickens

    DEFF Research Database (Denmark)

    Pedersen, Karl; Friis-Holm, Lotte Bjerrum; Heuer, Ole Eske

    2008-01-01

    Experiments were carried out to establish an infection and disease model for Clostridium perfringens in broiler chickens. Previous experiments had failed to induce disease and only a transient colonization with challenge strains had been obtained. In the present study, two series of experiments...

  4. COMBINE archive and OMEX format : One file to share all information to reproduce a modeling project

    NARCIS (Netherlands)

    Bergmann, Frank T.; Olivier, Brett G.; Soiland-Reyes, Stian

    2014-01-01

    Background: With the ever increasing use of computational models in the biosciences, the need to share models and reproduce the results of published studies efficiently and easily is becoming more important. To this end, various standards have been proposed that can be used to describe models,

  5. Investigation of dimensional variation in parts manufactured by fused deposition modeling using Gauge Repeatability and Reproducibility

    Science.gov (United States)

    Mohamed, Omar Ahmed; Hasan Masood, Syed; Lal Bhowmik, Jahar

    2018-02-01

    In the additive manufacturing (AM) market, the question is raised by industry and AM users on how reproducible and repeatable the fused deposition modeling (FDM) process is in providing good dimensional accuracy. This paper aims to investigate and evaluate the repeatability and reproducibility of the FDM process through a systematic approach to answer this frequently asked question. A case study based on the statistical gage repeatability and reproducibility (gage R&R) technique is proposed to investigate the dimensional variations in the printed parts of the FDM process. After running the simulation and analysis of the data, the FDM process capability is evaluated, which would help the industry for better understanding the performance of FDM technology.

  6. Using the mouse to model human disease: increasing validity and reproducibility

    Directory of Open Access Journals (Sweden)

    Monica J. Justice

    2016-02-01

    Full Text Available Experiments that use the mouse as a model for disease have recently come under scrutiny because of the repeated failure of data, particularly derived from preclinical studies, to be replicated or translated to humans. The usefulness of mouse models has been questioned because of irreproducibility and poor recapitulation of human conditions. Newer studies, however, point to bias in reporting results and improper data analysis as key factors that limit reproducibility and validity of preclinical mouse research. Inaccurate and incomplete descriptions of experimental conditions also contribute. Here, we provide guidance on best practice in mouse experimentation, focusing on appropriate selection and validation of the model, sources of variation and their influence on phenotypic outcomes, minimum requirements for control sets, and the importance of rigorous statistics. Our goal is to raise the standards in mouse disease modeling to enhance reproducibility, reliability and clinical translation of findings.

  7. Reproducibility of the coil positioning in Nb$_3$Sn magnet models through magnetic measurements

    CERN Document Server

    Borgnolutti, F; Ferracin, P; Kashikhin, V V; Sabbi, G; Velev, G; Todesco, E; Zlobin, A V

    2009-01-01

    The random part of the integral field harmonics in a series of superconducting magnets has been used in the past to identify the reproducibility of the coil positioning. Using a magnetic model and a MonteCarlo approach, coil blocks are randomly moved and the amplitude that best fits the magnetic measurements is interpreted as the reproducibility of the coil position. Previous values for r.m.s. coil displacements for Nb-Ti magnets range from 0.05 to 0.01 mm. In this paper, we use this approach to estimate the reproducibility in the coil position for Nb3Sn short models that have been built in the framework of the FNAL core program (HFDA dipoles) and of the LARP program (TQ quadrupoles). Our analysis shows that the Nb3Sn models manufactured in the past years correspond to r.m.s. coil displacements of at least 5 times what is found for the series production of a mature Nb-Ti technology. On the other hand, the variability of the field harmonics along the magnet axis shows that Nb3Sn magnets have already reached va...

  8. Aging Successfully: A Four-Factor Model

    Science.gov (United States)

    Lee, Pai-Lin; Lan, William; Yen, Tung-Wen

    2011-01-01

    The study was designed to validate a model for a successful aging process and examine the gender differences in the aging process. Three hundred twelve participants who were 65 or older completed a Taiwan Social Change Survey that measures four factors that define successful aging process: including physical, psychological, social support, and…

  9. Cellular automaton model in the fundamental diagram approach reproducing the synchronized outflow of wide moving jams

    International Nuclear Information System (INIS)

    Tian, Jun-fang; Yuan, Zhen-zhou; Jia, Bin; Fan, Hong-qiang; Wang, Tao

    2012-01-01

    Velocity effect and critical velocity are incorporated into the average space gap cellular automaton model [J.F. Tian, et al., Phys. A 391 (2012) 3129], which was able to reproduce many spatiotemporal dynamics reported by the three-phase theory except the synchronized outflow of wide moving jams. The physics of traffic breakdown has been explained. Various congested patterns induced by the on-ramp are reproduced. It is shown that the occurrence of synchronized outflow, free outflow of wide moving jams is closely related with drivers time delay in acceleration at the downstream jam front and the critical velocity, respectively. -- Highlights: ► Velocity effect is added into average space gap cellular automaton model. ► The physics of traffic breakdown has been explained. ► The probabilistic nature of traffic breakdown is simulated. ► Various congested patterns induced by the on-ramp are reproduced. ► The occurrence of synchronized outflow of jams depends on drivers time delay.

  10. MODEL OF TRAINING OF SUCCESS IN LIFE

    Directory of Open Access Journals (Sweden)

    Екатерина Александровна Лежнева

    2014-04-01

    Full Text Available The article explains the importance of the development of motive to succeed in adolescence. It is determined the value of the motive to achieve success in the further development of the teenager: a motive to achieve effective internal forces mobilized for the implementation of successful operation ensures the active involvement of teenagers in social and interpersonal relationships. As the primary means of motive development success is considered training. The author provides a definition of "training for success in life," creates a model of training for success in life, and describes its units (targeted, informative, technological, productive, reveals the successful development of the technology life strategy used during the training (self-presentation, targets, incentives, subject-orientation. The author pays attention to the need for a future psychologist to develop teenagers’ motive to achieve success through the mastery of competence in constructing a model of training for success in life, and its implementation in the course of professional activities. The main means of training students of psychology to the use of training success in life identified the additional educational programs and psychological section.DOI: http://dx.doi.org/10.12731/2218-7405-2013-9-77

  11. NRFixer: Sentiment Based Model for Predicting the Fixability of Non-Reproducible Bugs

    Directory of Open Access Journals (Sweden)

    Anjali Goyal

    2017-08-01

    Full Text Available Software maintenance is an essential step in software development life cycle. Nowadays, software companies spend approximately 45\\% of total cost in maintenance activities. Large software projects maintain bug repositories to collect, organize and resolve bug reports. Sometimes it is difficult to reproduce the reported bug with the information present in a bug report and thus this bug is marked with resolution non-reproducible (NR. When NR bugs are reconsidered, a few of them might get fixed (NR-to-fix leaving the others with the same resolution (NR. To analyse the behaviour of developers towards NR-to-fix and NR bugs, the sentiment analysis of NR bug report textual contents has been conducted. The sentiment analysis of bug reports shows that NR bugs' sentiments incline towards more negativity than reproducible bugs. Also, there is a noticeable opinion drift found in the sentiments of NR-to-fix bug reports. Observations driven from this analysis were an inspiration to develop a model that can judge the fixability of NR bugs. Thus a framework, {NRFixer,} which predicts the probability of NR bug fixation, is proposed. {NRFixer} was evaluated with two dimensions. The first dimension considers meta-fields of bug reports (model-1 and the other dimension additionally incorporates the sentiments (model-2 of developers for prediction. Both models were compared using various machine learning classifiers (Zero-R, naive Bayes, J48, random tree and random forest. The bug reports of Firefox and Eclipse projects were used to test {NRFixer}. In Firefox and Eclipse projects, J48 and Naive Bayes classifiers achieve the best prediction accuracy, respectively. It was observed that the inclusion of sentiments in the prediction model shows a rise in the prediction accuracy ranging from 2 to 5\\% for various classifiers.

  12. Reproducing Sea-Ice Deformation Distributions With Viscous-Plastic Sea-Ice Models

    Science.gov (United States)

    Bouchat, A.; Tremblay, B.

    2016-02-01

    High resolution sea-ice dynamic models offer the potential to discriminate between sea-ice rheologies based on their ability to reproduce the satellite-derived deformation fields. Recent studies have shown that sea-ice viscous-plastic (VP) models do not reproduce the observed statistical properties of the strain rate distributions of the RADARSAT Geophysical Processor System (RGPS) deformation fields [1][2]. We use the elliptical VP rheology and we compute the probability density functions (PDFs) for simulated strain rate invariants (divergence and maximum shear stress) and compare against the deformations obtained with the 3-day gridded products from RGPS. We find that the large shear deformations are well reproduced by the elliptical VP model and the deformations do not follow a Gaussian distribution as reported in Girard et al. [1][2]. On the other hand, we do find an overestimation of the shear in the range of mid-magnitude deformations in all of our VP simulations tested with different spatial resolutions and numerical parameters. Runs with no internal stress (free-drift) or with constant viscosity coefficients (Newtonian fluid) also show this overestimation. We trace back this discrepancy to the elliptical yield curve aspect ratio (e = 2) having too little shear strength, hence not resisting enough the inherent shear in the wind forcing associated with synoptic weather systems. Experiments where we simply increase the shear resistance of the ice by modifying the ellipse ratio confirm the need for a rheology with an increased shear strength. [1] Girard et al. (2009), Evaluation of high-resolution sea ice models [...], Journal of Geophysical Research, 114[2] Girard et al. (2011), A new modeling framework for sea-ice mechanics [...], Annals of Glaciology, 57, 123-132

  13. Evaluation of fecal mRNA reproducibility via a marginal transformed mixture modeling approach

    Directory of Open Access Journals (Sweden)

    Davidson Laurie A

    2010-01-01

    Full Text Available Abstract Background Developing and evaluating new technology that enables researchers to recover gene-expression levels of colonic cells from fecal samples could be key to a non-invasive screening tool for early detection of colon cancer. The current study, to the best of our knowledge, is the first to investigate and report the reproducibility of fecal microarray data. Using the intraclass correlation coefficient (ICC as a measure of reproducibility and the preliminary analysis of fecal and mucosal data, we assessed the reliability of mixture density estimation and the reproducibility of fecal microarray data. Using Monte Carlo-based methods, we explored whether ICC values should be modeled as a beta-mixture or transformed first and fitted with a normal-mixture. We used outcomes from bootstrapped goodness-of-fit tests to determine which approach is less sensitive toward potential violation of distributional assumptions. Results The graphical examination of both the distributions of ICC and probit-transformed ICC (PT-ICC clearly shows that there are two components in the distributions. For ICC measurements, which are between 0 and 1, the practice in literature has been to assume that the data points are from a beta-mixture distribution. Nevertheless, in our study we show that the use of a normal-mixture modeling approach on PT-ICC could provide superior performance. Conclusions When modeling ICC values of gene expression levels, using mixture of normals in the probit-transformed (PT scale is less sensitive toward model mis-specification than using mixture of betas. We show that a biased conclusion could be made if we follow the traditional approach and model the two sets of ICC values using the mixture of betas directly. The problematic estimation arises from the sensitivity of beta-mixtures toward model mis-specification, particularly when there are observations in the neighborhood of the the boundary points, 0 or 1. Since beta-mixture modeling

  14. Reproducing the optical properties of fine desert dust aerosols using ensembles of simple model particles

    International Nuclear Information System (INIS)

    Kahnert, Michael

    2004-01-01

    Single scattering optical properties are calculated for a proxy of fine dust aerosols at a wavelength of 0.55 μm. Spherical and spheroidal model particles are employed to fit the aerosol optical properties and to retrieve information about the physical parameters characterising the aerosols. It is found that spherical particles are capable of reproducing the scalar optical properties and the forward peak of the phase function of the dust aerosols. The effective size parameter of the aerosol ensemble is retrieved with high accuracy by using spherical model particles. Significant improvements are achieved by using spheroidal model particles. The aerosol phase function and the other diagonal elements of the Stokes scattering matrix can be fitted with high accuracy, whereas the off-diagonal elements are poorly reproduced. More elongated prolate and more flattened oblate spheroids contribute disproportionately strongly to the optimised shape distribution of the model particles and appear to be particularly useful for achieving a good fit of the scattering matrix. However, the clear discrepancies between the shape distribution of the aerosols and the shape distribution of the spheroidal model particles suggest that the possibilities of extracting shape information from optical observations are rather limited

  15. FUZZY MODELING BY SUCCESSIVE ESTIMATION OF RULES ...

    African Journals Online (AJOL)

    This paper presents an algorithm for automatically deriving fuzzy rules directly from a set of input-output data of a process for the purpose of modeling. The rules are extracted by a method termed successive estimation. This method is used to generate a model without truncating the number of fired rules, to within user ...

  16. A novel highly reproducible and lethal nonhuman primate model for orthopox virus infection.

    Directory of Open Access Journals (Sweden)

    Marit Kramski

    Full Text Available The intentional re-introduction of Variola virus (VARV, the agent of smallpox, into the human population is of great concern due its bio-terroristic potential. Moreover, zoonotic infections with Cowpox (CPXV and Monkeypox virus (MPXV cause severe diseases in humans. Smallpox vaccines presently available can have severe adverse effects that are no longer acceptable. The efficacy and safety of new vaccines and antiviral drugs for use in humans can only be demonstrated in animal models. The existing nonhuman primate models, using VARV and MPXV, need very high viral doses that have to be applied intravenously or intratracheally to induce a lethal infection in macaques. To overcome these drawbacks, the infectivity and pathogenicity of a particular CPXV was evaluated in the common marmoset (Callithrix jacchus.A CPXV named calpox virus was isolated from a lethal orthopox virus (OPV outbreak in New World monkeys. We demonstrated that marmosets infected with calpox virus, not only via the intravenous but also the intranasal route, reproducibly develop symptoms resembling smallpox in humans. Infected animals died within 1-3 days after onset of symptoms, even when very low infectious viral doses of 5x10(2 pfu were applied intranasally. Infectious virus was demonstrated in blood, saliva and all organs analyzed.We present the first characterization of a new OPV infection model inducing a disease in common marmosets comparable to smallpox in humans. Intranasal virus inoculation mimicking the natural route of smallpox infection led to reproducible infection. In vivo titration resulted in an MID(50 (minimal monkey infectious dose 50% of 8.3x10(2 pfu of calpox virus which is approximately 10,000-fold lower than MPXV and VARV doses applied in the macaque models. Therefore, the calpox virus/marmoset model is a suitable nonhuman primate model for the validation of vaccines and antiviral drugs. Furthermore, this model can help study mechanisms of OPV pathogenesis.

  17. Reproducing tailing in breakthrough curves: Are statistical models equally representative and predictive?

    Science.gov (United States)

    Pedretti, Daniele; Bianchi, Marco

    2018-03-01

    Breakthrough curves (BTCs) observed during tracer tests in highly heterogeneous aquifers display strong tailing. Power laws are popular models for both the empirical fitting of these curves, and the prediction of transport using upscaling models based on best-fitted estimated parameters (e.g. the power law slope or exponent). The predictive capacity of power law based upscaling models can be however questioned due to the difficulties to link model parameters with the aquifers' physical properties. This work analyzes two aspects that can limit the use of power laws as effective predictive tools: (a) the implication of statistical subsampling, which often renders power laws undistinguishable from other heavily tailed distributions, such as the logarithmic (LOG); (b) the difficulties to reconcile fitting parameters obtained from models with different formulations, such as the presence of a late-time cutoff in the power law model. Two rigorous and systematic stochastic analyses, one based on benchmark distributions and the other on BTCs obtained from transport simulations, are considered. It is found that a power law model without cutoff (PL) results in best-fitted exponents (αPL) falling in the range of typical experimental values reported in the literature (1.5 constant αCO ≈ 1. In the PLCO model, the cutoff rate (λ) is the parameter that fully reproduces the persistence of the tailing and is shown to be inversely correlated to the LOG scale parameter (i.e. with the skewness of the distribution). The theoretical results are consistent with the fitting analysis of a tracer test performed during the MADE-5 experiment. It is shown that a simple mechanistic upscaling model based on the PLCO formulation is able to predict the ensemble of BTCs from the stochastic transport simulations without the need of any fitted parameters. The model embeds the constant αCO = 1 and relies on a stratified description of the transport mechanisms to estimate λ. The PL fails to

  18. [Reproducibility and repeatability of the determination of occlusal plane on digital dental models].

    Science.gov (United States)

    Qin, Yi-fei; Xu, Tian-min

    2015-06-18

    To assess the repeatability(intraobserver comparison)and reproducibility(interobserver comparison)of two different methods for establishing the occlusal plane on digital dental models. With Angle's classification as a stratification factor,48 cases were randomly extracted from 806 ones which had integrated clinical data and had their orthodontic treatment from July 2004 to August 2008 in Department of Orthodontics ,Peking University School and Hospital of Stomatology.Post-treatment plaster casts of 48 cases were scanned by Roland LPX-1200 3D laser scanner to generate geometry data as research subjects.In a locally developed software package,one observer repeated 5 times at intervals of at least one week to localize prescriptive landmarks on each digital model to establish a group of functional occlusal planes and a group of anatomic occlusal planes, while 6 observers established two other groups of functional and anatomic occlusal planes independently.Standard deviations of dihedral angles of each group on each model were calculated and compared between the related groups.The models with the five largest standard deviations of each group were studied to explore possible factors that might influence the identification of the landmarks on the digital models. Significant difference of intraobserver variability was not detected between the functional occlusal plane and the anatomic occlusal plane (P>0.1), while that of interobserver variability was detected (Pocclusal plane was 0.2° smaller than that of the anatomic occlusal plane.The functional occlusal plane's variability of intraobserver and interobsever did not differ significantly (P>0.1), while the anatomic occlusal plane's variability of the intraobserver was significantly smaller than that of the interobserver (Pocclusal planes are suitable as a conference plane with equal repeatability. When several observers measure a large number of digital models,the functional occlusal plane is more reproducible than the

  19. Reproducibility, reliability and validity of measurements obtained from Cecile3 digital models

    Directory of Open Access Journals (Sweden)

    Gustavo Adolfo Watanabe-Kanno

    2009-09-01

    Full Text Available The aim of this study was to determine the reproducibility, reliability and validity of measurements in digital models compared to plaster models. Fifteen pairs of plaster models were obtained from orthodontic patients with permanent dentition before treatment. These were digitized to be evaluated with the program Cécile3 v2.554.2 beta. Two examiners measured three times the mesiodistal width of all the teeth present, intercanine, interpremolar and intermolar distances, overjet and overbite. The plaster models were measured using a digital vernier. The t-Student test for paired samples and interclass correlation coefficient (ICC were used for statistical analysis. The ICC of the digital models were 0.84 ± 0.15 (intra-examiner and 0.80 ± 0.19 (inter-examiner. The average mean difference of the digital models was 0.23 ± 0.14 and 0.24 ± 0.11 for each examiner, respectively. When the two types of measurements were compared, the values obtained from the digital models were lower than those obtained from the plaster models (p < 0.05, although the differences were considered clinically insignificant (differences < 0.1 mm. The Cécile digital models are a clinically acceptable alternative for use in Orthodontics.

  20. Reproducing the nonlinear dynamic behavior of a structured beam with a generalized continuum model

    Science.gov (United States)

    Vila, J.; Fernández-Sáez, J.; Zaera, R.

    2018-04-01

    In this paper we study the coupled axial-transverse nonlinear vibrations of a kind of one dimensional structured solids by application of the so called Inertia Gradient Nonlinear continuum model. To show the accuracy of this axiomatic model, previously proposed by the authors, its predictions are compared with numeric results from a previously defined finite discrete chain of lumped masses and springs, for several number of particles. A continualization of the discrete model equations based on Taylor series allowed us to set equivalent values of the mechanical properties in both discrete and axiomatic continuum models. Contrary to the classical continuum model, the inertia gradient nonlinear continuum model used herein is able to capture scale effects, which arise for modes in which the wavelength is comparable to the characteristic distance of the structured solid. The main conclusion of the work is that the proposed generalized continuum model captures the scale effects in both linear and nonlinear regimes, reproducing the behavior of the 1D nonlinear discrete model adequately.

  1. Assessment of the reliability of reproducing two-dimensional resistivity models using an image processing technique.

    Science.gov (United States)

    Ishola, Kehinde S; Nawawi, Mohd Nm; Abdullah, Khiruddin; Sabri, Ali Idriss Aboubakar; Adiat, Kola Abdulnafiu

    2014-01-01

    This study attempts to combine the results of geophysical images obtained from three commonly used electrode configurations using an image processing technique in order to assess their capabilities to reproduce two-dimensional (2-D) resistivity models. All the inverse resistivity models were processed using the PCI Geomatica software package commonly used for remote sensing data sets. Preprocessing of the 2-D inverse models was carried out to facilitate further processing and statistical analyses. Four Raster layers were created, three of these layers were used for the input images and the fourth layer was used as the output of the combined images. The data sets were merged using basic statistical approach. Interpreted results show that all images resolved and reconstructed the essential features of the models. An assessment of the accuracy of the images for the four geologic models was performed using four criteria: the mean absolute error and mean percentage absolute error, resistivity values of the reconstructed blocks and their displacements from the true models. Generally, the blocks of the images of maximum approach give the least estimated errors. Also, the displacement of the reconstructed blocks from the true blocks is the least and the reconstructed resistivities of the blocks are closer to the true blocks than any other combined used. Thus, it is corroborated that when inverse resistivity models are combined, most reliable and detailed information about the geologic models is obtained than using individual data sets.

  2. The substorm loading-unloading cycle as reproduced by community-available global MHD magnetospheric models

    Science.gov (United States)

    Gordeev, Evgeny; Sergeev, Victor; Tsyganenko, Nikolay; Kuznetsova, Maria; Rastaetter, Lutz; Raeder, Joachim; Toth, Gabor; Lyon, John; Merkin, Vyacheslav; Wiltberger, Michael

    2017-04-01

    In this study we investigate how well the three community-available global MHD models, supported by the Community Coordinated Modeling Center (CCMC NASA), reproduce the global magnetospheric dynamics, including the loading-unloading substorm cycle. We found that in terms of global magnetic flux transport CCMC models display systematically different response to idealized 2-hour north then 2-hour south IMF Bz variation. The LFM model shows a depressed return convection in the tail plasma sheet and high rate of magnetic flux loading into the lobes during the growth phase, as well as enhanced return convection and high unloading rate during the expansion phase, with the amount of loaded/unloaded magnetotail flux and the growth phase duration being the closest to their observed empirical values during isolated substorms. BATSRUS and Open GGCM models exhibit drastically different behavior. In the BATS-R-US model the plasma sheet convection shows a smooth transition to the steady convection regime after the IMF southward turning. In the Open GGCM a weak plasma sheet convection has comparable intensities during both the growth phase and the following slow unloading phase. Our study shows that different CCMC models under the same solar wind conditions (north to south IMF variation) produce essentially different solutions in terms of global magnetospheric convection.

  3. Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease

    Science.gov (United States)

    Machado, Mariana Verdelho; Michelotti, Gregory Alexander; Xie, Guanhua; de Almeida, Thiago Pereira; Boursier, Jerome; Bohnic, Brittany; Guy, Cynthia D.; Diehl, Anna Mae

    2015-01-01

    Background and aims Non-alcoholic steatohepatitis (NASH), the potentially progressive form of nonalcoholic fatty liver disease (NAFLD), is the pandemic liver disease of our time. Although there are several animal models of NASH, consensus regarding the optimal model is lacking. We aimed to compare features of NASH in the two most widely-used mouse models: methionine-choline deficient (MCD) diet and Western diet. Methods Mice were fed standard chow, MCD diet for 8 weeks, or Western diet (45% energy from fat, predominantly saturated fat, with 0.2% cholesterol, plus drinking water supplemented with fructose and glucose) for 16 weeks. Liver pathology and metabolic profile were compared. Results The metabolic profile associated with human NASH was better mimicked by Western diet. Although hepatic steatosis (i.e., triglyceride accumulation) was also more severe, liver non-esterified fatty acid content was lower than in the MCD diet group. NASH was also less severe and less reproducible in the Western diet model, as evidenced by less liver cell death/apoptosis, inflammation, ductular reaction, and fibrosis. Various mechanisms implicated in human NASH pathogenesis/progression were also less robust in the Western diet model, including oxidative stress, ER stress, autophagy deregulation, and hedgehog pathway activation. Conclusion Feeding mice a Western diet models metabolic perturbations that are common in humans with mild NASH, whereas administration of a MCD diet better models the pathobiological mechanisms that cause human NAFLD to progress to advanced NASH. PMID:26017539

  4. Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease.

    Directory of Open Access Journals (Sweden)

    Mariana Verdelho Machado

    Full Text Available Non-alcoholic steatohepatitis (NASH, the potentially progressive form of nonalcoholic fatty liver disease (NAFLD, is the pandemic liver disease of our time. Although there are several animal models of NASH, consensus regarding the optimal model is lacking. We aimed to compare features of NASH in the two most widely-used mouse models: methionine-choline deficient (MCD diet and Western diet.Mice were fed standard chow, MCD diet for 8 weeks, or Western diet (45% energy from fat, predominantly saturated fat, with 0.2% cholesterol, plus drinking water supplemented with fructose and glucose for 16 weeks. Liver pathology and metabolic profile were compared.The metabolic profile associated with human NASH was better mimicked by Western diet. Although hepatic steatosis (i.e., triglyceride accumulation was also more severe, liver non-esterified fatty acid content was lower than in the MCD diet group. NASH was also less severe and less reproducible in the Western diet model, as evidenced by less liver cell death/apoptosis, inflammation, ductular reaction, and fibrosis. Various mechanisms implicated in human NASH pathogenesis/progression were also less robust in the Western diet model, including oxidative stress, ER stress, autophagy deregulation, and hedgehog pathway activation.Feeding mice a Western diet models metabolic perturbations that are common in humans with mild NASH, whereas administration of a MCD diet better models the pathobiological mechanisms that cause human NAFLD to progress to advanced NASH.

  5. Mathematical Modeling Projects: Success for All Students

    Science.gov (United States)

    Shelton, Therese

    2018-01-01

    Mathematical modeling allows flexibility for a project-based experience. We share details of our regular capstone course, successful for virtually 100% of our math majors for almost two decades. Our research-like approach in this course accommodates a variety of student backgrounds and interests, and has produced some award-winning student…

  6. Circuit modeling of the electrical impedance: II. Normal subjects and system reproducibility

    International Nuclear Information System (INIS)

    Shiffman, C A; Rutkove, S B

    2013-01-01

    Part I of this series showed that the five-element circuit model accurately mimics impedances measured using multi-frequency electrical impedance myography (MFEIM), focusing on changes brought on by disease. This paper addresses two requirements which must be met if the method is to qualify for clinical use. First, the extracted parameters must be reproducible over long time periods such as those involved in the treatment of muscular disease, and second, differences amongst normal subjects should be attributable to known differences in the properties of healthy muscle. It applies the method to five muscle groups in 62 healthy subjects, closely following the procedure used earlier for the diseased subjects. Test–retest comparisons show that parameters are reproducible at levels from 6 to 16% (depending on the parameter) over time spans of up to 267 days, levels far below the changes occurring in serious disease. Also, variations with age, gender and muscle location are found to be consistent with established expectations for healthy muscle tissue. We conclude that the combination of MFEIM measurements and five-element circuit analysis genuinely reflects properties of muscle and is reliable enough to recommend its use in following neuromuscular disease. (paper)

  7. Reproducibility analysis of measurements with a mechanical semiautomatic eye model for evaluation of intraocular lenses

    Science.gov (United States)

    Rank, Elisabet; Traxler, Lukas; Bayer, Natascha; Reutterer, Bernd; Lux, Kirsten; Drauschke, Andreas

    2014-03-01

    Mechanical eye models are used to validate ex vivo the optical quality of intraocular lenses (IOLs). The quality measurement and test instructions for IOLs are defined in the ISO 11979-2. However, it was mentioned in literature that these test instructions could lead to inaccurate measurements in case of some modern IOL designs. Reproducibility of alignment and measurement processes are presented, performed with a semiautomatic mechanical ex vivo eye model based on optical properties published by Liou and Brennan in the scale 1:1. The cornea, the iris aperture and the IOL itself are separately changeable within the eye model. The adjustment of the IOL can be manipulated by automatic decentration and tilt of the IOL in reference to the optical axis of the whole system, which is defined by the connection line of the central point of the artificial cornea and the iris aperture. With the presented measurement setup two quality criteria are measurable: the modulation transfer function (MTF) and the Strehl ratio. First the reproducibility of the alignment process for definition of initial conditions of the lateral position and tilt in reference to the optical axis of the system is investigated. Furthermore, different IOL holders are tested related to the stable holding of the IOL. The measurement is performed by a before-after comparison of the lens position using a typical decentration and tilt tolerance analysis path. Modulation transfer function MTF and Strehl ratio S before and after this tolerance analysis are compared and requirements for lens holder construction are deduced from the presented results.

  8. Assessment of a climate model to reproduce rainfall variability and extremes over Southern Africa

    Science.gov (United States)

    Williams, C. J. R.; Kniveton, D. R.; Layberry, R.

    2010-01-01

    It is increasingly accepted that any possible climate change will not only have an influence on mean climate but may also significantly alter climatic variability. A change in the distribution and magnitude of extreme rainfall events (associated with changing variability), such as droughts or flooding, may have a far greater impact on human and natural systems than a changing mean. This issue is of particular importance for environmentally vulnerable regions such as southern Africa. The sub-continent is considered especially vulnerable to and ill-equipped (in terms of adaptation) for extreme events, due to a number of factors including extensive poverty, famine, disease and political instability. Rainfall variability and the identification of rainfall extremes is a function of scale, so high spatial and temporal resolution data are preferred to identify extreme events and accurately predict future variability. The majority of previous climate model verification studies have compared model output with observational data at monthly timescales. In this research, the assessment of ability of a state of the art climate model to simulate climate at daily timescales is carried out using satellite-derived rainfall data from the Microwave Infrared Rainfall Algorithm (MIRA). This dataset covers the period from 1993 to 2002 and the whole of southern Africa at a spatial resolution of 0.1° longitude/latitude. This paper concentrates primarily on the ability of the model to simulate the spatial and temporal patterns of present-day rainfall variability over southern Africa and is not intended to discuss possible future changes in climate as these have been documented elsewhere. Simulations of current climate from the UK Meteorological Office Hadley Centre's climate model, in both regional and global mode, are firstly compared to the MIRA dataset at daily timescales. Secondly, the ability of the model to reproduce daily rainfall extremes is assessed, again by a comparison with

  9. Why are models unable to reproduce multi-decadal trends in lower tropospheric baseline ozone levels?

    Science.gov (United States)

    Hu, L.; Liu, J.; Mickley, L. J.; Strahan, S. E.; Steenrod, S.

    2017-12-01

    Assessments of tropospheric ozone radiative forcing rely on accurate model simulations. Parrish et al (2014) found that three chemistry-climate models (CCMs) overestimate present-day O3 mixing ratios and capture only 50% of the observed O3 increase over the last five decades at 12 baseline sites in the northern mid-latitudes, indicating large uncertainties in our understanding of the ozone trends and their implications for radiative forcing. Here we present comparisons of outputs from two chemical transport models (CTMs) - GEOS-Chem and the Global Modeling Initiative model - with O3 observations from the same sites and from the global ozonesonde network. Both CTMs are driven by reanalysis meteorological data (MERRA or MERRA2) and thus are expected to be different in atmospheric transport processes relative to those freely running CCMs. We test whether recent model developments leading to more active ozone chemistry affect the computed ozone sensitivity to perturbations in emissions. Preliminary results suggest these CTMs can reproduce present-day ozone levels but fail to capture the multi-decadal trend since 1980. Both models yield widespread overpredictions of free tropospheric ozone in the 1980s. Sensitivity studies in GEOS-Chem suggest that the model estimate of natural background ozone is too high. We discuss factors that contribute to the variability and trends of tropospheric ozone over the last 30 years, with a focus on intermodel differences in spatial resolution and in the representation of stratospheric chemistry, stratosphere-troposphere exchange, halogen chemistry, and biogenic VOC emissions and chemistry. We also discuss uncertainty in the historical emission inventories used in models, and how these affect the simulated ozone trends.

  10. A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells.

    Directory of Open Access Journals (Sweden)

    Romeo Cecchelli

    Full Text Available The human blood brain barrier (BBB is a selective barrier formed by human brain endothelial cells (hBECs, which is important to ensure adequate neuronal function and protect the central nervous system (CNS from disease. The development of human in vitro BBB models is thus of utmost importance for drug discovery programs related to CNS diseases. Here, we describe a method to generate a human BBB model using cord blood-derived hematopoietic stem cells. The cells were initially differentiated into ECs followed by the induction of BBB properties by co-culture with pericytes. The brain-like endothelial cells (BLECs express tight junctions and transporters typically observed in brain endothelium and maintain expression of most in vivo BBB properties for at least 20 days. The model is very reproducible since it can be generated from stem cells isolated from different donors and in different laboratories, and could be used to predict CNS distribution of compounds in human. Finally, we provide evidence that Wnt/β-catenin signaling pathway mediates in part the BBB inductive properties of pericytes.

  11. Stochastic model of financial markets reproducing scaling and memory in volatility return intervals

    Science.gov (United States)

    Gontis, V.; Havlin, S.; Kononovicius, A.; Podobnik, B.; Stanley, H. E.

    2016-11-01

    We investigate the volatility return intervals in the NYSE and FOREX markets. We explain previous empirical findings using a model based on the interacting agent hypothesis instead of the widely-used efficient market hypothesis. We derive macroscopic equations based on the microscopic herding interactions of agents and find that they are able to reproduce various stylized facts of different markets and different assets with the same set of model parameters. We show that the power-law properties and the scaling of return intervals and other financial variables have a similar origin and could be a result of a general class of non-linear stochastic differential equations derived from a master equation of an agent system that is coupled by herding interactions. Specifically, we find that this approach enables us to recover the volatility return interval statistics as well as volatility probability and spectral densities for the NYSE and FOREX markets, for different assets, and for different time-scales. We find also that the historical S&P500 monthly series exhibits the same volatility return interval properties recovered by our proposed model. Our statistical results suggest that human herding is so strong that it persists even when other evolving fluctuations perturbate the financial system.

  12. How well do CMIP5 Climate Models Reproduce the Hydrologic Cycle of the Colorado River Basin?

    Science.gov (United States)

    Gautam, J.; Mascaro, G.

    2017-12-01

    The Colorado River, which is the primary source of water for nearly 40 million people in the arid Southwestern states of the United States, has been experiencing an extended drought since 2000, which has led to a significant reduction in water supply. As the water demands increase, one of the major challenges for water management in the region has been the quantification of uncertainties associated with streamflow predictions in the Colorado River Basin (CRB) under potential changes of future climate. Hence, testing the reliability of model predictions in the CRB is critical in addressing this challenge. In this study, we evaluated the performances of 17 General Circulation Models (GCMs) from the Coupled Model Intercomparison Project Phase Five (CMIP5) and 4 Regional Climate Models (RCMs) in reproducing the statistical properties of the hydrologic cycle in the CRB. We evaluated the water balance components at four nested sub-basins along with the inter-annual and intra-annual changes of precipitation (P), evaporation (E), runoff (R) and temperature (T) from 1979 to 2005. Most of the models captured the net water balance fairly well in the most-upstream basin but simulated a weak hydrological cycle in the evaporation channel at the downstream locations. The simulated monthly variability of P had different patterns, with correlation coefficients ranging from -0.6 to 0.8 depending on the sub-basin and the models from same parent institution clustering together. Apart from the most-upstream sub-basin where the models were mainly characterized by a negative seasonal bias in SON (of up to -50%), most of them had a positive bias in all seasons (of up to +260%) in the other three sub-basins. The models, however, captured the monthly variability of T well at all sites with small inter-model variabilities and a relatively similar range of bias (-7 °C to +5 °C) across all seasons. Mann-Kendall test was applied to the annual P and T time-series where majority of the models

  13. Synaptic augmentation in a cortical circuit model reproduces serial dependence in visual working memory.

    Directory of Open Access Journals (Sweden)

    Daniel P Bliss

    Full Text Available Recent work has established that visual working memory is subject to serial dependence: current information in memory blends with that from the recent past as a function of their similarity. This tuned temporal smoothing likely promotes the stability of memory in the face of noise and occlusion. Serial dependence accumulates over several seconds in memory and deteriorates with increased separation between trials. While this phenomenon has been extensively characterized in behavior, its neural mechanism is unknown. In the present study, we investigate the circuit-level origins of serial dependence in a biophysical model of cortex. We explore two distinct kinds of mechanisms: stable persistent activity during the memory delay period and dynamic "activity-silent" synaptic plasticity. We find that networks endowed with both strong reverberation to support persistent activity and dynamic synapses can closely reproduce behavioral serial dependence. Specifically, elevated activity drives synaptic augmentation, which biases activity on the subsequent trial, giving rise to a spatiotemporally tuned shift in the population response. Our hybrid neural model is a theoretical advance beyond abstract mathematical characterizations, offers testable hypotheses for physiological research, and demonstrates the power of biological insights to provide a quantitative explanation of human behavior.

  14. Fast bootstrapping and permutation testing for assessing reproducibility and interpretability of multivariate fMRI decoding models.

    Directory of Open Access Journals (Sweden)

    Bryan R Conroy

    Full Text Available Multivariate decoding models are increasingly being applied to functional magnetic imaging (fMRI data to interpret the distributed neural activity in the human brain. These models are typically formulated to optimize an objective function that maximizes decoding accuracy. For decoding models trained on full-brain data, this can result in multiple models that yield the same classification accuracy, though some may be more reproducible than others--i.e. small changes to the training set may result in very different voxels being selected. This issue of reproducibility can be partially controlled by regularizing the decoding model. Regularization, along with the cross-validation used to estimate decoding accuracy, typically requires retraining many (often on the order of thousands of related decoding models. In this paper we describe an approach that uses a combination of bootstrapping and permutation testing to construct both a measure of cross-validated prediction accuracy and model reproducibility of the learned brain maps. This requires re-training our classification method on many re-sampled versions of the fMRI data. Given the size of fMRI datasets, this is normally a time-consuming process. Our approach leverages an algorithm called fast simultaneous training of generalized linear models (FaSTGLZ to create a family of classifiers in the space of accuracy vs. reproducibility. The convex hull of this family of classifiers can be used to identify a subset of Pareto optimal classifiers, with a single-optimal classifier selectable based on the relative cost of accuracy vs. reproducibility. We demonstrate our approach using full-brain analysis of elastic-net classifiers trained to discriminate stimulus type in an auditory and visual oddball event-related fMRI design. Our approach and results argue for a computational approach to fMRI decoding models in which the value of the interpretation of the decoding model ultimately depends upon optimizing a

  15. Developing a Successful Open Source Training Model

    Directory of Open Access Journals (Sweden)

    Belinda Lopez

    2010-01-01

    Full Text Available Training programs for open source software provide a tangible, and sellable, product. A successful training program not only builds revenue, it also adds to the overall body of knowledge available for the open source project. By gathering best practices and taking advantage of the collective expertise within a community, it may be possible for a business to partner with an open source project to build a curriculum that promotes the project and supports the needs of the company's training customers. This article describes the initial approach used by Canonical, the commercial sponsor of the Ubuntu Linux operating system, to engage the community in the creation of its training offerings. We then discuss alternate curriculum creation models and some of the conditions that are necessary for successful collaboration between creators of existing documentation and commercial training providers.

  16. Rainfall variability and extremes over southern Africa: Assessment of a climate model to reproduce daily extremes

    Science.gov (United States)

    Williams, C. J. R.; Kniveton, D. R.; Layberry, R.

    2009-04-01

    It is increasingly accepted that that any possible climate change will not only have an influence on mean climate but may also significantly alter climatic variability. A change in the distribution and magnitude of extreme rainfall events (associated with changing variability), such as droughts or flooding, may have a far greater impact on human and natural systems than a changing mean. This issue is of particular importance for environmentally vulnerable regions such as southern Africa. The subcontinent is considered especially vulnerable to and ill-equipped (in terms of adaptation) for extreme events, due to a number of factors including extensive poverty, famine, disease and political instability. Rainfall variability and the identification of rainfall extremes is a function of scale, so high spatial and temporal resolution data are preferred to identify extreme events and accurately predict future variability. The majority of previous climate model verification studies have compared model output with observational data at monthly timescales. In this research, the assessment of ability of a state of the art climate model to simulate climate at daily timescales is carried out using satellite derived rainfall data from the Microwave Infra-Red Algorithm (MIRA). This dataset covers the period from 1993-2002 and the whole of southern Africa at a spatial resolution of 0.1 degree longitude/latitude. The ability of a climate model to simulate current climate provides some indication of how much confidence can be applied to its future predictions. In this paper, simulations of current climate from the UK Meteorological Office Hadley Centre's climate model, in both regional and global mode, are firstly compared to the MIRA dataset at daily timescales. This concentrates primarily on the ability of the model to simulate the spatial and temporal patterns of rainfall variability over southern Africa. Secondly, the ability of the model to reproduce daily rainfall extremes will

  17. Cross-species analysis of gene expression in non-model mammals: reproducibility of hybridization on high density oligonucleotide microarrays

    Directory of Open Access Journals (Sweden)

    Pita-Thomas Wolfgang

    2007-04-01

    Full Text Available Abstract Background Gene expression profiles of non-model mammals may provide valuable data for biomedical and evolutionary studies. However, due to lack of sequence information of other species, DNA microarrays are currently restricted to humans and a few model species. This limitation may be overcome by using arrays developed for a given species to analyse gene expression in a related one, an approach known as "cross-species analysis". In spite of its potential usefulness, the accuracy and reproducibility of the gene expression measures obtained in this way are still open to doubt. The present study examines whether or not hybridization values from cross-species analyses are as reproducible as those from same-species analyses when using Affymetrix oligonucleotide microarrays. Results The reproducibility of the probe data obtained hybridizing deer, Old-World primates, and human RNA samples to Affymetrix human GeneChip® U133 Plus 2.0 was compared. The results show that cross-species hybridization affected neither the distribution of the hybridization reproducibility among different categories, nor the reproducibility values of the individual probes. Our analyses also show that a 0.5% of the probes analysed in the U133 plus 2.0 GeneChip are significantly associated to un-reproducible hybridizations. Such probes-called in the text un-reproducible probe sequences- do not increase in number in cross-species analyses. Conclusion Our study demonstrates that cross-species analyses do not significantly affect hybridization reproducibility of GeneChips, at least within the range of the mammal species analysed here. The differences in reproducibility between same-species and cross-species analyses observed in previous studies were probably caused by the analytical methods used to calculate the gene expression measures. Together with previous observations on the accuracy of GeneChips for cross-species analysis, our analyses demonstrate that cross

  18. Model for a reproducible curriculum infrastructure to provide international nurse anesthesia continuing education.

    Science.gov (United States)

    Collins, Shawn Bryant

    2011-12-01

    There are no set standards for nurse anesthesia education in developing countries, yet one of the keys to the standards in global professional practice is competency assurance for individuals. Nurse anesthetists in developing countries have difficulty obtaining educational materials. These difficulties include, but are not limited to, financial constraints, lack of anesthesia textbooks, and distance from educational sites. There is increasing evidence that the application of knowledge in developing countries is failing. One reason is that many anesthetists in developing countries are trained for considerably less than acceptable time periods and are often supervised by poorly trained practitioners, who then pass on less-than-desirable practice skills, thus exacerbating difficulties. Sustainability of development can come only through anesthetists who are both well trained and able to pass on their training to others. The international nurse anesthesia continuing education project was developed in response to the difficulty that nurse anesthetists in developing countries face in accessing continuing education. The purpose of this project was to develop a nonprofit, volunteer-based model for providing nurse anesthesia continuing education that can be reproduced and used in any developing country.

  19. Composite model to reproduce the mechanical behaviour of methane hydrate bearing soils

    Science.gov (United States)

    De la Fuente, Maria

    2016-04-01

    Methane hydrate bearing sediments (MHBS) are naturally-occurring materials containing different components in the pores that may suffer phase changes under relative small temperature and pressure variations for conditions typically prevailing a few hundreds of meters below sea level. Their modelling needs to account for heat and mass balance equations of the different components, and several strategies already exist to combine them (e.g., Rutqvist & Moridis, 2009; Sánchez et al. 2014). These equations have to be completed by restrictions and constitutive laws reproducing the phenomenology of heat and fluid flows, phase change conditions and mechanical response. While the formulation of the non-mechanical laws generally includes explicitly the mass fraction of methane in each phase, which allows for a natural update of parameters during phase changes, mechanical laws are, in most cases, stated for the whole solid skeleton (Uchida et al., 2012; Soga et al. 2006). In this paper, a mechanical model is proposed to cope with the response of MHBS. It is based on a composite approach that allows defining the thermo-hydro-mechanical response of mineral skeleton and solid hydrates independently. The global stress-strain-temperature response of the solid phase (grains + hydrate) is then obtained by combining both responses according to energy principle following the work by Pinyol et al. (2007). In this way, dissociation of MH can be assessed on the basis of the stress state and temperature prevailing locally within the hydrate component. Besides, its structuring effect is naturally accounted for by the model according to patterns of MH inclusions within soil pores. This paper describes the fundamental hypothesis behind the model and its formulation. Its performance is assessed by comparison with laboratory data presented in the literature. An analysis of MHBS response to several stress-temperature paths representing potential field cases is finally presented. References

  20. A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease.

    Science.gov (United States)

    Beraldi, Rosanna; Chan, Chun-Hung; Rogers, Christopher S; Kovács, Attila D; Meyerholz, David K; Trantzas, Constantin; Lambertz, Allyn M; Darbro, Benjamin W; Weber, Krystal L; White, Katherine A M; Rheeden, Richard V; Kruer, Michael C; Dacken, Brian A; Wang, Xiao-Jun; Davis, Bryan T; Rohret, Judy A; Struzynski, Jason T; Rohret, Frank A; Weimer, Jill M; Pearce, David A

    2015-11-15

    Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. AT is a neurodegenerative disease primarily characterized by cerebellar degeneration in children leading to motor impairment. The disease progresses with other clinical manifestations including oculocutaneous telangiectasia, immune disorders, increased susceptibly to cancer and respiratory infections. Although genetic investigations and physiological models have established the linkage of ATM with AT onset, the mechanisms linking ATM to neurodegeneration remain undetermined, hindering therapeutic development. Several murine models of AT have been successfully generated showing some of the clinical manifestations of the disease, however they do not fully recapitulate the hallmark neurological phenotype, thus highlighting the need for a more suitable animal model. We engineered a novel porcine model of AT to better phenocopy the disease and bridge the gap between human and current animal models. The initial characterization of AT pigs revealed early cerebellar lesions including loss of Purkinje cells (PCs) and altered cytoarchitecture suggesting a developmental etiology for AT and could advocate for early therapies for AT patients. In addition, similar to patients, AT pigs show growth retardation and develop motor deficit phenotypes. By using the porcine system to model human AT, we established the first animal model showing PC loss and motor features of the human disease. The novel AT pig provides new opportunities to unmask functions and roles of ATM in AT disease and in physiological conditions. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  1. A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease

    Science.gov (United States)

    Beraldi, Rosanna; Chan, Chun-Hung; Rogers, Christopher S.; Kovács, Attila D.; Meyerholz, David K.; Trantzas, Constantin; Lambertz, Allyn M.; Darbro, Benjamin W.; Weber, Krystal L.; White, Katherine A.M.; Rheeden, Richard V.; Kruer, Michael C.; Dacken, Brian A.; Wang, Xiao-Jun; Davis, Bryan T.; Rohret, Judy A.; Struzynski, Jason T.; Rohret, Frank A.; Weimer, Jill M.; Pearce, David A.

    2015-01-01

    Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. AT is a neurodegenerative disease primarily characterized by cerebellar degeneration in children leading to motor impairment. The disease progresses with other clinical manifestations including oculocutaneous telangiectasia, immune disorders, increased susceptibly to cancer and respiratory infections. Although genetic investigations and physiological models have established the linkage of ATM with AT onset, the mechanisms linking ATM to neurodegeneration remain undetermined, hindering therapeutic development. Several murine models of AT have been successfully generated showing some of the clinical manifestations of the disease, however they do not fully recapitulate the hallmark neurological phenotype, thus highlighting the need for a more suitable animal model. We engineered a novel porcine model of AT to better phenocopy the disease and bridge the gap between human and current animal models. The initial characterization of AT pigs revealed early cerebellar lesions including loss of Purkinje cells (PCs) and altered cytoarchitecture suggesting a developmental etiology for AT and could advocate for early therapies for AT patients. In addition, similar to patients, AT pigs show growth retardation and develop motor deficit phenotypes. By using the porcine system to model human AT, we established the first animal model showing PC loss and motor features of the human disease. The novel AT pig provides new opportunities to unmask functions and roles of ATM in AT disease and in physiological conditions. PMID:26374845

  2. Can Computational Sediment Transport Models Reproduce the Observed Variability of Channel Networks in Modern Deltas?

    Science.gov (United States)

    Nesvold, E.; Mukerji, T.

    2017-12-01

    River deltas display complex channel networks that can be characterized through the framework of graph theory, as shown by Tejedor et al. (2015). Deltaic patterns may also be useful in a Bayesian approach to uncertainty quantification of the subsurface, but this requires a prior distribution of the networks of ancient deltas. By considering subaerial deltas, one can at least obtain a snapshot in time of the channel network spectrum across deltas. In this study, the directed graph structure is semi-automatically extracted from satellite imagery using techniques from statistical processing and machine learning. Once the network is labeled with vertices and edges, spatial trends and width and sinuosity distributions can also be found easily. Since imagery is inherently 2D, computational sediment transport models can serve as a link between 2D network structure and 3D depositional elements; the numerous empirical rules and parameters built into such models makes it necessary to validate the output with field data. For this purpose we have used a set of 110 modern deltas, with average water discharge ranging from 10 - 200,000 m3/s, as a benchmark for natural variability. Both graph theoretic and more general distributions are established. A key question is whether it is possible to reproduce this deltaic network spectrum with computational models. Delft3D was used to solve the shallow water equations coupled with sediment transport. The experimental setup was relatively simple; incoming channelized flow onto a tilted plane, with varying wave and tidal energy, sediment types and grain size distributions, river discharge and a few other input parameters. Each realization was run until a delta had fully developed: between 50 and 500 years (with a morphology acceleration factor). It is shown that input parameters should not be sampled independently from the natural ranges, since this may result in deltaic output that falls well outside the natural spectrum. Since we are

  3. Conceptual model suitability for reproducing preferential flow paths in waste rock piles

    Science.gov (United States)

    Broda, S.; Blessent, D.; Aubertin, M.

    2012-12-01

    Waste rocks are typically deposited on mining sites forming waste rock piles (WRP). Acid mine drainage (AMD) or contaminated neutral drainage (CND) with metal leaching from the sulphidic minerals adversely impact soil and water composition on and beyond the mining sites. The deposition method and the highly heterogeneous hydrogeological and geochemical properties of waste rock have a major impact on water and oxygen movement and pore water pressure distribution in the WRP, controlling AMD/CND production. However, the prediction and interpretation of water distribution in WRP is a challenging problem and many attempted numerical investigations of short and long term forecasts were found unreliable. Various forms of unsaturated localized preferential flow processes have been identified, for instance flow in macropores and fractures, heterogeneity-driven and gravity-driven unstable flow, with local hydraulic conductivities reaching several dozen meters per day. Such phenomena have been entirely neglected in numerical WRP modelling and are unattainable with the classical equivalent porous media conceptual approach typically used in this field. An additional complicating circumstance is the unknown location of macropores and fractures a priori. In this study, modeling techniques originally designed for massive fractured rock aquifers are applied. The properties of the waste rock material, found at the Tio mine at Havre Saint-Pierre, Québec (Canada), used in this modelling study were retrieved from laboratory permeability and water retention tests. These column tests were reproduced with the numerical 3D fully-integrated surface/subsurface flow model HydroGeoSphere, where material heterogeneity is represented by means of i) the dual continuum approach, ii) discrete fractures, and iii) a stochastic facies distribution framework using TPROGS. Comparisons with measured pore water pressures, tracer concentrations and exiting water volumes allowed defining limits and

  4. A novel, comprehensive, and reproducible porcine model for determining the timing of bruises in forensic pathology

    DEFF Research Database (Denmark)

    Barington, Kristiane; Jensen, Henrik Elvang

    2016-01-01

    in order to identify gross and histological parameters that may be useful in determining the age of a bruise. Methods The mechanical device was able to apply a single reproducible stroke with a plastic tube that was equivalent to being struck by a man. In each of 10 anesthetized pigs, four strokes...

  5. Pharmacokinetic Modelling to Predict FVIII:C Response to Desmopressin and Its Reproducibility in Nonsevere Haemophilia A Patients.

    Science.gov (United States)

    Schütte, Lisette M; van Hest, Reinier M; Stoof, Sara C M; Leebeek, Frank W G; Cnossen, Marjon H; Kruip, Marieke J H A; Mathôt, Ron A A

    2018-04-01

     Nonsevere haemophilia A (HA) patients can be treated with desmopressin. Response of factor VIII activity (FVIII:C) differs between patients and is difficult to predict.  Our aims were to describe FVIII:C response after desmopressin and its reproducibility by population pharmacokinetic (PK) modelling.  Retrospective data of 128 nonsevere HA patients (age 7-75 years) receiving an intravenous or intranasal dose of desmopressin were used. PK modelling of FVIII:C was performed by nonlinear mixed effect modelling. Reproducibility of FVIII:C response was defined as less than 25% difference in peak FVIII:C between administrations.  A total of 623 FVIII:C measurements from 142 desmopressin administrations were available; 14 patients had received two administrations at different occasions. The FVIII:C time profile was best described by a two-compartment model with first-order absorption and elimination. Interindividual variability of the estimated baseline FVIII:C, central volume of distribution and clearance were 37, 43 and 50%, respectively. The most recently measured FVIII:C (FVIII-recent) was significantly associated with FVIII:C response to desmopressin ( p  C increase of 0.47 IU/mL (median, interquartile range: 0.32-0.65 IU/mL, n  = 142). C response was reproducible in 6 out of 14 patients receiving two desmopressin administrations.  FVIII:C response to desmopressin in nonsevere HA patients was adequately described by a population PK model. Large variability in FVIII:C response was observed, which could only partially be explained by FVIII-recent. C response was not reproducible in a small subset of patients. Therefore, monitoring FVIII:C around surgeries or bleeding might be considered. Research is needed to study this further. Schattauer Stuttgart.

  6. FORMATIVE ASSESSMENT MODEL OF LEARNING SUCCESS ACHIEVEMENTS

    Directory of Open Access Journals (Sweden)

    Mikhailova Elena Konstantinovna

    2013-05-01

    Full Text Available The paper is devoted to the problem of assessment of the school students’ learning success achievements. The problem is investigated from the viewpoint of assessing the students’ learning outcomes that is aimed to ensure the teachers and students with the means and conditions to improve the educational process and results.

  7. The Personal Marketing Pyramid: A Model for Secretarial Success.

    Science.gov (United States)

    Caudill, Donald W.

    1988-01-01

    The author describes his model of a synergistic approach to achieving success. His Personal Marketing Pyramid consists of four sciences: physiology, psychology, sociology, and philosophy. He uses examples related to success in a secretarial career. (CH)

  8. Achieving Success in Measurement and Reliability Modeling

    OpenAIRE

    Keller, Ted; Munson, John C.; Schneidewind, Norman; Stark, George

    1993-01-01

    Panel Session at the International Symposium on Software Reliability Engineering 1993, Saturday: 6 November 1993, 0830-1000 and 1030-1200 The NASA Space Shuttle on-board software is one of the nation’s most safety-critical software systems. The process which produces this software has been rated at maturity level five. Among the quality assurance methods that are used to ensure the software is free of safetycritical faults is the use of reliability modelling and predi...

  9. Validation of EURO-CORDEX regional climate models in reproducing the variability of precipitation extremes in Romania

    Science.gov (United States)

    Dumitrescu, Alexandru; Busuioc, Aristita

    2016-04-01

    EURO-CORDEX is the European branch of the international CORDEX initiative that aims to provide improved regional climate change projections for Europe. The main objective of this paper is to document the performance of the individual models in reproducing the variability of precipitation extremes in Romania. Here three EURO-CORDEX regional climate models (RCMs) ensemble (scenario RCP4.5) are analysed and inter-compared: DMI-HIRHAM5, KNMI-RACMO2.2 and MPI-REMO. Compared to previous studies, when the RCM validation regarding the Romanian climate has mainly been made on mean state and at station scale, a more quantitative approach of precipitation extremes is proposed. In this respect, to have a more reliable comparison with observation, a high resolution daily precipitation gridded data set was used as observational reference (CLIMHYDEX project). The comparison between the RCM outputs and observed grid point values has been made by calculating three extremes precipitation indices, recommended by the Expert Team on Climate Change Detection Indices (ETCCDI), for the 1976-2005 period: R10MM, annual count of days when precipitation ≥10mm; RX5DAY, annual maximum 5-day precipitation and R95P%, precipitation fraction of annual total precipitation due to daily precipitation > 95th percentile. The RCMs capability to reproduce the mean state for these variables, as well as the main modes of their spatial variability (given by the first three EOF patterns), are analysed. The investigation confirms the ability of RCMs to simulate the main features of the precipitation extreme variability over Romania, but some deficiencies in reproducing of their regional characteristics were found (for example, overestimation of the mea state, especially over the extra Carpathian regions). This work has been realised within the research project "Changes in climate extremes and associated impact in hydrological events in Romania" (CLIMHYDEX), code PN II-ID-2011-2-0073, financed by the Romanian

  10. Using a 1-D model to reproduce the diurnal variability of SST

    DEFF Research Database (Denmark)

    Karagali, Ioanna; Høyer, Jacob L.; Donlon, Craig J.

    2017-01-01

    preferred approach to bridge the gap between in situ and remotely sensed measurements and obtain diurnal warming estimates at large spatial scales is modeling of the upper ocean temperature. This study uses the one-dimensional General Ocean Turbulence Model (GOTM) to resolve diurnal signals identified from...... forcing fields and is able to resolve daily SST variability seen both from satellite and in situ measurements. As such, and due to its low computational cost, it is proposed as a candidate model for diurnal variability estimates....

  11. Energy and nutrient deposition and excretion in the reproducing sow: model development and evaluation

    DEFF Research Database (Denmark)

    Hansen, A V; Strathe, A B; Theil, Peter Kappel

    2014-01-01

    was related to predictions of body fat and protein loss from the lactation model. Nitrogen intake, urine N, fecal N, and milk N were predicted with RMSPE as percentage of observed mean of 9.7, 17.9, 10.0, and 7.7%, respectively. The model provided a framework, but more refinements and improvements in accuracy......Air and nutrient emissions from swine operations raise environmental concerns. During the reproduction phase, sows consume and excrete large quantities of nutrients. The objective of this study was to develop a mathematical model to describe energy and nutrient partitioning and predict manure...... excretion and composition and methane emissions on a daily basis. The model was structured to contain gestation and lactation modules, which can be run separately or sequentially, with outputs from the gestation module used as inputs to the lactation module. In the gestating module, energy and protein...

  12. Do on/off time series models reproduce emerging stock market comovements?

    OpenAIRE

    Mohamed el hédi Arouri; Fredj Jawadi

    2011-01-01

    Using nonlinear modeling tools, this study investigates the comovements between the Mexican and the world stock markets over the last three decades. While the previous works only highlight some evidence of comovements, our paper aims to specify the different time-varying links and mechanisms characterizing the Mexican stock market through the comparison of two nonlinear error correction models (NECMs). Our findings point out strong evidence of time-varying and nonlinear mean-reversion and lin...

  13. The Computable Catchment: An executable document for model-data software sharing, reproducibility and interactive visualization

    Science.gov (United States)

    Gil, Y.; Duffy, C.

    2015-12-01

    This paper proposes the concept of a "Computable Catchment" which is used to develop a collaborative platform for watershed modeling and data analysis. The object of the research is a sharable, executable document similar to a pdf, but one that includes documentation of the underlying theoretical concepts, interactive computational/numerical resources, linkage to essential data repositories and the ability for interactive model-data visualization and analysis. The executable document for each catchment is stored in the cloud with automatic provisioning and a unique identifier allowing collaborative model and data enhancements for historical hydroclimatic reconstruction and/or future landuse or climate change scenarios to be easily reconstructed or extended. The Computable Catchment adopts metadata standards for naming all variables in the model and the data. The a-priori or initial data is derived from national data sources for soils, hydrogeology, climate, and land cover available from the www.hydroterre.psu.edu data service (Leonard and Duffy, 2015). The executable document is based on Wolfram CDF or Computable Document Format with an interactive open-source reader accessible by any modern computing platform. The CDF file and contents can be uploaded to a website or simply shared as a normal document maintaining all interactive features of the model and data. The Computable Catchment concept represents one application for Geoscience Papers of the Future representing an extensible document that combines theory, models, data and analysis that are digitally shared, documented and reused among research collaborators, students, educators and decision makers.

  14. Modelling the effect of food availability on recruitment success of ...

    African Journals Online (AJOL)

    The results show the importance of food (especially diatoms and copepods) dynamics on the spatial and temporal patterns of recruitment success, and also confirm the importance of the spawning area, timing and water depth on the recruitment success of Cape anchovy larvae. Keywords: 3-D modelling, IBM model, pelagic ...

  15. Model approach brings multi-level success.

    Science.gov (United States)

    Howell, Mark

    2012-08-01

    n an article that first appeared in US magazine, Medical Construction & Design, Mark Howell, senior vice-president of Skanska USA Building, based in Seattle, describes the design and construction of a new nine-storey, 350,000 ft2 extension to the Good Samaritan Hospital in Puyallup, Washington state. He explains how the use of an Integrated Project Delivery (IPD) approach by the key players, and extensive use of building information modelling (BIM), combined to deliver a healthcare facility that he believes should meet the needs of patients, families, and the clinical care team, 'well into the future'.

  16. Model of key success factors for Business Intelligence implementation

    Directory of Open Access Journals (Sweden)

    Peter Mesaros

    2016-07-01

    Full Text Available New progressive technologies recorded growth in every area. Information-communication technologies facilitate the exchange of information and it facilitates management of everyday activities in enterprises. Specific modules (such as Business Intelligence facilitate decision-making. Several studies have demonstrated the positive impact of Business Intelligence to decision-making. The first step is to put in place the enterprise. The implementation process is influenced by many factors. This article discusses the issue of key success factors affecting to successful implementation of Business Intelligence. The article describes the key success factors for successful implementation and use of Business Intelligence based on multiple studies. The main objective of this study is to verify the effects and dependence of selected factors and proposes a model of key success factors for successful implementation of Business Intelligence. Key success factors and the proposed model are studied in Slovak enterprises.

  17. "High-precision, reconstructed 3D model" of skull scanned by conebeam CT: Reproducibility verified using CAD/CAM data.

    Science.gov (United States)

    Katsumura, Seiko; Sato, Keita; Ikawa, Tomoko; Yamamura, Keiko; Ando, Eriko; Shigeta, Yuko; Ogawa, Takumi

    2016-01-01

    Computed tomography (CT) scanning has recently been introduced into forensic medicine and dentistry. However, the presence of metal restorations in the dentition can adversely affect the quality of three-dimensional reconstruction from CT scans. In this study, we aimed to evaluate the reproducibility of a "high-precision, reconstructed 3D model" obtained from a conebeam CT scan of dentition, a method that might be particularly helpful in forensic medicine. We took conebeam CT and helical CT images of three dry skulls marked with 47 measuring points; reconstructed three-dimensional images; and measured the distances between the points in the 3D images with a computer-aided design/computer-aided manufacturing (CAD/CAM) marker. We found that in comparison with the helical CT, conebeam CT is capable of reproducing measurements closer to those obtained from the actual samples. In conclusion, our study indicated that the image-reproduction from a conebeam CT scan was more accurate than that from a helical CT scan. Furthermore, the "high-precision reconstructed 3D model" facilitates reliable visualization of full-sized oral and maxillofacial regions in both helical and conebeam CT scans. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  18. A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease

    OpenAIRE

    Beraldi, Rosanna; Chan, Chun-Hung; Rogers, Christopher S.; Kovács, Attila D.; Meyerholz, David K.; Trantzas, Constantin; Lambertz, Allyn M.; Darbro, Benjamin W.; Weber, Krystal L.; White, Katherine A.M.; Rheeden, Richard V.; Kruer, Michael C.; Dacken, Brian A.; Wang, Xiao-Jun; Davis, Bryan T.

    2015-01-01

    Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. AT is a neurodegenerative disease primarily characterized by cerebellar degeneration in children leading to motor impairment. The disease progresses with other clinical manifestations including oculocutaneous telangiectasia, immune disorders, increased susceptibly to cancer and respiratory infections. Although genetic investigations and physiological models have established the l...

  19. Establishing a Reproducible Hypertrophic Scar following Thermal Injury: A Porcine Model

    Directory of Open Access Journals (Sweden)

    Scott J. Rapp, MD

    2015-02-01

    Conclusions: Deep partial-thickness thermal injury to the back of domestic swine produces an immature hypertrophic scar by 10 weeks following burn with thickness appearing to coincide with the location along the dorsal axis. With minimal pig to pig variation, we describe our technique to provide a testable immature scar model.

  20. Reproducibility of a novel model of murine asthma-like pulmonary inflammation.

    Science.gov (United States)

    McKinley, L; Kim, J; Bolgos, G L; Siddiqui, J; Remick, D G

    2004-05-01

    Sensitization to cockroach allergens (CRA) has been implicated as a major cause of asthma, especially among inner-city populations. Endotoxin from Gram-negative bacteria has also been investigated for its role in attenuating or exacerbating the asthmatic response. We have created a novel model utilizing house dust extract (HDE) containing high levels of both CRA and endotoxin to induce pulmonary inflammation (PI) and airway hyperresponsiveness (AHR). A potential drawback of this model is that the HDE is in limited supply and preparation of new HDE will not contain the exact components of the HDE used to define our model system. The present study involved testing HDEs collected from various homes for their ability to cause PI and AHR. Dust collected from five homes was extracted in phosphate buffered saline overnight. The levels of CRA and endotoxin in the supernatants varied from 7.1 to 49.5 mg/ml of CRA and 1.7-6 micro g/ml of endotoxin in the HDEs. Following immunization and two pulmonary exposures to HDE all five HDEs induced AHR, PI and plasma IgE levels substantially higher than normal mice. This study shows that HDE containing high levels of cockroach allergens and endotoxin collected from different sources can induce an asthma-like response in our murine model.

  1. A Model of Successful School Leadership from the International Successful School Principalship Project

    Directory of Open Access Journals (Sweden)

    David Gurr

    2015-03-01

    Full Text Available The International Successful School Principalship Project (ISSPP has been actively conducting research about the work of successful principals since 2001. Findings from four project books and eight models derived from this project are synthesised into a model of successful school leadership. Building on Gurr, Drysdale and Mulford’s earlier model, the work of school leaders is described as engaging within the school context to influence student and school outcomes through interventions in teaching and learning, school capacity building, and the wider context. The qualities a leader brings to their role, a portfolio approach to using leadership ideas, constructing networks, collaborations and partnerships, and utilising accountability and evaluation for evidence-informed improvement, are important additional elements. The model is applicable to all in leadership roles in schools.

  2. A computational model incorporating neural stem cell dynamics reproduces glioma incidence across the lifespan in the human population.

    Directory of Open Access Journals (Sweden)

    Roman Bauer

    Full Text Available Glioma is the most common form of primary brain tumor. Demographically, the risk of occurrence increases until old age. Here we present a novel computational model to reproduce the probability of glioma incidence across the lifespan. Previous mathematical models explaining glioma incidence are framed in a rather abstract way, and do not directly relate to empirical findings. To decrease this gap between theory and experimental observations, we incorporate recent data on cellular and molecular factors underlying gliomagenesis. Since evidence implicates the adult neural stem cell as the likely cell-of-origin of glioma, we have incorporated empirically-determined estimates of neural stem cell number, cell division rate, mutation rate and oncogenic potential into our model. We demonstrate that our model yields results which match actual demographic data in the human population. In particular, this model accounts for the observed peak incidence of glioma at approximately 80 years of age, without the need to assert differential susceptibility throughout the population. Overall, our model supports the hypothesis that glioma is caused by randomly-occurring oncogenic mutations within the neural stem cell population. Based on this model, we assess the influence of the (experimentally indicated decrease in the number of neural stem cells and increase of cell division rate during aging. Our model provides multiple testable predictions, and suggests that different temporal sequences of oncogenic mutations can lead to tumorigenesis. Finally, we conclude that four or five oncogenic mutations are sufficient for the formation of glioma.

  3. [Renaissance of training in general surgery in Cambodia: a unique experience or reproducible model].

    Science.gov (United States)

    Dumurgier, C; Baulieux, J

    2005-01-01

    Is the new surgical training program at the University of Phom-Penh, Cambodia a unique experience or can it serve as a model for developing countries? This report describes the encouraging first results of this didactic and hands-on surgical program. Based on their findings the authors recommend not only continuing the program in Phom-Penh but also proposing slightly modified versions to new medical universities not currently offering specialization in surgery.

  4. Evaluation of Nitinol staples for the Lapidus arthrodesis in a reproducible biomechanical model

    Directory of Open Access Journals (Sweden)

    Nicholas Alexander Russell

    2015-12-01

    Full Text Available While the Lapidus procedure is a widely accepted technique for treatment of hallux valgus, the optimal fixation method to maintain joint stability remains controversial. The purpose of this study was to evaluate the biomechanical properties of new Shape Memory Alloy staples arranged in different configurations in a repeatable 1st Tarsometatarsal arthrodesis model. Ten sawbones models of the whole foot (n=5 per group were reconstructed using a single dorsal staple or two staples in a delta configuration. Each construct was mechanically tested in dorsal four-point bending, medial four-point bending, dorsal three-point bending and plantar cantilever bending with the staples activated at 37°C. The peak load, stiffness and plantar gapping were determined for each test. Pressure sensors were used to measure the contact force and area of the joint footprint in each group. There was a significant (p < 0.05 increase in peak load in the two staple constructs compared to the single staple constructs for all testing modalities. Stiffness also increased significantly in all tests except dorsal four-point bending. Pressure sensor readings showed a significantly higher contact force at time zero and contact area following loading in the two staple constructs (p < 0.05. Both groups completely recovered any plantar gapping following unloading and restored their initial contact footprint. The biomechanical integrity and repeatability of the models was demonstrated with no construct failures due to hardware or model breakdown. Shape memory alloy staples provide fixation with the ability to dynamically apply and maintain compression across a simulated arthrodesis following a range of loading conditions.

  5. Can lagrangian models reproduce the migration time of European eel obtained from otolith analysis?

    Science.gov (United States)

    Rodríguez-Díaz, L.; Gómez-Gesteira, M.

    2017-12-01

    European eel can be found at the Bay of Biscay after a long migration across the Atlantic. The duration of migration, which takes place at larval stage, is of primary importance to understand eel ecology and, hence, its survival. This duration is still a controversial matter since it can range from 7 months to > 4 years depending on the method to estimate duration. The minimum migration duration estimated from our lagrangian model is similar to the duration obtained from the microstructure of eel otoliths, which is typically on the order of 7-9 months. The lagrangian model showed to be sensitive to different conditions like spatial and time resolution, release depth, release area and initial distribution. In general, migration showed to be faster when decreasing the depth and increasing the resolution of the model. In average, the fastest migration was obtained when only advective horizontal movement was considered. However, faster migration was even obtained in some cases when locally oriented random migration was taken into account.

  6. Acute multi-sgRNA knockdown of KEOPS complex genes reproduces the microcephaly phenotype of the stable knockout zebrafish model.

    Directory of Open Access Journals (Sweden)

    Tilman Jobst-Schwan

    Full Text Available Until recently, morpholino oligonucleotides have been widely employed in zebrafish as an acute and efficient loss-of-function assay. However, off-target effects and reproducibility issues when compared to stable knockout lines have compromised their further use. Here we employed an acute CRISPR/Cas approach using multiple single guide RNAs targeting simultaneously different positions in two exemplar genes (osgep or tprkb to increase the likelihood of generating mutations on both alleles in the injected F0 generation and to achieve a similar effect as morpholinos but with the reproducibility of stable lines. This multi single guide RNA approach resulted in median likelihoods for at least one mutation on each allele of >99% and sgRNA specific insertion/deletion profiles as revealed by deep-sequencing. Immunoblot showed a significant reduction for Osgep and Tprkb proteins. For both genes, the acute multi-sgRNA knockout recapitulated the microcephaly phenotype and reduction in survival that we observed previously in stable knockout lines, though milder in the acute multi-sgRNA knockout. Finally, we quantify the degree of mutagenesis by deep sequencing, and provide a mathematical model to quantitate the chance for a biallelic loss-of-function mutation. Our findings can be generalized to acute and stable CRISPR/Cas targeting for any zebrafish gene of interest.

  7. Realizing the Living Paper using the ProvONE Model for Reproducible Research

    Science.gov (United States)

    Jones, M. B.; Jones, C. S.; Ludäscher, B.; Missier, P.; Walker, L.; Slaughter, P.; Schildhauer, M.; Cuevas-Vicenttín, V.

    2015-12-01

    Science has advanced through traditional publications that codify research results as a permenant part of the scientific record. But because publications are static and atomic, researchers can only cite and reference a whole work when building on prior work of colleagues. The open source software model has demonstrated a new approach in which strong version control in an open environment can nurture an open ecosystem of software. Developers now commonly fork and extend software giving proper credit, with less repetition, and with confidence in the relationship to original software. Through initiatives like 'Beyond the PDF', an analogous model has been imagined for open science, in which software, data, analyses, and derived products become first class objects within a publishing ecosystem that has evolved to be finer-grained and is realized through a web of linked open data. We have prototyped a Living Paper concept by developing the ProvONE provenance model for scientific workflows, with prototype deployments in DataONE. ProvONE promotes transparency and openness by describing the authenticity, origin, structure, and processing history of research artifacts and by detailing the steps in computational workflows that produce derived products. To realize the Living Paper, we decompose scientific papers into their constituent products and publish these as compound objects in the DataONE federation of archival repositories. Each individual finding and sub-product of a reseach project (such as a derived data table, a workflow or script, a figure, an image, or a finding) can be independently stored, versioned, and cited. ProvONE provenance traces link these fine-grained products within and across versions of a paper, and across related papers that extend an original analysis. This allows for open scientific publishing in which researchers extend and modify findings, creating a dynamic, evolving web of results that collectively represent the scientific enterprise. The

  8. A discrete particle model reproducing collective dynamics of a bee swarm.

    Science.gov (United States)

    Bernardi, Sara; Colombi, Annachiara; Scianna, Marco

    2018-02-01

    In this article, we present a microscopic discrete mathematical model describing collective dynamics of a bee swarm. More specifically, each bee is set to move according to individual strategies and social interactions, the former involving the desire to reach a target destination, the latter accounting for repulsive/attractive stimuli and for alignment processes. The insects tend in fact to remain sufficiently close to the rest of the population, while avoiding collisions, and they are able to track and synchronize their movement to the flight of a given set of neighbors within their visual field. The resulting collective behavior of the bee cloud therefore emerges from non-local short/long-range interactions. Differently from similar approaches present in the literature, we here test different alignment mechanisms (i.e., based either on an Euclidean or on a topological neighborhood metric), which have an impact also on the other social components characterizing insect behavior. A series of numerical realizations then shows the phenomenology of the swarm (in terms of pattern configuration, collective productive movement, and flight synchronization) in different regions of the space of free model parameters (i.e., strength of attractive/repulsive forces, extension of the interaction regions). In this respect, constraints in the possible variations of such coefficients are here given both by reasonable empirical observations and by analytical results on some stability characteristics of the defined pairwise interaction kernels, which have to assure a realistic crystalline configuration of the swarm. An analysis of the effect of unconscious random fluctuations of bee dynamics is also provided. Copyright © 2018 Elsevier Ltd. All rights reserved.

  9. Sprague-Dawley rats are a sustainable and reproducible animal model for induction and study of oral submucous fibrosis

    Directory of Open Access Journals (Sweden)

    Shilpa Maria

    2015-01-01

    Full Text Available Background: Oral submucous fibrosis (OSF is a chronic debilitating disease predominantly affecting the oral cavity and oropharynx. Characteristic histological traits of OSF include epithelial atrophy, inflammation, and a generalized submucosal fibrosis. Several studies and epidemiological surveys provide substantial evidence that areca nut is the main etiological factor for OSF. Hesitance of patients to undergo biopsy procedure together with clinicians becoming increasingly reluctant to take biopsies in cases of OSF has prompted researchers to develop animal models to study the disease process. Materials and Methods: The present study evaluates the efficacy, sustainability, and reproducibility of using Sprague-Dawley (SD rats as a possible model in the induction and progression of OSF. Buccal mucosa of SD rats was injected with areca nut and pan masala solutions on alternate days over a period of 48 weeks. The control group was treated with saline. The influence of areca nut and pan masala on the oral epithelium and connective tissue was evaluated by light microscopy. Results: Oral submucous fibrosis-like lesions were seen in both the areca nut and pan masala treated groups. The histological changes observed included: Atrophic epithelium, partial or complete loss of rete ridges, juxta-epithelial hyalinization, inflammation and accumulation of dense bundles of collagen fibers subepithelially. Conclusions: Histopathological changes in SD rats following treatment with areca nut and pan masala solutions bears a close semblance to that seen in humans with OSF. The SD rats seem to be a cheap and efficient, sustainable and reproducible model for the induction and development of OSF.

  10. The diverse broad-band light-curves of Swift GRBs reproduced with the cannonball model

    CERN Document Server

    Dado, Shlomo; De Rújula, A

    2009-01-01

    Two radiation mechanisms, inverse Compton scattering (ICS) and synchrotron radiation (SR), suffice within the cannonball (CB) model of long gamma ray bursts (LGRBs) and X-ray flashes (XRFs) to provide a very simple and accurate description of their observed prompt emission and afterglows. Simple as they are, the two mechanisms and the burst environment generate the rich structure of the light curves at all frequencies and times. This is demonstrated for 33 selected Swift LGRBs and XRFs, which are well sampled from early time until late time and well represent the entire diversity of the broad band light curves of Swift LGRBs and XRFs. Their prompt gamma-ray and X-ray emission is dominated by ICS of glory light. During their fast decline phase, ICS is taken over by SR which dominates their broad band afterglow. The pulse shape and spectral evolution of the gamma-ray peaks and the early-time X-ray flares, and even the delayed optical `humps' in XRFs, are correctly predicted. The canonical and non-canonical X-ra...

  11. A Labor Market Success Model of Young Male Hispanic Americans.

    Science.gov (United States)

    Seidenstat, Paul

    The study develops a labor market success model of young male inner-city Hispanics and examines several variables influencing labor market success. A sample of inner-city Puerto Ricans who attended the eighth grade in two schools in Wilmington, Delaware, in the 1966-1971 period was chosen and interviewed. Small control groups of blacks and whites…

  12. End Users and ERP Systems� Success. Three Models

    Directory of Open Access Journals (Sweden)

    Gianina MIHAI

    2017-06-01

    Full Text Available Information systems (IS have an enormous impact on organizations, individual work, and performance in general. As a result, many research works in the field of IS are focused on the interrelationship between individual performance and IS performance. During the last 20 to 30 years many models have been developed and tested by researchers. Their main objective was to investigate IS success and user performance in different environments. Therefore, a number of models appeared, their goal being the studying of the success, usefulness, end user adoption and utilization of IS, and other user and IS-related aspects in different organizations. This research paper presents three of the most important models developed in specialized literature, which deal with measuring IS success and end user adoption of the IS: the TAM model, the D&M model, and the TTF model. The research also provides an overview of some studies that have applied these models in the field of ERP systems.

  13. Comparative analysis of 5 lung cancer natural history and screening models that reproduce outcomes of the NLST and PLCO trials.

    Science.gov (United States)

    Meza, Rafael; ten Haaf, Kevin; Kong, Chung Yin; Erdogan, Ayca; Black, William C; Tammemagi, Martin C; Choi, Sung Eun; Jeon, Jihyoun; Han, Summer S; Munshi, Vidit; van Rosmalen, Joost; Pinsky, Paul; McMahon, Pamela M; de Koning, Harry J; Feuer, Eric J; Hazelton, William D; Plevritis, Sylvia K

    2014-06-01

    The National Lung Screening Trial (NLST) demonstrated that low-dose computed tomography screening is an effective way of reducing lung cancer (LC) mortality. However, optimal screening strategies have not been determined to date and it is uncertain whether lighter smokers than those examined in the NLST may also benefit from screening. To address these questions, it is necessary to first develop LC natural history models that can reproduce NLST outcomes and simulate screening programs at the population level. Five independent LC screening models were developed using common inputs and calibration targets derived from the NLST and the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO). Imputation of missing information regarding smoking, histology, and stage of disease for a small percentage of individuals and diagnosed LCs in both trials was performed. Models were calibrated to LC incidence, mortality, or both outcomes simultaneously. Initially, all models were calibrated to the NLST and validated against PLCO. Models were found to validate well against individuals in PLCO who would have been eligible for the NLST. However, all models required further calibration to PLCO to adequately capture LC outcomes in PLCO never-smokers and light smokers. Final versions of all models produced incidence and mortality outcomes in the presence and absence of screening that were consistent with both trials. The authors developed 5 distinct LC screening simulation models based on the evidence in the NLST and PLCO. The results of their analyses demonstrated that the NLST and PLCO have produced consistent results. The resulting models can be important tools to generate additional evidence to determine the effectiveness of lung cancer screening strategies using low-dose computed tomography. © 2014 American Cancer Society.

  14. Establishing a Cloud Computing Success Model for Hospitals in Taiwan.

    Science.gov (United States)

    Lian, Jiunn-Woei

    2017-01-01

    The purpose of this study is to understand the critical quality-related factors that affect cloud computing success of hospitals in Taiwan. In this study, private cloud computing is the major research target. The chief information officers participated in a questionnaire survey. The results indicate that the integration of trust into the information systems success model will have acceptable explanatory power to understand cloud computing success in the hospital. Moreover, information quality and system quality directly affect cloud computing satisfaction, whereas service quality indirectly affects the satisfaction through trust. In other words, trust serves as the mediator between service quality and satisfaction. This cloud computing success model will help hospitals evaluate or achieve success after adopting private cloud computing health care services.

  15. Establishing a Cloud Computing Success Model for Hospitals in Taiwan

    Directory of Open Access Journals (Sweden)

    Jiunn-Woei Lian PhD

    2017-01-01

    Full Text Available The purpose of this study is to understand the critical quality-related factors that affect cloud computing success of hospitals in Taiwan. In this study, private cloud computing is the major research target. The chief information officers participated in a questionnaire survey. The results indicate that the integration of trust into the information systems success model will have acceptable explanatory power to understand cloud computing success in the hospital. Moreover, information quality and system quality directly affect cloud computing satisfaction, whereas service quality indirectly affects the satisfaction through trust. In other words, trust serves as the mediator between service quality and satisfaction. This cloud computing success model will help hospitals evaluate or achieve success after adopting private cloud computing health care services.

  16. Can the CMIP5 models reproduce interannual to interdecadal southern African summer rainfall variability and their teleconnections?

    Science.gov (United States)

    Dieppois, Bastien; Pohl, Benjamin; Crétat, Julien; Keenlyside, Noel; New, Mark

    2017-04-01

    This study examines for the first time the ability of 28 global climate models from the Coupled Model Intercomparison Project 5 (CMIP5) to reproduce southern African summer rainfall variability and their teleconnections with large-scale modes of climate variability across the dominant timescales. In observations, summer southern African rainfall exhibits three significant timescales of variability over the twentieth century: interdecadal (15-28 years), quasi-decadal (8-13 years), and interannual (2-8 years). Most of CMIP5 simulations underestimate southern African summer rainfall variability at these three timescales, and this bias is proportionally stronger from high- to low-frequency. The inter-model spread is as important as the spread between the ensemble members of a given model, which suggests a strong influence of internal climate variability, and/or large model uncertainties. The underestimated amplitude of rainfall variability for each timescale are linked to unrealistic spatial distributions of these fluctuations over the subcontinent in most CMIP5 models. This is, at least partially, due to a poor representation of the tropical/subtropical teleconnections, which are known to favour wet conditions over southern African rainfall in the observations. Most CMIP5 realisations (85%) fail at simulating sea-surface temperature (SST) anomalies related to a negative Pacific Decadal Oscillation during wetter conditions at the interdecadal timescale. At the quasi-decadal timescale, only one-third of simulations display a negative Interdecadal Pacific Oscillation during wetter conditions, but these SST anomalies are anomalously shifted westward and poleward when compared to observed anomalies. Similar biases in simulating La Niña SST anomalies are identified in more than 50% of CMIP5 simulations at the interannual timescale. These biases in Pacific SST anomalies result in important shifts in the Walker circulation. This impacts southern Africa rainfall variability

  17. Models Predicting Success of Infertility Treatment: A Systematic Review

    Science.gov (United States)

    Zarinara, Alireza; Zeraati, Hojjat; Kamali, Koorosh; Mohammad, Kazem; Shahnazari, Parisa; Akhondi, Mohammad Mehdi

    2016-01-01

    Background: Infertile couples are faced with problems that affect their marital life. Infertility treatment is expensive and time consuming and occasionally isn’t simply possible. Prediction models for infertility treatment have been proposed and prediction of treatment success is a new field in infertility treatment. Because prediction of treatment success is a new need for infertile couples, this paper reviewed previous studies for catching a general concept in applicability of the models. Methods: This study was conducted as a systematic review at Avicenna Research Institute in 2015. Six data bases were searched based on WHO definitions and MESH key words. Papers about prediction models in infertility were evaluated. Results: Eighty one papers were eligible for the study. Papers covered years after 1986 and studies were designed retrospectively and prospectively. IVF prediction models have more shares in papers. Most common predictors were age, duration of infertility, ovarian and tubal problems. Conclusion: Prediction model can be clinically applied if the model can be statistically evaluated and has a good validation for treatment success. To achieve better results, the physician and the couples’ needs estimation for treatment success rate were based on history, the examination and clinical tests. Models must be checked for theoretical approach and appropriate validation. The privileges for applying the prediction models are the decrease in the cost and time, avoiding painful treatment of patients, assessment of treatment approach for physicians and decision making for health managers. The selection of the approach for designing and using these models is inevitable. PMID:27141461

  18. Can CFMIP2 models reproduce the leading modes of cloud vertical structure in the CALIPSO-GOCCP observations?

    Science.gov (United States)

    Wang, Fang; Yang, Song

    2018-02-01

    Using principal component (PC) analysis, three leading modes of cloud vertical structure (CVS) are revealed by the GCM-Oriented CALIPSO Cloud Product (GOCCP), i.e. tropical high, subtropical anticyclonic and extratropical cyclonic cloud modes (THCM, SACM and ECCM, respectively). THCM mainly reflect the contrast between tropical high clouds and clouds in middle/high latitudes. SACM is closely associated with middle-high clouds in tropical convective cores, few-cloud regimes in subtropical anticyclonic clouds and stratocumulus over subtropical eastern oceans. ECCM mainly corresponds to clouds along extratropical cyclonic regions. Models of phase 2 of Cloud Feedback Model Intercomparison Project (CFMIP2) well reproduce the THCM, but SACM and ECCM are generally poorly simulated compared to GOCCP. Standardized PCs corresponding to CVS modes are generally captured, whereas original PCs (OPCs) are consistently underestimated (overestimated) for THCM (SACM and ECCM) by CFMIP2 models. The effects of CVS modes on relative cloud radiative forcing (RSCRF/RLCRF) (RSCRF being calculated at the surface while RLCRF at the top of atmosphere) are studied in terms of principal component regression method. Results show that CFMIP2 models tend to overestimate (underestimated or simulate the opposite sign) RSCRF/RLCRF radiative effects (REs) of ECCM (THCM and SACM) in unit global mean OPC compared to observations. These RE biases may be attributed to two factors, one of which is underestimation (overestimation) of low/middle clouds (high clouds) (also known as stronger (weaker) REs in unit low/middle (high) clouds) in simulated global mean cloud profiles, the other is eigenvector biases in CVS modes (especially for SACM and ECCM). It is suggested that much more attention should be paid on improvement of CVS, especially cloud parameterization associated with particular physical processes (e.g. downwelling regimes with the Hadley circulation, extratropical storm tracks and others), which

  19. Reproducing Electric Field Observations during Magnetic Storms by means of Rigorous 3-D Modelling and Distortion Matrix Co-estimation

    Science.gov (United States)

    Püthe, Christoph; Manoj, Chandrasekharan; Kuvshinov, Alexey

    2015-04-01

    Electric fields induced in the conducting Earth during magnetic storms drive currents in power transmission grids, telecommunication lines or buried pipelines. These geomagnetically induced currents (GIC) can cause severe service disruptions. The prediction of GIC is thus of great importance for public and industry. A key step in the prediction of the hazard to technological systems during magnetic storms is the calculation of the geoelectric field. To address this issue for mid-latitude regions, we developed a method that involves 3-D modelling of induction processes in a heterogeneous Earth and the construction of a model of the magnetospheric source. The latter is described by low-degree spherical harmonics; its temporal evolution is derived from observatory magnetic data. Time series of the electric field can be computed for every location on Earth's surface. The actual electric field however is known to be perturbed by galvanic effects, arising from very local near-surface heterogeneities or topography, which cannot be included in the conductivity model. Galvanic effects are commonly accounted for with a real-valued time-independent distortion matrix, which linearly relates measured and computed electric fields. Using data of various magnetic storms that occurred between 2000 and 2003, we estimated distortion matrices for observatory sites onshore and on the ocean bottom. Strong correlations between modellings and measurements validate our method. The distortion matrix estimates prove to be reliable, as they are accurately reproduced for different magnetic storms. We further show that 3-D modelling is crucial for a correct separation of galvanic and inductive effects and a precise prediction of electric field time series during magnetic storms. Since the required computational resources are negligible, our approach is suitable for a real-time prediction of GIC. For this purpose, a reliable forecast of the source field, e.g. based on data from satellites

  20. A Career Success Model for Academics at Malaysian Research Universities

    Science.gov (United States)

    Abu Said, Al-Mansor; Mohd Rasdi, Roziah; Abu Samah, Bahaman; Silong, Abu Daud; Sulaiman, Suzaimah

    2015-01-01

    Purpose: The purpose of this paper is to develop a career success model for academics at the Malaysian research universities. Design/methodology/approach: Self-administered and online surveys were used for data collection among 325 academics from Malaysian research universities. Findings: Based on the analysis of structural equation modeling, the…

  1. Empirical evaluation of a forecasting model for successful facilitation ...

    African Journals Online (AJOL)

    The forecasting model identified 8 key attributes for facilitation success based on performance measures from the 1999 Facilitator Customer Service Survey. During 2000 the annual Facilitator Customer Satisfaction Survey was employed to validate the findings of the forecasting model. A total of 1910 questionnaires were ...

  2. QSAR model reproducibility and applicability: a case study of rate constants of hydroxyl radical reaction models applied to polybrominated diphenyl ethers and (benzo-)triazoles.

    Science.gov (United States)

    Roy, Partha Pratim; Kovarich, Simona; Gramatica, Paola

    2011-08-01

    The crucial importance of the three central OECD principles for quantitative structure-activity relationship (QSAR) model validation is highlighted in a case study of tropospheric degradation of volatile organic compounds (VOCs) by OH, applied to two CADASTER chemical classes (PBDEs and (benzo-)triazoles). The application of any QSAR model to chemicals without experimental data largely depends on model reproducibility by the user. The reproducibility of an unambiguous algorithm (OECD Principle 2) is guaranteed by redeveloping MLR models based on both updated version of DRAGON software for molecular descriptors calculation and some freely available online descriptors. The Genetic Algorithm has confirmed its ability to always select the most informative descriptors independently on the input pool of variables. The ability of the GA-selected descriptors to model chemicals not used in model development is verified by three different splittings (random by response, K-ANN and K-means clustering), thus ensuring the external predictivity of the new models, independently of the training/prediction set composition (OECD Principle 5). The relevance of checking the structural applicability domain becomes very evident on comparing the predictions for CADASTER chemicals, using the new models proposed herein, with those obtained by EPI Suite. Copyright © 2011 Wiley Periodicals, Inc.

  3. Contextual sensitivity in scientific reproducibility.

    Science.gov (United States)

    Van Bavel, Jay J; Mende-Siedlecki, Peter; Brady, William J; Reinero, Diego A

    2016-06-07

    In recent years, scientists have paid increasing attention to reproducibility. For example, the Reproducibility Project, a large-scale replication attempt of 100 studies published in top psychology journals found that only 39% could be unambiguously reproduced. There is a growing consensus among scientists that the lack of reproducibility in psychology and other fields stems from various methodological factors, including low statistical power, researcher's degrees of freedom, and an emphasis on publishing surprising positive results. However, there is a contentious debate about the extent to which failures to reproduce certain results might also reflect contextual differences (often termed "hidden moderators") between the original research and the replication attempt. Although psychologists have found extensive evidence that contextual factors alter behavior, some have argued that context is unlikely to influence the results of direct replications precisely because these studies use the same methods as those used in the original research. To help resolve this debate, we recoded the 100 original studies from the Reproducibility Project on the extent to which the research topic of each study was contextually sensitive. Results suggested that the contextual sensitivity of the research topic was associated with replication success, even after statistically adjusting for several methodological characteristics (e.g., statistical power, effect size). The association between contextual sensitivity and replication success did not differ across psychological subdisciplines. These results suggest that researchers, replicators, and consumers should be mindful of contextual factors that might influence a psychological process. We offer several guidelines for dealing with contextual sensitivity in reproducibility.

  4. Eccentric Contraction-Induced Muscle Injury: Reproducible, Quantitative, Physiological Models to Impair Skeletal Muscle’s Capacity to Generate Force

    Science.gov (United States)

    Call, Jarrod A.; Lowe, Dawn A.

    2018-01-01

    In order to investigate the molecular and cellular mechanisms of muscle regeneration an experimental injury model is required. Advantages of eccentric contraction-induced injury are that it is a controllable, reproducible, and physiologically relevant model to cause muscle injury, with injury being defined as a loss of force generating capacity. While eccentric contractions can be incorporated into conscious animal study designs such as downhill treadmill running, electrophysiological approaches to elicit eccentric contractions and examine muscle contractility, for example before and after the injurious eccentric contractions, allows researchers to circumvent common issues in determining muscle function in a conscious animal (e.g., unwillingness to participate). Herein, we describe in vitro and in vivo methods that are reliable, repeatable, and truly maximal because the muscle contractions are evoked in a controlled, quantifiable manner independent of subject motivation. Both methods can be used to initiate eccentric contraction-induced injury and are suitable for monitoring functional muscle regeneration hours to days to weeks post-injury. PMID:27492161

  5. Eccentric Contraction-Induced Muscle Injury: Reproducible, Quantitative, Physiological Models to Impair Skeletal Muscle's Capacity to Generate Force.

    Science.gov (United States)

    Call, Jarrod A; Lowe, Dawn A

    2016-01-01

    In order to investigate the molecular and cellular mechanisms of muscle regeneration an experimental injury model is required. Advantages of eccentric contraction-induced injury are that it is a controllable, reproducible, and physiologically relevant model to cause muscle injury, with injury being defined as a loss of force generating capacity. While eccentric contractions can be incorporated into conscious animal study designs such as downhill treadmill running, electrophysiological approaches to elicit eccentric contractions and examine muscle contractility, for example before and after the injurious eccentric contractions, allows researchers to circumvent common issues in determining muscle function in a conscious animal (e.g., unwillingness to participate). Herein, we describe in vitro and in vivo methods that are reliable, repeatable, and truly maximal because the muscle contractions are evoked in a controlled, quantifiable manner independent of subject motivation. Both methods can be used to initiate eccentric contraction-induced injury and are suitable for monitoring functional muscle regeneration hours to days to weeks post-injury.

  6. Formulation of a Success Model in Pharmaceutical R&D

    Directory of Open Access Journals (Sweden)

    Hyunju Rachel Kim

    2014-03-01

    Full Text Available Recently, pharmaceutical R&D has been demanded to increase productivity in terms of time efficiency and innovation as well. There have been discontinuous challenges coming up in this industry, such as globalized R&D competition, stricter regulation, lengthy process of clinical trials, and so on. Considering external changes, high competition, and discontinuities in the industry, it is a good time to redefine the concept of success in pharmaceutical R&D. Thus, this article attempts to formulate a new success model in pharmaceutical R&D, through contextualizing the industry’s success factors.

  7. The Drivers of Success in Business Model Transformation

    Directory of Open Access Journals (Sweden)

    Nenad Savič

    2016-01-01

    Full Text Available Existing empirical literature on business models is still inconclusive about the key drivers of successful business model transformation. The paper explores this issue by using a single longitudinal case study design in combination with grounded theory approach on a medium-sized, high-tech and globally oriented company. Based on on-site visits, interviews and secondary documentation data analysis, the study identifies six generic drivers of successful business model transformation: transformational leadership, discovery driven decision-making, industry improvement – customer specific orientation, content-oriented communication, self-initiative collaborators, and phased separation strategy. The new drivers supplement our existing knowledge on how successful transformation takes place and add to existing drivers, while extensive discussion of their implications may help the managers to execute business transformations more effectively.

  8. A rat model of post-traumatic stress disorder reproduces the hippocampal deficits seen in the human syndrome

    Directory of Open Access Journals (Sweden)

    Sonal eGoswami

    2012-06-01

    Full Text Available Despite recent progress, the causes and pathophysiology of post-traumatic stress disorder (PTSD remain poorly understood, partly because of ethical limitations inherent to human studies. One approach to circumvent this obstacle is to study PTSD in a valid animal model of the human syndrome. In one such model, extreme and long-lasting behavioral manifestations of anxiety develop in a subset of Lewis rats after exposure to an intense predatory threat that mimics the type of life-and-death situation known to precipitate PTSD in humans. This study aimed to assess whether the hippocampus-associated deficits observed in the human syndrome are reproduced in this rodent model. Prior to predatory threat, different groups of rats were each tested on one of three object recognition memory tasks that varied in the types of contextual clues (i.e. that require the hippocampus or not the rats could use to identify novel items. After task completion, the rats were subjected to predatory threat and, one week later, tested on the elevated plus maze. Based on their exploratory behavior in the plus maze, rats were then classified as resilient or PTSD-like and their performance on the pre-threat object recognition tasks compared. The performance of PTSD-like rats was inferior to that of resilient rats but only when subjects relied on an allocentric frame of reference to identify novel items, a process thought to be critically dependent on the hippocampus. Therefore, these results suggest that even prior to trauma, PTSD-like rats show a deficit in hippocampal-dependent functions, as reported in twin studies of human PTSD.

  9. Reproducing the organic matter model of anthropogenic dark earth of Amazonia and testing the ecotoxicity of functionalized charcoal compounds

    Directory of Open Access Journals (Sweden)

    Carolina Rodrigues Linhares

    2012-05-01

    Full Text Available The objective of this work was to obtain organic compounds similar to the ones found in the organic matter of anthropogenic dark earth of Amazonia (ADE using a chemical functionalization procedure on activated charcoal, as well as to determine their ecotoxicity. Based on the study of the organic matter from ADE, an organic model was proposed and an attempt to reproduce it was described. Activated charcoal was oxidized with the use of sodium hypochlorite at different concentrations. Nuclear magnetic resonance was performed to verify if the spectra of the obtained products were similar to the ones of humic acids from ADE. The similarity between spectra indicated that the obtained products were polycondensed aromatic structures with carboxyl groups: a soil amendment that can contribute to soil fertility and to its sustainable use. An ecotoxicological test with Daphnia similis was performed on the more soluble fraction (fulvic acids of the produced soil amendment. Aryl chloride was formed during the synthesis of the organic compounds from activated charcoal functionalization and partially removed through a purification process. However, it is probable that some aryl chloride remained in the final product, since the ecotoxicological test indicated that the chemical functionalized soil amendment is moderately toxic.

  10. Forest-succession models and their ecological and management implications

    Energy Technology Data Exchange (ETDEWEB)

    West, D.; Smith, T.M.; Weinstein, D.A.; Shugart, H.H.

    1981-01-01

    Computer models of forest succession have been developed to an extent that allows their use as a tool for predicting forest ecosystem behavior over long periods of time. This paper outlines the use of one approach to forest succession modeling for a variety of problems including: (1) determining the effect of climate change on forests; (2) integrating information on wildlife habitat changes with the changes in forest structure associated with timber management; (3) assessing the potential effect of air pollutants on forest dynamics; and (4) determining the theoretical importance of disturbance on forest community diversity and function.

  11. Validity, reliability, and reproducibility of linear measurements on digital models obtained from intraoral and cone-beam computed tomography scans of alginate impressions

    NARCIS (Netherlands)

    Wiranto, Matthew G.; Engelbrecht, W. Petrie; Nolthenius, Heleen E. Tutein; van der Meer, W. Joerd; Ren, Yijin

    INTRODUCTION: Digital 3-dimensional models are widely used for orthodontic diagnosis. The aim of this study was to assess the validity, reliability, and reproducibility of digital models obtained from the Lava Chairside Oral scanner (3M ESPE, Seefeld, Germany) and cone-beam computed tomography scans

  12. Reproducibility and accuracy of linear measurements on dental models derived from cone-beam computed tomography compared with digital dental casts

    NARCIS (Netherlands)

    Waard, O. de; Rangel, F.A.; Fudalej, P.S.; Bronkhorst, E.M.; Kuijpers-Jagtman, A.M.; Breuning, K.H.

    2014-01-01

    INTRODUCTION: The aim of this study was to determine the reproducibility and accuracy of linear measurements on 2 types of dental models derived from cone-beam computed tomography (CBCT) scans: CBCT images, and Anatomodels (InVivoDental, San Jose, Calif); these were compared with digital models

  13. Electronic Commerce Success Model: A Search for Multiple Criteria

    Directory of Open Access Journals (Sweden)

    Didi Achjari

    2004-01-01

    Full Text Available The current study attempts to develop and examine framework of e-commerce success. In order to obtain comprehensive and robust measures, the framework accomodates key factors that are identified in the literature concerning the success of electronic commerce. The structural model comprises of four exogenous variables (Internal Driver, Internal Impediment, External Driver and Exgternal Impediment and one endogenous variable (Electornic Commerce Success eith 24 observed variables. The study that was administered within large Australian companies using questionaire survey concluded that benefits for both internal organization and external parties from the use of e-commerce were the main factor tro predict perceived and/or expected success of electronic commerce.

  14. Inhibition of basophil activation by histamine: a sensitive and reproducible model for the study of the biological activity of high dilutions.

    Science.gov (United States)

    Sainte-Laudy, J; Belon, Ph

    2009-10-01

    (another human basophil activation marker). Results were expressed in mean fluorescence intensity of the CD203c positive population (MFI-CD203c) and an activation index calculated by an algorithm. For the mouse basophil model, histamine was measured spectrofluorimetrically. The main results obtained over 28 years of work was the demonstration of a reproducible inhibition of human basophil activation by high dilutions of histamine, the effect peaks in the range of 15-17CH. The effect was not significant when histamine was replaced by histidine (a histamine precursor) or cimetidine (histamine H2 receptor antagonist) was added to the incubation medium. These results were confirmed by flow cytometry. Using the latter technique, we also showed that 4-Methyl histamine (H2 agonist) induced a similar effect, in contrast to 1-Methyl histamine, an inactive histamine metabolite. Using the mouse model, we showed that histamine high dilutions, in the same range of dilutions, inhibited histamine release. Successively, using different models to study of human and murine basophil activation, we demonstrated that high dilutions of histamine, in the range of 15-17CH induce a reproducible biological effect. This phenomenon has been confirmed by a multi-center study using the HBDT model and by at least three independent laboratories by flow cytometry. The specificity of the observed effect was confirmed, versus the water controls at the same dilution level by the absence of biological activity of inactive compounds such as histidine and 1-Methyl histamine and by the reversibility of this effect in the presence of a histamine receptor H2 antagonist.

  15. A Lotka-Volterra competition model with seasonal succession.

    Science.gov (United States)

    Hsu, Sze-Bi; Zhao, Xiao-Qiang

    2012-01-01

    A complete classification for the global dynamics of a Lotka-Volterra two species competition model with seasonal succession is obtained via the stability analysis of equilibria and the theory of monotone dynamical systems. The effects of two death rates in the bad season and the proportion of the good season on the competition outcomes are also discussed. © Springer-Verlag 2011

  16. Leader Succession: A Model and Review for School Settings.

    Science.gov (United States)

    Miskel, Cecil; Cosgrove, Dorothy

    Recent research casts doubt on the commonly held notions that administrators affect student learning through instructional leadership and that changing administrators will improve school performance. To help construct a model for examining the process of leader succession that specifies a number of major school process and outcome variables…

  17. Student Success in College Composition through the Puente Project Model.

    Science.gov (United States)

    Jaffe, Barbara

    Much can be learned from California's Puente Project Model that would help students' success in classrooms as well as in college in general, and in their daily lives. Puente, which means "bridge" in Spanish, began in 1982 at Chabot College in northern California and is now in 38 colleges and 19 high schools statewide. Originally designed…

  18. Using landscape disturbance and succession models to support forest management

    Science.gov (United States)

    Eric J. Gustafson; Brian R. Sturtevant; Anatoly S. Shvidenko; Robert M. Scheller

    2010-01-01

    Managers of forested landscapes must account for multiple, interacting ecological processes operating at broad spatial and temporal scales. These interactions can be of such complexity that predictions of future forest ecosystem states are beyond the analytical capability of the human mind. Landscape disturbance and succession models (LDSM) are predictive and...

  19. A Competitive Success Model in the Hotel Industry

    OpenAIRE

    González Rodríguez, María Rosario; Martín Samper, Rosario del Carmen; Jiménez Caballero, José Luis

    2015-01-01

    The aim of the paper focus on identifying those factors involved in the competitive success of hotel companies and the interrelations between them, taking into account the socio-economic influence that these companies might have on Andalusian region and the few studies carried out in tourism sector so far. The study tries to specify an econometric model that may include factors that appear as mechanisms for the generation of competitive advantage. The research model allows us t...

  20. Acquisition Integration Models: How Large Companies Successfully Integrate Startups

    Directory of Open Access Journals (Sweden)

    Peter Carbone

    2011-10-01

    Full Text Available Mergers and acquisitions (M&A have been popular means for many companies to address the increasing pace and level of competition that they face. Large companies have pursued acquisitions to more quickly access technology, markets, and customers, and this approach has always been a viable exit strategy for startups. However, not all deals deliver the anticipated benefits, in large part due to poor integration of the acquired assets into the acquiring company. Integration can greatly impact the success of the acquisition and, indeed, the combined company’s overall market success. In this article, I explore the implementation of several integration models that have been put into place by a large company and extract principles that may assist negotiating parties with maximizing success. This perspective may also be of interest to smaller companies as they explore exit options while trying to ensure continued market success after acquisition. I assert that business success with acquisitions is dependent on an appropriate integration model, but that asset integration is not formulaic. Any integration effort must consider the specific market context and personnel involved.

  1. Development of a Predictive Model for Induction Success of Labour

    Directory of Open Access Journals (Sweden)

    Cristina Pruenza

    2018-03-01

    Full Text Available Induction of the labour process is an extraordinarily common procedure used in some pregnancies. Obstetricians face the need to end a pregnancy, for medical reasons usually (maternal or fetal requirements or less frequently, social (elective inductions for convenience. The success of induction procedure is conditioned by a multitude of maternal and fetal variables that appear before or during pregnancy or birth process, with a low predictive value. The failure of the induction process involves performing a caesarean section. This project arises from the clinical need to resolve a situation of uncertainty that occurs frequently in our clinical practice. Since the weight of clinical variables is not adequately weighted, we consider very interesting to know a priori the possibility of success of induction to dismiss those inductions with high probability of failure, avoiding unnecessary procedures or postponing end if possible. We developed a predictive model of induced labour success as a support tool in clinical decision making. Improve the predictability of a successful induction is one of the current challenges of Obstetrics because of its negative impact. The identification of those patients with high chances of failure, will allow us to offer them better care improving their health outcomes (adverse perinatal outcomes for mother and newborn, costs (medication, hospitalization, qualified staff and patient perceived quality. Therefore a Clinical Decision Support System was developed to give support to the Obstetricians. In this article, we had proposed a robust method to explore and model a source of clinical information with the purpose of obtaining all possible knowledge. Generally, in classification models are difficult to know the contribution that each attribute provides to the model. We had worked in this direction to offer transparency to models that may be considered as black boxes. The positive results obtained from both the

  2. The Need for Reproducibility

    Energy Technology Data Exchange (ETDEWEB)

    Robey, Robert W. [Los Alamos National Laboratory

    2016-06-27

    The purpose of this presentation is to consider issues of reproducibility, specifically it determines whether bitwise reproducible computation is possible, if computational research in DOE improves its publication process, and if reproducible results can be achieved apart from the peer review process?

  3. Reliability versus reproducibility

    International Nuclear Information System (INIS)

    Lautzenheiser, C.E.

    1976-01-01

    Defect detection and reproducibility of results are two separate but closely related subjects. It is axiomatic that a defect must be detected from examination to examination or reproducibility of results is very poor. On the other hand, a defect can be detected on each of subsequent examinations for higher reliability and still have poor reproducibility of results

  4. Synchronized mammalian cell culture: part II--population ensemble modeling and analysis for development of reproducible processes.

    Science.gov (United States)

    Jandt, Uwe; Barradas, Oscar Platas; Pörtner, Ralf; Zeng, An-Ping

    2015-01-01

    The consideration of inherent population inhomogeneities of mammalian cell cultures becomes increasingly important for systems biology study and for developing more stable and efficient processes. However, variations of cellular properties belonging to different sub-populations and their potential effects on cellular physiology and kinetics of culture productivity under bioproduction conditions have not yet been much in the focus of research. Culture heterogeneity is strongly determined by the advance of the cell cycle. The assignment of cell-cycle specific cellular variations to large-scale process conditions can be optimally determined based on the combination of (partially) synchronized cultivation under otherwise physiological conditions and subsequent population-resolved model adaptation. The first step has been achieved using the physical selection method of countercurrent flow centrifugal elutriation, recently established in our group for different mammalian cell lines which is presented in Part I of this paper series. In this second part, we demonstrate the successful adaptation and application of a cell-cycle dependent population balance ensemble model to describe and understand synchronized bioreactor cultivations performed with two model mammalian cell lines, AGE1.HNAAT and CHO-K1. Numerical adaptation of the model to experimental data allows for detection of phase-specific parameters and for determination of significant variations between different phases and different cell lines. It shows that special care must be taken with regard to the sampling frequency in such oscillation cultures to minimize phase shift (jitter) artifacts. Based on predictions of long-term oscillation behavior of a culture depending on its start conditions, optimal elutriation setup trade-offs between high cell yields and high synchronization efficiency are proposed. © 2014 American Institute of Chemical Engineers.

  5. From Peer-Reviewed to Peer-Reproduced in Scholarly Publishing: The Complementary Roles of Data Models and Workflows in Bioinformatics.

    Directory of Open Access Journals (Sweden)

    Alejandra González-Beltrán

    Full Text Available Reproducing the results from a scientific paper can be challenging due to the absence of data and the computational tools required for their analysis. In addition, details relating to the procedures used to obtain the published results can be difficult to discern due to the use of natural language when reporting how experiments have been performed. The Investigation/Study/Assay (ISA, Nanopublications (NP, and Research Objects (RO models are conceptual data modelling frameworks that can structure such information from scientific papers. Computational workflow platforms can also be used to reproduce analyses of data in a principled manner. We assessed the extent by which ISA, NP, and RO models, together with the Galaxy workflow system, can capture the experimental processes and reproduce the findings of a previously published paper reporting on the development of SOAPdenovo2, a de novo genome assembler.Executable workflows were developed using Galaxy, which reproduced results that were consistent with the published findings. A structured representation of the information in the SOAPdenovo2 paper was produced by combining the use of ISA, NP, and RO models. By structuring the information in the published paper using these data and scientific workflow modelling frameworks, it was possible to explicitly declare elements of experimental design, variables, and findings. The models served as guides in the curation of scientific information and this led to the identification of inconsistencies in the original published paper, thereby allowing its authors to publish corrections in the form of an errata.SOAPdenovo2 scripts, data, and results are available through the GigaScience Database: http://dx.doi.org/10.5524/100044; the workflows are available from GigaGalaxy: http://galaxy.cbiit.cuhk.edu.hk; and the representations using the ISA, NP, and RO models are available through the SOAPdenovo2 case study website http://isa-tools.github.io/soapdenovo2

  6. A model for successful use of student response systems.

    Science.gov (United States)

    Klein, Kathleen; Kientz, Mary

    2013-01-01

    This article presents a model developed to assist teachers in selecting, implementing, and assessing student response system (SRS) use in the classroom. Research indicates that SRS technology is effective in achieving desired outcomes in higher education settings. Studies indicate that effective SRS use promotes greater achievement of learning outcomes, increased student attention, improved class participation, and active engagement. The model offered in this article is based on best practices described in the literature and several years of SRS use in a traditional higher education classroom setting. Student feedback indicates increased class participation and engagement with SRS technology. Teacher feedback indicates opportunities for contingent teaching. The model described in this article provides a process to assist teachers in the successful selection, implementation, and assessment of SRS technology in the classroom.

  7. Entrepreneurial Women in Radiology: Role Models of Success.

    Science.gov (United States)

    Anzai, Yoshimi; Meltzer, Carolyn C; DeStigter, Kristen K; Destounis, Stamatia; Pawley, Barbara K; Oates, M Elizabeth

    2016-11-01

    Radiology is undeniably male dominated. Alongside surgery and orthopedic surgery, academic radiology ranks near the bottom in having the lowest proportion of full-time female faculty members. Despite many efforts to recruit talented women, the pipeline entering the radiologic disciplines continues to flow at a trickle. One factor is the relative lack of role models for female medical students. Entrepreneurial women in radiology can lead the field with their innovation and creativity, courage, and commitment. In this article, the authors highlight two entrepreneurial female radiologists who shared their success stories at the American Association for Women Radiologists' session at the 2015 ACR annual meeting. Their successes underscore the potential for such women to serve as role models to female medical students and even college undergraduates. Despite the gender gap in radiology, the field has yielded some exceptional women who can take on challenges, overcome barriers and assume risks, create strategies and processes to operationalize their visions, secure funding, and expand their enterprises to make sustainable impacts both at home and abroad. As we move toward more patient- and family-centered care models and become increasingly visible to diverse populations, there is no better time for female leaders in radiology to inspire the next generation to join our essential and rewarding specialty. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  8. Improving student success using predictive models and data visualisations

    Directory of Open Access Journals (Sweden)

    Hanan Ayad

    2012-08-01

    Full Text Available The need to educate a competitive workforce is a global problem. In the US, for example, despite billions of dollars spent to improve the educational system, approximately 35% of students never finish high school. The drop rate among some demographic groups is as high as 50–60%. At the college level in the US only 30% of students graduate from 2-year colleges in 3 years or less and approximately 50% graduate from 4-year colleges in 5 years or less. A basic challenge in delivering global education, therefore, is improving student success. By student success we mean improving retention, completion and graduation rates. In this paper we describe a Student Success System (S3 that provides a holistic, analytical view of student academic progress.1 The core of S3 is a flexible predictive modelling engine that uses machine intelligence and statistical techniques to identify at-risk students pre-emptively. S3 also provides a set of advanced data visualisations for reaching diagnostic insights and a case management tool for managing interventions. S3's open modular architecture will also allow integration and plug-ins with both open and proprietary software. Powered by learning analytics, S3 is intended as an end-to-end solution for identifying at-risk students, understanding why they are at risk, designing interventions to mitigate that risk and finally closing the feedback look by tracking the efficacy of the applied intervention.

  9. 3D-modeling of the spine using EOS imaging system: Inter-reader reproducibility and reliability.

    Science.gov (United States)

    Rehm, Johannes; Germann, Thomas; Akbar, Michael; Pepke, Wojciech; Kauczor, Hans-Ulrich; Weber, Marc-André; Spira, Daniel

    2017-01-01

    To retrospectively assess the interreader reproducibility and reliability of EOS 3D full spine reconstructions in patients with adolescent idiopathic scoliosis (AIS). 73 patients with mean age of 17 years and a moderate AIS (median Cobb Angle 18.2°) obtained low-dose standing biplanar radiographs with EOS. Two independent readers performed "full spine" 3D reconstructions of the spine with the "full-spine" method adjusting the bone contour of every thoracic and lumbar vertebra (Th1-L5). Interreader reproducibility was assessed regarding rotation of every single vertebra in the coronal (i.e. frontal), sagittal (i.e. lateral), and axial plane, T1/T12 kyphosis, T4/T12 kyphosis, L1/L5 lordosis, L1/S1 lordosis and pelvic parameters. Radiation exposure, scan-time and 3D reconstruction time were recorded. Interclass correlation (ICC) ranged between 0.83 and 0.98 for frontal vertebral rotation, between 0.94 and 0.99 for lateral vertebral rotation and between 0.51 and 0.88 for axial vertebral rotation. ICC was 0.92 for T1/T12 kyphosis, 0.95 for T4/T12 kyphosis, 0.90 for L1/L5 lordosis, 0.85 for L1/S1 lordosis, 0.97 for pelvic incidence, 0.96 for sacral slope, 0.98 for sagittal pelvic tilt and 0.94 for lateral pelvic tilt. The mean time for reconstruction was 14.9 minutes (reader 1: 14.6 minutes, reader 2: 15.2 minutes, p3D angle measurement of vertebral rotation proved to be reliable and was performed in an acceptable reconstruction time. Interreader reproducibility of axial rotation was limited to some degree in the upper and middle thoracic spine due the obtuse angulation of the pedicles and the processi spinosi in the frontal view somewhat complicating their delineation.

  10. Developing entrepreneurial competencies for successful business model canvas

    Science.gov (United States)

    Sundah, D. I. E.; Langi, C.; Maramis, D. R. S.; Tawalujan, L. dan

    2018-01-01

    We explore the competencies of entrepreneurship that contribute to business model canvas. This research conducted at smoked fish industries in Province of North Sulawesi, Indonesia. This research used a mixed method which integrating both quantitative and qualitative approaches in a sequential design. The technique of snowball sampling and questionnaire has been used in collecting data from 44 entrepreneurs. Structural equation modeling with SmartPLS application program has been used in analyzing this data to determine the effect of entrepreneurial competencies on business model canvas. We also investigate 3 entrepreneurs who conducted smoked fish business and analyzed their business by using business model canvas. Focus Group Discussion is used in collecting data from 2 groups of entrepreneurs from 2 different locations. The empirical results show that entrepreneurial competencies which consists of managerial competencies, technical competencies, marketing competencies, financial competencies, human relations competencies, and the specific working attitude of entrepreneur has a positive and significantly effect on business model canvas. Additionally, the empirical cases and discussion with 2 groups of entrepreneurs support the quantitative result and it found that human relations competencies have greater influence in achieving successful business model canvas.

  11. Dynamic contrast-enhanced computed tomography in metastatic nasopharyngeal carcinoma: reproducibility analysis and observer variability of the distributed parameter model.

    Science.gov (United States)

    Ng, Quan-Sing; Thng, Choon Hua; Lim, Wan Teck; Hartono, Septian; Thian, Yee Liang; Lee, Puor Sherng; Tan, Daniel Shao-Weng; Tan, Eng Huat; Koh, Tong San

    2012-01-01

    To determine the reproducibility and observer variability of distributed parameter analysis of dynamic contrast-enhanced computed tomography (DCE-CT) data in metastatic nasopharyngeal carcinoma, and to compare 2 approaches of region-of-interest (ROI) analyses. Following ethical approval and informed consent, 17 patients with nasopharyngeal carcinoma underwent paired DCE-CT examinations on a 64-detector scanner, measuring tumor blood flow (F, mL/100 mL/min), permeability surface area product (PS, mL/100 mL/min), fractional intravascular blood volume (v1, mL/100 mL), and fractional extracellular-extravascular volume (v2, mL/100 mL). Tumor parameters were derived by fitting (i) the ROI-averaged concentration-time curve, and (ii) the median value of parameters from voxel-level concentration-time curves. Measurement reproducibility and inter- and intraobserver variability were estimated using Bland-Altman statistics. Mean F, PS, v1, and v2 are 44.9, 20.4, 7.1, and 34.1 for ROI analysis, and 49.0, 18.7, 6.7, and 34.0 for voxel analysis, respectively. Within-subject coefficients of variation are 38.8%, 49.5%, 54.2%, and 35.9% for ROI analysis, and 15.0%, 35.1%, 33.0%, and 21.0% for voxel analysis, respectively. Repeatability coefficients are 48.2, 28.0, 10.7, and 33.9 for ROI analysis, and 20.3, 18.2, 6.1 and 19.8 for voxel analysis, respectively. Intra- and interobserver correlation coefficient ranged from 0.94 to 0.97 and 0.90 to 0.95 for voxel analysis, and 0.73 to 0.87 and 0.72 to 0.94 for ROI analysis, respectively. Measurements of F and v2 appear more reproducible than PS and v1. Voxel-level analysis improves both reproducibility and observer variability compared with ROI-averaged analysis and may retain information about tumor spatial heterogeneity.

  12. Measurement of cerebral blood flow by intravenous xenon-133 technique and a mobile system. Reproducibility using the Obrist model compared to total curve analysis

    DEFF Research Database (Denmark)

    Schroeder, T; Holstein, P; Lassen, N A

    1986-01-01

    was considerably more reproducible than CBF level. Using a single detector instead of five regional values averaged as the hemispheric flow increased standard deviation of CBF level by 10-20%, while the variation in asymmetry was doubled. In optimal measuring conditions the two models revealed no significant...... differences, but in low flow situations the artifact model yielded significantly more stable results. The present apparatus, equipped with 3-5 detectors covering each hemisphere, offers the opportunity of performing serial CBF measurements in situations not otherwise feasible.......The recent development of a mobile 10 detector unit, using i.v. Xenon-133 technique, has made it possible to perform repeated bedside measurements of cerebral blood flow (CBF). Test-retest studies were carried out in 38 atherosclerotic subjects, in order to evaluate the reproducibility of CBF level...

  13. Habitat fragmentation and reproductive success: a structural equation modelling approach.

    Science.gov (United States)

    Le Tortorec, Eric; Helle, Samuli; Käyhkö, Niina; Suorsa, Petri; Huhta, Esa; Hakkarainen, Harri

    2013-09-01

    1. There is great interest on the effects of habitat fragmentation, whereby habitat is lost and the spatial configuration of remaining habitat patches is altered, on individual breeding performance. However, we still lack consensus of how this important process affects reproductive success, and whether its effects are mainly due to reduced fecundity or nestling survival. 2. The main reason for this may be the way that habitat fragmentation has been previously modelled. Studies have treated habitat loss and altered spatial configuration as two independent processes instead of as one hierarchical and interdependent process, and therefore have not been able to consider the relative direct and indirect effects of habitat loss and altered spatial configuration. 3. We investigated how habitat (i.e. old forest) fragmentation, caused by intense forest harvesting at the territory and landscape scales, is associated with the number of fledged offspring of an area-sensitive passerine, the Eurasian treecreeper (Certhia familiaris). We used structural equation modelling (SEM) to examine the complex hierarchical associations between habitat loss and altered spatial configuration on the number of fledged offspring, by controlling for individual condition and weather conditions during incubation. 4. Against generally held expectations, treecreeper reproductive success did not show a significant association with habitat fragmentation measured at the territory scale. Instead, our analyses suggested that an increasing amount of habitat at the landscape scale caused a significant increase in nest predation rates, leading to reduced reproductive success. This effect operated directly on nest predation rates, instead of acting indirectly through altered spatial configuration. 5. Because habitat amount and configuration are inherently strongly collinear, particularly when multiple scales are considered, our study demonstrates the usefulness of a SEM approach for hierarchical partitioning

  14. Reproducibility study of [{sup 18}F]FPP(RGD){sub 2} uptake in murine models of human tumor xenografts

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Edwin; Liu, Shuangdong; Chin, Frederick; Cheng, Zhen [Stanford University, Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford, CA (United States); Gowrishankar, Gayatri; Yaghoubi, Shahriar [Stanford University, Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford, CA (United States); Stanford University, Molecular Imaging Program at Stanford, Department of Bioengineering, School of Medicine, Stanford, CA (United States); Wedgeworth, James Patrick [Stanford University, Molecular Imaging Program at Stanford, Department of Bioengineering, School of Medicine, Stanford, CA (United States); Berndorff, Dietmar; Gekeler, Volker [Bayer Schering Pharma AG, Global Drug Discovery, Berlin (Germany); Gambhir, Sanjiv S. [Stanford University, Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford, CA (United States); Stanford University, Molecular Imaging Program at Stanford, Department of Bioengineering, School of Medicine, Stanford, CA (United States); Canary Center at Stanford for Cancer Early Detection, Nuclear Medicine, Departments of Radiology and Bioengineering, Molecular Imaging Program at Stanford, Stanford, CA (United States)

    2011-04-15

    An {sup 18}F-labeled PEGylated arginine-glycine-aspartic acid (RGD) dimer [{sup 18}F]FPP(RGD){sub 2} has been used to image tumor {alpha}{sub v}{beta}{sub 3} integrin levels in preclinical and clinical studies. Serial positron emission tomography (PET) studies may be useful for monitoring antiangiogenic therapy response or for drug screening; however, the reproducibility of serial scans has not been determined for this PET probe. The purpose of this study was to determine the reproducibility of the integrin {alpha}{sub v}{beta}{sub 3}-targeted PET probe, [{sup 18}F ]FPP(RGD){sub 2} using small animal PET. Human HCT116 colon cancer xenografts were implanted into nude mice (n = 12) in the breast and scapular region and grown to mean diameters of 5-15 mm for approximately 2.5 weeks. A 3-min acquisition was performed on a small animal PET scanner approximately 1 h after administration of [{sup 18}F]FPP(RGD){sub 2} (1.9-3.8 MBq, 50-100 {mu}Ci) via the tail vein. A second small animal PET scan was performed approximately 6 h later after reinjection of the probe to assess for reproducibility. Images were analyzed by drawing an ellipsoidal region of interest (ROI) around the tumor xenograft activity. Percentage injected dose per gram (%ID/g) values were calculated from the mean or maximum activity in the ROIs. Coefficients of variation and differences in %ID/g values between studies from the same day were calculated to determine the reproducibility. The coefficient of variation (mean {+-}SD) for %ID{sub mean}/g and %ID{sub max}/g values between [{sup 18}F]FPP(RGD){sub 2} small animal PET scans performed 6 h apart on the same day were 11.1 {+-} 7.6% and 10.4 {+-} 9.3%, respectively. The corresponding differences in %ID{sub mean}/g and %ID{sub max}/g values between scans were -0.025 {+-} 0.067 and -0.039 {+-} 0.426. Immunofluorescence studies revealed a direct relationship between extent of {alpha}{sub {nu}}{beta}{sub 3} integrin expression in tumors and tumor vasculature

  15. [Reproducing and evaluating a rabbit model of multiple organ dysfunction syndrome after cardiopulmonary resuscitation resulted from asphyxia].

    Science.gov (United States)

    Zhang, Dong; Li, Nan; Chen, Ying; Wang, Yu-shan

    2013-02-01

    To evaluate the reproduction of a model of post resuscitation multiple organ dysfunction syndrome (PR-MODS) after cardiac arrest (CA) in rabbit, in order to provide new methods for post-CA treatment. Thirty-five rabbits were randomly divided into three groups, the sham group (n=5), the 7-minute asphyxia group (n=15), and the 8-minute asphyxia group (n=15). The asphyxia CA model was reproduced with tracheal occlusion. After cardiopulmonary resuscitation (CPR), the ratio of recovery of spontaneous circulation (ROSC), the mortality at different time points and the incidence of systemic inflammatory response syndrome (SIRS) were observed in two asphyxia groups. Creatine kinase isoenzyme (CK-MB), alanine aminotransferase (ALT), creatinine (Cr), glucose (Glu) and arterial partial pressure of oxygen (PaO2) levels in blood were measured in the two asphyxia groups before CPR and 12, 24 and 48 hours after ROSC. The survived rabbits were euthanized at 48 hours after ROSC, and heart, brain, lung, kidney, liver, and intestine were harvested for pathological examination using light microscope. PR-MODS after CA was defined based on the function of main organs and their pathological changes. (1) The incidence of ROSC was 100.0% in 7-minute asphyxia group and 86.7% in 8-minute asphyxia group respectively (P>0.05). The 6-hour mortality in 8-minute asphyxia group was significantly higher than that in 7-minute asphyxia group (46.7% vs. 6.7%, P0.05). (2) There was a variety of organ dysfunctions in survived rabbits after ROSC, including chemosis, respiratory distress, hypotension, abdominal distension, weakened or disappearance of bowel peristalsis and oliguria. (3) There was no SIRS or associated changes in major organ function in the sham group. SIRS was observed at 12 - 24 hours after ROSC in the two asphyxia groups. CK-MB was increased significantly at 12 hours after ROSC compared with that before asphyxia (7-minute asphyxia group: 786.88±211.84 U/L vs. 468.20±149.45 U/L, 8

  16. Development and reproducibility evaluation of a Monte Carlo-based standard LINAC model for quality assurance of multi-institutional clinical trials.

    Science.gov (United States)

    Usmani, Muhammad Nauman; Takegawa, Hideki; Takashina, Masaaki; Numasaki, Hodaka; Suga, Masaki; Anetai, Yusuke; Kurosu, Keita; Koizumi, Masahiko; Teshima, Teruki

    2014-11-01

    Technical developments in radiotherapy (RT) have created a need for systematic quality assurance (QA) to ensure that clinical institutions deliver prescribed radiation doses consistent with the requirements of clinical protocols. For QA, an ideal dose verification system should be independent of the treatment-planning system (TPS). This paper describes the development and reproducibility evaluation of a Monte Carlo (MC)-based standard LINAC model as a preliminary requirement for independent verification of dose distributions. The BEAMnrc MC code is used for characterization of the 6-, 10- and 15-MV photon beams for a wide range of field sizes. The modeling of the LINAC head components is based on the specifications provided by the manufacturer. MC dose distributions are tuned to match Varian Golden Beam Data (GBD). For reproducibility evaluation, calculated beam data is compared with beam data measured at individual institutions. For all energies and field sizes, the MC and GBD agreed to within 1.0% for percentage depth doses (PDDs), 1.5% for beam profiles and 1.2% for total scatter factors (Scps.). Reproducibility evaluation showed that the maximum average local differences were 1.3% and 2.5% for PDDs and beam profiles, respectively. MC and institutions' mean Scps agreed to within 2.0%. An MC-based standard LINAC model developed to independently verify dose distributions for QA of multi-institutional clinical trials and routine clinical practice has proven to be highly accurate and reproducible and can thus help ensure that prescribed doses delivered are consistent with the requirements of clinical protocols. © The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.

  17. New models for success emerge for US natural gas industry

    International Nuclear Information System (INIS)

    Addy, W.M.; Hutchinson, R.A.

    1994-01-01

    Very few companies in the US natural gas industry are confident in their ability to compete effectively in the brave new world of deregulation. Boston Consulting Group recently conducted an internal study to help the industry think about its future and identify models for success in this new environment. The authors examined the historical performance of 800 companies using several shareholder-value indicators, including cash-flow returns on investment, a measure of cash returns on cash invested that correlates closely to share price. Based on that review and discussions with investment managers and industry analysts, the authors were able to focus on a handful of companies that actually have thrived and created value against the difficult landscape of the past decade. Interviews with their senior executives provided important strategic and operational insights

  18. Spatial succession modeling of biological communities: a multi-model approach.

    Science.gov (United States)

    Zhang, WenJun; Wei, Wu

    2009-11-01

    Strong spatial correlation may exist in the spatial succession of biological communities, and the spatial succession can be mathematically described. It was confirmed by our study on spatial succession of both plant and arthropod communities along a linear transect of natural grassland. Both auto-correlation and cross-correlation analyses revealed that the succession of plant and arthropod communities exhibited a significant spatial correlation, and the spatial correlation for plant community succession was stronger than arthropod community succession. Theoretically it should be reasonable to infer a site's community composition from the last site in the linear transect. An artificial neural network for state space modeling (ANNSSM) was developed in present study. An algorithm (i.e., Importance Detection Method (IDM)) for determining the relative importance of input variables was proposed. The relative importance for plant families Gramineae, Compositae and Leguminosae, and arthropod orders Homoptera, Diptera and Orthoptera, were detected and analyzed using IDM. ANNSSM performed better than multivariate linear regression and ordinary differential equation, while ordinary differential equation exhibited the worst performance in the simulation and prediction of spatial succession of biological communities. A state transition probability model (STPM) was proposed to simulate the state transition process of biological communities. STPM performed better than multinomial logistic regression in the state transition modeling. We suggested a novel multi-model framework, i.e., the joint use of ANNSSM and STPM, to predict the spatial succession of biological communities. In this framework, ANNSSM and STPM can be separately used to simulate the continuous and discrete dynamics.

  19. Pangea breakup and northward drift of the Indian subcontinent reproduced by a numerical model of mantle convection.

    Science.gov (United States)

    Yoshida, Masaki; Hamano, Yozo

    2015-02-12

    Since around 200 Ma, the most notable event in the process of the breakup of Pangea has been the high speed (up to 20 cm yr(-1)) of the northward drift of the Indian subcontinent. Our numerical simulations of 3-D spherical mantle convection approximately reproduced the process of continental drift from the breakup of Pangea at 200 Ma to the present-day continental distribution. These simulations revealed that a major factor in the northward drift of the Indian subcontinent was the large-scale cold mantle downwelling that developed spontaneously in the North Tethys Ocean, attributed to the overall shape of Pangea. The strong lateral mantle flow caused by the high-temperature anomaly beneath Pangea, due to the thermal insulation effect, enhanced the acceleration of the Indian subcontinent during the early stage of the Pangea breakup. The large-scale hot upwelling plumes from the lower mantle, initially located under Africa, might have contributed to the formation of the large-scale cold mantle downwelling in the North Tethys Ocean.

  20. Three-dimensional surgical modelling with an open-source software protocol: study of precision and reproducibility in mandibular reconstruction with the fibula free flap.

    Science.gov (United States)

    Ganry, L; Quilichini, J; Bandini, C M; Leyder, P; Hersant, B; Meningaud, J P

    2017-08-01

    Very few surgical teams currently use totally independent and free solutions to perform three-dimensional (3D) surgical modelling for osseous free flaps in reconstructive surgery. This study assessed the precision and technical reproducibility of a 3D surgical modelling protocol using free open-source software in mandibular reconstruction with fibula free flaps and surgical guides. Precision was assessed through comparisons of the 3D surgical guide to the sterilized 3D-printed guide, determining accuracy to the millimetre level. Reproducibility was assessed in three surgical cases by volumetric comparison to the millimetre level. For the 3D surgical modelling, a difference of less than 0.1mm was observed. Almost no deformations (free flap modelling was between 0.1mm and 0.4mm, and the average precision of the complete reconstructed mandible was less than 1mm. The open-source software protocol demonstrated high accuracy without complications. However, the precision of the surgical case depends on the surgeon's 3D surgical modelling. Therefore, surgeons need training on the use of this protocol before applying it to surgical cases; this constitutes a limitation. Further studies should address the transfer of expertise. Copyright © 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  1. The Proximal Medial Sural Nerve Biopsy Model: A Standardised and Reproducible Baseline Clinical Model for the Translational Evaluation of Bioengineered Nerve Guides

    Directory of Open Access Journals (Sweden)

    Ahmet Bozkurt

    2014-01-01

    Full Text Available Autologous nerve transplantation (ANT is the clinical gold standard for the reconstruction of peripheral nerve defects. A large number of bioengineered nerve guides have been tested under laboratory conditions as an alternative to the ANT. The step from experimental studies to the implementation of the device in the clinical setting is often substantial and the outcome is unpredictable. This is mainly linked to the heterogeneity of clinical peripheral nerve injuries, which is very different from standardized animal studies. In search of a reproducible human model for the implantation of bioengineered nerve guides, we propose the reconstruction of sural nerve defects after routine nerve biopsy as a first or baseline study. Our concept uses the medial sural nerve of patients undergoing diagnostic nerve biopsy (≥2 cm. The biopsy-induced nerve gap was immediately reconstructed by implantation of the novel microstructured nerve guide, Neuromaix, as part of an ongoing first-in-human study. Here we present (i a detailed list of inclusion and exclusion criteria, (ii a detailed description of the surgical procedure, and (iii a follow-up concept with multimodal sensory evaluation techniques. The proximal medial sural nerve biopsy model can serve as a preliminarynature of the injuries or baseline nerve lesion model. In a subsequent step, newly developed nerve guides could be tested in more unpredictable and challenging clinical peripheral nerve lesions (e.g., following trauma which have reduced comparability due to the different nature of the injuries (e.g., site of injury and length of nerve gap.

  2. Business Models for Successfully Maintaining Games for Health.

    Science.gov (United States)

    Baranowski, Moderator Tom; Isaac, Participants Fikry; Ashford, Chris; Goldman, Ron; Lenihan, David J; Poole, Brent; Buday, Richard; van Rijswijk, Jurriaan

    2013-04-01

    Videogames for health provide innovative, exciting, and possibly highly effective new media for helping players change their behaviors or otherwise benefit their health. Getting the right videogames into the hands of players who can benefit most in a way that pays for the continued innovation and creation of such games is a current challenge. Entertainment videogame companies, which create games primarily to enhance players' enjoyment, have used the general business marketplace (e.g., online stores, walk-in stores, app stores) to deliver their products directly to consumers and earn enough capital to invest in making new products. No one believes, however, that enough kids or adults would use the general business marketplace to purchase games for health in sufficient volume to provide the down payment for the innovation and creation of new games for health. A successful business model is critical to the financial future of games for health. We asked members of our Editorial Board who are in health-related companies (Fikry Isaac, MD, MPH), in several game development companies (Chris Ashford, Ron Goldman, David J. Lenihan, Brent Poole, and Richard Buday, FAIA), and the head of the Games for Health Europe Foundation (Jurriaan van Rijswijk, MSc) to address questions in a roundtable about the current and possible future business models for games for health.

  3. Reproducibility in Seismic Imaging

    Directory of Open Access Journals (Sweden)

    González-Verdejo O.

    2012-04-01

    Full Text Available Within the field of exploration seismology, there is interest at national level of integrating reproducibility in applied, educational and research activities related to seismic processing and imaging. This reproducibility implies the description and organization of the elements involved in numerical experiments. Thus, a researcher, teacher or student can study, verify, repeat, and modify them independently. In this work, we document and adapt reproducibility in seismic processing and imaging to spread this concept and its benefits, and to encourage the use of open source software in this area within our academic and professional environment. We present an enhanced seismic imaging example, of interest in both academic and professional environments, using Mexican seismic data. As a result of this research, we prove that it is possible to assimilate, adapt and transfer technology at low cost, using open source software and following a reproducible research scheme.

  4. Development of an Electronic Portfolio System Success Model: An Information Systems Approach

    Science.gov (United States)

    Balaban, Igor; Mu, Enrique; Divjak, Blazenka

    2013-01-01

    This research has two main goals: to develop an instrument for assessing Electronic Portfolio (ePortfolio) success and to build a corresponding ePortfolio success model using DeLone and McLean's information systems success model as the theoretical framework. For this purpose, we developed an ePortfolio success measurement instrument and structural…

  5. The Influence of Quality on E-Commerce Success: An Empirical Application of the Delone and Mclean IS Success Model

    OpenAIRE

    Ultan Sharkey; Murray Scott; Thomas Acton

    2010-01-01

    This research addresses difficulties in measuring e-commerce success by implementing the DeLone and McLean (D&M) model of IS success (1992, 2003) in an e-commerce environment. This research considers the influence of quality on e-commerce success by measuring the information quality and system quality attributes of an e-commerce system and the intention to use, user satisfaction and intention to transact from a sample of respondents. This research provides an empirical e-commerce application ...

  6. On the successful use of a simplified model to simulate the succession of toxic cyanobacteria in a hypereutrophic reservoir with a highly fluctuating water level.

    Science.gov (United States)

    Fadel, Ali; Lemaire, Bruno J; Vinçon-Leite, Brigitte; Atoui, Ali; Slim, Kamal; Tassin, Bruno

    2017-09-01

    Many freshwater bodies worldwide that suffer from harmful algal blooms would benefit for their management from a simple ecological model that requires few field data, e.g. for early warning systems. Beyond a certain degree, adding processes to ecological models can reduce model predictive capabilities. In this work, we assess whether a simple ecological model without nutrients is able to describe the succession of cyanobacterial blooms of different species in a hypereutrophic reservoir and help understand the factors that determine these blooms. In our study site, Karaoun Reservoir, Lebanon, cyanobacteria Aphanizomenon ovalisporum and Microcystis aeruginosa alternatively bloom. A simple configuration of the model DYRESM-CAEDYM was used; both cyanobacteria were simulated, with constant vertical migration velocity for A. ovalisporum, with vertical migration velocity dependent on light for M. aeruginosa and with growth limited by light and temperature and not by nutrients for both species. The model was calibrated on two successive years with contrasted bloom patterns and high variations in water level. It was able to reproduce the measurements; it showed a good performance for the water level (root-mean-square error (RMSE) lower than 1 m, annual variation of 25 m), water temperature profiles (RMSE of 0.22-1.41 °C, range 13-28 °C) and cyanobacteria biomass (RMSE of 1-57 μg Chl a L -1 , range 0-206 μg Chl a L -1 ). The model also helped understand the succession of blooms in both years. The model results suggest that the higher growth rate of M. aeruginosa during favourable temperature and light conditions allowed it to outgrow A. ovalisporum. Our results show that simple model configurations can be sufficient not only for theoretical works when few major processes can be identified but also for operational applications. This approach could be transposed on other hypereutrophic lakes and reservoirs to describe the competition between dominant phytoplankton

  7. Accuracy and reproducibility of voxel based superimposition of cone beam computed tomography models on the anterior cranial base and the zygomatic arches.

    Science.gov (United States)

    Nada, Rania M; Maal, Thomas J J; Breuning, K Hero; Bergé, Stefaan J; Mostafa, Yehya A; Kuijpers-Jagtman, Anne Marie

    2011-02-09

    Superimposition of serial Cone Beam Computed Tomography (CBCT) scans has become a valuable tool for three dimensional (3D) assessment of treatment effects and stability. Voxel based image registration is a newly developed semi-automated technique for superimposition and comparison of two CBCT scans. The accuracy and reproducibility of CBCT superimposition on the anterior cranial base or the zygomatic arches using voxel based image registration was tested in this study. 16 pairs of 3D CBCT models were constructed from pre and post treatment CBCT scans of 16 adult dysgnathic patients. Each pair was registered on the anterior cranial base three times and on the left zygomatic arch twice. Following each superimposition, the mean absolute distances between the 2 models were calculated at 4 regions: anterior cranial base, forehead, left and right zygomatic arches. The mean distances between the models ranged from 0.2 to 0.37 mm (SD 0.08-0.16) for the anterior cranial base registration and from 0.2 to 0.45 mm (SD 0.09-0.27) for the zygomatic arch registration. The mean differences between the two registration zones ranged between 0.12 to 0.19 mm at the 4 regions. Voxel based image registration on both zones could be considered as an accurate and a reproducible method for CBCT superimposition. The left zygomatic arch could be used as a stable structure for the superimposition of smaller field of view CBCT scans where the anterior cranial base is not visible.

  8. Assessment of a numerical model to reproduce event‐scale erosion and deposition distributions in a braided river

    Science.gov (United States)

    Measures, R.; Hicks, D. M.; Brasington, J.

    2016-01-01

    Abstract Numerical morphological modeling of braided rivers, using a physics‐based approach, is increasingly used as a technique to explore controls on river pattern and, from an applied perspective, to simulate the impact of channel modifications. This paper assesses a depth‐averaged nonuniform sediment model (Delft3D) to predict the morphodynamics of a 2.5 km long reach of the braided Rees River, New Zealand, during a single high‐flow event. Evaluation of model performance primarily focused upon using high‐resolution Digital Elevation Models (DEMs) of Difference, derived from a fusion of terrestrial laser scanning and optical empirical bathymetric mapping, to compare observed and predicted patterns of erosion and deposition and reach‐scale sediment budgets. For the calibrated model, this was supplemented with planform metrics (e.g., braiding intensity). Extensive sensitivity analysis of model functions and parameters was executed, including consideration of numerical scheme for bed load component calculations, hydraulics, bed composition, bed load transport and bed slope effects, bank erosion, and frequency of calculations. Total predicted volumes of erosion and deposition corresponded well to those observed. The difference between predicted and observed volumes of erosion was less than the factor of two that characterizes the accuracy of the Gaeuman et al. bed load transport formula. Grain size distributions were best represented using two φ intervals. For unsteady flows, results were sensitive to the morphological time scale factor. The approach of comparing observed and predicted morphological sediment budgets shows the value of using natural experiment data sets for model testing. Sensitivity results are transferable to guide Delft3D applications to other rivers. PMID:27708477

  9. Skills of General Circulation and Earth System Models in reproducing streamflow to the ocean: the case of Congo river

    Science.gov (United States)

    Santini, M.; Caporaso, L.

    2017-12-01

    Although the importance of water resources in the context of climate change, it is still difficult to correctly simulate the freshwater cycle over the land via General Circulation and Earth System Models (GCMs and ESMs). Existing efforts from the Climate Model Intercomparison Project 5 (CMIP5) were mainly devoted to the validation of atmospheric variables like temperature and precipitation, with low attention to discharge.Here we investigate the present-day performances of GCMs and ESMs participating to CMIP5 in simulating the discharge of the river Congo to the sea thanks to: i) the long-term availability of discharge data for the Kinshasa hydrological station representative of more than 95% of the water flowing in the whole catchment; and ii) the River's still low influence by human intervention, which enables comparison with the (mostly) natural streamflow simulated within CMIP5.Our findings suggest how most of models appear overestimating the streamflow in terms of seasonal cycle, especially in the late winter and spring, while overestimation and variability across models are lower in late summer. Weighted ensemble means are also calculated, based on simulations' performances given by several metrics, showing some improvements of results.Although simulated inter-monthly and inter-annual percent anomalies do not appear significantly different from those in observed data, when translated into well consolidated indicators of drought attributes (frequency, magnitude, timing, duration), usually adopted for more immediate communication to stakeholders and decision makers, such anomalies can be misleading.These inconsistencies produce incorrect assessments towards water management planning and infrastructures (e.g. dams or irrigated areas), especially if models are used instead of measurements, as in case of ungauged basins or for basins with insufficient data, as well as when relying on models for future estimates without a preliminary quantification of model biases.

  10. Assessment of a numerical model to reproduce event-scale erosion and deposition distributions in a braided river

    Science.gov (United States)

    Williams, R. D.; Measures, R.; Hicks, D. M.; Brasington, J.

    2016-08-01

    Numerical morphological modeling of braided rivers, using a physics-based approach, is increasingly used as a technique to explore controls on river pattern and, from an applied perspective, to simulate the impact of channel modifications. This paper assesses a depth-averaged nonuniform sediment model (Delft3D) to predict the morphodynamics of a 2.5 km long reach of the braided Rees River, New Zealand, during a single high-flow event. Evaluation of model performance primarily focused upon using high-resolution Digital Elevation Models (DEMs) of Difference, derived from a fusion of terrestrial laser scanning and optical empirical bathymetric mapping, to compare observed and predicted patterns of erosion and deposition and reach-scale sediment budgets. For the calibrated model, this was supplemented with planform metrics (e.g., braiding intensity). Extensive sensitivity analysis of model functions and parameters was executed, including consideration of numerical scheme for bed load component calculations, hydraulics, bed composition, bed load transport and bed slope effects, bank erosion, and frequency of calculations. Total predicted volumes of erosion and deposition corresponded well to those observed. The difference between predicted and observed volumes of erosion was less than the factor of two that characterizes the accuracy of the Gaeuman et al. bed load transport formula. Grain size distributions were best represented using two φ intervals. For unsteady flows, results were sensitive to the morphological time scale factor. The approach of comparing observed and predicted morphological sediment budgets shows the value of using natural experiment data sets for model testing. Sensitivity results are transferable to guide Delft3D applications to other rivers.

  11. Social Media Success for Academic Knowledge Sharing in Indonesia (Conceptual Model Development)

    Science.gov (United States)

    Assegaff, Setiawan

    2017-04-01

    The aim of this study is to investigate how success is the social media as a tool for knowledge sharing among scholars in Indonesia. To evaluate the success of social media we develop a model base on Delone and McLeane IS Success Model. In this article, we would like discuss the process of developing the research model. In developing the model, we conduct literature review from knowledge management, social media and IS Success Model area from previous study. This study resulted in the social success model for academic knowledge sharing in Indonesia.

  12. Repeatability and Reproducibility of Corneal Biometric Measurements Using the Visante Omni and a Rabbit Experimental Model of Post-Surgical Corneal Ectasia

    Science.gov (United States)

    Liu, Yu-Chi; Konstantopoulos, Aris; Riau, Andri K.; Bhayani, Raj; Lwin, Nyein C.; Teo, Ericia Pei Wen; Yam, Gary Hin Fai; Mehta, Jodhbir S.

    2015-01-01

    Purpose: To investigate the repeatability and reproducibility of the Visante Omni topography in obtaining topography measurements of rabbit corneas and to develop a post-surgical model of corneal ectasia. Methods: Eight rabbits were used to study the repeatability and reproducibility by assessing the intra- and interobserver bias and limits of agreement. Another nine rabbits underwent different diopters (D) of laser in situ keratosmileusis (LASIK) were used for the development of ectasia model. All eyes were examined with the Visante Omni, and corneal ultrastructure were evaluated with transmission electron microscopy (TEM). Results: There was no significant intra- or interobserver difference for mean steep and flat keratometry (K) values of simulated K, anterior, and posterior elevation measurements. Eyes underwent −5 D LASIK had a significant increase in mean amplitude of astigmatism and posterior surface elevation with time (P for trend corneal ectasia that was gradual in development and simulated the human condition. Translational Relevance: The results provide the foundations for the future evaluation of novel treatment modalities for post-surgical ectasia and keratoconus. PMID:25938004

  13. A Reliable and Reproducible Model for Assessing the Effect of Different Concentrations of α-Solanine on Rat Bone Marrow Mesenchymal Stem Cells

    Directory of Open Access Journals (Sweden)

    Adriana Ordóñez-Vásquez

    2017-01-01

    Full Text Available Αlpha-solanine (α-solanine is a glycoalkaloid present in potato (Solanum tuberosum. It has been of particular interest because of its toxicity and potential teratogenic effects that include abnormalities of the central nervous system, such as exencephaly, encephalocele, and anophthalmia. Various types of cell culture have been used as experimental models to determine the effect of α-solanine on cell physiology. The morphological changes in the mesenchymal stem cell upon exposure to α-solanine have not been established. This study aimed to describe a reliable and reproducible model for assessing the structural changes induced by exposure of mouse bone marrow mesenchymal stem cells (MSCs to different concentrations of α-solanine for 24 h. The results demonstrate that nonlethal concentrations of α-solanine (2–6 μM changed the morphology of the cells, including an increase in the number of nucleoli, suggesting elevated protein synthesis, and the formation of spicules. In addition, treatment with α-solanine reduced the number of adherent cells and the formation of colonies in culture. Immunophenotypic characterization and staining of MSCs are proposed as a reproducible method that allows description of cells exposed to the glycoalkaloid, α-solanine.

  14. Africa's Great Green Wall Initiative: a model for restoration success

    Science.gov (United States)

    Berrahmouni, Nora; Sacande, Moctar

    2014-05-01

    The Great Green Wall for the Sahara and the Sahel Initiative was launched to address the increasing challenges of land degradation, desertification and drought, climate change, food insecurity and poverty in more than 20 countries. Restoration of agro-sylvo-pastoral landscapes and degraded lands is one of the priority interventions initiated, enabling the springing up of green nests of life. When complete, the Great Green Wall of Africa will reverse the seemingly unstoppable desertification and address the development of its drylands' inhabitant rural communities. Today's planting of modest seedlings will grow into vast mosaics of forest and agroforestry landscapes and grasslands, which will provide essential ecosystem goods and services, restore lost livelihoods and create new wealth. The ambition of reforestation efforts within this initiative - the like of which the world has never seen before - sounds like an impossible dream. However, learning from past mistakes and capitalising on current advancement in science and technology, it is a reality that is taking root. Following a successful restoration model that RBG Kew experts have devised, we are helping to mobilise, train and support communities in four border regions in Burkina Faso, Mali and Niger. In collaboration with FAO, the Millennium Seed Bank Partnership is using its unique expertise to ensure that seeds of environmentally well-adapted and economically useful local species are collected and planted in communal gardens and village agroforestry systems managed by the communities themselves. In our first year, an estimated total of 162,000 seedlings and 61 kg of seeds from 40 useful native species, including grasses for livestock, have been planted to cover 237 ha of farmer-managed land in 19 villages. The keen interest it has created has indicated that these figures will rise five-fold in the second year. These green bricks are the foundations of the living wall that will eventually reach across the

  15. Attempting to train a digital human model to reproduce human subject reach capabilities in an ejection seat aircraft

    NARCIS (Netherlands)

    Zehner, G.F.; Hudson, J.A.; Oudenhuijzen, A.

    2006-01-01

    From 1997 through 2002, the Air Force Research Lab and TNO Defence, Security and Safety (Business Unit Human Factors) were involved in a series of tests to quantify the accuracy of five Human Modeling Systems (HMSs) in determining accommodation limits of ejection seat aircraft. The results of these

  16. A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis.

    Science.gov (United States)

    Burrell-Saward, Hollie; Rodgers, Jean; Bradley, Barbara; Croft, Simon L; Ward, Theresa H

    2015-02-01

    To optimize the Trypanosoma brucei brucei GVR35 VSL-2 bioluminescent strain as an innovative drug evaluation model for late-stage human African trypanosomiasis. An IVIS® Lumina II imaging system was used to detect bioluminescent T. b. brucei GVR35 parasites in mice to evaluate parasite localization and disease progression. Drug treatment was assessed using qualitative bioluminescence imaging and real-time quantitative PCR (qPCR). We have shown that drug dose-response can be evaluated using bioluminescence imaging and confirmed quantification of tissue parasite load using qPCR. The model was also able to detect drug relapse earlier than the traditional blood film detection and even in the absence of any detectable peripheral parasites. We have developed and optimized a new, efficient method to evaluate novel anti-trypanosomal drugs in vivo and reduce the current 180 day drug relapse experiment to a 90 day model. The non-invasive in vivo imaging model reduces the time required to assess preclinical efficacy of new anti-trypanosomal drugs. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  17. Isokinetic eccentric exercise as a model to induce and reproduce pathophysiological alterations related to delayed onset muscle soreness

    DEFF Research Database (Denmark)

    Lund, Henrik; Vestergaard-Poulsen, P; Kanstrup, I.L.

    1998-01-01

    Physiological alterations following unaccustomed eccentric exercise in an isokinetic dynamometer of the right m. quadriceps until exhaustion were studied, in order to create a model in which the physiological responses to physiotherapy could be measured. In experiment I (exp. I), seven selected p...

  18. Developing a Collection of Composable Data Translation Software Units to Improve Efficiency and Reproducibility in Ecohydrologic Modeling Workflows

    Science.gov (United States)

    Olschanowsky, C.; Flores, A. N.; FitzGerald, K.; Masarik, M. T.; Rudisill, W. J.; Aguayo, M.

    2017-12-01

    Dynamic models of the spatiotemporal evolution of water, energy, and nutrient cycling are important tools to assess impacts of climate and other environmental changes on ecohydrologic systems. These models require spatiotemporally varying environmental forcings like precipitation, temperature, humidity, windspeed, and solar radiation. These input data originate from a variety of sources, including global and regional weather and climate models, global and regional reanalysis products, and geostatistically interpolated surface observations. Data translation measures, often subsetting in space and/or time and transforming and converting variable units, represent a seemingly mundane, but critical step in the application workflows. Translation steps can introduce errors, misrepresentations of data, slow execution time, and interrupt data provenance. We leverage a workflow that subsets a large regional dataset derived from the Weather Research and Forecasting (WRF) model and prepares inputs to the Parflow integrated hydrologic model to demonstrate the impact translation tool software quality on scientific workflow results and performance. We propose that such workflows will benefit from a community approved collection of data transformation components. The components should be self-contained composable units of code. This design pattern enables automated parallelization and software verification, improving performance and reliability. Ensuring that individual translation components are self-contained and target minute tasks increases reliability. The small code size of each component enables effective unit and regression testing. The components can be automatically composed for efficient execution. An efficient data translation framework should be written to minimize data movement. Composing components within a single streaming process reduces data movement. Each component will typically have a low arithmetic intensity, meaning that it requires about the same number of

  19. Evaluating the impacts of slope aspect on forest dynamic succession in Northwest China based on FAREAST model

    Science.gov (United States)

    Hu, Shanshan; Ma, Jianyong; Shugart, Herman H.; Yan, Xiaodong

    2018-03-01

    Mountain forests provide the main water resources and lumber for Northwest China. The understanding of the differences in forests growing among individual slope aspects in mountainous regions is of great significance to the wise management and planning of these natural systems. The aim of this study was to investigate the impacts of slope aspect on forest dynamic succession in Northwest China by using the dynamic forest succession model (FAREAST). First, the simulated forest composition and vertical forest zonation produced by the model were compared against recorded data in three sub-regions of the Altai Mountains. The FAREAST model accurately reproduced the vertical zonation, forest composition, growth curves of the dominant species (Larix sibirica), and forest biomass in the Altai Mountains. Transitions along the forest zones of the Altai Mountains averaged about a 400 m difference between the northern and southern sites. Biomass for forests on north-facing slopes were 11.0, 15.3 and 55.9 t C ha-1 higher than for south-facing slopes in the Northeast, Central and Southeast sub-regions, respectively. Second, our analyses showed that the FAREAST model can be used to predict dynamic forest succession in Northwest China under the influence of slope and aspect. In the Altai Mountains, the north-facing slopes supported the best forest growth, followed by the west- and east-facing slopes. South-facing slopes consistently exhibited the lowest growth, biomass storage and forest diversity.

  20. A method to isolate bacterial communities and characterize ecosystems from food products: Validation and utilization in as a reproducible chicken meat model.

    Science.gov (United States)

    Rouger, Amélie; Remenant, Benoit; Prévost, Hervé; Zagorec, Monique

    2017-04-17

    Influenced by production and storage processes and by seasonal changes the diversity of meat products microbiota can be very variable. Because microbiotas influence meat quality and safety, characterizing and understanding their dynamics during processing and storage is important for proposing innovative and efficient storage conditions. Challenge tests are usually performed using meat from the same batch, inoculated at high levels with one or few strains. Such experiments do not reflect the true microbial situation, and the global ecosystem is not taken into account. Our purpose was to constitute live stocks of chicken meat microbiotas to create standard and reproducible ecosystems. We searched for the best method to collect contaminating bacterial communities from chicken cuts to store as frozen aliquots. We tested several methods to extract DNA of these stored communities for subsequent PCR amplification. We determined the best moment to collect bacteria in sufficient amounts during the product shelf life. Results showed that the rinsing method associated to the use of Mobio DNA extraction kit was the most reliable method to collect bacteria and obtain DNA for subsequent PCR amplification. Then, 23 different chicken meat microbiotas were collected using this procedure. Microbiota aliquots were stored at -80°C without important loss of viability. Their characterization by cultural methods confirmed the large variability (richness and abundance) of bacterial communities present on chicken cuts. Four of these bacterial communities were used to estimate their ability to regrow on meat matrices. Challenge tests performed on sterile matrices showed that these microbiotas were successfully inoculated and could overgrow the natural microbiota of chicken meat. They can therefore be used for performing reproducible challenge tests mimicking a true meat ecosystem and enabling the possibility to test the influence of various processing or storage conditions on complex meat

  1. Preserve specimens for reproducibility

    Czech Academy of Sciences Publication Activity Database

    Krell, F.-T.; Klimeš, Petr; Rocha, L. A.; Fikáček, M.; Miller, S. E.

    2016-01-01

    Roč. 539, č. 7628 (2016), s. 168 ISSN 0028-0836 Institutional support: RVO:60077344 Keywords : reproducibility * specimen * biodiversity Subject RIV: EH - Ecology, Behaviour Impact factor: 40.137, year: 2016 http://www.nature.com/nature/journal/v539/n7628/full/539168b.html

  2. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised Reporting for Model Reproducibility, Interoperability, and Data Sharing

    Science.gov (United States)

    Quinn, TA; Granite, S; Allessie, MA; Antzelevitch, C; Bollensdorff, C; Bub, G; Burton, RAB; Cerbai, E; Chen, PS; Delmar, M; DiFrancesco, D; Earm, YE; Efimov, IR; Egger, M; Entcheva, E; Fink, M; Fischmeister, R; Franz, MR; Garny, A; Giles, WR; Hannes, T; Harding, SE; Hunter, PJ; Iribe, G; Jalife, J; Johnson, CR; Kass, RS; Kodama, I; Koren, G; Lord, P; Markhasin, VS; Matsuoka, S; McCulloch, AD; Mirams, GR; Morley, GE; Nattel, S; Noble, D; Olesen, SP; Panfilov, AV; Trayanova, NA; Ravens, U; Richard, S; Rosenbaum, DS; Rudy, Y; Sachs, F; Sachse, FB; Saint, DA; Schotten, U; Solovyova, O; Taggart, P; Tung, L; Varró, A; Volders, PG; Wang, K; Weiss, JN; Wettwer, E; White, E; Wilders, R; Winslow, RL; Kohl, P

    2011-01-01

    Cardiac experimental electrophysiology is in need of a well-defined Minimum Information Standard for recording, annotating, and reporting experimental data. As a step toward establishing this, we present a draft standard, called Minimum Information about a Cardiac Electrophysiology Experiment (MICEE). The ultimate goal is to develop a useful tool for cardiac electrophysiologists which facilitates and improves dissemination of the minimum information necessary for reproduction of cardiac electrophysiology research, allowing for easier comparison and utilisation of findings by others. It is hoped that this will enhance the integration of individual results into experimental, computational, and conceptual models. In its present form, this draft is intended for assessment and development by the research community. We invite the reader to join this effort, and, if deemed productive, implement the Minimum Information about a Cardiac Electrophysiology Experiment standard in their own work. PMID:21745496

  3. The business of emergency medicine: a model for success.

    Science.gov (United States)

    Proctor, John; Hall, Peter; Carr, Janet

    2004-02-01

    Today's EPOs and their physicians face an array of daunting challenges. Falling reimbursement, rising malpractice costs. ED and hospital crowding,and demands for improving ED efficiency and patient satisfaction all contribute to the challenging and sometimes threatening environment of EM practice. The EP involved in a busy and often hectic ED shift may feel unduly and unnecessarily distracted when required to continuously acknowledge and address the business aspect of the practice. Nevertheless,regardless of the size and structure, fiscal viability ultimately determines the EPO's ability to continue to offer access to care. This article contends that a comprehensive business strategy drives superior financial performance and supports the organization's mission. The business strategy must identify financial and non-financial determinants of the EPO's success and provide a mechanism for understanding how the organization's resources are converted to value for customers. The section offers a framework for developing this strategy, for identifying possible gaps or deficiencies, and for measuring and monitoring progress in achieving strategic objectives and ultimately, the EPO's mission. The importance of the mission and the dynamic EM environment require that the strategy development process be more than an annual exercise for the leadership of the organization. Though key leaders in any size EPO--set the course for the organization, the entire organization must be aware and understand the strategy before they commit themselves and adopt actions and behaviors that promote it. The model presented here provides a graphic display that lends itself well to consistent communication of a comprehensive strategy in a concise way throughout the organization.Furthermore, the balance of the model, across four perspectives, recognizes the value of balanced organizational objectives and lends itself well to the creation of a measurement system that supports cause and effect

  4. Reproducibility of haemodynamical simulations in a subject-specific stented aneurysm model--a report on the Virtual Intracranial Stenting Challenge 2007.

    Science.gov (United States)

    Radaelli, A G; Augsburger, L; Cebral, J R; Ohta, M; Rüfenacht, D A; Balossino, R; Benndorf, G; Hose, D R; Marzo, A; Metcalfe, R; Mortier, P; Mut, F; Reymond, P; Socci, L; Verhegghe, B; Frangi, A F

    2008-07-19

    This paper presents the results of the Virtual Intracranial Stenting Challenge (VISC) 2007, an international initiative whose aim was to establish the reproducibility of state-of-the-art haemodynamical simulation techniques in subject-specific stented models of intracranial aneurysms (IAs). IAs are pathological dilatations of the cerebral artery walls, which are associated with high mortality and morbidity rates due to subarachnoid haemorrhage following rupture. The deployment of a stent as flow diverter has recently been indicated as a promising treatment option, which has the potential to protect the aneurysm by reducing the action of haemodynamical forces and facilitating aneurysm thrombosis. The direct assessment of changes in aneurysm haemodynamics after stent deployment is hampered by limitations in existing imaging techniques and currently requires resorting to numerical simulations. Numerical simulations also have the potential to assist in the personalized selection of an optimal stent design prior to intervention. However, from the current literature it is difficult to assess the level of technological advancement and the reproducibility of haemodynamical predictions in stented patient-specific models. The VISC 2007 initiative engaged in the development of a multicentre-controlled benchmark to analyse differences induced by diverse grid generation and computational fluid dynamics (CFD) technologies. The challenge also represented an opportunity to provide a survey of available technologies currently adopted by international teams from both academic and industrial institutions for constructing computational models of stented aneurysms. The results demonstrate the ability of current strategies in consistently quantifying the performance of three commercial intracranial stents, and contribute to reinforce the confidence in haemodynamical simulation, thus taking a step forward towards the introduction of simulation tools to support diagnostics and

  5. Accuracy and reproducibility of voxel based superimposition of cone beam computed tomography models on the anterior cranial base and the zygomatic arches.

    Directory of Open Access Journals (Sweden)

    Rania M Nada

    Full Text Available Superimposition of serial Cone Beam Computed Tomography (CBCT scans has become a valuable tool for three dimensional (3D assessment of treatment effects and stability. Voxel based image registration is a newly developed semi-automated technique for superimposition and comparison of two CBCT scans. The accuracy and reproducibility of CBCT superimposition on the anterior cranial base or the zygomatic arches using voxel based image registration was tested in this study. 16 pairs of 3D CBCT models were constructed from pre and post treatment CBCT scans of 16 adult dysgnathic patients. Each pair was registered on the anterior cranial base three times and on the left zygomatic arch twice. Following each superimposition, the mean absolute distances between the 2 models were calculated at 4 regions: anterior cranial base, forehead, left and right zygomatic arches. The mean distances between the models ranged from 0.2 to 0.37 mm (SD 0.08-0.16 for the anterior cranial base registration and from 0.2 to 0.45 mm (SD 0.09-0.27 for the zygomatic arch registration. The mean differences between the two registration zones ranged between 0.12 to 0.19 mm at the 4 regions. Voxel based image registration on both zones could be considered as an accurate and a reproducible method for CBCT superimposition. The left zygomatic arch could be used as a stable structure for the superimposition of smaller field of view CBCT scans where the anterior cranial base is not visible.

  6. Sustaining a successful RN compensation model through transparency and communication.

    Science.gov (United States)

    Reid, Karmen R; Attlesey-Pries, Jacqueline M; Syverson, Renae C; Uthke, Lorraine D; Wottreng, Diane M; Muehlenbein, Michael J

    2011-02-01

    In the March 2005 issue of The Journal of Nursing Administration, authors from an academic medical center outlined a new RN salary program that addressed recruitment and retention of valued resources and established an approach for pay and pay practices for staff RNs across an integrated practice. This follow-up article describes experiences in implementing the program and the successful outcomes achieved.

  7. Two-Year Apprenticeships--A Successful Model of Training?

    Science.gov (United States)

    Kammermann, Marlise; Stalder, Barbara E.; Hattich, Achim

    2011-01-01

    Educational policy is asked to support young people in their successful transition from education to employment. In Switzerland, a two-year apprenticeship with Federal VET Certificate was established in 2002 aimed at increasing the employability of low-achieving school leavers. It is a low-threshold VET programme offering standardised vocational…

  8. Modeling succession of key resource-harvesting traits of mixotrophic plankton

    DEFF Research Database (Denmark)

    Berge, Terje; Chakraborty, Subhendu; Hansen, Per Juel

    2017-01-01

    building blocks for growth, the model reproduces the observed light-dependent ingestion rates and species-specific growth rates with and without prey from the laboratory. The combination of traits yielding the highest growth rate suggests high investments in photosynthesis, and inorganic nutrient uptake...

  9. Modelling the rate of secondary succession after farmland abandonment in a Mediterranean mountain area

    NARCIS (Netherlands)

    Beguería, S.; Pueyo, Y.

    2007-01-01

    Secondary succession after farmland abandonment has become a common process in north Mediterranean countries, especially in mountain areas. In this paper a methodology is tested which combines Markov chains and logistic multivariate regression to model secondary succession after farmland

  10. Reproducibility of ultrasonic testing

    International Nuclear Information System (INIS)

    Lecomte, J.-C.; Thomas, Andre; Launay, J.-P.; Martin, Pierre

    The reproducibility of amplitude quotations for both artificial and natural reflectors was studied for several combinations of instrument/search unit, all being of the same type. This study shows that in industrial inspection if a range of standardized equipment is used, a margin of error of about 6 decibels has to be taken into account (confidence interval of 95%). This margin is about 4 to 5 dB for natural or artificial defects located in the central area and about 6 to 7 dB for artificial defects located on the back surface. This lack of reproducibility seems to be attributable first to the search unit and then to the instrument and operator. These results were confirmed by analysis of calibration data obtained from 250 tests performed by 25 operators under shop conditions. The margin of error was higher than the 6 dB obtained in the study [fr

  11. The Quantum Atomic Model "Electronium": A Successful Teaching Tool.

    Science.gov (United States)

    Budde, Marion; Niedderer, Hans; Scott, Philip; Leach, John

    2002-01-01

    Focuses on the quantum atomic model Electronium. Outlines the Bremen teaching approach in which this model is used, and analyzes the learning of two students as they progress through the teaching unit. (Author/MM)

  12. Retrospective Correction of Physiological Noise: Impact on Sensitivity, Specificity, and Reproducibility of Resting-State Functional Connectivity in a Reading Network Model.

    Science.gov (United States)

    Krishnamurthy, Venkatagiri; Krishnamurthy, Lisa C; Schwam, Dina M; Ealey, Ashley; Shin, Jaemin; Greenberg, Daphne; Morris, Robin D

    2018-03-01

    It is well accepted that physiological noise (PN) obscures the detection of neural fluctuations in resting-state functional connectivity (rsFC) magnetic resonance imaging. However, a clear consensus for an optimal PN correction (PNC) methodology and how it can impact the rsFC signal characteristics is still lacking. In this study, we probe the impact of three PNC methods: RETROICOR: (Glover et al., 2000 ), ANATICOR: (Jo et al., 2010 ), and RVTMBPM: (Bianciardi et al., 2009 ). Using a reading network model, we systematically explore the effects of PNC optimization on sensitivity, specificity, and reproducibility of rsFC signals. In terms of specificity, ANATICOR was found to be effective in removing local white matter (WM) fluctuations and also resulted in aggressive removal of expected cortical-to-subcortical functional connections. The ability of RETROICOR to remove PN was equivalent to removal of simulated random PN such that it artificially inflated the connection strength, thereby decreasing sensitivity. RVTMBPM maintained specificity and sensitivity by balanced removal of vasodilatory PN and local WM nuisance edges. Another aspect of this work was exploring the effects of PNC on identifying reading group differences. Most PNC methods accounted for between-subject PN variability resulting in reduced intersession reproducibility. This effect facilitated the detection of the most consistent group differences. RVTMBPM was most effective in detecting significant group differences due to its inherent sensitivity to removing spatially structured and temporally repeating PN arising from dense vasculature. Finally, results suggest that combining all three PNC resulted in "overcorrection" by removing signal along with noise.

  13. The Carerra Model: A Success in Pregnancy Prevention.

    Science.gov (United States)

    Elling, Duane M.

    This document outlines the development, evaluation, and replication of the Carrera model for pregnancy prevention. The Carerra model helps teens avoid pregnancy by empowering them to develop and reach personal goals, and by providing them with information on sexual issues, including abstinence, contraception, and the consequences of sexual…

  14. Successes and failures of the constituent quark model

    International Nuclear Information System (INIS)

    Lipkin, H.J.

    1982-01-01

    Our approach considers the model as a possible bridge between QCD and the experimental data and examines its predictions to see where these succeed and where they fail. We also attempt to improve the model by looking for additional simple assumptions which give better fits to the experimental data. But we avoid complicated models with too many ad hoc assumptions and too many free parameters; these can fit everything but teach us nothing. We define our constituent quark model by analogy with the constituent electron model of the atom and the constituent nucleon model of the nucleus. In the same way that an atom is assumed to consist only of constituent electrons and a central Coulomb field and a nucleus is assumed to consist only of constituent nucleons hadrons are assumed to consist only of their constituent valence quarks with no bag, no glue, no ocean, nor other constituents. Although these constituent models are oversimplified and neglect other constituents we push them as far as we can. Atomic physics has photons and vacuum polarization as well as constituent electrons, but the constituent model is adequate for calculating most features of the spectrum when finer details like the Lamb shift are neglected. 54 references

  15. A Multi-Stage Maturity Model for Long-Term IT Outsourcing Relationship Success

    Science.gov (United States)

    Luong, Ming; Stevens, Jeff

    2015-01-01

    The Multi-Stage Maturity Model for Long-Term IT Outsourcing Relationship Success, a theoretical stages-of-growth model, explains long-term success in IT outsourcing relationships. Research showed the IT outsourcing relationship life cycle consists of four distinct, sequential stages: contract, transition, support, and partnership. The model was…

  16. Reproducible research in palaeomagnetism

    Science.gov (United States)

    Lurcock, Pontus; Florindo, Fabio

    2015-04-01

    The reproducibility of research findings is attracting increasing attention across all scientific disciplines. In palaeomagnetism as elsewhere, computer-based analysis techniques are becoming more commonplace, complex, and diverse. Analyses can often be difficult to reproduce from scratch, both for the original researchers and for others seeking to build on the work. We present a palaeomagnetic plotting and analysis program designed to make reproducibility easier. Part of the problem is the divide between interactive and scripted (batch) analysis programs. An interactive desktop program with a graphical interface is a powerful tool for exploring data and iteratively refining analyses, but usually cannot operate without human interaction. This makes it impossible to re-run an analysis automatically, or to integrate it into a larger automated scientific workflow - for example, a script to generate figures and tables for a paper. In some cases the parameters of the analysis process itself are not saved explicitly, making it hard to repeat or improve the analysis even with human interaction. Conversely, non-interactive batch tools can be controlled by pre-written scripts and configuration files, allowing an analysis to be 'replayed' automatically from the raw data. However, this advantage comes at the expense of exploratory capability: iteratively improving an analysis entails a time-consuming cycle of editing scripts, running them, and viewing the output. Batch tools also tend to require more computer expertise from their users. PuffinPlot is a palaeomagnetic plotting and analysis program which aims to bridge this gap. First released in 2012, it offers both an interactive, user-friendly desktop interface and a batch scripting interface, both making use of the same core library of palaeomagnetic functions. We present new improvements to the program that help to integrate the interactive and batch approaches, allowing an analysis to be interactively explored and refined

  17. Towards Reproducibility in Computational Hydrology

    Science.gov (United States)

    Hutton, Christopher; Wagener, Thorsten; Freer, Jim; Han, Dawei; Duffy, Chris; Arheimer, Berit

    2017-04-01

    Reproducibility is a foundational principle in scientific research. The ability to independently re-run an experiment helps to verify the legitimacy of individual findings, and evolve (or reject) hypotheses and models of how environmental systems function, and move them from specific circumstances to more general theory. Yet in computational hydrology (and in environmental science more widely) the code and data that produces published results are not regularly made available, and even if they are made available, there remains a multitude of generally unreported choices that an individual scientist may have made that impact the study result. This situation strongly inhibits the ability of our community to reproduce and verify previous findings, as all the information and boundary conditions required to set up a computational experiment simply cannot be reported in an article's text alone. In Hutton et al 2016 [1], we argue that a cultural change is required in the computational hydrological community, in order to advance and make more robust the process of knowledge creation and hypothesis testing. We need to adopt common standards and infrastructures to: (1) make code readable and re-useable; (2) create well-documented workflows that combine re-useable code together with data to enable published scientific findings to be reproduced; (3) make code and workflows available, easy to find, and easy to interpret, using code and code metadata repositories. To create change we argue for improved graduate training in these areas. In this talk we reflect on our progress in achieving reproducible, open science in computational hydrology, which are relevant to the broader computational geoscience community. In particular, we draw on our experience in the Switch-On (EU funded) virtual water science laboratory (http://www.switch-on-vwsl.eu/participate/), which is an open platform for collaboration in hydrological experiments (e.g. [2]). While we use computational hydrology as

  18. A Model for Physician Leadership Development and Succession Planning.

    Science.gov (United States)

    Dubinsky, Isser; Feerasta, Nadia; Lash, Rick

    2015-01-01

    Although the presence of physicians in formal leadership positions has often been limited to roles of department chiefs, MAC chairs, etc., a growing number of organizations are recruiting physicians to other leadership positions (e.g., VP, CEO) where their involvement is being genuinely sought and valued. While physicians have traditionally risen to leadership positions based on clinical excellence or on a rotational basis, truly effective physician leadership that includes competencies such as strategic planning, budgeting, mentoring, network development, etc., is essential to support organizational goals, improve performance and overall efficiency as well as ensuring the quality of care. In this context, the authors have developed a physician leader development and succession planning matrix and supporting toolkit to assist hospitals in identifying and nurturing the next generation of physician leaders.

  19. Successful public-private partnerships: The NYPD shield model.

    Science.gov (United States)

    Amadeo, Vincent; Iannone, Stephen

    2017-12-01

    This article will identify the challenges that post 9/11 law enforcement faces regarding privatepublic partnerships and describe in detail the NYPD Shield programme, created to combat those challenges. Recommendations made by the 911 Commission included the incorporation of the private sector into future homeland security strategies. One such strategy is NYPD Shield. This programme is a nationally recognized award-winning public-private partnership dedicated to providing counterterrorism training and information sharing with government agencies, non-government organizations, private businesses, and the community. Information is shared through several platforms that include a dedicated website, instruction of counterterrorism training curricula, e-mail alerts, intelligence assessments and the hosting of quarterly conferences. This article also details how the NYPD Shield is providing its successful template to other law enforcement agencies enabling them to initiate similar programmes in their respective jurisdictions, and in doing so joining a National Shield Network.

  20. Business Model Innovation in Incumbent Organizations: : Challenges and Success Routes

    OpenAIRE

    Salama, Ahmad; Parvez, Khawar

    2015-01-01

    In this thesis major challenges of creating business models at incumbents within mature industries are identified along with a mitigation plan. Pressure is upon incumbent organizations in order to keep up with the latest rapid technological advancements, the launching of startups that almost cover every field of business and the continuous change in customers’ tastes and needs. That along with various factors either forced organizations to continually reevaluate their current business models ...

  1. Testing a Model of Teaching for Anxiety and Success for English Language Teaching

    Science.gov (United States)

    Önem, Evrim; Ergenç, Iclal

    2013-01-01

    Much research has shown that there is a negative relationship between high levels of anxiety and success for English language teaching. This paper aimed to test a model of teaching for anxiety and success in English language teaching to affect anxiety and success levels at the same time in a control-experiment group with pre- and post-test study…

  2. Successful Aging: A Psychosocial Resources Model for Very Old Adults

    Directory of Open Access Journals (Sweden)

    G. Kevin Randall

    2012-01-01

    Full Text Available Objectives. Using data from the first two phases of the Georgia Centenarian Study, we proposed a latent factor structure for the Duke OARS domains: Economic Resources, Mental Health, Activities of Daily Living, Physical Health, and Social Resources. Methods. Exploratory and confirmatory factor analyses were conducted on two waves of the Georgia Centenarian Study to test a latent variable measurement model of the five resources; nested model testing was employed to assess the final measurement model for equivalency of factor structure over time. Results. The specified measurement model fit the data well at Time 1. However, at Time 2, Social Resources only had one indicator load significantly and substantively. Supplemental analyses demonstrated that a model without Social Resources adequately fit the data. Factorial invariance over time was confirmed for the remaining four latent variables. Discussion. This study’s findings allow researchers and clinicians to reduce the number of OARS questions asked of participants. This has practical implications because increased difficulties with hearing, vision, and fatigue in older adults may require extended time or multiple interviewer sessions to complete the battery of OARS questions.

  3. Opening Reproducible Research

    Science.gov (United States)

    Nüst, Daniel; Konkol, Markus; Pebesma, Edzer; Kray, Christian; Klötgen, Stephanie; Schutzeichel, Marc; Lorenz, Jörg; Przibytzin, Holger; Kussmann, Dirk

    2016-04-01

    Open access is not only a form of publishing such that research papers become available to the large public free of charge, it also refers to a trend in science that the act of doing research becomes more open and transparent. When science transforms to open access we not only mean access to papers, research data being collected, or data being generated, but also access to the data used and the procedures carried out in the research paper. Increasingly, scientific results are generated by numerical manipulation of data that were already collected, and may involve simulation experiments that are completely carried out computationally. Reproducibility of research findings, the ability to repeat experimental procedures and confirm previously found results, is at the heart of the scientific method (Pebesma, Nüst and Bivand, 2012). As opposed to the collection of experimental data in labs or nature, computational experiments lend themselves very well for reproduction. Some of the reasons why scientists do not publish data and computational procedures that allow reproduction will be hard to change, e.g. privacy concerns in the data, fear for embarrassment or of losing a competitive advantage. Others reasons however involve technical aspects, and include the lack of standard procedures to publish such information and the lack of benefits after publishing them. We aim to resolve these two technical aspects. We propose a system that supports the evolution of scientific publications from static papers into dynamic, executable research documents. The DFG-funded experimental project Opening Reproducible Research (ORR) aims for the main aspects of open access, by improving the exchange of, by facilitating productive access to, and by simplifying reuse of research results that are published over the Internet. Central to the project is a new form for creating and providing research results, the executable research compendium (ERC), which not only enables third parties to

  4. Supporting Sophomore Success through a New Learning Community Model

    Science.gov (United States)

    Virtue, Emily E.; Wells, Gayle; Virtue, Andrew D.

    2013-01-01

    The creation of a Sophomore Learning Community (SLC) model can help address concerns about the "sophomore slump" and sophomore attrition. While managing the logistics of a sophomore LC can be difficult, with proper faculty, staff, and administrative support, positive results can be produced. This article outlines the need for Sophomore…

  5. Carsharing Business Models in Germany: Characteristics, Success and Future Prospects

    NARCIS (Netherlands)

    Munzel, K.L.; Boon, W.P.C.; Frenken, K.; Vaskelainen, T.

    2017-01-01

    Carsharing provides an alternative to private car ownership by allowing car use temporarily on an ondemand basis. Operators provide carsharing services using different business models and ownership structures. We distinguish between cooperative, business-to-consumer (B2C) roundtrip and one-way, as

  6. A Model of Social Selection and Successful Altruism

    Science.gov (United States)

    1989-10-07

    D., The evolution of social behavior. Annual Reviews of Ecological Systems, 5:325-383 (1974). 2. Dawkins , R., The selfish gene . Oxford: Oxford...alive and well. it will be important to re- examine this striking historical experience,-not in terms o, oversimplified models of the " selfish gene ," but...Darwinian Analysis The acceptance by many modern geneticists of the axiom that the basic unit of selection Is the " selfish gene " quickly led to the

  7. Observational constraints on successful model of quintessential Inflation

    Energy Technology Data Exchange (ETDEWEB)

    Geng, Chao-Qiang [Chongqing University of Posts and Telecommunications, Chongqing, 400065 (China); Lee, Chung-Chi [DAMTP, Centre for Mathematical Sciences, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA (United Kingdom); Sami, M. [Centre for Theoretical Physics, Jamia Millia Islamia, New Delhi 110025 (India); Saridakis, Emmanuel N. [Physics Division, National Technical University of Athens, 15780 Zografou Campus, Athens (Greece); Starobinsky, Alexei A., E-mail: geng@phys.nthu.edu.tw, E-mail: lee.chungchi16@gmail.com, E-mail: sami@iucaa.ernet.in, E-mail: Emmanuel_Saridakis@baylor.edu, E-mail: alstar@landau.ac.ru [L. D. Landau Institute for Theoretical Physics RAS, Moscow 119334 (Russian Federation)

    2017-06-01

    We study quintessential inflation using a generalized exponential potential V (φ)∝ exp(−λ φ {sup n} / M {sub Pl} {sup n} ), n >1, the model admits slow-roll inflation at early times and leads to close-to-scaling behaviour in the post inflationary era with an exit to dark energy at late times. We present detailed investigations of the inflationary stage in the light of the Planck 2015 results, study post-inflationary dynamics and analytically confirm the existence of an approximately scaling solution. Additionally, assuming that standard massive neutrinos are non-minimally coupled, makes the field φ dominant once again at late times giving rise to present accelerated expansion of the Universe. We derive observational constraints on the field and time-dependent neutrino masses. In particular, for n =6 (8), the parameter λ is constrained to be, log λ > −7.29 (−11.7); the model produces the spectral index of the power spectrum of primordial scalar (matter density) perturbations as n {sub s} = 0.959 ± 0.001 (0.961 ± 0.001) and tiny tensor-to-scalar ratio, r <1.72 × 10{sup −2} (2.32 × 10{sup −2}) respectively. Consequently, the upper bound on possible values of the sum of neutrino masses Σ m {sub ν} ∼< 2.5 eV significantly enhances compared to that in the standard ΛCDM model.

  8. Modeling Forest Succession among Ecological Land Units in Northern Minnesota

    Directory of Open Access Journals (Sweden)

    George Host

    1998-12-01

    Full Text Available Field and modeling studies were used to quantify potential successional pathways among fine-scale ecological classification units within two geomorphic regions of north-central Minnesota. Soil and overstory data were collected on plots stratified across low-relief ground moraines and undulating sand dunes. Each geomorphic feature was sampled across gradients of topography or soil texture. Overstory conditions were sampled using five variable-radius point samples per plot; soil samples were analyzed for carbon and nitrogen content. Climatic, forest composition, and soil data were used to parameterize the sample plots for use with LINKAGES, a forest growth model that simulates changes in composition and soil characteristics over time. Forest composition and soil properties varied within and among geomorphic features. LINKAGES simulations were using "bare ground" and the current overstory as starting conditions. Northern hardwoods or pines dominated the late-successional communities of morainal and dune landforms, respectively. The morainal landforms were dominated by yellow birch and sugar maple; yellow birch reached its maximum abundance in intermediate landscape positions. On the dune sites, pine was most abundant in drier landscape positions, with white spruce increasing in abundance with increasing soil moisture and N content. The differences in measured soil properties and predicted late-successional composition indicate that ecological land units incorporate some of the key variables that govern forest composition and structure. They further show the value of ecological classification and modeling for developing forest management strategies that incorporate the spatial and temporal dynamics of forest ecosystems.

  9. The social networking application success model : An empirical study of Facebook and Twitter

    NARCIS (Netherlands)

    Ou, Carol; Davison, R.M.; Huang, Q.

    2016-01-01

    Social networking applications (SNAs) are among the fastest growing web applications of recent years. In this paper, we propose a causal model to assess the success of SNAs, grounded on DeLone and McLean’s updated information systems (IS) success model. In addition to their original three dimensions

  10. Successful immunization against Acanthamoeba keratitis in a pig model.

    Science.gov (United States)

    Alizadeh, H; He, Y; McCulley, J P; Ma, D; Stewart, G L; Via, M; Haehling, E; Niederkorn, J Y

    1995-03-01

    The feasibility of inducing protective immunity to Acanthamoeba keratitis was tested in a pig model. Experiments were designed to determine if ocular infection with Acanthamoeba trophozoites would elicit protection against reinfection. Additional experiments examined whether injection of parasite antigens either intramuscularly, subconjunctivally, or by both routes would induce immunity. Therefore, four groups of animals were examined: (a) pigs that had resolved a primary corneal infection with Acanthamoeba; (b) pigs immunized intramuscularly; (c) pigs immunized subconjunctivally; and (d) pigs immunized intramuscularly and subconjunctivally. Animals were subsequently challenged with parasite-laden soft contact lenses and observed clinically for the appearance of Acanthamoeba keratitis. Acanthamoeba-specific serum antibody titers and blastogenic responses of peripheral blood lymphocytes were determined weekly. The results indicated that intramuscular injection of Acanthamoeba antigens failed to protect against ocular infection even though hosts developed high titers of IgG antibodies and displayed lymphocyte blastogenic responses to parasite antigens. Ocular infection alone failed to stimulate immunity in any of the animals. By contrast, 50% of the hosts immunized subconjunctivally were protected against corneal disease, and 100% of the animals immunized by a combination of intramuscular and subconjunctival administration of parasite antigens were completely protected against two separate ocular challenges with infectious parasites. Protection did not correlate with either IgG antibody titers or blastogenic potentials of peripheral blood lymphocytes. Interestingly, ocular infection alone failed to stimulate immunity to subsequent ocular challenge with infectious parasites. Thus, administration of parasite antigen via the subconjunctival route can protect against Acanthamoeba keratitis.

  11. A model for estimating the minimum number of offspring to sample in studies of reproductive success.

    Science.gov (United States)

    Anderson, Joseph H; Ward, Eric J; Carlson, Stephanie M

    2011-01-01

    Molecular parentage permits studies of selection and evolution in fecund species with cryptic mating systems, such as fish, amphibians, and insects. However, there exists no method for estimating the number of offspring that must be assigned parentage to achieve robust estimates of reproductive success when only a fraction of offspring can be sampled. We constructed a 2-stage model that first estimated the mean (μ) and variance (v) in reproductive success from published studies on salmonid fishes and then sampled offspring from reproductive success distributions simulated from the μ and v estimates. Results provided strong support for modeling salmonid reproductive success via the negative binomial distribution and suggested that few offspring samples are needed to reject the null hypothesis of uniform offspring production. However, the sampled reproductive success distributions deviated significantly (χ(2) goodness-of-fit test p value reproductive success distribution at rates often >0.05 and as high as 0.24, even when hundreds of offspring were assigned parentage. In general, reproductive success patterns were less accurate when offspring were sampled from cohorts with larger numbers of parents and greater variance in reproductive success. Our model can be reparameterized with data from other species and will aid researchers in planning reproductive success studies by providing explicit sampling targets required to accurately assess reproductive success.

  12. Modeling movie success when "nobody knows anything": Conditional stable distribution analysis of film returns

    OpenAIRE

    W David Walls

    2004-01-01

    In this paper we apply a recently-developed statistical model that explicitly accounts for the extreme uncertainty surrounding film returns. The conditional distribution of box-office returns is analyzed using the stable distribution regression model. The regression coefficients in this model represent what is known about the correlates of film success while at the same time permitting the variance of film success at the box office to be infinite. The empirical analysis shows that the conditi...

  13. A right to reproduce?

    Science.gov (United States)

    Emson, H E

    1992-10-31

    Conscious control of the environment by homo sapiens has brought almost total release from the controls of ecology that limit the population of all other species. After a mere 10,000 years, humans have brought the planet close to collapse, and all the debate in the world seems unlikely to save it. A combination of uncontrolled breeding and rapacity is propelling us down the slippery slope 1st envisioned by Malthus, dragging the rest of the planet along. Only the conscious control, and most likely voluntary, reimposition of controls on breeding will reduce the overgrowth of humans, and we have far to go in that direction. "According to the United Nations Universal Declaration of Human Rights (1948, articles 16[I] and 16 [III]), Men and women of full age without any limitation due to race, nationality or religion have the right to marry and to found a family ... the family is the natural and fundamental group unit of society." The rhetoric of rights without the balancing of responsibilities is wrong in health care, and even more wrong in the context of world population. The mind-set of dominance and exploitation over the rest of creation has meant human reluctance to admit participation in a system where every part is interdependent. We must balance the right to reproduce with it responsible use, valuing interdependence, understanding, and respect with a duty not to unbalance, damage, or destroy. It is long overdue that we discard every statement of right that is unmatched by the equivalent duty and responsibility.

  14. Measuring online learning systems success: applying the updated DeLone and McLean model.

    Science.gov (United States)

    Lin, Hsiu-Fen

    2007-12-01

    Based on a survey of 232 undergraduate students, this study used the updated DeLone and McLean information systems success model to examine the determinants for successful use of online learning systems (OLS). The results provided an expanded understanding of the factors that measure OLS success. The results also showed that system quality, information quality, and service quality had a significant effect on actual OLS use through user satisfaction and behavioral intention to use OLS.

  15. Successful aging as a continuum of functional independence: lessons from physical disability models of aging.

    NARCIS (Netherlands)

    Lowry, K.A.; Vallejo, A.N.; Studenski, S.A.

    2012-01-01

    Successful aging is a multidimensional construct that could be viewed as a continuum of achievement. Based on the disability model proposed by the WHO International Classification of Functioning, Disability and Health, successful aging includes not only the presence or absence of disease, but also

  16. Osteolytica: An automated image analysis software package that rapidly measures cancer-induced osteolytic lesions in in vivo models with greater reproducibility compared to other commonly used methods.

    Science.gov (United States)

    Evans, H R; Karmakharm, T; Lawson, M A; Walker, R E; Harris, W; Fellows, C; Huggins, I D; Richmond, P; Chantry, A D

    2016-02-01

    Methods currently used to analyse osteolytic lesions caused by malignancies such as multiple myeloma and metastatic breast cancer vary from basic 2-D X-ray analysis to 2-D images of micro-CT datasets analysed with non-specialised image software such as ImageJ. However, these methods have significant limitations. They do not capture 3-D data, they are time-consuming and they often suffer from inter-user variability. We therefore sought to develop a rapid and reproducible method to analyse 3-D osteolytic lesions in mice with cancer-induced bone disease. To this end, we have developed Osteolytica, an image analysis software method featuring an easy to use, step-by-step interface to measure lytic bone lesions. Osteolytica utilises novel graphics card acceleration (parallel computing) and 3-D rendering to provide rapid reconstruction and analysis of osteolytic lesions. To evaluate the use of Osteolytica we analysed tibial micro-CT datasets from murine models of cancer-induced bone disease and compared the results to those obtained using a standard ImageJ analysis method. Firstly, to assess inter-user variability we deployed four independent researchers to analyse tibial datasets from the U266-NSG murine model of myeloma. Using ImageJ, inter-user variability between the bones was substantial (±19.6%), in contrast to using Osteolytica, which demonstrated minimal variability (±0.5%). Secondly, tibial datasets from U266-bearing NSG mice or BALB/c mice injected with the metastatic breast cancer cell line 4T1 were compared to tibial datasets from aged and sex-matched non-tumour control mice. Analyses by both Osteolytica and ImageJ showed significant increases in bone lesion area in tumour-bearing mice compared to control mice. These results confirm that Osteolytica performs as well as the current 2-D ImageJ osteolytic lesion analysis method. However, Osteolytica is advantageous in that it analyses over the entirety of the bone volume (as opposed to selected 2-D images), it

  17. National culture and business model change: a framework for successful expansions

    DEFF Research Database (Denmark)

    Dalby, J.; Nielsen, L.S.; Lueg, Rainer

    2014-01-01

    Dalby, J., Nielsen, Lueg, R., L. S., Pedersen, L., Tomoni, A. C. 2014. National culture and business model change: a framework for successful expansions. Journal of Enterprising Culture, 22(4): 379-498.......Dalby, J., Nielsen, Lueg, R., L. S., Pedersen, L., Tomoni, A. C. 2014. National culture and business model change: a framework for successful expansions. Journal of Enterprising Culture, 22(4): 379-498....

  18. The Success of Linear Bootstrapping Models: Decision Domain-, Expertise-, and Criterion-Specific Meta-Analysis

    Science.gov (United States)

    Kaufmann, Esther; Wittmann, Werner W.

    2016-01-01

    The success of bootstrapping or replacing a human judge with a model (e.g., an equation) has been demonstrated in Paul Meehl’s (1954) seminal work and bolstered by the results of several meta-analyses. To date, however, analyses considering different types of meta-analyses as well as the potential dependence of bootstrapping success on the decision domain, the level of expertise of the human judge, and the criterion for what constitutes an accurate decision have been missing from the literature. In this study, we addressed these research gaps by conducting a meta-analysis of lens model studies. We compared the results of a traditional (bare-bones) meta-analysis with findings of a meta-analysis of the success of bootstrap models corrected for various methodological artifacts. In line with previous studies, we found that bootstrapping was more successful than human judgment. Furthermore, bootstrapping was more successful in studies with an objective decision criterion than in studies with subjective or test score criteria. We did not find clear evidence that the success of bootstrapping depended on the decision domain (e.g., education or medicine) or on the judge’s level of expertise (novice or expert). Correction of methodological artifacts increased the estimated success of bootstrapping, suggesting that previous analyses without artifact correction (i.e., traditional meta-analyses) may have underestimated the value of bootstrapping models. PMID:27327085

  19. The Social Networking Application Success Model: An Empirical Study of Facebook and Twitter

    Directory of Open Access Journals (Sweden)

    Carol X. J. Ou

    2016-06-01

    Full Text Available Social networking applications (SNAs are among the fastest growing web applications of recent years. In this paper, we propose a causal model to assess the success of SNAs, grounded on DeLone and McLean’s updated information systems (IS success model. In addition to their original three dimensions of quality, i.e., system quality, information quality and service quality, we propose that a fourth dimension - networking quality - contributes to SNA success. We empirically examined the proposed research model with a survey of 168 Facebook and 149 Twitter users. The data validates the significant role of networking quality in determining the focal SNA’s success. The theoretical and practical implications are discussed.

  20. Model of Islamic Social Entrepreneurship: A Study on Successful Muslim Social Entrepreneur in Malaysia

    Directory of Open Access Journals (Sweden)

    Boulven Mohd Adib

    2018-01-01

    Full Text Available Since research effort in the area is minimal, there is a clear need to examine the practice of Islamic social entrepreneurship among successful Muslim social entrepreneurs in Malaysia. One such practice is to organize charitable activities to benefit the community through the gains made from entrepreneurial activities that are based on social mission and vision. The research problem is lacking of model on Islamic social entrepreneurship. The main objective of this paper is to develop a Model of Islamic Social Entrepreneurship based on successful Muslim social entrepreneur in Malaysia. The research method used in this study is literature review, content analysis, and interview with 14 participants constituting nine successful Muslim social entrepreneurs and five experts with religious academic backgrounds participated in the study. The research finding shows that model of Islamic social entrepreneurship is the major contribution of the study which could serve as guidelines for successful Muslim social entrepreneurs, particularly young entrepreneurs.

  1. Production process reproducibility and product quality consistency of transient gene expression in HEK293 cells with anti-PD1 antibody as the model protein.

    Science.gov (United States)

    Ding, Kai; Han, Lei; Zong, Huifang; Chen, Junsheng; Zhang, Baohong; Zhu, Jianwei

    2017-03-01

    Demonstration of reproducibility and consistency of process and product quality is one of the most crucial issues in using transient gene expression (TGE) technology for biopharmaceutical development. In this study, we challenged the production consistency of TGE by expressing nine batches of recombinant IgG antibody in human embryonic kidney 293 cells to evaluate reproducibility including viable cell density, viability, apoptotic status, and antibody yield in cell culture supernatant. Product quality including isoelectric point, binding affinity, secondary structure, and thermal stability was assessed as well. In addition, major glycan forms of antibody from different batches of production were compared to demonstrate glycosylation consistency. Glycan compositions of the antibody harvested at different time periods were also measured to illustrate N-glycan distribution over the culture time. From the results, it has been demonstrated that different TGE batches are reproducible from lot to lot in overall cell growth, product yield, and product qualities including isoelectric point, binding affinity, secondary structure, and thermal stability. Furthermore, major N-glycan compositions are consistent among different TGE batches and conserved during cell culture time.

  2. Modeling Success: Using Preenrollment Data to Identify Academically At-Risk Students

    Science.gov (United States)

    Gansemer-Topf, Ann M.; Compton, Jonathan; Wohlgemuth, Darin; Forbes, Greg; Ralston, Ekaterina

    2015-01-01

    Improving student success and degree completion is one of the core principles of strategic enrollment management. To address this principle, institutional data were used to develop a statistical model to identify academically at-risk students. The model employs multiple linear regression techniques to predict students at risk of earning below a…

  3. North Dakota's Experience with the Academy Model: A Successful Replication

    Science.gov (United States)

    Hall, Tom; Clapper, Ann

    2016-01-01

    In this article, professors share how the district/university partnership model thriving at Kansas State University was successfully replicated in North Dakota, and was adapted to match their own department goals. While teacher leadership has become a theme among Kansas State academies, their model was created out of principal preparation efforts.…

  4. Potentials and limitations of using large-scale forest inventory data for evaluating forest succession models

    NARCIS (Netherlands)

    Didion, M.P.; Kupferschmid, A.D.; Lexer, M.J.; Rammer, W.; Seidl, R.; Bugmann, H.

    2009-01-01

    Forest gap models have been applied widely to examine forest development under natural conditions and to investigate the effect of climate change on forest succession. Due to the complexity and parameter requirements of such models a rigorous evaluation is required to build confidence in the

  5. Assessing eGovernment Systems Success: A Validation of the DeLone and McLean Model of Information Systems Success

    Science.gov (United States)

    Wang, Yi-Shun; Liao, Yi-Wen

    2008-01-01

    With the proliferation of the Internet and World Wide Web applications, people are increasingly interacting with government to citizen (G2C) eGovernment systems. It is therefore important to measure the success of G2C eGovernment systems from the citizen's perspective. While general information systems (IS) success models have received much…

  6. Structural equation modeling of a potentially successful person in network marketing

    Directory of Open Access Journals (Sweden)

    Rattana Hiranpong

    2016-01-01

    Full Text Available This study developed a structural equation model to explain the attributes of a potentially successful person in network marketing. The researcher collected data on 400 network marketers, from 10 companies, who had been in business seriously for at least 2 years. The results showed that a potentially successful person in network marketing exhibitted four latent variables: 1 unsatisfied valued life-desire discrepancy 2 effectiveness of choice in closing the gap on discrepancies 3 Phalanuphap—power to move people, and 4 assertiveness when significant others have become an obstacle. There is a causal relationship between these latent variables and success in network marketing, and the structural equation modeling of potentially successful persons in network marketing which was developed in this study fits well with the empirical data.

  7. An excitable cortex and memory model successfully predicts new pseudopod dynamics.

    Directory of Open Access Journals (Sweden)

    Robert M Cooper

    Full Text Available Motile eukaryotic cells migrate with directional persistence by alternating left and right turns, even in the absence of external cues. For example, Dictyostelium discoideum cells crawl by extending distinct pseudopods in an alternating right-left pattern. The mechanisms underlying this zig-zag behavior, however, remain unknown. Here we propose a new Excitable Cortex and Memory (EC&M model for understanding the alternating, zig-zag extension of pseudopods. Incorporating elements of previous models, we consider the cell cortex as an excitable system and include global inhibition of new pseudopods while a pseudopod is active. With the novel hypothesis that pseudopod activity makes the local cortex temporarily more excitable--thus creating a memory of previous pseudopod locations--the model reproduces experimentally observed zig-zag behavior. Furthermore, the EC&M model makes four new predictions concerning pseudopod dynamics. To test these predictions we develop an algorithm that detects pseudopods via hierarchical clustering of individual membrane extensions. Data from cell-tracking experiments agrees with all four predictions of the model, revealing that pseudopod placement is a non-Markovian process affected by the dynamics of previous pseudopods. The model is also compatible with known limits of chemotactic sensitivity. In addition to providing a predictive approach to studying eukaryotic cell motion, the EC&M model provides a general framework for future models, and suggests directions for new research regarding the molecular mechanisms underlying directional persistence.

  8. Model of succession in degraded areas based on carabid beetles (Coleoptera, Carabidae)

    Science.gov (United States)

    Schwerk, Axel; Szyszko, Jan

    2011-01-01

    Abstract Degraded areas constitute challenging tasks with respect to sustainable management of natural resources. Maintaining or even establishing certain successional stages seems to be particularly important. This paper presents a model of the succession in five different types of degraded areas in Poland based on changes in the carabid fauna. Mean Individual Biomass of Carabidae (MIB) was used as a numerical measure for the stage of succession. The run of succession differed clearly among the different types of degraded areas. Initial conditions (origin of soil and origin of vegetation) and landscape related aspects seem to be important with respect to these differences. As characteristic phases, a ‘delay phase’, an ‘increase phase’ and a ‘stagnation phase’ were identified. In general, the runs of succession could be described by four different parameters: (1) ‘Initial degradation level’, (2) ‘delay’, (3) ‘increase rate’ and (4) ‘recovery level’. Applying the analytic solution of the logistic equation, characteristic values for the parameters were identified for each of the five area types. The model is of practical use, because it provides a possibility to compare the values of the parameters elaborated in different areas, to give hints for intervention and to provide prognoses about future succession in the areas. Furthermore, it is possible to transfer the model to other indicators of succession. PMID:21738419

  9. Validation of the DeLone and McLean Information Systems Success Model

    OpenAIRE

    Ojo, Adebowale I.

    2017-01-01

    Objectives This study is an adaptation of the widely used DeLone and McLean information system success model in the context of hospital information systems in a developing country. Methods A survey research design was adopted in the study. A structured questionnaire was used to collect data from 442 health information management personnel in five Nigerian teaching hospitals. A structural equation modeling technique was used to validate the model's constructs. Results It was revealed that syst...

  10. A Partial Test and Development of Delone and Mclean's Model of IS Success

    Directory of Open Access Journals (Sweden)

    Peter Seddon

    1996-11-01

    Full Text Available DeLone and McLean's (1992 comprehensive review of different information system success measures concludes with a model of interrelationships between six IS Success constructs. This paper critically examines the meaning of four of these constructs and the evidence of relationships between them. It then provides results from empirical tests of these relationships. Tests are conducted using both conventional ordinary least squares regression path analysis and structural equation modeling - with substantially similar results. The empirical results provide substantial support for the "up stream" two thirds of DeLone and McLean's model. Three factors. System Quality, Information Quality, and Usefulness, are found to explain 75% of the variance in the overall User Satisfaction measure. The empirical results also provide substantial support for the use of usefulness as an IS success measure, and of the hitherto-unreported importance of "Importance of the task" in user perceptions of IS usefulness.

  11. Impact of supplemental instruction leader on the success of supplemental instruction model

    Science.gov (United States)

    Mahabaduge, Hasitha; Haslam, Jeanne

    Supplemental instruction utilizes peer-assisted study sessions to provide review sessions on course material and an opportunity to discuss and work out problems. The impact of supplemental instruction on student performance is well researched and used in a large number of universities around the world due to its proven success. However, the impact of the student leader who plays a significant role in this model is rarely discussed in the literature. We present a case study on the impact of student leader on the success of supplemental instruction model. This case study was done for an Introductory Physics course correlating student performance and the supplemental instruction sessions they attended. Further analysis revealed that the academic performance and work ethics of the student leader has a significant impact on the success of the supplemental instruction model. Important factors to consider when selecting a student leader, the challenges and possible remedies will also be discussed.

  12. Using the Coronal Evolution to Successfully Forward Model CMEs' In Situ Magnetic Profiles

    Science.gov (United States)

    Kay, C.; Gopalswamy, N.

    2017-12-01

    Predicting the effects of a coronal mass ejection (CME) impact requires knowing if impact will occur, which part of the CME impacts, and its magnetic properties. We explore the relation between CME deflections and rotations, which change the position and orientation of a CME, and the resulting magnetic profiles at 1 AU. For 45 STEREO-era, Earth-impacting CMEs, we determine the solar source of each CME, reconstruct its coronal position and orientation, and perform a ForeCAT (Forecasting a CME's Altered Trajectory) simulation of the coronal deflection and rotation. From the reconstructed and modeled CME deflections and rotations, we determine the solar cycle variation and correlations with CME properties. We assume no evolution between the outer corona and 1 AU and use the ForeCAT results to drive the ForeCAT In situ Data Observer (FIDO) in situ magnetic field model, allowing for comparisons with ACE and Wind observations. We do not attempt to reproduce the arrival time. On average FIDO reproduces the in situ magnetic field for each vector component with an error equivalent to 35% of the average total magnetic field strength when the total modeled magnetic field is scaled to match the average observed value. Random walk best fits distinguish between ForeCAT's ability to determine FIDO's input parameters and the limitations of the simple flux rope model. These best fits reduce the average error to 30%. The FIDO results are sensitive to changes of order a degree in the CME latitude, longitude, and tilt, suggesting that accurate space weather predictions require accurate measurements of a CME's position and orientation.

  13. Information Systems Success In Public Administration: Proposal For An Exploratory Model

    Directory of Open Access Journals (Sweden)

    Deyvison de Lima Oliveira

    2015-12-01

    Full Text Available Investments in Information Systems (IS have been significantly increasing and hence the relevance of the studies on the IS success is persistent. Delone and Mclean (2003 developed an IS successful model which is a benchmark for researches in the area, however, in the perspective of the public sector, studies are still rare. In this research it was sought to propose an exploratory model of successful IS in public administration, from the identification of each construct items of the Delone and McLean (2003 original model, through multiple case studies in three Municipalities and a Town Hall of the Southern Cone of Rondônia state, in Brazil. Based on the empirical research, it was found that the IS success factors in municipal public administration are close to those factors indicated in the reviewed literature, however, showing some particularities of the public sector. A model of successful factors and items of IS, from the confrontation between literature and empirical data, is presented in the end of this work.

  14. Joint modeling of success and treatment discontinuation in in vitro fertilization programs: a retrospective cohort study

    Directory of Open Access Journals (Sweden)

    Troude Pénélope

    2012-08-01

    Full Text Available Abstract Background As discontinuation in in vitro fertilization (IVF programs has been associated with a poor prognosis, one hypothesis is that some couple-specific predictive factors in IVF may be shared with opposite effect by both success (i.e. live birth and treatment discontinuation processes. Our objective was to perform a joint analysis of these two processes to examine the hypothesis of a link between the two processes. Methods Analyses were conducted on a retrospective cohort of 3,002 women who began IVF between 1998 and 2002 in two French IVF centers: a Parisian center and a center in a medium-sized city in central France. A shared random effects model based on a joint modelization of IVF treatment success and discontinuation was used to study the link between the two processes. Results Success and discontinuation processes were significantly linked in the medium-sized city center, whereas they were not linked in the Parisian center. The center influenced risk of treatment discontinuation but not chance of success. The well-known inverse-J relation between the woman’s age and chance of success was observed, as expected. Risk of discontinuation globally increased as the woman’s age increased. Conclusions The link between success and discontinuation processes could depend on the fertility center. In particular, the woman’s decision to pursue or to discontinue IVF in a particular center could depend on the presence of other IVF centers in the surrounding area.

  15. Critical success factors model developing for sustainable Kaizen implementation in manufactur-ing industry in Ethiopia

    Directory of Open Access Journals (Sweden)

    Haftu Hailu

    2017-12-01

    Full Text Available The purpose of the research is to identify critical success factors and model developing for sustaining kaizen implementation. Peacock shoe is one of the manufacturing industries in Ethiopia facing challenges on sustaining. The methodology followed is factor analysis and empirically testing hypothesis. A database was designed using SPSS version 20. The survey was validated using statistical validation using the Cronbach alpha index; the result is 0.908. The KMO index value was obtained for the 32 items and had a value of 0.642 with Bartlett's Test of Sphericity Approx. Chi-Square 4503.007, degree of freedom 496 and significance value 0.000. A factor analysis by principal components and varimax rotation was applied for finding the critical success factors. Finding designates that 32 items were merged into eight critical success factors. All the eight factors together explain for 76.941 % of the variance. Multiple regression model analysis has indicated that some of the critical success factors had relationship with success indicators. Due to constraint of time, the researcher focused only at peacock shoe manufacturing industry. Other limitation also includes the absence of any local research that shows the critical success factors at the moment.

  16. Modelling the critical success factors of agile software development projects in South Africa

    Directory of Open Access Journals (Sweden)

    Tawanda B. Chiyangwa

    2017-10-01

    Full Text Available Background: The continued in failure of agile and traditional software development projects have led to the consideration, attention and dispute to critical success factors that are the aspects which are most vital to make a software engineering methodology fruitful. Although there is an increasing variety of critical success factors and methodologies, the conceptual frameworks which have causal relationship are limited. Objective: The objective of this study was to identify and provide insights into the critical success factors that influence the success of software development projects using agile methodologies in South Africa. Method: Quantitative method of collecting data was used. Data were collected in South Africa through a Web-based survey using structured questionnaires. Results: These results show that organisational factors have a great influence on performance expectancy characteristics. Conclusion: The results of this study discovered a comprehensive model that could provide guidelines to the agile community and to the agile professionals.

  17. Information System Success Model for Customer Relationship Management System in Health Promotion Centers

    Science.gov (United States)

    Choi, Wona; Rho, Mi Jung; Park, Jiyun; Kim, Kwang-Jum; Kwon, Young Dae

    2013-01-01

    Objectives Intensified competitiveness in the healthcare industry has increased the number of healthcare centers and propelled the introduction of customer relationship management (CRM) systems to meet diverse customer demands. This study aimed to develop the information system success model of the CRM system by investigating previously proposed indicators within the model. Methods The evaluation areas of the CRM system includes three areas: the system characteristics area (system quality, information quality, and service quality), the user area (perceived usefulness and user satisfaction), and the performance area (personal performance and organizational performance). Detailed evaluation criteria of the three areas were developed, and its validity was verified by a survey administered to CRM system users in 13 nationwide health promotion centers. The survey data were analyzed by the structural equation modeling method, and the results confirmed that the model is feasible. Results Information quality and service quality showed a statistically significant relationship with perceived usefulness and user satisfaction. Consequently, the perceived usefulness and user satisfaction had significant influence on individual performance as well as an indirect influence on organizational performance. Conclusions This study extends the research area on information success from general information systems to CRM systems in health promotion centers applying a previous information success model. This lays a foundation for evaluating health promotion center systems and provides a useful guide for successful implementation of hospital CRM systems. PMID:23882416

  18. Information system success model for customer relationship management system in health promotion centers.

    Science.gov (United States)

    Choi, Wona; Rho, Mi Jung; Park, Jiyun; Kim, Kwang-Jum; Kwon, Young Dae; Choi, In Young

    2013-06-01

    Intensified competitiveness in the healthcare industry has increased the number of healthcare centers and propelled the introduction of customer relationship management (CRM) systems to meet diverse customer demands. This study aimed to develop the information system success model of the CRM system by investigating previously proposed indicators within the model. THE EVALUATION AREAS OF THE CRM SYSTEM INCLUDES THREE AREAS: the system characteristics area (system quality, information quality, and service quality), the user area (perceived usefulness and user satisfaction), and the performance area (personal performance and organizational performance). Detailed evaluation criteria of the three areas were developed, and its validity was verified by a survey administered to CRM system users in 13 nationwide health promotion centers. The survey data were analyzed by the structural equation modeling method, and the results confirmed that the model is feasible. Information quality and service quality showed a statistically significant relationship with perceived usefulness and user satisfaction. Consequently, the perceived usefulness and user satisfaction had significant influence on individual performance as well as an indirect influence on organizational performance. This study extends the research area on information success from general information systems to CRM systems in health promotion centers applying a previous information success model. This lays a foundation for evaluating health promotion center systems and provides a useful guide for successful implementation of hospital CRM systems.

  19. Focus on connections for successful organizational transformation to model based engineering

    Science.gov (United States)

    Babineau, Guy L.

    2015-05-01

    Organizational Transformation to a Model Based Engineering Culture is a significant goal for Northrop Grumman Electronic Systems in order to achieve objectives of increased engineering performance. While organizational change is difficult, a focus on connections is creating success. Connections include model to model, program phase to program phase and organization to organization all through Model Based techniques. This presentation will address the techniques employed by Northrop Grumman to achieve these results as well as address continued focus and efforts. Model to model connections are very effective in automating implicit linkages between models for the purpose of ensuring consistency across a set of models and also for rapidly assessing impact of change. Program phase to phase connections are very important for reducing development time as well as reducing potential errors in moving from one program phase to another. Organization to organization communication is greatly facilitated using model based techniques to eliminate ambiguity and drive consistency and reuse.

  20. An internally validated prognostic model for success in revision stapes surgery for otosclerosis.

    Science.gov (United States)

    Wegner, Inge; Vincent, Robert; Derks, Laura S M; Rauh, Simone P; Heymans, Martijn W; Stegeman, Inge; Grolman, Wilko

    2018-03-09

    To develop a prediction model that can accurately predict the chance of success following revision stapes surgery in patients with recurrent or persistent otosclerosis at 2- to 6-months follow-up and to validate this model internally. A retrospective cohort study of prospectively gathered data in a tertiary referral center. The associations of 11 prognostic factors with treatment success were tested in 705 cases using multivariable logistic regression analysis with backward selection. Success was defined as a mean air-bone gap closure to 10 dB or less. The most relevant predictors were used to derive a clinical prediction rule to determine the probability of success. Internal validation by means of bootstrapping was performed. Model performance indices, including the Hosmer-Lemeshow test, the area under the receiver operating characteristics curve (AUC), and the explained variance were calculated. Success was achieved in 57.7% of cases at 2- to 6-months follow-up. Certain previous surgical techniques, primary causes of failure leading up to revision stapes surgery, and positions of the prosthesis placed during revision surgery were associated with higher success percentages. The clinical prediction rule performed moderately well in the original dataset (Hosmer-Lemeshow P = .78; AUC = 0.73; explained variance = 22%), which slightly decreased following internal validation by means of bootstrapping (AUC = 0.69; explained variance = 13%). Our study established the importance of previous surgical technique, primary cause of failure, and type of the prosthesis placed during the revision surgery in predicting the probability of success following stapes surgery at 2- to 6-months follow-up. 2b. Laryngoscope, 2018. © 2018 The American Laryngological, Rhinological and Otological Society, Inc.

  1. [Succession caused by beaver (Castor fiber L.) life activity: II. A refined Markov model].

    Science.gov (United States)

    Logofet; Evstigneev, O I; Aleinikov, A A; Morozova, A O

    2015-01-01

    The refined Markov model of cyclic zoogenic successions caused by beaver (Castor fiber L.) life activity represents a discrete chain of the following six states: flooded forest, swamped forest, pond, grassy swamp, shrubby swamp, and wet forest, which correspond to certain stages of succession. Those stages are defined, and a conceptual scheme of probable transitions between them for one time step is constructed from the knowledge of beaver behaviour in small river floodplains of "Bryanskii Les" Reserve. We calibrated the corresponding matrix of transition probabilities according to the optimization principle: minimizing differences between the model outcome and reality; the model generates a distribution of relative areas corresponding to the stages of succession, that has to be compared to those gained from case studies in the Reserve during 2002-2006. The time step is chosen to equal 2 years, and the first-step data in the sum of differences are given various weights, w (between 0 and 1). The value of w = 0.2 is selected due to its optimality and for some additional reasons. By the formulae of finite homogeneous Markov chain theory, we obtained the main results of the calibrated model, namely, a steady-state distribution of stage areas, indexes of cyclicity, and the mean durations (M(j)) of succession stages. The results of calibration give an objective quantitative nature to the expert knowledge of the course of succession and get a proper interpretation. The 2010 data, which are not involved in the calibration procedure, enabled assessing the quality of prediction by the homogeneous model in short-term (from the 2006 situation): the error of model area distribution relative to the distribution observed in 2010 falls into the range of 9-17%, the best prognosis being given by the least optimal matrices (rejected values of w). This indicates a formally heterogeneous nature of succession processes in time. Thus, the refined version of the homogeneous Markov chain

  2. Modeling the Impact of Wilderness Orientation Programs on First-Year Academic Success and Life Purpose

    Science.gov (United States)

    Bailey, Andrew W.; Kang, Hyoung-Kil

    2015-01-01

    Wilderness orientation programs (WOPs) are becoming a popular method of encouraging college student retention and success. Previous studies have identified outcomes and correlates of participation in these programs, but a cohesive model of impact is lacking. The purpose of this study was to assess the impact of WOPs on first-year student success…

  3. The Success of a Policy Model: Irrigation Management Transfer in Mexico

    NARCIS (Netherlands)

    Rap, E.R.

    2006-01-01

    The Mexican policy of Irrigation Management Transfer has been widely propagated as a success and has become a model for other countries seeking to improve the performance of their irrigation systems while also cutting public expenditures. This article analyses the process of policy-making that has

  4. Modelling the Success of Learning Management Systems: Application of Latent Class Segmentation Using FIMIX-PLS

    Science.gov (United States)

    Arenas-Gaitán, Jorge; Rondán-Cataluña, Francisco Javier; Ramírez-Correa, Patricio E.

    2018-01-01

    There is not a unique attitude towards the implementation of digital technology in educational sceneries. This paper aims to validate an adaptation of the DeLone and McLean information systems success model in the context of a learning management system. Furthermore, this study means to prove (1) the necessity of segmenting students in order to…

  5. Modeling management information systems’ success: a study in the domain of further education and training

    CSIR Research Space (South Africa)

    Visser, M

    2012-10-01

    Full Text Available system’s evaluation theory and an analysis of FET policy documents were used to propose an initial success evaluation model and tool (questionnaire) for an educational environment (FET colleges) in South Africa. Using a quantitative approach the tool...

  6. The Effect of 7E Model on Conceptual Success of Students in the Unit of Electromagnetism

    Science.gov (United States)

    Turgut, Umit; Colak, Alp; Salar, Riza

    2016-01-01

    The aim of this study was to investigate the impact of the course materials developed in accordance with 7E model in the unit of electromagnetism in high school physics class on students' conceptual success. The present study was conducted with a total of 52 11th grade students in two separate classrooms at a high school. The action research…

  7. Developing a Model and Applications for Probabilities of Student Success: A Case Study of Predictive Analytics

    Science.gov (United States)

    Calvert, Carol Elaine

    2014-01-01

    This case study relates to distance learning students on open access courses. It demonstrates the use of predictive analytics to generate a model of the probabilities of success and retention at different points, or milestones, in a student journey. A core set of explanatory variables has been established and their varying relative importance at…

  8. Model of Islamic Social Entrepreneurship: A Study on Successful Muslim Social Entrepreneur in Malaysia

    OpenAIRE

    Boulven Mohd Adib; Abdullah S.; Bahari Azizan; Ramli A. J.; Hussin N. S.; Jamaluddin Jamsari; Ahmad Z.

    2018-01-01

    Since research effort in the area is minimal, there is a clear need to examine the practice of Islamic social entrepreneurship among successful Muslim social entrepreneurs in Malaysia. One such practice is to organize charitable activities to benefit the community through the gains made from entrepreneurial activities that are based on social mission and vision. The research problem is lacking of model on Islamic social entrepreneurship. The main objective of this paper is to develop a Model ...

  9. Enhancing reproducibility: Failures from Reproducibility Initiatives underline core challenges.

    Science.gov (United States)

    Mullane, Kevin; Williams, Michael

    2017-08-15

    Efforts to address reproducibility concerns in biomedical research include: initiatives to improve journal publication standards and peer review; increased attention to publishing methodological details that enable experiments to be reconstructed; guidelines on standards for study design, implementation, analysis and execution; meta-analyses of multiple studies within a field to synthesize a common conclusion and; the formation of consortia to adopt uniform protocols and internally reproduce data. Another approach to addressing reproducibility are Reproducibility Initiatives (RIs), well-intended, high-profile, systematically peer-vetted initiatives that are intended to replace the traditional process of scientific self-correction. Outcomes from the RIs reported to date have questioned the usefulness of this approach, particularly when the RI outcome differs from other independent self-correction studies that have reproduced the original finding. As a failed RI attempt is a single outcome distinct from the original study, it cannot provide any definitive conclusions necessitating additional studies that the RI approach has neither the ability nor intent of conducting making it a questionable replacement for self-correction. A failed RI attempt also has the potential to damage the reputation of the author of the original finding. Reproduction is frequently confused with replication, an issue that is more than semantic with the former denoting "similarity" and the latter an "exact copy" - an impossible outcome in research because of known and unknown technical, environmental and motivational differences between the original and reproduction studies. To date, the RI framework has negatively impacted efforts to improve reproducibility, confounding attempts to determine whether a research finding is real. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Exploring the relationship between sustainability and project success - conceptual model and expected relationships

    Directory of Open Access Journals (Sweden)

    Gilbert Silvius

    2016-01-01

    Full Text Available Sustainability is one of the most important challenges of our time. Companies are integrating sustainability in their marketing, communication and their actions. Sustainability has more recently also been linked to project management. The logic behind this link is that sustainability needs change and projects are realizing change. Several studies explored how the concept of sustainability impact project management. The research project reported in this paper elaborates on these works by studying how sustainability affects project success. Project managers, logically, strive for project success and considering sustainability may influence this success. Based upon a review of relevant literature, the paper develops a conceptual model that provides a more detailed understanding of how considering different dimensions of sustainability may affect the individual criteria of project success. The study also provides a conceptual mapping of the different relationships between dimensions of sustainability and criteria of project success. This mapping shows that the most positive relationships are expected for the relationship between sustainability and the success criteria stakeholder satisfaction, future readiness and controlled project execution. The expected relationship between considering sustainability and completing the project on schedule and within budget is uncertain.

  11. Modeling future scenarios of light attenuation and potential seagrass success in a eutrophic estuary

    Science.gov (United States)

    del Barrio, Pilar; Ganju, Neil K.; Aretxabaleta, Alfredo L.; Hayn, Melanie; García, Andrés; Howarth, Robert W.

    2014-01-01

    Estuarine eutrophication has led to numerous ecological changes, including loss of seagrass beds. One potential cause of these losses is a reduction in light availability due to increased attenuation by phytoplankton. Future sea level rise will also tend to reduce light penetration and modify seagrass habitat. In the present study, we integrate a spectral irradiance model into a biogeochemical model coupled to the Regional Ocean Model System (ROMS). It is linked to a bio-optical seagrass model to assess potential seagrass habitat in a eutrophic estuary under future nitrate loading and sea-level rise scenarios. The model was applied to West Falmouth Harbor, a shallow estuary located on Cape Cod (Massachusetts) where nitrate from groundwater has led to eutrophication and seagrass loss in landward portions of the estuary. Measurements of chlorophyll, turbidity, light attenuation, and seagrass coverage were used to assess the model accuracy. Mean chlorophyll based on uncalibrated in-situ fluorometry varied from 28 μg L−1 at the landward-most site to 6.5 μg L−1 at the seaward site, while light attenuation ranged from 0.86 to 0.45 m-1. The model reproduced the spatial variability in chlorophyll and light attenuation with RMS errors of 3.72 μg L−1 and 0.07 m-1 respectively. Scenarios of future nitrate reduction and sea-level rise suggest an improvement in light climate in the landward basin with a 75% reduction in nitrate loading. This coupled model may be useful to assess habitat availability changes due to eutrophication and sediment resuspension and fully considers spatial variability on the tidal timescale.

  12. Temple Health Connection: a successful collaborative model of community-based primary health care.

    Science.gov (United States)

    Rothman, Nancy L; Lourie, Rita J; Brian, Donna; Foley, Margaret

    2005-01-01

    Temple Health Connection exemplifies the education, research, and service missions of the university through the provision of culturally competent and effective primary health care. This article reports on the history and successes of a community-based, community-driven academic nursing center at Temple University in Philadelphia, Pennsylvania. Pender's Health Promotion Model has been used to guide the design of interventions, and theoretical propositions are related to community programs and projects. Demographic characteristics of the population served and statistics on both primary care and community outreach efforts are presented. Collaborative efforts are framed in terms of successful funding and programming initiatives.

  13. A Primary Human Critical Success Factors Model for the ERP System Implementation

    Directory of Open Access Journals (Sweden)

    Jenko Aleksander

    2016-08-01

    Full Text Available Background and Purpose: Many researchers have investigated various Critical success factors (CSFs and the different causes of ERP implementation project failures. Despite a detailed literature preview, we were unable to find an appropriate research with a comprehensive overview of the true causes behind CSFs, observed from a human factors perspective. The objective of this research was therefore to develop and evaluate the Primary human factors (PHFs model and to confirm the significant impact of PHFs on traditional CSFs and on the project success.

  14. Education and Successful Aging Trajectories: A Longitudinal Population-Based Latent Variable Modelling Analysis.

    Science.gov (United States)

    Cosco, Theodore D; Stephan, Blossom C M; Brayne, Carol; Muniz, Graciela

    2017-12-01

    As the population ages, interest is increasing in studying aging well. However, more refined means of examining predictors of biopsychosocial conceptualizations of successful aging (SA) are required. Existing evidence of the relationship between early-life education and later-life SA is unclear. The Successful Aging Index (SAI) was mapped onto the Cognitive Function and Aging Study (CFAS), a longitudinal population-based cohort (n = 1,141). SAI scores were examined using growth mixture modelling (GMM) to identify SA trajectories. Unadjusted and adjusted (age, sex, occupational status) ordinal logistic regressions were conducted to examine the association between trajectory membership and education level. GMM identified a three-class model, capturing high, moderate, and low functioning trajectories. Adjusted ordinal logistic regression models indicated that individuals in higher SAI classes were significantly more likely to have higher educational attainment than individuals in the lower SAI classes. These results provide evidence of a life course link between education and SA.

  15. A practice model for rural district nursing success in end-of-life advocacy care.

    Science.gov (United States)

    Reed, Frances M; Fitzgerald, Les; Bish, Melanie R

    2017-08-24

    The development of a practice model for rural district nursing successful end-of-life advocacy care. Resources to help people live well in the end stages of life in rural areas can be limited and difficult to access. District nurse advocacy may promote end-of-life choice for people living at home in rural Australia. The lack of evidence available internationally to inform practice in this context was addressed by exploratory study. A pragmatic mixed method study approved by the University Faculty Ethics Committee and conducted from March 2014 to August 2015 was used to explore the successful end-of-life advocacy of 98 rural Australian district nurses. The findings and results were integrated then compared with theory in this article to develop concepts for a practice model. The model illustrates rural district nurse advocacy success based on respect for the rights and values of people. Advocacy action is motivated by the emotional responses of nurses to the end-of-life vulnerability people experience. The combination of willing investment in relationships, knowing the rural people and resources, and feeling supported, together enables district nurses to develop therapeutic emotional intelligence. This skill promotes moral agency in reflection and advocacy action to overcome emotional and ethical care challenges of access and choice using holistic assessment, communication, organisation of resources and empowering support for the self-determination of person-centred end-of-life goals. Recommendations are proposed from the theoretical concepts in the model. Testing the model in practice is recommended to gain the perceptions of a broader range of rural people both giving and receiving end-of-life-care. A model developed by gathering and comparing district nursing experiences and understanding using mixed methods and existing theory offers evidence for practice of a philosophy of successful person-centred advocacy care in a field of nursing that lacks specific

  16. Successful completion of the Qinshan phase III nuclear power plant-a successful model for Chinese-Canadian cooperation

    International Nuclear Information System (INIS)

    Peng Xiaoxing

    2004-01-01

    This report documents Qinshan CANDU project construction and commissioning experience as well as management strategies and approaches that contributed to the successful completion of the project. The Qinshan phase III (CANDU) nuclear power plant was built in record times: Unit 1 achieved commercial operation on December 31, 2002 and Unit 2 on July 24, 2003, 43 days and 112 days ahead of schedule respectively. The reference plant design is the Wolsong 3 and 4 CANDU-6 units in the Republic of Korea. Improvements in design and construction methods allowed Unit 1 to be constructed in 51.5 Months from First Concrete to Criticality-a record in China for nuclear power plants. The key factors are project management and project management tools, quality assurance, construction methods (including open top construction, heavy lifts and modularization), electronic documentation with configuration control that provides up-to-date on-line information, CADDS design linked with material management, specialized material control including bar coding, and planning. The introduction of new design and construction techniques was achieved by combining conventional AECL practices with working experiences in China. The most advanced tools and techniques for achieving optimum construction quality, schedule and cost were used. Successful application of advanced project management methods and tools will benefit TQNPC in operation of the station, and the Chinese contractors in advancing their capabilities in future nuclear projects in China and enhancing their opportunities internationally. TQNPC's participation in Quality surveillance (QS) activities of nuclear steam plant (NSP) and Balance of Plant (BOP) offshore equipment benefited TQNPC in acquiring knowledge of specific equipment manufacturing processes, which can be applied to similar activities in China. China has established the capability of manufacturing CANDU fuel and becoming self-reliant in fuel supply. Excellent co-operation and

  17. Testing Reproducibility in Earth Sciences

    Science.gov (United States)

    Church, M. A.; Dudill, A. R.; Frey, P.; Venditti, J. G.

    2017-12-01

    Reproducibility represents how closely the results of independent tests agree when undertaken using the same materials but different conditions of measurement, such as operator, equipment or laboratory. The concept of reproducibility is fundamental to the scientific method as it prevents the persistence of incorrect or biased results. Yet currently the production of scientific knowledge emphasizes rapid publication of previously unreported findings, a culture that has emerged from pressures related to hiring, publication criteria and funding requirements. Awareness and critique of the disconnect between how scientific research should be undertaken, and how it actually is conducted, has been prominent in biomedicine for over a decade, with the fields of economics and psychology more recently joining the conversation. The purpose of this presentation is to stimulate the conversation in earth sciences where, despite implicit evidence in widely accepted classifications, formal testing of reproducibility is rare.As a formal test of reproducibility, two sets of experiments were undertaken with the same experimental procedure, at the same scale, but in different laboratories. Using narrow, steep flumes and spherical glass beads, grain size sorting was examined by introducing fine sediment of varying size and quantity into a mobile coarse bed. The general setup was identical, including flume width and slope; however, there were some variations in the materials, construction and lab environment. Comparison of the results includes examination of the infiltration profiles, sediment mobility and transport characteristics. The physical phenomena were qualitatively reproduced but not quantitatively replicated. Reproduction of results encourages more robust research and reporting, and facilitates exploration of possible variations in data in various specific contexts. Following the lead of other fields, testing of reproducibility can be incentivized through changes to journal

  18. Model for assessing the success of SMEs in the internacionali­zation process

    Directory of Open Access Journals (Sweden)

    Lea Kubíčková

    2010-01-01

    Full Text Available The paper deals with evaluating the success of small and medium-sized companies in in­ter­na­tio­na­li­za­tion process. The process of internationalization is defined in the literature in a many ways; there is a countless variety of different approaches and models of internationalization process of firms. Like all processes in the firm also the internationalization process is accompanied by risks. For risk management it is important to know what the key factors of success are in the international arena. In this article is presented a simple evaluation model that could be used by SMEs to determine not only how strong are they compared to competitors, but also at what level are their key success factors in the process of internationalization. The aim was to find a simple method to help small and medium enterprises to assess their situation in the field of internationalization and to help them identify their strengths and weaknesses in this area. Proposed simple evaluation model has the graphic output from which it can be seen in which areas the company is doing well in internationalization process and in what areas is doing badly – then there is room for further improvement. Creating the model it was essential to divide the various factors into several groups and further evaluation to determine the range by which SMEs can quantify the level of success in internationalization process. Before the model was constructed it was necessary to collect data among small and mid-sized firms, and to process the outputs of the survey. After confirmation or to rejection of the certain hypotheses key success factors of SMEs in the internationalization process were selected and these factors were then aggregated into 4 groups. The model was then applied to data obtained from a survey of 40 SMEs and in the paper there are presented specific examples of graphical output of the model for the best and worst rated company. Authors are aware that the model is

  19. Validation of the DeLone and McLean Information Systems Success Model.

    Science.gov (United States)

    Ojo, Adebowale I

    2017-01-01

    This study is an adaptation of the widely used DeLone and McLean information system success model in the context of hospital information systems in a developing country. A survey research design was adopted in the study. A structured questionnaire was used to collect data from 442 health information management personnel in five Nigerian teaching hospitals. A structural equation modeling technique was used to validate the model's constructs. It was revealed that system quality significantly influenced use (β = 0.53, p Information quality significantly influenced use (β = 0.24, p 0.05), but it significantly influenced perceived net benefits (β = 0.21, p 0.05). The study validates the DeLone and McLean information system success model in the context of a hospital information system in a developing country. Importantly, system quality and use were found to be important measures of hospital information system success. It is, therefore, imperative that hospital information systems are designed in such ways that are easy to use, flexible, and functional to serve their purpose.

  20. European cold winter 2009-2010: How unusual in the instrumental record and how reproducible in the ARPEGE-Climat model?

    Science.gov (United States)

    Ouzeau, G.; Cattiaux, J.; Douville, H.; Ribes, A.; Saint-Martin, D.

    2011-06-01

    Boreal winter 2009-2010 made headlines for cold anomalies in many countries of the northern mid-latitudes. Northern Europe was severely hit by this harsh winter in line with a record persistence of the negative phase of the North Atlantic Oscillation (NAO). In the present study, we first provide a wider perspective on how unusual this winter was by using the recent 20th Century Reanalysis. A weather regime analysis shows that the frequency of the negative NAO was unprecedented since winter 1939-1940, which is then used as a dynamical analog of winter 2009-2010 to demonstrate that the latter might have been much colder without the background global warming observed during the twentieth century. We then use an original nudging technique in ensembles of global atmospheric simulations driven by observed sea surface temperature (SST) and radiative forcings to highlight the relevance of the stratosphere for understanding if not predicting such anomalous winter seasons. Our results demonstrate that an improved representation of the lower stratosphere is necessary to reproduce not only the seasonal mean negative NAO signal, but also its intraseasonal distribution and the corresponding increased probability of cold waves over northern Europe.

  1. A structural equation model to integrate changes in functional strategies during old-field succession.

    Science.gov (United States)

    Vile, Denis; Shipley, Bill; Garnier, Eric

    2006-02-01

    From a functional perspective, changes in abundance, and ultimately species replacement, during succession are a consequence of integrated suites of traits conferring different relative ecological advantages as the environment changes over time. Here we use structural equations to model the interspecific relationships between these integrated functional traits using 34 herbaceous species from a Mediterranean old-field succession and thus quantify the notion of a plant strategy. We measured plant traits related to plant vegetative and reproductive size, leaf functioning, reproductive phenology, seed mass, and production on 15 individuals per species monitored during one growing season. The resulting structural equation model successfully accounts for the pattern of trait covariation during the first 45 years post-abandonment using just two forcing variables: time since site abandonment and seed mass; no association between time since field abandonment and seed mass was observed over these herbaceous stages of secondary succession. All other predicted traits values are determined by these two variables and the cause-effect linkage between them. Adding pre-reproductive vegetative mass as a third forcing variable noticeably increased the predictive power of the model. Increasing the time after abandonment favors species with increasing life span and pre-reproductive biomass and decreasing specific leaf area. Allometric coefficients relating vegetative and reproductive components of plant size were in accordance with allometry theory. The model confirmed the trade-off between seed mass and seed number. Maximum plant height and seed mass were major determinants of reproductive phenology. Our results show that beyond verbal conceptualization, plant ecological strategies can be quantified and modeled.

  2. Reproducibility of a reaming test

    DEFF Research Database (Denmark)

    Pilny, Lukas; Müller, Pavel; De Chiffre, Leonardo

    2012-01-01

    The reproducibility of a reaming test was analysed to document its applicability as a performance test for cutting fluids. Reaming tests were carried out on a drilling machine using HSS reamers. Workpiece material was an austenitic stainless steel, machined using 4.75 m∙min-1 cutting speed and 0....

  3. Reproducibility of a reaming test

    DEFF Research Database (Denmark)

    Pilny, Lukas; Müller, Pavel; De Chiffre, Leonardo

    2014-01-01

    The reproducibility of a reaming test was analysed to document its applicability as a performance test for cutting fluids. Reaming tests were carried out on a drilling machine using HSS reamers. Workpiece material was an austenitic stainless steel, machined using 4.75 m•min−1 cutting speed and 0....

  4. Reproducible Bioinformatics Research for Biologists

    Science.gov (United States)

    This book chapter describes the current Big Data problem in Bioinformatics and the resulting issues with performing reproducible computational research. The core of the chapter provides guidelines and summaries of current tools/techniques that a noncomputational researcher would need to learn to pe...

  5. Bad Behavior: Improving Reproducibility in Behavior Testing.

    Science.gov (United States)

    Andrews, Anne M; Cheng, Xinyi; Altieri, Stefanie C; Yang, Hongyan

    2018-01-24

    Systems neuroscience research is increasingly possible through the use of integrated molecular and circuit-level analyses. These studies depend on the use of animal models and, in many cases, molecular and circuit-level analyses. Associated with genetic, pharmacologic, epigenetic, and other types of environmental manipulations. We illustrate typical pitfalls resulting from poor validation of behavior tests. We describe experimental designs and enumerate controls needed to improve reproducibility in investigating and reporting of behavioral phenotypes.

  6. Use the predictive models to explore the key factors affecting phytoplankton succession in Lake Erhai, China.

    Science.gov (United States)

    Zhu, Rong; Wang, Huan; Chen, Jun; Shen, Hong; Deng, Xuwei

    2018-01-01

    Increasing algae in Lake Erhai has resulted in frequent blooms that have not only led to water ecosystem degeneration but also seriously influenced the quality of the water supply and caused extensive damage to the local people, as the lake is a water resource for Dali City. Exploring the key factors affecting phytoplankton succession and developing predictive models with easily detectable parameters for phytoplankton have been proven to be practical ways to improve water quality. To this end, a systematic survey focused on phytoplankton succession was conducted over 2 years in Lake Erhai. The data from the first study year were used to develop predictive models, and the data from the second year were used for model verification. The seasonal succession of phytoplankton in Lake Erhai was obvious. The dominant groups were Cyanobacteria in the summer, Chlorophyta in the autumn and Bacillariophyta in the winter. The developments and verification of predictive models indicated that compared to phytoplankton biomass, phytoplankton density is more effective for estimating phytoplankton variation in Lake Erhai. CCA (canonical correlation analysis) indicated that TN (total nitrogen), TP (total phosphorus), DO (dissolved oxygen), SD (Secchi depth), Cond (conductivity), T (water temperature), and ORP (oxidation reduction potential) had significant influences (p < 0.05) on the phytoplankton community. The CCA of the dominant species found that Microcystis was significantly influenced by T. The dominant Chlorophyta, Psephonema aenigmaticum and Mougeotia, were significantly influenced by TN. All results indicated that TN and T were the two key factors driving phytoplankton succession in Lake Erhai.

  7. Social Dancing for Successful Ageing: Models for Health, Happiness and Social Inclusion amongst Senior Citizens

    Directory of Open Access Journals (Sweden)

    Jonathan Skinner

    2013-03-01

    Full Text Available Abstract: This article presents findings from a qualitative study of social dancing for successful ageing amongst senior citizens in three locales: in Blackpool (GB, around Belfast (NI, and in Sacramento (US. Findings also attest to the social, psychological and health benefits of social dancing amongst senior citizens. They also articulate three different social dancing models: social dance as tea dance (Sacramento, social dance as practice dance (Blackpool, social dance as motility (Belfast and environs.

  8. Evaluation of Land Surface Models in Reproducing Satellite-Derived LAI over the High-Latitude Northern Hemisphere. Part I: Uncoupled DGVMs

    Directory of Open Access Journals (Sweden)

    Ning Zeng

    2013-10-01

    Full Text Available Leaf Area Index (LAI represents the total surface area of leaves above a unit area of ground and is a key variable in any vegetation model, as well as in climate models. New high resolution LAI satellite data is now available covering a period of several decades. This provides a unique opportunity to validate LAI estimates from multiple vegetation models. The objective of this paper is to compare new, satellite-derived LAI measurements with modeled output for the Northern Hemisphere. We compare monthly LAI output from eight land surface models from the TRENDY compendium with satellite data from an Artificial Neural Network (ANN from the latest version (third generation of GIMMS AVHRR NDVI data over the period 1986–2005. Our results show that all the models overestimate the mean LAI, particularly over the boreal forest. We also find that seven out of the eight models overestimate the length of the active vegetation-growing season, mostly due to a late dormancy as a result of a late summer phenology. Finally, we find that the models report a much larger positive trend in LAI over this period than the satellite observations suggest, which translates into a higher trend in the growing season length. These results highlight the need to incorporate a larger number of more accurate plant functional types in all models and, in particular, to improve the phenology of deciduous trees.

  9. Evaluation of multichannel reproduced sound

    DEFF Research Database (Denmark)

    Choisel, Sylvain; Wickelmaier, Florian Maria

    2007-01-01

    from the quantified attributes predict overall preference well. The findings allow for some generalizations within musical program genres regarding the perception of and preference for certain spatial reproduction modes, but for limited generalizations across selections from different musical genres.......A study was conducted with the goal of quantifying auditory attributes which underlie listener preference for multichannel reproduced sound. Short musical excerpts were presented in mono, stereo and several multichannel formats to a panel of forty selected listeners. Scaling of auditory attributes...

  10. Application of two forest succession models at sites in Northeast Germany

    International Nuclear Information System (INIS)

    Lasch, P.; Lindner, M.

    1995-06-01

    In order to simulate potential impacts of climate change on forests, two succession models were applied to sites in the Northeast German lowlands. The models, which had been developed for Alpine (FORECE) and Boreal (FORSKA) forests differ from each other in the way they represent tree growth processes and the impact of environmental factors on establishment and growth. Both models were adjusted and compared with each other at sites that are situated along an ecological gradient from maritime to subcontinental climate. These sites are extending the former environmental space of model application towards water limited conditions, which under a predicted climatic change may have increasing importance for European forests. First results showed that FORECE was unrealistically sensitive to changes in soil moisture. On the other hand, FORSKA generally simulated very low biomasses. Since the structure of FORSKA seemed to be better suited for the simulation of changing environmental conditions, this model was chosen for further model development, applications and sensitivity analyses. Among other changes, establishment rates were increased and some environmental response factors were analysed. The function of account for resource depletion was modified. After the modifications for Central European conditions were made, there was a decrease in performance for the Boreal site. Both simulated total biomasses and species composition had changed. We conclude, that with currently available models, realistic forest dynamics within different climatic zones of Europe cannot be simulated without more substantial model modifications. (orig.)

  11. Experimental challenges to reproduce seismic fault motion

    Science.gov (United States)

    Shimamoto, T.

    2011-12-01

    This presentation briefly reviews scientific and technical development in the studies of intermediate to high-velocity frictional properties of faults and summarizes remaining technical challenges to reproduce nucleation to growth processes of large earthquakes in laboratory. Nearly 10 high-velocity or low to high-velocity friction apparatuses have been built in the last several years in the world and it has become possible now to produce sub-plate velocity to seismic slip rate in a single machine. Despite spreading of high-velocity friction studies, reproducing seismic fault motion at high P and T conditions to cover the entire seismogenic zone is still a big challenge. Previous studies focused on (1) frictional melting, (2) thermal pressurization, and (3) high-velocity gouge behavior without frictional melting. Frictional melting process was solved as a Stefan problem with very good agreement with experimental results. Thermal pressurization has been solved theoretically based on measured transport properties and has been included successfully in the modeling of earthquake generation. High-velocity gouge experiments in the last several years have revealed that a wide variety of gouges exhibit dramatic weakening at high velocities (e.g., Di Toro et al., 2011, Nature). Most gouge experiments were done under dry conditions partly to separate gouge friction from the involvement of thermal pressurization. However, recent studies demonstrated that dehydration or degassing due to mineral decomposition can occur during seismic fault motion. Those results not only provided a new view of looking at natural fault zones in search of geological evidence of seismic fault motion, but also indicated that thermal pressurization and gouge weakening can occur simultaneously even in initially dry gouge. Thus experiments with controlled pore pressure are needed. I have struggled to make a pressure vessel for wet high-velocity experiments in the last several years. A technical

  12. How well do environmental archives of atmospheric mercury deposition in the Arctic reproduce rates and trends depicted by atmospheric models and measurements?

    Science.gov (United States)

    Goodsite, M E; Outridge, P M; Christensen, J H; Dastoor, A; Muir, D; Travnikov, O; Wilson, S

    2013-05-01

    This review compares the reconstruction of atmospheric Hg deposition rates and historical trends over recent decades in the Arctic, inferred from Hg profiles in natural archives such as lake and marine sediments, peat bogs and glacial firn (permanent snowpack), against those predicted by three state-of-the-art atmospheric models based on global Hg emission inventories from 1990 onwards. Model veracity was first tested against atmospheric Hg measurements. Most of the natural archive and atmospheric data came from the Canadian-Greenland sectors of the Arctic, whereas spatial coverage was poor in other regions. In general, for the Canadian-Greenland Arctic, models provided good agreement with atmospheric gaseous elemental Hg (GEM) concentrations and trends measured instrumentally. However, there are few instrumented deposition data with which to test the model estimates of Hg deposition, and these data suggest models over-estimated deposition fluxes under Arctic conditions. Reconstructed GEM data from glacial firn on Greenland Summit showed the best agreement with the known decline in global Hg emissions after about 1980, and were corroborated by archived aerosol filter data from Resolute, Nunavut. The relatively stable or slowly declining firn and model GEM trends after 1990 were also corroborated by real-time instrument measurements at Alert, Nunavut, after 1995. However, Hg fluxes and trends in northern Canadian lake sediments and a southern Greenland peat bog did not exhibit good agreement with model predictions of atmospheric deposition since 1990, the Greenland firn GEM record, direct GEM measurements, or trends in global emissions since 1980. Various explanations are proposed to account for these discrepancies between atmosphere and archives, including problems with the accuracy of archive chronologies, climate-driven changes in Hg transfer rates from air to catchments, waters and subsequently into sediments, and post-depositional diagenesis in peat bogs

  13. Identifying Successful Advancement Approaches in Four Catholic Universities: The Effectiveness of the Four Advancement Models of Communication

    Science.gov (United States)

    Bonglia, Jean-Pierre K.

    2010-01-01

    The current longitudinal study of the most successful Catholic universities in the United States identifies the prevalence of four advancement models of communication that have contributed to make those institutions successful in their philanthropic efforts. While research by Grunig and Kelly maintained that the two-way symmetrical model of…

  14. Chow-Liu trees are sufficient predictive models for reproducing key features of functional networks of periictal EEG time-series.

    Science.gov (United States)

    Steimer, Andreas; Zubler, Frédéric; Schindler, Kaspar

    2015-09-01

    Seizure freedom in patients suffering from pharmacoresistant epilepsies is still not achieved in 20-30% of all cases. Hence, current therapies need to be improved, based on a more complete understanding of ictogenesis. In this respect, the analysis of functional networks derived from intracranial electroencephalographic (iEEG) data has recently become a standard tool. Functional networks however are purely descriptive models and thus are conceptually unable to predict fundamental features of iEEG time-series, e.g., in the context of therapeutical brain stimulation. In this paper we present some first steps towards overcoming the limitations of functional network analysis, by showing that its results are implied by a simple predictive model of time-sliced iEEG time-series. More specifically, we learn distinct graphical models (so called Chow-Liu (CL) trees) as models for the spatial dependencies between iEEG signals. Bayesian inference is then applied to the CL trees, allowing for an analytic derivation/prediction of functional networks, based on thresholding of the absolute value Pearson correlation coefficient (CC) matrix. Using various measures, the thus obtained networks are then compared to those which were derived in the classical way from the empirical CC-matrix. In the high threshold limit we find (a) an excellent agreement between the two networks and (b) key features of periictal networks as they have previously been reported in the literature. Apart from functional networks, both matrices are also compared element-wise, showing that the CL approach leads to a sparse representation, by setting small correlations to values close to zero while preserving the larger ones. Overall, this paper shows the validity of CL-trees as simple, spatially predictive models for periictal iEEG data. Moreover, we suggest straightforward generalizations of the CL-approach for modeling also the temporal features of iEEG signals. Copyright © 2015 Elsevier Inc. All rights

  15. Theoretical Modeling and Computer Simulations for the Origins and Evolution of Reproducing Molecular Systems and Complex Systems with Many Interactive Parts

    Science.gov (United States)

    Liang, Shoudan

    2000-01-01

    Our research effort has produced nine publications in peer-reviewed journals listed at the end of this report. The work reported here are in the following areas: (1) genetic network modeling; (2) autocatalytic model of pre-biotic evolution; (3) theoretical and computational studies of strongly correlated electron systems; (4) reducing thermal oscillations in atomic force microscope; (5) transcription termination mechanism in prokaryotic cells; and (6) the low glutamine usage in thennophiles obtained by studying completely sequenced genomes. We discuss the main accomplishments of these publications.

  16. Adjustments in the Almod 3W2 code models for reproducing the net load trip test in Angra I nuclear power plant

    International Nuclear Information System (INIS)

    Camargo, C.T.M.; Madeira, A.A.; Pontedeiro, A.C.; Dominguez, L.

    1986-09-01

    The recorded traces got from the net load trip test in Angra I NPP yelded the oportunity to make fine adjustments in the ALMOD 3W2 code models. The changes are described and the results are compared against plant real data. (Author) [pt

  17. An International Ki67 Reproducibility Study

    Science.gov (United States)

    2013-01-01

    Background In breast cancer, immunohistochemical assessment of proliferation using the marker Ki67 has potential use in both research and clinical management. However, lack of consistency across laboratories has limited Ki67’s value. A working group was assembled to devise a strategy to harmonize Ki67 analysis and increase scoring concordance. Toward that goal, we conducted a Ki67 reproducibility study. Methods Eight laboratories received 100 breast cancer cases arranged into 1-mm core tissue microarrays—one set stained by the participating laboratory and one set stained by the central laboratory, both using antibody MIB-1. Each laboratory scored Ki67 as percentage of positively stained invasive tumor cells using its own method. Six laboratories repeated scoring of 50 locally stained cases on 3 different days. Sources of variation were analyzed using random effects models with log2-transformed measurements. Reproducibility was quantified by intraclass correlation coefficient (ICC), and the approximate two-sided 95% confidence intervals (CIs) for the true intraclass correlation coefficients in these experiments were provided. Results Intralaboratory reproducibility was high (ICC = 0.94; 95% CI = 0.93 to 0.97). Interlaboratory reproducibility was only moderate (central staining: ICC = 0.71, 95% CI = 0.47 to 0.78; local staining: ICC = 0.59, 95% CI = 0.37 to 0.68). Geometric mean of Ki67 values for each laboratory across the 100 cases ranged 7.1% to 23.9% with central staining and 6.1% to 30.1% with local staining. Factors contributing to interlaboratory discordance included tumor region selection, counting method, and subjective assessment of staining positivity. Formal counting methods gave more consistent results than visual estimation. Conclusions Substantial variability in Ki67 scoring was observed among some of the world’s most experienced laboratories. Ki67 values and cutoffs for clinical decision-making cannot be transferred between laboratories without

  18. Performance evaluation of public hospital information systems by the information system success model.

    Science.gov (United States)

    Cho, Kyoung Won; Bae, Sung-Kwon; Ryu, Ji-Hye; Kim, Kyeong Na; An, Chang-Ho; Chae, Young Moon

    2015-01-01

    This study was to evaluate the performance of the newly developed information system (IS) implemented on July 1, 2014 at three public hospitals in Korea. User satisfaction scores of twelve key performance indicators of six IS success factors based on the DeLone and McLean IS Success Model were utilized to evaluate IS performance before and after the newly developed system was introduced. All scores increased after system introduction except for the completeness of medical records and impact on the clinical environment. The relationships among six IS factors were also analyzed to identify the important factors influencing three IS success factors (Intention to Use, User Satisfaction, and Net Benefits). All relationships were significant except for the relationships among Service Quality, Intention to Use, and Net Benefits. The results suggest that hospitals should not only focus on systems and information quality; rather, they should also continuously improve service quality to improve user satisfaction and eventually reach full the potential of IS performance.

  19. Modelling the interactions among factors that influence successful computerisation of small business

    Directory of Open Access Journals (Sweden)

    Gerard Fogarty

    2008-05-01

    Full Text Available Small businesses face many problems if they are to survive the first five years of operation. The increasing complexity of information needed to run a business in the 21st Century has added another obstacle to what is already a tough course. Sooner or later, survivors are faced with the prospect of investing in computer based information systems (CBIS. Properly handled, the investment will improve the competitiveness of the company. Badly handled, the investment will handicap the company and perhaps even lead to its closure. Using survey methodology, the present study collected information from 171 small businesses that had purchased computer systems with a view to finding out what factors contribute to successful implementation of CBIS. The variables studied included background characteristics of the organization, background characteristics of the Chief Executive Officer, decision making processes, and a range of variables relating to the performance of the system itself. The outcome variable was user satisfaction. We developed and tested a CBIS implementation success model based on these variables. Results showed that although the performance of the system was the immediate determinant of satisfaction, the background variables had both direct and indirect (mediated effects on satisfaction. These findings emphasise the importance of going beyond the immediate surrounds of a computing environment if one wishes to explain the factors that influence CBIS success in small businesses.

  20. A domestic model for successful implementation of enterprise resource planning (ERP systems in Iranian manufacturing enterprises

    Directory of Open Access Journals (Sweden)

    Mohammad Rahmani

    2012-01-01

    Full Text Available This research investigates the human-behavioral dimension of technology acceptance in enterprises. It is evident that accepting a technology depends on the underlying circumstances of the environment. We have approached this issue from two different angles of social and technological architecture. The research tries to explore proper enterprise architecture for ERP system acceptance. Social Architecture (SA is defined as the set of circumstances that makes people behave in a particular way. So behavior of persons (employees of an enterprise can be a function of SA. Hence acceptance of a system can be dictated by SA and manipulating SA can result in desirable success for a technology system. We have achieved various variables of social architecture and have examined their relevance to system acceptance and success in related enterprises (research domain beside technological architecture variables. The results have indicated that a special form of social and technological architecture can lead to success for ERP system in the enterprises of the research domain. This gave us a model of architecture.

  1. Systematic Methodology for Reproducible Optimizing Batch Operation

    DEFF Research Database (Denmark)

    Bonné, Dennis; Jørgensen, Sten Bay

    2006-01-01

    contribution furthermore presents how the asymptotic convergence of Iterative Learning Control is combined with the closed-loop performance of Model Predictive Control to form a robust and asymptotically stable optimal controller for ensuring reliable and reproducible operation of batch processes....... This controller may also be used for Optimizing control. The modeling and control performance is demonstrated on a fed-batch protein cultivation example. The presented methodologies lend themselves directly for application as Process Analytical Technologies (PAT).......This contribution presents a systematic methodology for rapid acquirement of discrete-time state space model representations of batch processes based on their historical operation data. These state space models are parsimoniously parameterized as a set of local, interdependent models. The present...

  2. Self-management model in the scheduling of successive appointments in rheumatology.

    Science.gov (United States)

    Castro Corredor, David; Cuadra Díaz, José Luis; Mateos Rodríguez, Javier José; Anino Fernández, Joaquín; Mínguez Sánchez, María Dolores; de Lara Simón, Isabel María; Tébar, María Ángeles; Añó, Encarnación; Sanz, María Dolores; Ballester, María Nieves

    2018-01-08

    The rheumatology service of Ciudad Real Hospital, located in an autonomous community of that same name that is nearly in the center of Spain, implemented a self-management model of successive appointments more than 10 years ago. Since then, the physicians of the department schedule follow-up visits for their patients depending on the disease, its course and ancillary tests. The purpose of this study is to evaluate and compare the self-management model for successive appointments in the rheumatology service of Ciudad Real Hospital versus the model of external appointment management implemented in 8 of the hospital's 15 medical services. A comparative and multivariate analysis was performed to identify variables with statistically significant differences, in terms of activity and/or performance indicators and quality perceived by users. The comparison involved the self-management model for successive appointments employed in the rheumatology service of Ciudad Real Hospital and the model for external appointment management used in 8 hospital medical services between January 1 and May 31, 2016. In a database with more than 100,000 records of appointments involving the set of services included in the study, the mean waiting time and the numbers of non-appearances and rescheduling of follow-up visits in the rheumatology department were significantly lower than in the other services. The number of individuals treated in outpatient rheumatology services was 7,768, and a total of 280 patients were surveyed (response rate 63.21%). They showed great overall satisfaction, and the incidence rate of claims was low. Our results show that the self-management model of scheduling appointments has better results in terms of activity indicators and in quality perceived by users, despite the intense activity. Thus, this study could be fundamental for decision making in the management of health care organizations. Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de

  3. Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling.

    Science.gov (United States)

    Pimenta, A F R; Valente, A; Pereira, J M C; Pereira, J C F; Filipe, H P; Mata, J L G; Colaço, R; Saramago, B; Serro, A P

    2016-12-01

    Currently, most in vitro drug release studies for ophthalmic applications are carried out in static sink conditions. Although this procedure is simple and useful to make comparative studies, it does not describe adequately the drug release kinetics in the eye, considering the small tear volume and flow rates found in vivo. In this work, a microfluidic cell was designed and used to mimic the continuous, volumetric flow rate of tear fluid and its low volume. The suitable operation of the cell, in terms of uniformity and symmetry of flux, was proved using a numerical model based in the Navier-Stokes and continuity equations. The release profile of a model system (a hydroxyethyl methacrylate-based hydrogel (HEMA/PVP) for soft contact lenses (SCLs) loaded with diclofenac) obtained with the microfluidic cell was compared with that obtained in static conditions, showing that the kinetics of release in dynamic conditions is slower. The application of the numerical model demonstrated that the designed cell can be used to simulate the drug release in the whole range of the human eye tear film volume and allowed to estimate the drug concentration in the volume of liquid in direct contact with the hydrogel. The knowledge of this concentration, which is significantly different from that measured in the experimental tests during the first hours of release, is critical to predict the toxicity of the drug release system and its in vivo efficacy. In conclusion, the use of the microfluidic cell in conjunction with the numerical model shall be a valuable tool to design and optimize new therapeutic drug-loaded SCLs.

  4. Reproducibility of isotope ratio measurements

    International Nuclear Information System (INIS)

    Elmore, D.

    1981-01-01

    The use of an accelerator as part of a mass spectrometer has improved the sensitivity for measuring low levels of long-lived radionuclides by several orders of magnitude. However, the complexity of a large tandem accelerator and beam transport system has made it difficult to match the precision of low energy mass spectrometry. Although uncertainties for accelerator measured isotope ratios as low as 1% have been obtained under favorable conditions, most errors quoted in the literature for natural samples are in the 5 to 20% range. These errors are dominated by statistics and generally the reproducibility is unknown since the samples are only measured once

  5. Migration delays caused by anthropogenic barriers: modeling dams, temperature, and success on migrating salmon smolts

    Science.gov (United States)

    Marschall, Elizabeth A.; Mather, Martha E.; Parrish, Donna; Allison, Gary W.; McMenemy, James R.

    2011-01-01

    Disruption to migration is a growing problem for conservation and restoration of animal populations. Anthropogenic barriers along migration paths can delay or prolong migrations, which may result in a mismatch with migration-timing adaptations. To understand the interaction of dams (as barriers along a migration path), seasonally changing environmental conditions, timing of Atlantic salmon (Salmo salar) downstream migration, and ultimate migration success, we used 10 years of river temperature and discharge data as a template upon which we simulated downstream movement of salmon. Atlantic salmon is a cool-water species whose downstream migrating smolts must complete migration before river temperatures become too warm. We found that dams had a local effect on survival as well as a survival effect that was spatially and temporally removed from the encounter with the dam. While smolts are delayed by dams, temperatures downstream can reach lethal or near-lethal temperatures; as a result, the match between completion of migration and the window of appropriate migration conditions can be disrupted. The strength of this spatially and temporally removed effect is at least comparable to the local effects of dams in determining smolt migration success in the presence of dams. We also considered smolts from different tributaries, varying in distance from the river mouth, to assess the potential importance of locally adapted migration timing on the effect of barriers. Migration-initiation temperature affected modeled smolt survival differentially across tributaries, with the success of smolts from upstream tributaries being much more variable across years than that of smolts with a shorter distance to travel. As a whole, these results point to the importance of broadening our spatial and temporal view when managing migrating populations. We must consider not only how many individuals never make it across migration barriers, but also the spatially and temporally removed

  6. Migration delays caused by anthropogenic barriers: Modeling dams, temperature, and success of migrating salmon smolts

    Science.gov (United States)

    Marschall, E.A.; Mather, M. E.; Parrish, D.L.; Allison, G.W.; McMenemy, J.R.

    2011-01-01

    Disruption to migration is a growing problem for conservation and restoration of animal populations. Anthropogenic barriers along migration paths can delay or prolong migrations, which may result in a mismatch with migration-timing adaptations. To understand the interaction of dams (as barriers along a migration path), seasonally changing environmental conditions, timing of Atlantic salmon (Salmo salar) downstream migration, and ultimate migration success, we used 10 years of river temperature and discharge data as a template upon which we simulated downstream movement of salmon. Atlantic salmon is a cool-water species whose downstream migrating smolts must complete migration before river temperatures become too warm. We found that dams had a local effect on survival as well as a survival effect that was spatially and temporally removed from the encounter with the dam. While smolts are delayed by dams, temperatures downstream can reach lethal or near-lethal temperatures;as a result, the match between completion of migration and the window of appropriate migration conditions can be disrupted. The strength of this spatially and temporally removed effect is at least comparable to the local effects of dams in determining smolt migration success in the presence of dams. We also considered smolts from different tributaries, varying in distance from the river mouth, to assess the potential importance of locally adapted migration timing on the effect of barriers. Migration-initiation temperature affected modeled smolt survival differentially across tributaries, with the success of smolts from upstream tributaries being much more variable across years than that of smolts with a shorter distance to travel. As a whole, these results point to the importance of broadening our spatial and temporal view when managing migrating populations. We must consider not only how many individuals never make it across migration barriers, but also the spatially and temporally removed

  7. Designing for sustained adoption: A model of developing educational innovations for successful propagation

    Science.gov (United States)

    Khatri, Raina; Henderson, Charles; Cole, Renée; Froyd, Jeffrey E.; Friedrichsen, Debra; Stanford, Courtney

    2016-06-01

    [This paper is part of the Focused Collection on Preparing and Supporting University Physics Educators.] The physics education research community has produced a wealth of knowledge about effective teaching and learning of college level physics. Based on this knowledge, many research-proven instructional strategies and teaching materials have been developed and are currently available to instructors. Unfortunately, these intensive research and development activities have failed to influence the teaching practices of many physics instructors. This paper describes interim results of a larger study to develop a model of designing materials for successful propagation. The larger study includes three phases, the first two of which are reported here. The goal of the first phase was to characterize typical propagation practices of education developers, using data from a survey of 1284 National Science Foundation (NSF) principal investigators and focus group data from eight disciplinary groups of NSF program directors. The goal of the second phase was to develop an understanding of successful practice by studying three instructional strategies that have been well propagated. The result of the first two phases is a tentative model of designing for successful propagation, which will be further validated in the third phase through purposeful sampling of additional well-propagated instructional strategies along with typical education development projects. We found that interaction with potential adopters was one of the key missing ingredients in typical education development activities. Education developers often develop a polished product before getting feedback, rely on mass-market communication channels for dissemination, and do not plan for supporting adopters during implementation. The tentative model resulting from this study identifies three key propagation activities: interactive development, interactive dissemination, and support of adopters. Interactive development

  8. Predictive models of objective oropharyngeal OSA surgery outcomes: Success rate and AHI reduction ratio.

    Science.gov (United States)

    Choi, Ji Ho; Lee, Jae Yong; Cha, Jaehyung; Kim, Kangwoo; Hong, Seung-No; Lee, Seung Hoon

    2017-01-01

    The aim of this study was to develop a predictive model of objective oropharyngeal obstructive sleep apnea (OSA) surgery outcomes including success rate and apnea-hypopnea index (AHI) reduction ratio in adult OSA patients. Retrospective outcome research. All subjects with OSA who underwent oropharyngeal and/or nasal surgery and were followed for at least 3 months were enrolled in this study. Demographic, anatomical [tonsil size (TS) and palate-tongue position (PTP) grade (Gr)], and polysomnographic parameters were analyzed. The AHI reduction ratio (%) was defined as [(postoperative AHI-preoperative AHI) x 100 / postoperative AHI], and surgical success was defined as a ≥ 50% reduction in preoperative AHI with a postoperative AHI predictive equation by Forward Selection likelihood ratio (LR) logistic regression analysis was: [Formula: see text]The best predictive equation according to stepwise multiple linear regression analysis was: [Formula: see text] (TS/PTP Gr = 1 if TS/PTP Gr 3 or 4, TS/PTP Gr = 0 if TS/PTP Gr 1 or 2). The predictive models for oropharyngeal surgery described in this study may be useful for planning surgical treatments and improving objective outcomes in adult OSA patients.

  9. Modeling N Cycling during Succession after Forest Disturbance: an Analysis of N Mining and Retention Hypothesis

    Science.gov (United States)

    Zhou, Z.; Ollinger, S. V.; Ouimette, A.; Lovett, G. M.; Fuss, C. B.; Goodale, C. L.

    2017-12-01

    Dissolved inorganic nitrogen losses at the Hubbard Brook Experimental Forest (HBEF), New Hampshire, USA, have declined in recent decades, a pattern that counters expectations based on prevailing theory. An unbalanced ecosystem nitrogen (N) budget implies there is a missing component for N sink. Hypotheses to explain this discrepancy include increasing rates of denitrification and accumulation of N in mineral soil pools following N mining by plants. Here, we conducted a modeling analysis fused with field measurements of N cycling, specifically examining the hypothesis relevant to N mining and retention in mineral soils. We included simplified representations of both mechanisms, N mining and retention, in a revised ecosystem process model, PnET-SOM, to evaluate the dynamics of N cycling during succession after forest disturbance at the HBEF. The predicted N mining during the early succession was regulated by a metric representing a potential demand of extra soil N for large wood growth. The accumulation of nitrate in mineral soil pools was a function of the net aboveground biomass accumulation and soil N availability and parameterized based on field 15N tracer incubation data. The predicted patterns of forest N dynamics were consistent with observations. The addition of the new algorithms also improved the predicted DIN export in stream water with an R squared of 0.35 (Psuccession, and soil retention about 35% at the current forest stage at the HBEF.

  10. Predictive models of objective oropharyngeal OSA surgery outcomes: Success rate and AHI reduction ratio.

    Directory of Open Access Journals (Sweden)

    Ji Ho Choi

    Full Text Available The aim of this study was to develop a predictive model of objective oropharyngeal obstructive sleep apnea (OSA surgery outcomes including success rate and apnea-hypopnea index (AHI reduction ratio in adult OSA patients.Retrospective outcome research.All subjects with OSA who underwent oropharyngeal and/or nasal surgery and were followed for at least 3 months were enrolled in this study. Demographic, anatomical [tonsil size (TS and palate-tongue position (PTP grade (Gr], and polysomnographic parameters were analyzed. The AHI reduction ratio (% was defined as [(postoperative AHI-preoperative AHI x 100 / postoperative AHI], and surgical success was defined as a ≥ 50% reduction in preoperative AHI with a postoperative AHI < 20.A total of 156 consecutive OSAS adult patients (mean age ± SD = 38.9 ± 9.6, M / F = 149 / 7 were included in this study. The best predictive equation by Forward Selection likelihood ratio (LR logistic regression analysis was: [Formula: see text]The best predictive equation according to stepwise multiple linear regression analysis was: [Formula: see text] (TS/PTP Gr = 1 if TS/PTP Gr 3 or 4, TS/PTP Gr = 0 if TS/PTP Gr 1 or 2.The predictive models for oropharyngeal surgery described in this study may be useful for planning surgical treatments and improving objective outcomes in adult OSA patients.

  11. PSYCHOLOGY. Estimating the reproducibility of psychological science.

    Science.gov (United States)

    2015-08-28

    Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams. Copyright © 2015, American Association for the Advancement of Science.

  12. The NANOGrav Observing Program: Automation and Reproducibility

    Science.gov (United States)

    Brazier, Adam; Cordes, James; Demorest, Paul; Dolch, Timothy; Ferdman, Robert; Garver-Daniels, Nathaniel; Hawkins, Steven; Lam, Michael Timothy; Lazio, T. Joseph W.

    2018-01-01

    The NANOGrav Observing Program is a decades-long search for gravitational waves using pulsar timing which relies, for its sensitivity, on large data sets from observations of many pulsars. These are constructed through an intensive, long-term observing campaign. The nature of the program requires automation in the transfer and archiving of the large volume of raw telescope data, the calibration of those data, and making these resulting data products—required for diagnostic and data exploration purposes—available to NANOGrav members. Reproducibility of results is a key goal in this project, and essential to its success; it requires treating the software itself as a data product of the research, while ensuring easy access by, and collaboration between, members of NANOGrav, the International Pulsar Timing Array consortium (of which NANOGrav is a key member), as well as the wider astronomy community and the public.

  13. Uniform and reproducible stirring in a microbioreactor

    DEFF Research Database (Denmark)

    Bolic, Andrijana; Eliasson Lantz, Anna; Rottwitt, Karsten

    At present, research in bioprocess science and engineering increasingly requires fast and accurate analytical data (rapid testing) that can be used for investigation of the interaction between bioprocess operation conditions and the performance of the bioprocess. Miniaturization is certainly...... microbioreactor application. In order to address some of these questions, we are currently investigating and developing a microbioreactor platform with a reactor volume up to 1ml, as we believe that this volume is of interest to many industrial applications. It is widely known that stirring plays a very important...... role in achieving successful cultivations by promoting uniform process conditions and – for aerobic cultivations – a high oxygen transfer rate. In this contribution, the development of a suitable, reliable and reproducible stirrer in a microbioreactor for batch and continuous cultivation of S...

  14. Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: a useful in vitro model for testing new treatments.

    Science.gov (United States)

    Chamcheu, J C; Pihl-Lundin, I; Mouyobo, C E; Gester, T; Virtanen, M; Moustakas, A; Navsaria, H; Vahlquist, A; Törmä, H

    2011-02-01

    Epidermolytic ichthyosis (EI) is a skin fragility disorder caused by mutations in genes encoding suprabasal keratins 1 and 10. While the aetiology of EI is known, model systems are needed for pathophysiological studies and development of novel therapies. To generate immortalized keratinocyte lines from patients with EI for studies of EI cell pathology and the effects of chemical chaperones as putative therapies. We derived keratinocytes from three patients with EI and one healthy control and established immortalized keratinocytes using human papillomavirus 16-E6/E7. Growth and differentiation characteristics, ability to regenerate organotypic epidermis, keratin expression, formation of cytoskeletal aggregates, and responses to heat shock and chemical chaperones were assessed. The cell lines EH11 (K1_p.Val176_Lys197del), EH21 (K10_p.156Arg>Gly), EH31 (K10_p.Leu161_Asp162del) and NKc21 (wild-type) currently exceed 160 population doublings and differentiate when exposed to calcium. At resting state, keratin aggregates were detected in 9% of calcium-differentiated EH31 cells, but not in any other cell line. Heat stress further increased this proportion to 30% and also induced aggregates in 3% of EH11 cultures. Treatment with trimethylamine N-oxide and 4-phenylbutyrate (4-PBA) reduced the fraction of aggregate-containing cells and affected the mRNA expression of keratins 1 and 10 while 4-PBA also modified heat shock protein 70 (HSP70) expression. Furthermore, in situ proximity ligation assay suggested a colocalization between HSP70 and keratins 1 and 10. Reconstituted epidermis from EI cells cornified but EH21 and EH31 cells produced suprabasal cytolysis, closely resembling the in vivo phenotype. These immortalized cell lines represent a useful model for studying EI biology and novel therapies. © 2011 The Authors. BJD © 2011 British Association of Dermatologists.

  15. Selection of robust variables for transfer of classification models employing the successive projections algorithm.

    Science.gov (United States)

    Milanez, Karla Danielle Tavares Melo; Araújo Nóbrega, Thiago César; Silva Nascimento, Danielle; Galvão, Roberto Kawakami Harrop; Pontes, Márcio José Coelho

    2017-09-01

    Multivariate models have been widely used in analytical problems involving quantitative and qualitative analyzes. However, there are cases in which a model is not applicable to spectra of samples obtained under new experimental conditions or in an instrument not involved in the modeling step. A solution to this problem is the transfer of multivariate models, usually performed using standardization of the spectral responses or enhancement of the robustness of the model. This present paper proposes two new criteria for selection of robust variables for classification transfer employing the successive projections algorithm (SPA). These variables are then used to build models based on linear discriminant analysis (LDA) with low sensitivity with respect to the differences between the responses of the instruments involved. For this purpose, transfer samples are included in the calculation of the cost for each subset of variables under consideration. The proposed methods are evaluated for two case studies involving identification of adulteration of extra virgin olive oil (EVOO) and hydrated ethyl alcohol fuel (HEAF) using UV-Vis and NIR spectroscopy, respectively. In both cases, similar or better classification transfer results (obtained for a test set measured on the secondary instrument) employing the two criteria were obtained in comparison with direct standardization (DS) and piecewise direct standardization (PDS). For the UV-Vis data, both proposed criteria achieved the correct classification rate (CCR) of 85%, while the best CCR obtained for the standardization methods was 81% for DS. For the NIR data, 92.5% of CCR was obtained by both criteria as well as DS. The results demonstrated the possibility of using either of the criteria proposed for building robust models as an alternative to the standardization of spectral responses for transfer of classification. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. [Successful implementation of the EFQM management model at the Department of Ophthalmology in Graz].

    Science.gov (United States)

    Langmann, G; Maier, R; Theisl, A; Bauer, H; Klug, U; Foussek, C; Hödl, R; Wedrich, A; Gliebe, W

    2011-04-01

    In the context of legal requirements and scarcer resources, the implementation of a quality management (QM) model will provide a competitive advantage or a site warranty for a hospital. For 3 years, the Department of Ophthalmology in Graz has been working with the EFQM model and has now accomplished the first level quality award, namely "Committed to Excellence (C2E)". The project work towards achieving this C2E-award is described below. EFQM stands for European Foundation for Quality Management, an organization that was founded in 1989 by the EU, together with 14 leading enterprises. In the EFQM model, the maturity of an organization in terms of quality is determined through the achievement of a number of quality awards. The C2E award is the first of these awards. At the beginning of our work for the C2E level, the strengths and weaknesses of the Department of Ophthalmology were determined by means of an EFQM questionnaire. Three improvement measures with the highest impact on the performance of the clinic were identified by the questionnaire: 1. The hospitalization of a cataract patient. 2. The lack of information between the various professional parties. 3. The lack of knowledge within the professional groups of the objectives and strategy of the Department of Ophthalmology. These areas requiring improvement were targeted, addressed and improved in a 6-months project work, structured by the EFQM model. The project work as a whole, the results obtained and the corresponding written documentation were evaluated positively in a 1-day assessment by Quality Austria. The EFQM model is a challenging quality management model. After the necessary training of project members or under the supervision of experienced quality managers, the EFQM model may be successfully applied to patient care, teaching and research in a department of ophthalmology.

  17. A Mouse Model That Reproduces the Developmental Pathways and Site Specificity of the Cancers Associated With the Human BRCA1 Mutation Carrier State

    Directory of Open Access Journals (Sweden)

    Ying Liu

    2015-10-01

    Full Text Available Predisposition to breast and extrauterine Müllerian carcinomas in BRCA1 mutation carriers is due to a combination of cell-autonomous consequences of BRCA1 inactivation on cell cycle homeostasis superimposed on cell-nonautonomous hormonal factors magnified by the effects of BRCA1 mutations on hormonal changes associated with the menstrual cycle. We used the Müllerian inhibiting substance type 2 receptor (Mis2r promoter and a truncated form of the Follicle stimulating hormone receptor (Fshr promoter to introduce conditional knockouts of Brca1 and p53 not only in mouse mammary and Müllerian epithelia, but also in organs that control the estrous cycle. Sixty percent of the double mutant mice developed invasive Müllerian and mammary carcinomas. Mice carrying heterozygous mutations in Brca1 and p53 also developed invasive tumors, albeit at a lesser (30% rate, in which the wild type alleles were no longer present due to loss of heterozygosity. While mice carrying heterozygous mutations in both genes developed mammary tumors, none of the mice carrying only a heterozygous p53 mutation developed such tumors (P < 0.0001, attesting to a role for Brca1 mutations in tumor development. This mouse model is attractive to investigate cell-nonautonomous mechanisms associated with cancer predisposition in BRCA1 mutation carriers and to investigate the merit of chemo-preventive drugs targeting such mechanisms.

  18. Triple Diagonal modeling: A mechanism to focus productivity improvement for business success

    Energy Technology Data Exchange (ETDEWEB)

    Levine, L.O. [Pacific Northwest Lab., Richland, WA (United States); Villareal, L.D. [Army Depot, Corpus Christi, TX (United States)

    1993-09-01

    Triple Diagonal (M) modeling is a technique to help quickly diagnose an organization`s existing production system and to identify significant improvement opportunities in executing, controlling, and planning operations. TD modeling is derived from ICAM Definition Language (IDEF 0)-also known as Structured Analysis and Design Technique. It has been used successfully at several Department of Defense remanufacturing facilities trying to accomplish significant production system modernization. TD has several advantages over other modeling techniques. First, it quickly does ``As-ls`` analysis and then moves on to identify improvements. Second, creating one large diagram makes it easier to share the TD model throughout an organization, rather than the many linked 8 1/2 {times} 11`` drawings used in traditional decomposition approaches. Third, it acts as a communication mechanism to share understanding about improvement opportunities that may cross existing functional/organizational boundaries. Finally, TD acts as a vehicle to build a consensus on a prioritized list of improvement efforts that ``hangs togethers as an agenda for systemic changes in the production system and the improved integration of support functions.

  19. Hierarchical Bayesian Markov switching models with application to predicting spawning success of shovelnose sturgeon

    Science.gov (United States)

    Holan, S.H.; Davis, G.M.; Wildhaber, M.L.; DeLonay, A.J.; Papoulias, D.M.

    2009-01-01

    The timing of spawning in fish is tightly linked to environmental factors; however, these factors are not very well understood for many species. Specifically, little information is available to guide recruitment efforts for endangered species such as the sturgeon. Therefore, we propose a Bayesian hierarchical model for predicting the success of spawning of the shovelnose sturgeon which uses both biological and behavioural (longitudinal) data. In particular, we use data that were produced from a tracking study that was conducted in the Lower Missouri River. The data that were produced from this study consist of biological variables associated with readiness to spawn along with longitudinal behavioural data collected by using telemetry and archival data storage tags. These high frequency data are complex both biologically and in the underlying behavioural process. To accommodate such complexity we developed a hierarchical linear regression model that uses an eigenvalue predictor, derived from the transition probability matrix of a two-state Markov switching model with generalized auto-regressive conditional heteroscedastic dynamics. Finally, to minimize the computational burden that is associated with estimation of this model, a parallel computing approach is proposed. ?? Journal compilation 2009 Royal Statistical Society.

  20. Importance of prediction outlier diagnostics in determining a successful inter-vendor multivariate calibration model transfer.

    Science.gov (United States)

    Guenard, Robert D; Wehlburg, Christine M; Pell, Randy J; Haaland, David M

    2007-07-01

    This paper reports on the transfer of calibration models between Fourier transform near-infrared (FT-NIR) instruments from four different manufacturers. The piecewise direct standardization (PDS) method is compared with the new hybrid calibration method known as prediction augmented classical least squares/partial least squares (PACLS/PLS). The success of a calibration transfer experiment is judged by prediction error and by the number of samples that are flagged as outliers that would not have been flagged as such if a complete recalibration were performed. Prediction results must be acceptable and the outlier diagnostics capabilities must be preserved for the transfer to be deemed successful. Previous studies have measured the success of a calibration transfer method by comparing only the prediction performance (e.g., the root mean square error of prediction, RMSEP). However, our study emphasizes the need to consider outlier detection performance as well. As our study illustrates, the RMSEP values for a calibration transfer can be within acceptable range; however, statistical analysis of the spectral residuals can show that differences in outlier performance can vary significantly between competing transfer methods. There was no statistically significant difference in the prediction error between the PDS and PACLS/PLS methods when the same subset sample selection method was used for both methods. However, the PACLS/PLS method was better at preserving the outlier detection capabilities and therefore was judged to have performed better than the PDS algorithm when transferring calibrations with the use of a subset of samples to define the transfer function. The method of sample subset selection was found to make a significant difference in the calibration transfer results using the PDS algorithm, while the transfer results were less sensitive to subset selection when the PACLS/PLS method was used.

  1. The Impact of Positive Role Models on the Success of Students Involved in Original Scientific Research

    Science.gov (United States)

    Danch, J. M.

    2010-12-01

    To maximize student understanding of the methods of science via performance of authentic scientific research, a mentorship program for middle school students was developed for the 2010 - 2011 school year. A population of 8th grade science students will be selected from a district middle school and be paired with secondary student mentors already conducting individual research as part of a successful preexisting science research program. Students will interact with mentors in a school setting to develop and implement original scientific research projects. Upon completion, students will present their findings at an interscholastic science symposium and/or an in-district science symposium. Students will also receive support from professional scientists at the University of Medicine and Dentistry of New Jersey through interactive visitations and electronic communication. In an effort to provide diverse role models, mentors from a variety of racial, ethnic, and gender groups will participate. Student success will be evaluated through questionnaires, symposium participation and monitoring of future participation in authentic research programs as participants make the transition from middle to high school.

  2. A prognostic model to predict the success of artificial insemination in dairy cows based on readily available data

    NARCIS (Netherlands)

    Rutten, C.J.; Steeneveld, W.; Vernooij, J.C.M.; Huijps, K.; Nielen, M.; Hogeveen, H.

    2016-01-01

    A prognosis of the likelihood of insemination success is valuable information for the decision to start inseminating a cow. This decision is important for the reproduction management of dairy farms. The aim of this study was to develop a prognostic model for the likelihood of successful first

  3. A prognostic model to predict the success of artificial insemination in dairy cows based on readily available data

    NARCIS (Netherlands)

    Rutten, C J; Steeneveld, W; Vernooij, J C M; Huijps, K; Nielen, M; Hogeveen, H

    2016-01-01

    A prognosis of the likelihood of insemination success is valuable information for the decision to start inseminating a cow. This decision is important for the reproduction management of dairy farms. The aim of this study was to develop a prognostic model for the likelihood of successful first

  4. Using a micro-level model to generate a macro-level model of productive successful aging.

    Science.gov (United States)

    Johnson, Jessica K M; Sarkisian, Natalia; Williamson, John B

    2015-02-01

    Aging successfully entails good physical and cognitive health, as well as ongoing participation in social and productive activity. This study hones in on participation in productive activity, a factor that makes an important contribution to successful aging. One conceptual model of productive activity in later life specifies the antecedents and consequences of productivity. This study draws on that micro-level model to develop a corresponding macro-level model and assesses its utility for examining the predictors of and explaining the relationships between one form of productivity (labor force participation rates) and one aspect of well-being (average life expectancy) among males and females. Random effects regression models and path analysis were used to analyze cross-national longitudinal data for 24 high-income Organization for Economic Co-operation and Development (OECD) countries at seven time points (1980-2010; 168 observations total). OECD countries with higher labor force participation rates among older workers have higher life expectancies. Labor force participation mediates the effects of gross domestic product per capita on male and female life expectancy, and it mediates the effect of self-employment rate for men, but it acts as a suppressor with regard to the effect of public spending on male and female life expectancy. A well-known micro-level model of productive activity can be fruitfully adapted to account for macro-level cross-national variation in productivity and well-being. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  5. Modeling community succession and assembly: A novel method for network evolution

    Directory of Open Access Journals (Sweden)

    WenJun Zhang

    2012-06-01

    Full Text Available The process of modeling community succession and assembly is in some sense a method for network evolution, as done by Barabasi and Albert (1999. It is also one of the methods to create a sample networkfrom the statistic network I proposed earlier. I think that the mechanism of network evolution supposed by Barabasi and Albert is most likely applicable to the natural phenomena with emergency property. For natural phenomena without emergency property, the present study indicated that a scale-free network may be produced through a new mechanism, i.e., whether the connection of a taxon x occurs, dependent on the type and property of taxon y (in particular, the degree of its direct correlation with x to be connected but not necessarily the existing number of connections of taxon y, as proposed in present study.

  6. Putting patients first: a novel patient-centered model for medical enterprise success.

    Science.gov (United States)

    Dhawan, Naveen

    2014-01-01

    This article introduces a new way of viewing patient-customers. It encourages a greater emphasis on patients' needs and the importance of considering dimensions of the patient experience to better serve them. It also draws from examples in the general business world as they can be applied to medical enterprises. The author introduces a model that directs all business activities toward the end consumer with an underlying guidance by patient needs. A business is advised to understand its customer, design a patient-directed vision, and focus on creating a unique customer experience. The article delineates key action items for physicians and administrators that will allow them to better meet their patient-customers' needs and develop loyalty. By practicing a patient-centered approach and following these guidelines, one may ensure greater success of the medical enterprise.

  7. Commercial Contributions to the Success of the HEDS Enterprise: A Working Model

    Science.gov (United States)

    Nall, Mark; Askew, Ray

    2000-01-01

    The future of NASA involves the exploration of space beyond the confines of orbit about the Earth. This includes robotic investigations and Human Exploration and Development of Space (HEDS). The HEDS Strategic Plan states: "HEDS will join with the private sector to stimulate opportunities for commercial development in space as a key to future settlement. Near-term efforts will emphasize joint pilot projects that provide clear benefit to Earth from the development of near-Earth space." In support of this endeavor, NASA has established the Commercial Development of Space as a prime goal and is exploring all the ways in which NASA might make contributions to this development. NASA has long supported the development of space for commercial use. In 1985 it formally established and provided funds to support a program which created a number of joint ventures between universities and industry for this purpose. These were known as Centers for the Commercial Development of Space (CCDS). In 1999 NASA established a broader policy on commercialization with the aim of encouraging near-term commercial investment in conjunction with the International Space Station. Joint pilot projects will be initiated to stimulate this near-term investment. The long-term development of commercial concepts utilizing space access continues through the activities of the Commercial Space Centers (CSC), a sub-set of the original CCDS group. These Centers primarily require access to space for the conduct of their work. The remainder of the initial Centers focus on the development of tools and infrastructure to support users of the space environment. It is in this arena that long term development for commercial use and infrastructure development will occur. This paper will provide a retrospective examination of the Commercial Centers, the variety of models employed, the lessons learned, and the progress to date. This review will provide the bases for how successful models can be employed to accelerate

  8. Evaluation of the agonist PET radioligand [¹¹C]GR103545 to image kappa opioid receptor in humans: kinetic model selection, test-retest reproducibility and receptor occupancy by the antagonist PF-04455242.

    Science.gov (United States)

    Naganawa, Mika; Jacobsen, Leslie K; Zheng, Ming-Qiang; Lin, Shu-Fei; Banerjee, Anindita; Byon, Wonkyung; Weinzimmer, David; Tomasi, Giampaolo; Nabulsi, Nabeel; Grimwood, Sarah; Badura, Lori L; Carson, Richard E; McCarthy, Timothy J; Huang, Yiyun

    2014-10-01

    Kappa opioid receptors (KOR) are implicated in several brain disorders. In this report, a first-in-human positron emission tomography (PET) study was conducted with the potent and selective KOR agonist tracer, [(11)C]GR103545, to determine an appropriate kinetic model for analysis of PET imaging data and assess the test-retest reproducibility of model-derived binding parameters. The non-displaceable distribution volume (V(ND)) was estimated from a blocking study with naltrexone. In addition, KOR occupancy of PF-04455242, a selective KOR antagonist that is active in preclinical models of depression, was also investigated. For determination of a kinetic model and evaluation of test-retest reproducibility, 11 subjects were scanned twice with [(11)C]GR103545. Seven subjects were scanned before and 75 min after oral administration of naltrexone (150 mg). For the KOR occupancy study, six subjects were scanned at baseline and 1.5 h and 8 h after an oral dose of PF-04455242 (15 mg, n=1 and 30 mg, n=5). Metabolite-corrected arterial input functions were measured and all scans were 150 min in duration. Regional time-activity curves (TACs) were analyzed with 1- and 2-tissue compartment models (1TC and 2TC) and the multilinear analysis (MA1) method to derive regional volume of distribution (V(T)). Relative test-retest variability (TRV), absolute test-retest variability (aTRV) and intra-class coefficient (ICC) were calculated to assess test-retest reproducibility of regional VT. Occupancy plots were computed for blocking studies to estimate occupancy and V(ND). The half maximal inhibitory concentration (IC50) of PF-04455242 was determined from occupancies and drug concentrations in plasma. [(11)C]GR103545 in vivo K(D) was also estimated. Regional TACs were well described by the 2TC model and MA1. However, 2TC VT was sometimes estimated with high standard error. Thus MA1 was the model of choice. Test-retest variability was ~15%, depending on the outcome measure. The blocking

  9. Systematic heterogenization for better reproducibility in animal experimentation.

    Science.gov (United States)

    Richter, S Helene

    2017-08-31

    The scientific literature is full of articles discussing poor reproducibility of findings from animal experiments as well as failures to translate results from preclinical animal studies to clinical trials in humans. Critics even go so far as to talk about a "reproducibility crisis" in the life sciences, a novel headword that increasingly finds its way into numerous high-impact journals. Viewed from a cynical perspective, Fett's law of the lab "Never replicate a successful experiment" has thus taken on a completely new meaning. So far, poor reproducibility and translational failures in animal experimentation have mostly been attributed to biased animal data, methodological pitfalls, current publication ethics and animal welfare constraints. More recently, the concept of standardization has also been identified as a potential source of these problems. By reducing within-experiment variation, rigorous standardization regimes limit the inference to the specific experimental conditions. In this way, however, individual phenotypic plasticity is largely neglected, resulting in statistically significant but possibly irrelevant findings that are not reproducible under slightly different conditions. By contrast, systematic heterogenization has been proposed as a concept to improve representativeness of study populations, contributing to improved external validity and hence improved reproducibility. While some first heterogenization studies are indeed very promising, it is still not clear how this approach can be transferred into practice in a logistically feasible and effective way. Thus, further research is needed to explore different heterogenization strategies as well as alternative routes toward better reproducibility in animal experimentation.

  10. Schooling Immigrants in France in the 1990s: Success or Failure of the Republican Model of Integration?

    Science.gov (United States)

    van Zanten, Agnes

    1997-01-01

    A model relying on state institutions and schools for its transmission, the Republican model, has strongly influenced the perception and treatment of immigrants in France. An analysis of contemporary French schooling shows that the model is still producing cultural assimilation but is less successful in promoting the economic and social…

  11. Analysis of Success Factors to Implement Sustainable Supply Chain Management Using Interpretive Structural Modeling Technique: A Real Case Perspective

    Directory of Open Access Journals (Sweden)

    Mengke Yang

    2017-01-01

    Full Text Available Sustainability draws increased supply chain management (SCM attention. This article analyzes critical success to the assessment, evaluation, and attainment of sustainable supply chain management (SSCM, assessed through critical-success identification and qualitative data analysis. Namely, a literature review selected of 188 articles, published between January 1994 and November 2016, helps identify the most influential success factors. The qualitative data analysis pertains to fifteen such successes, identified in the literature review and through our collaboration with other academic researchers and industrial specialists. Notably, the study’s qualitative data analysis, interpretive structural modeling (ISM, unconceals the mutual impact among the most prominent SSCM success factors. The economic benefits and environmental awareness of suppliers are recognized as the most significant success factors, which could allow business enterprises and other organizations to implement a SSCM framework, with intentionality and the sustainability in their business. The article concludes with suggestions for future research directions.

  12. Incumbent Decisions about Succession Transitions in Family Firms: A Conceptual Model

    OpenAIRE

    Britta Boyd; Isabel C. Botero; Tomasz A. Fediuk

    2014-01-01

    In the family business literature, succession research has focused on the family member as they enter the leadership role or on the different issues that affect the succession process. Although researchers have acknowledged that succession in family businesses is “punctuated” by decision making events, less attention has been given to understanding how incumbents make decisions about ownership and management transitions. In an effort to continue to understand the succession process it is impo...

  13. A review of successful aging models: Proposing proactive coping as an important additional strategy

    NARCIS (Netherlands)

    Ouwehand, C.; Ridder, D.T.D. de; Bensing, J.

    2007-01-01

    Successful aging is an important concept, and one that has been the subject of much research. During the last 15 years, the emphasis of this research has shifted from formulating criteria for successful aging to describing the processes involved in successful aging. The main purpose of the present

  14. A review of successful aging models: proposing proactive coping as an important additional strategy.

    NARCIS (Netherlands)

    Ouwehand, C.; Ridder, D.T.D. de; Bensing, J.M.

    2007-01-01

    Successful aging is an important concept, and one that has been the subject of much research. During the last 15 years, the emphasis of this research has shifted from formulating criteria for successful aging to describing the processes involved in successful aging. The main purpose of the present

  15. A new strategy to deliver synthetic protein drugs: self-reproducible biologics using minicircles.

    Science.gov (United States)

    Yi, Hyoju; Kim, Youngkyun; Kim, Juryun; Jung, Hyerin; Rim, Yeri Alice; Jung, Seung Min; Park, Sung-Hwan; Ju, Ji Hyeon

    2014-08-05

    Biologics are the most successful drugs used in anticytokine therapy. However, they remain partially unsuccessful because of the elevated cost of their synthesis and purification. Development of novel biologics has also been hampered by the high cost. Biologics are made of protein components; thus, theoretically, they can be produced in vivo. Here we tried to invent a novel strategy to allow the production of synthetic drugs in vivo by the host itself. The recombinant minicircles encoding etanercept or tocilizumab, which are synthesized currently by pharmaceutical companies, were injected intravenously into animal models. Self-reproduced etanercept and tocilizumab were detected in the serum of mice. Moreover, arthritis subsided in mice that were injected with minicircle vectors carrying biologics. Self-reproducible biologics need neither factory facilities for drug production nor clinical processes, such as frequent drug injection. Although this novel strategy is in its very early conceptual stage, it seems to represent a potential alternative method for the delivery of biologics.

  16. A mental model for successful inter-disciplinary collaboration in curriculum innovation for information literacy

    Directory of Open Access Journals (Sweden)

    M. Detken Scheepers

    2011-01-01

    Full Text Available The University of Pretoria introduced a compulsory Information Literacy module to address the need for delivering motivated knowledgeable employees that embrace information and have the skills to find, select and use relevant information accurately, efficiently and effectively in an explosive information age. Low class attendance, an indication of unmotivated students, as well as the limited scholarly application of information literacy skills in consecutive academic years of study have been identified as possible barriers to the application of the desired skills. A collaborative action research project based on Whole Brain principles was introduced to motivate learners through innovative learning material in the module. A deeper understanding of the role of thinking preferences and thinking avoidances is essential in selecting a team that is responsible for the planning, design, development and delivery of learning opportunities and material. This article discusses the Whole Brain Model® as a mental model that underpins the successful collaboration of multidisciplinary teams and enhances innovative curriculum design that addresses alternative approaches to the teaching of Information Literacy.

  17. Analysis of behavioral intention on ABC system adoption: Model of information systems technology and success acceptance

    Directory of Open Access Journals (Sweden)

    Baiq Nensi Veni Indipenrian

    2015-12-01

    Full Text Available This study aims to examine the effect of individual behavioral change on the adoption of activity- based costing (ABC system and its usage, using Unified Theory of Accep-tance and Use of Technology (UTAUT and Information System Success Model. The sample involves 78 respondents who have positions as financial manager, controller manager, accounting manager, and production manager in mid-sized manufacturing companies in East java. The data were collected by survey method. This study used a Partial Least Square (PLS as the data analysis method. It was found that not all of the main UTAUT models were supported, because performance expectancy and effort expectancy have no effect on behavioral intention and use behavior to adopt ABC system. Whereas, social factors, information quality and facilitating conditions had a positive effect on behavioral intention and use behavior to adopt ABC system. The different results of this study with several previous studies are probably caused by the differences in the context of system, culture and characteristics of the sample. The implication of this study is not only to propose a theoretical framework for researches in future, but also useful for companies to optimize the use of ABC system that should be supported by top level and mid-level management and the readiness of the individu-als to accept the adoption of the ABC system.

  18. Conceptual Model of Successful Educational online Community of Practice for Kingdom of Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Fatimah Al-Shahrani

    2014-10-01

    Full Text Available The community of practice is an internet application that nourishes knowledge management and innovation. Implementing the community of practice in education can enhance the learning process and make it an enjoyable, exiting and lifelong experience. In this paper, the researchers intend to create a conceptual model for the successful implementation of community of practice in Education in the Kingdom of Saudi Arabia through evaluate the literature review about the educational community of practice. Then, a prototype is developed followed by a survey to collect feed-backs about the experiment. Using the Chi-Square statistical method of qualitative analysis associated with the Design Science Methodology of research, the research is fulfilled. The results illustrated the conceptual model of the effective implementation of the community of practice in the Kingdom of Saudi Arabia, that define the seven factors to be considered which are network density, culture perceptions, distributed production, knowledge complexity and richness, government enforcement, IT specialist role, and senior members role.

  19. Identifying critical success factors (CSFs) of implementing building information modeling (BIM) in Malaysian construction industry

    Science.gov (United States)

    Yaakob, Mazri; Ali, Wan Nur Athirah Wan; Radzuan, Kamaruddin

    2016-08-01

    Building Information Modeling (BIM) is defined as existing from the earliest concept to demolition and it involves creating and using an intelligent 3D model to inform and communicate project decisions. This research aims to identify the critical success factors (CSFs) of BIM implementation in Malaysian construction industry. A literature review was done to explore previous BIM studies on definitions and history of BIM, construction issues, application of BIM in construction projects as well as benefits of BIM. A series of interviews with multidisciplinary Malaysian construction experts will be conducted purposely for data collection process guided by the research design and methodology approach of this study. The analysis of qualitative data from the process will be combined with criteria identified in the literature review in order to identify the CSFs. Finally, the CSFs of BIM implementation will be validated by further Malaysian industrialists during a workshop. The validated CSFs can be used as a term of reference for both Malaysian practitioners and academics towards measuring BIM effectiveness level in their organizations.

  20. Modelling and monitoring vegetation and evapotranspiration on an anthropogenic grassland succession in the Andes of Ecuador

    Science.gov (United States)

    Silva, B.; Bendix, J.

    2012-04-01

    In the eastern Andes of southern Ecuador the infestation of pasture (mostly C4-grass Setaria sphacelata) by the aggressive bracken fern (Pteridium sp.) still is an unsolved problem. Environmental and exogenous factors and direct plant competition have been hypothesized to drive bracken occurrence. Special attention is given to pasture burning, which stimulates bracken growth, and is common in the relative dry season (Oct-Dec). However, no knowledge is available for a quantitative hypothesis investigation on bracken occurrence under current and future local climate. In this work a modeling approach is presented, in which initial investigations support the application of a two-big-leaf model, and parameterization and model forcing are made with extensive data on physiological traits and on the physical environment. Our main aims here are (i) to show field investigations on a plant scale, which are the basis for a proper model parameterization; and (ii) to provide initialization data, which is based on estimation of green leaf area index from very-high and high resolution optical remote sensing (air-photos and Quickbird images); (iii) to simulate vegetation succession after burn on an experimental site, using in situ climate data and future climate-change scenarios. The modeling approach is based in the main on the vegetation dynamic model called Southern Bracken Competition Model (SoBraCoMo), which has been coupled to a hydrological model written on the catchment model framework (CMF), to simulate soil-vegetation dynamics. Main initialization variables are biochemical parameters (quantum and carboxylation efficiency) and the green leaf area index (green-LAI). Forcing data include soil, leaf and air temperature, soil and air humidity and radiation. The model has been developed and tested on the experimental site (2100 m asl) in the Rio San Francisco Valley, Ecuador. Simulation results on the burn experiment of 2009 showed that stimulation by fire could not boost fern

  1. Reproducibility in Research: Systems, Infrastructure, Culture

    Directory of Open Access Journals (Sweden)

    Tom Crick

    2017-11-01

    Full Text Available The reproduction and replication of research results has become a major issue for a number of scientific disciplines. In computer science and related computational disciplines such as systems biology, the challenges closely revolve around the ability to implement (and exploit novel algorithms and models. Taking a new approach from the literature and applying it to a new codebase frequently requires local knowledge missing from the published manuscripts and transient project websites. Alongside this issue, benchmarking, and the lack of open, transparent and fair benchmark sets present another barrier to the verification and validation of claimed results. In this paper, we outline several recommendations to address these issues, driven by specific examples from a range of scientific domains. Based on these recommendations, we propose a high-level prototype open automated platform for scientific software development which effectively abstracts specific dependencies from the individual researcher and their workstation, allowing easy sharing and reproduction of results. This new e-infrastructure for reproducible computational science offers the potential to incentivise a culture change and drive the adoption of new techniques to improve the quality and efficiency – and thus reproducibility – of scientific exploration.

  2. Electoral entry and success of ethnic minority parties in central and eastern Europe: A hierarchical selection model

    DEFF Research Database (Denmark)

    Bernauer, Julian; Bochsler, Daniel

    2011-01-01

    The paper examines determinants of electoral entry and success of ethnic minority parties in central and eastern Europe. The application of a hierarchical selection model shows that the strategic entry of minority parties depends on their expected electoral success due both to observed...... and unobserved factors. Drawing on formal models of electoral entry, the electoral success of new (or niche) parties is expected to be influenced by the costs of entry (determined by electoral thresholds) and the potential for electoral support. The latter depends on the reactions of political competitors...... and electoral demand, measured here as the size of ethnic groups and the saliency of ethnic issues. In line with these expectations, parties only run if they can expect electoral support sufficient to pass the electoral threshold. This finding would have been overlooked by a na??ve model of electoral success...

  3. The Model for Understanding Success in Quality (MUSIQ): building a theory of context in healthcare quality improvement.

    Science.gov (United States)

    Kaplan, Heather C; Provost, Lloyd P; Froehle, Craig M; Margolis, Peter A

    2012-01-01

    BACKGROUND Quality improvement (QI) efforts have become widespread in healthcare, however there is significant variability in their success. Differences in context are thought to be responsible for some of the variability seen. To develop a conceptual model that can be used by organisations and QI researchers to understand and optimise contextual factors affecting the success of a QI project. 10 QI experts were provided with the results of a systematic literature review and then participated in two rounds of opinion gathering to identify and define important contextual factors. The experts subsequently met in person to identify relationships among factors and to begin to build the model. The Model for Understanding Success in Quality (MUSIQ) is organised based on the level of the healthcare system and identifies 25 contextual factors likely to influence QI success. Contextual factors within microsystems and those related to the QI team are hypothesised to directly shape QI success, whereas factors within the organisation and external environment are believed to influence success indirectly. The MUSIQ framework has the potential to guide the application of QI methods in healthcare and focus research. The specificity of MUSIQ and the explicit delineation of relationships among factors allows a deeper understanding of the mechanism of action by which context influences QI success. MUSIQ also provides a foundation to support further studies to test and refine the theory and advance the field of QI science.

  4. Developing and validating a model to predict the success of an IHCS implementation: the Readiness for Implementation Model

    Science.gov (United States)

    Gustafson, David H; Hawkins, Robert P; Brennan, Patricia F; Dinauer, Susan; Johnson, Pauley R; Siegler, Tracy

    2010-01-01

    Objective To develop and validate the Readiness for Implementation Model (RIM). This model predicts a healthcare organization's potential for success in implementing an interactive health communication system (IHCS). The model consists of seven weighted factors, with each factor containing five to seven elements. Design Two decision-analytic approaches, self-explicated and conjoint analysis, were used to measure the weights of the RIM with a sample of 410 experts. The RIM model with weights was then validated in a prospective study of 25 IHCS implementation cases. Measurements Orthogonal main effects design was used to develop 700 conjoint-analysis profiles, which varied on seven factors. Each of the 410 experts rated the importance and desirability of the factors and their levels, as well as a set of 10 different profiles. For the prospective 25-case validation, three time-repeated measures of the RIM scores were collected for comparison with the implementation outcomes. Results Two of the seven factors, ‘organizational motivation’ and ‘meeting user needs,’ were found to be most important in predicting implementation readiness. No statistically significant difference was found in the predictive validity of the two approaches (self-explicated and conjoint analysis). The RIM was a better predictor for the 1-year implementation outcome than the half-year outcome. Limitations The expert sample, the order of the survey tasks, the additive model, and basing the RIM cut-off score on experience are possible limitations of the study. Conclusion The RIM needs to be empirically evaluated in institutions adopting IHCS and sustaining the system in the long term. PMID:20962135

  5. Developing a theoretical model and questionnaire survey instrument to measure the success of electronic health records in residential aged care

    Science.gov (United States)

    Yu, Ping; Qian, Siyu

    2018-01-01

    Electronic health records (EHR) are introduced into healthcare organizations worldwide to improve patient safety, healthcare quality and efficiency. A rigorous evaluation of this technology is important to reduce potential negative effects on patient and staff, to provide decision makers with accurate information for system improvement and to ensure return on investment. Therefore, this study develops a theoretical model and questionnaire survey instrument to assess the success of organizational EHR in routine use from the viewpoint of nursing staff in residential aged care homes. The proposed research model incorporates six variables in the reformulated DeLone and McLean information systems success model: system quality, information quality, service quality, use, user satisfaction and net benefits. Two variables training and self-efficacy were also incorporated into the model. A questionnaire survey instrument was designed to measure the eight variables in the model. After a pilot test, the measurement scale was used to collect data from 243 nursing staff members in 10 residential aged care homes belonging to three management groups in Australia. Partial least squares path modeling was conducted to validate the model. The validated EHR systems success model predicts the impact of the four antecedent variables—training, self-efficacy, system quality and information quality—on the net benefits, the indicator of EHR systems success, through the intermittent variables use and user satisfaction. A 24-item measurement scale was developed to quantitatively evaluate the performance of an EHR system. The parsimonious EHR systems success model and the measurement scale can be used to benchmark EHR systems success across organizations and units and over time. PMID:29315323

  6. Developing a theoretical model and questionnaire survey instrument to measure the success of electronic health records in residential aged care.

    Science.gov (United States)

    Yu, Ping; Qian, Siyu

    2018-01-01

    Electronic health records (EHR) are introduced into healthcare organizations worldwide to improve patient safety, healthcare quality and efficiency. A rigorous evaluation of this technology is important to reduce potential negative effects on patient and staff, to provide decision makers with accurate information for system improvement and to ensure return on investment. Therefore, this study develops a theoretical model and questionnaire survey instrument to assess the success of organizational EHR in routine use from the viewpoint of nursing staff in residential aged care homes. The proposed research model incorporates six variables in the reformulated DeLone and McLean information systems success model: system quality, information quality, service quality, use, user satisfaction and net benefits. Two variables training and self-efficacy were also incorporated into the model. A questionnaire survey instrument was designed to measure the eight variables in the model. After a pilot test, the measurement scale was used to collect data from 243 nursing staff members in 10 residential aged care homes belonging to three management groups in Australia. Partial least squares path modeling was conducted to validate the model. The validated EHR systems success model predicts the impact of the four antecedent variables-training, self-efficacy, system quality and information quality-on the net benefits, the indicator of EHR systems success, through the intermittent variables use and user satisfaction. A 24-item measurement scale was developed to quantitatively evaluate the performance of an EHR system. The parsimonious EHR systems success model and the measurement scale can be used to benchmark EHR systems success across organizations and units and over time.

  7. Incumbent Decisions about Succession Transitions in Family Firms: A Conceptual Model

    Directory of Open Access Journals (Sweden)

    Britta Boyd

    2014-11-01

    Full Text Available In the family business literature, succession research has focused on the family member as they enter the leadership role or on the different issues that affect the succession process. Although researchers have acknowledged that succession in family businesses is “punctuated” by decision making events, less attention has been given to understanding how incumbents make decisions about ownership and management transitions. In an effort to continue to understand the succession process it is important to understand how incumbents make decisions about the type of transitions they intend to engage in (i.e., intra-family succession, out of family succession, or no succession. Building on the theory of planned behavior and the socioemotional wealth framework (SEW, this manuscript presents a conceptual framework to understand the factors that influence succession transitions and the role that contextual factors can play in this decision-making process. We present theory driven propositions and discuss the implications for understanding and evaluation of the succession process.

  8. Toward establishing model organisms for marine protists: Successful transfection protocols for Parabodo caudatus (Kinetoplastida: Excavata).

    Science.gov (United States)

    Gomaa, Fatma; Garcia, Paulo A; Delaney, Jennifer; Girguis, Peter R; Buie, Cullen R; Edgcomb, Virginia P

    2017-09-01

    We developed protocols for, and demonstrated successful transfection of, the free-living kinetoplastid flagellate Parabodo caudatus with three plasmids carrying a fluorescence reporter gene (pEF-GFP with the EF1 alpha promoter, pUB-GFP with Ubiquitin C promoter, and pEYFP-Mitotrap with CMV promoter). We evaluated three electroporation approaches: (1) a square-wave electroporator designed for eukaryotes, (2) a novel microfluidic transfection system employing hydrodynamically-controlled electric field waveforms, and (3) a traditional exponential decay electroporator. We found the microfluidic device provides a simple and efficient platform to quickly test a wide range of electric field parameters to find the optimal set of conditions for electroporation of target species. It also allows for processing large sample volumes (>10 ml) within minutes, increasing throughput 100 times over cuvettes. Fluorescence signal from the reporter gene was detected a few hours after transfection and persisted for 3 days in cells transfected by pEF-GFP and pUB-GFP plasmids and for at least 5 days post-transfection for cells transfected with pEYFP-Mitotrap. Expression of the reporter genes (GFP and YFP) was also confirmed using reverse transcription-PCR (RT-PCR). This work opens the door for further efforts with this taxon and close relatives toward establishing model systems for genome editing. © 2017 Society for Applied Microbiology and John Wiley & Sons Ltd.

  9. The cardiovascular perfusionist as a model for the successful technologist in high stress situations.

    Science.gov (United States)

    Friday, P J; Mook, W J

    1991-01-01

    This study investigates the psychological profiles of highly stressed medical technologists. One hundred and four individuals representing a cross-section of the United States who function as operators of heart-lung machines during open heart surgery (perfusionists) were studied using both internal and external models based on the works of Eric Berne and Karen Horney. Daily exposure to life and death responsibilities combined with the constant pressures of maintaining current technical skills can make the profession selected for this study representative of high technology professions that require a great deal of coping. Results of this study indicate that there is a balanced psychological profile in successful technologists functioning in long-term, high-stressed occupations. Female perfusionists appear to be more aggressive and critical than their male counterparts. This is seen as an attempt by female perfusionists to compensate for what has historically been a male dominanted, highly technical and high-stressed occupation. Generalizations for candidate selections to high stressed occupations could be made as well as projections of foundations for possible progressive disillusionment (burn out).

  10. A Statewide Model for Assisting Nursing Home Residents to Transition Successfully to the Community

    Directory of Open Access Journals (Sweden)

    Darci Buttke

    2018-04-01

    Full Text Available Minnesota’s Return to Community Initiative (RTCI is a novel, statewide initiative to assist private paying nursing home residents to return to the community and to remain in that setting without converting to Medicaid. The objective of this manuscript is to describe in detail RTCI’s development and design, its key operational components, and characteristics of its clients and their care outcomes. Data on client characteristics and outcomes come from the Minimum Data Set, staff assessments of clients and caregivers, and Medicaid eligibility files. Most clients transitioned by the RTCI had entered the nursing facility from a hospital. Clients overwhelmingly wanted to return to the community and fit a health and functional profile making them good candidates for community discharge. Most clients went to a private residence, living alone or with a spouse; yet, adult children were the most frequent caregivers. At one year of follow-up 76% of individuals were alive and living in the community and only a small percentage (8.2% had converted to Medicaid. The RTCI holds promise as a successful model for states to adopt in assisting individuals who are at risk to become long stay nursing home residents instead to return to the community.

  11. Is Russia successful in attracting foreign direct investment? Evidence based on gravity model estimation

    Directory of Open Access Journals (Sweden)

    Mariev Oleg

    2016-09-01

    Full Text Available The aim of this paper is twofold. First, it is to answer the question of whether Russia is successful in attracting foreign direct investment (FDI. Second, it is to identify partner countries that “overinvest” and “underinvest” in the Russian economy. We do this by calculating potential FDI inflows to Russia and comparing them with actual values. This research is associated with the empirical estimation of factors explaining FDI flows between countries. The methodological foundation used for the research is the gravity model of foreign direct investment. In discussing the pros and cons of different econometric methods of the estimation gravity equation, we conclude that the Poisson pseudo maximum likelihood method with instrumental variables (IV PPML is one of the best options in our case. Using a database covering about 70% of FDI flows for the period of 2001-2011, we discover the following factors that explain the variance of bilateral FDI flows in the world economy: GDP value of investing country, GDP value of recipient country, distance between countries, remoteness of investor country, remoteness of recipient country, level of institutions development in host country, wage level in host country, membership of two countries in a regional economic union, common official language, common border and colonial relationships between countries in the past. The potential values of FDI inflows are calculated using coefficients of regressors from the econometric model. We discover that the Russian economy performs very well in attracting FDI: the actual FDI inflows exceed potential values by 1.72 times. Large developed countries (France, Germany, UK, Italy overinvest in the Russian economy, while smaller and less developed countries (Czech Republic, Belarus, Denmark, Ukraine underinvest in Russia. Countries of Southeast Asia (China, South Korea, Japan also underinvest in the Russian economy.

  12. LANDIS 4.0 users guide. LANDIS: a spatially explicit model of forest landscape disturbance, management, and succession

    Science.gov (United States)

    Hong S. He; Wei Li; Brian R. Sturtevant; Jian Yang; Bo Z. Shang; Eric J. Gustafson; David J. Mladenoff

    2005-01-01

    LANDIS 4.0 is new-generation software that simulates forest landscape change over large spatial and temporal scales. It is used to explore how disturbances, succession, and management interact to determine forest composition and pattern. Also describes software architecture, model assumptions and provides detailed instructions on the use of the model.

  13. Toward a Predictive Model of Community College Student Success in Blended Classes

    Science.gov (United States)

    Volchok, Edward

    2018-01-01

    This retrospective study evaluates early semester predictors of whether or not community college students will successfully complete blended or hybrid courses. These predictors are available to faculty by the fourth week of the semester. Success is defined as receiving a grade of C- or higher. Failure is defined as a grade below a C- or a…

  14. The importance of a precise definition, comprehensive model, and critical discussion of successful aging at work

    NARCIS (Netherlands)

    Zacher, Hannes

    2015-01-01

    It is crucial to advance understanding of the concept of successful aging at work to guide rigorous future research and effective practice. Drawing on the gerontology and life-span developmental literatures, I recently proposed a definition and theoretical framework of successful aging at work that

  15. Treatment of Events Representing System Success in Accident Sequences in PSA Models with ET/FT Linking

    International Nuclear Information System (INIS)

    Vrbanic, I.; Spiler, J.; Mikulicic, V.; Simic, Z.

    2002-01-01

    Treatment of events that represent systems' successes in accident sequences is well known issue associated primarily with those PSA models that employ event tree / fault tree (ET / FT) linking technique. Even theoretically clear, practical implementation and usage creates for certain PSA models a number of difficulties regarding result correctness. Strict treatment of success-events would require consistent applying of de Morgan laws. However, there are several problems related to it. First, Boolean resolution of the overall model, such as the one representing occurrence of reactor core damage, becomes very challenging task if De Morgan rules are applied consistently at all levels. Even PSA tools of the newest generation have some problems with performing such a task in a reasonable time frame. The second potential issue is related to the presence of negated basic events in minimal cutsets. If all the basic events that result from strict applying of De Morgan rules are retained in presentation of minimal cutsets, their readability and interpretability may be impaired severely. It is also worth noting that the concept of a minimal cutset is tied to equipment failures, rather than to successes. For reasons like these, various simplifications are employed in PSA models and tools, when it comes to the treatment of success-events in the sequences. This paper provides a discussion of major concerns associated with the treatment of success-events in accident sequences of a typical PSA model. (author)

  16. Theory of reproducing kernels and applications

    CERN Document Server

    Saitoh, Saburou

    2016-01-01

    This book provides a large extension of the general theory of reproducing kernels published by N. Aronszajn in 1950, with many concrete applications. In Chapter 1, many concrete reproducing kernels are first introduced with detailed information. Chapter 2 presents a general and global theory of reproducing kernels with basic applications in a self-contained way. Many fundamental operations among reproducing kernel Hilbert spaces are dealt with. Chapter 2 is the heart of this book. Chapter 3 is devoted to the Tikhonov regularization using the theory of reproducing kernels with applications to numerical and practical solutions of bounded linear operator equations. In Chapter 4, the numerical real inversion formulas of the Laplace transform are presented by applying the Tikhonov regularization, where the reproducing kernels play a key role in the results. Chapter 5 deals with ordinary differential equations; Chapter 6 includes many concrete results for various fundamental partial differential equations. In Chapt...

  17. A prognostic model to predict the success of artificial insemination in dairy cows based on readily available data.

    Science.gov (United States)

    Rutten, C J; Steeneveld, W; Vernooij, J C M; Huijps, K; Nielen, M; Hogeveen, H

    2016-08-01

    A prognosis of the likelihood of insemination success is valuable information for the decision to start inseminating a cow. This decision is important for the reproduction management of dairy farms. The aim of this study was to develop a prognostic model for the likelihood of successful first insemination. The parameters considered for the model are readily available on farm at the time a farmer makes breeding decisions. In the first step, variables are selected for the prognostic model that have prognostic value for the likelihood of a successful first insemination. In the second step, farm effects on the likelihood of a successful insemination are quantified and the prognostic model is cross-validated. Logistic regression with a random effect for farm was used to develop the prognostic model. Insemination and test-day milk production data from 2,000 commercial Dutch dairy farms were obtained, and 190,541 first inseminations from this data set were used for model selection. The following variables were used in the selection process: parity, days in milk, days to peak production, production level relative to herd mates, milk yield, breed of the cow, insemination season and calving season, log of the ratio of fat to protein content, and body condition score at insemination. Variables were selected in a forward selection and backward elimination, based on the Akaike information criterion. The variables that contributed most to the model were random farm effect, relative production factor, and milk yield at insemination. The parameters were estimated in a bootstrap analysis and a cross-validation was conducted within this bootstrap analysis. The parameter estimates for body condition score at insemination varied most, indicating that this effect varied most among Dutch dairy farms. The cross-validation showed that the prognosis of insemination success closely resembled the mean insemination success observed in the data set. Insemination success depends on

  18. Aerosol effects on cloud water amounts were successfully simulated by a global cloud-system resolving model.

    Science.gov (United States)

    Sato, Yousuke; Goto, Daisuke; Michibata, Takuro; Suzuki, Kentaroh; Takemura, Toshihiko; Tomita, Hirofumi; Nakajima, Teruyuki

    2018-03-07

    Aerosols affect climate by modifying cloud properties through their role as cloud condensation nuclei or ice nuclei, called aerosol-cloud interactions. In most global climate models (GCMs), the aerosol-cloud interactions are represented by empirical parameterisations, in which the mass of cloud liquid water (LWP) is assumed to increase monotonically with increasing aerosol loading. Recent satellite observations, however, have yielded contradictory results: LWP can decrease with increasing aerosol loading. This difference implies that GCMs overestimate the aerosol effect, but the reasons for the difference are not obvious. Here, we reproduce satellite-observed LWP responses using a global simulation with explicit representations of cloud microphysics, instead of the parameterisations. Our analyses reveal that the decrease in LWP originates from the response of evaporation and condensation processes to aerosol perturbations, which are not represented in GCMs. The explicit representation of cloud microphysics in global scale modelling reduces the uncertainty of climate prediction.

  19. "Grey nomads" in Australia: are they a good model for successful aging and health?

    Science.gov (United States)

    Higgs, Paul F D; Quirk, Frances

    2007-10-01

    Lifestyle factors have been identified as being very important in determining health in later life. Nutrition, exercise, and social environment all interact to promote, or to limit, opportunities for an active and healthy post-working life. Not only are rates of chronic illness and disability reduced through the promotion of healthy lifestyles, but also quality of life is maintained through the compression of morbidity. Governments in Australia, as in the European Union and North America, have highlighted the importance of behavioral change in health promotion strategies with the aim of having an impact on the health-related lifestyles of their populations. This paper examines the example of a group of older Australians, the "grey nomads," who may present opportunities for examining health-related lifestyle changes. The term grey nomad refers to a portion of the older population in Australia who choose to use their later years and retirement as opportunities for travel and leisure, mainly within the confines of the Australian continent. As such, they are similar to groups in North America, such as the "snow birds," who travel to the southern United States to escape the colder winters of more northerly latitudes. Similar seasonal migrations occur from Northern to Southern Europe. What all share in common is an active culture/lifestyle of attempting to "age successfully." Grey nomads also participate in the creation of what can be termed postmodern communities, where they and other regular travelers may develop a sense of community feeling with others who are also regularly returning to the same spot year after year. Social support is highly predictive of health outcomes and such mobile communities may prove a positive factor in promoting good health. In this paper we examine whether the "grey nomads" represent a good model for improving health-related lifestyles in later life.

  20. Maximum Potential Score (MPS: An operating model for a successful customer-focused strategy.

    Directory of Open Access Journals (Sweden)

    Cabello González, José Manuel

    2015-12-01

    Full Text Available One of marketers’ chief objectives is to achieve customer loyalty, which is a key factor for profitable growth. Therefore, they need to develop a strategy that attracts and maintains customers, giving them adequate motives, both tangible (prices and promotions and intangible (personalized service and treatment, to satisfy a customer and make him loyal to the company. Finding a way to accurately measure satisfaction and customer loyalty is very important. With regard to typical Relationship Marketing measures, we can consider listening to customers, which can help to achieve a competitive sustainable advantage. Customer satisfaction surveys are essential tools for listening to customers. Short questionnaires have gained considerable acceptance among marketers as a means to achieve a customer satisfaction measure. Our research provides an indication of the benefits of a short questionnaire (one/three questions. We find that the number of questions survey is significantly related to the participation in the survey (Net Promoter Score or NPS. We also prove that a the three question survey is more likely to have more participants than a traditional survey (Maximum Potential Score or MPS . Our main goal is to analyse one method as a potential predictor of customer loyalty. Using surveys, we attempt to empirically establish the causal factors in determining the satisfaction of customers. This paper describes a maximum potential operating model that captures with a three questions survey, important elements for a successful customer-focused strategy. MPS may give us lower participation rates than NPS but important information that helps to convert unhappy customers or just satisfied customers, into loyal customers.

  1. The organizational structure and group the following criteria in assessing the success of the model construction companies

    Directory of Open Access Journals (Sweden)

    Đurović Dušan D.

    2016-01-01

    Full Text Available The organization - an organizational structure presents a schedule of all the potential companies covering all human and material resources in the enterprise, which ensure the realization of business goals in function of their success. Defining the process, the use of SWOT analysis and evaluation of success using appropriate models condition and promote the role of the organization in a construction company. This article is an excerpt from the research within relevant doctoral dissertation [5] and displays the result of the evaluation of business performance of construction companies applying AHP model.

  2. DEVELOPING A CONCEPTUAL INFORMATION SYSTEMS (IS) SUCCESS MODEL FOR INTELLIGENT VEHICLE TRACKING SYSTEMS USED IN DEVELOPING COUNTRIES – THE CASE OF GHANA

    DEFF Research Database (Denmark)

    Adjin, Daniel Michael Okwabi

    This research developed a conceptual Information Systems (IS) success model to address problems of Intelligent Vehicle Tracking Systems (IVTS) in developing countries – the, case of Ghana. The study was based on existing IS Success Models used in measuring the performance, usefulness...... core theoretical IS concepts required to develop the conceptual IS success model. Research Outcome: the proposed conceptual IS Success Model is developed; has considerably extended the updated DeLone & McLean (2003) IS success model; making it possible to apply IS success model to evaluate...... and successfulness of information systems applicable to IVTS success evaluation. Problems addressed: users of IVTS in developing countries, especially in Ghana, are dissatisfied with the performances of IVTS and services, regarding system & service qualities, information quality, low user-perceptions, low system...

  3. ANALYSIS OF INFORMATION SYSTEM IMPLEMENTATION IN BINUS UNIVERSITY USING DELONE AND MCLEAN INFORMATION SYSTEM SUCCESS MODEL AND COBIT FRAMEWORK

    Directory of Open Access Journals (Sweden)

    Johan Muliadi Kerta

    2013-05-01

    Full Text Available The success of implementation of information system in an organization will supportthe organization in the process of achieving goals. Successful information system will support theorganization's day-to-day operations, so that problem can be resolved more quickly and easily. Theinformation system which has been developed and implemented is also necessary to measure thematurity level. Therefore, it can determine whether the implementation of information systemsmade in accordance with the goals of the organization. Measuring the success of informationsystems used the DeLone and McLean IS success model. To measure the maturity level ofinformation systems used COBIT (Control Objectives for Information and related Technologyframeworks that provides best practices for IT governance and control. The results of this analysiswill assist and support the IT team in order to develop and build information systems that better fitthe needs and goals of the organization.

  4. Reproducibility of surface roughness in reaming

    DEFF Research Database (Denmark)

    Müller, Pavel; De Chiffre, Leonardo

    An investigation on the reproducibility of surface roughness in reaming was performed to document the applicability of this approach for testing cutting fluids. Austenitic stainless steel was used as a workpiece material and HSS reamers as cutting tools. Reproducibility of the results was evaluat...

  5. Examination of reproducibility in microbiological degredation experiments

    DEFF Research Database (Denmark)

    Sommer, Helle Mølgaard; Spliid, Henrik; Holst, Helle

    1998-01-01

    Experimental data indicate that certain microbiological degradation experiments have a limited reproducibility. Nine identical batch experiments were carried out on 3 different days to examine reproducibility. A pure culture, isolated from soil, grew with toluene as the only carbon and energy...

  6. Reproducible statistical analysis with multiple languages

    DEFF Research Database (Denmark)

    Lenth, Russell; Højsgaard, Søren

    2011-01-01

    This paper describes the system for making reproducible statistical analyses. differs from other systems for reproducible analysis in several ways. The two main differences are: (1) Several statistics programs can be in used in the same document. (2) Documents can be prepared using OpenOffice or ...

  7. Reproducibility principles, problems, practices, and prospects

    CERN Document Server

    Maasen, Sabine

    2016-01-01

    Featuring peer-reviewed contributions from noted experts in their fields of research, Reproducibility: Principles, Problems, Practices, and Prospects presents state-of-the-art approaches to reproducibility, the gold standard sound science, from multi- and interdisciplinary perspectives. Including comprehensive coverage for implementing and reflecting the norm of reproducibility in various pertinent fields of research, the book focuses on how the reproducibility of results is applied, how it may be limited, and how such limitations can be understood or even controlled in the natural sciences, computational sciences, life sciences, social sciences, and studies of science and technology. The book presents many chapters devoted to a variety of methods and techniques, as well as their epistemic and ontological underpinnings, which have been developed to safeguard reproducible research and curtail deficits and failures. The book also investigates the political, historical, and social practices that underlie repro...

  8. Statistical modelling of the differences between successive R-R intervals.

    Science.gov (United States)

    Mandrekar, Sumithra J; Nagaraja, Haikady N; Berntson, Gary G

    2005-02-15

    Understanding the behaviour of R-R interval data and its successive differences is critical to the dynamics of cardiac control. Several time domain measures that quantify R-R interval variability have important clinical significance in terms of risk stratification and evaluating the effectiveness of treatment procedures. The present approach at examining the distributions of successive beat-to-beat differences of R-R interval data from different populations and under different conditions (baseline and reaction times) provides a valuable insight into their previously unexplored distributional properties. In particular, our analysis reveals that the successive differences have non-normal statistical distributions (a contradiction to the commonly used assumption of normality), and the absolute successive R-R interval differences approximately follows a Weibull distribution. As an illustration of the utility of this approach, we explore the statistical properties of the time domain measure: root mean square successive difference, study the association between the Weibull scale parameter estimate and respiratory sinus arrhythmia, and propose improvements in artifact detection algorithms. Copyright 2004 John Wiley & Sons, Ltd.

  9. A conceptual model of individual competency components as one of the predictors of success in mergers and acquisitions

    Directory of Open Access Journals (Sweden)

    Darko Kovač

    2008-12-01

    Full Text Available The increasing challenge of how to balance “soft” human factors with “hard” financial factors in mergers and acquisitions (M&A to be successful is not new. However, the real challenge lies in the question of how, and with which yardstick, to measure and compare the human factor in both the acquiring and the acquired companies in all phases of M&A. In this study, a model for measuring and comparing the human factor with competencies is presented. The model enables the measuring of soft factors with quantitative criteria. A tripartite individual competency components construct is conceived: cognitive, affective and conative, to which the personal value system is added. The model discussed is based on empirical findings and the cases of two companies and literature. The model enables companies to compare differences in competencies and thus to plan activities how to overcome those differences and achieve a higher success rate in M&A.

  10. Opportunity for collaboration: a conceptual model of success in tobacco control and cancer prevention.

    Science.gov (United States)

    Stillman, Frances A; Schmitt, Carol L; Rosas, Scott R

    2012-01-01

    Collaborations between cancer prevention and tobacco control programs can leverage scarce resources to address noncommunicable diseases globally, but barriers to cooperation and actual collaboration are substantial. To foster collaboration between cancer prevention and tobacco control programs, the Global Health Partnership conducted research to identify similarities and differences in how the 2 programs viewed program success. Using concept mapping, cancer prevention and tobacco control experts generated statements describing the components of a successful cancer prevention or tobacco control program and 33 participants sorted and rated the final 99 statements. Multidimensional scaling analysis with a 2-dimensional solution was used to identify an 8-cluster conceptual map of program success. We calculated Pearson correlation coefficients for all 99 statements to compare the item-level ratings of both groups and used t tests to compare the mean importance of ratings assigned to each cluster. Eight major clusters of success were identified: 1) advocacy and persuasion, 2) building sustainability, 3) partnerships, 4) readiness and support, 5) program management fundamentals, 6) monitoring and evaluation, 7) utilization of evidence, and 8) implementation. We found no significant difference between the maps created by the 2 groups and only 1 mean difference for the importance ratings for 1 of the clusters: cancer prevention experts rated partnerships as more important to program success than did tobacco control experts. Our findings are consistent with those of research documenting the necessary components of successful programs and the similarities between cancer prevention and tobacco control. Both programs value the same strategies to address a common risk factor: tobacco use. Identifying common ground between these 2 research and practice communities can benefit future collaborations at the local, state, tribal, national, and international levels, and inform the

  11. Conceptual models of coronary perfusion pressure and their relationship to defibrillation success in a porcine model of prolonged out-of-hospital cardiac arrest

    Science.gov (United States)

    Reynolds, Joshua C.; Salcido, David D.; Menegazzi, James J.

    2012-01-01

    Introduction The amount of myocardial perfusion required for successful defibrillation after cardiac arrest is unknown. Coronary perfusion pressure (CPP) is a surrogate for myocardial perfusion. One limited clinical study identifies a threshold of 15 mmHg required for return of spontaneous circulation (ROSC). Our exploration of threshold and dose models of CPP during the initial bout of CPR indicates higher levels than previously demonstrated are required. CPP required for shock success throughout on-going resuscitation is unknown and other conceptual models of CPP have not been explored. Hypothesis An array of conceptual models of CPP is associated with and predicts defibrillation success throughout resuscitation. Methods Data from 6 porcine cardiac arrest studies were pooled. Mean and area under the curve (AUC) CPP were derived for 30-second epochs. Five conceptual models of CPP were analyzed: threshold, delta, cumulative delta, dose, and cumulative dose. Comparative statistics were performed with one-way ANOVA and two-tailed t-test. Regression models assessed CPP trends and prediction of ROSC. Results For 316 defibrillation attempts in 124 animals, those resulting in ROSC (n=75) had significantly higher threshold, delta, cumulative delta, dose, and cumulative dose CPP than those without. All conceptual models except delta CPP had significantly different values across successive defibrillation attempts and all five models were significant predictors of ROSC, along with experimental design. Conclusions Threshold, delta, cumulative delta, dose, and cumulative dose CPP predict individual defibrillation success throughout resuscitation. PMID:22266069

  12. A Model Midshipman: Factors Related to Academic and Military Success of Prior Enlisted Midshipmen at the United States Naval Academy

    National Research Council Canada - National Science Library

    Wyrick, Jared

    2005-01-01

    ... to be successful at the Naval Academy. Linear and Bi-Linear regression models are used to analyze the influence of prior-enlisted experience on academic and military performance at the Naval Academy on the classes from 1999 through 2004...

  13. A Path Analysis Model Pertinent to Undergraduates' Academic Success: Examining Academic Confidence, Psychological Capital and Academic Coping Factors

    Science.gov (United States)

    Kirikkanat, Berke; Soyer, Makbule Kali

    2018-01-01

    The major purpose of this study was to create a path analysis model of academic success in a group of university students, which included the variables of academic confidence and psychological capital with a mediator variable--academic coping. 400 undergraduates from Marmara University and Istanbul Commerce University who were in sophomore, junior…

  14. Comparison of the sensitivity of landscape-fire-succession models to variation in terrain, fuel pattern, climate and weather.

    Science.gov (United States)

    Geoffrey J. Cary; Robert E. Keane; Robert H. Gardner; Sandra Lavorel; Mike D. Flannigan; Ian D. Davies; Chao Li; James M. Lenihan; T. Scott Rupp; Florent. Mouillot

    2006-01-01

    The purpose of this study was to compare the sensitivity of nlodelled area burned to environmental factors across a range of independently-developed landscape-fire-succession models. The sensitivity of area burned to variation in four factors, namely terrain (flat, undulating and mountainous), fuel pattern (finely and coarsely clumped), climate (observed, warmer &...

  15. The Effects of Educative Software, Based on the Arcs Motivation Model on Student's Academic Success and Permanence in Education

    OpenAIRE

    Ümmü ÇETİN; Ahmet MAHİROĞLU

    2008-01-01

    In this study, education based on ARCS Motivation Model design principles and traditional education were compared in terms of student success and the continuance of learning. To this end, an educative software suitable to the design principles of ARCS Motivation Model for Microsoft Excels' "statistical functions" theme was prepared.With a pretest of the experimental and control group, the equivalence of the groups were determined. In the control group the laboratory study was performed with t...

  16. The Context-Dependency of the Experience of Auditory Succession and Prospects for Embodying Philosophical Models of Temporal Experience

    OpenAIRE

    Maria Kon

    2015-01-01

    Recent philosophical work on temporal experience offers generic models that are often assumed to apply to all sensory modalities. I show that the models serve as broad frameworks in which different aspects of cognitive science can be slotted and, thus, are beneficial to furthering research programs in embodied music cognition. Here I discuss a particular feature of temporal experience that plays a key role in such philosophical work: a distinction between the experience of succession and the ...

  17. Prediction Modeling for Academic Success in Professional Master's Athletic Training Programs

    Science.gov (United States)

    Bruce, Scott L.; Crawford, Elizabeth; Wilkerson, Gary B.; Rausch, David; Dale, R. Barry; Harris, Martina

    2016-01-01

    Context: A common goal of professional education programs is to recruit the students best suited for the professional career. Selection of students can be a difficult process, especially if the number of qualified candidates exceeds the number of available positions. The ability to predict academic success in any profession has been a challenging…

  18. Creating a Successful Citizen Science Model to Detect and Report Invasive Species

    Science.gov (United States)

    Gallo, Travis; Waitt, Damon

    2011-01-01

    The Invaders of Texas program is a successful citizen science program in which volunteers survey and monitor invasive plants throughout Texas. Invasive plants are being introduced at alarming rates, and our limited knowledge about their distribution is a major cause for concern. The Invaders of Texas program trains citizen scientists to detect the…

  19. Towards an Open Government Data Success Model : A case study from Indonesia

    NARCIS (Netherlands)

    Purwanto, A.; Janssen, M.F.W.H.A.; Zuiderwijk-van Eijk, AMG; Borge, Vieira; Rouco, José

    2017-01-01

    Governments around the world are following the global open government movement by initiating Open Government Data (OGD) programs. They are motivated by the claim that it will generate economic and social value. However, the success of an OGD initiative will only be realized when OGD is used and when

  20. A System's View of E-Learning Success Model

    Science.gov (United States)

    Eom, Sean B.; Ashill, Nicholas J.

    2018-01-01

    The past several decades of e-learning empirical research have advanced our understanding of the effective management of critical success factors (CSFs) of e-learning. Meanwhile, the proliferation of measures of dependent and independent variables has been overelaborated. We argue that a significant reduction in dependent and independent variables…

  1. Modelling cheetah relocation success in southern Africa using an iterative Bayesian network development cycle

    CSIR Research Space (South Africa)

    Johnson, S

    2010-02-01

    Full Text Available Relocation is one of the strategies used by conservationists to deal with problem cheetahs in southern Africa. The success of a relocation event and the factors that influence it within the broader context of long-term viability of wild cheetah...

  2. Sharing Responsibility for College Success: A Model Partnership Moves Students to Diplomas and Degrees

    Science.gov (United States)

    Vargas, Joel

    2014-01-01

    In order to prepare the large number of postsecondary-educated youth our economy demands, high schools and higher education must break through the boundaries that have traditionally separated them and assume joint responsibility for student success. This brief describes an unusual school district partnership with colleges that has achieved…

  3. The Economics of Reproducibility in Preclinical Research.

    Directory of Open Access Journals (Sweden)

    Leonard P Freedman

    2015-06-01

    Full Text Available Low reproducibility rates within life science research undermine cumulative knowledge production and contribute to both delays and costs of therapeutic drug development. An analysis of past studies indicates that the cumulative (total prevalence of irreproducible preclinical research exceeds 50%, resulting in approximately US$28,000,000,000 (US$28B/year spent on preclinical research that is not reproducible-in the United States alone. We outline a framework for solutions and a plan for long-term improvements in reproducibility rates that will help to accelerate the discovery of life-saving therapies and cures.

  4. Learning Reproducibility with a Yearly Networking Contest

    KAUST Repository

    Canini, Marco

    2017-08-10

    Better reproducibility of networking research results is currently a major goal that the academic community is striving towards. This position paper makes the case that improving the extent and pervasiveness of reproducible research can be greatly fostered by organizing a yearly international contest. We argue that holding a contest undertaken by a plurality of students will have benefits that are two-fold. First, it will promote hands-on learning of skills that are helpful in producing artifacts at the replicable-research level. Second, it will advance the best practices regarding environments, testbeds, and tools that will aid the tasks of reproducibility evaluation committees by and large.

  5. Thou Shalt Be Reproducible! A Technology Perspective

    Directory of Open Access Journals (Sweden)

    Patrick Mair

    2016-07-01

    Full Text Available This article elaborates on reproducibility in psychology from a technological viewpoint. Modernopen source computational environments are shown and explained that foster reproducibilitythroughout the whole research life cycle, and to which emerging psychology researchers shouldbe sensitized, are shown and explained. First, data archiving platforms that make datasets publiclyavailable are presented. Second, R is advocated as the data-analytic lingua franca in psychologyfor achieving reproducible statistical analysis. Third, dynamic report generation environments forwriting reproducible manuscripts that integrate text, data analysis, and statistical outputs such asfigures and tables in a single document are described. Supplementary materials are provided inorder to get the reader started with these technologies.

  6. Application of Goal Tree-Success Tree model as the knowledge-base of operator advisory systems

    International Nuclear Information System (INIS)

    Kim, I.S.; Modarres, M.

    1987-01-01

    The most important portion of an expert system development is the articulation of knowledge by the expert and its satisfactory formulation in a suitable knowledge representation scheme for mechanization by a computer. A 'deep knowledge' approach called Goal Tree-Success Tree model is devised to represent complex dynamic domain knowledge. This approach can hierarchically model the underlying principles of a given process domain (for example nuclear power plant operations domain). The Goal Tree-Success Tree can then be used to represent the knowledge-base and provide means of selecting an efficient search routine in the inference engine of an expert system. A prototype expert system has been developed to demonstrate the method. This expert system models the operation of a typical system used in the pressurized water reactors. The expert system is modeled for real-time operations if an interface between plant parameters and the expert system is established. The real-time operation provides an ability to quickly remedy minor disturbances that can quickly lead to a system malfunction or trip. A description of both the Goal Tree-Success Tree model and the prototype expert system is presented. (orig.)

  7. Paleogeographic and Depositional Model for the Neogene fluvial succession, Pishin Belt Northwest Pakistan

    DEFF Research Database (Denmark)

    Kasi, Aimal Khan; Kassi, Akhtar Muhammad; Umar, Muhammad

    2017-01-01

    Miocene subaerial sedimentation started after the final closure of Katawaz Remnant Ocean. Based on detailed field data twelve facies were recognized in Neogene successions exposed in Pishin Belt. These facies were further organized into four facies associations i.e. channels, crevasse splay, natural levee...... and floodplain facies associations. Facies associations and variations provided ample evidences to recognize number of fluvial architectural components in the succession e.g., low-sinuosity sandy braided river, mixed-load meandering, high-sinuosity meandering channels, single-story sandstone and/or conglomerate...... channels, lateral accretion surfaces (point bars) and alluvial fans. Neogene sedimentation in the Pishin Belt was mainly controlled by active tectonism and thrusting in response to oblique collision of the Indian Plate with Afghan Block of the Eurasian Plate along the Chaman-Nushki Fault. Post Miocene...

  8. The highly successful safe remediation of the Fernald waste pits undertaken under the privatization model

    Energy Technology Data Exchange (ETDEWEB)

    Cherry, Mark; Lojek, Dave; Murphy, Con

    2003-02-23

    Remediation of eight waste pits at the Department of Energy (DOE) Fernald site, located northwest of Cincinnati, Ohio, involves excavating approximately one million tonnes in-situ of low-level waste which were placed in pits during Fernald's production era. This unique project, one of the largest in the history of CERCLA/Superfund, includes uranium and thorium contaminated waste, soils and sludges. These wet soils and sludges are thermally dried in a processing facility to meet Department of Transportation (DOT) transportation and disposal facility waste acceptance criteria, loaded into railcars and shipped to the Envirocare waste disposal facility at Clive, Utah. This project is now approximately 60% complete with more than 415,000 tonnes (460,000 tons) of waste material safely shipped in 74 unit trains to Envirocare. Work is scheduled to be completed in early 2005. Success to date demonstrates that a major DOE site remediation project can be safely and successfully executed in partnership with private industry, utilizing proven commercial best practices, existing site labor resources and support of local stakeholders. In 1997 under the DOE's privatization initiative, Fluor Fernald, Inc. (Fluor Fernald) solicited the services of the remediation industry to design, engineer, procure, construct, own and operate a facility that would undertake the remediation of the waste pits. The resulting procurement was awarded to IT Corporation, currently Shaw Environmental and Infrastructure, Inc. (Shaw). The contractor was required to finance the procurement and construction of its facilities and infrastructure. The contract was performance-based and payment would be made on the successful loadout of the waste from the facility on a per-ton basis meeting the Envirocare waste acceptance criteria. This paper details the performance to date, the challenges encountered, and the seamless partnering between DOE, the Environmental Protection Agency (EPA), Fluor Fernald

  9. MS PHD'S: A successful model for reaching underrepresented minorities (URM) students through virtual platforms

    Science.gov (United States)

    Scott, O.; Johnson, A.; Williamson, V.; Ricciardi, L.; Jearld, A., Jr.; Guzman, W. I.

    2014-12-01

    To successfully recruit and retain underrepresented minority (URM) students and early career scientists, many programs supplement traditional curricular activities with multiple online platforms, establishing "virtual communities" that are free and easily accessible. These virtual communities offer readily sustainable opportunities to facilitate communication across a wide range of cultural lines and socioeconomic levels thereby broadening participation and inclusivity in STEM. Established in 2003, the Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S) in Earth System Science Professional Development Program has successfully used virtual community tools such as a listserv, community forum, social media, and VoIP technologies, to extend the face-to-face activities of the program and support the advancement of URM students and early career scientists in STEM. The use of multiple facets of virtual community by MS PHD'S participants supports and encourages "real life" interactions and mentorship, facilitates networking and professional development, and maintains continuity of shared networks. The program is now in its ninth cohort and supports 213 participants. To date, 54 participants have completed their PhD and another 61 are currently enrolled in doctoral programs.

  10. Transparent, reproducible and reusable research in pharmacoepidemiology

    NARCIS (Netherlands)

    Gardarsdottir, Helga; Sauer, Brian C.; Liang, Huifang; Ryan, Patrick; Klungel, Olaf; Reynolds, Robert

    2012-01-01

    Background: Epidemiological research has been criticized as being unreliable. Scientific evidence is strengthened when the study procedures of important findings are transparent, open for review, and easily reproduced by different investigators and in various settings. Studies often have common

  11. Thou Shalt Be Reproducible! A Technology Perspective

    Science.gov (United States)

    Mair, Patrick

    2016-01-01

    This article elaborates on reproducibility in psychology from a technological viewpoint. Modern open source computational environments are shown and explained that foster reproducibility throughout the whole research life cycle, and to which emerging psychology researchers should be sensitized, are shown and explained. First, data archiving platforms that make datasets publicly available are presented. Second, R is advocated as the data-analytic lingua franca in psychology for achieving reproducible statistical analysis. Third, dynamic report generation environments for writing reproducible manuscripts that integrate text, data analysis, and statistical outputs such as figures and tables in a single document are described. Supplementary materials are provided in order to get the reader started with these technologies. PMID:27471486

  12. Archiving Reproducible Research with R and Dataverse

    DEFF Research Database (Denmark)

    Leeper, Thomas

    2014-01-01

    Reproducible research and data archiving are increasingly important issues in research involving statistical analyses of quantitative data. This article introduces the dvn package, which allows R users to publicly archive datasets, analysis files, codebooks, and associated metadata in Dataverse...

  13. Impulsivity, perceived self-regulatory success in dieting, and body mass in children and adolescents: A moderated mediation model.

    Science.gov (United States)

    Meule, Adrian; Hofmann, Johannes; Weghuber, Daniel; Blechert, Jens

    2016-12-01

    Impulsivity has been suggested to contribute to overeating and obesity. However, findings are inconsistent and it appears that only specific facets of impulsivity are related to eating-related variables and to body mass. In the current study, relationships between self-reported impulsivity, perceived self-regulatory success in dieting, and objectively measured body mass were examined in N = 122 children and adolescents. Scores on attentional and motor impulsivity interactively predicted perceived self-regulatory success in dieting, but not body mass: Higher attentional impulsivity was associated with lower perceived self-regulatory success at high levels of motor impulsivity, but not at low levels of motor impulsivity. A moderated mediation model revealed an indirect effect of attentional and motor impulsivity on body mass, which was mediated by perceived self-regulatory success in dieting. Thus, results show that only specific facets of impulsivity are relevant in eating- and weight-regulation and interact with each other in the prediction of these variables. These facets of impulsivity, however, are not directly related to higher body mass, but indirectly via lower success in eating-related self-regulation in children and adolescents. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Comparative analysis of insect succession data from Victoria (Australia) using summary statistics versus preceding mean ambient temperature models.

    Science.gov (United States)

    Archer, Mel

    2014-03-01

    Minimum postmortem interval (mPMI) can be estimated with preceding mean ambient temperature models that predict carrion taxon pre-appearance interval. But accuracy has not been compared with using summary statistics (mean ± SD of taxon arrival/departure day, range, 95% CI). This study collected succession data from ten experimental and five control (infrequently sampled) pig carcasses over two summers (n = 2 experimental, n = 1 control per placement date). Linear and exponential preceding mean ambient temperature models for appearance and departure times were constructed for 17 taxa/developmental stages. There was minimal difference in linear or exponential model success, although arrival models were more often significant: 65% of linear arrival (r2 = 0.09–0.79) and exponential arrival models (r2 = 0.05–81.0) were significant, and 35% of linear departure (r2 = 0.0–0.71) and exponential departure models (r2 = 0.0–0.72) were significant. Performance of models and summary statistics for estimating mPMI was compared in two forensic cases. Only summary statistics produced accurate mPMI estimates.

  15. The Context-Dependency of the Experience of Auditory Succession and Prospects for Embodying Philosophical Models of Temporal Experience

    Directory of Open Access Journals (Sweden)

    Maria Kon

    2015-05-01

    Full Text Available Recent philosophical work on temporal experience offers generic models that are often assumed to apply to all sensory modalities. I show that the models serve as broad frameworks in which different aspects of cognitive science can be slotted and, thus, are beneficial to furthering research programs in embodied music cognition. Here I discuss a particular feature of temporal experience that plays a key role in such philosophical work: a distinction between the experience of succession and the mere succession of experiences. I question the presupposition that there is such an evident, clear distinction and suggest that, instead, how the distinction is drawn is context-dependent. After suggesting a way to modify the philosophical models of temporal experience to accommodate this context-dependency, I illustrate that these models can fruitfully incorporate features of research projects in embodied musical cognition. To do so I supplement a modified retentionalist model with aspects of recent work that links bodily movement with musical perception (Godøy, 2006; 2010a; Jensenius, Wanderley, Godøy, and Leman, 2010. The resulting model is shown to facilitate novel hypotheses, refine the notion of context-dependency and point towards means of extending the philosophical model and an existent research program.

  16. Developing a Mathematical Model for Scheduling and Determining Success Probability of Research Projects Considering Complex-Fuzzy Networks

    Directory of Open Access Journals (Sweden)

    Gholamreza Norouzi

    2015-01-01

    Full Text Available In project management context, time management is one of the most important factors affecting project success. This paper proposes a new method to solve research project scheduling problems (RPSP containing Fuzzy Graphical Evaluation and Review Technique (FGERT networks. Through the deliverables of this method, a proper estimation of project completion time (PCT and success probability can be achieved. So algorithms were developed to cover all features of the problem based on three main parameters “duration, occurrence probability, and success probability.” These developed algorithms were known as PR-FGERT (Parallel and Reversible-Fuzzy GERT networks. The main provided framework includes simplifying the network of project and taking regular steps to determine PCT and success probability. Simplifications include (1 equivalent making of parallel and series branches in fuzzy network considering the concepts of probabilistic nodes, (2 equivalent making of delay or reversible-to-itself branches and impact of changing the parameters of time and probability based on removing related branches, (3 equivalent making of simple and complex loops, and (4 an algorithm that was provided to resolve no-loop fuzzy network, after equivalent making. Finally, the performance of models was compared with existing methods. The results showed proper and real performance of models in comparison with existing methods.

  17. The Qinshan phase III project-a successful model of sino-canadian cooperation

    International Nuclear Information System (INIS)

    Pang, S.H.H.; Alikhan, S.; Gu Jun

    2005-01-01

    The Qinshan Phase III (CANDU) Project, the largest-scale cooperative project between China and Canada, was completed in 2003 well in advance of the schedule and 10% under budget. The Third Qinshan (Phase III) Nuclear Power Plant (TQNPP) was built in record times: Unit 1 achieved commercial operation on December 31, 2002 and Unit 2 on July 20, 2003, 43 days and 115 days ahead of schedule respectively. Improvements in design and construction methods allowed Unit 1 to be constructed in 51.5 months from First Concrete to Criticality - a record in China for nuclear power plants. The key factors are project management and project management tools, quality assurance, construction methods, electronic documentation with configuration control that provides up-to-date on-line information, CADDS design linked with material management and control. New design and construction techniques were introduced by combining conventional AECL practices with working experiences in China. The most advanced tools and techniques for achieving optimum construction quality, schedule and cost were used. Successful application of advanced project management methods and tools has benefited TQNPC in its subsequent plant operation, and the Chinese contractors in advancing their capabilities in future nuclear projects in China as well as enhancing their opportunities internationally. Excellent co-operation and teamwork within the integrated TQNPC/AECL Commissioning Team with well documented QA program, process and procedures also contributed to the remarkable success of the Project. AECL's initial assessment, based on lessons learned, showed that the project schedule could readily be reduced to 66 months and the capital costs reduced by 25% for a replication project. AECL is building on this experience and successful results of TQNPP in its Advanced CANDU Reactor TM (ACR TM ) ** design. (authors)

  18. Pedagogical models for video communication in massive open on-line courses (MOOCs: a success story

    Directory of Open Access Journals (Sweden)

    María Amata Garito

    2015-05-01

    Full Text Available The initiatives on MOOCs promoted in the United States by prestigious universities, such as Stanford, Harvard, MIT, and by private bodies such as Udacity, aroused great interest worldwide; however the teaching and learning models proposed with MOOCs do not appear to rely on solid theoretical bases and, therefore, on valuable psycho-pedagogical models. The aim of this paper is to analyze some pedagogical aspects related to video communication models in order to highlight the strong and weak points of the educational framework of these initiatives. The teaching models adopted by the International Telematic University UNINETTUNO for its video lessons, the distance assessment systems, the teacher/tutor and student distance interaction models reached such a quality level that it allows us to generalize this model and trigger teaching and learning processes of high quality and to lower the dropouts rates of the students enrolled in MOOCs.

  19. Evaluation of a comprehensive EHR based on the DeLone and McLean model for IS success: approach, results, and success factors.

    Science.gov (United States)

    Bossen, Claus; Jensen, Lotte Groth; Udsen, Flemming Witt

    2013-10-01

    difficult, but was required because a key role was to inform decision-making upon enrollment at other hospitals and systematically identify barriers in this respect. The strength of the evaluation is the mixed-methods approach. Further, the evaluation was based on assessments from staff in two departments that comprise around 50% of hospital staff. A weakness may be that staff assessment plays a major role in interviews and survey. These though are supplemented by performance data and observation. Also, the evaluation primarily reports upon the dimension 'user satisfaction', since use of the EHR is mandatory. Finally, generalizability may be low, since the evaluation was not based on a validated survey. All in all, however, the evaluation proposes an evaluation design in constrained circumstances. Despite inherent limitations, evaluation of a comprehensive EHR shortly after implementation may be necessary, can be conducted, and may inform political decision making. The updated DeLone and McLean framework was constructive in the overall design of the evaluation of the EHR implementation, and allowed the model to be adapted to the health care domain by being methodological flexible. The mixed-methods case study produced valid and reliable results, and was accepted by staff, system providers, and political decision makers. The successful implementation may be attributed to the configurability of the EHR and to factors such as an experienced, competent implementation organization at the hospital, upgraded soft- and hardware, and a high degree of user involvement. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  20. An investigation of potential success factors for an introductory model-driven programming course

    DEFF Research Database (Denmark)

    Bennedsen, Jens; Caspersen, Michael Edelgaard

    2005-01-01

    interval: math grade from high school and course work. The two significant indicators explain 24.2% of the variation of the exam grade. The result concerning math grade contradicts earlier findings. We discuss four aspects of our research: the explanation power of the potential success indicators......, the impact of our findings on teaching, limits of what to conclude from the available data, and the variety of the notion "objects-first". Because of the variety of interpretations of "objects-first", the present research is necessary as a supplement to earlier research in order to make generalizable results...

  1. Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method.

    Science.gov (United States)

    Plum, Jakob; Madsen, Cecilie M; Teleki, Alexandra; Bevernage, Jan; da Costa Mathews, Claudia; Karlsson, Eva M; Carlert, Sara; Holm, Rene; Müller, Thomas; Matthews, Wayne; Sayers, Alice; Ojala, Krista; Tsinsman, Konstantin; Lingamaneni, Ram; Bergström, Christel As; Rades, Thomas; Müllertz, Anette

    2017-12-04

    The high number of poorly water-soluble compounds in drug development has increased the need for enabling formulations to improve oral bioavailability. One frequently applied approach is to induce supersaturation at the absorptive site, e.g., the small intestine, increasing the amount of dissolved compound available for absorption. However, due to the stochastic nature of nucleation, supersaturating drug delivery systems may lead to inter- and intrapersonal variability. The ability to define a feasible range with respect to the supersaturation level is a crucial factor for a successful formulation. Therefore, an in vitro method is needed, from where the ability of a compound to supersaturate can be defined in a reproducible way. Hence, this study investigates the reproducibility of an in vitro small scale standardized supersaturation and precipitation method (SSPM). First an intralaboratory reproducibility study of felodipine was conducted, after which seven partners contributed with data for three model compounds; aprepitant, felodipine, and fenofibrate, to determine the interlaboratory reproducibility of the SSPM. The first part of the SSPM determines the apparent degrees of supersaturation (aDS) to investigate for each compound. Each partner independently determined the maximum possible aDS and induced 100, 87.5, 75, and 50% of their determined maximum possible aDS in the SSPM. The concentration-time profile of the supersaturation and following precipitation was obtained in order to determine the induction time (t ind ) for detectable precipitation. The data showed that the absolute values of t ind and aDS were not directly comparable between partners, however, upon linearization of the data a reproducible rank ordering of the three model compounds was obtained based on the β-value, which was defined as the slope of the ln(t ind ) versus ln(aDS) -2 plot. Linear regression of this plot showed that aprepitant had the highest β-value, 15.1, while felodipine and

  2. Data Science Innovations That Streamline Development, Documentation, Reproducibility, and Dissemination of Models in Computational Thermodynamics: An Application of Image Processing Techniques for Rapid Computation, Parameterization and Modeling of Phase Diagrams

    Science.gov (United States)

    Ghiorso, M. S.

    2014-12-01

    Computational thermodynamics (CT) represents a collection of numerical techniques that are used to calculate quantitative results from thermodynamic theory. In the Earth sciences, CT is most often applied to estimate the equilibrium properties of solutions, to calculate phase equilibria from models of the thermodynamic properties of materials, and to approximate irreversible reaction pathways by modeling these as a series of local equilibrium steps. The thermodynamic models that underlie CT calculations relate the energy of a phase to temperature, pressure and composition. These relationships are not intuitive and they are seldom well constrained by experimental data; often, intuition must be applied to generate a robust model that satisfies the expectations of use. As a consequence of this situation, the models and databases the support CT applications in geochemistry and petrology are tedious to maintain as new data and observations arise. What is required to make the process more streamlined and responsive is a computational framework that permits the rapid generation of observable outcomes from the underlying data/model collections, and importantly, the ability to update and re-parameterize the constitutive models through direct manipulation of those outcomes. CT procedures that take models/data to the experiential reference frame of phase equilibria involve function minimization, gradient evaluation, the calculation of implicit lines, curves and surfaces, contour extraction, and other related geometrical measures. All these procedures are the mainstay of image processing analysis. Since the commercial escalation of video game technology, open source image processing libraries have emerged (e.g., VTK) that permit real time manipulation and analysis of images. These tools find immediate application to CT calculations of phase equilibria by permitting rapid calculation and real time feedback between model outcome and the underlying model parameters.

  3. INFORMATION SYSTEM QUALITY INFLUENCE ON ORGANIZATION PERFORMANCE: A MODIFICATION OF TECHNOLOGY-BASED INFORMATION SYSTEM ACCEPTANCE AND SUCCESS MODEL

    Directory of Open Access Journals (Sweden)

    Trisnawati N.

    2017-12-01

    Full Text Available This study aims to examine the effect of information system quality on technology-based accounting information systems usage and their impact on organizational performance on local government. This study is based on Technology Acceptance Model (TAM, IS Success Model, and the success of technology-based information systems. This study is a combination of previous studies conducted by Seddon and Kiew (1997, Saeed and Helm (2008, and DeLone and McLean (1992. This study used survey method and took 101 respondents from accounting staff working in Malang and Mojokerto regencies. This study uses Partial Least Square to examine research data. Research result exhibits information system qualities affecting benefit perception and user satisfaction. Technology-based accounting information systems usage in local government is influenced by benefits perception and user satisfaction. Research result concluded that technology-based accounting information systems usage will affect the performance of local government organizations.

  4. Exploring the role of fire, succession, climate, and weather on landscape dynamics using comparative modeling

    Science.gov (United States)

    Robert E. Keane; Geoffrey J. Cary; Mike D. Flannigan; Russell A. Parsons; Ian D. Davies; Karen J. King; Chao Li; Ross A. Bradstock; Malcolm Gill

    2013-01-01

    An assessment of the relative importance of vegetation change and disturbance as agents of landscape change under current and future climates would (1) provide insight into the controls of landscape dynamics, (2) help inform the design and development of coarse scale spatially explicit ecosystem models such as Dynamic Global Vegetation Models (DGVMs), and (3) guide...

  5. A Comparative Study of Successful Central Nervous System Drugs Using Molecular Modeling

    Science.gov (United States)

    Kim, Hyosub; Sulaimon, Segun; Menezes, Sandra; Son, Anne; Menezes, Warren J. C.

    2011-01-01

    Molecular modeling is a powerful tool used for three-dimensional visualization and for exploring electrostatic forces involved in drug transport. This tool enhances student understanding of structure-property relationships, as well as actively engaging them in class. Molecular modeling of several central nervous system (CNS) drugs is used to…

  6. National Culture and Business Model Change - A Framework for Successful Expansions

    DEFF Research Database (Denmark)

    Stenskov, Lea Houmark; Lueg, Rainer

    2014-01-01

    , we integrate the concepts of business models (Osterwalder and Pigneur, 2005) and national culture (Hofstede, 1980). Our findings explain why and how adjustments in the business model are necessary regarding the company’s communication, team composition, and customer involvement in projects...

  7. Modelling biogeochemical-stratigraphic dynamics of clinoform successions over geological timescales

    DEFF Research Database (Denmark)

    Legarth, Jens Jakob Fosselius; Bjerrum, Christian J.

    are investigated with our novel dynamic biogeochemical-stratigraphic model which explicitly calculates sediment and biogeochemical tracer erosion and deposition over multi-kilo-years. In the model organic and uranium enrichment in the distal clinoform develops as a transgressive nature. As a result part...

  8. Sales Training for Army Recruiter Success: Modeling the Sales Strategies and Skills of Excellent Recruiters

    Science.gov (United States)

    1987-11-01

    strategies used by excellent Army recruiters. Neurolinguistic programming (NLP) was used as the protocol for modeling performance and acquiring...Behavioral and Social Sciences 3001 Eisenhower Avenue, Alexandria, VA 22333-5600 10. PROGRAM ELEMENT. PROJECT. TASK ARE* 4 WORK UNIT...Modeling ’Expert knowledge,, Neurolinguistics Knowledge engineering; Recruiting Sales, &’ Sales cycle Sales skills Sales strategies 20

  9. Relating Successful Business Models to Intellectual Capital and Knowledge Management Practices

    DEFF Research Database (Denmark)

    Nielsen, Christian

    2018-01-01

    There are a number of natural links between the fields of business models and knowledge management. The contemporary understanding of business models is that they are concerned with describing and analyzing the methods of value creation and the alternative ways of delivering use value to customers...... that are applied by organizations. Similarly, knowledge management also has intricate connections with mechanisms of value creation, through the structuring and improvement of knowledge processes in a given organization. Ensuring that the right knowledge is present is an important part of any business model...... innovation exercise. By applying the lens of intellectual capital, a natural link between business models and knowledge management is established. From this link, it is possible to structure and describe key characteristics. This paper accounts for the relationships between business models and knowledge...

  10. Modeling the relations between flow regime components, species traits, and spawning success of fishes in warmwater streams

    Science.gov (United States)

    Craven, S.W.; Peterson, J.T.; Freeman, Mary C.; Kwak, T.J.; Irwin, E.

    2010-01-01

    Modifications to stream hydrologic regimes can have a profound influence on the dynamics of their fish populations. Using hierarchical linear models, we examined the relations between flow regime and young-of-year fish density using fish sampling and discharge data from three different warmwater streams in Illinois, Alabama, and Georgia. We used an information theoretic approach to evaluate the relative support for models describing hypothesized influences of five flow regime components representing: short-term high and low flows; short-term flow stability; and long-term mean flows and flow stability on fish reproductive success during fish spawning and rearing periods. We also evaluated the influence of ten fish species traits on fish reproductive success. Species traits included spawning duration, reproductive strategy, egg incubation rate, swimming locomotion morphology, general habitat preference, and food habits. Model selection results indicated that young-of-year fish density was positively related to short-term high flows during the spawning period and negatively related to flow variability during the rearing period. However, the effect of the flow regime components varied substantially among species, but was related to species traits. The effect of short-term high flows on the reproductive success was lower for species that broadcast their eggs during spawning. Species with cruiser swimming locomotion morphologies (e.g., Micropterus) also were more vulnerable to variable flows during the rearing period. Our models provide insight into the conditions and timing of flows that influence the reproductive success of warmwater stream fishes and may guide decisions related to stream regulation and management. ?? 2010 US Government.

  11. Successful therapies for Alzheimer’s disease: Why so many in animal models and none in humans?

    Directory of Open Access Journals (Sweden)

    Rafael eFranco

    2014-06-01

    Full Text Available Peering into the field of Alzheimer's disease (AD the outsider realizes that many of the therapeutic strategies tested (in animal models have been successful. One also may notice that there is a deficit in translational research, i.e. to take a successful drug in mice and translate it to the patient. Efforts are still focused on novel projects to expand the therapeutic arsenal to cure mice. Scientific reasons behind so many successful strategies are not obvious. This article aims to review the current approaches to combat AD, and to open a debate on common mechanisms of cognitive enhancement and neuroprotection. In short, either the rodent models are not good and should be discontinued, or we should extract only the most useful information from those models. An example of a question that may be debated for the advancement in AD therapy is: In addition to reducing amyloid and tau pathologies, would it be necessary to boost synaptic strength and cognition? The debate would provide helpful information that could turn around the current negative output in generating effective drugs for patients. Furthermore, discovery of biomarkers in human body fluids, and a clear distinction between cognitive enhancers and disease modifying strategies, should be instrumental for advancing in anti-AD drug discovery.

  12. Canadian Model of Military Leadership as a Successful Mixture of Civilian and Military Experiences

    Directory of Open Access Journals (Sweden)

    Piotr Malinowski

    2015-06-01

    Full Text Available The origins of military leadership are rooted in ancient times and its embodiment are great chieftains and commanders. However, since the moment when in organisation and management sciences the civil theories of leadership started to emerge, the military forces have incorporated their solutions to structure the assumptions of new, coherent and effective models of military leadership. A good example of such solutions is the Canadian model of military leadership, competently merging the civil theories with experience and needs of the military environment. This solution may be a perfect example of effective application of leadership theory to modify the existing national model of military leadership and construct a more efficient one.

  13. Marital Success from the Perspective of Kozielecki’s Transgression Model

    Directory of Open Access Journals (Sweden)

    Dakowicz Andrzej

    2015-03-01

    Full Text Available Spouses exhibit two kinds of behaviours: protective and transgressive. Protective acts are those aiming to overcome current problems, leading to preserving some balance. Transgressive acts are deliberately overstepping everyday marital reality and doing new things in new ways. They lead to changing the relation with the hope of improving it, but also create the risk of deterioration. The more transgressive behaviours spouses exhibit, the more chances they have to get to know each other and experience the joy of being part of a union. Transgressive tendencies stem from a network personality structure and consist of five psychons: cognitive, instrumental, motivational, emotional, and personal. The success of a marriage is the effect of a specific form of transgressive behaviours in marriage exhibited by both spouses, which is recognizing difficulties as they appear, finding their sources, and taking steps together to overcome them.

  14. Effectively translating diabetes prevention: a successful model in a historically underserved community.

    Science.gov (United States)

    Horowitz, Carol R; Eckhardt, Sarah; Talavera, Sandra; Goytia, Crispin; Lorig, Kate

    2011-09-01

    Lifestyle interventions can prevent diabetes through weight loss, but they are rarely translated for use in underserved communities. The aim of this study was to describe how a community-academic partnership formed and developed a program to address local health disparities by developing a low-cost, culturally and economically appropriate, peer-led community-based diabetes prevention program. Using a participatory approach, the partnership chose to focus on diabetes prevention, and co-developed all intervention, recruitment, research, and evaluation strategies. The partnership's philosophy to maintain high clinical and scientific standards paired with their ability to represent and engage the community facilitated the development of a randomized controlled trial that achieved statistically significant and sustained weight loss, and the recruitment of a largely Spanish-speaking, low income, uninsured population. The success of this intervention lies in the partnership's commitment to the community, co-ownership of research, and a careful balance between academic rigor and community engagement and relevance.

  15. Potential Success and Barrier Factors for Implementation of the Transition to Independence (TIP Model

    Directory of Open Access Journals (Sweden)

    Christopher M. Kalinyak

    2017-01-01

    Full Text Available In this qualitative study, 28 key stakeholders who work with transition-aged youth participated in focus group discussions addressing success and barrier factors regarding implementation of a transition to independence process (TIP program for youth, ages 14–29, in three Midwestern cities. All participants had prior knowledge of TIP. The paradigm shift to client-oriented goals and services was acknowledged by respondents as the prime benefit of TIP; youth are more motivated to follow through on self-determined goals. Barrier factors for providers involved collaboration with agencies adhering to provider-oriented interventions, provision of TIP methods training, and reallocation of time and money. Barrier factors for youth involved mistrust of service providers, overcoming maturational deficits, and acquiring and maintaining relationships, reputations, and social supports.

  16. The Cognitive Reserve Model in the Development of Delirium: The Successful Aging After Elective Surgery Study.

    Science.gov (United States)

    Cizginer, Sevdenur; Marcantonio, Edward; Vasunilashorn, Sarinnapha; Pascual-Leone, Alvaro; Shafi, Mouhsin; Schmitt, Eva M; Inouye, Sharon K; Jones, Richard N

    2017-11-01

    We evaluated the role of cognitive and brain reserve markers in modifying the risk of postoperative delirium associated with a pathophysiologic marker. The Successful Aging after Elective Surgery study (SAGES) enrolled 556 adults age ≥70 years without dementia scheduled for major surgery. Patients were assessed preoperatively and daily during hospitalization for delirium. We used C-reactive protein (CRP) as a pathophysiologic marker of inflammation, previously associated with delirium. Markers of reserve included vocabulary knowledge, education, cognitive activities, occupation type and complexity, head circumference, intracranial volume, and leisure activities. Vocabulary knowledge, cognitive activities, and education significantly modified the association of CRP and postoperative delirium ( P delirium associated with lower grade inflammatory processes, supporting the role of reserve in delirium.

  17. Stimulating seedling growth in early stages of secondary forest succession: a modeling approach to guide tree liberation.

    Directory of Open Access Journals (Sweden)

    Marijke van Kuijk

    2014-07-01

    Full Text Available Excessive growth of non-woody plants and shrubs on degraded lands can strongly hamper tree growth and thus secondary forest succession. A common method to accelerate succession, called liberation, involves opening up the vegetation canopy around young target trees. This can increase growth of target trees by reducing competition for light with neighboring plants. However, liberation has not always the desired effect, likely due to differences in light requirement between tree species. Here we present a 3D-model, which calculates photosynthetic rate of individual trees in a vegetation stand. It enables us to examine how stature, crown structure and physiological traits of target trees and characteristics of the surrounding vegetation together determine effects of light on tree growth. The model was applied to a liberation experiment conducted with three pioneer species in a young secondary forest in Vietnam. Species responded differently to the treatment depending on their height, crown structure and their shade-tolerance level. Model simulations revealed practical thresholds over which the tree growth response is heavily influenced by the height and density of surrounding vegetation and gap radius. There were strong correlations between calculated photosynthetic rates and observed growth: the model was well able to predict growth of trees in young forests and the effects of liberation there upon. Thus our model serves as a useful tool to analyze light competition between young trees and surrounding vegetation and may help assess the potential effect of tree liberation.

  18. Stimulating seedling growth in early stages of secondary forest succession: a modeling approach to guide tree liberation.

    Science.gov (United States)

    van Kuijk, Marijke; Anten, Niels P R; Oomen, Roelof J; Schieving, Feike

    2014-01-01

    Excessive growth of non-woody plants and shrubs on degraded lands can strongly hamper tree growth and thus secondary forest succession. A common method to accelerate succession, called liberation, involves opening up the vegetation canopy around young target trees. This can increase growth of target trees by reducing competition for light with neighboring plants. However, liberation has not always had the desired effect, likely due to differences in light requirement between tree species. Here we present a 3D-model, which calculates photosynthetic rate of individual trees in a vegetation stand. It enables us to examine how stature, crown structure, and physiological traits of target trees and characteristics of the surrounding vegetation together determine effects of light on tree growth. The model was applied to a liberation experiment conducted with three pioneer species in a young secondary forest in Vietnam. Species responded differently to the treatment depending on their height, crown structure and their shade-tolerance level. Model simulations revealed practical thresholds over which the tree growth response is heavily influenced by the height and density of surrounding vegetation and gap radius. There were strong correlations between calculated photosynthetic rates and observed growth: the model was well able to predict growth of trees in young forests and the effects of liberation there upon. Thus, our model serves as a useful tool to analyze light competition between young trees and surrounding vegetation and may help assess the potential effect of tree liberation.

  19. A new model to simulate climate-change impacts on forest succession for local land management.

    Science.gov (United States)

    Yospin, Gabriel I; Bridgham, Scott D; Neilson, Ronald P; Bolte, John P; Bachelet, Dominique M; Gould, Peter J; Harrington, Constance A; Kertis, Jane A; Evers, Cody; Johnson, Bart R

    2015-01-01

    We developed a new climate-sensitive vegetation state-and-transition simulation model (CV-STSM) to simulate future vegetation at a fine spatial grain commensurate with the scales of human land-use decisions, and under the joint influences of changing climate, site productivity, and disturbance. CV-STSM integrates outputs from four different modeling systems. Successional changes in tree species composition and stand structure were represented as transition probabilities and organized into a state-and-transition simulation model. States were characterized based on assessments of both current vegetation and of projected future vegetation from a dynamic global vegetation model (DGVM). State definitions included sufficient detail to support the integration of CV-STSM with an agent-based model of land-use decisions and a mechanistic model of fire behavior and spread. Transition probabilities were parameterized using output from a stand biometric model run across a wide range of site productivities. Biogeographic and biogeochemical projections from the DGVM were used to adjust the transition probabilities to account for the impacts of climate change on site productivity and potential vegetation type. We conducted experimental simulations in the Willamette Valley, Oregon, USA. Our simulation landscape incorporated detailed new assessments of critically imperiled Oregon white oak (Quercus garryana) savanna and prairie habitats among the suite of existing and future vegetation types. The experimental design fully crossed four future climate scenarios with three disturbance scenarios. CV-STSM showed strong interactions between climate and disturbance scenarios. All disturbance scenarios increased the abundance of oak savanna habitat, but an interaction between the most intense disturbance and climate-change scenarios also increased the abundance of subtropical tree species. Even so, subtropical tree species were far less abundant at the end of simulations in CV-STSM than in

  20. Successful Internet Entrepreneurs Don't Have to Be College Dropouts: A Model for Nurturing College Students to Become Successful Internet Entrepreneurs

    Science.gov (United States)

    Zhang, Sonya

    2014-01-01

    Some of today's most successful Internet entrepreneurs didn't graduate from college. Many young people today followed the same path to pursue their dreams however ended up failing, not a surprise because 80% of the startups fail in first 5 years. As technology innovation and market competition on Internet continue to accelerate, college students…

  1. Software Reuse Success Strategy Model: An Empirical Study of Factors Involved in the Success of Software Reuse in Information System Development

    Science.gov (United States)

    Tran, Kiet T.

    2012-01-01

    This study examined the relationship between information technology (IT) governance and software reuse success. Software reuse has been mostly an IT problem but rarely a business one. Studies in software reuse are abundant; however, to date, none has a deep appreciation of IT governance. This study demonstrated that IT governance had a positive…

  2. Adaptation of a community-based participatory research model to gain community input on identifying indicators of successful parenting.

    Science.gov (United States)

    Zlotnick, Cheryl; Wright, Marguerite; Sanchez, Roberto Macias; Kusnir, Rosario Murga; Te'o-Bennett, Iemaima

    2010-01-01

    Parenting models are generally based on families in stable homes, rather than in transitional situations such as in foster care, homeless shelters, and other temporary, at-risk residences. Consequently, these models do not recognize the unique challenges of families in transition. This study explored the domains of the Circumplex Model and examined its fit for transitional families using tenets from community-based participatory research. Findings suggest that in addition to the Circumplex Model's components, caregivers with children living in transition believe that managing the scrutiny of external authority systems and countering the negative influences of poverty and racism are two indicators that contribute to parenting success. Obtaining consumer-informed views of parenting not only is an important contributor to standards of practice, but also a promising avenue for future research.

  3. Reproducibility of pacing profiles in elite swimmers.

    Science.gov (United States)

    Skorski, Sabrina; Faude, Oliver; Caviezel, Seraina; Meyer, Tim

    2014-03-01

    To analyze the reproducibility of pacing in elite swimmers during competitions and to compare heats and finals within 1 event. Finals and heats of 158 male swimmers (age 22.8 ± 2.9 y) from 29 nations were analyzed in 2 competitions (downloaded from swimrankings.net). Of these, 134 were listed in the world's top 50 in 2010; the remaining 24 were finalists of the Pan Pacific Games or European Championships. The level of both competitions for the analysis had to be at least national championships (7.7 ± 5.4 wk apart). Standard error of measurement expressed as percentage of the subject's mean score (CV) with 90% confidence limits (CL) for each 50-m split time and for total times were calculated. In addition, mixed general modeling was used to determine standard deviations between and within swimmers. CV for total time in finals ranged between 0.8% and 1.3% (CL 0.6-2.2%). Regarding split times, 200-m freestyle showed a consistent pacing over all split times (CV 0.9-1.6%). During butterfly, backstroke, and 400-m freestyle, CVs were low in the first 3 and 7 sections, respectively (CV 0.9-1.7%), with greater variability in the last section (1.9-2.2%). In breaststroke, values were higher in all sections (CV 1.2-2.3%). Within-subject SDs for changes between laps were between 0.9% and 2.6% in all finals. Split-time variability for finals and heats ranged between 0.9% and 2.5% (CL 0.3-4.9%). Pacing profiles are consistent between different competitions. Variability of pacing seems to be a result of the within-subject variation rather than a result of different competitions.

  4. Success of Arnol'd's method in hierarchy of ocean models

    International Nuclear Information System (INIS)

    Ripa, P.

    1993-01-01

    The method of Arnol'd is used to derive stability conditions of Hamiltonian systems with singular Poisson brackets; notably, those of fluid mechanics. Let the field(s) var-phi(x,t) represent the state variables, and Hamiltonian H [var-phi] and Poisson bracket (.,.) be such that ∂ t var-phi = (var-phi, H). The bracket must have the usual properties; in addition, it may be singular, i.e. there may exist non-trivial functional(s) of state C(var-phi) - called Casimir(s) - such that (C,F) ≡ 0, for any admissible functional of state F(var-phi). Arnol'd's theorms on stability are applied to put constraints on the solutions var-phi(x,t). This model is then applied to the problem of circulation within ocean models, in particular to two families of classical ocean models, primitive equations (PEN) and quasi-geostrophic (QGM) models. These models are layered vertical structures with top and bottom boundaries which may be either rigid or free

  5. Partnerships for success: A collaborative support model to enhance the first year student experience

    Directory of Open Access Journals (Sweden)

    Johanna Einfalt

    2013-04-01

    Full Text Available Recent discourse about engaging first year students calls for more collaboration in terms of adopting a holistic approach to course delivery and support. This paper discusses a collaborative support model operating at a regional Australian university since 2008. In particular, it describes a collaborative support initiative emerging from this model that is based on providing an informal consultative space where students can drop-in and gain assessment support for research, writing and content. A focus group, online surveys and interviews with co-ordinators were conducted to evaluate the impact of this initiative. Findings suggest that this collaborative support model impacts on the first year student experience by: raising awareness about academic skills and the processes for researching and writing; promoting peer learning opportunities; building confidence and providing suitable support for a diverse range of students.

  6. Enacting the International/Reproducing Eurocentrism

    Directory of Open Access Journals (Sweden)

    Zeynep Gülşah Çapan

    Full Text Available Abstract This article focuses on the way in which Eurocentric conceptualisations of the ‘international’ are reproduced in different geopolitical contexts. Even though the Eurocentrism of International Relations has received growing attention, it has predominantly been concerned with unearthing the Eurocentrism of the ‘centre’, overlooking its varied manifestations in other geopolitical contexts. The article seeks to contribute to discussions about Eurocentrism by examining how different conceptualisations of the international are at work at a particular moment, and how these conceptualisations continue to reproduce Eurocentrism. It will focus on the way in which Eurocentric designations of spatial and temporal hierarchies were reproduced in the context of Turkey through a reading of how the ‘Gezi Park protests’ of 2013 and ‘Turkey’ itself were written into the story of the international.

  7. Breeding success of a marine central place forager in the context of climate change: A modeling approach.

    Directory of Open Access Journals (Sweden)

    Lauriane Massardier-Galatà

    Full Text Available In response to climate warming, a southward shift in productive frontal systems serving as the main foraging sites for many top predator species is likely to occur in Subantarctic areas. Central place foragers, such as seabirds and pinnipeds, are thus likely to cope with an increase in the distance between foraging locations and their land-based breeding colonies. Understanding how central place foragers should modify their foraging behavior in response to changes in prey accessibility appears crucial. A spatially explicit individual-based simulation model (Marine Central Place Forager Simulator (MarCPFS, including bio-energetic components, was built to evaluate effects of possible changes in prey resources accessibility on individual performances and breeding success. The study was calibrated on a particular example: the Antarctic fur seal (Arctocephalus gazella, which alternates between oceanic areas in which females feed and the land-based colony in which they suckle their young over a 120 days rearing period. Our model shows the importance of the distance covered to feed and prey aggregation which appeared to be key factors to which animals are highly sensitive. Memorization and learning abilities also appear to be essential breeding success traits. Females were found to be most successful for intermediate levels of prey aggregation and short distance to the resource, resulting in optimal female body length. Increased distance to resources due to climate warming should hinder pups' growth and survival while female body length should increase.

  8. Collegiate Student-Athletes' Academic Success: Academic Communication Apprehension's Impact on Prediction Models

    Science.gov (United States)

    James, Kai'Iah A.

    2010-01-01

    This dissertation study examines the impact of traditional and non-cognitive variables on the academic prediction model for a sample of collegiate student-athletes. Three hundred and fifty-nine NCAA Division IA male and female student-athletes, representing 13 sports, including football and Men's and Women's Basketball provided demographic…

  9. Modeling and Simulation for Enterprise Decision-Making: Successful Projects and Approaches

    DEFF Research Database (Denmark)

    Ramadan, Noha; Ajami, Racha; Mohamed, Nader

    2015-01-01

    Decision-making in enterprises holds different possibilities for profits and risks. Due to the complexity of decision making processes, modeling and simulation tools are being used to facilitate them and minimize the risk of making wrong decisions in the various business process phases. In this p...

  10. Human Behavior Based Exploratory Model for Successful Implementation of Lean Enterprise in Industry

    Science.gov (United States)

    Sawhney, Rupy; Chason, Stewart

    2005-01-01

    Currently available Lean tools such as Lean Assessments, Value Stream Mapping, and Process Flow Charting focus on system requirements and overlook human behavior. A need is felt for a tool that allows one to baseline personnel, determine personnel requirements and align system requirements with personnel requirements. Our exploratory model--The…

  11. Vegetation succession as affected by decreasing nitrogen deposition, soil characteristics and site management: A modelling approach

    NARCIS (Netherlands)

    Wamelink, G.W.W.; Dobben, van H.F.; Berendse, F.

    2009-01-01

    After many years of increasing nitrogen deposition, the deposition rates are now decreasing. A major question is whether this will result in the expected positive effects on plant species diversity. Long-term experiments that investigate the effects of decreasing deposition are not available. Model

  12. "Someone like Me Can Be Successful": Do College Students Need Same-Gender Role Models

    Science.gov (United States)

    Lockwood, Penelope

    2006-01-01

    Two studies examined the extent to which matching on gender determines the impact of career role models on the self. Because women face negative stereotypes regarding their competence in the workplace, they may derive particular benefit from the example of an outstanding woman who illustrates the possibility of overcoming gender barriers to…

  13. Online revenue models in the media sector : an exploratory study on their success factors and adoption

    NARCIS (Netherlands)

    Stienstra, Martin R.; Ruel, Hubertus Johannes Maria; Boerrigter, Thomas

    2010-01-01

    Especially for companies in the media sector such as publishers, the Internet has created new strategic and commercial opportunities. However, many companies in the media sector are struggling with how to adapt their business and revenue model for doing profitable business online. This exploratory

  14. Modeling and Simulation for Enterprise Decision-Making: Successful Projects and Approaches

    DEFF Research Database (Denmark)

    Ramadan, Noha; Ajami, Racha; Mohamed, Nader

    Decision-making in enterprises holds different possibilities for profits and risks. Due to the complexity of decision making processes, modeling and simulation tools are being used to facilitate them and minimize the risk of making wrong decisions in the various business process phases. In this p...

  15. Pathways to Life Success: A Conceptual Model of Financial Well-Being for Young Adults

    Science.gov (United States)

    Shim, Soyeon; Xiao, Jing J.; Barber, Bonnie L.; Lyons, Angela C.

    2009-01-01

    The purpose of this study is to describe and test a conceptual model of the potential antecedents and consequences of financial well-being in young adulthood. Data (N = 781) were collected via an online survey conducted at a large state university in the southwestern United States. Our results suggest that self-actualizing personal values,…

  16. Student Success and the Family: Using the Comer Model for Home-School Connections.

    Science.gov (United States)

    Drake, Daniel D.

    1995-01-01

    Discusses the Comer Parents' Program Model, a structure to develop and plan effective parent-school partnerships. Describes the program's three levels (broad-based participation, parents-as-volunteers, and parents-as-decision-makers). Notes the need for a comprehensive plan. Discusses the four key elements of the plan: information exchange,…

  17. Highly reproducible polyol synthesis for silver nanocubes

    Science.gov (United States)

    Han, Hye Ji; Yu, Taekyung; Kim, Woo-Sik; Im, Sang Hyuk

    2017-07-01

    We could synthesize the Ag nanocubes highly reproducibly by conducting the polyol synthesis using HCl etchant in dark condition because the photodecomposition/photoreduction of AgCl nanoparticles formed at initial reaction stage were greatly depressed and consequently the selective self-nucleation of Ag single crystals and their selective growth reaction could be promoted. Whereas the reproducibility of the formation of Ag nanocubes were very poor when we synthesize the Ag nanocubes in light condition due to the photoreduction of AgCl to Ag.

  18. OL-DEC-MDP Model for Multiagent Online Scheduling with a Time-Dependent Probability of Success

    Directory of Open Access Journals (Sweden)

    Cheng Zhu

    2014-01-01

    Full Text Available Focusing on the on-line multiagent scheduling problem, this paper considers the time-dependent probability of success and processing duration and proposes an OL-DEC-MDP (opportunity loss-decentralized Markov Decision Processes model to include opportunity loss into scheduling decision to improve overall performance. The success probability of job processing as well as the process duration is dependent on the time at which the processing is started. The probability of completing the assigned job by an agent would be higher when the process is started earlier, but the opportunity loss could also be high due to the longer engaging duration. As a result, OL-DEC-MDP model introduces a reward function considering the opportunity loss, which is estimated based on the prediction of the upcoming jobs by a sampling method on the job arrival. Heuristic strategies are introduced in computing the best starting time for an incoming job by each agent, and an incoming job will always be scheduled to the agent with the highest reward among all agents with their best starting policies. The simulation experiments show that the OL-DEC-MDP model will improve the overall scheduling performance compared with models not considering opportunity loss in heavy-loading environment.

  19. Validation of prediction model for successful vaginal birth after Cesarean delivery based on sonographic assessment of hysterotomy scar.

    Science.gov (United States)

    Baranov, A; Salvesen, K Å; Vikhareva, O

    2018-02-01

    To validate a prediction model for successful vaginal birth after Cesarean delivery (VBAC) based on sonographic assessment of the hysterotomy scar, in a Swedish population. Data were collected from a prospective cohort study. We recruited non-pregnant women aged 18-35 years who had undergone one previous low-transverse Cesarean delivery at ≥ 37 gestational weeks and had had no other uterine surgery. Participants who subsequently became pregnant underwent transvaginal ultrasound examination of the Cesarean hysterotomy scar at 11 + 0 to 13 + 6 and at 19 + 0 to 21 + 6 gestational weeks. Thickness of the myometrium at the thinnest part of the scar area was measured. After delivery, information on pregnancy outcome was retrieved from hospital records. Individual probabilities of successful VBAC were calculated using a previously published model. Predicted individual probabilities were divided into deciles. For each decile, observed VBAC rates were calculated. To assess the accuracy of the prediction model, receiver-operating characteristics curves were constructed and the areas under the curves (AUC) were calculated. Complete sonographic data were available for 120 women. Eighty (67%) women underwent trial of labor after Cesarean delivery (TOLAC) with VBAC occurring in 70 (88%) cases. The scar was visible in all 80 women at the first-trimester scan and in 54 (68%) women at the second-trimester scan. AUC was 0.44 (95% CI, 0.28-0.60) among all women who underwent TOLAC and 0.51 (95% CI, 0.32-0.71) among those with the scar visible sonographically at both ultrasound examinations. The prediction model demonstrated poor accuracy for prediction of successful VBAC in our Swedish population. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.

  20. A model of a successful utilization of a high genetic potential of maize yield

    Directory of Open Access Journals (Sweden)

    Pavlov Milovan

    2008-01-01

    Full Text Available The principle of a system, defined as a ZP system, implying corresponding relationship among research, seed production and seed marketing, is that each segment within the system has its tasks and responsibilities, as well as, a clear interest. This system was established at the Maize Research Institute, Zemun Polje, almost half a century ago. The crucial characteristic is that this system encompasses obtained results of scientific accomplishments (patent - a released hybrid, optimal utilisation of the environmental conditions, facilities for seed drying, processing and packing, staff and transport capacities. The ZP system provides the economic interest of all participants in studies and the maize seed production. The fundamental base of the quality seed production within the ZP system is a multidisciplinary programme on maize breeding, as well as, 535 released hybrids with standard and specific traits. According to regulations in foreign countries, approximately 100 ZP maize hybrids have been released abroad. Agroecological conditions in Serbia are favorable for the development of the best genotypes and the production of basic and certified maize seed. There 10 processing plants that apply recent technologies in the maize seed processing procedure. Several generations of experts have been trained and gained experience within the maize seed production. Three seed testing laboratories have been accredited by the International Seed Testing Association. According to regulations in Serbia, monitoring of seed production under field conditions, and further on, during the processing practice is done only by designate authorities. This study presents one of successful systems of the seed production organization applicable in countries with similar conditions.

  1. When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis.

    Directory of Open Access Journals (Sweden)

    Jack W Scannell

    Full Text Available A striking contrast runs through the last 60 years of biopharmaceutical discovery, research, and development. Huge scientific and technological gains should have increased the quality of academic science and raised industrial R&D efficiency. However, academia faces a "reproducibility crisis"; inflation-adjusted industrial R&D costs per novel drug increased nearly 100 fold between 1950 and 2010; and drugs are more likely to fail in clinical development today than in the 1970s. The contrast is explicable only if powerful headwinds reversed the gains and/or if many "gains" have proved illusory. However, discussions of reproducibility and R&D productivity rarely address this point explicitly. The main objectives of the primary research in this paper are: (a to provide quantitatively and historically plausible explanations of the contrast; and (b identify factors to which R&D efficiency is sensitive. We present a quantitative decision-theoretic model of the R&D process. The model represents therapeutic candidates (e.g., putative drug targets, molecules in a screening library, etc. within a "measurement space", with candidates' positions determined by their performance on a variety of assays (e.g., binding affinity, toxicity, in vivo efficacy, etc. whose results correlate to a greater or lesser degree. We apply decision rules to segment the space, and assess the probability of correct R&D decisions. We find that when searching for rare positives (e.g., candidates that will successfully complete clinical development, changes in the predictive validity of screening and disease models that many people working in drug discovery would regard as small and/or unknowable (i.e., an 0.1 absolute change in correlation coefficient between model output and clinical outcomes in man can offset large (e.g., 10 fold, even 100 fold changes in models' brute-force efficiency. We also show how validity and reproducibility correlate across a population of simulated

  2. Determinants for a successful Sémont maneuver: an in-vitro study with a semicircular canal model

    Directory of Open Access Journals (Sweden)

    Dominik Obrist

    2016-09-01

    Full Text Available Objective: To evaluate the effect of time between the movements/steps, angle of body movements as well as the angular velocity of the maneuvers in an in-vitro model of a semicircular canal (SCC to improve the efficacy of the Sémont maneuver in benign paroxysmal positional vertigo (BPPV.Methods: Sémont maneuvers were performed on an in-vitro SCC model. Otoconia trajectories were captured by a video camera. The effects of time between the movements, angles of motion (0°, 10°, 20°, 30° below the horizontal line, different angular velocities (90, 135, 180°/s and otoconia size (36 and 50µm on the final position of the otoconia in the SCC were tested.Results: Without extension of the movements beyond the horizontal, the in-vitro experiments (with particles corresponding to 50 m diameter did not yield successful canalith repositioning. If the movements were extended by 20° beyond the horizontal position, Sémont maneuvers were successful with resting times of at least 16 s. For larger extension angles the required time decreased. However, for smaller particles (36 m the required time doubled. The angular maneuver velocity (tested between 90 and 180°/s did not have a major impact on the final position of the otoconia.Interpretation: The two primary determinants for success of the Sémont maneuver are the time between the movements and the extension of the movements beyond the horizontal. The time between the movements should be at least 45 s. Angles of 20° or more below horizontal line (so-called Sémont ++ should increase the success rate of SM.

  3. Application of Innovative Models in Teaching Methods for Introduction to Nature and Society and Students’ Success

    OpenAIRE

    Snezana Stavreva Veselinovska; Snezana Kirova

    2014-01-01

    This paper deals with the issue of shaping and applying innovative models in the teaching of Teaching methods for introduction to nature and society in the conditions existing in our schools. Most teachers need a modern methodical transformation of program contents for teaching nature and society. Therefore the theoretical part of the work is directed towards the consideration of innovative approaches in Teaching methods for introduction to nature and society, which asked for an indication of...

  4. Exergetic Model of Secondary Successions for Plant Communities in Arid Chaco (Argentina)

    OpenAIRE

    Karlin, Marcos; Galán, Rodrigo; Contreras, Ana; Zapata, Ricardo; Coirini, Rubén; Ruiz Posse, Eduardo

    2013-01-01

    Ecosystems are open systems where energy fluxes produce modifications over plant communities. According to the state and transition model, plant formations are defined by changes in natural conditions and disturbs. Based on these changes, it is possible to define vectors that show the tendencies of the communities towards other states. Within the subregion of Arid Chaco, mature communities of Aspidosperma quebracho blanco represent the quasistable equilibrium communities or “climax,” similar ...

  5. Andragogical Modeling and the Success of the "EMPACTS" project-based learning model in the STEM disciplines: A decade of growth and learner success in the 2Y College Learning Environment.

    Science.gov (United States)

    Phillips, C. D.; Thomason, R.; Galloway, M.; Sorey, N.; Stidham, L.; Torgerson, M.

    2014-12-01

    EMPACTS (Educationally Managed Projects Advancing Curriculum, Technology/Teamwork and Service) is a project-based, adult learning modelthat is designed to enhance learning of course content through real-world application and problem solving self directed and collaborative learning use of technology service to the community EMPACTS students are self-directed in their learning, often working in teams to develop, implement, report and present final project results. EMPACTS faculty use community based projects to increase deeper learning of course content through "real-world" service experiences. Learners develop personal and interpersonal work and communication skills as they plan, execute and complete project goals together. Technology is used as a tool to solve problems and to publish the products of their learning experiences. Courses across a broad STEM curriculum integrate the EMPACTS project experience into the overall learning outcomes as part of the learning college mission of preparing 2Y graduates for future academic and/or workforce success. Since the program began in 2005, there have been over 200 completed projects/year. Student driven successes have led to the establishment of an EMPACTS Technology Corp, which is funded through scholarship and allows EMPACTS learners the opportunity to serve and learn from one another as "peer instructors." Engineering and 3D graphic design teams have written technology proposals and received funding for 3D printing replication projects, which have benefited the college as a whole through grant opportunities tied to these small scale successes. EMPACTS students engage in a variety of outreachprojects with area schools as they share the successes and joys of self directed, inquiry, project based learning. The EMPACTS Program has successfully trained faculty and students in the implementation of the model and conduct semester to semester and once a year workshops for college and K-12 faculty, who are interested in

  6. Function-centered modeling of engineering systems using the goal tree-success tree technique and functional primitives

    International Nuclear Information System (INIS)

    Modarres, Mohammad; Cheon, Se Woo

    1999-01-01

    Most of the complex systems are formed through some hierarchical evolution. Therefore, those systems can be best described through hierarchical frameworks. This paper describes some fundamental attributes of complex physical systems and several hierarchies such as functional, behavioral, goal/condition, and event hierarchies, then presents a function-centered approach to system modeling. Based on the function-centered concept, this paper describes the joint goal tree-success tree (GTST) and the master logic diagram (MLD) as a framework for developing models of complex physical systems. A function-based lexicon for classifying the most common elements of engineering systems for use in the GTST-MLD framework has been proposed. The classification is based on the physical conservation laws that govern the engineering systems. Functional descriptions based on conservation laws provide a simple and rich vocabulary for modeling complex engineering systems

  7. From Model Minorities to Disposable Models: The De-Legitimisation of Educational Success through Discourses of Authenticity

    Science.gov (United States)

    Bradbury, Alice

    2013-01-01

    This article explores teachers' use of discourses of authenticity in relation to minoritised students, with a focus on the relationship between these discourses and "model minority" status. The paper aims to advance the critical thinking about "model minorities" in the education system in England by examining the diversity of…

  8. Measuring the Success of Library 2.0 Technologies in the African Context: The Suitability of the DeLone and McLean's Model

    Science.gov (United States)

    Lwoga, Edda Tandi

    2013-01-01

    Purpose: This study aims to examine the suitability of information systems (IS) success model in the adoption of library 2.0 technologies among undergraduate students in the African context, and focused at the Muhimbili University of Health and Allied Sciences (MUHAS) of Tanzania. Design/methodology/approach: Based on the IS success model, the…

  9. The Complete Solution of the Core-Periphery Model for two Regions using Successive Approximations

    Directory of Open Access Journals (Sweden)

    Catalin Angelo Ioan

    2012-02-01

    Full Text Available In this paper it is give the complete solution, using the Newton’s method of approximation,for the well known Krugman’s Core-Periphery model for two regions. After the process of reductionof the system of conditions, using appropriate substitutions, it is obtained one equation which is thekey of the problem’s solving. After the presentation of the iterative formula which gives the solution,the principal indicators (regional incomes, the prices indexes of manufactured goods and the realwage of workers are calculated.

  10. GROWTH AND SUCCESS POSSIBILITIES ON MICROENTERPRISES: AN ANALYSIS THROUGH LOGIT MODELS

    Directory of Open Access Journals (Sweden)

    David de Jesús González-Milán

    2016-01-01

    Full Text Available This paper studies the micro enterprises creation as unemployment solution, it ́s growth and impact at a national level. The hypothesis that holds the research affirms that there is growth in micro enterprises opening rate due to unemployment, increasing the activity at a national level. The methodology consisted of estimate a logistical model that allowed to confirm that there is a possitive relationship between the dependant variable and unemployment, due that marginal effects show that a discret change in unemployment increases the microenterprise ́s growht likelihood. Classification JEL: D22, L25, L26, L29.

  11. Estimating the reproducibility of psychological science

    NARCIS (Netherlands)

    Aarts, Alexander A.; Anderson, Joanna E.; Anderson, Christopher J.; Attridge, Peter R.; Attwood, Angela; Axt, Jordan; Babel, Molly; Bahník, Štěpán; Baranski, Erica; Barnett-Cowan, Michael; Bartmess, Elizabeth; Beer, Jennifer; Bell, Raoul; Bentley, Heather; Beyan, Leah; Binion, Grace; Borsboom, Denny; Bosch, Annick; Bosco, Frank A.; Bowman, Sara D.; Brandt, Mark J.; Braswell, Erin; Brohmer, Hilmar; Brown, Benjamin T.; Brown, Kristina; Brüning, Jovita; Calhoun-Sauls, Ann; Callahan, Shannon P.; Chagnon, Elizabeth; Chandler, Jesse; Chartier, Christopher R.; Cheung, Felix; Christopherson, Cody D.; Cillessen, Linda; Clay, Russ; Cleary, Hayley; Cloud, Mark D.; Conn, Michael; Cohoon, Johanna; Columbus, Simon; Cordes, Andreas; Costantini, Giulio; Alvarez, Leslie D Cramblet; Cremata, Ed; Crusius, Jan; DeCoster, Jamie; DeGaetano, Michelle A.; Penna, Nicolás Delia; Den Bezemer, Bobby; Deserno, Marie K.; Devitt, Olivia; Dewitte, Laura; Dobolyi, David G.; Dodson, Geneva T.; Donnellan, M. Brent; Donohue, Ryan; Dore, Rebecca A.; Dorrough, Angela; Dreber, Anna; Dugas, Michelle; Dunn, Elizabeth W.; Easey, Kayleigh; Eboigbe, Sylvia; Eggleston, Casey; Embley, Jo; Epskamp, Sacha; Errington, Timothy M.; Estel, Vivien; Farach, Frank J.; Feather, Jenelle; Fedor, Anna; Fernández-Castilla, Belén; Fiedler, Susann; Field, James G.; Fitneva, Stanka A.; Flagan, Taru; Forest, Amanda L.; Forsell, Eskil; Foster, Joshua D.; Frank, Michael C.; Frazier, Rebecca S.; Fuchs, Heather; Gable, Philip; Galak, Jeff; Galliani, Elisa Maria; Gampa, Anup; Garcia, Sara; Gazarian, Douglas; Gilbert, Elizabeth; Giner-Sorolla, Roger; Glöckner, Andreas; Goellner, Lars; Goh, Jin X.; Goldberg, Rebecca; Goodbourn, Patrick T.; Gordon-McKeon, Shauna; Gorges, Bryan; Gorges, Jessie; Goss, Justin; Graham, Jesse; Grange, James A.; Gray, Jeremy; Hartgerink, Chris; Hartshorne, Joshua; Hasselman, Fred; Hayes, Timothy; Heikensten, Emma; Henninger, Felix; Hodsoll, John; Holubar, Taylor; Hoogendoorn, Gea; Humphries, Denise J.; Hung, Cathy O Y; Immelman, Nathali; Irsik, Vanessa C.; Jahn, Georg; Jäkel, Frank; Jekel, Marc; Johannesson, Magnus; Johnson, Larissa G.; Johnson, David J.; Johnson, Kate M.; Johnston, William J.; Jonas, Kai; Joy-Gaba, Jennifer A.; Kappes, Heather Barry; Kelso, Kim; Kidwell, Mallory C.; Kim, Seung Kyung; Kirkhart, Matthew; Kleinberg, Bennett; Knežević, Goran; Kolorz, Franziska Maria; Kossakowski, Jolanda J.; Krause, Robert Wilhelm; Krijnen, Job; Kuhlmann, Tim; Kunkels, Yoram K.; Kyc, Megan M.; Lai, Calvin K.; Laique, Aamir; Lakens, Daniël; Lane, Kristin A.; Lassetter, Bethany; Lazarević, Ljiljana B.; Le Bel, Etienne P.; Lee, Key Jung; Lee, Minha; Lemm, Kristi; Levitan, Carmel A.; Lewis, Melissa; Lin, Lin; Lin, Stephanie; Lippold, Matthias; Loureiro, Darren; Luteijn, Ilse; MacKinnon, Sean; Mainard, Heather N.; Marigold, Denise C.; Martin, Daniel P.; Martinez, Tylar; Masicampo, E. J.; Matacotta, Josh; Mathur, Maya; May, Michael; Mechin, Nicole; Mehta, Pranjal; Meixner, Johannes; Melinger, Alissa; Miller, Jeremy K.; Miller, Mallorie; Moore, Katherine; Möschl, Marcus; Motyl, Matt; Müller, Stephanie M.; Munafo, Marcus; Neijenhuijs, Koen I.; Nervi, Taylor; Nicolas, Gandalf; Nilsonne, Gustav; Nosek, Brian A.; Nuijten, Michèle B.; Olsson, Catherine; Osborne, Colleen; Ostkamp, Lutz; Pavel, Misha; Penton-Voak, Ian S.; Perna, Olivia; Pernet, Cyril; Perugini, Marco; Pipitone, R. Nathan; Pitts, Michael C.; Plessow, Franziska; Prenoveau, Jason M.; Rahal, Rima Maria; Ratliff, Kate A.; Reinhard, David; Renkewitz, Frank; Ricker, Ashley A.; Rigney, Anastasia; Rivers, Andrew M.; Roebke, Mark; Rutchick, Abraham M.; Ryan, Robert S.; Sahin, Onur; Saide, Anondah; Sandstrom, Gillian M.; Santos, David; Saxe, Rebecca; Schlegelmilch, René; Schmidt, Kathleen; Scholz, Sabine; Seibel, Larissa; Selterman, Dylan Faulkner; Shaki, Samuel; Simpson, William B.; Sinclair, H. Colleen; Skorinko, Jeanine L M; Slowik, Agnieszka; Snyder, Joel S.; Soderberg, Courtney; Sonnleitner, Carina; Spencer, Nick; Spies, Jeffrey R.; Steegen, Sara; Stieger, Stefan; Strohminger, Nina; Sullivan, Gavin B.; Talhelm, Thomas; Tapia, Megan; Te Dorsthorst, Anniek; Thomae, Manuela; Thomas, Sarah L.; Tio, Pia; Traets, Frits; Tsang, Steve; Tuerlinckx, Francis; Turchan, Paul; Valášek, Milan; Van't Veer, Anna E.; Van Aert, Robbie; Van Assen, Marcel; Van Bork, Riet; Van De Ven, Mathijs; Van Den Bergh, Don; Van Der Hulst, Marije; Van Dooren, Roel; Van Doorn, Johnny; Van Renswoude, Daan R.; Van Rijn, Hedderik; Vanpaemel, Wolf; Echeverría, Alejandro Vásquez; Vazquez, Melissa; Velez, Natalia; Vermue, Marieke; Verschoor, Mark; Vianello, Michelangelo; Voracek, Martin; Vuu, Gina; Wagenmakers, Eric-Jan; Weerdmeester, Joanneke; Welsh, Ashlee; Westgate, Erin C.; Wissink, Joeri; Wood, Michael; Woods, Andy; Wright, Emily; Wu, Sining; Zeelenberg, Marcel; Zuni, Kellylynn

    2015-01-01

    Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available.

  12. Estimating the reproducibility of psychological science

    NARCIS (Netherlands)

    Aarts, Alexander A.; Anderson, Joanna E.; Anderson, Christopher J.; Attridge, Peter R.; Attwood, Angela; Axt, Jordan; Babel, Molly; Bahnik, Stepan; Baranski, Erica; Barnett-Cowan, Michael; Bartmess, Elizabeth; Beer, Jennifer; Bell, Raoul; Bentley, Heather; Beyan, Leah; Binion, Grace; Borsboom, Denny; Bosch, Annick; Bosco, Frank A.; Bowman, Sara D.; Brandt, Mark J.; Braswell, Erin; Brohmer, Hilmar; Brown, Benjamin T.; Brown, Kristina; Bruening, Jovita; Calhoun-Sauls, Ann; Chagnon, Elizabeth; Callahan, Shannon P.; Chandler, Jesse; Chartier, Christopher R.; Cheung, Felix; Cillessen, Linda; Christopherson, Cody D.; Clay, Russ; Cleary, Hayley; Cloud, Mark D.; Cohn, Michael; Cohoon, Johanna; Columbus, Simon; Cordes, Andreas; Costantini, Giulio; Hartgerink, Chris; Krijnen, Job; Nuijten, Michele B.; van 't Veer, Anna E.; Van Aert, Robbie; van Assen, M.A.L.M.; Wissink, Joeri; Zeelenberg, Marcel

    2015-01-01

    INTRODUCTION Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. Scientific claims should not gain credence because of the status or authority of their originator but by the replicability of their supporting evidence. Even research

  13. REPRODUCIBILITY OF CHILDHOOD RESPIRATORY SYMPTOM QUESTIONS

    NARCIS (Netherlands)

    BRUNEKREEF, B; GROOT, B; RIJCKEN, B; HOEK, G; STEENBEKKERS, A; DEBOER, A

    The reproducibility of answers to childhood respiratory symptom questions was investigated by administering two childhood respiratory symptom questionnaires twice, with a one month interval, to the same population of Dutch school children. The questionnaires were completed by the parents of 410

  14. Reply to the comment of S. Rayne on "QSAR model reproducibility and applicability: A case study of rate constants of hydroxyl radical reaction models applied to polybrominated diphenyl ethers and (benzo-)triazoles".

    Science.gov (United States)

    Gramatica, Paola; Kovarich, Simona; Roy, Partha Pratim

    2013-07-30

    We appreciate the interest of Dr. Rayne on our article and we completely agree that the dataset of (benzo-)triazoles, which were screened by the hydroxyl radical reaction quantitative structure-activity relationship (QSAR) model, was not only composed of benzo-triazoles but also included some simpler triazoles (without the condensed benzene ring), such as the chemicals listed by Dr. Rayne, as well as some related heterocycles (also few not aromatic). We want to clarify that in this article (as well as in other articles in which the same dataset was screened), for conciseness, the abbreviations (B)TAZs and BTAZs were used as general (and certainly too simplified) notations meaning an extended dataset of benzo-triazoles, triazoles, and related compounds. Copyright © 2013 Wiley Periodicals, Inc.

  15. A South African public-private partnership HIV treatment model: viability and success factors.

    Science.gov (United States)

    Igumbor, Jude; Pascoe, Sophie; Rajap, Shuabe; Townsend, Wendy; Sargent, John; Darkoh, Ernest

    2014-01-01

    The increasing number of people requiring HIV treatment in South Africa calls for efficient use of its human resources for health in order to ensure optimum treatment coverage and outcomes. This paper describes an innovative public-private partnership model which uses private sector doctors to treat public sector patients and ascertains the model's ability to maintain treatment outcomes over time. The study used a retrospective design based on the electronic records of patients who were down-referred from government hospitals to selected private general medical practitioners (GPs) between November 2005 and October 2012. In total, 2535 unique patient records from 40 GPs were reviewed. The survival functions for mortality and attrition were calculated. Cumulative incidence of mortality for different time cohorts (defined by year of treatment initiation) was also established. The median number of patients per GP was 143 (IQR: 66-246). At the time of down-referral to private GPs, 13.8% of the patients had CD4 count private sector based programme can be effectively and efficiently used to either target specific health concerns, key populations or serve as a stop-gap measure to meet urgent health needs.

  16. Recent successes and emerging challenges for coordinated satellite/ground-based magnetospheric exploration and modeling.

    Science.gov (United States)

    Angelopoulos, Vassilis

    With the availability of a distributed constellation of spacecraft (THEMIS, Geotail, Cluster) and increased capability ground based arrays (SuperDARN, THEMIS/GBOs), it is now pos-sible to infer simply from timing significant information regarding mapping of magnetospheric phenomena. Optical, magnetometer and radar data can pinpoint the location and nature of onset signatures. On the other hand, magnetic field modeling constrained by physical bound-aries (such as the isotropy boundary) the measured magnetic field and total pressure values at a distibuted network of satellites has proven to do a much better job at correlating ionospheric precipitation and diffuse auroral boundaries to magnetospheric phenomena, such as the inward boundary of the dipolarization fronts. It is now possible to routinely compare in-situ measured phase space densities of ion and electron distributions during ionosphere -magnetosphere con-junctions, in the absense of potential drops. It is also possible to not only infer equivalent current systems from the ground, but use reconstruction of the ionospheric current system from space to determine the full electrodynamics evolution of the ionosphere and compare with radars. Assimilation of this emerging ground based and global magnetospheric panoply into a self consistent magnetospheric model will likely be one of the most fruitful endeavors in magnetospheric exploration during the next few years.

  17. The successful, rapid transition to a new model of graduate medical education in Singapore.

    Science.gov (United States)

    Huggan, Paul J; Samarasekara, Dujeepa D; Archuleta, Sophia; Khoo, See Meng; Sim, Joe Heng Joo; Sin, Clara Siew Ping; Ooi, Shirley Beng Suat

    2012-09-01

    Graduate medical education (GME) in Singapore recently underwent major reform (2009-2012), leading to accreditation of residency programs by the Accreditation Council for Graduate Medical Education-International (ACGME-I) within two years of the initial commitment to change. The main aims of the reforms were to implement best practices in GME, to provide better support structures for program administration, and to bring all specialty training under one administrative umbrella. The authors outline the historic development of GME in Singapore, the complexities of the model in place immediately prior to ACGME-I accreditation, and the difficulties addressed by the proposed changes, leading to a description of implementation efforts at the National University Hospital of Singapore, a university-affiliated academic medical center. The authors describe the institutional factors uniting hospital leaders in support of reform, the recruitment of a team to manage change within the institution, the inauguration of a new office for GME, and the faculty development initiatives needed to educate faculty leading the change process. The preparation and execution of specific initiatives designed to improve GME and the communication strategies needed to coordinate and publicize change efforts are outlined, as well as strategies for sustaining improvements and building them into the culture of the institution. The authors demonstrate that external accreditation can be a powerful driver of educational reform and summarize key lessons derived from Kotter principles, a current model of change management.

  18. Modeling position-specific isotope fractionation of organic micropollutants degradation via different reaction pathways

    DEFF Research Database (Denmark)

    Jin, Biao; Rolle, Massimo

    : dichlorobenzamide (BAM), isoproturon (IPU) and diclofenac (DCF). The model successfully reproduces the multi-element isotope data, and precisely captures the dual element isotope trends, characterizing the different degradation pathways. Besides illustrating the model capability of mechanistic evaluation...

  19. Restless led syndrome model Drosophila melanogaster show successful olfactory learning and 1-day retention of the acquired memory

    Directory of Open Access Journals (Sweden)

    Mika F. Asaba

    2013-09-01

    Full Text Available Restless Legs Syndrome (RLS is a prevalent but poorly understood disorder that ischaracterized by uncontrollable movements during sleep, resulting in sleep disturbance.Olfactory memory in Drosophila melanogaster has proven to be a useful tool for the study ofcognitive deficits caused by sleep disturbances, such as those seen in RLS. A recently generatedDrosophila model of RLS exhibited disturbed sleep patterns similar to those seen in humans withRLS. This research seeks to improve understanding of the relationship between cognitivefunctioning and sleep disturbances in a new model for RLS. Here, we tested learning andmemory in wild type and dBTBD9 mutant flies by Pavlovian olfactory conditioning, duringwhich a shock was paired with one of two odors. Flies were then placed in a T-maze with oneodor on either side, and successful associative learning was recorded when the flies chose theside with the unpaired odor. We hypothesized that due to disrupted sleep patterns, dBTBD9mutant flies would be unable to learn the shock-odor association. However, the current studyreports that the recently generated Drosophila model of RLS shows successful olfactorylearning, despite disturbed sleep patterns, with learning performance levels matching or betterthan wild type flies.

  20. ITK: enabling reproducible research and open science

    Science.gov (United States)

    McCormick, Matthew; Liu, Xiaoxiao; Jomier, Julien; Marion, Charles; Ibanez, Luis

    2014-01-01

    Reproducibility verification is essential to the practice of the scientific method. Researchers report their findings, which are strengthened as other independent groups in the scientific community share similar outcomes. In the many scientific fields where software has become a fundamental tool for capturing and analyzing data, this requirement of reproducibility implies that reliable and comprehensive software platforms and tools should be made available to the scientific community. The tools will empower them and the public to verify, through practice, the reproducibility of observations that are reported in the scientific literature. Medical image analysis is one of the fields in which the use of computational resources, both software and hardware, are an essential platform for performing experimental work. In this arena, the introduction of the Insight Toolkit (ITK) in 1999 has transformed the field and facilitates its progress by accelerating the rate at which algorithmic implementations are developed, tested, disseminated and improved. By building on the efficiency and quality of open source methodologies, ITK has provided the medical image community with an effective platform on which to build a daily workflow that incorporates the true scientific practices of reproducibility verification. This article describes the multiple tools, methodologies, and practices that the ITK community has adopted, refined, and followed during the past decade, in order to become one of the research communities with the most modern reproducibility verification infrastructure. For example, 207 contributors have created over 2400 unit tests that provide over 84% code line test coverage. The Insight Journal, an open publication journal associated with the toolkit, has seen over 360,000 publication downloads. The median normalized closeness centrality, a measure of knowledge flow, resulting from the distributed peer code review system was high, 0.46. PMID:24600387

  1. ITK: Enabling Reproducible Research and Open Science

    Directory of Open Access Journals (Sweden)

    Matthew Michael McCormick

    2014-02-01

    Full Text Available Reproducibility verification is essential to the practice of the scientific method. Researchers report their findings, which are strengthened as other independent groups in the scientific community share similar outcomes. In the many scientific fields where software has become a fundamental tool for capturing and analyzing data, this requirement of reproducibility implies that reliable and comprehensive software platforms and tools should be made available to the scientific community. The tools will empower them and the public to verify, through practice, the reproducibility of observations that are reported in the scientific literature.Medical image analysis is one of the fields in which the use of computational resources, both software and hardware, are an essential platform for performing experimental work. In this arena, the introduction of the Insight Toolkit (ITK in 1999 has transformed the field and facilitates its progress by accelerating the rate at which algorithmic implementations are developed, tested, disseminated and improved. By building on the efficiency and quality of open source methodologies, ITK has provided the medical image community with an effective platform on which to build a daily workflow that incorporates the true scientific practices of reproducibility verification.This article describes the multiple tools, methodologies, and practices that the ITK community has adopted, refined, and followed during the past decade, in order to become one of the research communities with the most modern reproducibility verification infrastructure. For example, 207 contributors have created over 2400 unit tests that provide over 84% code line test coverage. The Insight Journal, an open publication journal associated with the toolkit, has seen over 360,000 publication downloads. The median normalized closeness centrality, a measure of knowledge flow, resulting from the distributed peer code review system was high, 0.46.

  2. A PHYSICAL ACTIVITY QUESTIONNAIRE: REPRODUCIBILITY AND VALIDITY

    Directory of Open Access Journals (Sweden)

    Nicolas Barbosa

    2007-12-01

    Full Text Available This study evaluates the Quantification de L'Activite Physique en Altitude chez les Enfants (QAPACE supervised self-administered questionnaire reproducibility and validity on the estimation of the mean daily energy expenditure (DEE on Bogotá's schoolchildren. The comprehension was assessed on 324 students, whereas the reproducibility was studied on a different random sample of 162 who were exposed twice to it. Reproducibility was assessed using both the Bland-Altman plot and the intra-class correlation coefficient (ICC. The validity was studied in a sample of 18 girls and 18 boys randomly selected, which completed the test - re-test study. The DEE derived from the questionnaire was compared with the laboratory measurement results of the peak oxygen uptake (Peak VO2 from ergo-spirometry and Leger Test. The reproducibility ICC was 0.96 (95% C.I. 0.95-0.97; by age categories 8-10, 0.94 (0.89-0. 97; 11-13, 0.98 (0.96- 0.99; 14-16, 0.95 (0.91-0.98. The ICC between mean TEE as estimated by the questionnaire and the direct and indirect Peak VO2 was 0.76 (0.66 (p<0.01; by age categories, 8-10, 11-13, and 14-16 were 0.89 (0.87, 0.76 (0.78 and 0.88 (0.80 respectively. The QAPACE questionnaire is reproducible and valid for estimating PA and showed a high correlation with the Peak VO2 uptake

  3. Supporting the Evaluation and Implementation of Musculoskeletal Models of Care: A Globally Informed Framework for Judging Readiness and Success.

    Science.gov (United States)

    Briggs, Andrew M; Jordan, Joanne E; Jennings, Matthew; Speerin, Robyn; Bragge, Peter; Chua, Jason; Woolf, Anthony D; Slater, Helen

    2017-04-01

    To develop a globally informed framework to evaluate readiness for implementation and success after implementation of musculoskeletal models of care (MOCs). Three phases were undertaken: 1) a qualitative study with 27 Australian subject matter experts (SMEs) to develop a draft framework; 2) an eDelphi study with an international panel of 93 SMEs across 30 nations to evaluate face validity, and refine and establish consensus on the framework components; and 3) translation of the framework into a user-focused resource and evaluation of its acceptability with the eDelphi panel. A comprehensive evaluation framework was developed for judging the readiness and success of musculoskeletal MOCs. The framework consists of 9 domains, with each domain containing a number of themes underpinned by detailed elements. In the first Delphi round, scores of "partly agree" or "completely agree" with the draft framework ranged 96.7%-100%. In the second round, "essential" scores ranged 58.6%-98.9%, resulting in 14 of 34 themes being classified as essential. SMEs strongly agreed or agreed that the final framework was useful (98.8%), usable (95.1%), credible (100%) and appealing (93.9%). Overall, 96.3% strongly supported or supported the final structure of the framework as it was presented, while 100%, 96.3%, and 100% strongly supported or supported the content within the readiness, initiating implementation, and success streams, respectively. An empirically derived framework to evaluate the readiness and success of musculoskeletal MOCs was strongly supported by an international panel of SMEs. The framework provides an important internationally applicable benchmark for the development, implementation, and evaluation of musculoskeletal MOCs. © 2016, American College of Rheumatology.

  4. A stepwise approach for the reproducible optimization of PAMO expression in Escherichia coli for whole-cell biocatalysis

    Directory of Open Access Journals (Sweden)

    van Bloois Edwin

    2012-06-01

    Full Text Available Abstract Background Baeyer-Villiger monooxygenases (BVMOs represent a group of enzymes of considerable biotechnological relevance as illustrated by their growing use as biocatalyst in a variety of synthetic applications. However, due to their increased use the reproducible expression of BVMOs and other biotechnologically relevant enzymes has become a pressing matter while knowledge about the factors governing their reproducible expression is scattered. Results Here, we have used phenylacetone monooxygenase (PAMO from Thermobifida fusca, a prototype Type I BVMO, as a model enzyme to develop a stepwise strategy to optimize the biotransformation performance of recombinant E. coli expressing PAMO in 96-well microtiter plates in a reproducible fashion. Using this system, the best expression conditions of PAMO were investigated first, including different host strains, temperature as well as time and induction period for PAMO expression. This optimized system was used next to improve biotransformation conditions, the PAMO-catalyzed conversion of phenylacetone, by evaluating the best electron donor, substrate concentration, and the temperature and length of biotransformation. Combining all optimized parameters resulted in a more than four-fold enhancement of the biocatalytic performance and, importantly, this was highly reproducible as indicated by the relative standard deviation of 1% for non-washed cells and 3% for washed cells. Furthermore, the optimized procedure was successfully adapted for activity-based mutant screening. Conclusions Our optimized procedure, which provides a comprehensive overview of the key factors influencing the reproducible expression and performance of a biocatalyst, is expected to form a rational basis for the optimization of miniaturized biotransformations and for the design of novel activity-based screening procedures suitable for BVMOs and other NAD(PH-dependent enzymes as well.

  5. A stepwise approach for the reproducible optimization of PAMO expression in Escherichia coli for whole-cell biocatalysis.

    Science.gov (United States)

    van Bloois, Edwin; Dudek, Hanna M; Duetz, Wouter A; Fraaije, Marco W

    2012-06-21

    Baeyer-Villiger monooxygenases (BVMOs) represent a group of enzymes of considerable biotechnological relevance as illustrated by their growing use as biocatalyst in a variety of synthetic applications. However, due to their increased use the reproducible expression of BVMOs and other biotechnologically relevant enzymes has become a pressing matter while knowledge about the factors governing their reproducible expression is scattered. Here, we have used phenylacetone monooxygenase (PAMO) from Thermobifida fusca, a prototype Type I BVMO, as a model enzyme to develop a stepwise strategy to optimize the biotransformation performance of recombinant E. coli expressing PAMO in 96-well microtiter plates in a reproducible fashion. Using this system, the best expression conditions of PAMO were investigated first, including different host strains, temperature as well as time and induction period for PAMO expression. This optimized system was used next to improve biotransformation conditions, the PAMO-catalyzed conversion of phenylacetone, by evaluating the best electron donor, substrate concentration, and the temperature and length of biotransformation. Combining all optimized parameters resulted in a more than four-fold enhancement of the biocatalytic performance and, importantly, this was highly reproducible as indicated by the relative standard deviation of 1% for non-washed cells and 3% for washed cells. Furthermore, the optimized procedure was successfully adapted for activity-based mutant screening. Our optimized procedure, which provides a comprehensive overview of the key factors influencing the reproducible expression and performance of a biocatalyst, is expected to form a rational basis for the optimization of miniaturized biotransformations and for the design of novel activity-based screening procedures suitable for BVMOs and other NAD(P)H-dependent enzymes as well.

  6. Floodplain forest succession reveals fluvial processes: A hydrogeomorphic model for temperate riparian woodlands.

    Science.gov (United States)

    Egger, Gregory; Politti, Emilio; Lautsch, Erwin; Benjankar, Rohan; Gill, Karen M; Rood, Stewart B

    2015-09-15

    River valley floodplains are physically-dynamic environments where fluvial processes determine habitat gradients for riparian vegetation. These zones support trees and shrubs whose life stages are adapted to specific habitat types and consequently forest composition and successional stage reflect the underlying hydrogeomorphic processes and history. In this study we investigated woodland vegetation composition, successional stage and habitat properties, and compared these with physically-based indicators of hydraulic processes. We thus sought to develop a hydrogeomorphic model to evaluate riparian woodland condition based on the spatial mosaic of successional phases of the floodplain forest. The study investigated free-flowing and dam-impacted reaches of the Kootenai and Flathead Rivers, in Idaho and Montana, USA and British Columbia, Canada. The analyses revealed strong correspondence between vegetation assessments and metrics of fluvial processes indicating morphodynamics (erosion and shear stress), inundation and depth to groundwater. The results indicated that common successional stages generally occupied similar hydraulic environments along the different river segments. Comparison of the spatial patterns between the free-flowing and regulated reaches revealed greater deviation from the natural condition for the braided channel segment than for the meandering segment. This demonstrates the utility of the hydrogeomorphic approach and suggests that riparian woodlands along braided channels could have lower resilience than those along meandering channels and might be more vulnerable to influences such as from river damming or climate change. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Successive Student Cohorts and Longitudinal Growth Models: An Investigation of Elementary School Mathematics Performance

    Directory of Open Access Journals (Sweden)

    Keith Zvoch

    2006-01-01

    Full Text Available Mathematics achievement data from three longitudinally matched student cohorts were analyzed with multilevel growth models to investigate the viability of using status and growth-based indices of student achievement to examine the multi-year performance of schools. Elementary schools in a large southwestern school district were evaluated in terms of the mean achievement status and growth of students across cohorts as well as changes in the achievement status and growth of students between student cohorts. Results indicated that the cross and between-cohort performance of schools differed depending on whether the mean achievement status or growth of students was considered. Results also indicated that the cross-cohort indicators of school performance were more reliably estimated than their between-cohort counterparts. Further examination of the performance indices revealed that cross-cohort achievement status estimates were closely related to student demographics while between-cohort estimates were associated with cohort enrollment size and cohort initial performance status. Of the four school performance indices studied, only student growth in achievement (averaged across cohorts provided a relatively reliable and unbiased indication of school performance. Implications for the No Child Left Behind school accountability framework are discussed.

  8. Sustainable business models: systematic approach toward successful ambulatory care pharmacy practice.

    Science.gov (United States)

    Sachdev, Gloria

    2014-08-15

    This article discusses considerations for making ambulatory care pharmacist services at least cost neutral and, ideally, generate a margin that allows for service expansion. The four pillars of business sustainability are leadership, staffing, information technology, and compensation. A key facet of leadership in ambulatory care pharmacy practice is creating and expressing a clear vision for pharmacists' services. Staffing considerations include establishing training needs, maximizing efficiencies, and minimizing costs. Information technology is essential for efficiency in patient care delivery and outcomes assessment. The three domains of compensation are cost savings, pay for performance, and revenue generation. The following eight steps for designing and implementing an ambulatory care pharmacist service are discussed: (1) prepare a needs assessment, (2) analyze existing strengths, weaknesses, opportunities, and threats, (3) analyze service gaps and feasibility, (4) consider financial opportunities, (5) consider stakeholders' interests, (6) develop a business plan, (7) implement the service, and (8) measure outcomes. Potential future changes in national healthcare policy (such as pharmacist provider status and expanded pay for performance) could enhance the opportunities for sustainable ambulatory care pharmacy practice. The key challenges facing ambulatory care pharmacists are developing sustainable business models, determining which services yield a positive return on investment, and demanding payment for value-added services. Copyright © 2014 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

  9. Waste-efficient materials procurement for construction projects: A structural equation modelling of critical success factors.

    Science.gov (United States)

    Ajayi, Saheed O; Oyedele, Lukumon O

    2018-05-01

    Albeit the understanding that construction waste is caused by activities ranging from all stages of project delivery process, research efforts have been concentrated on design and construction stages, while the possibility of reducing waste through materials procurement process is widely neglected. This study aims at exploring and confirming strategies for achieving waste-efficient materials procurement in construction activities. The study employs sequential exploratory mixed method approach as its methodological framework, using focus group discussion, statistical analysis and structural equation modelling. The study suggests that for materials procurement to enhance waste minimisation in construction projects, the procurement process would be characterised by four features. These include suppliers' commitment to low waste measures, low waste purchase management, effective materials delivery management and waste-efficient Bill of Quantity, all of which have significant impacts on waste minimisation. This implies that commitment of materials suppliers to such measures as take back scheme and flexibility in supplying small materials quantity, among others, are expected of materials procurement. While low waste purchase management stipulates the need for such measures as reduced packaging and consideration of pre-assembled/pre-cut materials, efficient delivery management entails effective delivery and storage system as well as adequate protection of materials during the delivery process, among others. Waste-efficient specification and bill of quantity, on the other hand, requires accurate materials take-off and ordering of materials based on accurately prepared design documents and bill of quantity. Findings of this study could assist in understanding a set of measures that should be taken during materials procurement process, thereby corroborating waste management practices at other stages of project delivery process. Copyright © 2018. Published by Elsevier Ltd.

  10. Linking Formal and Informal Science Education: A Successful Model using Libraries, Volunteers and NASA Resources

    Science.gov (United States)

    Race, M. S.; Lafayette Library; Learning Center Foundation (Lllcf)

    2011-12-01

    In these times of budget cuts, tight school schedules, and limited opportunities for student field trips and teacher professional development, it is especially difficult to expose elementary and middle school students to the latest STEM information-particularly in the space sciences. Using our library as a facilitator and catalyst, we built a volunteer-based, multi-faceted, curriculum-linked program for students and teachers in local middle schools (Grade 8) and showcased new astronomical and planetary science information using mainly NASA resources and volunteer effort. The project began with the idea of bringing free NASA photo exhibits (FETTU) to the Lafayette and Antioch Libraries for public display. Subsequently, the effort expanded by adding layers of activities that brought space and science information to teachers, students and the pubic at 5 libraries and schools in the 2 cities, one of which serves a diverse, underserved community. Overall, the effort (supported by a pilot grant from the Bechtel Foundation) included school and library based teacher workshops with resource materials; travelling space museum visits with hands-on activities (Chabot-to-Go); separate powerpoint presentations for students and adults at the library; and concurrent ancillary space-related themes for young children's programs at the library. This pilot project, based largely on the use of free government resources and online materials, demonstrated that volunteer-based, standards-linked STEM efforts can enhance curriculum at the middle school, with libraries serving a special role. Using this model, we subsequently also obtained a small NASA-Space Grant award to bring star parties and hand-on science activities to three libraries this Fall, linking with numerous Grade 5 teachers and students in two additional underserved areas of our county. It's not necessary to reinvent the wheel, you just collect the pieces and build on what you already have.

  11. Co-production and modeling landscape change - successes and challenges in developing useful climate science

    Science.gov (United States)

    Timm, K.; Reynolds, J.; Littell, J. S.; Murphy, K.; Euskirchen, E. S.; Breen, A. L.; Gray, S. T.; McGuire, A. D.; Rupp, S. T.

    2017-12-01

    Responding to the impacts of climate change and generating information that helps inform resource management requires exceptional communication and collaboration among researchers, managers, and other stakeholders. However, there is relatively little guidance on how to practically develop, facilitate, and evaluate this process given the highly specific and localized nature of many co-production efforts in terms of information needs, research questions, partners, and associated institutions. The Integrated Ecosystem Model (IEM) for Alaska and Northwest Canada was developed to understand how climate change influences interactions among disturbance (e.g. wildfire, thermokarst), permafrost, hydrology, and vegetation and identify how these changes affect valuable ecosystem services. The IEM was a unique co-production effort in that it was driven by broad management interests (rather than one research question), and because of the landscape-scale outputs, much broader engagement was warranted. Communication between the research team and the broader community of resource managers was facilitated by the Alaska Landscape Conservation Cooperatives and the Alaska Climate Science Center. Team members' reflections on the project confirm the importance of deliberate approaches to collaboration, where everyone has frequent opportunities to discuss goals, assumptions, and presumed outcomes of the project itself, as well as the elements of the process (i.e. meetings, reports, etc.). However, managing these activities requires significant time, resources, and perhaps more dedicated personnel. The lessons learned from the design and application of the IEM are highly relevant to researchers and land managers in other regions that are considering the development of a similar tool or an undertaking of similar magnitude, scale, and complexity.

  12. Evaluation of a comprehensive EHR based on the DeLone and McLean model for IS Success: Approach, Results, and Success Factors

    DEFF Research Database (Denmark)

    Bossen, Claus; Jensen, Lotte Groth; Udsen, Flemming Witt

    2013-01-01

    Objective: The article describes the methodological approach to, and results of an evaluation of a comprehensive electronic health record (EHR) in the shake down phase, shortly after its implementation at a regional hospital in Denmark. Design: A formative evaluation based on a mixed-methods case...... study, designed to be interactive and concurrent was conducted at two hospital departments based on the updated DeLone and McLean framework for evaluating information systems success. Methods: To ascertain user assessments of the EHR, we distributed a questionnaire two months after implementation......:Overall, staff had positive experiences with the EHR and its operational reliability, response time, login and support. Performance was acceptable. Medical secretaries found the use of the patient administration module cumbersome, and physicians found the establishment of the overview of professionally...

  13. Accuracy, reproducibility, and time efficiency of dental measurements using different technologies.

    Science.gov (United States)

    Grünheid, Thorsten; Patel, Nishant; De Felippe, Nanci L; Wey, Andrew; Gaillard, Philippe R; Larson, Brent E

    2014-02-01

    Historically, orthodontists have taken dental measurements on plaster models. Technological advances now allow orthodontists to take these measurements on digital models. In this study, we aimed to assess the accuracy, reproducibility, and time efficiency of dental measurements taken on 3 types of digital models. emodels (GeoDigm, Falcon Heights, Minn), SureSmile models (OraMetrix, Richardson, Tex), and AnatoModels (Anatomage, San Jose, Calif) were made for 30 patients. Mesiodistal tooth-width measurements taken on these digital models were timed and compared with those on the corresponding plaster models, which were used as the gold standard. Accuracy and reproducibility were assessed using the Bland-Altman method. Differences in time efficiency were tested for statistical significance with 1-way analysis of variance. Measurements on SureSmile models were the most accurate, followed by those on emodels and AnatoModels. Measurements taken on SureSmile models were also the most reproducible. Measurements taken on SureSmile models and emodels were significantly faster than those taken on AnatoModels and plaster models. Tooth-width measurements on digital models can be as accurate as, and might be more reproducible and significantly faster than, those taken on plaster models. Of the models studied, the SureSmile models provided the best combination of accuracy, reproducibility, and time efficiency of measurement. Copyright © 2014 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

  14. Reproducibility of the chamber scarification test

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner

    1996-01-01

    The chamber scarification test is a predictive human skin irritation test developed to rank the irritation potential of products and ingredients meant for repeated use on normal and diseased skin. 12 products or ingredients can be tested simultaneously on the forearm skin of each volunteer....... The test combines with the procedure scratching of the skin at each test site and subsequent closed patch tests with the products, repeated daily for 3 days. The test is performed on groups of human volunteers: a skin irritant substance or products is included in each test as a positive control...... high reproducibility of the test. Further, intra-individual variation in skin reaction to the 2 control products in 26 volunteers, who participated 2x, is shown, which supports the conclusion that the chamber scarification test is a useful short-term human skin irritation test with high reproducibility....

  15. Reproducibility of scoring emphysema by HRCT

    Energy Technology Data Exchange (ETDEWEB)

    Malinen, A.; Partanen, K.; Rytkoenen, H.; Vanninen, R. [Kuopio Univ. Hospital (Finland). Dept. of Clinical Radiology; Erkinjuntti-Pekkanen, R. [Kuopio Univ. Hospital (Finland). Dept. of Pulmonary Diseases

    2002-04-01

    Purpose: We evaluated the reproducibility of three visual scoring methods of emphysema and compared these methods with pulmonary function tests (VC, DLCO, FEV1 and FEV%) among farmer's lung patients and farmers. Material and Methods: Three radiologists examined high-resolution CT images of farmer's lung patients and their matched controls (n=70) for chronic interstitial lung diseases. Intraobserver reproducibility and interobserver variability were assessed for three methods: severity, Sanders' (extent) and Sakai. Pulmonary function tests as spirometry and diffusing capacity were measured. Results: Intraobserver -values for all three methods were good (0.51-0.74). Interobserver varied from 0.35 to 0.72. The Sanders' and the severity methods correlated strongly with pulmonary function tests, especially DLCO and FEV1. Conclusion: The Sanders' method proved to be reliable in evaluating emphysema, in terms of good consistency of interpretation and good correlation with pulmonary function tests.

  16. Reproducibility of scoring emphysema by HRCT

    International Nuclear Information System (INIS)

    Malinen, A.; Partanen, K.; Rytkoenen, H.; Vanninen, R.; Erkinjuntti-Pekkanen, R.

    2002-01-01

    Purpose: We evaluated the reproducibility of three visual scoring methods of emphysema and compared these methods with pulmonary function tests (VC, DLCO, FEV1 and FEV%) among farmer's lung patients and farmers. Material and Methods: Three radiologists examined high-resolution CT images of farmer's lung patients and their matched controls (n=70) for chronic interstitial lung diseases. Intraobserver reproducibility and interobserver variability were assessed for three methods: severity, Sanders' (extent) and Sakai. Pulmonary function tests as spirometry and diffusing capacity were measured. Results: Intraobserver -values for all three methods were good (0.51-0.74). Interobserver varied from 0.35 to 0.72. The Sanders' and the severity methods correlated strongly with pulmonary function tests, especially DLCO and FEV1. Conclusion: The Sanders' method proved to be reliable in evaluating emphysema, in terms of good consistency of interpretation and good correlation with pulmonary function tests

  17. Additive Manufacturing: Reproducibility of Metallic Parts

    Directory of Open Access Journals (Sweden)

    Konda Gokuldoss Prashanth

    2017-02-01

    Full Text Available The present study deals with the properties of five different metals/alloys (Al-12Si, Cu-10Sn and 316L—face centered cubic structure, CoCrMo and commercially pure Ti (CP-Ti—hexagonal closed packed structure fabricated by selective laser melting. The room temperature tensile properties of Al-12Si samples show good consistency in results within the experimental errors. Similar reproducible results were observed for sliding wear and corrosion experiments. The other metal/alloy systems also show repeatable tensile properties, with the tensile curves overlapping until the yield point. The curves may then follow the same path or show a marginal deviation (~10 MPa until they reach the ultimate tensile strength and a negligible difference in ductility levels (of ~0.3% is observed between the samples. The results show that selective laser melting is a reliable fabrication method to produce metallic materials with consistent and reproducible properties.

  18. The Four-Tier Continuum of Academic and Behavioral Support (4T-CABS) Model: An Integrated Model for Medical Student Success.

    Science.gov (United States)

    Stegers-Jager, Karen M; Cohen-Schotanus, Janke; Themmen, Axel P N

    2017-11-01

    Not all students cope successfully with the demands of medical school, and students' struggles may result in study delay or dropout. To prevent these outcomes, medical schools need to identify students who are experiencing academic difficul ties and provide them with timely interventions through access to support programs. Although the importance of early identification and intervention is well recognized, less is known about successful strategies for identifying and supporting struggling students.Building on the literature and their own empirical findings, the authors propose an integrated, school-wide model for medical student success comprising a continuum of academic and behavioral support. This Four-Tier Continuum of Academic and Behavioral Support (4T-CABS) model focuses on improving both academic and behavioral outcomes by offering support for students at four levels, which range from adequate instruction for all, to targeted small-group interventions, to individualized support, and also include exit support for students who might be better off in another degree program. Additionally, medical schools should provide both academic and behavioral support; set high, yet realistic expectations and clearly communicate these to students; and intervene early, which requires timely identification of at-risk students who would benefit from the different types and tiers of support. Finally, interventions should be evidence based and fit the needs of the identified groups of students. The authors argue that adopting the core principles of the 4T-CABS model will enable medical schools to maximize academic engagement and performance for all students.

  19. Reproducibility of 201Tl myocardial imaging

    International Nuclear Information System (INIS)

    McLaughlin, P.R.; Martin, R.P.; Doherty, P.; Daspit, S.; Goris, M.; Haskell, W.; Lewis, S.; Kriss, J.P.; Harrison, D.C.

    1977-01-01

    Seventy-six thallium-201 myocardial perfusion studies were performed on twenty-five patients to assess their reproducibility and the effect of varying the level of exercise on the results of imaging. Each patient had a thallium-201 study at rest. Fourteen patients had studies on two occasions at maximum exercise, and twelve patients had studies both at light and at maximum exercise. Of 70 segments in the 14 patients assessed on each of two maximum exercise tests, 64 (91 percent) were reproducible. Only 53 percent (16/30) of the ischemic defects present at maximum exercise were seen in the light exercise study in the 12 patients assessed at two levels of exercise. Correlation of perfusion defects with arteriographically proven significant coronary stenosis was good for the left anterior descending and right coronary arteries, but not as good for circumflex artery disease. Thallium-201 myocardial imaging at maximum exercise is reproducible within acceptable limits, but careful attention to exercise technique is essential for valid comparative studies

  20. A Framework for Reproducible Latent Fingerprint Enhancements.

    Science.gov (United States)

    Carasso, Alfred S

    2014-01-01

    Photoshop processing of latent fingerprints is the preferred methodology among law enforcement forensic experts, but that appproach is not fully reproducible and may lead to questionable enhancements. Alternative, independent, fully reproducible enhancements, using IDL Histogram Equalization and IDL Adaptive Histogram Equalization, can produce better-defined ridge structures, along with considerable background information. Applying a systematic slow motion smoothing procedure to such IDL enhancements, based on the rapid FFT solution of a Lévy stable fractional diffusion equation, can attenuate background detail while preserving ridge information. The resulting smoothed latent print enhancements are comparable to, but distinct from, forensic Photoshop images suitable for input into automated fingerprint identification systems, (AFIS). In addition, this progressive smoothing procedure can be reexamined by displaying the suite of progressively smoother IDL images. That suite can be stored, providing an audit trail that allows monitoring for possible loss of useful information, in transit to the user-selected optimal image. Such independent and fully reproducible enhancements provide a valuable frame of reference that may be helpful in informing, complementing, and possibly validating the forensic Photoshop methodology.

  1. Evaluation of land surface model simulations of evapotranspiration over a 12 year crop succession: impact of the soil hydraulic properties

    Science.gov (United States)

    Garrigues, S.; Olioso, A.; Calvet, J.-C.; Martin, E.; Lafont, S.; Moulin, S.; Chanzy, A.; Marloie, O.; Desfonds, V.; Bertrand, N.; Renard, D.

    2014-10-01

    Evapotranspiration has been recognized as one of the most uncertain term in the surface water balance simulated by land surface models. In this study, the SURFEX/ISBA-A-gs simulations of evapotranspiration are assessed at local scale over a 12 year Mediterranean crop succession. The model is evaluated in its standard implementation which relies on the use of the ISBA pedotransfer estimates of the soil properties. The originality of this work consists in explicitly representing the succession of crop cycles and inter-crop bare soil periods in the simulations and assessing its impact on the dynamic of simulated and measured evapotranspiration over a long period of time. The analysis focuses on key soil parameters which drive the simulation of evapotranspiration, namely the rooting depth, the soil moisture at saturation, the soil moisture at field capacity and the soil moisture at wilting point. The simulations achieved with the standard values of these parameters are compared to those achieved with the in situ values. The portability of the ISBA pedotransfer functions is evaluated over a typical Mediterranean crop site. Various in situ estimates of the soil parameters are considered and distinct parametrization strategies are tested to represent the evapotranspiration dynamic over the crop succession. This work shows that evapotranspiration mainly results from the soil evaporation when it is continuously simulated over a Mediterranean crop succession. The evapotranspiration simulated with the standard surface and soil parameters of the model is largely underestimated. The deficit in cumulative evapotranspiration amounts to 24% over 12 years. The bias in daily daytime evapotranspiration is -0.24 mm day-1. The ISBA pedotransfer estimates of the soil moisture at saturation and at wilting point are overestimated which explains most of the evapotranspiration underestimation. The overestimation of the soil moisture at wilting point causes the underestimation of

  2. Educational Attainment: Success to the Successful

    Science.gov (United States)

    Anthony, Peter; Gould, David; Smith, Gina

    2013-01-01

    Systems archetypes are patterns of structure found in systems that are helpful in understanding some of the dynamics within them. The intent of this study was to examine educational attainment data using the success-to-the-successful archetype as a model to see if it helps to explain the inequality observed in the data. Data covering 1990 to 2009…

  3. Fluctuation-Driven Neural Dynamics Reproduce Drosophila Locomotor Patterns.

    Directory of Open Access Journals (Sweden)

    Andrea Maesani

    2015-11-01

    Full Text Available The neural mechanisms determining the timing of even simple actions, such as when to walk or rest, are largely mysterious. One intriguing, but untested, hypothesis posits a role for ongoing activity fluctuations in neurons of central action selection circuits that drive animal behavior from moment to moment. To examine how fluctuating activity can contribute to action timing, we paired high-resolution measurements of freely walking Drosophila melanogaster with data-driven neural network modeling and dynamical systems analysis. We generated fluctuation-driven network models whose outputs-locomotor bouts-matched those measured from sensory-deprived Drosophila. From these models, we identified those that could also reproduce a second, unrelated dataset: the complex time-course of odor-evoked walking for genetically diverse Drosophila strains. Dynamical models that best reproduced both Drosophila basal and odor-evoked locomotor patterns exhibited specific characteristics. First, ongoing fluctuations were required. In a stochastic resonance-like manner, these fluctuations allowed neural activity to escape stable equilibria and to exceed a threshold for locomotion. Second, odor-induced shifts of equilibria in these models caused a depression in locomotor frequency following olfactory stimulation. Our models predict that activity fluctuations in action selection circuits cause behavioral output to more closely match sensory drive and may therefore enhance navigation in complex sensory environments. Together these data reveal how simple neural dynamics, when coupled with activity fluctuations, can give rise to complex patterns of animal behavior.

  4. An Evaluation of the Adjusted DeLone and McLean Model of Information Systems Success; the case of financial information system in Ferdowsi University of Mashhad

    OpenAIRE

    Mohammad Lagzian; Shamsoddin Nazemi; Fatemeh Dadmand

    2012-01-01

    Assessing the success of information systems within organizations has been identified as one of the most critical subjects of information system management in both public and private organizations. It is therefore important to measure the success of information systems from the user's perspective. The purpose of the current study was to evaluate the degree of information system success by the adjusted DeLone and McLean’s model in the field financial information system (FIS) in an Iranian Univ...

  5. Comparison of different doses of epinephrine on myocardial perfusion and resuscitation success during cardiopulmonary resuscitation in a pig model.

    Science.gov (United States)

    Lindner, K H; Ahnefeld, F W; Bowdler, I M

    1991-01-01

    Published results of dose-response effects of adrenergic drugs (epinephrine [E]) vary so much between studies because of differences in animal models and duration of ischemia before drug administration. In this investigation the effects of different doses of E on coronary perfusion pressure (CPP), left ventricular myocardial blood flow (MBF) and resuscitation success were compared during closed-chest cardiopulmonary resuscitation (CPR) after a 4-minute period of ventricular fibrillation in 28 pigs. MBF was measured during normal sinus rhythm using tracer microspheres. After 4 minutes of ventricular fibrillation CPR was performed with the use of a pneumatic piston compressor. After 4 minutes of mechanical measures only, the animals were randomly allocated into four groups of seven, receiving 0.015, 0.030, 0.045, and 0.090 mg/kg E intravenously respectively. MBF measurements were started 45 seconds after E administration; hemodynamic measurements after 90 seconds. Four minutes after the first administration, the same E dose was given before defibrillation. The CPP of animals given 0.015, 0.030, 0.045 and 0.090 mg/kg E were as follows: 16.3 +/- 6.1, 25.6 +/- 5.8, 33.2 +/- 8.4 and 30.4 +/- 6.3 mm Hg. The left ventricular MBF values were: 14 +/- 9, 27 +/- 11, 43 +/- 6, 46 +/- 10 mL/min/100 g. The differences between the groups receiving 0.015 and 0.045 mg/kg and between the groups receiving 0.015 mg/kg and 0.090 mg/kg were statistically significant (P less than .05). Resuscitation success was 14.3%, 42.9%, 100% and 86.7% respectively. A significant difference in resuscitation success was found only between 0.015 mg/kg and 0.045 mg/kg E.(ABSTRACT TRUNCATED AT 250 WORDS)

  6. The Effects of Transformational Leadership and Mediating Factors on the Organizational Success Using Structural Equation Modeling: A Case Study.

    Science.gov (United States)

    Ravangard, Ramin; Karimi, Sakine; Farhadi, Payam; Sajjadnia, Zahra; Shokrpour, Nasrin

    This study was undertaken to determine the effects of transformational leadership (TL) and mediating factors on organizational success (OS) from the administrative, financial, and support employees' perspective in teaching hospitals affiliated with Shiraz University of Medical Sciences using structural equation modeling. Three hundred administrative and financial employees were selected, using stratified sampling proportional to size and simple random sampling. Data were collected using 5 questionnaires and analyzed using SPSS 21.0 and Lisrel 8.5 through Pearson correlation coefficient and path analysis and confirmatory factor analysis methods. Results showed that TL had significant positive effects on the 3 mediating factors, including organizational culture (t = 15.31), organizational citizenship behavior (OCB) (t = 10.06), and social capital (t = 10.25). Also, the organizational culture (t = 2.26), OCB (t = 3.48), and social capital (t = 7.41) had significant positive effects on OS. According to the results, TL had an indirect effect on OS. Therefore, organizations can achieve more success by strengthening organizational culture, OCB, and social capital through using transformational leadership style. Therefore, in order to increase OS, the following recommendations are made: supporting and encouraging new ideas in the organization, promoting teamwork, strengthening intergroup and intragroup relationships, planning to strengthen and enrich the social and organizational culture, considering the promotion of social capital in the employee training, establishing a system to give rewards to the employees performing extra-role activities, providing a suitable environment for creative employees, and so on.

  7. Effective Strategies for District Leadership to Create Successful Inclusion Models: Special Education Directors and School Reform in Context of Least Restrictive Environment

    Science.gov (United States)

    Bublitz, Gregory

    2016-01-01

    This qualitative mixed methods study explored how Special Education Directors transformed and maintained a successful inclusion model throughout their district. The study identified leadership strategies and inclusive behaviors utilized by Special Education Directors who have successfully transformed their district into inclusive school districts.…

  8. Design and Simulation of a 6-Bit Successive-Approximation ADC Using Modeled Organic Thin-Film Transistors

    Directory of Open Access Journals (Sweden)

    Huyen Thanh Pham

    2016-01-01

    Full Text Available We have demonstrated a method for using proper models of pentacene P-channel and fullerene N-channel thin-film transistors (TFTs in order to design and simulate organic integrated circuits. Initially, the transistors were fabricated, and we measured their main physical and electrical parameters. Then, these organic TFTs (OTFTs were modeled with support of an organic process design kit (OPDK added in Cadence. The key specifications of the modeled elements were extracted from measured data, whereas the fitting ones were elected to replicate experimental curves. The simulating process proves that frequency responses of the TFTs cover all biosignal frequency ranges; hence, it is reasonable to deploy the elements to design integrated circuits used in biomedical applications. Complying with complementary rules, the organic circuits work properly, including logic gates, flip-flops, comparators, and analog-to-digital converters (ADCs as well. The proposed successive-approximation-register (SAR ADC consumes a power of 883.7 µW and achieves an ENOB of 5.05 bits, a SNR of 32.17 dB at a supply voltage of 10 V, and a sampling frequency of about 2 KHz.

  9. Automated Generation of Technical Documentation and Provenance for Reproducible Research

    Science.gov (United States)

    Jolly, B.; Medyckyj-Scott, D.; Spiekermann, R.; Ausseil, A. G.

    2017-12-01

    Data provenance and detailed technical documentation are essential components of high-quality reproducible research, however are often only partially addressed during a research project. Recording and maintaining this information during the course of a project can be a difficult task to get right as it is a time consuming and often boring process for the researchers involved. As a result, provenance records and technical documentation provided alongside research results can be incomplete or may not be completely consistent with the actual processes followed. While providing access to the data and code used by the original researchers goes some way toward enabling reproducibility, this does not count as, or replace, data provenance. Additionally, this can be a poor substitute for good technical documentation and is often more difficult for a third-party to understand - particularly if they do not understand the programming language(s) used. We present and discuss a tool built from the ground up for the production of well-documented and reproducible spatial datasets that are created by applying a series of classification rules to a number of input layers. The internal model of the classification rules required by the tool to process the input data is exploited to also produce technical documentation and provenance records with minimal additional user input. Available provenance records that accompany input datasets are incorporated into those that describe the current process. As a result, each time a new iteration of the analysis is performed the documentation and provenance records are re-generated to provide an accurate description of the exact process followed. The generic nature of this tool, and the lessons learned during its creation, have wider application to other fields where the production of derivative datasets must be done in an open, defensible, and reproducible way.

  10. Telehealth services in rural and remote Australia: a systematic review of models of care and factors influencing success and sustainability.

    Science.gov (United States)

    Bradford, Natalie K; Caffery, Liam J; Smith, Anthony C

    2016-01-01

    including clinical speciality, disciplines involved, geographical location and the role of the service. Data relating to the success or sustainability of services were grouped thematically. Inclusion criteria were met by 116 articles that described 72 discrete telehealth services. Telehealth services in rural and remote Australia are described and we have identified six key factors associated with the success and sustainability of services: vision, ownership, adaptability, economics, efficiency and equipment. Telehealth has the potential to address many of the key challenges to providing health in Australia, with its substantial land area and widely dispersed population. This review collates information regarding the telehealth services in Australia and describes models of care and characteristics of successful and sustainable services. We identified a wide variety of telehealth services being provided in rural and remote areas of Australia. There is great potential to increase this number by scaling up and replicating successful services. This review provides information for policy makers, governments and public and private health services that wish to integrate telehealth into routine practice and for telehealth providers to enhance the sustainability of their service.

  11. The value of applying a melatonin antagonist (Luzindole) in improving the success rate of the bipedal rat scoliosis model.

    Science.gov (United States)

    Yang, Shuo; Zheng, Chaojun; Jiang, Jianyuan; Lu, Feizhou; Xia, Xinlei; Zhu, Wei; Jin, Xiang; Ma, Xiaosheng

    2017-04-04

    An ideal animal model has always been the key to research the pathogenesis and treatment of adolescent idiopathic scoliosis (AIS), while available methods have obvious disadvantages. The deficiency of melatonin has been proved relating to AIS. In this research, we intended to apply Luzindole, the melatonin antagonist, in bipedal rat model, for the block of combination of melatonin and its receptor, to inhibit the melatonin effect, and then to understand whether this method can effectively improve the scoliosis rate of bipedal rat model, and investigate the role of melatonin in scoliosis. To investigate the feasibility of improving the success rate of bipedal rat scoliosis model via intraperitoneal injection of melatonin antagonist (Luzindole). A total of 60 3-weeks-old Sprague-Dawley rats were included in this study, and were divided into 3 groups (A, B and C). Each group included 20 rats. Osteotomy of the bilateral proximal humerus and proximal tailbone was performed in group A and group B; intraperitoneal injection of Luzindole (0.2 mg/kg) was performed in group A and group C. X-rays were taken before the surgery, 1 month after the surgery, 3 months after the surgery, and 6 months after the surgery, to calculate the Cobb's angle of the spine (>10° was considered scoliosis). The weight of every rat was also measured at the same time. Rats were euthanized 6 months after surgery to determine the calmodulin level in thrombocytes. The rate of scoliosis in group A (14/20) was significantly higher than those in group B (6/20) and group C (0/20) (P scoliosis model. Meanwhile, this study indicates that a decreased melatonin level is not the primary cause of scoliosis, but that it may increase the likelihood and severity of scoliosis.

  12. Open and reproducible global land use classification

    Science.gov (United States)

    Nüst, Daniel; Václavík, Tomáš; Pross, Benjamin

    2015-04-01

    Researchers led by the Helmholtz Centre for Environmental research (UFZ) developed a new world map of land use systems based on over 30 diverse indicators (http://geoportal.glues.geo.tu-dresden.de/stories/landsystemarchetypes.html) of land use intensity, climate and environmental and socioeconomic factors. They identified twelve land system archetypes (LSA) using a data-driven classification algorithm (self-organizing maps) to assess global impacts of land use on the environment, and found unexpected similarities across global regions. We present how the algorithm behind this analysis can be published as an executable web process using 52°North WPS4R (https://wiki.52north.org/bin/view/Geostatistics/WPS4R) within the GLUES project (http://modul-a.nachhaltiges-landmanagement.de/en/scientific-coordination-glues/). WPS4R is an open source collaboration platform for researchers, analysts and software developers to publish R scripts (http://www.r-project.org/) as a geo-enabled OGC Web Processing Service (WPS) process. The interoperable interface to call the geoprocess allows both reproducibility of the analysis and integration of user data without knowledge about web services or classification algorithms. The open platform allows everybody to replicate the analysis in their own environments. The LSA WPS process has several input parameters, which can be changed via a simple web interface. The input parameters are used to configure both the WPS environment and the LSA algorithm itself. The encapsulation as a web process allows integration of non-public datasets, while at the same time the publication requires a well-defined documentation of the analysis. We demonstrate this platform specifically to domain scientists and show how reproducibility and open source publication of analyses can be enhanced. We also discuss future extensions of the reproducible land use classification, such as the possibility for users to enter their own areas of interest to the system and

  13. Queer nuclear families? Reproducing and transgressing heteronormativity.

    Science.gov (United States)

    Folgerø, Tor

    2008-01-01

    During the past decade the public debate on gay and lesbian adoptive rights has been extensive in the Norwegian media. The debate illustrates how women and men planning to raise children in homosexual family constellations challenge prevailing cultural norms and existing concepts of kinship and family. The article discusses how lesbian mothers and gay fathers understand and redefine their own family practices. An essential point in this article is the fundamental ambiguity in these families' accounts of themselves-how they simultaneously transgress and reproduce heteronormative assumptions about childhood, fatherhood, motherhood, family and kinship.

  14. Long-term success and failure with SG is predictable by 3 months: a multivariate model using simple office markers.

    Science.gov (United States)

    Cottam, Austin; Billing, Josiah; Cottam, Daniel; Billing, Peter; Cottam, Samuel; Zaveri, Hinali; Surve, Amit

    2017-08-01

    Despite being the most common surgery in the United States, little is known about predicting weight loss success and failure with sleeve gastrectomy (SG). Papers that have been published are inconclusive. We decided to use multivariate analysis from 2 practices to design a model to predict weight loss outcomes using data widely available to any surgical practice at 3 months to determine weight loss outcomes at 1 year. Two private practices in the United States. A retrospective review of 613 patients from 2 bariatric institutions were included in this study. Co-morbidities and other preoperative characteristics were gathered, and %EWL was calculated for 1, 3, and 12 months. Excess weight loss (%EWL)failure. Multiple variate analysis was used to find factors that affect %EWL at 12 months. Preoperative sleep apnea, preoperative diabetes, %EWL at 1 month, and %EWL at 3 months all affect %EWL at 1 year. The positive predictive value and negative predictive value of our model was 72% and 91%, respectively. Sensitivity and specificity were 71% and 91%, respectively. One-year results of the SG can be predicted by diabetes, sleep apnea, and weight loss velocity at 3 months postoperatively. This can help surgeons direct surgical or medical interventions for patients at 3 months rather than at 1 year or beyond. Copyright © 2017 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

  15. Efficient and reproducible identification of mismatch repair deficient colon cancer

    DEFF Research Database (Denmark)

    Joost, Patrick; Bendahl, Pär-Ola; Halvarsson, Britta

    2013-01-01

    BACKGROUND: The identification of mismatch-repair (MMR) defective colon cancer is clinically relevant for diagnostic, prognostic and potentially also for treatment predictive purposes. Preselection of tumors for MMR analysis can be obtained with predictive models, which need to demonstrate ease...... of application and favorable reproducibility. METHODS: We validated the MMR index for the identification of prognostically favorable MMR deficient colon cancers and compared performance to 5 other prediction models. In total, 474 colon cancers diagnosed ≥ age 50 were evaluated with correlation between...... and efficiently identifies MMR defective colon cancers with high sensitivity and specificity. The model shows stable performance with low inter-observer variability and favorable performance when compared to other MMR predictive models....

  16. Timbral aspects of reproduced sound in small rooms. I

    DEFF Research Database (Denmark)

    Bech, Søren

    1995-01-01

    This paper reports some of the influences of individual reflections on the timbre of reproduced sound. A single loudspeaker with frequency-independent directivity characteristics, positioned in a listening room of normal size with frequency-independent absorption coefficients of the room surfaces......, has been simulated using an electroacoustic setup. The model included the direct sound, 17 individual reflections, and the reverberant field. The threshold of detection and just-noticeable differences for an increase in level were measured for individual reflections using eight subjects for noise...

  17. Reproducibility of studies on text mining for citation screening in systematic reviews: Evaluation and checklist.

    Science.gov (United States)

    Olorisade, Babatunde Kazeem; Brereton, Pearl; Andras, Peter

    2017-09-01

    Independent validation of published scientific results through study replication is a pre-condition for accepting the validity of such results. In computation research, full replication is often unrealistic for independent results validation, therefore, study reproduction has been justified as the minimum acceptable standard to evaluate the validity of scientific claims. The application of text mining techniques to citation screening in the context of systematic literature reviews is a relatively young and growing computational field with high relevance for software engineering, medical research and other fields. However, there is little work so far on reproduction studies in the field. In this paper, we investigate the reproducibility of studies in this area based on information contained in published articles and we propose reporting guidelines that could improve reproducibility. The study was approached in two ways. Initially we attempted to reproduce results from six studies, which were based on the same raw dataset. Then, based on this experience, we identified steps considered essential to successful reproduction of text mining experiments and characterized them to measure how reproducible is a study given the information provided on these steps. 33 articles were systematically assessed for reproducibility using this approach. Our work revealed that it is currently difficult if not impossible to independently reproduce the results published in any of the studies investigated. The lack of information about the datasets used limits reproducibility of about 80% of the studies assessed. Also, information about the machine learning algorithms is inadequate in about 27% of the papers. On the plus side, the third party software tools used are mostly free and available. The reproducibility potential of most of the studies can be significantly improved if more attention is paid to information provided on the datasets used, how they were partitioned and utilized, and

  18. Success rate evaluation of clinical governance implementation in teaching hospitals in Kerman (Iran) based on nine steps of Karsh's model.

    Science.gov (United States)

    Vali, Leila; Mastaneh, Zahra; Mouseli, Ali; Kardanmoghadam, Vida; Kamali, Sodabeh

    2017-07-01

    One of the ways to improve the quality of services in the health system is through clinical governance. This method aims to create a framework for clinical services providers to be accountable in return for continuing improvement of quality and maintaining standards of services. To evaluate the success rate of clinical governance implementation in Kerman teaching hospitals based on 9 steps of Karsh's Model. This cross-sectional study was conducted in 2015 on 94 people including chief executive officers (CEOs), nursing managers, clinical governance managers and experts, head nurses and nurses. The required data were collected through a researcher-made questionnaire containing 38 questions with three-point Likert Scale (good, moderate, and weak). The Karsh's Model consists of nine steps including top management commitment to change, accountability for change, creating a structured approach for change, training, pilot implementation, communication, feedback, simulation, and end-user participation. Data analysis using descriptive statistics and Mann-Whitney-Wilcoxon test was done by SPSS software version 16. About 81.9 % of respondents were female and 74.5 have a Bachelor of Nursing (BN) degree. In general, the status of clinical governance implementation in studied hospitals based on 9 steps of the model was 44 % (moderate). A significant relationship was observed among accountability and organizational position (p=0.0012) and field of study (p=0.000). Also, there were significant relationships between structure-based approach and organizational position (p=0.007), communication and demographic characteristics (p=0.000), and end-user participation with organizational position (p=0.03). Clinical governance should be implemented by correct needs assessment and participation of all stakeholders, to ensure its enforcement in practice, and to enhance the quality of services.

  19. Reproducibility of the interpretation of pelvic x-ray 3 months after hysteroscopic sterilization with Essure

    NARCIS (Netherlands)

    Veersema, Sebastiaan; Mol, Ben W. J.; Brölmann, Hans A. M.

    2010-01-01

    Objective: To estimate the diagnostic accuracy and the interobserver reproducibility of pelvic x-rays in the diagnosis of successful bilateral sterilization with Essure after a 3-month follow-up period. Design: Interobserver study. Setting: Outpatient department of obstetrics and gynecology in a

  20. Is Grannum grading of the placenta reproducible?

    Science.gov (United States)

    Moran, Mary; Ryan, John; Brennan, Patrick C.; Higgins, Mary; McAuliffe, Fionnuala M.

    2009-02-01

    Current ultrasound assessment of placental calcification relies on Grannum grading. The aim of this study was to assess if this method is reproducible by measuring inter- and intra-observer variation in grading placental images, under strictly controlled viewing conditions. Thirty placental images were acquired and digitally saved. Five experienced sonographers independently graded the images on two separate occasions. In order to eliminate any technological factors which could affect data reliability and consistency all observers reviewed images at the same time. To optimise viewing conditions ambient lighting was maintained between 25-40 lux, with monitors calibrated to the GSDF standard to ensure consistent brightness and contrast. Kappa (κ) analysis of the grades assigned was used to measure inter- and intra-observer reliability. Intra-observer agreement had a moderate mean κ-value of 0.55, with individual comparisons ranging from 0.30 to 0.86. Two images saved from the same patient, during the same scan, were each graded as I, II and III by the same observer. A mean κ-value of 0.30 (range from 0.13 to 0.55) indicated fair inter-observer agreement over the two occasions and only one image was graded consistently the same by all five observers. The study findings confirmed the lack of reproducibility associated with Grannum grading of the placenta despite optimal viewing conditions and highlight the need for new methods of assessing placental health in order to improve neonatal outcomes. Alternative methods for quantifying placental calcification such as a software based technique and 3D ultrasound assessment need to be explored.

  1. Analysis of Success Factors to Implement Sustainable Supply Chain Management Using Interpretive Structural Modeling Technique: A Real Case Perspective

    OpenAIRE

    Mengke Yang; Mahmood Movahedipour; Jianqiu Zeng; Zhou Xiaoguang; Ludi Wang

    2017-01-01

    Sustainability draws increased supply chain management (SCM) attention. This article analyzes critical success to the assessment, evaluation, and attainment of sustainable supply chain management (SSCM), assessed through critical-success identification and qualitative data analysis. Namely, a literature review selected of 188 articles, published between January 1994 and November 2016, helps identify the most influential success factors. The qualitative data analysis pertains to fifteen such s...

  2. The Coppin Academy for Pre-Nursing Success: a model for the recruitment and retention of minority students.

    Science.gov (United States)

    Gordon, Frances C; Copes, Marcella A

    2010-01-01

    There is a clearly documented need for greater minority representation in professional nursing as the nation grows more diversified. Increasing the ranks of minority nurses will assist both in alleviating the nursing shortage and in addressing the health care disparities that plague our healthcare systems. One barrier has been the recruitment and retention of underserved minority nursing students. To address this, the Coppin State University Helene Fuld School of Nursing (HFSON) in Baltimore, Maryland developed and implemented the "Coppin Academy for Pre-Nursing Success" (CAPS), a comprehensive year-round pre-entry baccalaureate preparation program, targeting high school students from disadvantaged backgrounds who are interested in a nursing career. CAPS graduates have met or exceeded goals in retention, passing rate on the nursing licensure exam, and service to the community. As a result, the program is growing, and the School plans to replicate the CAPS model, not only in surrounding communities, but in other vulnerable and under-served urban settings in the nation.

  3. Successful ageing

    DEFF Research Database (Denmark)

    Kusumastuti, Sasmita; Derks, Marloes G. M.; Tellier, Siri

    2016-01-01

    . METHODS: We performed a novel, hypothesis-free and quantitative analysis of citation networks exploring the literature on successful ageing that exists in the Web of Science Core Collection Database using the CitNetExplorer software. Outcomes were visualized using timeline-based citation patterns...... himself or an outsider judges the situation. These different points of view help to explain the disability paradox, as successful ageing lies in the eyes of the beholder....

  4. Evaluation of Statistical Downscaling Skill at Reproducing Extreme Events

    Science.gov (United States)

    McGinnis, S. A.; Tye, M. R.; Nychka, D. W.; Mearns, L. O.

    2015-12-01

    Climate model outputs usually have much coarser spatial resolution than is needed by impacts models. Although higher resolution can be achieved using regional climate models for dynamical downscaling, further downscaling is often required. The final resolution gap is often closed with a combination of spatial interpolation and bias correction, which constitutes a form of statistical downscaling. We use this technique to downscale regional climate model data and evaluate its skill in reproducing extreme events. We downscale output from the North American Regional Climate Change Assessment Program (NARCCAP) dataset from its native 50-km spatial resolution to the 4-km resolution of University of Idaho's METDATA gridded surface meterological dataset, which derives from the PRISM and NLDAS-2 observational datasets. We operate on the major variables used in impacts analysis at a daily timescale: daily minimum and maximum temperature, precipitation, humidity, pressure, solar radiation, and winds. To interpolate the data, we use the patch recovery method from the Earth System Modeling Framework (ESMF) regridding package. We then bias correct the data using Kernel Density Distribution Mapping (KDDM), which has been shown to exhibit superior overall performance across multiple metrics. Finally, we evaluate the skill of this technique in reproducing extreme events by comparing raw and downscaled output with meterological station data in different bioclimatic regions according to the the skill scores defined by Perkins et al in 2013 for evaluation of AR4 climate models. We also investigate techniques for improving bias correction of values in the tails of the distributions. These techniques include binned kernel density estimation, logspline kernel density estimation, and transfer functions constructed by fitting the tails with a generalized pareto distribution.

  5. Response to Comment on "Estimating the reproducibility of psychological science"

    NARCIS (Netherlands)

    Anderson, Christopher J; Bahník, Štěpán; Barnett-Cowan, Michael; Bosco, Frank A; Chandler, Jesse; Chartier, Christopher R; Cheung, Felix; Christopherson, Cody D; Cordes, Andreas; Cremata, Edward J; Della Penna, Nicolas; Estel, Vivien; Fedor, Anna; Fitneva, Stanka A; Frank, Michael C; Grange, James A; Hartshorne, Joshua K; Hasselman, Fred; Henninger, Felix; van der Hulst, Marije; Jonas, Kai J; Lai, Calvin K; Levitan, Carmel A; Miller, Jeremy K; Moore, Katherine S; Meixner, Johannes M; Munafò, Marcus R; Neijenhuijs, Koen I; Nilsonne, Gustav; Nosek, Brian A; Plessow, Franziska; Prenoveau, Jason M; Ricker, Ashley A; Schmidt, Kathleen; Spies, Jeffrey R; Stieger, Stefan; Strohminger, Nina; Sullivan, Gavin B; van Aert, Robbie C M; van Assen, Marcel A L M; Vanpaemel, Wolf; Vianello, Michelangelo; Voracek, Martin; Zuni, Kellylynn

    2016-01-01

    Gilbert et al. conclude that evidence from the Open Science Collaboration's Reproducibility Project: Psychology indicates high reproducibility, given the study methodology. Their very optimistic assessment is limited by statistical misconceptions and by causal inferences from selectively

  6. Doing the right thing! A model for building a successful hospital-based ethics committee in Nunavut

    Directory of Open Access Journals (Sweden)

    Madeleine Cole

    2013-08-01

    Full Text Available Background. There exists a need throughout the North to increase capacity to address issues of health ethics and for community members to better understand and share their perspectives on this topic. Ethics comes down to weighing rights and wrongs, evaluating differing needs and understandings, acknowledging the many shades of grey and doing our best to come up with the just, fair and moral approach to the question at hand. Northern regions must collaborate to share capacity, successes and experiences in order to meet the unique needs of northern health care institutions and move forward on this issue. While guidelines for ethical research with indigenous populations exist, little has been published about an Inuit approach to health ethics more broadly. Design . To fill a critical need and to meet accreditation standards, the Qikiqtani General Hospital (QGH in Iqaluit, Nunavut, Canada, is in the process of building an Ethics Committee. Capitalizing on partnerships with other bodies both in northern and southern Canada has proved an efficient and effective way to develop local solutions to challenges that have been experienced both at QGH and other jurisdictions. Methods . The Ottawa Hospital Ethics Office and the active ethics committee at Stanton General Hospital in Yellowknife, NT, contributed expertise and experience, and helped provide some direction for the QGH ethics committee. At the local level, based on our shared commitment to health care ethics, the Qaujigiartiit Health Research Centre is an invaluable partner whose parallel efforts to develop a northern Health Research Ethics Board (REB gives great synergy to the QGH Ethics Committee. Results . Passion and commitment, as well as administrative support and endorsement from health care leaders, are the aspects of successful initiatives that we have identified to date. Using the information from both the experiences of other partners, as well as information gathered at a retreat held in

  7. Doing the right thing! A model for building a successful hospital-based ethics committee in Nunavut.

    Science.gov (United States)

    Cole, Madeleine; Healey, Gwen

    2013-01-01

    There exists a need throughout the North to increase capacity to address issues of health ethics and for community members to better understand and share their perspectives on this topic. Ethics comes down to weighing rights and wrongs, evaluating differing needs and understandings, acknowledging the many shades of grey and doing our best to come up with the just, fair and moral approach to the question at hand. Northern regions must collaborate to share capacity, successes and experiences in order to meet the unique needs of northern health care institutions and move forward on this issue. While guidelines for ethical research with indigenous populations exist, little has been published about an Inuit approach to health ethics more broadly. To fill a critical need and to meet accreditation standards, the Qikiqtani General Hospital (QGH) in Iqaluit, Nunavut, Canada, is in the process of building an Ethics Committee. Capitalizing on partnerships with other bodies both in northern and southern Canada has proved an efficient and effective way to develop local solutions to challenges that have been experienced both at QGH and other jurisdictions. The Ottawa Hospital Ethics Office and the active ethics committee at Stanton General Hospital in Yellowknife, NT, contributed expertise and experience, and helped provide some direction for the QGH ethics committee. At the local level, based on our shared commitment to health care ethics, the Qaujigiartiit Health Research Centre is an invaluable partner whose parallel efforts to develop a northern Health Research Ethics Board (REB) gives great synergy to the QGH Ethics Committee. Passion and commitment, as well as administrative support and endorsement from health care leaders, are the aspects of successful initiatives that we have identified to date. Using the information from both the experiences of other partners, as well as information gathered at a retreat held in Iqaluit in September 2011, we are working to develop a

  8. Stimulating seedling growth in early stages of secondary forest succession: a modeling approach to guide tree liberation

    NARCIS (Netherlands)

    Kuijk, M.; Anten, N.P.R.; Oomen, R.J.; Schieving, F.

    2014-01-01

    Excessive growth of non-woody plants and shrubs on degraded lands can strongly hamper tree growth and thus secondary forest succession. A common method to accelerate succession, called liberation, involves opening up the vegetation canopy around young target trees. This can increase growth of target

  9. Stimulating seedling growth in early stages of secondary forest succession : a modeling approach to guide tree liberation

    NARCIS (Netherlands)

    van Kuijk, Marijke; Anten, Niels P. R.; Oomen, Roelof J.; Schieving, Feike

    2014-01-01

    Excessive growth of non-woody plants and shrubs on degraded lands can strongly hamper tree growth and thus secondary forest succession. A common method to accelerate succession, called liberation, involves opening up the vegetation canopy around young target trees. This can increase growth of target

  10. Testing a Model of Environmental Risk and Protective Factors to Predict Middle and High School Students' Academic Success

    Science.gov (United States)

    Peters, S. Colby; Woolley, Michael E.

    2015-01-01

    Data from the School Success Profile generated by 19,228 middle and high school students were organized into three broad categories of risk and protective factors--control, support, and challenge--to examine the relative and combined power of aggregate scale scores in each category so as to predict academic success. It was hypothesized that higher…

  11. Successful ageing

    DEFF Research Database (Denmark)

    Bülow, Morten Hillgaard; Söderqvist, Thomas

    2014-01-01

    Since the late 1980s, the concept of ‘ successful ageing’ has set the frame for discourse about contemporary ageing research. Through an analysis of the reception to John W. Rowe and Robert L. Kahn's launch of the concept of ‘ successful ageing’ in 1987, this article maps out the important themes...... strategies; and the importance of individual, societal and scientific conceptualisations and understandings of ageing. By presenting an account of the recent historical uses, interpretations and critiques of the concept, the article unfolds the practical and normative complexities of ‘ successful ageing’....... and discussions that have emerged from the interdisciplinary field of ageing research. These include an emphasis on interdisciplinarity; the interaction between biology, psycho-social contexts and lifestyle choices; the experiences of elderly people; life-course perspectives; optimisation and prevention...

  12. Citation Success

    DEFF Research Database (Denmark)

    Vaio, Gianfranco Di; Waldenström, Daniel; Weisdorf, Jacob Louis

    2012-01-01

    This study examines the determinants of citation success among authors who have recently published their work in economic history journals. Besides offering clues about how to improve one's scientific impact, our citation analysis also sheds light on the state of the field of economic history....... Consistent with our expectations, we find that full professors, authors appointed at economics and history departments, and authors working in Anglo-Saxon and German countries are more likely to receive citations than other scholars. Long and co-authored articles are also a factor for citation success. We...... find similar patterns when assessing the same authors' citation success in economics journals. As a novel feature, we demonstrate that the diffusion of research — publication of working papers, as well as conference and workshop presentations — has a first-order positive impact on the citation rate....

  13. Reliability: on the reproducibility of assessment data.

    Science.gov (United States)

    Downing, Steven M

    2004-09-01

    All assessment data, like other scientific experimental data, must be reproducible in order to be meaningfully interpreted. The purpose of this paper is to discuss applications of reliability to the most common assessment methods in medical education. Typical methods of estimating reliability are discussed intuitively and non-mathematically. Reliability refers to the consistency of assessment outcomes. The exact type of consistency of greatest interest depends on the type of assessment, its purpose and the consequential use of the data. Written tests of cognitive achievement look to internal test consistency, using estimation methods derived from the test-retest design. Rater-based assessment data, such as ratings of clinical performance on the wards, require interrater consistency or agreement. Objective structured clinical examinations, simulated patient examinations and other performance-type assessments generally require generalisability theory analysis to account for various sources of measurement error in complex designs and to estimate the consistency of the generalisations to a universe or domain of skills. Reliability is a major source of validity evidence for assessments. Low reliability indicates that large variations in scores can be expected upon retesting. Inconsistent assessment scores are difficult or impossible to interpret meaningfully and thus reduce validity evidence. Reliability coefficients allow the quantification and estimation of the random errors of measurement in assessments, such that overall assessment can be improved.

  14. Environment and industrial economy: Challenge of reproducibility

    International Nuclear Information System (INIS)

    Rullani, E.

    1992-01-01

    Historically and methodologically counterposed until now, the environmentalist and the economic approach to environmental problems need to be integrated in a new approach that considers, from one side, the relevance of the ecological equilibria for the economic systems and, from the other side, the economic dimension (in terms of investments and transformations in the production system) of any attempt to achieve a better environment. In order to achieve this integration, both approaches are compelled to give up some cultural habits that have characterized them, and have contributed to over-emphasize the opposition between them. The article shows that both approaches can converge into a new one, in which environment is no longer only an holistic, not bargainable, natural external limit to human activity (as in the environmentalist approach), nor simply a scarce and exhaustible resource (as economics tends to consider it); environment should instead become part of the reproducibility sphere, or, in other words, it must be regarded as part of the output that the economic system provides. This new approach, due to scientific and technological advances, is made possible for an increasing class of environmental problems. In order to do this, an evolution is required, that could be able to convert environmental goals into investment and technological innovation goals, and communicate to the firms the value society assigns to environmental resources. This value, the author suggests, should correspond to the reproduction cost. Various examples of this new approach are analyzed and discussed

  15. Reproducibility of neuroimaging analyses across operating systems.

    Science.gov (United States)

    Glatard, Tristan; Lewis, Lindsay B; Ferreira da Silva, Rafael; Adalat, Reza; Beck, Natacha; Lepage, Claude; Rioux, Pierre; Rousseau, Marc-Etienne; Sherif, Tarek; Deelman, Ewa; Khalili-Mahani, Najmeh; Evans, Alan C

    2015-01-01

    Neuroimaging pipelines are known to generate different results depending on the computing platform where they are compiled and executed. We quantify these differences for brain tissue classification, fMRI analysis, and cortical thickness (CT) extraction, using three of the main neuroimaging packages (FSL, Freesurfer and CIVET) and different versions of GNU/Linux. We also identify some causes of these differences using library and system call interception. We find that these packages use mathematical functions based on single-precision floating-point arithmetic whose implementations in operating systems continue to evolve. While these differences have little or no impact on simple analysis pipelines such as brain extraction and cortical tissue classification, their accumulation creates important differences in longer pipelines such as subcortical tissue classification, fMRI analysis, and cortical thickness extraction. With FSL, most Dice coefficients between subcortical classifications obtained on different operating systems remain above 0.9, but values as low as 0.59 are observed. Independent component analyses (ICA) of fMRI data differ between operating systems in one third of the tested subjects, due to differences in motion correction. With Freesurfer and CIVET, in some brain regions we find an effect of build or operating system on cortical thickness. A first step to correct these reproducibility issues would be to use more precise representations of floating-point numbers in the critical sections of the pipelines. The numerical stability of pipelines should also be reviewed.

  16. Reproducibility of the water drinking test.

    Science.gov (United States)

    Muñoz, C R; Macias, J H; Hartleben, C

    2015-11-01

    To investigate the reproducibility of the water drinking test in determining intraocular pressure peaks and fluctuation. It has been suggested that there is limited agreement between the water drinking test and diurnal tension curve. This may be because it has only been compared with a 10-hour modified diurnal tension curve, missing 70% of IOP peaks that occurred during night. This was a prospective, analytical and comparative study that assesses the correlation, agreement, sensitivity and specificity of the water drinking test. The correlation between the water drinking test and diurnal tension curve was significant and strong (r=0.93, Confidence interval 95% between 0.79 and 0.96, p<01). A moderate agreement was observed between these measurements (pc=0.93, Confidence interval 95% between 0.87 and 0.95, p<.01). The agreement was within±2mmHg in 89% of the tests. Our study found a moderate agreement between the water drinking test and diurnal tension curve, in contrast with the poor agreement found in other studies, possibly due to the absence of nocturnal IOP peaks. These findings suggest that the water drinking test could be used to determine IOP peaks, as well as for determining baseline IOP. Copyright © 2014 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

  17. Are classifications of proximal radius fractures reproducible?

    Directory of Open Access Journals (Sweden)

    dos Santos João BG

    2009-10-01

    Full Text Available Abstract Background Fractures of the proximal radius need to be classified in an appropriate and reproducible manner. The aim of this study was to assess the reliability of the three most widely used classification systems. Methods Elbow radiographs images of patients with proximal radius fractures were classified according to Mason, Morrey, and Arbeitsgemeinschaft für osteosynthesefragen/Association for the Study of Internal Fixation (AO/ASIF classifications by four observers with different experience with this subject to assess their intra- and inter-observer agreement. Each observer analyzed the images on three different occasions on a computer with numerical sequence randomly altered. Results We found that intra-observer agreement of Mason and Morrey classifications were satisfactory (κ = 0.582 and 0.554, respectively, while the AO/ASIF classification had poor intra-observer agreement (κ = 0.483. Inter-observer agreement was higher in the Mason (κ = 0.429-0.560 and Morrey (κ = 0.319-0.487 classifications than in the AO/ASIF classification (κ = 0.250-0.478, which showed poor reliability. Conclusion Inter- and intra-observer agreement of the Mason and Morey classifications showed overall satisfactory reliability when compared to the AO/ASIF system. The Mason classification is the most reliable system.

  18. Ratio-scaling of listener preference of multichannel reproduced sound

    DEFF Research Database (Denmark)

    Choisel, Sylvain; Wickelmaier, Florian

    2005-01-01

    -trivial assumption in the case of complex spatial sounds. In the present study the Bradley-Terry-Luce (BTL) model was employed to investigate the unidimensionality of preference judgments made by 40 listeners on multichannel reproduced sound. Short musical excerpts played back in eight reproduction modes (mono......, stereo and various multichannel formats) served as stimuli. On each trial, the task of the subjects was to choose the format they preferred, proceeding through all the possible pairs of the eight reproduction modes. This experiment was replicated with four types of programme material (pop and classical...... music). As a main result, the BTL model was found to predict the choice frequencies well. This implies that listeners were able to integrate the complex nature of the sounds into a unidimensional preference judgment. It further implies the existence of a preference scale on which the reproduction modes...

  19. Examining Management Success Potential.

    Science.gov (United States)

    Quatrano, Louis A.

    The derivation of a model of management success potential in hospitals or health services administration is described. A questionnaire developed to assess management success potential in health administration students was voluntarily completed by approximately 700 incoming graduate students in 35 university health services administration programs…

  20. Reproducible gene targeting in recalcitrant Escherichia coli isolates

    Directory of Open Access Journals (Sweden)

    De Greve Henri

    2011-06-01

    Full Text Available Abstract Background A number of allele replacement methods can be used to mutate bacterial genes. For instance, the Red recombinase system of phage Lambda has been used very efficiently to inactivate chromosomal genes in E. coli K-12, through recombination between regions of homology. However, this method does not work reproducibly in some clinical E. coli isolates. Findings The procedure was modified by using longer homologous regions (85 bp and 500-600 bp, to inactivate genes in the uropathogenic E. coli strain UTI89. An lrhA regulator mutant, and deletions of the lac operon as well as the complete type 1 fimbrial gene cluster, were obtained reproducibly. The modified method is also functional in other recalcitrant E. coli, like the avian pathogenic E. coli strain APEC1. The lrhA regulator and lac operon deletion mutants of APEC1 were successfully constructed in the same way as the UTI89 mutants. In other avian pathogenic E. coli strains (APEC3E, APEC11A and APEC16A it was very difficult or impossible to construct these mutants, with the original Red recombinase-based method, with a Red recombinase-based method using longer (85 bp homologous regions or with our modified protocol, using 500 - 600 bp homologous regions. Conclusions The method using 500-600 bp homologous regions can be used reliably in some clinical isolates, to delete single genes or entire operons by homologous recombination. However, it does not invariably show a greater efficiency in obtaining mutants, when compared to the original Red-mediated gene targeting method or to the gene targeting method with 85 bp homologous regions. Therefore the length of the homology regions is not the only limiting factor for the construction of mutants in these recalcitrant strains.

  1. Illusory Motion Reproduced by Deep Neural Networks Trained for Prediction

    Directory of Open Access Journals (Sweden)

    Eiji Watanabe

    2018-03-01

    Full Text Available The cerebral cortex predicts visual motion to adapt human behavior to surrounding objects moving in real time. Although the underlying mechanisms are still unknown, predictive coding is one of the leading theories. Predictive coding assumes that the brain's internal models (which are acquired through learning predict the visual world at all times and that errors between the prediction and the actual sensory input further refine the internal models. In the past year, deep neural networks based on predictive coding were reported for a video prediction machine called PredNet. If the theory substantially reproduces the visual information processing of the cerebral cortex, then PredNet can be expected to represent the human visual perception of motion. In this study, PredNet was trained with natural scene videos of the self-motion of the viewer, and the motion prediction ability of the obtained computer model was verified using unlearned videos. We found that the computer model accurately predicted the magnitude and direction of motion of a rotating propeller in unlearned videos. Surprisingly, it also represented the rotational motion for illusion images that were not moving physically, much like human visual perception. While the trained network accurately reproduced the direction of illusory rotation, it did not detect motion components in negative control pictures wherein people do not perceive illusory motion. This research supports the exciting idea that the mechanism assumed by the predictive coding theory is one of basis of motion illusion generation. Using sensory illusions as indicators of human perception, deep neural networks are expected to contribute significantly to the development of brain research.

  2. Climate change communication through networks and partnerships: A successful model of engaging and educating non-specialist audience in India

    Science.gov (United States)

    Choudhary, S.; Nayak, R.; Gore, A.

    2013-12-01

    There is an overwhelming international scientific consensus on climate change; however, the global community still lacks the resolve to implement meaningful solutions. No meaningful solutions can be found without educating and engaging non-scientific community in addressing the climate change. With more than 41 percent of world's population falling under 10-34 years age group, the future citizens, inspiring them is a great challenge for the climate scientists. In order to educate the youth and students in India, a model program named 'Climeducate' was created with the help of scientists in Indian Polar Research Network (IPRN), trained climate leaders in ';The Climate Reality Project', and a local organization (Planature Consultancy Services). This model was developed keeping in mind the obstacles that may be faced in reaching out to non-specialist audiences in different parts of India. The identified obstacles were 1- making such a presentation that could reveal the truth about the climate crisis in a way that ignites the moral courage in non-specialist audience 2- lack of funding for travel and boarding expenses of a climate communicator, 3- language barrier in educating local audiences, 4- logistical arrangements at the venue. In this presentation we will share how all the four obstacles were overcome. Audiences were also given short questionnaires before and after the presentation. Remarkable changes in the pattern of answers, data would be shared in the presentation, were observed between the two questionnaires. More importantly, a significant difference in audience engagement was observed comparing a presentation that integrated scientific data with audiovisuals prepared by The Climate Reality Project Chairman, Al Gore (also Former US Vice President) and the other using simple PowerPoint slides. With the success of this program which was implemented among 500 audiences in the eastern India, we aim to replicate this program soon in other parts of India. This

  3. Citation Success

    DEFF Research Database (Denmark)

    Di Vaio, Gianfranco; Waldenström, Daniel; Weisdorf, Jacob Louis

    This study analyses determinants of citation success among authors publishing in economic history journals. Bibliometric features, like article length and number of authors, are positively correlated with the citation rate up to a certain point. Remarkably, publishing in top-ranked journals hardl...

  4. Project Success.

    Science.gov (United States)

    Baehr, Rufus F.

    This report reviews the remedial education program--Project Success--at the Urban Education Center, City Colleges of Chicago (Illinois). The major features of the program are outlined and its operation and evaluation are discussed. Student performance and characteristics are then tabularly compared, based on their groupings as…

  5. Proposal of a social alliance success model from a relationship marketing perspective: A meta-analytical study of the theoretical foundations

    Directory of Open Access Journals (Sweden)

    María Jesús Barroso-Méndez

    2015-07-01

    Full Text Available Partnerships between businesses and non-governmental organizations (NGOs have become widely adopted mechanisms for collaboration in addressing complex social issues, the aim being to take advantage of the two types of organizational rationale to generate mutual value. Many such alliances have proved to be unsuccessful, however. To assist managers improve the likelihood of success of their collaborative relationships, the authors propose a success model of business-NGO partnering processes based on Relationship Marketing Theory. They also analyse the theoretical bases of the model's hypotheses through a meta-analytical study of the existing literature.

  6. ANALYSIS OF INFORMATION SYSTEM IMPLEMENTATION IN BINUS UNIVERSITY USING DELONE AND MCLEAN INFORMATION SYSTEM SUCCESS MODEL AND COBIT FRAMEWORK

    OpenAIRE

    Johan Muliadi Kerta; Angellia Debora Suryawan

    2013-01-01

    The success of implementation of information system in an organization will supportthe organization in the process of achieving goals. Successful information system will support theorganization's day-to-day operations, so that problem can be resolved more quickly and easily. Theinformation system which has been developed and implemented is also necessary to measure thematurity level. Therefore, it can determine whether the implementation of information systemsmade in accordance with the goals...

  7. Comparison on models for genetic evaluation of non-return rate and success in first insemination of the Danish Holstein cow

    DEFF Research Database (Denmark)

    Sun, C; Su, G

    2010-01-01

    The aim of is study was to compare a linear Gaussian model with logit model and probit model for genetic evaluation of non-return rate within 56 d after first-insemination (NRR56) and success in first insemination (SFI). The whole dataset used in the analysis contained 471,742 records from...... the first lactation of the Danish Holstein cows, covering insemination year from 1995 to 2004. Model stability was evaluated by the correlation between sire EBV (estimated breeding values) from two sub-datasets. The predictive ability of models was assessed by two criteria: 1) the correlation between...

  8. Three-dimensional regional-scale hydrostratigraphic modeling based on sequence stratigraphic methods: a case study of the Miocene succession in Denmark

    Science.gov (United States)

    Scharling, Peter B.; Rasmussen, Erik S.; Sonnenborg, Torben O.; Engesgaard, Peter; Hinsby, Klaus

    2009-12-01

    A sound hydrogeological model is the heart of every well-performing groundwater model. A sequence stratigraphic approach has been tested, which has been widely used in the petroleum industry since the 1980s for the construction of three-dimensional hydrogeological models for sedimentary basins. The sequence stratigraphic interpretation has been established for the Miocene succession in western Denmark based on seismic profiles, gamma-ray logs, sediment descriptions and palynological analysis of borehole samples. The up to 400-m-thick Miocene succession consists of deposits originating from deep marine to terrestrial depositional environments. The succession is subdivided into six sequences, corresponding system tracts and distinct lithofacies covering the period from late Oligocene to latest late Miocene. The final model is converted into a binary three-dimensional model that shows the location, geometry and thicknesses of potential deep aquifers, and is prepared for groundwater flow modeling. The model provides a qualified geological description of the connectivity between deep sand formations and the ground surface. By comparison to a traditional lithofacies model based on sediment descriptions of borehole samples, it is shown that the new method gives a more sound geological understanding, which is essential when flow paths and the vulnerability of deep aquifers are evaluated.

  9. Measuring the success of business-intelligence systems in South Africa: An empirical investigation applying the DeLone and McLean Model

    Directory of Open Access Journals (Sweden)

    Taurayi Mudzana

    2015-12-01

    Full Text Available Background: Business intelligence systems (BIS hold promise for improving organisational decision-making in South Africa. Yet, the use of BIS has been associated with a number of challenges. Objectives: The aim of the study was to identify post implementation factors that contribute to the success of BIS in South African organisations. Method: This study draws on the DeLone and McLean Model of Information Systems success and recent literature on business-intelligence (BI to develop and test a BIS success model. A quantitative study was conducted in the form of a survey of 102 BI users to validate the BIS success model. Results: Five interrelated factors of BIS success were confirmed. The study found that the quality of information has a strong influence on system use and user satisfaction. It was found that system quality is positively associated with user satisfaction. The results also indicated that service quality is negatively related to user satisfaction. The study also found that user satisfaction is positively associated with nett benefits of a BI system. Conclusion: The study provides insights for both managers and practitioners on the factors to focus on when implementing BIS thereby minimising the adoption risks associated with BI failures.

  10. Computational cell model based on autonomous cell movement regulated by cell-cell signalling successfully recapitulates the "inside and outside" pattern of cell sorting

    Directory of Open Access Journals (Sweden)

    Ajioka Itsuki

    2007-09-01

    Full Text Available Abstract Background Development of multicellular organisms proceeds from a single fertilized egg as the combined effect of countless numbers of cellular interactions among highly dynamic cells. Since at least a reminiscent pattern of morphogenesis can be recapitulated in a reproducible manner in reaggregation cultures of dissociated embryonic cells, which is known as cell sorting, the cells themselves must possess some autonomous cell behaviors that assure specific and reproducible self-organization. Understanding of this self-organized dynamics of heterogeneous cell population seems to require some novel approaches so that the approaches bridge a gap between molecular events and morphogenesis in developmental and cell biology. A conceptual cell model in a computer may answer that purpose. We constructed a dynamical cell model based on autonomous cell behaviors, including cell shape, growth, division, adhesion, transformation, and motility as well as cell-cell signaling. The model gives some insights about what cellular behaviors make an appropriate global pattern of the cell population. Results We applied the model to "inside and outside" pattern of cell-sorting, in which two different embryonic cell types within a randomly mixed aggregate are sorted so that one cell type tends to gather in the central region of the aggregate and the other cell type surrounds the first cell type. Our model can modify the above cell behaviors by varying parameters related to them. We explored various parameter sets with which the "inside and outside" pattern could be achieved. The simulation results suggested that direction of cell movement responding to its neighborhood and the cell's mobility are important for this specific rearrangement. Conclusion We constructed an in silico cell model that mimics autonomous cell behaviors and applied it to cell sorting, which is a simple and appropriate phenomenon exhibiting self-organization of cell population. The model

  11. GeoTrust Hub: A Platform For Sharing And Reproducing Geoscience Applications

    Science.gov (United States)

    Malik, T.; Tarboton, D. G.; Goodall, J. L.; Choi, E.; Bhatt, A.; Peckham, S. D.; Foster, I.; Ton That, D. H.; Essawy, B.; Yuan, Z.; Dash, P. K.; Fils, G.; Gan, T.; Fadugba, O. I.; Saxena, A.; Valentic, T. A.

    2017-12-01

    Recent requirements of scholarly communication emphasize the reproducibility of scientific claims. Text-based research papers are considered poor mediums to establish reproducibility. Papers must be accompanied by "research objects", aggregation of digital artifacts that together with the paper provide an authoritative record of a piece of research. We will present GeoTrust Hub (http://geotrusthub.org), a platform for creating, sharing, and reproducing reusable research objects. GeoTrust Hub provides tools for scientists to create `geounits'--reusable research objects. Geounits are self-contained, annotated, and versioned containers that describe and package computational experiments in an efficient and light-weight manner. Geounits can be shared on public repositories such as HydroShare and FigShare, and also using their respective APIs reproduced on provisioned clouds. The latter feature enables science applications to have a lifetime beyond sharing, wherein they can be independently verified and trust be established as they are repeatedly reused. Through research use cases from several geoscience laboratories across the United States, we will demonstrate how tools provided from GeoTrust Hub along with Hydroshare as its public repository for geounits is advancing the state of reproducible research in the geosciences. For each use case, we will address different computational reproducibility requirements. Our first use case will be an example of setup reproducibility which enables a scientist to set up and reproduce an output from a model with complex configuration and development environments. Our second use case will be an example of algorithm/data reproducibility, where in a shared data science model/dataset can be substituted with an alternate one to verify model output results, and finally an example of interactive reproducibility, in which an experiment is dependent on specific versions of data to produce the result. Toward this we will use software and data

  12. Successful human infection with P. falciparum using three aseptic Anopheles stephensi mosquitoes: a new model for controlled human malaria infection.

    Directory of Open Access Journals (Sweden)

    Matthew B Laurens

    Full Text Available Controlled human malaria infection (CHMI is a powerful method for assessing the efficacy of anti-malaria vaccines and drugs targeting pre-erythrocytic and erythrocytic stages of the parasite. CHMI has heretofore required the bites of 5 Plasmodium falciparum (Pf sporozoite (SPZ-infected mosquitoes to reliably induce Pf malaria. We reported that CHMI using the bites of 3 PfSPZ-infected mosquitoes reared aseptically in compliance with current good manufacturing practices (cGMP was successful in 6 participants. Here, we report results from a subsequent CHMI study using 3 PfSPZ-infected mosquitoes reared aseptically to validate the initial clinical trial. We also compare results of safety, tolerability, and transmission dynamics in participants undergoing CHMI using 3 PfSPZ-infected mosquitoes reared aseptically to published studies of CHMI using 5 mosquitoes. Nineteen adults aged 18-40 years were bitten by 3 Anopheles stephensi mosquitoes infected with the chloroquine-sensitive NF54 strain of Pf. All 19 participants developed malaria (100%; 12 of 19 (63% on Day 11. The mean pre-patent period was 258.3 hours (range 210.5-333.8. The geometric mean parasitemia at first diagnosis by microscopy was 9.5 parasites/µL (range 2-44. Quantitative polymerase chain reaction (qPCR detected parasites an average of 79.8 hours (range 43.8-116.7 before microscopy. The mosquitoes had a geometric mean of 37,894 PfSPZ/mosquito (range 3,500-152,200. Exposure to the bites of 3 aseptically-raised, PfSPZ-infected mosquitoes is a safe, effective procedure for CHMI in malaria-naïve adults. The aseptic model should be considered as a new standard for CHMI trials in non-endemic areas. Microscopy is the gold standard used for the diagnosis of Pf malaria after CHMI, but qPCR identifies parasites earlier. If qPCR continues to be shown to be highly specific, and can be made to be practical, rapid, and standardized, it should be considered as an alternative for diagnosis

  13. Successful aging.

    Science.gov (United States)

    Vaillant, G E; Mukamal, K

    2001-06-01

    Until now, prospective studies of aging have begun with 50-60-year-olds, not adolescents. Premature death, childhood variables, and alcohol abuse have been often ignored, as has successful aging. The authors reviewed the existing literature on health in late life in order to highlight that, increasingly, successful aging is not an oxymoron. The present study followed two cohorts of adolescent boys (237 college students and 332 core-city youth) for 60 years or until death. Complete physical examinations were obtained every 5 years and psychosocial data every 2 years. Predictor variables assessed before age 50 included six variables reflecting uncontrollable factors: parental social class, family cohesion, major depression, ancestral longevity, childhood temperament, and physical health at age 50 and seven variables reflecting (at least some) personal control: alcohol abuse, smoking, marital stability, exercise, body mass index, coping mechanisms, and education. The six outcome variables chosen to assess successful aging at age 70-80 included four objectively assessed variables (physical health, death and disability before age 80, social supports, and mental health) and two self-rated variables (instrumental activities of daily living and life enjoyment). Multivariate analysis suggested that "good" and "bad" aging from age 70-80 could be predicted by variables assessed before age 50. More hopeful still, if the seven variables under some personal control were controlled, depression was the only uncontrollable predictor variable that affected the quality of subjective and objective aging. One may have greater personal control over one's biopsychosocial health after retirement than previously recognized.

  14. Semiautomated, Reproducible Batch Processing of Soy

    Science.gov (United States)

    Thoerne, Mary; Byford, Ivan W.; Chastain, Jack W.; Swango, Beverly E.

    2005-01-01

    A computer-controlled apparatus processes batches of soybeans into one or more of a variety of food products, under conditions that can be chosen by the user and reproduced from batch to batch. Examples of products include soy milk, tofu, okara (an insoluble protein and fiber byproduct of soy milk), and whey. Most processing steps take place without intervention by the user. This apparatus was developed for use in research on processing of soy. It is also a prototype of other soy-processing apparatuses for research, industrial, and home use. Prior soy-processing equipment includes household devices that automatically produce soy milk but do not automatically produce tofu. The designs of prior soy-processing equipment require users to manually transfer intermediate solid soy products and to press them manually and, hence, under conditions that are not consistent from batch to batch. Prior designs do not afford choices of processing conditions: Users cannot use previously developed soy-processing equipment to investigate the effects of variations of techniques used to produce soy milk (e.g., cold grinding, hot grinding, and pre-cook blanching) and of such process parameters as cooking times and temperatures, grinding times, soaking times and temperatures, rinsing conditions, and sizes of particles generated by grinding. In contrast, the present apparatus is amenable to such investigations. The apparatus (see figure) includes a processing tank and a jacketed holding or coagulation tank. The processing tank can be capped by either of two different heads and can contain either of two different insertable mesh baskets. The first head includes a grinding blade and heating elements. The second head includes an automated press piston. One mesh basket, designated the okara basket, has oblong holes with a size equivalent to about 40 mesh [40 openings per inch (.16 openings per centimeter)]. The second mesh basket, designated the tofu basket, has holes of 70 mesh [70 openings

  15. Precision and reproducibility in AMS radiocarbon measurements.

    Energy Technology Data Exchange (ETDEWEB)

    Hotchkis, M.A.; Fink, D.; Hua, Q.; Jacobsen, G.E.; Lawson, E. M.; Smith, A.M.; Tuniz, C. [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia)

    1996-12-31

    Accelerator Mass Spectrometry (AMS) is a technique by which rare radioisotopes such as {sup 14}C can be measured at environmental levels with high efficiency. Instead of detecting radioactivity, which is very weak for long-lived environmental radioisotopes, atoms are counted directly. The sample is placed in an ion source, from which a negative ion beam of the atoms of interest is extracted, mass analysed, and injected into a tandem accelerator. After stripping to positive charge states in the accelerator HV terminal, the ions are further accelerated, analysed with magnetic and electrostatic devices and counted in a detector. An isotopic ratio is derived from the number of radioisotope atoms counted in a given time and the beam current of a stable isotope of the same element, measured after the accelerator. For radiocarbon, {sup 14}C/{sup 13}C ratios are usually measured, and the ratio of an unknown sample is compared to that of a standard. The achievable precision for such ratio measurements is limited primarily by {sup 14}C counting statistics and also by a variety of factors related to accelerator and ion source stability. At the ANTARES AMS facility at Lucas Heights Research Laboratories we are currently able to measure {sup 14}C with 0.5% precision. In the two years since becoming operational, more than 1000 {sup 14}C samples have been measured. Recent improvements in precision for {sup 14}C have been achieved with the commissioning of a 59 sample ion source. The measurement system, from sample changing to data acquisition, is under common computer control. These developments have allowed a new regime of automated multi-sample processing which has impacted both on the system throughput and the measurement precision. We have developed data evaluation methods at ANTARES which cross-check the self-consistency of the statistical analysis of our data. Rigorous data evaluation is invaluable in assessing the true reproducibility of the measurement system and aids in

  16. [Succession caused by beaver (Castor fiber L.) life activity: I. What is learnt from the calibration of a simple Markov model].

    Science.gov (United States)

    Logofet, D O; Evstigneev, O I; Aleĭnikov, A A; Morozova, A O

    2014-01-01

    A homogeneous Markov chain of three aggregated states "pond--swamp--wood" is proposed as a model of cyclic zoogenic successions caused by beaver (Castor fiber L.) life activity in a forest biogeocoenosis. To calibrate the chain transition matrix, the data have appeared sufficient that were gained from field studies undertaken in "Bryanskii Les" Reserve in the years of 2002-2008. Major outcomes of the calibrated model ensue from the formulae of finite homogeneous Markov chain theory: the stationary probability distribution of states, thematrix (T) of mean first passage times, and the mean durations (M(j)) of succession stages. The former illustrates the distribution of relative areas under succession stages if the current trends and transition rates of succession are conserved in the long-term--it has appeared close to the observed distribution. Matrix T provides for quantitative characteristics of the cyclic process, specifying the ranges the experts proposed for the duration of stages in the conceptual scheme of succession. The calculated values of M(j) detect potential discrepancies between empirical data, the expert knowledge that summarizes the data, and the postulates accepted in the mathematical model. The calculated M2 value falls outside the expert range, which gives a reason to doubt the validity of expert estimation proposed, the aggregation mode chosen for chain states, or/and the accuracy-of data available, i.e., to draw certain "lessons" from partially successful calibration. Refusal to postulate the time homogeneity or the Markov property of the chain is also discussed among possible ways to improve the model.

  17. Goal orientation as a motivation model and self-confidence among tennis players of different levels of success

    Directory of Open Access Journals (Sweden)

    Lepir Duško

    2014-01-01

    Full Text Available The goal of this research was to determine differences between the successful and less successful tennis players regarding their goal orientation and self-confidence, as well as to examine the correlation between these two psychological constructs. Active male tennis players (N=40, ranked on the senior list of the Tennis Federation of Austria, age 18 to 26, filled in the TEOSQ-D1 questionnaire (Würth, Alfermann and Saborowski, 1999, and CSI questionnaire (Vealey, 1986, just before the national senior championship of Austria. After categorising a 'successful tennis player' as one ranked in top 100 (N=20, and a 'less successful' one as ranked outside top 100 (N=20, analyses of their differences concerning goal orientation and self-confidence were conducted by means of the T-test, but no statistically significant differences were found for any scale. Pearson's coefficient for the entire sample showed that task orientation correlate significantly with the sport confidence trait (r= 0,451; Sig.= 0,05, and to a certain extent with sport-confidence as a state (r= 0,387; Sig.= 0,092, but that correlation is not statistically significant at the level Sig.< 0,05. For the result/ego scale orientation, there were no significant correlations with sporting-confidence. Guidelines for future research are based on the development of a more adequate system for evaluation of success in sport, and also on increasing of sample size. This could be very helpful for making more reliable conclusions about the influence of goal orientation preference on sport-confidence and sport success, which could justify the utilization of this psychological construct for practical purposes.

  18. Quark/gluon jet discrimination: a reproducible analysis using R

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    The power to discriminate between light-quark jets and gluon jets would have a huge impact on many searches for new physics at CERN and beyond. This talk will present a walk-through of the development of a prototype machine learning classifier for differentiating between quark and gluon jets at experiments like those at the Large Hadron Collider at CERN. A new fast feature selection method that combines information theory and graph analytics will be outlined. This method has found new variables that promise significant improvements in discrimination power. The prototype jet tagger is simple, interpretable, parsimonious, and computationally extremely cheap, and therefore might be suitable for use in trigger systems for real-time data processing. Nested stratified k-fold cross validation was used to generate robust estimates of model performance. The data analysis was performed entirely in the R statistical programming language, and is fully reproducible. The entire analysis workflow is data-driven, automated a...

  19. Critical success factors for the transition to business models for sustainability in the food and beverage industry in the Netherlands

    NARCIS (Netherlands)

    Long, Thomas B.; Looijen, Arnold; Blok, Vincent

    2018-01-01

    Businesses will play a key role in helping the transition towards greater sustainability. To maximise business sustainability performance, sustainability characteristics must be integrated at the business model level, creating business models for sustainability. Creating a business model for

  20. Modelling self-efficacy, self-regulation, self-directed learning and career processes of adult professionals and relations with learning outcomes and labour market success

    OpenAIRE

    Bijker, Monique; Van der Klink, Marcel; Boshuizen, Els

    2010-01-01

    Bijker, M. M., Van der Klink, M. R., & Boshuizen, H. P. A. (2010, 25-27 August). Modelling self-efficacy, self-regulation, self-directed learning and career processes of adult professionals and relations with learning outcomes and labour market success. Paper presented at the 5th EARLI-SIG14 Learning and Professional Development, Munich, Germany.