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Sample records for models offer opportunities

  1. Exotic models may offer unique opportunities to decipher specific scientific question: the case of Xenopus olfactory system.

    Science.gov (United States)

    Gascuel, Jean; Amano, Tosikazu

    2013-09-01

    The fact that olfactory systems are highly conserved in all animal species from insects to mammals allow the generalization of findings from one species to another. Most of our knowledge about the anatomy and physiology of the olfactory system comes from data obtained in a very limited number of biological models such as rodents, Zebrafish, Drosophila, and a worm, Caenorhabditis elegans. These models have proved useful to answer most questions in the field of olfaction, and thus concentrating on these few models appear to be a pragmatic strategy. However, the diversity of the organization and physiology of the olfactory system amongst phyla appear to be greater than generally assumed and the four models alone may not be sufficient to address all the questions arising from the study of olfaction. In this article, we will illustrate the idea that we should take advantage of biological diversity to address specific scientific questions and will show that the Xenopus olfactory system is a very good model to investigate: first, olfaction in aerial versus aquatic conditions and second, mechanisms underlying postnatal reorganization of the olfactory system especially those controlled by tyroxine hormone.

  2. Changing Technologies Offer New Opportunities in the Plant Sciences

    Directory of Open Access Journals (Sweden)

    Theresa M. Culley

    2013-01-01

    Full Text Available The plant sciences are now facing an unprecedented time in our history in which technology is advancing at a rapid pace, creating a wide variety of novel opportunities for our field. Applications in Plant Sciences is a new source for sharing exciting and innovative applications of new technologies that have the potential to propel plant research forward into the future.

  3. Smartphones Offer New Opportunities in Clinical Voice Research.

    Science.gov (United States)

    Manfredi, C; Lebacq, J; Cantarella, G; Schoentgen, J; Orlandi, S; Bandini, A; DeJonckere, P H

    2017-01-01

    Smartphone technology provides new opportunities for recording standardized voice samples of patients and sending the files by e-mail to the voice laboratory. This drastically improves the collection of baseline data, as used in research on efficiency of voice treatments. However, the basic requirement is the suitability of smartphones for recording and digitizing pathologic voices (mainly characterized by period perturbations and noise) without significant distortion. In this experiment, two smartphones (a very inexpensive one and a high-level one) were tested and compared with direct microphone recordings in a soundproof room. The voice stimuli consisted in synthesized deviant voice samples (median of fundamental frequency: 120 and 200 Hz) with three levels of jitter and three levels of added noise. All voice samples were analyzed using PRAAT software. The results show high correlations between jitter, shimmer, and noise-to-harmonics ratio measured on the recordings via both smartphones, the microphone, and measured directly on the sound files from the synthesizer. Smartphones thus appear adequate for reliable recording and digitizing of pathologic voices. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  4. Offers

    CERN Multimedia

    Staff Association

    2011-01-01

    Special offers for our members       Go Sport in Val Thoiry is offering 15% discount on all purchases made in the shop upon presentation of the Staff Association membership card (excluding promotions, sale items and bargain corner, and excluding purchases using Go Sport  and Kadéos gift cards. Only one discount can be applied to each purchase).  

  5. Offers

    CERN Multimedia

    Staff Association

    2012-01-01

    L'Occitane en Provence proposes the following offer: 10 % discount on all products in all L'Occitane shops in Metropolitan France upon presentation of your Staff Association membership card and a valid ID. This offer is valid only for one person, is non-transferable and cannot be combined with other promotions.

  6. Offers

    CERN Multimedia

    Staff Association

    2014-01-01

    New offers : Discover the theater Galpon in Geneva. The Staff Association is happy to offer to its members a discount of 8.00 CHF on a full-price ticket (tickets of 15.00 CHF instead of 22.00 CHF) so do not hesitate anymore (mandatory reservation by phone + 4122 321  21 76 as tickets are quickly sold out!). For further information, please see our website: http://staff-association.web.cern.ch/fr/content/th%C3%A9%C3%A2tre-du-galpon  

  7. Offer

    CERN Multimedia

    Staff Association

    2016-01-01

    CERN was selected and participated in the ranking "Best Employers" organized by the magazine Bilan. To thank CERN for its collaboration, the magazine offers a reduction to the subscription fee for all employed members of personnel. 25% off the annual subscription: CHF 149.25 instead of CHF 199 .— The subscription includes the magazine delivered to your home for a year, every other Wednesday, as well as special editions and access to the e-paper. To benefit from this offer, simply fill out the form provided for this purpose. To get the form, please contact the secretariat of the Staff Association (Staff.Association@cern.ch).

  8. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    SPECIAL OFFER FOR OUR MEMBERS Prices Spring and Summer 2013 Day ticket: same price weekends, public holidays and weekdays: Children from 5 to 15 years old: 30 CHF instead of 39 CHF Adults from 16 years old: 36 CHF instead of 49 CHF Bonus! Free for children under 5 Tickets available at the Staff Association Secretariat.

  9. Offers

    CERN Multimedia

    Association du personnel

    2013-01-01

    SPECIAL OFFER FOR OUR MEMBERS Prices Spring and Summer 2013 Day ticket: same price weekends, public holidays and weekdays: – Children from 5 to 15 years old: 30 CHF instead of 39 CHF – Adults from 16 years old: 36 CHF instead of 49 CHF – Bonus! Free for children under 5 Tickets available at the Staff Association Secretariat.

  10. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    The theater season will start again, so do not hesitate to benefit from our discount: Théâtre de Carouge : Discount for all shows and on various season tickets. La Comédie : reduction on various tickets, on annual subscriptions and on discounted card. For further information, see our website: http://staff-association.web.cern.ch/sociocultural/offers

  11. Offers

    CERN Multimedia

    Staff Association

    2012-01-01

    proposes the following offer: 15% discount for the Staff Association members who enroll their children in summer FUTUREKIDS activities. Extracurricular Activities For Your Children The FUTUREKIDS Geneva Learning Center is open 6 days a week and offers a selection of after-school extracurricular activities for children and teenagers (ages 5 to 16). In addition to teaching in its Learning Centers, Futurekids collaborates with many private schools in Suisse Romande (Florimont, Moser, Champittet, Ecole Nouvelle, etc.) and with the Département de l'Instruction Publique (DIP) Genève. Courses and camps are usually in French but English groups can be set up on demand. FUTUREKIDS Computer Camps (during school holidays) FUTUREKIDS Computer Camps are a way of having a great time during vacations while learning something useful, possibly discovering a new hobby or even, why not, a future profession. Our computer camps are at the forefront of technology. Themes are diverse and suit all ...

  12. Offers

    CERN Multimedia

    Staff Association

    2015-01-01

    New offer for our members. The Staff Association CERN staff has recently concluded a framework agreement with AXA Insurance Ltd, General-Guisan-Strasse 40, 8401 Winterthur. This contract allows you to benefit from a preferential tariff and conditions for insurances: Motor vehicles for passenger cars and motorcycles of the product line STRADA: 10% discount Household insurance (personal liability and household contents) the product line BOX: 10% discount Travel insurance: 10% discount Buildings: 10% discount Legal protection: 10% discount AXA is number one on the Swiss insurance market. The product range encompasses all non-life insurance such as insurance of persons, property, civil liability, vehicles, credit and travel as well as innovative and comprehensive solutions in the field of occupational benefits insurance for individuals and businesses. Finally, the affiliate AXA-ARAG (legal expenses insurance) completes the offer. Armed with your staff association CERN card, you can always get the offe...

  13. Offer

    CERN Multimedia

    Staff Association

    2010-01-01

      Special offer for members of the Staff Association and their families 10% reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Plus 20% reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * Next “vente privée” from 22th to 29th November 2010

  14. Offer

    CERN Multimedia

    Staff Association

    2011-01-01

      Special offer for members of the Staff Association and their families 10% reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Plus 20% reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * Next “vente privée” from 25th to 27th March 2011  

  15. Offer

    CERN Multimedia

    CARLSON WAGONLIT TRAVEL

    2011-01-01

    Special offer   From 14th to 28th February 2011: no CWT service fee! For any new reservation of a holiday package (flight + hotel/apartment) from a catalog “summer 2011” For any additional information our staff is at your disposal from Monday – Friday, from 8h30 to 16h30. Phone number 72763 or 72797 Carlson Wagonlit Tavel, Agence du CERN  

  16. Offers

    CERN Multimedia

    Staff Association

    2012-01-01

    SPECIAL OFFER FOR OUR MEMBERS Prices Spring and Summer 2012 Half-day ticket: 5 hours, same price weekends, public holidays and weekdays. Children from 5 to 15 years old: 26 CHF instead of 35 CHF Adults from 16 years old: 32 CHF instead of 43 CHF Bonus! Free for children under 5. Aquaparc Les Caraïbes sur Léman 1807 Le Bouveret (VS)

  17. Offers

    CERN Document Server

    Staff Association

    2012-01-01

    SPECIAL OFFER FOR OUR MEMBERS Single tariff Adulte/Enfant Tickets “Zone terrestre” 20 euros instead of 25 euros. Access to Aqualibi: 5 euros instead of 8 euros on presentation of your ticket SA member. Free for children under 3, with limited access to the attractions. More information on our website : http://association.web.cern.ch/association/en/OtherActivities/Walibi.html

  18. Offers

    CERN Multimedia

    Staff Association

    2011-01-01

    Banque cantonale de Genève (BCGE) The BCGE Business partner programme devised for members of the CERN Staff Association offers personalized banking solutions with preferential conditions. The advantages are linked to salary accounts (free account keeping, internet banking, free Maestro and credit cards, etc.), mortgage lending, retirement planning, investment, credit, etc. The details of the programme and the preferential conditions are available on our website: http://association.web.cern.ch/association/en/OtherActivities/BCGE.html.  

  19. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    Special offer for members of the Staff Association and their families 10 % reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Plus 20 % reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * Next “vente privée” from 11th to 23rd November 2013 Please contact the Staff Association Secretariat to get the discount voucher.  

  20. Offers

    CERN Multimedia

    Staff Association

    2012-01-01

    Special offer for members of the Staff Association and their families 10% reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Plus 20% reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * Next “vente privée” from 21st to 26th May 2012 Please contact the Staff Association Secretariat to get the discount voucher  

  1. Offers

    CERN Multimedia

    Staff Association

    2012-01-01

    Special offer for members of the Staff Association and their families 10 % reduction on all products in the Sephora shop (sells perfume, beauty products etc.) in Val Thoiry all year round. Plus 20 % reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * next “vente privée” from 21st November to 1st December 2012 Please contact the Staff Association Secretariat to get the discount voucher.

  2. Offers

    CERN Multimedia

    Staff Association

    2014-01-01

    Passeport Gourmand   Are you dying for a nice meal? The “Passeport Gourmand” offers discounted prices to the members of the Staff Association (available until April 2015 and on sale in the Staff Association Secretariat): Passeport gourmand Ain / Savoie/ Haute Savoie: 56 CHF instead of 79 CHF. Passeport gourmand Geneva / neighbouring France:72 CHF instead of 95 CHF. To the members of the Staff Association: Benefit of reduced tickets: CHF 10 (instead of  18 CHF at the desk) on sale to the secretariat of the Staff Association, Building 510-R010 (in front of the Printshop).

  3. Offers

    CERN Multimedia

    Staff Association

    2014-01-01

    Special offer for members of the Staff Association and their families 10 % reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Simply present your Staff Association membership card when you make your purchase. Plus 20 % reduction during their “vente privée”* three or four times a year. * Next “vente privée” from 24th September to 6th November 2014 Please contact the Staff Association Secretariat to get the discount voucher.  

  4. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    The « Théâtre de Carouge » offers a 5.- CHF discount for all shows (30.- CHF instead of 35.- CHF) and for the season tickets "Premières représentations" (132.- CHF instead of 162.- CHF) and "Classique" (150.- CHF instead of 180.- CHF). Please send your reservation by email to smills@tcag.ch via your professional email address. Please indicate the date of your reservation, your name and firstname and your telephone number A confirmation will be sent by email. Your membership card will be asked when you collect the tickets. More information on www.tcag.ch and www.tcag.ch/blog/

  5. Offers

    CERN Multimedia

    Staff Association

    2015-01-01

    New season 2015-2016 The new season was revealed in May, and was warmly welcomed by the press, which is especially enthusiastic about the exceptional arrival of Fanny Ardand in September in the framework of Cassandre show. Discover the programme 2015-2016. The theatre La Comédie proposes different offers to our members Benefit from a reduction of 20 % on a full price ticket during all the season: from 38 CHF to 23 CHF ticket instead of 50 CHF to 30 CHF depending on the show. Buy two seasonal tickets at the price of one (offers valid upon availability, and until 30 september 2015) 2 Cards Libertà for 240 CHF instead of 480 CHF. Cruise freely through the season with 8 perfomances of your choice per season. These cards are transferrable, and can be shared with one or more accompanying persons. 2 Abo Piccolo for 120 CHF instead of 240 CHF. Let yourself be surprised a theatre performance with our discovery seasonal tickets, which includes 4 flagship perfomances for the season. ...

  6. Offer

    CERN Multimedia

    Staff Association

    2015-01-01

    RRP Communication organizes cultural events such as concerts, shows, sporting events. The members of the Staff Association profits from a reduction of 10 CHF per ticket. How to proceed: The ticket reservation is made by mail info@rrp.ch. You need to give the following information: Name of the show, and which date chosen Number of tickets, and category Name and surname Address Telephone number Mention “offer CERN”, and attach a photocopy of your Staff Association member card. After your reservation, you will be sent a copy with a payslip to the address mentioned above. Once paid, the members have the possibility to: pick up their ticket(s) from the cash register the evening of the show (opens 1 hour before the show) by showing their member card; receive the ticket(s) to the address indicated above, by registered mail, subject to an extra cost of 10CHF. Next show : More information at http://www.rrp.ch/

  7. Offers

    CERN Document Server

    Staff Association

    2013-01-01

    FUTUREKIDS proposes 15% discount for the Staff Association members who enroll their children in FUTUREKIDS activities. New workshop for 12-15 year olds, on how to develop applications for Android phones. Easter activities calendar Extracurricular Activities For Your Children The FUTUREKIDS Geneva Learning Center is open 6 days a week and offers a selection of after-school extracurricular activities for children and teenagers (ages 5 to 16). In addition to teaching in its Learning Centers, Futurekids collaborates with many private schools in Suisse Romande (Florimont, Moser, Champittet, Ecole Nouvelle, etc.) and with the Département de l'Instruction Publique (DIP) Genève. Courses and camps are usually in French but English groups can be set up on demand. FUTUREKIDS Computer Camps (during school holidays) FUTUREKIDS Computer Camps are a way of having a great time during vacations while learning something useful, possibly discovering a new hobby or even, why not, a fut...

  8. Offers

    CERN Multimedia

    Association du personnel

    2010-01-01

    THEATRE FORUM DE MEYRIN 1, place des Cinq-Continents 1217 Meyrin    Special offer for members of the Staff Association: Reduced ticket prices for the play Love is my sin (in English) from 15 to 17 March at 8.30pm http://www.forum-meyrin.ch/main.php?page=119&s=12   First category: 37 CHF instead of 46 CHF Second category (seats towards the sides): 30 CHF instead of 38 CHF Please present your CERN card and your Staff Association membership card at the ticket office. Ticket reservation: tel. 022 989 34 34 (from Monday to Friday 2pm to 6pm) or e-mail : billetterie@forum-meyrin.ch  

  9. Offer

    CERN Multimedia

    Staff Association

    2011-01-01

    DETAILS OF THE AGREEMENT WITH BCGE The BCGE Business partner programme devised for members of the CERN Staff Association offers personalized banking solutions with preferential conditions. The advantages are linked to salary accounts (free account keeping, internet banking, free Maestro and credit cards, etc.), mortgage lending, retirement planning, investment, credit, etc. The details of the programme and the preferential conditions are available on the Staff Association web site and from the secretariat (http://cern.ch/association/en/OtherActivities/BCGE.html). To benefit from these advantages, you will need to fill in the form available on our site, which must then be stamped by the Staff Association as proof that you are a paid-up member.  

  10. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    Do not hesitate to benefit of our offers in our partners: Théâtre de Carouge Discount of 5 CHF for all shows (30 CHF instead of 35 CHF) and on season tickets « first performance » ( 132 CHF instead 162 CHF) and also on « classical » ( 150 CHF instead of 180 CHF) upon presentation of your Staff Association membership card before payment. Théâtre La Comédie de Genève  20% off on tickets (full price – also available for partner): from 24 to 32 CHF a ticket instead of 30 to 40 CHF depending on the shows. 40% off on annual subscriptions (access to the best seats, pick up tickets at the last minute): 200 CHF for 9 shows (about 22 CHF a ticket instead of 30 to 40 CHF. Discounted card: 60 CHF and single price ticket of 16 CHF.

  11. Offers

    CERN Document Server

    Staff Association

    2011-01-01

    At the UN Cultural kiosk (door C6) This offer is meant for international civil servants, members of diplomatic missions as well as official delegates under presentation of their accreditation card. Matthew Lee & 5 musiciens Du Blues, du Boogie, du Rock’n’Roll 28 octobre 2011 à 20h30 Théâtre du Léman Quai du Mont-Blanc 19 Hôtel Kempinski Genève Matthew Lee is an exciting pianist singer combining classic Rock’n’Roll with timeless ballads. He revisits the standards, being alternately Jerry Lee Lewis, Chuck Berry, Little Richards and many others... He is a showman with a soulful voice and displays virtuosity during his piano solos. Simply amazing! 20 % reduction Tickets from 32 to 68 CHF Kiosque Culturel ONU Palais des Nations Porte 6 Avenue de la Paix 8-14 1211 Genève 10 Tél. 022 917 11 11 info@kiosqueonu.ch

  12. Offer

    CERN Multimedia

    Staff Association

    2016-01-01

    The “La Comédie” theatre unveiled its programme for the season 2016–2017 in late May, and it was met with great enthusiasm by the press. Leading names of the European and Swiss theatre scenes, such as director Joël Pommerat who recently won four Molière awards, will make an appearance! We are delighted to share this brand new, rich and varied programme with you. The “La Comédie” theatre has various discounts for our members Buy 2 subscriptions for the price of 1 : 2 cards “Libertà” for CHF 240.- instead of CHF 480.- Cruise freely through the season with an 8-entry card valid for the shows of your choice. These cards are transferable and can be shared with one or more accompanying persons. 2 cards “Piccolo” for CHF 120 instead of CHF 240.- This card lets you discover 4 shows which are suitable for all audiences (offers valid while stock lasts and until October 31, 201...

  13. Offers

    CERN Multimedia

    Staff Association

    2011-01-01

    Special offer for members of the Staff Association and their families 10% reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Plus 20% reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * Next “vente privée” from 21st to 26th November 2011 New BCGE Business partner benefits As you may remember thanks to our BCGE business partner agreement you benefit from various advantages such as free annual subscription on your Silver or Gold credit card both for yourself and your partner (joint account). Please be informed that as of October 1st  2011 the below mentioned features will be added to your annual credit card subscription : MasterCard/Visa Silver and Gold: travel cancellation as well as related services such as holiday interruption best guaranteed price Only for Ma...

  14. The Race to Refinance Debt: Market Offers Opportunities to Reduce Interest Costs.

    Science.gov (United States)

    DuPont, Lorrie A.

    1992-01-01

    In this interest market, colleges and universities could benefit from careful evaluation of debt portfolios. Refinancing debt is an opportunity to lower debt service costs, ease cash flow, change security pledges, eliminate debt service reserves, update bond documents. Timing is important. Existing and new bonds can also be combined…

  15. Opportunities offered by the raw material boom to German mining machinery manufacturers; Chancen des Rohstoffbooms fuer die deutschen Bergbaumaschinenhersteller

    Energy Technology Data Exchange (ETDEWEB)

    Stoeckmann, K. [Verband Deutscher Maschinen- und Anlagenbau e.V. (VDMA), Frankfurt am Main (Germany). Fachverband Bergbaumaschinen

    2008-05-13

    Since the beginning of the raw material boom four years ago the positive trend in the mining machinery branch in Germany has accelerated. The globalisation of the branch was assisted by the good national and international network between manufacturers of mining equipment, associations, consultants, financial institutions and politicians. The branch is currently well established internationally with an export share of 86%. This puts it into a position to continue to utilise the opportunities offered by the raw material boom. (orig.)

  16. Does the Constellation Program Offer Opportunities to Achieve Space Science Goals in Space?

    Science.gov (United States)

    Thronson, Harley A.; Lester, Daniel F.; Dissel, Adam F.; Folta, David C.; Stevens, John; Budinoff, Jason G.

    2008-01-01

    Future space science missions developed to achieve the most ambitious goals are likely to be complex, large, publicly and professionally very important, and at the limit of affordability. Consequently, it may be valuable if such missions can be upgraded, repaired, and/or deployed in space, either with robots or with astronauts. In response to a Request for Information from the US National Research Council panel on Science Opportunities Enabled by NASA's Constellation System, we developed a concept for astronaut-based in-space servicing at the Earth-Moon L1,2 locations that may be implemented by using elements of NASA's Constellation architecture. This libration point jobsite could be of great value for major heliospheric and astronomy missions operating at Earth-Sun Lagrange points. We explored five alternative servicing options that plausibly would be available within about a decade. We highlight one that we believe is both the least costly and most efficiently uses Constellation hardware that appears to be available by mid-next decade: the Ares I launch vehicle, Orion/Crew Exploration Vehicle, Centaur vehicle, and an airlock/servicing node developed for lunar surface operations. Our concept may be considered similar to the Apollo 8 mission: a valuable exercise before descent by astronauts to the lunar surface.

  17. Does NASA's Constellation Architecture Offer Opportunities to Achieve Multiple Additional Goals in Space?

    Science.gov (United States)

    Thronson, Harley; Lester, Daniel F.

    2008-01-01

    Every major NASA human spaceflight program in the last four decades has been modified to achieve goals in space not incorporated within the original design goals: the Apollo Applications Program, Skylab, Space Shuttle, and International Space Station. Several groups in the US have been identifying major future science goals, the science facilities necessary to investigate them, as well as possible roles for augmented versions of elements of NASA's Constellation program. Specifically, teams in the astronomy community have been developing concepts for very capable missions to follow the James Webb Space Telescope that could take advantage of - or require - free-space operations by astronauts and/or robots. Taking as one example, the Single-Aperture Far-InfraRed (SAFIR) telescope with a approx. 10+ m aperture proposed for operation in the 2020 timeframe. According to current NASA plans, the Ares V launch vehicle (or a variant) will be available about the same time, as will the capability to transport astronauts to the vicinity of the Moon via the Orion Crew Exploration Vehicle and associated systems. [As the lunar surface offers no advantages - and major disadvantages - for most major optical systems, the expensive system for landing and operating on the lunar surface is not required.] Although as currently conceived, SAFIR and other astronomical missions will operate at the Sun-Earth L2 location, it appears trivial to travel for servicing to the more accessible Earth-Moon L1,2 locations. Moreover. as the recent Orbital Express and Automated Transfer Vehicle missions have demonstrated, future robotic capabilities should offer capabilities that would (remotely) extend human presence far beyond the vicinity of the Earth. In addition to multiplying the value of NASA's architecture for future human spaceflight to achieve the goals multiple major stakeholders. if humans one day travel beyond the Earth-Moon system - say, to Mars - technologies and capabilities for operating

  18. Accelerator mass spectrometry offers new opportunities for microdosing of peptide and protein pharmaceuticals.

    Science.gov (United States)

    Salehpour, Mehran; Ekblom, Jonas; Sabetsky, Vladimir; Håkansson, Karl; Possnert, Göran

    2010-05-30

    Accelerator Mass Spectrometry (AMS) is an ultra-sensitive analytical method which has been instrumental in developing microdosing as a strategic tool in early drug development. Considerable data is available for AMS microdosing using typical pharmaceutical drugs with a molecular weight of a few hundred Daltons. The so-called biopharmaceuticals such as proteins offer interesting possibilities as drug candidates; however, experimental data for protein microdosing and AMS is scarce. The analysis of proteins in conjunction with early drug development and microdosing is overviewed and three case studies are presented on the topic. In the first case study AMS experimental data is presented, for the measured concentration of orally administered recombinant insulin in the blood stream of laboratory rabbits. Case study 2 concerns minimum sample size requirements. AMS samples normally require about 1 mg of carbon (10 microL of blood) which makes AMS analysis unsuitable in some applications due to the limited availability of samples such as human biopsies or DNA from specific cells. Experimental results are presented where the sample size requirements have been reduced by about two orders of magnitude. The third case study concerns low concentration studies. It is generally accepted that protein pharmaceuticals may be potentially more hazardous than smaller molecules because of immunological reactions. Therefore, future first-in-man microdosing studies might require even lower exposure concentrations than is feasible today, in order to increase the safety margin. This issue is discussed based on the current available analytical capabilities.

  19. The Undergraduate Teaching Assistant Experience Offers Opportunities Similar to the Undergraduate Research Experience

    Directory of Open Access Journals (Sweden)

    Kelly A. Schalk

    2009-12-01

    Full Text Available There has been a growing concern in higher education about our failure to produce scientifically trained workers and scientifically literate citizens. Active-learning and research-oriented activities are posited as ways to give students a deeper understanding of science. We report on an undergraduate teaching assistant (UTA experience and suggest that students who participate as a UTA obtain benefits analogous to those who participate as an undergraduate research assistant (URA. We examined the experiences of 24 undergraduates acting as UTAs in a general microbiology course. Self-reported gains by the UTAs were supported by observational data from undergraduates in the course who were mentored by the UTAs and by the graduate teaching assistants (GTAs with whom the UTAs worked. Specifically, data from the UTAs’ journals and self-reported Likert scales and rubrics indicated that our teaching assistants developed professional characteristics such as self-confidence and communication and leadership skills, while they acquired knowledge of microbiology content and laboratory skills. Data from the undergraduate Likert scale as well as the pre- and post-GTA rubrics further confirmed our UTA’s data interpretations. These findings are significant because they offer empirical data to support the suggestion that the UTA experience is an effective option for developing skills and knowledge in undergraduates that are essential for careers in science. The UTA experience provides a valuable alternative to the URA experience.

  20. Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities

    Science.gov (United States)

    Parasramka, Mansi A.

    2016-01-01

    Long non-coding RNAs (lncRNA) are critical regulators of gene expression, and can reprogram the transcriptome to modulate cellular processes involved in cellular growth and differentiation, and thereby contribute to tumorigenesis. In addition to effects on tumor cell growth, survival and cell signaling, lncRNA can modulate cancer stem cell (CSC) behavior, including the expression of pluripotency factors. The identification of lncRNA that are mechanistically linked to cancer stem cell self-renewal and differentiation, or aberrant signaling pathways associated with tumor growth or progression, offer new opportunities for therapeutic intervention. PMID:27358893

  1. Olympics Offer Development Opportunities

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    As China begins the two-year countdown to the 2008 Summer Olympic Games slated for August 8-24 in Beijing, the nation, still excited about the realization of a centennial dream, is now pondering the real benefits of hosting such an event Besides the economic returns and an expected elevation of national confidence, people hope the course of Chinese society will also see a revolutionary change. In an interview with China Business News, Wei Jizhong, President of the Beijing Olympic Economy Research Institu...

  2. Computer Aided ModellingOpportunities and Challenges

    DEFF Research Database (Denmark)

    Cameron, Ian; Gani, Rafiqul

    2011-01-01

    -based solutions to significant problems? The important issues of workflow and data flow are discussed together with fit-for-purpose model development. As well, the lack of tools around multiscale modelling provides opportunities for the development of efficient tools to address such challenges. The ability......This chapter considers the opportunities that are present in developing, extending and applying aspects of computer-aided modelling principles and practice. What are the best tasks to be done by modellers and what needs the application of CAPE tools? How do we efficiently develop model...... and opportunities are discussed for such systems....

  3. Computer Aided ModellingOpportunities and Challenges

    DEFF Research Database (Denmark)

    2011-01-01

    This chapter considers the opportunities that are present in developing, extending and applying aspects of computer-aided modelling principles and practice. What are the best tasks to be done by modellers and what needs the application of CAPE tools? How do we efficiently develop model-based solu......This chapter considers the opportunities that are present in developing, extending and applying aspects of computer-aided modelling principles and practice. What are the best tasks to be done by modellers and what needs the application of CAPE tools? How do we efficiently develop model...

  4. Somatic Embryogenesis in Coffee: The Evolution of Biotechnology and the Integration of Omics Technologies Offer Great Opportunities.

    Science.gov (United States)

    Campos, Nádia A; Panis, Bart; Carpentier, Sebastien C

    2017-01-01

    One of the most important crops cultivated around the world is coffee. There are two main cultivated species, Coffea arabica and C. canephora. Both species are difficult to improve through conventional breeding, taking at least 20 years to produce a new cultivar. Biotechnological tools such as genetic transformation, micropropagation and somatic embryogenesis (SE) have been extensively studied in order to provide practical results for coffee improvement. While genetic transformation got many attention in the past and is booming with the CRISPR technology, micropropagation and SE are still the major bottle neck and urgently need more attention. The methodologies to induce SE and the further development of the embryos are genotype-dependent, what leads to an almost empirical development of specific protocols for each cultivar or clone. This is a serious limitation and excludes a general comprehensive understanding of the process as a whole. The aim of this review is to provide an overview of which achievements and molecular insights have been gained in (coffee) somatic embryogenesis and encourage researchers to invest further in the in vitro technology and combine it with the latest omics techniques (genomics, transcriptomics, proteomics, metabolomics, and phenomics). We conclude that the evolution of biotechnology and the integration of omics technologies offer great opportunities to (i) optimize the production process of SE and the subsequent conversion into rooted plantlets and (ii) to screen for possible somaclonal variation. However, currently the usage of the latest biotechnology did not pass the stage beyond proof of potential and needs to further improve.

  5. The NSF Undergraduate ALFALFA Team: Partnering with Arecibo Observatory to Offer Undergraduate and Faculty Extragalactic Radio Astronomy Research Opportunities

    Science.gov (United States)

    Ribaudo, Joseph; Koopmann, Rebecca A.; Haynes, Martha P.; Balonek, Thomas J.; Cannon, John M.; Coble, Kimberly A.; Craig, David W.; Denn, Grant R.; Durbala, Adriana; Finn, Rose; Hallenbeck, Gregory L.; Hoffman, G. Lyle; Lebron, Mayra E.; Miller, Brendan P.; Crone-Odekon, Mary; O'Donoghue, Aileen A.; Olowin, Ronald Paul; Pantoja, Carmen; Pisano, Daniel J.; Rosenberg, Jessica L.; Troischt, Parker; Venkatesan, Aparna; Wilcots, Eric M.; ALFALFA Team

    2017-01-01

    The NSF-sponsored Undergraduate ALFALFA (Arecibo Legacy Fast ALFA) Team (UAT) is a consortium of 20 institutions across the US and Puerto Rico, founded to promote undergraduate research and faculty development within the extragalactic ALFALFA HI blind survey project and follow-up programs. The objective of the UAT is to provide opportunities for its members to develop expertise in the technical aspects of observational radio spectroscopy, its associated data analysis, and the motivating science. Partnering with Arecibo Observatory, the UAT has worked with more than 280 undergraduates and 26 faculty to date, offering 8 workshops onsite at Arecibo (148 undergraduates), observing runs at Arecibo (69 undergraduates), remote observing runs on campus, undergraduate research projects based on Arecibo science (120 academic year and 185 summer projects), and presentation of results at national meetings such as the AAS (at AAS229: Ball et al., Collova et al., Davis et al., Miazzo et al., Ruvolo et al, Singer et al., Cannon et al., Craig et al., Koopmann et al., O'Donoghue et al.). 40% of the students and 45% of the faculty participants have been women and members of underrepresented groups. More than 90% of student alumni are attending graduate school and/or pursuing a career in STEM. 42% of those pursuing graduate degrees in Physics or Astronomy are women.In this presentation, we summarize the UAT program and the current research efforts of UAT members based on Arecibo science, including multiwavelength followup observations of ALFALFA sources, the UAT Collaborative Groups Project, the Survey of HI in Extremely Low-mass Dwarfs (SHIELD), and the Arecibo Pisces-Perseus Supercluster Survey (APPSS). This work has been supported by NSF grants AST-0724918/0902211, AST-075267/0903394, AST-0725380, AST-121105, and AST-1637339.

  6. What Can Human Geography Offer Climate Change Modelling?

    DEFF Research Database (Denmark)

    Grindsted, Thomas Skou

    2014-01-01

    The discipline of Geography may be one of the most prominent and oldest disciplines in the conceptualization of human–environment interactions that integrates elements from both natural and social sciences. Yet, much research on society–environment interactions on climate change reduces human...... conceptual modelling of climate change adaption and mitigation. In other words, geographical representations do matter. In the following we will first reflect upon what I shall call spatio-temporal tides and waves of the human environment theme to examine the methodological grounds on which climate change...

  7. At Your Request(®) room service dining improves patient satisfaction, maintains nutritional status, and offers opportunities to improve intake.

    Science.gov (United States)

    Doorduijn, Astrid S; van Gameren, Yvonne; Vasse, Emmelyne; de Roos, Nicole M

    2016-10-01

    Malnutrition in hospitals may be combatted by improving the meal service. To evaluate whether At Your Request(®), a meal service concept by Sodexo with a restaurant style menu card and room service, improved patient satisfaction, nutritional status, and food intake compared to the traditional 3-meals per day service. We prospectively collected data in Hospital Gelderse Vallei (Ede, the Netherlands) before (2011/2012; n = 168, age 63 ± 15 y) and after (2013/2014; n = 169, 66 ± 15 y) implementing At Your Request(®). Patient satisfaction increased after implementing At Your Request(®) from 7.5 to 8.1 (scale 1-10) and from 124.5 to 132.9 points on a nutrition-related quality of life questionnaire (p concept that helps patients to maintain nutritional status. The concept offers options for improving the intake of specific nutrients and foods, which should be evaluated in further studies. Copyright © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  8. Recent advances in understanding the genetic resources of sheep breeds locally-adapted to the UK uplands : opportunities they offer for sustainable productivity.

    Directory of Open Access Journals (Sweden)

    Dianna eBowles

    2015-02-01

    Full Text Available Locally adapted breeds of livestock are of considerable interest since they represent potential reservoirs of adaptive fitness traits that may contribute to the future of sustainable productivity in a changing climate.Recent research, involving three hill sheep breeds geographically concentrated in the northern uplands of the UK has revealed the extent of their genetic diversity from one another and from other breeds. Results from the use of SNPs, microsatellites and retrovirus insertions are reviewed in the context of related studies on sheep breeds world-wide to highlight opportunities offered by the genetic resources of locally adapted hill breeds. One opportunity concerns reduced susceptibility to Maedi-Visna, a lentivirus with massive impacts on sheep health and productivity globally. In contrast to many mainstream breeds used in farming, each of the hill breeds analysed are likely to be far less susceptible to the disease threat. A different opportunity, relating specifically to the Herdwick breed, is the extent to which the genome of the breed has retained primitive features, no longer present in other mainland breeds of sheep in the UK and offering a new route for discovering unique genetic traits of use to agriculture.

  9. The bacterial skin microbiome in psoriatic arthritis, an unexplored link in pathogenesis: challenges and opportunities offered by recent technological advances.

    Science.gov (United States)

    Castelino, Madhura; Eyre, Stephen; Upton, Mathew; Ho, Pauline; Barton, Anne

    2014-05-01

    The resident microbial community, harboured by humans in sites such as the skin and gastrointestinal tract, is enormous, representing a candidate environmental factor affecting susceptibility to complex diseases, where both genetic and environmental risk factors are important. The potential of microorganisms to influence the human immune system is considerable, given their ubiquity. The impact of the host-gene-microbe interaction on the maintenance of health and the development of disease has not yet been assessed robustly in chronic inflammatory conditions. PsA represents a model inflammatory disease to explore the role of the microbiome because skin involvement and overlap with IBD implicates both the skin and gastrointestinal tract as sources of microbial triggers for PsA. In parallel with genetic studies, characterization of the host microbiota may benefit our understanding of the microbial contribution to disease pathogenesis-knowledge that may eventually inform the development of novel therapeutics.

  10. Prescriptive Statements and Educational Practice: What Can Structural Equation Modeling (SEM) Offer?

    Science.gov (United States)

    Martin, Andrew J.

    2011-01-01

    Longitudinal structural equation modeling (SEM) can be a basis for making prescriptive statements on educational practice and offers yields over "traditional" statistical techniques under the general linear model. The extent to which prescriptive statements can be made will rely on the appropriate accommodation of key elements of research design,…

  11. An Inventory Model with Finite Replenishment Rate, Trade Credit Policy and Price-Discount Offer

    Directory of Open Access Journals (Sweden)

    Biswajit Sarkar

    2013-01-01

    Full Text Available When some suppliers offer trade credit periods and price discounts to retailers in order to increase the demand of their products, retailers have to face different types of discount offers and credits within which they have to take a decision which is the best offer for them to make more profit. The retailers try to buy perfect-quality items at a reasonable price, and also they try to invest returns obtained by selling those items in such a manner that their business is not hampered. In this point of view, we consider an economic order quantity (EOQ model for various types of time-dependent demand when delay in payment and price discount are permitted by suppliers to retailers. The models of various demand patterns are discussed analytically. Some numerical examples and graphical representations are considered to illustrate the model.

  12. Cameroon mid-level providers offer a promising public health dentistry model

    Directory of Open Access Journals (Sweden)

    Achembong Leo

    2012-11-01

    Full Text Available Background Oral health services are inadequate and unevenly distributed in many developing countries, particularly those in sub-Saharan Africa. Rural areas in these countries and poorer sections of the population in urban areas often do not have access to oral health services mainly because of a significant shortage of dentists and the high costs of care. We reviewed Cameroon’s experience with deploying a mid-level cadre of oral health professionals and the feasibility of establishing a more formal and predictable role for these health workers. We anticipate that a task-shifting approach in the provision of dental care will significantly improve the uneven distribution of oral health services particularly in the rural areas of Cameroon, which is currently served by only 3% of the total number of dentists. Methods The setting of this study was the Cameroon Baptist Convention Health Board (BCHB, which has four dentists and 42 mid-level providers. De-identified data were collected manually from the registries of 10 Baptist Convention clinics located in six of Cameroon’s 10 regions and then entered into an Excel format before importing into STATA. A retrospective abstraction of all entries for patient visits starting October 2010, and going back in time until 1500 visits were extracted from each clinic. Results This study showed that mid-level providers in BCHB clinics are offering a full scope of dental work across the 10 clinics, with the exception of treatment for major facial injuries. Mid-level providers alone performed 93.5% of all extractions, 87.5% of all fillings, 96.5% of all root canals, 97.5% of all cleanings, and 98.1% of all dentures. The dentists also typically played a teaching role in training the mid-level providers. Conclusions The Ministry of Health in Cameroon has an opportunity to learn from the BCHB model to expand access to oral health care across the country. This study shows the benefits of using a simple, workable, low

  13. Challenges and Opportunities in Analysing Students Modelling

    Science.gov (United States)

    Blanco-Anaya, Paloma; Justi, Rosária; Díaz de Bustamante, Joaquín

    2017-01-01

    Modelling-based teaching activities have been designed and analysed from distinct theoretical perspectives. In this paper, we use one of them--the model of modelling diagram (MMD)--as an analytical tool in a regular classroom context. This paper examines the challenges that arise when the MMD is used as an analytical tool to characterise the…

  14. Offering model for a virtual power plant based on stochastic programming

    DEFF Research Database (Denmark)

    PandŽić, Hrvoje; Morales González, Juan Miguel; Conejo, Antonio J.

    2013-01-01

    electricity in both the day-ahead and the balancing markets seeking to maximize its expected profit. Such model is mathematically rigorous, yet computationally efficient.The offering problem is cast as a two-stage stochastic mixed-integer linear programming model which maximizes the virtual power plant......A virtual power plant aggregates various local production/consumption units that act in the market as a single entity. This paper considers a virtual power plant consisting of an intermittent source, a storage facility, and a dispatchable power plant. The virtual power plant sells and purchases...

  15. Opportunities of probabilistic flood loss models

    Science.gov (United States)

    Schröter, Kai; Kreibich, Heidi; Lüdtke, Stefan; Vogel, Kristin; Merz, Bruno

    2016-04-01

    Oftentimes, traditional uni-variate damage models as for instance depth-damage curves fail to reproduce the variability of observed flood damage. However, reliable flood damage models are a prerequisite for the practical usefulness of the model results. Innovative multi-variate probabilistic modelling approaches are promising to capture and quantify the uncertainty involved and thus to improve the basis for decision making. In this study we compare the predictive capability of two probabilistic modelling approaches, namely Bagging Decision Trees and Bayesian Networks and traditional stage damage functions. For model evaluation we use empirical damage data which are available from computer aided telephone interviews that were respectively compiled after the floods in 2002, 2005, 2006 and 2013 in the Elbe and Danube catchments in Germany. We carry out a split sample test by sub-setting the damage records. One sub-set is used to derive the models and the remaining records are used to evaluate the predictive performance of the model. Further we stratify the sample according to catchments which allows studying model performance in a spatial transfer context. Flood damage estimation is carried out on the scale of the individual buildings in terms of relative damage. The predictive performance of the models is assessed in terms of systematic deviations (mean bias), precision (mean absolute error) as well as in terms of sharpness of the predictions the reliability which is represented by the proportion of the number of observations that fall within the 95-quantile and 5-quantile predictive interval. The comparison of the uni-variable Stage damage function and the multivariable model approach emphasises the importance to quantify predictive uncertainty. With each explanatory variable, the multi-variable model reveals an additional source of uncertainty. However, the predictive performance in terms of precision (mbe), accuracy (mae) and reliability (HR) is clearly improved

  16. Traffic Congestion Model: Challenges and Opportunities

    Science.gov (United States)

    Enjat Munajat, M. D.; Munir, Rinaldi; Widyantoro, Dwi H.

    2017-01-01

    This paper discusses models to detect traffic congestion using two approaches: road detection and moving object detection. There are two methods proposed to detect roads and moving objects. The methods involve the detection of both moving and non-moving objects. The system presented in this paper is able to detect roads as well as moving objects. However, further development is needed to detect extreme road curves. The system presented in this paper is relatively inexpensive since it only uses one camera and capable of capturing satisfactorily detailed images.

  17. Classical Biological Control of Invasive Legacy Crop Pests: New Technologies Offer Opportunities to Revisit Old Pest Problems in Perennial Tree Crops

    Directory of Open Access Journals (Sweden)

    Mark S. Hoddle

    2014-12-01

    Full Text Available Advances in scientific disciplines that support classical biological control have provided “new tools” that could have important applications for biocontrol programs for some long-established invasive arthropod pests. We suggest that these previously unavailable tools should be used in biological control programs targeting “legacy pests”, even if they have been targets of previously unsuccessful biocontrol projects. Examples of “new tools” include molecular analyses to verify species identities and likely geographic area of origin, climate matching and ecological niche modeling, preservation of natural enemy genetic diversity in quarantine, the use of theory from invasion biology to maximize establishment likelihoods for natural enemies, and improved understanding of the interactions between natural enemy and target pest microbiomes. This review suggests that opportunities exist for revisiting old pest problems and funding research programs using “new tools” for developing biological control programs for “legacy pests” could provide permanent suppression of some seemingly intractable pest problems. As a case study, we use citricola scale, Coccus pseudomagnoliarum, an invasive legacy pest of California citrus, to demonstrate the potential of new tools to support a new classical biological control program targeting this insect.

  18. Classical Biological Control of Invasive Legacy Crop Pests: New Technologies Offer Opportunities to Revisit Old Pest Problems in Perennial Tree Crops.

    Science.gov (United States)

    Hoddle, Mark S; Warner, Keith; Steggall, John; Jetter, Karen M

    2014-12-23

    Advances in scientific disciplines that support classical biological control have provided "new tools" that could have important applications for biocontrol programs for some long-established invasive arthropod pests. We suggest that these previously unavailable tools should be used in biological control programs targeting "legacy pests", even if they have been targets of previously unsuccessful biocontrol projects. Examples of "new tools" include molecular analyses to verify species identities and likely geographic area of origin, climate matching and ecological niche modeling, preservation of natural enemy genetic diversity in quarantine, the use of theory from invasion biology to maximize establishment likelihoods for natural enemies, and improved understanding of the interactions between natural enemy and target pest microbiomes. This review suggests that opportunities exist for revisiting old pest problems and funding research programs using "new tools" for developing biological control programs for "legacy pests" could provide permanent suppression of some seemingly intractable pest problems. As a case study, we use citricola scale, Coccus pseudomagnoliarum, an invasive legacy pest of California citrus, to demonstrate the potential of new tools to support a new classical biological control program targeting this insect.

  19. Offering solutions of sustainable urban tourism by the use of SWOT model, case study Isfahan city

    Directory of Open Access Journals (Sweden)

    Monireh Roustazadeh Sheikh Yousefi

    2014-08-01

    Full Text Available Tourism phenomenon has been spread world wildtoday. It's because of technological innovation development and overallcapitalism expansion in current age. Tourism in this situation has caused humanbeing relocation and mobility and in worldwide level, has created concept ofrelationship with other cultures in different locations, as socio-geographicalphenomenon. In this case cities includes important scientific, recreational,sport, shrine, historical, culture, medical, centers, etc., in addition to thiscases, also utilities natural attraction, etc., can play vole as touristic cityin the center of the country. in this research discursive- analysis method hasbeen used for collecting data and proceed to identify tourism potentials ,abilities, limitations and inadequacy of Isfahan by documental and librarydeliberations and field studies, SWOT model has been used for analyzing data.Then, offering solutions for sustainable urban development and eventuallymovement toward tourism development have been emphasized on.

  20. Special Offers

    CERN Multimedia

    Association du personnel

    2011-01-01

    Walibi Rhône-Alpes is open until 31 October. Reduced prices for children and adults at this French attraction park in Les Avenières. For more information about all these offers, please consult our web site: http://association.web.cern.ch/association/en/OtherActivities/Offers.html

  1. Creating opportunities to influence self-efficacy through modeling instruction

    Science.gov (United States)

    Sawtelle, Vashti; Brewe, Eric; Goertzen, Renee Michelle; Kramer, Laird H.

    2012-02-01

    In this paper we present an initial analysis connecting key elements of Modeling Instruction (MI) to self-efficacy experience opportunities. Previously, we demonstrated that MI has positive effects on self-efficacy when compared with traditional Lecture instruction [1]. We also found a particularly strong positive effect on the social persuasion source of self-efficacy for women in the MI class. Our current study seeks to understand through what mechanisms MI influences self-efficacy. We demonstrate this connection through an in-depth analysis of video chosen to exemplify Modeling techniques used in a problem-solving episode by three female participants enrolled in a MI introductory physics class. We provide a rich and descriptive analysis of the self-efficacy experiences opportunities within this context and discuss how these opportunities provide a potential explanation of how MI influences self-efficacy.

  2. Special offers

    CERN Multimedia

    Staff Association

    2011-01-01

    Are you a member of the Staff Association? Did you know that as a member you can benefit from the following special offers: BCGE (Banque Cantonale de Genève): personalized banking solutions with preferential conditions. TPG: reduced rates on annual transport passes for active and retired staff. Aquaparc: reduced ticket prices for children and adults at this Swiss waterpark in Le Bouveret. FNAC: 5% reduction on FNAC vouchers. For more information about all these offers, please consult our web site: http://association.web.cern.ch/association/en/OtherActivities/Offers.html

  3. Special Offers

    CERN Multimedia

    Association du personnel

    2011-01-01

    Are you a member of the Staff Association? Did you know that as a member you can benefit from the following special offers: BCGE (Banque Cantonale de Genève): personalized banking solutions with preferential conditions. TPG: reduced rates on annual transport passes for active and retired staff. Aquaparc: reduced ticket prices for children and adults at this Swiss waterpark in Le Bouveret. Walibi: reduced prices for children and adults at this French attraction park in Les Avenières. FNAC: 5% reduction on FNAC vouchers. For more information about all these offers, please consult our web site: http://association.web.cern.ch/association/en/OtherActivities/Offers.html

  4. Projected Statewide Impact of "Opportunity Culture" School Models

    Science.gov (United States)

    Holly, Christen; Dean, Stephanie; Hassel, Emily Ayscue; Hassel, Bryan C.

    2014-01-01

    This brief estimates the impact of a statewide implementation of Opportunity Culture models, using North Carolina as an example. Impacts estimated include student learning outcomes, gross state product, teacher pay, and other career characteristics, and state income tax revenue. Estimates indicate the potential for a statewide transition to…

  5. Offers INTERSOCCER

    CERN Document Server

    Staff Association

    2014-01-01

      Summer Football camps   New offer to the members of the Staff Association – INTERSOCCER: 12% discount on summer football camps and courses for children (bilingual) so do not hesitate anymore!    

  6. A Dynamic Web Page Prediction Model Based on Access Patterns to Offer Better User Latency

    CERN Document Server

    Mukhopadhyay, Debajyoti; Saha, Dwaipayan; Kim, Young-Chon

    2011-01-01

    The growth of the World Wide Web has emphasized the need for improvement in user latency. One of the techniques that are used for improving user latency is Caching and another is Web Prefetching. Approaches that bank solely on caching offer limited performance improvement because it is difficult for caching to handle the large number of increasingly diverse files. Studies have been conducted on prefetching models based on decision trees, Markov chains, and path analysis. However, the increased uses of dynamic pages, frequent changes in site structure and user access patterns have limited the efficacy of these static techniques. In this paper, we have proposed a methodology to cluster related pages into different categories based on the access patterns. Additionally we use page ranking to build up our prediction model at the initial stages when users haven't already started sending requests. This way we have tried to overcome the problems of maintaining huge databases which is needed in case of log based techn...

  7. Special Offers

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    Association du personnel

    2011-01-01

    Are you a member of the Staff Association? Did you know that as a member you can benefit from the following special offers: BCGE (Banque Cantonale de Genève): personalized banking solutions with preferential conditions.     TPG: reduced rates on annual transport passes for active and retired staff.     Aquaparc: reduced ticket prices for children and adults at this Swiss waterpark in Le Bouveret.     Walibi: reduced prices for children and adults at this French attraction park in Les Avenières.       FNAC: 5% reduction on FNAC vouchers.       For more information about all these offers, please consult our web site: http://association.web.cern.ch/association/en/OtherActivities/Offers.html

  8. Special Offers

    CERN Multimedia

    Staff Association

    2011-01-01

    Are you a member of the Staff Association? Did you know that as a member you can benefit from the following special offers: BCGE (Banque Cantonale de Genève): personalized banking solutions with preferential conditions.     TPG: reduced rates on annual transport passes for all active and retired staff.     Aquaparc: reduced ticket prices for children and adults at this Swiss waterpark in Le Bouveret.     Walibi: reduced prices for children and adults at this French attraction park in Les Avenières.       FNAC: 5% reduction on FNAC vouchers.       For more information about all these offers, please consult our web site: http://association.web.cern.ch/association/en/OtherActivities/Offers.html

  9. A Strategic Buffet: What The Brahimi Report Says About UN Peace Operations And The Opportunities It Offers To The Regional U.S. Unified Commanders

    Science.gov (United States)

    2007-11-02

    enhancing international interoperability by writing the much needed doctrine for UN peace operations. Given the feast of opportunities for peacetime...Conflict. New York: Simon & Schuster, 2000. Shelton, Henry H. "From the Chairman." Harvard International Review. Vol XX, No. 1. Winter 1997/1998. Simma...Commander’s Handbook on Peace Operations. Monroe, VA: 1997. U.S. President. White House . A National Security Strategy For A Global Age. Washington, D.C

  10. Missed opportunities to offer HIV tests to high-risk groups during general practitioners' STI-related consultations: an observational study

    NARCIS (Netherlands)

    Joore, I.K.; Reukers, D.F.M.; Donker, G.A.; Sighem, A.I. van; Coul, E.L. Op de; Prins, J.M.; Geerlings, S.E.; Barth, R.E.; Bergen, J.E. van; Broek, I.V. van den

    2016-01-01

    OBJECTIVES: Prior research has shown that Dutch general practitioners (GPs) do not always offer HIV testing and the number of undiagnosed HIV patients remains high. We aimed to further investigate the frequency and reasons for (not) testing for HIV and the contribution of GPs to the diagnosis of HIV

  11. Missed opportunities to offer HIV tests to high-risk groups during general practitioners’ STI-related consultations: an observational study.

    NARCIS (Netherlands)

    Joore, I.K.; Reukers, D.F.M.; Donker, G.A.; Sighem, A.I. van; Coul, E.L.M. Op de; Prins, J.M.; Geerlings, S.E.; Barth, S.R.E.; Bergen, J.E.A.M. van; Broek, I.V.F. van den

    2016-01-01

    Objectives: Prior research has shown that Dutch general practitioners (GPs) do not always offer HIV testing and the number of undiagnosed HIV patients remains high. We aimed to further investigate the frequency and reasons for (not) testing for HIV and the contribution of GPs to the diagnosis of HIV

  12. Missed opportunities to offer HIV tests to high-risk groups during general practitioners’ STI-related consultations: an observational study.

    NARCIS (Netherlands)

    Joore, I.K.; Reukers, D.F.M.; Donker, G.A.; Sighem, A.I. van; Coul, E.L.M. Op de; Prins, J.M.; Geerlings, S.E.; Barth, S.R.E.; Bergen, J.E.A.M. van; Broek, I.V.F. van den

    2016-01-01

    Objectives: Prior research has shown that Dutch general practitioners (GPs) do not always offer HIV testing and the number of undiagnosed HIV patients remains high. We aimed to further investigate the frequency and reasons for (not) testing for HIV and the contribution of GPs to the diagnosis of HIV

  13. Special offer

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    2010-01-01

    Special offer for members of the Staff Association and their families 10% reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Plus 20% reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * next “vente privée” from 24th to 29th May 2010  

  14. Special offer

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    SPECIAL OFFER FOR OUR MEMBERS Tarif unique Adulte/Enfant Entrée Zone terrestre 19 euros instead of 23 euros Entrée “Zone terrestre + aquatique” 24 euros instead of 31 euros Free for children under 3, with limited access to the attractions. Walibi Rhône-Alpes is open daily from 22 June to 31 August, and every week end from 3 September until 31 October. Closing of the “zone aquatique” 11 September.

  15. Special offer

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    Staff Association

    2011-01-01

    SPECIAL OFFER FOR OUR MEMBERS Tarif unique Adulte/Enfant Entrée Zone terrestre 19 euros instead of 23 euros Entrée “Zone terrestre + aquatique” 24 euros instead of 31 euros Free for children under 3, with limited access to the attractions. Walibi Rhône-Alpes is open daily from 22 June to 31 August, and every week end from 3 September until 31 October. Closing of the “zone aquatique” 11 September.

  16. Model Based Mission Assurance: Emerging Opportunities for Robotic Systems

    Science.gov (United States)

    Evans, John W.; DiVenti, Tony

    2016-01-01

    The emergence of Model Based Systems Engineering (MBSE) in a Model Based Engineering framework has created new opportunities to improve effectiveness and efficiencies across the assurance functions. The MBSE environment supports not only system architecture development, but provides for support of Systems Safety, Reliability and Risk Analysis concurrently in the same framework. Linking to detailed design will further improve assurance capabilities to support failures avoidance and mitigation in flight systems. This also is leading new assurance functions including model assurance and management of uncertainty in the modeling environment. Further, the assurance cases, a structured hierarchal argument or model, are emerging as a basis for supporting a comprehensive viewpoint in which to support Model Based Mission Assurance (MBMA).

  17. A Newsvendor Model with Initial Inventory and Two Salvage Opportunities

    Directory of Open Access Journals (Sweden)

    Ali Cheaitou

    2011-06-01

    Full Text Available In this paper, we develop an extension of the newsvendor model with initial inventory. In addition to the usual quantity ordered at the beginning of the horizon and the usual quantity salvaged at the end of the horizon, we introduce a new decision variable: a salvage opportunity at the beginning of the horizon, which might be used in the case of high initial inventory level. We develop the expression of the optimal policy for this extended model, for a general demand distribution. The structure of this optimal policy is particular and is characterized by two threshold levels. Some managerial insights are given via numerical examples.

  18. Offering an Anatomy and Physiology Course through a High School-University Partnership: The Minnesota Model

    Science.gov (United States)

    Jensen, Murray; Mattheis, Allison; Loyle, Anne

    2013-01-01

    This article describes a one-semester anatomy and physiology course that is currently offered through the concurrent enrollment program at the University of Minnesota. The article explains how high school teachers are prepared to teach the course and describes efforts to promote program quality, student inquiry, and experiential learning.…

  19. Seasonal forecasting and health impact models: challenges and opportunities.

    Science.gov (United States)

    Ballester, Joan; Lowe, Rachel; Diggle, Peter J; Rodó, Xavier

    2016-10-01

    After several decades of intensive research, steady improvements in understanding and modeling the climate system have led to the development of the first generation of operational health early warning systems in the era of climate services. These schemes are based on collaborations across scientific disciplines, bringing together real-time climate and health data collection, state-of-the-art seasonal climate predictions, epidemiological impact models based on historical data, and an understanding of end user and stakeholder needs. In this review, we discuss the challenges and opportunities of this complex, multidisciplinary collaboration, with a focus on the factors limiting seasonal forecasting as a source of predictability for climate impact models. © 2016 New York Academy of Sciences.

  20. Challenges and opportunities for integrating lake ecosystem modelling approaches

    Science.gov (United States)

    Mooij, Wolf M.; Trolle, Dennis; Jeppesen, Erik; Arhonditsis, George; Belolipetsky, Pavel V.; Chitamwebwa, Deonatus B.R.; Degermendzhy, Andrey G.; DeAngelis, Donald L.; Domis, Lisette N. De Senerpont; Downing, Andrea S.; Elliott, J. Alex; Ruberto, Carlos Ruberto; Gaedke, Ursula; Genova, Svetlana N.; Gulati, Ramesh D.; Hakanson, Lars; Hamilton, David P.; Hipsey, Matthew R.; Hoen, Jochem 't; Hulsmann, Stephan; Los, F. Hans; Makler-Pick, Vardit; Petzoldt, Thomas; Prokopkin, Igor G.; Rinke, Karsten; Schep, Sebastiaan A.; Tominaga, Koji; Van Dam, Anne A.; Van Nes, Egbert H.; Wells, Scott A.; Janse, Jan H.

    2010-01-01

    A large number and wide variety of lake ecosystem models have been developed and published during the past four decades. We identify two challenges for making further progress in this field. One such challenge is to avoid developing more models largely following the concept of others ('reinventing the wheel'). The other challenge is to avoid focusing on only one type of model, while ignoring new and diverse approaches that have become available ('having tunnel vision'). In this paper, we aim at improving the awareness of existing models and knowledge of concurrent approaches in lake ecosystem modelling, without covering all possible model tools and avenues. First, we present a broad variety of modelling approaches. To illustrate these approaches, we give brief descriptions of rather arbitrarily selected sets of specific models. We deal with static models (steady state and regression models), complex dynamic models (CAEDYM, CE-QUAL-W2, Delft 3D-ECO, LakeMab, LakeWeb, MyLake, PCLake, PROTECH, SALMO), structurally dynamic models and minimal dynamic models. We also discuss a group of approaches that could all be classified as individual based: super-individual models (Piscator, Charisma), physiologically structured models, stage-structured models and trait-based models. We briefly mention genetic algorithms, neural networks, Kalman filters and fuzzy logic. Thereafter, we zoom in, as an in-depth example, on the multi-decadal development and application of the lake ecosystem model PCLake and related models (PCLake Metamodel, Lake Shira Model, IPH-TRIM3D-PCLake). In the discussion, we argue that while the historical development of each approach and model is understandable given its 'leading principle', there are many opportunities for combining approaches. We take the point of view that a single 'right' approach does not exist and should not be strived for. Instead, multiple modelling approaches, applied concurrently to a given problem, can help develop an integrative

  1. Growth Opportunities,Scales of Seasoned Equity Offering and Share Price Effects of Listed Companies%上市公司增长机会、增发数量与股价反应

    Institute of Scientific and Technical Information of China (English)

    黎精明; 赵燕

    2012-01-01

    Based on the examples of the A-share listed companies that succeeded in seasoned equity offering from 2007 to 2009,the paper made an empirical analysis of the relationship between the scales of seasoned equity offering and the share price effects.The research results showed that the scale of seasoned equity offering depended on its growth opportunities,in other words,the greater the growth opportunities,the higher ratio of the number of seasoned equity offering to the total equity of the pre-offering.The paper also indicated that the stock market would make significant negative reaction to the over-issuing of listed companies,and only weak evidence proved that cautious re-offering would lead the stock price to drop.In addition,the paper also showed that public re-offering companies were more inclined to over-issue than the directed re-offering companies,and their stock prices tend to change radically.%以2007年至2009年成功增发的A股上市公司为样本,对我国上市公司增发数量与股价变动的相互关系进行研究,结果表明:上市公司的增发数量内生于其增长机会,增长机会越大的公司增发数量占发行前总股本的比率也越高;股市对上市公司的过度增发会做出显著的负面反应,但仅有微弱的证据表明谨慎增发会导致股价下跌;公开增发的上市公司较之于定向增发的上市公司具有更多的过度增发倾向,且股价反应也更剧烈。

  2. New Insights Offered by a Computational Model of Deep Brain Stimulation

    DEFF Research Database (Denmark)

    Modolo, J.; Mosekilde, Erik; Beuter, A.

    2007-01-01

    elucidated. The paper starts with a brief review on the use of DBS to treat PD symptoms. The second section introduces a computational model based on the population density approach and the Izhikevich neuron model. We explain why this model is appropriate for investigating macroscopic network effects...

  3. Predicting Behavior from Normative Influences: What Insights Can the Fishbein Model Offer?

    Science.gov (United States)

    Walster, Dian E.

    The Fishbein Model is an attitude behavior consistency model which is used in both laboratory and field settings for predicting and understanding attitudinal and normative influences on behavior. This paper examines controversy surrounding the Fishbein Model's normative component in the context of a study of library and information science (LIS)…

  4. Opportunities Offered by Chiral η6-Arene/N-Arylsulfonyl-diamine-RuII Catalysts in the Asymmetric Transfer Hydrogenation of Ketones and Imines

    Directory of Open Access Journals (Sweden)

    Libor Červený

    2011-06-01

    Full Text Available Methods for the asymmetric transfer hydrogenation (ATH of ketones and imines are still being intensively studied and developed. Of foremost interest is the use of Noyori’s [RuCl(η6-arene(N-TsDPEN] complexes in the presence of a hydrogen donor (i-PrOH, formic acid. These complexes have found numerous practical applications and have been extensively modified. The resulting derivatives have been heterogenized, used in ATH in water or ionic liquids and even some attempts have been made to approach the properties of biocatalysts. Therefore, an appropriate modification of the catalyst that suits the specific requirements for the reaction conditions is very often readily available. The mechanism of the reaction has also been explored to a great extent. Model substrates, acetophenone (a ketone and 6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline (an imine, are both reduced by this Ru catalytic system with almost perfect selectivity. However, in each case the major product is a different enantiomer (S- for an alcohol, R- for an amine when the S,S-catalyst is used, which demanded an in-depth mechanistic investigation. Full-scale molecular modelling of this system enabled us to visualize the plausible 3D structures of the transition states, allowing the proposition of a viable explanation of previous experimental findings.

  5. Network models of frugivory and seed dispersal: Challenges and opportunities

    Science.gov (United States)

    Carlo, Tomás A.; Yang, Suann

    2011-11-01

    Network analyses have emerged as a new tool to study frugivory and seed dispersal (FSD) mutualisms because networks can model and simplify the complexity of multiple community-wide species interactions. Moreover, network theory suggests that structural properties, such as the presence of highly generalist species, are linked to the stability of mutualistic communities. However, we still lack empirical validation of network model predictions. Here we outline new research avenues to connect network models to FSD processes, and illustrate the challenges and opportunities of this tool with a field study. We hypothesized that generalist frugivores would be important for forest stability by dispersing seeds into deforested areas and initiating reforestation. We then constructed a network of plant-frugivore interactions using published data and identified the most generalist frugivores. To test the importance of generalists we measured: 1) the frequency with which frugivores moved between pasture and forest, 2) the bird-generated seed rain under perches in the pasture, and 3) the perching frequency of birds above seed traps. The generalist frugivores in the forest network were not important for seed dispersal into pastures, and thus for forest recovery, because the forest network excluded habitat heterogeneities, frugivore behavior, and movements. More research is needed to develop ways to incorporate relevant FSD processes into network models in order for these models to be more useful to community ecology and conservation. The network framework can serve to spark and renew interest in FSD and further our understanding of plant-animal communities.

  6. New macrophage models of Gaucher disease offer new tools for drug development.

    Science.gov (United States)

    Borger, Daniel K; Sidransky, Ellen; Aflaki, Elma

    Gaucher disease is an inherited enzyme deficiency resulting in the lysosomal accumulation of specific glycolipids in macrophages and, in some cases, neurons. While current treatments are effective at reducing this glycolipid storage in macrophages, they are expensive and ineffective in treating neurological manifestations of the disease, driving the search for novel therapeutics. Moreover, mutations in GBA1, the gene implicated in Gaucher disease, are an important risk factor for the development of Parkinson disease and related disorders, an association that has further heightened interest in Gaucher disease research. However, the development of therapeutic strategies has been hampered by a shortage of appropriate cellular models of Gaucher disease. We have generated two novel macrophage models of Gaucher disease, one through the differentiation of peripheral blood monocytes from patients with Gaucher disease and the other through the differentiation of induced pluripotent stem cells derived from patient fibroblasts. Both disease models demonstrate similar cellular phenotypes and exhibit extensive glycolipid storage when exposed to exogenous lipid sources such as erythrocyte membranes. Furthermore, we have used these models to confirm the efficacy of a novel small molecule in clearing glycolipid storage and restoring normal macrophage function. These results demonstrate the usefulness of these models in exploring new therapeutics for Gaucher disease and related disorders.

  7. Tramp Ship Routing and Scheduling - Models, Methods and Opportunities

    DEFF Research Database (Denmark)

    Vilhelmsen, Charlotte; Larsen, Jesper; Lusby, Richard Martin

    and scheduling. This includes a review on existing literature, modelling approaches, solution methods as well as an analysis of the current status and future opportunities of research within tramp ship routing and scheduling. We argue that rather than developing new solution methods for the basic routing...... to mergers, pooling, and collaboration efforts between shipping companies, the fleet sizes have grown to a point where manual planning is no longer adequate in a market with tough competition and low freight rates. The aim of this paper is to provide a comprehensive introduction to tramp ship routing...... and scheduling problem, focus should now be on extending this basic problem to include additional real-world complexities and develop suitable solution methods for those extensions. Such extensions will enable more tramp operators to benefit from the solution methods while simultaneously creating new...

  8. A Model of Sustainability for Professional Organizations: Using a Learning Management System to Offer Continuing Education

    Science.gov (United States)

    Sparrow, Gregory S.

    2017-01-01

    Professional membership organizations have long maintained their exposure and revenue stream through a variety of traditional avenues, most notably memberships, sponsored conferences, and professional journals. The synergy of this three-tiered model has depended on a certain enhanced status derived from membership benefits and proprietary…

  9. Variations in offer arrival rates in a stationary search model : a note

    NARCIS (Netherlands)

    Rao Sahib, Padma

    2001-01-01

    The standard search model predicts that the hazard and the expected accepted wage should be constant over an unemployment spell. This note shows that heterogeneity in job o®er arrival rates can generate declining hazards and declining accepted wages, results in conformity with the empirical evidence

  10. Integrative biological systems modeling:challenges and opportunities

    Institute of Scientific and Technical Information of China (English)

    Jialiang WU; Eberhard VOIT

    2009-01-01

    Most biological systems are by nature hybrids consist of interacting discrete and continuous components,which may even operate on different time scales. Therefore," it is desirable to establish modeling frameworks that are capable of combining deterministic and stochastic, discrete and continuous, as well as multi-timescale features. In the context of molecular systems biology, an example for the need of such a combination is the investigation of integrated biological pathways that contain gene regulatory, metabolic and signaling components, which may operate on different time scales and involve on-off switches as well as stochastic effects. The implementation of integrated hybrid systems is not trivial because most software is limited to one or the other of the dichotomies above. In this study, we first review the motivation for hybrid modeling. Secondly, by using the example of a toggle switch model, we illustrate a recently developed modeling framework that is based on the combination of biochemical systems theory (BST) and hybrid functional Petri nets (HFPN). Finally, we discuss remaining challenges and future opportunities.

  11. Dental Care Coverage and Use: Modeling Limitations and Opportunities

    Science.gov (United States)

    Moeller, John F.; Chen, Haiyan

    2014-01-01

    Objectives. We examined why older US adults without dental care coverage and use would have lower use rates if offered coverage than do those who currently have coverage. Methods. We used data from the 2008 Health and Retirement Study to estimate a multinomial logistic model to analyze the influence of personal characteristics in the grouping of older US adults into those with and those without dental care coverage and dental care use. Results. Compared with persons with no coverage and no dental care use, users of dental care with coverage were more likely to be younger, female, wealthier, college graduates, married, in excellent or very good health, and not missing all their permanent teeth. Conclusions. Providing dental care coverage to uninsured older US adults without use will not necessarily result in use rates similar to those with prior coverage and use. We have offered a model using modifiable factors that may help policy planners facilitate programs to increase dental care coverage uptake and use. PMID:24328635

  12. Advanced parallel programming models research and development opportunities.

    Energy Technology Data Exchange (ETDEWEB)

    Wen, Zhaofang.; Brightwell, Ronald Brian

    2004-07-01

    There is currently a large research and development effort within the high-performance computing community on advanced parallel programming models. This research can potentially have an impact on parallel applications, system software, and computing architectures in the next several years. Given Sandia's expertise and unique perspective in these areas, particularly on very large-scale systems, there are many areas in which Sandia can contribute to this effort. This technical report provides a survey of past and present parallel programming model research projects and provides a detailed description of the Partitioned Global Address Space (PGAS) programming model. The PGAS model may offer several improvements over the traditional distributed memory message passing model, which is the dominant model currently being used at Sandia. This technical report discusses these potential benefits and outlines specific areas where Sandia's expertise could contribute to current research activities. In particular, we describe several projects in the areas of high-performance networking, operating systems and parallel runtime systems, compilers, application development, and performance evaluation.

  13. New Science Opportunities Offered by MUSE

    Science.gov (United States)

    Bacon, R.; Bauer, S.; Brau-Nogué, S.; Caillier, P.; Capoani, L.; Carollo, M.; Contini, T.; Daguisé, E.; Delabre, B.; Dreizler, S.; Dubois, J. P.; Dupieux, M.; Dupin, J.; Emsellem, E.; Ferruit, P.; Francois, M.; Franx, M.; Gallou, G.; Gerssen, J.; Guiderdoni, B.; Hansali, G.; Hofmann, D.; Jarno, A.; Kelz, A.; Koehler, C.; Kollatschny, W.; Kosmalski, J.; Laurent, F.; Lilly, S.; Lizon, J.; Loupias, M.; Monstein, C.; Moultaka, J.; Nicklas, H.; Parés, L.; Pasquini, L.; Pecontal, A.; Pello, R.; Petit, C.; Manescau, A.; Reiss, R.; Remillieux, A.; Renault, E.; Roth, M.; Schaye, J.; Steinmetz, M.; Ströbele, S.; Stuik, R.; Weilbacher, P.; Wisotzki, L.; Wozniak, H.

    The Multi Unit Spectroscopic Explorer MUSE [MUSE public web site: http://muse.univ-lyon1.fr] is one of the second generation VLT instruments. MUSE is a wide-field optical integral field spectrograph operating in the visible wavelength range with improved spatial resolution. The MUSE Consortium consists of groups at Lyon (PI institute, CRAL), Gottingen (IAG), Potsdam (AIP), Leiden (NOVA), Toulouse (LATT), Zurich (ETH) and ESO. The project is currently in its final design phase. Manufacturing, assembly and integration will start after the Final Design Review which is foreseen for late 2008. The Preliminary acceptance in Europe is scheduled for mid 2011 and the instrument shall be in operation at Paranal in 2012.

  14. Multimillion-cell SAGD models, opportunity for detailed field analysis

    Energy Technology Data Exchange (ETDEWEB)

    Akram, F. [Schlumberger Canada Limited (Canada)

    2011-07-01

    In the heavy oil industry, steam assisted gravity drainage (SAGD) is a new thermal oil recovery process used to enhance oil recovery. However, operators have trouble reaching their objectives. A better understanding of reservoir response is necessary to reach the desired production rates. The aim of this paper is to present a new methodology for carrying out a reservoir simulation study. A multimillion-cell model was developed with realistic properties, structural complexity and heterogeneities; both full field and thermal simulations were conducted. Results showed that the computing technology thus developed offers greater accuracy in less time than is required when using conventional techniques. In addition, this methodology provides a higher degree of confidence in the results by bridging the gap between geology and engineering. The paper is a first step in producing a framework and the methodology presented herein will need to be further tested to confirm its benefits over conventional techniques.

  15. Specialty Payment Model Opportunities and Assessment: Oncology Simulation Report.

    Science.gov (United States)

    White, Chapin; Chan, Chris; Huckfeldt, Peter J; Kofner, Aaron; Mulcahy, Andrew W; Pollak, Julia; Popescu, Ioana; Timbie, Justin W; Hussey, Peter S

    2015-07-15

    This article describes the results of a simulation analysis of a payment model for specialty oncology services that is being developed for possible testing by the Center for Medicare and Medicaid Innovation at the Centers for Medicare & Medicaid Services (CMS). CMS asked MITRE and RAND to conduct simulation analyses to preview some of the possible impacts of the payment model and to inform design decisions related to the model. The simulation analysis used an episode-level dataset based on Medicare fee-for-service (FFS) claims for historical oncology episodes provided to Medicare FFS beneficiaries in 2010. Under the proposed model, participating practices would continue to receive FFS payments, would also receive per-beneficiary per-month care management payments for episodes lasting up to six months, and would be eligible for performance-based payments based on per-episode spending for attributed episodes relative to a per-episode spending target. The simulation offers several insights into the proposed payment model for oncology: (1) The care management payments used in the simulation analysis-$960 total per six-month episode-represent only 4 percent of projected average total spending per episode (around $27,000 in 2016), but they are large relative to the FFS revenues of participating oncology practices, which are projected to be around $2,000 per oncology episode. By themselves, the care management payments would increase physician practices' Medicare revenues by roughly 50 percent on average. This represents a substantial new outlay for the Medicare program and a substantial new source of revenues for oncology practices. (2) For the Medicare program to break even, participating oncology practices would have to reduce utilization and intensity by roughly 4 percent. (3) The break-even point can be reduced if the care management payments are reduced or if the performance-based payments are reduced.

  16. A Cross-Cultural Multi-agent Model of Opportunism in Trade

    Science.gov (United States)

    Hofstede, Gert Jan; Jonker, Catholijn M.; Verwaart, Tim

    According to transaction cost economics, contracts are always incomplete and offer opportunities to defect. Some level of trust is a sine qua non for trade. If the seller is better informed about product quality than the buyer, the buyer has to rely on information the seller provides or has to check the information by testing the product or tracing the supply chain processes, thus incurring extra transaction cost. An opportunistic seller who assumes the buyer to trust, may deliver a lower quality product than agreed upon. In human decisions to deceive and to show trust or distrust, issues like mutual expectations, shame, self-esteem, personality, and reputation are involved. These factors depend in part on traders' cultural background. This paper proposes an agent model of deceit and trust and describes a multi-agent simulation where trading agents are differentiated according to Hofstede's dimensions of national culture. Simulations of USA and Dutch trading situations are compared.

  17. Hurricane Loss Estimation Models: Opportunities for Improving the State of the Art.

    Science.gov (United States)

    Watson, Charles C., Jr.; Johnson, Mark E.

    2004-11-01

    The results of hurricane loss models are used regularly for multibillion dollar decisions in the insurance and financial services industries. These models are proprietary, and this “black box” nature hinders analysis. The proprietary models produce a wide range of results, often producing loss costs that differ by a ratio of three to one or more. In a study for the state of North Carolina, 324 combinations of loss models were analyzed, based on a combination of nine wind models, four surface friction models, and nine damage models drawn from the published literature in insurance, engineering, and meteorology. These combinations were tested against reported losses from Hurricanes Hugo and Andrew as reported by a major insurance company, as well as storm total losses for additional storms. Annual loss costs were then computed using these 324 combinations of models for both North Carolina and Florida, and compared with publicly available proprietary model results in Florida. The wide range of resulting loss costs for open, scientifically defensible models that perform well against observed losses mirrors the wide range of loss costs computed by the proprietary models currently in use. This outcome may be discouraging for governmental and corporate decision makers relying on this data for policy and investment guidance (due to the high variability across model results), but it also provides guidance for the efforts of future investigations to improve loss models. Although hurricane loss models are true multidisciplinary efforts, involving meteorology, engineering, statistics, and actuarial sciences, the field of meteorology offers the most promising opportunities for improvement of the state of the art.

  18. Offering a model for measuring service brand equity in the field of services : Testing and implementation in a virtual university.

    Directory of Open Access Journals (Sweden)

    Mehdi Giahchin

    2013-09-01

    Full Text Available Nowadays brand in businesses around the world including service provider companies, has a special role and a great importance.Brand equity is also a powerful tool in the marketing competitionthus managing the brand equity measurement is consequential. In this study we are trying to find some effective dimensions of the brand equity in the service firms and companies and after that we are going to offer some significant dimensions as a comprehensive model in education and e-learning at the level of higher education with considering different aspects of the products and services and also with considering the different aspects of service businesses on the services spectrumthen test the model statistically in a virtual university. Data collection was done through a questionnaire distributed to all 1031 faculty, students and staff of Mehralborz university and 300 responses were received. Sampling was done through random method and the sample volume based on Cochran's formula was 280 persons. Cronbach's alpha was used to ensure the reliability of the questionnaire and structural equation modeling was used to test the model. The consequences of statistical analysis showed that among the factors related to the customers, just experiences and psychological characteristics of faculty, students and staff are effective on the service brand equity of Mehralborz university.And also among the factors related to the brand awareness,just marketing activities are effective on the service brand equity of Mehralborz uiversity. Among the characteristics offered for the brand image,just symbolic characteristics and servicescape and also servise provider characteristics are effective on the service brand equity of Mehralborz university.

  19. Elite and Status Attainment Models of Inequality of Opportunity

    Science.gov (United States)

    Myles, John F.; Srensen, Aage B.

    1975-01-01

    With changes in method, analysis of the process of attainment of various occupations and sub-sets of occupations such as elites can bring about the desired comparability between elite and status attainment studies of equality of opportunity. (Author/AM)

  20. Toward an Integrative Understanding of Social Behavior: New Models and New Opportunities

    Science.gov (United States)

    Blumstein, Daniel T.; Ebensperger, Luis A.; Hayes, Loren D.; Vásquez, Rodrigo A.; Ahern, Todd H.; Burger, Joseph Robert; Dolezal, Adam G.; Dosmann, Andy; González-Mariscal, Gabriela; Harris, Breanna N.; Herrera, Emilio A.; Lacey, Eileen A.; Mateo, Jill; McGraw, Lisa A.; Olazábal, Daniel; Ramenofsky, Marilyn; Rubenstein, Dustin R.; Sakhai, Samuel A.; Saltzman, Wendy; Sainz-Borgo, Cristina; Soto-Gamboa, Mauricio; Stewart, Monica L.; Wey, Tina W.; Wingfield, John C.; Young, Larry J.

    2010-01-01

    Social interactions among conspecifics are a fundamental and adaptively significant component of the biology of numerous species. Such interactions give rise to group living as well as many of the complex forms of cooperation and conflict that occur within animal groups. Although previous conceptual models have focused on the ecological causes and fitness consequences of variation in social interactions, recent developments in endocrinology, neuroscience, and molecular genetics offer exciting opportunities to develop more integrated research programs that will facilitate new insights into the physiological causes and consequences of social variation. Here, we propose an integrative framework of social behavior that emphasizes relationships between ultimate-level function and proximate-level mechanism, thereby providing a foundation for exploring the full diversity of factors that underlie variation in social interactions, and ultimately sociality. In addition to identifying new model systems for the study of human psychopathologies, this framework provides a mechanistic basis for predicting how social behavior will change in response to environmental variation. We argue that the study of non-model organisms is essential for implementing this integrative model of social behavior because such species can be studied simultaneously in the lab and field, thereby allowing integration of rigorously controlled experimental manipulations with detailed observations of the ecological contexts in which interactions among conspecifics occur. PMID:20661457

  1. Towards an integrative understanding of social behavior: new models and new opportunities

    Directory of Open Access Journals (Sweden)

    Daniel T Blumstein

    2010-06-01

    Full Text Available Social interactions among conspecifics are a fundamental and adaptively significant component of the biology of numerous species. Such interactions give rise to group living as well as many of the complex forms of cooperation and conflict that occur within animal groups. Although previous conceptual models have focused on the ecological causes and fitness consequences of variation in social interactions, recent developments in endocrinology, neuroscience, and molecular genetics offer exciting opportunities to develop more integrated research programs that will facilitate new insights into the physiological causes and consequences of social variation. Here, we propose an integrative framework of social behavior that emphasizes relationships between ultimate-level function and proximate-level mechanism, thereby providing a foundation for exploring the full diversity of factors that underlie variation in social interactions, and ultimately sociality. In addition to identifying new model systems for the study of human psychopathologies, this framework provides a mechanistic basis for predicting how social behavior will change in response to environmental variation. We argue that the study of non-model organisms is essential for implementing this integrative model of social behavior because such species can be studied simultaneously in the lab and field, thereby allowing integration of rigorously controlled experimental manipulations with detailed observations of the ecological contexts in which interactions among conspecifics occur.

  2. Multi-level modeling of light-induced stomatal opening offers new insights into its regulation by drought.

    Science.gov (United States)

    Sun, Zhongyao; Jin, Xiaofen; Albert, Réka; Assmann, Sarah M

    2014-11-01

    Plant guard cells gate CO2 uptake and transpirational water loss through stomatal pores. As a result of decades of experimental investigation, there is an abundance of information on the involvement of specific proteins and secondary messengers in the regulation of stomatal movements and on the pairwise relationships between guard cell components. We constructed a multi-level dynamic model of guard cell signal transduction during light-induced stomatal opening and of the effect of the plant hormone abscisic acid (ABA) on this process. The model integrates into a coherent network the direct and indirect biological evidence regarding the regulation of seventy components implicated in stomatal opening. Analysis of this signal transduction network identified robust cross-talk between blue light and ABA, in which [Ca2+]c plays a key role, and indicated an absence of cross-talk between red light and ABA. The dynamic model captured more than 10(31) distinct states for the system and yielded outcomes that were in qualitative agreement with a wide variety of previous experimental results. We obtained novel model predictions by simulating single component knockout phenotypes. We found that under white light or blue light, over 60%, and under red light, over 90% of all simulated knockouts had similar opening responses as wild type, showing that the system is robust against single node loss. The model revealed an open question concerning the effect of ABA on red light-induced stomatal opening. We experimentally showed that ABA is able to inhibit red light-induced stomatal opening, and our model offers possible hypotheses for the underlying mechanism, which point to potential future experiments. Our modelling methodology combines simplicity and flexibility with dynamic richness, making it well suited for a wide class of biological regulatory systems.

  3. Social entrepreneurship in China: models, dynamics, challenges and opportunities

    OpenAIRE

    Kang, Mengqi

    2015-01-01

    Social entrepreneurship (SE) has been one of the most rapidly developing concepts among the academic world and also in society. Its significance could be partly explained by the fact that traditional non-profits and philanthropy have not been successful in solving some of the world's major social problems. However, there seems to be a void in China's position in the topic while in fact China seems to be a land full of opportunities for SE undertakings: while experiencing rapid economic develo...

  4. Developing a Creative-Cognitive Model of Entrepreneurial Alertness to Business Opportunities

    OpenAIRE

    Vesa Puhakka

    2011-01-01

    A creative-cognitive perspective is used in this study to explore alertness to business opportunities in order to develop a model of business opportunity recognition. It is assumed that the elements constituting this opportunity creation are entrepreneur¡¯s creative cognitive process, internal creative qualities, environmental conditions supporting or hindering creativity and interaction of these elements, and that they have a significant impact on the innovativeness of the business opportuni...

  5. Assets and tactics in a mating market: Economic models of negotiation offer insights into animal courtship dynamics on the lek

    Directory of Open Access Journals (Sweden)

    Gail L. PATRICELLI, Alan H. KRAKAUER, Richard MCELREATH

    2011-04-01

    Full Text Available Economists study negotiation as a series of events—partner choice, information gathering, bargaining, etc.—with each step of the process affecting the outcome of the next, and the optimal decision at each stage depending on the player’s bargaining power. The context in which these negotiations occur—the market—is critical, since players can adjust their behaviors in response to outside offers. Animals similarly are faced with sequential decisions regarding courtship: who to court, how to approach a potential mate, at what level to display, when to give up, etc. Thus economic models of negotiation in a market provide a framework in which we can view not just the outcome of courtship (assortative mating, but also the process, where each sex can use tactics to improve their negotiating outcome, using the assets that they have available. Here we propose to use negotiation as a conceptual framework to explore the factors promoting the tactical adjustments during sequential stages of courtship in lekking species. Our goal is to discuss the utility of negotiation as a heuristic tool, as well as the promise and peril of co-opting game theoretic models from economics to understand animal interactions. We will provide a brief overview of a few areas where we see promise for using negotiation as a framework to understand animal courtship dynamics: choice of a display territory, tactical partner choice for negotiation, approaching a potential partner and courtship haggling [Current Zoology 57 (2: 225–236, 2011].

  6. Marketing Opportunities in the Digital World.

    Science.gov (United States)

    Kiani, G. Reza

    1998-01-01

    Addresses the opportunities offered by the Web to marketers. Considers the Web as a two-way communication model in which four different communication states can take place. Suggests the necessity of new concepts and models for marketers to manage their Web sites, and presents opportunities supporting the marketers' objectives in the new…

  7. Challenges and opportunities for integrating lake ecosystem modelling approaches

    NARCIS (Netherlands)

    Mooij, W.M.; Trolle, D.; Jeppesen, E.; Arhonditsis, G.; Belolipetsky, P.; Chitamwebwa, D.B.R.; Degermendzhy, A.G.; DeAngelis, D.L.; De Senerpont Domis, L.N.; Downing, A.S.; Elliott, J.A.; Fragoso Jr., C.R.; Gaedke, U.; Genova, S.N.; Gulati, R.D.; Håkanson, L.; Hamilton, D.P.; Hipsey, M.R.; ‘t Hoen, P.J.; Hülsmann, S.; Los, F.J.; Makler-Pick, V.; Petzoldt, T.; Prokopkin, I.; Rinke, K.; Schep, S.A.; Tominaga, K.; Van Dam, A.A.; van Nes, E.H.; Wells, S.A.; Janse, J.H.

    2010-01-01

    A large number and wide variety of lake ecosystem models have been developed and published during the past four decades. We identify two challenges for making further progress in this field. One such challenge is to avoid developing more models largely following the concept of others (‘reinventing t

  8. Challenges and opportunities for integrating lake ecosystem modelling approaches

    NARCIS (Netherlands)

    Mooij, W.M.; Trolle, D.; Jeppesen, E.; Arhonditsis, G.; Belolipetsky, P.V.; Chitamwebwa, D.B.R.; Degermendzhy, A.G.; DeAngelis, D.L.; Domis, L.N.D.; Downing, A.S.; Elliott, J.A.; Fragoso, C.R.; Gaedke, U.; Genova, S.N.; Gulati, R.D.; Hakanson, L.; Hamilton, D.P.; Hipsey, M.R.; Hoen, 't J.; Hulsmann, S.; Los, F.H.; Makler-Pick, V.; Petzoldt, T.; Prokopkin, I.G.; Rinke, K.; Schep, S.A.; Tominaga, K.; Dam, van A.A.; Nes, van E.H.; Wells, S.A.; Janse, J.H.

    2010-01-01

    A large number and wide variety of lake ecosystem models have been developed and published during the past four decades. We identify two challenges for making further progress in this field. One such challenge is to avoid developing more models largely following the concept of others ('reinventing t

  9. Modeling root water uptake in soils: opportunities and challenges

    Science.gov (United States)

    Javaux, Mathieu; Couvreur, Valentin; Huber, Katrin; Meunier, Félicien; Vanderborght, Jan; Vereecken, Harry

    2016-04-01

    Root water uptake modeling concepts have evolved over time. On one hand, mesoscopic models have been developed, which explicitly represent the fluxes at the soil root interfaces. On the other hand macroscopic approaches were proposed, which embedded root water uptake into a sink term in the macroscopic mass balance equation. Today, new techniques for imaging root architecture, water fluxes and soil properties open new possibilities to the understanding of water depletion in planted soils. Amongst others, architectural hydraulic root and soil models can be used to bridge the scale gap between single root and plant scales. In this talk, several new promising experimental approaches will be presented together with new models and upscaling procedures, possibly paving the way for the future models of root water uptake. Furthermore, open challenges will also be presented.

  10. 4Mx Soil-Plant Model: Applications, Opportunities and Challenges

    Directory of Open Access Journals (Sweden)

    Nándor Fodor

    2012-12-01

    Full Text Available Crop simulation models describe the main processes of the soil-plant system in a dynamic way usually in a daily time-step. With the help of these models we may monitor the soil- and plant-related processes of the simulated system as they evolve according to the atmospheric and environmental conditions. Crop models could be successfully applied in the following areas: (1 Education: by promoting the system-oriented thinking a comprehensive overview of the interrelations of the soil-plant system as well as of the environmental protection related aspects of the human activities could be presented. (2 Research: The results of observations as well as of experiments could be extrapolated in time and space, thus, for example, the possible effects of the global climate change could be estimated. (3 Practice: Model calculations could be used in intelligent irrigation control and decision supporting systems as well as for providing scientific background for policy makers. The most spectacular feature of the 4Mx crop model is that its graphical user interface enables the user to alter not only the parameters of the model but the function types of its governing equations as well. The applicability of the 4Mx model is presented via several case-studies.

  11. Rodent models in Down syndrome research: impact and future opportunities.

    Science.gov (United States)

    Herault, Yann; Delabar, Jean M; Fisher, Elizabeth M C; Tybulewicz, Victor L J; Yu, Eugene; Brault, Veronique

    2017-10-01

    Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse models with Down-syndrome-related features has been developed to understand this complex human chromosomal disorder. These mouse models have been important for determining genotype-phenotype relationships and identification of dosage-sensitive genes involved in the pathophysiology of the condition, and in exploring the impact of the additional chromosome on the whole genome. Mouse models of Down syndrome have also been used to test therapeutic strategies. Here, we provide an overview of research in the last 15 years dedicated to the development and application of rodent models for Down syndrome. We also speculate on possible and probable future directions of research in this fast-moving field. As our understanding of the syndrome improves and genome engineering technologies evolve, it is necessary to coordinate efforts to make all Down syndrome models available to the community, to test therapeutics in models that replicate the whole trisomy and design new animal models to promote further discovery of potential therapeutic targets. © 2017. Published by The Company of Biologists Ltd.

  12. Key Challenges and Potential Urban Modelling Opportunities in ...

    African Journals Online (AJOL)

    Chris Wray

    monitoring and guiding urban spatial planning and development. ... and social system functions, urban modelling has evolved from simple ... careful long-term planning aligned with the national vision and other strategic perspectives' (GPC,.

  13. A Multi-Objective Model for Planning Equal Employment Opportunities. Research Report No. 23. Revised Edition.

    Science.gov (United States)

    Charnes, A.; And Others

    The document suggests some new modeling approcaches for equal employment opportunity (EEO) planning. Previous manpower planning models of the Office of Civilian Manpower Management have utilized multi-period Markoff processes embedded in goal programing (multiple objective) models. These are here extended to EEO plans directed to changing the mix…

  14. Biofuels and water quality: challenges and opportunities for simulation modeling

    Energy Technology Data Exchange (ETDEWEB)

    Engel, Bernard A. [Purdue University; Chaubey, Indrajeet [Purdue University; Thomas, Mark [Purdue University; Saraswat, Dharmendra [University of Arkansas; Murphy, Patrick [Purdue University; Bhaduri, Budhendra L [ORNL

    2010-01-01

    Quantification of the various impacts of biofuel feedstock production on hydrology and water quality is complex. Mathematical models can be used to efficiently evaluate various what if scenarios related to biofeedstock production and their impacts on hydrology and water quality at various spatial and temporal scales. Currently available models, although having the potential to serve such purposes, have many limitations. In this paper, we review the strengths and weaknesses of such models in light of short- and long term biofeedstock production scenarios. The representation of processes in the currently available models and how these processes need to be modified to fully evaluate various complex biofeedstock production scenarios are discussed. Similarly, issues related to availability of data that are needed to parameterize and evaluate these models are presented. We have presented a vision for the development of decision support tools and ecosystem services that can be used to make watershed management decisions to minimize any potentially adverse environmental impacts while meeting biofeedstock demands. We also discuss a case study of biofeedstock impact simulation in relation to watershed management policy implications for various state and federal agencies in the USA.

  15. Master Data Management Model in Company: Challenges and Opportunity

    Directory of Open Access Journals (Sweden)

    Indrajani

    2015-12-01

    Full Text Available The purpose of this research is to analyze, design, and implement Master Data Management (MDM model for company, which include database processing that will be used in the quality of data customer and produce single view of customer. The research method used is literature study from a variety of journals, books, e-books, and articles on the internet. Also, fact finding techniques are done, such as by analyze, collect, and examine the documents, interviews, and observations. Then, other research methods used to analyze and design MDM model are using cleansing and matching technique. The result obtained from this research is an implementation MDM model for the company, where if implemented, will improve the quality of data significantly. The conclusion which can be obtained from this research is that MDM is one of the factors that can improve the quality of customer data.

  16. Modeling NSCLC Progression: Recent Advances and Opportunities Available

    OpenAIRE

    Suleiman, Ahmed Abbas; Nogova, Lucia; Fuhr, Uwe, 1960-

    2013-01-01

    Non-small cell lung cancer (NSCLC) is one of the leading causes of death around the world with an estimated 5-year relative survival rate of 16% at diagnosis. Development of drugs treating NSCLC is not easy, and the success rate for an anticancer treatment to pass through the whole clinical development process is as low as 5%. Modeling and simulation lend themselves as tools which can potentially streamline drug development. A critical component of the models developed is a description of how...

  17. Addressing diverse learner preferences and intelligences with emerging technologies: Matching models to online opportunities

    Directory of Open Access Journals (Sweden)

    Ke Zhang

    2009-03-01

    Full Text Available This paper critically reviews various learning preferences and human intelligence theories and models with a particular focus on the implications for online learning. It highlights a few key models, Gardner’s multiple intelligences, Fleming and Mills’ VARK model, Honey and Mumford’s Learning Styles, and Kolb’s Experiential Learning Model, and attempts to link them to trends and opportunities in online learning with emerging technologies. By intersecting such models with online technologies, it offers instructors and instructional designers across educational sectors and situations new ways to think about addressing diverse learner needs, backgrounds, and expectations. Learning technologies are important for effective teaching, as are theories and models and theories of learning. We argue that more immense power can be derived from connections between the theories, models and learning technologies. Résumé : Cet article passe en revue de manière critique les divers modèles et théories sur les préférences d’apprentissage et l’intelligence humaine, avec un accent particulier sur les implications qui en découlent pour l’apprentissage en ligne. L’article présente quelques-uns des principaux modèles (les intelligences multiples de Gardner, le modèle VAK de Fleming et Mills, les styles d’apprentissage de Honey et Mumford et le modèle d’apprentissage expérientiel de Kolb et tente de les relier à des tendances et occasions d’apprentissage en ligne qui utilisent les nouvelles technologies. En croisant ces modèles avec les technologies Web, les instructeurs et concepteurs pédagogiques dans les secteurs de l’éducation ou en situation éducationnelle se voient offrir de nouvelles façons de tenir compte des divers besoins, horizons et attentes des apprenants. Les technologies d’apprentissage sont importantes pour un enseignement efficace, tout comme les théories et les modèles d’apprentissage. Nous sommes d

  18. Business models and opportunities for cancer vaccine developers.

    Science.gov (United States)

    Kudrin, Alex

    2012-10-01

    Despite of growing oncology pipeline, cancer vaccines contribute only to a minor share of total oncology-attributed revenues. This is mainly because of a limited number of approved products and limited sales from products approved under compassionate or via early access entry in smaller and less developed markets. However revenue contribution from these products is extremely limited and it remains to be established whether developers are breaking even or achieving profitability with existing sales. Cancer vaccine field is well recognized for high development costs and risks, low historical rates of investment return and high probability of failures arising in ventures, partnerships and alliances. The cost of reimbursement for new oncology agents is not universally acceptable to payers limiting the potential for a global expansion, market access and reducing probability of commercial success. In addition, the innovation in cancer immunotherapy is currently focused in small and mid-size biotech companies and academic institutions struggling for investment. Existing R&D innovation models are deemed unsustainable in current "value-for-money" oriented healthcare environment. New business models should be much more open to collaborative, networked and federated styles, which could help to outreach global, markets and increase cost-efficiencies across an entire value chain. Lessons learned from some developing countries and especially from South Korea illustrate that further growth of cancer vaccine industry will depends not only on new business models but also will heavily rely on regional support and initiatives from different bodies, such as governments, payers and regulatory bodies.

  19. Remote Sensing-Derived Water Extent and Level to Constrain Hydraulic Flood Forecasting Models: Opportunities and Challenges

    Science.gov (United States)

    Grimaldi, Stefania; Li, Yuan; Pauwels, Valentijn R. N.; Walker, Jeffrey P.

    2016-09-01

    Accurate, precise and timely forecasts of flood wave arrival time, depth and velocity at each point of the floodplain are essential to reduce damage and save lives. Current computational capabilities support hydraulic models of increasing complexity over extended catchments. Yet a number of sources of uncertainty (e.g., input and boundary conditions, implementation data) may hinder the delivery of accurate predictions. Field gauging data of water levels and discharge have traditionally been used for hydraulic model calibration, validation and real-time constraint. However, the discrete spatial distribution of field data impedes the testing of the model skill at the two-dimensional scale. The increasing availability of spatially distributed remote sensing (RS) observations of flood extent and water level offers the opportunity for a comprehensive analysis of the predictive capability of hydraulic models. The adequate use of the large amount of information offered by RS observations triggers a series of challenging questions on the resolution, accuracy and frequency of acquisition of RS observations; on RS data processing algorithms; and on calibration, validation and data assimilation protocols. This paper presents a review of the availability of RS observations of flood extent and levels, and their use for calibration, validation and real-time constraint of hydraulic flood forecasting models. A number of conclusions and recommendations for future research are drawn with the aim of harmonising the pace of technological developments and their applications.

  20. The Opportunities and Challenges of Persuasive Technology in Creating Sustainable Innovation and Business Model Innovation

    DEFF Research Database (Denmark)

    Aagaard, Annabeth; Lindgren, Peter

    2015-01-01

    The opportunities of persuasive technology in facilitating sustainable innovation and business model innovation have been witnessed continuously during the last decade. The unique ability of persuasive technology in interacting and mediating across users, customers, decisions makers and other...... stakeholders provides access to core knowledge about behavior and opportunities to influence and even change their behavior in a positive and more sustainable manner. Sustainable innovation and business model innovation is gaining more and more competitive leverage due to customer requirements, the growing......-focused sustainable innovation and business model innovation, which is explored through a theoretical review and case examples in the present study. The findings reveal a number of key opportunities to pursue and a number of critical challenges to adjust to as presented in propositions....

  1. Offer/Acceptance Ratio.

    Science.gov (United States)

    Collins, Mimi

    1997-01-01

    Explores how human resource professionals, with above average offer/acceptance ratios, streamline their recruitment efforts. Profiles company strategies with internships, internal promotion, cooperative education programs, and how to get candidates to accept offers. Also discusses how to use the offer/acceptance ratio as a measure of program…

  2. Digital Dividend Aware Business Models for the Creative Industries: Challenges and Opportunities in EU Markets

    Science.gov (United States)

    Cossiavelou, Vassiliki

    EU counties have a historically unique opportunity to enable their creative industries to promote the knowledge societies, applying new business models to their media content and networks markets, that are digital dividend (DD) aware. This new extra-media gatekeeping factor could shape new alliances and co operations among the member states and the global media markets, as well.

  3. Online communication among adolescents: An integrated model on its attraction, opportunities, and risks.

    NARCIS (Netherlands)

    Valkenburg, P.M.; Peter, J.

    2011-01-01

    Adolescents far outnumber adults in their use of e-communication technologies, such as instant messaging and social network sites. In this article, we present an integrative model that helps us to understand both the appeal of these technologies and their risks and opportunities for the psychosocial

  4. Opportunities for improved risk assessments of exotic species in Canada using bioclimatic modeling.

    Science.gov (United States)

    McKenney, Daniel W; Hopkin, Anthony A; Campbell, Kathy L; Mackey, Brendan G; Foottit, Robert

    2003-01-01

    This paper briefly reviews the process of exotic pest risk assessments and presents some examples of emerging opportunities for spatial bioclimatic modeling of exotic species in Canada. This type of analysis can support risk assessments but does not replace the need for on-going high quality field-based observations to validate and update models. Bioclimatic analysis of several exotic pests is provided to illustrate both opportunities and limits. A link is demonstrated to the National Forest Inventory to characterize timber volumes at risk for one exotic species. 'Challenges' are both scientific and administrative. More accessible and current field survey data are required to improve models. Our experience is that for many exotic species, historical, and even current, data are not always digital or quality controlled for taxonomic identity and accurate geo-referencing. This inhibits their use for integrated spatial modeling applications.

  5. An educational model for preparing Christian nurses and church congregations to offer local whole-person health programmes

    Directory of Open Access Journals (Sweden)

    Helen Anne Wordsworth

    2016-01-01

    Full Text Available The implications of the Tübingen declarations for congregational involvement in health provide the setting for this commentary. Using an example from the United Kingdom, where government health provision has become economically challenging and largely disease focused, the author demonstrates how it is possible to introduce the kind of education for nurses and congregations that will lead to them becoming important sources of whole-person health promotion. In this way, parish nurses and church congregations may make a distinctive contribution that will complement state and private health provision. This model has relevance across all Christian denominations. It is already being followed in 28 different countries, and with appropriate respect to culture, language and health policy, could be globally transferable.

  6. BIG DATA-Related Challenges and Opportunities in Earth System Modeling

    Science.gov (United States)

    Bamzai, A. S.

    2012-12-01

    Knowledge of the Earth's climate has increased immensely in recent decades, both through observational analysis and modeling. BIG DATA-related challenges emerge in our quest for understanding the variability and predictability of the climate and earth system on a range of time scales, as well as in our endeavor to improve predictive capability using state-of-the-science models. To enable further scientific discovery, bottlenecks in current paradigms need to be addressed. An overview of current NSF activities in Earth System Modeling with a focus on associated data-related challenges and opportunities, will be presented.

  7. 土木工程投标报价模型研究(英)%An Offer Model for Civil Engineering Construction

    Institute of Scientific and Technical Information of China (English)

    卢德林; 章祥荪; 糜莺英

    2001-01-01

    本文主要研究单一不可分土木工程的n人投标报价模型.报价高低不是是否中标的唯一决定性因素,施工方案和工程报价为赢得工程施工合同共同发挥组合效应,并且在一定条件下,通过工程竞标,中标价会趋于Nash平衡.%In this paper,we consider an offer model in which one indivisible civil-engineering project of unknown construction cost is tendered to n tenders.The offer is not the sole decisive factor which decides who will get the contract,the tendering plan and the offer can play an important combinatorial role in the competition,and the winner's final offer via the procedure of competitive bidding tends to the symmetric Nash equilibrium in both the probabilistic sense and the economic sense.

  8. Initial Public Offering

    OpenAIRE

    Veselý, Marek

    2009-01-01

    Thesis describes initial public offering on the stock markets. There are mentioned basic phases of this process. In this thesis is named pros & cons of this source of financing. Recommends also other ways how to gain capital for own company business acitivities. Thesis is interested about main conditions for successfull "going public". Initial Public Offering of bonds is described too. Practical part of this thesis is concern IPO in the Czech Republic -- historical data, IPO in the past on Pr...

  9. Brake caliper with offset pads: Innovative brake technology for commercial vehicles offers opportunities to reduce weight and cost; Bremssattel mit tangential versetzten Bremsbelaegen: Innovative Radbremsentechnologie fuer Nutzfahrzeuge bietet neue Moeglichkeiten zur Gewichts- und Kostenreduzierung

    Energy Technology Data Exchange (ETDEWEB)

    Antony, P.; Blatt, P. [WABCO Radbremsen GmbH, Mannheim (Germany)

    2005-07-01

    Continuous optimizations and technical improvements showed no further potential for cost and weight reductions on basis of the conventional technique of a sliding caliper and two supported pads in the carrier. Additionally, global and technical needs are growing. With its 4th generation of air disc brakes and a new caliper concept, WABCO accounts to these developments. Characteristically for the New Generation (NG) is the caliper concept with pad offset in circumferential direction. This presentation describes construction and basics of the system, shows the usage of FEM and elements of Bionic methods and proofs its effectiveness with test bench results. Additional potential for the design of a new interfaces between brake and axle are identified. A significant improved disc cracking behavior offers possibilities for additional cost and weight savings. (orig.)

  10. Recycled Bricks: Exploring Opportunities to Reintegrate Returning American Foreign Fighters Using Existing Models

    Science.gov (United States)

    2016-12-01

    working conditions ( teamwork and working with people they respect), external incentives (money for education and good pay), patriotic adventure...opportunity for adventure and doing something for their country), and equal opportunity (employment opportunities and harassment-free workplace for...opportunities, such as employment opportunities and especially for women and minorities, a harassment-free workplace . While employment is not a primary

  11. Despite the minimalist approach of Grameen Bank training program, similarities may be drawn between its practice and the models offered by Kirkpatrick and others

    Directory of Open Access Journals (Sweden)

    Kazi Abdur Rouf

    2017-01-01

    Full Text Available This paper compares and contrasts training evaluation different models and theories specially applies Kirkpatrick’s (K & K training evaluation model: four levels of measurement and their application in the Gramen Bank (GB training program. The objective of the paper is to know training evaluation models offered by Kirkpatrick and others, and their applications and usefulness to Grameen Bank and other microfinance institutions (MFIs. The paper uses literature review for analyzing of different models of training evaluation. Although K & K how training evaluation model of measuring training depend upon the training program and the demands of top management including stakeholders and donors, this K & K training evaluation model’s four-level training evaluation steps are simple enough that Grameen Bank Bangladesh and other micro-financing institutions (MFIs can adopt it in GB training evaluation process, which can assist GB and other micro-credit micro-management processes in monitoring employees’ performances.

  12. US Clean Energy Sector and the Opportunity for Modeling and Simulation

    Science.gov (United States)

    Inge, Carole Cameron

    2011-01-01

    The following paper sets forth the current understanding of the US clean energy demand and opportunity. As clean energy systems come online and technology is developed, modeling and simulation of these complex energy programs provides an untapped business opportunity. The US Department of Defense provides a great venue for developing new technology in the energy sector because it is demanding lower fuel costs, more energy efficiencies in its buildings and bases, and overall improvements in its carbon footprint. These issues coupled with the security issues faced by foreign dependence on oil will soon bring more clean energy innovations to the forefront (lighter batteries for soldiers, alternative fuel for jets, energy storage systems for ships, etc).

  13. VIP Programs Offer More

    Institute of Scientific and Technical Information of China (English)

    ISABELDING

    2005-01-01

    When choosing a hotel, service standards are a high priority for customers, with the quality of service often reflecting a hotel's standing.While most hotels try to provide the beststandard possible to their guest, many also offer special VIP programs that provide vale-added service and reward customer loyalty.

  14. Offers for our members

    CERN Multimedia

    Staff Association

    2013-01-01

    The Courir shops propose the following offer: 15% discount on all articles (not on sales) in the Courir shops (Val Thoiry, Annemasse and Neydens) and 5% discount on sales upon presentation of your Staff Association membership card and an identity card before payment. Summer is here, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 21 € instead of 26 €. Access to Aqualibi: 5 € instead of 8 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12 h 00. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Day ticket: – Children: 30 CHF instead of 39 CHF – Adults : 36 CHF instead of 49 CHF Bonus! Free for children under 5.

  15. Offers for our members

    CERN Multimedia

    Staff Association

    2017-01-01

    Summer is coming, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 24 € instead of 30 €. Access to Aqualibi: 5 € instead of 6 € on presentation of your SA member ticket. Free for children under 100 cm. Car park free. * * * * * Aquaparc : Day ticket: – Children: 33 CHF instead of 39 CHF – Adults : 33 CHF instead of 49 CHF Bonus! Free for children under 5.

  16. Offers for our members

    CERN Multimedia

    Staff Association

    2017-01-01

    Summer is here, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 24 € instead of 30 €. Access to Aqualibi: 5 € instead of 6 € on presentation of your SA member ticket. Free for children under 100 cm. Car park free. * * * * * Aquaparc : Day ticket: – Children: 33 CHF instead of 39 CHF – Adults : 33 CHF instead of 49 CHF Bonus! Free for children under 5.

  17. Developing an integrated offer for sustainable renovations

    NARCIS (Netherlands)

    Cré, J.; Mlecnik, E.; Kondratenko, I.; Degraeve, P.; Van der Have, J.A.; Vrijders, J.; Van Dessel, J.; Haavik, T.; Aabrekk, S.; Paiho, S.; Stenlund, O.; Svendsen, S.; Vanhoutteghem, L.; Hansen, S.

    2012-01-01

    Within an ERANET-ERACOBUILD project, this study investigates the opportunities and barriers to establish a “one stop shop” with an integrated supply side, to counteract the fragmented offer in sustainable renovation of single-family houses and to increase the level of knowledge, skills and innovatio

  18. Offers for our members

    CERN Multimedia

    Staff Association

    2017-01-01

    Summer is here, enjoy our offers for the water parks! Walibi: Tickets "Zone terrestre": 24 € instead of 30 €. Access to Aqualibi: 5 € instead of 6 € on presentation of your ticket purchased at the Staff Association. Bonus! Free for children under 100 cm, with limited access to the attractions. Free car park. *  *  *  *  *  *  *  * Aquaparc: Day ticket: -  Children: 33 CHF instead of 39 CHF -  Adults : 33 CHF instead of 49 CHF Bonus! Free for children under 5 years old.

  19. Offers for our members

    CERN Multimedia

    Staff Association

    2016-01-01

    Summer is here, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 23 € instead of 29 €. Access to Aqualibi: 5 € instead of 6 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12:00 p.m. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Day ticket: – Children: 33 CHF instead of 39 CHF – Adults : 33 CHF instead of 49 CHF Bonus! Free for children under 5.

  20. Offers for our members

    CERN Multimedia

    Staff Association

    2016-01-01

    Summer is here, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 23 € instead of 29 €. Access to Aqualibi: 5 € instead of 6 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12:00 p.m. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Day ticket: – Children: 33 CHF instead of 39 CHF – Adults : 33 CHF instead of 49 CHF Bonus! Free for children under 5.

  1. Offers for our members

    CERN Multimedia

    Staff Association

    2015-01-01

    Summer is here, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 21,50 € instead of 27 €. Access to Aqualibi: 5 € instead of 6 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12:00 p.m. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Day ticket: – Children: 33 CHF instead of 39 CHF – Adults : 33 CHF instead of 49 CHF Bonus! Free for children under 5.

  2. Offers for our members

    CERN Multimedia

    Staff Association

    2013-01-01

    Summer is here, enjoy our offers for the aquatic parcs! Walibi : Tickets "Zone terrestre": 21 € instead of 26 €. Access to Aqualibi: 5 € instead of 8 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12 h 00. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Day ticket: – Children: 30 CHF instead of 39 CHF – Adults : 36 CHF instead of 49 CHF Bonus! Free for children under 5.

  3. Opportunities with thermoplastics.

    Science.gov (United States)

    Vaahs, Tilo

    2003-04-01

    Whether as substitutes for glass and metal, or completely novel injection moulded applications, engineering polymers offer a range of opportunities for developing cost-effective, safe and smart medical devices.

  4. Density functional theory and beyond-opportunities for quantum methods in materials modeling semiconductor technology.

    Science.gov (United States)

    Shankar, Sadasivan; Simka, Harsono; Haverty, Michael

    2008-02-13

    In the semiconductor industry, the use of new materials has been increasing with the advent of nanotechnology. As critical dimensions decrease, and the number of materials increases, the interactions between heterogeneous materials themselves and processing increase in complexity. Traditionally, applications of ab initio techniques are confined to electronic structure and band gap calculations of bulk materials, which are then used in coarse-grained models such as mesoscopic and continuum models. Density functional theory is the most widely used ab initio technique that was successfully extended to several applications. This paper illustrates applications of density functional theory to semiconductor processes and proposes further opportunities for use of such techniques in process development.

  5. Estimation Of Demand System In An Aids Model:The Opportunity For Exporting Thai Agricultural Products

    Directory of Open Access Journals (Sweden)

    Waripas Jiumpanyarach

    2012-06-01

    Full Text Available This paper reports the results of the estimation of Almost Ideal Demand System(AIDS model is developed to estimate quantity respond based on price. Five major export agricultural products data from the office of Agricultural Economics, Thailand and Biofuel policy from the office of the National Economic and Social Development Broad were used. The AIDS model estimatesdemand of palm, cassava, and sugar are highly response to changed price. Rubber and rice has less response to the changed price. All of major agricultural products are affect expenditure of Thailand export. This result suggest that the opportunity for increasing supply of energy plants, which benefits to Thai farmer communities for expanding market share in energy plants in domestic and global market.

  6. Offers for our members

    CERN Multimedia

    Staff Association

    2013-01-01

    The warm weather arrives, it's time to take advantage of our offers Walibi and Aquapark! Walibi : Tickets "Zone terrestre": 21 € instead of 26 € Access to Aqualibi: 5 € instead of 8 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12 h 00. Free for children under 3, with limited access to the attractions. Car park free. * * * * * Aquaparc : Half-day ticket (5 hours): – Children: 26 CHF instead of 35 CHF – Adults : 32 CHF instead of 43 CHF Day ticket: – Children: 30 CHF instead of 39 CHF – Adults : 36 CHF instead of 49 CHF Free for children under 5.

  7. Offers for our members

    CERN Multimedia

    Association du personnel

    2013-01-01

    La banque LCL propose aux membres de l’Association du personnel les avantages suivants : – Un barème Privilège sur le Prêt immobilier – Des avantages tarifaires sur l’épargne, notamment l’assurance-vie. – Un taux préférentiel de prêt à la consommation. En outre, jusqu’au 30 septembre 2013, elle offre 50€ à tous les nouveaux clients, membres de l'Association du personnel. Summer is here, enjoy our offers for the aquatic parcs! Tickets "Zone terrestre" : 21 € instead of de 26 €. Access to Aqualibi : 5 euros instead of 8 euros on presentation of your SA member ticket. Free for children (3-11 years old) before 12 h 00. Free for children under 3, with limited access to the attractions. Free car park. * * * * * * * Full day ticket: – Children : 30 CHF instead of 39 CHF &...

  8. Sustainable development goals offer new opportunities for tropical delta regions

    OpenAIRE

    2015-01-01

    Marine and lacustrine delta regions constitute only 1% of the Earth's surface but are home to over 500 million people.1 They are key contributors to agricultural production at the national and regional levels and thus enable alleviation of global food insecurity risks. In addition, tropical megadeltas sustain rich ecosystems that provide a variety of services and are noted for high biodiversity and natural resources.2 At the same time, however, their geographical location, coupled with often ...

  9. Evaluating learning opportunities offered to mental health nursing students.

    Science.gov (United States)

    Nganasurian, W E

    1998-10-01

    This article is based upon a thesis submitted in partial fulfilment of the requirements of Anglia Polytechnic University for the degree of Master of Philosophy. The study, completed in 1997, sought to identify factors making a positive contribution to learning within mental health care settings, and, having done this, to develop a means of auditing. Phase One drew on published work; however, it was necessary to determine the contextual validity of factors shown by colleagues to be conductive to learning, since the focus of this earlier work was, in the main, within general adult nursing. Information on the relevance of these factors was obtained from a sample (n = 146) of mental health nursing students, qualified staff, and teachers who responded to a self-completion postal survey, using a questionnaire as the research instrument. Phase Two drew upon the work completed in Phase One. A Likert-type scale audit instrument was developed and administered to a sample (n = 51) of mental health nursing students. In order to test the reliability of this instrument, students'verbal ratings of the quality of their learning experience were compared to numerical ratings provided by the audit instrument resultant from this study. Findings suggest that the instrument provides an effective, efficient means of evaluating learning environments from an individual student's perspective, and as a cumulative profile of student, practice setting and supervisors operating within it. This enables educationalists to identify standards which may be incorporated into future education/service provider contracting arrangements.

  10. Rise of China Offers Many Opportunities for East Asian Countries

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

      As the sixth largest economic country and the third largest trading country in the world, China's rapid development inevitably influences all aspects of the world economy. Since the East Asian countries are adjacent to China, they are also affected by the transition and global change brought by the rise of China. In East Asia,both new industrialized countries and some of ASEAN countries have been seeking export-oriented industrialization earlier than China. Recently China has been catching up with these countries at a surprisingly rapid speed. Similar to the mode of Japanese economic development in the 1980s, China has been regarded as another important motive force for promoting economic transition in East Asia following Japan.……

  11. Rise of China Offers Many Opportunities for East Asian Countries

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ As the sixth largest economic country and the third largest trading country in the world, China's rapid development inevitably influences all aspects of the world economy. Since the East Asian countries are adjacent to China, they are also affected by the transition and global change brought by the rise of China. In East Asia,both new industrialized countries and some of ASEAN countries have been seeking export-oriented industrialization earlier than China. Recently China has been catching up with these countries at a surprisingly rapid speed. Similar to the mode of Japanese economic development in the 1980s, China has been regarded as another important motive force for promoting economic transition in East Asia following Japan.

  12. Opportunities Green Roofs Can Offer Ghanaians and their Cities

    African Journals Online (AJOL)

    Lone Star College System

    2015-08-17

    Aug 17, 2015 ... Review. Green roofs: A possible best management practice for enhancing the ... development in Ghana in this era of climate change and variability. Key words: Green roof, .... mitigation of urban heat island effect and indoor energy consumption. ..... through buildings, air pollution, emission of greenhouse.

  13. A unified view of generative models for networks: models, methods, opportunities, and challenges

    CERN Document Server

    Jacobs, Abigail Z

    2014-01-01

    Research on probabilistic models of networks now spans a wide variety of fields, including physics, sociology, biology, statistics, and machine learning. These efforts have produced a diverse ecology of models and methods. Despite this diversity, many of these models share a common underlying structure: pairwise interactions (edges) are generated with probability conditional on latent vertex attributes. Differences between models generally stem from different philosophical choices about how to learn from data or different empirically-motivated goals. The highly interdisciplinary nature of work on these generative models, however, has inhibited the development of a unified view of their similarities and differences. For instance, novel theoretical models and optimization techniques developed in machine learning are largely unknown within the social and biological sciences, which have instead emphasized model interpretability. Here, we describe a unified view of generative models for networks that draws togethe...

  14. Field, experimental and numerical model developments in outburst flood understanding and opportunities for future work

    Science.gov (United States)

    Carrivick, Jonathan

    2015-04-01

    Local-scale risks to society from a rapidly changing cryosphere include a range of mass flows and floods. Most of these slides, slumps, falls and flow events have been attributed to climatically-induced permafrost degradation, to glaciological mass loss and consequent meltwater production and sudden drainage of glacier lakes, or to volcano-ice interactions. This presentation will firstly overview outburst flood research and knowledge to date and it will do this from a field, experimental and numerical modeling perspective. Fieldwork examples from around the world and including Iceland, New Zealand, Greenland, and the European Alps will be argued to underpin all understanding but to be severely limited in spatiotemporal coverage. Laboratory experiments will be argued to be overly generalised and narrowly-focussed. Numerical models will be argued to be omitting or over-generalising major processes; particularly sediment transport and morphodynamics. This presentation will then look forwards, by placing an emphasis on several recent and major technological advances that should be enabling much improved monitoring and measurement in both the field and the laboratory. The opportunity for new numerical modelling approaches will be discussed from two viewpoints; that of the researcher interested in process mechanisms, and that of the natural hazard manager wishing for real-time information.

  15. Model Meets Data: Challenges and Opportunities to Implement Land Management in Earth System Models

    Science.gov (United States)

    Pongratz, J.; Dolman, A. J.; Don, A.; Erb, K. H.; Fuchs, R.; Herold, M.; Jones, C.; Luyssaert, S.; Kuemmerle, T.; Meyfroidt, P.

    2016-12-01

    Land-based demand for food and fibre is projected to increase in the future. In light of global sustainability challenges only part of this increase will be met by expansion of land use into relatively untouched regions. Additional demand will have to be fulfilled by intensification and other adjustments in management of land that already is under agricultural and forestry use. Such land management today occurs on about half of the ice-free land surface, as compared to only about one quarter that has undergone a change in land cover. As the number of studies revealing substantial biogeophysical and biogeochemical effects of land management is increasing, moving beyond land cover change towards including land management has become a key focus for Earth system modeling. However, a basis for prioritizing land management activities for implementation in models is lacking. We lay this basis for prioritization in a collaborative project across the disciplines of Earth system modeling, land system science, and Earth observation. We first assess the status and plans of implementing land management in Earth system and dynamic global vegetation models. A clear trend towards higher complexity of land use representation is visible. We then assess five criteria for prioritizing the implementation of land management activities: (1) spatial extent, (2) evidence for substantial effects on the Earth system, (3) process understanding, (4) possibility to link the management activity to existing concepts and structures of models, (5) availability of data required as model input. While the first three criteria have been assessed by an earlier study for ten common management activities, we review strategies for implementation in models and the availability of required datasets. We can thus evaluate the management activities for their performance in terms of importance for the Earth system, possibility of technical implementation in models, and data availability. This synthesis reveals

  16. Model meets data: Challenges and opportunities to implement land management in Earth System Models

    Science.gov (United States)

    Pongratz, Julia; Dolman, Han; Don, Axel; Erb, Karl-Heinz; Fuchs, Richard; Herold, Martin; Jones, Chris; Luyssaert, Sebastiaan; Kuemmerle, Tobias; Meyfroidt, Patrick; Naudts, Kim

    2017-04-01

    Land-based demand for food and fibre is projected to increase in the future. In light of global sustainability challenges only part of this increase will be met by expansion of land use into relatively untouched regions. Additional demand will have to be fulfilled by intensification and other adjustments in management of land that already is under agricultural and forestry use. Such land management today occurs on about half of the ice-free land surface, as compared to only about one quarter that has undergone a change in land cover. As the number of studies revealing substantial biogeophysical and biogeochemical effects of land management is increasing, moving beyond land cover change towards including land management has become a key focus for Earth system modeling. However, a basis for prioritizing land management activities for implementation in models is lacking. We lay this basis for prioritization in a collaborative project across the disciplines of Earth system modeling, land system science, and Earth observation. We first assess the status and plans of implementing land management in Earth system and dynamic global vegetation models. A clear trend towards higher complexity of land use representation is visible. We then assess five criteria for prioritizing the implementation of land management activities: (1) spatial extent, (2) evidence for substantial effects on the Earth system, (3) process understanding, (4) possibility to link the management activity to existing concepts and structures of models, (5) availability of data required as model input. While the first three criteria have been assessed by an earlier study for ten common management activities, we review strategies for implementation in models and the availability of required datasets. We can thus evaluate the management activities for their performance in terms of importance for the Earth system, possibility of technical implementation in models, and data availability. This synthesis reveals

  17. Business Models in the Smart Grid: Challenges, Opportunities and Proposals for Prosumer Profitability

    Directory of Open Access Journals (Sweden)

    Jesús Rodríguez-Molina

    2014-09-01

    Full Text Available Considering that non-renewable energy resources are dwindling, the smart grid turns out to be one of the most promising and compelling systems for the future of energy. Not only does it combine efficient energy consumption with avant-garde technologies related to renewable energies, but it is also capable of providing several beneficial utilities, such as power monitoring and data provision. When smart grid end users turn into prosumers, they become arguably the most important value creators within the smart grid and a decisive agent of change in terms of electricity usage. There is a plethora of research and development areas related to the smart grid that can be exploited for new business opportunities, thus spawning another branch of the so-called “green economy” focused on turning smart energy usage into a profitable business. This paper deals with emerging business models for smart grid prosumers, their strengths and weaknesses and puts forward new prosumer-oriented business models, along with their value propositions.

  18. Assets and tactics in a mating market:Economic models of negotiation offer insights into animal courtship dynamics on the lek

    Institute of Scientific and Technical Information of China (English)

    Gail L.PATRICELLI; Alan H.KRAKAUER; Richard MCELREATH

    2011-01-01

    Economists study negotiation as a series of events-partner choice,information gathering,bargaining,etc.-with each step,of the process afffecting the outcome of the next,and the optimal decision at each stage depending on the player's bargaining power.The context in which these negotiations occur-the-market-is critical,since players can adjust their behaviors in response to outside offers.Animals similarly are faced with sequential decisions regarding courtsnip:who to court,how to approaCh a potential mate,at what level to display,when to give up,etc.Thus economic models of negotiation in a market provide a frameword in which we can view not just the outcome of courtship(assortativemating),but also the process,where each sex can use tactics to improve their negotiating outcome,using the assets that they have available.Here we propose to use negotiation as a conceplual framework to explore the factors promoting tactical adjustments during sequential stages of courtship in lekking species.Our goal is to discuss the utility of negotiation as a heuristic tool,as well as the promise and peril of co-opting game theoretic models from economics to understand animal interactions.We will provide a brief overview of a few areas where we see promise for using negotiation as a framework to understand animal courtship dynamics:choice of a display territory,tactical partner choice for negotiation,approaching a potential partner and courtship haggling.

  19. Developing a Model of Advanced Training to Promote Career Advancement for Certified Genetic Counselors: An Investigation of Expanded Skills, Advanced Training Paths, and Professional Opportunities.

    Science.gov (United States)

    Baty, Bonnie J; Trepanier, Angela; Bennett, Robin L; Davis, Claire; Erby, Lori; Hippman, Catriona; Lerner, Barbara; Matthews, Anne; Myers, Melanie F; Robbins, Carol B; Singletary, Claire N

    2016-08-01

    There are currently multiple paths through which genetic counselors can acquire advanced knowledge and skills. However, outside of continuing education opportunities, there are few formal training programs designed specifically for the advanced training of genetic counselors. In the genetic counseling profession, there is currently considerable debate about the paths that should be available to attain advanced skills, as well as the skills that might be needed for practice in the future. The Association of Genetic Counseling Program Directors (AGCPD) convened a national committee, the Committee on Advanced Training for Certified Genetic Counselors (CATCGC), to investigate varied paths to post-master's training and career development. The committee began its work by developing three related grids that view career advancement from the viewpoints of the skills needed to advance (skills), ways to obtain these skills (paths), and existing genetic counselor positions that offer career change or advancement (positions). Here we describe previous work related to genetic counselor career advancement, the charge of the CATCGC, our preliminary work in developing a model through which to view genetic counselor advanced training and career advancement opportunities, and our next steps in further developing and disseminating the model.

  20. Missed opportunities in the DSM-5 Section III personality disorder model: commentary on "personality disorders are the vanguard of the post-DSM-5.0 era".

    Science.gov (United States)

    Miller, Joshua D; Lynam, Donald R

    2013-10-01

    Comments on an article by Krueger (see record 2013-45025-008). The current authors appreciate the opportunity to comment on Krueger's article. They remark that as a member of the DSM-5 (American Psychiatric Association, 2013) Personality and Personality Disorders Work Group (PPDWG), he is in a unique position to describe the process surrounding the deliberations of the PPDWG and why their model was placed in Section III. Whereas Krueger offers that too much openness and contentiousness in the personality and personality disorder (PD) field were responsible for the difficulties faced by the DSM-5 PPDWG proposal, the current authors suggest another condition that may have been at play: myopia. The current authors discuss several shortsighted decisions made by the PPDWG that may have contributed to the disappointing outcome. Specifically, they describe ways in which the PPDWG ignored large bodies of extant research that could have guided and supported the proposal, inoculating it against many of the most damning critiques.

  1. Methodological challenges and analytic opportunities for modeling and interpreting Big Healthcare Data.

    Science.gov (United States)

    Dinov, Ivo D

    2016-01-01

    Managing, processing and understanding big healthcare data is challenging, costly and demanding. Without a robust fundamental theory for representation, analysis and inference, a roadmap for uniform handling and analyzing of such complex data remains elusive. In this article, we outline various big data challenges, opportunities, modeling methods and software techniques for blending complex healthcare data, advanced analytic tools, and distributed scientific computing. Using imaging, genetic and healthcare data we provide examples of processing heterogeneous datasets using distributed cloud services, automated and semi-automated classification techniques, and open-science protocols. Despite substantial advances, new innovative technologies need to be developed that enhance, scale and optimize the management and processing of large, complex and heterogeneous data. Stakeholder investments in data acquisition, research and development, computational infrastructure and education will be critical to realize the huge potential of big data, to reap the expected information benefits and to build lasting knowledge assets. Multi-faceted proprietary, open-source, and community developments will be essential to enable broad, reliable, sustainable and efficient data-driven discovery and analytics. Big data will affect every sector of the economy and their hallmark will be 'team science'.

  2. Can an Opportunity to Learn at Work Reduce Stress?: A Revisitation of the Job Demand-Control Model

    Science.gov (United States)

    Panari, Chiara; Guglielmi, Dina; Simbula, Silvia; Depolo, Marco

    2010-01-01

    Purpose: This paper aims to extend the stress-buffering hypothesis of the demand-control model. In addition to the control variable, it seeks to analyse the role of an opportunity for learning and development (L&D) in the workplace as a moderator variable between increased demands and need for recovery. Design/methodology/approach: A…

  3. Offers

    CERN Multimedia

    Staff Association

    2014-01-01

    To our members 5% discount on Fnac vouchers Vouchers of 50.-, 100.- et 200. - CHF Valid in the 4 shops in Switzerland without restriction on purchases. On sale in the office of Secretariat of the staff Association.

  4. Offers

    CERN Multimedia

    Staff Association

    2014-01-01

    12 % discount on football camps and courses for children from 3 to 13 years old, with bilingual coaches.   Now also courses during the autumn holidays! In order to get the discount you need to register online, then send a mail to info@intersoccer.ch with a scan of your membership card to recieve a refund of the discount.

  5. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    Découvrez les plus belles tables de Suisse romande et de France voisine en bénéficiant des réductions suivantes sur chaque repas, pendant une année : 50 % pour 2 personnes / 40 % pour 3 personnes / 30 % pour 4 personnes / 20 % pour 5 à 6 personnes. Comment ça marche ? Faites votre choix parmi les 110 restaurants de votre région et réservez votre table pour 2, 3, 4, 5 ou 6 personnes. Présentez votre Passeport Gourmand dès votre arrivée. Savourez votre repas et profitez d’une réduction exceptionnelle sur votre addition (hors boissons, menu du jour et business lunch). Quels sont vos avantages ? Profitez du prix préférentiel pour les membres de l’association du CERN : – Passeport Gourmand Genève : CHF 75.- (au lieu de CHF 95.-) – Passeport Gourmand Ain/Savoie/Haute-Savoie : CHF 59.- (au lieu de...

  6. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    Découvrez les plus belles tables de Suisse romande et de France voisine en bénéficiant des réductions suivantes sur chaque repas, pendant une année : 50 % pour 2 personnes, 40 % pour 3 personnes, 30 % pour 4 personnes, 20 % pour 5 à 6 personnes. Comment ça marche ? Faites votre choix parmi les 110 restaurants de votre région et réservez votre table pour 2, 3, 4, 5 ou 6 personnes. Présentez votre Passeport Gourmand dès votre arrivée. Savourez votre repas et profitez d’une réduction exceptionnelle sur votre addition (hors boissons, menu du jour et business lunch). Quels sont vos avantages ? Profitez du prix préférentiel pour les membres de l’association du CERN : – Passeport Gourmand Genève : CHF 75.- (au lieu de CHF 95.-) – Passeport Gourmand Ain/Savoie/Haute-Savoie : CHF 59.- (au lieu de CH...

  7. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    Concert Scoop music tour sur le parc Walibi ! Vendredi 12 Juillet Vous trouverez la présentation de l’événement et les vidéos des artistes attendus avec leurs titres faisant vibrer les radios en ce moment sur le site internet http://www.walibi.com/rhone-alpes/fr-fr/evenements/scoop-music-tour. Le concert est gratuit et débute à la fermeture du parc avec une première partie surprise. Profitez donc d’une belle journée sur le parc et finissez en beauté avec le concert de l’été !

  8. Offers

    CERN Multimedia

    Association du personnel

    2010-01-01

    LA BÂTIE-FESTIVAL DE GENEVE Offre pour les membres de l'association du personnel du CERN   P r é s e n t a t i o n L a B â t i e-F e s t i v a l d e G e n è v e : Festival pluridisciplinaire et contemporain, souvent qualifié de «tête chercheuse», La Bâtie-Festival de Genève permet durant deux semaines de découvrir plus de 40 spectacles d’artistes emblématiques d’ici ou d’ailleurs, aussi bien pour les grands que les petits (mini-Bâtie). De la danse, du théâtre, de la musique, du 3 au 18 septembre 2010 nous recevrons près de 300 artistes dans une vingtaine de salles à Genève et en France voisine (Annemasse et Divonne). La Bâtie c’est aussi deux lieux de rencontre et d’échange, Le Tampopo, notre restaurant-l...

  9. Offers

    CERN Multimedia

    Staff association

    2014-01-01

        Envie de soirée au théâtre, n’hésitez pas à bénéficier de nos offres pour nos membres ! Théâtre de Carouge : Réduction de 5 CHF pour tous les spectacles (30 CHF au lieu de 35 CHF) Le théâtre de Carouge vous présente sa nouvelle pièce : La double insconstance Du vedredi 21 mars au dimanche 6 avril 2014 De Marivaux Mise en scène de Philippe Mentha Audio-description le mardi 1er avril et le samedi 5 avril 2014 Il règne un doux mélange de révoltes et de séductions, de ruses et de fatalité dans cette Double Inconstance de Marivaux que met en scène Philippe Mentha, membre fondateur du Théâtre de Carouge et directeur depuis plus de trente ans du Théâtre Kléber-Méleau. L’allure d...

  10. Offers

    CERN Multimedia

    Staff Association

    2014-01-01

      Bénéficiez du tarif spécial de 35 CHF/personne + 1 accompagnant au Théâtre de Carouge  en étant membre de l’Association du personnel.  Envoyez votre réservation par mail à smills@tcag.ch via votre adresse mail professionnelle. Indiquez la date de votre réservation, votre nom, prénom et numéro de téléphone. Une confirmation de réservation vous sera retournée par mail. La présentation de votre carte de membre sera demandée lors du retrait des billets.   De Molière – Mise en scène de Jean Liermier Argan, veuf, remarié avec Béline qui n’attend que la mort de son mari pour hériter, multiplie saignées, purges et autres ingestions de remèdes. Angélique, sa fille, vuet &a...

  11. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    Tickets "Zone terrestre": 21.50 € instead of 27 €. Access to Aqualibi: 5 € instead of 8 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12 h 00. Free for children under 3, with limited access to the attractions. Car park free.

  12. Offer

    CERN Multimedia

    Staff Association

    2015-01-01

    Le parc ouvre ses portes le samedi 4 avril 2015!   La Chasse aux Oeufs du 4 au 26 avril En plus de ses 25 attractions et spectacles, le parc proposera aux enfants de 3 à 12 ans de relever le challenge d’une course aux oeufs dans un jardin de Pâques reconstitué ! Autant de petits oeufs à trouver dans un temps limite ; tout cela au milieu de lapins, poules, fleurs et autres oeufs géants pour repartir avec des gourmandises en chocolat de la marque Revillon Chocolatier.   Profitez de notre offre spéciale pour nos membres : Tarif unique Adulte/Enfant Entrée Zone terrestre 21,50 euros au lieu de 27 euros Accès à l’Aqualibi : 5 euros au lieu de 8 euros sur présentation du billet d’entrée au tarif membre AP. Entrée gratuite pour les enfants de moins de 3 ans, avec accès limité aux attractions. Les billet...

  13. Offers

    CERN Multimedia

    Staff Association

    2015-01-01

    Tickets "Zone terrestre": 21 € instead of 27 €. Access to Aqualibi: 5 € instead of 8 € on presentation of your SA member ticket. Free for children (3-11 years old) before 12 h 00. Free for children under 3, with limited access to the attractions. Car park free.

  14. OFFERS

    CERN Multimedia

    Staff Association

    2014-01-01

    Nouveau partenaire - Joy’s Club   Venez profiter des remises au Joy’s Club / Minigolf à Divonne-les-bains en tant que membre de l’Association ! Sur présentation de votre carte membre, vous bénéficierez d’une remise immédiate telle que : - Pour une partie adulte : 6 euros au lieu de 7 euros - Pour une partie enfant : 4 euros au lieu de 5 euros - Pour le mini Park : 6 euros au lieu de 7 euros Pour plus de renseignements, n’hésitez pas à demander au Secrétariat de l’Association ou à consulter notre site web: http://staff-association.web.cern.ch/fr/socioculturel/offres  

  15. Offers

    CERN Multimedia

    Staff Association

    2012-01-01

    Si cette offre vous intéresse, merci d’envoyer un mail à mh.boulanger@comedie.ch avec le détail de votre réservation via votre adresse mail professionnelle. Le retrait des places se fait à la billetterie sur présentation de votre carte de membre de l’Association du personnel. Pour toute commande d’abonnement ou de carte de réduction par courrier ou internet, cocher le tarif collectif en indiquant le nom de l’entreprise et en joignant un justificatif nominatif. Pour tout renseignement, n’hésitez pas à contacter Marie-Hélène Boulanger : –  Tel. : 022 809 60 86 –  email : mh.boulanger@comedie.ch

  16. Revisiting the destination ranking procedure in development of an Intervening Opportunities Model for public transit trip distribution

    Science.gov (United States)

    Nazem, Mohsen; Trépanier, Martin; Morency, Catherine

    2015-01-01

    An Enhanced Intervening Opportunities Model (EIOM) is developed for Public Transit (PT). This is a distribution supply dependent model, with single constraints on trip production for work trips during morning peak hours (6:00 a.m.-9:00 a.m.) within the Island of Montreal, Canada. Different data sets, including the 2008 Origin-Destination (OD) survey of the Greater Montreal Area, the 2006 Census of Canada, GTFS network data, along with the geographical data of the study area, are used. EIOM is a nonlinear model composed of socio-demographics, PT supply data and work location attributes. An enhanced destination ranking procedure is used to calculate the number of spatially cumulative opportunities, the basic variable of EIOM. For comparison, a Basic Intervening Opportunities Model (BIOM) is developed by using the basic destination ranking procedure. The main difference between EIOM and BIOM is in the destination ranking procedure: EIOM considers the maximization of a utility function composed of PT Level Of Service and number of opportunities at the destination, along with the OD trip duration, whereas BIOM is based on a destination ranking derived only from OD trip durations. Analysis confirmed that EIOM is more accurate than BIOM. This study presents a new tool for PT analysts, planners and policy makers to study the potential changes in PT trip patterns due to changes in socio-demographic characteristics, PT supply, and other factors. Also it opens new opportunities for the development of more accurate PT demand models with new emergent data such as smart card validations.

  17. Opportunity Design

    DEFF Research Database (Denmark)

    2012-01-01

    or development oriented, the act of ‘recognition’ is still a central part of the definition. Recently the term “Opportunity Design” has been introduced, suggesting that opportunities can be proactively and intentionally designed. However, the relatedness between the opportunity recognition process...... and opportunity design is not clear. Furthermore, there is still a lack of approaches, methods and tools, which can support entrepreneurs in designing the entrepreneurial opportunities. In this paper, we take steps towards defining opportunity design in respect to the opportunity recognition process, and identify...... some of the specific approaches applicable to the design of opportunities. By looking at industrial designers working with entrepreneurial opportunities, it becomes evident that there is a set of approaches, which can turn the opportunity recognition process into an intentional and proactive process....

  18. Opportunity Design

    DEFF Research Database (Denmark)

    2012-01-01

    some of the specific approaches applicable to the design of opportunities. By looking at industrial designers working with entrepreneurial opportunities, it becomes evident that there is a set of approaches, which can turn the opportunity recognition process into an intentional and proactive process....... or development oriented, the act of ‘recognition’ is still a central part of the definition. Recently the term “Opportunity Design” has been introduced, suggesting that opportunities can be proactively and intentionally designed. However, the relatedness between the opportunity recognition process...... and opportunity design is not clear. Furthermore, there is still a lack of approaches, methods and tools, which can support entrepreneurs in designing the entrepreneurial opportunities. In this paper, we take steps towards defining opportunity design in respect to the opportunity recognition process, and identify...

  19. Opportunities for Using Building Information Modeling to Improve Worker Safety Performance

    Directory of Open Access Journals (Sweden)

    Kasim Alomari

    2017-02-01

    Full Text Available Building information modelling (BIM enables the creation of a digital representation of a designed facility combined with additional information about the project attributes, performance criteria, and construction process. Users of BIM tools point to the ability to visualize the final design along with the construction process as a beneficial feature of using BIM. Knowing the construction process in relationship to a facility’s design benefits both safety professionals when planning worker safety measures for a project and designers when creating a project’s design. Success in using BIM to enhance safety partly depends on the familiarity of project personnel with BIM tools and the extent to which the tools can be used to identify and eliminate safety hazards. In a separate, ongoing study, the authors investigated the connection between BIM and safety to document the opportunities, barriers, and impacts. Utilizing an on-line survey of project engineers who work for construction firms together with a comprehensive literature review, the study found those who use BIM feel that it aids in communication of project information and project delivery, both of which have been found to have positive impacts on construction site safety. Further, utilizing the survey results, the authors apply the binary logistic regression econometric framework to better understand the factors that lead to safety professionals believing that BIM increases safety in the work place. In addition, according to the survey results, a large percentage of the engineers who use BIM feel that ultimately it helps to eliminate safety hazards and improve worker safety. The study findings suggest that improvements in safety performance across the construction industry may be due in part to increased use of BIM in the construction industry.

  20. Three-dimensional in vitro cancer spheroid models for Photodynamic Therapy: Strengths and Opportunities

    Directory of Open Access Journals (Sweden)

    Conor L Evans

    2015-03-01

    Full Text Available Three dimensional, in vitro spheroid cultures offer considerable utility for the development and testing of anticancer photodynamic therapy regimens. More complex than monolayer cultures, three-dimensional spheroid systems replicate many of the important cell-cell and cell-matrix interactions that modulate treatment response in vivo. Simple enough to be grown by the thousands and small enough to be optically interrogated, spheroid cultures lend themselves to high-content and high-throughput imaging approaches. These advantages have enabled studies investigating photosensitizer uptake, spatiotemporal patterns of therapeutic response, alterations in oxygen diffusion and consumption during therapy, and the exploration of mechanisms that underlie therapeutic synergy. The use of quantitative imaging methods, in particular, has accelerated the pace of three-dimensional in vitro photodynamic therapy studies, enabling the rapid compilation of multiple treatment response parameters in a single experiment. Improvements in model cultures, the creation of new molecular probes of cell state and function, and innovations in imaging toolkits will be important for the advancement of spheroid culture systems for future photodynamic therapy studies.

  1. Use of several Cloud Computing approaches for climate modelling: performance, costs and opportunities

    Science.gov (United States)

    Perez Montes, Diego A.; Añel Cabanelas, Juan A.; Wallom, David C. H.; Arribas, Alberto; Uhe, Peter; Caderno, Pablo V.; Pena, Tomas F.

    2017-04-01

    Cloud Computing is a technological option that offers great possibilities for modelling in geosciences. We have studied how two different climate models, HadAM3P-HadRM3P and CESM-WACCM, can be adapted in two different ways to run on Cloud Computing Environments from three different vendors: Amazon, Google and Microsoft. Also, we have evaluated qualitatively how the use of Cloud Computing can affect the allocation of resources by funding bodies and issues related to computing security, including scientific reproducibility. Our first experiments were developed using the well known ClimatePrediction.net (CPDN), that uses BOINC, over the infrastructure from two cloud providers, namely Microsoft Azure and Amazon Web Services (hereafter AWS). For this comparison we ran a set of thirteen month climate simulations for CPDN in Azure and AWS using a range of different virtual machines (VMs) for HadRM3P (50 km resolution over South America CORDEX region) nested in the global atmosphere-only model HadAM3P. These simulations were run on a single processor and took between 3 and 5 days to compute depending on the VM type. The last part of our simulation experiments was running WACCM over different VMS on the Google Compute Engine (GCE) and make a comparison with the supercomputer (SC) Finisterrae1 from the Centro de Supercomputacion de Galicia. It was shown that GCE gives better performance than the SC for smaller number of cores/MPI tasks but the model throughput shows clearly how the SC performance is better after approximately 100 cores (related with network speed and latency differences). From a cost point of view, Cloud Computing moves researchers from a traditional approach where experiments were limited by the available hardware resources to monetary resources (how many resources can be afforded). As there is an increasing movement and recommendation for budgeting HPC projects on this technology (budgets can be calculated in a more realistic way) we could see a shift on

  2. Cigarette promotional offers: who takes advantage?

    Science.gov (United States)

    White, Victoria M; White, Martha M; Freeman, Karen; Gilpin, Elizabeth A; Pierce, John P

    2006-03-01

    Promotional offers on cigarettes (e.g., dollar-off, multipack discounts) composed the largest share of tobacco industry marketing expenditures, totaling $8.9 billion, or 72% of the total budget in 2002. Internal industry documents indicate that young adults, potential quitters, and other price-sensitive groups are the targets of these marketing tactics. How effective they are in actually reaching these groups in the general population of smokers has not yet been investigated. Data were from 4618 current smokers responding to the large, random-digit-dialed population-based 2002 California Tobacco Survey. The characteristics were identified of smokers who reported that they used these offers "every time I see one." Thirty-five percent of smokers used promotional offers every time they saw one. Multivariate analyses identified young adults, women, African Americans, those with higher daily cigarette consumption, and those worried about cigarette costs as more likely to use promotional offers at every opportunity. Smokers most committed to quitting were no more likely to use promotional offers than those with no intention to quit. Cigarette brand was highly correlated with age and race/ethnicity, and therefore was not included in the multivariate analysis. Those who smoked menthol cigarettes and Camels, more often young adults and African Americans, were much more likely than those of other brands to use promotional offers. With the exception of smokers intending to quit, cigarette promotional offers are effectively reaching most industry-targeted groups. Importantly, young adults, who have the greatest long-term customer potential, are responding.

  3. Modeling Distribution and Abundance of Antarctic Baleen Whales Using Ships of Opportunity

    Directory of Open Access Journals (Sweden)

    Rob Williams

    2006-06-01

    Full Text Available Information on animal abundance and distribution is at the cornerstone of many wildlife and conservation strategies. However, these data can be difficult and costly to obtain for cetacean species. The expense of sufficient ship time to conduct design-unbiased line transect surveys may be simply out of reach for researchers in many countries, which nonetheless grapple with problems of conservation of endangered species, by-catch of small cetaceans in commercial fisheries, and progression toward ecosystem-based fisheries management. Recently developed spatial modeling techniques show promise for estimating wildlife abundance using non-randomized surveys, but have yet to receive much field-testing in areas where designed surveys have also been conducted. Effort and sightings data were collected along 9 650 km of transects aboard ships of opportunity in the Southern Ocean during the austral summers of 2000-2001 and 2001-2002. Generalized additive models with generalized cross-validation were used to express heterogeneity of cetacean sightings as functions of spatial covariates. Models were used to map predicted densities and to estimate abundance of humpback, minke, and fin whales in the Drake Passage and along the Antarctic Peninsula. All species' distribution maps showed strong density gradients, which were robust to jackknife resampling when each of 14 trips was removed sequentially with replacement. Looped animations of model predictions of whale density illustrate uncertainty in distribution estimates in a way that is informative to non-scientists. The best abundance estimate for humpback whales was 1 829 (95% CI: 978-3 422. Abundance of fin whales was 4 487 (95% CI: 1 326-15 179 and minke whales was 1,544 (95% CI: 1,221-1,953. These estimates agreed roughly with those reported from a designed survey conducted in the region during the previous austral summer. These estimates assumed that all animals on the trackline were detected, but

  4. A Model Lesson: Finland Shows Us What Equal Opportunity Looks Like

    Science.gov (United States)

    Sahlberg, Pasi

    2012-01-01

    International indicators show that Finland has one of the most educated citizenries in the world, provides educational opportunities in an egalitarian manner, and makes efficient use of resources. But at the beginning of the 1990s, education in Finland was nothing special in international terms. The performance of Finnish students on international…

  5. Classroom ICT Integration in Tanzania: Opportunities and Challenges from the Perspectives of TPACK and SAMR Models

    Science.gov (United States)

    Kihoza, Patrick; Zlotnikova, Irina; Bada, Joseph; Kalegele, Khamisi

    2016-01-01

    With the education systems demand of contemporary technologies, teacher trainees should be imparted with competencies and skills to integrate information and communication technology (ICT) into their future teaching and learning practices. This study assessed classroom ICTs integration opportunities and the challenges in relation to Technological…

  6. The guiding nature of the kawa (river) model in Ireland: creating both opportunities and challenges for occupational therapists.

    Science.gov (United States)

    Carmody, Sarah; Nolan, Riona; Ni Chonchuir, Niamhh; Curry, Maria; Halligan, Catherine; Robinson, Katie

    2007-01-01

    The kawa (kawa is Japanese for 'river') model of occupational therapy has recently emerged in response to the needs for culturally sensitive conceptual models of practice that adequately address clients' diverse cultures and belief systems (Iwama, 2006a). The present article reports two case studies in which the kawa model was used to guide occupational therapy intervention with two individuals with multiple sclerosis in Ireland, with the aim of exploring the effectiveness of the recently emerged kawa model. A qualitative grounded theory approach using case-study methodology was undertaken. Semi-structured interviews based on the kawa model were completed with two participants with multiple sclerosis before and after occupational therapy intervention. The authors also documented their experience of using the model in reflective diaries. Analysis revealed a core category of the guiding nature of the kawa model creating both opportunities and challenges. Opportunities afforded by the model included enablement of the occupational therapy process and facilitation of occupation-based practice. Challenges created by the use of the kawa model included participant uncertainty and the influence of therapist preconceptions. Limitations and recommendations for future research are discussed in terms of generalizability. Further research with greater numbers and more diversity of study participants is required to validate the tentative theory proposed.

  7. What We Offer | FNLCR Staging

    Science.gov (United States)

    Opportunities We recognize that employee benefit programs are an important part of the total compensation package, and are committed to providing you with comprehensive benefit options. The Frederick National Lab's prime contractor, Leidos Biomedi

  8. Opportunities for Cross-Border Entrepreneurship Development in a Cluster Model Exemplified by the Polish–Czech Border Region

    OpenAIRE

    Joanna Kurowska-Pysz

    2016-01-01

    The subject of the paper is the analysis and evaluation of cross-border entrepreneurship development opportunities on the basis of cross-border cooperation, which has gradually evolved from consisting of bilateral partnerships to a networking model or even a cluster. The study conducted at the Polish–Czech border area indicates that, in terms of the development of cross-border cooperation, the economic sphere is lagging far behind social activities such as culture, education and tourism. At t...

  9. Corrosion chemistry closing comments: opportunities in corrosion science facilitated by operando experimental characterization combined with multi-scale computational modelling.

    Science.gov (United States)

    Scully, John R

    2015-01-01

    Recent advances in characterization tools, computational capabilities, and theories have created opportunities for advancement in understanding of solid-fluid interfaces at the nanoscale in corroding metallic systems. The Faraday Discussion on Corrosion Chemistry in 2015 highlighted some of the current needs, gaps and opportunities in corrosion science. Themes were organized into several hierarchical categories that provide an organizational framework for corrosion. Opportunities to develop fundamental physical and chemical data which will enable further progress in thermodynamic and kinetic modelling of corrosion were discussed. These will enable new and better understanding of unit processes that govern corrosion at the nanoscale. Additional topics discussed included scales, films and oxides, fluid-surface and molecular-surface interactions, selected topics in corrosion science and engineering as well as corrosion control. Corrosion science and engineering topics included complex alloy dissolution, local corrosion, and modelling of specific corrosion processes that are made up of collections of temporally and spatially varying unit processes such as oxidation, ion transport, and competitive adsorption. Corrosion control and mitigation topics covered some new insights on coatings and inhibitors. Further advances in operando or in situ experimental characterization strategies at the nanoscale combined with computational modelling will enhance progress in the field, especially if coupling across length and time scales can be achieved incorporating the various phenomena encountered in corrosion. Readers are encouraged to not only to use this ad hoc organizational scheme to guide their immersion into the current opportunities in corrosion chemistry, but also to find value in the information presented in their own ways.

  10. Model-based drug development: strengths, weaknesses, opportunities, and threats for broad application of pharmacometrics in drug development.

    Science.gov (United States)

    Wetherington, Jeffrey D; Pfister, Marc; Banfield, Christopher; Stone, Julie A; Krishna, Rajesh; Allerheiligen, Sandy; Grasela, Dennis M

    2010-09-01

    Systematic implementation of model-based drug development (MBDD) to drug discovery and development has the potential to significantly increase the rate of medical breakthroughs and make available new and better treatments to patients. An analysis of the strengths, weaknesses, opportunities, and threats (ie, SWOT) was conducted through focus group discussions that included 24 members representing 8 pharmaceutical companies to systematically assess the challenges to implementing MBDD into the drug development decision-making process. The application of the SWOT analysis to the successful implementation of MBDD yielded 19 strengths, 27 weaknesses, 34 opportunities, and 22 threats, which support the following conclusions. The shift from empirical drug development to MBDD requires a question-based mentality; early, proactive planning; dynamic access to multisource data; quantitative knowledge integration; multidisciplinary collaboration; effective communication and leadership skills; and innovative, impactful application of pharmacometrics focused on enhancing quantitative decision making. The ultimate goal of MBDD is to streamline discovery and development of innovative medicines to benefit patients.

  11. New Opportunities for Targeted Immunotherapy

    Science.gov (United States)

    A team of NCI researchers has reported that several types of gastrointestinal cancer have tumor-specific mutations that can be recognized by the immune system, thereby offering a new therapeutic opportunity for patients with these tumors.

  12. Network marketing as an opportunity

    OpenAIRE

    Hakun, Peter

    2010-01-01

    The objective of this thesis is to clarify network marketing and how it works and to describe its advantages, disadvantages and opportunity which it offers to producer, distributor and consumer. The first chapter gives a definition of network marketing, explains how it works and refers to its history. In the second chapter the network marketing is compared to common distribution chain from producer's as well as consumer's point of view. Opportunities which network marketing offers to a distri...

  13. Network marketing as an opportunity

    OpenAIRE

    Hakun, Peter

    2010-01-01

    The objective of this thesis is to clarify network marketing and how it works and to describe its advantages, disadvantages and opportunity which it offers to producer, distributor and consumer. The first chapter gives a definition of network marketing, explains how it works and refers to its history. In the second chapter the network marketing is compared to common distribution chain from producer's as well as consumer's point of view. Opportunities which network marketing offers to a distri...

  14. NASA's Earth Observations Commercialization Applications Program: A model for government promotion of commercial space opportunities

    Science.gov (United States)

    Macauley, Molly K.

    1995-01-01

    The role of government in promoting space commerce is a topic of discussion in every spacefaring nation. This article describes a new approach to government intervention which, based on its five-year track record, appears to have met with success. The approach, developed in NASA's Earth Observations Commercialization Application Program (EOCAP), offer several lessons for effective government sponsorship of commercial space development in general and of commercial remote sensing in particular.

  15. Vacancy Duration, Wage Offers, and Job Requirements

    DEFF Research Database (Denmark)

    Eriksson, Tor Viking; Chen, Long-Hwa

    is concerned with how vacancy durations vary with firms' minimum wage offers and minimum job requirements (regarding education, skills, age, gender and earlier work experience). The empirical analysis is based on ten employer surveys carried out by the DGBAS on Taiwan during the period 1996-2006. We estimate......Besides wage offers, credentials like education, work experience and skill requirements are key screening tools for firms in their recruitment of new employees. This paper adds some new evidence to a relatively tiny literature on firms' recruitment behaviour. In particular, our analysis...... logistic discrete hazard models with a rich set of job and firm characteristics as explanatory variables. The results show that vacancies associated with higher wage offers take, ceteris paribus, longer to be filled. The impact of firms' wage offers and credential requirements does not vary over...

  16. Breaking the entry barriers of startup companies to offer AAL services through integrated eHealth solutions based on a hybrid business model

    DEFF Research Database (Denmark)

    Kyriazakos, Sofoklis

    Healthcare sector is one of the main pillars of the economy at a global level that involves patients, physicians, National Health Systems, insurance companies, pharmaceuticals, vendors, researchers and providers. Healthcare sector represents a good portion of the GDP of any Government and attract...... Organizations (CRO). The full paper will elaborate on the hybrid business model and present how a multi-million € research project has applied this model in order to encounter the challenges and create a solid startup....

  17. Opportunity Design

    DEFF Research Database (Denmark)

    Løwe Nielsen, Suna; Lassen, Astrid Heidemann; Nielsen, Louise Møller

    2013-01-01

    in a market setting (the back-end of entrepreneurial processes), it pays less attention to how entrepreneurs purposely design opportunities (the front-end of entrepreneurial processes). Drawing on methods and processes from the creative design literature, the paper introduces a framework of “opportunity...

  18. Opportunity Design

    DEFF Research Database (Denmark)

    Løwe Nielsen, Suna; Lassen, Astrid Heidemann; Nielsen, Louise Møller

    2013-01-01

    design”. The framework explains how opportunities intentionally and pro-actively can be designed from methods and processes of moving-in and moving-out. An illustrative case of opportunity design within the area of sustainable energy and electric cars is presented to link the theoretical discussion...

  19. Development of a Coherent Bistatic Vegetation Model for Signal of Opportunity Applications at VHF UHF-Bands

    Science.gov (United States)

    Kurum, Mehmet; Deshpande, Manohar; Joseph, Alicia T.; O'Neill, Peggy E.; Lang, Roger H.; Eroglu, Orhan

    2017-01-01

    A coherent bistatic vegetation scattering model, based on a Monte Carlo simulation, is being developed to simulate polarimetric bi-static reflectometry at VHF/UHF-bands (240-270 MHz). The model is aimed to assess the value of geostationary satellite signals of opportunity to enable estimation of the Earth's biomass and root-zone soil moisture. An expression for bistatic scattering from a vegetation canopy is derived for the practical case of a ground-based/low altitude platforms with passive receivers overlooking vegetation. Using analytical wave theory in conjunction with distorted Born approximation (DBA), the transmit and receive antennas effects (i.e., polarization, orientation, height, etc.) are explicitly accounted for. Both the coherency nature of the model (joint phase and amplitude information) and the explicit account of system parameters (antenna, altitude, polarization, etc) enable one to perform various beamforming techniques to evaluate realistic deployment configurations. In this paper, several test scenarios will be presented and the results will be evaluated for feasibility for future biomass and root-zone soil moisture application using geostationary communication satellite signals of opportunity at low frequencies.

  20. The ultimatum game: Discrete vs. continuous offers

    Science.gov (United States)

    Dishon-Berkovits, Miriam; Berkovits, Richard

    2014-09-01

    In many experimental setups in social-sciences, psychology and economy the subjects are requested to accept or dispense monetary compensation which is usually given in discrete units. Using computer and mathematical modeling we show that in the framework of studying the dynamics of acceptance of proposals in the ultimatum game, the long time dynamics of acceptance of offers in the game are completely different for discrete vs. continuous offers. For discrete values the dynamics follow an exponential behavior. However, for continuous offers the dynamics are described by a power-law. This is shown using an agent based computer simulation as well as by utilizing an analytical solution of a mean-field equation describing the model. These findings have implications to the design and interpretation of socio-economical experiments beyond the ultimatum game.

  1. Postgraduates courses offered to nursing

    Directory of Open Access Journals (Sweden)

    Pedro Jorge Araujo

    2011-07-01

    Full Text Available Aim: To know the official masters that the Spanish Universities have offered during the academic course 2010/2011.Material and methods: Descriptive observational and transversal court study, in which it has analysed 170 university official masters and in which it has used a questionnaire with a total of 15 questions elaborated for this work.Results: 52 Spanish Universities of the 75 that there is have offered during the academic course 2010/2011 official masters that can realise for graduated in infirmary. By areas, the official masters more offered have been the ones of nutrition and alimentary security. 76,33% of the official masters have a length of 1 academic year. Almost the half of the official masters have an orientation researcher-professional and almost 40% researcher. 62,65% of the masters give of face-to-face way. In 52,1% of the official masters do not realise external practices and 86,2% has continuity with the doctorate.Conclusions: It has seen that it is necessary that expand the number of masters including other fields of study that contribute to a main specialisation of the professionals of the infirmary. An important percentage of official masters give in face-to-face modality, and there is very few offered on-line or to distance.

  2. Evapotranspiration and irrigation algorithms in hydrologic modeling:Present Status and Opportunities

    Science.gov (United States)

    Hydrologic models are used extensively for predicting water availability and water quality responses to alternative irrigation, tillage, crop, and fertilizer management practices and global climate change. Modeling results have been frequently used by regulatory agencies for developing remedial meas...

  3. Towards a predictive systems-level model of the human microbiome: progress, challenges, and opportunities.

    Science.gov (United States)

    Greenblum, Sharon; Chiu, Hsuan-Chao; Levy, Roie; Carr, Rogan; Borenstein, Elhanan

    2013-08-01

    The human microbiome represents a vastly complex ecosystem that is tightly linked to our development, physiology, and health. Our increased capacity to generate multiple channels of omic data from this system, brought about by recent advances in high throughput molecular technologies, calls for the development of systems-level methods and models that take into account not only the composition of genes and species in a microbiome but also the interactions between these components. Such models should aim to study the microbiome as a community of species whose metabolisms are tightly intertwined with each other and with that of the host, and should be developed with a view towards an integrated, comprehensive, and predictive modeling framework. Here, we review recent work specifically in metabolic modeling of the human microbiome, highlighting both novel methodologies and pressing challenges. We discuss various modeling approaches that lay the foundation for a full-scale predictive model, focusing on models of interactions between microbial species, metagenome-scale models of community-level metabolism, and models of the interaction between the microbiome and the host. Continued development of such models and of their integration into a multi-scale model of the microbiome will lead to a deeper mechanistic understanding of how variation in the microbiome impacts the host, and will promote the discovery of clinically relevant and ecologically relevant insights from the rich trove of data now available. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. INTERCULTURAL ISSUES OF THE TOURIST OFFER

    Directory of Open Access Journals (Sweden)

    Cristina Elena ALBU

    2015-03-01

    Full Text Available Tourism is an opportunity for people from different cultures to meet and interact, to exchange ideas, traditions and ways of thinking. In this industry it is very easy to judge a person just after taking an overall look and studying her general behavior. The aim of this article is to determine the intercultural issues that can show up during the tourist act, while people belonging to different cultures interact. The research method used for creating this article is documentary study. The tourist offer shall be adapted to different types of tourist, taking into consideration some aspects as tourists’ behavior, the type of tourism they prefer and, most of all, the culture they belong to and the culture of the people from the place they visit. Despite the immense diversity of our minds, there is a structure that can serve as a basis for mutual understanding.

  5. A model for the implementation of a two-shift municipal solid waste and recyclable material collection plan that offers greater convenience to residents.

    Science.gov (United States)

    Lin, Hung-Yueh; Tsai, Zong-Pei; Chen, Guan-Hwa; Kao, Jehng-Jung

    2011-01-01

    Separating recyclables from municipal solid waste (MSW) before collection reduces not only the quantity of MSW that needs to be treated but also the depletion of resources. However, the participation of residents is essential for a successful recycling program, and the level of participation usually depends on the degree of convenience associated with accessing recycling collection points. The residential accessing convenience (RAC) of a collection plan is determined by the proximity of its collection points to all residents and its temporal flexibility in response to resident requirements. The degree of proximity to all residents is determined by using a coverage radius that represents the maximum distance residents need to travel to access a recycling point. The temporal flexibility is assessed by the availability of proximal recycling points at times suitable to the lifestyles of all residents concerned. In Taiwan, the MSW collection is implemented at fixed locations and at fixed times. Residents must deposit their garbage directly into the collection vehicle. To facilitate the assignment of collection vehicles and to encourage residents to thoroughly separate their recyclables, in Taiwan MSW and recyclable materials are usually collected at the same time by different vehicles. A heuristic procedure including an integer programming (IP) model and ant colony optimization (ACO) is explored in this study to determine an efficient two-shift collection plan that takes into account RAC factors. The IP model has been developed to determine convenient collection points in each shift on the basis of proximity, and then the ACO algorithm is applied to determine the most effective routing plan of each shift. With the use of a case study involving a city in Taiwan, this study has demonstrated that collection plans generated using the above procedure are superior to current collection plans on the basis of proximity and total collection distance.

  6. Opportunities for Cross-Border Entrepreneurship Development in a Cluster Model Exemplified by the Polish–Czech Border Region

    Directory of Open Access Journals (Sweden)

    Joanna Kurowska-Pysz

    2016-03-01

    Full Text Available The subject of the paper is the analysis and evaluation of cross-border entrepreneurship development opportunities on the basis of cross-border cooperation, which has gradually evolved from consisting of bilateral partnerships to a networking model or even a cluster. The study conducted at the Polish–Czech border area indicates that, in terms of the development of cross-border cooperation, the economic sphere is lagging far behind social activities such as culture, education and tourism. At the same time, Polish and Czech enterprises are not sufficiently mobilized to develop cross-border entrepreneurship, although a number of support instruments in this regard have been proposed. Sustainable development of the border should take into account both social and economic aspects. An important research problem therefore becomes determining the possibility of boosting the development of cross-border entrepreneurship on the basis of the existing forms of cross-border cooperation, including cooperation in the social sphere. The aim of this paper is to define the conditions and opportunities for the development of cluster cooperation in the area of cross-border entrepreneurship. The author has attempted to resolve whether the intensity of cross-border cooperation can be a factor which mobilizes companies to develop their cross-border entrepreneurship and whether cross-border entrepreneurship can be further developed within the cluster model.

  7. Modelling the social and structural determinants of tuberculosis: opportunities and challenges.

    Science.gov (United States)

    Pedrazzoli, D; Boccia, D; Dodd, P J; Lönnroth, K; Dowdy, D W; Siroka, A; Kimerling, M E; White, R G; Houben, R M G J

    2017-09-01

    Despite the close link between tuberculosis (TB) and poverty, most mathematical models of TB have not addressed underlying social and structural determinants. To review studies employing mathematical modelling to evaluate the epidemiological impact of the structural determinants of TB. We systematically searched PubMed and personal libraries to identify eligible articles. We extracted data on the modelling techniques employed, research question, types of structural determinants modelled and setting. From 232 records identified, we included eight articles published between 2008 and 2015; six employed population-based dynamic TB transmission models and two non-dynamic analytic models. Seven studies focused on proximal TB determinants (four on nutritional status, one on wealth, one on indoor air pollution, and one examined overcrowding, socio-economic and nutritional status), and one focused on macro-economic influences. Few modelling studies have attempted to evaluate structural determinants of TB, resulting in key knowledge gaps. Despite the challenges of modelling such a complex system, models must broaden their scope to remain useful for policy making. Given the intersectoral nature of the interrelations between structural determinants and TB outcomes, this work will require multidisciplinary collaborations. A useful starting point would be to focus on developing relatively simple models that can strengthen our knowledge regarding the potential effect of the structural determinants on TB outcomes.

  8. Opportunities for computer abuse

    DEFF Research Database (Denmark)

    Willison, Robert Andrew; Backhouse, James

    2005-01-01

    Systems risk refers to the likelihood that an IS is inadequately guarded against certain types of damage or loss. While risks are posed by acts of God, hackers and viruses, consideration should also be given to the `insider' threat of dishonest employees, intent on undertaking some form of computer...... for the offender. To achieve this goal a model known as the `Crime Specific Opportunity Structure' is advanced. Focussing on the opportunities for computer abuse, the model addresses the nature of such opportunities with regards to the organisational context and the threats posed by rogue employees. Drawing...

  9. Opportunities for computer abuse

    DEFF Research Database (Denmark)

    Willison, Robert Andrew; Backhouse, James

    2005-01-01

    Systems risk refers to the likelihood that an IS is inadequately guarded against certain types of damage or loss. While risks are posed by acts of God, hackers and viruses, consideration should also be given to the `insider' threat of dishonest employees, intent on undertaking some form of computer...... for the offender. To achieve this goal a model known as the `Crime Specific Opportunity Structure' is advanced. Focussing on the opportunities for computer abuse, the model addresses the nature of such opportunities with regards to the organisational context and the threats posed by rogue employees. Drawing...

  10. Tools and Products of Real-Time Modeling: Opportunities for Space Weather Forecasting

    Science.gov (United States)

    Hesse, Michael

    2009-01-01

    The Community Coordinated Modeling Center (CCMC) is a US inter-agency activity aiming at research in support of the generation of advanced space weather models. As one of its main functions, the CCMC provides to researchers the use of space science models, even if they are not model owners themselves. The second CCMC activity is to support Space Weather forecasting at national Space Weather Forecasting Centers. This second activity involves model evaluations, model transitions to operations, and the development of draft Space Weather forecasting tools. This presentation will focus on the last element. Specifically, we will discuss present capabilities, and the potential to derive further tools. These capabilities will be interpreted in the context of a broad-based, bootstrapping activity for modern Space Weather forecasting.

  11. Research report on new business opportunities and models in Finnish biorefining industry; Biotuli. Selvitys bioliiketoiminnan uusista liiketoimintamahdollisuuksista ja -malleista

    Energy Technology Data Exchange (ETDEWEB)

    Hono, E.

    2013-11-01

    This report is a part of BIOTULI-project, which focuses on new products and business models for Finnish biorefining industry. The objective of this report is to review the business models required to capture value from the business opportunities discovered in BIOTULI-project. Report also aims to define the supply chain required for the business model and prerequisites for conducting profitable business in small and medium-scale enterprises. The report consists of two cases. Combining torrefaction with small-scale heat production and producing a biodegradable disinfectant with a new separation technique developed in BIOTULI-project. Research was conducted by literature review and interviews with experts from related fields. A business model was done for both cases. The execution and future developments of both business models were assessed. According to the analysis done for this report, combining torrefaction with a small-scale heat production is not profitable at moment. Possible changes in markets might make this business concept more lucrative in the future. The new biodegradable disinfectant has a significant commercial potential, but the research is still unfinished and it's too early to make an accurate evaluation of the business models profitability. Results of this paper can be used as a base for more comprehensive research projects regarding these business models. (orig.)

  12. Opportunities and challenges in supply-side simulation: physician-based models.

    Science.gov (United States)

    Gresenz, Carole Roan; Auerbach, David I; Duarte, Fabian

    2013-04-01

    To provide a conceptual framework and to assess the availability of empirical data for supply-side microsimulation modeling in the context of health care. Multiple secondary data sources, including the American Community Survey, Health Tracking Physician Survey, and SK&A physician database. We apply our conceptual framework to one entity in the health care market-physicians-and identify, assess, and compare data available for physician-based simulation models. Our conceptual framework describes three broad types of data required for supply-side microsimulation modeling. Our assessment of available data for modeling physician behavior suggests broad comparability across various sources on several dimensions and highlights the need for significant integration of data across multiple sources to provide a platform adequate for modeling. A growing literature provides potential estimates for use as behavioral parameters that could serve as the models' engines. Sources of data for simulation modeling that account for the complex organizational and financial relationships among physicians and other supply-side entities are limited. A key challenge for supply-side microsimulation modeling is optimally combining available data to harness their collective power. Several possibilities also exist for novel data collection. These have the potential to serve as catalysts for the next generation of supply-side-focused simulation models to inform health policy. © Health Research and Educational Trust.

  13. Opportunities and Challenges in Supply-Side Simulation: Physician-Based Models

    Science.gov (United States)

    Gresenz, Carole Roan; Auerbach, David I; Duarte, Fabian

    2013-01-01

    Objective To provide a conceptual framework and to assess the availability of empirical data for supply-side microsimulation modeling in the context of health care. Data Sources Multiple secondary data sources, including the American Community Survey, Health Tracking Physician Survey, and SK&A physician database. Study Design We apply our conceptual framework to one entity in the health care market—physicians—and identify, assess, and compare data available for physician-based simulation models. Principal Findings Our conceptual framework describes three broad types of data required for supply-side microsimulation modeling. Our assessment of available data for modeling physician behavior suggests broad comparability across various sources on several dimensions and highlights the need for significant integration of data across multiple sources to provide a platform adequate for modeling. A growing literature provides potential estimates for use as behavioral parameters that could serve as the models' engines. Sources of data for simulation modeling that account for the complex organizational and financial relationships among physicians and other supply-side entities are limited. Conclusions A key challenge for supply-side microsimulation modeling is optimally combining available data to harness their collective power. Several possibilities also exist for novel data collection. These have the potential to serve as catalysts for the next generation of supply-side-focused simulation models to inform health policy. PMID:23347041

  14. Reviewing the Role of Stakeholders in Operational Research: Opportunities for Group Model Building

    NARCIS (Netherlands)

    Gooyert, V. de; Rouwette, E.A.J.A.; Kranenburg, H.L. van

    2013-01-01

    Stakeholders have always received much attention in system dynamics, especially in the group model building tradition, which emphasizes the deep involvement of a client group in building a system dynamics model. In organizations, stakeholders are gaining more and more attention by managers who try t

  15. Cowichan Valley energy mapping and modelling. Report 3 - Analysis of potentially applicable distributed energy opportunities. Final report. [Vancouver Island, Canada

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-06-15

    The driving force behind the Integrated Energy Mapping and Analysis project was the identification and analysis of a suite of pathways that the Cowichan Valley Regional District (CVRD) can utilise to increase its energy resilience, as well as reduce energy consumption and GHG emissions, with a primary focus on the residential sector. Mapping and analysis undertaken will support provincial energy and GHG reduction targets, and the suite of pathways outlined will address a CVRD internal target that calls for 75% of the region's energy within the residential sector to come from locally sourced renewables by 2050. The target has been developed as a mechanism to meet resilience and climate action target. The maps and findings produced are to be integrated as part of a regional policy framework currently under development. The third task built upon the findings of the previous two and undertook an analysis of potentially applicable distributed energy opportunities. These opportunities were analysed given a number of different parameters, which were decided upon in consultation with the CVRD. The primary output of this task was a series of cost figures for the various technologies, thus allowing comparison on a cents/kWh basis. All of the cost figures from this task have been entered into a tailor made Excel model. This 'technology cost' model is linked to the Excel scenario model utilised in task 4. As a result, as technology costs change, they can be updated accordingly and be reflected in the scenarios. Please note, that the technologies considered at present in the technology cost model are well-proven technologies, available in the market today, even though the output is being used for an analysis of development until 2050. Task 3 results are detailed in this report and both presents an initial screening for various local renewable energies, and provides the CVRD with the means of evaluating the costs and benefits of local energy productions versus

  16. Using natural selection and optimization for smarter vegetation models - challenges and opportunities

    Science.gov (United States)

    Franklin, Oskar; Han, Wang; Dieckmann, Ulf; Cramer, Wolfgang; Brännström, Åke; Pietsch, Stephan; Rovenskaya, Elena; Prentice, Iain Colin

    2017-04-01

    Dynamic global vegetation models (DGVMs) are now indispensable for understanding the biosphere and for estimating the capacity of ecosystems to provide services. The models are continuously developed to include an increasing number of processes and to utilize the growing amounts of observed data becoming available. However, while the versatility of the models is increasing as new processes and variables are added, their accuracy suffers from the accumulation of uncertainty, especially in the absence of overarching principles controlling their concerted behaviour. We have initiated a collaborative working group to address this problem based on a 'missing law' - adaptation and optimization principles rooted in natural selection. Even though this 'missing law' constrains relationships between traits, and therefore can vastly reduce the number of uncertain parameters in ecosystem models, it has rarely been applied to DGVMs. Our recent research have shown that optimization- and trait-based models of gross primary production can be both much simpler and more accurate than current models based on fixed functional types, and that observed plant carbon allocations and distributions of plant functional traits are predictable with eco-evolutionary models. While there are also many other examples of the usefulness of these and other theoretical principles, it is not always straight-forward to make them operational in predictive models. In particular on longer time scales, the representation of functional diversity and the dynamical interactions among individuals and species presents a formidable challenge. Here we will present recent ideas on the use of adaptation and optimization principles in vegetation models, including examples of promising developments, but also limitations of the principles and some key challenges.

  17. Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling

    Directory of Open Access Journals (Sweden)

    Daniel R. Bayzigitov

    2016-01-01

    Full Text Available Fundamental studies of molecular and cellular mechanisms of cardiovascular disease pathogenesis are required to create more effective and safer methods of their therapy. The studies can be carried out only when model systems that fully recapitulate pathological phenotype seen in patients are used. Application of laboratory animals for cardiovascular disease modeling is limited because of physiological differences with humans. Since discovery of induced pluripotency generating induced pluripotent stem cells has become a breakthrough technology in human disease modeling. In this review, we discuss a progress that has been made in modeling inherited arrhythmias and cardiomyopathies, studying molecular mechanisms of the diseases, and searching for and testing drug compounds using patient-specific induced pluripotent stem cell-derived cardiomyocytes.

  18. Identifying Opportunities to Reduce Uncertainty in a National-Scale Forest Carbon Accounting Model

    Science.gov (United States)

    Shaw, C. H.; Metsaranta, J. M.; Kurz, W.; Hilger, A.

    2013-12-01

    Assessing the quality of forest carbon budget models used for national and international reporting of greenhouse gas emissions is essential, but model evaluations are rarely conducted mainly because of lack of appropriate, independent ground plot data sets. Ecosystem carbon stocks for all major pools estimated from data collected for 696 ground plots from Canada's new National Forest Inventory (NFI) were used to assess plot-level carbon stocks predicted by the Carbon Budget Model of the Canadian Forest Sector 3 (CBM-CFS3) -- a model compliant with the most complex (Tier-3) approach in the reporting guidelines of the Intergovernmental Panel on Climate Change. The model is the core of Canada's National Forest Carbon Monitoring, Accounting, and Reporting System. At the landscape scale, a major portion of total uncertainty in both C stock and flux estimation is associated with biomass productivity, turnover, and soil and dead organic matter modelling parameters, which can best be further evaluated using plot-level data. Because the data collected for the ground plots were comprehensive we were able to compare carbon stock estimates for 13 pools also estimated by the CBM-CFS3 (all modelled pools excepting coarse and fine root biomass) using the classical comparison statistics of mean difference and correlation. Using a Monte Carlo approach we were able to determine the contribution of aboveground biomass, deadwood and soil pool error to modeled ecosystem total error, as well as the contribution of pools that are summed to estimate aboveground biomass, deadwood and soil, to the error of these three subtotal pools. We were also able to assess potential sources of error propagation in the computational sequence of the CBM-CFS3. Analysis of the data grouped by the 16 dominant tree species allowed us to isolate the leading species where further research would lead to the greatest reductions in uncertainty for modeling of carbon stocks using the CBM-CFS3. This analysis

  19. MARK TWAIN SUMMER INSTITUTE, 1965 SESSION. GENERAL CATALOGUE OF INFORMATION AND COURSES OFFERED.

    Science.gov (United States)

    LEMEN, ROBERT F.

    THE MARK TWAIN SUMMER INSTITUTE OFFERED CHALLENGING EDUCATIONAL OPPORTUNITIES, PROVIDED EXCELLENT TEACHERS AN OPPORTUNITY TO DEVELOP NEW TECHNIQUES, AND OFFERED AN "INTERN-TEACHER" PROGRAM. THE STUDENTS QUALIFIED TO ATTEND WERE ABLE SECONDARY STUDENTS FROM GRADES 9 THROUGH 12. EACH STUDENT WOULD TAKE ONE NON-CREDIT HIGH SCHOOL COURSE. THE…

  20. Opportunities from low-resolution modelling of river morphology in remote parts of the world

    Science.gov (United States)

    Nones, M.; Guerrero, M.; Ronco, P.

    2014-01-01

    River morphodynamics are the result of a variety of processes, ranging from the typical small-scale of fluid mechanics (e.g. flow turbulence dissipation) to the large-scale of landscape evolution (e.g. fan deposition). However, problems inherent in the long-term modelling of large rivers derive from limited computational resources and the high level of process detail (i.e. spatial and temporal resolution). These modelling results depend on processes parameterization and calibrations based on detailed field data (e.g. initial morphology). Thus, for these cases, simplified tools are attractive. In this paper, a simplified 1-D approach is presented that is suited for modelling very large rivers. A synthetic description of the variations of cross-sections shapes is implemented on the basis of satellite images, typically also available for remote parts of the world. The model's flexibility is highlighted here by presenting two applications. In the first case, the model is used for analysing the long-term evolution of the lower Zambezi River (Africa) as it relates to the construction of two reservoirs for hydropower exploitation. In the second case, the same model is applied to study the evolution of the middle and lower Paraná River (Argentina), particularly in the context of climate variability. In both cases, having only basic data for boundary and initial conditions, the 1-D model provides results that are in agreement with past studies and therefore shows potential to be used to assist sediment management at the watershed scale or at boundaries of more detailed models.

  1. New opportunities for integrating mechanisms into soil carbon models for global simulations (Invited)

    Science.gov (United States)

    Torn, M. S.; Riley, W. J.; Contributions From: The Lake Constance Think Tank On Global Change; Feedback From Organic Carbon Dynamics-An Esf Workshop

    2010-12-01

    Numerical models of soil carbon cycling are being used to attribute carbon sinks, predict climate-ecosystem feedbacks, and evaluate climate mitigation strategies such as biofuels and sequestration. Current conceptions of SOC cycling and its expression in mathematical models rest heavily on the concept of recalcitrance - that some organic structures are intrinsically inert. However, recent research enabled by isotopic, spectroscopic, and molecular marker tools finds little evidence that recalcitrance, for example through selective preservation of plant derived material or resynthesis products, determines the long residence time of some OC in soils in a generalizable way. More likely, rates of carbon cycling are determined by the interaction of the organic matter and the soil environment including microorganisms, mineralogy, and climate. This does not mean compound chemistry is not important, rather that it does not act in isolation of other factors. Without the foundational principle that chemical composition defines the rate of decomposition, many tenets of old models are not supported, for example regarding decomposition response to change in temperature or plant species composition. Much progress could be made in the near term to improve soil carbon models by, for example, improving representations of oxygen diffusion and limitation, root carbon inputs, isotopic tracers, and making depth- or transport-related processes explicit. In other areas, new research is needed to translate recent findings into new parameters, for example, to replace texture with parameters for reactive mineral surface area to represent organo-mineral interaction. For the next generation of land model in the Community Earth System Model (was Community Climate System Model), we are developing new representations of many of these processes based on new data and understandings, to enable more accurate assessment of the vulnerability of soil organic carbon to predicted global climate change.

  2. Opportunities for improving animal welfare in rodent models of epilepsy and seizures.

    Science.gov (United States)

    Lidster, Katie; Jefferys, John G; Blümcke, Ingmar; Crunelli, Vincenzo; Flecknell, Paul; Frenguelli, Bruno G; Gray, William P; Kaminski, Rafal; Pitkänen, Asla; Ragan, Ian; Shah, Mala; Simonato, Michele; Trevelyan, Andrew; Volk, Holger; Walker, Matthew; Yates, Neil; Prescott, Mark J

    2016-02-15

    Animal models of epilepsy and seizures, mostly involving mice and rats, are used to understand the pathophysiology of the different forms of epilepsy and their comorbidities, to identify biomarkers, and to discover new antiepileptic drugs and treatments for comorbidities. Such models represent an important area for application of the 3Rs (replacement, reduction and refinement of animal use). This report provides background information and recommendations aimed at minimising pain, suffering and distress in rodent models of epilepsy and seizures in order to improve animal welfare and optimise the quality of studies in this area. The report includes practical guidance on principles of choosing a model, induction procedures, in vivo recordings, perioperative care, welfare assessment, humane endpoints, social housing, environmental enrichment, reporting of studies and data sharing. In addition, some model-specific welfare considerations are discussed, and data gaps and areas for further research are identified. The guidance is based upon a systematic review of the scientific literature, survey of the international epilepsy research community, consultation with veterinarians and animal care and welfare officers, and the expert opinion and practical experience of the members of a Working Group convened by the United Kingdom's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs).

  3. Outcomes and opportunities: a nurse-led model of chronic disease management in Australian general practice.

    Science.gov (United States)

    Eley, Diann S; Patterson, Elizabeth; Young, Jacqui; Fahey, Paul P; Del Mar, Chris B; Hegney, Desley G; Synnott, Robyn L; Mahomed, Rosemary; Baker, Peter G; Scuffham, Paul A

    2013-01-01

    The Australian government's commitment to health service reform has placed general practice at the centre of its agenda to manage chronic disease. Concerns about the capacity of GPs to meet the growing chronic disease burden has stimulated the implementation and testing of new models of care that better utilise practice nurses (PN). This paper reports on a mixed-methods study nested within a larger study that trialled the feasibility and acceptability of a new model of nurse-led chronic disease management in three general practices. Patients over 18 years of age with type 2 diabetes, hypertension or stable ischaemic heart disease were randomised into PN-led or usual GP-led care. Primary outcomes were self-reported quality of life and perceptions of the model's feasibility and acceptability from the perspective of patients and GPs. Over the 12-month study quality of life decreased but the trend between groups was not statistically different. Qualitative data indicate that the PN-led model was acceptable and feasible to GPs and patients. It is possible to extend the scope of PN care to lead the routine clinical management of patients' stable chronic diseases. All GPs identified significant advantages to the model and elected to continue with the PN-led care after our study concluded.

  4. The Spin-Charge-Family theory offers the explanation for all the assumptions of the Standard model, for the Dark matter, for the Matter-antimatter asymmetry, making several predictions

    CERN Document Server

    Borštnik, Norma Susana Mankoč

    2016-01-01

    The spin-charge-family theory, which is a kind of the Kaluza-Klein theories but with fermions carrying two kinds of spins (no charges), offers the explanation for all the assumptions of the standard model, with the origin of families, the higgs and the Yukawa couplings included. It offers the explanation also for other phenomena, like the origin of the dark matter and of the matter/antimatter asymmetry in the universe. It predicts the existence of the fourth family to the observed three, as well as several scalar fields with the weak and the hyper charge of the standard model higgs ($\\pm \\frac{1}{2}, \\mp \\frac{1}{2}$, respectively), which determine the mass matrices of family members, offering an explanation, why the fourth family with the masses above $1$ TeV contributes weakly to the gluon-fusion production of the observed higgs and to its decay into two photons, and predicting that the two photons events, observed at the LHC at $\\approx 750$ GeV, might be an indication for the existence of one of several s...

  5. Using occupancy and population models to assess habitat conservation opportunities for an isolated carnivore population

    Science.gov (United States)

    Wayne Spencer; Heather Rustigian-Romsos; James Strittholt; Robert Scheller; William Zielinski; Richard Truex

    2011-01-01

    An isolated population of the fisher (Martes pennanti) in the southern Sierra Nevada, California, is threatened by small size and habitat alteration from wildfires, fuels management, and other factors. We assessed the population’s status and conservation options for its habitat using a spatially explicit population model coupled with a...

  6. Meet the Molecules in Chocolate: Informal Opportunities for Building Thematic Molecular Models with Children

    Science.gov (United States)

    Amey, Jennifer R.; Fletcher, Matthew D.; Fletcher, Rachael V.; Jones, Alison; Roberts, Erica W.; Roberts, Ieuan O.

    2008-01-01

    We describe the development and use of a molecular model building activity with a chocolate theme, suitable for a public presentation of chemistry through interaction with visitors to science festivals and museums, and as a special classroom activity during science weeks, and so forth. (Contains 3 figures.)

  7. The Python Project: A Unique Model for Extending Research Opportunities to Undergraduate Students

    Science.gov (United States)

    Harvey, Pamela A.; Wall, Christopher; Luckey, Stephen W.; Langer, Stephen; Leinwand, Leslie A.

    2014-01-01

    Undergraduate science education curricula are traditionally composed of didactic instruction with a small number of laboratory courses that provide introductory training in research techniques. Research on learning methodologies suggests this model is relatively ineffective, whereas participation in independent research projects promotes enhanced…

  8. Incorporating Logistics in Freight Transport Demand Models: State-of-the-Art and Research Opportunities

    NARCIS (Netherlands)

    Tavasszy, L.A.; Ruijgrok, K.; Davydenko, I.

    2012-01-01

    Freight transport demand is a demand derived from all the activities needed to move goods between locations of production to locations of consumption, including trade, logistics and transportation. A good representation of logistics in freight transport demand models allows us to predict the effects

  9. Fundulus as the Premier Teleost Model in Environmental Biology: Opportunities for New Insights Using Genomics

    Science.gov (United States)

    A strong foundation of basic and applied research documents that the estuarine fish Fundulus heteroclitus and related species are unique laboratory and field models for understanding how individuals and populations interact with their environment. In this paper we summarize an ex...

  10. Method for identifying process reuse opportunities to enhance the operating model

    CSIR Research Space (South Africa)

    De Vries, M

    2011-12-01

    Full Text Available the volatility of strategy and suggests the use of an operating model (OM), which is a commitment to a way of doing business. The OM creates a company-wide vision for process standardization and data centralization and guides decisions about how a company...

  11. A window of opportunities : the contributions of land use modelling to societal learning

    NARCIS (Netherlands)

    Sterk, B.

    2007-01-01

    It has been argued that the management of land, whether at the field, farm or regional scale, can benefit from computer-based land use system analysis. As a result, a large number of computer-based models and tools have been produced over the past decades with the aim of providing support to policy

  12. Forest Conservation Opportunity Areas - Conservative Model (ECO_RES.COA_FORREST66)

    Science.gov (United States)

    This layer designates areas with potential for forest conservation. These are areas of natural or semi-natural forest land cover patches that area at least 395 meters away from roads and away from patch edges. OAs were modeled by creating distance grids using the National Land Cover Database and the Census Bureau's TIGER road files.

  13. Forest Conservation Opportunity Areas - Liberal Model (ECO_RES.COA_FORREST33)

    Science.gov (United States)

    This layer designates areas with potential for forest conservation. These are areas of natural or semi-natural forest land cover patches that are at least 75 meters away from roads and away from patch edges. OAs were modeled by creating distance grids using the National Land Cover Database and the Census Bureau's TIGER roads files.

  14. Meet the Molecules in Chocolate: Informal Opportunities for Building Thematic Molecular Models with Children

    Science.gov (United States)

    Amey, Jennifer R.; Fletcher, Matthew D.; Fletcher, Rachael V.; Jones, Alison; Roberts, Erica W.; Roberts, Ieuan O.

    2008-01-01

    We describe the development and use of a molecular model building activity with a chocolate theme, suitable for a public presentation of chemistry through interaction with visitors to science festivals and museums, and as a special classroom activity during science weeks, and so forth. (Contains 3 figures.)

  15. Sensitivity analysis in the WWTP modelling community – new opportunities and applications

    DEFF Research Database (Denmark)

    Sin, Gürkan; Ruano, M.V.; Neumann, Marc B.

    2010-01-01

    A mainstream viewpoint on sensitivity analysis in the wastewater modelling community is that it is a first-order differential analysis of outputs with respect to the parameters – typically obtained by perturbing one parameter at a time with a small factor. An alternative viewpoint on sensitivity ...

  16. The Python Project: A Unique Model for Extending Research Opportunities to Undergraduate Students

    Science.gov (United States)

    Harvey, Pamela A.; Wall, Christopher; Luckey, Stephen W.; Langer, Stephen; Leinwand, Leslie A.

    2014-01-01

    Undergraduate science education curricula are traditionally composed of didactic instruction with a small number of laboratory courses that provide introductory training in research techniques. Research on learning methodologies suggests this model is relatively ineffective, whereas participation in independent research projects promotes enhanced…

  17. A Modeling Framework for Supply Chain Simulation: Opportunities for Improved Decision Making

    NARCIS (Netherlands)

    Zee, van der D.J.; Vorst, van der J.G.A.J.

    2005-01-01

    Owing to its inherent modeling flexibility, simulation is often regarded as the proper means for supporting decision making on supply chain design. The ultimate success of supply chain simulation, however, is determined by a combination of the analyst's skills, the chain members' involvement, and th

  18. A modeling framework for supply chain simulation : opportunities for improved decision-making

    NARCIS (Netherlands)

    van der Zee, D.J.; van der Vorst, J.G.A.J.

    2005-01-01

    Owing to its inherent modeling flexibility, simulation is often regarded as the proper means for supporting decision making on supply chain design. The ultimate success of supply chain simulation, however, is determined by a combination of the analyst's skills, the chain members' involvement, and th

  19. Energy efficiency and renewable energy modeling with ETSAP TIAM - challenges, opportunities, and solutions

    DEFF Research Database (Denmark)

    Gregg, Jay Sterling; Balyk, Olexandr; Pérez, Cristian Hernán Cabrera

    The objectives of the Sustainable Energy for All (SE4ALL), a United Nations (UN) global initiative, are to achieve, by 2030: 1) universal access to modern energy services; 2) a doubling of the global rate of improvement in energy efficiency; and 3) a doubling of the share of renewable energy in t...... including updating data, setting constraints, and reporting on output. The presentation also addresses the addition of new model components such as traditional biomass and building energy efficiency....

  20. Modelling the migration opportunities of diadromous fish species along a gradient of dissolved oxygen concentration in a European tidal watershed

    Science.gov (United States)

    Maes, J.; Stevens, M.; Breine, J.

    2007-10-01

    The relationship between poor water quality and migration opportunities for fish remains poorly documented, although it is an essential research step in implementing EU water legislation. In this paper, we model the environmental constraints that control the movements of anadromous and catadromous fish populations that migrate through the tidal watershed of River Scheldt, a heavily impacted river basin in Western Europe. Local populations of sturgeon, sea lamprey, sea trout, Atlantic salmon, houting and allis shad were essentially extirpated around 1900. For remaining populations (flounder, three-spined stickleback, twaite shad, thinlip mullet, European eel and European smelt), a data driven logistic model was parameterized. The presence or absence of fish species in samples taken between 1995 and 2004 was modelled as a function of temperature, dissolved oxygen concentration, river flow and season. Probabilities to catch individuals from all diadromous species but three-spined stickleback increased as a function of the interaction between temperature and dissolved oxygen. The hypoxic zone situated in the freshwater tidal part of the estuary was an effective barrier for upstream migrating anadromous spawners since it blocked the entrance to historical spawning sites upstream. Similarly, habitat availability for catadromous fish was greatly reduced and restricted to lower brackish water parts of the estuary. The model was applied to infer preliminary dissolved oxygen criteria for diadromous fish, to make qualitative predictions about future changes in fish distribution given anticipated changes in water quality and to suggest necessary measures with respect to watershed management.

  1. Prospects and opportunities the implementation of effective management models at the enterprises of the Russian industry

    Directory of Open Access Journals (Sweden)

    E. S. Balashova

    2016-01-01

    Full Text Available In 2015 the recession of the Russian economy continues. Economic forecasts of 2016 made by influential rating agencies and the International Monetary Fund are analyzed. It is emphasized that the course of structural economic changes, selected by the Russian government actualizes the issue of increasing the competitiveness of Russian industry on a global level that, in turn, contributes to the implementation of effective management models at the enterprises and organization of internal processes. Positively recommended concept of lean production abroad became popular in Russia in early 2000’s. First successful example of its implementation – CJSC “Ford Motor Company” is considered. A large number of enterprises which represent state corporations “Rosteh” and “Rosatom”, industrial group “Basic element”, OJSC “Russian Railways” and which are individual major representatives of the Russian industrial sector are investigated. Different ways of development of lean production by Russian enterprises are analyzed and the most common way – independent interpretation and implementation is identified. Review of the tools of this management model used at the Russian enterprises is paid great attention. The prevalence of such tool as 5S (approximately 87,5%, because of its visible simplicity of understanding and ease of implementation is noted. The most important indicator – the economic effect of the introduction of the lean production concept at the enterprises of Russian industry in 2014 is analyzed. It is concluded that the economic result of the use of management model at Russian industrial enterprises is extremely low and varies at most about 1% of revenue. The obtained results demonstrate the prospects of further development of lean production and prove the possibility of achieving a high competitiveness of the domestic industrial sector of economy.

  2. Sustainable Global Competitiveness Model as a New Strategic Opportunity for the Companies in Slovakia

    Directory of Open Access Journals (Sweden)

    Šnircová Jana

    2016-05-01

    Full Text Available Dealing with global competitiveness is nowadays the strategic issue for the Slovak companies in context of sustainability. It means for managers of company to define new future strategic goals, to identify current position in global market, primarily to focus the strategy on sustainable global competitiveness and to assess the competitiveness in new way regarding sustainability and social corporate responsibility. The aim of this paper is to present the contribution to holistic micro and macro economical view on competitiveness of company in context of sustainable development in global environment. The introduced sustainable global competitiveness model is based on our experiences within the research in manufacturing companies in Slovakia. It is a visualization of enterprise as a system with all relation performing in its environment. Sustainable global competitiveness model comprises the three pillar principle of the sustainable development, modified Porter´s value chain, and economical environment represented with Global Competitiveness Index (GCI and other factors of environment which influence the company.

  3. Modeling Post-death Transmission of Ebola: Challenges for Inference and Opportunities for Control

    Science.gov (United States)

    Weitz, Joshua S.; Dushoff, Jonathan

    2015-03-01

    Multiple epidemiological models have been proposed to predict the spread of Ebola in West Africa. These models include consideration of counter-measures meant to slow and, eventually, stop the spread of the disease. Here, we examine one component of Ebola dynamics that is of ongoing concern - the transmission of Ebola from the dead to the living. We do so by applying the toolkit of mathematical epidemiology to analyze the consequences of post-death transmission. We show that underlying disease parameters cannot be inferred with confidence from early-stage incidence data (that is, they are not ``identifiable'') because different parameter combinations can produce virtually the same epidemic trajectory. Despite this identifiability problem, we find robustly that inferences that don't account for post-death transmission tend to underestimate the basic reproductive number - thus, given the observed rate of epidemic growth, larger amounts of post-death transmission imply larger reproductive numbers. From a control perspective, we explain how improvements in reducing post-death transmission of Ebola may reduce the overall epidemic spread and scope substantially. Increased attention to the proportion of post-death transmission has the potential to aid both in projecting the course of the epidemic and in evaluating a portfolio of control strategies.

  4. Moving forward in circles: Challenges and opportunities in modeling population cycles

    Science.gov (United States)

    Barraquand, Frederic; Louca, Stilianos; Abbott, Karen C; Cobbold, Christina A; Cordoleani, Flora; DeAngelis, Don; Elderd, Bret D; Fox, Jeremy W; Greenwood, Priscilla; Hilker, Frank M; Murray, Dennis; Stieha, Christopher R; Taylor, Rachel A; Vitense, Kelsey; Wolkowicz, Gail; Tyson, Rebecca C

    2017-01-01

    Population cycling is a widespread phenomenon, observed across a multitude of taxa in both laboratory and natural conditions. Historically, the theory associated with population cycles was tightly linked to pairwise consumer–resource interactions and studied via deterministic models, but current empirical and theoretical research reveals a much richer basis for ecological cycles. Stochasticity and seasonality can modulate or create cyclic behaviour in non-intuitive ways, the high-dimensionality in ecological systems can profoundly influence cycling, and so can demographic structure and eco-evolutionary dynamics. An inclusive theory for population cycles, ranging from ecosystem-level to demographic modelling, grounded in observational or experimental data, is therefore necessary to better understand observed cyclical patterns. In turn, by gaining better insight into the drivers of population cycles, we can begin to understand the causes of cycle gain and loss, how biodiversity interacts with population cycling, and how to effectively manage wildly fluctuating populations, all of which are growing domains of ecological research.

  5. Police Training in El Salvador: Challenges and Opportunities in Promoting the Community Police Model

    Directory of Open Access Journals (Sweden)

    Luisa Carolina Arévalo Herrera

    2014-05-01

    Full Text Available The Peace Accords emphasized creating a new police force that would be diametrically opposite to previous security forces. This change would have to be expressed symbolically, and from the onset it would have to underscore the fact that the main weapon of the police would be intelligence. From its foundation to June 2011, a total of 30,344 people have graduated from the Academy. Currently, in the process of training new police with greater quality, and modernizing the entire police force, it faces the difficult challenge of adopting the Community Police philosophy to empower this model for action, promoting a new relationship between community and law enforcement, and between managers and operational personnel in the agency. Nevertheless,police training is not enough if there are no significantchanges in the organizational climate and culture within the law enforcement agency.DOI: http://dx.doi.org/10.5377/rpsp.v1i1.1390

  6. Center for Semiconductor Materials and Device Modeling: expanding collaborative research opportunities between government, academia, and industry

    Science.gov (United States)

    Perconti, Philip; Bedair, Sarah S.; Bajaj, Jagmohan; Schuster, Jonathan; Reed, Meredith

    2016-09-01

    To increase Soldier readiness and enhance situational understanding in ever-changing and complex environments, there is a need for rapid development and deployment of Army technologies utilizing sensors, photonics, and electronics. Fundamental aspects of these technologies include the research and development of semiconductor materials and devices which are ubiquitous in numerous applications. Since many Army technologies are considered niche, there is a lack of significant industry investment in the fundamental research and understanding of semiconductor technologies relevant to the Army. To address this issue, the US Army Research Laboratory is establishing a Center for Semiconductor Materials and Device Modeling and seeks to leverage expertise and resources across academia, government and industry. Several key research areas—highlighted and addressed in this paper—have been identified by ARL and external partners and will be pursued in a collaborative fashion by this Center. This paper will also address the mechanisms by which the Center is being established and will operate.

  7. Environmental Modeling, The Buffer Priority layers for Phosphorus / Sediment) Removal identify priority forest/grass buffer opportunities by subwatershed. Land use, hydrology, soil, and landscape characteristics were analyzed to rank buffer opportunities with high P/sed removal., Published in 2014, Smaller than 1:100000 scale, Maryland Department of Natural Resources (DNR).

    Data.gov (United States)

    NSGIC Education | GIS Inventory — Environmental Modeling dataset current as of 2014. The Buffer Priority layers for Phosphorus / Sediment) Removal identify priority forest/grass buffer opportunities...

  8. Artificial intelligence and exponential technologies business models evolution and new investment opportunities

    CERN Document Server

    Corea, Francesco

    2017-01-01

    Artificial Intelligence is a huge breakthrough technology that is changing our world. It requires some degrees of technical skills to be developed and understood, so in this book we are going to first of all define AI and categorize it with a non-technical language. We will explain how we reached this phase and what historically happened to artificial intelligence in the last century. Recent advancements in machine learning, neuroscience, and artificial intelligence technology will be addressed, and new business models introduced for and by artificial intelligence research will be analyzed. Finally, we will describe the investment landscape, through the quite comprehensive study of almost 14,000 AI companies and we will discuss important features and characteristics of both AI investors as well as investments. This is the “Internet of Thinks” era. AI is revolutionizing the world we live in. It is augmenting the human experiences, and it targets to amplify human intelligence in a future not so distant from...

  9. The application of 3D cell models to support drug safety assessment: opportunities & challenges.

    Science.gov (United States)

    Roth, Adrian; Singer, Thomas

    2014-04-01

    The selection of drug candidates early in development has become increasingly important to minimize the use of animals and to avoid costly failures of drugs later in development. In vitro systems to predict and assess organ toxicity have so far been of limited value due to difficulties in demonstrating in vivo-relevant toxicity at a cell culture level. To overcome the limitations of single-cell type monolayer cultures and short-lived primary cell preparations, researchers have created novel 3-dimensional culture systems which appear to more closely resemble in vivo biology. These could become a key for the pharmaceutical industry in the evaluation of drug candidates. However, the value and acceptance of those new models in standard drug safety applications have yet to be demonstrated. This review aims to provide an overview of the different approaches undertaken in the field of pre-clinical safety assessment, organ toxicity, in particular, with an emphasis on examples and technical challenges. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Seizing Opportunity

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    After the remarkable progress of the past five years, China has entered its new five-year plan period, starting from 2006, aiming to further its economic and social development. Though some are still talking about "China threat," many others consider the country's growth a huge opportunity. In an interview with People's Daily, Bill Fischer, former President of the Sino-European International Business School in Shanghai, comments on China's current development and also talks about problems the country fac...

  11. Individual differences and the characterization of animal models of psychopathology: a strong challenge and a good opportunity

    Directory of Open Access Journals (Sweden)

    Antonio eArmario

    2013-11-01

    Full Text Available Despite the development of valuable new techniques (i.e. genetics, neuroimage for the study of the neurobiological substrate of psychiatric diseases, there are strong limitations in the information that can be gathered from human studies. It is thus critical to develop appropriate animal models of psychiatric diseases to characterize their putative biological bases and the development of new therapeutic strategies. The present review tries to offer a general perspective and several examples of how individual differences in animals can contribute to explain differential susceptibility to develop behavioural alterations, but also emphasizes methodological problems that can lead to inappropriate or over-simplistic interpretations. A critical analysis of the approaches currently used could contribute to obtain more reliable data and allow taking full advantage of new and sophisticated technologies. The discussion is mainly focused on anxiety-like and to a lower extent on depression-like behaviour in rodents.

  12. Evaluation of observed and modelled aerosol lifetimes using radioactive tracers of opportunity and an ensemble of 19 global models

    Science.gov (United States)

    Kristiansen, N. I.; Stohl, A.; Olivié, D. J. L.; Croft, B.; Søvde, O. A.; Klein, H.; Christoudias, T.; Kunkel, D.; Leadbetter, S. J.; Lee, Y. H.; Zhang, K.; Tsigaridis, K.; Bergman, T.; Evangeliou, N.; Wang, H.; Ma, P.-L.; Easter, R. C.; Rasch, P. J.; Liu, X.; Pitari, G.; Di Genova, G.; Zhao, S. Y.; Balkanski, Y.; Bauer, S. E.; Faluvegi, G. S.; Kokkola, H.; Martin, R. V.; Pierce, J. R.; Schulz, M.; Shindell, D.; Tost, H.; Zhang, H.

    2016-03-01

    Aerosols have important impacts on air quality and climate, but the processes affecting their removal from the atmosphere are not fully understood and are poorly constrained by observations. This makes modelled aerosol lifetimes uncertain. In this study, we make use of an observational constraint on aerosol lifetimes provided by radionuclide measurements and investigate the causes of differences within a set of global models. During the Fukushima Dai-Ichi nuclear power plant accident of March 2011, the radioactive isotopes cesium-137 (137Cs) and xenon-133 (133Xe) were released in large quantities. Cesium attached to particles in the ambient air, approximately according to their available aerosol surface area. 137Cs size distribution measurements taken close to the power plant suggested that accumulation-mode (AM) sulfate aerosols were the main carriers of cesium. Hence, 137Cs can be used as a proxy tracer for the AM sulfate aerosol's fate in the atmosphere. In contrast, the noble gas 133Xe behaves almost like a passive transport tracer. Global surface measurements of the two radioactive isotopes taken over several months after the release allow the derivation of a lifetime of the carrier aerosol. We compare this to the lifetimes simulated by 19 different atmospheric transport models initialized with identical emissions of 137Cs that were assigned to an aerosol tracer with each model's default properties of AM sulfate, and 133Xe emissions that were assigned to a passive tracer. We investigate to what extent the modelled sulfate tracer can reproduce the measurements, especially with respect to the observed loss of aerosol mass with time. Modelled 137Cs and 133Xe concentrations sampled at the same location and times as station measurements allow a direct comparison between measured and modelled aerosol lifetime. The e-folding lifetime τe, calculated from station measurement data taken between 2 and 9 weeks after the start of the emissions, is 14.3 days (95

  13. Evaluation of observed and modelled aerosol lifetimes using radioactive tracers of opportunity and an ensemble of 19 global models

    Directory of Open Access Journals (Sweden)

    N. I. Kristiansen

    2015-09-01

    Full Text Available Aerosols have important impacts on air quality and climate, but the processes affecting their removal from the atmosphere are not fully understood and are poorly constrained by observations. This makes modelled aerosol lifetimes uncertain. In this study, we make use of an observational constraint on aerosol lifetimes provided by radionuclide measurements and investigate the causes of differences within a set of global models. During the Fukushima Dai-Ichi nuclear power plant accident of March 2011, the radioactive isotopes cesium-137 (137Cs and xenon-133 (133Xe were released in large quantities. Cesium attached to particles in the ambient air, approximately according to their available aerosol surface area. 137Cs size distribution measurements taken close to the power plant suggested that accumulation-mode (AM sulphate aerosols were the main carriers for the cesium. Hence, 137Cs can be used as a proxy tracer for the AM sulphate aerosol's fate in the atmosphere. In contrast, the noble gas 133Xe behaves almost like a passive transport tracer. Global surface measurements of the two radioactive isotopes taken over several months after the release allow the derivation of a lifetime of the carrier aerosol. We compare this to the lifetimes simulated by 19 different atmospheric transport models initialized with identical emissions of 137Cs that were assigned to an aerosol tracer with each model's default properties of AM sulphate, and 133Xe emissions that were assigned to a passive tracer. We investigate to what extent the modelled sulphate tracer can reproduce the measurements, especially with respect to the observed loss of aerosol mass with time. Modelled 37Cs and 133Xe concentrations sampled at the same location and times as station measurements allow a direct comparison between measured and modelled aerosol lifetime. The e-folding lifetime τe, calculated from station measurement data taken between two and nine weeks after the start of the

  14. Marketing Digital Offerings Is Different: Strategies for Teaching about Digital Offerings in the Marketing Classroom

    Science.gov (United States)

    Roberts, Scott D.; Micken, Kathleen S.

    2015-01-01

    Digital offerings represent different challenges for marketers than do traditional goods and services. After reviewing the literature, the authors suggest ways that the marketing of digital goods and services might be better presented to and better understood by students. The well-known four challenges of services marketing model (e.g.,…

  15. Marketing Digital Offerings Is Different: Strategies for Teaching about Digital Offerings in the Marketing Classroom

    Science.gov (United States)

    Roberts, Scott D.; Micken, Kathleen S.

    2015-01-01

    Digital offerings represent different challenges for marketers than do traditional goods and services. After reviewing the literature, the authors suggest ways that the marketing of digital goods and services might be better presented to and better understood by students. The well-known four challenges of services marketing model (e.g.,…

  16. Modelling exposure opportunities

    DEFF Research Database (Denmark)

    Sabel, Clive E.; Gatrell, Anthony C.; Löytönen, Markku;

    2000-01-01

    emergence of the disease, with specific reference to the rare neurological condition, motor neurone disease (MND), using a dataset obtained from the Finnish Death Certificate registry, for MND deaths between the period 1985-1995. A space-time approach is adopted, whereby patterns in both time and space......This paper addresses the issues surrounding an individual's exposure to potential environmental risk factors, which can be implicated in the aetiology of a disease. We hope to further elucidate the 'lag' or latency period between the initial exposure to potential pathogens and the physical...

  17. Nanotechnology: Opportunities and Challenges

    Science.gov (United States)

    Meyyappan, Meyya

    2003-01-01

    Nanotechnology seeks to exploit novel physical, chemical, biological, mechanical, electrical, and other properties, which arise primarily due to the nanoscale nature of certain materials. A key example is carbon nanotubes (CNTs) which exhibit unique electrical and extraordinary mechanical properties and offer remarkable potential for revolutionary applications in electronics devices, computing, and data storage technology, sensors, composites, nanoelectromechanical systems (NEMS), and as tip in scanning probe microscopy (SPM) for imaging and nanolithography. Thus the CNT synthesis, characterization, and applications touch upon all disciplines of science and engineering. This presentation will provide an overview and progress report on this and other major research candidates in Nanotechnology and address opportunities and challenges ahead.

  18. Opportunities to enhance contribution of model forests in the sustainable forest resources management (example from Yalova Model Forest).

    Science.gov (United States)

    Bekiroğlu, Sultan; Özdemir, Mehmet; Özyürek, Ercan; Arslan, Avni

    2016-10-01

    Model forests are nongovernmental organizations at local, regional and international level which are mainly focused on reconciling the conflicts between the stakeholders. This is an innovative approach to organization, which has been receiving more and more attraction from increasing number of countries, which gradually increased the number of model forests for the last 25 years. If these organizations reach desired levels of structure, medium, impacts and assets their contribution in sustainable forest resources management will increase ipso facto. The very first model forest of Turkey was created in Yalova Province in 2010. Yalova Province has certain fundamental problems including but not limited to; population growth and unplanned urbanization caused by industrialization, uncontrolled increase in demand for fire wood and non-wooden products of forestry resources, questionable resource management decisions adopted in the past and low-income levels of the people especially those in the rural areas. The main objective of present case study is to analyze Yalova Model Forest (YMF) so as to determine the possible problems that may occur during implementation of sustainable management for forestry resources through a planning approach with multiple stakeholders. As a result of research, it has been revealed that YMF has certain significant structural, environmental and impact-related problems. In order to ensure continuity of YMF's contribution to sustainable forestry resources management, these problems need to be addressed promptly. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. 24 CFR 135.40 - Providing other economic opportunities.

    Science.gov (United States)

    2010-04-01

    ... EMPLOYMENT AND BUSINESS OPPORTUNITY ECONOMIC OPPORTUNITIES FOR LOW- AND VERY LOW-INCOME PERSONS Economic... economic opportunities offer an effective means of empowering low-income persons, a recipient is encouraged to undertake efforts to provide to low-income persons economic opportunities other than...

  20. Creating Innovative Opportunities

    DEFF Research Database (Denmark)

    Ljungberg, Daniel; McKelvey, Maureen; Lassen, Astrid Heidemann

    2012-01-01

    This paper develops lessons about how and why the founders and ventures involved in knowledge intensive entrepreneurship (KIE) manage the process of venture creation. The meta-analysis of the 86 case studies is based upon as conceptual model (from a systemic literature review), linked to illustra...... of knowledge networks to create innovative opportunities....

  1. A Spatially Based Area–Time Inundation Index Model Developed to Assess Habitat Opportunity in Tidal–Fluvial Wetlands and Restoration Sites

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, Andre M.; Diefenderfer, Heida L.; Ward, Duane L.; Borde, Amy B.

    2015-09-01

    The hydrodynamics of tidal wetland areas in the lower Columbia River floodplain and estuary directly affect habitat opportunity for endangered salmonid fishes. Physical and biological structures and functions in the system are directly affected by inundation patterns influenced by tidal cycles, hydropower operations, river discharge, upriver water withdrawals, climate, and physical barriers such as dikes, culverts, and tide gates. Ongoing ecosystem restoration efforts are intended to increase the opportunity for salmon to access beneficial habitats by hydrologically reconnecting main-stem river channels and diked areas within the historical floodplain. To address the need to evaluate habitat opportunity, a geographic information system-based Area-Time Inundation Index Model (ATIIM) was developed. The ATIIM integrates in situ or modeled hourly water-surface elevation (WSE) data and advanced terrain processing of high-resolution elevation data. The ATIIM uses a spatially based wetted-area algorithm to determine site average bankfull elevation, two- and three-dimensional inundation extent, and other site metrics. Hydrological process metrics such as inundation frequency, duration, maximum area, and maximum frequency area can inform evaluation of proposed restoration sites; e.g., determine trade-offs between WSE and habitat opportunity, contrast alternative restoration designs, predict impacts of altered flow regimes, and estimate nutrient and biomass fluxes. In an adaptive management framework, this model can be used to provide standardized site comparisons and effectiveness monitoring of changes in the developmental trajectories of restoration sites. Results are presented for 11 wetlands representative of tidal marshes, tidal forested wetlands, and restoration sites.

  2. Stakeholder Engagement/Capacity Building Pilot Opportunity FAQ

    Science.gov (United States)

    Frequently Asked Questions (FAQs) about the pilot opportunity for stakeholder engagement/capacity building. EPA is offering an opportunity for community stakeholders and ports to participate in a pilot project to test and refine capacity building tools.

  3. Water Technology Innovation: Ten Market Opportunities

    Science.gov (United States)

    The Water Technology Innovation Blueprint offers an overview of market opportunities that include conserving and recovering energy, recovering nutrients, improving water infrastructure, reducing costs for water monitoring, and improving water quality.

  4. 重度残障学生实施园区送教教学模式的探究%Exploration of a new teaching model of offering education services in living quarter for the students with severe disabilities

    Institute of Scientific and Technical Information of China (English)

    凌伟; 曾佳金; 张瑾; 冯莉青

    2015-01-01

    Objective:To research effectiveness of the teaching model of offering education services in living quarters, through implementing it to special children to ensure their educational rights in the compulsory education stage and improve their living abili-ties. Methods:The teaching forms like team intervention, group teaching, and individualized training were used to do the teaching study, and different teaching methods as guided teaching, games activities act, demonstration and operation and behavior modification were implied to offer the education services for the students in the living quarter. Before and after the teaching process, these students were evaluated. Results:After receiving the education in the living quarter for one semester, 22. 7 percent of the students were im-proved significantly in varying degrees, especially on movement ability, social skills and self-care ability. Conclusions:The teaching mode of offering the education services in the living quarters enables the students with severe disabilities to receive compulsory educa-tion, and to improve the survival and life quality.%目的::通过实施园区送教,保障义务教育阶段特殊儿童接受教育,提高生活能力,探究园区送教教学模式的有效性。方法:采用集体干预、小组教学及个别化训练的送教教学形式,运用引导式教学法、游戏活动法、演示与操作法和行为矫正法对园区送教的学生进行教学研究,并且在教学前后进行测评。结果:经过一学期的教学,22.7%学生在不同程度上有所提高,特别在运动能力、社会交往能力及生活自理能力上有较为显著的效果。结论:园区送教教学模式能使重度残障学生接受义务教育,较大限度地提高生存和生活质量。

  5. Physics Opportunities at the Next Generation of Precision Flavor Physics

    CERN Document Server

    Ciuchini, Marco

    2011-01-01

    Starting with next-generation experiments, flavor physics fully enters the era of precision measurements. The focus shifts from testing the Standard Model to finding and characterizing new physics contributions. We review the opportunities offered by future flavor experiments, discussing the expected sensitivities of the most important measurements. We also present some examples of measurable deviations from the Standard Model in the flavor sector generated in a selection of new physics models, demonstrating the major contribution that precision flavor physics could give to the effort of going beyond the Standard Model.

  6. THE ACCOUNTANT INFORMATION. DEMAND AND OFFER

    OpenAIRE

    Irina CHIRITA; Ioana ZAHEU

    2008-01-01

    The present paper is trying to correlate what Demand and Offer mean, from the economical point of view, which in the end tends towards the demand and offer of the accountant information. The objective of the demand and offer of accountant information is to promo te an efficient financial communication, objective that might be reached through the confrontation of the informational offer with the user’s demand. The information given by the enterprises are the basis of numerous economical and po...

  7. Determinants of High Schools' Advanced Course Offerings

    Science.gov (United States)

    Iatarola, Patrice; Conger, Dylan; Long, Mark C.

    2011-01-01

    This article examines the factors that determine a high school's probability of offering Advanced Placement (AP) and International Baccalaureate (IB) courses. The likelihood that a school offers advanced courses, and the number of sections that it offers, is largely driven by having a critical mass of students who enter high school with…

  8. The primary relevance of subconsciously offered attitudes

    DEFF Research Database (Denmark)

    Kristiansen, Tore

    2015-01-01

    ) and subconsciously (covertly) offered attitudes – because subconsciously offered attitudes appear to be a driving force in linguistic variation and change in a way that consciously offered attitudes are not. The argument is based on evidence from empirical investigations of attitudes and use in the ‘...

  9. Computer-Mediated Collaborative Projects as Professional Development Opportunities for Teachers

    Science.gov (United States)

    Shaughnessy, Julie; Purves, Ross; Jackson, Anita

    2008-01-01

    New technologies now offer teachers alternative models of collaboration with schools overseas, but how effective are they as professional development opportunities? The experiences of 18 specialist primary and secondary teachers in the Teachers' International Professional Development Programme who visited schools in the USA were investigated as…

  10. Computer-Mediated Collaborative Projects as Professional Development Opportunities for Teachers

    Science.gov (United States)

    Shaughnessy, Julie; Purves, Ross; Jackson, Anita

    2008-01-01

    New technologies now offer teachers alternative models of collaboration with schools overseas, but how effective are they as professional development opportunities? The experiences of 18 specialist primary and secondary teachers in the Teachers' International Professional Development Programme who visited schools in the USA were investigated as…

  11. Tecnologia e participação social no processo de produção e consumo de bens culturais: novas possibilidades trazidas pelas práticas letradas digitais mediadas pela Internet Technology and social participation in the process of production and consumption of cultural goods: new opportunities offered by digital literacy practices mediated by the Internet

    Directory of Open Access Journals (Sweden)

    Denise Bértoli Braga

    2010-12-01

    Full Text Available O presente artigo reflete sobre os limites sócio-estruturais que impedem a participação social mais ampla dos grupos economicamente desfavorecidos. O texto argumenta que, embora a Internet não garanta tal participação, ela propicia novos espaços para circulação social em práticas letradas diversas, inclusive aquelas de natureza hegemônica. Para ilustrar essa questão o artigo discute dados de uma entrevista realizada com um jovem líder que atua em uma comunidade localizada na periferia da cidade de Campinas, São Paulo. Os argumentos e colocações apresentados pelo entrevistado nos levam a refletir sobre a democratização dos modos de produção e consumo do conhecimento, em geral, e sobre a possibilidade de apropriação das TICs por comunidades periféricas, em particular.The present paper focuses on the limits socio-structurally imposed to exclude the social participation of economically disadvantaged groups in different spheres of cultural production and consumption. The paper argues that, although not guaranteeing new modes of participation, the Internet offers new virtual spaces that broaden the access to diversified ways of social circulation and participation in digital literacy practices, including those hegemonic in nature. To illustrate some of these major issues the study focuses on the data of an interview given by a young leader from a peripheral community located on the outskirts of the city of Campinas, São Paulo. The statements and arguments presented by the interviewee lead us to reflect on the process of democratization of knowledge production and consumption, in general, and about ICT appropriation by peripheral communities, in particular.

  12. A display model for the TOU of PLATO: just a cool toy or a benchmark of opportunities?

    Science.gov (United States)

    Dima, M.; Greggio, D.; Bergomi, M.; Biondi, F.; Farinato, J.; Farisato, G.; Magrin, D.; Lessio, L.; Marafatto, L.; Munari, M.; Pagano, I.; Ragazzoni, R.; Viotto, V.; Piazza, D.

    2016-07-01

    We produced a "toy-model" of one Telescope Optical Unit of PLATO, the Medium sized mission selected by ESA to fly in 2024. This is a six lenses dioptric very wide field camera with a window in front to take care of radiation impact on the first lens whose optical glass cannot be replaced with a radiation hardened one. The main aim of this project is just to produce a "cool" model for display purposes, in which one can "explore" the details of the inside through some openings in the tube, in order to visually inspect some of the fine details of the opto-mechanics. While its didactic and advertising role is out of doubt, during its construction we realized that some interesting outcome can be of some relevance for the project itself and that some findings could be useful, in order to assess the ability of producing with the same technology some (of course of much more modest quality) optical systems. In this context, we immediately dropped the option of producing the lenses with opaque material painted with a color resembling a refractive material (like blue for instance) and decided to actually produce them with transparent plastic. Furthermore the surfaces are then finely polished in order to give them basic optical properties. Such an optical system has only very coarsely the converging properties of the original nominal design for a number of reasons: the refractive indexes are not the nominal ones, the quality of the surfaces and their nominal values are only roughly, within a few percent, the targeted one, and the way the surfaces are built up makes them prone to some diffraction effects. However, the bulk of the lens and the surface roughness will give a large magnification of the scattering effects that will be experienced, at a much lower level, on the actual flight model. We investigated through propagation of a laser beam and by digital camera the main stray light modes that this toymodel offers. In other words, the model amplifies, to a large extent, the

  13. The role of ability, motivation, and opportunity to work in the transition from work to early retirement--testing and optimizing the Early Retirement Model.

    Science.gov (United States)

    de Wind, Astrid; Geuskens, Goedele A; Ybema, Jan Fekke; Bongers, Paulien M; van der Beek, Allard J

    2015-01-01

    Determinants in the domains health, job characteristics, skills, and social and financial factors may influence early retirement through three central explanatory variables, namely, the ability, motivation, and opportunity to work. Based on the literature, we created the Early Retirement Model. This study aims to investigate whether data support the model and how it could be improved. Employees aged 58-62 years (N=1862), who participated in the first three waves of the Dutch Study on Transitions in Employment, Ability and Motivation (STREAM) were included. Determinants were assessed at baseline, central explanatory variables after one year, and early retirement after two years. Structural equation modeling was applied. Testing the Early Retirement Model resulted in a model with good fit. Health, job characteristics, skills, and social and financial factors were related to the ability, motivation and/or opportunity to work (significant β range: 0.05-0.31). Lower work ability (β=-0.13) and less opportunity to work (attitude colleagues and supervisor about working until age 65: β=-0.24) predicted early retirement, whereas the motivation to work (work engagement) did not. The model could be improved by adding direct effects of three determinants on early retirement, ie, support of colleagues and supervisor (β=0.14), positive attitude of the partner with respect to early retirement (β=0.15), and not having a partner (β=-0.13). The Early Retirement Model was largely supported by the data but could be improved. The prolongation of working life might be promoted by work-related interventions focusing on health, work ability, the social work climate, social norms on prolonged careers, and the learning environment.

  14. Risk Measurement about Shanghai Interbank Offered Rate Based on GARCH Models%基于GARCH模型的上海同业拆借利率风险度量

    Institute of Scientific and Technical Information of China (English)

    房小定; 吕鹏

    2013-01-01

    In this paper, we make the overnight lending rate data of SHIBOR from October 8, 2006 to September 29, 2012 as an object for our study, useing VaR model to measure the Shanghai Interbank Offered Rate.We find GARCH (1,2)-GED distribution could characterize SHIBOR logarithmic distribution of daily return series betterly, in considering asymmetric rates tested, the EGARCH (1,2)-GED distribution can best portray SHIBOR logarithmic the distribution of daily return series and the estimated value of the asymmetric term is greater than zero and significant, indicating the presence of"anti-leverage effect", that is the impact of a negative impact for the interbank interest rate markets will cause greater volatility. Finally, we use the GARCH (1,2)-GED and EGARCH (1,2)-GED, respectively 95% and 99% confidence level to get VaR values about Shanghai interbank interest rate. Both models have passed the test back to test, and the models can be used to measure VaR values about the Shanghai interbank offered rate market.%  本文采用2006年10月8日至2012年9月29日的上海银行间同业拆借利率(SHIBOR)中的隔夜拆借利率数据作为研究对象,利用VaR模型对上海同业拆借利率进行度量,得出GARCH(1,2)-GED分布较好地刻画SHIBOR对数日收益率序列的分布,在考虑利率非对称性进行检验时,得出EGARCH(1,2)-GED分布最能刻画SHIBOR对数日收益率序列的分布,且非对称项的估计值为大于零且显著,表明存在“反杠杆效应”,即正的冲击比负的冲击会引起同业拆借利率市场更大的波动性。最后对GARCH(1,2)-GED与EGARCH(1,2)-GED分别在95%与99%的置信水平下得出上海同业拆借利率的VaR值。这两个模型都通过了模型回测检验,可用于测算上海银行间同业拆借利率市场对数收益率的风险价值。

  15. Marketing strategy to differentiate the offer

    OpenAIRE

    Miceski, Trajko; Pasovska, Silvana

    2013-01-01

    The marketing strategy for differentiation of the offers is important and accepted strategy especially by the bigger legal entities. The differentiation of the offers leads to bigger profit and bigger profitability in operation, through targeting of the demand towards the product of the enterprise. The vertical differentiation of the offers is directed towards the quality of the product itself which is observed as a something superior despite the competitive product which is observed as somet...

  16. Tourists’ expectations towards the agritourism farms’ offer

    Directory of Open Access Journals (Sweden)

    Iwona Wilk

    2013-06-01

    Full Text Available Agritourism plays an important role in multifunctional agriculture. Its development depends on agritourists’ needs identification in relation to the desired agritourism offer components which contributes to their improvement within agritourism farms market activity. The aim of the study was to determine customers preferences towards the agritourism farms offer in the Lodz region. The study was carried out on a sample of 120 respondents in 2011 (July-August and revealed that agritourists expect an offer, consisting of the components of various options offered by agritourism farm, matching their individual needs.

  17. Retirement Options to Offer College Faculty.

    Science.gov (United States)

    Felicetti, Daniel A.

    1982-01-01

    Retirement options available to institutions are outlined, including early retirement incentives, phased retirement, facilitating consulting opportunities, travel and outplacement services, maintaining community involvement, annuities, and pensions. Suggestions are made for increasing cost-effectiveness and fitting the options to local…

  18. Retirement Options to Offer College Faculty.

    Science.gov (United States)

    Felicetti, Daniel A.

    1982-01-01

    Retirement options available to institutions are outlined, including early retirement incentives, phased retirement, facilitating consulting opportunities, travel and outplacement services, maintaining community involvement, annuities, and pensions. Suggestions are made for increasing cost-effectiveness and fitting the options to local…

  19. Decision support for organ offers in liver transplantation.

    Science.gov (United States)

    Volk, Michael L; Goodrich, Nathan; Lai, Jennifer C; Sonnenday, Christopher; Shedden, Kerby

    2015-06-01

    Organ offers in liver transplantation are high-risk medical decisions with a low certainty of whether a better liver offer will come along before death. We hypothesized that decision support could improve the decision to accept or decline. With data from the Scientific Registry of Transplant Recipients, survival models were constructed for 42,857 waiting-list patients and 28,653 posttransplant patients from 2002 to 2008. Daily covariate-adjusted survival probabilities from these 2 models were combined into a 5-year area under the curve to create an individualized prediction of whether an organ offer should be accepted for a given patient. Among 650,832 organ offers from 2008 to 2013, patient survival was compared by whether the clinical decision was concordant or discordant with model predictions. The acceptance benefit (AB)--the predicted gain or loss of life by accepting a given organ versus waiting for the next organ--ranged from 3 to -22 years (harm) and varied geographically; for example, the average benefit of accepting a donation after cardiac death organ ranged from 0.47 to -0.71 years by donation service area. Among organ offers, even when AB was >1 year, the offer was only accepted 10% of the time. Patient survival from the time of the organ offer was better if the model recommendations and the clinical decision were concordant: for offers with AB > 0, the 3-year survival was 80% if the offer was accepted and 66% if it was declined (P decision support may improve patient survival in liver transplantation. © 2015 American Association for the Study of Liver Diseases.

  20. A ‘Smart’ Opportunity

    DEFF Research Database (Denmark)

    Breitenbauch, Henrik Ø.; Giegerich, Bastian

    2012-01-01

    cooperation, however, leads industry to think about cooperation mostly in terms of delays and market-distorting principles. With this backward-looking mindset, industry risks missing a crucial growth potential, a market that will only exist because of Smart Defense. Across the Atlantic, industry should seize...... this opportunity as eagerly as it would any good business development prospect. Simply put, the Smart Defense framework will offer a way to sell products that would not otherwise be sold....

  1. Development of an instrument to assess the impact of an enhanced experiential model on pharmacy students' learning opportunities, skills and attitudes: A retrospective comparative-experimentalist study

    Directory of Open Access Journals (Sweden)

    Collins John B

    2008-04-01

    Full Text Available Abstract Background Pharmacy schools across North America have been charged to ensure their students are adequately skilled in the principles and practices of pharmaceutical care. Despite this mandate, a large percentage of students experience insufficient opportunities to practice the activities, tasks and processes essential to pharmaceutical care. The objective of this retrospective study of pharmacy students was to: (1 as "proof of concept", test the overall educational impact of an enhanced advanced pharmacy practice experiential (APPE model on student competencies; (2 develop an instrument to measure students' and preceptors' experiences; and (3 assess the psychometric properties of the instrument. Methods A comparative-experimental design, using student and preceptor surveys, was used to evaluate the impact of the enhanced community-based APPE over the traditional APPE model. The study was grounded in a 5-stage learning model: (1 an enhanced learning climate leads to (2 better utilization of learning opportunities, including (3 more frequent student/patient consultation, then to (4 improved skills acquisition, thence to (5 more favorable attitudes toward pharmaceutical care practice. The intervention included a one-day preceptor workshop, a comprehensive on-site student orientation and extending the experience from two four-week experiences in different pharmacies to one eight-week in one pharmacy. Results The 35 student and 38 preceptor survey results favored the enhanced model; with students conducting many more patient consultations and reporting greater skills improvement. In addition, the student self-assessment suggested changes in attitudes favoring pharmaceutical care principles. Psychometric testing showed the instrument to be sensitive, valid and reliable in ascertaining differences between the enhanced and traditional arms. Conclusion The enhanced experiential model positively affects learning opportunities and competency

  2. 16 CFR 502.101 - Introductory offers.

    Science.gov (United States)

    2010-01-01

    ... FAIR PACKAGING AND LABELING ACT Retail Sale Price Representations § 502.101 Introductory offers. (a... retail sale at a price lower than the anticipated ordinary and customary retail sale price. (b) The... duration in excess of 6 months. (4) At the time of making the introductory offer promotion, the...

  3. 16 CFR 238.2 - Initial offer.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Initial offer. 238.2 Section 238.2 Commercial Practices FEDERAL TRADE COMMISSION GUIDES AND TRADE PRACTICE RULES GUIDES AGAINST BAIT ADVERTISING § 238.2 Initial offer. (a) No statement or illustration should be used in any advertisement...

  4. 7 CFR 3560.656 - Incentives offers.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Incentives offers. 3560.656 Section 3560.656... AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Housing Preservation § 3560.656 Incentives offers. (a....653(d), incentives to agree to the restrictive-use period in § 3560.662 if the following conditions...

  5. An offer you can’t refuse

    OpenAIRE

    Fletcher, Roland

    2001-01-01

    The general requirements of a valid contract must contain an offer, acceptance, consideration, intention, capacity and if necessary the correct formation, eg, does the contract have to be in writing. The focus of this article will be on offer, acceptance, consideration and an invitation to treat when dealing with contracts concluded during an auction.

  6. 17 CFR 230.252 - Offering statement.

    Science.gov (United States)

    2010-04-01

    ..., language and pagination. The requirements for offering statements are the same as those specified in § 230... Officer, a majority of the members of its board of directors or other governing body, and each selling... that contains the following language: This offering statement shall become qualified on the...

  7. Home-care companies' offerings take off.

    Science.gov (United States)

    Lutz, S

    1991-06-03

    Some home infusion therapy companies have been the beneficiaries of cash infusions thanks to the bullish reception of public offerings this year. The lucrative industry, reimbursed primarily by private payers and one of the fastest growing in healthcare, has long been a favorite on Wall Street. The companies plan to use proceeds from the successful offerings to pay off debt and finance expansion.

  8. Postdoctoral Opportunities and Career Options

    Science.gov (United States)

    Manka, R. H.

    2001-05-01

    Following the completion of a Ph.D. degree, in the sciences a postdoctoral appointment has traditionally been a key step in career development to expand the student's background and broaden their perspective. The postdoctoral appointment often is almost a requirement to obtain some positions in academia and government laboratories. In addition, postdoctoral positions in industry are becoming more common and offer an opportunity to explore a field without making a long-term commitment. We describe the nature of a postdoctoral appointment and discuss the advantages and disadvantages of the recent Ph.D. taking a postdoctoral position. We comment on the role such positions play in university, government and the corporate research. Finally, we describe some of the national postdoctoral opportunities that exist including large programs offered by the National Research Council through Federal laboratories including those of NASA, NOAA, EPA, and the Department of Defense. Exciting new interdisciplinary opportunities such as fellowships at the NASA Astrobiology Institute are summarized, as are international opportunities such as the von Humboldt fellowships in Germany.

  9. Perceived value creation process: focus on the company offer

    Directory of Open Access Journals (Sweden)

    Irena Pandža Bajs

    2012-12-01

    Full Text Available In the competitive business environment, as the number of rational consumers faced with many choices increases, companies can achieve their dominance best by applying the business concepts oriented to consumers in order to deliver a value which is different and better than that of their competitors. Among the various products on the market, an educated consumer chooses the offer that provides the greatest value for him/her. Therefore, it is essential for each company to determine how consumers perceive the value of its offer, and which factors determine the high level of perceived value for current and potential consumers. An analysis of these factors provides guidance on how to improve the existing offer and what the offer to be delivered in the future should be like. That could increase the perceived value of the company offer and result in a positive impact on consumer satisfaction and on establishing a stronger, longterm relationship with consumers. The process of defining the perceived value of a particular market offer is affected by the factors of the respective company’s offer as well as by competition factors, consumer factors and buying process factors. The aim of this paper is to analyze the relevant knowledge about the process of creating the perceived value of the company’s market offer and the factors that influence this process. The paper presents a conceptual model of the perceived value creation process in consumers’ mind.

  10. Comparison of patients' expectations and experiences at traditional pharmacies and pharmacies offering enhanced advanced pharmacy practice experiences.

    Science.gov (United States)

    Kassam, Rosemin; Collins, John B; Berkowitz, Jonathan

    2010-06-15

    To compare patients' expectations and experiences at pharmacies offering traditional APPE learning opportunities with those offering enhanced APPEs that incorporate pharmaceutical care activities. A survey of anchored measures of patient satisfaction was conducted in 2 groups of APPE- affiliated community pharmacies: those participating in an enhanced APPE model versus those participating in the traditional model. The enhanced intervention included preceptor training, a comprehensive student orientation, and an extended experience at a single pharmacy rather than the traditional 2 x 4-week experience at different pharmacies. While patient expectations were similar in both traditional and enhanced APPE pharmacies, patients in enhanced pharmacies reported significantly higher in-store satisfaction and fewer service gaps. Additionally, satisfaction was significantly higher for patients who had received any form of consultation, from either pharmacist or students, than those reporting no consultations. Including provision of pharmaceutical care services as part of APPEs resulted in direct and measurable improvements in patient satisfaction.

  11. Economic Dispatch of Demand Response Balancing through Asymmetric Block Offers

    DEFF Research Database (Denmark)

    O'Connell, Niamh; Pinson, Pierre; Madsen, Henrik

    2015-01-01

    load to provide a response to the power system and the subsequent need to recover. The conventional system dispatch algorithm is altered to facilitate the dispatch of demand response units alongside generating units using the proposed offer structure. The value of demand response is assessed through...... case studies that dispatch flexible supermarket refrigeration loads for the provision of regulating power. The demand resource is described by a set of asymmetric blocks, and a set of four blocks offers is shown to offer cost savings for the procurement of regulating power in excess of 20......%. For comparative purposes, the cost savings achievable with a fully observable and controllable demand response resource are evaluated, using a time series model of the refrigeration loads. The fully modeled resource offers greater savings; however the difference is small and potentially insufficient to justify...

  12. Snapshot of E-Commerce's Opportunities and Threats

    NARCIS (Netherlands)

    Saanen, Y. A.; Verbraeck, Alexander; Sol, H.G.

    1999-01-01

    E-commerce offers opportunities to change the way of doing business. However fully utilizing these opportunities and overcoming the bottlenecks, requires more than just getting online. The currently low Internet trade volumes confirm this. This paper gives a snapshot of opportunities and bottlenecks

  13. Snapshot of E-Commerce's Opportunities and Threats

    NARCIS (Netherlands)

    Saanen, Y. A.; Verbraeck, Alexander; Sol, H.G.

    1999-01-01

    E-commerce offers opportunities to change the way of doing business. However fully utilizing these opportunities and overcoming the bottlenecks, requires more than just getting online. The currently low Internet trade volumes confirm this. This paper gives a snapshot of opportunities and bottlenecks

  14. M.S. Offered in Industrial Chemistry

    Science.gov (United States)

    Chemical and Engineering News, 1975

    1975-01-01

    Describes graduate training geared specifically to prepare students for work in industry. Reports on schools offering such a program, and outlines the major characteristics of each school's curriculum. (GS)

  15. Mylan to Offer Generic EpiPen

    Science.gov (United States)

    ... news/fullstory_160669.html Mylan to Offer Generic EpiPen Manufacturer responds to mounting criticism about price hikes ... cheaper generic version of the emergency allergy treatment EpiPen will be made available within the next few ...

  16. Offering Spiritual Support for Family or Friends

    Science.gov (United States)

    Offering Spiritual Support for Family or Friends People who are very ill often ask spiritual questions, in seeking comfort, meaning and hope. While clergy, chaplains and other spiritual leaders may play an important role in spiritual ...

  17. Improving services for parents with psychiatric disabilities: three new opportunities in the field of psychiatric rehabilitation.

    Science.gov (United States)

    Cook, Judith A; Mueser, Kim T

    2014-03-01

    Despite many challenges, recent developments in the field of psychiatric rehabilitation offer opportunities for an increased focus on serving parents with psychiatric disabilities and their children. One such trend is the growth of psychosocial rehabilitation (PSR) programs that serve children and youth. The new Certificate in Children's Psychiatric Rehabilitation program offers practitioners education and training to meet the needs of children and families. Another opportunity can be found in the recent growth of family services in PSR programs for veterans with serious mental health problems. The Veterans Administration's new Psychosocial Rehabilitation and Recovery Services model explicitly includes family members in supporting veterans and acknowledges the need to deliver direct services to their spouses, children, and parents. A third relevant trend is the emergence of a new generation of recovery-oriented PSR services for mothers and fathers. Opportunities for enhanced services are provided in particular by self-help, peer support programs for parents with lived experience.

  18. Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs

    Directory of Open Access Journals (Sweden)

    Dubravka Svob Strac

    2016-11-01

    Full Text Available A large body of experimental and clinical evidence has strongly suggested that monoamines play an important role in regulating epileptogenesis, seizure susceptibility, convulsions and comorbid psychiatric disorders commonly seen in people with epilepsy. However, neither the relative significance of individual monoamines nor their interaction has yet been fully clarified due to the complexity of these neurotransmitter systems. In addition, epilepsy is diverse, with many different seizure types and epilepsy syndromes, and the role played by monoamines may vary from one condition to another. In this review, we will focus on the role of serotonin, dopamine, noradrenaline, histamine and melatonin in epilepsy. Recent experimental, clinical and genetic evidence, will be reviewed in consideration of the mutual relationship of monoamines with the other putative neurotransmitters. The complexity of epileptic pathogenesis may explain why the currently available drugs, developed according to the classic drug discovery paradigm of one-molecule-one-target, have turned out to be effective only in a percentage of people with epilepsy. Although no antiepileptic drugs currently target specifically monoaminergic systems, multi-target directed ligands acting on different monoaminergic proteins present on both neurons and glia cells may represent a new approach in the management of seizures and their generation as well as comorbid neuropsychiatric disorders.

  19. Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs

    OpenAIRE

    Dubravka Svob Strac; Nela Pivac; Ilse Julia Smolders; Wieslawa Agnieszka Fogel; Philippe De Deurwaerdere; Giuseppe Di Giovanni

    2016-01-01

    A large body of experimental and clinical evidence has strongly suggested that monoamines play an important role in regulating epileptogenesis, seizure susceptibility, convulsions and comorbid psychiatric disorders commonly seen in people with epilepsy. However, neither the relative significance of individual monoamines nor their interaction has yet been fully clarified due to the complexity of these neurotransmitter systems. In addition, epilepsy is diverse, with many different seizure types...

  20. Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs.

    Science.gov (United States)

    Svob Strac, Dubravka; Pivac, Nela; Smolders, Ilse J; Fogel, Wieslawa A; De Deurwaerdere, Philippe; Di Giovanni, Giuseppe

    2016-01-01

    A large body of experimental and clinical evidence has strongly suggested that monoamines play an important role in regulating epileptogenesis, seizure susceptibility, convulsions, and comorbid psychiatric disorders commonly seen in people with epilepsy (PWE). However, neither the relative significance of individual monoamines nor their interaction has yet been fully clarified due to the complexity of these neurotransmitter systems. In addition, epilepsy is diverse, with many different seizure types and epilepsy syndromes, and the role played by monoamines may vary from one condition to another. In this review, we will focus on the role of serotonin, dopamine, noradrenaline, histamine, and melatonin in epilepsy. Recent experimental, clinical, and genetic evidence will be reviewed in consideration of the mutual relationship of monoamines with the other putative neurotransmitters. The complexity of epileptic pathogenesis may explain why the currently available drugs, developed according to the classic drug discovery paradigm of "one-molecule-one-target," have turned out to be effective only in a percentage of PWE. Although, no antiepileptic drugs currently target specifically monoaminergic systems, multi-target directed ligands acting on different monoaminergic proteins, present on both neurons and glia cells, may represent a new approach in the management of seizures, and their generation as well as comorbid neuropsychiatric disorders.

  1. Internet-based self-management offers an opportunity to achieve better asthma control in adolescent

    NARCIS (Netherlands)

    Meer, V. van der; Stel, H.F. van; Detmar, S.B.; Otten, W.; Sterk, P.J.; Sont, J.K.

    2007-01-01

    Background: Internet and short message service are emerging tools for chronic disease management in adolescents, but few data exist on the barriers to and benefits of internet-based asthma self-management. Our objective was to reveal the barriers and benefits perceived by adolescents with well-contr

  2. Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs

    Science.gov (United States)

    Svob Strac, Dubravka; Pivac, Nela; Smolders, Ilse J.; Fogel, Wieslawa A.; De Deurwaerdere, Philippe; Di Giovanni, Giuseppe

    2016-01-01

    A large body of experimental and clinical evidence has strongly suggested that monoamines play an important role in regulating epileptogenesis, seizure susceptibility, convulsions, and comorbid psychiatric disorders commonly seen in people with epilepsy (PWE). However, neither the relative significance of individual monoamines nor their interaction has yet been fully clarified due to the complexity of these neurotransmitter systems. In addition, epilepsy is diverse, with many different seizure types and epilepsy syndromes, and the role played by monoamines may vary from one condition to another. In this review, we will focus on the role of serotonin, dopamine, noradrenaline, histamine, and melatonin in epilepsy. Recent experimental, clinical, and genetic evidence will be reviewed in consideration of the mutual relationship of monoamines with the other putative neurotransmitters. The complexity of epileptic pathogenesis may explain why the currently available drugs, developed according to the classic drug discovery paradigm of “one-molecule-one-target,” have turned out to be effective only in a percentage of PWE. Although, no antiepileptic drugs currently target specifically monoaminergic systems, multi-target directed ligands acting on different monoaminergic proteins, present on both neurons and glia cells, may represent a new approach in the management of seizures, and their generation as well as comorbid neuropsychiatric disorders. PMID:27891070

  3. Advanced phenotyping offers opportunities for improved breeding of forage and turf species

    DEFF Research Database (Denmark)

    Walter, Achim; Studer, Bruno; Kölliker, Roland

    2012-01-01

    Background and Aims Advanced phenotyping, i.e. the application of automated, high-throughput methods to characterize plant architecture and performance, has the potential to accelerate breeding progress but is far from being routinely used in current breeding approaches. In forage and turf...... improvement programmes, in particular, where breeding populations and cultivars are characterized by high genetic diversity and substantial genotype × environment interactions, precise and efficient phenotyping is essential to meet future challenges imposed by climate change, growing demand and declining...... resources. Scope This review highlights recent achievements in the establishment of phenotyping tools and platforms. Some of these tools have originally been established in remote sensing, some in precision agriculture, while others are laboratory-based imaging procedures. They quantify plant colour...

  4. Internet-based self-management offers an opportunity to achieve better asthma control in adolescent

    NARCIS (Netherlands)

    Meer, V. van der; Stel, H.F. van; Detmar, S.B.; Otten, W.; Sterk, P.J.; Sont, J.K.

    2007-01-01

    Background: Internet and short message service are emerging tools for chronic disease management in adolescents, but few data exist on the barriers to and benefits of internet-based asthma self-management. Our objective was to reveal the barriers and benefits perceived by adolescents with well-contr

  5. Opportunity Knocks: Pipeline Programs Offer Minority Students a Path to Dentistry

    Science.gov (United States)

    Fauteux, Nicole

    2012-01-01

    Minority students have traditionally been underrepresented in dental schools, which is why enrichment and pipeline programs aimed at helping minority students are necessary. That reality is reflected in their woeful underrepresentation among practicing dentists. Hispanics made up only 5.8 percent of practicing dentists in 2011, according to the…

  6. New opportunities offered by Cubesats for space research in Latin America: The SUCHAI project case

    Science.gov (United States)

    Diaz, M. A.; Zagal, J. C.; Falcon, C.; Stepanova, M.; Valdivia, J. A.; Martinez-Ledesma, M.; Diaz-Peña, J.; Jaramillo, F. R.; Romanova, N.; Pacheco, E.; Milla, M.; Orchard, M.; Silva, J.; Mena, F. P.

    2016-11-01

    During the last decade, a very small-standardized satellite, the Cubesat, emerged as a low-cost fast-development tool for space and technology research. Although its genesis is related to education, the change in paradigm presented by this satellite platform has motivated several countries, institutions, and companies to invest in a variety of technologies, aimed at improving Cubesat capabilities, while lowering costs of space missions. Following that trend, Latin American institutions, mostly universities, has started to develop Cubesat missions. This article describes some of the Latin American projects in this area. In particular, we discuss the achievements and scientific grounds upon which the first Cubesat projects in Chile were based and the implications that those projects have had on pursuing satellite-based research in the country and in collaboration with other countries of the region.

  7. FEDERAL CONTRACTING; Opportunities Exist to Increase Competition and Assess Reasons When Only One Offer Is Received

    Science.gov (United States)

    2010-07-01

    quickly. In the second example, at the Department of the Interior, the justification for a noncompetitive order on a GSA schedule contract to lease ...analysis and technical assistance support to provide a turnkey solution for operational support for services to the Foreign Terrorist Tracking Task

  8. Tuberculosis Immunity: Opportunities from Studies with Cattle

    Directory of Open Access Journals (Sweden)

    W. Ray Waters

    2011-01-01

    Full Text Available Mycobacterium tuberculosis and M. bovis share >99% genetic identity and induce similar host responses and disease profiles upon infection. There is a rich history of codiscovery in the development of control measures applicable to both human and bovine tuberculosis (TB including skin-testing procedures, M. bovis BCG vaccination, and interferon-γ release assays. The calf TB infection model offers several opportunities to further our understanding of TB immunopathogenesis. Recent observations include correlation of central memory immune responses with TB vaccine efficacy, association of SIRPα+ cells in ESAT-6:CFP10-elicited multinucleate giant cell formation, early γδ T cell responses to TB, antimycobacterial activity of memory CD4+ T cells via granulysin production, association of specific antibody with antigen burden, and suppression of innate immune gene expression in infected animals. Partnerships teaming researchers with veterinary and medical perspectives will continue to provide mutual benefit to TB research in man and animals.

  9. Opportunities in Martensite Theory

    OpenAIRE

    Olson, G.

    1995-01-01

    A workshop has explored interactions of materials science, applied mechanics, physics and mathematics in understanding fundamentals of martensitic transformations. System theory offers a framework for addressing realistic complexity. Theory of invariant-plane kinematics has been extended to multivariant plate groups and hierarchical structures. Electronic total energy calculations explore the origins of martensitic phase stability, and Landau-Ginzberg models for transformations with and witho...

  10. What One Physicist Has to Offer

    Science.gov (United States)

    Ross, Marc

    2004-05-01

    I was a particle theorist. In the early 1970s I began to analyze energy and its use in society. My theme is: What can physicists offer on a societal issue like energy? I have four topics: 1) Traffic safety and vehicle mass. The measurements are the record of some 40,000 deaths per year, vehicle characterizations and registrations. The statistical record is good, but information is lacking on physical processes in serious crashes. Our insight: while driver behavior is critical to safety, so is vehicle quality and design. Although one cannot definitively separate the injury impacts associated with momentum transfer from those due to intrusion, mass as such is not critical to safety. 2) Prospects for improving the energy efficiency of industrial processes. Our "measurements" were planning documents and interviews enabling us to analyze which "energy projects" were undertaken and which not. Insight: capital for projects was not allocated according to textbook economics; instead it was rationed. 3) Energy use by cars. Based on dynamometer studies motivated by the 1990 Clean Air Act Amendments, we created models of energy consumption that enable evaluation of modifications such as adopting a small engine while supplementing its capability for power. Insight: Vehicles could be designed to use much less fuel; but the gain for society is offset by low interest by new-car-buyers and manufacturers. 4) The effectiveness of automotive emissions controls. In addition to laboratory studies, we had surveys in "non-attainment" areas. Insight: Controls installed by original manufacturers are more robust and effective than repairs. Of the four, this is the one success for society. Conclusions: There are fascinating and solvable analytical challenges everywhere you look. But applications are hampered by the lack of a heritage and the close coupling between theorists and experimenters we know in physics.

  11. Vacancy Duration, Wage Offers, and Job Requirements

    DEFF Research Database (Denmark)

    Eriksson, Tor Viking; Chen, Long-Hwa

    Besides wage offers, credentials like education, work experience and skill requirements are key screening tools for firms in their recruitment of new employees. This paper adds some new evidence to a relatively tiny literature on firms' recruitment behaviour. In particular, our analysis...... is concerned with how vacancy durations vary with firms' minimum wage offers and minimum job requirements (regarding education, skills, age, gender and earlier work experience). The empirical analysis is based on ten employer surveys carried out by the DGBAS on Taiwan during the period 1996-2006. We estimate...... the business cycle. However, firms vary their skills requirements over the business cycle: our empirical analysis shows that, for a given wage offer, requirements are stricter in recessions and downturns. Separating between reasons for posting vacancies turned out important in explaining differences in vacancy...

  12. Product Offerings Testing through Customer Satisfaction

    Directory of Open Access Journals (Sweden)

    Tina Vukasovic

    2014-09-01

    Full Text Available Consumer satisfaction is imperative to a successful business, the reason for the choice of topic for this paper being explained thereby. Market changes have resulted in consumer’s enormous growth of power, which was recognized by many companies who adapted their business to meeting those expectations. Adaptation, however, also resulted in the need for constant measuring and evaluation. According to the above-mentioned, this paper measures consumer satisfaction with the product offer of the drugstore chain X The survey results have shown that X’s offer has not completely come up to the expectations of a smaller number of interviewees. In relation to the measuring ranks of consumer satisfaction defined, the greatest number of consumers has turned out to be satisfied with the product offer, whereas the percentage of those who find it excellent is smaller than the percentage of those who assess it as average.

  13. Wind offering in energy and reserve markets

    DEFF Research Database (Denmark)

    Soares, Tiago; Pinson, Pierre; Morais, Hugo

    2016-01-01

    their revenue, since currently wind turbine/farm technologies allow them to provide ancillary services. Thus, wind power producers are to develop offering strategies for participation in both energy and reserve markets, accounting for market rules, while ensuring optimal revenue. We consider a proportional...... offering strategy to optimally decide upon participation in both markets by maximizing expected revenue from day-ahead decisions while accounting for estimated regulation costs for failing to provide the services. An evaluation of considering the same proportional splitting of energy and reserve in both...

  14. Opportunity formation in social entrepreneurship

    DEFF Research Database (Denmark)

    Korsgaard, Steffen T.

    2011-01-01

    Purpose - This paper aims to explore the concept of opportunity and its role in social entrepreneurship processes. Design/methodology/approach - A single-case study of a sustainable community in Denmark. The data include interviews, documents and television programmes. Findings - The case study...... in the field of social entrepreneurship, while contributing to the development of the creation view of opportunities. Key words - Opportunity, Social entrepreneurship, Process, Sustainability, Case Study Paper type - Research paper...... finds that the opportunity takes a number of different forms in the process. These different forms are the result of a continuous mobilisation of actors. On the basis of these findings a model of social entrepreneurship processes is proposed, where the process is driven by mobilisation...

  15. Technology, Pedagogy, and Epistemology: Opportunities and Challenges of Using Computer Modeling and Simulation Tools in Elementary Science Methods

    Science.gov (United States)

    Schwarz, Christina V.; Meyer, Jason; Sharma, Ajay

    2007-01-01

    This study infused computer modeling and simulation tools in a 1-semester undergraduate elementary science methods course to advance preservice teachers' understandings of computer software use in science teaching and to help them learn important aspects of pedagogy and epistemology. Preservice teachers used computer modeling and simulation tools…

  16. Challenges and opportunities of the bio-pesticides production by solid-state fermentation: filamentous fungi as a model.

    Science.gov (United States)

    De la Cruz Quiroz, Reynaldo; Roussos, Sevastianos; Hernández, Daniel; Rodríguez, Raúl; Castillo, Francisco; Aguilar, Cristóbal N

    2015-01-01

    In recent years, production and use of bio-pesticides have increasing and replacing some synthetic chemical pesticides applied to food commodities. In this review, biological control is focused as an alternative, to some synthetic chemical treatments that cause environmental, human health, and food quality risks. In addition, several phytopathogenic microorganisms have developed resistance to some of these synthetic chemicals and become more difficult to control. Worldwide, the bio-pesticides market is growing annually at a rate of 44% in North America, 20% in Europe and Oceania, 10% in Latin and South American countries and 6% in Asia. Use of agro-industrial wastes and solid-state fermentation (SSF) technology offers an alternative to bio-pesticide production with advantages versus conventional submerged fermentations, as reduced cost and energy consumption, low production of residual water and high stability products. In this review, recent data about state of art regarding bio-pesticides production under SSF on agroindustrial wastes will be discussed. SSF can be defined as a microbial process that generally occurs on solid material in the absence of free water. This material has the ability to absorb water with or without soluble nutrients, since the substrate must have water to support the microorganism's growth and metabolism. Changes in water content are analyzed in order to select the conditions for a future process, where water stress can be combined with the best spore production conditions, obtaining in this way an inexpensive biotechnological option for modern agriculture in developing countries.

  17. Hair-offerings: an enigmatic Egyptian custom

    Directory of Open Access Journals (Sweden)

    G. J. Tassie

    1996-11-01

    Full Text Available The Egyptians did not record the reasons that lay behind the offering of hair. Using an holistic approach, which combines both ethnographic and ethnohistoric evidence, insights may be gained into the ancient remains of these rituals and practices.

  18. The timing of initial public offerings

    NARCIS (Netherlands)

    Benninga, Simon; Helmantel, Mark; Sarig, Oded

    2001-01-01

    Abstract In this paper, we study the dynamics of initial public offerings (IPOs) by examining the tradeoff between an entrepreneur’s private benefits, which are lost whenever the firm is publicly traded, versus the advantages from diversification. We characterize the timing dimension of the decision

  19. An Aging Workforce: Employment Opportunities and Obstacles

    Directory of Open Access Journals (Sweden)

    Full Professor, Institute of Economic Sciences

    2013-05-01

    Full Text Available The last decade has witnessed significant changes in the structure of unemployment in the global labour market. This is corroborated by the fact that the global workforce is rapidly aging and the share of people aged 50 and over in the structure of the labour market is increasing. In line with this trend, unemployment issues should be considered as a global problem that cannot be fully resolved at the level of any individual country separately.The main objective of this paper is to throw some light on the aging workforce and the elderly population’s opportunity to realise their right to work and be treated equally with younger age groups. Hence, the paper simultaneously focuses on the age and gender discrimination of elderly population in terms of their employment prospects. The aim of our research is not only to point out certain stereotypes concerning the elderly labour force, but also to stress that unless preconditions for overcoming these stereotypes are created and employment opportunities are given to this segment of the labour force, full employment as an ultimate goal of global economic policy cannot be achieved. It is in accordance with these considerations that we offer a model to achieve this goal.

  20. Modelling Growth Curves in a Nondescript Italian Chicken Breed: an Opportunity to Improve Genetic and Feeding Strategies

    National Research Council Canada - National Science Library

    Selvaggi, Maria; Laudadio, Vito; Dario, Cataldo; Tufarelli, Vincenzo

    2015-01-01

    ... it. This study was carried out to estimate the parameters of logistic, Gompertz and Richards growth curve models in a nondescript chicken breed population from southern Italy to determine the goodness of fit...

  1. ALINET: a model for assessing energy conservation opportunities in the food processing industry. Final technical report, September 1977-December 1979

    Energy Technology Data Exchange (ETDEWEB)

    Levis, A H; Ducot, E R; Levis, I S; Webster, T F

    1979-12-01

    ALINET is a network model designed for the analysis of energy use in the food processing and distribution sector and for the evaluation of the potential effectiveness of energy conserving technologies. The conceptual framework of the model, as well as the design and implementation of the computer software are described. The wheat system at the national, state, and facility-specific level is used to illustrate the model's operation and use. A pilot project, carried out in cooperation with industry, is described in which energy use in (a) hard wheat milling, and (b) durum milling and pasta manufacture is analyzed. Finally, the introduction of an alternative technology for pasta drying is assessed in terms of energy conservation and cost. Recommendation for further applications and institutionalization of the model are made.

  2. Missed opportunities in child healthcare

    Directory of Open Access Journals (Sweden)

    Linda Jonker

    2014-01-01

    Full Text Available Background: Various policies in health, such as Integrated Management of Childhood Illnesses, were introduced to enhance integrated service delivery in child healthcare. During clinical practice the researcher observed that integrated services may not be rendered.Objectives: This article describes the experiences of mothers that utilised comprehensive child health services in the Cape Metropolitan area of South Africa. Services included treatment for diseases; preventative interventions such as immunisation; and promotive interventions, such as improvement in nutrition and promotion of breastfeeding.Method: A qualitative, descriptive phenomenological approach was applied to explore the experiences and perceptions of mothers and/or carers utilising child healthcare services. Thirty percent of the clinics were selected purposively from the total population. A convenience purposive non-probability sampling method was applied to select 17 mothers who met the criteria and gave written consent. Interviews were conducted and recorded digitally using an interview guide. The data analysis was done using Tesch’s eight step model.Results: Findings of the study indicated varied experiences. Not all mothers received information about the Road to Health book or card. According to the mothers, integrated child healthcare services were not practised. The consequences were missed opportunities in immunisation, provision of vitamin A, absence of growth monitoring, feeding assessment and provision of nutritional advice.Conclusion: There is a need for simple interventions such as oral rehydration, early recognition and treatment of diseases, immunisation, growth monitoring and appropriate nutrition advice. These services were not offered diligently. Such interventions could contribute to reducing the incidence of child morbidity and mortality.

  3. UTBB FDSOI: Evolution and opportunities

    Science.gov (United States)

    Monfray, Stephane; Skotnicki, Thomas

    2016-11-01

    As today's 28 nm FDSOI (Fully Depleted Silicon On Insulator) technology is at the industrialization level, this paper aims to summarize the key advantages allowed by the thin BOX (Buried Oxide) of the FDSOI, through the technology evolution but also new opportunities, among logic applications and extending the possibilities offered by the platform. We will summarize how the advantages provided by the thin BOX have been first explored and developed, and how the back biasing techniques are the key to the outstanding performances provided by the FDSOI at low voltage. Then, as the FDSOI technology is also a solution to develop innovative platforms and applications, we will detail some opportunities. In particular, we will present monolithic 3D integration, ultra-low power devices for IoT (Internet of Things) and ultra-sensitive sensors.

  4. Equal opportunity in the workplace.

    Science.gov (United States)

    Allen, A

    1992-04-01

    The Equal Employment Opportunity Commission (EEOC) was created by the Civil Rights Act of 1964. The commission encourages voluntary compliance with equal employment opportunity practices, and has authority to investigate complaints alleging discrimination in hiring, firing, wage rates, testing, training, apprenticeship, and other conditions of employment. In October 1991, during the Senate Judiciary Committee hearings, the confirmation of Judge Clarence Thomas for a seat on the United States Supreme Court was placed in jeopardy by a charge of sexual harassment while Thomas was head of the EEOC. This article focuses on aspects of sexual harassment in the workplace, the role of the EEOC, and offers some suggestions for keeping the work environment free of abusive behavior.

  5. Integrating a Detailed Agricultural Model in a Global Economic Framework: New methods for assessment of climate mitigation and adaptation opportunities

    Science.gov (United States)

    Thomson, A. M.; Izaurralde, R. C.; Calvin, K.; Zhang, X.; Wise, M.; West, T. O.

    2010-12-01

    Climate change and food security are global issues increasingly linked through human decision making that takes place across all scales from on-farm management actions to international climate negotiations. Understanding how agricultural systems can respond to climate change, through mitigation or adaptation, while still supplying sufficient food to feed a growing global population, thus requires a multi-sector tool in a global economic framework. Integrated assessment models are one such tool, however they are typically driven by historical aggregate statistics of production in combination with exogenous assumptions of future trends in agricultural productivity; they are not yet capable of exploring agricultural management practices as climate adaptation or mitigation strategies. Yet there are agricultural models capable of detailed biophysical modeling of farm management and climate impacts on crop yield, soil erosion and C and greenhouse gas emissions, although these are typically applied at point scales that are incompatible with coarse resolution integrated assessment modeling. To combine the relative strengths of these modeling systems, we are using the agricultural model EPIC (Environmental Policy Integrated Climate), applied in a geographic data framework for regional analyses, to provide input to the global economic model GCAM (Global Change Assessment Model). The initial phase of our approach focuses on a pilot region of the Midwest United States, a highly productive agricultural area. We apply EPIC, a point based biophysical process model, at 60 m spatial resolution within this domain and aggregate the results to GCAM agriculture and land use subregions for the United States. GCAM is then initialized with multiple management options for key food and bioenergy crops. Using EPIC to distinguish these management options based on grain yield, residue yield, soil C change and cost differences, GCAM then simulates the optimum distribution of the available

  6. Does gold offer a better protection against sovereign debt crisis than other metals?

    OpenAIRE

    Agyei-Ampomah, Sam; Gounopoulos, Dimitrios; Mazouz, Khelifa

    2014-01-01

    It is a commonly held view that gold protects investors’ wealth in the event of negative economic conditions. In this study, we test whether other metals offer similar or better investment opportunities in periods of market turmoil. Using a sample of 13 sovereign bonds, we show that other precious metals, palladium in particular, offer investors greater compensation for their bond market losses than gold. We also find that industrial metals, especially copper, tend to outperform gold and othe...

  7. Offering Behavioral Assistance to Latino Students Demonstrating Challenging Behaviors

    Directory of Open Access Journals (Sweden)

    Gerardo Moreno

    2015-11-01

    Full Text Available Challenging behaviors can significantly alter the learning environment of any classroom. Traditionally, schools have implemented practices that remove the offending student from the classroom, deliver punitive disciplinary actions, or refer the student to special education evaluation. Unfortunately, such practices have demonstrated little longitudinal effectiveness, with detrimental outcomes for the referred student, particularly students from Latino backgrounds. With enrollment projections indicating Latinos will become the majority in U.S. schools, educators are presented with the opportunity to shift away from past practices and implement evidence-based practices that concurrently assist students while addressing challenging behaviors. In this paper, the authors discuss past disciplinary practices, the adverse effects on Latino students, and offer recommendations on implementing functional behavioral assessment as a means to better meet the needs of Latino students demonstrating challenging behaviors.

  8. Service Offering at Electrical Equipment Manufacturers

    Directory of Open Access Journals (Sweden)

    Lucie Kaňovská

    2015-09-01

    Full Text Available Purpose of the article: The aim of the paper is to uncover ways of managing service offering provid-ed by electrical equipment manufactures in the Czech Republic. The segment is extremely important for Czech industry nowadays, especially because of many companies being subcontractors for the car industry and mechanical engineering. The producers of electric equipment comply with the Czech in-dustry classification CZ-NACE 27. Methodology/methods: The questionnaire in the form of the Likert scale was prepared to gather in-formation about customer services. The respondents were usually directors or managers, e.g. employ-ees with high competencies of knowing customer services in this particular market. The total of 22 companies were included in the survey. Research was focused on the following industries classifica-tions belonging to CZ-NACE 27: CZ-NACE 27, CZ-NACE 271 and CZ-NACE 273. According to Czech Statistical Office the total number of companies belonging to these 3 segments is 136. It means 16,2 % companies belonging to CZ-NACE 27 participated in our research. Basic statistical methods were used to analyse the complete database. Scientific aim: The paper deals with the problem of service offering provided by today’s manufactur-ers. Global understanding of services that manufacturers really develop, sell, deliver and manage is still limited. Findings: Managing service offering provided by today‘s manufacturers shows that 1 Manufacturers not offer only tangible products, but also wide range of services and even information and support. 2 New products are not designed only according to company technicians, but also according to their cus-tomers. Their products and services are developed, tested and improved according to their needs. 3 Services provide complex customer care from time product selection to its end. Conclusions: Manufacturers of tangible products need to enlarge their product offering to be able to satisfy customers. Therefore

  9. Modeling and Simulation of Scalable Cloud Computing Environments and the CloudSim Toolkit: Challenges and Opportunities

    CERN Document Server

    Buyya, Rajkumar; Calheiros, Rodrigo N

    2009-01-01

    Cloud computing aims to power the next generation data centers and enables application service providers to lease data center capabilities for deploying applications depending on user QoS (Quality of Service) requirements. Cloud applications have different composition, configuration, and deployment requirements. Quantifying the performance of resource allocation policies and application scheduling algorithms at finer details in Cloud computing environments for different application and service models under varying load, energy performance (power consumption, heat dissipation), and system size is a challenging problem to tackle. To simplify this process, in this paper we propose CloudSim: an extensible simulation toolkit that enables modelling and simulation of Cloud computing environments. The CloudSim toolkit supports modelling and creation of one or more virtual machines (VMs) on a simulated node of a Data Center, jobs, and their mapping to suitable VMs. It also allows simulation of multiple Data Centers to...

  10. Master classes - What do they offer?

    OpenAIRE

    Hanken, Ingrid Maria; Long, Marion

    2012-01-01

    Master classes are a common way to teach music performance, but how useful are they in helping young musicians in their musical development? Based on his experiences of master classes Lali (2003:24) states that “For better or for worse, master classes can be life-changing events.” Anecdotal evidence confirm that master classes can provide vital learning opportunities, but also that they can be of little use to the student, or worse, detrimental. Since master classes are a common component in ...

  11. FOREIGN LANGUAGE PROGRAMS OFFERED IN TURKISH UNIVERSITIES

    Directory of Open Access Journals (Sweden)

    Bengül CETINTAS

    2016-10-01

    Full Text Available n this study, the departments of philology and teaching, which take place in higher education programs in Turkey and give education in foreign language, have been examined. 23 different languages are offered to philology students who wants to attend to faculty of literature. Students can prefer classical languages besides modern languages. However, English, German, French, Arabic and Japanese are offered to the students of teaching department. To teach another foreign language, pedagogical formation is also required.This study focuses on the departments of German Language Teaching and German Language and Literature. From this point, the place and the importance of other philology and foreign language teaching departments in Turkish higher education have been examined.

  12. Internal steam reforming in solid oxide fuel cells: Status and opportunities of kinetic studies and their impact on modelling

    DEFF Research Database (Denmark)

    Mogensen, David; Grunwaldt, J.-D.; Hendriksen, Peter Vang;

    2011-01-01

    of such a system require SOFC models that include accurate description of the steam reforming rate. The objective of this article is to review the reported kinetic expressions for the steam reforming reaction. Extensive work has been performed on traditional catalysts for steam reforming. Because of differences...

  13. The effects of the use of a conversational model and opportunities for reflections in computer-based role playing

    NARCIS (Netherlands)

    Holsbrink-Engels, Geralien A.

    1997-01-01

    This study examined the effects of an instructional program on 21-year-old students' interpersonal skills development (N = 104). The HyperCard 2.1 program ¿Telling bad news¿ could contain a conversational model that informed students about the main moments and actions in conducting a bad-news conver

  14. Rewriting the Opportunity Theory

    DEFF Research Database (Denmark)

    Korsgaard, Steffen T.

    The aim of this paper is to further the discussion of opportunity theory by discussing its ontological and epistemological underpinnings, which have been neglected in previous discussions. The idea that opportunities have an objective component is critically examined drawing on insights from social...... constructionism. It is argued that opportunity theory needs to be rewritten....

  15. Opportunity Cost: A Reexamination

    Science.gov (United States)

    Parkin, Michael

    2016-01-01

    Is opportunity cost an ambiguous and arbitrary concept or a simple, straightforward, and fruitful one? This reexamination of opportunity cost addresses this question, and shows that opportunity cost is an ambiguous concept because "two" definitions are in widespread use. One of the definitions is indeed simple, fruitful, and one that…

  16. Rewriting the Opportunity Theory

    DEFF Research Database (Denmark)

    Korsgaard, Steffen T.

    The aim of this paper is to further the discussion of opportunity theory by discussing its ontological and epistemological underpinnings, which have been neglected in previous discussions. The idea that opportunities have an objective component is critically examined drawing on insights from social...... constructionism. It is argued that opportunity theory needs to be rewritten....

  17. Human pluripotent stem cell models of autism spectrum disorder: emerging frontiers, opportunities, and challenges towards neuronal networks in a dish

    OpenAIRE

    Aigner, Stefan; Heckel, Tobias; Zhang, Jitao D.; Andreae, Laura C.; Jagasia, Ravi

    2013-01-01

    Autism spectrum disorder (ASD) is characterized by deficits in language development and social cognition and the manifestation of repetitive and restrictive behaviors. Despite recent major advances, our understanding of the pathophysiological mechanisms leading to ASD is limited. Although most ASD cases have unknown genetic underpinnings, animal and human cellular models of several rare, genetically defined syndromic forms of ASD have provided evidence for shared pathophysiological mechanisms...

  18. A multi-scale mathematical modeling framework to investigate anti-viral therapeutic opportunities in targeting HIV-1 accessory proteins.

    Science.gov (United States)

    Suryawanshi, Gajendra W; Hoffmann, Alexander

    2015-12-07

    Human immunodeficiency virus-1 (HIV-1) employs accessory proteins to evade innate immune responses by neutralizing the anti-viral activity of host restriction factors. Apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G, A3G) and bone marrow stromal cell antigen 2 (BST2) are host resistance factors that potentially inhibit HIV-1 infection. BST2 reduces viral production by tethering budding HIV-1 particles to virus producing cells, while A3G inhibits the reverse transcription (RT) process and induces viral genome hypermutation through cytidine deamination, generating fewer replication competent progeny virus. Two HIV-1 proteins counter these cellular restriction factors: Vpu, which reduces surface BST2, and Vif, which degrades cellular A3G. The contest between these host and viral proteins influences whether HIV-1 infection is established and progresses towards AIDS. In this work, we present an age-structured multi-scale viral dynamics model of in vivo HIV-1 infection. We integrated the intracellular dynamics of anti-viral activity of the host factors and their neutralization by HIV-1 accessory proteins into the virus/cell population dynamics model. We calculate the basic reproductive ratio (Ro) as a function of host-viral protein interaction coefficients, and numerically simulated the multi-scale model to understand HIV-1 dynamics following host factor-induced perturbations. We found that reducing the influence of Vpu triggers a drop in Ro, revealing the impact of BST2 on viral infection control. Reducing Vif׳s effect reveals the restrictive efficacy of A3G in blocking RT and in inducing lethal hypermutations, however, neither of these factors alone is sufficient to fully restrict HIV-1 infection. Interestingly, our model further predicts that BST2 and A3G function synergistically, and delineates their relative contribution in limiting HIV-1 infection and disease progression. We provide a robust modeling framework for devising novel combination therapies that target

  19. ANALYSIS OF EXISTING DEFECTS OF THE RUSSIAN BUSINESS EDUCATION AND OPPORTUNITIES OF TRANSITION TO A NEW MODEL TRAINING

    Directory of Open Access Journals (Sweden)

    Larin S. N.

    2016-04-01

    Full Text Available Studying the problems of the development of Russian business education today seems urgent in view of the serious impact of globalization factors on world markets, as well as taking into account the factors of global economic recession and to the undeclared war sanctions restrictions against the Russian economy and not having under itself no justification other than political. The article presents the results of the analysis of positive and negative factors in the development of the Russian business education, because of which it was concluded, that for the further development of the Russian system of business education needs a new approach. It should be based on the formation of the conceptual model, taking into account the current realities in the Russian economy. The authors set out to become the key provisions of the new approach, namely to ensure the growth of professional and specialist competencies required functionality; the study of «effective practical techniques», a reasonable reduction of the duration of the MBA program of study; distribution of specialists trained in powers depending on their positions. The above provisions allowed forming a conceptual model of business education, which is based on four practical degree professional training laid. In addition, the article justified criteria for evaluating the quality and composition requirements for modern business education program. The proposed in the article new approach and the conceptual model of the development of Russian business education are targeted at practitioners who want to gain more knowledge in a limited period and very reasonable cost of education. The further development of the Russian business education system in the very near future will show the validity of this approach

  20. Opportunities for pharmaceutical care with critical pathways.

    Science.gov (United States)

    Koch, K E

    1995-01-01

    Critical pathways are multidisciplinary tools designed to improve patient care and efficiency. Almost every path requires some type of pharmacotherapeutic intervention, from selection of surgical prophylaxis to management of anticoagulation. Pharmacists should become involved with the critical pathway process because it offers an excellent opportunity to incorporate pharmaceutical care and to meet Joint Commission on Accreditation of Healthcare Organization compliance criteria.

  1. Concurrent sourcing and external supplier opportunism

    DEFF Research Database (Denmark)

    Mols, Niels Peter

    When a firm simultaneously makes and buys the same components then the firm uses concurrent sourcing. This paper presents an agency model for explaining how and when concurrent sourcing reduces the likelihood of external supplier opportunism. In the proposed model, the external supplier’s expected...... costs of opportunism are determined as a product of four factors. The four factors are: likelihood of discovering supplier opportunism, buyer’s internalized quantity as reaction to supplier opportunism, asset specificity of external supplier’s investments, and multiplicator effects. Each...

  2. Turnkey offering a claimed sector 'first'.

    Science.gov (United States)

    Law, Oliver

    2011-01-01

    Manufacturer and supplier of LED theatre lights, HD camera systems, video integration technologies, and ceiling support units, Trumpf Medical Systems UK, and "logistical services" company Canute International Medical Services (CIMS), one of whose specialities is providing mobile medical units for diagnostic imaging, have entered into a partnership that will see the two companies offer fully fitted out modular operating theatres and other medical/clinical buildings incorporating the latest technology and equipment, on a fully project-managed, "turnkey" basis. Oliver Law, Trumpf Medical Systems UK managing director, explains the background, and the new service's anticipated customer benefits.

  3. Shipping Firm to Offer Funeral Service

    Institute of Scientific and Technical Information of China (English)

    黄菊妹

    2001-01-01

    Japan’s largest shipping company, Nippon Yusen KK, plans to offer a new funeral ash-scattering service in a bid to (释义见19页文) capitalize on demand fuelled by the high ccst of cemeteries in Japan, a financial daily said Sunday. 日本最大的海运公司Nippon Yusen KK打算提供新的骨灰海葬服务,以求赢利。日本的公墓的价格居高不下,刺激了骨灰海葬的需求。一份金融日报星期日称。

  4. A Fuzzy ANP Model Integrated with Benefits, Opportunities, Costs, and Risks to Prioritize Intelligent Power Grid Systems

    Directory of Open Access Journals (Sweden)

    Hsing Hung Chen

    2013-01-01

    Full Text Available Although growth of renewable energy is envisaged, many concerns are critical like the ability to maintain the balance between demands and supply and the variability, noncontrollability, and flexibility of the sources. Then, what will be the future concerns about the main composition of intelligent power grid systems in the future? There is no such research tackled before. Thus, this paper first finds critical success criteria of intelligent power grid systems and then constructs a multiple criteria and decision making model to help in identifying the suitable trends under complex economic performance, environmental impacts, and rapid technological and marketing changes. After empirical demonstration, the paper summarizes that the most suitable composition of future intelligent power grid systems should be constituted by “DHT” P2P grid, “C&D workflow” P2P scheduling, “GARCM” trustworthy P2P grid, and “multipurpose” grid applications in the future.

  5. Suborbital Research and Development Opportunities

    Science.gov (United States)

    Davis, Jeffrey R.

    2011-01-01

    This slide presentation reviews the new strategies for problem solving in the life sciences in the suborbital realm. Topics covered are: an overview of the space life sciences, the strategic initiatives that the Space Life Sciences organization engaged in, and the new business model that these initiatives were developed. Several opportunities for research are also reviewed.

  6. Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans

    Directory of Open Access Journals (Sweden)

    Franck A. Atienzar

    2016-01-01

    Full Text Available Drug-induced liver injury (DILI is a major cause of late-stage clinical drug attrition, market withdrawal, black-box warnings, and acute liver failure. Consequently, it has been an area of focus for toxicologists and clinicians for several decades. In spite of considerable efforts, limited improvements in DILI prediction have been made and efforts to improve existing preclinical models or develop new test systems remain a high priority. While prediction of intrinsic DILI has improved, identifying compounds with a risk for idiosyncratic DILI (iDILI remains extremely challenging because of the lack of a clear mechanistic understanding and the multifactorial pathogenesis of idiosyncratic drug reactions. Well-defined clinical diagnostic criteria and risk factors are also missing. This paper summarizes key data interpretation challenges, practical considerations, model limitations, and the need for an integrated risk assessment. As demonstrated through selected initiatives to address other types of toxicities, opportunities exist however for improvement, especially through better concerted efforts at harmonization of current, emerging and novel in vitro systems or through the establishment of strategies for implementation of preclinical DILI models across the pharmaceutical industry. Perspectives on the incorporation of newer technologies and the value of precompetitive consortia to identify useful practices are also discussed.

  7. Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans

    Science.gov (United States)

    Blomme, Eric A.; Hewitt, Philip; Kenna, J. Gerry; Labbe, Gilles; Moulin, Frederic; Pognan, Francois; Roth, Adrian B.; Suter-Dick, Laura; Ukairo, Okechukwu; Weaver, Richard J.; Will, Yvonne; Dambach, Donna M.

    2016-01-01

    Drug-induced liver injury (DILI) is a major cause of late-stage clinical drug attrition, market withdrawal, black-box warnings, and acute liver failure. Consequently, it has been an area of focus for toxicologists and clinicians for several decades. In spite of considerable efforts, limited improvements in DILI prediction have been made and efforts to improve existing preclinical models or develop new test systems remain a high priority. While prediction of intrinsic DILI has improved, identifying compounds with a risk for idiosyncratic DILI (iDILI) remains extremely challenging because of the lack of a clear mechanistic understanding and the multifactorial pathogenesis of idiosyncratic drug reactions. Well-defined clinical diagnostic criteria and risk factors are also missing. This paper summarizes key data interpretation challenges, practical considerations, model limitations, and the need for an integrated risk assessment. As demonstrated through selected initiatives to address other types of toxicities, opportunities exist however for improvement, especially through better concerted efforts at harmonization of current, emerging and novel in vitro systems or through the establishment of strategies for implementation of preclinical DILI models across the pharmaceutical industry. Perspectives on the incorporation of newer technologies and the value of precompetitive consortia to identify useful practices are also discussed. PMID:27689095

  8. CURRICULAR OFFER INFLUENCING STUDENTS’ SATISFACTION: COMPARATIVE STUDY

    Directory of Open Access Journals (Sweden)

    Oana DUMITRASCU

    2014-11-01

    Full Text Available The main objective of the study is the determination of students’ satisfaction regarding curricular activities. The study has been accomplished using the qualitative and quantitative research, using the bibliographic study, various secondary sources and different primary sources. The study is developed with a marketing research and accomplished using the survey method. 699 students from four universities have been questioned. Due to a comparative study the University of Applied Sciences Worms, University of Applied Sciences Wiesbaden Rüsselsheim, University of Applied Sciences Frankfurt am Main and Nürtingen-Geislingen University have been analysed and their similarities and differences have been identified. The collected data, based on the established sample, is evaluated through univariate and bivariate analysis. In accordance with the evaluated sample, specific gaps from each region are identified regarding the curricular offer of the analysed universities. As a result to the conducted study, recommendations for the University of Applied Sciences Worms regarding the student’s satisfaction concerning the curricular offer are presented.

  9. Wind offering in energy and reserve markets

    Science.gov (United States)

    Soares, T.; Pinson, P.; Morais, H.

    2016-09-01

    The increasing penetration of wind generation in power systems to fulfil the ambitious European targets will make wind power producers to play an even more important role in the future power system. Wind power producers are being incentivized to participate in reserve markets to increase their revenue, since currently wind turbine/farm technologies allow them to provide ancillary services. Thus, wind power producers are to develop offering strategies for participation in both energy and reserve markets, accounting for market rules, while ensuring optimal revenue. We consider a proportional offering strategy to optimally decide upon participation in both markets by maximizing expected revenue from day-ahead decisions while accounting for estimated regulation costs for failing to provide the services. An evaluation of considering the same proportional splitting of energy and reserve in both day- ahead and balancing market is performed. A set of numerical examples illustrate the behavior of such strategy. An important conclusion is that the optimal split of the available wind power between energy and reserve strongly depends upon prices and penalties on both market trading floors.

  10. Offer - La Comédie theatre

    CERN Multimedia

    Staff Association

    2017-01-01

    The “La Comédie” theatre unveiled its programme for the season 2017–2018. We are delighted to share this brand new, rich and varied programme with you. The “La Comédie” theatre has various discounts for our members Buy 2 subscriptions for the price of 1 : 2 cards “Libertà” for CHF 240.- instead of CHF 480.- Cruise freely through the season with an 8-entry card valid for the shows of your choice. These cards are transferable and can be shared with one or more accompanying persons. 2 cards “Piccolo” for CHF 120 instead of CHF 240.- This card lets you discover 4 shows which are suitable for all audiences (offers valid while stock lasts) Benefit from a reduction of 20 % on a full price ticket during all the season: from CHF 40.- to CHF 24.- ticket instead of CHF 50.- to CHF 30.- depending on the show (Also valid for one accompanying person). Interested in one of these offers? Create an ac...

  11. Presentation tourism offer on the Internet

    Directory of Open Access Journals (Sweden)

    Ćurčić Nevena

    2006-01-01

    Full Text Available The Internet has become basic infrastructure for many jobs, a medium of representing many businesses and progressively influential source of information. Therefore, the Internet has developed into a significant distributing, communicational and trade channel in tourism and catering industry throughout the world and in this area as well. This paper is a short survey of various possibilities of the Internet, with the special emphasis on the analysis of Serbian tourism presence on the Internet, by means of tourism and catering offer in cyber companies’ system of services. The aim of the paper is to make partial systematization of the present tourist offer of Serbia on the Internet with the brief rating and analysis of the websites. The goal of the paper is to point out the presence of Serbian tourist and catering services on the Internet, the restricting factors in e-business of the country and the importance of further promotional activities of tourism of Serbia on the global network.

  12. CURRICULAR OFFER INFLUENCING STUDENTS’ SATISFACTION: COMPARATIVE STUDY

    Directory of Open Access Journals (Sweden)

    Oana DUMITRASCU

    2014-11-01

    Full Text Available The main objective of the study is the determination of students’ satisfaction regarding curricular activities. The study has been accomplished using the qualitative and quantitative research, using the bibliographic study, various secondary sources and different primary sources. The study is developed with a marketing research and accomplished using the survey method. 699 students from four universities have been questioned. Due to a comparative study the University of Applied Sciences Worms, University of Applied Sciences Wiesbaden Rüsselsheim, University of Applied Sciences Frankfurt am Main and Nürtingen-Geislingen University have been analysed and their similarities and differences have been identified. The collected data, based on the established sample, is evaluated through univariate and bivariate analysis. In accordance with the evaluated sample, specific gaps from each region are identified regarding the curricular offer of the analysed universities. As a result to the conducted study, recommendations for the University of Applied Sciences Worms regarding the student’s satisfaction concerning the curricular offer are presented.

  13. “CYTOKINE” MODEL OF PATHOGENESIS OF CHRONIC HEART FAILURE AND THE OPPORTUNITIES OF NEW THERAPEUTIC STRATEGY IN DECOMPENSATED PATIENTS

    Directory of Open Access Journals (Sweden)

    U. A. Vasuk

    2006-01-01

    Full Text Available Neurohumoral model of pathogenesis of chronic heart failure (CHF made it possible to develop new therapeutic approaches in patients with CHF . However , it became obvious that the ways of activation of neurohumoral systems in CHF are much more complicated. The increase in local synthesis of hormones causes the activation of inflammatory cytokines and protooncogenes, which have various negative effects. This allowed formulating immunoinflammatory conception of CHF pathogenesis, according to which the increase in interleukine-6 blood level is the marker of unfavorable prognosis for CHF , and the level of tumor necrosis factor-α (TNF-α straightly correlates with severity of clinical condition and neurohumoral activity in CHF . The growth of TNF-α in CHF progressing as well as its reduction in successful treatment do not exclude the probability of positive effect of therapy , focused on the reduction of TNF-α concentration. The pathogenesis peculiarities of CHF including cytokine aggression demand the necessity of development of new therapy approaches with the use of cytokine system modulators.

  14. An Offer You Cannot Refuse: Obtaining Efficiency and Fairness in Preplay Negotiation Games with Conditional Offers

    DEFF Research Database (Denmark)

    Goranko, Valentin; Turrini, Paolo

    2013-01-01

    . Such offers transform the payoff matrix of the original game and allow for some degree of cooperation between rational players while preserving the non-cooperative nature of the game. We focus on 2-player negotiations games arising in the preplay phase when offers for payments are made conditional...... on a suggested matching offer of the same kind being made in return by the receiver. We study and analyze such bargaining games, obtain results describing their possible solutions and discuss the degrees of efficiency and fairness that can be achieved in such negotiation process depending on whether time...

  15. Opportunities for offshore mineral exploration in the Indian Ocean

    Digital Repository Service at National Institute of Oceanography (India)

    Desa, E.

    The Indian Ocean offers several opportunities for offshore mineral resources in the nearshore and coastal areas, the EEZs of different countries as well as the deep sea regions. The coastal and nearshore resources of heavy mineral placers are being...

  16. A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation

    Directory of Open Access Journals (Sweden)

    Jaime Chu

    2013-01-01

    Individuals with congenital disorders of glycosylation (CDG have recessive mutations in genes required for protein N-glycosylation, resulting in multi-systemic disease. Despite the well-characterized biochemical consequences in these individuals, the underlying cellular defects that contribute to CDG are not well understood. Synthesis of the lipid-linked oligosaccharide (LLO, which serves as the sugar donor for the N-glycosylation of secretory proteins, requires conversion of fructose-6-phosphate to mannose-6-phosphate via the phosphomannose isomerase (MPI enzyme. Individuals who are deficient in MPI present with bleeding, diarrhea, edema, gastrointestinal bleeding and liver fibrosis. MPI-CDG patients can be treated with oral mannose supplements, which is converted to mannose-6-phosphate through a minor complementary metabolic pathway, restoring protein glycosylation and ameliorating most symptoms, although liver disease continues to progress. Because Mpi deletion in mice causes early embryonic lethality and thus is difficult to study, we used zebrafish to establish a model of MPI-CDG. We used a morpholino to block mpi mRNA translation and established a concentration that consistently yielded 13% residual Mpi enzyme activity at 4 days post-fertilization (dpf, which is within the range of MPI activity detected in fibroblasts from MPI-CDG patients. Fluorophore-assisted carbohydrate electrophoresis detected decreased LLO and N-glycans in mpi morphants. These deficiencies resulted in 50% embryonic lethality by 4 dpf. Multi-systemic abnormalities, including small eyes, dysmorphic jaws, pericardial edema, a small liver and curled tails, occurred in 82% of the surviving larvae. Importantly, these phenotypes could be rescued with mannose supplementation. Thus, parallel processes in fish and humans contribute to the phenotypes caused by Mpi depletion. Interestingly, mannose was only effective if provided prior to 24 hpf. These data provide insight into treatment efficacy

  17. Social problems as sources of opportunity – antecedents of social entrepreneurship opportunities

    Directory of Open Access Journals (Sweden)

    Agnieszka Żur

    2016-02-01

    Full Text Available Objective: Based on extensive literature review, this paper aims to establish if, why and how, in given environmental and market contexts, social entrepreneurship (SE opportunities are discovered and exploited. It positions social problems as sources of entrepreneurial opportunity. The article presents an integrated process-based view of SE opportunity antecedents and concludes with a dynamic model of SE opportunity. Research Design & Methods: To fulfil its goal, the paper establishes opportunity as unit of research and explores the dynamics of opportunity recognition. To identify the components of SE opportunity through a process-based view, the study follows the steps of critical literature review method. The literature review follows with logical reasoning and inference, which results in the formulation of a model proposition of social entrepreneurship opportunity. Findings: The paper presents a holistic perspective on opportunity antecedents in SE context and introduces social problems, information, social awareness and entrepreneurial mindset  as fundamental components of social entrepreneurship opportunity equation. Implications & Recommendations: It is necessary to remember for policy makers, investors and partners involved within the social sector, that social problems can be the source of entrepreneurial opportunity. Training, assisting and engaging socially aware entrepreneurs is a promising line of development for all communities. Contribution & Value Added: The major contribution of this study lies in extending the existing body of social entrepreneurship research by providing a new perspective, placing social problem as opportunity in the centre of the discussion.

  18. Virtual Reality System Offers a Wide Perspective

    Science.gov (United States)

    2008-01-01

    Robot Systems Technology Branch engineers at Johnson Space Center created the remotely controlled Robonaut for use as an additional "set of hands" in extravehicular activities (EVAs) and to allow exploration of environments that would be too dangerous or difficult for humans. One of the problems Robonaut developers encountered was that the robot s interface offered an extremely limited field of vision. Johnson robotics engineer, Darby Magruder, explained that the 40-degree field-of-view (FOV) in initial robotic prototypes provided very narrow tunnel vision, which posed difficulties for Robonaut operators trying to see the robot s surroundings. Because of the narrow FOV, NASA decided to reach out to the private sector for assistance. In addition to a wider FOV, NASA also desired higher resolution in a head-mounted display (HMD) with the added ability to capture and display video.

  19. Modelling height to diameter ratio – an opportunity to increase Norway spruce stand stability in the Western Carpathians

    Directory of Open Access Journals (Sweden)

    Bošeľa Michal

    2014-06-01

    Full Text Available Smrek je jednou z najrozšírenejších a ekonomicky najdôležitejších ihličnatých drevín v Európe. Taktiež je drevinou veľmi často poškodzovanou vetrovými kalamitami. Štíhlostný kvocient (pomer výšky a hrúbky stromu sa považuje za vhodný indikátor statickej stability jednotlivých stromov a porastov. Preto cieľom práce bola identifikácia hlavných faktorov, ktoré majú významný vplyv na hodnoty kvocientu. Jednoduchý model bol vytvorený ako pomôcka pre lesníka pri rozhodovaní o intenzite prebierok v smrekových porastoch s cieľom potenciálneho zvýšenia statickej stability a zachovania optimálnej produkcie. Využili sa údaje Národnej inventarizácie a monitoringu lesov SR (260 plôch a taktiež údaje z predchádzajúcich výskumných projektov (48 plôch tak aby reprezentovali čo najširšie rozpätie ekologických podmienok, v ktorých smrek v súčasnosti rastie. Výsledky ukázali, že najvýznamnejšími ekologickými faktormi boli: nadmorská výška a bonita stanovišťa. Taktiež niektoré porastové charakteristiky sa významne podieľali na variabilite kvocientu: podiel koruny z výšky stromu, hustota porastu a stredná porastová výška reprezentujúca rastovú fázu porastu. Výsledky ďalej preukázali, že ekologické podmienky sú významnejšie ako porastové charakteristiky, a preto tieto treba brať do úvahy pri rozhodovacom procese. To znamená, že ak sa porast nachádza na pre smrek veľmi bonitnom stanovišti, sú potrebné silnejšie prebierky od mladých rastových fáz, aby sa ovplyvňovaním hrúbkového prírastku vyrovnal vplyv rýchleho výškového rastu. Zároveň je dôležitá rozdielna intenzita výškového a hrúbkového rastu počas vývoja porastu

  20. Using Verification Code with Opportunity Model Based on CAPTCHA%基于CAPTCHA技术的挑战信息使用时机模型

    Institute of Scientific and Technical Information of China (English)

    朴顺姬; 戴德伟

    2012-01-01

    Rational use of verification code for the purpose of inhibiting the spread of the virus worm,the use of mathematical modeling methods to build a verification code uses opportunity mathematic model based CAPTCHA.Improvement strategy is proposed to make up an increase of the burden of customers and the network load for CAPTCHA.Thereby it is a qualitative analysis of the best time to use verification code.%为了合理使用挑战信息并达到抑制蠕虫病毒传播的目的,采用数学建模方法建立一个基于CAPTCHA技术的挑战信息使用时机数学模型.针对CAPTCHA技术增加了用户负担和网络负载的不足,提出了改进策略,要找到一个合适的时间发送挑战信息,从而定性的分析了使用挑战信息的最佳时机.

  1. Social media: opportunities for quality improvement and lessons for providers-a networked model for patient-centered care through digital engagement.

    Science.gov (United States)

    Bornkessel, Alexandra; Furberg, Robert; Lefebvre, R Craig

    2014-07-01

    Social media brings a new dimension to health care for patients, providers, and their support networks. Increasing evidence demonstrates that patients who are more actively involved in their healthcare experience have better health outcomes and incur lower costs. In the field of cardiology, social media are proposed as innovative tools for the education and update of clinicians, physicians, nurses, and medical students. This article reviews the use of social media by healthcare providers and patients and proposes a model of "networked care" that integrates the use of digital social networks and platforms by both patients and providers and offers recommendations for providers to optimize their use and understanding of social media for quality improvement.

  2. Genetic backgrounds and modifier genes of NTD mouse models: An opportunity for greater understanding of the multifactorial etiology of neural tube defects.

    Science.gov (United States)

    Leduc, Renee Y M; Singh, Parmveer; McDermid, Heather E

    2016-10-21

    Neurulation, the early embryonic process of forming the presumptive brain and spinal cord, is highly complex and involves hundreds of genes in multiple genetic pathways. Mice have long served as a genetic model for studying human neurulation, and the resulting neural tube defects (NTDs) that arise when neurulation is disrupted. Because mice appear to show mostly single gene inheritance for NTDs and humans show multifactorial inheritance, mice sometimes have been characterized as a simpler model for the identification and study of NTD genes. But are they a simple model? When viewed on different genetic backgrounds, many genes show significant variation in the penetrance and expressivity of NTD phenotypes, suggesting the presence of modifier loci that interact with the target gene to affect the phenotypic expression. Looking at mutations on different genetic backgrounds provides us with an opportunity to explore these complex genetic interactions, which are likely to better emulate similar processes in human neurulation. Here, we review NTD genes known to show strain-specific phenotypic variation. We focus particularly on the gene Cecr2, which is studied using both a hypomorphic and a presumptive null mutation on two different backgrounds: one susceptible (BALB/c) and one resistant (FVB/N) to NTDs. This strain difference has led to a search for genetic modifiers within a region on murine chromosome 19. Understanding how genetic variants alter the phenotypic outcome in NTD mouse models will help to direct future studies in humans, particularly now that more genome wide sequencing approaches are being used. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc.

  3. The private rejection of unfair offers and emotional commitment.

    Science.gov (United States)

    Yamagishi, Toshio; Horita, Yutaka; Takagishi, Haruto; Shinada, Mizuho; Tanida, Shigehito; Cook, Karen S

    2009-07-14

    In a series of experiments, we demonstrate that certain players of an economic game reject unfair offers even when this behavior increases rather than decreases inequity. A substantial proportion (30-40%, compared with 60-70% in the standard ultimatum game) of those who responded rejected unfair offers even when rejection reduced only their own earnings to 0, while not affecting the earnings of the person who proposed the unfair split (in an impunity game). Furthermore, even when the responders were not able to communicate their anger to the proposers by rejecting unfair offers in a private impunity game, a similar rate of rejection was observed. The rejection of unfair offers that increases inequity cannot be explained by the social preference for inequity aversion or reciprocity; however, it does provide support for the model of emotion as a commitment device. In this view, emotions such as anger or moral disgust lead people to disregard the immediate consequences of their behavior, committing them to behave consistently to preserve integrity and maintain a reputation over time as someone who is reliably committed to this behavior.

  4. Opportunities in Europe away from the US rat race

    CERN Multimedia

    Aldhous, P

    1993-01-01

    There are many opportunities for post-doctoral work in Europe for US scientists, and working in a well-known laboratory can be a good career move if ties to the US are maintained. Expatriate scientists offer advice on opportunities.

  5. Designing Opportunities to Learn Mathematics Theory-Building Practices

    Science.gov (United States)

    Bass, Hyman

    2017-01-01

    Mathematicians commonly distinguish two modes of work in the discipline: "Problem solving," and "theory building." Mathematics education offers many opportunities to learn problem solving. This paper explores the possibility, and value, of designing instructional activities that provide supported opportunities for students to…

  6. Self-contained cable systems offer advantages

    Energy Technology Data Exchange (ETDEWEB)

    Morello, A.S.; Occhini, E.

    1977-05-01

    Low-pressure oil-filled (LPOF) cable systems, while seldom used in this country, have several advantages of interest to engineers. Less oil and insulating paper is required for low-pressure than for the more commonly used high-pressure systems because of the single core. The lower pessure offers safety features in the event of accidental oil loss. LPOF cables are used internationally because of their good thermal characteristics. Applications besides ac transmission lines include underground and submarine cables, such as those connecting islands with mainland facilities. Cooling can be accomplished either by circulating oil inside the central duct or circulating water through parallel nonmetallic pipes. Forced-cooling of the LPOF cables is less complicated, which allows them to have higher current ratings and makes them more adaptable to thermal transients. Conductor cooling, which increases capacity but prohibits overloads in LPOF cables, is the only system available to high voltage (HVDC) cables. Several experimental and demonstration cable systems are described. (DCK)

  7. What Has Literature to Offer Computer Science?

    Directory of Open Access Journals (Sweden)

    Mark Dougherty

    2004-04-01

    Full Text Available In this paper I ask the question: what has literature to offer computer science? Can a bilateral programme of research be started with the aim of discovering the same kind of deep intertwining of ideas between computer science and literature, as already exists between computer science and linguistics? What practical use could such results yield? I begin by studying a classic forum for some of the most unintelligible pieces of prose ever written, the computer manual. Why are these books so hard to understand? Could a richer diet of metaphor and onomatopoeia help me get my laser printer working? I then dig down a little deeper and explore computer programs themselves as literature. Do they exhibit aesthetics, emotion and all the other multifarious aspects of true literature? If so, does this support their purpose and understandability? Finally I explore the link between computer code and the human writer. Rather than write large amounts of code directly, we encourage students to write algorithms as pseudo-code as a first step. Pseudo-code tells a story within a semi-formalised framework of conventions. Is this the intertwining we should be looking for?

  8. Industrial Heritage in Tuzla Canton Tourist Offer

    Directory of Open Access Journals (Sweden)

    Edin Jahić

    2014-04-01

    Full Text Available Industrial heritage has a great importance in development of tourism of Tuzla Canton because this is a region which had well developed industry in the past. Major part of this industry has been destroyed and now can be used for touristic purposes Besides this function, industrial plants can be used for development of culture, education, etc., and we already have such positive examples in wealthier European countries. The aim of the survey was to examine the opinion of tourist agencies, which are providers of tourist services, on further development of tourism in the region of Tuzla Canton, with special emphasis on industrial tourism, because tourist agencies are one of the key factors in creation of tourism development. Methods used for data collecting, processing and analysis are: historical, descriptive, comparative, case study, survey (SPSS version 20. Elements that need improving and further development are highlighted. The research results can help the tourist destination management, in this case TC, but also all segments of the tourism industry of TC, improve their offer and communication with a potential tourism market.

  9. Cycad mutualist offers more than pollen transport.

    Science.gov (United States)

    Marler, Thomas E

    2010-05-01

    Specialist insects share obligate mutualisms with some contemporary cycad species whereby the insect's pollination services are rewarded with a nursery in which the insect's larvae consume the postdispersal male cone. I prevented visits of the pollinator moth Anatrachyntis sp. to male Cycas micronesica (Cycadaceae) cones to show that consumption of the cone tissue by the mutualist hastened initiation of the plant's subsequent reproductive event. This is the first documented case where removal of a postdispersal cycad pollination organ speeds up subsequent reproductive events, and the current paradigm that the offering of cone tissue as a nursery is a sacrifice by the plant in return for the pollination services is therefore inaccurate. In C. micronesica, the herbivory stage of pollination mutualism confers a cryptic benefit of cone tissue disposal, which translates into an increase in ultimate lifetime reproductive effort. The plant population relies on the pollinator for moving gametes, as well as for increasing the number of male coning events. The dual benefits afforded to the plant by associating with this pollinator shows that mutualism can operate simultaneously on very different traits.

  10. PROBLEMA ANOMALI DALAM INITIAL PUBLIC OFFERING (IPO

    Directory of Open Access Journals (Sweden)

    Sautma Ronni Basana

    2003-01-01

    Full Text Available This study on Initial Public Offerings (IPO showed that IPO stocks on average were underpriced, underperformed in the long run aftermarket and the Hot and Cold market cycle was present. These phenomenom can be explained by among others, the following: Asymetric Information, Winner's Curse, Traditional-Ibbotson, and Signalling Equilibrium Phenomenom. However, all of these can't give a satisfactory explanation because they were based on the price which existed on the secondary market (Underpriced Theory. The Withdrawn IPO (WIPO theory tried to explain the IPO anomaly differently so that the IPO anomaly could be explained clearly. Abstract in Bahasa Indonesia : Studi tentang Penawaran Saham Perdana (IPO menunjukkan saham-saham IPO secara rata-rata mengalami Underpriced, kinerja jangka panjang yang jelek dan adanya siklus pasar "Hot" dan "Cold". Ada beberapa penjelasan terhadap fenomena tersebut, antara lain: Informasi Asimetri, WinnerCurse, Tradisional-Ibbotson, Signaling Equilibrium Phenomenom tetapi semuanya belum memuaskan karena berdasarkan pada basis harga yang ada di pasar sekunder (Teori Underpriced. Teori Withdrawn IPO (WIPO mencoba menjelaskan fenomena anomali IPO dengan cara yang berbeda sehingga fenomena anomali IPO dapat dijelaskan secara tuntas. Kata kunci: Penawaran Saham Perdana (IPO, Underpriced, Withdrawn IPO (WIPO.

  11. Altmetric opportunities for Libraries

    NARCIS (Netherlands)

    Gerritsma, W.

    2015-01-01

    Just over five years ago the concept of altmetrics was minted. For libraries and librarians this has brought a new plethora of opportunities. In the first place there is the traditional extension role. Outreach opportunities on the subject of altmetrics are manyfold, and librarians could seize the o

  12. Opportunities and challenges for textile reinforced composites

    Science.gov (United States)

    Pastore, Christopher M.

    2000-03-01

    For several decades researchers have been interested in textile processes for the production of composite reinforcement. These technologies have offered several promises: reduced fabrication costs, 3-D multiaxial reinforcement, and damage tolerance. Despite these advantages, textile composites have not reached the level of implementation of laminated composites. In this paper, the opportunities provided by textile reinforced composites and the challenges that limit their implementation will be discussed in detail. Textile composites refer to a family of processes: weaving, braiding, knitting, and hybrids thereof. The various families of textiles will be defined and the basics of fabric formation for each family will be detailed. In particular, the strengths and weaknesses of each manufacturing technique will be addressed to provide a view of the applicability of each technology. This will include some guidance on shape formation capability, property ranges, size limitations, and estimates of cost to produce. Potential applications for these materials will be presented. Among the limitations on the application of textile reinforced composites is the lack of adequate modeling capabilities for these materials. Textile composites have rather large unit cell structures and are highly inhomogeneous throughout their volumes. These features provide benefits in manufacturing, but require novel modeling techniques to correctly understand the mechanical behavior. A review of analytical techniques applied to textile composites will be presented along with a discussion of the benefits and weaknesses of each of these methods. The enabling technologies needed to further the implementation of textile composites in structural applications will be discussed.

  13. Equal opportunities in diversity

    CERN Multimedia

    Laëtitia Pedroso

    2010-01-01

    Promoting equal opportunities at CERN and advising the Director-General on all related matters is the task of the Equal Opportunities Officer, Doris Chromek-Burckhart, and Tim Smith, chair of the Equal Opportunities Advisory Panel. Changes are being introduced: in future, the focus of their work will be broadened to cover all aspects of diversity promotion.   The term "equal opportunities" has always been broader in scope than the equal treatment of men and women but this is what it has traditionally been confined to in practice. "We wanted to change how people see our mission", explains Doris Chromek-Burckhart. The word "diversity" has much wider connotations than "equal opportunities" and makes it clearer that we are also dealing with differences in nationality, religion, age, culture and physical ability”. Getting away from the old clichés is vital to ensuring equal treatment for everyone. The diversit...

  14. Inhibiting NAD+-dependent DNA ligase activity with 2-(cyclopentyloxy)-5'-deoxyadenosine (CPOdA) offers a new tool for DNA replication and repair studies in the model archaeon Haloferax volcanii.

    Science.gov (United States)

    Giroux, Xavier; MacNeill, Stuart A

    2015-11-01

    DNA ligases play an essential role in many aspects of DNA metabolism in all three domains of life. The haloarchaeal organism Haloferax volcanii encodes both ATP- and NAD(+)-dependent DNA ligase enzymes designated LigA and LigN, respectively. Neither LigA nor LigN alone is required for cell viability but they share an essential function, most likely the ligation of Okazaki fragments during chromosome replication. Here we show that 2-(cyclopentyloxy)-5'-deoxyadenosine (referred to as CPOdA), originally developed as a inhibitor of bacterial NAD(+)-dependent DNA ligases, is a potent inhibitor of the growth of Hfx. volcanii cells expressing LigN alone, causing chromosome fragmentation and cell death, while cells expressing LigA are unaffected. Growth inhibition occurs at significantly lower CPOdA concentrations (MIC ≤ 50 ng ml(-1)) than those required for inhibition of bacterial growth (≥2 μg ml(-1)). CPOdA has the potential to become a vital tool in DNA replication and repair studies in this important model organism.

  15. Your Vision or My Model? Lessons from Participatory Land Use Scenario Development on a European Scale

    DEFF Research Database (Denmark)

    Volkery, Axel; Ribeiro, Teresa; Henrichs, Thomas;

    2008-01-01

    Participatory processes in scenario development have received increasing attention throughout the last years. Combining qualitative stakeholder and quantitative expert information (i.e. modelling) offers unique opportunities to mix good data, scientific rigour, imagination and expertise from...

  16. Future Propulsion Opportunities for Commuter Airplanes

    Science.gov (United States)

    Strack, W. C.

    1982-01-01

    Commuter airplane propulsion opportunities are summarized. Consideration is given to advanced technology conventional turboprop engines, advanced propellers, and several unconventional alternatives: regenerative turboprops, rotaries, and diesels. Advanced versions of conventional turboprops (including propellers) offer 15-20 percent savings in fuel and 10-15 percent in DOC compared to the new crop of 1500-2000 SHP engines currently in development. Unconventional engines could boost the fuel savings to 30-40 percent. The conclusion is that several important opportunities exist and, therefore, powerplant technology need not plateau.

  17. Research opportunities to advance solar energy utilization.

    Science.gov (United States)

    Lewis, Nathan S

    2016-01-22

    Major developments, as well as remaining challenges and the associated research opportunities, are evaluated for three technologically distinct approaches to solar energy utilization: solar electricity, solar thermal, and solar fuels technologies. Much progress has been made, but research opportunities are still present for all approaches. Both evolutionary and revolutionary technology development, involving foundational research, applied research, learning by doing, demonstration projects, and deployment at scale will be needed to continue this technology-innovation ecosystem. Most of the approaches still offer the potential to provide much higher efficiencies, much lower costs, improved scalability, and new functionality, relative to the embodiments of solar energy-conversion systems that have been developed to date.

  18. Research Funding Opportunities for Early Career Scientists

    Science.gov (United States)

    Wiener, Richard

    2009-10-01

    This talk will describe opportunities for early career faculty members in the physical sciences to obtain funding for scientific research and educational projects. I will discuss programs offered by Research Corporation for Science Advancement, a private nonprofit foundation, which include opportunities for scientists at primarily undergraduate institutions and at research universities. I will emphasize strategies for successful grant writing. The target audience is early career academic scientists in Astronomy, Physics, and related fields, as well as graduate students and postdoctoral researchers considering careers in these academic disciplines.

  19. Online citizen science games: Opportunities for the biological sciences.

    Science.gov (United States)

    Curtis, Vickie

    2014-12-01

    Recent developments in digital technologies and the rise of the Internet have created new opportunities for citizen science. One of these has been the development of online citizen science games where complex research problems have been re-imagined as online multiplayer computer games. Some of the most successful examples of these can be found within the biological sciences, for example, Foldit, Phylo and EteRNA. These games offer scientists the opportunity to crowdsource research problems, and to engage with those outside the research community. Games also enable those without a background in science to make a valid contribution to research, and may also offer opportunities for informal science learning.

  20. Opportunity Identification and Creation as Factors of Firm Internationalisation

    Directory of Open Access Journals (Sweden)

    Agnieszka Żur

    2015-06-01

    and accuracy in opportunity identification. The article presents an integrated process-based view of opportunity antecedents and concludes with a dynamic cyclical path-dependent model of opportunity-based view of firm internationalisation. Hopefully, the proposed model can serve as a useful lens for hypotheses formulation and testing within the research on firm internationalisation determinants.

  1. Equal Opportunities Questionnaire

    CERN Document Server

    2007-01-01

    The initiative to promote Equal Opportunities at CERN started in 1993. The first Equal Opportunities Officer was appointed in 1996, which was followed by the creation of the Equal Opportunities Advisory Panel in 1998. Initially the concern was mainly the fair treatment of women in the work-place. Today the emphasis has evolved to ensuring that diversity is used to increase creativity and productivity in the work-place. In order to ensure that all aspects of Equal Opportunities and Diversity are covered, CERN’s Equal Opportunities team has prepared a survey to obtain your input. Your answers are confidential and will only be used for generating statistics. The questionnaire is on-line and can be accessed via: https://espace.cern.ch/EOQ. We hope that you will take a few minutes of your time to give your input and would be grateful if you could reply before 15/10/07. For further information about Equal Opportunities at CERN see: http://cern.ch/equal-opportunities The Equa...

  2. Equal Opportunities Questionnaire

    CERN Document Server

    2007-01-01

    The initiative to promote Equal Opportunities at CERN started in 1993. The first Equal Opportunities Officer was appointed in 1996 followed by the creation of the Equal Opportunities Advisory Panel in 1998. Initially the concern was mainly the fair treatment of women in the work-place. Today the emphasis has evolved to ensuring that diversity is used to increase creativity and productivity in the work-place. In order to ensure that all aspects of Equal Opportunities and Diversity are covered, CERN’s Equal Opportunities team has prepared a survey to obtain your input. Your answers are confidential and will only be used for generating statistics. The questionnaire is on-line and can be accessed via: https://espace.cern.ch/EOQ. We hope that you will take a few minutes of your time to give your input and would be grateful if you could reply before 15/10/07. For further information about Equal Opportunities at CERN see: http://cern.ch/equal-opportunities The Equal Opportuni...

  3. On inclusion of water resource management in Earth System models – Part 2: Representation of water supply and allocation and opportunities for improved modeling

    Directory of Open Access Journals (Sweden)

    A. Nazemi

    2014-07-01

    Full Text Available Human water use has significantly increased during the recent past. Water allocation from surface and groundwater sources has altered terrestrial discharge and storage, with large variability in time and space. Water supply and allocation, therefore, should be considered with water demand and appropriately included in large-scale models to address various online and offline implications, with or without considering possible climate interactions. Here, we review the algorithms developed to represent the elements of water supply and allocation in large-scale models, in particular Land Surface Schemes and Global Hydrologic Models. We noted that some potentially-important online implications, such as the effects of large reservoirs on land-atmospheric feedbacks, have not yet been addressed. Regarding offline implications, we find that there are important elements, such as groundwater availability and withdrawals, and the representation of large reservoirs, which should be improved. Major sources of uncertainty in offline simulations include data support, water allocation algorithms and host large-scale models. Considering these findings with those highlighted in our companion paper, we note that advancements in computation, host models, system identification algorithms as well as remote sensing and data assimilation products can facilitate improved representations of water resource management at larger scales. We further propose a modular development framework to consider and test multiple datasets, algorithms and host models in a unified model diagnosis and uncertainty assessment framework. We suggest that such a framework is required to systematically improve current representations of water resource management in Earth System models. A key to this development is the availability of regional scale data. We argue that the time is right for a global initiative, based on regional case studies, to move this agenda forward.

  4. The role of ability, motivation, and opportunity to work in the transition from work to early retirement - testing and optimizing the Early Retirement Model

    NARCIS (Netherlands)

    de Wind, Astrid; Geuskens, Goedele A; Ybema, Jan Fekke; Bongers, Paulien M; van der Beek, Allard J

    2015-01-01

    OBJECTIVES: Determinants in the domains health, job characteristics, skills, and social and financial factors may influence early retirement through three central explanatory variables, namely, the ability, motivation, and opportunity to work. Based on the literature, we created the Early Retirement

  5. The role of ability, motivation, and opportunity to work in the transition from work to early retirement : testing and optimizing the Early Retirement Model

    NARCIS (Netherlands)

    Wind, A. de; Geuskens, G.A.; Ybema, J.F.; Bongers, P.M.; Beek, A.J. van der

    2015-01-01

    Objectives Determinants in the domains health, job characteristics, skills, and social and financial factors may influence early retirement through three central explanatory variables, namely, the ability, motivation, and opportunity to work. Based on the literature, we created the Early Retirement

  6. The role of ability, motivation, and opportunity to work in the transition from work to early retirement : testing and optimizing the Early Retirement Model

    NARCIS (Netherlands)

    Wind, A. de; Geuskens, G.A.; Ybema, J.F.; Bongers, P.M.; Beek, A.J. van der

    2015-01-01

    Objectives Determinants in the domains health, job characteristics, skills, and social and financial factors may influence early retirement through three central explanatory variables, namely, the ability, motivation, and opportunity to work. Based on the literature, we created the Early Retirement

  7. The role of ability, motivation, and opportunity to work in the transition from work to early retirement - testing and optimizing the Early Retirement Model

    NARCIS (Netherlands)

    de Wind, Astrid; Geuskens, Goedele A; Ybema, Jan Fekke; Bongers, Paulien M; van der Beek, Allard J

    2015-01-01

    OBJECTIVES: Determinants in the domains health, job characteristics, skills, and social and financial factors may influence early retirement through three central explanatory variables, namely, the ability, motivation, and opportunity to work. Based on the literature, we created the Early Retirement

  8. Collaborative care in real-world settings: barriers and opportunities for sustainability.

    Science.gov (United States)

    Sanchez, Katherine

    2017-01-01

    Patient-centered care and self-management of chronic disease are optimally characterized by distinct adjunct services such as education, and support for the behavioral and psychosocial elements of managing disease. The collaborative care model for the treatment of depression and anxiety in primary care includes the integration of a behavioral health specialist, in collaboration with the primary care provider, and psychiatric consultation to effectively screen and treat common mental health problems. Dissemination and sustainability of the model have encountered numerous barriers across systems of care. This article represents a discussion of the key barriers to collaborative care and offers a discussion of opportunities for dissemination and sustainability of the model.

  9. Collaborative care in real-world settings: barriers and opportunities for sustainability

    Science.gov (United States)

    Sanchez, Katherine

    2017-01-01

    Patient-centered care and self-management of chronic disease are optimally characterized by distinct adjunct services such as education, and support for the behavioral and psychosocial elements of managing disease. The collaborative care model for the treatment of depression and anxiety in primary care includes the integration of a behavioral health specialist, in collaboration with the primary care provider, and psychiatric consultation to effectively screen and treat common mental health problems. Dissemination and sustainability of the model have encountered numerous barriers across systems of care. This article represents a discussion of the key barriers to collaborative care and offers a discussion of opportunities for dissemination and sustainability of the model.

  10. Towards electricity markets accommodating uncertain offers

    DEFF Research Database (Denmark)

    Papakonstantinou, Athanasios; Pinson, Pierre

    2014-01-01

    infrastructure investments. In this paper we propose a new electricity market mechanism whereby the uncertain and dynamic nature of wind power and other stochastic sources is embedded in the market mechanism itself, by modelling producers’ bids as probabilistic estimates. An extension on the bilevel programming...

  11. Simposium 19: Teaching Offers Many Possibilities

    Directory of Open Access Journals (Sweden)

    Denise Vaz Macedo

    2014-08-01

    Full Text Available K-Education(PortugueseChair: V. TrindadeBayardo Torres; Clovis Wannmacher; Denise Macedo  Teaching Offers Many Possibilities Denise Vaz Macedo Biochemistry Department, Biology Institute, Unicamp, Campinas, Brazil.   In the last years my research lines are maintained exclusively through my biochemistry teaching activities at graduation and specialization course (360h. The teaching methodology used was developed over these 20 years into the classroom research. It is based on five practical activities carried out at the initial moment by the students themselves, who monitor the effects of different physical activity situations through the measurement of some plasma metabolites on point of care devices. After instructions the students perform the exercises collects and tabulate the data generated and document all the doubts arising. The educational goal right now is to show that the theory related to muscle contraction, the ATP-producing metabolic pathways is linked to their profession. At adequate moments each group presents to the whole class the practical activity carried out, the data and the doubts produced. After a fully discussion the students are able to relate the data to the studied theory. Also the initial doubts are clarified. A questionnaire applied before and after the discipline indicates the learning effectiveness of this method. Some other results: the students who have demonstrated special interest in the classroom normally join into de lab. Simultaneously they are also prepared for the teaching activity. The demand of specialization course is greater than the supply. The financial resources generated are expressive and administered by the University Foundation. They are fully applied to purchase permanent and consumption materials and for the payment of eventual scholarships for lab researchers. The publication in indexed journals has been constant and regular, and the obtained experimental results always return to the

  12. Recruiting in an Opportunity Culture: Lessons Learned. An Opportunity Culture Vignette

    Science.gov (United States)

    Barrett, Sharon Kebschull

    2015-01-01

    When districts get ready to recruit excellent teachers for the career possibilities that Opportunity Culture roles offer, success may come down to two actions: Start early, and communicate constantly, say recruiters in Charlotte-Mecklenburg's Project L.I.F.T. (Leadership and Investment For Transformation) schools. What brings excellent teachers in…

  13. Environmental Modeling, The Natural Filter Buffer Targeting layers identify riparian forest and grass buffer opportunities by county. Land use and hydrology characteristics were used to identify potential riparian buffer locations., Published in 2014, Smaller than 1:100000 scale, Maryland Department of Natural Resources (DNR).

    Data.gov (United States)

    NSGIC Education | GIS Inventory — Environmental Modeling dataset current as of 2014. The Natural Filter Buffer Targeting layers identify riparian forest and grass buffer opportunities by county. Land...

  14. Angiogenesis and Its Therapeutic Opportunities

    Directory of Open Access Journals (Sweden)

    So Young Yoo

    2013-01-01

    Full Text Available Angiogenesis plays critical roles in human physiology that range from reproduction and fetal growth to wound healing and tissue repair. The sophisticated multistep process is tightly regulated in a spatial and temporal manner by “on-off switch signals” between angiogenic factors, extracellular matrix components, and endothelial cells. Uncontrolled angiogenesis may lead to several angiogenic disorders, including vascular insufficiency (myocardial or critical limb ischemia and vascular overgrowth (hemangiomas, vascularized tumors, and retinopathies. Thus, numerous therapeutic opportunities can be envisaged through the successful understanding and subsequent manipulation of angiogenesis. Here, we review the clinical implications of angiogenesis and discuss pro- and antiangiogenic agents that offer potential therapy for cancer and other angiogenic diseases.

  15. Expanding the Reach of Continuing Educational Offerings Through a Web-Based Virtual Network: The Experience of InspireNet.

    Science.gov (United States)

    Frisch, Noreen C; Atherton, Pat; Borycki, Elizabeth M; Mickelson, Grace; Black, Agnes; Novak Lauscher, Helen; Cordeiro, Jennifer

    2017-01-01

    Virtual platforms using webinars, e-posters, e-newsletters, wikis and blogs connect people who have common interests in new ways. When those individuals are healthcare providers, a professional network that operates on a virtual platform can support their needs for learning, professional development and information currency. The practice of e-learning for continuing professional development is emerging , particularly in nursing where shift work shift inhibits their ability to attend conferences and classes. This article reports the experience of the InspireNet network that provided e-learning models to: 1) provide opportunities for healthcare providers to organize themselves into learning communities through development of electronic communities of practice; 2) support learning on demand; and 3) dramatically increase the reach of educational offerings.

  16. Seizing Political Opportunity

    DEFF Research Database (Denmark)

    Citi, Manuele; Justesen, Mogens Kamp

    2016-01-01

    Political actors need to be nimble and respond to the opportunity to reform old policies and initiate new ones. The article looks at how the European Commission takes advantage of politically opportune moments (the ‘gridlock interval’) in the European Parliament to put forward new legislation....... As a ‘policy entrepreneur’, it is therefore able to navigate European institutions and bring about change....

  17. Challenges and opportunities in advancing models of care for older adults: an assessment of the National Institute on Aging research portfolio.

    Science.gov (United States)

    Liggins, Charlene; Pryor, Lisa; Bernard, Marie A

    2010-12-01

    To identify existing projects supported by the National Institute on Aging (NIA) that may relate to the recommendations for models of care (MOCs) presented in the 2008 Institute of Medicine Report, Retooling for an Aging America: Building the Healthcare Workforce. Cross-sectional analysis of NIA's grant portfolio. NIA. NIA grantees. NIA's grant portfolio was queried for the period 1999 to 2008 using a variety of search terms related to MOCs. Inclusion criteria were adherence to guiding principles for MOCs (comprehensive care, efficient care, older person as an active partner) or focus on innovative feature(s) of MOCs (interdisciplinary care, care management, chronic disease self-management, pharmaceutical management, preventive home visits, proactive rehabilitation, transitional care). Exclusion criteria were lack of focus on an intervention and focus on informal caregivers. Expert NIA staff reviewed and validated projects. One hundred thirty-five grants were identified. These grants represent fewer than 1% of the approximate number of grants NIA has funded over this same period of time (∼24,000 grants). Forty-four percent focused on components of comprehensive care and 34% on active involvement of older adults. Approximately half specifically focused on innovative features of MOCs, ranging from chronic disease self-management (32%) and proactive rehabilitation (26%) to preventive home visits (1%) and transitional care (1%). The majority of projects were investigator-initiated grants (46%). NIA has supported the development of many interventions that include components of MOCs related to recommendations from the IOM report. The challenge for the future will be determining which of the many components of comprehensive care systems are most effective for which subsets of the elderly population and assessing opportunities for enhanced collaboration between public and private aging research stakeholders. © 2010, Copyright the Authors. Journal compilation © 2010

  18. Valuating risk from sales contract offer maturity in electricity market

    Energy Technology Data Exchange (ETDEWEB)

    Bartelj, Ludvik; Gubina, Andrej F.; Golob, Robert [University of Ljubljana, Faculty of Electrical Engineering, Trzaska cesta 25, 1000 Ljubljana (Slovenia); Paravan, Dejan [GEN-I d.o.o., Cesta 4. Julija 42, 8270 KRSKO (Slovenia)

    2010-02-15

    The electricity retail business has always been exposed to a significant risk due to a very volatile nature of the wholesale electricity market. Recently, this trend has been accelerating, as electricity-forward price can rise or fall during one day by an amount comparable to the retailer's margin. As a result, the risk that arises from sales contract offer maturity can significantly reduce or even neutralize the retailer's profit. To develop a mitigation strategy for this risk, a retailer clearly needs a model for a detailed risk analysis. Many attempts have been made to analyze several risk issues of an electricity retail company, but so far none has explored and evaluated the sales contract offer maturity risk. This paper presents a fundamental model for evaluating this risk and a methodology for its use, and compares its analytical performance with traditional techniques obtained from the option-pricing theory. A realistic example illustrates the use and the benefits of the proposed model in risk analysis of the electricity retail business. (author)

  19. Immigrant Capital and Entrepreneurial Opportunities

    Directory of Open Access Journals (Sweden)

    Malavika Sundararajan

    2016-01-01

    Full Text Available Objective: The main objective of this study is to define and operationalize the concept of immigrant capital, a key factor that differentiates immigrant from host country entrepreneurs in how they recognize and start new ventures. Research Design & Methods: A detailed analysis of contemporary immigrant entrepreneurship and opportunity recognition literature was carried out. Using grounded theory, we synthesized the outcomes from the analysis of eight Canadian and U.S. case studies of successful immigrant entrepreneurs with the key findings from the literature to define and develop a model of immigrant capital. Findings: Based on our grounded theory development process we show that the concept of immigrant capital as a distillate of human, cultural, economic and social capital that goes beyond expected opportunity recognition (OR drivers like prior knowledge and prior experience to differentiate and enhance the immigrant entrepreneur’s ability to recognize business opportunities compared to host country entrepreneurs. We found immigrant capital to be a consequence of being boundary spanners in host and home country networks. Implications & Recommendations: Understanding a unique resource like immigrant capital, will help immigrant as well as host country entrepreneurs further develop their opportunity recognition ability by bridging gaps and fulfilling the needs for both, immigrant and host country consumers. Contribution & Value Added: The main contribution is the theoretical development, identification and definition of the immigrant capital model and propositions that will articulate the factors that lead to the conceptualization and operationalization of immigrant capital. Furthermore, the immigrant capital model can serve host country entrepreneurs to develop cross-cultural networks and jump-start entrepreneurial activities in their home countries as well as learn how to expand their operations into global markets.

  20. The Effect of Subsidies on the Offer of Sea Transport

    Directory of Open Access Journals (Sweden)

    Drago Pupavac

    2017-01-01

    Full Text Available The main goal of this academic discussion is to study the effect of subsidies on the offer of sea transport. Research results are based on the method of microeconomic analysis. The knowledge obtained through this academic discussion may prove to be of assistance to managers in the area of sea transport in deliberating on more efficient and market-oriented business models. The results of this work reveal that subsidies in sea transport make sense if they contribute to the improvement of the quality of transport or are of help to those for whom they are intended.

  1. Board of Commisioner Duality Role, Governance and Earnings Management of Initial Public Offerings in Indonesia

    Directory of Open Access Journals (Sweden)

    Widi Prasetiawati

    2011-09-01

    Full Text Available Public firm is required to implement good corporate governance as assurance to reduce information asymmetry between firm and its stockholders. Corporate governance mechanism should be able to limit any improper actions of the firm’s management. This study investigates whether the duality role of the board affects earnings management practice of firms making initial public offering at Indonesian Stock Exchange. The study also examines other corporate governance mechanism factors, namely the number of board of commission-ners, the proportion of independent board of commissioners, size of firm, financial leverage, and profitability. Earnings management was measured using Cross-Sectional Modified Jones model. The study employs a total of 60 firms that went public from 2000 to 2006. The results show that duality status of board of commissioners positively and significantly affects earnings management in IPO firms. This could be interpreted that board of directors with duality role had a lower function in monitoring the firms’ performance so that management have opportunity to manage reported earnings. When board of commissioners have dual role, the level of earnings management is getting intense, and vice versa. Size of board of commissioners and profitability are positively related to earnings management.

  2. Retail value: A more favorable offer?

    Directory of Open Access Journals (Sweden)

    Iván Alirio Ramírez Rusinque

    2014-06-01

    Full Text Available The most important transformation introduced by Law 1150 of 2007 in public procurement was the determination of goodwill as the absolute best deal for State entities, when concerned with the acquisition or provision of godos and services of uniform technical characteristics and common use. Therefore, an analysis from the point of legal and policy perspective is needed in order to establish whether the reform brought the concept of absolute best deal; or whether the solution was detrimental by affecting the duty of objective selection, the principles of equality, effectiveness, transparency, planning, and financial equilibrium of the contract and the constitutional principle of competition. Is the model of goodwill as a criterion for the absolute best deal legally effective in the field of public procurement?

  3. Cytogenomics of Feline Cancers: Advances and Opportunities

    OpenAIRE

    Rachael Thomas

    2015-01-01

    Relative to the dog, integration of the cat into the “One Health” concept has been more restricted, particularly in the field of molecular oncology. Beyond the continual need to enhance the sophistication of feline healthcare per se, the unique spectrum of naturally-occurring cancers in the cat offers tremendous opportunities for comparative and translational advances that may have mutual benefit for human and veterinary medicine. The study of feline cancers additionally may generate new insi...

  4. 7 CFR 1410.31 - Acceptability of offers.

    Science.gov (United States)

    2010-01-01

    ... Administrator for the for the area offered. Acceptance or rejection of any offer, however, shall be in the sole... 7 Agriculture 10 2010-01-01 2010-01-01 false Acceptability of offers. 1410.31 Section 1410.31... Acceptability of offers. (a) Except as provided in paragraph (c) of this section, producers may submit...

  5. 19 CFR 172.33 - Acceptance of offers in compromise.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Acceptance of offers in compromise. 172.33 Section... OF THE TREASURY (CONTINUED) CLAIMS FOR LIQUIDATED DAMAGES; PENALTIES SECURED BY BONDS Offers in Compromise § 172.33 Acceptance of offers in compromise. An offer in compromise will be considered...

  6. 19 CFR 171.32 - Acceptance of offers in compromise.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Acceptance of offers in compromise. 171.32 Section... OF THE TREASURY (CONTINUED) FINES, PENALTIES, AND FORFEITURES Offers in Compromise § 171.32 Acceptance of offers in compromise. An offer in compromise will be considered accepted only when the...

  7. Investment opportunities as real options

    Directory of Open Access Journals (Sweden)

    Adnan Rovčanin

    2005-06-01

    Full Text Available Opportunity (optional approach to capital investment appraisal represents, completely new theoretical and methodological framework for investment analysis. Compared to traditional, discount cash flow (DCF model of analysis, the optional approach provides opportunity for valuation and managing flexibility, i.e. possibility of approaching (amending the previous decisions in compliance with market changes. Risk and uncertainty are inevitably following the capital investment. Therefore, the importance of optional approach to investments is also that it provides possible better “treatment” of risks in the investment analysis, and also more rational allocation of resources, accordingly. This approach should be of more interest to the Countries in transition, considering the limited financial sources as well as risk and uncertainty are emphasized.

  8. Office of Equal Opportunity Programs

    Science.gov (United States)

    Chin, Jennifer L.

    2004-01-01

    The NASA Glenn Office of Equal Opportunity Programs works to provide quality service for all programs and/or to assist the Center in becoming a model workplace. During the summer of 2004, I worked with Deborah Cotleur along with other staff members to create and modify customer satisfaction surveys. This office aims to assist in developing a model workplace by providing functions as a change agent to the center by serving as an advisor to management to ensure equity throughout the Center. In addition, the office serves as a mediator for the Center in addressing issues and concerns. Lastly, the office provides assistance to employees to enable attainment of personal and organizational goals. The Office of Equal Opportunities is a staff office which reports and provides advice to the Center Director and Executive Leadership, implements laws, regulations, and presidential executive orders, and provides center wide leadership and assistance to NASA GRC employees. Some of the major responsibilities of the office include working with the discrimination complaints program, special emphasis programs (advisory groups), management support, monitoring and evaluation, contract compliance, and community outreach. During my internship in this office, my main objective was to create four customer satisfaction surveys based on EO retreats, EO observances, EO advisory boards, and EO mediation/counseling. I created these surveys after conducting research on past events and surveys as well as similar survey research created and conducted by other NASA centers, program for EO Advisory group members, leadership training sessions for supervisors, preventing sexual harassment training sessions, and observance events. I also conducted research on the style and format from feedback surveys from the Marshall Equal Opportunity website, the Goddard website, and the main NASA website. Using the material from the Office of Equal Opportunity Programs at Glenn Research Center along with my

  9. Office of Equal Opportunity Programs

    Science.gov (United States)

    Chin, Jennifer L.

    2004-01-01

    The NASA Glenn Office of Equal Opportunity Programs works to provide quality service for all programs and/or to assist the Center in becoming a model workplace. During the summer of 2004, I worked with Deborah Cotleur along with other staff members to create and modify customer satisfaction surveys. This office aims to assist in developing a model workplace by providing functions as a change agent to the center by serving as an advisor to management to ensure equity throughout the Center. In addition, the office serves as a mediator for the Center in addressing issues and concerns. Lastly, the office provides assistance to employees to enable attainment of personal and organizational goals. The Office of Equal Opportunities is a staff office which reports and provides advice to the Center Director and Executive Leadership, implements laws, regulations, and presidential executive orders, and provides center wide leadership and assistance to NASA GRC employees. Some of the major responsibilities of the office include working with the discrimination complaints program, special emphasis programs (advisory groups), management support, monitoring and evaluation, contract compliance, and community outreach. During my internship in this office, my main objective was to create four customer satisfaction surveys based on EO retreats, EO observances, EO advisory boards, and EO mediation/counseling. I created these surveys after conducting research on past events and surveys as well as similar survey research created and conducted by other NASA centers, program for EO Advisory group members, leadership training sessions for supervisors, preventing sexual harassment training sessions, and observance events. I also conducted research on the style and format from feedback surveys from the Marshall Equal Opportunity website, the Goddard website, and the main NASA website. Using the material from the Office of Equal Opportunity Programs at Glenn Research Center along with my

  10. Raiding Opportunities and Unemployment

    DEFF Research Database (Denmark)

    Tranæs, Torben

    2001-01-01

    This article studies the impact of raiding opportunities in a labor market in which worker abilities differ. Recruiting firms can either raid an elsewhere-employed worker of known ability by bidding up his wage or go through costly search to find a good worker among the unemployed. In equilibrium......, in particular, unemployment compensation, minimum wages, wage taxation, and search requirements.......This article studies the impact of raiding opportunities in a labor market in which worker abilities differ. Recruiting firms can either raid an elsewhere-employed worker of known ability by bidding up his wage or go through costly search to find a good worker among the unemployed. In equilibrium...

  11. PV opportunities in India

    Science.gov (United States)

    Stone, Jack L.; Ullal, Harin S.

    1996-01-01

    The growing middle class in India, coupled with a need for electricity to provide basic services to the masses, provides an opportunity to deploy photovoltaic systems in cost-effective applications ranging from grid-connected to isolated location requirements. This need is being satisfied by aggressive government programs, the availability of funds from agencies such as the World Bank, and the desire of Indian industries to form joint ventures for in-country manufacturing. The relaxed restrictions on doing business in India makes today's opportunities timely indeed.

  12. Modelling in Primary School: Constructing Conceptual Models and Making Sense of Fractions

    Science.gov (United States)

    Shahbari, Juhaina Awawdeh; Peled, Irit

    2017-01-01

    This article describes sixth-grade students' engagement in two model-eliciting activities offering students the opportunity to construct mathematical models. The findings show that students utilized their knowledge of fractions including conceptual and procedural knowledge in constructing mathematical models for the given situations. Some students…

  13. PREDICTION OF DEMAND FOR PRIMARY BOND OFFERINGS USING ARTIFICIAL NEURAL NETWORKS

    Directory of Open Access Journals (Sweden)

    Michal Tkac

    2014-12-01

    Full Text Available Purpose: Primary bond markets represent an interesting investment opportunity not only for banks, insurance companies, and other institutional investors, but also for individuals looking for capital gains. Since offered securities vary in terms of their rating, industrial classification, coupon, or maturity, demand of buyers for particular offerings often overcomes issued volume and price of given bond on secondary market consequently rises. Investors might be regarded as consumers purchasing required service according to their specific preferences at desired price. This paper aims at analysis of demand for bonds on primary market using artificial neural networks.Design/methodology: We design a multilayered feedforward neural network trained by Levenberg-Marquardt algorithm in order to estimate demand for individual bonds based on parameters of particular offerings. Outcomes obtained by artificial neural network are compared with conventional econometric methods.Findings: Our results indicate that artificial neural network significantly outperformed standard econometric techniques and on examined sample of primary bond offerings achieved considerably better performance in terms of prediction accuracy and mean squared error.Originality: We show that proposed neural network is able to successfully predict demand for primary obligation offerings based on their specifications. Moreover, we identify relevant parameters of issues which are able to considerably affect total demand for given security.  Our findings might not only help investors to detect marketable securities, but also enable issuing entities to increase demand for their bonds in order to decrease their offering price. 

  14. Opportunities for Biorenewables in Oil Refineries

    Energy Technology Data Exchange (ETDEWEB)

    Marker, T.L.

    2005-12-19

    Abstract: The purpose of this study was to evaluate the potential for using biorenewable feedstocks in oil refineries. Economic analyses were conducted, with support from process modeling and proof of principle experiments, to assess a variety of potential processes and configurations. The study considered two primary alternatives: the production of biodiesel and green diesel from vegetable oils and greases and opportunities for utilization of pyrolysis oil. The study identified a number of promising opportunities for biorenewables in existing or new refining operations.

  15. Metaphotonics: An emerging field with opportunities and challenges

    Science.gov (United States)

    Baev, Alexander; Prasad, Paras N.; Ågren, Hans; Samoć, Marek; Wegener, Martin

    2015-09-01

    Metaphotonics is an emerging multidisciplinary field that deals with manipulation of electro-magnetic fields in nanoengineered (meta)materials using both electric and magnetic interactions and their cross-coupling. It offers unprecedented control of both linear and nonlinear optical functions for applications ranging from optical switching, to negative- and near-zero refractive index metamaterials, to chiral bioimaging, to cloaking. However, realization of such applications requires physics-guided nanoengineering of appropriate artificial media with electro-magnetic properties at visible and infrared wavelengths that are tailored to surpass those of any naturally-occurring material. Here, we review metaphotonics with a broadened vision and scope, introduce potential applications, describe the role of theoretical physics through multiscale modeling, review the materials development and current status, and outline opportunities in this fertile emerging field.

  16. Opportunity parameters in the development of Product/Service-Systems

    DEFF Research Database (Denmark)

    Matzen, Detlef; Andreasen, Mogens Myrup

    2006-01-01

    In the light of the current focus on innovative business development throughout industry and society, the concept of product/service-systems (PSS) is a promising approach to product development, which may yield product offers that benefit the company, customer and society alike. Only recently...... researchers have made attempts to formulate requirements and procedures for the integration of product and service development [Steinbach 2005]. In the field of environmental studies, the concept of PSS has been investigated for some time, especially for the opportunities of lowering environmental impact...... models also use the terms functional products or total care products [Alonso-Rasgado et al. 2004]. In the age of industrial globalisation, we believe a PSS-based business integration can help traditional product based companies to strengthen their position in the marketplace. By following a product/service...

  17. Biofuels in Africa: growing small-scale opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Sulle, Emmanuel [Tanzania Natural Resources Forum (Tanzania, United Republic of); Fauveaud, Swan [Renewable Energy Group, Environment and Solidarity (France); Vermeulen, Sonja

    2009-11-15

    Global demand for climate-friendly transport fuels is driving vast commercial biofuels projects in developing countries. At the opposite end of the spectrum is small-scale bioenergy production. This offers a way for the poor to meet their energy needs and diversify their livelihoods without compromising food security or environmental integrity. Governments hope that it will be possible to combine the advantages of both large- and small-scale production of biofuels to generate energy security and GDP at the national level, while opening up local opportunities. In Africa, most governments are keen to attract foreign direct investment, and see big business as a strategic means of scaling up rural development. But there is a middle way. By encouraging business models that bridge large and small enterprise, African governments could show that commercial competition can go hand in hand with a range of real local benefits.

  18. Land of Expat Opportunity

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The international work force continues to grow as employment opportunities entice foreigners to live in China Forty-four-year-old Daniell Goodin has spent almost two decades working abroad, calling Indonesia, Hong Kong and the United States "home" for different periods of time. In May, the Australian native arrived in China, working

  19. Opportunity Cost: A Reply

    Science.gov (United States)

    Parkin, Michael

    2016-01-01

    The author's objective for this reply in reexamining opportunity cost was to draw attention to two conflicting definitions of the concept in current use and to argue the case for dropping one of them. The comments of Daniel Arce, Rod O'Donnell, and Daniel Stone might be read as demonstration that the author has failed on both counts. Such a…

  20. Expanding Student Assessment Opportunities.

    Science.gov (United States)

    Bartscher, Beth; Carter, Andrea; Lawlor, Anna; McKelvey, Barbara

    This paper describes an approach for expanding assessment opportunities for students to demonstrate their understanding of content. The targeted population consisted of elementary and junior high school students in two schools in a growing middle-class community in north central Illinois. The elementary school enrolled 467 students and the junior…

  1. Urbanization as opportunity

    OpenAIRE

    Fuller, Brandon; Romer, Paul

    2014-01-01

    Urbanization deserves urgent attention from policy makers, academics, entrepreneurs, and social reformers of all stripes. Nothing else will create as many opportunities for social and economic progress. The urbanization project began roughly 1,000 years after the transition from the Pleistocene to the milder and more stable Holocene interglacial. In 2010, the urban population in developing...

  2. Investment Insight Opportunities Ahead

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Over the next five years, China will be shitting its focus to more balanced development and what it sees as quality growth. Its two main strategies are promoting innovation-with the government-backed industrial upgrading-and strengthening the rural economy. This shift will lead to massive investment and fresh, wealth-making opportunities. In the stock

  3. The Educational Opportunity Bank.

    Science.gov (United States)

    Jellema, William W.

    The Educational Opportunity Bank (EOB) has received short shrift among educators and many objections have been raised to establishing it. Among these are the workability of the plan, the problem for women borrowers, and the creation of a new force--student financial power - in opposition to the influence of the Federal Government. Though…

  4. 48 CFR 619.804 - Evaluation, offering, and acceptance.

    Science.gov (United States)

    2010-10-01

    ....804 Evaluation, offering, and acceptance. ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Evaluation, offering, and acceptance. 619.804 Section 619.804 Federal Acquisition Regulations System DEPARTMENT OF STATE...

  5. 48 CFR 19.804 - Evaluation, offering, and acceptance.

    Science.gov (United States)

    2010-10-01

    ...) Program) 19.804 Evaluation, offering, and acceptance. ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Evaluation, offering, and acceptance. 19.804 Section 19.804 Federal Acquisition Regulations System FEDERAL ACQUISITION...

  6. FDA Offers Guidance on Fish Intake for Kids, Pregnant Women

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_163113.html FDA Offers Guidance on Fish Intake for Kids, Pregnant ... is far less than the recommended amount, the FDA said. Fish offers nutritional benefits important for growth ...

  7. 32 CFR 644.87 - Preparation and execution of offers.

    Science.gov (United States)

    2010-07-01

    ... the first and third lines, respectively, on page 2 of the offer form when title is being acquired free... applicable or can be fully complied with without the use of an Offer to Sell. Pages 1 and 2 of ENG Form 2970... Form 42, Offer to Sell Real Property, is required in all authorized projects, except in those cases...

  8. Final-Offer Arbitration: "Sudden Death" in Eugene

    Science.gov (United States)

    Long, Gary; Feuille, Peter

    1974-01-01

    A case study on final offer arbitration experiences in Eugene, Oregon, is presented and discussed. Basic criticisms leveled against the final-offer system are opposed by the authors and evidence is given in support of the use of final-offer arbitration. (DS)

  9. 7 CFR 1494.501 - Submission of offers to CCC.

    Science.gov (United States)

    2010-01-01

    ... before the time the offer is to be considered by CCC, unless otherwise required by law; (viii) No attempt... required certifications, unless CCC determines that acceptance of the offer would be in the best interests... 7 Agriculture 10 2010-01-01 2010-01-01 false Submission of offers to CCC. 1494.501 Section...

  10. 7 CFR 1494.601 - Acceptance of offers by CCC.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Acceptance of offers by CCC. 1494.601 Section 1494... Program Operations § 1494.601 Acceptance of offers by CCC. (a) Establishment of acceptable sales prices... that becomes available to CCC. (b) Acceptance of offers for a CCC bonus on a competitive basis....

  11. 26 CFR 601.203 - Offers in compromise.

    Science.gov (United States)

    2010-04-01

    ... penalty and the District Counsel concurs in the acceptance of the offer, or (iv) Recommend to the Regional Commissioner the acceptance of the offer if it involves a civil liability of $100,000 or over. (2)(i) If the... acceptance or rejection of the offer together with the examining officer's report of the investigation....

  12. 33 CFR 25.129 - Acceptance of offer of settlement.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Acceptance of offer of settlement. 25.129 Section 25.129 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL CLAIMS General § 25.129 Acceptance of offer of settlement. Claimant's acceptance of an offer...

  13. 26 CFR 300.3 - Offer to compromise fee.

    Science.gov (United States)

    2010-04-01

    ... taxpayer if the offer is accepted, rejected, withdrawn, or returned as nonprocessable after acceptance for... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Offer to compromise fee. 300.3 Section 300.3... ADMINISTRATION USER FEES § 300.3 Offer to compromise fee. (a) Applicability. This section applies to...

  14. 26 CFR 301.7430-7 - Qualified offers.

    Science.gov (United States)

    2010-04-01

    ... conference. (5) Remains open. A qualified offer must, by its terms, remain open for acceptance by the United... that would have resulted from the acceptance of E's qualified offer is a reduction in that liability of... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Qualified offers. 301.7430-7 Section...

  15. 31 CFR 50.13 - Offer, purchase, and renewal.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Offer, purchase, and renewal. 50.13... PROGRAM Disclosures as Conditions for Federal Payment § 50.13 Offer, purchase, and renewal. An insurer is deemed to be in compliance with the requirement of providing disclosure “at the time of offer,...

  16. Alternating-Offer Bargaining Games over the Gaussian Interference Channel

    CERN Document Server

    Liu, Xi

    2010-01-01

    This paper tackles the problem of how two selfish users jointly determine the operating point in the achievable rate region of a two-user Gaussian interference channel through bargaining. In previous work, incentive conditions for two users to cooperate using a simple version of Han-Kobayashi scheme was studied and the Nash bargaining solution (NBS) was used to obtain a fair operating point. Here a noncooperative bargaining game of alternating offers is adopted to model the bargaining process and rates resulting from the equilibrium outcome are analyzed. In particular, it is shown that the operating point resulting from the formulated bargaining game depends on the cost of delay in bargaining and how bargaining proceeds. If the associated bargaining problem is regular, a unique perfect equilibrium exists and lies on the individual rational efficient frontier of the achievable rate region. Besides, the equilibrium outcome approaches the NBS if the bargaining costs of both users are negligible.

  17. Investigating the International Awareness of Students Meeting Their International Dimension Requirement through Course Offerings in a College of Agriculture

    Science.gov (United States)

    Moriba, Samba; Edwards, M. Craig; Robinson, J. Shane; Cartmell, D. Dwayne, II; Henneberry, David M.

    2012-01-01

    Many U.S. universities are preparing their students to attain international awareness through various approaches. The College of Agricultural Sciences and Natural Resources (CASNR) at Oklahoma State University offers three international dimension undergraduate courses intended to provide students a formal educational opportunity to learn about…

  18. User Frustrations as Opportunities

    Directory of Open Access Journals (Sweden)

    Michael Weiss

    2012-04-01

    Full Text Available User frustrations are an excellent source of new product ideas. Starting with this observation, this article describes an approach that entrepreneurs can use to discover business opportunities. Opportunity discovery starts with a problem that the user has, but may not be able to articulate. User-centered design techniques can help elicit those latent needs. The entrepreneur should then try to understand how users are solving their problem today, before proposing a solution that draws on the unique skills and technical capabilities available to the entrepreneur. Finally, an in-depth understanding of the user allows the entrepreneur to hone in on the points of difference and resonance that are the foundation of a strong customer value proposition.

  19. Project X: Physics Opportunities

    CERN Document Server

    Kronfeld, Andreas S; Al-Binni, Usama; Altmannshofer, Wolfgang; Ankenbrandt, Charles; Babu, Kaladi; Banerjee, Sunanda; Bass, Matthew; Batell, Brian; Baxter, David V; Berezhiani, Zurab; Bergevin, Marc; Bernstein, Robert; Bhattacharya, Sudeb; Bishai, Mary; Blum, Thomas; Bogacz, S Alex; Brice, Stephen J; Brod, Joachim; Bross, Alan; Buchoff, Michael; Burgess, Thomas W; Carena, Marcela; Castellanos, Luis A; Chattopadhyay, Subhasis; Chen, Mu-Chun; Cherdack, Daniel; Christ, Norman H; Chupp, Tim; Cirigliano, Vincenzo; Coloma, Pilar; Coppola, Christopher E; Cowsik, Ramanath; Crabtree, J Allen; Delahaye, Jean-Pierre; Denisov, Dmitri; deNiverville, Patrick; de Gouvêa, André; Dharmapalan, Ranjan; Dolgov, Alexander; Dvali, Georgi; Eichten, Estia; Engelfried, Jürgen; Ferguson, Phillip D; Gabriel, Tony; Gal, Avraham; Gallmeier, Franz; Ganezer, Kenneth S; Gardner, Susan; Glenzinski, Douglas; Godfrey, Stephen; Golubeva, Elena S; Gori, Stefania; Graves, Van B; Greene, Geoffrey; Griffard, Cory L; Haisch, Ulrich; Handler, Thomas; Hartfiel, Brandon; Hawari, Ayman; Heilbronn, Lawrence; Hill, James E; Huber, Patrick; Jaffe, David E; Johnson, Christian; Kamyshkov, Yuri; Kaplan, Daniel M; Kerbikov, Boris; Kiburg, Brendan; Kirk, Harold G; Klein, Andreas; Knoepfel, Kyle; Kopeliovich, Boris; Kopeliovich, Vladimir; Kopp, Joachim; Korsch, Wolfgang; Kribs, Graham; Lipton, Ronald; Liu, Chen-Yu; Lorenzon, Wolfgang; Lu, Zheng-Tian; Makins, Naomi C R; McKeen, David; Mills, Geoffrey; Mohapatra, Rabindra; Mokhov, Nikolai V; Mocko, Michael; Muhrer, Guenter; Mumm, Pieter; Okun, Lev; Neuffer, David; Palmer, Mark A; Palmer, Robert; Pattie, Robert W; Phillips, David G; Pronsikh, Vitaly; Pitts, Kevin; Pospelov, Maxim; Quigg, Chris; Ramberg, Erik; Ray, Amlan; Reimer, Paul E; Richards, David G; Ritz, Adam; Roy, Amit; Ruggles, Arthur; Ryne, Robert; Sarkar, Utpal; Saunders, Andy; Semertzidis, Yannis K; Serebrov, Anatoly; Shimizu, Hirohiko; Shrock, Robert; Snopok, Pavel V; Snow, William M; Sikdar, Arindam K; Soha, Aria; Spanier, Stefan; Striganov, Sergei; Tang, Zhaowen; Townsend, Lawrence; Urheim, Jon; Vainshtein, Arkady; Van Kooten, Richard J; Van de Water, Richard; Van de Water, Ruth S; Wehring, Bernard; Whitehead, Lisa; Wilson, Robert J; Worcester, Elizabeth; Young, Albert R; Wester, William C; Zeller, Geralyn

    2013-01-01

    Part 2 of "Project X: Accelerator Reference Design, Physics Opportunities, Broader Impacts". In this Part, we outline the particle-physics program that can be achieved with Project X, a staged superconducting linac for intensity-frontier particle physics. Topics include neutrino physics, kaon physics, muon physics, electric dipole moments, neutron-antineutron oscillations, new light particles, hadron structure, hadron spectroscopy, and lattice-QCD calculations.

  20. Nanoethics: Challenges and Opportunities

    Science.gov (United States)

    Pompidou, Alain; Pompidou, Alain; Pompidou, Alain; Pompidou, Alain

    Nanoscience and its technological consequences constitute a relatively recent field of knowledge. Their rapid development around the world is characterised by an absence of specific norms and standards. Industrial applications, already promising, are not without risk, and this risk deserves to be fully and rigorously assessed. On the other hand, this vigilance and anticipation of risk does not need to deprive society as a whole of new opportunities, whether they be for developed countries and the emerging economies, or for less developed nations.

  1. Equal Opportunities Advisory Panel

    CERN Multimedia

    HR Department

    2006-01-01

    At its meeting on 7 December 2006, the Standing Concertation Committee took note of the appointment of four new members of the Panel: Wisla Carena, Pierre Charrue, Sue Foffano and Markus Nordberg. The present composition of the Panel (appointed ad personam) is as follows: Tiziano Camporesi (Chairperson), Wisla Carena, Pierre Charrue, Sue Foffano, Josi Schinzel (Equal Opportunities Officer), Markus Nordberg, Christine Petit-Jean-Genaz et Elena Wildner. Human Resources Department Tel. 74480

  2. Negotiating for more: the multiple equivalent simultaneous offer.

    Science.gov (United States)

    Heller, Richard E

    2014-02-01

    Whether a doctor, professional baseball manager, or a politician, having successful negotiation skills is a critical part of being a leader. Building upon prior journal articles on negotiation strategy, the author presents the concept of the multiple equivalent simultaneous offer (MESO). The concept of a MESO is straightforward: as opposed to making a single offer, make multiple offers with several variables. Each offer alters the different variables, such that the end result of each offer is equivalent from the perspective of the party making the offer. Research has found several advantages to the use of MESOs. For example, using MESOs, an offer was more likely to be accepted, and the counterparty was more likely to be satisfied with the negotiated deal. Additional benefits have been documented as well, underscoring why a prepared radiology business leader should understand the theory and practice of MESO. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  3. Resilience offers escape from trapped thinking on poverty alleviation.

    Science.gov (United States)

    Lade, Steven J; Haider, L Jamila; Engström, Gustav; Schlüter, Maja

    2017-05-01

    The poverty trap concept strongly influences current research and policy on poverty alleviation. Financial or technological inputs intended to "push" the rural poor out of a poverty trap have had many successes but have also failed unexpectedly with serious ecological and social consequences that can reinforce poverty. Resilience thinking can help to (i) understand how these failures emerge from the complex relationships between humans and the ecosystems on which they depend and (ii) navigate diverse poverty alleviation strategies, such as transformative change, that may instead be required. First, we review commonly observed or assumed social-ecological relationships in rural development contexts, focusing on economic, biophysical, and cultural aspects of poverty. Second, we develop a classification of poverty alleviation strategies using insights from resilience research on social-ecological change. Last, we use these advances to develop stylized, multidimensional poverty trap models. The models show that (i) interventions that ignore nature and culture can reinforce poverty (particularly in agrobiodiverse landscapes), (ii) transformative change can instead open new pathways for poverty alleviation, and (iii) asset inputs may be effective in other contexts (for example, where resource degradation and poverty are tightly interlinked). Our model-based approach and insights offer a systematic way to review the consequences of the causal mechanisms that characterize poverty traps in different agricultural contexts and identify appropriate strategies for rural development challenges.

  4. Resilience offers escape from trapped thinking on poverty alleviation

    Science.gov (United States)

    Lade, Steven J.; Haider, L. Jamila; Engström, Gustav; Schlüter, Maja

    2017-01-01

    The poverty trap concept strongly influences current research and policy on poverty alleviation. Financial or technological inputs intended to “push” the rural poor out of a poverty trap have had many successes but have also failed unexpectedly with serious ecological and social consequences that can reinforce poverty. Resilience thinking can help to (i) understand how these failures emerge from the complex relationships between humans and the ecosystems on which they depend and (ii) navigate diverse poverty alleviation strategies, such as transformative change, that may instead be required. First, we review commonly observed or assumed social-ecological relationships in rural development contexts, focusing on economic, biophysical, and cultural aspects of poverty. Second, we develop a classification of poverty alleviation strategies using insights from resilience research on social-ecological change. Last, we use these advances to develop stylized, multidimensional poverty trap models. The models show that (i) interventions that ignore nature and culture can reinforce poverty (particularly in agrobiodiverse landscapes), (ii) transformative change can instead open new pathways for poverty alleviation, and (iii) asset inputs may be effective in other contexts (for example, where resource degradation and poverty are tightly interlinked). Our model-based approach and insights offer a systematic way to review the consequences of the causal mechanisms that characterize poverty traps in different agricultural contexts and identify appropriate strategies for rural development challenges. PMID:28508077

  5. Concurrent sourcing and external supplier opportunism

    DEFF Research Database (Denmark)

    Mols, Niels Peter

    When a firm simultaneously makes and buys the same components then the firm uses concurrent sourcing. This paper presents an agency model for explaining how and when concurrent sourcing reduces the likelihood of external supplier opportunism. In the proposed model, the external supplier’s expected...

  6. Opportunities for pharmacy.

    Science.gov (United States)

    Schneider, Philip J

    2007-07-15

    To summarize key points from the most recent Institute of Medicine (IOM) report, Preventing Medication Errors, and their relevance to health-system pharmacists. Creating a culture of safety is an important antecedent to making changes needed to reduce medication errors. The patient can play an important, but often unrealized, role in preventing medication errors. There are considerable opportunities to improve the application of technology to prevent medication errors. The National Hospital Pharmacy surveys conducted ty the American Society of Health- System Pharmacists have demonstrated the slow rate of adoption of technologies. Pharmacists can play a leadership role in improving both the patients' role and the use of technology to improve medication-use safety. There are major opportunities for pharmacists to re-think how involved patients are in their care in the institutional setting, by seeing patients as building another check into the medication-use system and by recommitting ourselves to getting patients involved. There are also opportunities to help with patient-safety technology decisions. These extremely expensive technologies almost always involve people changing what they do and their implementation and use often involve other people besides pharmacists, yet the potential is great for new technologies to reduce medication errors.

  7. Addressing climate and energy misconceptions - teaching tools offered by the Climate Literacy and Energy Awareness Network (CLEAN)

    Science.gov (United States)

    Gold, A. U.; Ledley, T. S.; Kirk, K. B.; Grogan, M.; McCaffrey, M. S.; Buhr, S. M.; Manduca, C. A.; Fox, S.; Niepold, F.; Howell, C.; Lynds, S. E.

    2011-12-01

    Despite a prevalence of peer-reviewed scientific research and high-level reports by intergovernmental agencies (e.g., IPCC) that document changes in our climate and consequences for human societies, the public discourse regards these topics as controversial and sensitive. The chasm between scientific-based understanding of climate systems and public understanding can most easily be addressed via high quality, science-based education on these topics. Well-trained and confident educators are required to provide this education. However, climate science and energy awareness are complex topics that are rapidly evolving and have a great potential for controversy. Furthermore, the interdisciplinary nature of climate science further increases the difficulty for teachers to stay abreast of the science and the policy. Research has shown that students and educators alike hold misconceptions about the climate system in general and the causes and effects of climate change in particular. The NSF-funded CLEAN Pathway (http://cleanet.org) as part of the National Science Digital Library (http://www.nsdl.org) strives to address these needs and help educators address misconceptions by providing high quality learning resources and professional development opportunities to support educators of grade levels 6 through 16. The materials focus on teaching climate science and energy use. The scope and framework of the CLEAN Pathway is defined by the Essential Principles of Climate Science (CCSP, 2009) and the Energy Literacy Principles recently developed by the Department of Energy. Following this literacy-based approach, CLEAN helps with developing mental models to address misconceptions around climate science and energy awareness through a number of different avenues. These are: 1) Professional development opportunities for educators - interactive webinars for secondary teachers and virtual workshops for college faculty, 2) A collection of scientifically and pedagogically reviewed, high

  8. 76 FR 45546 - Public Meeting on Recommendations for Improvement of Student Financial Aid Offer Forms...

    Science.gov (United States)

    2011-07-29

    ... Model Financial Aid Forms AGENCY: Office of Postsecondary Education, Department of Education. ACTION... higher education (including financial aid administrators, registrars, and business officers), and... information regarding the financial aid offered. (6) Any other information the Secretary of...

  9. Semester abroad opportunities in baccalaureate nursing programs.

    Science.gov (United States)

    Read, Catherine Y

    2011-01-01

    An experience of studying abroad enhances undergraduate nursing education by broadening the student's perspective about different cultures, heightening awareness of a global society and foreign customs and traditions, stimulating interest in international work and research, fostering personal development, building skill in a foreign language, and serving as a bridge between theory and practice. Despite a large number of published reports about international experiences for nursing students, little is known about the number of baccalaureate programs that offer a semester abroad or the percent of students who participate. A mailed paper-and-pencil survey was completed by 382 administrators of baccalaureate nursing programs listed in the American Association of Colleges of Nursing database. Eighty-nine schools (23.3%) offer a semester study abroad opportunity. Of those, 39 (44%) offer clinical nursing courses taught by nursing faculty. Most (76%) of the 89 schools reported that only 0%-5% of students participated in the semester abroad program. Despite the small number of baccalaureate programs that offer a semester abroad experience and the small percentage of students who participate, respondents listed a large number and variety of advantages and offered strategies that facilitate their programs. Curricular innovations that allow 17%-26% of juniors in the baccalaureate nursing program at Boston College to study abroad for a semester are elucidated. Copyright © 2011 Elsevier Inc. All rights reserved.

  10. The Offering, Scheduling and Maintenance of Elective Advanced Pharmacy Practice Experiences

    Directory of Open Access Journals (Sweden)

    Rex O. Brown

    2015-12-01

    Full Text Available The Accreditation Council for Pharmacy Education (ACPE provides standards for colleges of pharmacy to assist in the provision of pharmacy education to student pharmacists. An integral part of all college educational programs includes the provision of experiential learning. Experiential learning allows students to gain real-world experience in direct patient care during completion of the curriculum. All college of pharmacy programs provide several Advanced Pharmacy Practice Experiences (APPEs, which include a balance between the four required experiences and a number of other required or elective APPEs. Required APPEs include advanced community, advanced institutional, ambulatory care, and general medicine. The elective APPEs include a myriad of opportunities to help provide a balanced education in experiential learning for student pharmacists. These unique opportunities help to expose student pharmacists to different career tracks that they may not have been able to experience otherwise. Not all colleges offer enough elective APPEs to enable the student pharmacist to obtain experiences in a defined area. Such an approach is required to produce skilled pharmacy graduates that are capable to enter practice in various settings. Elective APPEs are scheduled logically and are based upon student career interest and site availability. This article describes the offering, scheduling and maintenance of different elective APPEs offered by The University of Tennessee College of Pharmacy.

  11. Franchise Opportunities Handbook.

    Science.gov (United States)

    Office of Minority Business Enterprise (DOC), Washington, DC.

    Franchising continues to be one of the rapidly growing forms of business because it offers a means through which an individual with limited capital and experience can own or operate his own business. The publication, in its eighth edition, identifies franchisors who do not discriminate on the basis of race, color, or national origin in the…

  12. Investment Opportunities & Job Infomiation

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Teaching Vacancies International Business School, Yanjing Overseas Chinese University, located in Fengtai District, Beijing, is seeking five ESL teachers for this semester. Foreign teachers will mainly teach English writing, reading, listening and conversation. There are no more than 20 students aged 18 to 28 in a class. The school will offer 4,500-

  13. Environmental metabolomics: a SWOT analysis (strengths, weaknesses, opportunities, and threats).

    Science.gov (United States)

    Miller, Marion G

    2007-02-01

    Metabolomic approaches have the potential to make an exceptional contribution to understanding how chemicals and other environmental stressors can affect both human and environmental health. However, the application of metabolomics to environmental exposures, although getting underway, has not yet been extensively explored. This review will use a SWOT analysis model to discuss some of the strengths, weaknesses, opportunities, and threats that are apparent to an investigator venturing into this relatively new field. SWOT has been used extensively in business settings to uncover new outlooks and identify problems that would impede progress. The field of environmental metabolomics provides great opportunities for discovery, and this is recognized by a high level of interest in potential applications. However, understanding the biological consequence of environmental exposures can be confounded by inter- and intra-individual differences. Metabolomic profiles can yield a plethora of data, the interpretation of which is complex and still being evaluated and researched. The development of the field will depend on the availability of technologies for data handling and that permit ready access metabolomic databases. Understanding the relevance of metabolomic endpoints to organism health vs adaptation vs variation is an important step in understanding what constitutes a substantive environmental threat. Metabolomic applications in reproductive research are discussed. Overall, the development of a comprehensive mechanistic-based interpretation of metabolomic changes offers the possibility of providing information that will significantly contribute to the protection of human health and the environment.

  14. Nurse executives: new roles, new opportunities.

    Science.gov (United States)

    Kleinman, C S

    1999-01-01

    As women have been nursing since the earliest days of recorded civilization, so nurses have been associated with health care since the earliest days of recorded medical history. Gender and function have been inextricably woven in ways that created a struggle for success within a male-dominated industry. Nurses, as women, have been undervalued as, until recently, their role in health care has been similarly undervalued. Changing realities in the health care environment have created an opportunity for women's unique skills and talents to be revalued in a way that offers new opportunities for nurses. Teamwork, global thinking, multitasking, creativity, and flexibility are characteristics that have assumed new importance in the marketplace. Nursing leaders possess these attributes, along with a strong clinical foundation that is integrated with knowledge of sound business principles. This combination now positions nurse executives to reach the highest levels of heath care administration. Critical to this achievement is the professional credibility obtained through education at the master's degree level in health care and nursing administration programs that provide the essential tools for professional success. New opportunities for nurse executives afford educators in health care and nursing administration similar opportunities to develop and market programs to this large group of health care professionals who are seeking graduate education in increasing numbers.

  15. SuperB: An opportunity to study baryons with beauty and bottom super-nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Feliciello, A., E-mail: Alessandro.Feliciello@to.infn.it [Istituto Nazionale di Fisica Nucleare, Sezione di Torino, Via P. Giuria 1, I-10125 Torino (Italy)

    2012-05-01

    SuperB is an INFN flagship project for a new high-luminosity heavy-flavor factory. Along with its companion detector, it is dedicated to the search for CP violation effects in the B meson sector with the aim of looking for direct and indirect signals of new physics, beyond the Standard Model. However it could offer as well the opportunity for a systematic, high-statistics study of b baryon properties and for a search for bottom super-nuclei, that is bound nuclear systems with an explicit content of beauty.

  16. The advent of canine performance science: offering a sustainable future for working dogs.

    Science.gov (United States)

    Cobb, Mia; Branson, Nick; McGreevy, Paul; Lill, Alan; Bennett, Pauleen

    2015-01-01

    Working and sporting dogs provide an essential contribution to many industries worldwide. The common development, maintenance and disposal of working and sporting dogs can be considered in the same way as other animal production systems. The process of 'production' involves genetic selection, puppy rearing, recruitment and assessment, training, housing and handling, handler education, health and working life end-point management. At present, inefficiencies throughout the production process result in a high failure rate of dogs attaining operational status. This level of wastage would be condemned in other animal production industries for economic reasons and has significant implications for dog welfare, as well as public perceptions of dog-based industries. Standards of acceptable animal use are changing and some historically common uses of animals are no longer publicly acceptable, especially where harm is caused for purposes deemed trivial, or where alternatives exist. Public scrutiny of animal use appears likely to increase and extend to all roles of animals, including working and sporting dogs. Production system processes therefore need to be transparent, traceable and ethically acceptable for animal use to be sustainable into the future. Evidence-based approaches already inform best practice in fields as diverse as agriculture and human athletic performance. This article introduces the nascent discipline of canine performance science, which aims to facilitate optimal product quality and production efficiency, while also assuring evidence-based increments in dog welfare through a process of research and development. Our thesis is that the model of canine performance science offers an objective, transparent and traceable opportunity for industry development in line with community expectations and underpins a sustainable future for working dogs. This article is part of a Special Issue entitled: Canine Behavior.

  17. Regulatory environment and claims - limits and opportunities.

    Science.gov (United States)

    Martin, Ambroise

    2010-01-01

    During the past decade, the use of claims became more and more important in many countries in relation to the increased awareness of consumer about the link between foods and health, offering to industry a valuable opportunity to differentiate and valorize their products and to promote innovation. However, more and more stringent regulations are developed, all based on the general principles adopted by the Codex Alimentarius Commission. In addition to the different regulatory processes and administrative requirements according to the country, the high level (and cost) of scientific substantiation of claims, the constraints introduced by nutrient profiles and the poor knowledge of the impact on consumer depending on the cultural contexts may limit these opportunities or, at least complicate their use. All these issues are briefly analyzed, highlighting some striking convergences and differences between countries.

  18. Secondary school physics availability in an urban setting: Issues related to academic achievement and course offerings

    Science.gov (United States)

    Kelly, Angela M.; Sheppard, Keith

    2009-10-01

    High school physics is a gateway course for post-secondary study in science, and an essential component in the formation of students' scientific literacy. The opportunity to study physics is not universally available for children in U.S. schools, particularly in urban areas. Restricted science opportunities result in inequitable participation and a barrier to future participation in STEM-related fields. Although the national trend in physics enrollment has recently shown an increase, the percentage of participation is much lower for students in urban schools. We examined the availability of physics in New York City, and whether access was related to academic achievement measures, such as prior science performance, and graduation and college attendance percentages. High schools that offered physics were compared to those that did not, and patterns in types of available physics courses were examined. The findings substantiate the compelling need to explore the barriers to increased physics access and participation for urban youth.

  19. Ethical Perspectives of Equal Opportunities

    Directory of Open Access Journals (Sweden)

    Traian PALADE

    2016-07-01

    Full Text Available This paper focuses on the analysis of the fair equality of the concept of opportunity from the perspective of the moral and reasonable justifications brought to support positive discrimination. Although contemporary democratic societies guarantee the absence of discrimination by securing the formal equality of opportunity, this seems to be insufficient to balance opportunities. The Rawlsian model has gained ground, by advancing a redistribution of the resources to support the disadvantaged ones, which is implemented through special measures. The compulsory quotas for admission to higher education or public institutions, addressed to some disadvantaged groups, are one of the effective means of implementing fairness. As this system has shattered the principle of reward judging by one‟s merits, and ending up as a form of inverse discrimination of the majority groups, it is necessary that we analyse the arguments and the boomerang effects of the special measures. The undertaking proposed by the present paper is structured around highlighting the ethical aspects, as well as the consequences resulting from the arguments in favour of positive discrimination. Do we have the moral obligation to make up for the past inequalities suffered by some groups? Does preferential treatment really ensure the genuine integration of such groups? Do special measures contribute in creating social justice? Without the claim of having responded definitively and exhaustively to these questions, this paper attempts to emphasise the ethical dilemma that raises when special measures favour one group or another, when a group is protected judging by only one criterion, or when only an implementation area is selected.

  20. Opportunities and challenges of high-performance computing in chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Guest, M.F.; Kendall, R.A.; Nichols, J.A. [eds.] [and others

    1995-06-01

    The field of high-performance computing is developing at an extremely rapid pace. Massively parallel computers offering orders of magnitude increase in performance are under development by all the major computer vendors. Many sites now have production facilities that include massively parallel hardware. Molecular modeling methodologies (both quantum and classical) are also advancing at a brisk pace. The transition of molecular modeling software to a massively parallel computing environment offers many exciting opportunities, such as the accurate treatment of larger, more complex molecular systems in routine fashion, and a viable, cost-effective route to study physical, biological, and chemical `grand challenge` problems that are impractical on traditional vector supercomputers. This will have a broad effect on all areas of basic chemical science at academic research institutions and chemical, petroleum, and pharmaceutical industries in the United States, as well as chemical waste and environmental remediation processes. But, this transition also poses significant challenges: architectural issues (SIMD, MIMD, local memory, global memory, etc.) remain poorly understood and software development tools (compilers, debuggers, performance monitors, etc.) are not well developed. In addition, researchers that understand and wish to pursue the benefits offered by massively parallel computing are often hindered by lack of expertise, hardware, and/or information at their site. A conference and workshop organized to focus on these issues was held at the National Institute of Health, Bethesda, Maryland (February 1993). This report is the culmination of the organized workshop. The main conclusion: a drastic acceleration in the present rate of progress is required for the chemistry community to be positioned to exploit fully the emerging class of Teraflop computers, even allowing for the significant work to date by the community in developing software for parallel architectures.

  1. Funding Opportunity: Genomic Data Centers

    Science.gov (United States)

    Funding Opportunity CCG, Funding Opportunity Center for Cancer Genomics, CCG, Center for Cancer Genomics, CCG RFA, Center for cancer genomics rfa, genomic data analysis network, genomic data analysis network centers,

  2. Sport's offer as an instrument of sports marketing mix

    Directory of Open Access Journals (Sweden)

    Gašović Milan

    2004-01-01

    Full Text Available Taking logical postulate that a product is all what can be offered on the market in order to satisfy needs, demands or wants of customer, regarding the core of sport's offer (product, marketing experts must give answers to three key questions: What can sports companies, teams or individuals offer to consumer? What needs can sports companies, teams or individuals satisfy? What instruments (techniques and methods should use marketing experts in sports organizations in order to satisfy identified customer needs? .

  3. At Your Request((R)) room service dining improves patient satisfaction, maintains nutritional status, and offers opportunities to improve intake

    NARCIS (Netherlands)

    Doorduijn, A.S.; Gameren, Y. van; Vasse, E.; Roos, N.M. de

    2016-01-01

    BACKGROUND: Malnutrition in hospitals may be combatted by improving the meal service. AIM: To evaluate whether At Your Request((R)), a meal service concept by Sodexo with a restaurant style menu card and room service, improved patient satisfaction, nutritional status, and food intake compared to the

  4. Scope of sustainability - do castor beans and the biodiesel industry offer family farmers a sustainable development opportunity in Brazil?

    NARCIS (Netherlands)

    Florin, M.J.; Ven, van de G.W.J.; Ittersum, van M.K.

    2011-01-01

    Sustainable bio-energy is interwoven with sustainable rural development for family farmers. In this context, the Brazilian government is pursuing a “social inclusion” goal by means of family farmers providing a fraction of biodiesel feedstock. In 2009, the state-run petroleum company established a

  5. Effective Professional Development as Cultural Exchange: Opportunities Offered by Visits of Headteacher Groups from Malaysia to the UK

    Science.gov (United States)

    Burstow, Bob

    2009-01-01

    Arising from the visit by several cohorts of leading Malaysian secondary headteachers to the United Kingdom, this article examines the potential values and obstacles surrounding such international continuing professional development. The constraints of differences in language and context are considered, as well as issues of visiting heads as…

  6. Informal Opportunity among SMEs

    DEFF Research Database (Denmark)

    Rezaei, Shahamak; Dana, Leo-Paul; Goli, Marco

    2013-01-01

    Based on interviews with (legal and illegal) immigrants to Denmark, meetings with stakeholders and with experts in the field, this article addresses issues regarding the underground economy. Our findings show that, in Denmark, the existence of an underground economy makes it possible for semi......-compliant and non-compliant immigrants to make a living. We suggest that the underground economy in Denmark will continue to provide networks of illegal residents with opportunities for informal economic activities as trust allows entrepreneurs to function below the radar, by owning enterprises registered using...

  7. Frontier Aerospace Opportunities

    Science.gov (United States)

    Bushnell, Dennis M.

    2014-01-01

    Discussion and suggested applications of the many ongoing technology opportunities for aerospace products and missions, resulting in often revolutionary capabilities. The, at this point largely unexamined, plethora of possibilities going forward, a subset of which is discussed, could literally reinvent aerospace but requires triage of many possibilities. Such initial upfront homework would lengthen the Research and Development (R&D) time frame but could greatly enhance the affordability and performance of the evolved products and capabilities. Structural nanotubes and exotic energetics along with some unique systems approaches are particularly compelling.

  8. Creating Innovative Opportunities

    DEFF Research Database (Denmark)

    Ljungberg, Daniel; McKelvey, Maureen; Lassen, Astrid Heidemann

    2012-01-01

    to illustrations of the processes, and the 86 case studies in knowledge intensive entrepreneurship in Europe. These case studies were developed during the European Union research project AEGIS (Advancing Knowledge-Intensive Entrepreneurship and Innovation for Economic Growth and Well-being in Europe). The case...... studies do demonstrate how the individual KIE ventures are dependent upon variables and processes in the surrounding innovation systems. The overall analysis of the cases provides insight into how KIE processes link the KIE venture and the innovation system, thereby highlighting e.g. the importance...... of knowledge networks to create innovative opportunities....

  9. Entrepreneurship Training for Females Offers New Challenges to Career Educators.

    Science.gov (United States)

    Eliason, Carol

    1981-01-01

    Recent efforts in entrepreneurship training for women are described. These include research and development efforts, opportunities in the public schools, and the development of guidelines for career counseling to potential female entrepreneurs. (CT)

  10. Investment Opportunities & Job Information

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Teaching Vacancy: Xiamen University Tan Kan Kee College, approved by the Ministry of Education of China, was established jointly by Xiamen University and Xiamen Tan Kah Kee Educational Development Ltd. in 2003. As a comprehensive and independent college originated from Xiamen University, Tan Kah Kee College currently offers undergraduate programs. Xiamen University offers us enormous support. The college shares with Xiamen University not only their teaching facilities and faculty but also their well-known original style of pedagogy, which ensures the high quality of talent cultivation. Furthermore, to meet the international standards of higher education and the ever-growing needs of a market economy for qualified college graduates. Tan Kan Kee College dedicates itself to talent-cultiva-

  11. Investment Opportunities & Job Information

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Teaching Vacancies: Guangdong Huiyang Senior Middle School, located in Huizhou of Guangdong Province is seeking for three or four ESL English teachers for the September semester. Salary offered is 5,000 yuan per month for 20 teaching hours every week. Besides, the school will provide round airfare, traffic allowance, medical insurance, and free accommodation. Candidates should be native English speakers from the United States,

  12. Multiphysics simulations: challenges and opportunities.

    Energy Technology Data Exchange (ETDEWEB)

    Keyes, D.; McInnes, L. C.; Woodward, C.; Gropp, W.; Myra, E.; Pernice, M. (Mathematics and Computer Science); (KAUST and Columbia Univ.); (Lawrence Livermore National Laboratory); (Univ. of Illinois at Urbana-Champaign); (Univ. of Mich.); (Idaho National Lab.)

    2012-11-29

    This report is an outcome of the workshop Multiphysics Simulations: Challenges and Opportunities, sponsored by the Institute of Computing in Science (ICiS). Additional information about the workshop, including relevant reading and presentations on multiphysics issues in applications, algorithms, and software, is available via https://sites.google.com/site/icismultiphysics2011/. We consider multiphysics applications from algorithmic and architectural perspectives, where 'algorithmic' includes both mathematical analysis and computational complexity and 'architectural' includes both software and hardware environments. Many diverse multiphysics applications can be reduced, en route to their computational simulation, to a common algebraic coupling paradigm. Mathematical analysis of multiphysics coupling in this form is not always practical for realistic applications, but model problems representative of applications discussed herein can provide insight. A variety of software frameworks for multiphysics applications have been constructed and refined within disciplinary communities and executed on leading-edge computer systems. We examine several of these, expose some commonalities among them, and attempt to extrapolate best practices to future systems. From our study, we summarize challenges and forecast opportunities. We also initiate a modest suite of test problems encompassing features present in many applications.

  13. Cardiac to cancer: connecting connexins to clinical opportunity.

    Science.gov (United States)

    Grek, Christina L; Rhett, J Matthew; Ghatnekar, Gautam S

    2014-04-17

    Gap junctions and their connexin components are indispensable in mediating the cellular coordination required for tissue and organ homeostasis. The critical nature of their existence mandates a connection to disease while at the same time offering therapeutic potential. Therapeutic intervention may be offered through the pharmacological and molecular disruption of the pathways involved in connexin biosynthesis, gap junction assembly, stabilization, or degradation. Chemical inhibitors aimed at closing connexin channels, peptide mimetics corresponding to short connexin sequences, and gene therapy approaches have been incredibly useful molecular tools in deciphering the complexities associated with connexin biology. Recently, therapeutic potential in targeting connexins has evolved from basic research in cell-based models to clinical opportunity in the form of human trials. Clinical promise is particularly evident with regards to targeting connexin43 in the context of wound healing. The following review is aimed at highlighting novel advances where the pharmacological manipulation of connexin biology has proven beneficial in animals or humans. Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  14. Teaching Technical Writing: Opportunities for International Collaboration

    Directory of Open Access Journals (Sweden)

    Leslie E. Seawright

    2014-03-01

    Full Text Available Globalization of our modern economies requires a workforce that can move easily between time zones and cultures. Professors cannot ignore the drastic impact globalization has and will place upon engineering students. In order to be prepared for a competitive job market and the actual requirements of many engineering positions, students need to understand the constraints and challenges of working with colleagues that may live and work in different cultures, countries, languages, and contexts. However, engineering education rarely offers students an opportunity to practice the realities of our digital and intercultural working environments. This paper outlines one way to offer engineering students with collaborative, international, and intercultural writing projects. Students from a technical writing course in the United States were paired with engineering students in Qatar to develop a set of instructions using multimedia methods. Students learned a great deal from the real-world experience of writing and creating a project across two continents.

  15. New opportunities and responsibilities with PSS

    DEFF Research Database (Denmark)

    and compete on the global market. One innovation strategy that has attained increasing attention the past years is transforming business from being based on the sale of goods to business based on offering a combined prod-uct-service system that continuously provides value to the customer. This approach has...... and management of the development process? - What are the new dimensions in the service oriented perspective? PSS and the market: - How can we align the interests of PSS provider and customer? - What are the roles of stakeholders in the development of PSS? - How can companies make use of the many opportunities...... been dubbed “product/service-systems (PSS)”. The term is related and shared with other terms such as “functional economy”, “functional (total care) products”, “market offer development” and “service engineering”. PSS Research Over recent years a growing number of studies and research programmes have...

  16. Opportunity and obligation

    CERN Document Server

    2012-01-01

    As anyone in the press or VIP offices can tell you, CERN is in the spotlight like never before. In the first two months of 2012, we welcomed some 56 VIP visits and 144 media visits on site. Not long ago, those were the kind of numbers we’d have had in six months, and 2012 is not a one-off.   Ever since CERN turned 50 in 2004, our visitor numbers have been growing, and that includes teachers and members of the public as well as VIPs and the media. It’s a sign of the explosion of interest around the world in our science, and to me it means two things. Firstly, it means that I owe everyone at CERN a vote of thanks, since I know that visits impinge on everyone’s time. I can assure you all, however, that it is time well spent. That’s because the second thing it tells me is that growing interest in CERN brings opportunity. Our current visibility gives the particle physics community the opportunity to drive science up the popular and political agendas, and it...

  17. Triple Play Service and IPTV Services Offered within it

    Directory of Open Access Journals (Sweden)

    Dagmar Pajdusakova

    2008-01-01

    Full Text Available This paper deals with Triple Play multimedia service and figures its architecture. Triple Play offers voice, video and data services together in one customer connection. There is offered IPTV (Internet Protocol Television service within this service, where we can include also Video on Demand service and other different additional services. In the paper is described classification of Video on Demand services.

  18. 21 CFR 1270.42 - Human tissue offered for import.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Human tissue offered for import. 1270.42 Section...) REGULATIONS UNDER CERTAIN OTHER ACTS ADMINISTERED BY THE FOOD AND DRUG ADMINISTRATION HUMAN TISSUE INTENDED FOR TRANSPLANTATION Inspection of Tissue Establishments § 1270.42 Human tissue offered for import. (a...

  19. 45 CFR 2544.115 - Who may offer a donation?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Who may offer a donation? 2544.115 Section 2544... COMMUNITY SERVICE SOLICITATION AND ACCEPTANCE OF DONATIONS § 2544.115 Who may offer a donation? Anyone... donation to the Corporation....

  20. 48 CFR 219.804 - Evaluation, offering, and acceptance.

    Science.gov (United States)

    2010-10-01

    ... Business Administration (The 8(a) Program) 219.804 Evaluation, offering, and acceptance. When processing... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Evaluation, offering, and acceptance. 219.804 Section 219.804 Federal Acquisition Regulations System DEFENSE ACQUISITION...

  1. 14 CFR 151.29 - Procedures: Offer, amendment, and acceptance.

    Science.gov (United States)

    2010-01-01

    ... § 151.29 Procedures: Offer, amendment, and acceptance. (a) Upon approving a project, the Administrator... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Procedures: Offer, amendment, and acceptance. 151.29 Section 151.29 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT...

  2. 48 CFR 52.247-51 - Evaluation of Export Offers.

    Science.gov (United States)

    2010-10-01

    ... Government bill of lading. (1) Offers shall be evaluated and awards made on the basis of the lowest laid down...) Unless offers are applicable only to f.o.b. origin delivery under Government bills of lading (see... authorities of the St. Lawrence Seaway (normal period is between April 15 and November 30 annually). All...

  3. 47 CFR 76.1621 - Equipment compatibility offer.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Equipment compatibility offer. 76.1621 Section... MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Notices § 76.1621 Equipment compatibility offer. Cable system... individual compatibility problems. (d) Cable operators shall provide such equipment at the request...

  4. Service offerings and agreements a guide for ITIL exam candidates

    CERN Document Server

    Griffiths, Richard

    2014-01-01

    By implementing good practice in service offerings and agreements, IT departments can achieve customer satisfaction. Providing clarification and expansion of the core ITIL® texts, this new edition reflects the current thinking from ITIL and is aligned to the latest syllabus for the Intermediate Certificate in Service Offerings and Agreements.

  5. Nonprofit Groups Offer Genetic Testing for Jewish Students

    Science.gov (United States)

    Supiano, Beckie

    2008-01-01

    This article describes how nonprofit organizations like Hillel are offering free genetic testing for Jewish college students. A growing number of colleges, including Pittsburgh, Brandeis University, and Columbia University are offering students free or reduced-cost screenings for diseases common to Jewish population. Genetic diseases common to…

  6. 12 CFR 16.4 - Communications not deemed an offer.

    Science.gov (United States)

    2010-01-01

    ... Section 16.4 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY SECURITIES OFFERING...) Subsequent to the filing of a registration statement, any notice, circular, advertisement, letter, or other... CFR 230.134); (3) Subsequent to the filing of a registration statement, any oral offer of...

  7. 31 CFR 316.1 - Offering of bonds.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Offering of bonds. 316.1 Section 316.1 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT OFFERING OF UNITED STATES SAVINGS BONDS, SERIES E §...

  8. Service offerings and agreements a guide for ITIL exam candidates

    CERN Document Server

    Griffiths, Richard

    2014-01-01

    By implementing good practice in service offerings and agreements, IT departments can achieve customer satisfaction. Providing clarification and expansion of the core ITIL® texts, this new edition reflects the current thinking from ITIL and is aligned to the latest syllabus for the Intermediate Certificate in Service Offerings and Agreements.

  9. Information Uncertainty in Electricity Markets: Introducing Probabilistic Offers

    DEFF Research Database (Denmark)

    Papakonstantinou, Athanasios; Pinson, Pierre

    2016-01-01

    We propose a shift from the current paradigm of electricity markets treating stochastic producers similarly to conventional ones in terms of their offers. We argue that the producers’ offers should be probabilistic to reflect the limited predictability of renewable energy generation, while we...

  10. Negotiation as a form of persuasion: arguments in first offers.

    Science.gov (United States)

    Maaravi, Yossi; Ganzach, Yoav; Pazy, Asya

    2011-08-01

    In this article we examined aspects of negotiation within a persuasion framework. Specifically, we investigated how the provision of arguments that justified the first offer in a negotiation affected the behavior of the parties, namely, how it influenced counteroffers and settlement prices. In a series of 4 experiments and 2 pilot studies, we demonstrated that when the generation of counterarguments was easy, negotiators who did not add arguments to their first offers achieved superior results compared with negotiators who used arguments to justify their first offer. We hypothesized and provided evidence that adding arguments to a first offer was likely to cause the responding party to search for counterarguments, and this, in turn, led him or her to present counteroffers that were further away from the first offer.

  11. Shakespeare and the Common Core: An Opportunity to Reboot

    Science.gov (United States)

    Turchi, Laura; Thompson, Ayanna

    2013-01-01

    The Common Core generally eschews mandating texts in favor of promoting critical analysis and rigor. So it's significant that Shakespeare is the only author invoked in imperatives. His explicit inclusion offers a significant opportunity for educators to rethink how we approach Shakespearean instruction. Rather than the traditional learning of…

  12. Participatory catchment management: an opportunity for South Africa

    CSIR Research Space (South Africa)

    Versfeld, DB

    1995-01-01

    Full Text Available offer a new opportunity for communities living within these catchments to share their knowledge and to become involved in planning and implementing the management process. This paper discusses the use of Participatory Rural Appraisal (PRA) in a catchment...

  13. Mapping Pedagogical Opportunities Provided by Mathematics Analysis Software

    Science.gov (United States)

    Pierce, Robyn; Stacey, Kaye

    2010-01-01

    This paper proposes a taxonomy of the pedagogical opportunities that are offered by mathematics analysis software such as computer algebra systems, graphics calculators, dynamic geometry or statistical packages. Mathematics analysis software is software for purposes such as calculating, drawing graphs and making accurate diagrams. However, its…

  14. MOOCs as a Massive Research Laboratory: Opportunities and Challenges

    Science.gov (United States)

    Diver, Paul; Martinez, Ignacio

    2015-01-01

    Massive open online courses (MOOCs) offer many opportunities for research into several topics related to pedagogical methods and student incentives. In the context of over 20 years of online learning research, we discuss lessons to be learned from observational comparisons and experiments on randomly chosen groups of students. We target two MOOCs…

  15. The non-profit sector and the market: opportunities & challenges.

    Science.gov (United States)

    2001-11-01

    By carefully examining the most important challenges and opportunities facing America's private non-profit organizations, the Non-profit Sector Strategy Group is working to stimulate a new consensus about the non-profit sector's roles and responsibilities, and offer practical recommendations to enhance policy, practice, research, and public education on this crucial set of institutions.

  16. The Global Workforce: Opportunities and the Value Chain.

    Science.gov (United States)

    Martin, Tessie Sue; Flinn, Leslie

    2003-01-01

    Discusses the issues surrounding the value changes that impact opportunities for workforce development. Emerging technologies have changed the way labor is deployed. Offers exercises aimed at helping community colleges to understand the strengths and weaknesses of the industries they serve. Contains three figures and five references. (NB)

  17. Systems constellations : A better way to identify branding opportunities?

    NARCIS (Netherlands)

    Jurg, W.; Bloemer, J.; Doorewaard, H.; Peelen, E.

    2008-01-01

    Building strong brands has become one of the main marketing priorities for brand-supportive companies. The leading positivist paradigm in marketing may not be, however, the most-effective perspective in identifying branding opportunities. This paper offers an alternative phenomenological point of vi

  18. Opportunities and challenges for seaweed in the biobased economy

    NARCIS (Netherlands)

    Hal, van J.W.; Huijgen, W.J.J.; Lopez Contreras, A.M.

    2014-01-01

    The unique chemical composition of seaweeds and their fast growth rates offer many opportunities for biorefining. In this article we argue that cascading biorefinery valorization concepts are viable alternatives to only using seaweeds as carbohydrate sources for the fermentative production of biofue

  19. Increasing Students' Opportunities to Respond: A Strategy for Supporting Engagement

    Science.gov (United States)

    Menzies, Holly M.; Lane, Kathleen Lynne; Oakes, Wendy Peia; Ennis, Robin Parks

    2017-01-01

    This article offers a rationale for using a low-intensity support, increasing opportunities to respond, to promote students' academic engagement and decrease disruptive behaviors. A step-by-step guide to implementing this strategy in the classroom setting is presented.

  20. Participatory Pedagogy in an Open Educational Course: Challenges and Opportunities

    Science.gov (United States)

    Andersen, Renate; Ponti, Marisa

    2014-01-01

    This article presents an empirical study of an open educational course in an online peer-to-peer university (P2PU). P2PU is a nonprofit organization offering free educational opportunities. Focus is on how peers are part of creating course content in a Web 2.0 environment. Massive open online courses (MOOCs) have evolved into two different…