Sperm competition games: A general model for precopulatory male-male competition
Parker, G.A.; Lessells, C.M.; Simmons, L.W.
2013-01-01
Reproductive males face a trade-off between expenditure on precopulatory male–male competition—increasing the number of females that they secure as mates—and sperm competition—increasing their fertilization success with those females. Previous sperm allocation models have focused on scramble competi
General Information about Male Breast Cancer
... the body, such as cirrhosis ( liver disease) or Klinefelter syndrome (a genetic disorder .) Having several female relatives ... and procedures may be used: Physical exam and history : An exam of the body to check general ...
Generalized Poisson sigma models
Batalin, I; Batalin, Igor; Marnelius, Robert
2001-01-01
A general master action in terms of superfields is given which generates generalized Poisson sigma models by means of a natural ghost number prescription. The simplest representation is the sigma model considered by Cattaneo and Felder. For Dirac brackets considerably more general models are generated.
Generalized simplicial chiral models
Alimohammadi, M
2000-01-01
Using the auxiliary field representation of the simplicial chiral models on a (d-1)-dimensional simplex, we generalize the simplicial chiral models by replacing the term Tr$(AA^{\\d})$ in the Lagrangian of these models, by an arbitrary class function of $AA^{\\d}; V(AA^{\\d})$. This is the same method that has been used in defining the generalized two-dimensional Yang-Mills theories (gYM_2) from ordinary YM_2. We call these models, the " generalized simplicial chiral models ". With the help of the results of one-link integral over a U(N) matrix, we compute the large-N saddle-point equations for eigenvalue density function $\\ro (z)$ in the weak ($\\b >\\b_c$) and strong ($\\b <\\b_c$) regions. In d=2, where the model somehow relates to gYM_2 theory, we solve the saddle-point equations and find $\\ro (z)$ in two region, and calculate the explicit value of critical point $\\b_c$ for $V(B)=TrB^n (B=AA^{\\d})$. For $V(B)=Tr B^2,Tr B^3$ and Tr$B^4$, we study the critical behaviour of the model at d=2, and by calculating t...
General Composite Higgs Models
Marzocca, David; Shu, Jing
2012-01-01
We construct a general class of pseudo-Goldstone composite Higgs models, within the minimal $SO(5)/SO(4)$ coset structure, that are not necessarily of moose-type. We characterize the main properties these models should have in order to give rise to a Higgs mass at around 125 GeV. We assume the existence of relatively light and weakly coupled spin 1 and 1/2 resonances. In absence of a symmetry principle, we introduce the Minimal Higgs Potential (MHP) hypothesis: the Higgs potential is assumed to be one-loop dominated by the SM fields and the above resonances, with a contribution that is made calculable by imposing suitable generalizations of the first and second Weinberg sum rules. We show that a 125 GeV Higgs requires light, often sub-TeV, fermion resonances. Their presence can also be important for the model to successfully pass the electroweak precision tests. Interestingly enough, the latter can be passed also by models with a heavy Higgs around 320 GeV. The composite Higgs models of the moose-type conside...
Generalized Nonlinear Yule Models
Lansky, Petr; Polito, Federico; Sacerdote, Laura
2016-10-01
With the aim of considering models related to random graphs growth exhibiting persistent memory, we propose a fractional nonlinear modification of the classical Yule model often studied in the context of macroevolution. Here the model is analyzed and interpreted in the framework of the development of networks such as the World Wide Web. Nonlinearity is introduced by replacing the linear birth process governing the growth of the in-links of each specific webpage with a fractional nonlinear birth process with completely general birth rates. Among the main results we derive the explicit distribution of the number of in-links of a webpage chosen uniformly at random recognizing the contribution to the asymptotics and the finite time correction. The mean value of the latter distribution is also calculated explicitly in the most general case. Furthermore, in order to show the usefulness of our results, we particularize them in the case of specific birth rates giving rise to a saturating behaviour, a property that is often observed in nature. The further specialization to the non-fractional case allows us to extend the Yule model accounting for a nonlinear growth.
Generalized Nonlinear Yule Models
Lansky, Petr; Polito, Federico; Sacerdote, Laura
2016-11-01
With the aim of considering models related to random graphs growth exhibiting persistent memory, we propose a fractional nonlinear modification of the classical Yule model often studied in the context of macroevolution. Here the model is analyzed and interpreted in the framework of the development of networks such as the World Wide Web. Nonlinearity is introduced by replacing the linear birth process governing the growth of the in-links of each specific webpage with a fractional nonlinear birth process with completely general birth rates. Among the main results we derive the explicit distribution of the number of in-links of a webpage chosen uniformly at random recognizing the contribution to the asymptotics and the finite time correction. The mean value of the latter distribution is also calculated explicitly in the most general case. Furthermore, in order to show the usefulness of our results, we particularize them in the case of specific birth rates giving rise to a saturating behaviour, a property that is often observed in nature. The further specialization to the non-fractional case allows us to extend the Yule model accounting for a nonlinear growth.
Introduction to general and generalized linear models
Madsen, Henrik
2010-01-01
IntroductionExamples of types of data Motivating examples A first view on the modelsThe Likelihood PrincipleIntroduction Point estimation theory The likelihood function The score function The information matrix Alternative parameterizations of the likelihood The maximum likelihood estimate (MLE) Distribution of the ML estimator Generalized loss-function and deviance Quadratic approximation of the log-likelihood Likelihood ratio tests Successive testing in hypothesis chains Dealing with nuisance parameters General Linear ModelsIntroduction The multivariate normal distribution General linear mod
In vivo models for male reproductive toxicology.
Tyl, Rochelle W
2002-05-01
In Vivo Models for Male Reproductive Toxicology (Rochelle W. Tyl, Research Triangle Institute, Research Triangle Park, North Carolina). Assessment of male reproductive function requires a specific set of evaluations of the various steps in successful mating from sperm production to copulation to fertilization to production of a viable litter. This unit outlines the measurements that are standard for determining the effects of treatment with toxicant on the reproductive capacity of male mice and rats.
Mouse models in male fertility research
Institute of Scientific and Technical Information of China (English)
Duangporn Jamsai; Moira K O'Bryan
2011-01-01
Limited knowledge of the genetic causes of male infertility has resulted in few treatment and targeted therapeutic options.Although the ideal approach to identify infertility causing mutations is to conduct studies in the human population,this approach has progressed slowly due to the limitations described herein.Given the complexity of male fertility,the entire process cannot be modeled in vitro.As such,animal models,in particular mouse models,provide a valuable alternative for gene identification and experimentation.Since the introduction of molecular biology and recent advances in animal model production,there has been a substantial acceleration in the identification and characterization of genes associated with many diseases,including infertility.Three major types of mouse models are commonly used in biomedical research,including knockout/knockin/gene-trapped,transgenic and chemical-induced point mutant mice.Using these mouse models,over 400 genes essential for male fertility have been revealed.It has,however,been estimated that thousands of genes are involved in the regulation of the complex process of male fertility,as many such genes remain to be characterized.The current review is by no means a comprehensive list of these mouse models,rather it contains examples of how mouse models have advanced our knowledge of post-natal germ cell development and male fertility regulation.
Male gametophyte development and function in angiosperms: a general concept.
Hafidh, Said; Fíla, Jan; Honys, David
2016-06-01
Overview of pollen development. Male gametophyte development of angiosperms is a complex process that requires coordinated activity of different cell types and tissues of both gametophytic and sporophytic origin and the appropriate specific gene expression. Pollen ontogeny is also an excellent model for the dissection of cellular networks that control cell growth, polarity, cellular differentiation and cell signaling. This article describes two sequential phases of angiosperm pollen ontogenesis-developmental phase leading to the formation of mature pollen grains, and a functional or progamic phase, beginning with the impact of the grains on the stigma surface and ending at double fertilization. Here we present an overview of important cellular processes in pollen development and explosive pollen tube growth stressing the importance of reserves accumulation and mobilization and also the mutual activation of pollen tube and pistil tissues, pollen tube guidance and the communication between male and female gametophytes. We further describe the recent advances in regulatory mechanisms involved such as posttranscriptional regulation (including mass transcript storage) and posttranslational modifications to modulate protein function, intracellular metabolic signaling, ionic gradients such as Ca(2+) and H(+) ions, cell wall synthesis, protein secretion and intercellular signaling within the reproductive tissues.
Generalized, Linear, and Mixed Models
McCulloch, Charles E; Neuhaus, John M
2011-01-01
An accessible and self-contained introduction to statistical models-now in a modernized new editionGeneralized, Linear, and Mixed Models, Second Edition provides an up-to-date treatment of the essential techniques for developing and applying a wide variety of statistical models. The book presents thorough and unified coverage of the theory behind generalized, linear, and mixed models and highlights their similarities and differences in various construction, application, and computational aspects.A clear introduction to the basic ideas of fixed effects models, random effects models, and mixed m
"Aging males" symptoms and general health of adult males: a cross-sectional study.
Yuen, John W; Ng, Chi-Fai; Chiu, Peter Ka Fung; Teoh, Jeremy Yuen Chun; Yee, C H
2016-06-01
A cross-sectional study was conducted to explore the prevalence and severity of health-related complaints perceived by adult males of Hong Kong by using the Hong Kong Traditional Chinese versions of the Aging males' symptoms (AMS) scale and the 5-dimensional and 3-level European Quality of life (EQ-5D-3L) questionnaire. A total of 825 adult males aged 40 years or above were surveyed, and observed that 80% of the population was living with little-to-mild levels of aging symptoms with mean total scores ranged between 26.02 ± 7.91 and 32.99 ± 7.91 in different age groups. Such symptoms were correlated with age, especially for the somato-vegetative and sexual symptoms. The most severe AMS symptoms were observed in the oldest age group at 70 years or above, with 76%, 34% and 70% living with moderate-to-severe levels of somato-vegetative, psychological and sexual symptoms, respectively. The result was highly correlated with the EQ-5D-3L questionnaire. Secondly, the Hong Kong Aging males' symptoms (AMS) scale was shown to have good reliability with test-retest coefficient at 0.79 (ranged 0.66-0.87) and Cronbach's alpha coefficient at 0.88 (ranged 0.70-0.84). In summary, the population of Hong Kong male adults was commonly living with little-to-mild levels of aging symptoms, whereas their severity was correlated with age.
Sexuality After Cancer: A Model for Male Survivors.
Katz, Anne; Dizon, Don S
2016-01-01
For men with cancer, sexual dysfunction is a common issue and has a negative impact on quality of life, regardless of whether he has a partner. In general, sexuality encompasses much more than intercourse; it involves body image, identity, romantic and sexual attraction, and sexual thoughts and fantasies. Acknowledging that cancer affects multiple physical and psychosocial domains in patients, the authors propose that such changes also inform sexual function for the male survivor. An in-depth review of the literature describing alterations to sexual functioning in men with cancer was undertaken. Based on this and the clinical expertise of the authors, a new model was created and is presented. This biopsychosocial model is intended to expand the understanding of male sexuality beyond a purely biomedical model that addresses dysfunction as distinct from the context of a man's life and sexual identity. Most data on sexual dysfunction in men with cancer are derived from those with a history of prostate cancer, although other data suggest that men with other types of malignancies are similarly affected. Unfortunately, male sexuality is often reduced to aspects of erection and performance. Acknowledging that cancer affects multiple physical and psychosocial domains in patients, the authors propose that such changes also inform sexual function for the male survivor. This biopsychosocial model might form the basis for interventions for sexual problems after cancer that includes a man and his partner as a complex whole. Copyright © 2016 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.
Koeijers, J.J.; Verbon, A.; Kessels, A.G.H.; Bartelds, A.; Donker, G.; Nys, S.; Stobberingh, E.E.
2010-01-01
Objectives: To evaluate uropathogens and their antibiotic susceptibility in male general practitioner (GP) patients presenting with an uncomplicated urinary tract infection (UTI). Material and Methods: A population-based study was conducted among males, 18 years and older, general practice patients,
Fermions as generalized Ising models
Wetterich, C.
2017-04-01
We establish a general map between Grassmann functionals for fermions and probability or weight distributions for Ising spins. The equivalence between the two formulations is based on identical transfer matrices and expectation values of products of observables. The map preserves locality properties and can be realized for arbitrary dimensions. We present a simple example where a quantum field theory for free massless Dirac fermions in two-dimensional Minkowski space is represented by an asymmetric Ising model on a euclidean square lattice.
CPN Models in General Coordinates
Barnes, K J
2002-01-01
An analysis of CPN models is given in terms of general coordinates or arbitrary interpolating fields.Only closed expressions made from simple functions are involved.Special attention is given to CP2 and CP4. In the first of these the retrieval of stereographic coordinates reveals the hermitian form of the metric. A similar analysis for the latter case allows comparison with the Fubini-Study metric.
Multivariate covariance generalized linear models
DEFF Research Database (Denmark)
Bonat, W. H.; Jørgensen, Bent
2016-01-01
We propose a general framework for non-normal multivariate data analysis called multivariate covariance generalized linear models, designed to handle multivariate response variables, along with a wide range of temporal and spatial correlation structures defined in terms of a covariance link...... function combined with a matrix linear predictor involving known matrices. The method is motivated by three data examples that are not easily handled by existing methods. The first example concerns multivariate count data, the second involves response variables of mixed types, combined with repeated...... are fitted by using an efficient Newton scoring algorithm based on quasi-likelihood and Pearson estimating functions, using only second-moment assumptions. This provides a unified approach to a wide variety of types of response variables and covariance structures, including multivariate extensions...
Ortner, Tuulia M.; Vormittag, Isabella
2011-01-01
Effects of test administrator's gender on test takers' self-estimated verbal general knowledge and de facto verbal general knowledge were investigated. Based on three theories previously applied in research dealing with the effects of test administrator's ethnicity, it was expected male and female test takers to show higher scores under female…
Fermions as generalized Ising models
Directory of Open Access Journals (Sweden)
C. Wetterich
2017-04-01
Full Text Available We establish a general map between Grassmann functionals for fermions and probability or weight distributions for Ising spins. The equivalence between the two formulations is based on identical transfer matrices and expectation values of products of observables. The map preserves locality properties and can be realized for arbitrary dimensions. We present a simple example where a quantum field theory for free massless Dirac fermions in two-dimensional Minkowski space is represented by an asymmetric Ising model on a euclidean square lattice.
Tandan, Meera; Duane, Sinead; Cormican, Martin; Murphy, Andrew W.; Vellinga, Akke
2016-01-01
Current antimicrobial prescribing guidelines indicate that male and female patients with urinary tract infections (UTIs) should be treated with same antimicrobials but for different durations. The aim of this study was to explore the differences in reconsultations and antimicrobial prescribing for UTI for both males and females. A total of 2557 adult suspected UTI patients participating in the Supporting the Improvement and Management of Prescribing for urinary tract infection (SIMPle) study from 30 general practices were analyzed. An antimicrobial was prescribed significantly more often to females (77%) than males (63%). Nitrofurantoin was prescribed more often for females and less often for males (58% vs. 41%), while fluoroquinolones were more often prescribed for males (11% vs. 3%). Overall, reconsultation was 1.4 times higher in females, and if the antimicrobial prescribed was not the recommended first-line (nitrofurantoin), reconsultation after empirical prescribing was significantly higher. However, the reconsultation was similar for males and females if the antimicrobial prescribed was first-line. When a urine culture was obtained, a positive culture was the most important predictor of reconsultation (Odds ratio 1.8 (95% CI 1.3–2.5)). This suggests, when prescribing empirically, that male and female UTI patients should initially be treated with first-line antimicrobials (nitrofurantoin) with different durations (50–100 mg four times daily for three days in females and seven days for males). However, the consideration of a culture test before prescribing antimicrobials may improve outcomes. PMID:27649253
Generalized model of island biodiversity
Kessler, David A.; Shnerb, Nadav M.
2015-04-01
The dynamics of a local community of competing species with weak immigration from a static regional pool is studied. Implementing the generalized competitive Lotka-Volterra model with demographic noise, a rich dynamics with four qualitatively distinct phases is unfolded. When the overall interspecies competition is weak, the island species recapitulate the mainland species. For higher values of the competition parameter, the system still admits an equilibrium community, but now some of the mainland species are absent on the island. Further increase in competition leads to an intermittent "disordered" phase, where the dynamics is controlled by invadable combinations of species and the turnover rate is governed by the migration. Finally, the strong competition phase is glasslike, dominated by uninvadable states and noise-induced transitions. Our model contains, as a special case, the celebrated neutral island theories of Wilson-MacArthur and Hubbell. Moreover, we show that slight deviations from perfect neutrality may lead to each of the phases, as the Hubbell point appears to be quadracritical.
Lukács, Liza; Murányi, István; Túry, Ferenc
2007-02-01
Pathological eating attitudes and extreme weight control practices occur most commonly in certain female populations. In some young male occupation groups, such as in the armed forces, the appearance of physical strength and muscularity has particular importance. We studied body and eating attitudes and the prevalence of bodybuilding and steroid abuse in 480 military college and 752 general college male students. The Eating Disorder Inventory was used for all subjects. General college students had higher body mass index values than did military students. The prevalence of bodybuilding and steroid abuse was significantly greater in the military population. Comparisons between the study groups and within groups showed significantly different scores on certain Eating Disorder Inventory subscales. The study revealed that male military college students have some protective factors against the psychopathological features of eating disorders.
Generalization performance of regularized neural network models
DEFF Research Database (Denmark)
Larsen, Jan; Hansen, Lars Kai
1994-01-01
Architecture optimization is a fundamental problem of neural network modeling. The optimal architecture is defined as the one which minimizes the generalization error. This paper addresses estimation of the generalization performance of regularized, complete neural network models. Regularization...
Generalized complex geometry, generalized branes and the Hitchin sigma model
Energy Technology Data Exchange (ETDEWEB)
Zucchini, Roberto E-mail: zucchinir@bo.infn.it
2005-03-01
Hitchin's generalized complex geometry has been shown to be relevant in compactifications of superstring theory with fluxes and is expected to lead to a deeper understanding of mirror symmetry. Gualtieri's notion of generalized complex submanifold seems to be a natural candidate for the description of branes in this context. Recently, we introduced a Batalin-Vilkovisky field theoretic realization of generalized complex geometry, the Hitchin sigma model, extending the well known Poisson sigma model. In this paper, exploiting Gualtieri's formalism, we incorporate branes into the model. A detailed study of the boundary conditions obeyed by the world sheet fields is provided. Finally, it is found that, when branes are present, the classical Batalin-Vilkovisky cohomology contains an extra sector that is related non trivially to a novel cohomology associated with the branes as generalized complex submanifolds. (author)
Generalized complex geometry, generalized branes and the Hitchin sigma model
Zucchini, R
2005-01-01
Hitchin's generalized complex geometry has been shown to be relevant in compactifications of superstring theory with fluxes and is expected to lead to a deeper understanding of mirror symmetry. Gualtieri's notion of generalized complex submanifold seems to be a natural candidate for the description of branes in this context. Recently, we introduced a field theoretic realization of generalized complex geometry, the Hitchin sigma model, extending the well known Poisson sigma model. In this paper, exploiting Gualtieri's formalism, we incorporate branes into the model. A detailed study of the boundary conditions obeyed by the world sheet fields is provided. Finally, it is found that, when branes are present, the classical Batalin--Vilkovisky cohomology contains an extra sector that is related non trivially to a novel cohomology associated with the branes as generalized complex submanifolds.
Overweight in young males reduce fertility in rabbit model
National Research Council Canada - National Science Library
Francisco Marco-Jiménez; José Salvador Vicente
2017-01-01
... parameters and fertility success in randomized controlled trial in a rabbit model. Fourteen male rabbits were randomly assigned to a control group in which nutritional requirements were satisfied or a group fed...
More on generalized Heisenberg ferromagnet models
Oh, P; Oh, Phillial; Park, Q Han
1996-01-01
We generalize the integrable Heisenberg ferromagnet model according to each Hermitian symmetric spaces and address various new aspects of the generalized model. Using the first order formalism of generalized spins which are defined on the coadjoint orbits of arbitrary groups, we construct a Lagrangian of the generalized model from which we obtain the Hamiltonian structure explicitly in the case of CP(N-1) orbit. The gauge equivalence between the generalized Heisenberg ferromagnet and the nonlinear Schr\\"{o}dinger models is given. Using the equivalence, we find infinitely many conserved integrals of both models.
Product model structure for generalized optimal design
Institute of Scientific and Technical Information of China (English)
无
2002-01-01
The framework of the generalized optimization product model with the core of network- and tree-hierarchical structure is advanced to improve the characteristics of the generalized optimal design. Based on the proposed node-repetition technique, a network-hierarchical structure is united with the tree-hierarchical structure to facilitate the modeling of serialization and combination products. The criteria for product decomposition are investigated. Seven tree nodes are defined for the construction of a general product model, and their modeling properties are studied in detail. The developed product modeling system is applied and examined successfully in the modeling practice of the generalized optimal design for a hydraulic excavator.
Chin-Yu Liu; Yu-Ching Chou; Jane C-J Chao; Chien-Yeh Hsu; Tai-Lung Cha; Chih-Wei Tsao
2015-01-01
Objective To explore the associations between different dietary patterns and semen quality in a general Asian male population. Methods Cross-sectional study. Healthy Taiwanese men aged 18 years or older who participated in a standard medical screening program from 2008-2013 run by a private firm were included in this study. Semen parameters including sperm concentration (SC), total sperm motility (TSM), progressive motility (PRM) and normal sperm morphology (NSM) were recorded. A dietary ques...
Multivariate generalized linear mixed models using R
Berridge, Damon Mark
2011-01-01
Multivariate Generalized Linear Mixed Models Using R presents robust and methodologically sound models for analyzing large and complex data sets, enabling readers to answer increasingly complex research questions. The book applies the principles of modeling to longitudinal data from panel and related studies via the Sabre software package in R. A Unified Framework for a Broad Class of Models The authors first discuss members of the family of generalized linear models, gradually adding complexity to the modeling framework by incorporating random effects. After reviewing the generalized linear model notation, they illustrate a range of random effects models, including three-level, multivariate, endpoint, event history, and state dependence models. They estimate the multivariate generalized linear mixed models (MGLMMs) using either standard or adaptive Gaussian quadrature. The authors also compare two-level fixed and random effects linear models. The appendices contain additional information on quadrature, model...
Relationship between general and specific coordination in 8- to 17-year-old male basketball players.
Kamandulis, Sigitas; Venckūnas, Tomas; Masiulis, Nerijus; Matulaitis, Kestutis; Balciūnas, Mindaugas; Peters, Derek; Skurvydas, Albertas
2013-12-01
The purpose of the present study was to investigate the relationships between general coordination, sport-specific coordination, and sport-specific fitness of 8- to 17-year-old male basketball players. 312 males with training experience ranging from one year in the 8-year-old cohort up to 10 years for the 17-year-olds performed basketball-specific fitness (20 m sprint, Illinois, countermovement jump), general coordination (20 m run with three obstacles), semi-basketball-specific coordination (20 m sprint dribbling two balls, countermovement jump with arm swing) and basketball-specific coordination (Illinois ball dribbling) tests. There were moderate to large correlations between the results of both general and basketball-specific coordination with the results of most basketball-specific coordination tests in all age groups. Correlations between general and basketball-specific coordination were large in four age groups (11-14 yr., r = .52 to r = .76), moderate in five groups (8-10, 15 & 16 yr., r = .37 to r = .46), while not significant in the 17-year-olds. These results suggest that the importance of general coordination for sport-specific skills improvements during a sports-specific skill acquisition phase, remains high at the skill refinement phase, and decreases when sport-specific skills have been mastered to near-perfection.
Aspects of generalized Calogero model
Meljanac, S; Milekovic, M
2004-01-01
A multispecies model of Calogero type in $D\\geq 1$ dimensions is constructed. The model includes harmonic, two-body and three-body interactions. Using the underlying conformal SU(1,1) algebra, we find the exact eigenenergies corresponding to a class of the exact global collective states. Analysing corresponding Fock space, we detect the universal critical point at which the model exhibits singular behaviour.
Generalized exponential function and discrete growth models
Souto Martinez, Alexandre; Silva González, Rodrigo; Lauri Espíndola, Aquino
2009-07-01
Here we show that a particular one-parameter generalization of the exponential function is suitable to unify most of the popular one-species discrete population dynamic models into a simple formula. A physical interpretation is given to this new introduced parameter in the context of the continuous Richards model, which remains valid for the discrete case. From the discretization of the continuous Richards’ model (generalization of the Gompertz and Verhulst models), one obtains a generalized logistic map and we briefly study its properties. Notice, however that the physical interpretation for the introduced parameter persists valid for the discrete case. Next, we generalize the (scramble competition) θ-Ricker discrete model and analytically calculate the fixed points as well as their stabilities. In contrast to previous generalizations, from the generalized θ-Ricker model one is able to retrieve either scramble or contest models.
General introduction to simulation models
DEFF Research Database (Denmark)
Hisham Beshara Halasa, Tariq; Boklund, Anette
2012-01-01
Monte Carlo simulation can be defined as a representation of real life systems to gain insight into their functions and to investigate the effects of alternative conditions or actions on the modeled system. Models are a simplification of a system. Most often, it is best to use experiments and field...
Inhomogeneous generalization of some Bianchi models
Carmeli, M.; Charach, Ch.
1980-02-01
Vacuum Bianchi models which can be transformed to the Einstein-Rosen metric are considered. The models are used in order to construct new inhomogeneous universes, which are generalizations of Bianchi cosmologies of types III, V and VIh. Recent generalizations of these Bianchi models, considered by Wainwright et al., are also discussed.
Theoretical Models of Generalized Quasispecies.
Wagner, Nathaniel; Atsmon-Raz, Yoav; Ashkenasy, Gonen
2016-01-01
Theoretical modeling of quasispecies has progressed in several directions. In this chapter, we review the works of Emmanuel Tannenbaum, who, together with Eugene Shakhnovich at Harvard University and later with colleagues and students at Ben-Gurion University in Beersheva, implemented one of the more useful approaches, by progressively setting up various formulations for the quasispecies model and solving them analytically. Our review will focus on these papers that have explored new models, assumed the relevant mathematical approximations, and proceeded to analytically solve for the steady-state solutions and run stochastic simulations . When applicable, these models were related to real-life problems and situations, including changing environments, presence of chemical mutagens, evolution of cancer and tumor cells , mutations in Escherichia coli, stem cells , chromosomal instability (CIN), propagation of antibiotic drug resistance , dynamics of bacteria with plasmids , DNA proofreading mechanisms, and more.
General Pressurization Model in Simscape
Servin, Mario; Garcia, Vicky
2010-01-01
System integration is an essential part of the engineering design process. The Ares I Upper Stage (US) is a complex system which is made up of thousands of components assembled into subsystems including a J2-X engine, liquid hydrogen (LH2) and liquid oxygen (LO2) tanks, avionics, thrust vector control, motors, etc. System integration is the task of connecting together all of the subsystems into one large system. To ensure that all the components will "fit together" as well as safety and, quality, integration analysis is required. Integration analysis verifies that, as an integrated system, the system will behave as designed. Models that represent the actual subsystems are built for more comprehensive analysis. Matlab has been an instrument widely use by engineers to construct mathematical models of systems. Simulink, one of the tools offered by Matlab, provides multi-domain graphical environment to simulate and design time-varying systems. Simulink is a powerful tool to analyze the dynamic behavior of systems over time. Furthermore, Simscape, a tool provided by Simulink, allows users to model physical (such as mechanical, thermal and hydraulic) systems using physical networks. Using Simscape, a model representing an inflow of gas to a pressurized tank was created where the temperature and pressure of the tank are measured over time to show the behavior of the gas. By further incorporation of Simscape into model building, the full potential of this software can be discovered and it hopefully can become a more utilized tool.
Cosmological models in general relativity
Indian Academy of Sciences (India)
B B Paul
2003-12-01
LRS Bianchi type-I space-time ﬁlled with perfect ﬂuid is considered here with deceleration parameter as variable. The metric potentials and are functions of as well as . Assuming '/=(), where prime denotes differentiation with respect to , it was found that =('/) and =(), where =() and is the scale factor which is a function of only. The value of Hubble’s constant 0 was found to be less than half for non-ﬂat model and is equal to 1.3 for a ﬂat model.
Generalized Kripke models for epistemic logic
Voorbraak, F.
In this paper a generalization of Kripke models is proposed for systemizing the study of the many different epistemic notions that appear in the literature. The generalized Kripke models explicitly represent an agent's epistemic states to which the epistemic notions refer. Two central
Generalized Kripke models for epistemic logic
Voorbraak, F.
2008-01-01
In this paper a generalization of Kripke models is proposed for systemizing the study of the many different epistemic notions that appear in the literature. The generalized Kripke models explicitly represent an agent's epistemic states to which the epistemic notions refer. Two central epistemic noti
General Geographical Economics Model with Congestion
J.G.M. van Marrewijk (Charles)
2005-01-01
textabstractWe derive and discuss a general, but simple geographical economics model with congestion, allowing us to explain the economic viability of small and large locations. The model generalizes some previous work and lends itself to analyzing the impact of public policy in terms of
Awareness of human papillomavirus in 23 000 Danish men from the general male population
DEFF Research Database (Denmark)
Nielsen, Ann; Munk, Christian; Liaw, Kai-Li
2009-01-01
Men play an important role in transmission of human papillomavirus (HPV). Both in men and in women HPV causes great morbidity, such as cervical cancer, penile and anal cancer, and genital warts. The awareness of HPV and its consequences is essential to a successful vaccination program against HPV....... In this study, we assessed awareness of HPV in Danish men. A random sample of men aged 18-45 years from the general male population was invited to participate in the study. The participants filled in a self-administered questionnaire with questions concerning awareness of HPV, lifestyle, and sexual habits...
A general consumer-resource population model
Lafferty, Kevin D.; DeLeo, Giulio; Briggs, Cheryl J.; Dobson, Andrew P.; Gross, Thilo; Kuris, Armand M.
2015-01-01
Food-web dynamics arise from predator-prey, parasite-host, and herbivore-plant interactions. Models for such interactions include up to three consumer activity states (questing, attacking, consuming) and up to four resource response states (susceptible, exposed, ingested, resistant). Articulating these states into a general model allows for dissecting, comparing, and deriving consumer-resource models. We specify this general model for 11 generic consumer strategies that group mathematically into predators, parasites, and micropredators and then derive conditions for consumer success, including a universal saturating functional response. We further show how to use this framework to create simple models with a common mathematical lineage and transparent assumptions. Underlying assumptions, missing elements, and composite parameters are revealed when classic consumer-resource models are derived from the general model.
Anisotropic Generalized Ghost Pilgrim Dark Energy Model in General Relativity
Santhi, M. Vijaya; Rao, V. U. M.; Aditya, Y.
2017-02-01
A spatially homogeneous and anisotropic locally rotationally symmetric (LRS) Bianchi type- I Universe filled with matter and generalized ghost pilgrim dark energy (GGPDE) has been studied in general theory of relativity. To obtain determinate solution of the field equations we have used scalar expansion proportional to the shear scalar which leads to a relation between the metric potentials. Some well-known cosmological parameters (equation of state (EoS) parameter ( ω Λ), deceleration parameter ( q) and squared speed of sound {vs2}) and planes (ω _{Λ }-dot {ω }_{Λ } and statefinder) are constructed for obtained model. The discussion and significance of these parameters is totally done through pilgrim dark energy parameter ( β) and cosmic time ( t).
Generalization error bounds for stationary autoregressive models
McDonald, Daniel J; Schervish, Mark
2011-01-01
We derive generalization error bounds for stationary univariate autoregressive (AR) models. We show that the stationarity assumption alone lets us treat the estimation of AR models as a regularized kernel regression without the need to further regularize the model arbitrarily. We thereby bound the Rademacher complexity of AR models and apply existing Rademacher complexity results to characterize the predictive risk of AR models. We demonstrate our methods by predicting interest rate movements.
A generalized sinusoidal model and its applications
Institute of Scientific and Technical Information of China (English)
KU Shao-ping; LI Ning
2009-01-01
A physical model of sinusoidal function was established. It is generalized that the force is directly proportional to a power function of the distance in a classical spring-oscillator system. The differential equation of the generalized model was given. Simulations were conducted with different power values. The results show that the solution of the generalized equation is a periodic function. The expressions of the amplitude and the period (frequency) of the generalized equation were derived by the physical method. All the simulation results coincide with the calculation results of the derived expressions. A special function also was deduced and proven to be convergent in the theoretical analysis. The limit value of the special function also was derived. The generalized model can be used in solving a type of differential equation and to generate periodic waveforms.
EOP MIT General Circulation Model (MITgcm)
National Oceanic and Atmospheric Administration, Department of Commerce — This data contains a regional implementation of the Massachusetts Institute of Technology general circulation model (MITgcm) at a 1-km spatial resolution for the...
Generalized Reduced Order Model Generation Project
National Aeronautics and Space Administration — M4 Engineering proposes to develop a generalized reduced order model generation method. This method will allow for creation of reduced order aeroservoelastic state...
Generalized Kahler Geometry from supersymmetric sigma models
Bredthauer, A; Persson, J; Zabzine, M; Bredthauer, Andreas; Lindstrom, Ulf; Persson, Jonas; Zabzine, Maxim
2006-01-01
We give a physical derivation of generalized Kahler geometry. Starting from a supersymmetric nonlinear sigma model, we rederive and explain the results of Gualtieri regarding the equivalence between generalized Kahler geometry and the bi-hermitean geometry of Gates-Hull-Rocek. When cast in the language of supersymmetric sigma models, this relation maps precisely to that between the Lagrangian and the Hamiltonian formalisms. We also discuss topological twist in this context.
Generalized latent variable modeling multilevel, longitudinal, and structural equation models
Skrondal, Anders
2004-01-01
METHODOLOGY THE OMNI-PRESENCE OF LATENT VARIABLES Introduction 'True' variable measured with error Hypothetical constructs Unobserved heterogeneity Missing values and counterfactuals Latent responses Generating flexible distributions Combining information Summary MODELING DIFFERENT RESPONSE PROCESSES Introduction Generalized linear models Extensions of generalized linear models Latent response formulation Modeling durations or survival Summary and further reading CLASSICAL LATENT VARIABLE MODELS Introduction Multilevel regression models Factor models and item respons
Empirical generalization assessment of neural network models
DEFF Research Database (Denmark)
Larsen, Jan; Hansen, Lars Kai
1995-01-01
competing models. Since all models are trained on the same data, a key issue is to take this dependency into account. The optimal split of the data set of size N into a cross-validation set of size Nγ and a training set of size N(1-γ) is discussed. Asymptotically (large data sees), γopt→1......This paper addresses the assessment of generalization performance of neural network models by use of empirical techniques. We suggest to use the cross-validation scheme combined with a resampling technique to obtain an estimate of the generalization performance distribution of a specific model...
Foundations of linear and generalized linear models
Agresti, Alan
2015-01-01
A valuable overview of the most important ideas and results in statistical analysis Written by a highly-experienced author, Foundations of Linear and Generalized Linear Models is a clear and comprehensive guide to the key concepts and results of linear statistical models. The book presents a broad, in-depth overview of the most commonly used statistical models by discussing the theory underlying the models, R software applications, and examples with crafted models to elucidate key ideas and promote practical model building. The book begins by illustrating the fundamentals of linear models,
All the generalized Georgi-Machacek models
Logan, Heather E
2015-01-01
The Georgi-Machacek model adds two SU(2)_L-triplet scalars to the Standard Model in such a way as to preserve custodial SU(2) symmetry. We study the generalizations of the Georgi-Machacek model to SU(2)_L representations larger than triplets. Perturbative unitarity considerations limit the possibilities to models containing only SU(2)_L quartets, quintets, or sextets. These models are phenomenologically interesting because they allow the couplings of the 125 GeV Higgs boson to WW and ZZ to be larger than their values in the Standard Model. We write down the most general custodial SU(2)-preserving scalar potentials for these models and outline their phenomenology. We find that experimental and theoretical constraints on the fermiophobic custodial-fiveplet states present in each of the models lead to absolute upper bounds on the 125 GeV Higgs boson coupling strength to WW and ZZ.
Simple implementation of general dark energy models
Energy Technology Data Exchange (ETDEWEB)
Bloomfield, Jolyon K. [MIT Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, 77 Massachusetts Ave #37241, Cambridge, MA, 02139 (United States); Pearson, Jonathan A., E-mail: jolyon@mit.edu, E-mail: jonathan.pearson@durham.ac.uk [Centre for Particle Theory, Department of Mathematical Sciences, Durham University, South Road, Durham, DH1 3LE (United Kingdom)
2014-03-01
We present a formalism for the numerical implementation of general theories of dark energy, combining the computational simplicity of the equation of state for perturbations approach with the generality of the effective field theory approach. An effective fluid description is employed, based on a general action describing single-scalar field models. The formalism is developed from first principles, and constructed keeping the goal of a simple implementation into CAMB in mind. Benefits of this approach include its straightforward implementation, the generality of the underlying theory, the fact that the evolved variables are physical quantities, and that model-independent phenomenological descriptions may be straightforwardly investigated. We hope this formulation will provide a powerful tool for the comparison of theoretical models of dark energy with observational data.
Male sexual strategies modify ratings of female models with specific waist-to-hip ratios.
Brase, Gary L; Walker, Gary
2004-06-01
Female waist-to-hip ratio (WHR) has generally been an important general predictor of ratings of physical attractiveness and related characteristics. Individual differences in ratings do exist, however, and may be related to differences in the reproductive tactics of the male raters such as pursuit of short-term or long-term relationships and adjustments based on perceptions of one's own quality as a mate. Forty males, categorized according to sociosexual orientation and physical qualities (WHR, Body Mass Index, and self-rated desirability), rated female models on both attractiveness and likelihood they would approach them. Sociosexually restricted males were less likely to approach females rated as most attractive (with 0.68-0.72 WHR), as compared with unrestricted males. Males with lower scores in terms of physical qualities gave ratings indicating more favorable evaluations of female models with lower WHR. The results indicate that attractiveness and willingness to approach are overlapping but distinguishable constructs, both of which are influenced by variations in characteristics of the raters.
Micro Data and General Equilibrium Models
DEFF Research Database (Denmark)
Browning, Martin; Hansen, Lars Peter; Heckman, James J.
1999-01-01
Dynamic general equilibrium models are required to evaluate policies applied at the national level. To use these models to make quantitative forecasts requires knowledge of an extensive array of parameter values for the economy at large. This essay describes the parameters required for different ...
Resonance asymptotics in the generalized Winter model
Exner, P; Exner, Pavel; Fraas, Martin
2006-01-01
We consider a modification of the Winter model describing a quantum particle in presence of a spherical barrier given by a fixed generalized point interaction. It is shown that the three classes of such interactions correspond to three different types of asymptotic behaviour of resonances of the model at high energies.
Engqvist, Leif
2013-05-01
A complete understanding of male reproductive success, and thus sexual selection, often requires an insight into male success in sperm competition. Genuine conclusions on male sperm competitiveness can only be made in real competitive situations. However, statistical analyses of sperm competitiveness from fertilization success data have been shown to be problematic. Here, I first outline a comprehensive general description of the different additive and nonadditive elements relevant for the outcome of sperm competition staged between two males. Based on this description, I will highlight two main problems that are frequently encountered in experiments aiming at estimating sperm competitiveness. First, I focus on potential problems when using standardized competitors versus random mating trials, because trials with standardized competitors do not allow generalization if male-male interactions are important. Second, I illustrate the necessity to analyze data on the logit scale rather than on raw proportions, because only the logit scale allows a clean separation of additive and nonadditive effects (i.e., male × male and female × male interactions).
A general model for bidirectional associative memories.
Shi, H; Zhao, Y; Zhuang, X
1998-01-01
This paper proposes a general model for bidirectional associative memories that associate patterns between the X-space and the Y-space. The general model does not require the usual assumption that the interconnection weight from a neuron in the X-space to a neuron in the Y-space is the same as the one from the Y-space to the X-space. We start by defining a supporting function to measure how well a state supports another state in a general bidirectional associative memory (GBAM). We then use the supporting function to formulate the associative recalling process as a dynamic system, explore its stability and asymptotic stability conditions, and develop an algorithm for learning the asymptotic stability conditions using the Rosenblatt perceptron rule. The effectiveness of the proposed model for recognition of noisy patterns and the performance of the model in terms of storage capacity, attraction, and spurious memories are demonstrated by some outstanding experimental results.
Modelling the Progression of Male Swimmers’ Performances through Adolescence
Directory of Open Access Journals (Sweden)
Shilo J. Dormehl
2016-01-01
Full Text Available Insufficient data on adolescent athletes is contributing to the challenges facing youth athletic development and accurate talent identification. The purpose of this study was to model the progression of male sub-elite swimmers’ performances during adolescence. The performances of 446 males (12–19 year olds competing in seven individual events (50, 100, 200 m freestyle, 100 m backstroke, breaststroke, butterfly, 200 m individual medley over an eight-year period at an annual international schools swimming championship, run under FINA regulations were collected. Quadratic functions for each event were determined using mixed linear models. Thresholds of peak performance were achieved between the ages of 18.5 ± 0.1 (50 m freestyle and 200 m individual medley and 19.8 ± 0.1 (100 m butterfly years. The slowest rate of improvement was observed in the 200 m individual medley (20.7% and the highest in the 100 m butterfly (26.2%. Butterfly does however appear to be one of the last strokes in which males specialise. The models may be useful as talent identification tools, as they predict the age at which an average sub-elite swimmer could potentially peak. The expected rate of improvement could serve as a tool in which to monitor and evaluate benchmarks.
The Cosmology of Generalized Modified Gravity Models
Carroll, S M; Duvvuri, V; Easson, D A; Trodden, M; Turner, M S; Carroll, Sean M.; Felice, Antonio De; Duvvuri, Vikram; Easson, Damien A.; Trodden, Mark; Turner, Michael S.
2005-01-01
We consider general curvature-invariant modifications of the Einstein-Hilbert action that become important only in regions of extremely low space-time curvature. We investigate the far future evolution of the universe in such models, examining the possibilities for cosmic acceleration and other ultimate destinies. The models generically possess de Sitter space as an unstable solution and exhibit an interesting set of attractor solutions which, in some cases, provide alternatives to dark energy models.
Cosmology of generalized modified gravity models
Carroll, Sean M.; de Felice, Antonio; Duvvuri, Vikram; Easson, Damien A.; Trodden, Mark; Turner, Michael S.
2005-03-01
We consider general curvature-invariant modifications of the Einstein-Hilbert action that become important only in regions of extremely low space-time curvature. We investigate the far future evolution of the Universe in such models, examining the possibilities for cosmic acceleration and other ultimate destinies. The models generically possess de Sitter space as an unstable solution and exhibit an interesting set of attractor solutions which, in some cases, provide alternatives to dark energy models.
The generic model of General Relativity
Energy Technology Data Exchange (ETDEWEB)
Tsamparlis, Michael, E-mail: mtsampa@phys.uoa.g [Department of Physics, Section Astrophysics Astronomy Mechanics, University of Athens, University of Athens, Zografos 15783, Athens (Greece)
2009-10-01
We develop a generic spacetime model in General Relativity from which all existing model results are produced under specific assumptions, depending on the case. We classify each type of possible assumption, especially the role of observers and that of symmetries, and discuss their role in the development of a model. We apply the results in a step by step approach to the case of a Bianchi I spacetime and a string fluid.
Interacting holographic generalized cosmic Chaplygin gas model
Naji, Jalil
2014-03-01
In this paper we consider a correspondence between the holographic dark energy density and interacting generalized cosmic Chaplygin gas energy density in flat FRW universe. Then, we reconstruct the potential of the scalar field which describe the generalized cosmic Chaplygin cosmology. In the special case we obtain time-dependent energy density and study cosmological parameters. We find stability condition of this model which is depend on cosmic parameter.
Exploring General and Sports Nutrition and Food Knowledge in Elite Male Australian Athletes.
Devlin, Brooke L; Belski, Regina
2015-06-01
Nutrition knowledge is believed to influence nutritional intake, which in turn influences performance in elite athletes. There is currently no published data on the nutrition knowledge of elite Australian Football (AF) players. The purpose of this study was to gain insight into the current level of general and sports nutrition knowledge in elite male AF athletes. Forty six elite male AF players (23.5 ± 2.8 years) answered 123 questions relating to five areas of nutrition knowledge: dietary recommendations, sources of nutrients, choosing everyday foods, alcohol and sports nutrition. Demographic details and perceptions of nutrition knowledge were collected for all participants. The mean nutrition knowledge score was 74.4 ± 10.9 (60.5%). The highest score was obtained in sports nutrition section (17.9 ± 3.0, 61.7%). The dietitian was selected as the first source of information by 98% of athletes, with club trainer and teammates as second choice for 45.7% and 23.9% of athletes, respectively. The majority of athletes correctly answered questions regarding recommendations to increase fruit and vegetable intake and decrease fat intake (95.6%, 91.1% and 93.3% correct respectively). While 80% of the athletes were aware fat intake should predominately be made up of unsaturated fat, they were less able to identify food sources of unsaturated fats (35.6% and 24.4% correct for statements regarding monounsaturated and polyunsaturated fats, respectively). Broad nutrition messages and recommendations appear to be well understood; however, gaps in nutrition knowledge are evident. A better understanding of nutrition knowledge in athletes will allow nutrition education interventions to target areas in need of improvement.
Multivariate Generalized Linear Mixed Models Using R
Berridge, Damon M
2011-01-01
To provide researchers with the ability to analyze large and complex data sets using robust models, this book presents a unified framework for a broad class of models that can be applied using a dedicated R package (Sabre). The first five chapters cover the analysis of multilevel models using univariate generalized linear mixed models (GLMMs). The next few chapters extend to multivariate GLMMs and the last chapters address more specialized topics, such as parallel computing for large-scale analyses. Each chapter includes many real-world examples implemented using Sabre as well as exercises and
Modelling anisotropic fluid spheres in general relativity
Boonserm, Petarpa; Visser, Matt
2015-01-01
We argue that an arbitrary general relativistic anisotropic fluid sphere, (spherically symmetric but with transverse pressure not equal to radial pressure), can nevertheless be successfully modelled by suitable linear combinations of quite ordinary classical matter: an isotropic perfect fluid, a classical electromagnetic field, and a classical (minimally coupled) scalar field. While the most general decomposition is not unique, a preferred minimal decomposition can be constructed that is unique. We show how the classical energy conditions for the anisotropic fluid sphere can be related to energy conditions for the isotropic perfect fluid, electromagnetic field, and scalar field components of the model. Furthermore we show how this decomposition relates to the distribution of electric charge density and scalar charge density throughout the model that is used to mimic the anisotropic fluid sphere. Consequently, we can build physically reasonable matter models for almost any spherically symmetric spacetime.
Generalized multicritical one-matrix models
Ambjorn, J; Makeenko, Y
2016-01-01
We show that there exists a simple generalization of Kazakov's multicritical one-matrix model, which interpolates between the various multicritical points of the model. The associated multicritical potential takes the form of a power series with a heavy tail, leading to a cut of the potential and its derivative at the real axis, and reduces to a polynomial at Kazakov's multicritical points. From the combinatorial point of view the generalized model allows polygons of arbitrary large degrees (or vertices of arbitrary large degree, when considering the dual graphs), and it is the weight assigned to these large order polygons which brings about the interpolation between the multicritical points in the one-matrix model.
Generalized multicritical one-matrix models
Ambjørn, J.; Budd, T.; Makeenko, Y.
2016-12-01
We show that there exists a simple generalization of Kazakov's multicritical one-matrix model, which interpolates between the various multicritical points of the model. The associated multicritical potential takes the form of a power series with a heavy tail, leading to a cut of the potential and its derivative at the real axis, and reduces to a polynomial at Kazakov's multicritical points. From the combinatorial point of view the generalized model allows polygons of arbitrary large degrees (or vertices of arbitrary large degree, when considering the dual graphs), and it is the weight assigned to these large order polygons which brings about the interpolation between the multicritical points in the one-matrix model.
On generalized P\\'olya urn models
Chen, May-Ru
2011-01-01
We study an urn model introduced in the paper of Chen and Wei, where at each discrete time step $m$ balls are drawn at random from the urn containing colors white and black. Balls are added to the urn according to the inspected colors, generalizing the well known P\\'olya-Eggenberger urn model, case m=1. We provide exact expressions for the expectation and the variance of the number of white balls after n draws, and determine the structure of higher moments. Moreover, we discuss extensions to more than two colors. Furthermore, we introduce and discuss a new urn model where the sampling of the m balls is carried out in a step-by-step fashion, and also introduce a generalized Friedman's urn model.
General Equilibrium Models: Improving the Microeconomics Classroom
Nicholson, Walter; Westhoff, Frank
2009-01-01
General equilibrium models now play important roles in many fields of economics including tax policy, environmental regulation, international trade, and economic development. The intermediate microeconomics classroom has not kept pace with these trends, however. Microeconomics textbooks primarily focus on the insights that can be drawn from the…
Experimental autoimmune orchitis as a model of immunological male infertility.
Naito, Munekazu; Terayama, Hayato; Hirai, Shuichi; Qu, Ning; Lustig, Livia; Itoh, Masahiro
2012-12-01
Clinically, 60-75% of male infertility cases are categorized as idiopathic spermatogenic disturbance. In previous studies of this condition, lymphocytic infiltration and immune deposits were present in several testis biopsy specimens, indicating that inflammatory or immunological factors contribute to the occurrence of the lesions. However, there is currently little evidence regarding immunological infertility in men. Previously, we established an immunological infertility model, experimental autoimmune orchitis (EAO), that can be induced in mice by two subcutaneous injections of viable syngeneic testicular germ cells without the use of any adjuvant. In this EAO model, lymphocytes surround the tubuli recti and then induce spermatogenic disturbance. In addition, after the active inflammation stage of this model, the seminiferous epithelium is damaged irreversibly, resembling the histopathology of human male idiopathic spermatogenic disturbance. In the majority of patients with testicular autoimmunity, there is a chronic and asymptomatic development of the inflammatory reaction. Therefore, this disease is very difficult to diagnose at the ongoing stage, and it is possible that the histopathology of idiopathic spermatogenic disturbance in the clinic is reported at the post-active inflammation stage of autoimmune orchitis. In this review, the histopathology of EAO before and after inflammation is discussed, comparing it with human orchitis.
Why Are Males Bad for Females? Models for the Evolution of Damaging Male Mating Behavior
Lessells, C.M.
2005-01-01
One explanation for the cost to mating for females caused by damaging male mating behavior is that this causes the females to adaptively modify their subsequent life histories in a way that also increases male fitness. This might occur because the reduction in residual reproductive value of the fema
Using R In Generalized Linear Models
Directory of Open Access Journals (Sweden)
Mihaela Covrig
2015-09-01
Full Text Available This paper aims to approach the estimation of generalized linear models (GLM on the basis of the glm routine package in R. Particularly, regression models will be analyzed for those cases in which the explained variable follows a Poisson or a Negative Binomial distribution. The paper will briefly present the GLM methodology for count data, while the practical part will revolve around estimating and comparing models in which the response variable shows the number of claims in a portfolio of automobile insurance policies.
2017-01-01
Background Experimental manipulations of floral nectar in food deceptive species can reveal insights into the evolutionary consequences of the deceptive strategy. When coupled to pollen tracking, the effects of the deceptive pollination syndrome on both male and female reproductive success may be quantified. Attraction of pollinators in deceit-pollinated species often relies on producing a conspicuous floral display which may increase visibility to pollinators, but in-turn may increase within plant selfing. Methodology To understand the role of deception in Orchidaceae reproduction we studied Cypripedium candidum. All species of the Cypripedium genus employ a generalized food deceptive pollination strategy and have been suggested as a model system for the study of pollinator deception. We conducted a nectar addition experiment that randomly assigned the four plants closest to a transect point to receive one of four histochemical dyes. Two individuals selected for nectar addition in each of altogether 25 blocks received 2μl of 25% sucrose solution in the labellum of each flower, while two others received no artificial nectar. Number of fruits produced, fruit mass and fruit abortion were scored at the end of the four-month experiment. Results Nectar addition increased (ppollen discounting by nearly 3x, while plants not receiving nectar had greater (ppollen discounting. There was a non-significant (p = 0.0645) trend for deceptive plants to set more fruit, while presence of nectar did not affect pollen export. Conclusions This study demonstrates the adaptive advantages of food deception by showing a concurrent reduction in particular male and female functions when a food reward is restored to a deceptive flower. We found generalized food deception to not only decrease inbreeding depression in the system, but concurrently have no effect on pollinator attraction and fruit set when compared with rewarding flowers. PMID:28141838
String Field Equations from Generalized Sigma Model
Energy Technology Data Exchange (ETDEWEB)
Bardakci, K.; Bernardo, L.M.
1997-01-29
We propose a new approach for deriving the string field equations from a general sigma model on the world-sheet. This approach leads to an equation which combines some of the attractive features of both the renormalization group method and the covariant beta function treatment of the massless excitations. It has the advantage of being covariant under a very general set of both local and non-local transformations in the field space. We apply it to the tachyon, massless and first massive level, and show that the resulting field equations reproduce the correct spectrum of a left-right symmetric closed bosonic string.
SCIPUFF - a generalized hazard dispersion model
Energy Technology Data Exchange (ETDEWEB)
Sykes, R.I.; Henn, D.S.; Parker, S.F.; Gabruk, R.S. [Titan Research and Technology, Princeton, NJ (United States)
1996-12-31
One of the more popular techniques for efficiently representing the dispersion process is the Gaussian puff model, which uses a collection of Lagrangian puffs with Gaussian concentration profiles. SCIPUFF (Second-order Closure Integrated Puff) is an advanced Gaussian puff model. SCIPUFF which uses second-order turbulence closure techniques to relate the dispersion rates to measurable turbulent velocity statistics, providing a wide range of applicability. In addition, the closure model provides a prediction of the statistical variance in the concentration field which can be used to estimate the uncertainty in the dispersion prediction resulting from the inherent uncertainty in the wind field. SCIPUFF has been greatly extended from a power plant plume model to describe more general source characteristics, material properties, and longer range dispersion. In addition, a Graphical User Interface has been developed to provide interactive problem definition and output display. This presentation describes the major features of the model, and presents several example calculations.
General regression and representation model for classification.
Directory of Open Access Journals (Sweden)
Jianjun Qian
Full Text Available Recently, the regularized coding-based classification methods (e.g. SRC and CRC show a great potential for pattern classification. However, most existing coding methods assume that the representation residuals are uncorrelated. In real-world applications, this assumption does not hold. In this paper, we take account of the correlations of the representation residuals and develop a general regression and representation model (GRR for classification. GRR not only has advantages of CRC, but also takes full use of the prior information (e.g. the correlations between representation residuals and representation coefficients and the specific information (weight matrix of image pixels to enhance the classification performance. GRR uses the generalized Tikhonov regularization and K Nearest Neighbors to learn the prior information from the training data. Meanwhile, the specific information is obtained by using an iterative algorithm to update the feature (or image pixel weights of the test sample. With the proposed model as a platform, we design two classifiers: basic general regression and representation classifier (B-GRR and robust general regression and representation classifier (R-GRR. The experimental results demonstrate the performance advantages of proposed methods over state-of-the-art algorithms.
Generalized Models for Rock Joint Surface Shapes
Directory of Open Access Journals (Sweden)
Shigui Du
2014-01-01
Full Text Available Generalized models of joint surface shapes are the foundation for mechanism studies on the mechanical effects of rock joint surface shapes. Based on extensive field investigations of rock joint surface shapes, generalized models for three level shapes named macroscopic outline, surface undulating shape, and microcosmic roughness were established through statistical analyses of 20,078 rock joint surface profiles. The relative amplitude of profile curves was used as a borderline for the division of different level shapes. The study results show that the macroscopic outline has three basic features such as planar, arc-shaped, and stepped; the surface undulating shape has three basic features such as planar, undulating, and stepped; and the microcosmic roughness has two basic features such as smooth and rough.
Higher Dimensional Generalizations of the SYK Model
Berkooz, Micha; Rozali, Moshe; Simón, Joan
2016-01-01
We discuss a 1+1 dimensional generalization of the Sachdev-Ye-Kitaev model. The model contains $N$ Majorana fermions at each lattice site with a nearest-neighbour hopping term. The SYK random interaction is restricted to low momentum fermions of definite chirality within each lattice site. This gives rise to an ordinary 1+1 field theory above some energy scale and a low energy SYK-like behavior. We exhibit a class of low-pass filters which give rise to a rich variety of hyperscaling behaviour in the IR. We also discuss another set of generalizations which describes probing an SYK system with an external fermion, together with the new scaling behavior they exhibit in the IR.
Generalized Penner models to all genera
Ambjørn, Jan; Kristjansen, C F
1994-01-01
We give a complete description of the genus expansion of the one-cut solution to the generalized Penner model. The solution is presented in a form which allows us in a very straightforward manner to localize critical points and to investigate the scaling behaviour of the model in the vicinity of these points. We carry out an analysis of the critical behaviour to all genera addressing all types of multi-critical points. In certain regions of the coupling constant space the model must be defined via analytical continuation. We show in detail how this works for the Penner model. Using analytical continuation it is possible to reach the fermionic 1-matrix model. We show that the critical points of the fermionic 1-matrix model can be indexed by an integer, $m$, as it was the case for the ordinary hermitian 1-matrix model. Furthermore the $m$'th multi-critical fermionic model has to all genera the same value of $\\gamma_{str}$ as the $m$'th multi-critical hermitian model. However, the coefficients of the topological...
Parallel Computing of Ocean General Circulation Model
Institute of Scientific and Technical Information of China (English)
无
2001-01-01
This paper discusses the parallel computing of the thirdgeneration Ocea n General Circulation Model (OGCM) from the State Key Laboratory of Numerical Mo deling for Atmospheric Science and Geophysical Fluid Dynamics(LASG),Institute of Atmosphere Physics(IAP). Meanwhile, several optimization strategies for paralle l computing of OGCM (POGCM) on Scalable Shared Memory Multiprocessor (S2MP) are presented. Using Message Passing Interface (MPI), we obtain super linear speedup on SGI Origin 2000 for parallel OGCM(POGCM) after optimization.
Modeling the pion Generalized Parton Distribution
Mezrag, C
2015-01-01
We compute the pion Generalized Parton Distribution (GPD) in a valence dressed quarks approach. We model the Mellin moments of the GPD using Ans\\"atze for Green functions inspired by the numerical solutions of the Dyson-Schwinger Equations (DSE) and the Bethe-Salpeter Equation (BSE). Then, the GPD is reconstructed from its Mellin moment using the Double Distribution (DD) formalism. The agreement with available experimental data is very good.
A General Business Model for Marine Reserves
Sala, Enric; Costello, Christopher; Dougherty, Dawn; Heal, Geoffrey; Kelleher, Kieran; Murray, Jason H.; Rosenberg, Andrew A.; Sumaila, Rashid
2013-01-01
Marine reserves are an effective tool for protecting biodiversity locally, with potential economic benefits including enhancement of local fisheries, increased tourism, and maintenance of ecosystem services. However, fishing communities often fear short-term income losses associated with closures, and thus may oppose marine reserves. Here we review empirical data and develop bioeconomic models to show that the value of marine reserves (enhanced adjacent fishing + tourism) may often exceed the pre-reserve value, and that economic benefits can offset the costs in as little as five years. These results suggest the need for a new business model for creating and managing reserves, which could pay for themselves and turn a profit for stakeholder groups. Our model could be expanded to include ecosystem services and other benefits, and it provides a general framework to estimate costs and benefits of reserves and to develop such business models. PMID:23573192
A general business model for marine reserves.
Directory of Open Access Journals (Sweden)
Enric Sala
Full Text Available Marine reserves are an effective tool for protecting biodiversity locally, with potential economic benefits including enhancement of local fisheries, increased tourism, and maintenance of ecosystem services. However, fishing communities often fear short-term income losses associated with closures, and thus may oppose marine reserves. Here we review empirical data and develop bioeconomic models to show that the value of marine reserves (enhanced adjacent fishing + tourism may often exceed the pre-reserve value, and that economic benefits can offset the costs in as little as five years. These results suggest the need for a new business model for creating and managing reserves, which could pay for themselves and turn a profit for stakeholder groups. Our model could be expanded to include ecosystem services and other benefits, and it provides a general framework to estimate costs and benefits of reserves and to develop such business models.
A general business model for marine reserves.
Sala, Enric; Costello, Christopher; Dougherty, Dawn; Heal, Geoffrey; Kelleher, Kieran; Murray, Jason H; Rosenberg, Andrew A; Sumaila, Rashid
2013-01-01
Marine reserves are an effective tool for protecting biodiversity locally, with potential economic benefits including enhancement of local fisheries, increased tourism, and maintenance of ecosystem services. However, fishing communities often fear short-term income losses associated with closures, and thus may oppose marine reserves. Here we review empirical data and develop bioeconomic models to show that the value of marine reserves (enhanced adjacent fishing + tourism) may often exceed the pre-reserve value, and that economic benefits can offset the costs in as little as five years. These results suggest the need for a new business model for creating and managing reserves, which could pay for themselves and turn a profit for stakeholder groups. Our model could be expanded to include ecosystem services and other benefits, and it provides a general framework to estimate costs and benefits of reserves and to develop such business models.
De Mello, Fernanda; Oliveira, Carlos A L; Ribeiro, Ricardo P; Resende, Emiko K; Povh, Jayme A; Fornari, Darci C; Barreto, Rogério V; McManus, Concepta; Streit, Danilo
2015-01-01
Was evaluated the pattern of growth among females and males of tambaqui by Gompertz nonlinear regression model. Five traits of economic importance were measured on 145 animals during the three years, totaling 981 morphometric data analyzed. Different curves were adjusted between males and females for body weight, height and head length and only one curve was adjusted to the width and body length. The asymptotic weight (a) and relative growth rate to maturity (k) were different between sexes in animals with ± 5 kg; slaughter weight practiced by a specific niche market, very profitable. However, there was no difference between males and females up to ± 2 kg; slaughter weight established to supply the bigger consumer market. Females showed weight greater than males (± 280 g), which are more suitable for fish farming purposes defined for the niche market to larger animals. In general, males had lower maximum growth rate (8.66 g / day) than females (9.34 g / day), however, reached faster than females, 476 and 486 days growth rate, respectively. The height and length body are the traits that contributed most to the weight at 516 days (P <0.001).
A proposed general model of information behaviour.
Directory of Open Access Journals (Sweden)
2003-01-01
Full Text Available Presents a critical description of Wilson's (1996 global model of information behaviour and proposes major modification on the basis of research into information behaviour of managers, conducted in Poland. The theoretical analysis and research results suggest that Wilson's model has certain imperfections, both in its conceptual content, and in graphical presentation. The model, for example, cannot be used to describe managers' information behaviour, since managers basically are not the end users of external from organization or computerized information services, and they acquire information mainly through various intermediaries. Therefore, the model cannot be considered as a general model, applicable to every category of information users. The proposed new model encompasses the main concepts of Wilson's model, such as: person-in-context, three categories of intervening variables (individual, social and environmental, activating mechanisms, cyclic character of information behaviours, and the adoption of a multidisciplinary approach to explain them. However, the new model introduces several changes. They include: 1. identification of 'context' with the intervening variables; 2. immersion of the chain of information behaviour in the 'context', to indicate that the context variables influence behaviour at all stages of the process (identification of needs, looking for information, processing and using it; 3. stress is put on the fact that the activating mechanisms also can occur at all stages of the information acquisition process; 4. introduction of two basic strategies of looking for information: personally and/or using various intermediaries.
Vitoratou, S; Ntzoufras, I; Theleritis, C; Smyrnis, N; Stefanis, N C
2015-06-01
In this work we consider Cloninger's psychobiological model, which measures two dimensions of personality: character and temperament. Temperament refers to the biological basis of personality and its characteristics, while character refers to an individual's attitudes towards own self, towards humanity and as part of the universe. The Temperament and Character Inventory-Revised-140 (TCI-R-140) was administered to 3 divergent samples: a general population sample, a sample of male conscripts and a sample of individuals attending a substance abuse rehabilitation programme. Score differences among the three samples were assessed controlling for age and gender and reliability coefficients are reported. The latent structure was studied in all samples, using exploratory and confirmatory factor analysis methods (EFA and CFA respectively). The proposed structure was partially replicated via EFA. CFA however indicated less than satisfactory fit, as in previously reported results. To improve the fit, the path diagram was augmented to account for multiple factor complexity, as suggested by the EFA results in all samples. While retaining the original seven-factor structure, the augmented model provided adequate fit. The consistency of the inventory was satisfactory in all samples. Evidence for the construct validity was found in relation to aggression. This is the first study to conclude in adequate fit, after allowing for the indicators to load on more than one factor within each dimension. While cross-national differences apply, our results were similar (when comparable) with previously reported ones in the literature. Copyright © 2015 Elsevier Masson SAS. All rights reserved.
Generalized model of brushless dc generator
Vadher, V. V.; Kettleborough, J. Gordon; Smith, I. R.; Gerges, Wahid R.
1989-07-01
A generalized model is described for a brushless dc machine consisting of a multiphase synchronous machine with a full-wave bridge rectifier connected to its output terminals. The state-variable equations for the machine are suitable for numerical integration on a digital computer, and are assembled in a form which permits investigations to be made on the effects of different numbers of armature phase windings and different winding connections. The model has been used in both steady-state and transient studies on a number of generating units, with the detailed information which is provided being beneficial to design engineers. Comparisons presented between predicted and measured results illustrate the validity of the model and the mathematical techniques adopted, and confirm that accurate information on the performance of a brushless generator may be obtained prior to manufacture.
Gravitational Interactions in a General Multibrane Model
Bloomfield, Jolyon K
2010-01-01
The gravitational interactions of the four-dimensional effective theory describing a general N-brane model in five dimensions without radion stabilization are analyzed. The parameter space is constrained by requiring that there be no ghost modes in the theory, and that the Eddington parameterized post-Newtonian parameter gamma be consistent with observations. We show that we must reside on the brane on which the warp factor is maximized. The resultant theory contains N-1 radion modes in a nonlinear sigma model, with the target space being a subset of hyperbolic space. Imposing observational constraints on the relative strengths of gravitational interactions of dark and visible matter shows that at least 99.8% of the dark matter must live on our brane in this model.
A generalized additive regression model for survival times
DEFF Research Database (Denmark)
Scheike, Thomas H.
2001-01-01
Additive Aalen model; counting process; disability model; illness-death model; generalized additive models; multiple time-scales; non-parametric estimation; survival data; varying-coefficient models......Additive Aalen model; counting process; disability model; illness-death model; generalized additive models; multiple time-scales; non-parametric estimation; survival data; varying-coefficient models...
A generalized additive regression model for survival times
DEFF Research Database (Denmark)
Scheike, Thomas H.
2001-01-01
Additive Aalen model; counting process; disability model; illness-death model; generalized additive models; multiple time-scales; non-parametric estimation; survival data; varying-coefficient models......Additive Aalen model; counting process; disability model; illness-death model; generalized additive models; multiple time-scales; non-parametric estimation; survival data; varying-coefficient models...
Elizur, Y; Ziv, M
2001-01-01
While heterosexist family undermining has been demonstrated to be a developmental risk factor in the life of persons with same-gender orientation, the issue of protective family factors is both controversial and relatively neglected. In this study of Israeli gay males (N = 114), we focused on the interrelations of family support, family acceptance and family knowledge of gay orientation, and gay male identity formation, and their effects on mental health and self-esteem. A path model was proposed based on the hypotheses that family support, family acceptance, family knowledge, and gay identity formation have an impact on psychological adjustment, and that family support has an effect on gay identity formation that is mediated by family acceptance. The assessment of gay identity formation was based on an established stage model that was streamlined for cross-cultural practice by defining three basic processes of same-gender identity formation: self-definition, self-acceptance, and disclosure (Elizur & Mintzer, 2001). The testing of our conceptual path model demonstrated an excellent fit with the data. An alternative model that hypothesized effects of gay male identity on family acceptance and family knowledge did not fit the data. Interpreting these results, we propose that the main effect of family support/acceptance on gay identity is related to the process of disclosure, and that both general family support and family acceptance of same-gender orientation play a significant role in the psychological adjustment of gay men.
Modelling debris flows down general channels
Directory of Open Access Journals (Sweden)
S. P. Pudasaini
2005-01-01
Full Text Available This paper is an extension of the single-phase cohesionless dry granular avalanche model over curved and twisted channels proposed by Pudasaini and Hutter (2003. It is a generalisation of the Savage and Hutter (1989, 1991 equations based on simple channel topography to a two-phase fluid-solid mixture of debris material. Important terms emerging from the correct treatment of the kinematic and dynamic boundary condition, and the variable basal topography are systematically taken into account. For vanishing fluid contribution and torsion-free channel topography our new model equations exactly degenerate to the previous Savage-Hutter model equations while such a degeneration was not possible by the Iverson and Denlinger (2001 model, which, in fact, also aimed to extend the Savage and Hutter model. The model equations of this paper have been rigorously derived; they include the effects of the curvature and torsion of the topography, generally for arbitrarily curved and twisted channels of variable channel width. The equations are put into a standard conservative form of partial differential equations. From these one can easily infer the importance and influence of the pore-fluid-pressure distribution in debris flow dynamics. The solid-phase is modelled by applying a Coulomb dry friction law whereas the fluid phase is assumed to be an incompressible Newtonian fluid. Input parameters of the equations are the internal and bed friction angles of the solid particles, the viscosity and volume fraction of the fluid, the total mixture density and the pore pressure distribution of the fluid at the bed. Given the bed topography and initial geometry and the initial velocity profile of the debris mixture, the model equations are able to describe the dynamics of the depth profile and bed parallel depth-averaged velocity distribution from the initial position to the final deposit. A shock capturing, total variation diminishing numerical scheme is implemented to
A generalized model for compact stars
Energy Technology Data Exchange (ETDEWEB)
Aziz, Abdul [Bodai High School (H.S.), Department of Physics, Kolkata, West Bengal (India); Ray, Saibal [Government College of Engineering and Ceramic Technology, Department of Physics, Kolkata, West Bengal (India); Rahaman, Farook [Jadavpur University, Department of Mathematics, Kolkata, West Bengal (India)
2016-05-15
By virtue of the maximum entropy principle, we get an Euler-Lagrange equation which is a highly nonlinear differential equation containing the mass function and its derivatives. Solving the equation by a homotopy perturbation method we derive a generalized expression for the mass which is a polynomial function of the radial distance. Using the mass function we find a partially stable configuration and its characteristics. We show that different physical features of the known compact stars, viz. Her X-1, RX J 1856-37, SAX J (SS1), SAX J (SS2), and PSR J 1614-2230, can be explained by the present model. (orig.)
Testing Parametric versus Semiparametric Modelling in Generalized Linear Models
Härdle, W.K.; Mammen, E.; Müller, M.D.
1996-01-01
We consider a generalized partially linear model E(Y|X,T) = G{X'b + m(T)} where G is a known function, b is an unknown parameter vector, and m is an unknown function.The paper introduces a test statistic which allows to decide between a parametric and a semiparametric model: (i) m is linear, i.e. m(
The General Linear Model as Structural Equation Modeling
Graham, James M.
2008-01-01
Statistical procedures based on the general linear model (GLM) share much in common with one another, both conceptually and practically. The use of structural equation modeling path diagrams as tools for teaching the GLM as a body of connected statistical procedures is presented. A heuristic data set is used to demonstrate a variety of univariate…
Snow hydrology in a general circulation model
Marshall, Susan; Roads, John O.; Glatzmaier, Gary
1994-01-01
A snow hydrology has been implemented in an atmospheric general circulation model (GCM). The snow hydrology consists of parameterizations of snowfall and snow cover fraction, a prognostic calculation of snow temperature, and a model of the snow mass and hydrologic budgets. Previously, only snow albedo had been included by a specified snow line. A 3-year GCM simulation with this now more complete surface hydrology is compared to a previous GCM control run with the specified snow line, as well as with observations. In particular, the authors discuss comparisons of the atmospheric and surface hydrologic budgets and the surface energy budget for U.S. and Canadian areas. The new snow hydrology changes the annual cycle of the surface moisture and energy budgets in the model. There is a noticeable shift in the runoff maximum from winter in the control run to spring in the snow hydrology run. A substantial amount of GCM winter precipitation is now stored in the seasonal snowpack. Snow cover also acts as an important insulating layer between the atmosphere and the ground. Wintertime soil temperatures are much higher in the snow hydrology experiment than in the control experiment. Seasonal snow cover is important for dampening large fluctuations in GCM continental skin temperature during the Northern Hemisphere winter. Snow depths and snow extent show good agreement with observations over North America. The geographic distribution of maximum depths is not as well simulated by the model due, in part, to the coarse resolution of the model. The patterns of runoff are qualitatively and quantitatively similar to observed patterns of streamflow averaged over the continental United States. The seasonal cycles of precipitation and evaporation are also reasonably well simulated by the model, although their magnitudes are larger than is observed. This is due, in part, to a cold bias in this model, which results in a dry model atmosphere and enhances the hydrologic cycle everywhere.
The epistemological status of general circulation models
Loehle, Craig
2017-05-01
Forecasts of both likely anthropogenic effects on climate and consequent effects on nature and society are based on large, complex software tools called general circulation models (GCMs). Forecasts generated by GCMs have been used extensively in policy decisions related to climate change. However, the relation between underlying physical theories and results produced by GCMs is unclear. In the case of GCMs, many discretizations and approximations are made, and simulating Earth system processes is far from simple and currently leads to some results with unknown energy balance implications. Statistical testing of GCM forecasts for degree of agreement with data would facilitate assessment of fitness for use. If model results need to be put on an anomaly basis due to model bias, then both visual and quantitative measures of model fit depend strongly on the reference period used for normalization, making testing problematic. Epistemology is here applied to problems of statistical inference during testing, the relationship between the underlying physics and the models, the epistemic meaning of ensemble statistics, problems of spatial and temporal scale, the existence or not of an unforced null for climate fluctuations, the meaning of existing uncertainty estimates, and other issues. Rigorous reasoning entails carefully quantifying levels of uncertainty.
General linear matrix model, Minkowski spacetime and the Standard Model
Belyea, Chris
2010-01-01
The Hermitian matrix model with general linear symmetry is argued to decouple into a finite unitary matrix model that contains metastable multidimensional lattice configurations and a fermion determinant. The simplest metastable state is a Hermitian Weyl kinetic operator of either handedness on a 3+1 D lattice with general nonlocal interactions. The Hermiticity produces 16 effective Weyl fermions by species doubling, 8 left- and 8 right-handed. These are identified with a Standard Model generation. Only local non-anomalous gauge fields within the soup of general fluctuations can survive at long distances, and the degrees of freedom for gauge fields of an $SU(8)_L X SU(8)_R$ GUT are present. Standard Model gauge symmetries associate with particular species symmetries, for example change of QCD color associates with permutation of doubling status amongst space directions. Vierbein gravity is probably also generated. While fundamental Higgs fields are not possible, low fermion current masses can arise from chira...
Walsh, Ryan P; Michaels, Helen J
2017-01-01
Experimental manipulations of floral nectar in food deceptive species can reveal insights into the evolutionary consequences of the deceptive strategy. When coupled to pollen tracking, the effects of the deceptive pollination syndrome on both male and female reproductive success may be quantified. Attraction of pollinators in deceit-pollinated species often relies on producing a conspicuous floral display which may increase visibility to pollinators, but in-turn may increase within plant selfing. To understand the role of deception in Orchidaceae reproduction we studied Cypripedium candidum. All species of the Cypripedium genus employ a generalized food deceptive pollination strategy and have been suggested as a model system for the study of pollinator deception. We conducted a nectar addition experiment that randomly assigned the four plants closest to a transect point to receive one of four histochemical dyes. Two individuals selected for nectar addition in each of altogether 25 blocks received 2μl of 25% sucrose solution in the labellum of each flower, while two others received no artificial nectar. Number of fruits produced, fruit mass and fruit abortion were scored at the end of the four-month experiment. Nectar addition increased (pattraction and fruit set when compared with rewarding flowers.
Modeling Manhood: Reimagining Black Male Identities in School
Givens, Jarvis R.; Nasir, Na'ilah; ross, kihana; de Royston, Maxine McKinney
2016-01-01
This paper examines the process by which stereotypical mainstream representations of black males (as hard, as anti-school, and as disconnected from the domestic sphere) were reimagined in all-black, all-male manhood development classes for 9th graders in urban public high schools. Findings show that instructors debunked stereotypes and created new…
Multipath diffusion: A general numerical model
Lee, J. K. W.; Aldama, A. A.
1992-06-01
The effect of high-diffusivity pathways on bulk diffusion of a solute in a material has been modeled previously for simple geometries such as those in tracer diffusion experiments, but not for the geometries and boundary conditions appropriate for experiments involving bulk exchange. Using a coupled system of equations for simultaneous diffusion of a solute through two families of diffusion pathways with differing diffusivities, a general 1-D finite difference model written in FORTRAN has been developed which can be used to examine the effect of high-diffusivity paths on partial and total concentration profiles within a homogeneous isotropic sphere, infinite cylinder, and infinite slab. The partial differential equations are discretized using the θ-method/central-difference scheme, and an iterative procedure analogous to the Gauss-Seidel method is employed to solve the two systems of coupled equations. Using Fourier convergence analysis, the procedure is shown to be unconditionally convergent. Computer simulations demonstrate that a multipath diffusion mechanism can enhance significantly the bulk diffusivity of a diffusing solute species through a material. The amount of solute escaping from a material is dependent strongly on the exchange coefficients, which govern the transfer of solute from the crystal lattice to the high-diffusivity paths and vice versa. In addition, the exchange coefficients ( ϰ1, and ϰ2) seem to control not only the amount of solute that is lost, but also the shape of the concentration profile. If | K1| < | K2|, concentration profiles generally are non-Fickian in shape, typically having shallow concentration gradients near the center (radius r = 0) and steep gradients towards the outer boundary of the material ( r = R). When | K1| ⩾ | K2| a concentration profile is generated which resembles a Fickian (volume) diffusion profile with an apparent bulk diffusivity between that of the crystal lattice and that of the high-diffusivity pathways
A Simple General Model of Evolutionary Dynamics
Thurner, Stefan
Evolution is a process in which some variations that emerge within a population (of, e.g., biological species or industrial goods) get selected, survive, and proliferate, whereas others vanish. Survival probability, proliferation, or production rates are associated with the "fitness" of a particular variation. We argue that the notion of fitness is an a posteriori concept in the sense that one can assign higher fitness to species or goods that survive but one can generally not derive or predict fitness per se. Whereas proliferation rates can be measured, fitness landscapes, that is, the inter-dependence of proliferation rates, cannot. For this reason we think that in a physical theory of evolution such notions should be avoided. Here we review a recent quantitative formulation of evolutionary dynamics that provides a framework for the co-evolution of species and their fitness landscapes (Thurner et al., 2010, Physica A 389, 747; Thurner et al., 2010, New J. Phys. 12, 075029; Klimek et al., 2009, Phys. Rev. E 82, 011901 (2010). The corresponding model leads to a generic evolutionary dynamics characterized by phases of relative stability in terms of diversity, followed by phases of massive restructuring. These dynamical modes can be interpreted as punctuated equilibria in biology, or Schumpeterian business cycles (Schumpeter, 1939, Business Cycles, McGraw-Hill, London) in economics. We show that phase transitions that separate phases of high and low diversity can be approximated surprisingly well by mean-field methods. We demonstrate that the mathematical framework is suited to understand systemic properties of evolutionary systems, such as their proneness to collapse, or their potential for diversification. The framework suggests that evolutionary processes are naturally linked to self-organized criticality and to properties of production matrices, such as their eigenvalue spectra. Even though the model is phrased in general terms it is also practical in the sense
Functional methods in the generalized Dicke model
Energy Technology Data Exchange (ETDEWEB)
Alcalde, M. Aparicio; Lemos, A.L.L. de; Svaiter, N.F. [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil)]. E-mails: aparicio@cbpf.br; aluis@cbpf.br; nfuxsvai@cbpf.br
2007-07-01
The Dicke model describes an ensemble of N identical two-level atoms (qubits) coupled to a single quantized mode of a bosonic field. The fermion Dicke model should be obtained by changing the atomic pseudo-spin operators by a linear combination of Fermi operators. The generalized fermion Dicke model is defined introducing different coupling constants between the single mode of the bosonic field and the reservoir, g{sub 1} and g{sub 2} for rotating and counter-rotating terms respectively. In the limit N -> {infinity}, the thermodynamic of the fermion Dicke model can be analyzed using the path integral approach with functional method. The system exhibits a second order phase transition from normal to superradiance at some critical temperature with the presence of a condensate. We evaluate the critical transition temperature and present the spectrum of the collective bosonic excitations for the general case (g{sub 1} {ne} 0 and g{sub 2} {ne} 0). There is quantum critical behavior when the coupling constants g{sub 1} and g{sub 2} satisfy g{sub 1} + g{sub 2}=({omega}{sub 0} {omega}){sup 1/2}, where {omega}{sub 0} is the frequency of the mode of the field and {omega} is the energy gap between energy eigenstates of the qubits. Two particular situations are analyzed. First, we present the spectrum of the collective bosonic excitations, in the case g{sub 1} {ne} 0 and g{sub 2} {ne} 0, recovering the well known results. Second, the case g{sub 1} {ne} 0 and g{sub 2} {ne} 0 is studied. In this last case, it is possible to have a super radiant phase when only virtual processes are introduced in the interaction Hamiltonian. Here also appears a quantum phase transition at the critical coupling g{sub 2} ({omega}{sub 0} {omega}){sup 1/2}, and for larger values for the critical coupling, the system enter in this super radiant phase with a Goldstone mode. (author)
Thurstonian models for sensory discrimination tests as generalized linear models
DEFF Research Database (Denmark)
Brockhoff, Per B.; Christensen, Rune Haubo Bojesen
2010-01-01
Sensory discrimination tests such as the triangle, duo-trio, 2-AFC and 3-AFC tests produce binary data and the Thurstonian decision rule links the underlying sensory difference 6 to the observed number of correct responses. In this paper it is shown how each of these four situations can be viewed...... as a so-called generalized linear model. The underlying sensory difference 6 becomes directly a parameter of the statistical model and the estimate d' and it's standard error becomes the "usual" output of the statistical analysis. The d' for the monadic A-NOT A method is shown to appear as a standard...... linear contrast in a generalized linear model using the probit link function. All methods developed in the paper are implemented in our free R-package sensR (http://www.cran.r-project.org/package=sensR/). This includes the basic power and sample size calculations for these four discrimination tests...
Rudy, Ashley C. A.; Lamoureux, Scott F.; Treitz, Paul; van Ewijk, Karin Y.
2016-07-01
To effectively assess and mitigate risk of permafrost disturbance, disturbance-prone areas can be predicted through the application of susceptibility models. In this study we developed regional susceptibility models for permafrost disturbances using a field disturbance inventory to test the transferability of the model to a broader region in the Canadian High Arctic. Resulting maps of susceptibility were then used to explore the effect of terrain variables on the occurrence of disturbances within this region. To account for a large range of landscape characteristics, the model was calibrated using two locations: Sabine Peninsula, Melville Island, NU, and Fosheim Peninsula, Ellesmere Island, NU. Spatial patterns of disturbance were predicted with a generalized linear model (GLM) and generalized additive model (GAM), each calibrated using disturbed and randomized undisturbed locations from both locations and GIS-derived terrain predictor variables including slope, potential incoming solar radiation, wetness index, topographic position index, elevation, and distance to water. Each model was validated for the Sabine and Fosheim Peninsulas using independent data sets while the transferability of the model to an independent site was assessed at Cape Bounty, Melville Island, NU. The regional GLM and GAM validated well for both calibration sites (Sabine and Fosheim) with the area under the receiver operating curves (AUROC) > 0.79. Both models were applied directly to Cape Bounty without calibration and validated equally with AUROC's of 0.76; however, each model predicted disturbed and undisturbed samples differently. Additionally, the sensitivity of the transferred model was assessed using data sets with different sample sizes. Results indicated that models based on larger sample sizes transferred more consistently and captured the variability within the terrain attributes in the respective study areas. Terrain attributes associated with the initiation of disturbances were
An integral projection model with YY-males and application to evaluating grass carp control
Erickson, Richard A.; Eager, Eric A.; Brey, Marybeth; Hansen, Michael J.; Kocovsky, Patrick
2017-01-01
Invasive fish species disrupt ecosystems and cause economic damage. Several methods have been discussed to control populations of invasive fish including the release of YY-males. YY-males are fish that have 2 male chromosomes compared to a XY-male. When YY-males mate, they only produce male (XY) offspring. This decreases the female proportion of the population and can, in theory, eradicate local populations by biasing the sex-ratio. YY-males have been used as a population control tool for brook trout in montane streams and lakes in Idaho, USA. The YY-male control method has been discussed for grass carp in Lake Erie, North America. We developed and presented an integral projection model for grass carp to model the use of YY-males as a control method for populations in this lake. Using only the YY-male control method, we found that high levels of YY-males would need to be release annually to control the species. Specifically, these levels were the same order of magnitude as the baseline adult population (e.g., 1000 YY-males needed to be released annual for 20 years to control a baseline adult population of 2500 grass carp). These levels may not be reasonable or obtainable for fisheries managers given the impacts of YY-males on aquatic vegetation and other constraints of natural resource management.
Bayesian Subset Modeling for High-Dimensional Generalized Linear Models
Liang, Faming
2013-06-01
This article presents a new prior setting for high-dimensional generalized linear models, which leads to a Bayesian subset regression (BSR) with the maximum a posteriori model approximately equivalent to the minimum extended Bayesian information criterion model. The consistency of the resulting posterior is established under mild conditions. Further, a variable screening procedure is proposed based on the marginal inclusion probability, which shares the same properties of sure screening and consistency with the existing sure independence screening (SIS) and iterative sure independence screening (ISIS) procedures. However, since the proposed procedure makes use of joint information from all predictors, it generally outperforms SIS and ISIS in real applications. This article also makes extensive comparisons of BSR with the popular penalized likelihood methods, including Lasso, elastic net, SIS, and ISIS. The numerical results indicate that BSR can generally outperform the penalized likelihood methods. The models selected by BSR tend to be sparser and, more importantly, of higher prediction ability. In addition, the performance of the penalized likelihood methods tends to deteriorate as the number of predictors increases, while this is not significant for BSR. Supplementary materials for this article are available online. © 2013 American Statistical Association.
Climatology of the HOPE-G global ocean general circulation model - Sea ice general circulation model
Energy Technology Data Exchange (ETDEWEB)
Legutke, S. [Deutsches Klimarechenzentrum (DKRZ), Hamburg (Germany); Maier-Reimer, E. [Max-Planck-Institut fuer Meteorologie, Hamburg (Germany)
1999-12-01
The HOPE-G global ocean general circulation model (OGCM) climatology, obtained in a long-term forced integration is described. HOPE-G is a primitive-equation z-level ocean model which contains a dynamic-thermodynamic sea-ice model. It is formulated on a 2.8 grid with increased resolution in low latitudes in order to better resolve equatorial dynamics. The vertical resolution is 20 layers. The purpose of the integration was both to investigate the models ability to reproduce the observed general circulation of the world ocean and to obtain an initial state for coupled atmosphere - ocean - sea-ice climate simulations. The model was driven with daily mean data of a 15-year integration of the atmosphere general circulation model ECHAM4, the atmospheric component in later coupled runs. Thereby, a maximum of the flux variability that is expected to appear in coupled simulations is included already in the ocean spin-up experiment described here. The model was run for more than 2000 years until a quasi-steady state was achieved. It reproduces the major current systems and the main features of the so-called conveyor belt circulation. The observed distribution of water masses is reproduced reasonably well, although with a saline bias in the intermediate water masses and a warm bias in the deep and bottom water of the Atlantic and Indian Oceans. The model underestimates the meridional transport of heat in the Atlantic Ocean. The simulated heat transport in the other basins, though, is in good agreement with observations. (orig.)
Climatology of the HOPE-G global ocean general circulation model - Sea ice general circulation model
Energy Technology Data Exchange (ETDEWEB)
Legutke, S. [Deutsches Klimarechenzentrum (DKRZ), Hamburg (Germany); Maier-Reimer, E. [Max-Planck-Institut fuer Meteorologie, Hamburg (Germany)
1999-12-01
The HOPE-G global ocean general circulation model (OGCM) climatology, obtained in a long-term forced integration is described. HOPE-G is a primitive-equation z-level ocean model which contains a dynamic-thermodynamic sea-ice model. It is formulated on a 2.8 grid with increased resolution in low latitudes in order to better resolve equatorial dynamics. The vertical resolution is 20 layers. The purpose of the integration was both to investigate the models ability to reproduce the observed general circulation of the world ocean and to obtain an initial state for coupled atmosphere - ocean - sea-ice climate simulations. The model was driven with daily mean data of a 15-year integration of the atmosphere general circulation model ECHAM4, the atmospheric component in later coupled runs. Thereby, a maximum of the flux variability that is expected to appear in coupled simulations is included already in the ocean spin-up experiment described here. The model was run for more than 2000 years until a quasi-steady state was achieved. It reproduces the major current systems and the main features of the so-called conveyor belt circulation. The observed distribution of water masses is reproduced reasonably well, although with a saline bias in the intermediate water masses and a warm bias in the deep and bottom water of the Atlantic and Indian Oceans. The model underestimates the meridional transport of heat in the Atlantic Ocean. The simulated heat transport in the other basins, though, is in good agreement with observations. (orig.)
Appropriate model selection methods for nonstationary generalized extreme value models
Kim, Hanbeen; Kim, Sooyoung; Shin, Hongjoon; Heo, Jun-Haeng
2017-04-01
Several evidences of hydrologic data series being nonstationary in nature have been found to date. This has resulted in the conduct of many studies in the area of nonstationary frequency analysis. Nonstationary probability distribution models involve parameters that vary over time. Therefore, it is not a straightforward process to apply conventional goodness-of-fit tests to the selection of an appropriate nonstationary probability distribution model. Tests that are generally recommended for such a selection include the Akaike's information criterion (AIC), corrected Akaike's information criterion (AICc), Bayesian information criterion (BIC), and likelihood ratio test (LRT). In this study, the Monte Carlo simulation was performed to compare the performances of these four tests, with regard to nonstationary as well as stationary generalized extreme value (GEV) distributions. Proper model selection ratios and sample sizes were taken into account to evaluate the performances of all the four tests. The BIC demonstrated the best performance with regard to stationary GEV models. In case of nonstationary GEV models, the AIC proved to be better than the other three methods, when relatively small sample sizes were considered. With larger sample sizes, the AIC, BIC, and LRT presented the best performances for GEV models which have nonstationary location and/or scale parameters, respectively. Simulation results were then evaluated by applying all four tests to annual maximum rainfall data of selected sites, as observed by the Korea Meteorological Administration.
Directory of Open Access Journals (Sweden)
Windischberger Christian
2009-08-01
Full Text Available Abstract Background The ability to recognize emotions in facial expressions relies on an extensive neural network with the amygdala as the key node as has typically been demonstrated for the processing of fearful stimuli. A sufficient characterization of the factors influencing and modulating amygdala function, however, has not been reached now. Due to lacking or diverging results on its involvement in recognizing all or only certain negative emotions, the influence of gender or ethnicity is still under debate. This high-resolution fMRI study addresses some of the relevant parameters, such as emotional valence, gender and poser ethnicity on amygdala activation during facial emotion recognition in 50 Caucasian subjects. Stimuli were color photographs of emotional Caucasian and African American faces. Results Bilateral amygdala activation was obtained to all emotional expressions (anger, disgust, fear, happy, and sad and neutral faces across all subjects. However, only in males a significant correlation of amygdala activation and behavioral response to fearful stimuli was observed, indicating higher amygdala responses with better fear recognition, thus pointing to subtle gender differences. No significant influence of poser ethnicity on amygdala activation occurred, but analysis of recognition accuracy revealed a significant impact of poser ethnicity that was emotion-dependent. Conclusion Applying high-resolution fMRI while subjects were performing an explicit emotion recognition task revealed bilateral amygdala activation to all emotions presented and neutral expressions. This mechanism seems to operate similarly in healthy females and males and for both in-group and out-group ethnicities. Our results support the assumption that an intact amygdala response is fundamental in the processing of these salient stimuli due to its relevance detecting function.
Application of Improved Radiation Modeling to General Circulation Models
Energy Technology Data Exchange (ETDEWEB)
Michael J Iacono
2011-04-07
This research has accomplished its primary objectives of developing accurate and efficient radiation codes, validating them with measurements and higher resolution models, and providing these advancements to the global modeling community to enhance the treatment of cloud and radiative processes in weather and climate prediction models. A critical component of this research has been the development of the longwave and shortwave broadband radiative transfer code for general circulation model (GCM) applications, RRTMG, which is based on the single-column reference code, RRTM, also developed at AER. RRTMG is a rigorously tested radiation model that retains a considerable level of accuracy relative to higher resolution models and measurements despite the performance enhancements that have made it possible to apply this radiation code successfully to global dynamical models. This model includes the radiative effects of all significant atmospheric gases, and it treats the absorption and scattering from liquid and ice clouds and aerosols. RRTMG also includes a statistical technique for representing small-scale cloud variability, such as cloud fraction and the vertical overlap of clouds, which has been shown to improve cloud radiative forcing in global models. This development approach has provided a direct link from observations to the enhanced radiative transfer provided by RRTMG for application to GCMs. Recent comparison of existing climate model radiation codes with high resolution models has documented the improved radiative forcing capability provided by RRTMG, especially at the surface, relative to other GCM radiation models. Due to its high accuracy, its connection to observations, and its computational efficiency, RRTMG has been implemented operationally in many national and international dynamical models to provide validated radiative transfer for improving weather forecasts and enhancing the prediction of global climate change.
A Note on the Identifiability of Generalized Linear Mixed Models
DEFF Research Database (Denmark)
Labouriau, Rodrigo
2014-01-01
I present here a simple proof that, under general regularity conditions, the standard parametrization of generalized linear mixed model is identifiable. The proof is based on the assumptions of generalized linear mixed models on the first and second order moments and some general mild regularity ...... conditions, and, therefore, is extensible to quasi-likelihood based generalized linear models. In particular, binomial and Poisson mixed models with dispersion parameter are identifiable when equipped with the standard parametrization......I present here a simple proof that, under general regularity conditions, the standard parametrization of generalized linear mixed model is identifiable. The proof is based on the assumptions of generalized linear mixed models on the first and second order moments and some general mild regularity...
The Gender-Linked Language Effect: An Empirical Test of a General Process Model
Mulac, Anthony; Giles, Howard; Bradac, James J.; Palomares, Nicholas A.
2013-01-01
The gender-linked language effect (GLLE) is a phenomenon in which transcripts of female communicators are rated higher on Socio-Intellectual Status and Aesthetic Quality and male communicators are rated higher on Dynamism. This study proposed and tested a new general process model explanation for the GLLE, a central mediating element of which…
Psychopharmacology of male rat sexual behavior: modeling human sexual dysfunctions?
Olivier, B.; Chan, J.S.; Pattij, T.; Jong, T.R. de; Oosting, R.S.; Veening, J.G.; Waldinger, M.D.
2006-01-01
Most of our current understanding of the neurobiology, neuroanatomy and psychopharmacology of sexual behavior and ejaculatory function has been derived from preclinical studies in the rat. When a large population of male rats is tested on sexual activity during a number of successive tests, over tim
PEMAHAMAN DASAR ANALISIS MODEL COMPUTABLE GENERAL EQUILIBRIUM (CGE
Directory of Open Access Journals (Sweden)
Mardiyah Hayati
2013-11-01
Full Text Available Simple paper about basic understanding of computable general equilibrium aimed to give basic understanding about CGE. It consist of history of CGE, assumption of CGE model, excess and lack of CGE model, and creation of simple CGE model for closed economy. CGE model is suitable to be used for seeing impact of new policy implementation. It is because CGE model use general equilibrium in which this theory of general equilibrium explaining about inter-relation among markets in the economy system. CGE model was introduced in 1960s known as Johansen model. Next, it is expanded into various models such as: ORANI Model, General Trade Analysis Project (GTAP Model, and Applied General Equilibrium (AGE Model. In Indonesia, there are CGE ORANI Model, Wayang, Indonesia-E3 and IRCGE. CGE Model is created by assumption of perfect competition. Consumer maximizes utility, producer maximizes profit, and company maximizes zero profit condition.
Ota, Kazutaka; Kohda, Masanori; Hori, Michio; Sato, Tetsu
2011-10-01
Alternative reproductive tactics are widespread in males and may cause intraspecific differences in testes investment. Parker's sneak-guard model predicts that sneaker males, who mate under sperm competition risk, invest in testes relatively more than bourgeois conspecifics that have lower risk. Given that sneakers are much smaller than bourgeois males, sneakers may increase testes investment to overcome their limited sperm productivity because of their small body sizes. In this study, we examined the mechanism that mediates differential testes investment across tactics in the Lake Tanganyika cichlid fish Lamprologus callipterus. In the Rumonge population of Burundi, bourgeois males are small compared with those in other populations and have a body size close to sneaky dwarf males. Therefore, if differences in relative testis investment depend on sperm competition, the rank order of relative testis investment should be dwarf males > bourgeois males in Rumonge = bourgeois males in the other populations. If differences in relative testis investment depend on body size, the rank order of relative testes investment should be dwarf males > bourgeois males in Rumonge > bourgeois males in the other populations. Comparisons of relative testis investment among the three male groups supported the role of sperm competition, as predicted by the sneak-guard model. Nevertheless, the effects of absolute body size on testes investment should be considered to understand the mechanisms underlying intraspecific variation in testes investment caused by alternative reproductive tactics.
Multivariate statistical modelling based on generalized linear models
Fahrmeir, Ludwig
1994-01-01
This book is concerned with the use of generalized linear models for univariate and multivariate regression analysis. Its emphasis is to provide a detailed introductory survey of the subject based on the analysis of real data drawn from a variety of subjects including the biological sciences, economics, and the social sciences. Where possible, technical details and proofs are deferred to an appendix in order to provide an accessible account for non-experts. Topics covered include: models for multi-categorical responses, model checking, time series and longitudinal data, random effects models, and state-space models. Throughout, the authors have taken great pains to discuss the underlying theoretical ideas in ways that relate well to the data at hand. As a result, numerous researchers whose work relies on the use of these models will find this an invaluable account to have on their desks. "The basic aim of the authors is to bring together and review a large part of recent advances in statistical modelling of m...
Directory of Open Access Journals (Sweden)
Luis M. Afonso
2016-12-01
Full Text Available Negative pressure pulmonary oedema is a rare but potentially harmful event[1,3]. The mechanisms of this pulmonary injury are not totally understood. It is believed that airway obstruction, as caused by laryngospasm after extubation, combined with the attempt of a forced inspiring effort, produce a negative intrathoracic pressure, increasing the venous return with a consequent rise of the hydrostatic pressure, ultimately leading to a leakage of fluid to the extracellular compartment. Nevertheless, it is possible that other factors may contribute to this condition, including hypoxia, cardiogenic and neurogenic mechanisms[2]. We present the case of a healthy 20-years-old male, who underwent a deferred left clavicle osteosynthesis. Immediately after surgery, the patient developed irritative cough and marked dyspnoea. There were no auscultatory anomalies and the plain chest radiograph was normal. He did not show clinical improvement after increasing oxygen supply and bronchodilators, and was then transferred to our hospital for further evaluation. A thoracic Computed Tomography (CT scan was performed (figure 1, revealing multiple areas of ground glass aspect and alveolar filling with centrilobular distribution, suggesting alveolar haemorrhage. The patient remained under observation for 48 hours, with clear signs of clinical improvement and no further complications, with no need for positive pressure ventilation. He was discharged being asymptomatic and with no signs of respiratory distress, after a control CT scan showing radiologic improvement. This case highlights the need to be aware of this diagnosis, that is usually self-limited but can be life-threatening and require specific treatment.
Modeling local item dependence with the hierarchical generalized linear model.
Jiao, Hong; Wang, Shudong; Kamata, Akihito
2005-01-01
Local item dependence (LID) can emerge when the test items are nested within common stimuli or item groups. This study proposes a three-level hierarchical generalized linear model (HGLM) to model LID when LID is due to such contextual effects. The proposed three-level HGLM was examined by analyzing simulated data sets and was compared with the Rasch-equivalent two-level HGLM that ignores such a nested structure of test items. The results demonstrated that the proposed model could capture LID and estimate its magnitude. Also, the two-level HGLM resulted in larger mean absolute differences between the true and the estimated item difficulties than those from the proposed three-level HGLM. Furthermore, it was demonstrated that the proposed three-level HGLM estimated the ability distribution variance unaffected by the LID magnitude, while the two-level HGLM with no LID consideration increasingly underestimated the ability variance as the LID magnitude increased.
Directory of Open Access Journals (Sweden)
Virdi Sarvjit
2009-01-01
Full Text Available Generalized morphea is a disease characterized by wide-spread sclerosis of the skin. A 39-year-old man presented with history of multiple pigmented and bound-down plaques on the body along with mucosal involvement. Dermatological examination showed multiple indurated and sclerosed plaques with follicular plugging in few of them and gross thickened eroded and glazed tongue. The constellation of these findings with histopathological correlation led us to diagnosis of this spectrum of cutaneous involvement. The coexistence of localized morphea with lichen sclerosis et atrophicus has been reported earlier but existence of these entities with submucosal fibrosis in a same patient is documented here and is the first of its kind.
A Bayesian modeling approach for generalized semiparametric structural equation models.
Song, Xin-Yuan; Lu, Zhao-Hua; Cai, Jing-Heng; Ip, Edward Hak-Sing
2013-10-01
In behavioral, biomedical, and psychological studies, structural equation models (SEMs) have been widely used for assessing relationships between latent variables. Regression-type structural models based on parametric functions are often used for such purposes. In many applications, however, parametric SEMs are not adequate to capture subtle patterns in the functions over the entire range of the predictor variable. A different but equally important limitation of traditional parametric SEMs is that they are not designed to handle mixed data types-continuous, count, ordered, and unordered categorical. This paper develops a generalized semiparametric SEM that is able to handle mixed data types and to simultaneously model different functional relationships among latent variables. A structural equation of the proposed SEM is formulated using a series of unspecified smooth functions. The Bayesian P-splines approach and Markov chain Monte Carlo methods are developed to estimate the smooth functions and the unknown parameters. Moreover, we examine the relative benefits of semiparametric modeling over parametric modeling using a Bayesian model-comparison statistic, called the complete deviance information criterion (DIC). The performance of the developed methodology is evaluated using a simulation study. To illustrate the method, we used a data set derived from the National Longitudinal Survey of Youth.
Chronic subordinate colony housing (CSC as a model of chronic psychosocial stress in male rats.
Directory of Open Access Journals (Sweden)
Kewir D Nyuyki
Full Text Available Chronic subordinate colony housing (CSC is an adequate and reliable mouse model of chronic psychosocial stress, resulting in reduced body weight gain, reduced thymus and increased adrenal weight, long-lasting anxiety-like behaviour, and spontaneous colitis. Furthermore, CSC mice show increased corticotrophin (ACTH responsiveness to acute heterotypic stressors, suggesting a general mechanism which allows a chronically-stressed organism to adequately respond to a novel threat. Therefore, the aim of the present study was to extend the CSC model to another rodent species, namely male Wistar rats, and to characterize relevant physiological, immunological, and behavioural consequences; placing particular emphasis on changes in hypothalamo-pituitary-adrenal (HPA axis responsiveness to an acute heterotypic stressor. In line with previous mouse data, exposure of Wistar rats to 19 days of CSC resulted in a decrease in body weight gain and absolute thymus mass, mild colonic barrier defects and intestinal immune activation. Moreover, no changes in stress-coping behaviour or social preference were seen; again in agreement with the mouse paradigm. Most importantly, CSC rats showed an increased plasma corticosterone response to an acute heterotypic stressor (open arm, 5 min despite displaying similar basal levels and similar basal and stressor-induced plasma ACTH levels. In contrast to CSC mice, anxiety-related behaviour and absolute, as well as relative adrenal weights remained unchanged in CSC rats. In summary, the CSC paradigm could be established as an adequate model of chronic psychosocial stress in male rats. Our data further support the initial hypothesis that adrenal hyper-responsiveness to ACTH during acute heterotypic stressors represents a general adaptation, which enables a chronically-stressed organism to adequately respond to novel challenges.
Tsai, Chia-Ching; Chang, Chih-Hsiang
2007-01-01
This study investigates the effect of advertising with physically attractive models on male and female adolescents. The findings suggest that highly attractive models are less effective than those who are normally attractive. Implications of social comparison are discussed.
Tsai, Chia-Ching; Chang, Chih-Hsiang
2007-01-01
This study investigates the effect of advertising with physically attractive models on male and female adolescents. The findings suggest that highly attractive models are less effective than those who are normally attractive. Implications of social comparison are discussed.
Generalization of Random Intercept Multilevel Models
Directory of Open Access Journals (Sweden)
Rehan Ahmad Khan
2013-10-01
Full Text Available The concept of random intercept models in a multilevel model developed by Goldstein (1986 has been extended for k-levels. The random variation in intercepts at individual level is marginally split into components by incorporating higher levels of hierarchy in the single level model. So, one can control the random variation in intercepts by incorporating the higher levels in the model.
Piumatti, Giovanni
2017-01-31
This study aimed to better understand the relationship between religiosity and anti-homosexual attitudes in Italy by examining the mediation effects of male role endorsement and homosexual stereotyping. A sample of 5,522 Italian residents (age range = 18-74) was drawn from a cross-sectional national representative survey carried out in 2011. Measures included general religiosity, male role endorsement, homosexual stereotyping, social acceptance of homosexuality, and homosexual rights endorsement. Structural equation modeling was used to test the mediational effects of male role endorsement and homosexual stereotyping on the relationship between general religiosity and attitudes toward lesbians and gay men. Results showed that both male role endorsement and homosexual stereotyping partially mediated the relationship. In a model where religiosity and both mediators positively explained anti-homosexual attitudes, male role endorsement was the strongest mediator. Endorsement of gender role beliefs and homosexual stereotyping may thus exacerbate the connection between religiosity and anti-homosexual attitudes among Italians.
Assortativity in generalized preferential attachment models
Krot, Alexander
2016-01-01
In this paper, we analyze assortativity of preferential attachment models. We deal with a wide class of preferential attachment models (PA-class). It was previously shown that the degree distribution in all models of the PA-class follows a power law. Also, the global and the average local clustering coefficients were analyzed. We expand these results by analyzing the assortativity property of the PA-class of models. Namely, we analyze the behavior of $d_{nn}(d)$ which is the average degree of a neighbor of a vertex of degree $d$.
Particle model with generalized Poincaré symmetry
Smith, A.
2017-08-01
Using the techniques of nonlinear coset realization with a generalized Poincaré group, we construct a relativistic particle model, invariant under the generalized symmetries, providing a dynamical realization of the B5 algebra.
Stratospheric General Circulation with Chemistry Model (SGCCM)
Rood, Richard B.; Douglass, Anne R.; Geller, Marvin A.; Kaye, Jack A.; Nielsen, J. Eric; Rosenfield, Joan E.; Stolarski, Richard S.
1990-01-01
In the past two years constituent transport and chemistry experiments have been performed using both simple single constituent models and more complex reservoir species models. Winds for these experiments have been taken from the data assimilation effort, Stratospheric Data Analysis System (STRATAN).
Generalized coupling in the Kuramoto model
DEFF Research Database (Denmark)
Filatrella, G.; Pedersen, Niels Falsig; Wiesenfeld, K.
2007-01-01
We propose a modification of the Kuramoto model to account for the effective change in the coupling constant among the oscillators, as suggested by some experiments on Josephson junction, laser arrays, and mechanical systems, where the active elements are turned on one by one. The resulting model...... with the behavior of Josephson junctions coupled via a cavity....
A model for group counseling with male pedophiles.
van Zessen, G
1990-01-01
Group treatment programs for pedophiles are often designed for populations of convicted men in closed institutions with limited application to other populations. Treatment is usually focused on reducing the "deviant" sexual arousal and/or acquiring heterosocial skills and eventually establishing the ability to engage in adult heterosexual relationships. A six-week, highly structured program is presented to five men in a non-residential setting. In addition to individual psychotherapy, group counseling is offered. Male pedophiles are trained to talk effectively about common problems surrounding man-boy relationships. Counseling is based on the notion that the emotional, erotic and sexual attraction to boys per se does not need to be legitimized or modified. The attraction, however, can be a source of psychological and social problems that can be handled by using a social support system. Social support for pedophile problems can be obtained from and in interaction with other pedophiles.
Universality in generalized models of inflation
Binétruy, Pierre; Pieroni, Mauro
2016-01-01
We show that the cosmological evolution of a scalar field with non standard kinetic term can be described in terms of a Renormalization Group Equation. In this framework inflation corresponds to the slow evolution in a neighborhood of a fixed point and universality classes for inflationary models can be naturally introduced. Using some examples we show the application of the formalism. The predicted values for the speed of sound $c_s$ and for the amount of non-Gaussianities produced in these models are discussed. In particular, we show that it is possible to introduce models with $c_s^2 \
The Survival Probability in Generalized Poisson Risk Model
Institute of Scientific and Technical Information of China (English)
GONGRi-zhao
2003-01-01
In this paper we generalize the aggregated premium income process from a constant rate process to a poisson process for the classical compound Poinsson risk model,then for the generalized model and the classical compound poisson risk model ,we respectively get its survival probability in finite time period in case of exponential claim amounts.
Description of the General Equilibrium Model of Ecosystem Services (GEMES)
Travis Warziniack; David Finnoff; Jenny Apriesnig
2017-01-01
This paper serves as documentation for the General Equilibrium Model of Ecosystem Services (GEMES). GEMES is a regional computable general equilibrium model that is composed of values derived from natural capital and ecosystem services. It models households, producing sectors, and governments, linked to one another through commodity and factor markets. GEMES was...
Evidence for a General Factor Model of ADHD in Adults
Gibbins, Christopher; Toplak, Maggie E.; Flora, David B.; Weiss, Margaret D.; Tannock, Rosemary
2012-01-01
Objective: To examine factor structures of "Diagnostic and Statistical Manual of Mental Disorders" (4th ed.) symptoms of ADHD in adults. Method: Two sets of models were tested: (a) models with inattention and hyperactivity/impulsivity as separate but correlated latent constructs and (b) hierarchical general factor models with a general factor for…
BEYOND SEM: GENERAL LATENT VARIABLE MODELING
National Research Council Canada - National Science Library
Muthén, Bengt O
2002-01-01
This article gives an overview of statistical analysis with latent variables. Using traditional structural equation modeling as a starting point, it shows how the idea of latent variables captures a wide variety of statistical concepts...
Generalized circuit model for coupled plasmonic systems
Benz, Felix; Tserkezis, Christos; Chikkaraddy, Rohit; Sigle, Daniel O; Pukenas, Laurynas; Evans, Stephen D; Aizpurua, Javier; Baumberg, Jeremy J
2015-01-01
We develop an analytic circuit model for coupled plasmonic dimers separated by small gaps that provides a complete account of the optical resonance wavelength. Using a suitable equivalent circuit, it shows how partially conducting links can be treated and provides quantitative agreement with both experiment and full electromagnetic simulations. The model highlights how in the conducting regime, the kinetic inductance of the linkers set the spectral blue-shifts of the coupled plasmon.
A Research Brief: A Novel Characteristic of Role Model Choice by Black Male College Students
Bennett, B. J.; Davis, R.; Harris, A.; Brown, K.; Wood, P.; Jones, D. R.; Spencer, S.; Nelson, L.; Brown, J.; Waddell, T.; Jones, C. B.
2004-01-01
The purpose of the present research brief is to report a novel characteristic of role model choice that may be unreported in the literature for black males and to assess this finding in relation to perceived attractiveness of self and a member of the opposite sex. The study found that the proportion of males choosing themselves as their own role…
Animal models of physiologic markers of male reproduction: genetically defined infertile mice
Energy Technology Data Exchange (ETDEWEB)
Chubb, C.
1987-10-01
The present report focuses on novel animal models of male infertility: genetically defined mice bearing single-gene mutations that induce infertility. The primary goal of the investigations was to identify the reproductive defects in these mutant mice. The phenotypic effects of the gene mutations were deciphered by comparing the mutant mice to their normal siblings. Initially testicular steroidogenesis and spermatogenesis were investigated. The physiologic markers for testicular steroidogenesis were steroid secretion by testes perifused in vitro, seminal vesicle weight, and Leydig cell histology. Spermatogenesis was evaluated by the enumeration of homogenization-resistant sperm/spermatids in testes and by morphometric analyses of germ cells in the seminiferous epithelium. If testicular function appeared normal, the authors investigated the sexual behavior of the mice. The parameters of male sexual behavior that were quantified included mount patency, mount frequency, intromission latency, thrusts per intromission, ejaculation latency, and ejaculation duration. Females of pairs breeding under normal circumstances were monitored for the presence of vaginal plugs and pregnancies. The patency of the ejaculatory process was determined by quantifying sperm in the female reproductive tract after sexual behavior tests. Sperm function was studied by quantitatively determining sperm motility during videomicroscopic observation. Also, the ability of epididymal sperm to function within the uterine environment was analyzed by determining sperm capacity to initiate pregnancy after artificial insemination. Together, the experimental results permitted the grouping of the gene mutations into three general categories. They propose that the same biological markers used in the reported studies can be implemented in the assessment of the impact that environmental toxins may have on male reproduction.
Invariance Properties for General Diagnostic Classification Models
Bradshaw, Laine P.; Madison, Matthew J.
2016-01-01
In item response theory (IRT), the invariance property states that item parameter estimates are independent of the examinee sample, and examinee ability estimates are independent of the test items. While this property has long been established and understood by the measurement community for IRT models, the same cannot be said for diagnostic…
A General Thermal Equilibrium Discharge Flow Model
Institute of Scientific and Technical Information of China (English)
ZHAO; Min-fu; ZHANG; Dong-xu; LV; Yu-feng
2015-01-01
In isentropic and thermal equilibrium assumptions,a discharge flow model was derived,which unified the rules of normal temperature water discharge,high temperature and high pressure water discharge,two-phase critical flow,saturated steam and superheated steam critical
A generalized network model for polymeric liquids
Jongschaap, R.J.J.; Kamphuis, H.; Doeksen, D.K.
1983-01-01
A kinetic model was developed for relating the molecular structure and the rheological behaviour of polymer-like materials in which bonds are being created and broken. In particular, the stress contribution of molecules that are not a part of the network was taken account of. In two limiting cases
On A General Frame For Macroeconomic Modelling
Directory of Open Access Journals (Sweden)
Emil DINGA
2012-03-01
Full Text Available The purpose of the research project was to identify the methodological bases for the aggregate description of the Romanian national economy, both logically and in terms of the sources of empirical data for modelling. The specific objectives of the project were: a description of the economic markets in correlation with the logic description of the economic behaviours; b determination of the sectoral blocks of the Romanian economy, on the basis of the homogeneity of the economic; activity and behaviour; c association of the sectoral blocks to the national accounts, so as to ensure the sources of empirical data for the calibration and utilisation of the model; d association of the sectoral blocks to the economic markets; e association of the national accounts with the economic markets; f identification of the classes of interactions between the determined sectoral blocks.
Generalized Quadratic Linearization of Machine Models
Parvathy Ayalur Krishnamoorthy; Kamaraj Vijayarajan; Devanathan Rajagopalan
2011-01-01
In the exact linearization of involutive nonlinear system models, the issue of singularity needs to be addressed in practical applications. The approximate linearization technique due to Krener, based on Taylor series expansion, apart from being applicable to noninvolutive systems, allows the singularity issue to be circumvented. But approximate linearization, while removing terms up to certain order, also introduces terms of higher order than those removed into the system. To overcome th...
Generalized Mathematical Model for Hot Rolling Process of Plate
Institute of Scientific and Technical Information of China (English)
Zhenshan CUI; Bingye XU
2003-01-01
A generalized mathematical model is developed to predict the changes of temperature, rolling pressure, strain,strain rate, and austenite grain size for plate hot rolling and cooling processes. The model is established mainly by incorporating analytical an
A Unified Model of All Generalizations from the Jones Polynomial
Institute of Scientific and Technical Information of China (English)
QIAN Shang-Wu; GU Zhi-Yu
2001-01-01
From the basic properties of skein systems, we build a generalized tangle algebra (GTA). The elements of GTA are four basic tangles. There are three operations, which are connection, splicing and scalar multiplication. From GTA we derive two generalized recursion formulae (GRF) and prove the existence of a generalized skein relation which satisfies GRF. The obtained generalized skein relation epitomizes all generalizations from the Jones polynomial and thus forms a unified model. Two important topological parameters, twisting measure and loop values, appear explicitly in the expressions of the unified model, and this fact greatly simplifies the operations.
The General Optimal Market Area Model
1988-06-01
Spatial Competition, American Economic Review 68 (1978) 896. [19] G.M. Carter, J.M. Chaiken, and E. Ignall, Response Areas for Two Emergency Units...25] B.C. Eaton and R.G. Lipsey, The Non-Uniqueness of Equilibrium in the L6schian Location Model, American Economic Review 66 (1976) 77. [26, B.C...4 (1972) 154. [86] S. Valavanis, L6sch on Location, American Economic Review 45 (1955) 637. [87] B. Von Hohenbalken and D.S. West, Manhattan versus
A study of male reproductive form and function in a rat model
Mark Daniel Wilson
2014-01-01
Objective: This investigation was undertaken in the hope of delineating the effects of four different treatments on male reproductive biology in a rat model. The effect of cryptorchidism, gonadectomy, pharmacological ablation of Leydig cell function and androgen-treatment was examined; these four treatments illustrate four different factors influencing and controlling male sexual function in a reproducible animal model. Methods: Total body weight, androgen concentration, gonad weight and s...
Body composition by a three compartment model in adult Indian male and female subjects.
Borgonha, S; Kuriyan, R; Shetty, P; Ferro-Luzzi, A; Kurpad, A V
1997-07-01
The body composition of 10 adult Indian male and female subjects was investigated by a three compartment model, using measurements of Total Body Water (TBW) by deuterium dilution, and of body density by hydrodensitometry. The three compartment model yielded significantly different (P hydrodensitometry, was 1.107+/-0.014 in the males and 1.101+/-0.001 in the females with no significant differences between the groups. This study demonstrates differences in body composition between BMI matched healthy adult male and female subjects. Although there are significant differences for % Fat and FFM between the sexes, there are no significant differences in the hydration fraction and the density of the FFM.
Modeling electrokinetics in ionic liquids: General
Energy Technology Data Exchange (ETDEWEB)
Wang, Chao [Physical and Computational Science Directorate, Pacific Northwest National Laboratory, Richland WA USA; Bao, Jie [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland WA USA; Pan, Wenxiao [Department of Mechanical Engineering, University of Wisconsin-Madison, Madison WI USA; Sun, Xin [Physical and Computational Science Directorate, Pacific Northwest National Laboratory, Richland WA USA
2017-04-07
Using direct numerical simulations we provide a thorough study on the electrokinetics of ionic liquids. In particular, the modfied Poisson-Nernst-Planck (MPNP) equations are solved to capture the crowding and overscreening effects that are the characteristics of an ionic liquid. For modeling electrokinetic flows in an ionic liquid, the MPNP equations are coupled with the Navier-Stokes equations to study the coupling of ion transport, hydrodynamics, and electrostatic forces. Specifically, we consider the ion transport between two parallel plates, charging dynamics in a 2D straight-walled pore, electro-osmotic ow in a nano-channel, electroconvective instability on a plane ion-selective surface, and electroconvective ow on a curved ion-selective surface. We discuss how the crowding and overscreening effects and their interplay affect the electrokinetic behaviors of ionic liquids in these application problems.
Building a generalized distributed system model
Mukkamala, R.
1992-01-01
The key elements in the second year (1991-92) of our project are: (1) implementation of the distributed system prototype; (2) successful passing of the candidacy examination and a PhD proposal acceptance by the funded student; (3) design of storage efficient schemes for replicated distributed systems; and (4) modeling of gracefully degrading reliable computing systems. In the third year of the project (1992-93), we propose to: (1) complete the testing of the prototype; (2) enhance the functionality of the modules by enabling the experimentation with more complex protocols; (3) use the prototype to verify the theoretically predicted performance of locking protocols, etc.; and (4) work on issues related to real-time distributed systems. This should result in efficient protocols for these systems.
A generalized model via random walks for information filtering
Energy Technology Data Exchange (ETDEWEB)
Ren, Zhuo-Ming, E-mail: zhuomingren@gmail.com [Department of Physics, University of Fribourg, Chemin du Musée 3, CH-1700, Fribourg (Switzerland); Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, ChongQing, 400714 (China); Kong, Yixiu [Department of Physics, University of Fribourg, Chemin du Musée 3, CH-1700, Fribourg (Switzerland); Shang, Ming-Sheng, E-mail: msshang@cigit.ac.cn [Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, ChongQing, 400714 (China); Zhang, Yi-Cheng [Department of Physics, University of Fribourg, Chemin du Musée 3, CH-1700, Fribourg (Switzerland)
2016-08-06
There could exist a simple general mechanism lurking beneath collaborative filtering and interdisciplinary physics approaches which have been successfully applied to online E-commerce platforms. Motivated by this idea, we propose a generalized model employing the dynamics of the random walk in the bipartite networks. Taking into account the degree information, the proposed generalized model could deduce the collaborative filtering, interdisciplinary physics approaches and even the enormous expansion of them. Furthermore, we analyze the generalized model with single and hybrid of degree information on the process of random walk in bipartite networks, and propose a possible strategy by using the hybrid degree information for different popular objects to toward promising precision of the recommendation. - Highlights: • We propose a generalized recommendation model employing the random walk dynamics. • The proposed model with single and hybrid of degree information is analyzed. • A strategy with the hybrid degree information improves precision of recommendation.
A general and simple method for obtaining R2 from generalized linear mixed‐effects models
National Research Council Canada - National Science Library
Nakagawa, Shinichi; Schielzeth, Holger; O'Hara, Robert B
2013-01-01
The use of both linear and generalized linear mixed‐effects models ( LMM s and GLMM s) has become popular not only in social and medical sciences, but also in biological sciences, especially in the field of ecology and evolution...
Intermediate-generalized Chaplygin gas inflationary universe model
Energy Technology Data Exchange (ETDEWEB)
Herrera, Ramon; Olivares, Marco; Videla, Nelson [Pontificia Universidad Catolica de Valparaiso, Instituto de Fisica, Casilla, Valparaiso (Chile)
2013-01-15
An intermediate inflationary universe model in the context of a generalized Chaplygin gas is considered. For the matter we consider two different energy densities; a standard scalar field and a tachyon field, respectively. In general, we discuss the conditions of an inflationary epoch for these models. We also, use recent astronomical observations from Wilkinson Microwave Anisotropy Probe seven year data for constraining the parameters appearing in our models. (orig.)
Consoli, Daniele; Fedotova, Julia; Micale, Vincenzo; Sapronov, Nikolay S; Drago, Filippo
2005-09-27
Aim of the present study was to evaluate the effects of physical stressors (electric foot-shocks) on effect of the antidepressant drug, clomipramine and plasma corticosterone levels in male and female rats tested in a model of behavioral despair (forced swim test,). Male and female rats of the Wistar strain were injected with clomipramine (50 mg/kg, i.p.) or saline. A group of animals also received electric shocks of different intensity and duration of 24, 5 and 1 h before being subjected to forced swim test. At the end of behavioral procedures, vaginal smears were assessed in all female animals and data on immobility time were plotted according to the ovarian cycle phase. After decapitation, corticosterone plasma levels were measured by radioimmunoassay in both male and female rats. Application of mild shocks (5 ms, 0.1 mA) significantly reduced immobility time in forced swim test of untreated male rats and augmented clomipramine effect on this parameter. Moderate shocks of higher intensity or duration (5 ms, 1.0 mA) also resulted in decreased immobility time of untreated male rats, but in reduced effect of clomipramine treatment. Furthermore, application of severe shocks (10 ms, 1.0 mA) increased the immobility time in untreated animals and totally abolished clomipramine effect in forced swim test. Untreated non-shocked female rats in proestrous and estrous phases exhibited a longer immobility time as compared to diestrous animals. Immobility time appeared to be generally higher when mild, moderate or severe shocks were applied prior to behavioral testing in proestrous and estrous animals, while the behavioral response of diestrous and metestrous animals did not differ from that of controls. Clomipramine effect on immobility time was generally reduced by application of shocks of every strengths. Stress-induced plasma corticosterone levels surge correlated with intensity and duration of shocks in both male and female rats, but clomipramine treatment generally
A logistic regression model of Coronary Artery Disease among Male Patients in Punjab
Directory of Open Access Journals (Sweden)
Sohail Chand
2005-07-01
Full Text Available This is a cross-sectional retrospective study of 308 male patients, who were presented first time for coronary angiography at the Punjab Institute of Cardiology. The mean age was 50.97 + 9.9 among male patients. As the response variable coronary artery disease (CAD was a binary variable, logistic regression model was fitted to predict the Coronary Artery Disease with the help of significant risk factors. Age, Chest pain, Diabetes Mellitus, Smoking and Lipids are resulted as significant risk factors associated with CAD among male population.
Generalized Linear Models with Applications in Engineering and the Sciences
Myers, Raymond H; Vining, G Geoffrey; Robinson, Timothy J
2012-01-01
Praise for the First Edition "The obvious enthusiasm of Myers, Montgomery, and Vining and their reliance on their many examples as a major focus of their pedagogy make Generalized Linear Models a joy to read. Every statistician working in any area of applied science should buy it and experience the excitement of these new approaches to familiar activities."-Technometrics Generalized Linear Models: With Applications in Engineering and the Sciences, Second Edition continues to provide a clear introduction to the theoretical foundations and key applications of generalized linear models (GLMs). Ma
Kalman Filter for Generalized 2-D Roesser Models
Institute of Scientific and Technical Information of China (English)
SHENG Mei; ZOU Yun
2007-01-01
The design problem of the state filter for the generalized stochastic 2-D Roesser models, which appears when both the state and measurement are simultaneously subjected to the interference from white noise, is discussed. The wellknown Kalman filter design is extended to the generalized 2-D Roesser models. Based on the method of "scanning line by line", the filtering problem of generalized 2-D Roesser models with mode-energy reconstruction is solved. The formula of the optimal filtering, which minimizes the variance of the estimation error of the state vectors, is derived. The validity of the designed filter is verified by the calculation steps and the examples are introduced.
A General Polygon-based Deformable Model for Object Recognition
DEFF Research Database (Denmark)
Jensen, Rune Fisker; Carstensen, Jens Michael
1999-01-01
We propose a general scheme for object localization and recognition based on a deformable model. The model combines shape and image properties by warping a arbitrary prototype intensity template according to the deformation in shape. The shape deformations are constrained by a probabilistic...... distribution, which combined with a match of the warped intensity template and the image form the final criteria used for localization and recognition of a given object. The chosen representation gives the model an ability to model an almost arbitrary object. Beside the actual model a full general scheme...
Directory of Open Access Journals (Sweden)
A. V. Kovalev
2015-06-01
Full Text Available We propose an agentbased simulation model search. This model allows us to evaluate the effectiveness of different malesfemales pheromone search strategies for Lepidoptera. In the model, we consider the simplest case of the search, when the pheromone has only one chemical component. It is assumed that the insects are able to detect the pheromone molecules and the sensory cells generate action potentials in contact with the pheromone for some time. Thereafter pheromone molecule is inactivated. This behavior can be regarded as a memory of individual. Proportion of individuals who have reached the source is selected as an integral indicator of the search efficiency. To evaluate the effectiveness, numeric experiments were performed in different conditions: random walk, search algorithm without memory, and algorithm with memory and return mechanism. The resulting effectiveness of source localization by insects for flight in turbulent flows is ~ 70 %, which corresponds to experiments with live specimens in literature. In this case, proposed pheromone search algorithm is quite simple, which makes it biologically correct. Conducted modeling calculations can be the starting point for planning of field observations and pest monitoring systems using pheromone traps.
Calibrating the ECCO ocean general circulation model using Green's functions
Menemenlis, D.; Fu, L. L.; Lee, T.; Fukumori, I.
2002-01-01
Green's functions provide a simple, yet effective, method to test and calibrate General-Circulation-Model(GCM) parameterizations, to study and quantify model and data errors, to correct model biases and trends, and to blend estimates from different solutions and data products.
A Duality Result for the Generalized Erlang Risk Model
Directory of Open Access Journals (Sweden)
Lanpeng Ji
2014-11-01
Full Text Available In this article, we consider the generalized Erlang risk model and its dual model. By using a conditional measure-preserving correspondence between the two models, we derive an identity for two interesting conditional probabilities. Applications to the discounted joint density of the surplus prior to ruin and the deficit at ruin are also discussed.
General Linear Models: An Integrated Approach to Statistics
Andrew Faulkner; Sylvain Chartier
2008-01-01
Generally, in psychology, the various statistical analyses are taught independently from each other. As a consequence, students struggle to learn new statistical analyses, in contexts that differ from their textbooks. This paper gives a short introduction to the general linear model (GLM), in which it is showed that ANOVA (one-way, factorial, repeated measure and analysis of covariance) is simply a multiple correlation/regression analysis (MCRA). Generalizations to other cases, such as multiv...
Parameter Estimation for a Computable General Equilibrium Model
DEFF Research Database (Denmark)
Arndt, Channing; Robinson, Sherman; Tarp, Finn
2002-01-01
We introduce a maximum entropy approach to parameter estimation for computable general equilibrium (CGE) models. The approach applies information theory to estimating a system of non-linear simultaneous equations. It has a number of advantages. First, it imposes all general equilibrium constraints...
Duals for classical inventory models via generalized geometric programming
Carlton H. Scott; Thomas R. Jefferson; Soheila Jorjani
2004-01-01
Inventory problems generally have a structure that can be exploited for computational purposes. Here, we look at the duals of two seemingly unrelated inventory models that suggest an interesting duality between discrete time optimal control and optimization over an ordered sequence of variables. Concepts from conjugate duality and generalized geometric programming are used to establish the duality.
Ising model on the generalized Bruhat-Tits tree
Zinoviev, Yu. M.
1991-08-01
The partition function and the correlation functions of the Ising model on the generalized Bruhat-Tits tree are calculated. We computed also the averages of these correlation functions when the corresponding vertices are attached to the boundary of the generalized Bruhat-Tits tree.
Parameter Estimation for a Computable General Equilibrium Model
DEFF Research Database (Denmark)
Arndt, Channing; Robinson, Sherman; Tarp, Finn
We introduce a maximum entropy approach to parameter estimation for computable general equilibrium (CGE) models. The approach applies information theory to estimating a system of nonlinear simultaneous equations. It has a number of advantages. First, it imposes all general equilibrium constraints...
Study on Solitary Waves of a General Boussinesq Model
Institute of Scientific and Technical Information of China (English)
无
2007-01-01
In this paper, we employ the bifurcation method of dynamical systems to study the solitary waves and periodic waves of a generalized Boussinesq equations. All possible phase portraits in the parameter plane for the travelling wave systems are obtained. The possible solitary wave solutions, periodic wave solutions and cusp waves for the general Boussinesq type fluid model are also investigated.
Finite Element Modeling of Metasurfaces with Generalized Sheet Transition Conditions
Sandeep, Srikumar; Caloz, Christophe
2016-01-01
A modeling of metasurfaces in the finite element method (FEM) based on generalized sheet transition conditions (GSTCs) is presented. The discontinuities in electromagnetic fields across a metasurface as represented by the GSTC are modeled by assigning nodes to both sides of the metasurface. The FEM-GSTC formulation in both 1D and 2D domains is derived and implemented. The method is extended to handle more general bianistroptic metasurfaces. The formulations are validated by several illustrative examples.
A QCD Model Using Generalized Yang-Mills Theory
Institute of Scientific and Technical Information of China (English)
WANG Dian-Fu; SONG He-Shan; KOU Li-Na
2007-01-01
Generalized Yang-Mills theory has a covariant derivative,which contains both vector and scalar gauge bosons.Based on this theory,we construct a strong interaction model by using the group U(4).By using this U(4)generalized Yang-Mills model,we also obtain a gauge potential solution,which can be used to explain the asymptotic behavior and color confinement.
Dynamical CP violation of the generalized Yang-Mills model
Institute of Scientific and Technical Information of China (English)
WANG Dian-Fu; SUN Xiao-Yu; CHANG Xiao-Jing
2011-01-01
Starting from the generalized Yang-Mills model which contains, besides the vector part Vμ, also a scalar part S and a pseudoscalar part P. It is shown, in terms of the Nambu-Jona-Lasinio (NJL) mechanism,that CP violation can be realized dynamically. The combination of the generalized Yang-MiUs model and the NJL mechanism provides a new way to explain CP violation.
Institute of Scientific and Technical Information of China (English)
Rendao YE; Songgui WANG
2007-01-01
Various random models with balanced data that are relevant for analyzing practical test data are described, along with several hypothesis testing and interval estimation problems concerning variance components. In this paper, we mainly consider these problems in general random effect model with balanced data. Exact tests and confidence intervals for a single variance component corresponding to random effect are developed by using generalized p-values and generalized confidence intervals.The resulting procedures are easy to compute and are applicable to small samples. Exact tests and confidence intervals are also established for comparing the random-effects variance components and the sum of random-effects variance components in two independent general random effect models with balanced data. Furthermore, we investigate the statistical properties of the resulting tests. Finally,some simulation results on the type Ⅰ error probability and power of the proposed test are reported.The simulation results indicate that exact test is extremely satisfactory for controlling type Ⅰ error probability.
Inflationary Weak Anisotropic Model with General Dissipation Coefficient
Sharif, M
2015-01-01
This paper explores the dynamics of warm intermediate and logamediate inflationary models during weak dissipative regime with a general form of dissipative coefficient. We analyze these models within the framework of locally rotationally symmetric Bianchi type I universe. In both cases, we evaluate solution of inflaton, effective scalar potential, dissipative coefficient, slow-roll parameters, scalar and tensor power spectra, scalar spectral index and tensor to scalar ratio under slow-roll approximation. We constrain the model parameters using recent data and conclude that anisotropic inflationary universe model with generalized dissipation coefficient remains compatible with WMAP9, Planck and BICEP2 data.
Extending the generalized Chaplygin gas model by using geometrothermodynamics
Aviles, Alejandro; Campuzano, Lorena; Quevedo, Hernando
2012-01-01
We use the formalism of geometrothermodynamics (GTD) to derive fundamental thermodynamic equations that are used to construct general relativistic cosmological models. In particular, we show that the simplest possible fundamental equation, which corresponds in GTD to a system with no internal thermodynamic interaction, describes the different fluids of the standard model of cosmology. In addition, a particular fundamental equation with internal thermodynamic interaction is shown to generate a new cosmological model that correctly describes the dark sector of the Universe and contains as a special case the generalized Chaplygin gas model.
African wave disturbances in a general circulation model
Estoque, M. A.; Jiing, J. G.; Shukla, J.
1983-01-01
Evidence is presented to show that African wave disturbances are reproduced in a general circulation simulation. The model used is the general circulation model developed by the Goddard Laboratory for Atmospheric Sciences of the National Aeronautics and Space Agency. The model was integrated in order to simulate the summer of 1974. A synoptic analysis of the simulated data over Africa for the month of July was done. The results of the analysis show that wave disturbances are generated by the model; the behavior and the structure of the simulated disturbances are similar to those observed over tropical Africa during the northern summer.
Generalized continua as models for classical and advanced materials
Forest, Samuel
2016-01-01
This volume is devoted to an actual topic which is the focus world-wide of various research groups. It contains contributions describing the material behavior on different scales, new existence and uniqueness theorems, the formulation of constitutive equations for advanced materials. The main emphasis of the contributions is directed on the following items - Modelling and simulation of natural and artificial materials with significant microstructure, - Generalized continua as a result of multi-scale models, - Multi-field actions on materials resulting in generalized material models, - Theories including higher gradients, and - Comparison with discrete modelling approaches.
General Friction Model Extended by the Effect of Strain Hardening
DEFF Research Database (Denmark)
Nielsen, Chris V.; Martins, Paulo A.F.; Bay, Niels
2016-01-01
An extension to the general friction model proposed by Wanheim and Bay [1] to include the effect of strain hardening is proposed. The friction model relates the friction stress to the fraction of real contact area by a friction factor under steady state sliding. The original model for the real co...... of friction in metal forming, where the material generally strain hardens. The extension of the model to cover strain hardening materials is validated by comparison to previously published experimental data.......An extension to the general friction model proposed by Wanheim and Bay [1] to include the effect of strain hardening is proposed. The friction model relates the friction stress to the fraction of real contact area by a friction factor under steady state sliding. The original model for the real......-ideally plastic material, and secondly, to extend the solution by the influence of material strain hardening. This corresponds to adding a new variable and, therefore, a new axis to the general friction model. The resulting model is presented in a combined function suitable for e.g. finite element modeling...
Pricing Participating Products under a Generalized Jump-Diffusion Model
Directory of Open Access Journals (Sweden)
Tak Kuen Siu
2008-01-01
Full Text Available We propose a model for valuing participating life insurance products under a generalized jump-diffusion model with a Markov-switching compensator. It also nests a number of important and popular models in finance, including the classes of jump-diffusion models and Markovian regime-switching models. The Esscher transform is employed to determine an equivalent martingale measure. Simulation experiments are conducted to illustrate the practical implementation of the model and to highlight some features that can be obtained from our model.
A Generalized Rough Set Modeling Method for Welding Process
Institute of Scientific and Technical Information of China (English)
无
2007-01-01
Modeling is essential, significant and difficult for the quality and shaping control of arc welding process. A generalized rough set based modeling method was brought forward and a dynamic predictive model for pulsed gas tungsten arc welding (GTAW) was obtained by this modeling method. The results show that this modeling method can well acquire knowledge in welding and satisfy the real life application. In addition, the results of comparison between classic rough set model and back-propagation neural network model respectively are also satisfying.
Adaptation of a general circulation model to ocean dynamics
Turner, R. E.; Rees, T. H.; Woodbury, G. E.
1976-01-01
A primitive-variable general circulation model of the ocean was formulated in which fast external gravity waves are suppressed with rigid-lid surface constraint pressires which also provide a means for simulating the effects of large-scale free-surface topography. The surface pressure method is simpler to apply than the conventional stream function models, and the resulting model can be applied to both global ocean and limited region situations. Strengths and weaknesses of the model are also presented.
Model Reduction of Switched Systems Based on Switching Generalized Gramians
DEFF Research Database (Denmark)
Shaker, Hamid Reza; Wisniewski, Rafal
2012-01-01
In this paper, a general method for model order reduction of discrete-time switched linear systems is presented. The proposed technique uses switching generalized gramians. It is shown that several classical reduction methods can be developed into the generalized gramian framework for the model r......-Galerkin projection is constructed instead of the similarity transform approach for reduction. It is proven that the proposed reduction framework preserves the stability of the original switched system. The performance of the method is illustrated by numerical examples....
Generalized multidirectional fuzzy map model of the logistics system networks
Ji, Chun-Rong; Liu, Ming-Yuan; Li, Yan; He, Yue M.
1997-07-01
By conducting [0, 1] treatment to time consuming of logistics system network key links, and regarding the time consumed by manufacture, inspection, storage, assembling, packing and market as a kind of existent extent of the joint and the time consumed by materials handling, transportation and logistics information as the connection strength between joints in a generalized multi-directional fuzzy map, a generalized multi-directional fuzzy map model of logistics system networks is built. The mutual flow among network joints and the special form of generalized fuzzy matrix is analyzed. Finally, an example of model building is given.
General autocatalytic theory and simple model of financial markets
Thuy Anh, Chu; Lan, Nguyen Tri; Viet, Nguyen Ai
2015-06-01
The concept of autocatalytic theory has become a powerful tool in understanding evolutionary processes in complex systems. A generalization of autocatalytic theory was assumed by considering that the initial element now is being some distribution instead of a constant value as in traditional theory. This initial condition leads to that the final element might have some distribution too. A simple physics model for financial markets is proposed, using this general autocatalytic theory. Some general behaviours of evolution process and risk moment of a financial market also are investigated in framework of this simple model.
Directory of Open Access Journals (Sweden)
Sara Caceres
2016-01-01
Full Text Available Canine inflammatory mammary cancer (IMC shares clinical and histopathological characteristics with human inflammatory breast cancer (IBC and has been proposed as a good model for studying the human disease. The aim of this study was to evaluate the capacity of female and male mice to reproduce IMC and IBC tumors and identify the hormonal tumor environment. To perform the study sixty 6–8-week-old male and female mice were inoculated subcutaneously with a suspension of 106 IPC-366 and SUM149 cells. Tumors and serum were collected and used for hormonal analysis. Results revealed that IPC-366 reproduced tumors in 90% of males inoculated after 2 weeks compared with 100% of females that reproduced tumor at the same time. SUM149 reproduced tumors in 40% of males instead of 80% of females that reproduced tumors after 4 weeks. Both cell lines produce distant metastasis in lungs being higher than the metastatic rates in females. EIA analysis revealed that male tumors had higher T and SO4E1 concentrations compared to female tumors. Serum steroid levels were lower than those found in tumors. In conclusion, IBC and IMC male mouse model is useful as a tool for IBC research and those circulating estrogens and intratumoral hormonal levels are crucial in the development and progression of tumors.
A generalized statistical model for the size distribution of wealth
Clementi, F.; Gallegati, M.; Kaniadakis, G.
2012-12-01
In a recent paper in this journal (Clementi et al 2009 J. Stat. Mech. P02037), we proposed a new, physically motivated, distribution function for modeling individual incomes, having its roots in the framework of the κ-generalized statistical mechanics. The performance of the κ-generalized distribution was checked against real data on personal income for the United States in 2003. In this paper we extend our previous model so as to be able to account for the distribution of wealth. Probabilistic functions and inequality measures of this generalized model for wealth distribution are obtained in closed form. In order to check the validity of the proposed model, we analyze the US household wealth distributions from 1984 to 2009 and conclude an excellent agreement with the data that is superior to any other model already known in the literature.
Classical tests of general relativity in brane world models
Energy Technology Data Exchange (ETDEWEB)
Boehmer, Christian G [Department of Mathematics and Institute of Origins, University College London, Gower Street, London WC1E 6BT (United Kingdom); De Risi, Giuseppe [Dipartimento di Fisica, Universita degli studi di Bari and Istituto Nazionale di Fisica Nucleare, sez. di Bari, Via G. Amendola 173, 70126 Bari (Italy); Harko, Tiberiu [Department of Physics and Center for Theoretical and Computational Physics, University of Hong Kong, Pok Fu Lam Road (Hong Kong); Lobo, Francisco S N, E-mail: c.boehmer@ucl.ac.u, E-mail: giuseppe.derisi@ba.infn.i, E-mail: harko@hkucc.hku.h, E-mail: flobo@cii.fc.ul.p [Centro de Astronomia e Astrofisica da Universidade de Lisboa, Campo Grande, Ed. C8 1749-016 Lisboa (Portugal)
2010-09-21
The classical tests of general relativity (perihelion precession, deflection of light and the radar echo delay) are considered for several spherically symmetric static vacuum solutions in brane world models. Generally, the spherically symmetric vacuum solutions of the brane gravitational field equations have properties quite distinct as compared to the standard black hole solutions of general relativity. As a first step a general formalism that facilitates the analysis of general relativistic Solar System tests for any given spherically symmetric metric is developed. It is shown that the existing observational Solar System data on the perihelion shift of Mercury, on the light bending around the Sun (obtained using long-baseline radio interferometry), and ranging to Mars using the Viking lander constrain the numerical values of the parameters of the specific models.
Classical tests of general relativity in brane world models
Boehmer, Christian G; Harko, Tiberiu; Lobo, Francisco S N
2009-01-01
The classical tests of general relativity (perihelion precession, deflection of light, and the radar echo delay) are considered for several spherically symmetric static vacuum solutions in brane world models. Generally, the spherically symmetric vacuum solutions of the brane gravitational field equations have properties quite distinct as compared to the standard black hole solutions of general relativity. As a first step a general formalism that facilitates the analysis of general relativistic Solar System tests for any given spherically symmetric metric is developed. It is shown that the existing observational Solar System data on the perihelion shift of Mercury, on the light bending around the Sun (obtained using long-baseline radio interferometry), and ranging to Mars using the Viking lander, constrain the numerical values of the parameters of the specific models. Hence Solar System tests represent very convenient and efficient tools to test the viability of the different black hole solutions in brane worl...
A generalized model via random walks for information filtering
Ren, Zhuo-Ming; Kong, Yixiu; Shang, Ming-Sheng; Zhang, Yi-Cheng
2016-08-01
There could exist a simple general mechanism lurking beneath collaborative filtering and interdisciplinary physics approaches which have been successfully applied to online E-commerce platforms. Motivated by this idea, we propose a generalized model employing the dynamics of the random walk in the bipartite networks. Taking into account the degree information, the proposed generalized model could deduce the collaborative filtering, interdisciplinary physics approaches and even the enormous expansion of them. Furthermore, we analyze the generalized model with single and hybrid of degree information on the process of random walk in bipartite networks, and propose a possible strategy by using the hybrid degree information for different popular objects to toward promising precision of the recommendation.
Nonlocal Generalized Models of Predator-Prey Systems
Kuehn, Christian
2011-01-01
The method of generalized modeling has been applied successfully in many different contexts, particularly in ecology and systems biology. It can be used to analyze the stability and bifurcations of steady-state solutions. Although many dynamical systems in mathematical biology exhibit steady-state behaviour one also wants to understand nonlocal dynamics beyond equilibrium points. In this paper we analyze predator-prey dynamical systems and extend the method of generalized models to periodic solutions. First, we adapt the equilibrium generalized modeling approach and compute the unique Floquet multiplier of the periodic solution which depends upon so-called generalized elasticity and scale functions. We prove that these functions also have to satisfy a flow on parameter (or moduli) space. Then we use Fourier analysis to provide computable conditions for stability and the moduli space flow. The final stability analysis reduces to two discrete convolutions which can be interpreted to understand when the predator...
General expression for linear and nonlinear time series models
Institute of Scientific and Technical Information of China (English)
Ren HUANG; Feiyun XU; Ruwen CHEN
2009-01-01
The typical time series models such as ARMA, AR, and MA are founded on the normality and stationarity of a system and expressed by a linear difference equation; therefore, they are strictly limited to the linear system. However, some nonlinear factors are within the practical system; thus, it is difficult to fit the model for real systems with the above models. This paper proposes a general expression for linear and nonlinear auto-regressive time series models (GNAR). With the gradient optimization method and modified AIC information criteria integrated with the prediction error, the parameter estimation and order determination are achieved. The model simulation and experiments show that the GNAR model can accurately approximate to the dynamic characteristics of the most nonlinear models applied in academics and engineering. The modeling and prediction accuracy of the GNAR model is superior to the classical time series models. The proposed GNAR model is flexible and effective.
A Total Generalized Optimal Velocity Model and Its Numerical Tests
Institute of Scientific and Technical Information of China (English)
ZHU Wen-xing; LIU Yun-cai
2008-01-01
A car-following model named total generalized optimal velocity model (TGOVM) was developed with a consideration of an arbitrary number of preceding vehicles before current one based on analyzing the previous models such as optimal velocity model (OVM), generalized OVM (GOVM) and improved GOVM (IGOVM). This model describes the physical phenomena of traffic flow more exactly and realistically than previous models. Also the performance of this model was checked out by simulating the acceleration and de- celeration process for a small delay time. On a single circular lane, the evolution of the traffic congestion was studied for a different number of headways and relative velocities of the preceding vehicles being taken into account. The simulation results show that TGOVM is reasonable and correct.
A generalized trigonometric series function model for determining ionospheric delay
Institute of Scientific and Technical Information of China (English)
YUAN Yunbin; OU Jikun
2004-01-01
A generalized trigonometric series function (GTSF) model, with an adjustable number of parameters, is proposed and analyzed to study ionosphere by using GPS, especially to provide ionospheric delay correction for single frequency GPS users. The preliminary results show that, in comparison with the trigonometric series function (TSF) model and the polynomial (POLY) model, the GTSF model can more precisely describe the ionospheric variation and more efficiently provide the ionospheric correction when GPS data are used to investigate or extract the earth's ionospheric total electron content. It is also shown that the GTSF model can further improve the precision and accuracy of modeling local ionospheric delays.
A generalized hard-sphere model for Monte Carlo simulation
Hassan, H. A.; Hash, David B.
1993-01-01
A new molecular model, called the generalized hard-sphere, or GHS model, is introduced. This model contains, as a special case, the variable hard-sphere model of Bird (1981) and is capable of reproducing all of the analytic viscosity coefficients available in the literature that are derived for a variety of interaction potentials incorporating attraction and repulsion. In addition, a new procedure for determining interaction potentials in a gas mixture is outlined. Expressions needed for implementing the new model in the direct simulation Monte Carlo methods are derived. This development makes it possible to employ interaction models that have the same level of complexity as used in Navier-Stokes calculations.
A generalized item response tree model for psychological assessments.
Jeon, Minjeong; De Boeck, Paul
2016-09-01
A new item response theory (IRT) model with a tree structure has been introduced for modeling item response processes with a tree structure. In this paper, we present a generalized item response tree model with a flexible parametric form, dimensionality, and choice of covariates. The utilities of the model are demonstrated with two applications in psychological assessments for investigating Likert scale item responses and for modeling omitted item responses. The proposed model is estimated with the freely available R package flirt (Jeon et al., 2014b).
A random effects generalized linear model for reliability compositive evaluation
Institute of Scientific and Technical Information of China (English)
无
2009-01-01
This paper first proposes a random effects generalized linear model to evaluate the storage life of one kind of high reliable and small sample-sized products by combining multi-sources information of products coming from the same population but stored at different environments. The relevant algorithms are also provided. Simulation results manifest the soundness and effectiveness of the proposed model.
Bianchi type IX string cosmological model in general relativity
Indian Academy of Sciences (India)
Raj Bali; Shuchi Dave
2001-04-01
We have investigated Bianchi type IX string cosmological models in general relativity. To get a determinate solution, we have assumed a condition ρ= i.e. rest energy density for a cloud of strings is equal to the string tension density. The various physical and geometrical aspects of the models are also discussed.
A general model for matroids and the greedy algorithm
Faigle, U.; Fujishige, Saturo
2009-01-01
We present a general model for set systems to be independence families with respect to set families which determine classes of proper weight functions on a ground set. Within this model, matroids arise from a natural subclass and can be characterized by the optimality of the greedy algorithm. This
General Separations Area (GSA) Groundwater Flow Model Update: Hydrostratigraphic Data
Energy Technology Data Exchange (ETDEWEB)
Bagwell, L. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Bennett, P. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Flach, G. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)
2017-02-21
This document describes the assembly, selection, and interpretation of hydrostratigraphic data for input to an updated groundwater flow model for the General Separations Area (GSA; Figure 1) at the Department of Energy’s (DOE) Savannah River Site (SRS). This report is one of several discrete but interrelated tasks that support development of an updated groundwater model (Bagwell and Flach, 2016).
Applying the General Linear Model to Repeated Measures Problems.
Pohlmann, John T.; McShane, Michael G.
The purpose of this paper is to demonstrate the use of the general linear model (GLM) in problems with repeated measures on a dependent variable. Such problems include pretest-posttest designs, multitrial designs, and groups by trials designs. For each of these designs, a GLM analysis is demonstrated wherein full models are formed and restrictions…
A random effects generalized linear model for reliability compositive evaluation
Institute of Scientific and Technical Information of China (English)
ZHAO Hui; YU Dan
2009-01-01
This paper first proposes a random effects generalized linear model to evaluate the storage life of one kind of high reliable and small sample-sized products by combining multi-sources information of products coming from the same population but stored at different environments.The relevant algorithms are also provided.Simulation results manifest the soundness and effectiveness of the proposed model.
A generalized dynamic conditional correlation model for many asset returns
C.M. Hafner (Christian); Ph.H.B.F. Franses (Philip Hans)
2003-01-01
textabstractIn this paper we put forward a generalization of the Dynamic Conditional Correlation (DCC) Model of Engle (2002). Our model allows for asset-specific correlation sensitivities, which is useful in particular if one aims to summarize a large number of asset returns. The resultant GDCC
A generalized dynamic conditional correlation model for many asset returns
C.M. Hafner (Christian); Ph.H.B.F. Franses (Philip Hans)
2003-01-01
textabstractIn this paper we put forward a generalization of the Dynamic Conditional Correlation (DCC) Model of Engle (2002). Our model allows for asset-specific correlation sensitivities, which is useful in particular if one aims to summarize a large number of asset returns. The resultant GDCC mode
A general model for membrane-based separation processes
DEFF Research Database (Denmark)
Soni, Vipasha; Abildskov, Jens; Jonsson, Gunnar Eigil;
2009-01-01
behaviour will play an important role. In this paper, modelling of membrane-based processes for separation of gas and liquid mixtures are considered. Two general models, one for membrane-based liquid separation processes (with phase change) and another for membrane-based gas separation are presented...
Bayesian Analysis for Binomial Models with Generalized Beta Prior Distributions.
Chen, James J.; Novick, Melvin, R.
1984-01-01
The Libby-Novick class of three-parameter generalized beta distributions is shown to provide a rich class of prior distributions for the binomial model that removes some restrictions of the standard beta class. A numerical example indicates the desirability of using these wider classes of densities for binomial models. (Author/BW)
An applied general equilibrium model for Dutch agribusiness policy analysis.
Peerlings, J.H.M.
1993-01-01
The purpose of this thesis was to develop a basic static applied general equilibrium (AGE) model to analyse the effects of agricultural policy changes on Dutch agribusiness. In particular the effects on inter-industry transactions, factor demand, income, and trade are of interest.The model is fairly
Residuals analysis of the generalized linear models for longitudinal data.
Chang, Y C
2000-05-30
The generalized estimation equation (GEE) method, one of the generalized linear models for longitudinal data, has been used widely in medical research. However, the related sensitivity analysis problem has not been explored intensively. One of the possible reasons for this was due to the correlated structure within the same subject. We showed that the conventional residuals plots for model diagnosis in longitudinal data could mislead a researcher into trusting the fitted model. A non-parametric method, named the Wald-Wolfowitz run test, was proposed to check the residuals plots both quantitatively and graphically. The rationale proposedin this paper is well illustrated with two real clinical studies in Taiwan.
Interaction Strength and a Generalized Bak-Sneppen Evolution Model
Institute of Scientific and Technical Information of China (English)
李炜; 蔡勖
2002-01-01
The Bak-Sneppen evolution model is generalized in terms of a new concept and quantity: interaction strength.Based on a quantitative definition, the interaction strength describes the strength of the interaction between thenearest-neighbour individuals in the model Self-organized criticality is observed for the generalized model withten different values of interaction strength. The gap equation governing the self-organization is derived. It is alsofound that the self-organized threshold depends on the value of the interaction strength.
A general technique to train language models on language models
Nederhof, MJ
2005-01-01
We show that under certain conditions, a language model can be trained oil the basis of a second language model. The main instance of the technique trains a finite automaton on the basis of a probabilistic context-free grammar, such that the Kullback-Leibler distance between grammar and trained auto
Shouldice, Heather Nelson
2017-01-01
Few entering music education students plan to teach in an elementary general music (EGM) setting, and the majority of those who teach EGM are female and have vocalist backgrounds. The purpose of this collective case study was to examine six male instrumentalists' decisions to pursue a career in EGM teaching rather than secondary instrumental…
QCD Sum Rules and Models for Generalized Parton Distributions
Energy Technology Data Exchange (ETDEWEB)
Anatoly Radyushkin
2004-10-01
I use QCD sum rule ideas to construct models for generalized parton distributions. To this end, the perturbative parts of QCD sum rules for the pion and nucleon electromagnetic form factors are interpreted in terms of GPDs and two models are discussed. One of them takes the double Borel transform at adjusted value of the Borel parameter as a model for nonforward parton densities, and another is based on the local duality relation. Possible ways of improving these Ansaetze are briefly discussed.
Yoshizawa, Katsuhiko; Yuki, Michiko; Kinoshita, Yuichi; Emoto, Yuko; Yuri, Takashi; Shikata, Nobuaki; Elmore, Susan A; Tsubura, Airo
2016-05-01
The frequency of breast cancer in men is extremely rare, reported to be less than 1% and there is currently no available animal model for male mammary tumors. We compared the characteristics of various immunohistochemical markers in N-methyl-N-nitrosourea (MNU)-induced mammary adenocarcinomas in male and female Crj:CD(SD)IGS rats including: estrogen receptor α (ER), progesterone receptor (PgR), androgen receptor (AR), receptor tyrosine-protein kinase erbB-2 (HER2), GATA binding protein 3 (GATA3), and proliferating cell nuclear antigen (PCNA). Female mammary adenocarcinomas were strongly positive in the nuclei of tumor cells for PCNA and ER (100%) with only 60% and 53% expressing PgR and GATA3, respectively. 100% of male adenocarcinomas also exhibited strongly positive expression in the nuclei of tumor cells for PCNA, with 25% expressing AR and only 8% showing positivity for ER. Male carcinomas did not express PgR or GATA3 and none of the tumors, male or female, were positive for HER2. Based on the observed ER and PgR positivity and HER2 negativity within these tumors, MNU-induced mammary adenocarcinomas in female rats appear to be hormonally dependent, similar to human luminal A type breast cancer. In contrast, MNU-induced mammary adenocarcinomas in male rats showed no reactivity for ER, PgR, HER2 or GATA3, suggesting no hormonal dependency. Both male and female adenocarcinomas showed high proliferating activity by PCNA immunohistochemistry. Based on our literature review, human male breast cancers are mainly dependent on ER and/or PgR, therefore the biological pathogenesis of MNU-induced male mammary cancer in rats may differ from that of male breast cancer in humans.
Modeling the suppression of sea lamprey populations by use of the male sex pheromone
Klassen, Waldemar; Adams, Jean V.; Twohey, Michael B.
2005-01-01
The suppression of sea lamprey populations, Petromyzon marinus (Linnaeus), was modeled using four different applications of the male sex pheromone: (1) pheromone-baited traps that remove females from the spawning population, (2) pheromone-baited decoys that exhaust females before they are able to spawn, (3) pheromone-enhanced sterile males that increase the proportion of non-fertile matings, and (4) camouflaging of the pheromone emitted by calling males to make it difficult for females to find a mate. The models indicated that thousands of traps or hundreds of thousands of decoys would be required to suppress a population of 100,000 animals. The potential efficacy of pheromone camouflages is largely unknown, and additional research is required to estimate how much pheromone is needed to camouflage the pheromone plumes of calling males. Pheromone-enhanced sterile males appear to be a promising application in the Great Lakes. Using this technique for three generations each of ca. 7 years duration could reduce sea lamprey populations by 90% for Lakes Huron and Ontario and by 98% for Lake Michigan, based on current trapping operations that capture 20 to 30% of the population each year.
Biomimetic agent based modelling using male Frog calling behaviour as a case study
DEFF Research Database (Denmark)
Jørgensen, Søren V.; Demazeau, Yves; Christensen-Dalsgaard, Jakob;
2014-01-01
A new agent-based modelling tool has been developed to allow the modelling of populations of individuals whose interactions are characterised by tightly timed dynamics. The tool was developed to model male frog calling dynamics, to facilitate research into what local rules may be employed...... Frog, E. coqui, is implemented as a case study for the presentation and discussion of the tool, and results from this model are presented. RANA, in its present stage of development, is shown to be able to handle the problem of modelling calling frogs, and several fruitful extensions are proposed...
Alci, Bulent
2015-01-01
This study aims to determine the predictive and explanatory model in terms of university students' academic performance in "General Chemistry" course and their motivational features. The participants were 169 university students in the 1st grade at university. Of the participants, 132 were female and 37 were male students. Regarding…
Alci, Bulent
2015-01-01
This study aims to determine the predictive and explanatory model in terms of university students' academic performance in "General Chemistry" course and their motivational features. The participants were 169 university students in the 1st grade at university. Of the participants, 132 were female and 37 were male students. Regarding…
Male sex aggravates the phenotype in mouse models of hypertrophic cardiomyopathy
Maass, AH; Maier, SKG
2005-01-01
The authors have created transgenic mouse models of hypertrophic cardiomyopathy with mutations in either cardiac troponin T or myosin heavy chain. Mice mutant in myosin heavy chain develop significant cardiac hypertrophy at young adult age. Female mice keep that hypertrophic state, whereas male mice
Male sex aggravates the phenotype in mouse models of hypertrophic cardiomyopathy
Maass, AH; Maier, SKG
2005-01-01
The authors have created transgenic mouse models of hypertrophic cardiomyopathy with mutations in either cardiac troponin T or myosin heavy chain. Mice mutant in myosin heavy chain develop significant cardiac hypertrophy at young adult age. Female mice keep that hypertrophic state, whereas male mice
General Linear Models: An Integrated Approach to Statistics
Directory of Open Access Journals (Sweden)
Andrew Faulkner
2008-09-01
Full Text Available Generally, in psychology, the various statistical analyses are taught independently from each other. As a consequence, students struggle to learn new statistical analyses, in contexts that differ from their textbooks. This paper gives a short introduction to the general linear model (GLM, in which it is showed that ANOVA (one-way, factorial, repeated measure and analysis of covariance is simply a multiple correlation/regression analysis (MCRA. Generalizations to other cases, such as multivariate and nonlinear analysis, are also discussed. It can easily be shown that every popular linear analysis can be derived from understanding MCRA.
Blind source separation based on generalized gaussian model
Institute of Scientific and Technical Information of China (English)
YANG Bin; KONG Wei; ZHOU Yue
2007-01-01
Since in most blind source separation (BSS) algorithms the estimations of probability density function (pdf) of sources are fixed or can only switch between one sup-Gaussian and other sub-Gaussian model,they may not be efficient to separate sources with different distributions. So to solve the problem of pdf mismatch and the separation of hybrid mixture in BSS, the generalized Gaussian model (GGM) is introduced to model the pdf of the sources since it can provide a general structure of univariate distributions. Its great advantage is that only one parameter needs to be determined in modeling the pdf of different sources, so it is less complex than Gaussian mixture model. By using maximum likelihood (ML) approach, the convergence of the proposed algorithm is improved. The computer simulations show that it is more efficient and valid than conventional methods with fixed pdf estimation.
Modeling the brain morphology distribution in the general aging population
Huizinga, W.; Poot, D. H. J.; Roshchupkin, G.; Bron, E. E.; Ikram, M. A.; Vernooij, M. W.; Rueckert, D.; Niessen, W. J.; Klein, S.
2016-03-01
Both normal aging and neurodegenerative diseases such as Alzheimer's disease cause morphological changes of the brain. To better distinguish between normal and abnormal cases, it is necessary to model changes in brain morphology owing to normal aging. To this end, we developed a method for analyzing and visualizing these changes for the entire brain morphology distribution in the general aging population. The method is applied to 1000 subjects from a large population imaging study in the elderly, from which 900 were used to train the model and 100 were used for testing. The results of the 100 test subjects show that the model generalizes to subjects outside the model population. Smooth percentile curves showing the brain morphology changes as a function of age and spatiotemporal atlases derived from the model population are publicly available via an interactive web application at agingbrain.bigr.nl.
A general diagnostic model applied to language testing data.
von Davier, Matthias
2008-11-01
Probabilistic models with one or more latent variables are designed to report on a corresponding number of skills or cognitive attributes. Multidimensional skill profiles offer additional information beyond what a single test score can provide, if the reported skills can be identified and distinguished reliably. Many recent approaches to skill profile models are limited to dichotomous data and have made use of computationally intensive estimation methods such as Markov chain Monte Carlo, since standard maximum likelihood (ML) estimation techniques were deemed infeasible. This paper presents a general diagnostic model (GDM) that can be estimated with standard ML techniques and applies to polytomous response variables as well as to skills with two or more proficiency levels. The paper uses one member of a larger class of diagnostic models, a compensatory diagnostic model for dichotomous and partial credit data. Many well-known models, such as univariate and multivariate versions of the Rasch model and the two-parameter logistic item response theory model, the generalized partial credit model, as well as a variety of skill profile models, are special cases of this GDM. In addition to an introduction to this model, the paper presents a parameter recovery study using simulated data and an application to real data from the field test for TOEFL Internet-based testing.
Modelling dynamic programming problems by generalized d-graphs
Kátai, Zoltán
2010-01-01
In this paper we introduce the concept of generalized d-graph (admitting cycles) as special dependency-graphs for modelling dynamic programming (DP) problems. We describe the d-graph versions of three famous single-source shortest algorithms (The algorithm based on the topological order of the vertices, Dijkstra algorithm and Bellman-Ford algorithm), which can be viewed as general DP strategies in the case of three different class of optimization problems. The new modelling method also makes possible to classify DP problems and the corresponding DP strategies in term of graph theory.
GEMFsim: A Stochastic Simulator for the Generalized Epidemic Modeling Framework
Sahneh, Faryad Darabi; Shakeri, Heman; Fan, Futing; Scoglio, Caterina
2016-01-01
The recently proposed generalized epidemic modeling framework (GEMF) \\cite{sahneh2013generalized} lays the groundwork for systematically constructing a broad spectrum of stochastic spreading processes over complex networks. This article builds an algorithm for exact, continuous-time numerical simulation of GEMF-based processes. Moreover the implementation of this algorithm, GEMFsim, is available in popular scientific programming platforms such as MATLAB, R, Python, and C; GEMFsim facilitates simulating stochastic spreading models that fit in GEMF framework. Using these simulations one can examine the accuracy of mean-field-type approximations that are commonly used for analytical study of spreading processes on complex networks.
Dynamic generalized linear models for monitoring endemic diseases
DEFF Research Database (Denmark)
Lopes Antunes, Ana Carolina; Jensen, Dan Børge; Halasa, T.
The objective was to use a Dynamic Generalized Linear Model (DGLM) based on abinomial distribution with a linear trend, for monitoring the PRRS (Porcine Reproductive and Respiratory Syndrome sero-prevalence in Danish swine herds. The DGLM was described and its performance for monitoring control...... in sero-prevalence. Based on this, it was possible to detect variations in the growth model component. This study is a proof-of-concept, demonstrating the use of DGLMs for monitoring endemic diseases. In addition, the principles stated might be useful in general research on monitoring and surveillance...
Directory of Open Access Journals (Sweden)
IRNANDA AIKO FIFI DJUUNA
2010-07-01
Full Text Available Djuuna IAF, Abbott LK, Van Niel K (2010 Predicting infectivity of Arbuscular Mycorrhizal fungi from soil variables using Generalized Additive Models and Generalized Linear Models. Biodiversitas 11: 145-150. The objective of this study was to predict the infectivity of arbuscular mycorrhizal fungi (AM fungi, from field soil based on soil properties and land use history using generalized additive models (GAMs and generalized linear models (GLMs. A total of 291 soil samples from a farm in Western Australia near Wickepin were collected and used in this study. Nine soil properties, including elevation, pH, EC, total C, total N, P, K, microbial biomass carbon, and soil texture, and land use history of the farm were used as independent variables, while the percentage of root length colonized (%RLC was used as the dependent variable. GAMs parameterized for the percent of root length colonized suggested skewed quadratic responses to soil pH and microbial biomass carbon; cubic responses to elevation and soil K; and linear responses to soil P, EC and total C. The strength of the relationship between percent root length colonized by AM fungi and environmental variables showed that only elevation, total C and microbial biomass carbon had strong relationships. In general, GAMs and GLMs models confirmed the strong relationship between infectivity of AM fungi (assessed in a glasshouse bioassay for soil collected in summer prior to the first rain of the season and soil properties.
Coexistence of Interacting Opinions in a Generalized Sznajd Model
Timpanaro, André M
2011-01-01
The Sznajd model is a sociophysics model that mimics the propagation of opinions in a closed society, where the interactions favour groups of agreeing people. It is based in the Ising and Potts ferromagnetic models and although the original model used only linear chains, it has since been adapted to general networks. This model has a very rich transient, that has been used to model several aspects of elections, but its stationary states are always consensus states. In order to model more complex behaviours we have, in a recent work, introduced the idea of biases and prejudices to the Sznajd model, by generalizing the bounded confidence rule that is common to many continuous opinion models. In that work we have found that the mean-field version of this model (corresponding to a complete network) allows for stationary states where non-interacting opinions survive, but never for the coexistence of interacting opinions. In the present work, we provide networks that allow for the coexistence of interacting opinion...
Janssen, Paddy K.C.
2016-01-01
Purpose To find the most accurate mathematical description of the intravaginal ejaculation latency time (IELT) distribution in the general male population. Materials and Methods We compared the fitness of various well-known mathematical distributions with the IELT distribution of two previously published stopwatch studies of the Caucasian general male population and a stopwatch study of Dutch Caucasian men with lifelong premature ejaculation (PE). The accuracy of fitness is expressed by the Goodness of Fit (GOF). The smaller the GOF, the more accurate is the fitness. Results The 3 IELT distributions are gamma distributions, but the IELT distribution of lifelong PE is another gamma distribution than the IELT distribution of men in the general male population. The Lognormal distribution of the gamma distributions most accurately fits the IELT distribution of 965 men in the general population, with a GOF of 0.057. The Gumbel Max distribution most accurately fits the IELT distribution of 110 men with lifelong PE with a GOF of 0.179. There are more men with lifelong PE ejaculating within 30 and 60 seconds than can be extrapolated from the probability density curve of the Lognormal IELT distribution of men in the general population. Conclusions Men with lifelong PE have a distinct IELT distribution, e.g., a Gumbel Max IELT distribution, that can only be retrieved from the general male population Lognormal IELT distribution when thousands of men would participate in a IELT stopwatch study. The mathematical formula of the Lognormal IELT distribution is useful for epidemiological research of the IELT. PMID:26981594
Directory of Open Access Journals (Sweden)
Gabriel Alejandro Bonaterra
Full Text Available Fibromyalgia (FM is a chronic musculoskeletal pain disorder, characterized by chronic widespread pain and bodily tenderness and is often accompanied by affective disturbances, however often with unknown etiology. According to recent reports, physical and psychological stress trigger FM. To develop new treatments for FM, experimental animal models for FM are needed to be development and characterized. Using a mouse model for FM including intermittent cold stress (ICS, we hypothesized that ICS leads to morphological alterations in skeletal muscles in mice.Male and female ICS mice were kept under alternating temperature (4 °C/room temperature [22 °C]; mice constantly kept at room temperature served as control. After scarification, gastrocnemius and soleus muscles were removed and snap-frozen in liquid nitrogen-cooled isopentane or fixed for electron microscopy.In gastrocnemius/soleus muscles of male ICS mice, we found a 21.6% and 33.2% decrease of fiber cross sectional area (FCSA, which in soleus muscle concerns the loss of type IIa and IIx FCSA. This phenomenon was not seen in muscles of female ICS mice. However, this loss in male ICS mice was associated with an increase in gastrocnemius of the density of MIF+ (8.6%-, MuRF+ (14.7%-, Fbxo32+ (17.8%-cells, a 12.1% loss of capillary contacts/muscle fiber as well as a 30.7% increase of damaged mitochondria in comparison with male control mice. Moreover, significant positive correlations exist among densities (n/mm(2 of MIF+, MuRF+, Fbxo32+-cells in gastrocnemius/ soleus muscles of male ICS mice; these cell densities inversely correlate with FCSA especially in gastrocnemius muscle of male ICS mice.The ICS-induced decrease of FCSA mainly concerns gastrocnemius muscle of male mice due to an increase of inflammatory and atrogenic cells. In soleus muscle of male ICS and soleus/gastrocnemius muscles of female ICS mice morphological alterations seem to occur not at all or delayed. The sex-specificity of
Oezel, Lisa; Schwarzbach, Hans; Ocker, Matthias; Thieme, Kati; Di Fazio, Pietro; Kinscherf, Ralf
2016-01-01
Background Fibromyalgia (FM) is a chronic musculoskeletal pain disorder, characterized by chronic widespread pain and bodily tenderness and is often accompanied by affective disturbances, however often with unknown etiology. According to recent reports, physical and psychological stress trigger FM. To develop new treatments for FM, experimental animal models for FM are needed to be development and characterized. Using a mouse model for FM including intermittent cold stress (ICS), we hypothesized that ICS leads to morphological alterations in skeletal muscles in mice. Methods Male and female ICS mice were kept under alternating temperature (4°C/room temperature [22°C]); mice constantly kept at room temperature served as control. After scarification, gastrocnemius and soleus muscles were removed and snap-frozen in liquid nitrogen–cooled isopentane or fixed for electron microscopy. Results In gastrocnemius/soleus muscles of male ICS mice, we found a 21.6% and 33.2% decrease of fiber cross sectional area (FCSA), which in soleus muscle concerns the loss of type IIa and IIx FCSA. This phenomenon was not seen in muscles of female ICS mice. However, this loss in male ICS mice was associated with an increase in gastrocnemius of the density of MIF+ (8.6%)-, MuRF+ (14.7%)-, Fbxo32+ (17.8%)-cells, a 12.1% loss of capillary contacts/muscle fiber as well as a 30.7% increase of damaged mitochondria in comparison with male control mice. Moreover, significant positive correlations exist among densities (n/mm2) of MIF+, MuRF+, Fbxo32+-cells in gastrocnemius/ soleus muscles of male ICS mice; these cell densities inversely correlate with FCSA especially in gastrocnemius muscle of male ICS mice. Conclusion The ICS-induced decrease of FCSA mainly concerns gastrocnemius muscle of male mice due to an increase of inflammatory and atrogenic cells. In soleus muscle of male ICS and soleus/gastrocnemius muscles of female ICS mice morphological alterations seem to occur not at all or
Generalized memory associativity in a network model for the neuroses
Wedemann, Roseli S.; Donangelo, Raul; de Carvalho, Luís A. V.
2009-03-01
We review concepts introduced in earlier work, where a neural network mechanism describes some mental processes in neurotic pathology and psychoanalytic working-through, as associative memory functioning, according to the findings of Freud. We developed a complex network model, where modules corresponding to sensorial and symbolic memories interact, representing unconscious and conscious mental processes. The model illustrates Freud's idea that consciousness is related to symbolic and linguistic memory activity in the brain. We have introduced a generalization of the Boltzmann machine to model memory associativity. Model behavior is illustrated with simulations and some of its properties are analyzed with methods from statistical mechanics.
Vortices in generalized Abelian Chern-Simons-Higgs model
Casana, Rodolfo
2015-01-01
We study a generalization of abelian Chern-Simons-Higgs model by introducing nonstandard kinetic terms. We will obtain a generic form of Bogomolnyi equations by minimizing the energy functional of the model. This generic form of Bogomolnyi equations produce an infinity number of soliton solutions. As a particular limit of these generic Bogomolnyi equations, we obtain the Bogomolnyi equations of the abelian Maxwell-Higgs model and the abelian Chern-Simons Higgs model. Finally, novel soliton solutions emerge from these generic Bogomolnyi equations. We analyze these solutions from theoretical and numerical point of view.
Observational constraints on the generalized $\\alpha$ attractor model
Shahalam, M; Myrzakul, Shynaray; Wang, Anzhong
2016-01-01
We study the generalized $\\alpha$ attractor model in context of late time cosmic acceleration; the model interpolates between freezing and thawing dark energy models. In the slow roll regime, the originally potential is modified whereas the modification ceases in the asymptotic regime and the effective potential behaves as quadratic. In our setting, field rolls slowly around the present epoch and mimics dark matter in future. We put observational constraints on the model parameters for which we use an integrated data base (SN+Hubble+BAO+CMB) for carrying out the data analysis.
Generalized memory associativity in a network model for the neuroses.
Wedemann, Roseli S; Donangelo, Raul; de Carvalho, Luís A V
2009-03-01
We review concepts introduced in earlier work, where a neural network mechanism describes some mental processes in neurotic pathology and psychoanalytic working-through, as associative memory functioning, according to the findings of Freud. We developed a complex network model, where modules corresponding to sensorial and symbolic memories interact, representing unconscious and conscious mental processes. The model illustrates Freud's idea that consciousness is related to symbolic and linguistic memory activity in the brain. We have introduced a generalization of the Boltzmann machine to model memory associativity. Model behavior is illustrated with simulations and some of its properties are analyzed with methods from statistical mechanics.
Generalized F test and generalized deviance test in two-way ANOVA models for randomized trials.
Shen, Juan; He, Xuming
2014-01-01
We consider the problem of detecting treatment effects in a randomized trial in the presence of an additional covariate. By reexpressing a two-way analysis of variance (ANOVA) model in a logistic regression framework, we derive generalized F tests and generalized deviance tests, which provide better power in detecting common location-scale changes of treatment outcomes than the classical F test. The null distributions of the test statistics are independent of the nuisance parameters in the models, so the critical values can be easily determined by Monte Carlo methods. We use simulation studies to demonstrate how the proposed tests perform compared with the classical F test. We also use data from a clinical study to illustrate possible savings in sample sizes.
Biomimetic agent based modelling using male Frog calling behaviour as a case study
DEFF Research Database (Denmark)
Jørgensen, Søren V.; Demazeau, Yves; Christensen-Dalsgaard, Jakob
2014-01-01
by individuals to generate their observed population behaviour. A number of existing agent-modelling frameworks are considered, but none have the ability to handle large numbers of time-dependent event-generating agents; hence the construction of a new tool, RANA. The calling behaviour of the Puerto Rican Tree......A new agent-based modelling tool has been developed to allow the modelling of populations of individuals whose interactions are characterised by tightly timed dynamics. The tool was developed to model male frog calling dynamics, to facilitate research into what local rules may be employed...
Practical likelihood analysis for spatial generalized linear mixed models
DEFF Research Database (Denmark)
Bonat, W. H.; Ribeiro, Paulo Justiniano
2016-01-01
We investigate an algorithm for maximum likelihood estimation of spatial generalized linear mixed models based on the Laplace approximation. We compare our algorithm with a set of alternative approaches for two datasets from the literature. The Rhizoctonia root rot and the Rongelap are, respectiv......We investigate an algorithm for maximum likelihood estimation of spatial generalized linear mixed models based on the Laplace approximation. We compare our algorithm with a set of alternative approaches for two datasets from the literature. The Rhizoctonia root rot and the Rongelap are...... of Laplace approximation include the computation of the maximized log-likelihood value, which can be used for model selection and tests, and the possibility to obtain realistic confidence intervals for model parameters based on profile likelihoods. The Laplace approximation also avoids the tuning...
Automation of electroweak NLO corrections in general models
Energy Technology Data Exchange (ETDEWEB)
Lang, Jean-Nicolas [Universitaet Wuerzburg (Germany)
2016-07-01
I discuss the automation of generation of scattering amplitudes in general quantum field theories at next-to-leading order in perturbation theory. The work is based on Recola, a highly efficient one-loop amplitude generator for the Standard Model, which I have extended so that it can deal with general quantum field theories. Internally, Recola computes off-shell currents and for new models new rules for off-shell currents emerge which are derived from the Feynman rules. My work relies on the UFO format which can be obtained by a suited model builder, e.g. FeynRules. I have developed tools to derive the necessary counterterm structures and to perform the renormalization within Recola in an automated way. I describe the procedure using the example of the two-Higgs-doublet model.
Improved Generalized Force Model considering the Comfortable Driving Behavior
Directory of Open Access Journals (Sweden)
De-Jie Xu
2015-01-01
Full Text Available This paper presents an improved generalized force model (IGFM that considers the driver’s comfortable driving behavior. Through theoretical analysis, we propose the calculation methods of comfortable driving distance and velocity. Then the stability condition of the model is obtained by the linear stability analysis. The problems of the unrealistic acceleration of the leading car existing in the previous models were solved. Furthermore, the simulation results show that IGFM can predict correct delay time of car motion and kinematic wave speed at jam density, and it can exactly describe the driver’s behavior under an urgent case, where no collision occurs. The dynamic properties of IGFM also indicate that stability has improved compared to the generalized force model.
Beyond the mouse monopoly: studying the male germ line in domestic animal models.
González, Raquel; Dobrinski, Ina
2015-01-01
Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis and essential to maintain the continuous production of spermatozoa after the onset of puberty in the male. The study of the male germ line is important for understanding the process of spermatogenesis, unravelling mechanisms of stemness maintenance, cell differentiation, and cell-to-cell interactions. The transplantation of SSCs can contribute to the preservation of the genome of valuable individuals in assisted reproduction programs. In addition to the importance of SSCs for male fertility, their study has recently stimulated interest in the generation of genetically modified animals because manipulations of the male germ line at the SSC stage will be maintained in the long term and transmitted to the offspring. Studies performed mainly in the mouse model have laid the groundwork for facilitating advancements in the field of male germ line biology, but more progress is needed in nonrodent species in order to translate the technology to the agricultural and biomedical fields. The lack of reliable markers for isolating germ cells from testicular somatic cells and the lack of knowledge of the requirements for germ cell maintenance have precluded their long-term maintenance in domestic animals. Nevertheless, some progress has been made. In this review, we will focus on the state of the art in the isolation, characterization, culture, and manipulation of SSCs and the use of germ cell transplantation in domestic animals.
MODELING FOR DEMOGRAPHIC AND REGIONAL PREVALENCE AND TRENDS OF SMOKING IN THAI MALES.
Lim, Apiradee; McNeil, Don
2016-03-01
This study aimed to describe using national survey data the demographic and regional prevalence and trends of smoking in Thai males during the past 25 years. Data from eight national surveys conducted by the National Statistics Office from 1986 to 2011 were used to examine the prevalence of smoking. Males aged 15 and older were included in this study. Logistic regression was used to model smoking patterns, according to year of survey, age group, urbanization, and Public Health Area (PHA). The prevalence of smoking among males aged 15 years and older in 2011 was 38.4%. Sharply increasing smoking prevalence was found in the 15-24 years-old age group in all surveys. Before survey year 1999, the prevalence of smoking started to level off near retirement age, and subsequently, it leveled off after 40 years of age. The prevalence of smoking in all age groups decreased after 1986 except in the 15-19 years-old age group. Higher prevalence of smoking was found in rural areas. Males from the Northeast and the lower South regions had the highest prevalence. More effective anti-smoking policies should focus on males aged below 25 years to reduce the increasing prevalence of smoking in this group.
Directory of Open Access Journals (Sweden)
Matthew Westercamp
Full Text Available Using a population-based survey we examined the behaviors, beliefs, and HIV/HSV-2 serostatus of men and women in the traditionally non-circumcising community of Kisumu, Kenya prior to establishment of voluntary medical male circumcision services. A total of 749 men and 906 women participated. Circumcision status was not associated with HIV/HSV-2 infection nor increased high risk sexual behaviors. In males, preference for being or becoming circumcised was associated with inconsistent condom use and increased lifetime number of sexual partners. Preference for circumcision was increased with understanding that circumcised men are less likely to become infected with HIV.
SELECTION MOMENTS AND GENERALIZED METHOD OF MOMENTS FOR HETEROSKEDASTIC MODELS
Directory of Open Access Journals (Sweden)
Constantin ANGHELACHE
2016-06-01
Full Text Available In this paper, the authors describe the selection methods for moments and the application of the generalized moments method for the heteroskedastic models. The utility of GMM estimators is found in the study of the financial market models. The selection criteria for moments are applied for the efficient estimation of GMM for univariate time series with martingale difference errors, similar to those studied so far by Kuersteiner.
General Model for Infrastructure Multi-channel Wireless LANs
Fayez Gebali; Abdelsalam Amer
2010-01-01
In this paper we develop an integrated model for request mechanism and data transmission in multi-channel wireless local area networks. We calculated the performance parameters for single and multi-channel wireless networks when the channel is noisy. The proposed model is general it can be applied to different wireless networks such as IEEE802.11x, IEEE802.16, CDMA operated networks and Hiperlan\\2.
Development of the Model of the Generalized Quintom Dark Energy
Institute of Scientific and Technical Information of China (English)
WANG Wei; GUI Yuan-Xing; SHAO Ying
2006-01-01
@@ We consider a generalized quintom (GQ) dark energy modelfor changing the equal weight of the negative-kinetic scalar field (phantom) and the normal scalar field (quintessence) in quintom dark energy. Though the phantomdominated scaling solution is a stable late-time attractor, the early evolution of GQ is different from that of the quintom model and the adjustability of the dark energy state equation in the model is improved.
The direction of migration: a dynamic general equilibrium model.
Lee, K S
1984-11-01
A two-sector dynamic general equilibrium model is developed "to investigate the direction of migration in response to differing demographic and consumption demand behavior, as well as variations in production conditions." The model, which involves a rural sector and an urban sector, incorporates "returns to scale and the natural rate of sectoral population growth as important determinants of the direction of migration, in addition to price and income elasticities, and the sectoral technical change rate with which...previous studies dealt."
Bianchi type-V string cosmological models in general relativity
Indian Academy of Sciences (India)
Anil Kumar Yadav; Vineet Kumar Yadav; Lallan Yadav
2011-04-01
Bianchi type-V string cosmological models in general relativity are investigated. To get the exact solution of Einstein’s ﬁeld equations, we have taken some scale transformations used by Camci et al [Astrophys. Space Sci. 275, 391 (2001)]. It is shown that Einstein’s ﬁeld equations are solvable for any arbitrary cosmic scale function. Solutions for particular forms of cosmic scale functions are also obtained. Some physical and geometrical aspects of the models are discussed.
Estimation linear model using block generalized inverse of a matrix
Jasińska, Elżbieta; Preweda, Edward
2013-01-01
The work shows the principle of generalized linear model, point estimation, which can be used as a basis for determining the status of movements and deformations of engineering objects. The structural model can be put on any boundary conditions, for example, to ensure the continuity of the deformations. Estimation by the method of least squares was carried out taking into account the terms and conditions of the Gauss- Markov for quadratic forms stored using Lagrange function. The original sol...
Directory of Open Access Journals (Sweden)
Qinghua Xie
2017-01-01
Full Text Available Recently, a general polarimetric model-based decomposition framework was proposed by Chen et al., which addresses several well-known limitations in previous decomposition methods and implements a simultaneous full-parameter inversion by using complete polarimetric information. However, it only employs four typical models to characterize the volume scattering component, which limits the parameter inversion performance. To overcome this issue, this paper presents two general polarimetric model-based decomposition methods by incorporating the generalized volume scattering model (GVSM or simplified adaptive volume scattering model, (SAVSM proposed by Antropov et al. and Huang et al., respectively, into the general decomposition framework proposed by Chen et al. By doing so, the final volume coherency matrix structure is selected from a wide range of volume scattering models within a continuous interval according to the data itself without adding unknowns. Moreover, the new approaches rely on one nonlinear optimization stage instead of four as in the previous method proposed by Chen et al. In addition, the parameter inversion procedure adopts the modified algorithm proposed by Xie et al. which leads to higher accuracy and more physically reliable output parameters. A number of Monte Carlo simulations of polarimetric synthetic aperture radar (PolSAR data are carried out and show that the proposed method with GVSM yields an overall improvement in the final accuracy of estimated parameters and outperforms both the version using SAVSM and the original approach. In addition, C-band Radarsat-2 and L-band AIRSAR fully polarimetric images over the San Francisco region are also used for testing purposes. A detailed comparison and analysis of decomposition results over different land-cover types are conducted. According to this study, the use of general decomposition models leads to a more accurate quantitative retrieval of target parameters. However, there
Computerized Classification Testing under the Generalized Graded Unfolding Model
Wang, Wen-Chung; Liu, Chen-Wei
2011-01-01
The generalized graded unfolding model (GGUM) has been recently developed to describe item responses to Likert items (agree-disagree) in attitude measurement. In this study, the authors (a) developed two item selection methods in computerized classification testing under the GGUM, the current estimate/ability confidence interval method and the cut…
Suggesting a General ESP Model for Adult Learners
Al-Jumaily, Samir
2011-01-01
The study suggests a general model that could guarantee the cooperation between teachers and their students to overcome the difficulties encountered in ESP learning. It tries to join together different perspectives in the research of adult education, specifically in the teaching of English for Specific Purposes. It also provides some sort of trust…
Anisotropic cosmological models and generalized scalar tensor theory
Indian Academy of Sciences (India)
Subenoy Chakraborty; Batul Chandra Santra; Nabajit Chakravarty
2003-10-01
In this paper generalized scalar tensor theory has been considered in the background of anisotropic cosmological models, namely, axially symmetric Bianchi-I, Bianchi-III and Kortowski–Sachs space-time. For bulk viscous ﬂuid, both exponential and power-law solutions have been studied and some assumptions among the physical parameters and solutions have been discussed.
A general circulation model (GCM) parameterization of Pinatubo aerosols
Energy Technology Data Exchange (ETDEWEB)
Lacis, A.A.; Carlson, B.E.; Mishchenko, M.I. [NASA Goddard Institute for Space Studies, New York, NY (United States)
1996-04-01
The June 1991 volcanic eruption of Mt. Pinatubo is the largest and best documented global climate forcing experiment in recorded history. The time development and geographical dispersion of the aerosol has been closely monitored and sampled. Based on preliminary estimates of the Pinatubo aerosol loading, general circulation model predictions of the impact on global climate have been made.
RF Circuit linearity optimization using a general weak nonlinearity model
Cheng, W.; Oude Alink, M.S.; Annema, Anne J.; Croon, Jeroen A.; Nauta, Bram
2012-01-01
This paper focuses on optimizing the linearity in known RF circuits, by exploring the circuit design space that is usually available in today’s deep submicron CMOS technologies. Instead of using brute force numerical optimizers we apply a generalized weak nonlinearity model that only involves AC
An applied general equilibrium model for Dutch agribusiness policy analysis
Peerlings, J.
1993-01-01
The purpose of this thesis was to develop a basic static applied general equilibrium (AGE) model to analyse the effects of agricultural policy changes on Dutch agribusiness. In particular the effects on inter-industry transactions, factor demand, income, and trade are of interest.
[General systems theory, analog models and essential arterial hypertension].
Indovina, I; Bonelli, M
1991-02-15
The application of the General System Theory to the fields of biology and particularly of medicine is fraught with many difficulties deriving from the mathematical complexities of application. The authors suggest that these difficulties can be overcome by applying analogical models, thus opening new prospects for the resolution of the manifold problems involved in connection with the study of arterial hypertension.
An applied general equilibrium model for Dutch agribusiness policy analysis
Peerlings, J.
1993-01-01
The purpose of this thesis was to develop a basic static applied general equilibrium (AGE) model to analyse the effects of agricultural policy changes on Dutch agribusiness. In particular the effects on inter-industry transactions, factor demand, income, and trade are of
Sharing Rule Identification for General Collective Consumption Models
Cherchye, L.J.H.; de Rock, B.; Lewbel, A.; Vermeulen, F.M.P.
2012-01-01
Abstract: We propose a method to identify bounds (i.e. set identification) on the sharing rule for a general collective household consumption model. Unlike the effects of distribution factors, it is well known that the level of the sharing rule cannot be uniquely identified without strong assumption
Suggesting a General ESP Model for Adult Learners
Al-Jumaily, Samir
2011-01-01
The study suggests a general model that could guarantee the cooperation between teachers and their students to overcome the difficulties encountered in ESP learning. It tries to join together different perspectives in the research of adult education, specifically in the teaching of English for Specific Purposes. It also provides some sort of trust…
Directory of Open Access Journals (Sweden)
Faisal Abdi Matondang
2014-06-01
Conclusions: Our study provides evidence that the management of male LUTS suggestive of BPH by GPs in Jakarta suggests referral in part to available guidelines in terms of diagnostic methods and initial therapy. However, several aspects of the guidelines, such as PSA level measurement, renal function assessment, urinalysis, ultrasound examination, and prescription of combination therapies, are still infrequently performed.
The effect of antineoplastic drugs in a male spontaneous mammary tumor model.
Directory of Open Access Journals (Sweden)
Stephanie N Shishido
Full Text Available Male breast cancer is a rare disease. The limited number of clinical cases has led to the primary treatments for men being derived from female breast cancer studies. Here the transgenic strain FVB/N-Tg(MMTV-PyVT634Mul/J (also known as PyVT was used as a model system for measuring tumor burden and drug sensitivity of the antineoplastic drugs tamoxifen, cisplatin, and paclitaxel on tumorigenesis at an early stage of mammary carcinoma development in a male mouse model. Cisplatin treatment significantly reduced tumor volume, while paclitaxel and tamoxifen did not attenuate tumor growth. Cisplatin treatment was shown to induce apoptosis, grossly observed by reduced tumor formation, through reduced Bcl-2 and survivin protein expression levels with an increase in caspase 3 expression compared to control tumors. Tamoxifen treatment significantly altered the hormone receptor expression levels of the tumor, while additionally upregulating Bcl-2 and Cyclin D1. This suggests an importance in hormonal signaling in male breast cancer pathogenesis. The results of this study provide valuable information toward the better understanding of male breast cancer and may help guide treatment decisions.
Estimation of Phylogeny Using a General Markov Model
Directory of Open Access Journals (Sweden)
John Robinson
2005-01-01
Full Text Available The non-homogeneous model of nucleotide substitution proposed by Barry and Hartigan (Stat Sci, 2: 191-210 is the most general model of DNA evolution assuming an independent and identical process at each site. We present a computational solution for this model, and use it to analyse two data sets, each violating one or more of the assumptions of stationarity, homogeneity, and reversibility. The log likelihood values returned by programs based on the F84 model (J Mol Evol, 29: 170-179, the general time reversible model (J Mol Evol, 20: 86-93, and Barry and Hartigan’s model are compared to determine the validity of the assumptions made by the first two models. In addition, we present a method for assessing whether sequences have evolved under reversible conditions and discover that this is not so for the two data sets. Finally, we determine the most likely tree under the three models of DNA evolution and compare these with the one favoured by the tests for symmetry.
A Graphical User Interface to Generalized Linear Models in MATLAB
Directory of Open Access Journals (Sweden)
Peter Dunn
1999-07-01
Full Text Available Generalized linear models unite a wide variety of statistical models in a common theoretical framework. This paper discusses GLMLAB-software that enables such models to be fitted in the popular mathematical package MATLAB. It provides a graphical user interface to the powerful MATLAB computational engine to produce a program that is easy to use but with many features, including offsets, prior weights and user-defined distributions and link functions. MATLAB's graphical capacities are also utilized in providing a number of simple residual diagnostic plots.
A Generalized Preferential Attachment Model for Complex Systems
Yamasaki, K; Fu, D; Buldyrev, S V; Pammolli, F; Riccaboni, M; Stanley, H E; Yamasaki, Kazuko; Matia, Kaushik; Fu, Dongfeng; Buldyrev, Sergey V.; Pammolli, Fabio; Riccaboni, Massimo
2005-01-01
Complex systems can be characterized by classes of equivalency of their elements defined according to system specific rules. We propose a generalized preferential attachment model to describe the class size distribution. The model postulates preferential growth of the existing classes and the steady influx of new classes. We investigate how the distribution depends on the initial conditions and changes from a pure exponential form for zero influx of new classes to a power law with an exponential cutoff form when the influx of new classes is substantial. We apply the model to study the growth dynamics of pharmaceutical industry.
Concurrent approaches to Generalized Parton Distribution modeling: the pion's case
Chouika, N.; Mezrag, C.; Moutarde, H.; Rodríguez-Quintero, J.
2017-03-01
The concept of Generalized Parton Distributions promises an understanding of the generation of the charge, spin, and energy-momentum structure of hadrons by quarks and gluons. Forthcoming measurements with unprecedented accuracy at Jefferson Lab and at CERN will challenge our quantitative description of the three-dimensional structure of hadrons. To fully exploit these future measurements, new tools and models are currently being developed. We explain the difficulties of Generalized Parton Distribution modeling, and present some recent progresses. In particular we describe the symmetry-preserving Dyson-Schwinger and Bethe-Salpeter framework. We also discuss various equivalent parameterizations and sketch how to combine them to obtain models satisfying a priori all required theoretical constraints. At last we explain why these developments naturally fit in a versatile software framework, named PARTONS, dedicated to the theory and phenomenology of GPDs.
Holographic entanglement entropy in general holographic superconductor models
Peng, Yan
2014-01-01
We study the entanglement entropy of general holographic dual models both in AdS soliton and AdS black hole backgrounds with full backreaction. We find that the entanglement entropy is a good probe to explore the properties of the holographic superconductors and provides richer physics in the phase transition. We obtain the effects of the scalar mass, model parameter and backreaction on the entropy, and argue that the jump of the entanglement entropy may be a quite general feature for the first order phase transition. In strong contrast to the insulator/superconductor system, we note that the backreaction coupled with the scalar mass can not be used to trigger the first order phase transition if the model parameter is below its bottom bound in the metal/superconductor system.
THE ROC CURVE MODEL FROM GENERALIZED-EXPONENTIAL DISTRIBUTION
Directory of Open Access Journals (Sweden)
Ehtesham Hussain
2011-04-01
Full Text Available Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 In biomedical studies often yield continuously positively skewed (non- normal distributed data. In this regard Generalized-Exponential Distribution is suggested for analyzing such data. In this paper the parametric equation of the Receiving Operating Characteristic (ROC curve model is established under the assumptions of bi-distributional population based on pair of Generalized-Exponential Distributions. Also its maximum likelihood estimator MLE, sampling distribution , equivalence test statistic and exact confidence interval are derived.
Extended Generalized-K (EGK): A New Simple and General Model for Composite Fading Channels
Yilmaz, Ferkan
2010-01-01
In this paper, we introduce a generalized composite fading distribution (termed extended generalized-K (EGK)) to model the envelope and the power of the received signal in millimeter wave (60 GHz or above) and free-space optical channels. We obtain the first and the second-order statistics of the received signal envelope characterized by the EGK composite fading distribution. In particular, expressions for probability density function, cumulative distribution function, level crossing rate and average fade duration, and fractional moments are derived. In addition performance measures such as amount of fading, average bit error probability, outage probability, average capacity, and outage capacity are offered in closed-form. Selected numerical and computer simulation examples validate the accuracy of the presented mathematical analysis.
Klassen, Waldemar; Adams, Jean V.; Twohey, Michael B.
2004-01-01
The suppressive effects of trapping adult sea lampreys, Petromyzon marinus Linnaeus, and releasing sterile males (SMRT) or females (SFRT) into a closed system were expressed in deterministic models. Suppression was modeled as a function of the proportion of the population removed by trapping, the number of sterile animals released, the reproductive rate and sex ratio of the population, and (for the SFRT) the rate of polygyny. Releasing sterile males reduced populations more quickly than did the release of sterile females. For a population in which 30% are trapped, sterile animals are initially released at ratio of 10 sterile to 1 fertile animal, 5 adult progeny are produced per fertile mating, 60% are male, and males mate with an average of 1.65 females, the initial population is reduced 87% by SMRT and 68% by SFRT in one generation. The extent of suppression achieved is most sensitive to changes in the initial sterile release ratio. Given the current status of sea lamprey populations and trapping operations in the Great Lakes, the sterile-male-release technique has the best chance for success on a lake-wide basis if implemented in Lake Michigan. The effectiveness of the sterile-female-release technique should be investigated in a controlled study. Advancing trapping technology should be a high priority in the near term, and artificial rearing of sea lampreys to the adult stage should be a high priority in the long term. The diligent pursuit of sea lamprey suppression over a period of several decades can be expected to yield great benefits.
A generalized exponential time series regression model for electricity prices
DEFF Research Database (Denmark)
Haldrup, Niels; Knapik, Oskar; Proietti, Tomasso
We consider the issue of modeling and forecasting daily electricity spot prices on the Nord Pool Elspot power market. We propose a method that can handle seasonal and non-seasonal persistence by modelling the price series as a generalized exponential process. As the presence of spikes can distort...... the estimation of the dynamic structure of the series we consider an iterative estimation strategy which, conditional on a set of parameter estimates, clears the spikes using a data cleaning algorithm, and reestimates the parameters using the cleaned data so as to robustify the estimates. Conditional...... on the estimated model, the best linear predictor is constructed. Our modeling approach provides good fit within sample and outperforms competing benchmark predictors in terms of forecasting accuracy. We also find that building separate models for each hour of the day and averaging the forecasts is a better...
Hairy black holes in the general Skyrme model
Adam, C; Shnir, Ya; Wereszczynski, A
2016-01-01
We study the existence of hairy black holes in the generalized Einstein-Skyrme model. It is proven that in the BPS model limit there are no hairy black hole solutions, although the model admits gravitating (and flat space) solitons. Furthermore, we find strong evidence that a necessary condition for the existence of black holes with Skyrmionic hair is the inclusion of the Skyrme term $\\mathcal{L}_4$. As an example, we show that there are no hairy black holes in the $\\mathcal{L}_2+\\mathcal{L}_6+\\mathcal{L}_0$ model and present a new kind of black hole solutions with compact Skyrmion hair in the $\\mathcal{L}_4+\\mathcal{L}_6+\\mathcal{L}_0$ model.
A Generalized Gamma Mixture Model for Ultrasonic Tissue Characterization
Directory of Open Access Journals (Sweden)
Gonzalo Vegas-Sanchez-Ferrero
2012-01-01
Full Text Available Several statistical models have been proposed in the literature to describe the behavior of speckles. Among them, the Nakagami distribution has proven to very accurately characterize the speckle behavior in tissues. However, it fails when describing the heavier tails caused by the impulsive response of a speckle. The Generalized Gamma (GG distribution (which also generalizes the Nakagami distribution was proposed to overcome these limitations. Despite the advantages of the distribution in terms of goodness of fitting, its main drawback is the lack of a closed-form maximum likelihood (ML estimates. Thus, the calculation of its parameters becomes difficult and not attractive. In this work, we propose (1 a simple but robust methodology to estimate the ML parameters of GG distributions and (2 a Generalized Gama Mixture Model (GGMM. These mixture models are of great value in ultrasound imaging when the received signal is characterized by a different nature of tissues. We show that a better speckle characterization is achieved when using GG and GGMM rather than other state-of-the-art distributions and mixture models. Results showed the better performance of the GG distribution in characterizing the speckle of blood and myocardial tissue in ultrasonic images.
Local Signaling Environments and Human Male Infertility: What Can Be Learned from Mouse Models
2010-01-01
Infertility is one of the most prevalent public health problems facing young adult males in today’s society. A clear, treatable cause of infertility cannot be determined in a large number of these patients, and a growing body of evidence suggests that infertility in many of these men may be due to genetic causes. Studies utilizing animal models, and most importantly, mouse knockout technology, have been integral not only for the study of normal spermatogenesis but also for identifying protein...
Niaura, RS; Stroud, LR; Todaro, J; Ward, KD; Spiro, A; Aldwin, C; Landsberg, L; Weiss, ST
2003-01-01
We examined relationships between repression, general maladjustment, body mass index (BMI), and waist-to-hip ratio (WHR). The participants were 1,081 healthy older men from the Normative Aging Study. Repression and General Maladjustment Scales of the Minnesota Multiphasic Personality Inventory were
The Chaotic General Economic Equilibrium Model and Monopoly
Directory of Open Access Journals (Sweden)
Vesna D. Jablanovic
2012-09-01
Full Text Available The basic aim of this study is to construct a relatively simple chaotic general economic equilibrium growth model that is capable of generating stable equilibrium, cycles, or chaos. An important example of general economic equilibrium is provided by monopolies. A key hypothesis of this study is based on the idea that the coefficient π = b mRS/m (α-1 (1+1/e mRT plays a crucial role in explaining local stability of the general equilibrium output, where, b: The coefficient of the quadratic marginal-cost function, m: The coefficient of the inverse demand function, mRS: The marginal rate of substitution, mRT: Marginal rate of transformation, α: The coefficient of the monopoly price growth, e: The coefficient of the price elasticity of demand.
Pinning control of a generalized complex dynamical network model
Institute of Scientific and Technical Information of China (English)
Huizhong YANG; Li SHENG
2009-01-01
This paper investigates the local and global synchronization of a generalized complex dynamical network model with constant and delayed coupling.Without assuming symmetry of the couplings,we proved that a single controller can pin the generalized complex network to a homogenous solution.Some previous synchronization results are generalized.In this paper,we first discuss how to pin an array of delayed neural networks to the synchronous solution by adding only one controller.Next,by using the Lyapunov functional method,some sufficient conditions are derived for the local and global synchronization of the coupled systems.The obtained results are expressed in terms of LMIs,which can be efficiently checked by the Matlab LMI toolbox.Finally,an example is given to illustrate the theoretical results.
Invariants and flavour in the general Two Higgs Doublet Model
Energy Technology Data Exchange (ETDEWEB)
Botella, F.J., E-mail: fbotella@uv.es [Departament de Física Teòrica and IFIC, Universitat de València-CSIC, E-46100, Burjassot (Spain); Branco, G.C., E-mail: gustavo.branco@cern.ch [Departamento de Física and Centro de Física Teórica de Partículas (CFTP), Instituto Superior Técnico, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal); Rebelo, M.N., E-mail: margarida.rebelo@cern.ch [Universidade Técnica de Lisboa, Centro de Física Teórica de Partículas (CFTP), Instituto Superior Técnico, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal)
2013-05-13
The flavour structure of the general Two Higgs Doublet Model (2HDM) is analysed and a detailed study of the parameter space is presented, showing that flavour mixing in the 2HDM can be parametrized by various unitary matrices which arise from the misalignment in flavour space between pairs of various Hermitian flavour matrices which can be constructed within the model. This is entirely analogous to the generation of the CKM matrix in the Standard Model (SM). We construct weak basis invariants which can give insight into the physical implications of any flavour model, written in an arbitrary weak basis (WB) in the context of 2HDM. We apply this technique to two special cases, models with MFV and models with NNI structures. In both cases non-trivial CP-odd WB invariants arise in a mass power order much smaller than what one encounters in the SM, which can have important implications for baryogenesis in the framework of the general 2HDM.
Attractive Hubbard model with disorder and the generalized Anderson theorem
Energy Technology Data Exchange (ETDEWEB)
Kuchinskii, E. Z., E-mail: kuchinsk@iep.uran.ru; Kuleeva, N. A., E-mail: strigina@iep.uran.ru; Sadovskii, M. V., E-mail: sadovski@iep.uran.ru [Russian Academy of Sciences, Institute for Electrophysics, Ural Branch (Russian Federation)
2015-06-15
Using the generalized DMFT+Σ approach, we study the influence of disorder on single-particle properties of the normal phase and the superconducting transition temperature in the attractive Hubbard model. A wide range of attractive potentials U is studied, from the weak coupling region, where both the instability of the normal phase and superconductivity are well described by the BCS model, to the strong-coupling region, where the superconducting transition is due to Bose-Einstein condensation (BEC) of compact Cooper pairs, formed at temperatures much higher than the superconducting transition temperature. We study two typical models of the conduction band with semi-elliptic and flat densities of states, respectively appropriate for three-dimensional and two-dimensional systems. For the semi-elliptic density of states, the disorder influence on all single-particle properties (e.g., density of states) is universal for an arbitrary strength of electronic correlations and disorder and is due to only the general disorder widening of the conduction band. In the case of a flat density of states, universality is absent in the general case, but still the disorder influence is mainly due to band widening, and the universal behavior is restored for large enough disorder. Using the combination of DMFT+Σ and Nozieres-Schmitt-Rink approximations, we study the disorder influence on the superconducting transition temperature T{sub c} for a range of characteristic values of U and disorder, including the BCS-BEC crossover region and the limit of strong-coupling. Disorder can either suppress T{sub c} (in the weak-coupling region) or significantly increase T{sub c} (in the strong-coupling region). However, in all cases, the generalized Anderson theorem is valid and all changes of the superconducting critical temperature are essentially due to only the general disorder widening of the conduction band.
Optimal reinsurance/investment problems for general insurance models
Liu, Yuping; 10.1214/08-AAP582
2009-01-01
In this paper the utility optimization problem for a general insurance model is studied. The reserve process of the insurance company is described by a stochastic differential equation driven by a Brownian motion and a Poisson random measure, representing the randomness from the financial market and the insurance claims, respectively. The random safety loading and stochastic interest rates are allowed in the model so that the reserve process is non-Markovian in general. The insurance company can manage the reserves through both portfolios of the investment and a reinsurance policy to optimize a certain utility function, defined in a generic way. The main feature of the problem lies in the intrinsic constraint on the part of reinsurance policy, which is only proportional to the claim-size instead of the current level of reserve, and hence it is quite different from the optimal investment/consumption problem with constraints in finance. Necessary and sufficient conditions for both well posedness and solvability...
A Non-Gaussian Spatial Generalized Linear Latent Variable Model
Irincheeva, Irina
2012-08-03
We consider a spatial generalized linear latent variable model with and without normality distributional assumption on the latent variables. When the latent variables are assumed to be multivariate normal, we apply a Laplace approximation. To relax the assumption of marginal normality in favor of a mixture of normals, we construct a multivariate density with Gaussian spatial dependence and given multivariate margins. We use the pairwise likelihood to estimate the corresponding spatial generalized linear latent variable model. The properties of the resulting estimators are explored by simulations. In the analysis of an air pollution data set the proposed methodology uncovers weather conditions to be a more important source of variability than air pollution in explaining all the causes of non-accidental mortality excluding accidents. © 2012 International Biometric Society.
On virtual states and generalized completeness relation in Friedrichs Model
Xiao, Zhiguang
2016-01-01
We study the well-known Friedrichs model, in which a discrete state is coupled to a continuum state. By examining the pole behaviors of the Friedrichs model in a specific form factor thoroughly, we find that, in general, when the bare discrete state is below the threshold of the continuum state, there should also be a virtual-state pole accompanying the bound-state pole originating from the bare discrete state as the coupling is turned on. There are also other second-sheet poles originating from the singularities of the form factor. We give a general argument for the existence of these two kinds of states. As the coupling is increased to a certain value, the second-sheet poles may merge and become higher-order poles. We then discuss the completeness relations incorporating bound states, virtual states, and resonant states corresponding to higher-order poles.
Aeolian Sediment Transport Integration in General Stratigraphic Forward Modeling
Directory of Open Access Journals (Sweden)
T. Salles
2011-01-01
Full Text Available A large number of numerical models have been developed to simulate the physical processes involved in saltation, and, recently to investigate the interaction between soil vegetation cover and aeolian transport. These models are generally constrained to saltation of monodisperse particles while natural saltation occurs over mixed soils. We present a three-dimensional numerical model of steady-state saltation that can simulate aeolian erosion, transport and deposition for unvegetated mixed soils. Our model simulates the motion of saltating particles using a cellular automata algorithm. A simple set of rules is used and takes into account an erosion formula, a transport model, a wind exposition function, and an avalanching process. The model is coupled to the stratigraphic forward model Sedsim that accounts for a larger number of geological processes. The numerical model predicts a wide range of typical dune shapes, which have qualitative correspondence to real systems. The model reproduces the internal structure and composition of the resulting aeolian deposits. It shows the complex formation of dune systems with cross-bedding strata development, bounding surfaces overlaid by fine sediment and inverse grading deposits. We aim to use it to simulate the complex interactions between different sediment transport processes and their resulting geological morphologies.
Treatment of cloud radiative effects in general circulation models
Energy Technology Data Exchange (ETDEWEB)
Wang, W.C.; Dudek, M.P.; Liang, X.Z.; Ding, M. [State Univ. of New York, Albany, NY (United States)] [and others
1996-04-01
We participate in the Atmospheric Radiation Measurement (ARM) program with two objectives: (1) to improve the general circulation model (GCM) cloud/radiation treatment with a focus on cloud verticle overlapping and layer cloud optical properties, and (2) to study the effects of cloud/radiation-climate interaction on GCM climate simulations. This report summarizes the project progress since the Fourth ARM Science Team meeting February 28-March 4, 1994, in Charleston, South Carolina.
Unitary transformation method for solving generalized Jaynes-Cummings models
Indian Academy of Sciences (India)
Sudha Singh
2006-03-01
Two fully quantized generalized Jaynes-Cummings models for the interaction of a two-level atom with radiation field are treated, one involving intensity dependent coupling and the other involving multiphoton interaction between the field and the atom. The unitary transformation method presented here not only solves the time dependent problem but also allows a determination of the eigensolutions of the interacting Hamiltonian at the same time.
Conditional likelihood inference in generalized linear mixed models.
Sartori, Nicola; Severini , T.A
2002-01-01
Consider a generalized linear model with a canonical link function, containing both fixed and random effects. In this paper, we consider inference about the fixed effects based on a conditional likelihood function. It is shown that this conditional likelihood function is valid for any distribution of the random effects and, hence, the resulting inferences about the fixed effects are insensitive to misspecification of the random effects distribution. Inferences based on the conditional likelih...
Credibility analysis of risk classes by generalized linear model
Erdemir, Ovgucan Karadag; Sucu, Meral
2016-06-01
In this paper generalized linear model (GLM) and credibility theory which are frequently used in nonlife insurance pricing are combined for reliability analysis. Using full credibility standard, GLM is associated with limited fluctuation credibility approach. Comparison criteria such as asymptotic variance and credibility probability are used to analyze the credibility of risk classes. An application is performed by using one-year claim frequency data of a Turkish insurance company and results of credible risk classes are interpreted.
Generalized Bogoliubov Polariton Model: An Application to Stock Exchange Market
Thuy Anh, Chu; Anh, Truong Thi Ngoc; Lan, Nguyen Tri; Viet, Nguyen Ai
2016-06-01
A generalized Bogoliubov method for investigation non-simple and complex systems was developed. We take two branch polariton Hamiltonian model in second quantization representation and replace the energies of quasi-particles by two distribution functions of research objects. Application to stock exchange market was taken as an example, where the changing the form of return distribution functions from Boltzmann-like to Gaussian-like was studied.
Scalar products in generalized models with SU(3)-symmetry
Wheeler, M.
2012-01-01
We consider a generalized model with SU(3)-invariant R-matrix, and review the nested Bethe Ansatz for constructing eigenvectors of the transfer matrix. A sum formula for the scalar product between generic Bethe vectors, originally obtained by Reshetikhin [11], is discussed. This formula depends on a certain partition function Z(\\{\\lambda\\},\\{\\mu\\}|\\{w\\},\\{v\\}), which we evaluate explicitly. In the limit when the variables \\{\\mu\\} or \\{v\\} approach infinity, this object reduces to the domain w...
A General Theoretical Model of Enthalpy-EntropyCompensation
Institute of Scientific and Technical Information of China (English)
LIU，Lei; GUO, Qing-Xiang
2001-01-01
Enthalpy-entropy compensation remains a mystery in chemistry and biophysics.recent study suggested that the solventreorganization might constitute the physical orihin of the compensation, which was unforumstely not wisely applicable because compensation was also observeserved in solid phade reactions.In this study,a general theoretical model based upon strictmathematical deduction was presented,which indicated thatthe redistribution of the distinguishable subspecies might bethe physical origin of the enthalpy-intropy compensations in solvation and surface adsorption weue discussed.
Electromagnetic axial anomaly in a generalized linear sigma model
Fariborz, Amir H.; Jora, Renata
2017-06-01
We construct the electromagnetic anomaly effective term for a generalized linear sigma model with two chiral nonets, one with a quark-antiquark structure, the other one with a four-quark content. We compute in the leading order of this framework the decays into two photons of six pseudoscalars: π0(137 ), π0(1300 ), η (547 ), η (958 ), η (1295 ) and η (1760 ). Our results agree well with the available experimental data.
Schwartz, Doron; Moreno, Daniel P; Stitzel, Joel D; Gayzik, F Scott
2014-01-01
A simplified lower extremity model was developed using the geometry from the Global Human Body Models Consortium (GHBMC) 50th percentile male occupant model v4.1.1 (M50) as a base. This simplified model contains 31.4x103 elements and has structures that represent bone (assumed rigid) and soft tissue. This element total is substantially reduced compared to 117.7x103 elements in the original M50 lower extremity. The purpose of this simplified computational model is to output rapid kinematic and kinetic data when detailed structural response or injury prediction data is not required. The development process included evaluating the effects of element size, material properties, and contact definitions on total run time and response. Two simulations were performed to analyze this model; a 4.9 m/s knee bolster impact and a 6.9 m/s lateral knee impact using LS-DYNA R6.1.1. The 40 ms knee bolster impact and lateral knee impact tests required 5 and 7 minutes to run, respectively on 4 cores. The original detailed M50 lower extremity model required 94 and 112 minutes to run the same boundary conditions, on the same hardware, representing a reduction in run time of on average 94%. A quantitative comparison was made by comparing the peak force of the impacts between the two models. This simplified leg model will become a component in a simplified full body model of the seated, 50th percentile male occupant. The significantly reduced run time will be valuable for parametric studies with a full body finite element model.
Structural dynamic analysis with generalized damping models analysis
Adhikari , Sondipon
2013-01-01
Since Lord Rayleigh introduced the idea of viscous damping in his classic work ""The Theory of Sound"" in 1877, it has become standard practice to use this approach in dynamics, covering a wide range of applications from aerospace to civil engineering. However, in the majority of practical cases this approach is adopted more for mathematical convenience than for modeling the physics of vibration damping. Over the past decade, extensive research has been undertaken on more general ""non-viscous"" damping models and vibration of non-viscously damped systems. This book, along with a related book
Generalized model for Memristor-based Wien family oscillators
Talukdar, Abdul Hafiz Ibne
2012-07-23
In this paper, we report the unconventional characteristics of Memristor in Wien oscillators. Generalized mathematical models are developed to analyze four members of the Wien family using Memristors. Sustained oscillation is reported for all types though oscillating resistance and time dependent poles are present. We have also proposed an analytical model to estimate the desired amplitude of oscillation before the oscillation starts. These Memristor-based oscillation results, presented for the first time, are in good agreement with simulation results. © 2011 Elsevier Ltd.
Regularization Paths for Generalized Linear Models via Coordinate Descent
Directory of Open Access Journals (Sweden)
Jerome Friedman
2010-02-01
Full Text Available We develop fast algorithms for estimation of generalized linear models with convex penalties. The models include linear regression, two-class logistic regression, and multi- nomial regression problems while the penalties include ℓ1 (the lasso, ℓ2 (ridge regression and mixtures of the two (the elastic net. The algorithms use cyclical coordinate descent, computed along a regularization path. The methods can handle large problems and can also deal efficiently with sparse features. In comparative timings we find that the new algorithms are considerably faster than competing methods.
Principle Generalized Net Model of a Human Stress Reaction
Directory of Open Access Journals (Sweden)
Anthony Shannon
2008-04-01
Full Text Available The present study was aimed at investigating the mechanism of a human stress reaction by means of Generalized Nets (GNs. A principle GN-model of the main structures, organs and systems of the human body taking part in the acute and chronic reaction of the organism to a stress stimulus is generated. A possible application of the GN-model of the human stress reaction for testing the effect of known or newly synthesized pharmacological products as well as of food supplements is discussed.
Automorphisms and Generalized Involution Models of Finite Complex Reflection Groups
Marberg, Eric
2010-01-01
We prove that a finite complex reflection group has a generalized involution model, as defined by Bump and Ginzburg, if and only if each of its irreducible factors is either $G(r,p,n)$ with $\\gcd(p,n)=1$; $G(r,p,2)$ with $r/p$ odd; or $G_{23}$, the Coxeter group of type $H_3$. We additionally provide explicit formulas for all automorphisms of $G(r,p,n)$, and construct new Gelfand models for the groups $G(r,p,n)$ with $\\gcd(p,n)=1$.
Tropical disturbances in relation to general circulation modeling
Estoque, M. A.
1982-01-01
The initial results of an evaluation of the performance of the Goddard Laboratory of Atmospheric Simulation general circulation model depicting the tropical atmosphere during the summer are presented. Because the results show the existence of tropical wave disturbances throughout the tropics, the characteristics of synoptic disturbances over Africa were studied and a synoptic case study of a selected disturbance in this area was conducted. It is shown that the model is able to reproduce wave type synoptic disturbances in the tropics. The findings show that, in one of the summers simulated, the disturbances are predominantly closed vortices; in another summer, the predominant disturbances are open waves.
Anisotropic Mesoscale Eddy Transport in Ocean General Circulation Models
Reckinger, S. J.; Fox-Kemper, B.; Bachman, S.; Bryan, F.; Dennis, J.; Danabasoglu, G.
2014-12-01
Modern climate models are limited to coarse-resolution representations of large-scale ocean circulation that rely on parameterizations for mesoscale eddies. The effects of eddies are typically introduced by relating subgrid eddy fluxes to the resolved gradients of buoyancy or other tracers, where the proportionality is, in general, governed by an eddy transport tensor. The symmetric part of the tensor, which represents the diffusive effects of mesoscale eddies, is universally treated isotropically in general circulation models. Thus, only a single parameter, namely the eddy diffusivity, is used at each spatial and temporal location to impart the influence of mesoscale eddies on the resolved flow. However, the diffusive processes that the parameterization approximates, such as shear dispersion, potential vorticity barriers, oceanic turbulence, and instabilities, typically have strongly anisotropic characteristics. Generalizing the eddy diffusivity tensor for anisotropy extends the number of parameters to three: a major diffusivity, a minor diffusivity, and the principal axis of alignment. The Community Earth System Model (CESM) with the anisotropic eddy parameterization is used to test various choices for the newly introduced parameters, which are motivated by observations and the eddy transport tensor diagnosed from high resolution simulations. Simply setting the ratio of major to minor diffusivities to a value of five globally, while aligning the major axis along the flow direction, improves biogeochemical tracer ventilation and reduces global temperature and salinity biases. These effects can be improved even further by parameterizing the anisotropic transport mechanisms in the ocean.
Border Collision Bifurcations in a Generalized Model of Population Dynamics
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Lilia M. Ladino
2016-01-01
Full Text Available We analyze the dynamics of a generalized discrete time population model of a two-stage species with recruitment and capture. This generalization, which is inspired by other approaches and real data that one can find in literature, consists in considering no restriction for the value of the two key parameters appearing in the model, that is, the natural death rate and the mortality rate due to fishing activity. In the more general case the feasibility of the system has been preserved by posing opportune formulas for the piecewise map defining the model. The resulting two-dimensional nonlinear map is not smooth, though continuous, as its definition changes as any border is crossed in the phase plane. Hence, techniques from the mathematical theory of piecewise smooth dynamical systems must be applied to show that, due to the existence of borders, abrupt changes in the dynamic behavior of population sizes and multistability emerge. The main novelty of the present contribution with respect to the previous ones is that, while using real data, richer dynamics are produced, such as fluctuations and multistability. Such new evidences are of great interest in biology since new strategies to preserve the survival of the species can be suggested.
Generalized linear models with coarsened covariates: a practical Bayesian approach.
Johnson, Timothy R; Wiest, Michelle M
2014-06-01
Coarsened covariates are a common and sometimes unavoidable phenomenon encountered in statistical modeling. Covariates are coarsened when their values or categories have been grouped. This may be done to protect privacy or to simplify data collection or analysis when researchers are not aware of their drawbacks. Analyses with coarsened covariates based on ad hoc methods can compromise the validity of inferences. One valid method for accounting for a coarsened covariate is to use a marginal likelihood derived by summing or integrating over the unknown realizations of the covariate. However, algorithms for estimation based on this approach can be tedious to program and can be computationally expensive. These are significant obstacles to their use in practice. To overcome these limitations, we show that when expressed as a Bayesian probability model, a generalized linear model with a coarsened covariate can be posed as a tractable missing data problem where the missing data are due to censoring. We also show that this model is amenable to widely available general-purpose software for simulation-based inference for Bayesian probability models, providing researchers a very practical approach for dealing with coarsened covariates.
Item Response Theory Using Hierarchical Generalized Linear Models
Directory of Open Access Journals (Sweden)
Hamdollah Ravand
2015-03-01
Full Text Available Multilevel models (MLMs are flexible in that they can be employed to obtain item and person parameters, test for differential item functioning (DIF and capture both local item and person dependence. Papers on the MLM analysis of item response data have focused mostly on theoretical issues where applications have been add-ons to simulation studies with a methodological focus. Although the methodological direction was necessary as a first step to show how MLMs can be utilized and extended to model item response data, the emphasis needs to be shifted towards providing evidence on how applications of MLMs in educational testing can provide the benefits that have been promised. The present study uses foreign language reading comprehension data to illustrate application of hierarchical generalized models to estimate person and item parameters, differential item functioning (DIF, and local person dependence in a three-level model.
The linear model and hypothesis a general unifying theory
Seber, George
2015-01-01
This book provides a concise and integrated overview of hypothesis testing in four important subject areas, namely linear and nonlinear models, multivariate analysis, and large sample theory. The approach used is a geometrical one based on the concept of projections and their associated idempotent matrices, thus largely avoiding the need to involve matrix ranks. It is shown that all the hypotheses encountered are either linear or asymptotically linear, and that all the underlying models used are either exactly or asymptotically linear normal models. This equivalence can be used, for example, to extend the concept of orthogonality in the analysis of variance to other models, and to show that the asymptotic equivalence of the likelihood ratio, Wald, and Score (Lagrange Multiplier) hypothesis tests generally applies.
Modelling Socio-Economic Differences in the Mortality of Danish Males Using a New Affluence Index
DEFF Research Database (Denmark)
Cairns, Andrew J.G.; Kallestrup-Lamb, Malene; Rosenskjold, Carsten Paysen T.
We investigate and model how the mortality of Danish males aged 55-94 has changed over the period 1985-2012. We divide the population into ten socio-economic subgroups using a new measure of affluence that combines wealth and income reported on the Statistics Denmark national register database...... possible without losing the essential character of the raw data. The model produces bio-demographically reasonable forecasts of mortality rates that preserve the sub-group rankings at all ages. It also satisfies reasonableness criteria related to the term structure of correlations across ages and over time...
Predicting the Probability of Lightning Occurrence with Generalized Additive Models
Fabsic, Peter; Mayr, Georg; Simon, Thorsten; Zeileis, Achim
2017-04-01
This study investigates the predictability of lightning in complex terrain. The main objective is to estimate the probability of lightning occurrence in the Alpine region during summertime afternoons (12-18 UTC) at a spatial resolution of 64 × 64 km2. Lightning observations are obtained from the ALDIS lightning detection network. The probability of lightning occurrence is estimated using generalized additive models (GAM). GAMs provide a flexible modelling framework to estimate the relationship between covariates and the observations. The covariates, besides spatial and temporal effects, include numerous meteorological fields from the ECMWF ensemble system. The optimal model is chosen based on a forward selection procedure with out-of-sample mean squared error as a performance criterion. Our investigation shows that convective precipitation and mid-layer stability are the most influential meteorological predictors. Both exhibit intuitive, non-linear trends: higher values of convective precipitation indicate higher probability of lightning, and large values of the mid-layer stability measure imply low lightning potential. The performance of the model was evaluated against a climatology model containing both spatial and temporal effects. Taking the climatology model as a reference forecast, our model attains a Brier Skill Score of approximately 46%. The model's performance can be further enhanced by incorporating the information about lightning activity from the previous time step, which yields a Brier Skill Score of 48%. These scores show that the method is able to extract valuable information from the ensemble to produce reliable spatial forecasts of the lightning potential in the Alps.
A general mixture model for sediment laden flows
Liang, Lixin; Yu, Xiping; Bombardelli, Fabián
2017-09-01
A mixture model for general description of sediment-laden flows is developed based on an Eulerian-Eulerian two-phase flow theory, with the aim at gaining computational speed in the prediction, but preserving the accuracy of the complete two-fluid model. The basic equations of the model include the mass and momentum conservation equations for the sediment-water mixture, and the mass conservation equation for sediment. However, a newly-obtained expression for the slip velocity between phases allows for the computation of the sediment motion, without the need of solving the momentum equation for sediment. The turbulent motion is represented for both the fluid and the particulate phases. A modified k-ε model is used to describe the fluid turbulence while an algebraic model is adopted for turbulent motion of particles. A two-dimensional finite difference method based on the SMAC scheme was used to numerically solve the mathematical model. The model is validated through simulations of fluid and suspended sediment motion in steady open-channel flows, both in equilibrium and non-equilibrium states, as well as in oscillatory flows. The computed sediment concentrations, horizontal velocity and turbulent kinetic energy of the mixture are all shown to be in good agreement with available experimental data, and importantly, this is done at a fraction of the computational efforts required by the complete two-fluid model.
Directory of Open Access Journals (Sweden)
Norshalizah Mamikutty
2014-01-01
Full Text Available Background. Metabolic syndrome can be caused by modification of diet by means of consumption of high carbohydrate and high fat diet such as fructose. Aims. To develop a metabolic syndrome rat model by induction of fructose drinking water (FDW in male Wistar rats. Methods. Eighteen male Wistar rats were fed with FDW 20% and FDW 25% for a duration of eight weeks. The physiological changes with regard to food and fluid intake, as well as calorie intake, were measured. The metabolic changes such as obesity, dyslipidaemia, hypertension, and hyperglycaemia were determined. Data was presented in mean ± SEM subjected to one-way ANOVA. Results. Male Wistar rats fed with FDW 20% for eight weeks developed significant higher obesity parameters compared to those fed with FDW 25%. There was hypertrophy of adipocytes in F20 and F25. There were also systolic hypertension, hypertriglyceridemia, and hyperglycemia in both groups. Conclusion. We conclude that the metabolic syndrome rat model is best established with the induction of FDW 20% for eight weeks. This was evident in the form of higher obesity parameter which caused the development of the metabolic syndrome.
Generalized effective medium resistivity model for low resistivity reservoir
Institute of Scientific and Technical Information of China (English)
2008-01-01
With the advancement in oil exploration,producible oil and gas are being found in low resistivity reservoirs,which may otherwise be erroneously thought as water zones from their resistivity.However,the evaluation of low resistivity reservoirs remains difficult from log interpretation.Since low resistivity in hydrocarbon bearing sands can be caused by dispersed clay,laminated shale,conductive matrix grains,microscopic capillary pores and high saline water,a new resistivity model is required for more accurate hydrocarbon saturation prediction for low resistivity formations.Herein,a generalized effective medium resistivity model has been proposed for low resistivity reservoirs,based on experimental measurements on artificial low resistivity shaly sand samples,symmetrical anisotropic effective medium theory for resistivity interpretations,and geneses and conductance mechanisms of low resistivity reservoirs.By analyzing effects of some factors on the proposed model,we show theoretically the model can describe conductance mechanisms of low resistivity reservoirs with five geneses.Also,shale distribution largely affects water saturation predicted by the model.Resistivity index decreases as fraction and conductivity of laminated shale,or fraction of dispersed clay,or conductivity of rock matrix grains increases.Resistivity index decreases as matrix percolation exponent,or percolation rate of capillary bound water increases,and as percolation exponent of capillary bound water,or matrix percolation rate,or free water percolation rate decreases.Rock sample data from low resistivity reservoirs with different geneses and interpretation results for log data show that the proposed model can be applied in low resistivity reservoirs containing high salinity water,dispersed clay,microscopic capillary pores,laminated shale and conductive matrix grains,and thus is considered as a generalized resistivity model for low resistivity reservoir evaluation.
Generalized effective medium resistivity model for low resistivity reservoir
Institute of Scientific and Technical Information of China (English)
SONG YanJie; TANG XiaoMin
2008-01-01
With the advancement in oil exploration, producible oil and gas are being found in low resistivity reservoirs, which may otherwise be erroneously thought as water zones from their resistivity. However,the evaluation of low resistivity reservoirs remains difficult from log interpretation. Since low resistivity in hydrocarbon bearing sands can be caused by dispersed clay, laminated shale, conductive matrix grains, microscopic capillary pores and high saline water, a new resistivity model is required for more accurate hydrocarbon saturation prediction for low resistivity formations. Herein, a generalized effective medium resistivity model has been proposed for low resistivity reservoirs, based on experimental measurements on artificial low resistivity shaly sand samples, symmetrical anisotropic effective medium theory for resistivity interpretations, and geneses and conductance mechanisms of low resistivity reservoirs. By analyzing effects of some factors on the proposed model, we show theoretically the model can describe conductance mechanisms of low resistivity reservoirs with five geneses. Also,shale distribution largely affects water saturation predicted by the model. Resistivity index decreases as fraction and conductivity of laminated shale, or fraction of dispersed clay, or conductivity of rock matrix grains increases. Resistivity index decreases as matrix percolation exponent, or percolation rate of capillary bound water increases, and as percolation exponent of capillary bound water, or matrix percolation rate, or free water percolation rate decreases. Rock sample data from low resistivity reservoirs with different geneses and interpretation results for log data show that the proposed model can be applied in low resistivity reservoirs containing high salinity water, dispersed clay, microscopic capillary pores, laminated shale and conductive matrix grains, and thus is considered as a generalized resistivity model for low resistivity reservoir evaluation.
Bayesian generalized linear mixed modeling of Tuberculosis using informative priors.
Ojo, Oluwatobi Blessing; Lougue, Siaka; Woldegerima, Woldegebriel Assefa
2017-01-01
TB is rated as one of the world's deadliest diseases and South Africa ranks 9th out of the 22 countries with hardest hit of TB. Although many pieces of research have been carried out on this subject, this paper steps further by inculcating past knowledge into the model, using Bayesian approach with informative prior. Bayesian statistics approach is getting popular in data analyses. But, most applications of Bayesian inference technique are limited to situations of non-informative prior, where there is no solid external information about the distribution of the parameter of interest. The main aim of this study is to profile people living with TB in South Africa. In this paper, identical regression models are fitted for classical and Bayesian approach both with non-informative and informative prior, using South Africa General Household Survey (GHS) data for the year 2014. For the Bayesian model with informative prior, South Africa General Household Survey dataset for the year 2011 to 2013 are used to set up priors for the model 2014.
Fermion Masses and Mixing in General Warped Extra Dimensional Models
Frank, Mariana; Pourtolami, Nima; Toharia, Manuel
2015-01-01
We analyze fermion masses and mixing in a general warped extra dimensional model, where all the Standard Model (SM) fields, including the Higgs, are allowed to propagate in the bulk. In this context, a slightly broken flavor symmetry imposed universally on all fermion fields, without distinction, can generate the full flavor structure of the SM, including quarks, charged leptons and neutrinos. For quarks and charged leptons, the exponential sensitivity of their wave-functions to small flavor breaking effects yield naturally hierarchical masses and mixing as it is usual in warped models with fermions in the bulk. In the neutrino sector, the exponential wave-function factors can be flavor-blind and thus insensitive to the small flavor symmetry breaking effects, directly linking their masses and mixing angles to the flavor symmetric structure of the 5D neutrino Yukawa couplings. The Higgs must be localized in the bulk and the model is naturally more successful in generalized warped scenarios where the metric bac...
Fermion masses and mixing in general warped extra dimensional models
Frank, Mariana; Hamzaoui, Cherif; Pourtolami, Nima; Toharia, Manuel
2015-06-01
We analyze fermion masses and mixing in a general warped extra dimensional model, where all the Standard Model (SM) fields, including the Higgs, are allowed to propagate in the bulk. In this context, a slightly broken flavor symmetry imposed universally on all fermion fields, without distinction, can generate the full flavor structure of the SM, including quarks, charged leptons and neutrinos. For quarks and charged leptons, the exponential sensitivity of their wave functions to small flavor breaking effects yield hierarchical masses and mixing as it is usual in warped models with fermions in the bulk. In the neutrino sector, the exponential wave-function factors can be flavor blind and thus insensitive to the small flavor symmetry breaking effects, directly linking their masses and mixing angles to the flavor symmetric structure of the five-dimensional neutrino Yukawa couplings. The Higgs must be localized in the bulk and the model is more successful in generalized warped scenarios where the metric background solution is different than five-dimensional anti-de Sitter (AdS5 ). We study these features in two simple frameworks, flavor complimentarity and flavor democracy, which provide specific predictions and correlations between quarks and leptons, testable as more precise data in the neutrino sector becomes available.
Generalized Manning Condensation Model Captures the RNA Ion Atmosphere
Hayes, Ryan L.; Noel, Jeffrey K.; Mandic, Ana; Whitford, Paul C.; Sanbonmatsu, Karissa Y.; Mohanty, Udayan; Onuchic, José N.
2016-01-01
RNA is highly sensitive to the ionic environment, and typically requires Mg2+ to form compact structures. There is a need for models capable of describing the ion atmosphere surrounding RNA with quantitative accuracy. We present a model of RNA electrostatics and apply it within coarse-grained molecular dynamics simulation. The model treats Mg2+ ions explicitly to account for ion-ion correlations neglected by mean field theories. Since mean-field theories capture KCl well, it is treated implicitly by a generalized Manning counterion condensation model. The model extends Manning condensation to deal with arbitrary RNA conformations, non-limiting KCl concentrations, and the ion inaccessible volume of RNA. The model is tested against experimental measurements of the excess Mg2+ associated with the RNA, Γ2+, because Γ2+ is directly related to the Mg2+-RNA interaction free energy. The excellent agreement with experiment demonstrates the model captures the ionic dependence of the RNA free energy landscape. PMID:26197147
Generalized Semi-Analytical Models of Supernova Light Curves
Chatzopoulos, Emmanouil; Vinko, Jozsef
2011-01-01
We present generalized supernova (SN) light curve (LC) models for a variety of power inputs. We provide an expression for the power input that is produced by self-similar forward and reverse shocks in SN ejecta - circumstellar matter (CSM) interaction. We find that this ejecta-CSM interaction luminosity is in agreement with results from multi-dimensional radiation hydrodynamics simulations in the optically-thin case. We develop a model for the case of an optically-thick CSM by invoking an approximation for the effects of radiative diffusion. In the context of this model, we provide predictions for the time of forward shock break-out from the optically-thick part of the CSM envelope. We also introduce a hybrid LC model that incorporates ejecta-CSM interaction plus Ni-56 and Co-56 radioactive decay input. We fit this hybrid model to the LC of the Super-Luminous Supernova (SLSN) 2006gy. We find that this model provides a better fit to the LC of this event than previously presented models. We also address the rel...
A new approach for modeling generalization gradients: A case for Hierarchical Models
Directory of Open Access Journals (Sweden)
Koen eVanbrabant
2015-05-01
Full Text Available A case is made for the use of hierarchical models in the analysis of generalization gradients. Hierarchical models overcome several restrictions that are imposed by repeated measures analysis-of-variance (rANOVA, the default statistical method in current generalization research. More specifically, hierarchical models allow to include continuous independent variables and overcomes problematic assumptions such as sphericity. We focus on how generalization research can benefit from this added flexibility. In a simulation study we demonstrate the dominance of hierarchical models over rANOVA. In addition, we show the lack of efficiency of the Mauchly's sphericity test in sample sizes typical for generalization research, and confirm how violations of sphericity increase the probability of type I errors. A worked example of a hierarchical model is provided, with a specific emphasis on the interpretation of parameters relevant for generalization research.
A new approach for modeling generalization gradients: a case for hierarchical models.
Vanbrabant, Koen; Boddez, Yannick; Verduyn, Philippe; Mestdagh, Merijn; Hermans, Dirk; Raes, Filip
2015-01-01
A case is made for the use of hierarchical models in the analysis of generalization gradients. Hierarchical models overcome several restrictions that are imposed by repeated measures analysis-of-variance (rANOVA), the default statistical method in current generalization research. More specifically, hierarchical models allow to include continuous independent variables and overcomes problematic assumptions such as sphericity. We focus on how generalization research can benefit from this added flexibility. In a simulation study we demonstrate the dominance of hierarchical models over rANOVA. In addition, we show the lack of efficiency of the Mauchly's sphericity test in sample sizes typical for generalization research, and confirm how violations of sphericity increase the probability of type I errors. A worked example of a hierarchical model is provided, with a specific emphasis on the interpretation of parameters relevant for generalization research.
Construction of an extended library of adult male 3D models: rationale and results
Broggio, D.; Beurrier, J.; Bremaud, M.; Desbrée, A.; Farah, J.; Huet, C.; Franck, D.
2011-12-01
In order to best cover the possible extent of heights and weights of male adults the construction of 25 whole body 3D models has been undertaken. Such a library is thought to be useful to specify the uncertainties and relevance of dosimetry calculations carried out with models representing individuals of average body heights and weights. Representative 3D models of Caucasian body types are selected in a commercial database according to their height and weight, and 3D models of the skeleton and internal organs are designed using another commercial dataset. A review of the literature enabled one to fix volume or mass target values for the skeleton, soft organs, skin and fat content of the selected individuals. The composition of the remainder tissue is fixed so that the weight of the voxel models equals the weight of the selected individuals. After mesh and NURBS modelling, volume adjustment of the selected body shapes and additional voxel-based work, 25 voxel models with 109 identified organs or tissue are obtained. Radiation transport calculations are carried out with some of the developed models to illustrate potential uses. The following points are discussed throughout this paper: justification of the fixed or obtained models' features regarding available and relevant literature data; workflow and strategy for major modelling steps; advantages and drawbacks of the obtained library as compared with other works. The construction hypotheses are explained and justified in detail since future calculation results obtained with this library will depend on them.
Toward a general evaluation model for soil respiration (GEMSR)
Institute of Scientific and Technical Information of China (English)
2008-01-01
Soil respiration is an important component of terrestrial carbon budget. Its accurate evaluation is es- sential to the study of terrestrial carbon source/sink. Studies on soil respiration at present mostly focus on the temporal variations and the controlling factors of soil respiration, but its spatial variations and controlling factors draw less attention. Moreover, the evaluation models for soil respiration at present include only the effects of water and heat factors, while the biological and soil factors controlling soil respiration and their interactions with water and heat factors have not been considered yet. These models are not able to accurately evaluate soil respiration in different vegetation/terrestrial ecosystems at different temporal and spatial scales. Thus, a general evaluation model for soil respiration (GEMSR) including the interacting meteorological (water and heat factors), soil nutrient and biological factors is suggested in this paper, and the basic procedure developing GEMSR and the research tasks of soil respiration in the future are also discussed.
Synchronization criteria based on a general complex dynamical network model
Institute of Scientific and Technical Information of China (English)
ZHANG Jian-lin; WANG Chang-jian; XU Cong-fu
2008-01-01
Many complex dynamical networks display synchronization phenomena. We introduce a general complex dynamical network model. The model is equivalent to a simple vector model of adopting the Kronecker product. Some synchronization criteria, including time-variant networks and time-varying networks, are deduced based on Lyapunov's stability theory, and they are proven on the condition of obtaining a certain synchronous solution of an isolated cell. In particular, the inner-coupling matrix directly determines the synchronization of the time-invariant network; while for a time-varying periodic dynamical network, the asymptotic stability of a synchronous solution is determined by a constant matrix which is related to the fundamental solution matrices of the linearization system. Finally, illustrative examples are given to validate the results.
A generalized and parameterized interference model for cognitive radio networks
Mahmood, Nurul Huda
2011-06-01
For meaningful co-existence of cognitive radios with primary system, it is imperative that the cognitive radio system is aware of how much interference it generates at the primary receivers. This can be done through statistical modeling of the interference as perceived at the primary receivers. In this work, we propose a generalized model for the interference generated by a cognitive radio network, in the presence of small and large scale fading, at a primary receiver located at the origin. We then demonstrate how this model can be used to estimate the impact of cognitive radio transmission on the primary receiver in terms of different outage probabilities. Finally, our analytical findings are validated through some selected computer-based simulations. © 2011 IEEE.
Generalized self-dual Maxwell-Chern-Simons-Higgs model
Bazeia, D; da Hora, E; Menezes, R
2012-01-01
We present a consistent BPS framework for a generalized Maxwell-Chern-Simons-Higgs model. The overall model, including its self-dual potential, depends on three different functions, h(|{\\phi}|,N), w(|{\\phi}|) and G(|{\\phi}|), which are functions of the scalar fields only. The BPS energy is proportional to the magnetic flux when w(|{\\phi}|) and G(|{\\phi}|) are related to each other by a differential constraint. We present an explicit non-standard model and its topologically non-trivial static configurations, which are described by the usual radially symmetric profile. Finally, we note that the non-standard results behave in a similar way as their standard counterparts, as expected, reinforcing the consistence of the overall construction.
Generalized self-dual Maxwell-Chern-Simons-Higgs model
Bazeia, D.; Casana, R.; da Hora, E.; Menezes, R.
2012-06-01
We present a consistent Bogomol’nyi-Prasad-Sommerfield (BPS) framework for a generalized Maxwell-Chern-Simons-Higgs model. The overall model, including its self-dual potential, depends on three different functions, h(|ϕ|,N), w(|ϕ|), and G(|ϕ|), which are functions of the scalar fields only. The BPS energy is proportional to the magnetic flux when w(|ϕ|) and G(|ϕ|) are related to each other by a differential constraint. We present an explicit nonstandard model and its topologically nontrivial static configurations, which are described by the usual radially symmetric profile. Finally, we note that the nonstandard results behave in a similar way as their standard counterparts, as expected, reinforcing the consistence of the overall construction.
A General Approach to the Modelling of Trophic Chains
Dilão, R; Dilao, Rui; Domingos, Tiago
1999-01-01
Based on the law of mass action (and its microscopic foundation) and mass conservation, we present here a method to derive consistent dynamic models for the time evolution of systems with an arbitrary number of species. Equations are derived through a mechanistic description, ensuring that all parameters have ecological meaning. After discussing the biological mechanisms associated to the logistic and Lotka-Volterra equations, we show how to derive general models for trophic chains, including the effects of internal states at fast time scales. We show that conformity with the mass action law leads to different functional forms for the Lotka-Volterra and trophic chain models. We use mass conservation to recover the concept of carrying capacity for an arbitrary food chain.
Asymptotics of the QMLE for General ARCH(q) Models
DEFF Research Database (Denmark)
Kristensen, Dennis; Rahbek, Anders Christian
2009-01-01
Asymptotics of the QMLE for Non-Linear ARCH Models Dennis Kristensen, Columbia University Anders Rahbek, University of Copenhagen Abstract Asymptotic properties of the quasi-maximum likelihood estimator (QMLE) for non-linear ARCH(q) models -- including for example Asymmetric Power ARCH and log......-ARCH -- are derived. Strong consistency is established under the assumptions that the ARCH process is geometrically ergodic, the conditional variance function has a finite log-moment, and finite second moment of the rescaled error. Asymptotic normality of the estimator is established under the additional assumption...... that certain ratios involving the conditional variance function are suitably bounded, and that the rescaled errors have little more than fourth moment. We verify our general conditions, including identification, for a wide range of leading specific ARCH models....
Thermal power system analysis using a generalized network flow model
Energy Technology Data Exchange (ETDEWEB)
Kumar, John Arun [Former Senior Design Engineer, Power System Analysis and Control Group, Bharat Heavy Electricals Limited, New Delhi (India); Chebiyam, Radhakrishna [Former Director, Academic Staff College, JNT University, Hyderabad-72 (India)
2012-07-01
This paper analyzes an Integrated Thermal Power System using a Multiperiod Generalized Network Flow Model. The thermal system analysis is carried out by taking into account the complex dynamics involved in utilizing multiple energy carriers (coal, diesel and natural gas). The model comprises energy source nodes, energy transformation nodes, energy storage nodes, energy demand nodes and their interconnections. The solution to the integrated energy system problem involves the evaluation of energy flows that meet the electricity demand at minimum total cost, while satisfying system constraints. This is illustrated through the India case study using a minimum time-step of one hour. MATLAB based software was developed for carrying out this study. TOMLAB/CPLEX software was utilized for obtaining the optimal solution. The model and the methodology utilized for conducting the study would be of interest to those involved in integrated energy system planning for a country or a region.
Dimensional Reduction for the General Markov Model on Phylogenetic Trees.
Sumner, Jeremy G
2017-03-01
We present a method of dimensional reduction for the general Markov model of sequence evolution on a phylogenetic tree. We show that taking certain linear combinations of the associated random variables (site pattern counts) reduces the dimensionality of the model from exponential in the number of extant taxa, to quadratic in the number of taxa, while retaining the ability to statistically identify phylogenetic divergence events. A key feature is the identification of an invariant subspace which depends only bilinearly on the model parameters, in contrast to the usual multi-linear dependence in the full space. We discuss potential applications including the computation of split (edge) weights on phylogenetic trees from observed sequence data.
General Study of Perturbations in Bouncing and Cyclic Models
Mayes, Riley; Biswas, Tirthabir; Lattyak, Colleen
2015-04-01
Perturbations are important in both understanding and evaluating the importance of bounces and turnarounds in models that predict a cyclic evolution of our Universe. Moreover, tracking these perturbations through the entirety of the cycle is important as it provides an outlet for a qualitative comparison with Cosmic Microwave Background (CMB) observations. However, tracking these perturbations through each cycle proves difficult as the physics to describe bounces and turnarounds is not well established. Therefore, we first studied general anaytical and numerical techniques in order to understand the evolution of fluctuations in simple cosmological models where physics is better understood. In our research, we first developed analytical techniques from background solutions to establish a solid foundation for describing super-Hubble fluctuations in our early Universe. These analytical solutions were developed for both bounces and turnarounds allowing us to numerically verify and then further investigate the consequences of these solutions in models such as bounce inflation and cyclic inflation.
Toward a general evaluation model for soil respiration (GEMSR)
Institute of Scientific and Technical Information of China (English)
ZHOU GuangSheng; JIA BingRui; HAN GuangXuan; ZHOU Li
2008-01-01
Soil respiration is an important component of terrestrial carbon budget. Its accurate evaluation is essential to the study of terrestrial carbon source/sink. Studies on soil respiration at present mostly focus on the temporal variations and the controlling factors of soil respiration, but its spatial variations and controlling factors draw less attention. Moreover, the evaluation models for soil respiration at present include only the effects of water and heat factors, while the biological and soil factors controlling soil respiration and their interactions with water and heat factors have not been considered yet. These models are not able to accurately evaluate soil respiration in different vegetation/terrestrial ecosystems at different temporal and spatial scales. Thus, a general evaluation model for soil respiration (GEMSR)including the interacting meteorological (water and heat factors), soil nutrient and biological factors is suggested in this paper, and the basic procedure developing GEMSR and the research tasks of soil respiration in the future are also discussed.
Analysis of Robust Quasi-deviances for Generalized Linear Models
Directory of Open Access Journals (Sweden)
Eva Cantoni
2004-04-01
Full Text Available Generalized linear models (McCullagh and Nelder 1989 are a popular technique for modeling a large variety of continuous and discrete data. They assume that the response variables Yi , for i = 1, . . . , n, come from a distribution belonging to the exponential family, such that E[Yi ] = ?i and V[Yi ] = V (?i , and that ?i = g(?i = xiT?, where ? ? IR p is the vector of parameters, xi ? IR p, and g(. is the link function. The non-robustness of the maximum likelihood and the maximum quasi-likelihood estimators has been studied extensively in the literature. For model selection, the classical analysis-of-deviance approach shares the same bad robustness properties. To cope with this, Cantoni and Ronchetti (2001 propose a robust approach based on robust quasi-deviance functions for estimation and variable selection. We refer to that paper for a deeper discussion and the review of the literature.
A General Mechanistic Model of Solid Oxide Fuel Cells
Institute of Scientific and Technical Information of China (English)
SHI Yixiang; CAI Ningsheng
2006-01-01
A comprehensive model considering all forms of polarization was developed. The model considers the intricate interdependency among the electrode microstructure, the transport phenomena, and the electrochemical processes. The active three-phase boundary surface was expressed as a function of electrode microstructure parameters (porosity, coordination number, contact angle, etc.). The exchange current densities used in the simulation were obtained by fitting a general formulation to the polarization curves proposed as a function of cell temperature and oxygen partial pressure. A validation study shows good agreement with published experimental data. Distributions of overpotentials, gas component partial pressures, and electronic/ionic current densities have been calculated. The effects of a porous electrode structure and of various operation conditions on cell performance were also predicted. The mechanistic model proposed can be used to interpret experimental observations and optimize cell performance by incorporating reliable experimental data.
Extensive investigation of the generalized dark matter model
Kopp, Michael; Skordis, Constantinos; Thomas, Dan B.
2016-08-01
The cold dark matter (CDM) model, wherein the dark matter is treated as a pressureless perfect fluid, provides a good fit to galactic and cosmological data. With the advent of precision cosmology, it should be asked whether this simplest model needs to be extended, and whether doing so could improve our understanding of the properties of dark matter. One established parametrization for generalizing the CDM fluid is the generalized dark matter (GDM) model, in which dark matter is an imperfect fluid with pressure and shear viscosity that fulfill certain postulated closure equations. We investigate these closure equations and the three new parametric functions they contain: the background equation of state w , the speed of sound cs2 and the viscosity cvis2. Taking these functions to be constant parameters, we analyze an exact solution of the perturbed Einstein equations in a flat GDM-dominated universe and discuss the main effects of the three parameters on the cosmic microwave background (CMB). Our analysis suggests that the CMB alone is not able to distinguish between the GDM sound speed and viscosity parameters, but that other observables, such as the matter power spectrum, are required to break this degeneracy. In order to elucidate further the meaning of the GDM closure equations, we also consider other descriptions of imperfect fluids that have a nonperturbative definition and relate these to the GDM model. In particular, we consider scalar fields, an effective field theory (EFT) of fluids, an EFT of large-scale structure, nonequilibrium thermodynamics and tightly coupled fluids. These descriptions could be used to extend the GDM model into the nonlinear regime of structure formation, which is necessary if the wealth of data available on those scales is to be employed in constraining the model. We also derive the initial conditions for adiabatic and isocurvature perturbations in the presence of GDM and standard cosmological fluids and provide the result in a
A Global Ocean Biogeochemistry General Circulation Model and its Simulations
Institute of Scientific and Technical Information of China (English)
XU Yongfu; LI Yangchun; CHU Min
2013-01-01
An ocean biogeochemistry model was developed and incorporated into a global ocean general circulation model (LICOM) to form an ocean biogeochemistry general circulation model (OBGCM).The model was used to study the natural carbon cycle and the uptake and storage of anthropogenic CO2 in the ocean.A global export production of 12.5 Pg C yr-1 was obtained.The model estimated that in the pre-industrial era the global equatorial region within ±15° of the equator released 0.97 Pg C yr-1 to the atmosphere,which was balanced by the gain of CO2 in other regions.The post-industrial air-sea CO2 flux indicated the oceanic uptake of CO2 emitted by human activities.An increase of 20-50 μmol kg-1 for surface dissolved inorganic carbon (DIC) concentrations in the 1990s relative to pre-industrial times was obtained in the simulation,which was consistent with data-based estimates.The model generated a total anthropogenic carbon inventory of 105 Pg C as of 1994,which was within the range of estimates by other researchers.Various transports of both natural and anthropogenic DIC as well as labile dissolved organic carbon (LDOC)were estimated from the simulation.It was realized that the Southern Ocean and the high-latitude region of the North Pacific are important export regions where accumulative air-sea CO2 fluxes are larger than the DIC inventory,whereas the subtropical regions are acceptance regions.The interhemispheric transport of total natural carbon (DIC+LDOC) was found to be northward (0.11 Pg C yr-1),which was just balanced by the gain of carbon from the atmosphere in the Southern Hemisphere.
Generalized Stefan models accounting for a discontinuous temperature field
Danescu, A.
We construct a class of generalized Stefan models able to account for a discontinuous temperature field across a nonmaterial interface. The resulting theory introduces a constitutive scalar interfacial field, denoted by /lineθ and called the equivalent temperature of the interface. A classical procedure, based on the interfacial dissipation inequality, relates the interfacial energy release to the interfacial mass flux and restricts the equivalent temperature of the interface. We show that previously proposed theories are obtained as particular cases when /lineθ = ⪉θ > or /lineθ = ⪉(1)/(θ )>-1 or, more generally, when /lineθ = ⪉θ r ⪉ 1/θ1-r-1 for 0<= r<= 1. We study in a particular constitutive framework the solidification of an under-cooled liquid and we are able to give a sufficient condition for the existence of travelling wave solutions.
Mathematical model and general laws of wet compression
Institute of Scientific and Technical Information of China (English)
王永青; 刘铭; 廉乐明; 何健勇; 严家騄
2002-01-01
Wet compression is an effective way to enhance the performance of gas turbines and it has attracted a good deal of attention in recent years. The one-sidedness and inaccuracy of previous studies,which took concentration gradient as mass transfer potential are discussed. The mass transfer process is analyzed from the viewpoint of non-equilibrium thermodynamics,by taking generalized thermodynamic driving force as mass transfer potential,and the corresponding mass-transfer coefficient is obtained using the heat and mass transfer equilibrium occurring between moist air and water droplets at wet-bulb temperature for the sake of avoiding complex tests and providing more accurate formulas. A mathematical model of wet compression is therefore established,and the general laws of wet compression are investigated. The results show that the performance of atomizer is critical for wet compression and wet compression is more suitable for compressors with higher pressure ratio and longer compression time.
General business model patterns for Local Energy Management concepts
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Emanuele eFacchinetti
2016-03-01
Full Text Available The transition towards a more sustainable global energy system, significantly relying on renewable energies and decentralized energy systems, requires a deep reorganization of the energy sector. The way how energy services are generated, delivered and traded is expected to be very different in the coming years. Business model innovation is recognized as a key driver for the successful implementation of the energy turnaround. This work contributes to this topic by introducing a heuristic methodology easing the identification of general business model patterns best suited for Local Energy Management concepts such as Energy Hubs. A conceptual framework characterizing the Local Energy Management business model solution space is developed. Three reference business model patterns providing orientation across the defined solution space are identified, analyzed and compared. Through a market review a number of successfully implemented innovative business models have been analyzed and allocated within the defined solution space. The outcomes of this work offer to potential stakeholders a starting point and guidelines for the business model innovation process, as well as insights for policy makers on challenges and opportunities related to Local Energy Management concepts.
Generalized fish life-cycle poplulation model and computer program
Energy Technology Data Exchange (ETDEWEB)
DeAngelis, D. L.; Van Winkle, W.; Christensen, S. W.; Blum, S. R.; Kirk, B. L.; Rust, B. W.; Ross, C.
1978-03-01
A generalized fish life-cycle population model and computer program have been prepared to evaluate the long-term effect of changes in mortality in age class 0. The general question concerns what happens to a fishery when density-independent sources of mortality are introduced that act on age class 0, particularly entrainment and impingement at power plants. This paper discusses the model formulation and computer program, including sample results. The population model consists of a system of difference equations involving age-dependent fecundity and survival. The fecundity for each age class is assumed to be a function of both the fraction of females sexually mature and the weight of females as they enter each age class. Natural mortality for age classes 1 and older is assumed to be independent of population size. Fishing mortality is assumed to vary with the number and weight of fish available to the fishery. Age class 0 is divided into six life stages. The probability of survival for age class 0 is estimated considering both density-independent mortality (natural and power plant) and density-dependent mortality for each life stage. Two types of density-dependent mortality are included. These are cannibalism of each life stage by older age classes and intra-life-stage competition.
Generalized Magnetic Field Effects in Burgers' Nanofluid Model
Rashidi, M. M.; Yang, Z.; Awais, Muhammad; Nawaz, Maria; Hayat, Tasawar
2017-01-01
Analysis has been conducted to present the generalized magnetic field effects on the flow of a Burgers' nanofluid over an inclined wall. Mathematical modelling for hydro-magnetics reveals that the term “σB02u/ρ” is for the Newtonian model whereas the generalized magnetic field term (as mentioned in Eq 4) is for the Burgers’ model which is incorporated in the current analysis to get the real insight of the problem for hydro-magnetics. Brownian motion and thermophoresis phenomenon are presented to analyze the nanofluidics for the non-Newtonian fluid. Mathematical analysis is completed in the presence of non-uniform heat generation/absorption. The constructed set of partial differential system is converted into coupled nonlinear ordinary differential system by employing the suitable transformations. Homotopy approach is employed to construct the analytical solutions which are shown graphically for sundr5y parameters including Deborah numbers, magnetic field, thermophoresis, Brownian motion and non-uniform heat generation/absorption. A comparative study is also presented showing the comparison of present results with an already published data. PMID:28045965
A message passing approach for general epidemic models
Karrer, Brian
2010-01-01
In most models of the spread of disease over contact networks it is assumed that the probabilities of disease transmission and recovery from disease are constant in time. In real life, however, this is far from true. In many diseases, for instance, recovery occurs at about the same time after infection for all individuals, rather than at a constant rate. In this paper, we study a generalized version of the SIR (susceptible-infected-recovered) model of epidemic disease that allows for arbitrary nonuniform distributions of transmission and recovery times. Standard differential equation approaches cannot be used for this generalized model, but we show that the problem can be reformulated as a time-dependent message passing calculation on the appropriate contact network. The calculation is exact on trees (i.e., loopless networks) or locally tree-like networks (such as random graphs) in the large system size limit. On non-tree-like networks we show that the calculation gives a rigorous bound on the size of disease...
Analysis of male reproductive parameters in a murine model of mucopolysaccharidosis type I (MPS I).
do Nascimento, Cinthia Castro; Junior, Odair Aguiar; D'Almeida, Vânia
2014-01-01
Mucopolysaccharidosis (MPS) I is a lysosomal storage disorder (LSD) that is characterised by alpha-L-iduronidase (Idua) deficiency and continuous deposition of glycosaminoglycans (GAGs), which consequently interferes with cell signalling mechanisms and results in multisystemic and progressive symptoms. The animal model of MPS I (Idua-/-) has been widely studied to elucidate the consequences and progression of the disorder; however, studies specifically assessing the male reproductive tract are lacking. The aim of this study was to evaluate some of the reproductive characteristics of male MPS I mice in two phases of life. Reproductive organ biometry, sperm counts, sperm morphological evaluation, plasma testosterone measurements and histopathological, histomorphometrical and immunohistochemical analysis were performed in 3- and 6-month-old C57BL/6 Idua+/+ and Idua-/- mice. Seminal vesicle weights were decreased in both the 3- and 6-month-old Idua-/- mice. Decrease in sperm counts and the majority of the histopathological signs were observed in the 6-month-old Idua-/- mice. No differences were detected in the sperm morphological analysis. Immunohistochemistry revealed that seminiferous tubules from 3-month-old Idua-/- mice were more intensely stained with anti-caspase-3 than 3-month-old Idua+/+ mice, but no difference was found at 6 months. These results suggest that MPS I interferes with male reproductive parameters both in 3 and 6-month-old animals and histopathological signs are more pronounced in 6-month-old mice, indicating that the effects of the disorder may intensify with the disease progression.
Korsgaard, B
2006-07-01
In the present experiment male and female eelpout, Zoarces viviparus were exposed to different doses of the model androgen 17alpha-methyltestosterone (MT) and the effects on the plasma level of vitellogenin and the gonadosomatic index were investigated. In females exposed to different doses of MT (nominal concentrations 10, 25, 50, 100 and 500 ng/L) in the ambient seawater, the concentrations of the circulating yolk-precursor protein vitellogenin (vtg) were shown to decrease in all groups but only significantly in the MT-100 group when compared to controls. No significant effects could be observed on the GSI during early vitellogenesis (April/May). Males exposed to E2 under flow through conditions during 10 days showed an induced synthesis of vtg as depicted by a high level of circulating vtg. When the estrogen-exposed males were subsequently exposed to different doses of MT only, during another 10 days, the levels of vtg decreased significantly in three of the MT-treated groups when compared with the level of vtg in plasma of the estrogen-treated group after the first 10 days. The gonadosomatic index was observed to decrease by the estradiol-treatment but to increase in a dose-dependent manner in the MT-exposed groups, indicating that MT had the capacity to override the effect of the preceding exposure to estradiol-17beta.
Modeling predictors of risky drug use behavior among male street laborers in urban Vietnam.
Nguyen, Van Huy; Dunne, Michael P; Debattista, Joseph
2013-05-07
The application of theoretical frameworks for modeling predictors of drug risk among male street laborers remains limited. The objective of this study was to test a modified version of the IMB (Information-Motivation-Behavioral Skills Model), which includes psychosocial stress, and compare this modified version with the original IMB model in terms of goodness-of-fit to predict risky drug use behavior among this population. In a cross-sectional study, social mapping technique was conducted to recruit 450 male street laborers from 135 street venues across 13 districts of Hanoi city, Vietnam, for face-to-face interviews. Structural equation modeling (SEM) was used to analyze data from interviews. Overall measures of fit via SEM indicated that the original IMB model provided a better fit to the data than the modified version. Although the former model was able to predict a lesser variance than the latter (55% vs. 62%), it was of better fit. The findings suggest that men who are better informed and motivated for HIV prevention are more likely to report higher behavioral skills, which, in turn, are less likely to be engaged in risky drug use behavior. This was the first application of the modified IMB model for drug use in men who were unskilled, unregistered laborers in urban settings. An AIDS prevention program for these men should not only distribute information and enhance motivations for HIV prevention, but consider interventions that could improve self-efficacy for preventing HIV infection. Future public health research and action may also consider broader factors such as structural social capital and social policy to alter the conditions that drive risky drug use among these men.
A seasonal model of the Mediterranean Sea general circulation
Roussenov, Vassil; Stanev, Emil; Artale, Vincenzo; Pinardi, Nadia
1995-07-01
This paper describes the seasonal characteristics of the Mediterranean Sea general circulation as simulated by a primitive equation general circulation model. The forcing is composed of climatological monthly mean atmospheric parameters, which are used to compute the heat and momentum budgets at the air-sea interface of the model. This allows heat fluxes to be determined by a realistic air-sea interaction physics. The Strait of Gibraltar is open, and the model resolution is ? in the horizontal and 19 levels in the vertical. The results show the large seasonal cycle of the circulation and its transient characteristics. The heat budget at the surface is characterized by lateral boundary intensifications occurring in downwelling and up welling areas of the basin. The general circulation is composed of subbasin gyres, and cyclonic motion dominates the northern and anticyclonic motion the southern part of the basin. The Atlantic stream which enters from Gibraltar and assumes the form of different boundary current subsystems is a coherent structure at the surface. At depth it appears as current segments and jets around a vigorous gyre system. The seasonal variability is manifested not only by a change in amplitude and location of the gyres but also by the appearance of seasonally recurrent gyres in different parts of the basin. Distinct westward propagation of these gyres occurs, together with amplitude changes. For the first time a Mersa-Matruh Gyre is successfully simulated due to the introduction of our heat fluxes at the air-sea interface. The seasonal thermocline is formed each summer, and a deep winter mixed layer is produced in the region of Levantine intermediate water formation. Deep water renewal does not occur, probably due to the climatological forcing used.
A GENERALIZATION OF TRADITIONAL KANO MODEL FOR CUSTOMER REQUIREMENTS ANALYSIS
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Renáta Turisová
2015-07-01
Full Text Available Purpose: The theory of attractiveness determines the relationship between the technically achieved and customer perceived quality of product attributes. The most frequently used approach in the theory of attractiveness is the implementation of Kano‘s model. There exist a lot of generalizations of that model which take into consideration various aspects and approaches focused on understanding the customer preferences and identification of his priorities for a selling product. The aim of this article is to outline another possible generalization of Kano‘s model.Methodology/Approach: The traditional Kano’s model captures the nonlinear relationship between reached attributes of quality and customer requirements. The individual attributes of quality are divided into three main categories: must-be, one-dimensional, attractive quality and into two side categories: indifferent and reverse quality. The well selling product has to contain the must-be attribute. It should contain as many one-dimensional attributes as possible. If there are also supplementary attractive attributes, it means that attractiveness of the entire product, from the viewpoint of the customer, nonlinearly sharply rises what has a direct positive impact on a decision of potential customer when purchasing the product. In this article, we show that inclusion of individual quality attributes of a product to the mentioned categories depends, among other things, also on costs on life cycle of the product, respectively on a price of the product on the market.Findings: In practice, we are often encountering the inclusion of products into different price categories: lower, middle and upper class. For a certain type of products the category is either directly declared by a producer (especially in automotive industry, or is determined by a customer by means of assessment of available market prices. To each of those groups of a products different customer expectations can be assigned
Directory of Open Access Journals (Sweden)
Katharine Kripke
Full Text Available Uganda aims to provide safe male circumcision (SMC to 80% of men ages 15-49 by 2016. To date, only 2 million men have received SMC of the 4.2 million men required. In response to age and regional trends in SMC uptake, the country sought to re-examine its targets with respect to age and subnational region, to assess the program's progress, and to refine the implementation approach.The Decision Makers' Program Planning Tool, Version 2.0 (DMPPT 2.0, was used in conjunction with incidence projections from the Spectrum/AIDS Impact Module (AIM to conduct this analysis. Population, births, deaths, and HIV incidence and prevalence were used to populate the model. Baseline male circumcision prevalence was derived from the 2011 AIDS Indicator Survey. Uganda can achieve the most immediate impact on HIV incidence by circumcising men ages 20-34. This group will also require the fewest circumcisions for each HIV infection averted. Focusing on men ages 10-19 will offer the greatest impact over a 15-year period, while focusing on men ages 15-34 offers the most cost-effective strategy over the same period. A regional analysis showed little variation in cost-effectiveness of scaling up SMC across eight regions. Scale-up is cost-saving in all regions. There is geographic variability in program progress, highlighting two regions with low baseline rates of circumcision where additional efforts will be needed.Focusing SMC efforts on specific age groups and regions may help to accelerate Uganda's SMC program progress. Policy makers in Uganda have already used model outputs in planning efforts, proposing males ages 10-34 as a priority group for SMC in the 2014 application to the Global Fund's new funding model. As scale-up continues, the country should also consider a greater effort to expand SMC in regions with low MC prevalence.
A General Random Walk Model of Molecular Motor
Institute of Scientific and Technical Information of China (English)
WANG Xian-Ju; AI Bao-Quan; LIU Guo-Tao; LIU Liang-Gang
2003-01-01
A general random walk model framework is presented which can be used to statistically describe the internaldynamics and external mechanical movement of molecular motors along filament track. The motion of molecular motorin a periodic potential and a constant force is considered. We show that the molecular motor's movement becomesslower with the potential barrier increasing, but if the forceis increased, the molecular motor's movement becomesfaster. The relation between the effective rate constant and the potential barrier's height, and that between the effectiverate constant and the value of the force are discussed. Our results are consistent with the experiments and relevanttheoretical consideration, and can be used to explain some physiological phenomena.
Estimation and variable selection for generalized additive partial linear models
Wang, Li
2011-08-01
We study generalized additive partial linear models, proposing the use of polynomial spline smoothing for estimation of nonparametric functions, and deriving quasi-likelihood based estimators for the linear parameters. We establish asymptotic normality for the estimators of the parametric components. The procedure avoids solving large systems of equations as in kernel-based procedures and thus results in gains in computational simplicity. We further develop a class of variable selection procedures for the linear parameters by employing a nonconcave penalized quasi-likelihood, which is shown to have an asymptotic oracle property. Monte Carlo simulations and an empirical example are presented for illustration. © Institute of Mathematical Statistics, 2011.
Consolidation of data base for Army generalized missile model
Klenke, D. J.; Hemsch, M. J.
1980-01-01
Data from plume interaction tests, nose mounted canard configuration tests, and high angle of attack tests on the Army Generalized Missile model are consolidated in a computer program which makes them readily accessible for plotting, listing, and evaluation. The program is written in FORTRAN and will run on an ordinary minicomputer. It has the capability of retrieving any coefficient from the existing DATAMAN tapes and displaying it in tabular or plotted form. Comparisons of data taken in several wind tunnels and of data with the predictions of Program MISSILE2 are also presented.
Adaptive quasi-likelihood estimate in generalized linear models
Institute of Scientific and Technical Information of China (English)
CHEN Xia; CHEN Xiru
2005-01-01
This paper gives a thorough theoretical treatment on the adaptive quasilikelihood estimate of the parameters in the generalized linear models. The unknown covariance matrix of the response variable is estimated by the sample. It is shown that the adaptive estimator defined in this paper is asymptotically most efficient in the sense that it is asymptotic normal, and the covariance matrix of the limit distribution coincides with the one for the quasi-likelihood estimator for the case that the covariance matrix of the response variable is completely known.
An Optimal Capacity Planning Model for General Cargo Seaport
Directory of Open Access Journals (Sweden)
Čedomir Dundović
2012-10-01
Full Text Available In this paper the application of the queuing the01y in optimalcapacity planning for general cargo seaport is presented.The seaport as a queuing syslem is defined and tlws, on the basisof the arrival and serviced number of ships in an obsen•edtime unit, the appropriate operating indicators of a port systemare calculated. Using the model of total port costs, the munberof berths and cranes on the berth can be determined wherebythe optimal port system functioning is achieved.
Gauge Potts model with generalized action: A Monte Carlo analysis
Energy Technology Data Exchange (ETDEWEB)
Fanchiotti, H.; Canal, C.A.G.; Sciutto, S.J.
1985-08-15
Results of a Monte Carlo calculation on the q-state gauge Potts model in d dimensions with a generalized action involving planar 1 x 1, plaquette, and 2 x 1, fenetre, loop interactions are reported. For d = 3 and q = 2, first- and second-order phase transitions are detected. The phase diagram for q = 3 presents only first-order phase transitions. For d = 2, a comparison with analytical results is made. Here also, the behavior of the numerical simulation in the vicinity of a second-order transition is analyzed.
A generalized methodology to characterize composite materials for pyrolysis models
McKinnon, Mark B.
The predictive capabilities of computational fire models have improved in recent years such that models have become an integral part of many research efforts. Models improve the understanding of the fire risk of materials and may decrease the number of expensive experiments required to assess the fire hazard of a specific material or designed space. A critical component of a predictive fire model is the pyrolysis sub-model that provides a mathematical representation of the rate of gaseous fuel production from condensed phase fuels given a heat flux incident to the material surface. The modern, comprehensive pyrolysis sub-models that are common today require the definition of many model parameters to accurately represent the physical description of materials that are ubiquitous in the built environment. Coupled with the increase in the number of parameters required to accurately represent the pyrolysis of materials is the increasing prevalence in the built environment of engineered composite materials that have never been measured or modeled. The motivation behind this project is to develop a systematic, generalized methodology to determine the requisite parameters to generate pyrolysis models with predictive capabilities for layered composite materials that are common in industrial and commercial applications. This methodology has been applied to four common composites in this work that exhibit a range of material structures and component materials. The methodology utilizes a multi-scale experimental approach in which each test is designed to isolate and determine a specific subset of the parameters required to define a material in the model. Data collected in simultaneous thermogravimetry and differential scanning calorimetry experiments were analyzed to determine the reaction kinetics, thermodynamic properties, and energetics of decomposition for each component of the composite. Data collected in microscale combustion calorimetry experiments were analyzed to
Estimating parameters for generalized mass action models with connectivity information
Directory of Open Access Journals (Sweden)
Voit Eberhard O
2009-05-01
Full Text Available Abstract Background Determining the parameters of a mathematical model from quantitative measurements is the main bottleneck of modelling biological systems. Parameter values can be estimated from steady-state data or from dynamic data. The nature of suitable data for these two types of estimation is rather different. For instance, estimations of parameter values in pathway models, such as kinetic orders, rate constants, flux control coefficients or elasticities, from steady-state data are generally based on experiments that measure how a biochemical system responds to small perturbations around the steady state. In contrast, parameter estimation from dynamic data requires time series measurements for all dependent variables. Almost no literature has so far discussed the combined use of both steady-state and transient data for estimating parameter values of biochemical systems. Results In this study we introduce a constrained optimization method for estimating parameter values of biochemical pathway models using steady-state information and transient measurements. The constraints are derived from the flux connectivity relationships of the system at the steady state. Two case studies demonstrate the estimation results with and without flux connectivity constraints. The unconstrained optimal estimates from dynamic data may fit the experiments well, but they do not necessarily maintain the connectivity relationships. As a consequence, individual fluxes may be misrepresented, which may cause problems in later extrapolations. By contrast, the constrained estimation accounting for flux connectivity information reduces this misrepresentation and thereby yields improved model parameters. Conclusion The method combines transient metabolic profiles and steady-state information and leads to the formulation of an inverse parameter estimation task as a constrained optimization problem. Parameter estimation and model selection are simultaneously carried out
Mu, Li; Geng, Li-Cheng; Xu, Hui; Luo, Man; Geng, Jing-Miao; Li, Li
2017-04-01
Urethral catheterization is a predictor of agitation during the general anesthesia recovery period. The aim of this study was to determine the effect of intraurethral 5% lidocaine and 25 mg/g prilocaine cream in reducing catheter-related bladder discomfort (CRBD) in male patients during the general anesthesia recovery period. Adult male patients undergoing elective operations that required urinary catheterization under general anesthesia were enrolled and assigned randomly to 2 groups. In the lidocaine-prilocaine cream group (n = 72), approximately 5 g of topical cream was spread in the preputial sac, the glans, the meatus, and on the urinary catheter surface before urinary catheterization. In the control group (n = 74), the urinary catheter was lubricated with lidocaine gel. The incidence and severity of CRBD were assessed 15, 30, 45, and 60 minutes postoperatively. We found that the incidence of CRBD in the lidocaine-prilocaine cream group was significantly lower than in the control group. Multivariate logistic regression analysis showed that lidocaine-prilocaine cream applications reduced moderate or severe CRBD. Thirty minutes postoperation was the most frequent time point for the incidence of CRBD. Application of lidocaine-prilocaine cream on the surface of the urinary catheter is an efficient and safe method to reduce the incidence and severity of CRBD.
Optimizing a Male Reproductive Aging Mouse Model by d-Galactose Injection
Directory of Open Access Journals (Sweden)
Chun-Hou Liao
2016-01-01
Full Text Available The d-galactose (d-gal-injected animal model, which is typically established by administering consecutive subcutaneous d-gal injections to animals for approximately six or eight weeks, has been frequently used for aging research. In addition, this animal model has been demonstrated to accelerate aging in the brain, kidneys, liver and blood cells. However, studies on aging in male reproductive organs that have used this animal model remain few. Therefore, the current study aimed to optimize a model of male reproductive aging by administering d-gal injections to male mice and to determine the possible mechanism expediting senescence processes during spermatogenesis. In this study, C57Bl/6 mice were randomized into five groups (each containing 8–10 mice according to the daily intraperitoneal injection of vehicle control or 100 or 200 mg/kg dosages of d-gal for a period of six or eight weeks. First, mice subjected to d-gal injections for six or eight weeks demonstrated considerably decreased superoxide dismutase activity in the serum and testis lysates compared to those in the control group. The lipid peroxidation in testis also increased in the d-gal-injected groups. Furthermore, the d-gal-injected groups exhibited a decreased ratio of testis weight/body weight and sperm count compared to the control group. The percentages of both immotile sperm and abnormal sperm increased considerably in the d-gal-injected groups compared to those of the control group. To determine the genes influenced by the d-gal injection during murine spermatogenesis, a c-DNA microarray was conducted to compare testicular RNA samples between the treated groups and the control group. The d-gal-injected groups exhibited RNA transcripts of nine spermatogenesis-related genes (Cycl2, Hk1, Pltp, Utp3, Cabyr, Zpbp2, Speer2, Csnka2ip and Katnb1 that were up- or down-regulated by at least two-fold compared to the control group. Several of these genes are critical for forming sperm
Heterosexual male perpetrators of childhood sexual abuse: a preliminary neuropsychiatric model.
Cohen, Lisa J; Nikiforov, Konstantin; Gans, Sniezyna; Poznansky, Olga; McGeoch, Pamela; Weaver, Carrie; King, Enid Gertmanian; Cullen, Ken; Galynker, Igor
2002-01-01
This paper presents data from a series of preliminary neuropsychiatric studies, including neuropsychological, personality, sexual history, plethysmographic and neuroimaging investigations, on a sample of 22 male, heterosexual, nonexclusive pedophiles and 24 demographically similar healthy controls. A psychobiological model of pedophilia is proposed, positing that early childhood sexual abuse leads to neurodevelopmental abnormalities in the temporal regions mediating sexual arousal and erotic discrimination and the frontal regions mediating the cognitive aspects of sexual desire and behavioral inhibition. In this way, pedophiles develop deviant pedophilic arousal. Subsequently, if there is comorbid personality pathology, specifically sociopathy and cognitive distortions, there will be failure to inhibit pedophilic behavior.
Generalization Technique for 2D+SCALE Dhe Data Model
Karim, Hairi; Rahman, Alias Abdul; Boguslawski, Pawel
2016-10-01
Different users or applications need different scale model especially in computer application such as game visualization and GIS modelling. Some issues has been raised on fulfilling GIS requirement of retaining the details while minimizing the redundancy of the scale datasets. Previous researchers suggested and attempted to add another dimension such as scale or/and time into a 3D model, but the implementation of scale dimension faces some problems due to the limitations and availability of data structures and data models. Nowadays, various data structures and data models have been proposed to support variety of applications and dimensionality but lack research works has been conducted in terms of supporting scale dimension. Generally, the Dual Half Edge (DHE) data structure was designed to work with any perfect 3D spatial object such as buildings. In this paper, we attempt to expand the capability of the DHE data structure toward integration with scale dimension. The description of the concept and implementation of generating 3D-scale (2D spatial + scale dimension) for the DHE data structure forms the major discussion of this paper. We strongly believed some advantages such as local modification and topological element (navigation, query and semantic information) in scale dimension could be used for the future 3D-scale applications.
Computable general equilibrium model fiscal year 2013 capability development report
Energy Technology Data Exchange (ETDEWEB)
Edwards, Brian Keith [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rivera, Michael Kelly [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Boero, Riccardo [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
2016-05-17
This report documents progress made on continued developments of the National Infrastructure Simulation and Analysis Center (NISAC) Computable General Equilibrium Model (NCGEM), developed in fiscal year 2012. In fiscal year 2013, NISAC the treatment of the labor market and tests performed with the model to examine the properties of the solutions computed by the model. To examine these, developers conducted a series of 20 simulations for 20 U.S. States. Each of these simulations compared an economic baseline simulation with an alternative simulation that assumed a 20-percent reduction in overall factor productivity in the manufacturing industries of each State. Differences in the simulation results between the baseline and alternative simulations capture the economic impact of the reduction in factor productivity. While not every State is affected in precisely the same way, the reduction in manufacturing industry productivity negatively affects the manufacturing industries in each State to an extent proportional to the reduction in overall factor productivity. Moreover, overall economic activity decreases when manufacturing sector productivity is reduced. Developers ran two additional simulations: (1) a version of the model for the State of Michigan, with manufacturing divided into two sub-industries (automobile and other vehicle manufacturing as one sub-industry and the rest of manufacturing as the other subindustry); and (2) a version of the model for the United States, divided into 30 industries. NISAC conducted these simulations to illustrate the flexibility of industry definitions in NCGEM and to examine the simulation properties of in more detail.
General review on in vitro hepatocyte models and their applications.
Guguen-Guillouzo, Christiane; Guillouzo, Andre
2010-01-01
In vitro hepatocyte models represent very useful systems in both fundamental research and various application areas. Primary hepatocytes appear as the closest model for the liver in vivo. However, they are phenotypically unstable, have a limited life span and in addition, exhibit large interdonor variability when of human origin. Hepatoma cell lines appear as an alternative but only the HepaRG cell line exhibits various functions, including major cytochrome P450 activities, at levels close to those found in primary hepatocytes. In vitro hepatocyte models have brought a substantial contribution to the understanding of the biochemistry, physiology, and cell biology of the normal and diseased liver and in various application domains such as xenobiotic metabolism and toxicity, virology, parasitology, and more generally cell therapies. In the future, new well-differentiated hepatocyte cell lines derived from tumors or from either embryonic or adult stem cells might be expected and although hepatocytes will continue to be used in various fields, these in vitro liver models should allow marked advances, especially in cell-based therapies and predictive and mechanistic hepatotoxicity of new drugs and other chemicals. All models will benefit from new developments in throughput screening based on cell chips coupled with high-content imaging and in toxicogenomics technologies.
Kamran, Sultan Mehmood; Iftikhar, Raheel; Khan, Amjad; Altaf, Muhammad
2014-04-01
To compare the presence of coronary artery disease risk factors in patients with abdominal obesity versus generalised obesity and to determine the probability of developing the disease in both groups. The cross-sectional study was carried out at the Department of Medicine, Combined Military Hospital, Okara, from January 2012 to April 2013. Using consecutive sampling, 785 outdoor healthy adult males were enrolled. Body mass index > 25kg/m2 and waist circumference > 90cm defined obesity and abdominal obesity respectively. Blood pressure > 140/90mmHg defined Hypertension. All the subjects underwent BSF, electrocardiogram, Lipid profile, personality and physical activity assessment. Risk estimation was done using Eric Brittain scoring system. Data was analysed using SPSS 16. In patients with abdominal obesity, 583 (99.2%) individuals had at least 1 risk factor for coronary artery disease, while in those with generalised obesity this prevalence was 96.5% (n = 191). In patients with abdominal obesity, 52.9% had more than 4% risk of developing the disease in the next 6 years compared to 36.9% individuals with generalised obesity. Both increasing body mass index and waist circumference are associated with increased risk of developing coronary artery disease, with significantly higher risk prevalence in the latter group. Moreover, those with abdominal obesity had a higher risk of developing CAD in next 6 years as compared to those with generalised obesity. Thus waist circumference offers additional prognostic information beyond body mass index.
Modeling of Testability Requirement Based on Generalized Stochastic Petri Nets
Institute of Scientific and Technical Information of China (English)
SU Yong-ding; QIU Jing; LIU Guan-jun; QIAN Yan-ling
2009-01-01
Testability design is an effective way to realize the fault detection and isolation. Its important step is to determine testability figures of merits (TFOM). Firstly, some influence factors for TFOMs are analyzed, such as the processes of system operation, maintenance and support, fault detection and isolation and so on. Secondly, a testability requirement analysis model is built based on generalized stochastic Petri net (GSPN). Then, the system's reachable states are analyzed based on the model, a Markov chain isomorphic with Petri net is constructed, a state transition matrix is created and the system's steady state probability is obtained. The relationship between the steady state availability and testability parameters can be revealed and reasoned. Finally, an example shows that the proposed method can determine TFOM, such as fault detection rate and fault isolation rate, effectively and reasonably.
A Chemical Containment Model for the General Purpose Work Station
Flippen, Alexis A.; Schmidt, Gregory K.
1994-01-01
Contamination control is a critical safety requirement imposed on experiments flying on board the Spacelab. The General Purpose Work Station, a Spacelab support facility used for life sciences space flight experiments, is designed to remove volatile compounds from its internal airpath and thereby minimize contamination of the Spacelab. This is accomplished through the use of a large, multi-stage filter known as the Trace Contaminant Control System. Many experiments planned for the Spacelab require the use of toxic, volatile fixatives in order to preserve specimens prior to postflight analysis. The NASA-Ames Research Center SLS-2 payload, in particular, necessitated the use of several toxic, volatile compounds in order to accomplish the many inflight experiment objectives of this mission. A model was developed based on earlier theories and calculations which provides conservative predictions of the resultant concentrations of these compounds given various spill scenarios. This paper describes the development and application of this model.
On the thermodynamic properties of the generalized Gaussian core model
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B.M.Mladek
2005-01-01
Full Text Available We present results of a systematic investigation of the properties of the generalized Gaussian core model of index n. The potential of this system interpolates via the index n between the potential of the Gaussian core model and the penetrable sphere system, thereby varying the steepness of the repulsion. We have used both conventional and self-consistent liquid state theories to calculate the structural and thermodynamic properties of the system; reference data are provided by computer simulations. The results indicate that the concept of self-consistency becomes indispensable to guarantee excellent agreement with simulation data; in particular, structural consistency (in our approach taken into account via the zero separation theorem is obviously a very important requirement. Simulation results for the dimensionless equation of state, β P / ρ, indicate that for an index-value of 4, a clustering transition, possibly into a structurally ordered phase might set in as the system is compressed.
Explicit estimating equations for semiparametric generalized linear latent variable models
Ma, Yanyuan
2010-07-05
We study generalized linear latent variable models without requiring a distributional assumption of the latent variables. Using a geometric approach, we derive consistent semiparametric estimators. We demonstrate that these models have a property which is similar to that of a sufficient complete statistic, which enables us to simplify the estimating procedure and explicitly to formulate the semiparametric estimating equations. We further show that the explicit estimators have the usual root n consistency and asymptotic normality. We explain the computational implementation of our method and illustrate the numerical performance of the estimators in finite sample situations via extensive simulation studies. The advantage of our estimators over the existing likelihood approach is also shown via numerical comparison. We employ the method to analyse a real data example from economics. © 2010 Royal Statistical Society.
Confidence Intervals of Variance Functions in Generalized Linear Model
Institute of Scientific and Technical Information of China (English)
Yong Zhou; Dao-ji Li
2006-01-01
In this paper we introduce an appealing nonparametric method for estimating variance and conditional variance functions in generalized linear models (GLMs), when designs are fixed points and random variables respectively. Bias-corrected confidence bands are proposed for the (conditional) variance by local linear smoothers. Nonparametric techniques are developed in deriving the bias-corrected confidence intervals of the (conditional) variance. The asymptotic distribution of the proposed estimator is established and show that the bias-corrected confidence bands asymptotically have the correct coverage properties. A small simulation is performed when unknown regression parameter is estimated by nonparametric quasi-likelihood. The results are also applicable to nonparametric autoregressive times series model with heteroscedastic conditional variance.
Entanglement in a generalized Jaynes-Cummings model
Institute of Scientific and Technical Information of China (English)
Zhang Guo-Feng; Liu Jia
2007-01-01
We investigate the pairwise entanglement and global entanglement in a generalized Jaynes-Cummings model,which can be used to realize Greenberger-Horne-Zeilinger (GHZ) entangled state (Zheng S B 2001 Phys. Rev. Lett. 87230404). Our results show that the W-type entangled states cannot be generated based on the model. The dependences of entanglement on Rabi frequency λ and dipole-dipole coupling strength Ω are given. It is found that there exists the quantum phase transition when λ = Ω. For typical experimental data, the critical temperature for pairwise entanglement is on the order of 10-6 K. Based on these results, two strategies that overcome decoherence are proposed.
Relaxation of polymers modeled by generalized Husimi cacti
Galiceanu, M.
2010-07-01
We focus on the generalized Husimi cacti, which are dual structures to the dendrimers but, distinct from the latter, contain loops. We determine their complete spectra by making use of the normal mode analysis. These spectra have been used in computing some physical quantities, such as the averaged monomer displacement and the mechanical relaxation moduli with its two components: the storage and the loss modulus. We also study the dynamics of Husimi cacti in solutions, introducing the hydrodynamic interactions in a preaveraged Oseen fashion, the so-called Zimm model. We observe that the relaxation quantities mentioned above do not scale, in the presence or in the absence of the hydrodynamic interactions. Our results show that all the relaxation forms depend on the number of monomers in the networks in the absence of the hydrodynamic interactions (Rouse model), while by taking into account the hydrodynamic interactions the results do not vary too much.
Relaxation of polymers modeled by generalized Husimi cacti
Energy Technology Data Exchange (ETDEWEB)
Galiceanu, M, E-mail: mircea@fisica.ufpr.b [Departamento de Fisica, Universidade Federal do Parana, 81531-990 Curitiba (Brazil)
2010-07-30
We focus on the generalized Husimi cacti, which are dual structures to the dendrimers but, distinct from the latter, contain loops. We determine their complete spectra by making use of the normal mode analysis. These spectra have been used in computing some physical quantities, such as the averaged monomer displacement and the mechanical relaxation moduli with its two components: the storage and the loss modulus. We also study the dynamics of Husimi cacti in solutions, introducing the hydrodynamic interactions in a preaveraged Oseen fashion, the so-called Zimm model. We observe that the relaxation quantities mentioned above do not scale, in the presence or in the absence of the hydrodynamic interactions. Our results show that all the relaxation forms depend on the number of monomers in the networks in the absence of the hydrodynamic interactions (Rouse model), while by taking into account the hydrodynamic interactions the results do not vary too much.
Convex Relaxations for a Generalized Chan-Vese Model
Bae, Egil
2013-01-01
We revisit the Chan-Vese model of image segmentation with a focus on the encoding with several integer-valued labeling functions. We relate several representations with varying amount of complexity and demonstrate the connection to recent relaxations for product sets and to dual maxflow-based formulations. For some special cases, it can be shown that it is possible to guarantee binary minimizers. While this is not true in general, we show how to derive a convex approximation of the combinatorial problem for more than 4 phases. We also provide a method to avoid overcounting of boundaries in the original Chan-Vese model without departing from the efficient product-set representation. Finally, we derive an algorithm to solve the associated discretized problem, and demonstrate that it allows to obtain good approximations for the segmentation problem with various number of regions. © 2013 Springer-Verlag.
String networks in generalized May-Leonard models
Avelino, P P; Menezes, J; de Oliveira, B F
2013-01-01
Generalized May-Leonard models have proven to be a powerful tool in the study of the dynamics complex biological and ecological systems. In this letter we give specific examples of models leading to the formation of string networks. We show that, in order to promote coexistence, the species may arrange themselves around regions with a high number density of empty sites generated by predator-prey interactions between competing species. These configurations extend into the third dimension giving rise to string networks. We investigate the corresponding dynamics using both stochastic and mean field theory simulations, showing that the coarsening of these string networks follows a scaling law which is analogous to that found in other physical systems in condensed matter and cosmology.
Generalized Skyrme model with the loosely bound potential
Gudnason, Sven Bjarke; Ma, Nana
2016-01-01
We study a generalization of the loosely bound Skyrme model which consists of the Skyrme model with a sixth-order derivative term and the second-order loosely bound potential. We use the rational map approximation for the 4-Skyrmion and calculate the binding energy and estimate the systematic error in using the latter approximation. In the parameter space that we can explore within the rational map approximation, we find classical binding energies as low as 1.8% and once taking into account the contribution from spin-isospin quantization we obtain binding energies as low as 5.3%. We also calculate the contribution from the sixth-order derivative term to the electric charge density and axial coupling.
A stellar model with diffusion in general relativity
Alho, Artur
2016-01-01
We consider a spherically symmetric stellar model in general relativity whose interior consists of a pressureless fluid undergoing microscopic velocity diffusion in a cosmological scalar field. We show that the diffusion dynamics compel the interior to be spatially homogeneous, by which one can infer immediately that within our model, and in contrast to the diffusion-free case, no naked singularities can form in the gravitational collapse. We then study the problem of matching an exterior Bondi type metric to the surface of the star and find that the exterior can be chosen to be a modified Vaidya metric with variable cosmological constant. Finally, we study in detail the causal structure of an explicit, self-similar solution.
Optimisation of a parallel ocean general circulation model
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M. I. Beare
Full Text Available This paper presents the development of a general-purpose parallel ocean circulation model, for use on a wide range of computer platforms, from traditional scalar machines to workstation clusters and massively parallel processors. Parallelism is provided, as a modular option, via high-level message-passing routines, thus hiding the technical intricacies from the user. An initial implementation highlights that the parallel efficiency of the model is adversely affected by a number of factors, for which optimisations are discussed and implemented. The resulting ocean code is portable and, in particular, allows science to be achieved on local workstations that could otherwise only be undertaken on state-of-the-art supercomputers.
Directory of Open Access Journals (Sweden)
Sadettin Gungor
2008-04-01
Full Text Available Ministry of Health, Mother and Child Health and Family Planning General Directorate; Turkey Field Office of UNFPA, and Gulhane Military Medical Academy (GMMA of Turkish Armed Forces have been conducting a program to increase male concern and participation in sexual and reproductive health in a positive and supporting way. Specialist physicians and nurses from military hospitals were trained by Ministry of Health as trainers (October 2002- September 2003 by one-week courses on interactive training skills. Primary physicians, nurses and medical petty officers were trained as field trainers and counselors (March 2003-April 2004. Training rooms with standardized training material were established in all of the military garrisons. Soldiers were given the one-day participatory course. Trained medical staff also provided individual counseling and services. All training rooms were coded and connected to Reproductive Health Network established within the Intranet of Army. Reproductive Health activities were included in the regular supervision scheme of the army. Since April 2004 740.000 soldiers were given the one-day course. A total of 4000 military medical staff was educated as Trainers. A total of 580 training rooms were established. Twenty of Military Hospitals became a center of reproductive health training and service delivery. Since large-scale intervention is necessary to reach male population, the army seems to be the best possible venue in Turkey. [TAF Prev Med Bull. 2008; 7(2: 97-106
Directory of Open Access Journals (Sweden)
Anne Brigitte Albrectsen
2008-04-01
Full Text Available Ministry of Health, Mother and Child Health and Family Planning General Directorate; Turkey Field Office of UNFPA, and Gulhane Military Medical Academy (GMMA of Turkish Armed Forces have been conducting a program to increase male concern and participation in sexual and reproductive health in a positive and supporting way. Specialist physicians and nurses from military hospitals were trained by Ministry of Health as trainers (October 2002- September 2003 by one-week courses on interactive training skills. Primary physicians, nurses and medical petty officers were trained as field trainers and counselors (March 2003-April 2004. Training rooms with standardized training material were established in all of the military garrisons. Soldiers were given the one-day participatory course. Trained medical staff also provided individual counseling and services. All training rooms were coded and connected to Reproductive Health Network established within the Intranet of Army. Reproductive Health activities were included in the regular supervision scheme of the army. Since April 2004 740.000 soldiers were given the one-day course. A total of 4000 military medical staff was educated as Trainers. A total of 580 training rooms were established. Twenty of Military Hospitals became a center of reproductive health training and service delivery. Since large-scale intervention is necessary to reach male population, the army seems to be the best possible venue in Turkey. [TAF Prev Med Bull 2008; 7(2.000: 97-106
A Generalized Statistical Uncertainty Model for Satellite Precipitation Products
Sarachi, S.
2013-12-01
A mixture model of Generalized Normal Distribution and Gamma distribution (GND-G) is used to model the joint probability distribution of satellite-based and stage IV radar rainfall under a given spatial and temporal resolution (e.g. 1°x1° and daily rainfall). The distribution parameters of GND-G are extended across various rainfall rates and spatial and temporal resolutions. In the study, GND-G is used to describe the uncertainty of the estimates from Precipitation Estimation from Remote Sensing Information using Artificial Neural Network algorithm (PERSIANN). The stage IV-based multi-sensor precipitation estimates (MPE) are used as reference measurements .The study area for constructing the uncertainty model covers a 15°×15°box of 0.25°×0.25° cells over the eastern United States for summer 2004 to 2009. Cells are aggregated in space and time to obtain data with different resolutions for the construction of the model's parameter space. Result shows that comparing to the other statistical uncertainty models, GND-G fits better than the other models, such as Gaussian and Gamma distributions, to the reference precipitation data. The impact of precipitation uncertainty to the stream flow is further demonstrated by Monte Carlo simulation of precipitation forcing in the hydrologic model. The NWS DMIP2 basins over Illinois River basin south of Siloam is selected in this case study. The data covers the time period of 2006 to 2008.The uncertainty range of stream flow from precipitation of GND-G distributions calculated and will be discussed.
On the General Class of Models of Adiabatic Evolution
Sun, Jie; Lu, Songfeng; Liu, Fang
2016-10-01
The general class of models of adiabatic evolution was proposed to speed up the usual adiabatic computation in the case of quantum search problem. It was shown [8] that, by temporarily increasing the ground state energy of a time-dependent Hamiltonian to a suitable quantity, the quantum computation can perform the calculation in time complexity O(1). But it is also known that if the overlap between the initial and final states of the system is zero, then the computation based on the generalized models of adiabatic evolution can break down completely. In this paper, we find another severe limitation for this class of adiabatic evolution-based algorithms, which should be taken into account in applications. That is, it is still possible that this kind of evolution designed to deal with the quantum search problem fails completely if the interpolating paths in the system Hamiltonian are chosen inappropriately, while the usual adiabatic evolutions can do the same job relatively effectively. This implies that it is not always recommendable to use nonlinear paths in adiabatic computation. On the contrary, the usual simple adiabatic evolution may be sufficient for effective use.
A modified EM algorithm for estimation in generalized mixed models.
Steele, B M
1996-12-01
Application of the EM algorithm for estimation in the generalized mixed model has been largely unsuccessful because the E-step cannot be determined in most instances. The E-step computes the conditional expectation of the complete data log-likelihood and when the random effect distribution is normal, this expectation remains an intractable integral. The problem can be approached by numerical or analytic approximations; however, the computational burden imposed by numerical integration methods and the absence of an accurate analytic approximation have limited the use of the EM algorithm. In this paper, Laplace's method is adapted for analytic approximation within the E-step. The proposed algorithm is computationally straightforward and retains much of the conceptual simplicity of the conventional EM algorithm, although the usual convergence properties are not guaranteed. The proposed algorithm accommodates multiple random factors and random effect distributions besides the normal, e.g., the log-gamma distribution. Parameter estimates obtained for several data sets and through simulation show that this modified EM algorithm compares favorably with other generalized mixed model methods.
General analysis of dark radiation in sequestered string models
Energy Technology Data Exchange (ETDEWEB)
Cicoli, Michele [ICTP,Strada Costiera 11, Trieste 34014 (Italy); Dipartimento di Fisica e Astronomia, Università di Bologna,via Irnerio 46, 40126 Bologna (Italy); INFN, Sezione di Bologna,via Irnerio 46, 40126 Bologna (Italy); Muia, Francesco [Dipartimento di Fisica e Astronomia, Università di Bologna,via Irnerio 46, 40126 Bologna (Italy); INFN, Sezione di Bologna,via Irnerio 46, 40126 Bologna (Italy)
2015-12-22
We perform a general analysis of axionic dark radiation produced from the decay of the lightest modulus in the sequestered LARGE Volume Scenario. We discuss several cases depending on the form of the Kähler metric for visible sector matter fields and the mechanism responsible for achieving a de Sitter vacuum. The leading decay channels which determine dark radiation predictions are to hidden sector axions, visible sector Higgses and SUSY scalars depending on their mass. We show that in most of the parameter space of split SUSY-like models squarks and sleptons are heavier than the lightest modulus. Hence dark radiation predictions previously obtained for MSSM-like cases hold more generally also for split SUSY-like cases since the decay channel to SUSY scalars is kinematically forbidden. However the inclusion of string loop corrections to the Kähler potential gives rise to a parameter space region where the decay channel to SUSY scalars opens up, leading to a significant reduction of dark radiation production. In this case, the simplest model with a shift-symmetric Higgs sector can suppress the excess of dark radiation ΔN{sub eff} to values as small as 0.14, in perfect agreement with current experimental bounds. Depending on the exact mass of the SUSY scalars all values in the range 0.14≲ΔN{sub eff}≲1.6 are allowed. Interestingly dark radiation overproduction can be avoided also in the absence of a Giudice-Masiero coupling.
The truthful signalling hypothesis: an explicit general equilibrium model.
Hausken, Kjell; Hirshleifer, Jack
2004-06-21
In mating competition, the truthful signalling hypothesis (TSH), sometimes known as the handicap principle, asserts that higher-quality males signal while lower-quality males do not (or else emit smaller signals). Also, the signals are "believed", that is, females mate preferentially with higher-signalling males. Our analysis employs specific functional forms to generate analytic solutions and numerical simulations that illuminate the conditions needed to validate the TSH. Analytic innovations include: (1) A Mating Success Function indicates how female mating choices respond to higher and lower signalling levels. (2) A congestion function rules out corner solutions in which females would mate exclusively with higher-quality males. (3) A Malthusian condition determines equilibrium population size as related to per-capita resource availability. Equilibria validating the TSH are achieved over a wide range of parameters, though not universally. For TSH equilibria it is not strictly necessary that the high-quality males have an advantage in terms of lower per-unit signalling costs, but a cost difference in favor of the low-quality males cannot be too great if a TSH equilibrium is to persist. And although the literature has paid less attention to these points, TSH equilibria may also fail if: the quality disparity among males is too great, or the proportion of high-quality males in the population is too large, or if the congestion effect is too weak. Signalling being unprofitable in aggregate, it can take off from a no-signalling equilibrium only if the trait used for signalling is not initially a handicap, but instead is functionally useful at low levels. Selection for this trait sets in motion a bandwagon, whereby the initially useful indicator is pushed by male-male competition into the domain where it does indeed become a handicap.
Directory of Open Access Journals (Sweden)
Moses Stephen
2007-03-01
Full Text Available Abstract Background Recent clinical trials in Africa, in combination with several observational epidemiological studies, have provided evidence that male circumcision can reduce HIV female-to-male transmission risk by 60% or more. However, the public health impact of large-scale male circumcision programs for HIV prevention is unclear. Methods Two mathematical models were examined to explore this issue: a random mixing model and a compartmental model that distinguishes risk groups associated with sex work. In the compartmental model, two scenarios were developed, one calculating HIV transmission and prevalence in a context similar to the country of Botswana, and one similar to Nyanza Province, in western Kenya. Results In both models, male circumcision programs resulted in large and sustained declines in HIV prevalence over time among both men and women. Men benefited somewhat more than women, but prevalence among women was also reduced substantially. With 80% male circumcision uptake, the reductions in prevalence ranged from 45% to 67% in the two "countries", and with 50% uptake, from 25% to 41%. It would take over a decade for the intervention to reach its full effect. Conclusion Large-scale uptake of male circumcision services in African countries with high HIV prevalence, and where male circumcision is not now routinely practised, could lead to substantial reductions in HIV transmission and prevalence over time among both men and women.
Vickram, A S; Kamini, A Rao; Das, Raja; Pathy, M Ramesh; Parameswari, R; Archana, K; Sridharan, T B
2016-08-01
Seminal fluid is the secretion from many glands comprised of several organic and inorganic compounds including free amino acids, proteins, fructose, glucosidase, zinc, and other scavenging elements like Mg(2+), Ca(2+), K(+), and Na(+). Therefore, in the view of development of novel approaches and proper diagnosis to male infertility, overall understanding of the biochemical and molecular composition and its role in regulation of sperm quality is highly desirable. Perhaps this can be achieved through artificial intelligence. This study was aimed to elucidate and predict various biochemical markers present in human seminal plasma with three different neural network models. A total of 177 semen samples were collected for this research (both fertile and infertile samples) and immediately processed to prepare a semen analysis report, based on the protocol of the World Health Organization (WHO [2010]). The semen samples were then categorized into oligoasthenospermia (n=35), asthenospermia (n=35), azoospermia (n=22), normospermia (n=34), oligospermia (n=34), and control (n=17). The major biochemical parameters like total protein content, fructose, glucosidase, and zinc content were elucidated by standard protocols. All the biochemical markers were predicted by using three different artificial neural network (ANN) models with semen parameters as inputs. Of the three models, the back propagation neural network model (BPNN) yielded the best results with mean absolute error 0.025, -0.080, 0.166, and -0.057 for protein, fructose, glucosidase, and zinc, respectively. This suggests that BPNN can be used to predict biochemical parameters for the proper diagnosis of male infertility in assisted reproductive technology (ART) centres. AAS: absorption spectroscopy; AI: artificial intelligence; ANN: artificial neural networks; ART: assisted reproductive technology; BPNN: back propagation neural network model; DT: decision tress; MLP: multilayer perceptron; PESA: percutaneous
Observational constraints on new generalized Chaplygin gas model
Liao, Kai; Zhu, Zong-Hong
2012-01-01
We use the latest data to investigate observational constraints on the new generalized Chaplygin gas (NGCG) model. Using the Markov Chain Monte Carlo (MCMC) method, we constrain the NGCG model with the type Ia supernovae (SNe Ia) from Union2 set (557 data), the usual baryonic acoustic oscillation (BAO) observation from the spectroscopic Sloan Digital Sky Survey (SDSS) data release 7 (DR7) galaxy sample, the cosmic microwave background (CMB) observation from the 7-year Wilkinson Microwave Anisotropy Probe (WMAP7) results, the newly revised $H(z)$ data, as well as a value of $\\theta_{BAO} (z=0.55) = (3.90 \\pm 0.38)^{\\circ}$ for the angular BAO scale. The constraint results for NGCG model are $\\omega_X = -1.0510_{-0.1685}^{+0.1563}(1\\sigma)_{-0.2398}^{+0.2226}(2\\sigma)$, $\\eta = 1.0117_{-0.0502}^{+0.0469}(1\\sigma)_{-0.0716}^{+0.0693}(2\\sigma)$, and $\\Omega_X = 0.7297_{-0.0276}^{+0.0229}(1\\sigma)_{-0.0402}^{+0.0329}(2\\sigma)$, which give a rather stringent constraint. From the results, we can see a phantom model ...
Observational constraints on the new generalized Chaplygin gas model
Institute of Scientific and Technical Information of China (English)
Kai Liao; Yu Pan; Zong-Hong Zhu
2013-01-01
We use the latest data to investigate observational constraints on the new generalized Chaplygin gas (NGCG) model.Using the Markov Chain Monte Carlo method,we constrain the NGCG model with type Ⅰa supernovae from the Union2 set (557 data),the usual baryonic acoustic oscillation (BAO) observation from the spectroscopic Sloan Digital Sky Survey data release 7 galaxy sample,the cosmic microwave background observation from the 7-year Wilkinson Microwave Anisotropy Probe results,newly revised data on H(z),as well as a value of θBAO (z =0.55) =(3.90° ± 0.38°) for the angular BAO scale.The constraint results for the NGCG model are ωx=-1.0510(-0.1685)(+0.1563)(1σ)(-0.2398)(+0.2226)(2σ),η=1.0117(-0.0502)(+0.0469)(1σ)(-0.0716)(+0.0693)(2σ) and Ωx=0.7297(-0.0276)(+0.0229)(1σ)(-0.0402)(+0.0329)(2σ),which give a rather stringent constraint.From the results,we can see that a phantom model is slightly favored and the proba-bility that energy transfers from dark matter to dark energy is a little larger than the inverse.
Generalized Poisson-Lindely Distribution in Promotion Time Cure Model
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Ahmad Reza Baghestani
2014-12-01
Full Text Available 1024x768 Long-term survival analysis has been improved in the last decade and most of the models concentrate on the promotion time cure model that proposed by Chen (1999. These models are based on the distribution of latent variable N, number of initiated node cells. In this paper we proposed a Generalized Poisson-Lindely distribution that is another option instead of Negative Binomial distribution when there is overdispersion. The results indicated a better fitness compared to others, because of its more flexibility. Parameter estimation has been done by Bayesian approach, in a real data set and a simulation study has shown the advantages of proposed model. Normal 0 false false false /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}
Modeling Answer Change Behavior: An Application of a Generalized Item Response Tree Model
Jeon, Minjeong; De Boeck, Paul; van der Linden, Wim
2017-01-01
We present a novel application of a generalized item response tree model to investigate test takers' answer change behavior. The model allows us to simultaneously model the observed patterns of the initial and final responses after an answer change as a function of a set of latent traits and item parameters. The proposed application is illustrated…
Directory of Open Access Journals (Sweden)
Abhay Sharma
Full Text Available Available instances of inheritance of epigenetic transgenerational phenotype are limited to environmental exposures during embryonic and adult gonadal development. Adult exposures can also affect gametogenesis and thereby potentially result in reprogramming of the germline. Although examples of epigenetic effects on gametogenesis exist, it is notable that transgenerational inheritance of environment-induced adult phenotype has not yet been reported. Epigenetic codes are considered to be critical in neural plasticity. A Drosophila systems model of pentylenetetrazole (PTZ induced long-term brain plasticity has recently been described. In this model, chronic PTZ treatment of adult males causes alterations in CNS transcriptome. Here, we describe our search for transgenerational spermatogenic inheritance of PTZ induced gene expression phenotype acquired by adult Drosophila males. We generated CNS transcriptomic profiles of F(1 adults after treating F(0 adult males with PTZ and of F(2 adults resulting from a cross between F(1 males and normal females. Surprisingly, microarray clustering showed F(1 male profile as closest to F(1 female and F(0 male profile closest to F(2 male. Differentially expressed genes in F(1 males, F(1 females and F(2 males showed significant overlap with those caused by PTZ. Interestingly, microarray evidence also led to the identification of upregulated rRNA in F(2 males. Next, we generated microarray expression profiles of adult testis from F(0 and F(1 males. Further surprising, clustering of CNS and testis profiles and matching of differentially expressed genes in them provided evidence of a spermatogenic mechanism in the transgenerational effect observed. To our knowledge, we report for the first time detection of transgenerational spermatogenic inheritance of adult acquired somatic gene expression characteristic. The Drosophila systems model offers an excellent opportunity to understand the epigenetic mechanisms underlying
Solitons and kinks in a general car-following model
Kurtze, Douglas A.
2013-09-01
We study a general car-following model of traffic flow on an infinitely long single-lane road, which assumes that a car's acceleration depends on time-delayed values of its own speed, the headway between it and the car ahead, and the rate of change of headway, but makes minimal assumptions about the functional form of that dependence. We present a detailed characterization of the onset of linear instability; in particular we find a specific limit on the delay time below which the marginal wave number at the onset of instability is zero, and another specific limit on the delay time above which steady flow is always unstable. Crucially, the threshold of absolute stability generally does not coincide with an inflection point of the steady-state velocity function. When the marginal perturbation at onset has wave number 0, we show that Burgers and Korteweg-de Vries (KdV) equations can be derived under the usual assumptions, and that corrections to the KdV equation “select” a single member of the one-parameter set of its one-soliton solutions by driving a slow evolution of the soliton parameter. While in previous models this selected soliton has always marked the threshold of a finite-amplitude instability of linearly stable steady flow, we find that it can alternatively be a stable, small-amplitude jam that occurs when steady flow is linearly unstable. The model reduces to the usual modified Korteweg-de Vries (mKdV) equation only in the special situation that the threshold of absolute stability coincides with an inflection point of the steady-state velocity function; in general, near the threshold of absolute stability the model reduces instead to a KdV equation in the regime of small solitons, while near an inflection point it reduces to a Hayakawa-Nakanishi equation. Like the mKdV equation, the Hayakawa-Nakanishi equation admits a continuous family of kink solutions, and the selection criterion arising from the corrections to this equation can be written down
Adaptive Error Estimation in Linearized Ocean General Circulation Models
Chechelnitsky, Michael Y.
1999-01-01
Data assimilation methods are routinely used in oceanography. The statistics of the model and measurement errors need to be specified a priori. This study addresses the problem of estimating model and measurement error statistics from observations. We start by testing innovation based methods of adaptive error estimation with low-dimensional models in the North Pacific (5-60 deg N, 132-252 deg E) to TOPEX/POSEIDON (TIP) sea level anomaly data, acoustic tomography data from the ATOC project, and the MIT General Circulation Model (GCM). A reduced state linear model that describes large scale internal (baroclinic) error dynamics is used. The methods are shown to be sensitive to the initial guess for the error statistics and the type of observations. A new off-line approach is developed, the covariance matching approach (CMA), where covariance matrices of model-data residuals are "matched" to their theoretical expectations using familiar least squares methods. This method uses observations directly instead of the innovations sequence and is shown to be related to the MT method and the method of Fu et al. (1993). Twin experiments using the same linearized MIT GCM suggest that altimetric data are ill-suited to the estimation of internal GCM errors, but that such estimates can in theory be obtained using acoustic data. The CMA is then applied to T/P sea level anomaly data and a linearization of a global GFDL GCM which uses two vertical modes. We show that the CMA method can be used with a global model and a global data set, and that the estimates of the error statistics are robust. We show that the fraction of the GCM-T/P residual variance explained by the model error is larger than that derived in Fukumori et al.(1999) with the method of Fu et al.(1993). Most of the model error is explained by the barotropic mode. However, we find that impact of the change in the error statistics on the data assimilation estimates is very small. This is explained by the large
Generalized PSF modeling for optimized quantitation in PET imaging
Ashrafinia, Saeed; Mohy-ud-Din, Hassan; Karakatsanis, Nicolas A.; Jha, Abhinav K.; Casey, Michael E.; Kadrmas, Dan J.; Rahmim, Arman
2017-06-01
modeling does not offer optimized PET quantitation, and that PSF overestimation may provide enhanced SUV quantitation. Furthermore, generalized PSF modeling may provide a valuable approach for quantitative tasks such as treatment-response assessment and prognostication.
Levant, Ronald F; Hall, Rosalie J; Weigold, Ingrid K; McCurdy, Eric R
2016-10-01
The construct validity of the Male Role Norms Inventory-Short Form (MRNI-SF) was assessed using a latent variable approach implemented with structural equation modeling (SEM). The MRNI-SF was specified as having a bifactor structure, and validation scales were also specified as latent variables. The latent variable approach had the advantages of separating effects of general and specific factors and controlling for some sources of measurement error. Data (N = 484) were from a diverse sample (38.8% men of color, 22.3% men of diverse sexualities) of community-dwelling and college men who responded to an online survey. The construct validity of the MRNI-SF General Traditional Masculinity Ideology factor was supported for all 4 of the proposed latent correlations with: (a) Male Role Attitudes Scale; (b) general factor of Conformity to Masculine Norms Inventory-46; (c) higher-order factor of Gender Role Conflict Scale; and (d) Personal Attributes Questionnaire-Masculinity Scale. Significant correlations with relevant other latent factors provided concurrent validity evidence for the MRNI-SF specific factors of Negativity toward Sexual Minorities, Importance of Sex, Restrictive Emotionality, and Toughness, with all 8 of the hypothesized relationships supported. However, 3 relationships concerning Dominance were not supported. (The construct validity of the remaining 2 MRNI-SF specific factors-Avoidance of Femininity and Self-Reliance through Mechanical Skills was not assessed.) Comparisons were made, and meaningful differences noted, between the latent correlations emphasized in this study and their raw variable counterparts. Results are discussed in terms of the advantages of an SEM approach and the unique characteristics of the bifactor model. (PsycINFO Database Record
Local Signaling Environments and Human Male Infertility: What Can Be Learned from Mouse Models
Nalam, Roopa L.; Matzuk, Martin M.
2011-01-01
Infertility is one of the most prevalent public health problems facing young adult males in today’s society. A clear, treatable cause of infertility cannot be determined in a large number of these patients, and a growing body of evidence suggests that infertility in many of these men may be due to genetic causes. Studies utilizing animal models, and most importantly, mouse knockout technology, have been integral not only for the study of normal spermatogenesis but also for identifying proteins essential for this process, which in turn are candidate genes for causing human male infertility. Successful spermatogenesis depends on a delicate balance of local signaling factors, and this review focuses specifically on the genes that encode these factors. Normal functioning of all testicular cell types is not only essential for normal fertility but, as recently hypothesized, may also be crucial to prevent germ cell oncogenesis. Analysis of these processes using mouse models in vivo has provided investigators with an invaluable tool to effectively translate basic science research to the research of human disease and infertility. PMID:20456819
General Description of Fission Observables: GEF Model Code
Energy Technology Data Exchange (ETDEWEB)
Schmidt, K.-H. [CENBG, CNRS/IN2 P3, Chemin du Solarium, B.P. 120, F-33175 Gradignan (France); Jurado, B., E-mail: jurado@cenbg.in2p3.fr [CENBG, CNRS/IN2 P3, Chemin du Solarium, B.P. 120, F-33175 Gradignan (France); Amouroux, C. [CEA, DSM-Saclay (France); Schmitt, C., E-mail: schmitt@ganil.fr [GANIL, Bd. Henri Becquerel, B.P. 55027, F-14076 Caen Cedex 05 (France)
2016-01-15
The GEF (“GEneral description of Fission observables”) model code is documented. It describes the observables for spontaneous fission, neutron-induced fission and, more generally, for fission of a compound nucleus from any other entrance channel, with given excitation energy and angular momentum. The GEF model is applicable for a wide range of isotopes from Z = 80 to Z = 112 and beyond, up to excitation energies of about 100 MeV. The results of the GEF model are compared with fission barriers, fission probabilities, fission-fragment mass- and nuclide distributions, isomeric ratios, total kinetic energies, and prompt-neutron and prompt-gamma yields and energy spectra from neutron-induced and spontaneous fission. Derived properties of delayed neutrons and decay heat are also considered. The GEF model is based on a general approach to nuclear fission that explains a great part of the complex appearance of fission observables on the basis of fundamental laws of physics and general properties of microscopic systems and mathematical objects. The topographic theorem is used to estimate the fission-barrier heights from theoretical macroscopic saddle-point and ground-state masses and experimental ground-state masses. Motivated by the theoretically predicted early localisation of nucleonic wave functions in a necked-in shape, the properties of the relevant fragment shells are extracted. These are used to determine the depths and the widths of the fission valleys corresponding to the different fission channels and to describe the fission-fragment distributions and deformations at scission by a statistical approach. A modified composite nuclear-level-density formula is proposed. It respects some features in the superfluid regime that are in accordance with new experimental findings and with theoretical expectations. These are a constant-temperature behaviour that is consistent with a considerably increased heat capacity and an increased pairing condensation energy that is
Modeling of space environment impact on nanostructured materials. General principles
Voronina, Ekaterina; Novikov, Lev
2016-07-01
In accordance with the resolution of ISO TC20/SC14 WG4/WG6 joint meeting, Technical Specification (TS) 'Modeling of space environment impact on nanostructured materials. General principles' which describes computer simulation methods of space environment impact on nanostructured materials is being prepared. Nanomaterials surpass traditional materials for space applications in many aspects due to their unique properties associated with nanoscale size of their constituents. This superiority in mechanical, thermal, electrical and optical properties will evidently inspire a wide range of applications in the next generation spacecraft intended for the long-term (~15-20 years) operation in near-Earth orbits and the automatic and manned interplanetary missions. Currently, ISO activity on developing standards concerning different issues of nanomaterials manufacturing and applications is high enough. Most such standards are related to production and characterization of nanostructures, however there is no ISO documents concerning nanomaterials behavior in different environmental conditions, including the space environment. The given TS deals with the peculiarities of the space environment impact on nanostructured materials (i.e. materials with structured objects which size in at least one dimension lies within 1-100 nm). The basic purpose of the document is the general description of the methodology of applying computer simulation methods which relate to different space and time scale to modeling processes occurring in nanostructured materials under the space environment impact. This document will emphasize the necessity of applying multiscale simulation approach and present the recommendations for the choice of the most appropriate methods (or a group of methods) for computer modeling of various processes that can occur in nanostructured materials under the influence of different space environment components. In addition, TS includes the description of possible
The DSM-5 dimensional trait model and five-factor models of general personality.
Gore, Whitney L; Widiger, Thomas A
2013-08-01
The current study tests empirically the relationship of the dimensional trait model proposed for the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) with five-factor models of general personality. The DSM-5 maladaptive trait dimensional model proposal included 25 traits organized within five broad domains (i.e., negative affectivity, detachment, antagonism, disinhibition, and psychoticism). Consistent with the authors of the proposal, it was predicted that negative affectivity would align with five-factor model (FFM) neuroticism, detachment with FFM introversion, antagonism with FFM antagonism, disinhibition with low FFM conscientiousness and, contrary to the proposal; psychoticism would align with FFM openness. Three measures of alternative five-factor models of general personality were administered to 445 undergraduates along with the Personality Inventory for DSM-5. The results provided support for the hypothesis that all five domains of the DSM-5 dimensional trait model are maladaptive variants of general personality structure, including the domain of psychoticism.
A model of destination-language acquisition: application to male immigrants in Canada.
Chiswick, B R; Miller, P W
2001-08-01
We develop a model using human capital theory and an immigrant adjustment process to generate hypotheses on the acquisition of destination-language skills among immigrants. The model is tested for adult male immigrants in the 1991 Census of Canada. Use of English or French is greater, the younger the age at migration, the longer the duration of residence, the higher the educational attainment, the farther the country of origin from Canada, and the linguistically closer the mother tongue to English or French, and among those who are not refugees, those from a former British, French, or American colony, and those who live in an area where fewer people speak the respondent's mother tongue. The explanatory variables based on birthplace have behavioral interpretations and possess almost as much explanatory power as the birthplace dummy variables.
Generalized multiplicative error models: Asymptotic inference and empirical analysis
Li, Qian
This dissertation consists of two parts. The first part focuses on extended Multiplicative Error Models (MEM) that include two extreme cases for nonnegative series. These extreme cases are common phenomena in high-frequency financial time series. The Location MEM(p,q) model incorporates a location parameter so that the series are required to have positive lower bounds. The estimator for the location parameter turns out to be the minimum of all the observations and is shown to be consistent. The second case captures the nontrivial fraction of zero outcomes feature in a series and combines a so-called Zero-Augmented general F distribution with linear MEM(p,q). Under certain strict stationary and moment conditions, we establish a consistency and asymptotic normality of the semiparametric estimation for these two new models. The second part of this dissertation examines the differences and similarities between trades in the home market and trades in the foreign market of cross-listed stocks. We exploit the multiplicative framework to model trading duration, volume per trade and price volatility for Canadian shares that are cross-listed in the New York Stock Exchange (NYSE) and the Toronto Stock Exchange (TSX). We explore the clustering effect, interaction between trading variables, and the time needed for price equilibrium after a perturbation for each market. The clustering effect is studied through the use of univariate MEM(1,1) on each variable, while the interactions among duration, volume and price volatility are captured by a multivariate system of MEM(p,q). After estimating these models by a standard QMLE procedure, we exploit the Impulse Response function to compute the calendar time for a perturbation in these variables to be absorbed into price variance, and use common statistical tests to identify the difference between the two markets in each aspect. These differences are of considerable interest to traders, stock exchanges and policy makers.
Toward a general psychological model of tension and suspense
Directory of Open Access Journals (Sweden)
Moritz eLehne
2015-02-01
Full Text Available Tension and suspense are powerful emotional experiences that occur in a wide variety of contexts (e.g., in music, film, literature, and everyday life. The omnipresence of tension experiences suggests that they build on very basic cognitive and affective mechanisms. However, the psychological underpinnings of tension experiences remain largely unexplained, and tension and suspense are rarely discussed from a general, domain-independent perspective. In this paper, we argue that tension experiences in different contexts (e.g., musical tension or suspense in a movie build on the same underlying psychological processes. We discuss key components of tension experiences and propose a domain-independent model of tension and suspense. According to this model, tension experiences originate from states of conflict, instability, dissonance, or uncertainty that trigger predictive processes directed at future events of emotional significance. We also discuss possible neural mechanisms underlying experiences of tension. The model provides a theoretical framework that can inform future empirical research on tension phenomena.
A generalized model for estimating the energy density of invertebrates
James, Daniel A.; Csargo, Isak J.; Von Eschen, Aaron; Thul, Megan D.; Baker, James M.; Hayer, Cari-Ann; Howell, Jessica; Krause, Jacob; Letvin, Alex; Chipps, Steven R.
2012-01-01
Invertebrate energy density (ED) values are traditionally measured using bomb calorimetry. However, many researchers rely on a few published literature sources to obtain ED values because of time and sampling constraints on measuring ED with bomb calorimetry. Literature values often do not account for spatial or temporal variability associated with invertebrate ED. Thus, these values can be unreliable for use in models and other ecological applications. We evaluated the generality of the relationship between invertebrate ED and proportion of dry-to-wet mass (pDM). We then developed and tested a regression model to predict ED from pDM based on a taxonomically, spatially, and temporally diverse sample of invertebrates representing 28 orders in aquatic (freshwater, estuarine, and marine) and terrestrial (temperate and arid) habitats from 4 continents and 2 oceans. Samples included invertebrates collected in all seasons over the last 19 y. Evaluation of these data revealed a significant relationship between ED and pDM (r2 = 0.96, p calorimetry approaches. This model should prove useful for a wide range of ecological studies because it is unaffected by taxonomic, seasonal, or spatial variability.
A Pacific Ocean general circulation model for satellite data assimilation
Chao, Y.; Halpern, D.; Mechoso, C. R.
1991-01-01
A tropical Pacific Ocean General Circulation Model (OGCM) to be used in satellite data assimilation studies is described. The transfer of the OGCM from a CYBER-205 at NOAA's Geophysical Fluid Dynamics Laboratory to a CRAY-2 at NASA's Ames Research Center is documented. Two 3-year model integrations from identical initial conditions but performed on those two computers are compared. The model simulations are very similar to each other, as expected, but the simulations performed with the higher-precision CRAY-2 is smoother than that with the lower-precision CYBER-205. The CYBER-205 and CRAY-2 use 32 and 64-bit mantissa arithmetic, respectively. The major features of the oceanic circulation in the tropical Pacific, namely the North Equatorial Current, the North Equatorial Countercurrent, the South Equatorial Current, and the Equatorial Undercurrent, are realistically produced and their seasonal cycles are described. The OGCM provides a powerful tool for study of tropical oceans and for the assimilation of satellite altimetry data.
Generalized Hidden Markov Models To Handwritten Devanagari Word Recognition
Directory of Open Access Journals (Sweden)
Mr. Pradeep Singh Thakur
2012-06-01
Full Text Available Hidden Markov Models (HMM have long been a popular choice for Western cursive handwriting recognition following their success in speech recognition. Even for the recognition of Oriental scripts such as Chinese, Japanese and Korean, Hidden Markov Models are increasingly being used to model substrokes of characters. However, when it comes to Indic script recognition, the published work employing HMMs is limited, and generally focused on isolated character recognition. In this effort, a data-driven HMM-based handwritten word recognition system for Hindi, an Indic script, is proposed. Though Devanagari is the script for Hindi, which is the official language of India, its character and word recognition pose great challenges due to large variety of symbols and their proximity in appearance. The accuracies obtained ranged from 30�0to 60�0with lexicon. These initial results are promising and warrant further research in this direction. The results are also encouraging to explore possibilities for adopting the approach to other Indic scripts as well.
A general route diversity model for convergent terrestrial microwave links
Paulson, Kevin S.; Usman, Isa S.; Watson, Robert J.
2006-06-01
This research examines route diversity as a fade mitigation technique in the presence of rain for convergent, terrestrial, microwave links. A general model is derived which predicts the joint distribution of rain attenuation on arbitrary pairs of convergent microwave links, directly from the link parameters. It is assumed that pairs of links have joint rain attenuation distributions that are bilognormally distributed. Four of the five distribution parameters can be estimated from International Telecommunication Union recommendation models. A maximum likelihood estimation method was used in a previous paper to estimate the fifth parameter, that is, the covariance or correlation. In this paper an empirical model is reported, linking the correlation of log rain fade with the geometry and radio parameters of the pair of links. From these distributions, the advantage due to route diversity may be calculated for arbitrary fade margins. Furthermore, the predicted diversity statistics vary smoothly and yield plausible extrapolations into low-probability scenarios. Diversity improvement is calculated for a set of example link scenarios.
Bayesian inference for generalized linear models for spiking neurons
Directory of Open Access Journals (Sweden)
Sebastian Gerwinn
2010-05-01
Full Text Available Generalized Linear Models (GLMs are commonly used statistical methods for modelling the relationship between neural population activity and presented stimuli. When the dimension of the parameter space is large, strong regularization has to be used in order to fit GLMs to datasets of realistic size without overfitting. By imposing properly chosen priors over parameters, Bayesian inference provides an effective and principled approach for achieving regularization. Here we show how the posterior distribution over model parameters of GLMs can be approximated by a Gaussian using the Expectation Propagation algorithm. In this way, we obtain an estimate of the posterior mean and posterior covariance, allowing us to calculate Bayesian confidence intervals that characterize the uncertainty about the optimal solution. From the posterior we also obtain a different point estimate, namely the posterior mean as opposed to the commonly used maximum a posteriori estimate. We systematically compare the different inference techniques on simulated as well as on multi-electrode recordings of retinal ganglion cells, and explore the effects of the chosen prior and the performance measure used. We find that good performance can be achieved by choosing an Laplace prior together with the posterior mean estimate.
Generalized Fiducial Inference for Binary Logistic Item Response Models.
Liu, Yang; Hannig, Jan
2016-06-01
Generalized fiducial inference (GFI) has been proposed as an alternative to likelihood-based and Bayesian inference in mainstream statistics. Confidence intervals (CIs) can be constructed from a fiducial distribution on the parameter space in a fashion similar to those used with a Bayesian posterior distribution. However, no prior distribution needs to be specified, which renders GFI more suitable when no a priori information about model parameters is available. In the current paper, we apply GFI to a family of binary logistic item response theory models, which includes the two-parameter logistic (2PL), bifactor and exploratory item factor models as special cases. Asymptotic properties of the resulting fiducial distribution are discussed. Random draws from the fiducial distribution can be obtained by the proposed Markov chain Monte Carlo sampling algorithm. We investigate the finite-sample performance of our fiducial percentile CI and two commonly used Wald-type CIs associated with maximum likelihood (ML) estimation via Monte Carlo simulation. The use of GFI in high-dimensional exploratory item factor analysis was illustrated by the analysis of a set of the Eysenck Personality Questionnaire data.
The QOL-DASS Model to Estimate Overall Quality of Life and General Health
Directory of Open Access Journals (Sweden)
Mehrdad Mazaheri
2011-01-01
Full Text Available "n Objective: In order to find how rating the WHOQOL-BREF and DASS scales are combined to produce an overall measure of quality of life and satisfaction with health rating, a QOL-DASS model was designed ; and the strength of this hypothesized model was examined using the structural equation modeling "n "nMethod: Participants included a sample of 103 voluntary males who were divided into two groups of unhealthy (N=55 and healthy (N=48. To assess satisfaction and negative emotions of depression, anxiety and stress among the participants, they were asked to fill out the WHOQOLBREF and The Depression Anxiety Stress Scale (DASS-42. "nResults: Our findings on running the hypothesized model of QOL-DASS indicated that the proposed model of QOL-DASS fitted the data well for the both healthy and unhealthy groups "nConclusion: Our findings with CFA to evaluate the hypothesized model of QOL-DASS indicated that the different satisfaction domain ratings and the negative emotions of depression, anxiety and stress as the observed variables can represent the underlying constructs of general health and quality of life on both healthy and unhealthy groups.
Faraway, Julian J
2005-01-01
Linear models are central to the practice of statistics and form the foundation of a vast range of statistical methodologies. Julian J. Faraway''s critically acclaimed Linear Models with R examined regression and analysis of variance, demonstrated the different methods available, and showed in which situations each one applies. Following in those footsteps, Extending the Linear Model with R surveys the techniques that grow from the regression model, presenting three extensions to that framework: generalized linear models (GLMs), mixed effect models, and nonparametric regression models. The author''s treatment is thoroughly modern and covers topics that include GLM diagnostics, generalized linear mixed models, trees, and even the use of neural networks in statistics. To demonstrate the interplay of theory and practice, throughout the book the author weaves the use of the R software environment to analyze the data of real examples, providing all of the R commands necessary to reproduce the analyses. All of the ...
Convex foundations for generalized MaxEnt models
Frongillo, Rafael; Reid, Mark D.
2014-12-01
We present an approach to maximum entropy models that highlights the convex geometry and duality of generalized exponential families (GEFs) and their connection to Bregman divergences. Using our framework, we are able to resolve a puzzling aspect of the bijection of Banerjee and coauthors between classical exponential families and what they call regular Bregman divergences. Their regularity condition rules out all but Bregman divergences generated from log-convex generators. We recover their bijection and show that a much broader class of divergences correspond to GEFs via two key observations: 1) Like classical exponential families, GEFs have a "cumulant" C whose subdifferential contains the mean: Eo˜pθ[φ(o)]∈∂C(θ) ; 2) Generalized relative entropy is a C-Bregman divergence between parameters: DF(pθ,pθ')= D C(θ,θ') , where DF becomes the KL divergence for F = -H. We also show that every incomplete market with cost function C can be expressed as a complete market, where the prices are constrained to be a GEF with cumulant C. This provides an entirely new interpretation of prediction markets, relating their design back to the principle of maximum entropy.
General Analysis of Dark Radiation in Sequestered String Models
Cicoli, Michele
2015-01-01
We perform a general analysis of axionic dark radiation produced from the decay of the lightest modulus in the sequestered LARGE Volume Scenario. We discuss several cases depending on the form of the Kahler metric for visible sector matter fields and the mechanism responsible for achieving a de Sitter vacuum. The leading decay channels which determine dark radiation predictions are to hidden sector axions, visible sector Higgses and SUSY scalars depending on their mass. We show that in most of the parameter space of split SUSY-like models squarks and sleptons are heavier than the lightest modulus. Hence dark radiation predictions previously obtained for MSSM-like cases hold more generally also for split SUSY-like cases since the decay channel to SUSY scalars is kinematically forbidden. However the inclusion of string loop corrections to the Kahler potential gives rise to a parameter space region where the decay channel to SUSY scalars opens up, leading to a significant reduction of dark radiation production. ...
Accelerated failure time model under general biased sampling scheme.
Kim, Jane Paik; Sit, Tony; Ying, Zhiliang
2016-07-01
Right-censored time-to-event data are sometimes observed from a (sub)cohort of patients whose survival times can be subject to outcome-dependent sampling schemes. In this paper, we propose a unified estimation method for semiparametric accelerated failure time models under general biased estimating schemes. The proposed estimator of the regression covariates is developed upon a bias-offsetting weighting scheme and is proved to be consistent and asymptotically normally distributed. Large sample properties for the estimator are also derived. Using rank-based monotone estimating functions for the regression parameters, we find that the estimating equations can be easily solved via convex optimization. The methods are confirmed through simulations and illustrated by application to real datasets on various sampling schemes including length-bias sampling, the case-cohort design and its variants. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Calibration of parallel kinematics machine using generalized distance error model
Institute of Scientific and Technical Information of China (English)
无
2007-01-01
This paper focus on the accuracy enhancement of parallel kinematics machine through kinematics calibration. In the calibration processing, well-structured identification Jacobian matrix construction and end-effector position and orientation measurement are two main difficulties. In this paper, the identification Jacobian matrix is constructed easily by numerical calculation utilizing the unit virtual velocity method. The generalized distance errors model is presented for avoiding measuring the position and orientation directly which is difficult to be measured. At last, a measurement tool is given for acquiring the data points in the calibration processing.Experimental studies confirmed the effectiveness of method. It is also shown in the paper that the proposed approach can be applied to other typed parallel manipulators.
A General Random Walk Model of Molecular Motor
Institute of Scientific and Technical Information of China (English)
WANGXian-Ju; AIBao-Quan; LIUGuo-Tao; LIULiang-Gang
2003-01-01
A general random walk model framework is presented which can be used to statistically describe the internal dynamics and external mechanical movement of molecular motors along filament track. The motion of molecular motor in a periodic potential and a constant force is considered. We show that the molecular motor's movement becomes slower with the potential barrier increasing, but if the force is increased, the molecular motor''s movement becomes faster. The relation between the effective rate constant and the potential battler's height, and that between the effective rate constant and the value of the force are discussed. Our results are consistent with the experiments and relevant theoretical consideration, and can be used to explain some physiological phenomena.
Generalized elastic model yields a fractional Langevin equation description.
Taloni, Alessandro; Chechkin, Aleksei; Klafter, Joseph
2010-04-23
Starting from a generalized elastic model which accounts for the stochastic motion of several physical systems such as membranes, (semi)flexible polymers, and fluctuating interfaces among others, we derive the fractional Langevin equation (FLE) for a probe particle in such systems, in the case of thermal initial conditions. We show that this FLE is the only one fulfilling the fluctuation-dissipation relation within a new family of fractional Brownian motion equations. The FLE for the time-dependent fluctuations of the donor-acceptor distance in a protein is shown to be recovered. When the system starts from nonthermal conditions, the corresponding FLE, which does not fulfill the fluctuation-dissipation relation, is derived.
Correlations in a generalized elastic model: fractional Langevin equation approach.
Taloni, Alessandro; Chechkin, Aleksei; Klafter, Joseph
2010-12-01
The generalized elastic model (GEM) provides the evolution equation which governs the stochastic motion of several many-body systems in nature, such as polymers, membranes, and growing interfaces. On the other hand a probe (tracer) particle in these systems performs a fractional Brownian motion due to the spatial interactions with the other system's components. The tracer's anomalous dynamics can be described by a fractional Langevin equation (FLE) with a space-time correlated noise. We demonstrate that the description given in terms of GEM coincides with that furnished by the relative FLE, by showing that the correlation functions of the stochastic field obtained within the FLE framework agree with the corresponding quantities calculated from the GEM. Furthermore we show that the Fox H -function formalism appears to be very convenient to describe the correlation properties within the FLE approach.
dglars: An R Package to Estimate Sparse Generalized Linear Models
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Luigi Augugliaro
2014-09-01
Full Text Available dglars is a publicly available R package that implements the method proposed in Augugliaro, Mineo, and Wit (2013, developed to study the sparse structure of a generalized linear model. This method, called dgLARS, is based on a differential geometrical extension of the least angle regression method proposed in Efron, Hastie, Johnstone, and Tibshirani (2004. The core of the dglars package consists of two algorithms implemented in Fortran 90 to efficiently compute the solution curve: a predictor-corrector algorithm, proposed in Augugliaro et al. (2013, and a cyclic coordinate descent algorithm, proposed in Augugliaro, Mineo, and Wit (2012. The latter algorithm, as shown here, is significantly faster than the predictor-corrector algorithm. For comparison purposes, we have implemented both algorithms.
Generalized cavity model and nonlocal effects in nanoslit arrays
Dechaux, Mathieu; Ciracì, Cristian; Benedicto, Jessica; Pollès, Rémi; Centeno, Emmanuel; Smith, David R; Moreau, Antoine
2016-01-01
Gap-plasmon resonators are a class of nanogap-based plasmonic structures presenting unprecedented optical properties despite a size that can be smaller than the skin depth of metals. In the case of extremely narrow slit arrays, these ultra-small resonators are better described by a generalized cavity model. Moreover, such structures are sensitive to the nonlocal response of the metals arising from interactions between free electrons inside the jellium. This phenomenon actually influences the necessarily intense plasmonic slowdown (very low phase and group velocities) experienced by the gap-plasmon in such tiny cavities. Accurately describing the optical response of this class of structures requires to take all of these effects into account, and will undoubtedly be necessary to design or characterize future gap-plasmon resonators.
Generalized Swept Mid-structure for Polygonal Models
Martin, Tobias
2012-05-01
We introduce a novel mid-structure called the generalized swept mid-structure (GSM) of a closed polygonal shape, and a framework to compute it. The GSM contains both curve and surface elements and has consistent sheet-by-sheet topology, versus triangle-by-triangle topology produced by other mid-structure methods. To obtain this structure, a harmonic function, defined on the volume that is enclosed by the surface, is used to decompose the volume into a set of slices. A technique for computing the 1D mid-structures of these slices is introduced. The mid-structures of adjacent slices are then iteratively matched through a boundary similarity computation and triangulated to form the GSM. This structure respects the topology of the input surface model is a hybrid mid-structure representation. The construction and topology of the GSM allows for local and global simplification, used in further applications such as parameterization, volumetric mesh generation and medical applications.
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Parvaneh Mohammadkhani
2015-03-01
Full Text Available The aim of this study was to evaluate suicide probability in Iranian males with substance abuse or dependence disorder and to investigate the predictors of suicide probability based on trait mindfulness, reasons for living and severity of general psychiatric symptoms.Participants were 324 individuals with substance abuse or dependence in an outpatient setting and prison. Reasons for living questionnaire, Mindfulness Attention Awareness Scale and Suicide probability Scale were used as instruments. Sample was selected based on convenience sampling method. Data were analyzed using SPSS and AMOS.The life-time prevalence of suicide attempt in the outpatient setting was35% and it was 42% in the prison setting. Suicide probability in the prison setting was significantly higher than in the outpatient setting (p<0.001. The severity of general symptom strongly correlated with suicide probability. Trait mindfulness, not reasons for living beliefs, had a mediating effect in the relationship between the severity of general symptoms and suicide probability. Fear of social disapproval, survival and coping beliefs and child-related concerns significantly predicted suicide probability (p<0.001.It could be suggested that trait mindfulness was more effective in preventing suicide probability than beliefs about reasons for living in individuals with substance abuse or dependence disorders. The severity of general symptom should be regarded as an important risk factor of suicide probability.
Hospitable archean climates simulated by a general circulation model.
Wolf, E T; Toon, O B
2013-07-01
Evidence from ancient sediments indicates that liquid water and primitive life were present during the Archean despite the faint young Sun. To date, studies of Archean climate typically utilize simplified one-dimensional models that ignore clouds and ice. Here, we use an atmospheric general circulation model coupled to a mixed-layer ocean model to simulate the climate circa 2.8 billion years ago when the Sun was 20% dimmer than it is today. Surface properties are assumed to be equal to those of the present day, while ocean heat transport varies as a function of sea ice extent. Present climate is duplicated with 0.06 bar of CO2 or alternatively with 0.02 bar of CO2 and 0.001 bar of CH4. Hot Archean climates, as implied by some isotopic reconstructions of ancient marine cherts, are unattainable even in our warmest simulation having 0.2 bar of CO2 and 0.001 bar of CH4. However, cooler climates with significant polar ice, but still dominated by open ocean, can be maintained with modest greenhouse gas amounts, posing no contradiction with CO2 constraints deduced from paleosols or with practical limitations on CH4 due to the formation of optically thick organic hazes. Our results indicate that a weak version of the faint young Sun paradox, requiring only that some portion of the planet's surface maintain liquid water, may be resolved with moderate greenhouse gas inventories. Thus, hospitable late Archean climates are easily obtained in our climate model.
Happee, R.; Morsink, P.L.J.; Lange, R. de; Bours, R.; Ridella, S.; Nayef, A.; Hoof, J. van
2000-01-01
A human body model representing a mid size male has been presented at the 1998 STAPP conference. A combination of modeling techniques was applied using rigid bodies for most segments, but describing the thorax as a deformable structure. In this paper, this modeling strategy was employed to also deve
Varieties of male-sexual-identity development in clinical practice: a neuropsychoanalytic model.
Stortelder, Frans
2014-01-01
Variations of sexual identity development are present in all cultures, as well as in many animal species. Freud - founding father of psychoanalysis - believed that all men have an inherited, bisexual disposition, and that many varieties of love and desire are experienced as alternative pathways to intimacy. In the neuropsychoanalytic model, psychic development starts with the constitutional self. The constitutional self is comprised of the neurobiological factors which contribute to sexual identity development. These neurobiological factors are focused on biphasic sexual organization in the prenatal phase, based on variations in genes, sex hormones, and brain circuits. This psychosocial construction of sexual identity is determined through contingent mirroring by the parents and peers of the constitutional self. The development of the self-or personal identity-is linked with the development of sexual identity, gender-role identity, and procreative identity. Incongruent mirroring of the constitutional self causes alienation in the development of the self. Such alienation can be treated within the psychoanalytic relationship. This article presents a contemporary, neuropsychoanalytic, developmental theory of male-sexual identity relating to varieties in male-sexual-identity development, with implications for psychoanalytic treatment, and is illustrated with three vignettes from clinical practice.
Molecular evolution of candidate male reproductive genes in the brown algal model Ectocarpus.
Lipinska, Agnieszka P; Van Damme, Els J M; De Clerck, Olivier
2016-01-05
Evolutionary studies of genes that mediate recognition between sperm and egg contribute to our understanding of reproductive isolation and speciation. Surface receptors involved in fertilization are targets of sexual selection, reinforcement, and other evolutionary forces including positive selection. This observation was made across different lineages of the eukaryotic tree from land plants to mammals, and is particularly evident in free-spawning animals. Here we use the brown algal model species Ectocarpus (Phaeophyceae) to investigate the evolution of candidate gamete recognition proteins in a distant major phylogenetic group of eukaryotes. Male gamete specific genes were identified by comparing transcriptome data covering different stages of the Ectocarpus life cycle and screened for characteristics expected from gamete recognition receptors. Selected genes were sequenced in a representative number of strains from distant geographical locations and varying stages of reproductive isolation, to search for signatures of adaptive evolution. One of the genes (Esi0130_0068) showed evidence of selective pressure. Interestingly, that gene displayed domain similarities to the receptor for egg jelly (REJ) protein involved in sperm-egg recognition in sea urchins. We have identified a male gamete specific gene with similarity to known gamete recognition receptors and signatures of adaptation. Altogether, this gene could contribute to gamete interaction during reproduction as well as reproductive isolation in Ectocarpus and is therefore a good candidate for further functional evaluation.
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Zhi-Yuan Zhang
2017-01-01
Full Text Available Androgen deficiency is a physical disorder that not only affects adults but can also jeopardize children′s health. Because there are many disadvantages to using traditional androgen replacement therapy, we have herein attempted to explore the use of human umbilical cord mesenchymal stem cells for the treatment of androgen deficiency. We transplanted CM-Dil-labeled human umbilical cord mesenchymal stem cells into the testes of an ethane dimethanesulfonate (EDS-induced male rat hypogonadism model. Twenty-one days after transplantation, we found that blood testosterone levels in the therapy group were higher than that of the control group (P = 0.037, and using immunohistochemistry and flow cytometry, we observed that some of the CM-Dil-labeled cells expressed Leydig cell markers for cytochrome P450, family 11, subfamily A, polypeptide 1, and 3-β-hydroxysteroid dehydrogenase. We then recovered these cells and observed that they were still able to proliferate in vitro. The present study shows that mesenchymal stem cells from human umbilical cord may constitute a promising therapeutic modality for the treatment of male hypogonadism patients.
Digital terrain model generalization incorporating scale, semantic and cognitive constraints
Partsinevelos, Panagiotis; Papadogiorgaki, Maria
2014-05-01
Cartographic generalization is a well-known process accommodating spatial data compression, visualization and comprehension under various scales. In the last few years, there are several international attempts to construct tangible GIS systems, forming real 3D surfaces using a vast number of mechanical parts along a matrix formation (i.e., bars, pistons, vacuums). Usually, moving bars upon a structured grid push a stretching membrane resulting in a smooth visualization for a given surface. Most of these attempts suffer either in their cost, accuracy, resolution and/or speed. Under this perspective, the present study proposes a surface generalization process that incorporates intrinsic constrains of tangible GIS systems including robotic-motor movement and surface stretching limitations. The main objective is to provide optimized visualizations of 3D digital terrain models with minimum loss of information. That is, to minimize the number of pixels in a raster dataset used to define a DTM, while reserving the surface information. This neighborhood type of pixel relations adheres to the basics of Self Organizing Map (SOM) artificial neural networks, which are often used for information abstraction since they are indicative of intrinsic statistical features contained in the input patterns and provide concise and characteristic representations. Nevertheless, SOM remains more like a black box procedure not capable to cope with possible particularities and semantics of the application at hand. E.g. for coastal monitoring applications, the near - coast areas, surrounding mountains and lakes are more important than other features and generalization should be "biased"-stratified to fulfill this requirement. Moreover, according to the application objectives, we extend the SOM algorithm to incorporate special types of information generalization by differentiating the underlying strategy based on topologic information of the objects included in the application. The final
Yavari, Morteza
2014-02-01
The aim of this paper is to generalize the results of the Feoli's formalism (A. Feoli et al., Nucl. Phys. B 705, 577 (2005)) for DNA structures. The exact solutions of the general equilibrium shape equations for a general power model of free energy are investigated using the Feoli's formalism. The free energy of B- to Z-DNA transition is also calculated in this formalism.
Intraseasonal Variability in an Aquaplanet General Circulation Model
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Adam H Sobel
2010-04-01
Full Text Available An aquaplanet atmospheric general circulation model simulation with a robust intraseasonal oscillation is analyzed. The SST boundary condition resembles the observed December-April average with continents omitted, although with the meridional SST gradient reduced to be one-quarter of that observed poleward of 10 ̊ latitude. Slow, regular eastward propagation at 5 m s21 in winds and precipitation with amplitude greater than that in the observed MJO is clearly identified in unfiltered fields. Local precipitation rate is a strongly non-linear and increasing function of column precipitable water, as in observations. The model intraseasonal oscillation resembles a moisture mode that is destabilized by wind-evaporation feedback, and that propagates eastward through advection of anomalous humidity by the sum of perturbation winds and mean westerly flow. A series of sensitivity experiments are conducted to test hypothesized mechanisms. A mechanism denial experiment in which intraseasonal latent heat flux variability is removed largely eliminates intraseasonal wind and precipitation variability. Reducing the lower-troposphere westerly flow in the warm pool by reducing the zonal SST gradient slows eastward propagation, supporting the importance of horizontal advection by the low-level wind to eastward propagation. A zonally symmetric SST basic state produces weak and unrealistic intraseasonal variability between 30 and 90 day timescales, indicating the importance of mean low-level westerly winds and hence a realistic phase relationship between precipitation and surface flux anomalies for producing realistic tropical intraseasonal variability.
Cognitive performance modeling based on general systems performance theory.
Kondraske, George V
2010-01-01
General Systems Performance Theory (GSPT) was initially motivated by problems associated with quantifying different aspects of human performance. It has proved to be invaluable for measurement development and understanding quantitative relationships between human subsystem capacities and performance in complex tasks. It is now desired to bring focus to the application of GSPT to modeling of cognitive system performance. Previous studies involving two complex tasks (i.e., driving and performing laparoscopic surgery) and incorporating measures that are clearly related to cognitive performance (information processing speed and short-term memory capacity) were revisited. A GSPT-derived method of task analysis and performance prediction termed Nonlinear Causal Resource Analysis (NCRA) was employed to determine the demand on basic cognitive performance resources required to support different levels of complex task performance. This approach is presented as a means to determine a cognitive workload profile and the subsequent computation of a single number measure of cognitive workload (CW). Computation of CW may be a viable alternative to measuring it. Various possible "more basic" performance resources that contribute to cognitive system performance are discussed. It is concluded from this preliminary exploration that a GSPT-based approach can contribute to defining cognitive performance models that are useful for both individual subjects and specific groups (e.g., military pilots).
A Comparison of Generalized Hyperbolic Distribution Models for Equity Returns
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Virginie Konlack Socgnia
2014-01-01
Full Text Available We discuss the calibration of the univariate and multivariate generalized hyperbolic distributions, as well as their hyperbolic, variance gamma, normal inverse Gaussian, and skew Student’s t-distribution subclasses for the daily log-returns of seven of the most liquid mining stocks listed on the Johannesburg Stocks Exchange. To estimate the model parameters from historic distributions, we use an expectation maximization based algorithm for the univariate case and a multicycle expectation conditional maximization estimation algorithm for the multivariate case. We assess the goodness of fit statistics using the log-likelihood, the Akaike information criterion, and the Kolmogorov-Smirnov distance. Finally, we inspect the temporal stability of parameters and note implications as criteria for distinguishing between models. To better understand the dependence structure of the stocks, we fit the MGHD and subclasses to both the stock returns and the two leading principal components derived from the price data. While the MGHD could fit both data subsets, we observed that the multivariate normality of the stock return residuals, computed by removing shared components, suggests that the departure from normality can be explained by the structure in the common factors.
A general model of the public goods dilemma.
Frank, Steven A
2010-06-01
An individually costly act that benefits all group members is a public good. Natural selection favours individual contribution to public good [corrected] only when some benefit to the individual offsets the cost of contribution. Problems of sex ratio, parasite virulence, microbial metabolism, punishment of noncooperators, and nearly all aspects of sociality have been analysed as public goods shaped by kin and group selection. Here, I develop two general aspects of the public goods problem that have received relatively little attention. First, variation in individual resources favours selfish individuals to vary their allocation to public goods. Those individuals better endowed contribute their excess resources to public benefit, whereas those individuals with fewer resources contribute less to the public good. Thus, purely selfish behaviour causes individuals to stratify into upper classes that contribute greatly to public benefit and social cohesion and to lower classes that contribute little to the public good. Second, if group success absolutely requires production of the public good, then the pressure favouring production is relatively high. By contrast, if group success depends weakly on the public good, then the pressure favouring production is relatively weak. Stated in this way, it is obvious that the role of baseline success is important. However, discussions of public goods problems sometimes fail to emphasize this point sufficiently. The models here suggest simple tests for the roles of resource variation and baseline success. Given the widespread importance of public goods, better models and tests would greatly deepen our understanding of many processes in biology and sociality.
Kubo Fluctuation Relations in the Generalized Elastic Model
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Alessandro Taloni
2016-01-01
Full Text Available The generalized elastic model encompasses several linear stochastic models describing the dynamics of polymers, membranes, rough surfaces, and fluctuating interfaces. In this paper we show that the Fractional Langevin Equation (FLE is a suitable framework for the study of the tracer (probe particle dynamics, when an external force acts only on a single point x→⋆ (tagged probe belonging to the system. With the help of the Fox function formalism we study the scaling behaviour of the noise- and force-propagators for large and short times (distances. We show that the Kubo fluctuation relations are exactly fulfilled when a time periodic force is exerted on the tagged probe. Most importantly, by studying the large and low frequency behaviour of the complex mobility we illustrate surprising nontrivial physical scenarios. Our analysis shows that the system splits into two distinct regions whose size depends on the applied frequency, characterized by very different response to the periodic perturbation exerted, both in the phase shift and in the amplitude.
Chain-Wise Generalization of Road Networks Using Model Selection
Bulatov, D.; Wenzel, S.; Häufel, G.; Meidow, J.
2017-05-01
Streets are essential entities of urban terrain and their automatized extraction from airborne sensor data is cumbersome because of a complex interplay of geometric, topological and semantic aspects. Given a binary image, representing the road class, centerlines of road segments are extracted by means of skeletonization. The focus of this paper lies in a well-reasoned representation of these segments by means of geometric primitives, such as straight line segments as well as circle and ellipse arcs. We propose the fusion of raw segments based on similarity criteria; the output of this process are the so-called chains which better match to the intuitive perception of what a street is. Further, we propose a two-step approach for chain-wise generalization. First, the chain is pre-segmented using circlePeucker and finally, model selection is used to decide whether two neighboring segments should be fused to a new geometric entity. Thereby, we consider both variance-covariance analysis of residuals and model complexity. The results on a complex data-set with many traffic roundabouts indicate the benefits of the proposed procedure.
Generalized Functional Linear Models With Semiparametric Single-Index Interactions
Li, Yehua
2010-06-01
We introduce a new class of functional generalized linear models, where the response is a scalar and some of the covariates are functional. We assume that the response depends on multiple covariates, a finite number of latent features in the functional predictor, and interaction between the two. To achieve parsimony, the interaction between the multiple covariates and the functional predictor is modeled semiparametrically with a single-index structure. We propose a two step estimation procedure based on local estimating equations, and investigate two situations: (a) when the basis functions are pre-determined, e.g., Fourier or wavelet basis functions and the functional features of interest are known; and (b) when the basis functions are data driven, such as with functional principal components. Asymptotic properties are developed. Notably, we show that when the functional features are data driven, the parameter estimates have an increased asymptotic variance, due to the estimation error of the basis functions. Our methods are illustrated with a simulation study and applied to an empirical data set, where a previously unknown interaction is detected. Technical proofs of our theoretical results are provided in the online supplemental materials.
Critical rotation of general-relativistic polytropic models revisited
Geroyannis, V.; Karageorgopoulos, V.
2013-09-01
We develop a perturbation method for computing the critical rotational parameter as a function of the equatorial radius of a rigidly rotating polytropic model in the "post-Newtonia approximation" (PNA). We treat our models as "initial value problems" (IVP) of ordinary differential equations in the complex plane. The computations are carried out by the code dcrkf54.f95 (Geroyannis and Valvi 2012 [P1]; modified Runge-Kutta-Fehlberg code of fourth and fifth order for solving initial value problems in the complex plane). Such a complex-plane treatment removes the syndromes appearing in this particular family of IVPs (see e.g. P1, Sec. 3) and allows continuation of the numerical integrations beyond the surface of the star. Thus all the required values of the Lane-Emden function(s) in the post-Newtonian approximation are calculated by interpolation (so avoiding any extrapolation). An interesting point is that, in our computations, we take into account the complete correction due to the gravitational term, and this issue is a remarkable difference compared to the classical PNA. We solve the generalized density as a function of the equatorial radius and find the critical rotational parameter. Our computations are extended to certain other physical characteristics (like mass, angular momentum, rotational kinetic energy, etc). We find that our method yields results comparable with those of other reliable methods. REFERENCE: V.S. Geroyannis and F.N. Valvi 2012, International Journal of Modern Physics C, 23, No 5, 1250038:1-15.
Despotic societies, sexual attraction and the emergence of male 'tolerance': An agent-based model
Hemelrijk, C.K.
2002-01-01
During the period when females are sexually attractive - but only then - males of certain species of primates, such as chimpanzees, allow females access to resources. Because males are usually dominant over females, such male 'tolerance' is explained as a special, reproductive strategy to gain
Xie, Tianwu; Kuster, Niels; Zaidi, Habib
2017-08-01
Computational phantoms are commonly used in internal radiation dosimetry to assess the amount and distribution pattern of energy deposited in various parts of the human body from different internal radiation sources. Radiation dose assessments are commonly performed on predetermined reference computational phantoms while the argument for individualized patient-specific radiation dosimetry exists. This study aims to evaluate the influence of body habitus on internal dosimetry and to quantify the uncertainties in dose estimation correlated with the use of fixed reference models. The 5-year-old IT’IS male phantom was modified to match target anthropometric parameters, including body weight, body height and sitting height/stature ratio (SSR), determined from reference databases, thus enabling the creation of 125 5-year-old habitus-dependent male phantoms with 10th, 25th, 50th, 75th and 90th percentile body morphometries. We evaluated the absorbed fractions and the mean absorbed dose to the target region per unit cumulative activity in the source region (S-values) of F-18 in 46 source regions for the generated 125 anthropomorphic 5-year-old hybrid male phantoms using the Monte Carlo N-Particle eXtended general purpose Monte Carlo transport code and calculated the absorbed dose and effective dose of five 18F-labelled radiotracers for children of various habitus. For most organs, the S-value of F-18 presents stronger statistical correlations with body weight, standing height and sitting height than BMI and SSR. The self-absorbed fraction and self-absorbed S-values of F-18 and the absorbed dose and effective dose of 18F-labelled radiotracers present with the strongest statistical correlations with body weight. For 18F-Amino acids, 18F-Brain receptor substances, 18F-FDG, 18F-L-DOPA and 18F-FBPA, the mean absolute effective dose differences between phantoms of different habitus and fixed reference models are 11.4%, 11.3%, 10.8%, 13.3% and 11.4%, respectively. Total body
Inagaki, Hideaki; Kiyokawa, Yasushi; Takeuchi, Yukari; Mori, Yuji
2010-02-01
Previously, we demonstrated that an alarm pheromone released from male donor Wistar rats evoked anxiety-related physiological and behavioral responses in recipient rats. Thus, we believe that this pheromone may increase anxiety levels in rats. In the current study, we evaluated the predictive validity of this alarm pheromone-induced anxiogenic effect in detail by investigating whether six types of human anxiolytics, each of which has a different mechanism of action, were efficacious in reducing anxiety, using changes in the acoustic startle reflex (ASR) as an index. The alarm pheromone-enhanced ASR was not affected by vehicle pretreatment but was dose-dependently attenuated by pretreatment with midazolam, phenelzine, propranolol, clonidine, and CP-154,526-although not buspirone. These results may reflect some aspects of the predictive validity of the alarm pheromone-induced anxiety in rats as an animal model of human anxiety.
Computable General Equilibrium Techniques for Carbon Tax Modeling
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Al-Amin
2009-01-01
Full Text Available Problem statement: Lacking of proper environmental models environmental pollution is now a solemn problem in many developing countries particularly in Malaysia. Some empirical studies of worldwide reveal that imposition of a carbon tax significantly decreases carbon emissions and does not dramatically reduce economic growth. To our knowledge there has not been any research done to simulate the economic impact of emission control policies in Malaysia. Approach: Therefore this study developed an environmental computable general equilibrium model for Malaysia and investigated carbon tax policy responses in the economy applying exogenously different degrees of carbon tax into the model. Three simulations were carried out using a Malaysian social accounting matrix. Results: The carbon tax policy illustrated that a 1.21% reduction of carbon emission reduced the nominal GDP by 0.82% and exports by 2.08%; 2.34% reduction of carbon emission reduced the nominal GDP by 1.90% and exports by 3.97% and 3.40% reduction of carbon emission reduced the nominal GDP by 3.17% and exports by 5.71%. Conclusion/Recommendations: Imposition of successively higher carbon tax results in increased government revenue from baseline by 26.67, 53.07 and 79.28% respectively. However, fixed capital investment increased in scenario 1a by 0.43% and decreased in scenarios 1b and 1c by 0.26 and 1.79% respectively from the baseline. According to our policy findings policy makers should consider 1st (scenario 1a carbon tax policy. This policy results in achieving reasonably good environmental impacts without losing the investment, fixed capital investment, investment share of nominal GDP and government revenue.
Efficient decoding algorithms for generalized hidden Markov model gene finders
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Delcher Arthur L
2005-01-01
Full Text Available Abstract Background The Generalized Hidden Markov Model (GHMM has proven a useful framework for the task of computational gene prediction in eukaryotic genomes, due to its flexibility and probabilistic underpinnings. As the focus of the gene finding community shifts toward the use of homology information to improve prediction accuracy, extensions to the basic GHMM model are being explored as possible ways to integrate this homology information into the prediction process. Particularly prominent among these extensions are those techniques which call for the simultaneous prediction of genes in two or more genomes at once, thereby increasing significantly the computational cost of prediction and highlighting the importance of speed and memory efficiency in the implementation of the underlying GHMM algorithms. Unfortunately, the task of implementing an efficient GHMM-based gene finder is already a nontrivial one, and it can be expected that this task will only grow more onerous as our models increase in complexity. Results As a first step toward addressing the implementation challenges of these next-generation systems, we describe in detail two software architectures for GHMM-based gene finders, one comprising the common array-based approach, and the other a highly optimized algorithm which requires significantly less memory while achieving virtually identical speed. We then show how both of these architectures can be accelerated by a factor of two by optimizing their content sensors. We finish with a brief illustration of the impact these optimizations have had on the feasibility of our new homology-based gene finder, TWAIN. Conclusions In describing a number of optimizations for GHMM-based gene finders and making available two complete open-source software systems embodying these methods, it is our hope that others will be more enabled to explore promising extensions to the GHMM framework, thereby improving the state-of-the-art in gene prediction
Design and implementation of a generalized laboratory data model
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Nhan Mike
2007-09-01
Full Text Available Abstract Background Investigators in the biological sciences continue to exploit laboratory automation methods and have dramatically increased the rates at which they can generate data. In many environments, the methods themselves also evolve in a rapid and fluid manner. These observations point to the importance of robust information management systems in the modern laboratory. Designing and implementing such systems is non-trivial and it appears that in many cases a database project ultimately proves unserviceable. Results We describe a general modeling framework for laboratory data and its implementation as an information management system. The model utilizes several abstraction techniques, focusing especially on the concepts of inheritance and meta-data. Traditional approaches commingle event-oriented data with regular entity data in ad hoc ways. Instead, we define distinct regular entity and event schemas, but fully integrate these via a standardized interface. The design allows straightforward definition of a "processing pipeline" as a sequence of events, obviating the need for separate workflow management systems. A layer above the event-oriented schema integrates events into a workflow by defining "processing directives", which act as automated project managers of items in the system. Directives can be added or modified in an almost trivial fashion, i.e., without the need for schema modification or re-certification of applications. Association between regular entities and events is managed via simple "many-to-many" relationships. We describe the programming interface, as well as techniques for handling input/output, process control, and state transitions. Conclusion The implementation described here has served as the Washington University Genome Sequencing Center's primary information system for several years. It handles all transactions underlying a throughput rate of about 9 million sequencing reactions of various kinds per month and
A stylized computational model of the head for the reference Japanese male.
Yamauchi, M; Ishikawa, M; Hoshi, M
2005-01-01
Computational models of human anatomy, along with Monte Carlo radiation transport simulations, have been used by Snyder et al. [MIRD Pamphlet No. 5, revised (The Society of Nuclear Medicine, New York, 1978)], Cristy and Eckerman [ORNL/TM-8381/VI, Oak Ridge National Laboratory, Oak Ridge, TN (1987)] and Zubal et al. [Med. Phys. 21, 299-302 (1994)] to estimate internal organ doses from internal and external radiation sources. These were created using physiological data from Caucasoid subjects but not from other races. There is a need for research to determine whether the obvious differences from the Caucasoid anatomy make these models unsuitable for estimating the absorbed dose in other races such as the Mongoloid. We used the cranial region of the adult Japanese male to represent the Mongoloid race. This region contains organs that are highly sensitive to radiation. The cranial region of a physical phantom produced by KYOTO KAGAKU Co., LTD. using numerical data from a Japanese Reference Man [Tanaka, Nippon Acta. Radiol. 48, 509-513 (1988)] was used to supply the data for the geometry of a stylized computational model. Our computational model was constructed with equations rather than voxel-based, in order to deal with as small a number of parameters as possible in the computer simulation experiment. The accuracy of our computational model was checked by comparing simulated experimental results obtained with MCNP4C with actual doses measured with thermoluminescence dosimeters (TLDs) inside the physical phantom from which our computational model was constructed. The TLDs, whose margin of error is less than +/-10%, were arranged at six positions. Co-60 was used as the radiation source. The irradiated dose was 2 Gy in terms of air kerma. In the computer simulation experiments, we used our computational model and Cristy's computational model, whose component data are those of the tissue substitute materials and of the human body as published in ICRU Report 46. The
Respiratory Tract Lung Geometry and Dosimetry Model for Male Sprague-Dawley Rats
Energy Technology Data Exchange (ETDEWEB)
Miller, Frederick J.; Asgharian, Bahman; Schroeter, Jeffry D.; Price, Owen; Corley, Richard A.; Einstein, Daniel R.; Jacob, Rick E.; Cox, Timothy C.; Kabilan, Senthil; Bentley, Timothy
2015-07-24
While inhalation toxicological studies of various compounds have been conducted using a number of different strains of rats, mechanistic dosimetry models have only had tracheobronchial (TB) structural data for Long-Evans rats, detailed morphometric data on the alveolar region of Sprague-Dawley rats and limited alveolar data on other strains. Based upon CT imaging data for two male Sprague-Dawley rats, a 15-generation, symmetric typical path model was developed for the TB region. Literature data for the alveolar region of Sprague-Dawley rats were analyzed to develop an eight-generation model, and the two regions were joined to provide a complete lower respiratory tract model for Sprague-Dawley rats. The resulting lung model was used to examine particle deposition in Sprague-Dawley rats and to compare these results with predicted deposition in Long-Evans rats. Relationships of various physiologic variables and lung volumes were either developed in this study or extracted from the literature to provide the necessary input data for examining particle deposition. While the lengths, diameters and branching angles of the TB airways differed between the two Sprague-Dawley rats, the predicted deposition patterns in the three major respiratory tract regions were very similar. Between Sprague-Dawley and Long-Evans rats, significant differences in TB and alveolar predicted deposition fractions were observed over a wide range of particle sizes, with TB deposition fractions being up to 3- to 4-fold greater in Sprague-Dawley rats and alveolar deposition being significantly greater in Long-Evans rats. Thus, strain-specific lung geometry models should be used for particle deposition calculations and interspecies dose comparisons.
Maximum Likelihood in a Generalized Linear Finite Mixture Model by Using the EM Algorithm
Jansen, R.C.
A generalized linear finite mixture model and an EM algorithm to fit the model to data are described. By this approach the finite mixture model is embedded within the general framework of generalized linear models (GLMs). Implementation of the proposed EM algorithm can be readily done in statistical
Age-period-cohort models using smoothing splines: a generalized additive model approach.
Jiang, Bei; Carriere, Keumhee C
2014-02-20
Age-period-cohort (APC) models are used to analyze temporal trends in disease or mortality rates, dealing with linear dependency among associated effects of age, period, and cohort. However, the nature of sparseness in such data has severely limited the use of APC models. To deal with these practical limitations and issues, we advocate cubic smoothing splines. We show that the methods of estimable functions proposed in the framework of generalized linear models can still be considered to solve the non-identifiability problem when the model fitting is within the framework of generalized additive models with cubic smoothing splines. Through simulation studies, we evaluate the performance of the cubic smoothing splines in terms of the mean squared errors of estimable functions. Our results support the use of cubic smoothing splines for APC modeling with sparse but unaggregated data from a Lexis diagram.
Grunz-Borgmann, Elizabeth A; Nichols, LaNita A; Wiedmeyer, Charles E; Spagnoli, Sean; Trzeciakowski, Jerome P; Parrish, Alan R
2016-06-01
The male Fischer 344 rat is an established model to study progressive renal dysfunction that is similar, but not identical, to chronic kidney disease (CKD) in humans. These studies were designed to assess age-dependent alterations in renal structure and function at late-life timepoints, 16-24 months. Elevations in BUN and plasma creatinine were not significant until 24 months, however, elevations in the more sensitive markers of function, plasma cystatin C and proteinuria, were detectable at 16 and 18 months, respectively. Interestingly, cystatin C levels were not corrected by caloric restriction. Urinary Kim-1, a marker of CKD, was elevated as early as 16 months. Klotho gene expression was significantly decreased at 24 months, but not at earlier timepoints. Alterations in renal structure, glomerulosclerosis and tubulointerstitial fibrosis, were noted at 16 months, with little change from 18 to 24 months. Tubulointerstitial inflammation was increased at 16 months, and remained similar from 18 to 24 months. A SEM (structural equation modeling) model of age-related renal dysfunction suggests that proteinuria is a marker of renal damage, while urinary Kim-1 is a marker of both damage and function. Taken together, these results demonstrate that age-dependent nephropathy begins as early as 16 months and progresses rapidly over the next 8 months.
Specificity of Metabolic Syndrome Model Reproduction at Pubertal and Adult Male Rats
Directory of Open Access Journals (Sweden)
Bondarenko Larysa Borysivna
2015-09-01
Full Text Available Background and Aims: Comparative estimation of metabolic syndrome (MS mediated changes of blood, cardio-vascular system, liver, pancreas and kidneys morphologic structure in adult and pubertal rats. Materials and Methods: Wistar albino male rats of two age categories (young animals of 21 days age (50-70g and adults (160-180g were divided into 4 groups (8 animals in each: 1 - Control 1 (intact young rats; 2 - Control 2 (intact adult rats; 3 - MS3 (young rats with MS and 4 - MS4 (adult rats with MS. The metabolic syndrome model was induced by full replacement of drinking water with 20% fructose solution (200g/l. After 60 days of MS modeling, determination of rat hematological and serum biochemical parameters, glucose tolerance, blood pressure, liver rates of lipid peroxydation and chromatin DNA fragmentation, as well as morphological macroscopic and microscopic studies were carried out. Results: In pubertal rats, glucose tolerance, hypertension, blood clotting disturbances, DNAfragmentation and lipid peroxydation rates were affected more profoundly, while mature rats showed greater Pseudo Pelger-Huet anomaly development, serum cholesterol and lipoproteins increases, liver and kidney morphology changes. Conclusions: Our current data combined with previous results of other authors allow us to conclude that an animal model (Wistar rats of MS is quite easily obtained in a full age range, from juvenile to mature rats.
Gillespie, Nathan A; Neale, Michael C; Jacobson, Kristen; Kendler, Kenneth S
2009-01-01
Background Peer group deviance (PGD) is strongly linked to liability to drug use including cannabis. Our aim was to model the genetic and environmental association, including direction of causation, between PGD and cannabis use (CU). Method Results were based on 1753 adult males from the Mid-Atlantic Twin Registry with complete CU and PGD data measured retrospectively at three time intervals between 15 and 25 years using a life-history calendar. Results At all ages, multivariate modeling showed that familial aggregation in PGD was explained by a combination of additive genetic and shared environmental effects, Moreover the significant PGD-CU association was best explained by a CU to PGD causal model in which large portions of the additive genetic (50% to 78%) and shared environmental variance (25% to 73%) in PGD were explained by CU. Conclusions Until recently PGD was assumed to be an environmental, upstream risk factor for CU. Our data are not consistent with this hypothesis. Rather, they suggest that the liability to affiliate with deviant peers is better explained by a combination of genetic and environmental factors that are indexed by CU which sits as a “risk indicator” in the causal pathway between genetic and environmental risks and the expression of PGD. This is consistent with a process of social selection by which the genetic and environmental risks in CU largely drive the propensity to affiliate with deviant peers. PMID:19207350
Investigation of the mass distribution of a detailed seated male finite element model.
Vavalle, Nicholas A; Thompson, A Bradley; Hayes, Ashley R; Moreno, Daniel P; Stitzel, Joel D; Gayzik, F Scott
2014-06-01
Accurate mass distribution in computational human body models is essential for proper kinematic and kinetic simulations. The purpose of this study was to investigate the mass distribution of a 50th percentile male (M50) full body finite element model (FEM) in the seated position. The FEM was partitioned into 10 segments, using segment planes constructed from bony landmarks per the methods described in previous research studies. Body segment masses and centers of gravity (CGs) of the FEM were compared with values found from these studies, which unlike the present work assumed homogeneous body density. Segment masses compared well to literature while CGs showed an average deviation of 6.0% to 7.0% when normalized by regional characteristic lengths. The discrete mass distribution of the FEM appears to affect the mass and CGs of some segments, particularly those with low-density soft tissues. The locations of the segment CGs are provided in local coordinate systems, thus facilitating comparison with other full body FEMs and human surrogates. The model provides insights into the effects of inhomogeneous mass on the location of body segment CGs.
Pilotto, Isabel L.; Chou, Sin Chan; Nobre, Paulo
2012-12-01
This work evaluates the added value of the downscaling technique employed with the Eta model nested in the CPTEC atmospheric general circulation model and in the CPTEC coupled ocean-atmosphere general circulation model (CGCM). The focus is on the austral summer season, December-January-February, with three members each year. Precipitation, latent heat flux, and shortwave radiation flux at the surface hindcast by the models are compared with observational data and model analyses. The global models generally overestimate the precipitation over South America and tropical Atlantic. The CGCM and the nested Eta (Eta + C) both produce a split in the ITCZ precipitation band. The Eta + C produces better precipitation pattern for the studied season. The Eta model reduces the excessive latent heat flux generated by these global models, in particular the Eta + C. Comparison against PIRATA buoys data shows that the Eta + C results in the smallest precipitation and shortwave radiation forecast errors. The Eta + C comparatively best results are though as a consequence of both: the regional model resolution/physics and smaller errors on the lateral boundary conditions provided by the CGCM.
A Simplified Scheme of the Generalized Layered Radiative Transfer Model
Institute of Scientific and Technical Information of China (English)
无
2007-01-01
In this paper, firstly, a simplified version (SGRTM) of the generalized layered radiative transfer model (GRTM) within the canopy, developed by us, is presented. It reduces the information requirement of inputted sky diffuse radiation, as well as of canopy morphology, and in turn saves computer resources. Results from the SGRTM agree perfectly with those of the GRTM. Secondly, by applying the linear superposition principle of the optics and by using the basic solutions of the GRTM for radiative transfer within the canopy under the condition of assumed zero soil reflectance, two sets of explicit analytical solutions of radiative transfer within the canopy with any soil reflectance magnitude are derived: one for incident diffuse, and the other for direct beam radiation. The explicit analytical solutions need two sets of basic solutions of canopy reflectance and transmittance under zero soil reflectance, run by the model for both diffuse and direct beam radiation. One set of basic solutions is the canopy reflectance αf (written as α1 for direct beam radiation) and transmittance βf (written as β1 for direction beam radiation) with zero soil reflectance for the downward radiation from above the canopy (i.e. sky), and the other set is the canopy reflectance (αb) and transmittanceβb for the upward radiation from below the canopy (i.e., ground). Under the condition of the same plant architecture in the vertical layers, and the same leaf adaxial and abaxial optical properties in the canopies for the uniform diffuse radiation, the explicit solutions need only one set of basic solutions, because under this condition the two basic solutions are equal, i.e., αf = αb and βf = βb. Using the explicit analytical solutions, the fractions of any kind of incident solar radiation reflected from (defined as surface albedo, or canopy reflectance),transmitted through (defined as canopy transmittance), and absorbed by (defined as canopy absorptance)the canopy and other properties
Multi-year predictability in a coupled general circulation model
Energy Technology Data Exchange (ETDEWEB)
Power, Scott; Colman, Rob [Bureau of Meteorology Research Centre, Melbourne, VIC (Australia)
2006-02-01
Multi-year to decadal variability in a 100-year integration of a BMRC coupled atmosphere-ocean general circulation model (CGCM) is examined. The fractional contribution made by the decadal component generally increases with depth and latitude away from surface waters in the equatorial Indo-Pacific Ocean. The relative importance of decadal variability is enhanced in off-equatorial ''wings'' in the subtropical eastern Pacific. The model and observations exhibit ''ENSO-like'' decadal patterns. Analytic results are derived, which show that the patterns can, in theory, occur in the absence of any predictability beyond ENSO time-scales. In practice, however, modification to this stochastic view is needed to account for robust differences between ENSO-like decadal patterns and their interannual counterparts. An analysis of variability in the CGCM, a wind-forced shallow water model, and a simple mixed layer model together with existing and new theoretical results are used to improve upon this stochastic paradigm and to provide a new theory for the origin of decadal ENSO-like patterns like the Interdecadal Pacific Oscillation and Pacific Decadal Oscillation. In this theory, ENSO-driven wind-stress variability forces internal equatorially-trapped Kelvin waves that propagate towards the eastern boundary. Kelvin waves can excite reflected internal westward propagating equatorially-trapped Rossby waves (RWs) and coastally-trapped waves (CTWs). CTWs have no impact on the off-equatorial sub-surface ocean outside the coastal wave guide, whereas the RWs do. If the frequency of the incident wave is too high, then only CTWs are excited. At lower frequencies, both CTWs and RWs can be excited. The lower the frequency, the greater the fraction of energy transmitted to RWs. This lowers the characteristic frequency of variability off the equator relative to its equatorial counterpart. Both the eastern boundary interactions and the accumulation of
Venusian Polar Vortex reproduced by a general circulation model
Ando, Hiroki; Sugimoto, Norihiko; Takagi, Masahiro
2016-10-01
Unlike the polar vortices observed in the Earth, Mars and Titan atmospheres, the observed Venus polar vortex is warmer than the mid-latitudes at cloud-top levels (~65 km). This warm polar vortex is zonally surrounded by a cold latitude band located at ~60 degree latitude, which is a unique feature called 'cold collar' in the Venus atmosphere [e.g. Taylor et al. 1980; Piccioni et al. 2007]. Although these structures have been observed in numerous previous observations, the formation mechanism is still unknown. In addition, an axi-asymmetric feature is always seen in the warm polar vortex. It changes temporally and sometimes shows a hot polar dipole or S-shaped structure as shown by a lot of infrared measurements [e.g. Garate-Lopez et al. 2013; 2015]. However, its vertical structure has not been investigated. To solve these problems, we performed a numerical simulation of the Venus atmospheric circulation using a general circulation model named AFES for Venus [Sugimoto et al. 2014] and reproduced these puzzling features.And then, the reproduced structures of the atmosphere and the axi-asymmetirc feature are compared with some previous observational results.In addition, the quasi-periodical zonal-mean zonal wind fluctuation is also seen in the Venus polar vortex reproduced in our model. This might be able to explain some observational results [e.g. Luz et al. 2007] and implies that the polar vacillation might also occur in the Venus atmosphere, which is silimar to the Earth's polar atmosphere. We will also show some initial results about this point in this presentation.
Lippa, Richard A
2013-02-01
Do self-identified bisexual men and women actually show bisexual patterns of sexual attraction and interest? To answer this question, I studied bisexual men's and women's sexual attraction to photographed male and female "swimsuit models" that varied in attractiveness. Participants (663 college students and gay pride attendees, including 14 self-identified bisexual men and 17 self-identified bisexual women) rated their degree of sexual attraction to 34 male and 34 female swimsuit models. Participants' viewing times to models were unobtrusively assessed. Results showed that bisexual men and women showed bisexual patterns of attraction and viewing times to photo models, which strongly distinguished them from same-sex heterosexual and homosexual participants. In contrast to other groups, which showed evidence of greater male than female category specificity, bisexual men and women did not differ in category specificity. Results suggest that there are subsets of men and women who display truly bisexual patterns of sexual attraction and interest.
Epidemic extinction in a generalized susceptible-infected-susceptible model
Chen, Hanshuang; Huang, Feng; Zhang, Haifeng; Li, Guofeng
2017-01-01
We study the extinction of epidemics in a generalized susceptible-infected-susceptible model, where a susceptible individual becomes infected at the rate λ when contacting m infective individual(s) simultaneously, and an infected individual spontaneously recovers at the rate μ. By employing the Wentzel-Kramers-Brillouin approximation for the master equation, the problem is reduced to finding the zero-energy trajectories in an effective Hamiltonian system, and the mean extinction time depends exponentially on the associated action S and the size of the population N, ˜ \\exp ≤ft(NS\\right) . Because of qualitatively different bifurcation features for m = 1 and m≥slant 2 , we derive independently the expressions of S as a function of the rescaled infection rate λ /μ . For the weak infection, S scales to the distance to the bifurcation with an exponent 2 for m = 1 and 3/2 for m≥slant 2 . Finally, a rare-event simulation method is used to validate the theory.
Generalized linear model for estimation of missing daily rainfall data
Rahman, Nurul Aishah; Deni, Sayang Mohd; Ramli, Norazan Mohamed
2017-04-01
The analysis of rainfall data with no missingness is vital in various applications including climatological, hydrological and meteorological study. The issue of missing data is a serious concern since it could introduce bias and lead to misleading conclusions. In this study, five imputation methods including simple arithmetic average, normal ratio method, inverse distance weighting method, correlation coefficient weighting method and geographical coordinate were used to estimate the missing data. However, these imputation methods ignored the seasonality in rainfall dataset which could give more reliable estimation. Thus this study is aimed to estimate the missingness in daily rainfall data by using generalized linear model with gamma and Fourier series as the link function and smoothing technique, respectively. Forty years daily rainfall data for the period from 1975 until 2014 which consists of seven stations at Kelantan region were selected for the analysis. The findings indicated that the imputation methods could provide more accurate estimation values based on the least mean absolute error, root mean squared error and coefficient of variation root mean squared error when seasonality in the dataset are considered.
McKeown, Gary J; Sneddon, Ian
2014-03-01
Emotion research has long been dominated by the "standard method" of displaying posed or acted static images of facial expressions of emotion. While this method has been useful, it is unable to investigate the dynamic nature of emotion expression. Although continuous self-report traces have enabled the measurement of dynamic expressions of emotion, a consensus has not been reached on the correct statistical techniques that permit inferences to be made with such measures. We propose generalized additive models and generalized additive mixed models as techniques that can account for the dynamic nature of such continuous measures. These models allow us to hold constant shared components of responses that are due to perceived emotion across time, while enabling inference concerning linear differences between groups. The generalized additive mixed model approach is preferred, as it can account for autocorrelation in time series data and allows emotion decoding participants to be modeled as random effects. To increase confidence in linear differences, we assess the methods that address interactions between categorical variables and dynamic changes over time. In addition, we provide comments on the use of generalized additive models to assess the effect size of shared perceived emotion and discuss sample sizes. Finally, we address additional uses, the inference of feature detection, continuous variable interactions, and measurement of ambiguity.
Goldfarb-Rumyantzev, Alexander; Gautam, Shiva; Brown, Robert S
2016-04-01
This study proposed to validate a prediction model and risk-stratification tool of 2-year mortality rates of individuals in the general population suitable for office practice use. A risk indicator (R) derived from data in the literature was based on only 6 variables: to calculate R for an individual, starting with 0, for each year of age above 60, add 0.14; for a male, add 0.9; for diabetes mellitus, add 0.7; for albuminuria > 30 mg/g of creatinine, add 0.7; for stage ≥ 3 chronic kidney disease (CKD), add 0.9; for cardiovascular disease (CVD), add 1.4; or for both CKD and CVD, add 1.7. We developed a univariate logistic regression model predicting 2-year individual mortality rates. The National Health and Nutrition Examination Survey (NHANES) data set (1999-2004 with deaths through 2006) was used as the target for validation. These 12,515 subjects had a mean age of 48.9 ± 18.1 years, 48% males, 9.5% diabetes, 11.7% albuminuria, 6.8% CVD, 5.4% CKD, and 2.8% both CKD and CVD. Using the risk indicator R alone to predict mortality demonstrated good performance with area under the receiver operating characteristic (ROC) curve of 0.84. Dividing subjects into low-risk (R=0-1.0), low intermediate risk (R > 1.0-3.0), high intermediate risk (R > 3.0-5.0) or high-risk (R > 5.0) categories predicted 2-year mortality rates of 0.52%, 1.44%, 5.19% and 15.24%, respectively, by the prediction model compared with actual mortality rates of 0.29%, 2.48%, 5.13% and 13.40%, respectively. We have validated a model of risk stratification using easily identified clinical characteristics to predict 2-year mortality rates of individuals in the general population. The model demonstrated performance adequate for its potential use for clinical practice and research decisions.
Bayesian model choice and information criteria in sparse generalized linear models
Foygel, Rina
2011-01-01
We consider Bayesian model selection in generalized linear models that are high-dimensional, with the number of covariates p being large relative to the sample size n, but sparse in that the number of active covariates is small compared to p. Treating the covariates as random and adopting an asymptotic scenario in which p increases with n, we show that Bayesian model selection using certain priors on the set of models is asymptotically equivalent to selecting a model using an extended Bayesian information criterion. Moreover, we prove that the smallest true model is selected by either of these methods with probability tending to one. Having addressed random covariates, we are also able to give a consistency result for pseudo-likelihood approaches to high-dimensional sparse graphical modeling. Experiments on real data demonstrate good performance of the extended Bayesian information criterion for regression and for graphical models.
DEFF Research Database (Denmark)
Rosthøj, Susanne; Keiding, Niels
2004-01-01
When studying a regression model measures of explained variation are used to assess the degree to which the covariates determine the outcome of interest. Measures of predictive accuracy are used to assess the accuracy of the predictions based on the covariates and the regression model. We give...... a detailed and general introduction to the two measures and the estimation procedures. The framework we set up allows for a study of the effect of misspecification on the quantities estimated. We also introduce a generalization to survival analysis....
Directory of Open Access Journals (Sweden)
Jacques Auger
2014-02-01
Full Text Available In the present review, we first summarize the main benefits, limitations and pitfalls of conventional in vivo approaches to assessing male reproductive structures and functions in rodents in cases of endocrine active substance (EAS exposure from the postulate that they may provide data that can be extrapolated to humans. Then, we briefly present some integrated approaches in rodents we have recently developed at the organism level. We particularly focus on the possible effects and modes of action (MOA of these substances at low doses and in mixtures, real-life conditions and at the organ level, deciphering the precise effects and MOA on the fetal testis. It can be considered that the in vivo experimental EAS exposure of rodents remains the first choice for studies and is a necessary tool (together with the epidemiological approach for understanding the reproductive effects and MOA of EASs, provided the pitfalls and limitations of the rodent models are known and considered. We also provide some evidence that classical rodent models may be refined for studying the multiple consequences of EAS exposure, not only on the reproductive axis but also on various hormonally regulated organs and tissues, among which several are implicated in the complex process of mammalian reproduction. Such models constitute an interesting way of approaching human exposure conditions. Finally, we show that organotypic culture models are powerful complementary tools, especially when focusing on the MOA. All these approaches have contributed in a combinatorial manner to a better understanding of the impact of EAS exposure on human reproduction.
Biosorption of Ni(II) by Fig Male: Optimization and Modeling Using a Full Factorial Design.
Madjene, F; Chergui, A; Trari, M
2016-06-01
The fig male (FM) is successfully used as biosorbent for Ni(2+) removal. The maximum removal efficiency (96.6%) is obtained at pH ~ 5 for a concentration of 1.70 mmol L(-1) and catalyst dose of 5 g L(-1) in less than 10 minutes. The Ni(2+) uptake follows a pseudo-second-order kinetic, the rate constants increase with increasing temperature, and an activation energy of 55.48 kJ mol(-1) is found. The thermodynamic parameters indicate a spontaneous endothermic bisorption. The isotherm data are fitted by the Langmuir and Dubinin-Radushkevich models. The former indicates a maximum Ni(2+) uptake of 0.459 mmol g(-1), which is higher than that of most biosorbents investigated to date. The FTIR spectra reveal the biosorption mechanism between Ni(2+) and FM functional groups. An empirical modeling is performed by using a 2(3) full factorial design, and a regression equation for Ni(2+) biosorption is determined. The biosorbent mass and pH are the most significant parameters affecting the Ni(2+) biosorption.
Triton College and General Motors: The Partnership Model.
Fonte, Richard; Magnesen, Vernon
1983-01-01
The cooperative training program between Illinois's Triton College and General Motors is described. Illustrates the mutual benefits of this problem and recommends that other colleges follow suit. (NJ)
Generalized linear mixed models modern concepts, methods and applications
Stroup, Walter W
2012-01-01
PART I The Big PictureModeling BasicsWhat Is a Model?Two Model Forms: Model Equation and Probability DistributionTypes of Model EffectsWriting Models in Matrix FormSummary: Essential Elements for a Complete Statement of the ModelDesign MattersIntroductory Ideas for Translating Design and Objectives into ModelsDescribing ""Data Architecture"" to Facilitate Model SpecificationFrom Plot Plan to Linear PredictorDistribution MattersMore Complex Example: Multiple Factors with Different Units of ReplicationSetting the StageGoals for Inference with Models: OverviewBasic Tools of InferenceIssue I: Data
Directory of Open Access Journals (Sweden)
A. El-Shafie
2011-03-01
Full Text Available Artificial neural networks (ANN have been found efficient, particularly in problems where characteristics of the processes are stochastic and difficult to describe using explicit mathematical models. However, time series prediction based on ANN algorithms is fundamentally difficult and faces problems. One of the major shortcomings is the search for the optimal input pattern in order to enhance the forecasting capabilities for the output. The second challenge is the over-fitting problem during the training procedure and this occurs when ANN loses its generalization. In this research, autocorrelation and cross correlation analyses are suggested as a method for searching the optimal input pattern. On the other hand, two generalized methods namely, Regularized Neural Network (RNN and Ensemble Neural Network (ENN models are developed to overcome the drawbacks of classical ANN models. Using Generalized Neural Network (GNN helped avoid over-fitting of training data which was observed as a limitation of classical ANN models. Real inflow data collected over the last 130 years at Lake Nasser was used to train, test and validate the proposed model. Results show that the proposed GNN model outperforms non-generalized neural network and conventional auto-regressive models and it could provide accurate inflow forecasting.
Halliwell, Emma; Dittmar, Helga; Orsborn, Amber
2007-09-01
This study examines the effects of exposure to the muscular male body ideal on body-focused negative affect among male gym users and non-exercisers. As hypothesized, the impact of media exposure depended on men's exercise status. Non-exercisers (n = 58) reported greater body-focused negative affect after exposure to images of muscular male models than after neutral images (no model controls), whereas gym users (n = 58) showed a tendency for less body-focused negative affect after the model images than after the control images. Furthermore, the extent to which gym users were motivated to increase strength and muscularity moderated these exposure effects; men who reported stronger strength and muscularity exercise motivation reported a greater degree of self-enhancement after exposure to the muscular ideal. The findings are interpreted with respect to likely differences in motives for social comparisons.
Directory of Open Access Journals (Sweden)
Clement Kent
Full Text Available Drosophila Cuticular Hydrocarbons (CH influence courtship behaviour, mating, aggregation, oviposition, and resistance to desiccation. We measured levels of 24 different CH compounds of individual male D. melanogaster hourly under a variety of environmental (LD/DD conditions. Using a model-based analysis of CH variation, we developed an improved normalization method for CH data, and show that CH compounds have reproducible cyclic within-day temporal patterns of expression which differ between LD and DD conditions. Multivariate clustering of expression patterns identified 5 clusters of co-expressed compounds with common chemical characteristics. Turnover rate estimates suggest CH production may be a significant metabolic cost. Male cuticular hydrocarbon expression is a dynamic trait influenced by light and time of day; since abundant hydrocarbons affect male sexual behavior, males may present different pheromonal profiles at different times and under different conditions.
Olvera-Hernández, Sandra; Fernández-Guasti, Alonso
2015-01-01
In this chapter we briefly review the evidence supporting the existence of biological influences on sexual orientation. We focus on basic research studies that have affected the estrogen synthesis during the critical periods of brain sexual differentiation in male rat offspring with the use of aromatase inhibitors, such as 1,4,6-androstatriene-3,17 (ATD) and letrozole. The results after prenatal and/or postnatal treatment with ATD reveal that these animals, when adults, show female sexual responses, such as lordosis or proceptive behaviors, but retain their ability to display male sexual activity with a receptive female. Interestingly, the preference and sexual behavior of these rats vary depending upon the circadian rhythm.Recently, we have established that the treatment with low doses of letrozole during the second half of pregnancy produces male rat offspring, that when adults spend more time in the company of a sexually active male than with a receptive female in a preference test. In addition, they display female sexual behavior when forced to interact with a sexually experienced male and some typical male sexual behavior when faced with a sexually receptive female. Interestingly, these males displayed both sexual behavior patterns spontaneously, i.e., in absence of exogenous steroid hormone treatment. Most of these features correspond with those found in human male homosexuals; however, the "bisexual" behavior shown by the letrozole-treated rats may be related to a particular human population. All these data, taken together, permit to propose letrozole prenatal treatment as a suitable animal model to study human male homosexuality and reinforce the hypothesis that human sexual orientation is underlied by changes in the endocrine milieu during early development.
Comparative model accuracy of a data-fitted generalized Aw-Rascle-Zhang model
Fan, Shimao; Seibold, Benjamin
2013-01-01
The Aw-Rascle-Zhang (ARZ) model can be interpreted as a generalization of the Lighthill-Whitham-Richards (LWR) model, possessing a family of fundamental diagram curves, each of which represents a class of drivers with a different empty road velocity. A weakness of this approach is that different drivers possess vastly different densities at which traffic flow stagnates. This drawback can be overcome by modifying the pressure relation in the ARZ model, leading to the generalized Aw-Rascle-Zhang (GARZ) model. We present an approach to determine the parameter functions of the GARZ model from fundamental diagram measurement data. The predictive accuracy of the resulting data-fitted GARZ model is compared to other traffic models by means of a three-detector test setup, employing two types of data: vehicle trajectory data, and sensor data. This work also considers the extension of the ARZ and the GARZ models to models with a relaxation term, and conducts an investigation of the optimal relaxation time.
Tavasszy, L.; Davydenko, I.; Ruijgrok, K.
2009-01-01
The integration of Spatial Equilibrium models and Freight transport network models is important to produce consistent scenarios for future freight transport demand. At various spatial scales, we see the changes in production, trade, logistics networking and transportation, being driven by mass-indiv
Knowledge Extraction for Discriminating Male and Female in Logical Reasoning from Student Model
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A. E. E. ElAlfi
2009-10-01
Full Text Available The learning process is a process of communication and interaction between the teacher and his students on one side and between the students and each others on the other side. Interaction of the teacher with his students has a great importance in the process of learning and education. The pattern and style of this interaction is determined by the educational situation, trends and concerns, and educational characteristics. Classroom interaction has an importance and a big role in increasing the efficiency of the learning process and raising the achievement levels of students. Students need to learn skills and habits of study, especially at the university level. The effectiveness of learning is affected by several factors that include the prevailing patterns of interactive behavior in the classroom. These patterns are reflected in the activities of teacher and learners during the learning process. The effectiveness of learning is also influenced by the cognitive and non cognitive characteristics of teacher that help him to succeed, the characteristics of learners, teaching subject, and the teaching methods. This paper presents a machine learning algorithm for extracting knowledge from student model. The proposed algorithm utilizes the inherent characteristic of genetic algorithm and neural network for extracting comprehensible rules from the student database. The knowledge is used for discriminating male and female levels in logical reasoning as a part of an expert system course.
Aphrodisiac activity of polyherbal formulation in experimental models on male rats
Directory of Open Access Journals (Sweden)
Himanshu Bhusan Sahoo
2014-01-01
Full Text Available Objective: To investigate the aphrodisiac potential of polyherbal formulations prepared from different parts of Tribulus terrestris, Curculigo orchioides, Allium tuberosum, Cucurbita pepo, Elephant creeper, Mucuna pruriens, and Terminalia catappa in Albino rats in specified ratio as suspension. Materials and Methods: The different concentrations of prepared polyherbal formulations i.e. 150, 300, and 600 mg/kg and sildenafil citrate as standard (5 mg/kg and vehicle (control were administered orally to rats (n = 6 animals per group for 3 weeks. Mating behavior parameters in male rats was monitored in first week and third week week of treatment pairing with receptive females. After termination of drug treatment, the mating performance, hormonal analysis, sperm count, and testes-body weight ratio were also evaluated. Results: The polyherbal formulation showed a significant increase in mating behavior as well as mating performance, serum hormonal levels, sperm count, and testes-body weight ratio with dose-dependent relationship as compared to vehicle control. But the dose of 600 mg/kg of polyherbal formulation assumes closer resemblance of above parameters with the standard used. Conclusion: The results of the study strongly suggest that the polyherbal formulations have a good aphrodisiac activity on rats in the above experimental models, which may be an alternative weapon for various sexual dysfunctions in future.
Directory of Open Access Journals (Sweden)
Indranil Sinha
2017-07-01
Full Text Available Obesity leads to a loss of muscle mass and impaired muscle regeneration. In obese individuals, pathologically elevated levels of prolyl hydroxylase domain enzyme 2 (PHD2 limit skeletal muscle hypoxia-inducible factor-1 alpha and vascular endothelial growth factor (VEGF expression. Loss of local VEGF may further impair skeletal muscle regeneration. We hypothesized that PHD2 inhibition would restore vigorous muscle regeneration in a murine model of obesity. Adult (22-week-old male mice were fed either a high-fat diet (HFD, with 60% of calories derived from fat, or a regular diet (RD, with 10% of calories derived from fat, for 16 weeks. On day 5 following cryoinjury to the tibialis anterior muscle, newly regenerated muscle fiber cross-sectional areas were significantly smaller in mice fed an HFD as compared to RD, indicating an impaired regenerative response. Cryoinjured gastrocnemius muscles of HFD mice also showed elevated PHD2 levels (twofold higher and reduced VEGF levels (twofold lower as compared to RD. Dimethyloxalylglycine, a cell permeable competitive inhibitor of PHD2, restored VEGF levels and significantly improved regenerating myofiber size in cryoinjured mice fed an HFD. We conclude that pathologically increased PHD2 in the obese state drives impairments in muscle regeneration, in part by blunting VEGF production. Inhibition of PHD2 over activity in the obese state normalizes VEGF levels and restores muscle regenerative potential.
Modeling Longitudinal Changes in 5 m Sprinting Performance Among Young Male Tennis Players.
Kramer, Tamara; Valente-Dos-Santos, João; Coelho-E-Silva, Manuel J; Malina, Robert M; Huijgen, Barbara C H; Smith, Joanne; Elferink-Gemser, Marije T; Visscher, Chris
2016-02-01
Year-to-year changes in sprinting in youth tennis players were examined in a mixed-longitudinal study (256 male players, aged 10-15 years: 993 measurements). Height (h), body mass (BM), lower limb explosive strength (LLES), and a 5-m sprint were measured over five years. During that period, players were classified as elite or sub-elite. To account for the repeated measurements within the individual nature of longitudinal data, multilevel random effects regression analyses were used. Sprint performance improved with age at each additional 1 year of age, thus predicting ∼.016 sec improvement in five-meter sprint time by all variables of the model. It was possible to predict the performance of elite tennis players in the 5-m sprint (sec) for elite players (1.1493 - (0.0159 ċ centered age) - (0.009 ċ BM) - (0.044 ċ LLES) and sub-elite players (1.1493 - (0.0159 ċ centered age) + 0.0135 - (0.009 ċ BM) - (0.044 ċ LLES) - (0.0557 ċ centered age). Sprint performance differences between elite and sub-elite players was related to longitudinal changes in body size and lower limb strength up until age 13.
Generalized model for predicting methane conversion to syngas in ...
African Journals Online (AJOL)
University School of Chemical Technology, Guru Gobind Singh Indraprastha University ... Linear regression analysis was performed and a generalized equation ... ceramic membrane reactors since it achieves 90% saturation in 25 hours while ...
Hydraulic fracturing model based on the discrete fracture model and the generalized J integral
Liu, Z. Q.; Liu, Z. F.; Wang, X. H.; Zeng, B.
2016-08-01
The hydraulic fracturing technique is an effective stimulation for low permeability reservoirs. In fracturing models, one key point is to accurately calculate the flux across the fracture surface and the stress intensity factor. To achieve high precision, the discrete fracture model is recommended to calculate the flux. Using the generalized J integral, the present work obtains an accurate simulation of the stress intensity factor. Based on the above factors, an alternative hydraulic fracturing model is presented. Examples are included to demonstrate the reliability of the proposed model and its ability to model the fracture propagation. Subsequently, the model is used to describe the relationship between the geometry of the fracture and the fracturing equipment parameters. The numerical results indicate that the working pressure and the pump power will significantly influence the fracturing process.
Generalized linear models for categorical and continuous limited dependent variables
Smithson, Michael
2013-01-01
Introduction and OverviewThe Nature of Limited Dependent VariablesOverview of GLMsEstimation Methods and Model EvaluationOrganization of This BookDiscrete VariablesBinary VariablesLogistic RegressionThe Binomial GLMEstimation Methods and IssuesAnalyses in R and StataExercisesNominal Polytomous VariablesMultinomial Logit ModelConditional Logit and Choice ModelsMultinomial Processing Tree ModelsEstimation Methods and Model EvaluationAnalyses in R and StataExercisesOrdinal Categorical VariablesModeling Ordinal Variables: Common Practice versus Best PracticeOrdinal Model AlternativesCumulative Mod
Hyperbolic value addition and general models of animal choice.
Mazur, J E
2001-01-01
Three mathematical models of choice--the contextual-choice model (R. Grace, 1994), delay-reduction theory (N. Squires & E. Fantino, 1971), and a new model called the hyperbolic value-added model--were compared in their ability to predict the results from a wide variety of experiments with animal subjects. When supplied with 2 or 3 free parameters, all 3 models made fairly accurate predictions for a large set of experiments that used concurrent-chain procedures. One advantage of the hyperbolic value-added model is that it is derived from a simpler model that makes accurate predictions for many experiments using discrete-trial adjusting-delay procedures. Some results favor the hyperbolic value-added model and delay-reduction theory over the contextual-choice model, but more data are needed from choice situations for which the models make distinctly different predictions.
Male tolerance and male-male bonds in a multilevel primate society.
Patzelt, Annika; Kopp, Gisela H; Ndao, Ibrahima; Kalbitzer, Urs; Zinner, Dietmar; Fischer, Julia
2014-10-14
Male relationships in most species of mammals generally are characterized by intense intrasexual competition, with little bonding among unrelated individuals. In contrast, human societies are characterized by high levels of cooperation and strong bonds among both related and unrelated males. The emergence of cooperative male-male relationships has been linked to the multilevel structure of traditional human societies. Based on an analysis of the patterns of spatial and social interaction in combination with genetic relatedness data of wild Guinea baboons (Papio papio), we show that this species exhibits a multilevel social organization in which males maintain strong bonds and are highly tolerant of each other. Several "units" of males with their associated females form "parties," which team up as "gangs." Several gangs of the same "community" use the same home range. Males formed strong bonds predominantly within parties; however, these bonds were not correlated with genetic relatedness. Agonistic interactions were relatively rare and were restricted to a few dyads. Although the social organization of Guinea baboons resembles that of hamadryas baboons, we found stronger male-male affiliation and more elaborate greeting rituals among male Guinea baboons and less aggression toward females. Thus, the social relationships of male Guinea baboons differ markedly from those of other members of the genus, adding valuable comparative data to test hypotheses regarding social evolution. We suggest that this species constitutes an intriguing model to study the predictors and fitness benefits of male bonds, thus contributing to a better understanding of the evolution of this important facet of human social behavior.
A Generalized Nonlocal Calculus with Application to the Peridynamics Model for Solid Mechanics
Alali, Bacim; Liu, Kuo; Gunzburger, Max
2014-01-01
A nonlocal vector calculus was introduced in [2] that has proved useful for the analysis of the peridynamics model of nonlocal mechanics and nonlocal diffusion models. A generalization is developed that provides a more general setting for the nonlocal vector calculus that is independent of particular nonlocal models. It is shown that general nonlocal calculus operators are integral operators with specific integral kernels. General nonlocal calculus properties are developed, including nonlocal...
Estrada-Reyes, R.; Ferreyra-Cruz, O. A.
2016-01-01
Chrysactinia mexicana A. Gray (Asteraceae) and Turnera diffusa Willd (Turneraceae) are employed in traditional medicine as aphrodisiacs; however, there is no scientific evidence supporting the prosexual properties of C. mexicana. The aim of this study was to determine whether an aqueous extract of C. mexicana (Cm) stimulates rat male sexual behavior in the sexual exhaustion paradigm. Sexually exhausted (SExh) male rats were treated with Cm (80, 160, and 320 mg/kg), an aqueous extract of T. diffusa (Td), or yohimbine. The sexual exhaustion state in the control group was characterized by a low percentage of males exhibiting mounts, intromissions, and ejaculations and no males demonstrating mating behavior after ejaculation. Cm (320 mg/kg), Td, or yohimbine significantly increased the proportion of SExh rats that ejaculated and resumed copulation after ejaculation. In males that exhibited reversal of sexual exhaustion, Cm (320 mg/kg) improved sexual performance by reducing the number of intromissions and shrinking ejaculation latency. The effects of treatments on sexual behavior were not related with alterations in general locomotion. In conclusion, the prosexual effects of Cm, as well as those of Td, are established at a central level, which supports the traditional use of C. mexicana for stimulating sexual activity. PMID:27656650
Directory of Open Access Journals (Sweden)
R. Estrada-Reyes
2016-01-01
Full Text Available Chrysactinia mexicana A. Gray (Asteraceae and Turnera diffusa Willd (Turneraceae are employed in traditional medicine as aphrodisiacs; however, there is no scientific evidence supporting the prosexual properties of C. mexicana. The aim of this study was to determine whether an aqueous extract of C. mexicana (Cm stimulates rat male sexual behavior in the sexual exhaustion paradigm. Sexually exhausted (SExh male rats were treated with Cm (80, 160, and 320 mg/kg, an aqueous extract of T. diffusa (Td, or yohimbine. The sexual exhaustion state in the control group was characterized by a low percentage of males exhibiting mounts, intromissions, and ejaculations and no males demonstrating mating behavior after ejaculation. Cm (320 mg/kg, Td, or yohimbine significantly increased the proportion of SExh rats that ejaculated and resumed copulation after ejaculation. In males that exhibited reversal of sexual exhaustion, Cm (320 mg/kg improved sexual performance by reducing the number of intromissions and shrinking ejaculation latency. The effects of treatments on sexual behavior were not related with alterations in general locomotion. In conclusion, the prosexual effects of Cm, as well as those of Td, are established at a central level, which supports the traditional use of C. mexicana for stimulating sexual activity.
Hierarchical Shrinkage Priors and Model Fitting for High-dimensional Generalized Linear Models
Yi, Nengjun; Ma, Shuangge
2013-01-01
Genetic and other scientific studies routinely generate very many predictor variables, which can be naturally grouped, with predictors in the same groups being highly correlated. It is desirable to incorporate the hierarchical structure of the predictor variables into generalized linear models for simultaneous variable selection and coefficient estimation. We propose two prior distributions: hierarchical Cauchy and double-exponential distributions, on coefficients in generalized linear models. The hierarchical priors include both variable-specific and group-specific tuning parameters, thereby not only adopting different shrinkage for different coefficients and different groups but also providing a way to pool the information within groups. We fit generalized linear models with the proposed hierarchical priors by incorporating flexible expectation-maximization (EM) algorithms into the standard iteratively weighted least squares as implemented in the general statistical package R. The methods are illustrated with data from an experiment to identify genetic polymorphisms for survival of mice following infection with Listeria monocytogenes. The performance of the proposed procedures is further assessed via simulation studies. The methods are implemented in a freely available R package BhGLM (http://www.ssg.uab.edu/bhglm/). PMID:23192052
Interest Rates with Long Memory: A Generalized Affine Term-Structure Model
DEFF Research Database (Denmark)
Osterrieder, Daniela
We propose a model for the term structure of interest rates that is a generalization of the discrete-time, Gaussian, affine yield-curve model. Compared to standard affine models, our model allows for general linear dynamics in the vector of state variables. In an application to real yields of U...
Retrofitting Non-Cognitive-Diagnostic Reading Assessment under the Generalized DINA Model Framework
Chen, Huilin; Chen, Jinsong
2016-01-01
Cognitive diagnosis models (CDMs) are psychometric models developed mainly to assess examinees' specific strengths and weaknesses in a set of skills or attributes within a domain. By adopting the Generalized-DINA model framework, the recently developed general modeling framework, we attempted to retrofit the PISA reading assessments, a…
Beyond Information Seeking: Towards a General Model of Information Behaviour
Godbold, Natalya
2006-01-01
Introduction: The aim of the paper is to propose new models of information behaviour that extend the concept beyond simply information seeking to consider other modes of behaviour. The models chiefly explored are those of Wilson and Dervin. Argument: A shortcoming of some models of information behaviour is that they present a sequence of stages…
Model Checking for a General Linear Model with Nonignorable Missing Covariates
Institute of Scientific and Technical Information of China (English)
Zhi-hua SUN; Wai-Cheung IP; Heung WONG
2012-01-01
In this paper,we investigate the model checking problem for a general linear model with nonignorable missing covariates.We show that,without any parametric model assumption for the response probability,the least squares method yields consistent estimators for the linear model even if only the complete data are applied.This makes it feasible to propose two testing procedures for the corresponding model checking problem:a score type lack-of-fit test and a test based on the empirical process.The asymptotic properties of the test statistics are investigated.Both tests are shown to have asymptotic power 1 for local alternatives converging to the null at the rate n-(r),0 ≤ (r) ＜ 1/2.Simulation results show that both tests perform satisfactorily.
Bouaziz, Laurène; de Boer-Euser, Tanja; Brauer, Claudia; Drogue, Gilles; Fenicia, Fabrizio; Grelier, Benjamin; de Niel, Jan; Nossent, Jiri; Pereira, Fernando; Savenije, Hubert; Thirel, Guillaume; Willems, Patrick
2016-04-01
International collaboration between institutes and universities is a promising way to reach consensus on hydrological model development. Education, experience and expert knowledge of the hydrological community have resulted in the development of a great variety of model concepts, calibration methods and analysis techniques. Although comparison studies are very valuable for international cooperation, they do often not lead to very clear new insights regarding the relevance of the modelled processes. We hypothesise that this is partly caused by model complexity and the used comparison methods, which focus on a good overall performance instead of focusing on specific events. We propose an approach that focuses on the evaluation of specific events. Eight international research groups calibrated their model for the Ourthe catchment in Belgium (1607 km2) and carried out a validation in time for the Ourthe (i.e. on two different periods, one of them on a blind mode for the modellers) and a validation in space for nested and neighbouring catchments of the Meuse in a completely blind mode. For each model, the same protocol was followed and an ensemble of best performing parameter sets was selected. Signatures were first used to assess model performances in the different catchments during validation. Comparison of the models was then followed by evaluation of selected events, which include: low flows, high flows and the transition from low to high flows. While the models show rather similar performances based on general metrics (i.e. Nash-Sutcliffe Efficiency), clear differences can be observed for specific events. While most models are able to simulate high flows well, large differences are observed during low flows and in the ability to capture the first peaks after drier months. The transferability of model parameters to neighbouring and nested catchments is assessed as an additional measure in the model evaluation. This suggested approach helps to select, among competing
Generalized isothermal models with strange equation of state
Indian Academy of Sciences (India)
S D Maharaj; S Thirukkanesh
2009-03-01
We consider the linear equation of state for matter distributions that may be applied to strange stars with quark matter. In our general approach the compact relativistic body allows for anisotropic pressures in the presence of the electromagnetic field. New exact solutions are found to the Einstein–Maxwell system. A particular case is shown to be regular at the stellar centre. In the isotropic limit we regain the general relativistic isothermal Universe. We show that the mass corresponds to the values obtained previously for quark stars when anisotropy and charge are present.
A generalized SHGI integrable hierarchy and its expanding integrable model
Institute of Scientific and Technical Information of China (English)
Zhang Yu-Feng
2004-01-01
An anti-symmetric loop algebra A2 is constructed. It follows that an integrable system is obtained by use of Tu's scheme. The eminent feature of this integrable system is that it is reduced to a generalized Schrodinger equation, the well-known heat-conduction equation and a Gerdjkov-Ivanov (GI) equation. Therefore, we call it a generalized SHGI hierarchy. Next, a new high-dimensional subalgebra G of the loop algebra A2 is constructed. As its application, a new expanding integrable system with six potential functions is engendered.
Generalized Heteroskedasticity ACF for Moving Average Models in Explicit Forms
Samir Khaled Safi
2014-01-01
The autocorrelation function (ACF) measures the correlation between observations at different distances apart. We derive explicit equations for generalized heteroskedasticity ACF for moving average of order q, MA(q). We consider two cases: Firstly: when the disturbance term follow the general covariance matrix structure Cov(wi, wj)=S with si,j ¹ 0 " i¹j . Secondly: when the diagonal elements of S are not all identical but sij = 0 " i¹j, i.e. S=diag(s11, s22,&hellip...
Instituto Nacional para la Educacion de los Adultos, Mexico City (Mexico).
This document describes literacy models for urban and rural populations in Mexico. It contains four sections. The first two sections (generalizations about the population and considerations about the teaching of adults) discuss the environment that creates illiterate adults and also describe some of the conditions under which learning takes place…
All-male discussion forums for expectant fathers: evaluation of a model.
Friedewald, Mark; Fletcher, Richard; Fairbairn, Hedy
2005-01-01
This paper describes an all-male discussion forum for expectant fathers led by a male facilitator. The 617 participants completed an evaluation form and were unanimous in their agreement about the benefits of the forum, in particular the opportunity to discuss issues of importance to them with others in a similar situation. The results should encourage those developing antenatal education programs to be more inclusive of expectant fathers and to acknowledge their feelings, unique role, and contribution.
Directory of Open Access Journals (Sweden)
Emmanuel Njeuhmeli
2011-11-01
Full Text Available BACKGROUND: There is strong evidence showing that voluntary medical male circumcision (VMMC reduces HIV incidence in men. To inform the VMMC policies and goals of 13 priority countries in eastern and southern Africa, we estimate the impact and cost of scaling up adult VMMC using updated, country-specific data. METHODS AND FINDINGS: We use the Decision Makers' Program Planning Tool (DMPPT to model the impact and cost of scaling up adult VMMC in Botswana, Lesotho, Malawi, Mozambique, Namibia, Rwanda, South Africa, Swaziland, Tanzania, Uganda, Zambia, Zimbabwe, and Nyanza Province in Kenya. We use epidemiologic and demographic data from recent household surveys for each country. The cost of VMMC ranges from US$65.85 to US$95.15 per VMMC performed, based on a cost assessment of VMMC services aligned with the World Health Organization's considerations of models for optimizing volume and efficiencies. Results from the DMPPT models suggest that scaling up adult VMMC to reach 80% coverage in the 13 countries by 2015 would entail performing 20.34 million circumcisions between 2011 and 2015 and an additional 8.42 million between 2016 and 2025 (to maintain the 80% coverage. Such a scale-up would result in averting 3.36 million new HIV infections through 2025. In addition, while the model shows that this scale-up would cost a total of US$2 billion between 2011 and 2025, it would result in net savings (due to averted treatment and care costs amounting to US$16.51 billion. CONCLUSIONS: This study suggests that rapid scale-up of VMMC in eastern and southern Africa is warranted based on the likely impact on the region's HIV epidemics and net savings. Scaling up of safe VMMC in eastern and southern Africa will lead to a substantial reduction in HIV infections in the countries and lower health system costs through averted HIV care costs.
Generalized anisotropic strange star models for compact stars
Mauryaa, S K; Dayanandan, Baiju; Jasim, M K; Al-Jamel, Ahmed
2015-01-01
We present new anisotropic generalization of Buchdahl [1] type perfect fluid solution by using the method of earlier work [2]. In similar approach we have constructed the new pressure anisotropy factor {\\Delta} by the help both the metric potential e^{\\lambda} and e^{\
Energy Technology Data Exchange (ETDEWEB)
Oren, T.I.
1982-01-01
Simulation is viewed within the model management paradigm. Major components of simulation systems as well as elements of model management are outlined. Possible synergies of simulation model management, software engineering, artificial intelligence, and general system theories are systematized. 21 references.
Institute of Scientific and Technical Information of China (English)
郑晔; 丁训诚; BondeJensPeter; ErnstErik; MortensenJensTolbol; EgenseJohan
1997-01-01
It has been hypothesized that during the last several decades human sperm count has declined because of prenatal exposure to environmental chemicals. We examined the relation between semen.quality and birth year among 8608 men born from 1922 to 1971 and who from 1968 to t992 consulted 4 Danish medical centers because of barren marriage, Data were obtained from medical records and by a postal questionnaire to a subset of the population. The sperm concentration was significantly declining with increasing year of birth in 2 of the 4 centers, but this association disappeared when confounders were adjusted for. Within the subset of men born during 1955--1970 comprising 36% of the entire poputatlon we revealed a decrease of the average sperm concentration by 1.6 millionlml (95% CI: 0.7-2.5) per one advancing year of birth. This finding was consistent across all the 4 centers and robust to adjustment for effects of calendar period, season and duration of sexual abstinence. Effects of age were accounted for by restriction of the sample to men between 20 and 45 years. The findings are compatible with environmental impact in the prenatal period after 1955 but are far from unequivocal evidence that the sperm count in the general male Danish population has changed during the past decades.
Directory of Open Access Journals (Sweden)
Boustead Gregory
2002-04-01
Full Text Available Abstract Introduction Sildenafil (Viagra® is one of the drugs used in the first line therapy of male erectile dysfunction (MED. We have recorded outcomes, adverse events and acceptability of Sildenafil (Viagra therapy in an unselected group of men presenting with ED to a British district general hospital. Methods In this prospective observational study, 147 men with ED were seen since Oct 1999. Study patients were reviewed at 4, 12 and 52 weeks. All the patients filled the International Index of Erectile Function (IIEF questionnaire and were asked about their willingness to pay (WTP for treatment. Results All suitable men accepted Viagra as first line therapy. 91% of our patients found sildenafil treatment successful. 80% of these patients were willing to continue with sildenafil therapy. Side effect profile of sildenafil was different in this study with much higher incidence of headache, dyspepsia, flushing and abnormal vision. 92% of men with ED expect to be treated by the NHS. Of those men eligible for treatment in the NHS, 30% qualify under the clinical categories and 18% under the 'distress' category. Only 55% of those with cardiovascular risk factors qualify for NHS treatment. Conclusions Sildenafil is widely accepted as first line therapy among British men with ED and has a success rate of 91%. Nearly half of men with ED qualify for NHS treatment. Nearly half of those with vascular risk factors do not qualify for NHS treatment. Most men with ED could possibly be managed in primary care.
General model and control of an n rotor helicopter
Sidea, A. G.; Yding Brogaard, R.; Andersen, N. A.; Ravn, O.
2014-12-01
The purpose of this study was to create a dynamic, nonlinear mathematical model of a multirotor that would be valid for different numbers of rotors. Furthermore, a set of Single Input Single Output (SISO) controllers were implemented for attitude control. Both model and controllers were tested experimentally on a quadcopter. Using the combined model and controllers, simple system simulation and control is possible, by replacing the physical values for the individual systems.
General model and control of an n rotor helicopter
2015-01-01
The purpose of this study was to create a dynamic, nonlinear mathematical model ofa multirotor that would be valid for different numbers of rotors. Furthermore, a set of SingleInput Single Output (SISO) controllers were implemented for attitude control. Both model andcontrollers were tested experimentally on a quadcopter. Using the combined model andcontrollers, simple system simulation and control is possible, by replacing the physical valuesfor the individual systems.
General developmental health in the VPA-rat model of autism
Directory of Open Access Journals (Sweden)
Monica Regina Favre
2013-07-01
Full Text Available Autism is a neurodevelopmental condition diagnosed by impaired social interaction, abnormal communication and, stereotyped behaviors. While post-mortem and imaging studies have provided good insights into the neurobiological symptomology of autism, animal models can be used to study the neuroanatomical, neurophysiological and molecular mediators in more detail and in a more controlled environment. The valproic acid (VPA rat model is an environmentally triggered model with strong construct and clinical validity. It is based on VPA teratogenicity in humans, where mothers who are medicated with VPA during early pregnancy show an increased risk for giving birth to an autistic child. In rats, early embryonic exposure, around the time of neural tube closure, leads to autism-like anatomical and behavioral abnormalities in the offspring. Considering the increasing use of the VPA rat model, we present our observations of the general health of Wistar dams treated with a single intraperitoneal injection of 500 or, 600 mg/kg VPA on embryonic day E12.5, as well as their male and female offspring, in comparison to saline-exposed controls. We report increased rates of complete fetal reabsorption after both VPA doses. VPA 500 mg/kg showed no effect on dam body weight during pregnancy or, on litter size. Offspring exposed to VPA 500 mg/kg showed smaller brain mass on postnatal days 1 (P1 and 14 (P14, in addition to abnormal nest seeking behavior at P10 in the olfactory discrimination test, relative to controls. We also report increased rates of physical malformations in the offspring, rare occurrences of chromodacryorrhea and, developmentally similar body mass gain. Further documentation of developmental health may guide sub-grouping of individuals in a way to better predict core symptom severity.