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Sample records for models lexing xie

  1. LexRDF Model: An RDF-based Unified Model for Heterogeneous Biomedical Ontologies.

    Science.gov (United States)

    Tao, Cui; Pathak, Jyotishman; Solbrig, Harold R; Wei, Wei-Qi; Chute, Christopher G

    2009-10-26

    The Lexical Grid (LexGrid) project is an on-going community-driven initiative coordinated by the Mayo Clinic Division of Biomedical Statistics and Informatics (BSI). It provides a common terminology model to represent multiple vocabulary and ontology sources as well as a scalable and robust API for accessing such information. While successfully used and adopted in the biomedical and clinical community, an important requirement is to align the existing LexGrid model with emerging Semantic Web standards and specifications. This paper introduces the LexRDF model, which maps the LexGrid model elements to corresponding constructs in W3C specifications such as RDF, OWL, and SKOS. Our mapping specification successfully used W3C standards to represent most of the existing LexGrid components, and those that did not map point out issues in the existing specifications that the W3C may want to consider in future work. With LexRDF, the terminological information represented in LexGrid can be translated to RDF triples, and therefore allowing LexGrid to leverage standard tools and technologies such as SPARQL and RDF triple stores.

  2. LexRDF Model: An RDF-based Unified Model for Heterogeneous Biomedical Ontologies⋆

    Science.gov (United States)

    Tao, Cui; Pathak, Jyotishman; Solbrig, Harold R.; Wei, Wei-Qi; Chute, Christopher G.

    2011-01-01

    The Lexical Grid (LexGrid) project is an on-going community-driven initiative coordinated by the Mayo Clinic Division of Biomedical Statistics and Informatics (BSI). It provides a common terminology model to represent multiple vocabulary and ontology sources as well as a scalable and robust API for accessing such information. While successfully used and adopted in the biomedical and clinical community, an important requirement is to align the existing LexGrid model with emerging Semantic Web standards and specifications. This paper introduces the LexRDF model, which maps the LexGrid model elements to corresponding constructs in W3C specifications such as RDF, OWL, and SKOS. Our mapping specification successfully used W3C standards to represent most of the existing LexGrid components, and those that did not map point out issues in the existing specifications that the W3C may want to consider in future work. With LexRDF, the terminological information represented in LexGrid can be translated to RDF triples, and therefore allowing LexGrid to leverage standard tools and technologies such as SPARQL and RDF triple stores. PMID:21804785

  3. LEX Project

    DEFF Research Database (Denmark)

    Damkilde, Lars; Larsen, Torben J.; Walbjørn, Jacob

    This document is aimed at helping all parties involved in the LEX project to get a common understanding of words, process, levels and the overall concept.......This document is aimed at helping all parties involved in the LEX project to get a common understanding of words, process, levels and the overall concept....

  4. DisLexList

    DEFF Research Database (Denmark)

    2013-01-01

    DisLexList is a simple analysis script for the generation of lists of lexemes in discourses, and may be used as a tool in discourse analysis (critical and otherwise). DisLexList is, in its current state, able to generate simple word lists and lexeme list based on output from VISL's flat structure...

  5. De la Lex Mercatoria a la Lex Construccionis.

    Directory of Open Access Journals (Sweden)

    Camilo Franco Leguízamo

    2007-06-01

    Full Text Available Lex mercatoria, o bien, el conjunto de reglas aplicables a los contratos internacionales es el tema sobre el que se ocupa el presente artículo, en el cual se pretende una visión general sobre la misma, y un acercamiento a su especialización en los diferentes sectores de la economía internacional. Éste estudio general abarca las principales vicisitudes acerca de la lex mercatoria, su recepción en el ordenamiento Colombiano, así como también, el alcance de su contenido en los sectores informático, petrolero, y de la construcción.

  6. De la Lex Mercatoria a la Lex Construccionis.

    Directory of Open Access Journals (Sweden)

    Camilo Franco Leguízamo

    2007-01-01

    Full Text Available Lex mercatoria, o bien, el conjunto de reglas aplicables a los contratos internacionales es el tema sobre el que se ocupa el presente artículo, en el cual se pretende una visión general sobre la misma, y un acercamiento a su especialización en los diferentes sectores de la economía internacional. Éste estudio general abarca las principales vicisitudes acerca de la lex mercatoria, su recepción en el ordenamiento Colombiano, así como también, el alcance de su contenido en los sectores informático, petrolero, y de la construcción.

  7. The Verrucomicrobia LexA-binding Motif: Insights into the Evolutionary Dynamics of the SOS Response

    Directory of Open Access Journals (Sweden)

    Ivan Erill

    2016-07-01

    Full Text Available The SOS response is the primary bacterial mechanism to address DNA damage, coordinating multiple cellular processes that include DNA repair, cell division and translesion synthesis. In contrast to other regulatory systems, the composition of the SOS genetic network and the binding motif of its transcriptional repressor, LexA, have been shown to vary greatly across bacterial clades, making it an ideal system to study the co-evolution of transcription factors and their regulons. Leveraging comparative genomics approaches and prior knowledge on the core SOS regulon, here we define the binding motif of the Verrucomicrobia, a recently described phylum of emerging interest due to its association with eukaryotic hosts. Site directed mutagenesis of the Verrucomicrobium spinosum recA promoter confirms that LexA binds a 14 bp palindromic motif with consensus sequence TGTTC-N4-GAACA. Computational analyses suggest that recognition of this novel motif is determined primarily by changes in base-contacting residues of the third alpha helix of the LexA helix-turn-helix DNA binding motif. In conjunction with comparative genomics analysis of the LexA regulon in the Verrucomicrobia phylum, electrophoretic shift assays reveal that LexA binds to operators in the promoter region of DNA repair genes and a mutagenesis cassette in this organism, and identify previously unreported components of the SOS response. The identification of tandem LexA-binding sites generating instances of other LexA-binding motifs in the lexA gene promoter of Verrucomicrobia species leads us to postulate a novel mechanism for LexA-binding motif evolution. This model, based on gene duplication, successfully addresses outstanding questions in the intricate co-evolution of the LexA protein, its binding motif and the regulatory network it controls.

  8. Hawking Temperature of Acoustic Black Hole Zhi Kun Xie

    Indian Academy of Sciences (India)

    With parameter r = rH(ν), it is the local event horizon of the acoustic black hole. The new tortoise coordinate can be expressed as (Zheng et al. 2010; Zhikun &. Xie 2011; Weizhen et al. 2011) r∗ = 1. 2κ ln. [ r − rH. rH. ] , ν∗ = ν − ν0, θ∗ = θ − θ0, ϕ∗ = ϕ − ϕ0,. (2) where κ is an adjustable parameter, and κ, ν0,θ0 and ϕ0 are all ...

  9. Computational analysis of LexA regulons in Cyanobacteria

    Directory of Open Access Journals (Sweden)

    Su Zhengchang

    2010-09-01

    Full Text Available Abstract Background The transcription factor LexA plays an important role in the SOS response in Escherichia coli and many other bacterial species studied. Although the lexA gene is encoded in almost every bacterial group with a wide range of evolutionary distances, its precise functions in each group/species are largely unknown. More recently, it has been shown that lexA genes in two cyanobacterial genomes Nostoc sp. PCC 7120 and Synechocystis sp. PCC 6803 might have distinct functions other than the regulation of the SOS response. To gain a general understanding of the functions of LexA and its evolution in cyanobacteria, we conducted the current study. Results Our analysis indicates that six of 33 sequenced cyanobacterial genomes do not harbor a lexA gene although they all encode the key SOS response genes, suggesting that LexA is not an indispensable transcription factor in these cyanobacteria, and that their SOS responses might be regulated by different mechanisms. Our phylogenetic analysis suggests that lexA was lost during the course of evolution in these six cyanobacterial genomes. For the 26 cyanobacterial genomes that encode a lexA gene, we have predicted their LexA-binding sites and regulons using an efficient binding site/regulon prediction algorithm that we developed previously. Our results show that LexA in most of these 26 genomes might still function as the transcriptional regulator of the SOS response genes as seen in E. coli and other organisms. Interestingly, putative LexA-binding sites were also found in some genomes for some key genes involved in a variety of other biological processes including photosynthesis, drug resistance, etc., suggesting that there is crosstalk between the SOS response and these biological processes. In particular, LexA in both Synechocystis sp. PCC6803 and Gloeobacter violaceus PCC7421 has largely diverged from those in other cyanobacteria in the sequence level. It is likely that LexA is no longer a

  10. LexGrid: a framework for representing, storing, and querying biomedical terminologies from simple to sublime.

    Science.gov (United States)

    Pathak, Jyotishman; Solbrig, Harold R; Buntrock, James D; Johnson, Thomas M; Chute, Christopher G

    2009-01-01

    Many biomedical terminologies, classifications, and ontological resources such as the NCI Thesaurus (NCIT), International Classification of Diseases (ICD), Systematized Nomenclature of Medicine (SNOMED), Current Procedural Terminology (CPT), and Gene Ontology (GO) have been developed and used to build a variety of IT applications in biology, biomedicine, and health care settings. However, virtually all these resources involve incompatible formats, are based on different modeling languages, and lack appropriate tooling and programming interfaces (APIs) that hinder their wide-scale adoption and usage in a variety of application contexts. The Lexical Grid (LexGrid) project introduced in this paper is an ongoing community-driven initiative, coordinated by the Mayo Clinic Division of Biomedical Statistics and Informatics, designed to bridge this gap using a common terminology model called the LexGrid model. The key aspect of the model is to accommodate multiple vocabulary and ontology distribution formats and support of multiple data stores for federated vocabulary distribution. The model provides a foundation for building consistent and standardized APIs to access multiple vocabularies that support lexical search queries, hierarchy navigation, and a rich set of features such as recursive subsumption (e.g., get all the children of the concept penicillin). Existing LexGrid implementations include the LexBIG API as well as a reference implementation of the HL7 Common Terminology Services (CTS) specification providing programmatic access via Java, Web, and Grid services.

  11. Lex marks the spot: the virulent side of SOS and a closer look at the LexA regulon.

    Science.gov (United States)

    Kelley, William L

    2006-12-01

    The SOS response that responds to DNA damage induces many genes that are under LexA repression. A detailed examination of LexA regulons using genome-wide techniques has recently been undertaken in both Escherichia coli and Bacillus subtilis. These extensive and elegant studies have now charted the extent of the LexA regulons, uncovered many new genes, and exposed a limited overlap in the LexA regulon between the two bacteria. As more bacterial genomes are analysed, more curiosities in LexA regulons arise. Several notable examples include the discovery of a LexA-like protein, HdiR, in Lactococcus lactis, organisms with two lexA genes, and small DNA damage-inducible cassettes under LexA control. In the cyanobacterium Synechocystis, genetic and microarray studies demonstrated that a LexA paralogue exerts control over an entirely different set of carbon-controlled genes and is crucial to cells facing carbon starvation. An examination of SOS induction evoked by common therapeutic drugs has shed new light on unsuspected consequences of drug exposure. Certain antibiotics, most notably fluoroquinolones such as ciprofloxacin, can induce an SOS response and can modulate the spread of virulence factors and drug resistance. SOS induction by beta-lactams in E. coli triggers a novel form of antibiotic defence that involves cell wall stress and signal transduction by the DpiAB two-component system. In this review, we provide an overview of these new directions in SOS and LexA research with emphasis on a few themes: identification of genes under LexA control, the identification of new endogenous triggers, and antibiotic-induced SOS response and its consequences.

  12. Therapeutic effect of He-Wei-Tong-Xie decoction on acute ...

    African Journals Online (AJOL)

    Purpose: To study the therapeutic effect of He-Wei-Tong-Xie (HWXT) decoction on acute pancreatitis. (AP) complicated with gastrointestinal dysfunction. Methods: AP patients (50) were recruited from the Teaching Hospital of Chengdu University of. Traditional Chinese Medicine and randomly divided into treatment and ...

  13. LexGram - a practical categorial grammar formalism -

    OpenAIRE

    Koenig, Esther

    1995-01-01

    We present the LexGram system, an amalgam of (Lambek) categorial grammar and Head Driven Phrase Structure Grammar (HPSG), and show that the grammar formalism it implements is a well-structured and useful tool for actual grammar development.

  14. Seleksi Atribut Menggunakan Information Gain Untuk Clustering Penduduk Miskin Dengan Validity Index Xie Beni

    Directory of Open Access Journals (Sweden)

    Femi Dwi Astuti

    2017-11-01

    Full Text Available Di wilayah Kecamatan Bantul, seorang warga disebut sebagai keluarga miskin berdasarkan beberapa aspek seperti aspek pangan, sandang, papan, penghasilan, kesehatan, pendidikan, kekayaan, air bersih, listrik maupun jumlah jiwa. Aspek-aspek tersebut akan digunakan sebagai atribut dalam proses clustering. Masing-masing atribut memiliki nilai yang akan diolah. Penelitian ini dikerjakan menggunakan seleksi atribut information gain sebelum proses clustering untuk melihat atribut mana yang sebenarnya berpengaruh dan tidak, sehingga hanya atribut yang berpengaruh saja yang akan digunakan, metode Fuzzy C-Means untuk clustering penduduk miskin dan Xie Beni untuk menentukan jumlah klaster terbaik. Hasil penelitian menunjukkan penggunaan information gain dengan threshold 0.0001 untuk clustering dengan menghilangkan atribut penghasilan memiliki hasil cluster yang sama dengan menggunakan atribut penghasilan. Pengujian terhadap 23, 500, 1000 dan 1313 untuk jumlah cluster 2, 3, 4, 5, 6 dan 7 menunjukkan bahwa nilai dari Xie-Beni Index terkecil adalah 5 dengan nilai 0,1343, sehingga cluster yang paling optimal adalah 5.

  15. ASL-LEX: A lexical database of American Sign Language

    Science.gov (United States)

    Caselli, Naomi K.; Sehyr, Zed Sevcikova; Cohen-Goldberg, Ariel M.; Emmorey, Karen

    2016-01-01

    ASL-LEX is a lexical database that catalogues information about nearly 1,000 signs in American Sign Language (ASL). It includes the following information: subjective frequency ratings from 25–31 deaf signers, iconicity ratings from 21–37 hearing non-signers, videoclip duration, sign length (onset and offset), grammatical class, and whether the sign is initialized, a fingerspelled loan sign or a compound. Information about English translations is available for a subset of signs (e.g., alternate translations, translation consistency). In addition, phonological properties (sign type, selected fingers, flexion, major and minor location, and movement) were coded and used to generate sub-lexical frequency and neighborhood density estimates. ASL-LEX is intended for use by researchers, educators, and students who are interested in the properties of the ASL lexicon. An interactive website where the database can be browsed and downloaded is available at http://asl-lex.org. PMID:27193158

  16. ASL-LEX: A lexical database of American Sign Language.

    Science.gov (United States)

    Caselli, Naomi K; Sehyr, Zed Sevcikova; Cohen-Goldberg, Ariel M; Emmorey, Karen

    2017-04-01

    ASL-LEX is a lexical database that catalogues information about nearly 1,000 signs in American Sign Language (ASL). It includes the following information: subjective frequency ratings from 25-31 deaf signers, iconicity ratings from 21-37 hearing non-signers, videoclip duration, sign length (onset and offset), grammatical class, and whether the sign is initialized, a fingerspelled loan sign, or a compound. Information about English translations is available for a subset of signs (e.g., alternate translations, translation consistency). In addition, phonological properties (sign type, selected fingers, flexion, major and minor location, and movement) were coded and used to generate sub-lexical frequency and neighborhood density estimates. ASL-LEX is intended for use by researchers, educators, and students who are interested in the properties of the ASL lexicon. An interactive website where the database can be browsed and downloaded is available at http://asl-lex.org .

  17. MediLex: the medical jargon-busting game.

    Science.gov (United States)

    Smith, Susan; Fisher, James; Goff, Iain

    2017-08-01

    During their training, medical students are expected to acquire the ability to use thousands of new terms that make up the medical lexicon. Clear communication requires knowledge of this lexicon. We developed a simple word game, MediLex, to facilitate the development of these skills. This paper describes the intervention and evaluates students' experiences. MediLex is a card-based description game played in small groups. One hundred cards contain 500 medical terms grouped into five categories. The cardholder is asked to describe the terms on the card while group members have a limited time to deduce the term being described. Students were asked to evaluate MediLex using an electronic survey with free-text responses. Content analysis was undertaken by two independent researchers, and after discussion a consensus on themes was reached. Medical students are expected to acquire the ability to use thousands of new terms that make up the medical lexicon RESULTS: MediLex was used on six different occasions. Sixty-eight students played the game and 61 completed the survey. Fifty-six out of 61 students deemed MediLex to be a valuable learning experience. The analysis of responses revealed five themes: 'highlighted knowledge gaps'; 'revision/reactivation of knowledge'; 'explanation skills'; 'fun/engaging'; and 'fast pace'. Learning new vocabulary is a complex process, yet is a principle contributor to comprehension, fluency and achievement. Research suggests that playing games with content vocabulary allows learners to explore pronunciation and meanings simultaneously. MediLex allows learners to do this, whilst giving the opportunity to hear their peers' comprehension of meaning. Mastering the medical lexicon is a huge challenge because of the breadth and complexity of medical terminology, and focused teaching on this appears to be well received by students. © 2016 John Wiley & Sons Ltd and The Association for the Study of Medical Education.

  18. Xie He composição musical, modulação e ritornelo

    Directory of Open Access Journals (Sweden)

    Silvio Ferraz

    2014-12-01

    Full Text Available Neste breve ensaio procuro apresentar uma poética composicional, tendo por base um cruzamento entre pensamento específico da pintura chinesa e noções da filosofia ocidental que dialogam com tal pensamento. Proponho assim um cruzamento das noções de quatro autores Gilbert Simondon, Gilles Deleuze e Félix Guattari e Xie He: as noções de modulação e ritornelo em contraponto aos seis cânones da pintura clássica chinesa, propostos pelo pintor e calígrafo chinês Xie He, no séc. V. De certo modo retomo a relação entre Xie He e a filosofia da diferença através do que está traçado nos escritos e aulas de Gilles Deleuze. O ponto de articulação entre as diferentes proposições está justamente no conceito de Ritornelo, proposto por Guattari e Deleuze em seu livro Mille Plateaux. e na modulação como motor principal deste conceito (compreendida a partir das proposições de Gilbert Simondon. Ao longo do ensaio apresento os dois primeiros cânones da pintura chinesa, os aproximando passo a passo da noção de modulação para, por fim, apresentar uma leitura do conceito de ritornelo e o modo como tais conceitos, noções e cânones podem se fazer presentes no processo composicional da música atual.

  19. Computational features of the dictionary application “TshwaneLex ...

    African Journals Online (AJOL)

    The aim of this article is to introduce and to elaborate on computational aspects of TshwaneLex, a new South African software application for dictionary compilation. A brief introduction to the lexicographic needs for such a computer program in South Africa will be given, followed by a description of the most salient features of ...

  20. The Effect of Tong-Xie-Yao-Fang on Intestinal Mucosal Mast Cells in Postinfectious Irritable Bowel Syndrome Rats

    Directory of Open Access Journals (Sweden)

    Xiangxue Ma

    2017-01-01

    Full Text Available Objective. To investigate the effects of Tong-Xie-Yao-Fang (TXYF on intestinal mucosal mast cells in rats with postinfectious irritable bowel syndrome (PI-IBS. Design. PI-IBS rat models were established using a multistimulation paradigm. Then, rats were treated with TXYF intragastrically at doses of 2.5, 5.0, and 10.0 g·kg−1·d−1 for 14 days, respectively. Intestinal sensitivity was assessed based on abdominal withdrawal reflex (AWR scores and fecal water content (FWC. Mast cell counts and the immunofluorescence of tryptase and c-Fos in intestinal mucosa were measured; and serum IL-1β, TNF-α, and histamine levels were determined. Results. AWR reactivity and FWC which were significantly increased could be observed in PI-IBS rats. Remarkably increased mast cell activation ratio in intestinal mucosa, together with increased serum TNF-α and histamine levels, could also be seen in PI-IBS rats; furthermore, PI-IBS-induced changes in mast cell activation and level of serum TNF-α and histamine could be reversed by TXYF treatment. Meanwhile, tryptase and c-Fos expression were also downregulated. Conclusion. TXYF improves PI-IBS symptoms by alleviating behavioral hyperalgesia and antidiarrhea, the underlying mechanism of which involves the inhibitory effects of TXYF on activating mucosal mast cells, downregulating tryptase and c-Fos expression, and reducing serum TNF-α and histamine levels.

  1. BioLex. Database for interpretation of characteristics of biofuels and bioashes. Phase 1; BioLex. Database til fortolkning af karakteristika for biobraendsler og -asker. Fase 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-01-01

    BioLex is a danish data base containing information about solid biofuels and bioashes, e.g. chemical analysis. It has been of vital importance to provide background information about the tests behind the figures presented to the BioLex user. The data base is available on the internet in a temporary version. (BA)

  2. Enhanced LexSynonym Acquisition for Effective UMLS Concept Mapping.

    Science.gov (United States)

    Lu, Chris J; Tormey, Destinee; McCreedy, Lynn; Browne, Allen C

    2017-01-01

    Concept mapping is important in natural language processing (NLP) for bioinformatics. The UMLS Metathesaurus provides a rich synonym thesaurus and is a popular resource for concept mapping. Query expansion using synonyms for subterm substitutions is an effective technique to increase recall for UMLS concept mapping. Synonyms used to substitute subterms are called element synonyms. The completeness and quality of both element synonyms and the UMLS synonym thesaurus is the key to success in such applications. The Lexical Systems Group (LSG) has developed a new system for element synonym acquisition based on new enhanced requirements and design for better performance. The results show: 1) A 36.71 times growth of synonyms in the Lexicon (lexSynonym) in the 2017 release; 2) Improvements of concept mapping for recall and F1 with similar precision using the lexSynonym.2017 as element synonyms due to the broader coverage and better quality.

  3. Lex mercatoria in international arbitration theory and practice

    OpenAIRE

    ELCIN, Mert

    2012-01-01

    Defence date: 26 November 2012 Examining Board: Professor Fabrizio Cafaggi (EUI Supervisor) Professor Francesco Francioni (EUI) Professor Sandrine Clavel Université de Versailles-Saint Quentin Professor Fabrizio Marrella Università Cà Foscari di Venezia. First made available online: 2 August 2016 This dissertation suggests a new theory of lex mercatoria that takes into account the complex and spontaneous order of international commerce. Since the emphasis is put on the nature of t...

  4. El papel de la societas mercatorum en la creación normativa: la lex mercatoria

    Directory of Open Access Journals (Sweden)

    Francisco López Ruiz

    2010-06-01

    Se puede considerar como Derecho el conjunto de reglas – la lex mercatoria – elaboradas por asociaciones profesionales internacionales, grandes firmas de abogados y empresas transnacionales?. La tesis que mantendré es que la lex mercatoria  es, ciertamente un conjunto de reglas jurídicas altamente eficaces en el ámbito de los negocios internacionales. Sin embargo, tal eficacia no puede servir como criterio de legitimidad de la lex mercatoria.

  5. Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice.

    Directory of Open Access Journals (Sweden)

    Jeanne Farrell

    Full Text Available BACKGROUND: Mammalian Soluble adenylyl cyclase (sAC, Adcy10, or Sacy represents a source of the second messenger cAMP distinct from the widely studied, G protein-regulated transmembrane adenylyl cyclases. Genetic deletion of the second through fourth coding exons in Sacy(tm1Lex/Sacy(tm1Lex knockout mice results in a male sterile phenotype. The absence of any major somatic phenotype is inconsistent with the variety of somatic functions identified for sAC using pharmacological inhibitors and RNA interference. PRINCIPAL FINDINGS: We now use immunological and molecular biological methods to demonstrate that somatic tissues express a previously unknown isoform of sAC, which utilizes a unique start site, and which 'escapes' the design of the Sacy(tm1Lex knockout allele. CONCLUSIONS/SIGNIFICANCE: These studies reveal increased complexity at the sAC locus, and they suggest that the known isoforms of sAC play a unique function in male germ cells.

  6. Reconstruction of the evolutionary history of the LexA-binding sequence.

    Science.gov (United States)

    Mazón, Gerard; Erill, Ivan; Campoy, Susana; Cortés, Pilar; Forano, Evelyne; Barbé, Jordi

    2004-11-01

    In recent years, the recognition sequence of the SOS repressor LexA protein has been identified for several bacterial clades, such as the Gram-positive, green non-sulfur bacteria and Cyanobacteria phyla, or the 'Alphaproteobacteria', 'Deltaproteobacteria' and 'Gammaproteobacteria' classes. Nevertheless, the evolutionary relationship among these sequences and the proteins that recognize them has not been analysed. Fibrobacter succinogenes is an anaerobic Gram-negative bacterium that branched from a common bacterial ancestor immediately before the Proteobacteria phylum. Taking advantage of its intermediate position in the phylogenetic tree, and in an effort to reconstruct the evolutionary history of LexA-binding sequences, the F. succinogenes lexA gene has been isolated and its product purified to identify its DNA recognition motif through electrophoretic mobility assays and footprinting experiments. After comparing the available LexA DNA-binding sequences with the F. succinogenes one, reported here, directed mutagenesis of the F. succinogenes LexA-binding sequence and phylogenetic analyses of LexA proteins have revealed the existence of two independent evolutionary lanes for the LexA recognition motif that emerged from the Gram-positive box: one generating the Cyanobacteria and 'Alphaproteobacteria' LexA-binding sequences, and the other giving rise to the F. succinogenes and Myxococcus xanthus ones, in a transitional step towards the current 'Gammaproteobacteria' LexA box. The contrast between the results reported here and the phylogenetic data available in the literature suggests that, some time after its emergence as a distinct bacterial class, the 'Alphaproteobacteria' lost its vertically received lexA gene, but received later through lateral gene transfer a new lexA gene belonging to either a cyanobacterium or a bacterial species closely related to this phylum. This constitutes the first report based on experimental evidence of lateral gene transfer in the

  7. NeuroLex.org: an online framework for neuroscience knowledge

    Science.gov (United States)

    Larson, Stephen D.; Martone, Maryann E.

    2013-01-01

    The ability to transmit, organize, and query information digitally has brought with it the challenge of how to best use this power to facilitate scientific inquiry. Today, few information systems are able to provide detailed answers to complex questions about neuroscience that account for multiple spatial scales, and which cross the boundaries of diverse parts of the nervous system such as molecules, cellular parts, cells, circuits, systems and tissues. As a result, investigators still primarily seek answers to their questions in an increasingly densely populated collection of articles in the literature, each of which must be digested individually. If it were easier to search a knowledge base that was structured to answer neuroscience questions, such a system would enable questions to be answered in seconds that would otherwise require hours of literature review. In this article, we describe NeuroLex.org, a wiki-based website and knowledge management system. Its goal is to bring neurobiological knowledge into a framework that allows neuroscientists to review the concepts of neuroscience, with an emphasis on multiscale descriptions of the parts of nervous systems, aggregate their understanding with that of other scientists, link them to data sources and descriptions of important concepts in neuroscience, and expose parts that are still controversial or missing. To date, the site is tracking ~25,000 unique neuroanatomical parts and concepts in neurobiology spanning experimental techniques, behavioral paradigms, anatomical nomenclature, genes, proteins and molecules. Here we show how the structuring of information about these anatomical parts in the nervous system can be reused to answer multiple neuroscience questions, such as displaying all known GABAergic neurons aggregated in NeuroLex or displaying all brain regions that are known within NeuroLex to send axons into the cerebellar cortex. PMID:24009581

  8. NeuroLex.org: An online framework for neuroscience knowledge

    Directory of Open Access Journals (Sweden)

    Stephen D Larson

    2013-08-01

    Full Text Available The ability to transmit, organize, and query information digitally has brought with it the challenge of how to best use this power to facilitate scientific inquiry. Today, few information systems are able to provide detailed answers to complex questions about neuroscience that account for multiple spatial scales, and which cross the boundaries of diverse parts of the nervous system such as molecules, cellular parts, cells, circuits, systems and tissues. As a result, investigators still primarily seek answers to their questions in an increasingly densely populated collection of articles in the literature, each of which must be digested individually. If it were easier to search a knowledge base that was structured to answer neuroscience questions, such a system would enable questions to be answered in seconds that would otherwise require hours of literature review.In this article, we describe NeuroLex.org, a wiki-based website and knowledge management system. Its goal is to bring neurobiological knowledge into a framework that allows neuroscientists to review the concepts of neuroscience, with an emphasis on multiscale descriptions of the parts of nervous systems, aggregate their understanding with that of other scientists, link them to data sources and descriptions of important concepts in neuroscience, and expose parts that are still controversial or missing. To date, the site is tracking ~25,000 unique neuroanatomical parts and concepts in neurobiology spanning experimental techniques, behavioral paradigms, anatomical nomenclature, genes, proteins and molecules. Here we show how the structuring of information about these anatomical parts in the nervous system can be reused to answer multiple neuroscience questions, such as displaying all known GABAergic neurons aggregated in NeuroLex or displaying all brain regions that are known within NeuroLex to send axons into the cerebellar cortex.

  9. A Drosophila LexA Enhancer-Trap Resource for Developmental Biology and Neuroendocrine Research

    Science.gov (United States)

    Kockel, Lutz; Huq, Lutfi M.; Ayyar, Anika; Herold, Emma; MacAlpine, Elle; Logan, Madeline; Savvides, Christina; Kim, Grace E. S.; Chen, Jiapei; Clark, Theresa; Duong, Trang; Fazel-Rezai, Vahid; Havey, Deanna; Han, Samuel; Jagadeesan, Ravi; Kim, Eun Soo Jackie; Lee, Diane; Lombardo, Kaelina; Piyale, Ida; Shi, Hansen; Stahr, Lydia; Tung, Dana; Tayvah, Uriel; Wang, Flora; Wang, Ja-Hon; Xiao, Sarah; Topper, Sydni M.; Park, Sangbin; Rotondo, Cheryl; Rankin, Anne E.; Chisholm, Townley W.; Kim, Seung K.

    2016-01-01

    Novel binary gene expression tools like the LexA-LexAop system could powerfully enhance studies of metabolism, development, and neurobiology in Drosophila. However, specific LexA drivers for neuroendocrine cells and many other developmentally relevant systems remain limited. In a unique high school biology course, we generated a LexA-based enhancer trap collection by transposon mobilization. The initial collection provides a source of novel LexA-based elements that permit targeted gene expression in the corpora cardiaca, cells central for metabolic homeostasis, and other neuroendocrine cell types. The collection further contains specific LexA drivers for stem cells and other enteric cells in the gut, and other developmentally relevant tissue types. We provide detailed analysis of nearly 100 new LexA lines, including molecular mapping of insertions, description of enhancer-driven reporter expression in larval tissues, and adult neuroendocrine cells, comparison with established enhancer trap collections and tissue specific RNAseq. Generation of this open-resource LexA collection facilitates neuroendocrine and developmental biology investigations, and shows how empowering secondary school science can achieve research and educational goals. PMID:27527793

  10. Rail-lex Slovenia--A Modern Railway Dictionary (Joint Venture Case Study).

    Science.gov (United States)

    Jakopin, Primoz

    Rail-lex Slovenia is a project to develop a dictionary of railway terminology in the Slovenian language, part of a larger undertaking of the International Union of Railways to develop a modern, multilingual communication infrastructure. Participating organizations represent 22 European languages. Two partners in the Rail-lex Slovenia venture are…

  11. A Drosophila LexA Enhancer-Trap Resource for Developmental Biology and Neuroendocrine Research

    Directory of Open Access Journals (Sweden)

    Lutz Kockel

    2016-10-01

    Full Text Available Novel binary gene expression tools like the LexA-LexAop system could powerfully enhance studies of metabolism, development, and neurobiology in Drosophila. However, specific LexA drivers for neuroendocrine cells and many other developmentally relevant systems remain limited. In a unique high school biology course, we generated a LexA-based enhancer trap collection by transposon mobilization. The initial collection provides a source of novel LexA-based elements that permit targeted gene expression in the corpora cardiaca, cells central for metabolic homeostasis, and other neuroendocrine cell types. The collection further contains specific LexA drivers for stem cells and other enteric cells in the gut, and other developmentally relevant tissue types. We provide detailed analysis of nearly 100 new LexA lines, including molecular mapping of insertions, description of enhancer-driven reporter expression in larval tissues, and adult neuroendocrine cells, comparison with established enhancer trap collections and tissue specific RNAseq. Generation of this open-resource LexA collection facilitates neuroendocrine and developmental biology investigations, and shows how empowering secondary school science can achieve research and educational goals.

  12. A Drosophila LexA Enhancer-Trap Resource for Developmental Biology and Neuroendocrine Research.

    Science.gov (United States)

    Kockel, Lutz; Huq, Lutfi M; Ayyar, Anika; Herold, Emma; MacAlpine, Elle; Logan, Madeline; Savvides, Christina; Kim, Grace E S; Chen, Jiapei; Clark, Theresa; Duong, Trang; Fazel-Rezai, Vahid; Havey, Deanna; Han, Samuel; Jagadeesan, Ravi; Kim, Eun Soo Jackie; Lee, Diane; Lombardo, Kaelina; Piyale, Ida; Shi, Hansen; Stahr, Lydia; Tung, Dana; Tayvah, Uriel; Wang, Flora; Wang, Ja-Hon; Xiao, Sarah; Topper, Sydni M; Park, Sangbin; Rotondo, Cheryl; Rankin, Anne E; Chisholm, Townley W; Kim, Seung K

    2016-10-13

    Novel binary gene expression tools like the LexA-LexAop system could powerfully enhance studies of metabolism, development, and neurobiology in Drosophila However, specific LexA drivers for neuroendocrine cells and many other developmentally relevant systems remain limited. In a unique high school biology course, we generated a LexA-based enhancer trap collection by transposon mobilization. The initial collection provides a source of novel LexA-based elements that permit targeted gene expression in the corpora cardiaca, cells central for metabolic homeostasis, and other neuroendocrine cell types. The collection further contains specific LexA drivers for stem cells and other enteric cells in the gut, and other developmentally relevant tissue types. We provide detailed analysis of nearly 100 new LexA lines, including molecular mapping of insertions, description of enhancer-driven reporter expression in larval tissues, and adult neuroendocrine cells, comparison with established enhancer trap collections and tissue specific RNAseq. Generation of this open-resource LexA collection facilitates neuroendocrine and developmental biology investigations, and shows how empowering secondary school science can achieve research and educational goals. Copyright © 2016 Kockel et al.

  13. Complementation pattern of lexB and recA mutations in Escherichia coli K12; mapping of tif-1, lexB and recA mutations

    International Nuclear Information System (INIS)

    Morand, P.; Goze, A.; Devoret, R.

    1977-01-01

    Three lexB mutations, whose phenotypes have been previously characterized, are studied here in relation to a few recA mutations as to their complementation pattern and relative location. The restoration of resistance to UV-light and to X-rays in the hetero-allelic diploid bacteria was used as a test for dominance and complementation. The wild type allele was always dominant over the mutant allele. Only partial complementation was found between lexB and two rexA alleles. There was no complementation between the recA alleles. All the data taken together strongly suggest that the complementations found are intragenic: lexB and recA mutations are in one gene. Mapping of lexB, recA and tif-1 mutations in relation to srl-1 and cysC by phage P1 transduction shows that lexB and the tif-1 mutations form a cluster proximal to srl-1 whereas recA mutations are located at the other extremity of the gene. Variability with temperature of cotransduction frequencies as well as their extended range of values prevent a meaningful calculation of the length of the recA gene. Our hypothesis is that the recA protein has two functional regions called A and B respectively defined at the genetical level by recA and lexB mutations and that it is, in vivo, an oligomeric protein forming a complex with the lexA protein. This complex is postulated to be multifunctional: recombination and control of exonuclease V are effected by the A region while the B region and lexA protein effect induced DNA repair and lysogenic induction. (orig.) [de

  14. Leptospira interrogans serovar copenhageni harbors two lexA genes involved in SOS response.

    Directory of Open Access Journals (Sweden)

    Luciane S Fonseca

    Full Text Available Bacteria activate a regulatory network in response to the challenges imposed by DNA damage to genetic material, known as the SOS response. This system is regulated by the RecA recombinase and by the transcriptional repressor lexA. Leptospira interrogans is a pathogen capable of surviving in the environment for weeks, being exposed to a great variety of stress agents and yet retaining its ability to infect the host. This study aims to investigate the behavior of L. interrogans serovar Copenhageni after the stress induced by DNA damage. We show that L. interrogans serovar Copenhageni genome contains two genes encoding putative LexA proteins (lexA1 and lexA2 one of them being potentially acquired by lateral gene transfer. Both genes are induced after DNA damage, but the steady state levels of both LexA proteins drop, probably due to auto-proteolytic activity triggered in this condition. In addition, seven other genes were up-regulated following UV-C irradiation, recA, recN, dinP, and four genes encoding hypothetical proteins. This set of genes is potentially regulated by LexA1, as it showed binding to their promoter regions. All these regions contain degenerated sequences in relation to the previously described SOS box, TTTGN 5CAAA. On the other hand, LexA2 was able to bind to the palindrome TTGTAN10TACAA, found in its own promoter region, but not in the others. Therefore, the L. interrogans serovar Copenhageni SOS regulon may be even more complex, as a result of LexA1 and LexA2 binding to divergent motifs. New possibilities for DNA damage response in Leptospira are expected, with potential influence in other biological responses such as virulence.

  15. Dialogues between the Convention on the International Sale of Goods (CISG and the Lex Mercatoria

    Directory of Open Access Journals (Sweden)

    María Fernanda Vásquez Palma

    2018-03-01

    Full Text Available This work analyzes the tight connection that exist between the CISG and the lex mercatoria, since the first embody the second. Amid these a sort of dialogue occurs. The lex mercatoria supply the CISG, either at the contract level or the normative, acting as a resource for the interpretation and integration, as well as the rule that govern the contract. The CISG, as manifestation of the lex mercatoria, operate in the same way, either as source for the integration of the contract, or as the rule applicable to international contracts.

  16. Bio-SimVerb and Bio-SimLex: wide-coverage evaluation sets of word similarity in biomedicine.

    Science.gov (United States)

    Chiu, Billy; Pyysalo, Sampo; Vulić, Ivan; Korhonen, Anna

    2018-02-05

    Word representations support a variety of Natural Language Processing (NLP) tasks. The quality of these representations is typically assessed by comparing the distances in the induced vector spaces against human similarity judgements. Whereas comprehensive evaluation resources have recently been developed for the general domain, similar resources for biomedicine currently suffer from the lack of coverage, both in terms of word types included and with respect to the semantic distinctions. Notably, verbs have been excluded, although they are essential for the interpretation of biomedical language. Further, current resources do not discern between semantic similarity and semantic relatedness, although this has been proven as an important predictor of the usefulness of word representations and their performance in downstream applications. We present two novel comprehensive resources targeting the evaluation of word representations in biomedicine. These resources, Bio-SimVerb and Bio-SimLex, address the previously mentioned problems, and can be used for evaluations of verb and noun representations respectively. In our experiments, we have computed the Pearson's correlation between performances on intrinsic and extrinsic tasks using twelve popular state-of-the-art representation models (e.g. word2vec models). The intrinsic-extrinsic correlations using our datasets are notably higher than with previous intrinsic evaluation benchmarks such as UMNSRS and MayoSRS. In addition, when evaluating representation models for their abilities to capture verb and noun semantics individually, we show a considerable variation between performances across all models. Bio-SimVerb and Bio-SimLex enable intrinsic evaluation of word representations. This evaluation can serve as a predictor of performance on various downstream tasks in the biomedical domain. The results on Bio-SimVerb and Bio-SimLex using standard word representation models highlight the importance of developing dedicated

  17. Sports Corruption: Sporting Autonomy, Lex Sportiva and the Rule of Law

    OpenAIRE

    Serby, Tom

    2017-01-01

    An apparent escalation in on-field corruption (doping and match-fixing) in professional sports has led to increasing numbers of athletes facing bans and a loss of livelihood as a consequence of decisions taken by sporting tribunals, as part of a regulatory system referred to as lex sportiva. This has led to challenges in domestic courts from athletes over the lawfulness and fairness of these proceedings (for example Pechstein and Kaneria). These challenges to the legitimacy of lex sportiva (a...

  18. RNA-seq profiling reveals novel target genes of LexA in the cyanobacterium Synechocystis sp. PCC 6803

    Directory of Open Access Journals (Sweden)

    Ayumi eKizawa

    2016-02-01

    Full Text Available LexA is a well-established transcriptional repressor of SOS genes induced by DNA damage in E. coli and other bacterial species. However, LexA in the cyanobacterium Synechocystis sp. PCC 6803 has been suggested not to be involved in SOS response. In this study, we performed RNA-seq analysis of the wild-type strain and the lexA-disrupted mutant to obtain the comprehensive view of LexA-regulated genes in Synechocystis. Disruption of lexA positively or negatively affected expression of genes related to various cellular functions such as phototactic motility, accumulation of the major compatible solute glucosylglycerol and subunits of bidirectional hydrogenase, photosystem I and phycobilisome complexes. We also observed increase in the expression level of genes related to iron and manganese uptake in the mutant at the later stage of cultivation. However, none of the genes related to DNA metabolism were affected by disruption of lexA. DNA gel mobility shift assay using the recombinant LexA protein suggested that LexA binds to the upstream region of pilA7, pilA9, ggpS and slr1670 to directly regulate their expression, but changes in the expression level of photosystem I genes by disruption of lexA is likely a secondary effect.

  19. Quelques remarques sur le nomadisme préhilalien au Maghreb (viiie-xie siècle)

    OpenAIRE

    Benhima, Yassir

    2011-01-01

    Cette étude propose un aperçu de l'histoire du nomadisme au Maghreb avant le début des migrations hilaliennes au milieu du xie siècle. Ce sujet demeure peu étudié en comparaison avec le nomadisme en Afrique du Nord à l'époque antique, dont la connaissance a connu récemment un grand développement. L'examen des sources arabes du haut Moyen Âge permet de constater la diversité des termes employés pour désigner les populations nomades et leur mode de vie. Les aspects résidentiels, territoriaux et...

  20. Regulation of the E. coli SOS response by the lexA gene product

    International Nuclear Information System (INIS)

    Brent, R.

    1983-01-01

    In an Escherichia coli that is growing normally, transcription of many genes is repressed by the product of the lexA gene. If cellular DNA is damaged, proteolytically competent recA protein (recA protease) inactivates lexA protein and these genes are induced. Many of the cellular phenomena observed during the cellular response to DNA damage (the SOS response) are the consequence of the expression of these lexA-prepressed genes. Since the SOS response of E. coli has recently been the subject of a comprehensive review, in this paper I would like to concentrate on some modifications to the picture based on new data. 12 references, 2 figures

  1. El papel de la societas mercatorum en la creación normativa: la lex mercatoria

    Directory of Open Access Journals (Sweden)

    Francisco López Ruiz

    2010-06-01

    Full Text Available En este trabajo se estudia el fenómeno de la creación privada del Derecho ligada al proceso de globalización económica. Más concretadamente, el papel de la societas mercatorum o business community  en la producción del Derecho.Se puede considerar como Derecho el conjunto de reglas – la lex mercatoria – elaboradas por asociaciones profesionales internacionales, grandes firmas de abogados y empresas transnacionales?. La tesis que mantendré es que la lex mercatoria  es, ciertamente un conjunto de reglas jurídicas altamente eficaces en el ámbito de los negocios internacionales. Sin embargo, tal eficacia no puede servir como criterio de legitimidad de la lex mercatoria.

  2. Lysogenic induction in Lex Al Escherichia coli mutants: characterization of the induction and prophage repressor influence

    International Nuclear Information System (INIS)

    Carvalho, R.E.S.

    1982-01-01

    SOS functions require new synthesis of protein and have been described as dependent on both the rec A and lex A genes. The induction of prophage was studied in bacterial strains lysogenic for a series of phages which synthesize different levels of repressor (λ, λ i m m 4 3 4 J and λ i m m 4 3 4 T ) and was compared to W-reactivation. Prophage induction was detected in lex Al mutants although at a slightly lower level and requiring two times longer when compared with wild-type. The optimum UV-dose for induction differed for each lysogenic strain and correlated with the level of repressor

  3. Reconocimiento de la lex mercatoria como normativa propia y apropiada para el comercio internacional

    Directory of Open Access Journals (Sweden)

    Maximiliano Rodríguez Fernández

    2012-12-01

    Full Text Available En el presente artículo queremos referirnos al concepto de la Lex Mercatoria, su validez, sus características, las tesis que profesan sus detractores y las de aquéllos que profesan su existencia, su valor normativo, así como sus manifestaciones actuales.

  4. Lexion: That Which Upholds or Bears an Archetype. "Introducing Lex and Lexion to Modern English"

    Science.gov (United States)

    Russ, Helen

    2015-01-01

    Derived from the Etruscan and Greek alphabets, Latin is a classical language that has influenced modern languages such as English, French, Italian and Spanish. With its Latin and Greek roots, this paper argues that the word lexion is an appropriate and necessary addition to the English language. Lex in Latin means, law, syllabus, statute and…

  5. From "TshwaneLex to TshwanePedia": Creating and Flexibly ...

    African Journals Online (AJOL)

    ware TshwaneLex suffices to turn this application into a tool for the creation and maintenance of encyclopaedias. This article gives a brief overview of those extra features, using the online encyclo-paedia of the James Randi Educational ...

  6. Femtosecond (FS) laser vision correction procedure for moderate to high myopia: a prospective study of ReLEx(®) flex and comparison with a retrospective study of FS-laser in situ keratomileusis

    DEFF Research Database (Denmark)

    Vestergaard, Anders; Ivarsen, Anders; Asp, Sven

    2013-01-01

    Purpose:  To present our initial clinical experience with ReLEx(®) flex (ReLEx) for moderate to high myopia. We compare efficacy, safety and corneal higher-order aberrations after ReLEx with femtosecond laser in situ keratomileusis (FS-LASIK). Methods:  Prospective study of ReLEx compared with a ...

  7. Effect of LexA on Chromosomal Integration of CTXϕ in Vibrio cholerae.

    Science.gov (United States)

    Pant, Archana; Anbumani, D; Bag, Satyabrata; Mehta, Ojasvi; Kumar, Pawan; Saxena, Shruti; Nair, G Balakrish; Das, Bhabatosh

    2016-01-15

    The genesis of toxigenic Vibrio cholerae involves acquisition of CTXϕ, a single-stranded DNA (ssDNA) filamentous phage that encodes cholera toxin (CT). The phage exploits host-encoded tyrosine recombinases (XerC and XerD) for chromosomal integration and lysogenic conversion. The replicative genome of CTXϕ produces ssDNA by rolling-circle replication, which may be used either for virion production or for integration into host chromosome. Fine-tuning of different ssDNA binding protein (Ssb) levels in the host cell is crucial for cellular functioning and important for CTXϕ integration. In this study, we mutated the master regulator gene of SOS induction, lexA, of V. cholerae because of its known role in controlling levels of Ssb proteins in other bacteria. CTXϕ integration decreased in cells with a ΔlexA mutation and increased in cells with an SOS-noninducing mutation, lexA (Ind(-)). We also observed that overexpression of host-encoded Ssb (VC0397) decreased integration of CTXϕ. We propose that LexA helps CTXϕ integration, possibly by fine-tuning levels of host- and phage-encoded Ssbs. Cholera toxin is the principal virulence factor responsible for the acute diarrheal disease cholera. CT is encoded in the genome of a lysogenic filamentous phage, CTXϕ. Vibrio cholerae has a bipartite genome and harbors single or multiple copies of CTXϕ prophage in one or both chromosomes. Two host-encoded tyrosine recombinases (XerC and XerD) recognize the folded ssDNA genome of CTXϕ and catalyze its integration at the dimer resolution site of either one or both chromosomes. Fine-tuning of ssDNA binding proteins in host cells is crucial for CTXϕ integration. We engineered the V. cholerae genome and created several reporter strains carrying ΔlexA or lexA (Ind(-)) alleles. Using the reporter strains, the importance of LexA control of Ssb expression in the integration efficiency of CTXϕ was demonstrated. Copyright © 2015, American Society for Microbiology. All Rights

  8. UV-lysogenic induction of lambda phage in lexAl mutants of Escherichia coli: kinetics of the process

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, R.E.S.; Leitao, A.C. (Rio de Janeiro Univ. (Brazil). Inst. de Biofisica)

    1984-05-01

    Although the lex gene has been described as being required for lysogenic induction, both this work and the work of others have reported lambda prophage induction in some lexA mutants. However, the characteristics of the process were not defined. UV induction of prophage in a lexAl mutant is described at a slightly lower level and requiring 2 times longer than the wild type. As demonstrated in some work, in cells treated with low levels of rifampicin (RIF) no new synthesis of RecA protein is needed for the prophage induction although the onset of lysis is delayed. It is suggested that the lysogenic induction in lexA cells is due to the same mechanism that induces prophage in the wild type cells treated with RIF. That is, the induction is due to the cleavage of lambda repressor by the basal RecA protease in the DNA-single-strand gap, since RecA protease and monomer repressor both have high affinity for this type of DNA. So, LexA protein need not be cleaved for the prophage induction. No Weigle-reactivation (WR) was detected in the lex mutant even after a long post-irradiation incubation, suggesting that unlike prophage induction, WR requires LexA protein cleavage.

  9. Evaluation and cross-comparison of lexical entities of biological interest (LexEBI.

    Directory of Open Access Journals (Sweden)

    Dietrich Rebholz-Schuhmann

    Full Text Available MOTIVATION: Biomedical entities, their identifiers and names, are essential in the representation of biomedical facts and knowledge. In the same way, the complete set of biomedical and chemical terms, i.e. the biomedical "term space" (the "Lexeome", forms a key resource to achieve the full integration of the scientific literature with biomedical data resources: any identified named entity can immediately be normalized to the correct database entry. This goal does not only require that we are aware of all existing terms, but would also profit from knowing all their senses and their semantic interpretation (ambiguities, nestedness. RESULT: This study compiles a resource for lexical terms of biomedical interest in a standard format (called "LexEBI", determines the overall number of terms, their reuse in different resources and the nestedness of terms. LexEBI comprises references for protein and gene entries and their term variants and chemical entities amongst other terms. In addition, disease terms have been identified from Medline and PubmedCentral and added to LexEBI. Our analysis demonstrates that the baseforms of terms from the different semantic types show only little polysemous use. Nonetheless, the term variants of protein and gene names (PGNs frequently contain species mentions, which should have been avoided according to protein annotation guidelines. Furthermore, the protein and gene entities as well as the chemical entities, both do comprise enzymes leading to hierarchical polysemy, and a large portion of PGNs make reference to a chemical entity. Altogether, according to our analysis based on the Medline distribution, 401,869 unique PGNs in the documents contain a reference to 25,022 chemical entities, 3,125 disease terms or 1,576 species mentions. CONCLUSION: LexEBI delivers the complete biomedical and chemical Lexeome in a standardized representation (http://www.ebi.ac.uk/Rebholz-srv/LexEBI/. The resource provides the disease terms as

  10. Two New Members of Freshwater Red Algae in Taiwan: Compsopogon tenellus Ling et Xie and C. chalybeus Kützing (Compsopogonaceae, Rhodophyta

    Directory of Open Access Journals (Sweden)

    Shao-Lun Liu

    2004-03-01

    Full Text Available Two freshwater red algae, Compsopogon tenellus Ling et Xie and C. chalybeus Kützing, are first reported to the freshwater algal flora of Taiwan. In this study, we describe in detail the morphology of them and compare the ecological differences of their habitats. Both of them were found in clear, warm (24-27 °C and running stream in low altitude plain areas of southern Taiwan.

  11. The LexA transcription factor regulates fatty acid biosynthetic genes in the cyanobacterium Synechocystis sp. PCC 6803.

    Science.gov (United States)

    Kizawa, Ayumi; Kawahara, Akihito; Takashima, Kosuke; Takimura, Yasushi; Nishiyama, Yoshitaka; Hihara, Yukako

    2017-10-01

    Specific transcription factors have been identified in various heterotrophic bacterial species that regulate the sets of genes required for fatty acid metabolism. Here, we report that expression of the fab genes, encoding fatty acid biosynthetic enzymes, is regulated by the global regulator LexA in the photoautotrophic cyanobacterium Synechocystis sp. PCC 6803. Sll1626, an ortholog of the well-known LexA repressor involved in the SOS response in heterotrophic bacteria, was isolated from crude extracts of Synechocystis by DNA affinity chromatography, reflecting its binding to the upstream region of the acpP-fabF and fabI genes. An electrophoresis mobility shift assay revealed that the recombinant LexA protein can bind to the upstream region of each fab gene tested (fabD, fabH, fabF, fabG, fabZ and fabI). Quantitative RT-PCR analysis of the wild type and a lexA-disrupted mutant strain suggested that LexA acts as a repressor of the fab genes involved in initiation of fatty acid biosynthesis (fabD, fabH and fabF) and the first reductive step in the subsequent elongation cycle (fabG) under normal growth conditions. Under nitrogen-depleted conditions, downregulation of fab gene expression is partly achieved through an increase in LexA-repressing activity. In contrast, under phosphate-depleted conditions, fab gene expression is upregulated, probably due to the loss of repression by LexA. We further demonstrate that elimination of LexA largely increases the production of fatty acids in strains modified to secrete free fatty acids. © 2017 The Authors The Plant Journal © 2017 John Wiley & Sons Ltd.

  12. Rapid HPLC Quantification Approach for Detection of Active Constituents in Modern Combinatorial Formula, San-Huang-Xie-Xin-Tang (SHXXT

    Directory of Open Access Journals (Sweden)

    Tung-Ying Wu

    2016-10-01

    Full Text Available San-Huang-Xie-Xin-Tang (SHXXT, one of the most important traditional Chinese medicinal formulas, is comprised by three herbal medicines, the rhizome of Rheum officinale [or R. tanguticum (Polygonaceae (Dahuang in Chinese], the root of Scutellaria baicalensis (Labiatae (Huangqin in Chinese, and the rhizome of Coptis chinensis (Ranunculaceae (Huanglian in Chinese in the ratios of 2:1:1 or 1:1:1. This study is aimed to quantitate and qualify of SHXXT, by a rapid, convenient, and effective HPLC-PDA approach associated with LC-MS technique. Of which method, nine chosen major bioactive components in SHXXT, including aloe-emodin (Ale, baicalin (Ba, berberine (Be, coptisine (Co, palmatine (Pa, resveratroloside (Res, rhein (Rh, sennoside A (Se-A, and wogonin (Wo, were evaluated within 30 minutes. The nine chemical markers were monitored in a high sensitivity with a low detection limit of 0.01‒0.55 μg/mL and the correlation coefficient of the regression curve revealed a good linearity with R2 > 0.99. Moreover, the extraction solution system and the HPLC elution conditions were also optimized in the present study. This present developed protocol was then successfully applied to quantify nine chemical markers of ten SHXXT products from eight Taiwanese TCM pharmaceutical companies. In quantitative results, Res was found as the major compound in SHXXT-1~5 & 8 with significantly higher amounts than those in other products, indicating the products SHXXT-1~5 & 8 may use R. tanguticum as the raw material, which possessed a higher concentration of the bioactive composition Res, instead of R. officinale. Simultaneously, Ale, Rh, and Wo were less than 2% in these ten products. Different chemical profiles of commercial products indicated that, probably, each product with the same named formula might be regarded as a sole medicine and need to be investigated individually. Importantly, it is never too much to emphasize the importance of quality control in TCM

  13. [Refractive lenticule extraction - The ReLEx/SMILE technique : Video article].

    Science.gov (United States)

    Blum, M; Sekundo, W

    2017-09-01

    Refractive lenticule extraction (ReLEx/SMILE) is a refractive surgical method developed by the authors in stages primarily for correction of myopia and myopic astigmatism, in which a femtosecond laser is exclusively used. In the (ReLEx/SMILE) method a refractive lenticule is generated by the femtosecond laser, which is subsequently extracted through a small incision. Opening of the corneal surface with a flap and use of an excimer laser is no longer necessary. In 2013 the method was newly assessed and classified by the Joint Commisssion for Refractive Surgery (KRC) of the Professional Association of Ophthalmologists (BVA) and the German Ophthalmological Society (DOG). This article presents the individual stages of the technique in a video and possible errors and their avoidance are explained.

  14. [RadLex - German version: a radiological lexicon for indexing image and report information].

    Science.gov (United States)

    Marwede, D; Daumke, P; Marko, K; Lobsien, D; Schulz, S; Kahn, T

    2009-01-01

    Since 2003 the Radiological Society of North America (RSNA) has been developing a lexicon of standardized radiological terms (RadLex) intended to support the structured reporting of imaging observations and the indexing of teaching cases. The aim of this study was to translate the first version of the lexicon (1 - 2007) into German and to implement a language-independent online term browser. RadLex version 1 - 2007 contains 6303 terms in nine main categories. Two radiologists independently translated the lexicon using medical dictionaries. Terms translated differently were revised and translated by consensus. For the development of an online term browser, a text processing algorithm called morphosemantic indexing was used which splits up words into small semantic units and compares those units to language-specific subword thesauri. In total 6240 of 6303 terms (99 %) were translated. Of those terms 3965 were German, 1893 were Latin, 359 were multilingual, and 23 were English terms that are also used in German and were therefore maintained. The online term browser supports a language-independent term search in RadLex (German/English) and other common medical terminology (e. g., ICD 10). The term browser displays term hierarchies and translations in different frames and the complexity of the result lists can be adapted by the user. RadLex version 1 - 2007 developed by the RSNA is now available in German and can be accessed online through a term browser with an efficient search function. This is an important precondition for the future comparison of national and international indexed radiological examination results and the interoperability between digital teaching resources.

  15. RadLex - German version: a radiological lexicon for indexing image and report information

    International Nuclear Information System (INIS)

    Marwede, D.; Lobsien, D.; Kahn, T.; Daumke, P.; Marko, K.; Schulz, S.

    2009-01-01

    Purpose: Since 2003 the Radiological Society of North America (RSNA) has been developing a lexicon of standardized radiological terms (RadLex) intended to support the structured reporting of imaging observations and the indexing of teaching cases. The aim of this study was to translate the first version of the lexicon (1 - 2007) into German and to implement a language-independent online term browser. Materials and Methods: RadLex version 1 - 2007 contains 6303 terms in nine main categories. Two radiologists independently translated the lexicon using medical dictionaries. Terms translated differently were revised and translated by consensus. For the development of an online term browser, a text processing algorithm called morphosemantic indexing was used which splits up words into small semantic units and compares those units to language-specific subword thesauri. Results: In total 6240 of 6303 terms (99 %) were translated. Of those terms 3965 were German, 1893 were Latin, 359 were multilingual, and 23 were English terms that are also used in German and were therefore maintained. The online term browser supports a language-independent term search in RadLex (German/English) and other common medical terminology (e.g., ICD 10). The term browser displays term hierarchies and translations in different frames and the complexity of the result lists can be adapted by the user. Conclusion: RadLex version 1 - 2007 developed by the RSNA is now available in German and can be accessed online through a term browser with an efficient search function. This is an important precondition for the future comparison of national and international indexed radiological examination results and the interoperability between digital teaching resources. (orig.)

  16. From TshwaneLex to TshwanePedia: Creating and Flexibly Maintaining Online Encyclopaedias

    Directory of Open Access Journals (Sweden)

    Gilles-Maurice De Schryver

    2011-10-01

    Full Text Available

    ABSTRACT: The addition of a restricted number of features to the dictionary (compilation soft-ware TshwaneLex suffices to turn this application into a tool for the creation and maintenance of encyclopaedias. This article gives a brief overview of those extra features, using the online encyclo-paedia of the James Randi Educational Foundation (JREF as case study.


    Keywords: LEXICOGRAPHY, DICTIONARY, ENCYCLOPAEDIA, SOFTWARE, ONLINE, TSHWANELEX, TSHWANEPEDIA, JAMES RANDI EDUCATIONAL FOUNDATION


    *****

    SAMEVATTING: Van TshwaneLex naar TshwanePedia: het samenstellen en flexibel herzien van on line encyclopedieën. De toevoeging van een beperkt aantal uitbreidingen aan de woordenboek(aanmaaksoftware TshwaneLex is voldoende om dit programma met succes voor de samenstelling en herziening van encyclopedieën in te zetten. Dit artikel geeft een kort overzicht van die extra uitbreidingen, en gebruikt de on line encyclopedie van de James Randi Educational Foundation (JREF als illustratie.


    Sleutelwoorden: LEXICOGRAFIE, WOORDENBOEK, ENCYCLOPEDIE, SOFTWARE, ON LINE, TSHWANELEX, TSHWANEPEDIA, JAMES RANDI EDUCATIONAL FOUNDATION

  17. Investigation of lethal and mutagenetic effects of UV-light on Salmonella currying wild and mutant alleles of lex A gene of Escherichia coli in the Salmonella genome

    International Nuclear Information System (INIS)

    Andreeva, I.V.; Tiganova, I.G.; Skavronskaya, A.G.

    1981-01-01

    Inheritance of LexA-gene of Escherichia coli- by Salmonella takes place during intergeneric trunsduction cross of Escherichia coli and Salmonella typhimurium. The presence of LexA-E. coli gene-did not eliminate earlier revealed peculiarity consisting in the absence of UV-induced mutagenesis in most of studied salmonollosis strains. So it is shown that the absence of UV mutagenesis in Salmonella does not result from mutation in LexA-gene. Inheritance of pKM101 by LexA-hybrid provides pronounced UV mutability and protective effect. Inheritance of this plasmid by LexA-hybrid did not result in the appearance of capability for UV-induced mutagenesis and improving UV resistance of bacteria. Thus the plasmids effect on repair and mutagenesis in Salmonella, the same as in E. coli, reveals in LexA-phenotype [ru

  18. Conservation of the LexA repressor binding site in Deinococcus radiodurans

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    Khan Feroz

    2008-03-01

    Full Text Available The LexA protein is a transcriptional repressor of the bacterial SOS DNA repair system, which comprises a set of DNA repair and cellular survival genes that are induced in response to DNA damage. Its varied DNA binding motifs have been characterized and reported in the Escherichia coli, Bacillus subtilis, rhizobia family members, marine magnetotactic bacterium, Salmonella typhimurium and recently in Mycobacterium tuberculosis and this motifs information has been used in our theoretical analysis to detect its novel regulated genes in radio-resistant Deinococcus radiodurans genome. This bacterium showed presence of SOS-box like consensus sequence in the upstream sequences of 3166 genes with >60% motif score similarity percentage (MSSP on both strands. Attempts to identify LexA-binding sites and the composition of the putative SOS regulon in D. radiodurans have been unsuccessful so far. To resolve the problem we performed theoretical analysis with modifications on reported data set of genes related to DNA repair (61 genes, stress response (145 genes and some unusual predicted operons (21 clusters. Expression of some of the predicted SOS-box regulated operon members then was examined through the previously reported microarray data which confirm the expression of only single predicted operon i.e. DRB0143 (AAA superfamily NTPase related to 5-methylcytosine specific restriction enzyme subunit McrB and DRB0144 (homolog of the McrC subunit of the McrBC restriction modification system. The methodology involved weight matrix construction through CONSENSUS algorithm using information of conserved upstream sequences of eight known genes including dinB, tagC, lexA, recA, uvrB, yneA of B. subtilis while lexA and recA of D. radiodurans through phylogenetic footprinting method and later detection of similar conserved SOS-box like LexA binding motifs through both RSAT & PoSSuMsearch programs. The resultant DNA consensus sequence had highly conserved 14 bp SOS

  19. Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic-Industry Partnership.

    Science.gov (United States)

    Mo, Charlie Y; Culyba, Matthew J; Selwood, Trevor; Kubiak, Jeffrey M; Hostetler, Zachary M; Jurewicz, Anthony J; Keller, Paul M; Pope, Andrew J; Quinn, Amy; Schneck, Jessica; Widdowson, Katherine L; Kohli, Rahul M

    2018-03-09

    The RecA/LexA axis of the bacterial DNA damage (SOS) response is a promising, yet nontraditional, drug target. The SOS response is initiated upon genotoxic stress, when RecA, a DNA damage sensor, induces LexA, the SOS repressor, to undergo autoproteolysis, thereby derepressing downstream genes that can mediate DNA repair and accelerate mutagenesis. As genetic inhibition of the SOS response sensitizes bacteria to DNA damaging antibiotics and decreases acquired resistance, inhibitors of the RecA/LexA axis could potentiate our current antibiotic arsenal. Compounds targeting RecA, which has many mammalian homologues, have been reported; however, small-molecules targeting LexA autoproteolysis, a reaction unique to the prokaryotic SOS response, have remained elusive. Here, we describe the logistics and accomplishments of an academic-industry partnership formed to pursue inhibitors against the RecA/LexA axis. A novel fluorescence polarization assay reporting on RecA-induced self-cleavage of LexA enabled the screening of 1.8 million compounds. Follow-up studies on select leads show distinct activity patterns in orthogonal assays, including several with activity in cell-based assays reporting on SOS activation. Mechanistic assays demonstrate that we have identified first-in-class small molecules that specifically target the LexA autoproteolysis step in SOS activation. Our efforts establish a realistic example for navigating academic-industry partnerships in pursuit of anti-infective drugs and offer starting points for dedicated lead optimization of SOS inhibitors that could act as adjuvants for current antibiotics.

  20. ARBITRATION AND LEX SPORTIVA: THE CASE OF THE COURT OF ARBITRATION FOR SPORT (CAS

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    Mateus de Oliveira Fornasier

    2017-08-01

    Full Text Available The subject of the present work is the sport arbitration at a global level, delimiting the field of study to the performance of the Court of Arbitration for Sport (CAS as a decision-making body. The problem that led to the elaboration of this work was: how does the Court of Arbitration for Sport (CAS form part of the decision-making body with juridical characteristics? Its main hypothesis is that the Court for Arbitration of Sport (CAS is the highest instance of a non-state, but global, legal order whose decisions are competent not only for issues of purely sporting interest but also that set precedents for itself (which makes it selfreferential and also concerns about issues pertaining to the fundamental rights of athletes and organizations. Main objective: to analyze, from basic notions of the Theory of Autopoietic Social Systems (such as complexity, transnationalization and autopoiesis the Lex Sportiva and the Arbitral Court of Sport.Specific objectives: i to observe Lex Sportiva, a non-state and transnational legal order arising from the regulation of the most varied professional sports; ii to approach the CAS as the main center of juridicity in this multicentric order. Methodology: systemic-constructivist. Results: i the emergence of Lex Sportiva in the hypercomplex, polyontextural and globalized society constitutes a true non-state legal order, whose autonomy, legitimacy and binding force are recognized by state orders; ii its normative and decision-making processes deal with issues of high relevance not only to the sport itself but also to fundamental freedoms; iii the CAS, in this context, reveals itself as a true non-state maximum court, whose decisions are fundamentally relevant to various aspects of the life of those involved in sports activities.

  1. Dictionary Writing System (DWS + Corpus Query Package (CQP: The Case of TshwaneLex

    Directory of Open Access Journals (Sweden)

    Gilles-Maurice de Schryver

    2011-10-01

    Full Text Available

    Abstract: In this article the integrated corpus query functionality of the dictionary compilation software TshwaneLex is analysed. Attention is given to the handling of both raw corpus data and annotated corpus data. With regard to the latter it is shown how, with a minimum of human effort, machine learning techniques can be employed to obtain part-of-speech tagged corpora that can be used for lexicographic purposes. All points are illustrated with data drawn from English and Northern Sotho. The tools and techniques themselves, however, are language-independent, and as such the encouraging outcomes of this study are far-reaching.

    Keywords: LEXICOGRAPHY, DICTIONARY, SOFTWARE, DICTIONARY WRITING SYS-TEM (DWS, CORPUS QUERY PACKAGE (CQP, TSHWANELEX, CORPUS, CORPUS ANNO-TATION, PART-OF-SPEECH TAGGER (POS-TAGGER, MACHINE LEARNING, NORTHERN SOTHO (SESOTHO SA LEBOA

    Samenvatting: Woordenboekaanmaaksysteem + corpusanalysepakket: een studie van TshwaneLex. In dit artikel wordt het geïntegreerde corpusanalysepakket van het woordenboekaanmaaksysteem TshwaneLex geanalyseerd. Aandacht gaat zowel naar het verwer-ken van onbewerkte corpusdata als naar geannoteerde corpusdata. Wat het laatste betreft wordt aangetoond hoe, met een minimum aan intellectuele arbeid, automatische leertechnieken met suc-ces kunnen worden ingezet om corpora voor lexicografische doeleinden aan te maken waarin de woordklassen expliciet worden vermeld. Alle stappen van de redenering worden geïllustreerd met gegevens uit het Engels en Noord-Sotho. De instrumenten en technieken zelf zijn echter allemaal taalonafhankelijk, waardoor de veelbelovende resultaten van deze studie verreikend zijn.

    Sleutelwoorden: LEXICOGRAFIE, WOORDENBOEK, SOFTWARE, WOORDENBOEK-AANMAAKSYSTEEM, CORPUSANALYSEPAKKET, TSHWANELEX, CORPUS, CORPUSANNO-TATIE, WOORDKLASSETAGGER, AUTOMATISCHE LEERTECHNIEKEN, NOORD-SOTHO

  2. El contrato administrativo: ¿lex inter partes o ius vivandi?

    Directory of Open Access Journals (Sweden)

    Pedro José Jorge Coviello

    2011-12-01

    Full Text Available En el presente trabajo se estudia si en los contratos públicos el principio de observancia de los pactado (pacta sunt servanda, o lex inter pares tiene preponderancia sobre el principio del ius vivandi típico de los contratos administrativos. Se busca, a través del estudio del derecho comparado y de la doctrina que originó ambos principios, llegara a una síntesis de ambos. Mediante la aplicación del principio de la legalidad, se trata de arribar a un equilibrio de ambos, sin perjuicio de reconocer el autor la preeminencia del principio contrato-ley.

  3. The principle of certainty of criminal law (lex certa in case law of the European Court of Rights

    Directory of Open Access Journals (Sweden)

    Stojanović Anđela

    2011-01-01

    Full Text Available Article 7 of the Convention is not confined to prohibition of the retrospective application of the criminal law. Provided protection is wider, and it is developed through the case law of the European Court of Human Rights. Because of the significant impact of the common law, Article 7 in general can not be understood in a way that the principle of legality is traditionally recognized in civil law. As for the lex certa principle, the case law of domestic courts has a big impact on the Court. This is of course the consequence of common law impact. Although lex certa is in some degree a relative principle, in some of the Court criteria's lies the danger of its further relativization. In its previous case law, the Court found violation of this principle in only one case. It remains to the future case law to further clarify in what extent lex certa principle is recognized by the Court.

  4. CONDITIONS AND EFFECTS OF THE COMMISSORIA LEX IN THE LEASING CONTRACT

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    Raluca Tomescu

    2015-11-01

    Full Text Available The main problem with the execution of a leasing contract in Romania is that there are still shortcomings to the laws in force. The complexity of this contract which, at first sight, seems so commonplace, as well as the void in our ambiguous law are an inexhaustible source of research and exploration, but also the origin of controversial conflicts. With this paper I decided to elaborate I would like to contribute to consolidating the ”status” of national leasing operations, which are still in search of their own identity. Aiming to place the leasing contract back in its rightful place, that of a contract from which nobody has anything to lose but everything to gain, I consider it appropriate to analyse the conditions and effects of the commissoria lex fragments inserted in the leasing contract. One of the most controversial aspect of these last years brought to the attention of the courts of law cases where the financier, once the leasing contract was cancelled, requests the foreclosure of the user. The cancellation we are taking into account is based on the commissoria lex inserted in the clauses of the leasing contract. We have therefore to an alyse whether the foreclosure of the user can be carried on, based on the provisions of GO 51/1997 referring to leasing contracts.

  5. Zukunft der E-Books: Innovationen und Geschäftsmodelle von Verlagen für Medizinbibliotheken an Hochschulen: Je drei Fragen von Bruno Bauer an Klaus Bahmann (Springer, Peter Gemmel (Thieme und Angelika Lex (Elsevier / The future of e-books: innovations and business plan of publishers for medical libraries at universities: 3 questions to Klaus Bahmann (Springer, Peter Gemmel (Thieme and Angelika Lex (Elsevier by Bruno Bauer

    Directory of Open Access Journals (Sweden)

    Lex, Angelika

    2010-05-01

    Full Text Available In the past years electronic books were booming at scientific libraries. E-books have established especially at medical libraries as an important part of the document supply in particular for students.The current interview with Klaus Bahmann (Springer, Peter Gemmel (Thieme and Angelika Lex (Elsevier informs about development, situation and outlook of e-books of three big scientific publishers. They spoke about the focal points in the supply and the diverse business models and the different estimation for the future development of electronic books.

  6. Valoració de les pràxies bucofacials i la percepció auditiva en infants d'educació infantil i primària

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    María del Carmen Busto Barcos

    2013-03-01

    Full Text Available El material interactivo Valoració de les Pràxies Bucofacials i la Percepció Auditiva en Infants d’Educació Infantil i Primària, coordinado por la profesora Mª Carmen Busto, continúa y completa el material que ya presentamos en el volumen 1 de la Biblioteca Phonica, Avaluació del desenvolupament fonològic en nens catalanoparlants de 3, 4 i 5 anys d’edat. Ambos trabajos fueron realizados con la ayuda de sendos proyectos de innovación docente (Millora a la Innovació Docent de la Universitat de Barcelona. Junto con el artículo Valoración del habla en niños de educación infantil y primaria, que presentamos también en este número 4 de la revista Phonica, estos materiales están dirigidos al conjunto de educadores y terapeutas del habla de nuestra comunidad educativa y están llamados a ser una referencia clave en la valoración del desarrollo fonológico en las primeras edades.

  7. Las restricciones de la producción tegularia en la Lex Ursonensis

    Directory of Open Access Journals (Sweden)

    V.G. TSIOLIS

    2010-02-01

    Full Text Available RESUMEN: Sobre las cuestiones de índole semántico que plantea la primera parte del capítulo LXXVl de la Lex, que regula la producción de tejas in oppido, se efectúan aquí algunas reflexiones críticas en torno a aspectos técnicos de las instalaciones tejeras que podrían contribuir a esclarecer parte de las aparentes incongruencias filológicas, tradicionalmente detectadas en el apartado de las sanciones.Así mismo, se debate el carácter extremadamente riguroso de estas sanciones, hecho que induce a la sospecha de que el legislador fuese movido por imperativos políticos más que por razones urbanísticas, ecológicas o financieras.ABSTRACT: In this paper some critical reflexions are expressed, concerning tecnical aspectcs of tile-produccion instalations, which could contribute to elucidate partly some of the apparent philological incongruities, traditional detected in the second part of the same chapter where the sanctions are established. In the same manner, the carácter, extremely severe, of such sanctions is discussed, a fact inducing to suspect that legislator was moving from political rather than urbanistic, ecological or financial imperatives.

  8. El esperpento en el cine de Álex de la Iglesia.

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    Marta RIVERO FRANCO

    2015-06-01

    Full Text Available Varios son los estudios que aluden a la presencia del esperpento en el cine de Álex de la Iglesia —tema ligado taxativamente a su producción y sin el que esta no puede entenderse—, pero escasos los que profundizan en la manera en la que este recurso se ve plasmado en sus creaciones. Por ello, con el presente trabajo, nos disponemos a analizar la forma en la que el esperpento se manifiesta en su filmografía, para lo que seleccionaremos tres de sus ficciones esenciales —El día de la bestia (1995, La comunidad (2000 y Balada triste de trompeta (2010—, a través de las que comprobaremos cómo la intertextualidad, la crítica social y esa mezcla de cultura posmoderna con resonancias de la España más atávica, son las características que constituyen la esencia de tan idiosincrático recurso dentro de su producción.

  9. Les golems du numérique droit d'auteur et Lex Electronica

    CERN Document Server

    Dulong de Rosnay, Mélanie

    2016-01-01

    Le droit d’auteur, élaboré sur les fondements analogiques de la rareté du support, est remis en question par le numérique, qui s’appuie sur la copie, la réappropriation et le partage. Il a été adapté au rythme des innovations techniques de reproduction et de diffusion et peut conduire aussi bien au contrôle de l’accès qu’à la constitution de biens communs. Les processus d’élaboration des normes et standards techniques et d’extension des droits ont été pensés de manière indépendante, entraînant des tensions entre les industries culturelles et les droits du public. L’ouvrage propose un modèle techno-juridique de la régulation du partage de la culture. Fondé sur la lex informatica, il intègre code juridique et code informatique pour exprimer les informations sur les droits et élargir les catégories actuelles du droit d’auteur pour faciliter l’utilisation, la création et le partage non marchand. Ce livre est basé sur plus de dix ans de participation à la régulat...

  10. Differential expression of SOS genes in an E. coli mutant producing unstable lexA protein enhances excision repair but inhibits mutagenesis

    International Nuclear Information System (INIS)

    Peterson, K.R.; Ganesan, A.K.; Mount, D.W.; Stanford Univ., CA)

    1986-01-01

    The SOS response is displayed following treatments which damage DNA or inhibit DNA replication. Two associated activities include enhanced capacity for DNA repair resulting from derepression of the recA, uvrA, uvrB and uvrD genes and increased mutagenesis due to derepression of recA, umuC and umuD. These changes are the consequence of the derepression of at least seventeen unlinked operons negatively regulated by LexA repressor. Following treatments that induce the SOS response, a signal molecule interacts with RecA protein, converting it to an activated form. Activated RecA protein facilitates the proteolytic cleavage of LexA repressor, which results in derepression of the regulon. The cell then enters a new physiological state during which time DNA repair processes are augmented. The lexA41 mutant of E. coli is a uv-resistant derivative of another mutant, lexA3, which produces a repressor that is not cleaved following inducing treatments. The resultant protein is unstable. Lac operon fusions to most of the genes in the SOS regulon were used to show that the various damage-inducible genes were derepressed to different extents. uvrA, B, and D were almost fully derepressed. Consistent with this finding, the rate of removal of T4 endonuclease V-sensitive sites was more rapid in the uv-irradiated lexA41 mutant than in normal cells, suggesting a more active excision repair system. We propose that the instability of the LexA41 protein reduces the intracellular concentration of repressor to a level that allows a high level of excision repair. The additional observation that SOS mutagenesis was only weakly induced in a lexA41 uvrA - mutant implies that the mutant protein partially represses one or more genes whose products promote SOS mutagenesis. 17 refs., 4 figs., 1 tab

  11. The dorsal striatum and ventral striatum play different roles in the programming of social behaviour: a tribute to Lex Cools.

    Science.gov (United States)

    van den Bos, Ruud

    2015-02-01

    Early work by Lex Cools suggested that the caudate nucleus (dorsal striatum) plays a role in programming social behaviour: enhanced activity in the caudate nucleus increased the extent to which ongoing behaviour is controlled by the individual's own behaviour (internal control) rather than by that of its partners (external control). Interestingly, later studies by others have indicated that the ventral striatum plays a role in external rather than internal control. Here, I discuss the role of these different striatal areas - and the emotional (ventral striatum) and cognitive control (dorsal striatum) system in which they are embedded - in the organization of social behaviour in the context of locus of control. Following on from this discussion, I will pay particular attention to individual differences in social behaviour (individuals with more internal or external control), focusing on the role of dopamine, serotonin and the effects of stress-related challenges in relation to their different position in a dominance hierarchy. I will subsequently allude to potential psychological and behavioural problems in the social domain following on from these differences in locus of control ['social obliviousness' (dorsal stratum) and 'social impulsivity' (ventral striatum)]. In doing so, I provide as a tribute a historical account of the early research by Lex Cools.

  12. The quest for a non-conflictual coexistence of international human rights law and humanitarian law: which role for the lex specialis principle?

    NARCIS (Netherlands)

    d' Aspremont, J.; Tranchez, E.; Kolb, R.; Gaggioli, G.

    2013-01-01

    International Humanitarian Law (hereafter IHL) and International Human Rights Law (hereafter HRL) undoubtedly share some kinship. Yet, most international lawyers and judges, confronted with the simultaneous application of these two sets of norms have made a resort to the principle lex specialis

  13. La Convención de Viena sobre la compraventa internacional de mercancías como lex mercatoria

    Directory of Open Access Journals (Sweden)

    José Luis Marín

    2009-12-01

    Full Text Available El presente artículo, desarrollado en el marco de una conferencia sobre la materia, tiene como finalidad mostrar el papel que juega la Convención de Viena de 1980 sobre la compraventa internacional de mercancías en el desarrollo del comercio internacional y su aplicación en los diferentes ordenamientos nacionales, bien sea directamente como una ley positiva o como una costumbre mercantil o lex mercatoria. Todo ello para mostrar que si bien existen muchos Estados que aún no han ratificado esta Convención, eso no es óbice para que la misma no pueda ser aplicada de una forma subsidiaria en el evento de que estemos en presencia de un litigio que tenga las características exigidas para los casos de compraventa internacional de mercancías.

  14. Measures Matter: The Local Exposure/Isolation (LEx/Is) Metrics and Relationships between Local-Level Segregation and Breast Cancer Survival.

    Science.gov (United States)

    Bemanian, Amin; Beyer, Kirsten M M

    2017-04-01

    Background: The Black-to-White disparity in breast cancer survival is increasing, and racial residential segregation is a potential driver for this trend. However, study findings have been mixed, and no study has comprehensively compared the effectiveness of different local-level segregation metrics in explaining cancer survival. Methods: We proposed a set of new local segregation metrics named local exposure and isolation (LEx/Is) and compared our new local isolation metric with two related metrics, the location quotient (LQ) and the index of concentration at extremes (ICE), across the 102 largest U.S. metropolitan areas. Then, using case data from the Milwaukee, WI, metropolitan area, we used proportional hazards models to explore associations between segregation and breast cancer survival. Results: Across the 102 metropolitan areas, the new local isolation metric was less skewed than the LQ or ICE. Across all races, Hispanic isolation was associated with poorer all-cause survival, and Hispanic LQ and Hispanic-White ICE were found to be associated with poorer survival for both breast cancer-specific and all-cause mortality. For Black patients, Black LQ was associated with lower all-cause mortality and Black local isolation was associated with reduced all-cause and breast cancer-specific mortality. ICE was found to suffer from high multicollinearity. Conclusions: Local segregation is associated with breast cancer survival, but associations varied based on patient race and metric employed. Impact: We highlight how selection of a segregation measure can alter study findings. These relationships need to be validated in other geographic areas. Cancer Epidemiol Biomarkers Prev; 26(4); 516-24. ©2017 AACR See all the articles in this CEBP Focus section, "Geospatial Approaches to Cancer Control and Population Sciences." ©2017 American Association for Cancer Research.

  15. Nueva lex mercatoria: mutación, derecho flexible y crisis de la seguridad jurídica en el espacio de la negociación transnacional

    Directory of Open Access Journals (Sweden)

    Orielo Alarcón Altamar

    2012-01-01

    Full Text Available ResumenEl presente artículo busca reflexionar sobre el debate en torno al resurgimiento o existencia de una Lex mercatoria, presentando argumentos que demuestran la existencia de dicha ley como la expresión de un derecho espontáneo, elástico, mutante, que emerge en el escenario de la negociación mercantil conservando algunos rasgos de la tradición jurídica pre moderna. Esta Lex mercatoria se presenta en el marco de un Derecho en crisis guiado por los requerimientos de nuevos protagonistas además de instrumentos jurídicos ágiles, flexibles, que al mismo tiempo poseen una asimetría y una dinámica particular. Por estas razones se considera que lo que suele denominarse desarrollo económico debe ir acompañado de un proceso creciente, de una democratización de las esferas y nuevos sistemas de producción de normas jurídicas.Palabras clavesLex mercatoria, derecho flexible, seguridad jurídica, negociación transnacional.AbstractThe present article seeks to think about the debate concerning the reappearance or existence of one kind of law called the Lex mercatoria, presenting arguments that demonstrate the existence of the above mentioned law as the expression of a spontaneous, elastic right, mutant, who emerges in the scene of the mercantile negotiation preserving some features of the juridical tradition premodern. This lex mercatoria appears in the frame of a right in crisis guided by the requirements of new protagonists besides juridical agile, flexible instruments that the same time possess an asymmetry and a particular dynamics. For these reasons it thinks that what is in the habit of being named an economic development must go accompanied of an increasing process of a democratization of the spheres and new systems of production of juridical procedure.Key wordsLex mercatoria, right flex, juridical safety, transnational negotiation.

  16. Les peintures murales dans les anciens territoires de Bourgogne (xie-xiie siècles. De Berzé-la-Ville à Rome et d’Auxerre à Compostelle

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    Juliette Rollier-Hanselmann

    2010-10-01

    Full Text Available L'étude des peintures murales de Bourgogne est complexe et doit être mise en relation avec le contexte historique et géopolitique de l’époque. Le duché de Bourgogne se trouvait dans une position stratégique entre le royaume de France et l’empire germanique. L’implantation de Cluny à la frontière de ces deux grands territoires marqua d’une façon particulière la région et eut des implications fortes dans toute la chrétienté occidentale. Nous avons réuni un corpus de peintures murales des xie et...

  17. Sobre la función social de la paternidad adoptiva desde la Lex Romana Visigothorum hasta la época del rey Alfonso X el Sabio

    Directory of Open Access Journals (Sweden)

    Manuel Baelo Álvarez

    2015-12-01

    Full Text Available This paper contributes to the study of the social function of adoptive parenthood (adoptio & adrogatio in the Lex Romana Visigothorum or Breviario de Alarico (506 d.C during the reconquest after the islamic invasion in the Municipal Fueros and the code of laws (Fuero of Soria, Fuero Real and Siete Partidas during the reign of Alfonso X the Wise (1252-1284.

  18. Ontology-based image navigation: exploring 3.0-T MR neurography of the brachial plexus using AIM and RadLex.

    Science.gov (United States)

    Wang, Kenneth C; Salunkhe, Aditya R; Morrison, James J; Lee, Pearlene P; Mejino, José L V; Detwiler, Landon T; Brinkley, James F; Siegel, Eliot L; Rubin, Daniel L; Carrino, John A

    2015-01-01

    Disorders of the peripheral nervous system have traditionally been evaluated using clinical history, physical examination, and electrodiagnostic testing. In selected cases, imaging modalities such as magnetic resonance (MR) neurography may help further localize or characterize abnormalities associated with peripheral neuropathies, and the clinical importance of such techniques is increasing. However, MR image interpretation with respect to peripheral nerve anatomy and disease often presents a diagnostic challenge because the relevant knowledge base remains relatively specialized. Using the radiology knowledge resource RadLex®, a series of RadLex queries, the Annotation and Image Markup standard for image annotation, and a Web services-based software architecture, the authors developed an application that allows ontology-assisted image navigation. The application provides an image browsing interface, allowing users to visually inspect the imaging appearance of anatomic structures. By interacting directly with the images, users can access additional structure-related information that is derived from RadLex (eg, muscle innervation, muscle attachment sites). These data also serve as conceptual links to navigate from one portion of the imaging atlas to another. With 3.0-T MR neurography of the brachial plexus as the initial area of interest, the resulting application provides support to radiologists in the image interpretation process by allowing efficient exploration of the MR imaging appearance of relevant nerve segments, muscles, bone structures, vascular landmarks, anatomic spaces, and entrapment sites, and the investigation of neuromuscular relationships. RSNA, 2015

  19. The pedagogical benefits of a lexical database (SciE-Lex to assist the production of publishable biomedical texts by EAL writers

    Directory of Open Access Journals (Sweden)

    Natalia Judith Laso

    2017-04-01

    Full Text Available Research has demonstrated that it is challenging for English as an Additional Language (EAL writers to acquire phraseological competence in academic English and develop a good working knowledge of discipline-specific formulaic language. This paper aims to explore if SciE-Lex, a powerful lexical database of biomedical research articles, can be exploited by EAL writers to enhance their command of formulaic language in biomedical English published writing. Our paper reports on the challenges associated with formulaic language (namely collocations for EAL writers, it reflects on the benefits of using a lexical database and it evaluates a pedagogical approach to helping EAL writers produce publishable texts. It specifically highlights results from two writing workshops conducted for EAL writers (medical researchers in the present study. The workshops involved medical researchers working on drafts of their writing using SciE-Lex. Our paper reports on the specific benefits of using SciE-Lex as demonstrated by revisions in the writing produced by the EAL medical researchers. This contribution aims to contribute to current discussion on English for Research Publication Purposes (ERPP for the EAL community who now form the main contributors to research knowledge dissemination.

  20. Penerapan Asas Lex Specialis Derogat Legi Generalis dan Penyelesaian Sengketa Ekonomi dalam Undang-Undang Perbankan Syariah di Indonesia

    Directory of Open Access Journals (Sweden)

    Fikri La Hafi

    2017-08-01

    Full Text Available Tulisan ini mengkaji Undang-Undang Republik Indonesia Nomor 23 Tahun 2004 tentang Perubahan atas Undang-Undang Republik Indonesia Nomor 10 Tahun 1998 tentang Bank Indonesia, yang berlaku umum. Sedangkan Undang-Undang Republik Indonesia Nomor 21 Tahun 2008 tentang Perbankan Syariah, berlaku khusus. Penerapan asas lex specialis derogat legi generali menegaskan bahwa Undang-Undang Republik Indonesia Nomor 21 Tahun 2008 memiliki kedudukan lebih kuat dibandingkan Undang-Undang Republik Indonesia Nomor 23 Tahun 2004 yang berlaku umum. Keberlakuan Undang-Undang Republik Indonesia Nomor 21 Tahun 2008 mengokohkan eksistensi perbankan syariah untuk leluasa menjalankan aktivitas dan produk-produknya. Di samping itu, apabila merujuk kepada Undang-Undang Republik Indonesia Nomor 30 Tahun 1999, maka penyelesaian sengketa perbankan syariah dapat ditempuh melalui dua cara yaitu, pengadilan negeri dan badan arbitrase. Namun setelah berlakunya Undang-Undang Republik Indonesia Nomor 21 Tahun 2008 Pasal 55, dengan jelas disebutkan bahwa pengadilan yang berwenang melaksanakan putusan Badan Arbitrase Syariah Nasional (Basyarnas dan menyelesaikan sengketa perbankan syariah adalah pengadilan agama.(This paper reviews the Act of the Republic of Indonesia Number 23/2004 regarding Amendment to the Act Number 10/1998 concerning Indonesia Bank, which is in effect generally. On the other hand, the Act number 21/2008 regarding sharia banking applies more specifically. The application of lex specialis derogat legi generali principle confirms that the Law of the Republic of Indonesia Number 21/2008 has a stronger position than the Law Number 23/2004, which is generally in effect. The enforcement of the Law of the Republic of Indonesia Number 21/2008 affirms the existence of sharia banking to freely run its activities and products. In addition, when referring to the Law of the Republic of Indonesia Number 30/1999, the resolution of Islamic banking disputes can be done through

  1. Comparison of the biological effects of MMS and Me-lex, a minor groove methylating agent: clarifying the role of N3-methyladenine.

    Science.gov (United States)

    Monti, Paola; Foggetti, Giorgia; Menichini, Paola; Inga, Alberto; Gold, Barry; Fronza, Gilberto

    2014-01-01

    N3-methyladenine (3-mA), generated by the reaction of methylating agents with DNA, is considered a highly toxic but weakly mutagenic lesion. However, due to its intrinsic instability, some of the biological effects of the adduct can result from the formation of the corresponding depurination product [an apurinic (AP)-site]. Previously, we exploited Me-lex, i.e. {1-methyl-4-[1-methyl-4-(3-methoxysulfonylpropanamido)pyrrole-2-carboxamido]-pyrrole-2 carboxamido}propane, a minor groove equilibrium binder with selectivity for A/T rich sequences that efficiently reacts with DNA to afford 3-mA as the dominant product, to probe the biology of this lesion. Using human p53 cDNA as a target in a yeast system, a weak increase in mutagenicity was observed in the absence of Mag1 (3-methyladenine-DNA glycosylase 1, mag1), the enzyme devoted to remove 3-mA from DNA. Moreover, a significant increase in mutagenicity occurred in the absence of the enzymes involved in the repair of AP-sites (AP endonucleases 1 and 2, apn1apn2). Since methyl methanesulfonate (MMS) has been extensively used to explore the biological effects of 3-mA, even though it produces 3-mA in low relative yield, we compared the toxicity and mutagenicity induced by MMS and Me-lex in yeast. A mutagenesis reporter plasmid was damaged in vitro by MMS and then transformed into wild-type and Translesion Synthesis (TLS) Polζ (REV3) and Polη (RAD30) deficient strains. Furthermore, a mag1rad30 double mutant strain was constructed and transformed with the DNA plasmid damaged in vitro by Me-lex. The results confirm the important role of Polζ in the mutagenic bypass of MMS and Me-lex induced lesions, with Polη contributing only towards the bypass of Me-lex induced lesions, mainly in an error-free way. Previous and present results point towards the involvement of AP-sites, derived from the depurination of 3-mA, in the observed toxicity and mutagenicity. Copyright © 2013 Elsevier B.V. All rights reserved.

  2. Regulation of the O-glycan-type Sialyl-Lewis X (sLex) Bio-synthesis Pathway during Cell Transformation Programs: Epithelial-Mesenchymal Transition (EMT) and Molecular Subtypes in Breast Carcinoma and Human T Cell Activation

    KAUST Repository

    AbuElela, Ayman

    2017-12-01

    During tumor progression and development of distant metastases, a subset of cancer cells undergoes transformation programs, such as epithelial-mesenchymal transition (EMT), to acquire enhanced migratory attributes to commence the metastatic cascade with the intension of achieving an active cell adhesion molecule-mediated organ-specific homing. Similarly, naive T cells reform the assemblage of their surface adhesion molecules during differentiation to activated T cells in order to successfully home to sites of inflammation and other extra-lymphoid organs for surveillance purposes. Sialyl-Lewis X (sLex) is well-known for mediating the homing of epithelial circulating tumor cellss (CTCs) and activated T cells to target sites through the interaction with endothelial selectins. Since glycan structures are not directly encoded by the genome, their expression is dependent on the glycosyltransferase (GT) expression and activity. Yet, the modulation of GTs during breast cancer transformation and in different molecular subtypes is still unknown. In addition, although the regulation of GTs during T cell activation is well-understood, the regulation at the epigenetic level is lacking. O-glycan-type sLex expression and E-selectin binding under static and flow conditions varies among molecular subtypes of breast cancer and upon the induction of EMT which is linked to the expression patterns of GTs. GTs displayed a significant prognostic value of in the association with the patients\\' survival profiles and in the ability to predict the breast cancer molecular subtypes from the expression data of a random patient sample. Also, GTs were able to differentiate between tumor and their normal counterparts as well as cancer types and glioblastoma subtypes. On the other hand, we studied the regulation of GTs in human CD4+ memory T cells compared to the naive cells at the epigenetic level. Memory T cell subsets demonstrated differential chromatin accessibility and histone marks within

  3. Clinical Outcomes of Small Incision Lenticule Extraction with Accelerated Cross-Linking (ReLEx SMILE Xtra) in Patients with Thin Corneas and Borderline Topography

    OpenAIRE

    Ganesh, Sri; Brar, Sheetal

    2015-01-01

    Purpose. To study the safety and clinical outcomes of ReLEx SMILE with accelerated cross-linking in individuals with thinner corneas, borderline topography, and higher refractive errors. Methods. Eligible patients first underwent SMILE procedure for correction of myopic refractive error. Following the removal of lenticule, 0.25% riboflavin in saline was injected into the interface and allowed to diffuse for 60 seconds. Finally, eye was exposed to UV-A radiation of 45 mW/cm2 for 75 seconds thr...

  4. Le chantier médiéval dans le Sud-Est de la France: regard sur les techniques de construction et l’organisation du chantier à partir de quelques exemples (XIe-XIVe siècles

    Directory of Open Access Journals (Sweden)

    Esquieu, Yves

    2005-12-01

    Full Text Available The present article illustrates several aspects of the archaeological research on mediaeval construction in south-eastern France (11th-14th cent. by studies in building archaeology led by the authors in various architectural and scientific contexts. It focuses on questions such as the know-how and its transfer, changes in the architectural project, the organization of the building process and its techniques and strategies, by analyzing the masonry and structure of the edifice and, in the case of the pope’s palace in Avignon, by combined research on the architecture and the written sources.Le présent article illustre différents aspects de la recherche sur la construction du XIe au XIVe siècle dans le Sud-Est de la France à l’exemple d’études monumentales menées par ses deux auteurs dans différents contextes architecturaux et scientifiques. Il aborde les questions du savoir-faire et de sa transmission, des changements de projet, et l’organisation du chantier, à partir des indices de la lecture des élévations et, dans le cas de la construction du palais des papes d’Avignon, de l’étude conjointe des sources écrites.

  5. Uncorrected and Corrected Distance Visual Acuity, Predictability, Efficacy, and Safety after Femtosecond Laser in Situ Keratomileusis (FS-LASIK) and Refractive Lenticule extraction (ReLEx) for Moderate and High Myopia

    DEFF Research Database (Denmark)

    Vestergaard, Anders; Justesen, Birgitte Larsen; Melsen, Charlotte

    Title: Uncorrected and Corrected Distance Visual Acuity, Predictability, Efficacy, and Safety after Femtosecond Laser in Situ Keratomileusis (FS-LASIK) and Refractive Lenticule extraction (ReLEx) for Moderate and High Myopia. Vestergaard A., Justesen B., Melsen C., Lyhne N., Department of Ophthal......Title: Uncorrected and Corrected Distance Visual Acuity, Predictability, Efficacy, and Safety after Femtosecond Laser in Situ Keratomileusis (FS-LASIK) and Refractive Lenticule extraction (ReLEx) for Moderate and High Myopia. Vestergaard A., Justesen B., Melsen C., Lyhne N., Department...

  6. LA INTERPRETACIÓN JURISPRUDENCIAL EXTENSIVA A LOS VERBOS RECTORES DE LA LEX AQUILIA DE DAMNO The jurisprudential extensive interpretation to the governing verb of the lex Aquilia of damno

    Directory of Open Access Journals (Sweden)

    Cristián Aedo Barrena

    2011-01-01

    Full Text Available El presente artículo asume la premisa, sustentada por la doctrina romanística mayoritaria, de que el delito de damnum, en otros términos, el otorgamiento de la actio directa emanada de la lex Aquilia, suponía cumplir, tanto para el capítulo primero, como para el tercero, el principio corpore corpori, es decir, que se exigía un inmediato contacto físico entre el autor del daño, sobre el cuerpo de la cosa dañada. Desde este punto de vista, el artículo explora los mecanismos de ampliación jurisprudencial de los verbos rectores del capítulo primero y tercero. En relación con el capítulo primero, se analiza el origen, evolución y admisión de la famosa distinción de Celso, entre occidere y causam mortis praestare. Según esta fórmula, siempre que se cumpliese con el principio corpore corpori en el resultado de muerte, procedía el otorgamiento de una acción directa. En cambio, en las hipótesis de omisiones que conducían a un resultado de muerte, que en la fórmula de Celso se traduce en la expresión causam mortis praestare (dar ocasión de muerte, era procedente la acción decretal. El problema es que, como se analiza en el texto, la fórmula fue perfilada recién en el período clásico, con un antecedente en Ofilio y, una vez elaborada por Celso, no fue seguida en todos los casos por juristas contemporáneos o posteriores a él, lo que supone preguntarse las razones que llevaron a algunos juristas a otorgar una acción directa en los casos de conductas omisivas. Finalmente, en relación con el capítulo tercero, el artículo se detiene fundamentalmente en la ampliación desde la interpretación de rumpere por corrumpere, tanto en los casos de causalidad mediata, como en aquellos en los que la cosa no era destruida, pero perdía funcionalidad para el dueño.This article assumes the premise, supported by doctrine Romance majority, that the crime of damnum, in other words, the granting of direct actio issued by the lex Aquilia

  7. L’hégémonie politique et économique comme cadre de diffusion des techniques de construction au Moyen Age: la Corse entre Toscane et Ligurie du XIe au XIVe s.

    Directory of Open Access Journals (Sweden)

    Istria, Daniel

    2005-12-01

    Full Text Available Medieval Corsica is an area where few major architectural constructions have been developing. Nevertheless thanks to its geographical position as well as to the overwhelming political context, it does possess an undeniable importance if we focus on such issues as trade and the transfers of the know-how. Indeed the construction, from the 11th under the control of the archbishop of Pisa, of a considerable network of building devoted to worship, leads to the introduction and consequently to the spread of technical processes engineered in the most renowned building sites on the mainland and more particularly in Tuscany. Corsica is thus experiencing a complete architectural rebirth.La Corse médiévale est une région où peu de réalisations majeures voient le jour dans le domaine de l’architecture. Elle n’en demeure pas moins, compte tenu de sa position et du contexte politique, d’un intérêt certain pour l’étude des échanges et des transferts de savoir-faire. La construction d’un important réseau d’édifices de culte à partir de la fin du XIe siècle sous le contrôle de l’archevêque de Pise, permet l’introduction, puis la diffusion, de procédés techniques élaborés sur les grands chantiers continentaux, particulièrement toscans. C’est alors une véritable renaissance de l’architecture que connaît la Corse.

  8. Lex Virtualis Ipsa Loquitur

    African Journals Online (AJOL)

    Wian Erlank

    Seen in a different way, an avatar is the virtual world personification of you. 36. This virtual world is called Star Trek Online. Other distinct "universes" include those derived from. Star Wars (Star Trek: The Old Republic), Harry Potter (Harry Potter Online) and Lord of the. Rings (The Lord of the Rings Online), amongst others.

  9. Die „lex CEU“: der Tropfen, der das Fass zum Überlaufen bringt? Die ungarische Normsetzung an der Grenze des Rechtsstaates / Zoltán Rónay

    Index Scriptorium Estoniae

    Rónay, Zoltán

    2017-01-01

    Ungari kõrgharidusseaduse ja teiste seaduse muudatustest, mis puudutavad ka Kesk-Euroopa Ülikooli (seaduse hüüdnimi Lex CEU). Selle seaduse vastavusest õigusriigi põhimõtetele. Seaduse tekstid saksa keeles lk. 389-395

  10. Models for Broad Area Event Identification and Yield Estimation: Multiple Coda Types

    Science.gov (United States)

    2011-09-01

    microearthquakes accompanying hydraulic fracturing in granitic rock, Bull. Seism . Soc. Am., 81, 553-575, 1991. Fisk, M. and S. R. Taylor, (2007...146882, pp. 13. Yang, X., T. Lay, X.-B. Xie, and M. S. Thorne (2007). Geometric spreading of Pn and Sn in a spherical Earth model, Bull. Seism . Soc

  11. De la culpa de la lex Aquilia del derecho romano al principio de la responsabilidad por culpa en el derecho civil colombiano

    Directory of Open Access Journals (Sweden)

    Luis Carlos Sánchez

    2016-06-01

    Full Text Available Actualmente se discute la vigencia del principio de la culpa en la responsabilidad civil, especialmente por el surgimiento de la responsabilidad por actividades peligrosas. Este escrito realiza un análisis crítico del concepto de culpa, desde su surgimiento con la interpretación de la lex Aquilia del derecho romano, hasta la moderna comprensión del instituto por la jurisprudencia civil colombiana, pues una adecuada solución a los problemas actuales solo es posible mediante la comprensión de la tradición que antecede a nuestras instituciones; no sólo con la finalidad de reconstruir su historia, sino también de encontrar, dentro de dicha tradición, eventuales fracturas que podrían ser la causa de las actuales problemáticas.

  12. UV induction of the LT-Toxin operon with respect to the genes lexA, recA, and umuD

    International Nuclear Information System (INIS)

    Tiganova, I.G.; Rusina, O.Yu.; Andreeva, I.V.; Brukhanskii, G.V.; Skavronskaya, A.G.

    1994-01-01

    UV induction of the elt operon (the LT-toxin operon in Escherichia coli) was demonstrated in experiments using fusion of elt::lac operons with the help of Mud1(Ap lac) phage. UV induction of the elt operon is lexA-dependent; thus, the possibility of SOS regulation of this process may be assumed. However, UV induction of the elt operon turned out to be recA-independent, which makes it impossible to consider this induction as a typical SOS response. UV induction of the elt operon is also observed in Salmonella typhimurium, which differs from E. coli in the product of umuD, which suggests that the UV induction of the elt operon is umuD independent

  13. LOS REQUISITOS DE LA LEX AQUILIA, CON ESPECIAL REFERENCIA AL DAÑO: LECTURAS DESDE LAS DISTINTAS TEORÍAS SOBRE EL CAPÍTULO TERCERO

    Directory of Open Access Journals (Sweden)

    Cristian Aedo Barrena

    2009-01-01

    Full Text Available El presente trabajo tiene por objeto hacer un breve repaso de los requisitos que la lex Aquilia exigía para su concurrencia, desde las distintas lecturas que la doctrina romanista moderna ha hecho del capítulo tercero. Así, se muestra de que manera las distintas posiciones influyen en la conceptualización de la Murta, en el desarrollo decretal y, por consiguiente en la relación de causalidad, pero especialmente en el daño, que es el requisito al cual la investigación presta más atención. Así se analiza, según estas diferentes visiones, el desarrollo del principio idquod interest. Claramente, como se ha insinuado en este resumen, se enfrentan dos visiones contrapuestas, entre aquellos que ven en la lex Aquilia un estatuto originariamente resarcitorio (negando incluso el principio corpore corpori y adjudicándolo a la interpretación medieval versus un punto de vista que considera que la ley tenía originariamente un carácter estrictamente penal, derivando paulatinamente hacia un carácter resarcitorio. En el primer punto de vista, el principio id quod interest se presentó desde un comienzo en el capítulo tercero, el que exclusivamente se refería al daño (tesis de Daube; desde el segundo punto de vista, la interpretación permitió la evolución desde el premium corporis hasta el principio id quod interest, en el punto de vista afirmado desde Jolowicz y recientemente sustentado por Valditara.This paper aims to make a brief review of the requirements that the lex Aquilia required for its concurrence, from the various readings that the modern Roman law doctrine has made the third chapter. Thus, it shows how the different positions that influence the conceptualization of iniuria, in the development decretal, and therefore in terms of causality, but especially in the damage, which in that part of that research pays more attention. So is analyzed, as these various visions, the development of the principle id quod interest. Clearly, as

  14. AS FONTES DA NOVA LEX MERCATORIA: O início de uma nova alquimia reflexiva -métodos e reflexos; fluxos e impulsos

    Directory of Open Access Journals (Sweden)

    Ricardo Alexandre, CARDOSO RODRIGUES

    2015-12-01

    Full Text Available We have witnessed, in recent years, the multiple manifestations of the New World Order, in the political, social, economic and financial plans. The new lex mercatoria represents the best expression these mutations in Transnational trade, by their transnational nature, dynamic, reveals itself intensely multifaceted, reason why constitutes a legal reality open-ended or in progress.In this study, we intend to develop, scientifically, what it designate be, in the plane of legal sources, the hard nucleus of new law merchant, their various embodiments and developments in the course of history. The fundamental aim of this research is through an systematization process allow jurists and interested in these subjects simplified access for a deep understanding of its nature and extent.

  15. Clinical Outcomes of Small Incision Lenticule Extraction with Accelerated Cross-Linking (ReLEx SMILE Xtra) in Patients with Thin Corneas and Borderline Topography.

    Science.gov (United States)

    Ganesh, Sri; Brar, Sheetal

    2015-01-01

    Purpose. To study the safety and clinical outcomes of ReLEx SMILE with accelerated cross-linking in individuals with thinner corneas, borderline topography, and higher refractive errors. Methods. Eligible patients first underwent SMILE procedure for correction of myopic refractive error. Following the removal of lenticule, 0.25% riboflavin in saline was injected into the interface and allowed to diffuse for 60 seconds. Finally, eye was exposed to UV-A radiation of 45 mW/cm(2) for 75 seconds through the cap. Total energy delivered was 3.4 J/cm(2). Results. 40 eyes of 20 patients with mean age of 26.75 ± 5.99 years were treated. Mean follow-up was 12 months ± 28.12 days. Mean spherical equivalent (SE) was -5.02 ± 2.06 D preoperatively and -0.24 ± 0.18 D postoperatively. The mean central corneal thickness (CCT) and keratometry changed from 501 ± 25.90 µm to 415 ± 42.26 µm and 45.40 ± 1.40 D to 41.2 ± 2.75 D, respectively. Mean uncorrected visual acuity (UCVA) was 20/25 or better in all eyes. No eyes lost lines of corrected distant visual acuity (CDVA). There were no complications like haze, keratitis, ectasia, or regression. Conclusion. Based on the initial clinical outcome it appears that SMILE Xtra may be a safe and feasible modality to prevent corneal ectasia in susceptible individuals.

  16. Clinical Outcomes of Small Incision Lenticule Extraction with Accelerated Cross-Linking (ReLEx SMILE Xtra in Patients with Thin Corneas and Borderline Topography

    Directory of Open Access Journals (Sweden)

    Sri Ganesh

    2015-01-01

    Full Text Available Purpose. To study the safety and clinical outcomes of ReLEx SMILE with accelerated cross-linking in individuals with thinner corneas, borderline topography, and higher refractive errors. Methods. Eligible patients first underwent SMILE procedure for correction of myopic refractive error. Following the removal of lenticule, 0.25% riboflavin in saline was injected into the interface and allowed to diffuse for 60 seconds. Finally, eye was exposed to UV-A radiation of 45 mW/cm2 for 75 seconds through the cap. Total energy delivered was 3.4 J/cm2. Results. 40 eyes of 20 patients with mean age of 26.75 ± 5.99 years were treated. Mean follow-up was 12 months ± 28.12 days. Mean spherical equivalent (SE was −5.02 ± 2.06 D preoperatively and −0.24 ± 0.18 D postoperatively. The mean central corneal thickness (CCT and keratometry changed from 501 ± 25.90 µm to 415 ± 42.26 µm and 45.40 ± 1.40 D to 41.2 ± 2.75 D, respectively. Mean uncorrected visual acuity (UCVA was 20/25 or better in all eyes. No eyes lost lines of corrected distant visual acuity (CDVA. There were no complications like haze, keratitis, ectasia, or regression. Conclusion. Based on the initial clinical outcome it appears that SMILE Xtra may be a safe and feasible modality to prevent corneal ectasia in susceptible individuals.

  17. Comparison of ReLEx SMILE and PRK in terms of visual and refractive outcomes for the correction of low myopia.

    Science.gov (United States)

    Ganesh, Sri; Brar, Sheetal; Patel, Utsav

    2017-05-27

    To compare the objective and subjective quality of vision after femtosecond laser-assisted small incision lenticule extraction (SMILE) and photorefractive keratectomy (PRK) for low myopia. One hundred and twenty eyes from 60 patients (34 females, 26 males) undergoing bilateral correction of low myopia (≤-4 D SE) with either ReLEx SMILE or PRK were included. Visual acuity, contrast sensitivity and higher-order aberrations were recorded preoperatively and compared postoperatively. A quality of vision questionnaire was scored and analyzed 3 months postoperatively. At 3 months, the SMILE group had significantly better uncorrected and corrected distant visual acuity (CDVA), compared to PRK group (p = 0.01). Post-op spherical equivalent (SE) was comparable in both groups (SMILE = -0.15 ± 0.19 D, PRK = -0.14 ± 0.23 D, p = 0.72). However, SE predictability was better in SMILE group with 97% eyes within ±0.05 D compared to 93% eyes in the PRK group. Total higher-order aberrations (HOAs) were significantly higher in PRK compared to the SMILE group (p = 0.022). The SMILE group demonstrated slightly better contrast sensitivity, which was significant at spatial frequency of 12 cpd (p = 0.03). Four eyes in the PRK group had loss of CDVA by one line due to mild haze. Both SMILE and PRK were effective procedures for correction of low myopia. However, SMILE offered superior quality of vision and patient satisfaction due to better postoperative comfort and lower induction of aberrations at 3 months.

  18. Imunodiagnóstico da cisticercose em suíno experimentalmente infectado com ovos de Taenia solium, utilizando antígeno de escólex de Cysticercus cellulosae

    OpenAIRE

    Soares,K.A.; Silva,M.R.M.; Poleti,M.D.; Maia,A.A.M.

    2006-01-01

    Colheu-se sangue de sete suínos infectados com ovos de Taenia solium, semanalmente, durante 140 dias, para realizar ELISA no soro, utilizando antígeno de escólex (Es-Tso) de C. cellulosae. Em todos os animais, após o 21º dia pós-infecção, houve incremento significativo de anticorpos IgG, que assim se mantiveram até o final do experimento. A sensibilidade do ELISA variou entre 87,5 e 100%. À necropsia, foram identificados 238 cisticercos. Seis suínos apresentaram pelo menos um cisto no coração...

  19. Memorandum k návrhu na rozšíření působnosti zákona tzv. lex Perek při přípravě národnostního statutu

    Czech Academy of Sciences Publication Activity Database

    Sulitka, Andrej

    2016-01-01

    Roč. 62, č. 1 (2016), s. 145-160 ISSN 0323-0619 Institutional support: RVO:68378076 Keywords : National Statute (1938) * Lex Perek * Memorandum of the Silesian League for the Raising of Public Awareness and of the League of Opava (1938) * refusal of Lex Perek for the territory of the former Land of Silesia * Polish demands in the field of education * refusing attitude of the Ministry of Education * National Awareness of the Czechoslovak Republic towards the Polish demands Subject RIV: AC - Archeology, Anthropology, Ethnology

  20. Lexías utilizadas por los estudiantes de noveno año del período lectivo 2009 del Instituto de Educación Integral para referirse a personas homosexuales

    Directory of Open Access Journals (Sweden)

    Ronald Campos López

    2010-01-01

    Full Text Available Se identifican las lexías utilizadas para referirse a las personas homosexuales por los estudiantes de noveno del período lectivo 2009 del Instituto de Educación Integral de Las Nubes, Coronado, Costa Rica; esto con el fin de determinar la frecuencia de uso, situaciones comunicativas y carácter semántico de estas palabras, según la conceptualización constructivista de esta retícula social cerrada (los adolescentes. A partir de estos datos, se analiza el nivel ideológico de aceptación y rechazo de estos jóvenes hacia la comunidad homosexual en general. Al final, se brindan criterios y recomendaciones a los docentes para el aprovechamiento y discusión sobre el uso de estas palabras en el aula.

  1. Resistance to nitrofurantoin and UV-irradiation in recA; uvrA; and uvrA, lexA, Escherichia coli mutants conferred by an R-plasmid from an Escherichia coli clinical isolate

    International Nuclear Information System (INIS)

    Obaseiki-Ebor, E.E.

    1984-01-01

    There have been some reports of R-plasmids conferring nitrofuran resistance by decreasing the reduction of nitrofurantoin. The mechanism by which these R-plasmids mediate nitrofurantoin resistance is still not properly understood. Since DNA repair mutants are very sensitive to nitrofurantoin, it was therefore of interest to see whether R-plasmids conferring nitrofurantoin resistance affected the nitrofurantoin sensitivity of recA; uvrA and uvrA, lexA strains of E. coli K-12. Protection against UV-irradiation was also estimated. The experiments showed that the nitrofurantoin resistance conferred by R-plasmid pBN105 was not due to defective nitrofurantoin reduction or altered permeability of the cell. Because it is known that repair-deficient bacteria have increased susceptibility to nitrofurantoin, it may be suggested that the mechanisms of UV and nitrofurantoin protection conferred by pBN105 to the DNA repair mutant strains are related. (Auth.)

  2. El juego de las normas imperativas en el Reglamento Roma II sobre ley aplicable a las obligaciones no contractuales: límites a la aplicación de la lex causae

    Directory of Open Access Journals (Sweden)

    Javier Maseda Rodríguez

    2013-06-01

    Full Text Available This work analyzes the relevance of the mandatory provisions in the field of the law applicable to non contractual obligations of the Rome II Regulation. On the one hand, the lois de police or overriding mandatory provisions of the forum, of a foreign law and of the proper lex causae, once the selection of the governing applicable law through freedom of choice rules or through those rules applicable in default of agreement. And, on the other hand, the relevance of domestic and EU provisions which cannot be derogated from by agreement under the agreement between the person claimed to be liable and the person who has sustained damage to submit non-contractual obligations to the law of their choice.

  3. An improved experimental model for peripheral neuropathy in rats

    Energy Technology Data Exchange (ETDEWEB)

    Dias, Q.M.; Rossaneis, A.C.; Fais, R.S.; Prado, W.A. [Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil)

    2013-03-15

    A modification of the Bennett and Xie chronic constriction injury model of peripheral painful neuropathy was developed in rats. Under tribromoethanol anesthesia, a single ligature with 100% cotton glace thread was placed around the right sciatic nerve proximal to its trifurcation. The change in the hind paw reflex threshold after mechanical stimulation observed with this modified model was compared to the change in threshold observed in rats subjected to the Bennett and Xie or the Kim and Chung spinal ligation models. The mechanical threshold was measured with an automated electronic von Frey apparatus 0, 2, 7, and 14 days after surgery, and this threshold was compared to that measured in sham rats. All injury models produced significant hyperalgesia in the operated hind limb. The modified model produced mean ± SD thresholds in g (19.98 ± 3.08, 14.98 ± 1.86, and 13.80 ± 1.00 at 2, 7, and 14 days after surgery, respectively) similar to those obtained with the spinal ligation model (20.03 ± 1.99, 13.46 ± 2.55, and 12.46 ± 2.38 at 2, 7, and 14 days after surgery, respectively), but less variable when compared to the Bennett and Xie model (21.20 ± 8.06, 18.61 ± 7.69, and 18.76 ± 6.46 at 2, 7, and 14 days after surgery, respectively). The modified method required less surgical skill than the spinal nerve ligation model.

  4. An improved experimental model for peripheral neuropathy in rats

    Directory of Open Access Journals (Sweden)

    Q.M. Dias

    Full Text Available A modification of the Bennett and Xie chronic constriction injury model of peripheral painful neuropathy was developed in rats. Under tribromoethanol anesthesia, a single ligature with 100% cotton glace thread was placed around the right sciatic nerve proximal to its trifurcation. The change in the hind paw reflex threshold after mechanical stimulation observed with this modified model was compared to the change in threshold observed in rats subjected to the Bennett and Xie or the Kim and Chung spinal ligation models. The mechanical threshold was measured with an automated electronic von Frey apparatus 0, 2, 7, and 14 days after surgery, and this threshold was compared to that measured in sham rats. All injury models produced significant hyperalgesia in the operated hind limb. The modified model produced mean ± SD thresholds in g (19.98 ± 3.08, 14.98 ± 1.86, and 13.80 ± 1.00 at 2, 7, and 14 days after surgery, respectively similar to those obtained with the spinal ligation model (20.03 ± 1.99, 13.46 ± 2.55, and 12.46 ± 2.38 at 2, 7, and 14 days after surgery, respectively, but less variable when compared to the Bennett and Xie model (21.20 ± 8.06, 18.61 ± 7.69, and 18.76 ± 6.46 at 2, 7, and 14 days after surgery, respectively. The modified method required less surgical skill than the spinal nerve ligation model.

  5. Hawking Temperature of Acoustic Black Hole Zhi Kun Xie

    Indian Academy of Sciences (India)

    Abstract. Using a new tortoise coordinate transformation, the Hawking radiation of the acoustic black hole was discussed by studying the Klein–. Gordon equation of scalar particles in the curve space-time. It was found that the Hawking temperature is connected with time and position on the event horizon. Key words.

  6. La gestión social del sílex melado durante el Neolítico medio en el nordeste de la Península Ibérica

    Directory of Open Access Journals (Sweden)

    Terradas, Xavier

    2002-06-01

    Full Text Available Not Available.

    [es] En este artículo presentamos la reconstrucción de las estrategias desarrolladas en la gestión de un recurso mineral concreto, el sílex melado presumiblemente procedente del valle del Ródano, por los grupos humanos que durante el Neolítico medio habitaron el nordeste peninsular. A partir de los restos líticos recuperados en varios yacimientos catalanes constatamos una fragmentación en el tiempo y el espacio de los procedimientos técnicos aplicados en la explotación de esta materia prima de origen lejano, orientada hacia la generación de una mayor rentabilidad de las actividades económicas desarrolladas. Sin embargo, esta rentabilidad entra en contradicción con el fin al que fueron destinados una gran parte de los productos obtenidos, como elementos de ajuaren inhumaciones individuales conocidas como sepulcros de fosa, al tratarse de productos no utilizados o todavía operativos desde un punto de vista funcional. [fr] La gestion sociale du silex blond durant le Néolithique Moyen au Nord-Est de la Péninsule Ibérique. Nous présentons ici la reconstruction des stratégies mises en œuvre dans la gestion d'un ressource minéral concret, le silex blond présumablement procédant de la vallée du Rhône, par les groupes humaines que pendant le Néolithique moyen habitèrent le nord-est de la Péninsule ibérique. A partir des vestiges lithiques récupérés dans plusieurs sites catalanes on constate une fragmentation dans le temps et l'espace des procédés techniques mises en œuvre par l'exploitation de cette matière première d'origine lointaine, dirigée vers l'obtention d'une plus grande rentabilité des activités économiques. Néanmoins, cette rentabilité est en contradiction avec la destination d'une grande partie des produits obtenus, encore opératifs du point de vue fonctionnel ou pas utilisés, vers des inhumations individuelles connues comme sépulcres de fosse.

  7. Study on the treatment effect of Bx decoction on rat models of reflux esophagitis

    International Nuclear Information System (INIS)

    Liu Xiaoni; Jin Xiudong; Li Yuezhen; Liu Guilian; Sun Wei

    2008-01-01

    Objective: To explore the mechanism of BAN-XIA-XIE-XIN Decoction (Bx Decoction) treatment in rat models of reflux esophagitis. Methods: Rat models of reflux esophagitis were prepared with the method previously reported from this laboratory. Twenty-five models each were left untreated, treated with cisapride (2.5 mg/kg/d) or treated with BAN-XIA-XIE-XIN Decoction (BX) 5.78m/kg/d) respectively. All the models were sacrificed after 4 weeks, acid contents in gastric juice, cholic acid contents in duodenal juice as well as calcitonin-gene-related peptide (CGRP) (with RIA) contents in lower esophageal tissue and plasma were measured. Histologic examination of lower esophageal tissue for degree of esophagitis was also performed in all the models. Besides, 25 animals underwent sham operation only and served as controls. Results: The positive rates of pathologic changes (mucosal inflammation, squamous cell hyperplasia, lamina propria extension and mucosal erosion) were all significantly higher in the non-treated models than those in the BX treated models (P<0.01). Acid contents in gastric juice were significantly lowered with pH significantly increased in the BX treated group (P<0.01). The CGRP contents in esophageal tissue in the BX treated models, though remains lower than those in the 25 animals with sham operation only, were significantly higher than those in non-treated models (P<0.01). The plasma contents of CGRP in the BX-treated models remained significantly higher than those in sham-operation animals (P<0.01), decrease from the very high levels in untreated model was not large enough to be significant. Conclusion: BX-decoction might exert its protective effect on esophageal mucosa through lowering of gastric acidity with modulation of CGRP synthesis. (authors)

  8. LOS DELITOS DE VIOLACIÓN Y ESTUPRO DEL ARTÍCULO 365 BIS CÓDIGO PENAL: UNA RACIONALIZACIÓN DESDE EL MANDATO DE LEX STRICTA Y EL PRINCIPIO DE LESIVIDAD. ESPECIAL REFERENCIA A LA INTRODUCCIÓN DE DEDOS U OTRAS PARTES DEL CUERPO

    Directory of Open Access Journals (Sweden)

    José Ángel Fernández Cruz

    2007-01-01

    Full Text Available El art. 365 bis CP constituye una de las últimas manifestaciones del modelo penal de seguridad ciudadana en nuestro Sistema Penal que, en esta ocasión, ha tenido como principales víctimas a los principios de legalidad y correspondencia con la realidad social. El desconocimiento de la realidad social por parte del legislador penal a la hora de describir el precepto in comento ha ocasionado una falta de certeza jurídica que, a la vez, ha derivado en una quiebra del mandato de ¡ex stricta por parte de la mayoría de los tribunales penales chilenos. El presente artículo pretende, en la medida de lo posible, mitigar la manifiesta irracionalidad de este precepto a través de una interpretación alternativa desde el mandado de ¡ex stricta y el principio de lesividadSection 365 bis of the Chilean Criminal Code is one of the latest manifestations of the law and order policy in our Criminal Justice System. In this occasion, it has mainly affected the principle of legality and its correspondence with social reality. A criminal justice lawmaker non-familiarized with social reality can create a lack of legal certainty and, consequently, a breach of the lex stricta mandate. A paradigmaticlesample of this is the typical description made of section 365 bis and its interpretation by most criminal courts. This paper seeks, to thelestent possible, to mitigate such manifest irrationality

  9. Public Library Training Program for Older Adults Addresses Their Computer and Health Literacy Needs. A Review of: Xie, B. (2011. Improving older adults’ e-health literacy through computer training using NIH online resources. Library & Information Science Research, 34, 63-71. doi: /10.1016/j.lisr.2011.07.006

    Directory of Open Access Journals (Sweden)

    Cari Merkley

    2012-12-01

    – Participants showed significant decreases in their levels of computer anxiety, and significant increases in their interest in computers at the end of the program (p>0.01. Computer and web knowledge also increased among those completing the knowledge tests. Most participants (78% indicated that something they had learned in the program impacted their health decision making, and just over half of respondents (55% changed how they took medication as a result of the program. Participants were also very satisfied with the program’s delivery and format, with 97% indicating that they had learned a lot from the course. Most (68% participants said that they wished the class had been longer, and there was full support for similar programming to be offered at public libraries. Participants also reported that they found the NIHSeniorHealth website more useful, but not significantly more usable, than MedlinePlus.Conclusion – The intervention as designed successfully addressed issues of computer and health literacy with older adult participants. By using existing resources, such as public library computer facilities and curricula developed by the National Institutes of Health, the intervention also provides a model that could be easily replicated in other locations without the need for significant financial resources.

  10. Imunodiagnóstico da cisticercose em suíno experimentalmente infectado com ovos de Taenia solium, utilizando antígeno de escólex de Cysticercus cellulosae Immunodiagnosis of cysticercosis in swine experimentally infected with Taenia solium eggs, using antigen of Cysticercus cellulosae scolex

    Directory of Open Access Journals (Sweden)

    K.A. Soares

    2006-02-01

    Full Text Available Colheu-se sangue de sete suínos infectados com ovos de Taenia solium, semanalmente, durante 140 dias, para realizar ELISA no soro, utilizando antígeno de escólex (Es-Tso de C. cellulosae. Em todos os animais, após o 21º dia pós-infecção, houve incremento significativo de anticorpos IgG, que assim se mantiveram até o final do experimento. A sensibilidade do ELISA variou entre 87,5 e 100%. À necropsia, foram identificados 238 cisticercos. Seis suínos apresentaram pelo menos um cisto no coração, língua ou masseter. Não se observou correlação entre concentração de anticorpos e número de cisticercos identificados.Blood samples from seven swines infected with eggs of Taenia solium, were collected weekly during a period of 140 days. The ELISA was carried out in serum, using antigen from Cysticercus cellulosae scolex (Es-Tso. The antibody levels for all animals significantly increased and maintained constant from the 21th day post-infection to the end of the experiment. The sensitivity of the ELISA test averaged between 87.5% and 100%. At the necropsy, 238 cysticerci were identified. Six swines presented at least one cysticercus in one of the organs: heart, tongue or masseter. No correlation between concentration of antibodies and number of identified cysticerci at necropsy, was observed.

  11. Xie et al., Afr J Tradit Complement Altern Med. (2013) 10(6):542-546 ...

    African Journals Online (AJOL)

    AJTCAM

    have been few. This paper mainly focused on the anti-cancer activity and cell cycle, and cell morphology analysis of L. C.H extracts. Materials and Methods ... Heng Qin equipment, Co., Ltd.), Clean Bench (100 Code Equipment Co., Ltd.), drain the incubator (Shanghai Yuejin Medical Apparatus Factory), and Micropipettes ...

  12. Therapeutic effect of He-Wei-Tong-Xie decoction on acute ...

    African Journals Online (AJOL)

    All patients were evaluated at baseline, and thereafter subjected to standard therapeutic protocols, including, fasting, gastrointestinal decompression, administration of somatostatin and omeprazole. The patients in the treatment group also received 100 mL of HWTX by nasal route with high enema (three times/day).

  13. Lex-Partitioning: A New Option for BDD Search

    Directory of Open Access Journals (Sweden)

    Stefan Edelkamp

    2012-10-01

    Full Text Available For the exploration of large state spaces, symbolic search using binary decision diagrams (BDDs can save huge amounts of memory and computation time. State sets are represented and modified by accessing and manipulating their characteristic functions. BDD partitioning is used to compute the image as the disjunction of smaller subimages. In this paper, we propose a novel BDD partitioning option. The partitioning is lexicographical in the binary representation of the states contained in the set that is represented by a BDD and uniform with respect to the number of states represented. The motivation of controlling the state set sizes in the partitioning is to eventually bridge the gap between explicit and symbolic search. Let n be the size of the binary state vector. We propose an O(n ranking and unranking scheme that supports negated edges and operates on top of precomputed satcount values. For the uniform split of a BDD, we then use unranking to provide paths along which we partition the BDDs. In a shared BDD representation the efforts are O(n. The algorithms are fully integrated in the CUDD library and evaluated in strongly solving general game playing benchmarks.

  14. MetaLex XML and the legal knowledge interchange format

    NARCIS (Netherlands)

    Boer, A.; Winkels, R.; Vitali, F.; Sartor, G.; Casanovas, P.; Casellas, N; Robino, R

    2008-01-01

    Electronic government invariably involves XML and electronic law: legislation is as essential to public administration as the ball is to a ball game. This paper gives an overview of two XML standard proposals dealing with two complementary aspects of electronic legislation - the documents themselves

  15. Introduction to virtual property: Lex virtualis ipsa loquitur | Erlank ...

    African Journals Online (AJOL)

    ... as a point of reference leading to an understanding of the concept of virtual property in general. Keywords: virtual property; virtual worlds; intangible property; intangible objects; objects of property law; property law; Second Life; Facebook; World of Warcraft; immersion; virtual reality; virtual property theft; intangible property ...

  16. Lex genetica: the law and ethics of programming biological code.

    Science.gov (United States)

    Burk, Dan L

    2002-01-01

    Recent advances in genetic engineering now allow the design of programmable biological artifacts. Such programming may include usage constraints that will alter the balance of ownership and control for biotechnology products. Similar changes have been analyzed in the context of digital content management systems, and while this previous work is useful in analyzing issues related to biological programming, the latter technology presents new conceptual problems that require more comprehensive evaluation of the interplay between law and technologically embedded values. In particular, the ability to embed contractual terms in technological artifacts now requires a re-examination of disclosure and consent in transactions involving such artifacts.

  17. Introduction to Virtual Property: Lex Virtualis Ipsa Loquitur

    Directory of Open Access Journals (Sweden)

    Wian Erlank

    2015-12-01

    Full Text Available This article serves as an introduction to the concept of virtual property and also to very briefly note the relevance of virtual property in modern society. A universally accepted definition of virtual property is hard to come by, but the paper will aim to provide some clarity on the issue. Virtual property is still property, and it still exists even though it is intangible. It includes (amongst other things website addresses and email addresses as well as certain other accepted immaterial property objects such as bank accounts, stocks, options and derivatives. Indeed, one can go so far as to include digital goods, such as digital versions of books (e-books, computer or smartphone programmes or apps, television series and movies as well as digital music (albums and tracks as objects of virtual property. However, the focus in this paper is on the type of virtual property found inside virtual worlds. The discussion of virtual property will be facilitated by reference to some of the ancillary and more complicated areas of the field to serve as a point of reference leading to an understanding of the concept of virtual property in general.

  18. Lex alterius: Using Law to Construct Confessional Boundaries

    OpenAIRE

    Tolan , John

    2014-01-01

    Historians and anthropologists are confronted with a persistent problem for which there is no clear solution: the conceptual tools which we use to attempt to understand cultures are themselves products of (often) the very cultures we are attempting to understand. Take "religion". Daniel Boyarin (2004) has argued that the very concept of "religion" as we know it was a product of the fourth and fifth centuries, as bishops and emperors constructed Christianity as a religion (the true one, of cou...

  19. A Multiscale Modeling System: Developments, Applications, and Critical Issues

    Science.gov (United States)

    Tao, Wei-Kuo; Lau, William; Simpson, Joanne; Chern, Jiun-Dar; Atlas, Robert; Khairoutdinov, David Randall Marat; Li, Jui-Lin; Waliser, Duane E.; Jiang, Jonathan; Hou, Arthur; hide

    2009-01-01

    The foremost challenge in parameterizing convective clouds and cloud systems in large-scale models are the many coupled dynamical and physical processes that interact over a wide range of scales, from microphysical scales to the synoptic and planetary scales. This makes the comprehension and representation of convective clouds and cloud systems one of the most complex scientific problems in Earth science. During the past decade, the Global Energy and Water Cycle Experiment (GEWEX) Cloud System Study (GCSS) has pioneered the use of single-column models (SCMs) and cloud-resolving models (CRMs) for the evaluation of the cloud and radiation parameterizations in general circulation models (GCMs; e.g., GEWEX Cloud System Science Team 1993). These activities have uncovered many systematic biases in the radiation, cloud and convection parameterizations of GCMs and have led to the development of new schemes (e.g., Zhang 2002; Pincus et al, 2003; Zhang and Wu 2003; Wu et al. 2003; Liang and Wu 2005; Wu and Liang 2005, and others). Comparisons between SCMs and CRMs using the same large-scale forcing derived from field campaigns have demonstrated that CRMs are superior to SCMs in the prediction of temperature and moisture tendencies (e.g., Das et al. 1999; Randall et al 2003b; Xie et al. 2005).

  20. Analytical modelling of resistive wall mode stabilization by rotation in toroidal tokamak plasmas

    International Nuclear Information System (INIS)

    Ham, C J; Gimblett, C G; Hastie, R J

    2011-01-01

    Stabilization of the resitive wall mode (RWM) may allow fusion power to be doubled for a given magnetic field in advanced tokamak operation. Experimental evidence from DIII-D and other machines suggests that plasma rotation can stabilize the RWM. Several authors (Finn 1995 Phys. Plasmas 2 3782, Bondeson and Xie 1997 Phys. Plasmas 4 2081) have constructed analytical cylindrical models for the RWM, but these do not deal with toroidal effects. The framework of Connor et al (1988 Phys. Fluids 31 577) is used to develop ideal plasma analytic models with toroidicity included. Stepped pressure profiles and careful ordering of terms are used to simplify the analysis. First, a current driven kink mode model is developed and a dispersion relation for arbitrary current profile is calculated. Second, the external pressure driven kink mode is similarly investigated as the most important RWM arises from this mode. Using this latter model it is found that the RWM is stabilized by Alfven continuum damping with rotation levels similar to those seen in experiments. An expression for the stability of the external kink mode for more general current profiles and a resistive wall is derived in the appendix.

  1. On the Use of Generalized Volume Scattering Models for the Improvement of General Polarimetric Model-Based Decomposition

    Directory of Open Access Journals (Sweden)

    Qinghua Xie

    2017-01-01

    Full Text Available Recently, a general polarimetric model-based decomposition framework was proposed by Chen et al., which addresses several well-known limitations in previous decomposition methods and implements a simultaneous full-parameter inversion by using complete polarimetric information. However, it only employs four typical models to characterize the volume scattering component, which limits the parameter inversion performance. To overcome this issue, this paper presents two general polarimetric model-based decomposition methods by incorporating the generalized volume scattering model (GVSM or simplified adaptive volume scattering model, (SAVSM proposed by Antropov et al. and Huang et al., respectively, into the general decomposition framework proposed by Chen et al. By doing so, the final volume coherency matrix structure is selected from a wide range of volume scattering models within a continuous interval according to the data itself without adding unknowns. Moreover, the new approaches rely on one nonlinear optimization stage instead of four as in the previous method proposed by Chen et al. In addition, the parameter inversion procedure adopts the modified algorithm proposed by Xie et al. which leads to higher accuracy and more physically reliable output parameters. A number of Monte Carlo simulations of polarimetric synthetic aperture radar (PolSAR data are carried out and show that the proposed method with GVSM yields an overall improvement in the final accuracy of estimated parameters and outperforms both the version using SAVSM and the original approach. In addition, C-band Radarsat-2 and L-band AIRSAR fully polarimetric images over the San Francisco region are also used for testing purposes. A detailed comparison and analysis of decomposition results over different land-cover types are conducted. According to this study, the use of general decomposition models leads to a more accurate quantitative retrieval of target parameters. However, there

  2. Resenha de: L'Islam dans da première grandeur (VIIIe-XIe siècle

    Directory of Open Access Journals (Sweden)

    Eurípedes Simões de Paula

    2017-04-01

    Full Text Available LOMBARD (Maurice . — L'Islam dans sa première grandeur (VIlle-Xle siècle. Coleção "Nouvelle Bibliothèque Scientique" dirigida por Fernand Braudel. Paris. Flammarion. 1971. 245 pp. 30 cartas e quadros. Preço: 36 F.

  3. Les chants des oiseaux. Musiques, pratiques sociales et représentations du XIe au XVIIIe siècle.

    Directory of Open Access Journals (Sweden)

    Corinne Beck

    2007-10-01

    Full Text Available Le thème du chant des oiseaux a particulièrement été bien traité par les musicologues. L’objectif de ce projet consiste à reprendre cette thématique en l’élargissant à d’autres disciplines a priori éloignées, dont les problématiques centrales touchent essentiellement aux notions de nature, de langage et de mémoire. Jamais encore un projet autour d’un thème aussi étendu n’a été réalisé. L’ambition de ces rencontres interdisciplinaires et internationales vise alors à réunir les nombreux cherche...

  4. Accuracy Assessment of Global Barotropic Ocean Tide Models

    Science.gov (United States)

    2014-08-07

    improved global tidal atlases but also a much deeper insight into the dynamics of global tides. Our understanding of energy dissipation, the role of...Atmospheric Prediction System [Rosmond et al., 2002] atmospheric forcing with wind speeds scaled to be consistent with QuikSCAT [e.g., Liu and Xie, 2006

  5. Modelling

    CERN Document Server

    Spädtke, P

    2013-01-01

    Modeling of technical machines became a standard technique since computer became powerful enough to handle the amount of data relevant to the specific system. Simulation of an existing physical device requires the knowledge of all relevant quantities. Electric fields given by the surrounding boundary as well as magnetic fields caused by coils or permanent magnets have to be known. Internal sources for both fields are sometimes taken into account, such as space charge forces or the internal magnetic field of a moving bunch of charged particles. Used solver routines are briefly described and some bench-marking is shown to estimate necessary computing times for different problems. Different types of charged particle sources will be shown together with a suitable model to describe the physical model. Electron guns are covered as well as different ion sources (volume ion sources, laser ion sources, Penning ion sources, electron resonance ion sources, and H$^-$-sources) together with some remarks on beam transport.

  6. Land Use/Land Cover Change Modeling and the Prediction of Subsequent Changes in Ecosystem Service Values in a Coastal Area of China, the Su-Xi-Chang Region

    Directory of Open Access Journals (Sweden)

    Eshetu Yirsaw

    2017-07-01

    Full Text Available Monitoring the impact of current Land Use/Land Cover (LULC management practices on future Ecosystem Services (ESs provisioning has been emphasized because of the effect of such practices on ecological sustainability. We sought to model and predict the impacts of future LULC changes on subsequent changes in Ecosystem Service Value (ESV in fragile environments undergoing complex LULC changes, Su-Xi-Chang region. After mapping and classifying the LULC for the years 1990, 2000, and 2010 using GIS and remote sensing, a Cellular Automata (CA–Markov model was employed to model future LULC changes for the year 2020. ESV was predicted using the projected LULC data and the modified ES coefficients adopted by Xie et al. (2003. The projected results of the changes in LULC reveal that construction land expanded extensively, mainly at the expense of farmland, wetland, and water bodies. The predicted results of the ESVs indicate that water bodies and farmland are the dominant LULC categories, accounting for 90% of the total ESV. Over the study period, ESVs were diminished by 7.3915 billion CNY, mostly because of the decrease in farmland, water bodies, and wetland. A reasonable land use plan should be developed with an emphasis on controlling construction land encroachment on farmland, wetlands, and water bodies. The rules of ecological protection should be followed in LULC management to preserve ecological resources.

  7. Erratum to: Boson bound states in the β-Fermi–Pasta–Ulam model

    Indian Academy of Sciences (India)

    XIN-GUANG HU1, JU XIANG2,∗. , ZHENG JIAO1, YANG LIU3,. GUO-QIU XIE1 and KE HU4. 1Department of Physics, Huangshan University, Huangshan 245041, Anhui, China. 2Department of Basic Sciences, The First Aeronautical Institute of the Air Force, Xinyang 464000,. Henan, China. 3Department of Basis, Air Force ...

  8. Erratum to: Boson bound states in the β-Fermi–Pasta–Ulam model

    Indian Academy of Sciences (India)

    2014-01-11

    Jan 11, 2014 ... Xin-Guang Hu1 Ju Xiang2 Zheng Jiao1 Yang Liu3 Guo-Qiu Xie1 Ke Hu4. Department of Physics, Huangshan University, Huangshan 245041, Anhui, China; Department of Basic Sciences, The First Aeronautical Institute of the Air Force, Xinyang 464000, Henan, China; Department of Basis, Air Force Early ...

  9. Boson bound states in the β-Fermi–Pasta–Ulam model

    Indian Academy of Sciences (India)

    Xin-Guang Hu1 Ju Xiang2 Zheng Jiao1 Yang Liu3 Guo-Qiu Xie1 Ke Hu3. Department of Physics, Huangshan University, Huangshan 245041, Anhui, China; Department of Basic Sciences, The First Aeronautical Institute of the Air Force, Xinyang 464000, Henan, China; Department of Physics, Xiangtan University, Xiangtan ...

  10. Lex mercatoria---una herramienta flexible para cubrir las necesidades legales del comercio internacional.

    Directory of Open Access Journals (Sweden)

    Jorge Jaramillo Vargas

    2002-01-01

    Full Text Available Después de un periodo de investigación de dos meses en la UNIDROIT, el autor nos presenta un reporte en el que se exploran algunas consideraciones teóricas acerca de las dicotomías que pueden afectar a un Estado en proceso de globalización como son nacional/a-nacional, público/privado, regulación/anti-regulación. La seriedad de sus observaciones así como la amplia bibliografía utilizada, garantizan la calidad del presente escrito.

  11. Perspectives on halogen bonding and other sigma-hole interactions: Lex parsimoniae (Occam's Razor)

    Czech Academy of Sciences Publication Activity Database

    Politzer, P.; Riley, Kevin Eugene; Bulat, F. A.; Murray, J. S.

    2012-01-01

    Roč. 998, SI (2012), s. 2-8 ISSN 2210-271X Institutional research plan: CEZ:AV0Z40550506 Keywords : halogen bonding * alpha-Hole bonding * hydrogen bonding * electrostatics /polarization * dispersion * electrostatic potentials Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.139, year: 2012

  12. Introducing LexTALE: A quick and valid Lexical Test for Advanced Learners of English

    NARCIS (Netherlands)

    Lemhöfer, K.M.L.; Broersma, M.

    2012-01-01

    The increasing number of experimental studies on second language (L2) processing, frequently with English as the L2, calls for a practical and valid measure of English vocabulary knowledge and proficiency. In a large-scale study with Dutch and Korean speakers of L2 English, we tested whether

  13. Climate Justice: A Constitutional Approach to Unify the Lex Specialis Principles of International Climate Law

    NARCIS (Netherlands)

    Thorp, Teresa

    2012-01-01

    Legal principles legitimise ubiquitous social values. They make certain social norms lawful and legitimate. Legal principles may act as governing vectors. They may give effect to a unified and legitimate constitutional framework insofar as a constitution unifies the fundamental principles on which a

  14. Global cultural governance by Investment Arbitral Tribunals:the making of a Lex Administrativa Culturalis

    OpenAIRE

    Vadi, Valentina

    2015-01-01

    The protection of cultural heritage is a fundamental public interest, closely connected to fundamental human rights and deemed to be among the best guarantees of international peace and security. Economic globalization has spurred a more intense dialogue and interaction among nations, potentially promoting cultural diversity. However, this phenomenon may also jeopardize cultural heritage. Foreign direct investments in the extraction of natural resources have the ultimate capacity to change cu...

  15. Erakõrgkool Lex peab uksed kinni panema / Anneli Aasmäe

    Index Scriptorium Estoniae

    Aasmäe, Anneli, 1973-

    2004-01-01

    Tänavu kevadel Lexi kontrollinud järelevalveametnikud tuvastasid koolis rea puudusi: õpperuumid, raamatukogu ja õppejõudude kvalifikatsioon ei vastanud nõuetele, suur osa tudengitega sõlmitud lepingutest olid puudulikud või puudusid üldse jpm

  16. H:\\USERS\\lex12\\skyf\\LVSA kongresreferaat (Lexikos)1

    African Journals Online (AJOL)

    Riette Ruthven

    Lemmata in a Dutch–Afrikaans Translation Dictionary. Voor Pampus liggen has acquired a metaphorical meaning and idiomatic status in Dutch, but is generally unknown to the. Afrikaans lexicographer outside the Dutch context. For the Afrikaans lexicographer with his unique frame of reference and cultural and social value ...

  17. Sources of bioethics: Lex Naturae versus Sola Scriptura and Sola Gratia? A response to Vorster

    Directory of Open Access Journals (Sweden)

    Anné H. Verhoef

    2016-09-01

    Full Text Available To argue that the concept of natural law can be regarded, with certain conditions, as a credible and useful tool in the Reformed paradigm, as Vorster did, may at first seems to be in conflict with the Reformation’s emphasis on sola scriptura and sola gratia. Vorster, however, argues very convincingly that the general revelation of God and creational gifts can be a source for bioethics within the reformed tradition. He does this by relying on Calvin and Bavinck’s appreciative theologies and in reaction to Barth and Welker’s critique to the notion of natural law. In this article I will further Vorster’s argument by identifying some critical points in his argument, analyse the critique on these points and broaden the discussion by incorporating an eschatological perspective and the anthropology of the Protestant philosopher, Paul Ricoeur. The aim is, as Vorster states in his conclusion, to provide Christian ethics with opportunities and means to formulate applicable and relevant moral codes that can be utilised in the bio- and eco-ethical debates of today.

  18. H:\\USERS\\lex12\\skyf\\LVSA kongresreferaat (Lexikos)1

    African Journals Online (AJOL)

    Riette Ruthven

    guage relativity implies that each of the languages concerned gives a unique perspective on its own reality, because of a unique life- and world-view which form an inherent part of a particular mother tongue. Important metalexicographic guidelines include the judicious application of prag- matic signals (e.g. labels), ...

  19. Talus Lex: Regulatory Approaches to Reducing Mercury Concentrations in San Francisco Bay Fish.

    Science.gov (United States)

    Abu-Saba, D. E.; Flegal, D. R.; Ganguli, P. M.; Whyte, D. C.; Mumley, D. E.; Mason, D. P.

    2001-12-01

    The history of mercury in California is recorded in the sediments of San Francisco Bay. The Bay is downstream of 40 percent of the land area of California. Its watershed receives 80 percent of the rainfall in the State, because it rains more in the north. Three billion kilograms of sediments are annually flushed from the Central Valley watershed and deposited in San Francisco Bay. Because mercury preferentially binds to sediments, we calculate mercury loads to the Bay by considering how various sources affect mercury concentrations in Bay sediments. During and after the Gold Rush, over seventy thousand tons of mercury was produced in Coast Range cinnabar mines. Much of this mercury was used as quicksilver to extract gold from placer formations in the Sierra foothills, and later in the production of munitions, electronics, health care and commercial products. Today, we can see the legacy of mining sources, from both remote and local watersheds, superimposed on air deposition, the climate and geography of California, heavily managed water supply and flood control projects, wetland restoration and rehabilitation, urbanization, wastewaster discharge and water reclamation. We already regulate wastewater and urban runoff through issuance of permits and waste discharge requirements. We can regulate mercury inputs from inoperative mines by demonstrating the link between mercury-polluted sediments and violation of existing numeric water quality objectives. We can use the same approach to regulate the disposal of mercury-containing electronic devices. But to reduce mercury levels in fish, we will also have to consider controllable water quality factors that promote mercury methylation in the aquatic ecosystem. Some of these water quality factors are already subject to regulation. For example, we can show that mercury methylation in the northern reach of the Bay increases when dissolved oxygen drops below 6 mg/L; current regulations require dissolved oxygen concentrations of 7 mg/L or more in that region. But many of the processes that influence mercury bioaccumulation, such as microbial assemblage, sulfate concentration, and organic carbon loading, are complex, interacting factors that cannot be expressed as simple numeric limits. The Water Quality Control Plan for San Francisco Bay has a narrative objective for bioaccumulation that states that "controllable water quality factors shall not cause a detrimental increase in the concentrations of toxic substances found in bottom sediments or aquatic life." To effectively implement that objective, we need basic science research to develop sound guidance for the creation, restoration, and management of wetlands and marshes surrounding the Bay.

  20. Calculs et rationalités dans la seigneurie médiévale : les conversions de redevances entre xie et xve siècles

    Directory of Open Access Journals (Sweden)

    Laurent Feller

    2010-10-01

    Full Text Available Les 26 et 27 octobre 2006, la maison du Coche d’Eau accueillait une rencontre scientifique portant sur les conversions de redevance dans la seigneurie médiévale dont les actes sont contenus dans cet ouvrage.Dans le cadre d’une réflexion collective animée par le Lamop sur la circulation des richesses au Moyen Âge, cet ouvrage de référence définit certains des critères guidant la prise de décision des seigneurs en matière de politique économique. Il démontre que, loin d’être des surconsommateur...

  1. Expansion of the gateway multisite recombination cloning toolkit.

    Science.gov (United States)

    Shearin, Harold K; Dvarishkis, Alisa R; Kozeluh, Craig D; Stowers, R Steven

    2013-01-01

    Precise manipulation of transgene expression in genetic model organisms has led to advances in understanding fundamental mechanisms of development, physiology, and genetic disease. Transgene construction is, however, a precondition of transgene expression, and often limits the rate of experimental progress. Here we report an expansion of the modular Gateway MultiSite recombination-cloning platform for high efficiency transgene assembly. The expansion includes two additional destination vectors and entry clones for the LexA binary transcription system, among others. These new tools enhance the expression levels possible with Gateway MultiSite generated transgenes and make possible the generation of LexA drivers and reporters with Gateway MultiSite cloning. In vivo data from transgenic Drosophila functionally validating each novel component are presented and include neuronal LexA drivers, LexAop2 red and green fluorescent synaptic vesicle reporters, TDC2 and TRH LexA, GAL4, and QF drivers, and LexAop2, UAS, and QUAS channelrhodopsin2 T159C reporters.

  2. Using an extended 2D hydrodynamic model for evaluating damage risk caused by extreme rain events: Flash-Flood-Risk-Map (FFRM) Upper Austria

    Science.gov (United States)

    Humer, Günter; Reithofer, Andreas

    2016-04-01

    Using an extended 2D hydrodynamic model for evaluating damage risk caused by extreme rain events: Flash-Flood-Risk-Map (FFRM) Upper Austria Considering the increase in flash flood events causing massive damage during the last years in urban but also rural areas [1-4], the requirement for hydrodynamic calculation of flash flood prone areas and possible countermeasures has arisen to many municipalities and local governments. Besides the German based URBAS project [1], also the EU-funded FP7 research project "SWITCH-ON" [5] addresses the damage risk caused by flash floods in the sub-project "FFRM" (Flash Flood Risk Map Upper Austria) by calculating damage risk for buildings and vulnerable infrastructure like schools and hospitals caused by flash-flood driven inundation. While danger zones in riverine flooding are established as an integral part of spatial planning, flash floods caused by overland runoff from extreme rain events have been for long an underrated safety hazard not only for buildings and infrastructure, but man and animals as well. Based on the widespread 2D-model "hydro_as-2D", an extension was developed, which calculates the runoff formation from a spatially and temporally variable precipitation and determines two dimensionally the land surface area runoff and its concentration. The conception of the model is to preprocess the precipitation data and calculate the effective runoff-volume for a short time step of e.g. five minutes. This volume is applied to the nodes of the 2D-model and the calculation of the hydrodynamic model is started. At the end of each time step, the model run is stopped, the preprocessing step is repeated and the hydraulic model calculation is continued. In view of the later use for the whole of Upper Austria (12.000 km²) a model grid of 25x25 m² was established using digital elevation data. Model parameters could be estimated for the small catchment of river Ach, which was hit by an intense rain event with up to 109 mm per hour

  3. The ICTP Regional System Model (RESM) to simulate the monsoon in the South Asia CORDEX domain

    Science.gov (United States)

    Di Sante, Fabio; Coppola, Erika; Farneti, Riccardo; Giorgi, Filippo

    2016-04-01

    . The impact of a simplified low-resolution hydrological model (HD model) and the physical based high-resolution hydrological model (CHyM model) is also assessed in the fully coupled RESM simulations. References: 1) Fu, X., Wang, B. and Li, T., 2002: Impacts of air-sea coupling on the simulation of mean Asian summer monsoon in the ECHAM4 model, Mon. Wea. Rev., 130, 2889-2904. 2) Fu, X., Wang, B., Waliser, D. E. and Tao, L., 2007: Impact of atmosphere-ocean coupling on the predictability of monsoon interseasonal oscillations, J. Atmos. Sci., 64,157-174. 3) Ratnam J. Venkata, Filippo Giorgi, Akshara Kaginalkar, Stefano Cozzini, 2008b: Simulation of Indian Monsoon using RegCM3 - ROMS regional coupled model, Climate Dynamics, 1432-0894. 4) Seo, H, Xie SP, Murtgudde R, Jochum M, Miller AJ. 2009. Seasonal effects of Indian Ocean freshwater forcing in a regional coupled model. Journal of Climate. 22:6577-6596. 5) Giorgi, F., et al. 2012: RegCM4: Model description and preliminary tests over multiple CORDEX domains, Clim. Res., 53(1), 7-29. 6) Marshall, J., C. Hill, L. Perelman, and A. Adcroft, 1997: Hydrostatic, quasi-hydrostatic, and nonhydrostatic ocean modeling. J. Geophysical Res., 102(C3), 5733-5752. 7) Hagemann, S., Dumenil, L., 1998: Application of a grid-scale lateral discharge model in the BALTEX region. MPI-Report No. 278 8) Coppola, E., Tomasetti, B., Mariotti, L., Verdecchia, M., Visconti, G., 2007: Cellular automata algorithms for drainage network extraction and rainfall data assimilation. Hydrol Sci J 2007;52(3). 9) Giorgi F., Jones C. Asrar G., 2009: Addressing climate information needs at the regional level: the CORDEX framework. WMO Bull 58:175-183

  4. Frequency-Dependent Nature of Pn in Western China

    Science.gov (United States)

    2009-09-30

    travel times and procedures for depth determination. Bull. Seism . Sot: Am. 88: 722-743. 174 2009 Monitoring Research Review: Ground-Based Nuclear...Bull. Seism . Soc. Am. 93: 2146-2159. Lay, T., X. B. Xie and X. Yang (2008). Development of regional phase tomographic attenuation models for Eurasia...studies, Geophys. Res. Lett. 34: doi:10.1029/2007GL029338. Yang, X., T. Lay, X. B. Xie, and M. S. Thorne (2007). Geometric spreading of Pn and Sn in a spherical earth model, Bull. Seism . Soc. Am. 97: 2053-2065. 175

  5. airGRteaching: an R-package designed for teaching hydrology with lumped hydrological models

    Science.gov (United States)

    Thirel, Guillaume; Delaigue, Olivier; Coron, Laurent; Andréassian, Vazken; Brigode, Pierre

    2017-04-01

    discharges, which are updated immediately (a calibration only needs a couple of seconds or less, a simulation is almost immediate). In addition, time series of internal variables, live-visualisation of internal variables evolution and performance statistics are provided. This interface allows for hands-on exercises that can include for instance the analysis by students of: - The effects of each parameter and model components on simulated discharge - The effects of objective functions based on high flows- or low flows-focused criteria on simulated discharge - The seasonality of the model components. References Winston Chang, Joe Cheng, JJ Allaire, Yihui Xie and Jonathan McPherson (2016). shiny: Web Application Framework for R. R package version 0.13.2. https://CRAN.R-project.org/package=shiny Coron L., Thirel G., Perrin C., Delaigue O., Andréassian V., airGR: a suite of lumped hydrological models in an R-package, Environmental Modelling and software, 2017, submitted. Coron, L., Perrin, C. and Michel, C. (2016). airGR: Suite of GR hydrological models for precipitation-runoff modelling. R package version 1.0.3. https://webgr.irstea.fr/airGR/?lang=en. Olivier Delaigue and Laurent Coron (2016). airGRteaching: Tools to simplify the use of the airGR hydrological package by students. R package version 0.0.1. https://webgr.irstea.fr/airGR/?lang=en R Core Team (2016). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R-project.org/.

  6. Preparation of liposomal amiodarone and investigation of its cardiomyocyte-targeting ability in cardiac radiofrequency ablation rat model

    Directory of Open Access Journals (Sweden)

    Zhuge Y

    2016-05-01

    Full Text Available Ying Zhuge,1,* Zhi-Feng Zheng,1,* Mu-Qing Xie,2 Lin Li,2 Fang Wang,1 Feng Gao2,3 1Department of Cardiology, Shanghai First People’s Hospital of Nanjing Medical University, 2Department of Pharmaceutics, School of Pharmacy, 3Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, People’s Republic of China*These authors contributed equally to this workAbstract: The objective of this study was to develop an amiodarone hydrochloride (ADHC-loaded liposome (ADHC-L formulation and investigate its potential for cardiomyocyte targeting after cardiac radiofrequency ablation (CA in vivo. The ADHC-L was prepared by thin-film method combined with ultrasonication and extrusion. The preparation process was optimized by Box–Behnken design with encapsulation efficiency as the main evaluation index. The optimum formulation was quantitatively obtained with a diameter of 99.9±0.4 nm, a zeta potential of 35.1±10.9 mV, and an encapsulation efficiency of 99.5%±13.3%. Transmission electron microscopy showed that the liposomes were spherical particles with integrated bilayers and well dispersed with high colloidal stability. Pharmacokinetic studies were investigated in rats after intravenous administration, which revealed that compared with free ADHC treatment, ADHC-L treatment showed a 5.1-fold increase in the area under the plasma drug concentration–time curve over a period of 24 hours (AUC0–24 h and an 8.5-fold increase in mean residence time, suggesting that ADHC-L could facilitate drug release in a more stable and sustained manner while increasing the circulation time of ADHC, especially in the blood. Biodistribution studies of ADHC-L demonstrated that ADHC concentration in the heart was 4.1 times higher after ADHC-L treatment in CA rat model compared with ADHC-L sham-operated treatment at 20 minutes postinjection. Fluorescence imaging studies further proved that the heart

  7. The Effect of PM2.5 from Household Combustion on Life Expectancy in Sub-Saharan Africa

    Directory of Open Access Journals (Sweden)

    Badamassi Aboubacar

    2018-04-01

    Full Text Available Household fuel combustion, especially using solid combustibles (biomass and fossil fuels, for cooking and other activities produces emissions that contribute to concentrations of indoor as well as outdoor air pollutants such as particulate matter with diameter smaller than 2.5 μm (PM2.5 that deteriorate health and likely affect life expectancy (LEX. This study investigates the impact of PM2.5 from household combustion on LEX considering several covariates while controlling for ambient PM2.5 generated by other sectors. The generalized method of moments (GMM model and the panel cointegration model were applied to a dataset of 43 Sub-Saharan Africa (SSA countries over the time period of 1995–2010. Both approaches provide similar results indicating that household PM2.5 is significantly and negatively associated with higher aggregate LEX in the long-run, and, to a greater degree for female’s. Also, among the control variables, PM2.5 from the transport sector has a greater influence on male’s LEX. Thus, efforts should be combined to reduce household PM2.5 since lower levels are associated with increased LEX.

  8. Refractive lenticule extraction (ReLEx through a small incision (SMILE for correction of myopia and myopic astigmatism: current perspectives

    Directory of Open Access Journals (Sweden)

    Ağca A

    2016-10-01

    Full Text Available Alper Ağca,1 Ahmet Demirok,2 Yusuf Yıldırım,1 Ali Demircan,1 Dilek Yaşa,1 Ceren Yeşilkaya,1 İrfan Perente,1 Muhittin Taşkapılı1 1Beyoğlu Eye Research and Training Hospital, 2Department of Ophthalmology, Istanbul Medeniyet University, Istanbul, Turkey Abstract: Small-incision lenticule extraction (SMILE is an alternative to laser-assisted in situ keratomileusis (LASIK and photorefractive keratectomy (PRK for the correction of myopia and myopic astigmatism. SMILE can be performed for the treatment of myopia ≤-12 D and astigmatism ≤5 D. The technology is currently only available in the VisuMax femtosecond laser platform. It offers several advantages over LASIK and PRK; however, hyperopia treatment, topography-guided treatment, and cyclotorsion control are not available in the current platform. The working principles, potential advantages, and disadvantages are discussed in this review. Keywords: SMILE, small-incision lenticule extraction, femtosecond laser, laser in situ keratomileusis, corneal biomechanics

  9. La intertextualidad en el cine de Álex de la Iglesia:El caso del cómic

    Directory of Open Access Journals (Sweden)

    Neftalí Pérez Franco

    2010-10-01

    Full Text Available Este artículo repasa la influencia del tebeo en las películas del director vasco, Alex de la Iglesia, cuyas primeras obras artísticas se deben a su condición de joven autor de historietas. El cine de este cineasta está marcado por claras reminiscencias provenientes de las viñetas: los superhéroes patéticos de Acción mutante se mueven por un contexto futurista muy del cómic de ciencia ficción; el humor estereotipado y los personajes grotescos del tebeo de la editorial Bruguera inundan todas sus comedias; o también son destacables los diversos homenajes narrativos o estéticos a la escuela franco-belga de Hergé y Goscinny. Esta fuerte influencia recorre toda su filmografía desde la mencionada ópera prima Acción mutante, hasta Crimen Ferpecto, pasando por títulos como El día de la bestia, Perdita Durango, Muertos de risa o La comunidad, hasta convertirse en un autor abanderado del fenómeno freak que marca tendencia en el cine español.

  10. El Madrid de la Bestia : l’apocalypse urbaine d’Álex de la Iglesia

    OpenAIRE

    Bracco, Diane

    2014-01-01

    Loin de se réduire à un simple décor, la capitale espagnole joue un rôle prépondérant dans le second long métrage d’Alex de la Iglesia, El día de la bestia, où elle est dépeinte comme un organisme rongé par la violence. Cet article a pour objectif d’analyser les variations autour du thème de l’apocalypse, pierre angulaire du portrait cinématographique que le réalisateur dresse, dans son film, du Madrid contemporain. En déployant les stratégies narratives de la distorsion grotesque, de la Igle...

  11. Lexém dietě ve staré češtině

    Czech Academy of Sciences Publication Activity Database

    Vajdlová, Miloslava

    2013-01-01

    Roč. 13, č. 2 (2013), s. 19-25 ISSN 1802-825X R&D Projects: GA ČR GAP406/10/1153 Institutional support: RVO:68378092 Keywords : lexeme dietě (Cz) * Old Czech * semantic analysis * meanings Subject RIV: AI - Linguistics http://www.pf.ujep.cz/files/KBO/USTA/Usta_2013-2.pdf

  12. Inter-Comparison of Retrieved and Modelled Soil Moisture and Coherency of Remotely Sensed Hydrology Data

    Science.gov (United States)

    Kolassa, Jana; Aires, Filipe

    2013-04-01

    hydrological processes. In addition, a regional analysis was conducted over several large river basins, including a detailed analysis of the time-lagged correlations between the three datasets and the spatial propagation of observed signals. Results appear consistent with the knowledge of the hydrological processes governing the individual basins. References Adler, R.F., G.J. Huffman, A. Chang, R. Ferraro, P. Xie, J. Janowiak, B. Rudolf, U. Schneider, S. Curtis, D. Bolvin, A. Gruber, J. Susskind, and P. Arkin (2003), The Version 2 Global Precipita- tion Climatology Project (GPCP) Monthly Precipitation Analysis (1979-Present).J. Hydrometeor., 4,1147-1167. Balsamo, G., Viterbo, P., Beljaars, A., van den Hurk, B., Hirschi, M., Betts, A. and Scipa,l K. (2009) A Revised Hydrology for the ECMWF Model: Verification from Field Site to Terrestrial Water Storage and Impact in the Integrated Forecast System, J. Hydrol., 10, 623-643 Dorigo, W. A., Wagner, W., Hohensinn, R., Hahn, S., Paulik, C., Xaver, A., Gruber, A., Drusch, M., Mecklenburg, S., van Oevelen, P., Robock, A., and Jackson, T. (2011), The International Soil Moisture Network: a data hosting facility for global in situ soil moisture measurements, Hydrol. Earth Syst. Sci., 15, 1675-1698 Kolassa, J., Aires, F., Polcher, J., Prigent, C., and Pereira, J. (2012), Soil moisture Retrieval from Multi-instrument Observations: Information Content Analysis and Retrieval Methodology (2012), J. Geophys. Res., Liu, Y. Y., Parinussa, R. M., Dorigo, W. A., De Jeu, R. A. M., Wagner, W., van Dijk, A. I. J. M., McCabe, M. F., and Evans, J. P.(2011), Developing an improved soil moisture dataset by blending passive and active microwave satellite-based retrievals, Hydrol. Earth Syst. Sci., 15, 425-436. Prigent, C., F. Papa, F. Aires, W. B. Rossow, and E. Matthews (2007), Global inundation dy- namics inferred from multiple satellite observations, 1993-2000, J. Geophys. Res., 112, D12107, doi:10.1029/2006JD007847.

  13. Solène Daoudal, Sirènes romanes en Poitou, XIe-XIIe siècles. Avatars sculptés d’une figure mythique

    Directory of Open Access Journals (Sweden)

    Didier Lett

    2009-07-01

    Full Text Available Vers 1140, dans la toute dernière lettre qu’il adresse à Héloïse, comme pour se rassurer face à « l’histoire de ses malheurs », Abélard termine par ces mots : « A l'abri de cette foi salutaire, je ne crains pas les aboiements de Scylla, je me ris des gouffres de Charybde, et j’entends sans frémir les chants des sirènes. Si la tempête éclate, je ne suis pas renversé. Si les vents grondent, je ne suis pas ému. Je suis fondé sur une pierre inébranlable ». Dans cet autoportrait du penseur scolast...

  14. Model(ing) Law

    DEFF Research Database (Denmark)

    Carlson, Kerstin

    The International Criminal Tribunal for the former Yugoslavia (ICTY) was the first and most celebrated of a wave of international criminal tribunals (ICTs) built in the 1990s designed to advance liberalism through international criminal law. Model(ing) Justice examines the case law of the ICTY...

  15. Models and role models

    NARCIS (Netherlands)

    ten Cate, J.M.

    2015-01-01

    Developing experimental models to understand dental caries has been the theme in our research group. Our first, the pH-cycling model, was developed to investigate the chemical reactions in enamel or dentine, which lead to dental caries. It aimed to leverage our understanding of the fluoride mode of

  16. Challenges of Testing Deep Word Knowledge of Vocabulary: Which ...

    African Journals Online (AJOL)

    The present research explores the challenges of testing deep word knowledge of the vocabulary of students of English as a Foreign/Second Language (EFL/ESL) at higher education. A productive test modelled on the Lex30 test developed by Meara and Fitzpatrick (2000) was presented to the participants. Results indicate ...

  17. Cognitive modeling

    OpenAIRE

    Zandbelt, Bram

    2017-01-01

    Introductory presentation on cognitive modeling for the course ‘Cognitive control’ of the MSc program Cognitive Neuroscience at Radboud University. It addresses basic questions, such as 'What is a model?', 'Why use models?', and 'How to use models?'

  18. Modelling the models

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    By analysing the production of mesons in the forward region of LHC proton-proton collisions, the LHCf collaboration has provided key information needed to calibrate extremely high-energy cosmic ray models.   Average transverse momentum (pT) as a function of rapidity loss ∆y. Black dots represent LHCf data and the red diamonds represent SPS experiment UA7 results. The predictions of hadronic interaction models are shown by open boxes (sibyll 2.1), open circles (qgsjet II-03) and open triangles (epos 1.99). Among these models, epos 1.99 shows the best overall agreement with the LHCf data. LHCf is dedicated to the measurement of neutral particles emitted at extremely small angles in the very forward region of LHC collisions. Two imaging calorimeters – Arm1 and Arm2 – take data 140 m either side of the ATLAS interaction point. “The physics goal of this type of analysis is to provide data for calibrating the hadron interaction models – the well-known &...

  19. Modelling Practice

    DEFF Research Database (Denmark)

    Cameron, Ian; Gani, Rafiqul

    2011-01-01

    This chapter deals with the practicalities of building, testing, deploying and maintaining models. It gives specific advice for each phase of the modelling cycle. To do this, a modelling framework is introduced which covers: problem and model definition; model conceptualization; model data...... requirements; model construction; model solution; model verification; model validation and finally model deployment and maintenance. Within the adopted methodology, each step is discussedthrough the consideration of key issues and questions relevant to the modelling activity. Practical advice, based on many...... years of experience is providing in directing the reader in their activities.Traps and pitfalls are discussed and strategies also given to improve model development towards “fit-for-purpose” models. The emphasis in this chapter is the adoption and exercise of a modelling methodology that has proven very...

  20. Using ARM Measurements to Understand and Reduce the Double ITCZ Biases in the Community Atmospheric Model

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Minghua [Stony Brook Univ., NY (United States)

    2016-12-08

    the longitude-latitude grid setting of CESM and the more stable (unstable) atmosphere. This parameterization is expected lead to more realistic simulation of tropical precipitation in high-resolution models. Results from this study are reported in Xie and Zhang (2015).

  1. Wind tunnel investigation of the interaction and breakdown characteristics of slender wing vortices at subsonic, transonic, and supersonic speeds

    Science.gov (United States)

    Erickson, Gary E.

    1991-01-01

    The vortex dominated aerodynamic characteristics of a generic 65 degree cropped delta wing model were studied in a wind tunnel at subsonic through supersonic speeds. The lee-side flow fields over the wing-alone configuration and the wing with leading edge extension (LEX) added were observed at M (infinity) equals 0.40 to 1.60 using a laser vapor screen technique. These results were correlated with surface streamline patterns, upper surface static pressure distributions, and six-component forces and moments. The wing-alone exhibited vortex breakdown and asymmetry of the breakdown location at the subsonic and transonic speeds. An earlier onset of vortex breakdown over the wing occurred at transonic speeds due to the interaction of the leading edge vortex with the normal shock wave. The development of a shock wave between the vortex and wing surface caused an early separation of the secondary boundary layer. With the LEX installed, wing vortex breakdown asymmetry did not occur up to the maximum angle of attack in the present test of 24 degrees. The favorable interaction of the LEX vortex with the wing flow field reduced the effects of shock waves on the wing primary and secondary vortical flows. The direct interaction of the wing and LEX vortex cores diminished with increasing Mach number. The maximum attainable vortex-induced pressure signatures were constrained by the vacuum pressure limit at the transonic and supersonic speeds.

  2. STRUCTURAL MODELLING

    Directory of Open Access Journals (Sweden)

    Tea Ya. Danelyan

    2014-01-01

    Full Text Available The article states the general principles of structural modeling in aspect of the theory of systems and gives the interrelation with other types of modeling to adjust them to the main directions of modeling. Mathematical methods of structural modeling, in particular method of expert evaluations are considered.

  3. (HEV) Model

    African Journals Online (AJOL)

    Moatez Billah HARIDA

    The use of the simulator “Hybrid Electrical Vehicle Model Balances Fidelity and. Speed (HEVMBFS)” and the global control strategy make it possible to achieve encouraging results. Key words: Series parallel hybrid vehicle - nonlinear model - linear model - Diesel engine - Engine modelling -. HEV simulator - Predictive ...

  4. Constitutive Models

    DEFF Research Database (Denmark)

    Sales-Cruz, Mauricio; Piccolo, Chiara; Heitzig, Martina

    2011-01-01

    This chapter presents various types of constitutive models and their applications. There are 3 aspects dealt with in this chapter, namely: creation and solution of property models, the application of parameter estimation and finally application examples of constitutive models. A systematic...... procedure is introduced for the analysis and solution of property models. Models that capture and represent the temperature dependent behaviour of physical properties are introduced, as well as equation of state models (EOS) such as the SRK EOS. Modelling of liquid phase activity coefficients are also...

  5. Model theory

    CERN Document Server

    Chang, CC

    2012-01-01

    Model theory deals with a branch of mathematical logic showing connections between a formal language and its interpretations or models. This is the first and most successful textbook in logical model theory. Extensively updated and corrected in 1990 to accommodate developments in model theoretic methods - including classification theory and nonstandard analysis - the third edition added entirely new sections, exercises, and references. Each chapter introduces an individual method and discusses specific applications. Basic methods of constructing models include constants, elementary chains, Sko

  6. Galactic models

    International Nuclear Information System (INIS)

    Buchler, J.R.; Gottesman, S.T.; Hunter, J.H. Jr.

    1990-01-01

    Various papers on galactic models are presented. Individual topics addressed include: observations relating to galactic mass distributions; the structure of the Galaxy; mass distribution in spiral galaxies; rotation curves of spiral galaxies in clusters; grand design, multiple arm, and flocculent spiral galaxies; observations of barred spirals; ringed galaxies; elliptical galaxies; the modal approach to models of galaxies; self-consistent models of spiral galaxies; dynamical models of spiral galaxies; N-body models. Also discussed are: two-component models of galaxies; simulations of cloudy, gaseous galactic disks; numerical experiments on the stability of hot stellar systems; instabilities of slowly rotating galaxies; spiral structure as a recurrent instability; model gas flows in selected barred spiral galaxies; bar shapes and orbital stochasticity; three-dimensional models; polar ring galaxies; dynamical models of polar rings

  7. Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

    DEFF Research Database (Denmark)

    Xie, Kan; Neff, Frauke; Markert, Astrid

    2017-01-01

    that every-other-day feeding-induced longevity is sufficiently explained by delays in life-limiting neoplastic disorders and is not associated with a more general slowing of the aging process in mice.Dietary restriction can extend the life of various model organisms. Here, Xie et al. show that intermittent...... periods of fasting achieved through every-other-day feeding protect mice against neoplastic disease but do not broadly delay organismal aging in animals....

  8. Interface models

    DEFF Research Database (Denmark)

    Ravn, Anders P.; Staunstrup, Jørgen

    1994-01-01

    This paper proposes a model for specifying interfaces between concurrently executing modules of a computing system. The model does not prescribe a particular type of communication protocol and is aimed at describing interfaces between both software and hardware modules or a combination of the two....... The model describes both functional and timing properties of an interface...

  9. Hydrological models are mediating models

    Science.gov (United States)

    Babel, L. V.; Karssenberg, D.

    2013-08-01

    Despite the increasing role of models in hydrological research and decision-making processes, only few accounts of the nature and function of models exist in hydrology. Earlier considerations have traditionally been conducted while making a clear distinction between physically-based and conceptual models. A new philosophical account, primarily based on the fields of physics and economics, transcends classes of models and scientific disciplines by considering models as "mediators" between theory and observations. The core of this approach lies in identifying models as (1) being only partially dependent on theory and observations, (2) integrating non-deductive elements in their construction, and (3) carrying the role of instruments of scientific enquiry about both theory and the world. The applicability of this approach to hydrology is evaluated in the present article. Three widely used hydrological models, each showing a different degree of apparent physicality, are confronted to the main characteristics of the "mediating models" concept. We argue that irrespective of their kind, hydrological models depend on both theory and observations, rather than merely on one of these two domains. Their construction is additionally involving a large number of miscellaneous, external ingredients, such as past experiences, model objectives, knowledge and preferences of the modeller, as well as hardware and software resources. We show that hydrological models convey the role of instruments in scientific practice by mediating between theory and the world. It results from these considerations that the traditional distinction between physically-based and conceptual models is necessarily too simplistic and refers at best to the stage at which theory and observations are steering model construction. The large variety of ingredients involved in model construction would deserve closer attention, for being rarely explicitly presented in peer-reviewed literature. We believe that devoting

  10. ICRF modelling

    International Nuclear Information System (INIS)

    Phillips, C.K.

    1985-12-01

    This lecture provides a survey of the methods used to model fast magnetosonic wave coupling, propagation, and absorption in tokamaks. The validity and limitations of three distinct types of modelling codes, which will be contrasted, include discrete models which utilize ray tracing techniques, approximate continuous field models based on a parabolic approximation of the wave equation, and full field models derived using finite difference techniques. Inclusion of mode conversion effects in these models and modification of the minority distribution function will also be discussed. The lecture will conclude with a presentation of time-dependent global transport simulations of ICRF-heated tokamak discharges obtained in conjunction with the ICRF modelling codes. 52 refs., 15 figs

  11. Análisis de las bases de datos: El Derecho, Westlaw España, vLex Premium y La Ley Digital

    OpenAIRE

    López Hurtado, Mariana; Valentín Ruiz, Francisco José

    2009-01-01

    Este análisis recoge un estudio de las cuatro principales bases de datos relacionadas con el Derecho: “El Derecho”, “Westlaw España”, “vLex”, y “La Ley Digital”. El objetivo de este trabajo es la identificación de los aspectos positivos y los que deben mejorarse dentro de cada una de las cuatro bases de datos, con el fin de presentar una visión objetiva que permita seleccionar la base de datos más adecuada para cada tipo de institución, atendiendo a sus necesidades específicas. Para el pre...

  12. Immunohistochemical analysis of LNT, NeuAc2----3LNT, and Lex carbohydrate antigens in human tumors and normal tissues.

    OpenAIRE

    Garin-Chesa, P.; Rettig, W. J.

    1989-01-01

    Monoclonal antibodies (MAbs) K21 and K4 define two carbohydrate determinants, lacto-N-tetraose (LNT) and sialylated LNT (NeuAc2----3LNT). respectively, which are expressed on the surface of cultured human teratocarcinoma cells, but not on a wide range of other epithelial and nonepithelial cells in culture. The present study used immunohistochemical methods to examine LNT and NeuAc2----3LNT expression in normal human tissues, 29 germ cell tumors, and over 200 tumors of other histologic types. ...

  13. Estructuras políticas menores en la tarraconense de época adrianea: el pagus en la lex rivi hiberiensis

    OpenAIRE

    Torrent, Armando

    2014-01-01

    El Bronce de Agón demuestra la funcionalidad de los pagi y sus representantes electos, aunque el documento se centre fundamentalmente sobre el régimen y explotación del agua, describiendo minuciosamente la estructura de una asociación de regantes que demuestra una vigorosa vida corporativa con instrumentos procesales para exigir responsabilidad a los magistri pagi y a los pagani que no cumplieran las obligaciones previstas en la ley; en resumen, creo que la LrH no es menos importante que la l...

  14. Cross-border Transfer and Change of Lex Societatis After Polbud, C-106/16: Old Companies Do Not Die .... They Simply Fade Away to Another Country

    DEFF Research Database (Denmark)

    Sørensen, Anne Birgitte Søgaard; Werlauff, Erik

    2018-01-01

    The article analyses the Polbud-case C-106/16 and shows how this case adds an important new piece to the jigsaw puzzle of understanding the concept of freedom of establishment in EU-law. Polbud introduces new answers to questions about the cross-border conversion of companies, but it also reaffirms...... and clarifies well-known principles attached to the concept of freedom of establishment in EU-law. It must be concluded, that a brass plate in the host member state is still enough in some respects, and so in the Polbud case, but not in others. The case clearly gives some seal of approval to the concept......, and customers (economic activities) where business opportunities may seem to be the better....

  15. Podzelená: pozoruhodný lexém z prostředí českožidovské komunity

    Czech Academy of Sciences Publication Activity Database

    Bartoň, Josef

    2005-01-01

    Roč. 74, 2-3 (2005), s. 303-312 ISSN 0037-6736 Institutional research plan: CEZ:AV0Z90090514 Keywords : Czech language * Jewish sociolect * religious expressions Subject RIV: AA - Philosophy ; Religion

  16. Modelling in Business Model design

    NARCIS (Netherlands)

    Simonse, W.L.

    2013-01-01

    It appears that business model design might not always produce a design or model as the expected result. However when designers are involved, a visual model or artefact is produced. To assist strategic managers in thinking about how they can act, the designers challenge is to combine strategy and

  17. Symbolic Computation of Strongly Connected Components Using Saturation

    Science.gov (United States)

    Zhao, Yang; Ciardo, Gianfranco

    2010-01-01

    Finding strongly connected components (SCCs) in the state-space of discrete-state models is a critical task in formal verification of LTL and fair CTL properties, but the potentially huge number of reachable states and SCCs constitutes a formidable challenge. This paper is concerned with computing the sets of states in SCCs or terminal SCCs of asynchronous systems. Because of its advantages in many applications, we employ saturation on two previously proposed approaches: the Xie-Beerel algorithm and transitive closure. First, saturation speeds up state-space exploration when computing each SCC in the Xie-Beerel algorithm. Then, our main contribution is a novel algorithm to compute the transitive closure using saturation. Experimental results indicate that our improved algorithms achieve a clear speedup over previous algorithms in some cases. With the help of the new transitive closure computation algorithm, up to 10(exp 150) SCCs can be explored within a few seconds.

  18. Ventilation Model

    International Nuclear Information System (INIS)

    Yang, H.

    1999-01-01

    The purpose of this analysis and model report (AMR) for the Ventilation Model is to analyze the effects of pre-closure continuous ventilation in the Engineered Barrier System (EBS) emplacement drifts and provide heat removal data to support EBS design. It will also provide input data (initial conditions, and time varying boundary conditions) for the EBS post-closure performance assessment and the EBS Water Distribution and Removal Process Model. The objective of the analysis is to develop, describe, and apply calculation methods and models that can be used to predict thermal conditions within emplacement drifts under forced ventilation during the pre-closure period. The scope of this analysis includes: (1) Provide a general description of effects and heat transfer process of emplacement drift ventilation. (2) Develop a modeling approach to simulate the impacts of pre-closure ventilation on the thermal conditions in emplacement drifts. (3) Identify and document inputs to be used for modeling emplacement ventilation. (4) Perform calculations of temperatures and heat removal in the emplacement drift. (5) Address general considerations of the effect of water/moisture removal by ventilation on the repository thermal conditions. The numerical modeling in this document will be limited to heat-only modeling and calculations. Only a preliminary assessment of the heat/moisture ventilation effects and modeling method will be performed in this revision. Modeling of moisture effects on heat removal and emplacement drift temperature may be performed in the future

  19. Turbulence modelling

    International Nuclear Information System (INIS)

    Laurence, D.

    1997-01-01

    This paper is an introduction course in modelling turbulent thermohydraulics, aimed at computational fluid dynamics users. No specific knowledge other than the Navier Stokes equations is required beforehand. Chapter I (which those who are not beginners can skip) provides basic ideas on turbulence physics and is taken up in a textbook prepared by the teaching team of the ENPC (Benque, Viollet). Chapter II describes turbulent viscosity type modelling and the 2k-ε two equations model. It provides details of the channel flow case and the boundary conditions. Chapter III describes the 'standard' (R ij -ε) Reynolds tensions transport model and introduces more recent models called 'feasible'. A second paper deals with heat transfer and the effects of gravity, and returns to the Reynolds stress transport model. (author)

  20. Mathematical modelling

    CERN Document Server

    2016-01-01

    This book provides a thorough introduction to the challenge of applying mathematics in real-world scenarios. Modelling tasks rarely involve well-defined categories, and they often require multidisciplinary input from mathematics, physics, computer sciences, or engineering. In keeping with this spirit of modelling, the book includes a wealth of cross-references between the chapters and frequently points to the real-world context. The book combines classical approaches to modelling with novel areas such as soft computing methods, inverse problems, and model uncertainty. Attention is also paid to the interaction between models, data and the use of mathematical software. The reader will find a broad selection of theoretical tools for practicing industrial mathematics, including the analysis of continuum models, probabilistic and discrete phenomena, and asymptotic and sensitivity analysis.

  1. Modelling Overview

    DEFF Research Database (Denmark)

    Larsen, Lars Bjørn; Vesterager, Johan

    sharing many of the characteristics of a virtual enterprise. This extended enterprise will have the following characteristics: The extended enterprise is focused on satisfying the current customer requirement so that it has a limited life expectancy, but should be capable of being recreated to deal....... One or more units from beyond the network may complement the extended enterprise. The common reference model for this extended enterprise will utilise GERAM (Generalised Enterprise Reference Architecture and Methodology) to provide an architectural framework for the modelling carried out within......This report provides an overview of the existing models of global manufacturing, describes the required modelling views and associated methods and identifies tools, which can provide support for this modelling activity.The model adopted for global manufacturing is that of an extended enterprise...

  2. Mathematical modelling

    DEFF Research Database (Denmark)

    Blomhøj, Morten

    2004-01-01

    modelling, however, can be seen as a practice of teaching that place the relation between real life and mathematics into the centre of teaching and learning mathematics, and this is relevant at all levels. Modelling activities may motivate the learning process and help the learner to establish cognitive......Developing competences for setting up, analysing and criticising mathematical models are normally seen as relevant only from and above upper secondary level. The general belief among teachers is that modelling activities presuppose conceptual understanding of the mathematics involved. Mathematical...... roots for the construction of important mathematical concepts. In addition competences for setting up, analysing and criticising modelling processes and the possible use of models is a formative aim in this own right for mathematics teaching in general education. The paper presents a theoretical...

  3. Event Modeling

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2001-01-01

    The purpose of this chapter is to discuss conceptual event modeling within a context of information modeling. Traditionally, information modeling has been concerned with the modeling of a universe of discourse in terms of information structures. However, most interesting universes of discourse...... are dynamic and we present a modeling approach that can be used to model such dynamics. We characterize events as both information objects and change agents (Bækgaard 1997). When viewed as information objects events are phenomena that can be observed and described. For example, borrow events in a library can...... be characterized by their occurrence times and the participating books and borrowers. When we characterize events as information objects we focus on concepts like information structures. When viewed as change agents events are phenomena that trigger change. For example, when borrow event occurs books are moved...

  4. Model : making

    OpenAIRE

    Bottle, Neil

    2013-01-01

    The Model : making exhibition was curated by Brian Kennedy in collaboration with Allies & Morrison in September 2013. For the London Design Festival, the Model : making exhibition looked at the increased use of new technologies by both craft-makers and architectural model makers. In both practices traditional ways of making by hand are increasingly being combined with the latest technologies of digital imaging, laser cutting, CNC machining and 3D printing. This exhibition focussed on ...

  5. Spherical models

    CERN Document Server

    Wenninger, Magnus J

    2012-01-01

    Well-illustrated, practical approach to creating star-faced spherical forms that can serve as basic structures for geodesic domes. Complete instructions for making models from circular bands of paper with just a ruler and compass. Discusses tessellation, or tiling, and how to make spherical models of the semiregular solids and concludes with a discussion of the relationship of polyhedra to geodesic domes and directions for building models of domes. "". . . very pleasant reading."" - Science. 1979 edition.

  6. Modeling Documents with Event Model

    Directory of Open Access Journals (Sweden)

    Longhui Wang

    2015-08-01

    Full Text Available Currently deep learning has made great breakthroughs in visual and speech processing, mainly because it draws lessons from the hierarchical mode that brain deals with images and speech. In the field of NLP, a topic model is one of the important ways for modeling documents. Topic models are built on a generative model that clearly does not match the way humans write. In this paper, we propose Event Model, which is unsupervised and based on the language processing mechanism of neurolinguistics, to model documents. In Event Model, documents are descriptions of concrete or abstract events seen, heard, or sensed by people and words are objects in the events. Event Model has two stages: word learning and dimensionality reduction. Word learning is to learn semantics of words based on deep learning. Dimensionality reduction is the process that representing a document as a low dimensional vector by a linear mode that is completely different from topic models. Event Model achieves state-of-the-art results on document retrieval tasks.

  7. Didactical modelling

    DEFF Research Database (Denmark)

    Højgaard, Tomas; Hansen, Rune

    The purpose of this paper is to introduce Didactical Modelling as a research methodology in mathematics education. We compare the methodology with other approaches and argue that Didactical Modelling has its own specificity. We discuss the methodological “why” and explain why we find it useful...... to construct this approach in mathematics education research....

  8. Virtual modeling

    NARCIS (Netherlands)

    Flores, J.; Kiss, S.; Cano, P.; Nijholt, Antinus; Zwiers, Jakob

    2003-01-01

    We concentrate our efforts on building virtual modelling environments where the content creator uses controls (widgets) as an interactive adjustment modality for the properties of the edited objects. Besides the advantage of being an on-line modelling approach (visualised just like any other on-line

  9. Animal models

    DEFF Research Database (Denmark)

    Gøtze, Jens Peter; Krentz, Andrew

    2014-01-01

    In this issue of Cardiovascular Endocrinology, we are proud to present a broad and dedicated spectrum of reviews on animal models in cardiovascular disease. The reviews cover most aspects of animal models in science from basic differences and similarities between small animals and the human...

  10. Education models

    NARCIS (Netherlands)

    Poortman, Sybilla; Sloep, Peter

    2006-01-01

    Educational models describes a case study on a complex learning object. Possibilities are investigated for using this learning object, which is based on a particular educational model, outside of its original context. Furthermore, this study provides advice that might lead to an increase in

  11. Modeling Sunspots

    Science.gov (United States)

    Oh, Phil Seok; Oh, Sung Jin

    2013-01-01

    Modeling in science has been studied by education researchers for decades and is now being applied broadly in school. It is among the scientific practices featured in the "Next Generation Science Standards" ("NGSS") (Achieve Inc. 2013). This article describes modeling activities in an extracurricular science club in a high…

  12. Battery Modeling

    NARCIS (Netherlands)

    Jongerden, M.R.; Haverkort, Boudewijn R.H.M.

    2008-01-01

    The use of mobile devices is often limited by the capacity of the employed batteries. The battery lifetime determines how long one can use a device. Battery modeling can help to predict, and possibly extend this lifetime. Many different battery models have been developed over the years. However,

  13. VENTILATION MODEL

    International Nuclear Information System (INIS)

    V. Chipman

    2002-01-01

    The purpose of the Ventilation Model is to simulate the heat transfer processes in and around waste emplacement drifts during periods of forced ventilation. The model evaluates the effects of emplacement drift ventilation on the thermal conditions in the emplacement drifts and surrounding rock mass, and calculates the heat removal by ventilation as a measure of the viability of ventilation to delay the onset of peak repository temperature and reduce its magnitude. The heat removal by ventilation is temporally and spatially dependent, and is expressed as the fraction of heat carried away by the ventilation air compared to the fraction of heat produced by radionuclide decay. One minus the heat removal is called the wall heat fraction, or the remaining amount of heat that is transferred via conduction to the surrounding rock mass. Downstream models, such as the ''Multiscale Thermohydrologic Model'' (BSC 2001), use the wall heat fractions as outputted from the Ventilation Model to initialize their postclosure analyses

  14. Modelling Constructs

    DEFF Research Database (Denmark)

    Kindler, Ekkart

    2009-01-01

    , these notations have been extended in order to increase expressiveness and to be more competitive. This resulted in an increasing number of notations and formalisms for modelling business processes and in an increase of the different modelling constructs provided by modelling notations, which makes it difficult......There are many different notations and formalisms for modelling business processes and workflows. These notations and formalisms have been introduced with different purposes and objectives. Later, influenced by other notations, comparisons with other tools, or by standardization efforts...... to compare modelling notations and to make transformations between them. One of the reasons is that, in each notation, the new concepts are introduced in a different way by extending the already existing constructs. In this chapter, we go the opposite direction: We show that it is possible to add most...

  15. OSPREY Model

    Energy Technology Data Exchange (ETDEWEB)

    Veronica J. Rutledge

    2013-01-01

    The absence of industrial scale nuclear fuel reprocessing in the U.S. has precluded the necessary driver for developing the advanced simulation capability now prevalent in so many other countries. Thus, it is essential to model complex series of unit operations to simulate, understand, and predict inherent transient behavior and feedback loops. A capability of accurately simulating the dynamic behavior of advanced fuel cycle separation processes will provide substantial cost savings and many technical benefits. The specific fuel cycle separation process discussed in this report is the off-gas treatment system. The off-gas separation consists of a series of scrubbers and adsorption beds to capture constituents of interest. Dynamic models are being developed to simulate each unit operation involved so each unit operation can be used as a stand-alone model and in series with multiple others. Currently, an adsorption model has been developed within Multi-physics Object Oriented Simulation Environment (MOOSE) developed at the Idaho National Laboratory (INL). Off-gas Separation and REcoverY (OSPREY) models the adsorption of off-gas constituents for dispersed plug flow in a packed bed under non-isothermal and non-isobaric conditions. Inputs to the model include gas, sorbent, and column properties, equilibrium and kinetic data, and inlet conditions. The simulation outputs component concentrations along the column length as a function of time from which breakthrough data is obtained. The breakthrough data can be used to determine bed capacity, which in turn can be used to size columns. It also outputs temperature along the column length as a function of time and pressure drop along the column length. Experimental data and parameters were input into the adsorption model to develop models specific for krypton adsorption. The same can be done for iodine, xenon, and tritium. The model will be validated with experimental breakthrough curves. Customers will be given access to

  16. Modeling Applications.

    Science.gov (United States)

    McMEEKIN, Thomas A; Ross, Thomas

    1996-12-01

    The concept of predictive microbiology has developed rapidly through the initial phases of experimental design and model development and the subsequent phase of model validation. A fully validated model represents a general rule which may be brought to bear on particular cases. For some microorganism/food combinations, sufficient confidence now exists to indicate substantial benefits to the food industry from use of predictive models. Several types of devices are available to monitor and record environmental conditions (particularly temperature). These "environmental histories" can be interpreted, using predictive models, in terms of microbial proliferation. The current challenge is to provide systems for the collection and interpretation of environmental information which combine ease of use, reliability, and security, providing the industrial user with the ability to make informed and precise decisions regarding the quality and safety of foods. Many specific applications for predictive modeling can be developed from a basis of understanding the inherent qualities of a fully validated model. These include increased precision and confidence in predictions based on accumulation of quantitative data, objective and rapid assessment of the effect of environmental conditions on microbial proliferation, and flexibility in monitoring the relative contribution of component parts of processing, distribution, and storage systems for assurance of shelf life and safety.

  17. A Model for Math Modeling

    Science.gov (United States)

    Lin, Tony; Erfan, Sasan

    2016-01-01

    Mathematical modeling is an open-ended research subject where no definite answers exist for any problem. Math modeling enables thinking outside the box to connect different fields of studies together including statistics, algebra, calculus, matrices, programming and scientific writing. As an integral part of society, it is the foundation for many…

  18. Modeling complexes of modeled proteins.

    Science.gov (United States)

    Anishchenko, Ivan; Kundrotas, Petras J; Vakser, Ilya A

    2017-03-01

    Structural characterization of proteins is essential for understanding life processes at the molecular level. However, only a fraction of known proteins have experimentally determined structures. This fraction is even smaller for protein-protein complexes. Thus, structural modeling of protein-protein interactions (docking) primarily has to rely on modeled structures of the individual proteins, which typically are less accurate than the experimentally determined ones. Such "double" modeling is the Grand Challenge of structural reconstruction of the interactome. Yet it remains so far largely untested in a systematic way. We present a comprehensive validation of template-based and free docking on a set of 165 complexes, where each protein model has six levels of structural accuracy, from 1 to 6 Å C α RMSD. Many template-based docking predictions fall into acceptable quality category, according to the CAPRI criteria, even for highly inaccurate proteins (5-6 Å RMSD), although the number of such models (and, consequently, the docking success rate) drops significantly for models with RMSD > 4 Å. The results show that the existing docking methodologies can be successfully applied to protein models with a broad range of structural accuracy, and the template-based docking is much less sensitive to inaccuracies of protein models than the free docking. Proteins 2017; 85:470-478. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  19. RNICE Model

    DEFF Research Database (Denmark)

    Pedersen, Mogens Jin; Stritch, Justin Michael

    2018-01-01

    contributes knowledge about a social phenomenon and advances knowledge in the public administration and management literatures. The RNICE model provides a vehicle for researchers who seek to evaluate or demonstrate the value of a replication study systematically. We illustrate the practical application...... research. Recently, scholars have issued calls for more replication, but academic reflections on when replication adds substantive value to public administration and management research are needed. This concise article presents a conceptual model, RNICE, for assessing when and how a replication study...... of the model using two previously published replication studies as examples....

  20. Correct Models

    OpenAIRE

    Blacher, René

    2010-01-01

    Ce rapport complete les deux rapports précédents et apporte une explication plus simple aux résultats précédents : à savoir la preuve que les suites obtenues sont aléatoires.; In previous reports, we have show how to transform a text $y_n$ in a random sequence by using functions of Fibonacci $T_q$. Now, in this report, we obtain a clearer result by proving that $T_q(y_n)$ has the IID model as correct model. But, it is necessary to define correctly a correct model. Then, we study also this pro...

  1. Paleoclimate Modeling

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Computer simulations of past climate. Variables provided as model output are described by parameter keyword. In some cases the parameter keywords are a subset of all...

  2. Anchor Modeling

    Science.gov (United States)

    Regardt, Olle; Rönnbäck, Lars; Bergholtz, Maria; Johannesson, Paul; Wohed, Petia

    Maintaining and evolving data warehouses is a complex, error prone, and time consuming activity. The main reason for this state of affairs is that the environment of a data warehouse is in constant change, while the warehouse itself needs to provide a stable and consistent interface to information spanning extended periods of time. In this paper, we propose a modeling technique for data warehousing, called anchor modeling, that offers non-destructive extensibility mechanisms, thereby enabling robust and flexible management of changes in source systems. A key benefit of anchor modeling is that changes in a data warehouse environment only require extensions, not modifications, to the data warehouse. This ensures that existing data warehouse applications will remain unaffected by the evolution of the data warehouse, i.e. existing views and functions will not have to be modified as a result of changes in the warehouse model.

  3. Linear Models

    CERN Document Server

    Searle, Shayle R

    2012-01-01

    This 1971 classic on linear models is once again available--as a Wiley Classics Library Edition. It features material that can be understood by any statistician who understands matrix algebra and basic statistical methods.

  4. Environmental Modeling

    Science.gov (United States)

    EPA's modeling community is working to gain insights into certain parts of a physical, biological, economic, or social system by conducting environmental assessments for Agency decision making to complex environmental issues.

  5. Quark models

    International Nuclear Information System (INIS)

    Rosner, J.L.

    1981-01-01

    This paper invites experimenters to consider the wide variety of tests suggested by the new aspects of quark models since the discovery of charm and beauty, and nonrelativistic models. Colors and flavours are counted and combined into hadrons. The current quark zoo is summarized. Models and theoretical background are studied under: qualitative QCD: strings and bags, potential models, relativistic effects, electromagnetic transitions, gluon emissions, and single quark transition descriptions. Hadrons containing quarks known before 1974 (i.e. that can be made of ''light'' quarks u, d, and s) are treated in Section III, while those containing charmed quarks and beauty (b) quarks are discussed in Section IV. Unfolding the properties of the sixth quark from information on its hadrons is seen as a future application of the methods used in this study

  6. Model theory

    CERN Document Server

    Hodges, Wilfrid

    1993-01-01

    An up-to-date and integrated introduction to model theory, designed to be used for graduate courses (for students who are familiar with first-order logic), and as a reference for more experienced logicians and mathematicians.

  7. Numerical models

    Digital Repository Service at National Institute of Oceanography (India)

    Unnikrishnan, A.S.; Manoj, N.T.

    developed most of the above models. This is a good approximation to simulate horizontal distribution of active and passive variables. The future challenge lies in developing capability to simulate the distribution in the vertical....

  8. Composite models

    International Nuclear Information System (INIS)

    Peccei, R.D.

    If quarks and leptons are composite, it should be possible eventually to calculate their mass spectrum and understand the reasons for the observed family replications, questions which lie beyond the standard model. Alas, all experimental evidence to date points towards quark and lepton elemenarity with the typical momentum scale Λsub(comp), beyond which effects of inner structure may be seen, probably being greater than ITeV. One supersymmetric preon model explained provides a new dynamical alternative for obtaining light fermions which is that these states are quasi Goldstone fermions. This, and similar models are discussed. Although quasi Goldstone fermions provide an answer to the 0sup(th)-order question of composite models the questions of how masses and families are generated remain unanswered. (U.K.)

  9. Measuring the performance of FCM versus PSO for fuzzy clustering problems

    Directory of Open Access Journals (Sweden)

    Amir Reza Soltani

    2013-06-01

    Full Text Available Clustering cellular manufacturing plays an important role in many industrial engineering problems. This paper investigates the performance of two methods of heuristic and metaheuristics fuzzy clustering. The proposed method investigates heuristic well-known FCM and particle swarm optimization (PSO on some well-known benchmarks. We use two criteria of J(P as well as Xie-Beni to compare the results. Three parameters of PSO method is tuned using design of experiment and then the results of PSO are compared versus FCM method in terms of two mentioned criteria. The proposed models are run for each instance 10 different times and, using ANOVA test, the means of two methods are compared. While the results of ANOVA do not indicate any meaningful difference between PSO and FCM in terms of J(P, we have found some meaningful differences between PSO and FCM in terms of Xie-Beni criterion. In other words, PSO performs better than FCM in terms of Xie-Beni.

  10. Ventilation models

    Science.gov (United States)

    Skaaret, Eimund

    Calculation procedures, used in the design of ventilating systems, which are especially suited for displacement ventilation in addition to linking it to mixing ventilation, are addressed. The two zone flow model is considered and the steady state and transient solutions are addressed. Different methods of supplying air are discussed, and different types of air flow are considered: piston flow, plane flow and radial flow. An evaluation model for ventilation systems is presented.

  11. Maturity Models

    DEFF Research Database (Denmark)

    Lasrado, Lester Allan; Vatrapu, Ravi

    2016-01-01

    effects, unicausal reduction, and case specificity. Based on the developments in set theoretical thinking in social sciences and employing methods like Qualitative Comparative Analysis (QCA), Necessary Condition Analysis (NCA), and set visualization techniques, in this position paper, we propose...... and demonstrate a new approach to maturity models in the domain of Information Systems. This position paper describes the set-theoretical approach to maturity models, presents current results and outlines future research work....

  12. Accelerated life models modeling and statistical analysis

    CERN Document Server

    Bagdonavicius, Vilijandas

    2001-01-01

    Failure Time DistributionsIntroductionParametric Classes of Failure Time DistributionsAccelerated Life ModelsIntroductionGeneralized Sedyakin's ModelAccelerated Failure Time ModelProportional Hazards ModelGeneralized Proportional Hazards ModelsGeneralized Additive and Additive-Multiplicative Hazards ModelsChanging Shape and Scale ModelsGeneralizationsModels Including Switch-Up and Cycling EffectsHeredity HypothesisSummaryAccelerated Degradation ModelsIntroductionDegradation ModelsModeling the Influence of Explanatory Varia

  13. Model uncertainty: Probabilities for models?

    International Nuclear Information System (INIS)

    Winkler, R.L.

    1994-01-01

    Like any other type of uncertainty, model uncertainty should be treated in terms of probabilities. The question is how to do this. The most commonly-used approach has a drawback related to the interpretation of the probabilities assigned to the models. If we step back and look at the big picture, asking what the appropriate focus of the model uncertainty question should be in the context of risk and decision analysis, we see that a different probabilistic approach makes more sense, although it raise some implementation questions. Current work that is underway to address these questions looks very promising

  14. Mechanistic models

    Energy Technology Data Exchange (ETDEWEB)

    Curtis, S.B.

    1990-09-01

    Several models and theories are reviewed that incorporate the idea of radiation-induced lesions (repairable and/or irreparable) that can be related to molecular lesions in the DNA molecule. Usually the DNA double-strand or chromatin break is suggested as the critical lesion. In the models, the shoulder on the low-LET survival curve is hypothesized as being due to one (or more) of the following three mechanisms: (1) ``interaction`` of lesions produced by statistically independent particle tracks; (2) nonlinear (i.e., linear-quadratic) increase in the yield of initial lesions, and (3) saturation of repair processes at high dose. Comparisons are made between the various approaches. Several significant advances in model development are discussed; in particular, a description of the matrix formulation of the Markov versions of the RMR and LPL models is given. The more advanced theories have incorporated statistical fluctuations in various aspects of the energy-loss and lesion-formation process. An important direction is the inclusion of physical and chemical processes into the formulations by incorporating relevant track structure theory (Monte Carlo track simulations) and chemical reactions of radiation-induced radicals. At the biological end, identification of repair genes and how they operate as well as a better understanding of how DNA misjoinings lead to lethal chromosome aberrations are needed for appropriate inclusion into the theories. More effort is necessary to model the complex end point of radiation-induced carcinogenesis.

  15. Mechanistic models

    Energy Technology Data Exchange (ETDEWEB)

    Curtis, S.B.

    1990-09-01

    Several models and theories are reviewed that incorporate the idea of radiation-induced lesions (repairable and/or irreparable) that can be related to molecular lesions in the DNA molecule. Usually the DNA double-strand or chromatin break is suggested as the critical lesion. In the models, the shoulder on the low-LET survival curve is hypothesized as being due to one (or more) of the following three mechanisms: (1) interaction'' of lesions produced by statistically independent particle tracks; (2) nonlinear (i.e., linear-quadratic) increase in the yield of initial lesions, and (3) saturation of repair processes at high dose. Comparisons are made between the various approaches. Several significant advances in model development are discussed; in particular, a description of the matrix formulation of the Markov versions of the RMR and LPL models is given. The more advanced theories have incorporated statistical fluctuations in various aspects of the energy-loss and lesion-formation process. An important direction is the inclusion of physical and chemical processes into the formulations by incorporating relevant track structure theory (Monte Carlo track simulations) and chemical reactions of radiation-induced radicals. At the biological end, identification of repair genes and how they operate as well as a better understanding of how DNA misjoinings lead to lethal chromosome aberrations are needed for appropriate inclusion into the theories. More effort is necessary to model the complex end point of radiation-induced carcinogenesis.

  16. Reflectance Modeling

    Science.gov (United States)

    Smith, J. A.; Cooper, K.; Randolph, M.

    1984-01-01

    A classical description of the one dimensional radiative transfer treatment of vegetation canopies was completed and the results were tested against measured prairie (blue grama) and agricultural canopies (soybean). Phase functions are calculated in terms of directly measurable biophysical characteristics of the canopy medium. While the phase functions tend to exhibit backscattering anisotropy, their exact behavior is somewhat more complex and wavelength dependent. A Monte Carlo model was developed that treats soil surfaces with large periodic variations in three dimensions. A photon-ray tracing technology is used. Currently, the rough soil surface is described by analytic functions and appropriate geometric calculations performed. A bidirectional reflectance distribution function is calculated and, hence, available for other atmospheric or canopy reflectance models as a lower boundary condition. This technique is used together with an adding model to calculate several cases where Lambertian leaves possessing anisotropic leaf angle distributions yield non-Lambertian reflectance; similar behavior is exhibited for simulated soil surfaces.

  17. Mathematical modeling

    CERN Document Server

    Eck, Christof; Knabner, Peter

    2017-01-01

    Mathematical models are the decisive tool to explain and predict phenomena in the natural and engineering sciences. With this book readers will learn to derive mathematical models which help to understand real world phenomena. At the same time a wealth of important examples for the abstract concepts treated in the curriculum of mathematics degrees are given. An essential feature of this book is that mathematical structures are used as an ordering principle and not the fields of application. Methods from linear algebra, analysis and the theory of ordinary and partial differential equations are thoroughly introduced and applied in the modeling process. Examples of applications in the fields electrical networks, chemical reaction dynamics, population dynamics, fluid dynamics, elasticity theory and crystal growth are treated comprehensively.

  18. Modelling language

    CERN Document Server

    Cardey, Sylviane

    2013-01-01

    In response to the need for reliable results from natural language processing, this book presents an original way of decomposing a language(s) in a microscopic manner by means of intra/inter‑language norms and divergences, going progressively from languages as systems to the linguistic, mathematical and computational models, which being based on a constructive approach are inherently traceable. Languages are described with their elements aggregating or repelling each other to form viable interrelated micro‑systems. The abstract model, which contrary to the current state of the art works in int

  19. Molecular modeling

    Directory of Open Access Journals (Sweden)

    Aarti Sharma

    2009-01-01

    Full Text Available The use of computational chemistry in the development of novel pharmaceuticals is becoming an increasingly important tool. In the past, drugs were simply screened for effectiveness. The recent advances in computing power and the exponential growth of the knowledge of protein structures have made it possible for organic compounds to be tailored to decrease the harmful side effects and increase the potency. This article provides a detailed description of the techniques employed in molecular modeling. Molecular modeling is a rapidly developing discipline, and has been supported by the dramatic improvements in computer hardware and software in recent years.

  20. Supernova models

    International Nuclear Information System (INIS)

    Woosley, S.E.; Weaver, T.A.

    1980-01-01

    Recent progress in understanding the observed properties of Type I supernovae as a consequence of the thermonuclear detonation of white dwarf stars and the ensuing decay of the 56 Ni produced therein is reviewed. Within the context of this model for Type I explosions and the 1978 model for Type II explosions, the expected nucleosynthesis and gamma-line spectra from both kinds of supernovae are presented. Finally, a qualitatively new approach to the problem of massive star death and Type II supernovae based upon a combination of rotation and thermonuclear burning is discussed

  1. Cadastral Modeling

    DEFF Research Database (Denmark)

    Stubkjær, Erik

    2005-01-01

    to the modeling of an industrial sector, as it aims at rendering the basic concepts that relate to the domain of real estate and the pertinent human activities. The palpable objects are pieces of land and buildings, documents, data stores and archives, as well as persons in their diverse roles as owners, holders...... to land. The paper advances the position that cadastral modeling has to include not only the physical objects, agents, and information sets of the domain, but also the objectives or requirements of cadastral systems....

  2. (SSE) model

    African Journals Online (AJOL)

    Simple analytic polynomials have been proposed for estimating solar radiation in the traditional Northern, Central and Southern regions of Malawi. There is a strong agreement between the polynomials and the SSE model with R2 values of 0.988, 0.989 and 0.989 and root mean square errors of 0.061, 0.057 and 0.062 ...

  3. Lens Model

    DEFF Research Database (Denmark)

    Nash, Ulrik William

    2014-01-01

    Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory...

  4. Markov model

    Indian Academy of Sciences (India)

    pattern of the watershed LULC, leading to an accretive linear growth of agricultural and settlement areas. The annual rate of ... thereby advocates for better agricultural practices with additional energy subsidy to arrest further forest loss and LULC ...... automaton model and GIS: Long-term urban growth pre- diction for San ...

  5. Cheating models

    DEFF Research Database (Denmark)

    Arnoldi, Jakob

    The article discusses the use of algorithmic models for so-called High Frequency Trading (HFT) in finance. HFT is controversial yet widespread in modern financial markets. It is a form of automated trading technology which critics among other things claim can lead to market manipulation. Drawing ...

  6. Entrepreneurship Models.

    Science.gov (United States)

    Finger Lakes Regional Education Center for Economic Development, Mount Morris, NY.

    This guide describes seven model programs that were developed by the Finger Lakes Regional Center for Economic Development (New York) to meet the training needs of female and minority entrepreneurs to help their businesses survive and grow and to assist disabled and dislocated workers and youth in beginning small businesses. The first three models…

  7. The Model

    DEFF Research Database (Denmark)

    About the reconstruction of Palle Nielsen's (f. 1942) work The Model from 1968: a gigantic playground for children in the museum, where they can freely romp about, climb in ropes, crawl on wooden structures, work with tools, jump in foam rubber, paint with finger paints and dress up in costumes....

  8. Model Checking

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 7. Model Checking - Automated Verification of Computational Systems. Madhavan Mukund. General Article Volume 14 Issue 7 July 2009 pp 667-681. Fulltext. Click here to view fulltext PDF. Permanent link:

  9. Successful modeling?

    Science.gov (United States)

    Lomnitz, Cinna

    Tichelaar and Ruff [1989] propose to “estimate model variance in complicated geophysical problems,” including the determination of focal depth in earthquakes, by means of unconventional statistical methods such as bootstrapping. They are successful insofar as they are able to duplicate the results from more conventional procedures.

  10. Molecular Modeling

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 9; Issue 5. Molecular Modeling: A Powerful Tool for Drug Design and Molecular Docking. Rama Rao Nadendla. General Article Volume 9 Issue 5 May 2004 pp 51-60. Fulltext. Click here to view fulltext PDF. Permanent link:

  11. Turbulence Model

    DEFF Research Database (Denmark)

    Nielsen, Mogens Peter; Shui, Wan; Johansson, Jens

    2011-01-01

    term with stresses depending linearly on the strain rates. This term takes into account the transfer of linear momentum from one part of the fluid to another. Besides there is another term, which takes into account the transfer of angular momentum. Thus the model implies a new definition of turbulence...

  12. Model-reduced inverse modeling

    NARCIS (Netherlands)

    Vermeulen, P.T.M.

    2006-01-01

    Although faster computers have been developed in recent years, they tend to be used to solve even more detailed problems. In many cases this will yield enormous models that can not be solved within acceptable time constraints. Therefore, there is a need for alternative methods that simulate such

  13. Building Models and Building Modelling

    DEFF Research Database (Denmark)

    Jørgensen, Kaj; Skauge, Jørn

    2008-01-01

    I rapportens indledende kapitel beskrives de primære begreber vedrørende bygningsmodeller og nogle fundamentale forhold vedrørende computerbaseret modulering bliver opstillet. Desuden bliver forskellen mellem tegneprogrammer og bygnings­model­lerings­programmer beskrevet. Vigtige aspekter om comp...

  14. Molecular Modelling

    Directory of Open Access Journals (Sweden)

    Aarti Sharma

    2009-12-01

    Full Text Available

    The use of computational chemistry in the development of novel pharmaceuticals is becoming an increasingly important
    tool. In the past, drugs were simply screened for effectiveness. The recent advances in computing power and
    the exponential growth of the knowledge of protein structures have made it possible for organic compounds to tailored to
    decrease harmful side effects and increase the potency. This article provides a detailed description of the techniques
    employed in molecular modeling. Molecular modelling is a rapidly developing discipline, and has been supported from
    the dramatic improvements in computer hardware and software in recent years.

  15. Acyclic models

    CERN Document Server

    Barr, Michael

    2002-01-01

    Acyclic models is a method heavily used to analyze and compare various homology and cohomology theories appearing in topology and algebra. This book is the first attempt to put together in a concise form this important technique and to include all the necessary background. It presents a brief introduction to category theory and homological algebra. The author then gives the background of the theory of differential modules and chain complexes over an abelian category to state the main acyclic models theorem, generalizing and systemizing the earlier material. This is then applied to various cohomology theories in algebra and topology. The volume could be used as a text for a course that combines homological algebra and algebraic topology. Required background includes a standard course in abstract algebra and some knowledge of topology. The volume contains many exercises. It is also suitable as a reference work for researchers.

  16. RNICE Model

    DEFF Research Database (Denmark)

    Pedersen, Mogens Jin; Stritch, Justin Michael

    2018-01-01

    Replication studies relate to the scientific principle of replicability and serve the significant purpose of providing supporting (or contradicting) evidence regarding the existence of a phenomenon. However, replication has never been an integral part of public administration and management...... research. Recently, scholars have issued calls for more replication, but academic reflections on when replication adds substantive value to public administration and management research are needed. This concise article presents a conceptual model, RNICE, for assessing when and how a replication study...... contributes knowledge about a social phenomenon and advances knowledge in the public administration and management literatures. The RNICE model provides a vehicle for researchers who seek to evaluate or demonstrate the value of a replication study systematically. We illustrate the practical application...

  17. Persistent Modelling

    DEFF Research Database (Denmark)

    2012-01-01

    on this subject, this book makes essential reading for anyone considering new ways of thinking about architecture. In drawing upon both historical and contemporary perspectives this book provides evidence of the ways in which relations between representation and the represented continue to be reconsidered......The relationship between representation and the represented is examined here through the notion of persistent modelling. This notion is not novel to the activity of architectural design if it is considered as describing a continued active and iterative engagement with design concerns – an evident...... characteristic of architectural practice. But the persistence in persistent modelling can also be understood to apply in other ways, reflecting and anticipating extended roles for representation. This book identifies three principle areas in which these extensions are becoming apparent within contemporary...

  18. Persistent Modelling

    DEFF Research Database (Denmark)

    on this subject, this book makes essential reading for anyone considering new ways of thinking about architecture. In drawing upon both historical and contemporary perspectives this book provides evidence of the ways in which relations between representation and the represented continue to be reconsidered......The relationship between representation and the represented is examined here through the notion of persistent modelling. This notion is not novel to the activity of architectural design if it is considered as describing a continued active and iterative engagement with design concerns – an evident...... characteristic of architectural practice. But the persistence in persistent modelling can also be understood to apply in other ways, reflecting and anticipating extended roles for representation. This book identifies three principle areas in which these extensions are becoming apparent within contemporary...

  19. Modeling Minds

    DEFF Research Database (Denmark)

    Michael, John

    others' minds. Then (2), in order to bring to light some possible justifications, as well as hazards and criticisms of the methodology of looking time tests, I will take a closer look at the concept of folk psychology and will focus on the idea that folk psychology involves using oneself as a model...... of other people in order to predict and understand their behavior. Finally (3), I will discuss the historical location and significance of the emergence of looking time tests...

  20. Hydroballistics Modeling

    Science.gov (United States)

    1975-01-01

    detailed rendered visible in his photographs by streams of photographs of spheres entering the water small bubbles from electrolysis . So far as is...of the cavity is opaque or, brined wihile the sphere wats still in the oil. At if translucent, the contrast between thle jet and about the time the...and brass, for example) should be so model velocity scale according to Equation 1.18, selected that electrolysis is not a problem. the addition of

  1. Biomimetic modelling.

    OpenAIRE

    Vincent, Julian F V

    2003-01-01

    Biomimetics is seen as a path from biology to engineering. The only path from engineering to biology in current use is the application of engineering concepts and models to biological systems. However, there is another pathway: the verification of biological mechanisms by manufacture, leading to an iterative process between biology and engineering in which the new understanding that the engineering implementation of a biological system can bring is fed back into biology, allowing a more compl...

  2. Modelling Behaviour

    DEFF Research Database (Denmark)

    This book reflects and expands on the current trend in the building industry to understand, simulate and ultimately design buildings by taking into consideration the interlinked elements and forces that act on them. This approach overcomes the traditional, exclusive focus on building tasks, while....... The chapter authors were invited speakers at the 5th Symposium "Modelling Behaviour", which took place at the CITA in Copenhagen in September 2015....

  3. Combustor Modelling

    Science.gov (United States)

    1980-02-01

    a teuto 014aceo 0-oiuato 4 ajj 210- I 14 *Experiments l~~lamCID - l2 C15 model+ Aida ditane &Gray medium K .2 a Experiments hont target n-IO a0 deawa...possibilita di valutazione dello scambio termico in focolai di caldaie per ricaldamento"I Atti E Rassegna Tecnica Societa ingegneri e arc~hitetti in Torino

  4. Persistent Modelling

    DEFF Research Database (Denmark)

    practice: the duration of active influence that representation can hold in relation to the represented; the means, methods and media through which representations are constructed and used; and what it is that is being represented. Featuring contributions from some of the world’s most advanced thinkers....... It also provides critical insight into the use of contemporary modelling tools and methods, together with an examination of the implications their use has within the territories of architectural design, realisation and experience....

  5. Ozone modeling

    International Nuclear Information System (INIS)

    McIllvaine, C.M.

    1994-01-01

    Exhaust gases from power plants that burn fossil fuels contain concentrations of sulfur dioxide (SO 2 ), nitric oxide (NO), particulate matter, hydrocarbon compounds and trace metals. Estimated emissions from the operation of a hypothetical 500 MW coal-fired power plant are given. Ozone is considered a secondary pollutant, since it is not emitted directly into the atmosphere but is formed from other air pollutants, specifically, nitrogen oxides (NO), and non-methane organic compounds (NMOQ) in the presence of sunlight. (NMOC are sometimes referred to as hydrocarbons, HC, or volatile organic compounds, VOC, and they may or may not include methane). Additionally, ozone formation Alternative is a function of the ratio of NMOC concentrations to NO x concentrations. A typical ozone isopleth is shown, generated with the Empirical Kinetic Modeling Approach (EKMA) option of the Environmental Protection Agency's (EPA) Ozone Isopleth Plotting Mechanism (OZIPM-4) model. Ozone isopleth diagrams, originally generated with smog chamber data, are more commonly generated with photochemical reaction mechanisms and tested against smog chamber data. The shape of the isopleth curves is a function of the region (i.e. background conditions) where ozone concentrations are simulated. The location of an ozone concentration on the isopleth diagram is defined by the ratio of NMOC and NO x coordinates of the point, known as the NMOC/NO x ratio. Results obtained by the described model are presented

  6. Modeling biomembranes.

    Energy Technology Data Exchange (ETDEWEB)

    Plimpton, Steven James; Heffernan, Julieanne; Sasaki, Darryl Yoshio; Frischknecht, Amalie Lucile; Stevens, Mark Jackson; Frink, Laura J. Douglas

    2005-11-01

    Understanding the properties and behavior of biomembranes is fundamental to many biological processes and technologies. Microdomains in biomembranes or ''lipid rafts'' are now known to be an integral part of cell signaling, vesicle formation, fusion processes, protein trafficking, and viral and toxin infection processes. Understanding how microdomains form, how they depend on membrane constituents, and how they act not only has biological implications, but also will impact Sandia's effort in development of membranes that structurally adapt to their environment in a controlled manner. To provide such understanding, we created physically-based models of biomembranes. Molecular dynamics (MD) simulations and classical density functional theory (DFT) calculations using these models were applied to phenomena such as microdomain formation, membrane fusion, pattern formation, and protein insertion. Because lipid dynamics and self-organization in membranes occur on length and time scales beyond atomistic MD, we used coarse-grained models of double tail lipid molecules that spontaneously self-assemble into bilayers. DFT provided equilibrium information on membrane structure. Experimental work was performed to further help elucidate the fundamental membrane organization principles.

  7. Object Modeling and Building Information Modeling

    OpenAIRE

    Auråen, Hege; Gjemdal, Hanne

    2016-01-01

    The main part of this thesis is an online course (Small Private Online Course) entitled "Introduction to Object Modeling and Building Information Modeling". This supplementary report clarifies the choices made in the process of developing the course. The course examines the basic concepts of object modeling, modeling techniques and a modeling language ​​(UML). Further, building information modeling (BIM) is presented as a modeling process, and the object modeling concepts in the BIM softw...

  8. DTN Modeling in OPNET Modeler

    Directory of Open Access Journals (Sweden)

    PAPAJ Jan

    2014-05-01

    Full Text Available Traditional wireless networks use the concept of the point-to-point forwarding inherited from reliable wired networks which seems to be not ideal for wireless environment. New emerging applications and networks operate mostly disconnected. So-called Delay-Tolerant networks (DTNs are receiving increasing attentions from both academia and industry. DTNs introduced a store-carry-and-forward concept solving the problem of intermittent connectivity. Behavior of such networks is verified by real models, computer simulation or combination of the both approaches. Computer simulation has become the primary and cost effective tool for evaluating the performance of the DTNs. OPNET modeler is our target simulation tool and we wanted to spread OPNET’s simulation opportunity towards DTN. We implemented bundle protocol to OPNET modeler allowing simulate cases based on bundle concept as epidemic forwarding which relies on flooding the network with messages and the forwarding algorithm based on the history of past encounters (PRoPHET. The implementation details will be provided in article.

  9. Model integration and a theory of models

    OpenAIRE

    Dolk, Daniel R.; Kottemann, Jeffrey E.

    1993-01-01

    Model integration extends the scope of model management to include the dimension of manipulation as well. This invariably leads to comparisons with database theory. Model integration is viewed from four perspectives: Organizational, definitional, procedural, and implementational. Strategic modeling is discussed as the organizational motivation for model integration. Schema and process integration are examined as the logical and manipulation counterparts of model integr...

  10. Model Checking Algorithms for Markov Reward Models

    NARCIS (Netherlands)

    Cloth, Lucia; Cloth, L.

    2006-01-01

    Model checking Markov reward models unites two different approaches of model-based system validation. On the one hand, Markov reward models have a long tradition in model-based performance and dependability evaluation. On the other hand, a formal method like model checking allows for the precise

  11. Modelling Defiguration

    DEFF Research Database (Denmark)

    Bork Petersen, Franziska

    2013-01-01

    focus centres on how the catwalk scenography evokes a ‘defiguration’ of the walking models and to what effect. Vibskov’s mobile catwalk draws attention to the walk, which is a key element of models’ performance but which usually functions in fashion shows merely to present clothes in the most...... catwalks. Vibskov’s catwalk induces what the dance scholar Gabriele Brandstetter has labelled a ‘defigurative choregoraphy’: a straying from definitions, which exist in ballet as in other movement-based genres, of how a figure should move and appear (1998). The catwalk scenography in this instance...

  12. Students' Models of Curve Fitting: A Models and Modeling Perspective

    Science.gov (United States)

    Gupta, Shweta

    2010-01-01

    The Models and Modeling Perspectives (MMP) has evolved out of research that began 26 years ago. MMP researchers use Model Eliciting Activities (MEAs) to elicit students' mental models. In this study MMP was used as the conceptual framework to investigate the nature of students' models of curve fitting in a problem-solving environment consisting of…

  13. ALEPH model

    CERN Multimedia

    1989-01-01

    A wooden model of the ALEPH experiment and its cavern. ALEPH was one of 4 experiments at CERN's 27km Large Electron Positron collider (LEP) that ran from 1989 to 2000. During 11 years of research, LEP's experiments provided a detailed study of the electroweak interaction. Measurements performed at LEP also proved that there are three – and only three – generations of particles of matter. LEP was closed down on 2 November 2000 to make way for the construction of the Large Hadron Collider in the same tunnel. The cavern and detector are in separate locations - the cavern is stored at CERN and the detector is temporarily on display in Glasgow physics department. Both are available for loan.

  14. SOS regulatory elements are essential for UPEC pathogenesis.

    Science.gov (United States)

    Li, Birong; Smith, Peter; Horvath, Dennis J; Romesberg, Floyd E; Justice, Sheryl S

    2010-08-01

    Epithelial cells are highly regarded as the first line of defense against microorganisms, but the mechanisms used to control bacterial diseases are poorly understood. A component of the DNA damage repair regulon, SulA, is essential for UPEC virulence in a mouse model for human urinary tract infection, suggesting that DNA damage is a key mediator in the primary control of pathogens within the epithelium. In this study, we examine the role of DNA damage repair regulators in the intracellular lifestyle of UPEC within superficial bladder epithelial cells. LexA and RecA coordinate various operons for repair of DNA damage due to exogenous and endogenous agents and are known regulators of sulA. UPEC strains defective in regulation of the SOS response mediated by RecA and LexA display attenuated virulence in immunocompetent mice within the first 6 h post infection. RecA and LexA regulation of the SOS regulon is dispensable in immunocompromised mice. These data suggest that epithelial cells produce sufficient levels of DNA damaging agents, such that the bacterial DNA damage repair response is essential, as a means to control invading bacteria. Since many pathogens interact with the epithelium before exposure to professional phagocytes, it is likely that adaptation to oxidative radicals during intracellular growth provides additional protection from killing by innate immune phagocytes. Copyright 2010 Elsevier Masson SAS. All rights reserved.

  15. Surface roughness and morphology of three nanocomposites after two different polishing treatments by a multitechnique approach.

    Science.gov (United States)

    Janus, J; Fauxpoint, G; Arntz, Y; Pelletier, H; Etienne, O

    2010-05-01

    The purpose of this study was to assess the surface roughness and morphology of three nanocomposites polished with two different polishing systems. Specimens made of hybrid composite (Tetric Ceram [TC] as control) and nanocomposites: nanofilled (Filtek Supreme [FS]), nanofilled hybrid (Grandio [Gr]), complex nanofilled hybrid (Synergy D6 [Syn]) were polished with CompoSystem [CS] or Sof-Lex [SL] polishing discs. The average surface roughness (Ra) before and after polishing was measured using optical profilometry. Both AFM and SEM techniques were additionally used to analyze the surface morphology after polishing with the aim of relating the surface morphology and the surface roughness. Statistical analysis was done by ANOVA using a general linear model (alpha=0.05) with an adjustment for multiple comparisons. Within the same polishing system, FS exhibited the smoothest surface, followed by Syn, TC and Gr (p<0.0001). Sof-Lex polishing discs produced the smoothest surface compared to CompoSystem (p<0.0001). AFM and SEM observations confirmed that the surface roughness was related to the surface morphology and to the average filler size. Positive correlation between the average filler size and the surface roughness suggest that using nanoparticles in the formulation does not necessary improve the surface texture. The nanofilled composite FS, which contains only nanofillers, showed the best results when associated to Sof-Lex polishing discs. 2010 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  16. Use of ARM observations and numerical models to determine radiative and latent heating profiles of mesoscale convective systems for general circulation models

    Energy Technology Data Exchange (ETDEWEB)

    Tao, Wei-Kuo; Houze, Robert, A., Jr.; Zeng, Xiping

    2013-03-14

    submitted in September 2012. The major highlights are as follows: a. The results indicate that NU-WRF model could capture observed diurnal variation of rainfall (composite not individual); b. NU-WRF model could simulate two different types (propagating and local type) of the diurnal variation of rainfall; c. NU-WRF model simulation show very good agreement with observation in terms of precipitation pattern (linear MCS), radar reflectivity (a second low peak shallow convection); d. NU-WRF model simulation indicates that the cool-pool dynamic is the main physical process for MCS propagation speed; e. Surface heat fluxes (including land surface model and initial surface condition) do not play a major role in phase of diurnal variation (change rainfall amount slightly); f. Terrain effect is important for initial stage of MCS (rainfall is increased and close to observation by increasing the terrain height that is also close to observed); g. Diurnal variation of radiation is not important for the simulated variation of rainfall. Publications: Zeng, X., W.-K. Tao, S. Powell, R. Houze, Jr., P. Ciesielski, N. Guy, H. Pierce and T. Matsui, 2012: A comparison of the water budgets between clouds from AMMA and TWP-ICE. J. Atmos. Sci., 70, 487-503. Powell, S. W., R. A. Houze, Jr., A. Kumar, and S. A. McFarlane, 2012: Comparison of simulated and observed continental tropical anvil clouds and their radiative heating profiles. J. Atmos. Sci., 69, 2662-2681. Zeng, X., W.-K. Tao, T. Matsui, S. Xie, S. Lang, M. Zhang, D. Starr, and X. Li, 2011: Estimating the Ice Crystal Enhancement Factor in the Tropics. J. Atmos. Sci., 68, 1424-1434. Conferences: Zeng, X., W.-K. Tao, S. Powell, R. Houze, Jr., P. Ciesielski, N. Guy, H. Pierce and T. Matsui, 2012: Comparison of water budget between AMMA and TWP-ICE clouds. The 3rd Annual ASR Science Team Meeting. Arlington, Virginia, Mar. 12-16, 2012. Zeng, X., W.-K. Tao, S. Powell, R. A. Houze Jr., and P. Ciesielski, 2011: Comparing the water budgets between

  17. The IMACLIM model; Le modele IMACLIM

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This document provides annexes to the IMACLIM model which propose an actualized description of IMACLIM, model allowing the design of an evaluation tool of the greenhouse gases reduction policies. The model is described in a version coupled with the POLES, technical and economical model of the energy industry. Notations, equations, sources, processing and specifications are proposed and detailed. (A.L.B.)

  18. Building Mental Models by Dissecting Physical Models

    Science.gov (United States)

    Srivastava, Anveshna

    2016-01-01

    When students build physical models from prefabricated components to learn about model systems, there is an implicit trade-off between the physical degrees of freedom in building the model and the intensity of instructor supervision needed. Models that are too flexible, permitting multiple possible constructions require greater supervision to…

  19. Atmospheric Models/Global Atmospheric Modeling

    Science.gov (United States)

    1998-09-30

    Atmospheric Models /Global Atmospheric Modeling Timothy F. Hogan Naval Research Laboratory Monterey, CA 93943-5502 phone: (831) 656-4705 fax: (831...to 00-00-1998 4. TITLE AND SUBTITLE Atmospheric Models /Global Atmospheric Modeling 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...initialization of increments, improved cloud prediction, and improved surface fluxes) have been transition to 6.4 (Global Atmospheric Models , PE 0603207N, X-0513

  20. Models in architectural design

    OpenAIRE

    Pauwels, Pieter

    2017-01-01

    Whereas architects and construction specialists used to rely mainly on sketches and physical models as representations of their own cognitive design models, they rely now more and more on computer models. Parametric models, generative models, as-built models, building information models (BIM), and so forth, they are used daily by any practitioner in architectural design and construction. Although processes of abstraction and the actual architectural model-based reasoning itself of course rema...

  1. Rotating universe models

    International Nuclear Information System (INIS)

    Tozini, A.V.

    1984-01-01

    A review is made of some properties of the rotating Universe models. Godel's model is identified as a generalized filted model. Some properties of new solutions of the Einstein's equations, which are rotating non-stationary Universe models, are presented and analyzed. These models have the Godel's model as a particular case. Non-stationary cosmological models are found which are a generalization of the Godel's metrics in an analogous way in which Friedmann is to the Einstein's model. (L.C.) [pt

  2. Wake Expansion Models

    DEFF Research Database (Denmark)

    Branlard, Emmanuel Simon Pierre

    2017-01-01

    Different models of wake expansion are presented in this chapter: the 1D momentum theory model, the cylinder analog model and Theodorsen’s model. Far wake models such as the ones from Frandsen or Rathmann or only briefly mentioned. The different models are compared to each other. Results from...

  3. Model Manipulation for End-User Modelers

    DEFF Research Database (Denmark)

    Acretoaie, Vlad

    End-user modelers are domain experts who create and use models as part of their work. They are typically not Software Engineers, and have little or no programming and meta-modeling experience. However, using model manipulation languages developed in the context of Model-Driven Engineering often...... of these proposals. To achieve its first goal, the thesis presents the findings of a Systematic Mapping Study showing that human factors topics are scarcely and relatively poorly addressed in model transformation research. Motivated by these findings, the thesis explores the requirements of end-user modelers......, and transformations using their modeling notation and editor of choice. The VM* languages are implemented via a single execution engine, the VM* Runtime, built on top of the Henshin graph-based transformation engine. This approach combines the benefits of flexibility, maturity, and formality. To simplify model editor...

  4. Model-to-model interface for multiscale materials modeling

    Energy Technology Data Exchange (ETDEWEB)

    Antonelli, Perry Edward [Iowa State Univ., Ames, IA (United States)

    2017-12-17

    A low-level model-to-model interface is presented that will enable independent models to be linked into an integrated system of models. The interface is based on a standard set of functions that contain appropriate export and import schemas that enable models to be linked with no changes to the models themselves. These ideas are presented in the context of a specific multiscale material problem that couples atomistic-based molecular dynamics calculations to continuum calculations of fluid ow. These simulations will be used to examine the influence of interactions of the fluid with an adjacent solid on the fluid ow. The interface will also be examined by adding it to an already existing modeling code, Large-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) and comparing it with our own molecular dynamics code.

  5. Peuplement et organisation du territoire dans une région d'implantation ibâḍite : le Jebel Demmer dans le sud-est de l'Ifrîqiya (ve/xie- ixe/xve siècle

    Directory of Open Access Journals (Sweden)

    Mohamed Hassen

    2012-12-01

    Full Text Available Cet article s’intéresse aux formes de peuplement et d’organisation du territoire dans le Jebel Demmer à l’époque médiévale, lorsque cette région du sud de l’Ifrîqiya comportait encore une importante population ibadite, elle-même scindée en plusieurs groupes. Après avoir évoqué la délimitation du territoire à l’époque médiévale, l’article propose une réflexion sur l’apparition et la typologie des qsûr. Leur développement en tant qu’unités fondamentales dans l’organisation de l’espace local est rattaché aux invasions hilaliennes, qui provoquèrent un afflux important de populations ibâḍites dans cette région, qui devint pour quelque temps l’un des bastions de cette minorité en Ifrîqiyya. Enfin, la diffusion du malékisme est évoquée, faisant ressortir la lenteur de ce processus, encore inachevé au début du xve siècle.

  6. Collaborative Learning is an Effective Method for Improving the E-health Literacy of Older Adults in the Community. A Review of: Xie, B. (2011. Older adults, e-health literacy, and collaborative learning: An experimental study. Journal of the American Society for Information Science and Technology, 62(5, 933-946. doi: 10.1002/asi.21507

    Directory of Open Access Journals (Sweden)

    Theresa S. Arndt

    2011-01-01

    Full Text Available Objective – To determine whether collaborative learning strategies in an informal class setting can improve electronic health literacy skills of older adults.Design – Pre- and post-test instruments used to measure effects of an educational intervention.Setting – Small group classes offered at two branches of a large, publicly funded, urban public library in Maryland.Subjects – A total of 111 adults aged 52 to 91, mean age 70.4 (SD 8.0, completed the study. The majority of participants were from minority populations (66% African American, 3% Latino, 3% Asian. Thirty three percent of participants reported an annual household income below $20,000. Eight percent were non-native English speakers. The majority of participants had low-level or no computer/Internet experience prior to the study.Methods – Collaborative learning strategies were used in small group hands-on computer classes to deliver a standardized curriculum (Helping Older Adults Search for Health Information Online: A Toolkit for Trainers from the National Institute on Aging. Strategies employed were: explicit statement of group/participatory nature of class, periodic peer shared reflection times during class, active encouragement of discussion between peers, hands-on work with partners, group discussion of real-life questions from participants, and structured shared reflection time at the close of each session. Participants were recruited through local advertisements. No incentive other than the free classes was offered. Groups met for two hours, twice a week for four weeks. Assessment was via pre and post-tests. General computing knowledge/skills were measured using objective tests of abilities. Questions from several established scales were adapted for additional assessment. E-health literacy was measured using questions of perceived skill and comfort in finding health information online; perceived usefulness of the Internet for help making health decisions; and perceived importance of the Internet for obtaining health information. Subjects were also asked to report on changes to their health behaviour/decision- making post intervention, and learning effort expended during the study. Additional questions measured psychological adjustment to later life, attitudes toward computers, attitude toward the aging experience, and attitude toward the collaborative learning method and the class.Main Results – A dependent t-test analysis indicated strong significant gains post-test in computing/Internet knowledge and skills, and in e-health literacy efficacy (perceived skills/comfort with using the Internet for health information and decision-making. Pre-test results showed participants to be low on these measures, leaving much room for improvement. Perception of the usefulness and importance of the Internet for health decision-making also showed strong gains.Significant positive changes were also found in these areas of attitude: reduction of computer anxiety, attitude toward physical changes associated with aging, and improvement in attitude toward the collaborative learning method.A majority of participants indicated altering health-related behaviours as a result of the class, including changing the way they think about diet or exercise, changing the way they cope with a condition, and changing their approach to maintaining health.The results showed no significant change in self-esteem, self-efficacy, and psychological attitudes toward aging. Computer interest and efficacy also showed no significant change, perhaps because participants already measured high in these prior to the intervention.The amount of time participants spent preparing for class correlated significantly to e-health literacy efficacy and perceived importance of Internet health information, but not to other outcome measures.Group composition (gender, peer familiarity, prior computer experience did not affect outcomes; however composition was uneven, as groups were small and variable in size, and 71% of participants were female.Conclusion – The study supports the use of a collaborative learning approach to effectively deliver e-health literacy instruction to older adults in a community setting.

  7. La sémiologie des rêves dans la littérature en ancien français, xie-xiiie siècles. Stratégies des non-dits et discours d'insoumission

    Directory of Open Access Journals (Sweden)

    Claudine Korall

    2010-05-01

    Full Text Available date de soutenance : le 26 mai 2009composition du juryProfesseur Jacqueline Cerquiglini – Toulet (Université de Paris iv Sorbonne- rapporteur, Professeure Christiane Marchello – Nizia (École normale supérieure  -  Lsh- Rapporteur,Professeur Eve Sweetser (University of California  -  Berkeley,Professeur Michel de Fornel (École des hautes études en sciences sociales,Professeur Jean - Claude Schmitt (École des hautes études en sciences sociales - DirecteurRésuméNous étudions les formes d'ex...

  8. Concept Modeling vs. Data modeling in Practice

    DEFF Research Database (Denmark)

    Madsen, Bodil Nistrup; Erdman Thomsen, Hanne

    2015-01-01

    This chapter shows the usefulness of terminological concept modeling as a first step in data modeling. First, we introduce terminological concept modeling with terminological ontologies, i.e. concept systems enriched with characteristics modeled as feature specifications. This enables a formal...... account of the inheritance of characteristics and allows us to introduce a number of principles and constraints which render concept modeling more coherent than earlier approaches. Second, we explain how terminological ontologies can be used as the basis for developing conceptual and logical data models...

  9. Cognitive models embedded in system simulation models

    International Nuclear Information System (INIS)

    Siegel, A.I.; Wolf, J.J.

    1982-01-01

    If we are to discuss and consider cognitive models, we must first come to grips with two questions: (1) What is cognition; (2) What is a model. Presumably, the answers to these questions can provide a basis for defining a cognitive model. Accordingly, this paper first places these two questions into perspective. Then, cognitive models are set within the context of computer simulation models and a number of computer simulations of cognitive processes are described. Finally, pervasive issues are discussed vis-a-vis cognitive modeling in the computer simulation context

  10. Business Model Innovation

    OpenAIRE

    Dodgson, Mark; Gann, David; Phillips, Nelson; Massa, Lorenzo; Tucci, Christopher

    2014-01-01

    The chapter offers a broad review of the literature at the nexus between Business Models and innovation studies, and examines the notion of Business Model Innovation in three different situations: Business Model Design in newly formed organizations, Business Model Reconfiguration in incumbent firms, and Business Model Innovation in the broad context of sustainability. Tools and perspectives to make sense of Business Models and support managers and entrepreneurs in dealing with Business Model ...

  11. Air Quality Dispersion Modeling - Alternative Models

    Science.gov (United States)

    Models, not listed in Appendix W, that can be used in regulatory applications with case-by-case justification to the Reviewing Authority as noted in Section 3.2, Use of Alternative Models, in Appendix W.

  12. Wake modelling combining mesoscale and microscale models

    DEFF Research Database (Denmark)

    Badger, Jake; Volker, Patrick; Prospathospoulos, J.

    2013-01-01

    parameterizations are demonstrated in theWeather Research and Forecasting mesoscale model (WRF) in an idealized atmospheric flow. The model framework is the Horns Rev I wind farm experiencing an 7.97 m/s wind from 269.4o. Three of the four parameterizations use thrust output from the CRESflow-NS microscale model......In this paper the basis for introducing thrust information from microscale wake models into mesocale model wake parameterizations will be described. A classification system for the different types of mesoscale wake parameterizations is suggested and outlined. Four different mesoscale wake....... The characteristics of the mesoscale wake that developed from the four parameterizations are examined. In addition the mesoscale model wakes are compared to measurement data from Horns Rev I. Overall it is seen as an advantage to incorporate microscale model data in mesocale model wake parameterizations....

  13. A Model of Trusted Measurement Model

    OpenAIRE

    Ma Zhili; Wang Zhihao; Dai Liang; Zhu Xiaoqin

    2017-01-01

    A model of Trusted Measurement supporting behavior measurement based on trusted connection architecture (TCA) with three entities and three levels is proposed, and a frame to illustrate the model is given. The model synthesizes three trusted measurement dimensions including trusted identity, trusted status and trusted behavior, satisfies the essential requirements of trusted measurement, and unified the TCA with three entities and three levels.

  14. Molecular Models: Construction of Models with Magnets

    Directory of Open Access Journals (Sweden)

    Kalinovčić P.

    2015-07-01

    Full Text Available Molecular models are indispensable tools in teaching chemistry. Beside their high price, commercially available models are generally too small for classroom demonstration. This paper suggests how to make space-filling (callote models from Styrofoam with magnetic balls as connectors and disc magnets for showing molecular polarity

  15. Target Scattering Metrics: Model-Model and Model Data comparisons

    Science.gov (United States)

    2017-12-13

    be suitable for input to classification schemes. The investigated metrics are then applied to model-data comparisons. INTRODUCTION Metrics for...stainless steel replica of artillery shell Table 7. Targets used in the TIER simulations for the metrics study. C. Four Potential Metrics: Four...Four metrics were investigated. The metric, based on 2D cross-correlation, is typically used in classification algorithms. Model-model comparisons

  16. Modelling binary data

    CERN Document Server

    Collett, David

    2002-01-01

    INTRODUCTION Some Examples The Scope of this Book Use of Statistical Software STATISTICAL INFERENCE FOR BINARY DATA The Binomial Distribution Inference about the Success Probability Comparison of Two Proportions Comparison of Two or More Proportions MODELS FOR BINARY AND BINOMIAL DATA Statistical Modelling Linear Models Methods of Estimation Fitting Linear Models to Binomial Data Models for Binomial Response Data The Linear Logistic Model Fitting the Linear Logistic Model to Binomial Data Goodness of Fit of a Linear Logistic Model Comparing Linear Logistic Models Linear Trend in Proportions Comparing Stimulus-Response Relationships Non-Convergence and Overfitting Some other Goodness of Fit Statistics Strategy for Model Selection Predicting a Binary Response Probability BIOASSAY AND SOME OTHER APPLICATIONS The Tolerance Distribution Estimating an Effective Dose Relative Potency Natural Response Non-Linear Logistic Regression Models Applications of the Complementary Log-Log Model MODEL CHECKING Definition of Re...

  17. Modelling of Hydraulic Robot

    DEFF Research Database (Denmark)

    Madsen, Henrik; Zhou, Jianjun; Hansen, Lars Henrik

    1997-01-01

    This paper describes a case study of identifying the physical model (or the grey box model) of a hydraulic test robot. The obtained model is intended to provide a basis for model-based control of the robot. The physical model is formulated in continuous time and is derived by application...

  18. Automated data model evaluation

    International Nuclear Information System (INIS)

    Kazi, Zoltan; Kazi, Ljubica; Radulovic, Biljana

    2012-01-01

    Modeling process is essential phase within information systems development and implementation. This paper presents methods and techniques for analysis and evaluation of data model correctness. Recent methodologies and development results regarding automation of the process of model correctness analysis and relations with ontology tools has been presented. Key words: Database modeling, Data model correctness, Evaluation

  19. Elastic Appearance Models

    DEFF Research Database (Denmark)

    Hansen, Mads Fogtmann; Fagertun, Jens; Larsen, Rasmus

    2011-01-01

    This paper presents a fusion of the active appearance model (AAM) and the Riemannian elasticity framework which yields a non-linear shape model and a linear texture model – the active elastic appearance model (EAM). The non-linear elasticity shape model is more flexible than the usual linear subs...

  20. Forest-fire models

    Science.gov (United States)

    Haiganoush Preisler; Alan Ager

    2013-01-01

    For applied mathematicians forest fire models refer mainly to a non-linear dynamic system often used to simulate spread of fire. For forest managers forest fire models may pertain to any of the three phases of fire management: prefire planning (fire risk models), fire suppression (fire behavior models), and postfire evaluation (fire effects and economic models). In...

  1. "Bohr's Atomic Model."

    Science.gov (United States)

    Willden, Jeff

    2001-01-01

    "Bohr's Atomic Model" is a small interactive multimedia program that introduces the viewer to a simplified model of the atom. This interactive simulation lets students build an atom using an atomic construction set. The underlying design methodology for "Bohr's Atomic Model" is model-centered instruction, which means the central model of the…

  2. From Numeric Models to Granular System Modeling

    Directory of Open Access Journals (Sweden)

    Witold Pedrycz

    2015-03-01

    To make this study self-contained, we briefly recall the key concepts of granular computing and demonstrate how this conceptual framework and its algorithmic fundamentals give rise to granular models. We discuss several representative formal setups used in describing and processing information granules including fuzzy sets, rough sets, and interval calculus. Key architectures of models dwell upon relationships among information granules. We demonstrate how information granularity and its optimization can be regarded as an important design asset to be exploited in system modeling and giving rise to granular models. With this regard, an important category of rule-based models along with their granular enrichments is studied in detail.

  3. Geologic Framework Model Analysis Model Report

    International Nuclear Information System (INIS)

    Clayton, R.

    2000-01-01

    The purpose of this report is to document the Geologic Framework Model (GFM), Version 3.1 (GFM3.1) with regard to data input, modeling methods, assumptions, uncertainties, limitations, and validation of the model results, qualification status of the model, and the differences between Version 3.1 and previous versions. The GFM represents a three-dimensional interpretation of the stratigraphy and structural features of the location of the potential Yucca Mountain radioactive waste repository. The GFM encompasses an area of 65 square miles (170 square kilometers) and a volume of 185 cubic miles (771 cubic kilometers). The boundaries of the GFM were chosen to encompass the most widely distributed set of exploratory boreholes (the Water Table or WT series) and to provide a geologic framework over the area of interest for hydrologic flow and radionuclide transport modeling through the unsaturated zone (UZ). The depth of the model is constrained by the inferred depth of the Tertiary-Paleozoic unconformity. The GFM was constructed from geologic map and borehole data. Additional information from measured stratigraphy sections, gravity profiles, and seismic profiles was also considered. This interim change notice (ICN) was prepared in accordance with the Technical Work Plan for the Integrated Site Model Process Model Report Revision 01 (CRWMS M and O 2000). The constraints, caveats, and limitations associated with this model are discussed in the appropriate text sections that follow. The GFM is one component of the Integrated Site Model (ISM) (Figure l), which has been developed to provide a consistent volumetric portrayal of the rock layers, rock properties, and mineralogy of the Yucca Mountain site. The ISM consists of three components: (1) Geologic Framework Model (GFM); (2) Rock Properties Model (RPM); and (3) Mineralogic Model (MM). The ISM merges the detailed project stratigraphy into model stratigraphic units that are most useful for the primary downstream models and

  4. Geologic Framework Model Analysis Model Report

    Energy Technology Data Exchange (ETDEWEB)

    R. Clayton

    2000-12-19

    The purpose of this report is to document the Geologic Framework Model (GFM), Version 3.1 (GFM3.1) with regard to data input, modeling methods, assumptions, uncertainties, limitations, and validation of the model results, qualification status of the model, and the differences between Version 3.1 and previous versions. The GFM represents a three-dimensional interpretation of the stratigraphy and structural features of the location of the potential Yucca Mountain radioactive waste repository. The GFM encompasses an area of 65 square miles (170 square kilometers) and a volume of 185 cubic miles (771 cubic kilometers). The boundaries of the GFM were chosen to encompass the most widely distributed set of exploratory boreholes (the Water Table or WT series) and to provide a geologic framework over the area of interest for hydrologic flow and radionuclide transport modeling through the unsaturated zone (UZ). The depth of the model is constrained by the inferred depth of the Tertiary-Paleozoic unconformity. The GFM was constructed from geologic map and borehole data. Additional information from measured stratigraphy sections, gravity profiles, and seismic profiles was also considered. This interim change notice (ICN) was prepared in accordance with the Technical Work Plan for the Integrated Site Model Process Model Report Revision 01 (CRWMS M&O 2000). The constraints, caveats, and limitations associated with this model are discussed in the appropriate text sections that follow. The GFM is one component of the Integrated Site Model (ISM) (Figure l), which has been developed to provide a consistent volumetric portrayal of the rock layers, rock properties, and mineralogy of the Yucca Mountain site. The ISM consists of three components: (1) Geologic Framework Model (GFM); (2) Rock Properties Model (RPM); and (3) Mineralogic Model (MM). The ISM merges the detailed project stratigraphy into model stratigraphic units that are most useful for the primary downstream models and the

  5. Mathematical Modeling Using MATLAB

    National Research Council Canada - National Science Library

    Phillips, Donovan

    1998-01-01

    .... Mathematical Modeling Using MA MATLAB acts as a companion resource to A First Course in Mathematical Modeling with the goal of guiding the reader to a fuller understanding of the modeling process...

  6. Energy modelling software

    CSIR Research Space (South Africa)

    Osburn, L

    2010-01-01

    Full Text Available The construction industry has turned to energy modelling in order to assist them in reducing the amount of energy consumed by buildings. However, while the energy loads of buildings can be accurately modelled, energy models often under...

  7. Multivariate GARCH models

    DEFF Research Database (Denmark)

    Silvennoinen, Annastiina; Teräsvirta, Timo

    This article contains a review of multivariate GARCH models. Most common GARCH models are presented and their properties considered. This also includes nonparametric and semiparametric models. Existing specification and misspecification tests are discussed. Finally, there is an empirical example...

  8. N-Gram models

    NARCIS (Netherlands)

    Hiemstra, Djoerd; Liu, Ling; Tamer Özsu, M.

    2017-01-01

    In language modeling, n-gram models are probabilistic models of text that use some limited amount of history, or word dependencies, where n refers to the number of words that participate in the dependence relation.

  9. Business Model Canvas

    OpenAIRE

    Souza, D', Austin

    2013-01-01

    Presentatie gegeven op 13 mei 2013 op de bijeenkomst "Business Model Canvas Challenge Assen". Het Business Model Canvas is ontworpen door Alex Osterwalder. Het model werkt zeer overzichtelijk en bestaat uit negen bouwstenen.

  10. Wildfire Risk Main Model

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — The model combines three modeled fire behavior parameters (rate of spread, flame length, crown fire potential) and one modeled ecological health measure (fire regime...

  11. Lapse Rate Modeling

    DEFF Research Database (Denmark)

    De Giovanni, Domenico

    prepayment models for mortgage backed securities, this paper builds a Rational Expectation (RE) model describing the policyholders' behavior in lapsing the contract. A market model with stochastic interest rates is considered, and the pricing is carried out through numerical approximation...

  12. Lapse rate modeling

    DEFF Research Database (Denmark)

    De Giovanni, Domenico

    2010-01-01

    prepayment models for mortgage backed securities, this paper builds a Rational Expectation (RE) model describing the policyholders' behavior in lapsing the contract. A market model with stochastic interest rates is considered, and the pricing is carried out through numerical approximation...

  13. Comparative genomics of DNA recombination and repair in cyanobacteria: biotechnological implications

    Directory of Open Access Journals (Sweden)

    Corinne Cassier-Chauvat

    2016-11-01

    Full Text Available Cyanobacteria are fascinating photosynthetic prokaryotes that are regarded as the ancestors of the plant chloroplast; the purveyors of oxygen and biomass for the food chain; and promising cell factories for an environmentally friendly production of chemicals. In colonizing most waters and soils of our planet, cyanobacteria are inevitably challenged by environmental stresses that generate DNA damages. Furthermore, many strains engineered for biotechnological purposes can use DNA recombination to stop synthesizing the biotechnological product. Hence, it is important to study DNA recombination and repair in cyanobacteria for both basic and applied research. This review reports what is known in a few widely studied model cyanobacteria and what can be inferred by mining the sequenced genomes of morphologically and physiologically diverse strains. We show that cyanobacteria possess many E. coli-like DNA recombination and repair genes, and possibly other genes not yet identified. E. coli-homolog genes are unevenly distributed in cyanobacteria, in agreement with their wide genome diversity. Many genes are extremely well conserved in cyanobacteria (mutMS, radA, recA, recFO, recG, recN, ruvABC, ssb and uvrABCD, even in small genomes, suggesting that they encode the core DNA repair process. In addition to these core genes, the marine Prochlorococcus and Synechococcus strains harbor recBCD (DNA recombination, umuCD (mutational DNA replication, as well as the key SOS genes lexA (regulation of the SOS system and sulA (postponing of cell division until completion of DNA reparation. Hence, these strains could possess an E. coli-type SOS system. In contrast, several cyanobacteria endowed with larger genomes lack typical SOS genes. For examples, the two studied Gloeobacter strains lack alkB, lexA and sulA; and Synechococcus PCC7942 has neither lexA nor recCD. Furthermore, the Synechocystis PCC6803 lexA product does not regulate DNA repair genes. Collectively

  14. Comparative Genomics of DNA Recombination and Repair in Cyanobacteria: Biotechnological Implications

    Science.gov (United States)

    Cassier-Chauvat, Corinne; Veaudor, Théo; Chauvat, Franck

    2016-01-01

    Cyanobacteria are fascinating photosynthetic prokaryotes that are regarded as the ancestors of the plant chloroplast; the purveyors of oxygen and biomass for the food chain; and promising cell factories for an environmentally friendly production of chemicals. In colonizing most waters and soils of our planet, cyanobacteria are inevitably challenged by environmental stresses that generate DNA damages. Furthermore, many strains engineered for biotechnological purposes can use DNA recombination to stop synthesizing the biotechnological product. Hence, it is important to study DNA recombination and repair in cyanobacteria for both basic and applied research. This review reports what is known in a few widely studied model cyanobacteria and what can be inferred by mining the sequenced genomes of morphologically and physiologically diverse strains. We show that cyanobacteria possess many E. coli-like DNA recombination and repair genes, and possibly other genes not yet identified. E. coli-homolog genes are unevenly distributed in cyanobacteria, in agreement with their wide genome diversity. Many genes are extremely well conserved in cyanobacteria (mutMS, radA, recA, recFO, recG, recN, ruvABC, ssb, and uvrABCD), even in small genomes, suggesting that they encode the core DNA repair process. In addition to these core genes, the marine Prochlorococcus and Synechococcus strains harbor recBCD (DNA recombination), umuCD (mutational DNA replication), as well as the key SOS genes lexA (regulation of the SOS system) and sulA (postponing of cell division until completion of DNA reparation). Hence, these strains could possess an E. coli-type SOS system. In contrast, several cyanobacteria endowed with larger genomes lack typical SOS genes. For examples, the two studied Gloeobacter strains lack alkB, lexA, and sulA; and Synechococcus PCC7942 has neither lexA nor recCD. Furthermore, the Synechocystis PCC6803 lexA product does not regulate DNA repair genes. Collectively, these findings

  15. Quintessence Model Building

    OpenAIRE

    Brax, P.; Martin, J.; Riazuelo, A.

    2001-01-01

    A short review of some of the aspects of quintessence model building is presented. We emphasize the role of tracking models and their possible supersymmetric origin. A short review of some of the aspects of quintessence model building is presented. We emphasize the role of tracking models and their possible supersymmetric origin. A short review of some of the aspects of quintessence model building is presented. We emphasize the role of tracking models and their possible supersymmetric o...

  16. Computational neurogenetic modeling

    CERN Document Server

    Benuskova, Lubica

    2010-01-01

    Computational Neurogenetic Modeling is a student text, introducing the scope and problems of a new scientific discipline - Computational Neurogenetic Modeling (CNGM). CNGM is concerned with the study and development of dynamic neuronal models for modeling brain functions with respect to genes and dynamic interactions between genes. These include neural network models and their integration with gene network models. This new area brings together knowledge from various scientific disciplines, such as computer and information science, neuroscience and cognitive science, genetics and molecular biol

  17. GaN on Diamond with Ultra-Low Thermal Barrier Resistance

    Science.gov (United States)

    2016-03-31

    GaN-on-Diamond with Ultra -Low Thermal Barrier Resistance Xing Gu1, Cathy Lee1, Jinqiao Xie1, Edward Beam1, Michael Becker2, Timothy A. Grotjohn2...previously reported best data, and close to the limit predicted by theoretical models for GaN-diamond interfaces Keywords: GaN-on-Diamond; ultra -low...is yet to be realized, mainly due to thermal limitations. Diamond, which offers superior thermal conductivity of ~ 2000 W/ mK , is a natural choice

  18. Overuse Injury Assessment Model

    National Research Council Canada - National Science Library

    Stuhmiller, James H; Shen, Weixin; Sih, Bryant

    2005-01-01

    .... Previously, we developed a preliminary model that predicted the stress fracture rate and used biomechanical modeling, nonlinear optimization for muscle force, and bone structural analysis to estimate...

  19. Multilevel modeling using R

    CERN Document Server

    Finch, W Holmes; Kelley, Ken

    2014-01-01

    A powerful tool for analyzing nested designs in a variety of fields, multilevel/hierarchical modeling allows researchers to account for data collected at multiple levels. Multilevel Modeling Using R provides you with a helpful guide to conducting multilevel data modeling using the R software environment.After reviewing standard linear models, the authors present the basics of multilevel models and explain how to fit these models using R. They then show how to employ multilevel modeling with longitudinal data and demonstrate the valuable graphical options in R. The book also describes models fo

  20. Cosmological models without singularities

    International Nuclear Information System (INIS)

    Petry, W.

    1981-01-01

    A previously studied theory of gravitation in flat space-time is applied to homogeneous and isotropic cosmological models. There exist two different classes of models without singularities: (i) ever-expanding models, (ii) oscillating models. The first class contains models with hot big bang. For these models there exist at the beginning of the universe-in contrast to Einstein's theory-very high but finite densities of matter and radiation with a big bang of very short duration. After short time these models pass into the homogeneous and isotropic models of Einstein's theory with spatial curvature equal to zero and cosmological constant ALPHA >= O. (author)

  1. Validated dynamic flow model

    DEFF Research Database (Denmark)

    Knudsen, Torben

    2011-01-01

    model structure suggested by University of Lund the WP4 leader. This particular model structure has the advantages that it fits better into the control design frame work used by WP3-4 compared to the model structures previously developed in WP2. The different model structures are first summarised....... Then issues dealing with optimal experimental design is considered. Finally the parameters are estimated in the chosen static and dynamic models and a validation is performed. Two of the static models, one of them the additive model, explains the data well. In case of dynamic models the suggested additive...

  2. Environmental Modeling Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Environmental Modeling Center provides the computational tools to perform geostatistical analysis, to model ground water and atmospheric releases for comparison...

  3. TRACKING CLIMATE MODELS

    Data.gov (United States)

    National Aeronautics and Space Administration — CLAIRE MONTELEONI*, GAVIN SCHMIDT, AND SHAILESH SAROHA* Climate models are complex mathematical models designed by meteorologists, geophysicists, and climate...

  4. Regularized Structural Equation Modeling

    Science.gov (United States)

    Jacobucci, Ross; Grimm, Kevin J.; McArdle, John J.

    2016-01-01

    A new method is proposed that extends the use of regularization in both lasso and ridge regression to structural equation models. The method is termed regularized structural equation modeling (RegSEM). RegSEM penalizes specific parameters in structural equation models, with the goal of creating easier to understand and simpler models. Although regularization has gained wide adoption in regression, very little has transferred to models with latent variables. By adding penalties to specific parameters in a structural equation model, researchers have a high level of flexibility in reducing model complexity, overcoming poor fitting models, and the creation of models that are more likely to generalize to new samples. The proposed method was evaluated through a simulation study, two illustrative examples involving a measurement model, and one empirical example involving the structural part of the model to demonstrate RegSEM’s utility. PMID:27398019

  5. Integrated Site Model Process Model Report

    International Nuclear Information System (INIS)

    Booth, T.

    2000-01-01

    The Integrated Site Model (ISM) provides a framework for discussing the geologic features and properties of Yucca Mountain, which is being evaluated as a potential site for a geologic repository for the disposal of nuclear waste. The ISM is important to the evaluation of the site because it provides 3-D portrayals of site geologic, rock property, and mineralogic characteristics and their spatial variabilities. The ISM is not a single discrete model; rather, it is a set of static representations that provide three-dimensional (3-D), computer representations of site geology, selected hydrologic and rock properties, and mineralogic-characteristics data. These representations are manifested in three separate model components of the ISM: the Geologic Framework Model (GFM), the Rock Properties Model (RPM), and the Mineralogic Model (MM). The GFM provides a representation of the 3-D stratigraphy and geologic structure. Based on the framework provided by the GFM, the RPM and MM provide spatial simulations of the rock and hydrologic properties, and mineralogy, respectively. Functional summaries of the component models and their respective output are provided in Section 1.4. Each of the component models of the ISM considers different specific aspects of the site geologic setting. Each model was developed using unique methodologies and inputs, and the determination of the modeled units for each of the components is dependent on the requirements of that component. Therefore, while the ISM represents the integration of the rock properties and mineralogy into a geologic framework, the discussion of ISM construction and results is most appropriately presented in terms of the three separate components. This Process Model Report (PMR) summarizes the individual component models of the ISM (the GFM, RPM, and MM) and describes how the three components are constructed and combined to form the ISM

  6. Better models are more effectively connected models

    Science.gov (United States)

    Nunes, João Pedro; Bielders, Charles; Darboux, Frederic; Fiener, Peter; Finger, David; Turnbull-Lloyd, Laura; Wainwright, John

    2016-04-01

    The concept of hydrologic and geomorphologic connectivity describes the processes and pathways which link sources (e.g. rainfall, snow and ice melt, springs, eroded areas and barren lands) to accumulation areas (e.g. foot slopes, streams, aquifers, reservoirs), and the spatial variations thereof. There are many examples of hydrological and sediment connectivity on a watershed scale; in consequence, a process-based understanding of connectivity is crucial to help managers understand their systems and adopt adequate measures for flood prevention, pollution mitigation and soil protection, among others. Modelling is often used as a tool to understand and predict fluxes within a catchment by complementing observations with model results. Catchment models should therefore be able to reproduce the linkages, and thus the connectivity of water and sediment fluxes within the systems under simulation. In modelling, a high level of spatial and temporal detail is desirable to ensure taking into account a maximum number of components, which then enables connectivity to emerge from the simulated structures and functions. However, computational constraints and, in many cases, lack of data prevent the representation of all relevant processes and spatial/temporal variability in most models. In most cases, therefore, the level of detail selected for modelling is too coarse to represent the system in a way in which connectivity can emerge; a problem which can be circumvented by representing fine-scale structures and processes within coarser scale models using a variety of approaches. This poster focuses on the results of ongoing discussions on modelling connectivity held during several workshops within COST Action Connecteur. It assesses the current state of the art of incorporating the concept of connectivity in hydrological and sediment models, as well as the attitudes of modellers towards this issue. The discussion will focus on the different approaches through which connectivity

  7. Modelling bankruptcy prediction models in Slovak companies

    Directory of Open Access Journals (Sweden)

    Kovacova Maria

    2017-01-01

    Full Text Available An intensive research from academics and practitioners has been provided regarding models for bankruptcy prediction and credit risk management. In spite of numerous researches focusing on forecasting bankruptcy using traditional statistics techniques (e.g. discriminant analysis and logistic regression and early artificial intelligence models (e.g. artificial neural networks, there is a trend for transition to machine learning models (support vector machines, bagging, boosting, and random forest to predict bankruptcy one year prior to the event. Comparing the performance of this with unconventional approach with results obtained by discriminant analysis, logistic regression, and neural networks application, it has been found that bagging, boosting, and random forest models outperform the others techniques, and that all prediction accuracy in the testing sample improves when the additional variables are included. On the other side the prediction accuracy of old and well known bankruptcy prediction models is quiet high. Therefore, we aim to analyse these in some way old models on the dataset of Slovak companies to validate their prediction ability in specific conditions. Furthermore, these models will be modelled according to new trends by calculating the influence of elimination of selected variables on the overall prediction ability of these models.

  8. Generalized latent variable modeling multilevel, longitudinal, and structural equation models

    CERN Document Server

    Skrondal, Anders; Rabe-Hesketh, Sophia

    2004-01-01

    This book unifies and extends latent variable models, including multilevel or generalized linear mixed models, longitudinal or panel models, item response or factor models, latent class or finite mixture models, and structural equation models.

  9. Biosphere Model Report

    International Nuclear Information System (INIS)

    M. A. Wasiolek

    2003-01-01

    The purpose of this report is to document the biosphere model, the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), which describes radionuclide transport processes in the biosphere and associated human exposure that may arise as the result of radionuclide release from the geologic repository at Yucca Mountain. The biosphere model is one of the process models that support the Yucca Mountain Project (YMP) Total System Performance Assessment (TSPA) for the license application (LA), the TSPA-LA. The ERMYN model provides the capability of performing human radiation dose assessments. This report documents the biosphere model, which includes: (1) Describing the reference biosphere, human receptor, exposure scenarios, and primary radionuclides for each exposure scenario (Section 6.1); (2) Developing a biosphere conceptual model using site-specific features, events, and processes (FEPs), the reference biosphere, the human receptor, and assumptions (Section 6.2 and Section 6.3); (3) Building a mathematical model using the biosphere conceptual model and published biosphere models (Sections 6.4 and 6.5); (4) Summarizing input parameters for the mathematical model, including the uncertainty associated with input values (Section 6.6); (5) Identifying improvements in the ERMYN model compared with the model used in previous biosphere modeling (Section 6.7); (6) Constructing an ERMYN implementation tool (model) based on the biosphere mathematical model using GoldSim stochastic simulation software (Sections 6.8 and 6.9); (7) Verifying the ERMYN model by comparing output from the software with hand calculations to ensure that the GoldSim implementation is correct (Section 6.10); and (8) Validating the ERMYN model by corroborating it with published biosphere models; comparing conceptual models, mathematical models, and numerical results (Section 7)

  10. Biosphere Model Report

    Energy Technology Data Exchange (ETDEWEB)

    D. W. Wu

    2003-07-16

    The purpose of this report is to document the biosphere model, the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), which describes radionuclide transport processes in the biosphere and associated human exposure that may arise as the result of radionuclide release from the geologic repository at Yucca Mountain. The biosphere model is one of the process models that support the Yucca Mountain Project (YMP) Total System Performance Assessment (TSPA) for the license application (LA), the TSPA-LA. The ERMYN model provides the capability of performing human radiation dose assessments. This report documents the biosphere model, which includes: (1) Describing the reference biosphere, human receptor, exposure scenarios, and primary radionuclides for each exposure scenario (Section 6.1); (2) Developing a biosphere conceptual model using site-specific features, events, and processes (FEPs), the reference biosphere, the human receptor, and assumptions (Section 6.2 and Section 6.3); (3) Building a mathematical model using the biosphere conceptual model and published biosphere models (Sections 6.4 and 6.5); (4) Summarizing input parameters for the mathematical model, including the uncertainty associated with input values (Section 6.6); (5) Identifying improvements in the ERMYN model compared with the model used in previous biosphere modeling (Section 6.7); (6) Constructing an ERMYN implementation tool (model) based on the biosphere mathematical model using GoldSim stochastic simulation software (Sections 6.8 and 6.9); (7) Verifying the ERMYN model by comparing output from the software with hand calculations to ensure that the GoldSim implementation is correct (Section 6.10); and (8) Validating the ERMYN model by corroborating it with published biosphere models; comparing conceptual models, mathematical models, and numerical results (Section 7).

  11. Biosphere Model Report

    Energy Technology Data Exchange (ETDEWEB)

    M. A. Wasiolek

    2003-10-27

    The purpose of this report is to document the biosphere model, the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), which describes radionuclide transport processes in the biosphere and associated human exposure that may arise as the result of radionuclide release from the geologic repository at Yucca Mountain. The biosphere model is one of the process models that support the Yucca Mountain Project (YMP) Total System Performance Assessment (TSPA) for the license application (LA), the TSPA-LA. The ERMYN model provides the capability of performing human radiation dose assessments. This report documents the biosphere model, which includes: (1) Describing the reference biosphere, human receptor, exposure scenarios, and primary radionuclides for each exposure scenario (Section 6.1); (2) Developing a biosphere conceptual model using site-specific features, events, and processes (FEPs), the reference biosphere, the human receptor, and assumptions (Section 6.2 and Section 6.3); (3) Building a mathematical model using the biosphere conceptual model and published biosphere models (Sections 6.4 and 6.5); (4) Summarizing input parameters for the mathematical model, including the uncertainty associated with input values (Section 6.6); (5) Identifying improvements in the ERMYN model compared with the model used in previous biosphere modeling (Section 6.7); (6) Constructing an ERMYN implementation tool (model) based on the biosphere mathematical model using GoldSim stochastic simulation software (Sections 6.8 and 6.9); (7) Verifying the ERMYN model by comparing output from the software with hand calculations to ensure that the GoldSim implementation is correct (Section 6.10); and (8) Validating the ERMYN model by corroborating it with published biosphere models; comparing conceptual models, mathematical models, and numerical results (Section 7).

  12. Lumped Thermal Household Model

    DEFF Research Database (Denmark)

    Biegel, Benjamin; Andersen, Palle; Stoustrup, Jakob

    2013-01-01

    a lumped model approach as an alternative to the individual models. In the lumped model, the portfolio is seen as baseline consumption superimposed with an ideal storage of limited power and energy capacity. The benefit of such a lumped model is that the computational effort of flexibility optimization...

  13. The Moody Mask Model

    DEFF Research Database (Denmark)

    Larsen, Bjarke Alexander; Andkjær, Kasper Ingdahl; Schoenau-Fog, Henrik

    2015-01-01

    This paper proposes a new relation model, called "The Moody Mask model", for Interactive Digital Storytelling (IDS), based on Franceso Osborne's "Mask Model" from 2011. This, mixed with some elements from Chris Crawford's Personality Models, is a system designed for dynamic interaction between ch...

  14. The Model Confidence Set

    DEFF Research Database (Denmark)

    Hansen, Peter Reinhard; Lunde, Asger; Nason, James M.

    The paper introduces the model confidence set (MCS) and applies it to the selection of models. A MCS is a set of models that is constructed such that it will contain the best model with a given level of confidence. The MCS is in this sense analogous to a confidence interval for a parameter. The MCS...

  15. AIDS Epidemiological models

    Science.gov (United States)

    Rahmani, Fouad Lazhar

    2010-11-01

    The aim of this paper is to present mathematical modelling of the spread of infection in the context of the transmission of the human immunodeficiency virus (HIV) and the acquired immune deficiency syndrome (AIDS). These models are based in part on the models suggested in the field of th AIDS mathematical modelling as reported by ISHAM [6].

  16. Numerical Modelling of Streams

    DEFF Research Database (Denmark)

    Vestergaard, Kristian

    In recent years there has been a sharp increase in the use of numerical water quality models. Numeric water quality modeling can be divided into three steps: Hydrodynamic modeling for the determination of stream flow and water levels. Modelling of transport and dispersion of a conservative...

  17. A Model for Conversation

    DEFF Research Database (Denmark)

    Ayres, Phil

    2012-01-01

    This essay discusses models. It examines what models are, the roles models perform and suggests various intentions that underlie their construction and use. It discusses how models act as a conversational partner, and how they support various forms of conversation within the conversational activity...

  18. Generic Market Models

    NARCIS (Netherlands)

    R. Pietersz (Raoul); M. van Regenmortel

    2005-01-01

    textabstractCurrently, there are two market models for valuation and risk management of interest rate derivatives, the LIBOR and swap market models. In this paper, we introduce arbitrage-free constant maturity swap (CMS) market models and generic market models featuring forward rates that span

  19. Modeling the Accidental Deaths

    Directory of Open Access Journals (Sweden)

    Mariyam Hafeez

    2008-01-01

    Full Text Available The model for accidental deaths in the city of Lahore has been developed by using a class of Generalized Linear Models. Various link functions have been used in developing the model. The diagnostic checks have been carried out to see the validity of the fitted model.

  20. Cultural Resource Predictive Modeling

    Science.gov (United States)

    2017-10-01

    refining formal, inductive predictive models is the quality of the archaeological and environmental data. To build models efficiently, relevant...geomorphology, and historic information . Lessons Learned: The original model was focused on the identification of prehistoric resources. This...system but uses predictive modeling informally . For example, there is no probability for buried archaeological deposits on the Burton Mesa, but there is

  1. Modelling Railway Interlocking Systems

    DEFF Research Database (Denmark)

    Lindegaard, Morten Peter; Viuf, P.; Haxthausen, Anne Elisabeth

    2000-01-01

    In this report we present a model of interlocking systems, and describe how the model may be validated by simulation. Station topologies are modelled by graphs in which the nodes denote track segments, and the edges denote connectivity for train traÆc. Points and signals are modelled by annotatio...

  2. Lumped-parameter models

    Energy Technology Data Exchange (ETDEWEB)

    Ibsen, Lars Bo; Liingaard, M.

    2006-12-15

    A lumped-parameter model represents the frequency dependent soil-structure interaction of a massless foundation placed on or embedded into an unbounded soil domain. In this technical report the steps of establishing a lumped-parameter model are presented. Following sections are included in this report: Static and dynamic formulation, Simple lumped-parameter models and Advanced lumped-parameter models. (au)

  3. Comparing Active Vision Models

    NARCIS (Netherlands)

    Croon, G.C.H.E. de; Sprinkhuizen-Kuyper, I.G.; Postma, E.O.

    2009-01-01

    Active vision models can simplify visual tasks, provided that they can select sensible actions given incoming sensory inputs. Many active vision models have been proposed, but a comparative evaluation of these models is lacking. We present a comparison of active vision models from two different

  4. Comparing active vision models

    NARCIS (Netherlands)

    Croon, G.C.H.E. de; Sprinkhuizen-Kuyper, I.G.; Postma, E.O.

    2009-01-01

    Active vision models can simplify visual tasks, provided that they can select sensible actions given incoming sensory inputs. Many active vision models have been proposed, but a comparative evaluation of these models is lacking. We present a comparison of active vision models from two different

  5. White Paper on Modelling

    NARCIS (Netherlands)

    Van Bloemendaal, Karen; Dijkema, Gerard P.J.; Woerdman, Edwin; Jong, Mattheus

    2015-01-01

    This White Paper provides an overview of the modelling approaches adopted by the project partners in the EDGaR project 'Understanding Gas Sector Intra- and Inter- Market interactions' (UGSIIMI). The paper addresses three types of models: complementarity modelling, agent-based modelling and property

  6. A Model for Conversation

    DEFF Research Database (Denmark)

    Ayres, Phil

    2012-01-01

    This essay discusses models. It examines what models are, the roles models perform and suggests various intentions that underlie their construction and use. It discusses how models act as a conversational partner, and how they support various forms of conversation within the conversational activity...... of design. Three distinctions are drawn through which to develop this discussion of models in an architectural context. An examination of these distinctions serves to nuance particular characteristics and roles of models, the modelling activity itself and those engaged in it....

  7. Wastewater treatment models

    DEFF Research Database (Denmark)

    Gernaey, Krist; Sin, Gürkan

    2011-01-01

    The state-of-the-art level reached in modeling wastewater treatment plants (WWTPs) is reported. For suspended growth systems, WWTP models have evolved from simple description of biological removal of organic carbon and nitrogen in aeration tanks (ASM1 in 1987) to more advanced levels including...... of WWTP modeling by linking the wastewater treatment line with the sludge handling line in one modeling platform. Application of WWTP models is currently rather time consuming and thus expensive due to the high model complexity, and requires a great deal of process knowledge and modeling expertise...

  8. Wastewater Treatment Models

    DEFF Research Database (Denmark)

    Gernaey, Krist; Sin, Gürkan

    2008-01-01

    The state-of-the-art level reached in modeling wastewater treatment plants (WWTPs) is reported. For suspended growth systems, WWTP models have evolved from simple description of biological removal of organic carbon and nitrogen in aeration tanks (ASM1 in 1987) to more advanced levels including...... the practice of WWTP modeling by linking the wastewater treatment line with the sludge handling line in one modeling platform. Application of WWTP models is currently rather time consuming and thus expensive due to the high model complexity, and requires a great deal of process knowledge and modeling expertise...

  9. Applied stochastic modelling

    CERN Document Server

    Morgan, Byron JT; Tanner, Martin Abba; Carlin, Bradley P

    2008-01-01

    Introduction and Examples Introduction Examples of data sets Basic Model Fitting Introduction Maximum-likelihood estimation for a geometric model Maximum-likelihood for the beta-geometric model Modelling polyspermy Which model? What is a model for? Mechanistic models Function Optimisation Introduction MATLAB: graphs and finite differences Deterministic search methods Stochastic search methods Accuracy and a hybrid approach Basic Likelihood ToolsIntroduction Estimating standard errors and correlations Looking at surfaces: profile log-likelihoods Confidence regions from profiles Hypothesis testing in model selectionScore and Wald tests Classical goodness of fit Model selection biasGeneral Principles Introduction Parameterisation Parameter redundancy Boundary estimates Regression and influence The EM algorithm Alternative methods of model fitting Non-regular problemsSimulation Techniques Introduction Simulating random variables Integral estimation Verification Monte Carlo inference Estimating sampling distributi...

  10. The Hospitable Meal Model

    DEFF Research Database (Denmark)

    Justesen, Lise; Overgaard, Svend Skafte

    2017-01-01

    -ended approach towards meal experiences. The underlying purpose of The Hospitable Meal Model is to provide the basis for creating value for the individuals involved in institutional meal services. The Hospitable Meal Model was developed on the basis of an empirical study on hospital meal experiences explored......This article presents an analytical model that aims to conceptualize how meal experiences are framed when taking into account a dynamic understanding of hospitality: the meal model is named The Hospitable Meal Model. The idea behind The Hospitable Meal Model is to present a conceptual model...... that can serve as a frame for developing hospitable meal competencies among professionals working within the area of institutional foodservices as well as a conceptual model for analysing meal experiences. The Hospitable Meal Model transcends and transforms existing meal models by presenting a more open...

  11. Calibrated Properties Model

    Energy Technology Data Exchange (ETDEWEB)

    C. Ahlers; H. Liu

    2000-03-12

    The purpose of this Analysis/Model Report (AMR) is to document the Calibrated Properties Model that provides calibrated parameter sets for unsaturated zone (UZ) flow and transport process models for the Yucca Mountain Site Characterization Project (YMP). This work was performed in accordance with the ''AMR Development Plan for U0035 Calibrated Properties Model REV00. These calibrated property sets include matrix and fracture parameters for the UZ Flow and Transport Model (UZ Model), drift seepage models, drift-scale and mountain-scale coupled-processes models, and Total System Performance Assessment (TSPA) models as well as Performance Assessment (PA) and other participating national laboratories and government agencies. These process models provide the necessary framework to test conceptual hypotheses of flow and transport at different scales and predict flow and transport behavior under a variety of climatic and thermal-loading conditions.

  12. Calibrated Properties Model

    Energy Technology Data Exchange (ETDEWEB)

    C.F. Ahlers, H.H. Liu

    2001-12-18

    The purpose of this Analysis/Model Report (AMR) is to document the Calibrated Properties Model that provides calibrated parameter sets for unsaturated zone (UZ) flow and transport process models for the Yucca Mountain Site Characterization Project (YMP). This work was performed in accordance with the AMR Development Plan for U0035 Calibrated Properties Model REV00 (CRWMS M&O 1999c). These calibrated property sets include matrix and fracture parameters for the UZ Flow and Transport Model (UZ Model), drift seepage models, drift-scale and mountain-scale coupled-processes models, and Total System Performance Assessment (TSPA) models as well as Performance Assessment (PA) and other participating national laboratories and government agencies. These process models provide the necessary framework to test conceptual hypotheses of flow and transport at different scales and predict flow and transport behavior under a variety of climatic and thermal-loading conditions.

  13. The Hospitable Meal Model

    DEFF Research Database (Denmark)

    Justesen, Lise; Overgaard, Svend Skafte

    2017-01-01

    This article presents an analytical model that aims to conceptualize how meal experiences are framed when taking into account a dynamic understanding of hospitality: the meal model is named The Hospitable Meal Model. The idea behind The Hospitable Meal Model is to present a conceptual model...... that can serve as a frame for developing hospitable meal competencies among professionals working within the area of institutional foodservices as well as a conceptual model for analysing meal experiences. The Hospitable Meal Model transcends and transforms existing meal models by presenting a more open......-ended approach towards meal experiences. The underlying purpose of The Hospitable Meal Model is to provide the basis for creating value for the individuals involved in institutional meal services. The Hospitable Meal Model was developed on the basis of an empirical study on hospital meal experiences explored...

  14. MulensModel: Microlensing light curves modeling

    Science.gov (United States)

    Poleski, Radoslaw; Yee, Jennifer

    2018-03-01

    MulensModel calculates light curves of microlensing events. Both single and binary lens events are modeled and various higher-order effects can be included: extended source (with limb-darkening), annual microlensing parallax, and satellite microlensing parallax. The code is object-oriented and written in Python3, and requires AstroPy (ascl:1304.002).

  15. Business Models and Business Model Innovation

    DEFF Research Database (Denmark)

    Foss, Nicolai J.; Saebi, Tina

    2018-01-01

    While research on business models and business model innovation continue to exhibit growth, the field is still, even after more than two decades of research, characterized by a striking lack of cumulative theorizing and an opportunistic borrowing of more or less related ideas from neighbouring...

  16. EMC Simulation and Modeling

    Science.gov (United States)

    Takahashi, Takehiro; Schibuya, Noboru

    The EMC simulation is now widely used in design stage of electronic equipment to reduce electromagnetic noise. As the calculated electromagnetic behaviors of the EMC simulator depends on the inputted EMC model of the equipment, the modeling technique is important to obtain effective results. In this paper, simple outline of the EMC simulator and EMC model are described. Some modeling techniques of EMC simulation are also described with an example of the EMC model which is shield box with aperture.

  17. Phenomenology of inflationary models

    Science.gov (United States)

    Olyaei, Abbas

    2018-01-01

    There are many inflationary models compatible with observational data. One can investigate inflationary models by looking at their general features, which are common in most of the models. Here we have investigated some of the single-field models without considering their origin in order to find the phenomenology of them. We have shown how to adjust the simple harmonic oscillator model in order to be in good agreement with observational data.

  18. Multilevel statistical models

    CERN Document Server

    Goldstein, Harvey

    2011-01-01

    This book provides a clear introduction to this important area of statistics. The author provides a wide of coverage of different kinds of multilevel models, and how to interpret different statistical methodologies and algorithms applied to such models. This 4th edition reflects the growth and interest in this area and is updated to include new chapters on multilevel models with mixed response types, smoothing and multilevel data, models with correlated random effects and modeling with variance.

  19. Latent classification models

    DEFF Research Database (Denmark)

    Langseth, Helge; Nielsen, Thomas Dyhre

    2005-01-01

    parametric family ofdistributions.  In this paper we propose a new set of models forclassification in continuous domains, termed latent classificationmodels. The latent classification model can roughly be seen ascombining the \\NB model with a mixture of factor analyzers,thereby relaxing the assumptions...... classification model, and wedemonstrate empirically that the accuracy of the proposed model issignificantly higher than the accuracy of other probabilisticclassifiers....

  20. Geochemistry Model Validation Report: External Accumulation Model

    Energy Technology Data Exchange (ETDEWEB)

    K. Zarrabi

    2001-09-27

    The purpose of this Analysis and Modeling Report (AMR) is to validate the External Accumulation Model that predicts accumulation of fissile materials in fractures and lithophysae in the rock beneath a degrading waste package (WP) in the potential monitored geologic repository at Yucca Mountain. (Lithophysae are voids in the rock having concentric shells of finely crystalline alkali feldspar, quartz, and other materials that were formed due to entrapped gas that later escaped, DOE 1998, p. A-25.) The intended use of this model is to estimate the quantities of external accumulation of fissile material for use in external criticality risk assessments for different types of degrading WPs: U.S. Department of Energy (DOE) Spent Nuclear Fuel (SNF) codisposed with High Level Waste (HLW) glass, commercial SNF, and Immobilized Plutonium Ceramic (Pu-ceramic) codisposed with HLW glass. The scope of the model validation is to (1) describe the model and the parameters used to develop the model, (2) provide rationale for selection of the parameters by comparisons with measured values, and (3) demonstrate that the parameters chosen are the most conservative selection for external criticality risk calculations. To demonstrate the applicability of the model, a Pu-ceramic WP is used as an example. The model begins with a source term from separately documented EQ6 calculations; where the source term is defined as the composition versus time of the water flowing out of a breached waste package (WP). Next, PHREEQC, is used to simulate the transport and interaction of the source term with the resident water and fractured tuff below the repository. In these simulations the primary mechanism for accumulation is mixing of the high pH, actinide-laden source term with resident water; thus lowering the pH values sufficiently for fissile minerals to become insoluble and precipitate. In the final section of the model, the outputs from PHREEQC, are processed to produce mass of accumulation

  1. Geochemistry Model Validation Report: External Accumulation Model

    International Nuclear Information System (INIS)

    Zarrabi, K.

    2001-01-01

    The purpose of this Analysis and Modeling Report (AMR) is to validate the External Accumulation Model that predicts accumulation of fissile materials in fractures and lithophysae in the rock beneath a degrading waste package (WP) in the potential monitored geologic repository at Yucca Mountain. (Lithophysae are voids in the rock having concentric shells of finely crystalline alkali feldspar, quartz, and other materials that were formed due to entrapped gas that later escaped, DOE 1998, p. A-25.) The intended use of this model is to estimate the quantities of external accumulation of fissile material for use in external criticality risk assessments for different types of degrading WPs: U.S. Department of Energy (DOE) Spent Nuclear Fuel (SNF) codisposed with High Level Waste (HLW) glass, commercial SNF, and Immobilized Plutonium Ceramic (Pu-ceramic) codisposed with HLW glass. The scope of the model validation is to (1) describe the model and the parameters used to develop the model, (2) provide rationale for selection of the parameters by comparisons with measured values, and (3) demonstrate that the parameters chosen are the most conservative selection for external criticality risk calculations. To demonstrate the applicability of the model, a Pu-ceramic WP is used as an example. The model begins with a source term from separately documented EQ6 calculations; where the source term is defined as the composition versus time of the water flowing out of a breached waste package (WP). Next, PHREEQC, is used to simulate the transport and interaction of the source term with the resident water and fractured tuff below the repository. In these simulations the primary mechanism for accumulation is mixing of the high pH, actinide-laden source term with resident water; thus lowering the pH values sufficiently for fissile minerals to become insoluble and precipitate. In the final section of the model, the outputs from PHREEQC, are processed to produce mass of accumulation

  2. Crop rotation modelling - A European model intercomparison

    DEFF Research Database (Denmark)

    Kollas, Chris; Kersebaum, Kurt C; Nendel, Claas

    2015-01-01

    crop growth simulation models to predict yields in crop rotations at five sites across Europe under minimal calibration. Crop rotations encompassed 301 seasons of ten crop types common to European agriculture and a diverse set of treatments (irrigation, fertilisation, CO2 concentration, soil types...... accurately than main crops (cereals). The majority of models performed better for the treatments of increased CO2 and nitrogen fertilisation than for irrigation and soil-related treatments. The yield simulation of the multi-model ensemble reduced the error compared to single-model simulations. The low degree...... representation of crop rotations, further research is required to synthesise existing knowledge of the physiology of intermediate crops and of carry-over effects from the preceding to the following crop, and to implement/improve the modelling of processes that condition these effects....

  3. Modelling of an homogeneous equilibrium mixture model

    International Nuclear Information System (INIS)

    Bernard-Champmartin, A.; Poujade, O.; Mathiaud, J.; Mathiaud, J.; Ghidaglia, J.M.

    2014-01-01

    We present here a model for two phase flows which is simpler than the 6-equations models (with two densities, two velocities, two temperatures) but more accurate than the standard mixture models with 4 equations (with two densities, one velocity and one temperature). We are interested in the case when the two-phases have been interacting long enough for the drag force to be small but still not negligible. The so-called Homogeneous Equilibrium Mixture Model (HEM) that we present is dealing with both mixture and relative quantities, allowing in particular to follow both a mixture velocity and a relative velocity. This relative velocity is not tracked by a conservation law but by a closure law (drift relation), whose expression is related to the drag force terms of the two-phase flow. After the derivation of the model, a stability analysis and numerical experiments are presented. (authors)

  4. Model Reduction in Groundwater Modeling and Management

    Science.gov (United States)

    Siade, A. J.; Kendall, D. R.; Putti, M.; Yeh, W. W.

    2008-12-01

    Groundwater management requires the development and implementation of mathematical models that, through simulation, evaluate the effects of anthropogenic impacts on an aquifer system. To obtain high levels of accuracy, one must incorporate high levels of complexity, resulting in computationally demanding models. This study provides a methodology for solving groundwater management problems with reduced computational effort by replacing the large, complex numerical model with a significantly smaller, simpler approximation. This is achieved via Proper Orthogonal Decomposition (POD), where the goal is to project the larger model solution space onto a smaller or reduced subspace in which the management problem will be solved, achieving reductions in computation time of up to three orders of magnitude. Once the solution is obtained in the reduced space with acceptable accuracy, it is then projected back to the full model space. A major challenge when using this method is the definition of the reduced solution subspace. In POD, this subspace is defined based on samples or snapshots taken at specific times from the solution of the full model. In this work we determine when snapshots should be taken on the basis of the exponential behavior of the governing partial differential equation. This selection strategy is then generalized for any groundwater model by obtaining and using the optimal snapshot selection for a simplified, dimensionless model. Protocols are developed to allow the snapshot selection results of the simplified, dimensionless model to be transferred to that of a complex, heterogeneous model with any geometry. The proposed methodology is finally applied to a basin in the Oristano Plain located in the Sardinia Island, Italy.

  5. Model Validation Status Review

    International Nuclear Information System (INIS)

    E.L. Hardin

    2001-01-01

    The primary objective for the Model Validation Status Review was to perform a one-time evaluation of model validation associated with the analysis/model reports (AMRs) containing model input to total-system performance assessment (TSPA) for the Yucca Mountain site recommendation (SR). This review was performed in response to Corrective Action Request BSC-01-C-01 (Clark 2001, Krisha 2001) pursuant to Quality Assurance review findings of an adverse trend in model validation deficiency. The review findings in this report provide the following information which defines the extent of model validation deficiency and the corrective action needed: (1) AMRs that contain or support models are identified, and conversely, for each model the supporting documentation is identified. (2) The use for each model is determined based on whether the output is used directly for TSPA-SR, or for screening (exclusion) of features, events, and processes (FEPs), and the nature of the model output. (3) Two approaches are used to evaluate the extent to which the validation for each model is compliant with AP-3.10Q (Analyses and Models). The approaches differ in regard to whether model validation is achieved within individual AMRs as originally intended, or whether model validation could be readily achieved by incorporating information from other sources. (4) Recommendations are presented for changes to the AMRs, and additional model development activities or data collection, that will remedy model validation review findings, in support of licensing activities. The Model Validation Status Review emphasized those AMRs that support TSPA-SR (CRWMS M and O 2000bl and 2000bm). A series of workshops and teleconferences was held to discuss and integrate the review findings. The review encompassed 125 AMRs (Table 1) plus certain other supporting documents and data needed to assess model validity. The AMRs were grouped in 21 model areas representing the modeling of processes affecting the natural and

  6. Model Validation Status Review

    Energy Technology Data Exchange (ETDEWEB)

    E.L. Hardin

    2001-11-28

    The primary objective for the Model Validation Status Review was to perform a one-time evaluation of model validation associated with the analysis/model reports (AMRs) containing model input to total-system performance assessment (TSPA) for the Yucca Mountain site recommendation (SR). This review was performed in response to Corrective Action Request BSC-01-C-01 (Clark 2001, Krisha 2001) pursuant to Quality Assurance review findings of an adverse trend in model validation deficiency. The review findings in this report provide the following information which defines the extent of model validation deficiency and the corrective action needed: (1) AMRs that contain or support models are identified, and conversely, for each model the supporting documentation is identified. (2) The use for each model is determined based on whether the output is used directly for TSPA-SR, or for screening (exclusion) of features, events, and processes (FEPs), and the nature of the model output. (3) Two approaches are used to evaluate the extent to which the validation for each model is compliant with AP-3.10Q (Analyses and Models). The approaches differ in regard to whether model validation is achieved within individual AMRs as originally intended, or whether model validation could be readily achieved by incorporating information from other sources. (4) Recommendations are presented for changes to the AMRs, and additional model development activities or data collection, that will remedy model validation review findings, in support of licensing activities. The Model Validation Status Review emphasized those AMRs that support TSPA-SR (CRWMS M&O 2000bl and 2000bm). A series of workshops and teleconferences was held to discuss and integrate the review findings. The review encompassed 125 AMRs (Table 1) plus certain other supporting documents and data needed to assess model validity. The AMRs were grouped in 21 model areas representing the modeling of processes affecting the natural and

  7. Modeling for Battery Prognostics

    Science.gov (United States)

    Kulkarni, Chetan S.; Goebel, Kai; Khasin, Michael; Hogge, Edward; Quach, Patrick

    2017-01-01

    For any battery-powered vehicles (be it unmanned aerial vehicles, small passenger aircraft, or assets in exoplanetary operations) to operate at maximum efficiency and reliability, it is critical to monitor battery health as well performance and to predict end of discharge (EOD) and end of useful life (EOL). To fulfil these needs, it is important to capture the battery's inherent characteristics as well as operational knowledge in the form of models that can be used by monitoring, diagnostic, and prognostic algorithms. Several battery modeling methodologies have been developed in last few years as the understanding of underlying electrochemical mechanics has been advancing. The models can generally be classified as empirical models, electrochemical engineering models, multi-physics models, and molecular/atomist. Empirical models are based on fitting certain functions to past experimental data, without making use of any physicochemical principles. Electrical circuit equivalent models are an example of such empirical models. Electrochemical engineering models are typically continuum models that include electrochemical kinetics and transport phenomena. Each model has its advantages and disadvantages. The former type of model has the advantage of being computationally efficient, but has limited accuracy and robustness, due to the approximations used in developed model, and as a result of such approximations, cannot represent aging well. The latter type of model has the advantage of being very accurate, but is often computationally inefficient, having to solve complex sets of partial differential equations, and thus not suited well for online prognostic applications. In addition both multi-physics and atomist models are computationally expensive hence are even less suited to online application An electrochemistry-based model of Li-ion batteries has been developed, that captures crucial electrochemical processes, captures effects of aging, is computationally efficient

  8. Dimension of linear models

    DEFF Research Database (Denmark)

    Høskuldsson, Agnar

    1996-01-01

    Determination of the proper dimension of a given linear model is one of the most important tasks in the applied modeling work. We consider here eight criteria that can be used to determine the dimension of the model, or equivalently, the number of components to use in the model. Four of these cri......Determination of the proper dimension of a given linear model is one of the most important tasks in the applied modeling work. We consider here eight criteria that can be used to determine the dimension of the model, or equivalently, the number of components to use in the model. Four...... the basic problems in determining the dimension of linear models. Then each of the eight measures are treated. The results are illustrated by examples....

  9. Product and Process Modelling

    DEFF Research Database (Denmark)

    Cameron, Ian T.; Gani, Rafiqul

    This book covers the area of product and process modelling via a case study approach. It addresses a wide range of modelling applications with emphasis on modelling methodology and the subsequent in-depth analysis of mathematical models to gain insight via structural aspects of the models....... These approaches are put into the context of life cycle modelling, where multiscale and multiform modelling is increasingly prevalent in the 21st century. The book commences with a discussion of modern product and process modelling theory and practice followed by a series of case studies drawn from a variety...... to biotechnology applications, food, polymer and human health application areas. The book highlights to important nature of modern product and process modelling in the decision making processes across the life cycle. As such it provides an important resource for students, researchers and industrial practitioners....

  10. Modeling volatility using state space models.

    Science.gov (United States)

    Timmer, J; Weigend, A S

    1997-08-01

    In time series problems, noise can be divided into two categories: dynamic noise which drives the process, and observational noise which is added in the measurement process, but does not influence future values of the system. In this framework, we show that empirical volatilities (the squared relative returns of prices) exhibit a significant amount of observational noise. To model and predict their time evolution adequately, we estimate state space models that explicitly include observational noise. We obtain relaxation times for shocks in the logarithm of volatility ranging from three weeks (for foreign exchange) to three to five months (for stock indices). In most cases, a two-dimensional hidden state is required to yield residuals that are consistent with white noise. We compare these results with ordinary autoregressive models (without a hidden state) and find that autoregressive models underestimate the relaxation times by about two orders of magnitude since they do not distinguish between observational and dynamic noise. This new interpretation of the dynamics of volatility in terms of relaxators in a state space model carries over to stochastic volatility models and to GARCH models, and is useful for several problems in finance, including risk management and the pricing of derivative securities. Data sets used: Olsen & Associates high frequency DEM/USD foreign exchange rates (8 years). Nikkei 225 index (40 years). Dow Jones Industrial Average (25 years).

  11. Empirical Model Building Data, Models, and Reality

    CERN Document Server

    Thompson, James R

    2011-01-01

    Praise for the First Edition "This...novel and highly stimulating book, which emphasizes solving real problems...should be widely read. It will have a positive and lasting effect on the teaching of modeling and statistics in general." - Short Book Reviews This new edition features developments and real-world examples that showcase essential empirical modeling techniques Successful empirical model building is founded on the relationship between data and approximate representations of the real systems that generated that data. As a result, it is essential for researchers who construct these m

  12. Zephyr - the prediction models

    DEFF Research Database (Denmark)

    Nielsen, Torben Skov; Madsen, Henrik; Nielsen, Henrik Aalborg

    2001-01-01

    utilities as partners and users. The new models are evaluated for five wind farms in Denmark as well as one wind farm in Spain. It is shown that the predictions based on conditional parametric models are superior to the predictions obatined by state-of-the-art parametric models.......This paper briefly describes new models and methods for predicationg the wind power output from wind farms. The system is being developed in a project which has the research organization Risø and the department of Informatics and Mathematical Modelling (IMM) as the modelling team and all the Danish...

  13. Models of light nuclei

    International Nuclear Information System (INIS)

    Harvey, M.; Khanna, F.C.

    1975-01-01

    The general problem of what constitutes a physical model and what is known about the free nucleon-nucleon interaction are considered. A time independent formulation of the basic equations is chosen. Construction of the average field in which particles move in a general independent particle model is developed, concentrating on problems of defining the average spherical single particle field for any given nucleus, and methods for construction of effective residual interactions and other physical operators. Deformed shell models and both spherical and deformed harmonic oscillator models are discussed in detail, and connections between spherical and deformed shell models are analyzed. A section on cluster models is included. 11 tables, 21 figures

  14. Building Thermal Models

    Science.gov (United States)

    Peabody, Hume L.

    2017-01-01

    This presentation is meant to be an overview of the model building process It is based on typical techniques (Monte Carlo Ray Tracing for radiation exchange, Lumped Parameter, Finite Difference for thermal solution) used by the aerospace industry This is not intended to be a "How to Use ThermalDesktop" course. It is intended to be a "How to Build Thermal Models" course and the techniques will be demonstrated using the capabilities of ThermalDesktop (TD). Other codes may or may not have similar capabilities. The General Model Building Process can be broken into four top level steps: 1. Build Model; 2. Check Model; 3. Execute Model; 4. Verify Results.

  15. Microsoft tabular modeling cookbook

    CERN Document Server

    Braak, Paul te

    2013-01-01

    This book follows a cookbook style with recipes explaining the steps for developing analytic data using Business Intelligence Semantic Models.This book is designed for developers who wish to develop powerful and dynamic models for users as well as those who are responsible for the administration of models in corporate environments. It is also targeted at analysts and users of Excel who wish to advance their knowledge of Excel through the development of tabular models or who wish to analyze data through tabular modeling techniques. We assume no prior knowledge of tabular modeling

  16. Five models of capitalism

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Bresser-Pereira

    2012-03-01

    Full Text Available Besides analyzing capitalist societies historically and thinking of them in terms of phases or stages, we may compare different models or varieties of capitalism. In this paper I survey the literature on this subject, and distinguish the classification that has a production or business approach from those that use a mainly political criterion. I identify five forms of capitalism: among the rich countries, the liberal democratic or Anglo-Saxon model, the social or European model, and the endogenous social integration or Japanese model; among developing countries, I distinguish the Asian developmental model from the liberal-dependent model that characterizes most other developing countries, including Brazil.

  17. Holographic twin Higgs model.

    Science.gov (United States)

    Geller, Michael; Telem, Ofri

    2015-05-15

    We present the first realization of a "twin Higgs" model as a holographic composite Higgs model. Uniquely among composite Higgs models, the Higgs potential is protected by a new standard model (SM) singlet elementary "mirror" sector at the sigma model scale f and not by the composite states at m_{KK}, naturally allowing for m_{KK} beyond the LHC reach. As a result, naturalness in our model cannot be constrained by the LHC, but may be probed by precision Higgs measurements at future lepton colliders, and by direct searches for Kaluza-Klein excitations at a 100 TeV collider.

  18. Biosphere Model Report

    Energy Technology Data Exchange (ETDEWEB)

    D.W. Wu; A.J. Smith

    2004-11-08

    The purpose of this report is to document the biosphere model, the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), which describes radionuclide transport processes in the biosphere and associated human exposure that may arise as the result of radionuclide release from the geologic repository at Yucca Mountain. The biosphere model is one of the process models that support the Yucca Mountain Project (YMP) Total System Performance Assessment (TSPA) for the license application (LA), TSPA-LA. The ERMYN provides the capability of performing human radiation dose assessments. This report documents the biosphere model, which includes: (1) Describing the reference biosphere, human receptor, exposure scenarios, and primary radionuclides for each exposure scenario (Section 6.1); (2) Developing a biosphere conceptual model using site-specific features, events, and processes (FEPs) (Section 6.2), the reference biosphere (Section 6.1.1), the human receptor (Section 6.1.2), and approximations (Sections 6.3.1.4 and 6.3.2.4); (3) Building a mathematical model using the biosphere conceptual model (Section 6.3) and published biosphere models (Sections 6.4 and 6.5); (4) Summarizing input parameters for the mathematical model, including the uncertainty associated with input values (Section 6.6); (5) Identifying improvements in the ERMYN compared with the model used in previous biosphere modeling (Section 6.7); (6) Constructing an ERMYN implementation tool (model) based on the biosphere mathematical model using GoldSim stochastic simulation software (Sections 6.8 and 6.9); (7) Verifying the ERMYN by comparing output from the software with hand calculations to ensure that the GoldSim implementation is correct (Section 6.10); (8) Validating the ERMYN by corroborating it with published biosphere models; comparing conceptual models, mathematical models, and numerical results (Section 7).

  19. Biosphere Model Report

    International Nuclear Information System (INIS)

    D.W. Wu; A.J. Smith

    2004-01-01

    The purpose of this report is to document the biosphere model, the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), which describes radionuclide transport processes in the biosphere and associated human exposure that may arise as the result of radionuclide release from the geologic repository at Yucca Mountain. The biosphere model is one of the process models that support the Yucca Mountain Project (YMP) Total System Performance Assessment (TSPA) for the license application (LA), TSPA-LA. The ERMYN provides the capability of performing human radiation dose assessments. This report documents the biosphere model, which includes: (1) Describing the reference biosphere, human receptor, exposure scenarios, and primary radionuclides for each exposure scenario (Section 6.1); (2) Developing a biosphere conceptual model using site-specific features, events, and processes (FEPs) (Section 6.2), the reference biosphere (Section 6.1.1), the human receptor (Section 6.1.2), and approximations (Sections 6.3.1.4 and 6.3.2.4); (3) Building a mathematical model using the biosphere conceptual model (Section 6.3) and published biosphere models (Sections 6.4 and 6.5); (4) Summarizing input parameters for the mathematical model, including the uncertainty associated with input values (Section 6.6); (5) Identifying improvements in the ERMYN compared with the model used in previous biosphere modeling (Section 6.7); (6) Constructing an ERMYN implementation tool (model) based on the biosphere mathematical model using GoldSim stochastic simulation software (Sections 6.8 and 6.9); (7) Verifying the ERMYN by comparing output from the software with hand calculations to ensure that the GoldSim implementation is correct (Section 6.10); (8) Validating the ERMYN by corroborating it with published biosphere models; comparing conceptual models, mathematical models, and numerical results (Section 7)

  20. Modelling of Innovation Diffusion

    Directory of Open Access Journals (Sweden)

    Arkadiusz Kijek

    2010-01-01

    Full Text Available Since the publication of the Bass model in 1969, research on the modelling of the diffusion of innovation resulted in a vast body of scientific literature consisting of articles, books, and studies of real-world applications of this model. The main objective of the diffusion model is to describe a pattern of spread of innovation among potential adopters in terms of a mathematical function of time. This paper assesses the state-of-the-art in mathematical models of innovation diffusion and procedures for estimating their parameters. Moreover, theoretical issues related to the models presented are supplemented with empirical research. The purpose of the research is to explore the extent to which the diffusion of broadband Internet users in 29 OECD countries can be adequately described by three diffusion models, i.e. the Bass model, logistic model and dynamic model. The results of this research are ambiguous and do not indicate which model best describes the diffusion pattern of broadband Internet users but in terms of the results presented, in most cases the dynamic model is inappropriate for describing the diffusion pattern. Issues related to the further development of innovation diffusion models are discussed and some recommendations are given. (original abstract

  1. Lie Markov models.

    Science.gov (United States)

    Sumner, J G; Fernández-Sánchez, J; Jarvis, P D

    2012-04-07

    Recent work has discussed the importance of multiplicative closure for the Markov models used in phylogenetics. For continuous-time Markov chains, a sufficient condition for multiplicative closure of a model class is ensured by demanding that the set of rate-matrices belonging to the model class form a Lie algebra. It is the case that some well-known Markov models do form Lie algebras and we refer to such models as "Lie Markov models". However it is also the case that some other well-known Markov models unequivocally do not form Lie algebras (GTR being the most conspicuous example). In this paper, we will discuss how to generate Lie Markov models by demanding that the models have certain symmetries under nucleotide permutations. We show that the Lie Markov models include, and hence provide a unifying concept for, "group-based" and "equivariant" models. For each of two and four character states, the full list of Lie Markov models with maximal symmetry is presented and shown to include interesting examples that are neither group-based nor equivariant. We also argue that our scheme is pleasing in the context of applied phylogenetics, as, for a given symmetry of nucleotide substitution, it provides a natural hierarchy of models with increasing number of parameters. We also note that our methods are applicable to any application of continuous-time Markov chains beyond the initial motivations we take from phylogenetics. Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.

  2. Integrated Medical Model – Chest Injury Model

    Data.gov (United States)

    National Aeronautics and Space Administration — The Exploration Medical Capability (ExMC) Element of NASA's Human Research Program (HRP) developed the Integrated Medical Model (IMM) to forecast the resources...

  3. Traffic & safety statewide model and GIS modeling.

    Science.gov (United States)

    2012-07-01

    Several steps have been taken over the past two years to advance the Utah Department of Transportation (UDOT) safety initiative. Previous research projects began the development of a hierarchical Bayesian model to analyze crashes on Utah roadways. De...

  4. Nonlinear Modeling by Assembling Piecewise Linear Models

    Science.gov (United States)

    Yao, Weigang; Liou, Meng-Sing

    2013-01-01

    To preserve nonlinearity of a full order system over a parameters range of interest, we propose a simple modeling approach by assembling a set of piecewise local solutions, including the first-order Taylor series terms expanded about some sampling states. The work by Rewienski and White inspired our use of piecewise linear local solutions. The assembly of these local approximations is accomplished by assigning nonlinear weights, through radial basis functions in this study. The efficacy of the proposed procedure is validated for a two-dimensional airfoil moving at different Mach numbers and pitching motions, under which the flow exhibits prominent nonlinear behaviors. All results confirm that our nonlinear model is accurate and stable for predicting not only aerodynamic forces but also detailed flowfields. Moreover, the model is robustness-accurate for inputs considerably different from the base trajectory in form and magnitude. This modeling preserves nonlinearity of the problems considered in a rather simple and accurate manner.

  5. Solid Waste Projection Model: Model user's guide

    International Nuclear Information System (INIS)

    Stiles, D.L.; Crow, V.L.

    1990-08-01

    The Solid Waste Projection Model (SWPM) system is an analytical tool developed by Pacific Northwest Laboratory (PNL) for Westinghouse Hanford company (WHC) specifically to address solid waste management issues at the Hanford Central Waste Complex (HCWC). This document, one of six documents supporting the SWPM system, contains a description of the system and instructions for preparing to use SWPM and operating Version 1 of the model. 4 figs., 1 tab

  6. Modeling of System Families

    National Research Council Canada - National Science Library

    Feiler, Peter

    2007-01-01

    .... The Society of Automotive Engineers (SAE) Architecture Analysis & Design Language (AADL) is an industry-standard, architecture-modeling notation specifically designed to support a component- based approach to modeling embedded systems...

  7. Models in Action

    DEFF Research Database (Denmark)

    Juhl, Joakim

    This thesis is about mathematical modelling and technology development. While mathematical modelling has become widely deployed within a broad range of scientific practices, it has also gained a central position within technology development. The intersection of mathematical modelling......-efficiency project, this thesis presents an analysis of the central practices that materialised representative physical modelling and implemented operational regulation models. In order to show how the project’s representative modelling and technology development connected physical theory with concrete problems...... theoretical outset, the existing literature on simulation models, and the study’s methodological and empirical approach. The purpose of this thesis is to describe the central practices that developed regulation technology for industrial production processes and to analyse how mathematical modelling...

  8. CCF model comparison

    International Nuclear Information System (INIS)

    Pulkkinen, U.

    2004-04-01

    The report describes a simple comparison of two CCF-models, the ECLM, and the Beta-model. The objective of the comparison is to identify differences in the results of the models by applying the models in some simple test data cases. The comparison focuses mainly on theoretical aspects of the above mentioned CCF-models. The properties of the model parameter estimates in the data cases is also discussed. The practical aspects in using and estimating CCFmodels in real PSA context (e.g. the data interpretation, properties of computer tools, the model documentation) are not discussed in the report. Similarly, the qualitative CCF-analyses needed in using the models are not discussed in the report. (au)

  9. Modeling EERE deployment programs

    Energy Technology Data Exchange (ETDEWEB)

    Cort, K. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hostick, D. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Belzer, D. B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Livingston, O. V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2007-11-01

    The purpose of the project was to identify and characterize the modeling of deployment programs within the EERE Technology Development (TD) programs, address possible improvements to the modeling process, and note gaps in knowledge for future research.

  10. Controlling Modelling Artifacts

    DEFF Research Database (Denmark)

    Smith, Michael James Andrew; Nielson, Flemming; Nielson, Hanne Riis

    2011-01-01

    the possible configurations of the system (for example, by counting the number of components in a certain state). We motivate our methodology with a case study of the LMAC protocol for wireless sensor networks. In particular, we investigate the accuracy of a recently proposed high-level model of LMAC......When analysing the performance of a complex system, we typically build abstract models that are small enough to analyse, but still capture the relevant details of the system. But it is difficult to know whether the model accurately describes the real system, or if its behaviour is due to modelling...... artifacts that were inadvertently introduced. In this paper, we propose a novel methodology to reason about modelling artifacts, given a detailed model and a highlevel (more abstract) model of the same system. By a series of automated abstraction steps, we lift the detailed model to the same state space...

  11. Modeling Fluid Structure Interaction

    National Research Council Canada - National Science Library

    Benaroya, Haym

    2000-01-01

    The principal goal of this program is on integrating experiments with analytical modeling to develop physics-based reduced-order analytical models of nonlinear fluid-structure interactions in articulated naval platforms...

  12. Consistent model driven architecture

    Science.gov (United States)

    Niepostyn, Stanisław J.

    2015-09-01

    The goal of the MDA is to produce software systems from abstract models in a way where human interaction is restricted to a minimum. These abstract models are based on the UML language. However, the semantics of UML models is defined in a natural language. Subsequently the verification of consistency of these diagrams is needed in order to identify errors in requirements at the early stage of the development process. The verification of consistency is difficult due to a semi-formal nature of UML diagrams. We propose automatic verification of consistency of the series of UML diagrams originating from abstract models implemented with our consistency rules. This Consistent Model Driven Architecture approach enables us to generate automatically complete workflow applications from consistent and complete models developed from abstract models (e.g. Business Context Diagram). Therefore, our method can be used to check practicability (feasibility) of software architecture models.

  13. Protein solubility modeling

    Science.gov (United States)

    Agena, S. M.; Pusey, M. L.; Bogle, I. D.

    1999-01-01

    A thermodynamic framework (UNIQUAC model with temperature dependent parameters) is applied to model the salt-induced protein crystallization equilibrium, i.e., protein solubility. The framework introduces a term for the solubility product describing protein transfer between the liquid and solid phase and a term for the solution behavior describing deviation from ideal solution. Protein solubility is modeled as a function of salt concentration and temperature for a four-component system consisting of a protein, pseudo solvent (water and buffer), cation, and anion (salt). Two different systems, lysozyme with sodium chloride and concanavalin A with ammonium sulfate, are investigated. Comparison of the modeled and experimental protein solubility data results in an average root mean square deviation of 5.8%, demonstrating that the model closely follows the experimental behavior. Model calculations and model parameters are reviewed to examine the model and protein crystallization process. Copyright 1999 John Wiley & Sons, Inc.

  14. Model and code development

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    Progress in model and code development for reactor physics calculations is summarized. The codes included CINDER-10, PHROG, RAFFLE GAPP, DCFMR, RELAP/4, PARET, and KENO. Kinetics models for the PBF were developed

  15. LAT Background Models

    Data.gov (United States)

    National Aeronautics and Space Administration — The Galactic model is a spatial and spectral template. The model for the Galactic diffuse emission was developed using spectral line surveys of HI and CO (as a...

  16. World Magnetic Model 2015

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The World Magnetic Model is the standard model used by the U.S. Department of Defense, the U.K. Ministry of Defence, the North Atlantic Treaty Organization (NATO)...

  17. The ATLAS Analysis Model

    CERN Multimedia

    Amir Farbin

    The ATLAS Analysis Model is a continually developing vision of how to reconcile physics analysis requirements with the ATLAS offline software and computing model constraints. In the past year this vision has influenced the evolution of the ATLAS Event Data Model, the Athena software framework, and physics analysis tools. These developments, along with the October Analysis Model Workshop and the planning for CSC analyses have led to a rapid refinement of the ATLAS Analysis Model in the past few months. This article introduces some of the relevant issues and presents the current vision of the future ATLAS Analysis Model. Event Data Model The ATLAS Event Data Model (EDM) consists of several levels of details, each targeted for a specific set of tasks. For example the Event Summary Data (ESD) stores calorimeter cells and tracking system hits thereby permitting many calibration and alignment tasks, but will be only accessible at particular computing sites with potentially large latency. In contrast, the Analysis...

  18. World Magnetic Model 2010

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The World Magnetic Model is the standard model used by the U.S. Department of Defense, the U.K. Ministry of Defence, the North Atlantic Treaty Organization (NATO)...

  19. ASC Champ Orbit Model

    DEFF Research Database (Denmark)

    Riis, Troels; Jørgensen, John Leif

    1999-01-01

    This documents describes a test of the implementation of the ASC orbit model for the Champ satellite.......This documents describes a test of the implementation of the ASC orbit model for the Champ satellite....

  20. Laboratory of Biological Modeling

    Data.gov (United States)

    Federal Laboratory Consortium — The Laboratory of Biological Modeling is defined by both its methodologies and its areas of application. We use mathematical modeling in many forms and apply it to a...

  1. Bounding species distribution models

    Directory of Open Access Journals (Sweden)

    Thomas J. STOHLGREN, Catherine S. JARNEVICH, Wayne E. ESAIAS,Jeffrey T. MORISETTE

    2011-10-01

    Full Text Available Species distribution models are increasing in popularity for mapping suitable habitat for species of management concern. Many investigators now recognize that extrapolations of these models with geographic information systems (GIS might be sensitive to the environmental bounds of the data used in their development, yet there is no recommended best practice for “clamping” model extrapolations. We relied on two commonly used modeling approaches: classification and regression tree (CART and maximum entropy (Maxent models, and we tested a simple alteration of the model extrapolations, bounding extrapolations to the maximum and minimum values of primary environmental predictors, to provide a more realistic map of suitable habitat of hybridized Africanized honey bees in the southwestern United States. Findings suggest that multiple models of bounding, and the most conservative bounding of species distribution models, like those presented here, should probably replace the unbounded or loosely bounded techniques currently used [Current Zoology 57 (5: 642–647, 2011].

  2. Bounding Species Distribution Models

    Science.gov (United States)

    Stohlgren, Thomas J.; Jarnevich, Cahterine S.; Morisette, Jeffrey T.; Esaias, Wayne E.

    2011-01-01

    Species distribution models are increasing in popularity for mapping suitable habitat for species of management concern. Many investigators now recognize that extrapolations of these models with geographic information systems (GIS) might be sensitive to the environmental bounds of the data used in their development, yet there is no recommended best practice for "clamping" model extrapolations. We relied on two commonly used modeling approaches: classification and regression tree (CART) and maximum entropy (Maxent) models, and we tested a simple alteration of the model extrapolations, bounding extrapolations to the maximum and minimum values of primary environmental predictors, to provide a more realistic map of suitable habitat of hybridized Africanized honey bees in the southwestern United States. Findings suggest that multiple models of bounding, and the most conservative bounding of species distribution models, like those presented here, should probably replace the unbounded or loosely bounded techniques currently used [Current Zoology 57 (5): 642-647, 2011].

  3. Modeling Complex Time Limits

    Directory of Open Access Journals (Sweden)

    Oleg Svatos

    2013-01-01

    Full Text Available In this paper we analyze complexity of time limits we can find especially in regulated processes of public administration. First we review the most popular process modeling languages. There is defined an example scenario based on the current Czech legislature which is then captured in discussed process modeling languages. Analysis shows that the contemporary process modeling languages support capturing of the time limit only partially. This causes troubles to analysts and unnecessary complexity of the models. Upon unsatisfying results of the contemporary process modeling languages we analyze the complexity of the time limits in greater detail and outline lifecycles of a time limit using the multiple dynamic generalizations pattern. As an alternative to the popular process modeling languages there is presented PSD process modeling language, which supports the defined lifecycles of a time limit natively and therefore allows keeping the models simple and easy to understand.

  4. Emissions Modeling Clearinghouse

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Emissions Modeling Clearinghouse (EMCH) supports and promotes emissions modeling activities both internal and external to the EPA. Through this site, the EPA...

  5. Differential models in ecology

    International Nuclear Information System (INIS)

    Barco Gomez, Carlos; Barco Gomez, German

    2002-01-01

    The models mathematical writings with differential equations are used to describe the populational behavior through the time of the animal species. These models can be lineal or no lineal. The differential models for unique specie include the exponential pattern of Malthus and the logistical pattern of Verlhust. The lineal differential models to describe the interaction between two species include the competition relationships, predation and symbiosis

  6. Hierarchical Bass model

    Science.gov (United States)

    Tashiro, Tohru

    2014-03-01

    We propose a new model about diffusion of a product which includes a memory of how many adopters or advertisements a non-adopter met, where (non-)adopters mean people (not) possessing the product. This effect is lacking in the Bass model. As an application, we utilize the model to fit the iPod sales data, and so the better agreement is obtained than the Bass model.

  7. GARCH Modelling of Cryptocurrencies

    Directory of Open Access Journals (Sweden)

    Jeffrey Chu

    2017-10-01

    Full Text Available With the exception of Bitcoin, there appears to be little or no literature on GARCH modelling of cryptocurrencies. This paper provides the first GARCH modelling of the seven most popular cryptocurrencies. Twelve GARCH models are fitted to each cryptocurrency, and their fits are assessed in terms of five criteria. Conclusions are drawn on the best fitting models, forecasts and acceptability of value at risk estimates.

  8. Cloud Model Bat Algorithm

    OpenAIRE

    Yongquan Zhou; Jian Xie; Liangliang Li; Mingzhi Ma

    2014-01-01

    Bat algorithm (BA) is a novel stochastic global optimization algorithm. Cloud model is an effective tool in transforming between qualitative concepts and their quantitative representation. Based on the bat echolocation mechanism and excellent characteristics of cloud model on uncertainty knowledge representation, a new cloud model bat algorithm (CBA) is proposed. This paper focuses on remodeling echolocation model based on living and preying characteristics of bats, utilizing the transformati...

  9. Optimization modeling with spreadsheets

    CERN Document Server

    Baker, Kenneth R

    2015-01-01

    An accessible introduction to optimization analysis using spreadsheets Updated and revised, Optimization Modeling with Spreadsheets, Third Edition emphasizes model building skills in optimization analysis. By emphasizing both spreadsheet modeling and optimization tools in the freely available Microsoft® Office Excel® Solver, the book illustrates how to find solutions to real-world optimization problems without needing additional specialized software. The Third Edition includes many practical applications of optimization models as well as a systematic framework that il

  10. Artificial neural network modelling

    CERN Document Server

    Samarasinghe, Sandhya

    2016-01-01

    This book covers theoretical aspects as well as recent innovative applications of Artificial Neural networks (ANNs) in natural, environmental, biological, social, industrial and automated systems. It presents recent results of ANNs in modelling small, large and complex systems under three categories, namely, 1) Networks, Structure Optimisation, Robustness and Stochasticity 2) Advances in Modelling Biological and Environmental Systems and 3) Advances in Modelling Social and Economic Systems. The book aims at serving undergraduates, postgraduates and researchers in ANN computational modelling. .

  11. TENCompetence Domain Model

    NARCIS (Netherlands)

    2006-01-01

    This is the version 1.1 of the TENCompetence Domain Model (version 1.0 released at 19-6-2006; version 1.1 at 9-11-2008). It contains several files: a) a pdf with the model description, b) three jpg files with class models (also in the pdf), c) a MagicDraw zip file with the model itself, d) a release

  12. Photovoltaic sources modeling

    CERN Document Server

    Petrone, Giovanni; Spagnuolo, Giovanni

    2016-01-01

    This comprehensive guide surveys all available models for simulating a photovoltaic (PV) generator at different levels of granularity, from cell to system level, in uniform as well as in mismatched conditions. Providing a thorough comparison among the models, engineers have all the elements needed to choose the right PV array model for specific applications or environmental conditions matched with the model of the electronic circuit used to maximize the PV power production.

  13. Hierarchical Bass model

    International Nuclear Information System (INIS)

    Tashiro, Tohru

    2014-01-01

    We propose a new model about diffusion of a product which includes a memory of how many adopters or advertisements a non-adopter met, where (non-)adopters mean people (not) possessing the product. This effect is lacking in the Bass model. As an application, we utilize the model to fit the iPod sales data, and so the better agreement is obtained than the Bass model

  14. Calibrated Properties Model

    Energy Technology Data Exchange (ETDEWEB)

    J. Wang

    2003-06-24

    The purpose of this Model Report is to document the Calibrated Properties Model that provides calibrated parameter sets for unsaturated zone (UZ) flow and transport process models for the Office of Repository Development (ORD). The UZ contains the unsaturated rock layers overlying the repository and host unit, which constitute a natural barrier to flow, and the unsaturated rock layers below the repository which constitute a natural barrier to flow and transport. This work followed, and was planned in, ''Technical Work Plan (TWP) for: Performance Assessment Unsaturated Zone'' (BSC 2002 [160819], Section 1.10.8 [under Work Package (WP) AUZM06, Climate Infiltration and Flow], and Section I-1-1 [in Attachment I, Model Validation Plans]). In Section 4.2, four acceptance criteria (ACs) are identified for acceptance of this Model Report; only one of these (Section 4.2.1.3.6.3, AC 3) was identified in the TWP (BSC 2002 [160819], Table 3-1). These calibrated property sets include matrix and fracture parameters for the UZ Flow and Transport Model (UZ Model), drift seepage models, and drift-scale and mountain-scale coupled-process models from the UZ Flow, Transport and Coupled Processes Department in the Natural Systems Subproject of the Performance Assessment (PA) Project. The Calibrated Properties Model output will also be used by the Engineered Barrier System Department in the Engineering Systems Subproject. The Calibrated Properties Model provides input through the UZ Model and other process models of natural and engineered systems to the Total System Performance Assessment (TSPA) models, in accord with the PA Strategy and Scope in the PA Project of the Bechtel SAIC Company, LLC (BSC). The UZ process models provide the necessary framework to test conceptual hypotheses of flow and transport at different scales and predict flow and transport behavior under a variety of climatic and thermal-loading conditions. UZ flow is a TSPA model component.

  15. Making business models

    DEFF Research Database (Denmark)

    Gudiksen, Sune Klok; Poulsen, Søren Bolvig; Buur, Jacob

    2014-01-01

    Well-established companies are currently struggling to secure profits due to the pressure from new players' business models as they take advantage of communication technology and new business-model configurations. Because of this, the business model research field flourishes currently; however, t...... illustrates how the application of participatory business model design toolsets can open up discussions on alternative scenarios through improvisation, mock-up making and design game playing, before qualitative judgment on the most promising scenario is carried out....

  16. Model Checking Feature Interactions

    DEFF Research Database (Denmark)

    Le Guilly, Thibaut; Olsen, Petur; Pedersen, Thomas

    2015-01-01

    This paper presents an offline approach to analyzing feature interactions in embedded systems. The approach consists of a systematic process to gather the necessary information about system components and their models. The model is first specified in terms of predicates, before being refined to t...... to timed automata. The consistency of the model is verified at different development stages, and the correct linkage between the predicates and their semantic model is checked. The approach is illustrated on a use case from home automation....

  17. Modelling of Corrosion Cracks

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    Modelling of corrosion cracking of reinforced concrete structures is complicated as a great number of uncertain factors are involved. To get a reliable modelling a physical and mechanical understanding of the process behind corrosion in needed.......Modelling of corrosion cracking of reinforced concrete structures is complicated as a great number of uncertain factors are involved. To get a reliable modelling a physical and mechanical understanding of the process behind corrosion in needed....

  18. The interaction of antimicrobial peptides with the membrane and intracellular targets of Staphylococcus aureus investigated by ATP leakage, DNA-binding analysis, and the expression of a LexA-controlled gene, recA

    DEFF Research Database (Denmark)

    Gottschalk, Sanne; Thomsen, Line Elnif

    2017-01-01

    The analysis of how antimicrobial peptides (AMPs) interact with bacterial membranes and intracellular targets is important for our understanding of how these molecules affect bacteria. Increased knowledge may aid the design of AMPs that work on their target bacterium without inducing bacterial re...

  19. Od duchovního společenství k ozdobě: Lexémy tovaryšstvie a tovaryšstvo ve staré češtině

    Czech Academy of Sciences Publication Activity Database

    Vajdlová, Miloslava

    2015-01-01

    Roč. 98, č. 4 (2015), s. 206-211 ISSN 0027-8203 R&D Projects: GA ČR GAP406/10/1153; GA ČR GAP406/10/1140 Institutional support: RVO:68378092 Keywords : development of language * lexemes tovaryšstvie * tovaryšstvo (Cz) * Old Czech * semantic shift Subject RIV: AI - Linguistics

  20. Génération automatique de lexèmes slaves à partir de leurs racines historiques: une des bases de l'enseignement multilingue des langues slaves de l'ouest (nord et sud

    Directory of Open Access Journals (Sweden)

    Patrice Pognan

    2013-12-01

    Full Text Available Les travaux que nous présentons sont motivés par une série de recherches qui, cumulées les unes aux autres, nous ont menés petit à petit vers une meilleure compréhension du système linguistique slave dans ses dimensions cumulées diachronique et synchronique. Cʼest dans un premier temps lʼexpérience de lʼanalyse automatique de la langue tchèque (textes médicaux, scientifiques et techniques actuels par des techniques heuristiques déterministes basées sur une reconnaissance de formes linguistiques (analyse sans dictionnaire qui fait apparaître la calculabilité du tchèque. Ensuite, lʼenseignement de la grammaire historique du tchèque, essentiellement de son évolution phonologique, a conduit à considérer lʼévolution des langues slaves du Nord- Ouest et les traits qui les distinguent au fur et à mesure les unes des autres.

  1. Model description and evaluation of model performance: DOSDIM model

    International Nuclear Information System (INIS)

    Lewyckyj, N.; Zeevaert, T.

    1996-01-01

    DOSDIM was developed to assess the impact to man from routine and accidental atmospheric releases. It is a compartmental, deterministic, radiological model. For an accidental release, dynamic transfer are used in opposition to a routine release for which equilibrium transfer factors are used. Parameters values were chosen to be conservative. Transfer between compartments are described by first-order differential equations. 2 figs

  2. Urban tree growth modeling

    Science.gov (United States)

    E. Gregory McPherson; Paula J. Peper

    2012-01-01

    This paper describes three long-term tree growth studies conducted to evaluate tree performance because repeated measurements of the same trees produce critical data for growth model calibration and validation. Several empirical and process-based approaches to modeling tree growth are reviewed. Modeling is more advanced in the fields of forestry and...

  3. Classifying variability modeling techniques

    NARCIS (Netherlands)

    Sinnema, Marco; Deelstra, Sybren

    Variability modeling is important for managing variability in software product families, especially during product derivation. In the past few years, several variability modeling techniques have been developed, each using its own concepts to model the variability provided by a product family. The

  4. Climate models and scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Fortelius, C.; Holopainen, E.; Kaurola, J.; Ruosteenoja, K.; Raeisaenen, J. [Helsinki Univ. (Finland). Dept. of Meteorology

    1996-12-31

    In recent years the modelling of interannual climate variability has been studied, the atmospheric energy and water cycles, and climate simulations with the ECHAM3 model. In addition, the climate simulations of several models have been compared with special emphasis in the area of northern Europe

  5. Rock Properties Model

    International Nuclear Information System (INIS)

    Lum, C.

    2004-01-01

    The purpose of this model report is to document the Rock Properties Model version 3.1 with regard to input data, model methods, assumptions, uncertainties and limitations of model results, and qualification status of the model. The report also documents the differences between the current and previous versions and validation of the model. The rock properties model provides mean matrix and lithophysae porosity, and the cross-correlated mean bulk density as direct input to the ''Saturated Zone Flow and Transport Model Abstraction'', MDL-NBS-HS-000021, REV 02 (BSC 2004 [DIRS 170042]). The constraints, caveats, and limitations associated with this model are discussed in Section 6.6 and 8.2. Model validation accomplished by corroboration with data not cited as direct input is discussed in Section 7. The revision of this model report was performed as part of activities being conducted under the ''Technical Work Plan for: The Integrated Site Model, Revision 05'' (BSC 2004 [DIRS 169635]). The purpose of this revision is to bring the report up to current procedural requirements and address the Regulatory Integration Team evaluation comments. The work plan describes the scope, objectives, tasks, methodology, and procedures for this process

  6. THE SLX MODEL

    NARCIS (Netherlands)

    Vega, Solmaria Halleck; Elhorst, J. Paul

    We provide a comprehensive overview of the strengths and weaknesses of different spatial econometric model specifications in terms of spillover effects. Based on this overview, we advocate taking the SLX model as point of departure in case a well-founded theory indicating which model is most

  7. Understandings of 'Modelling'

    DEFF Research Database (Denmark)

    Andresen, Mette

    2007-01-01

    -authentic modelling is also linked with the potentials of exploration of ready-made models as a forerunner for more authentic modelling processes. The discussion includes analysis of an episode of students? work in the classroom, which serves to illustrate how concept formation may be linked to explorations of a non...

  8. Modeling EERE Deployment Programs

    Energy Technology Data Exchange (ETDEWEB)

    Cort, K. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hostick, D. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Belzer, D. B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Livingston, O. V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2007-11-01

    This report compiles information and conclusions gathered as part of the “Modeling EERE Deployment Programs” project. The purpose of the project was to identify and characterize the modeling of deployment programs within the EERE Technology Development (TD) programs, address possible improvements to the modeling process, and note gaps in knowledge in which future research is needed.

  9. Models of Business Internationalisation

    Directory of Open Access Journals (Sweden)

    Jurgita Vabinskaitė

    2011-04-01

    Full Text Available The study deals with the theoretical models of business internationalisation: the “Uppsala” Internationalisation Model, modified “Uppsala” model, the Eclectic Paradigm and analysis of transactional costs, Industrial Network approach, the Advantage Package and the Advantage Cycle.Article in Lithuanian

  10. Modelling: Nature and Use

    DEFF Research Database (Denmark)

    Cameron, Ian; Gani, Rafiqul

    2011-01-01

    Engineering of products and processes is increasingly “model-centric”. Models in their multitudinous forms are ubiquitous, being heavily used for a range of decision making activities across all life cycle phases. This chapter gives an overview of what is a model, the principal activities in the ...

  11. Ecological modeling for all

    OpenAIRE

    Christensen, V.; Pauly, D.

    1996-01-01

    A brief review of the status of the ECOPATH modeling approach and software is presented, with emphasis on the recent release of a Windows version (ECOPATH 3.0), which enables consideration of uncertainties, and sets the stage for simulation modeling using ECOSIM. Modeling of coral reefs is emphasized.

  12. Models selection and fitting

    International Nuclear Information System (INIS)

    Martin Llorente, F.

    1990-01-01

    The models of atmospheric pollutants dispersion are based in mathematic algorithms that describe the transport, diffusion, elimination and chemical reactions of atmospheric contaminants. These models operate with data of contaminants emission and make an estimation of quality air in the area. This model can be applied to several aspects of atmospheric contamination

  13. Loglinear Rasch model tests

    NARCIS (Netherlands)

    Kelderman, Hendrikus

    1984-01-01

    Existing statistical tests for the fit of the Rasch model have been criticized, because they are only sensitive to specific violations of its assumptions. Contingency table methods using loglinear models have been used to test various psychometric models. In this paper, the assumptions of the Rasch

  14. Modeling Epidemic Network Failures

    DEFF Research Database (Denmark)

    Ruepp, Sarah Renée; Fagertun, Anna Manolova

    2013-01-01

    This paper presents the implementation of a failure propagation model for transport networks when multiple failures occur resulting in an epidemic. We model the Susceptible Infected Disabled (SID) epidemic model and validate it by comparing it to analytical solutions. Furthermore, we evaluate...... to evaluate multiple epidemic scenarios in various network types....

  15. The 5C Model

    DEFF Research Database (Denmark)

    Friis, Silje Alberthe Kamille; Gelting, Anne Katrine Gøtzsche

    2014-01-01

    the approaches and reach a new level of conscious action when designing? Informed by theories of design thinking, knowledge production, and learning, we have developed a model, the 5C model, accompanied by 62 method cards. Examples of how the model has been applied in an educational setting are provided...

  16. The nontopological soliton model

    International Nuclear Information System (INIS)

    Wilets, L.

    1988-01-01

    The nontopological soliton model introduced by Friedberg and Lee, and variations of it, provide a method for modeling QCD which can effectively include the dynamics of hadronic collisions as well as spectra. Absolute color confinement is effected by the assumed dielectric properties of the medium. A recently proposed version of the model is chirally invariant. 32 refs., 5 figs., 1 tab

  17. The cloudy bag model

    International Nuclear Information System (INIS)

    Thomas, A.W.

    1981-01-01

    Recent developments in the bag model, in which the constraints of chiral symmetry are explicitly included are reviewed. The model leads to a new understanding of the Δ-resonance. The connection of the theory with current algebra is clarified and implications of the model for the structure of the nucleon are discussed

  18. Flexible survival regression modelling

    DEFF Research Database (Denmark)

    Cortese, Giuliana; Scheike, Thomas H; Martinussen, Torben

    2009-01-01

    Regression analysis of survival data, and more generally event history data, is typically based on Cox's regression model. We here review some recent methodology, focusing on the limitations of Cox's regression model. The key limitation is that the model is not well suited to represent time-varyi...

  19. Automated Simulation Model Generation

    NARCIS (Netherlands)

    Huang, Y.

    2013-01-01

    One of today's challenges in the field of modeling and simulation is to model increasingly larger and more complex systems. Complex models take long to develop and incur high costs. With the advances in data collection technologies and more popular use of computer-aided systems, more data has become

  20. Genome-Scale Models

    DEFF Research Database (Denmark)

    Bergdahl, Basti; Sonnenschein, Nikolaus; Machado, Daniel

    2016-01-01

    An introduction to genome-scale models, how to build and use them, will be given in this chapter. Genome-scale models have become an important part of systems biology and metabolic engineering, and are increasingly used in research, both in academica and in industry, both for modeling chemical pr...

  1. Models and Indicators.

    Science.gov (United States)

    Land, Kenneth C.

    2001-01-01

    Examines the definition, construction, and interpretation of social indicators. Shows how standard classes of formalisms used to construct models in contemporary sociology are derived from the general theory of models. Reviews recent model building and evaluation related to active life expectancy among the elderly, fertility rates, and indicators…

  2. Intersection of Feature Models

    NARCIS (Netherlands)

    van den Broek, P.M.

    In this paper, we present an algorithm for the construction of the intersection of two feature models. The feature models are allowed to have "requires" and "excludes" constraints, and should be parent-compatible. The algorithm is applied to the problem of combining feature models from stakeholders

  3. Merging Feature Models

    NARCIS (Netherlands)

    van den Broek, P.M.; Galvao, I.; Noppen, J.A.R.

    2010-01-01

    In this paper, we consider the problem of merging feature models which consist of trees with "requires" and "excludes" constraints. For any two such feature models which are parent-compatible, their merge is defined to be the smallest parent-compatible feature model which has all products of the

  4. Modeling Natural Selection

    Science.gov (United States)

    Bogiages, Christopher A.; Lotter, Christine

    2011-01-01

    In their research, scientists generate, test, and modify scientific models. These models can be shared with others and demonstrate a scientist's understanding of how the natural world works. Similarly, students can generate and modify models to gain a better understanding of the content, process, and nature of science (Kenyon, Schwarz, and Hug…

  5. Model Breaking Points Conceptualized

    Science.gov (United States)

    Vig, Rozy; Murray, Eileen; Star, Jon R.

    2014-01-01

    Current curriculum initiatives (e.g., National Governors Association Center for Best Practices and Council of Chief State School Officers 2010) advocate that models be used in the mathematics classroom. However, despite their apparent promise, there comes a point when models break, a point in the mathematical problem space where the model cannot,…

  6. Scalability of human models

    NARCIS (Netherlands)

    Rodarius, C.; Rooij, L. van; Lange, R. de

    2007-01-01

    The objective of this work was to create a scalable human occupant model that allows adaptation of human models with respect to size, weight and several mechanical parameters. Therefore, for the first time two scalable facet human models were developed in MADYMO. First, a scalable human male was

  7. Dynamic term structure models

    DEFF Research Database (Denmark)

    Andreasen, Martin Møller; Meldrum, Andrew

    pricing factors using the sequential regression approach. Our findings suggest that the two models largely provide the same in-sample fit, but loadings from ordinary and risk-adjusted Campbell-Shiller regressions are generally best matched by the shadow rate models. We also find that the shadow rate...... models perform better than the QTSMs when forecasting bond yields out of sample....

  8. Modeling agriculture in the Community Land Model

    Directory of Open Access Journals (Sweden)

    B. Drewniak

    2013-04-01

    Full Text Available The potential impact of climate change on agriculture is uncertain. In addition, agriculture could influence above- and below-ground carbon storage. Development of models that represent agriculture is necessary to address these impacts. We have developed an approach to integrate agriculture representations for three crop types – maize, soybean, and spring wheat – into the coupled carbon–nitrogen version of the Community Land Model (CLM, to help address these questions. Here we present the new model, CLM-Crop, validated against observations from two AmeriFlux sites in the United States, planted with maize and soybean. Seasonal carbon fluxes compared well with field measurements for soybean, but not as well for maize. CLM-Crop yields were comparable with observations in countries such as the United States, Argentina, and China, although the generality of the crop model and its lack of technology and irrigation made direct comparison difficult. CLM-Crop was compared against the standard CLM3.5, which simulates crops as grass. The comparison showed improvement in gross primary productivity in regions where crops are the dominant vegetation cover. Crop yields and productivity were negatively correlated with temperature and positively correlated with precipitation, in agreement with other modeling studies. In case studies with the new crop model looking at impacts of residue management and planting date on crop yield, we found that increased residue returned to the litter pool increased crop yield, while reduced residue returns resulted in yield decreases. Using climate controls to signal planting date caused different responses in different crops. Maize and soybean had opposite reactions: when low temperature threshold resulted in early planting, maize responded with a loss of yield, but soybean yields increased. Our improvements in CLM demonstrate a new capability in the model – simulating agriculture in a realistic way, complete with

  9. Modeling agriculture in the Community Land Model

    Science.gov (United States)

    Drewniak, B.; Song, J.; Prell, J.; Kotamarthi, V. R.; Jacob, R.

    2013-04-01

    The potential impact of climate change on agriculture is uncertain. In addition, agriculture could influence above- and below-ground carbon storage. Development of models that represent agriculture is necessary to address these impacts. We have developed an approach to integrate agriculture representations for three crop types - maize, soybean, and spring wheat - into the coupled carbon-nitrogen version of the Community Land Model (CLM), to help address these questions. Here we present the new model, CLM-Crop, validated against observations from two AmeriFlux sites in the United States, planted with maize and soybean. Seasonal carbon fluxes compared well with field measurements for soybean, but not as well for maize. CLM-Crop yields were comparable with observations in countries such as the United States, Argentina, and China, although the generality of the crop model and its lack of technology and irrigation made direct comparison difficult. CLM-Crop was compared against the standard CLM3.5, which simulates crops as grass. The comparison showed improvement in gross primary productivity in regions where crops are the dominant vegetation cover. Crop yields and productivity were negatively correlated with temperature and positively correlated with precipitation, in agreement with other modeling studies. In case studies with the new crop model looking at impacts of residue management and planting date on crop yield, we found that increased residue returned to the litter pool increased crop yield, while reduced residue returns resulted in yield decreases. Using climate controls to signal planting date caused different responses in different crops. Maize and soybean had opposite reactions: when low temperature threshold resulted in early planting, maize responded with a loss of yield, but soybean yields increased. Our improvements in CLM demonstrate a new capability in the model - simulating agriculture in a realistic way, complete with fertilizer and residue management

  10. Transgenesis for pig models.

    Science.gov (United States)

    Yum, Soo-Young; Yoon, Ki-Young; Lee, Choong-Il; Lee, Byeong-Chun; Jang, Goo

    2016-09-30

    Animal models, particularly pigs, have come to play an important role in translational biomedical research. There have been many pig models with genetically modifications via somatic cell nuclear transfer (SCNT). However, because most transgenic pigs have been produced by random integration to date, the necessity for more exact gene-mutated models using recombinase based conditional gene expression like mice has been raised. Currently, advanced genome-editing technologies enable us to generate specific gene-deleted and -inserted pig models. In the future, the development of pig models with gene editing technologies could be a valuable resource for biomedical research.

  11. Mathematical modelling techniques

    CERN Document Server

    Aris, Rutherford

    1995-01-01

    ""Engaging, elegantly written."" - Applied Mathematical ModellingMathematical modelling is a highly useful methodology designed to enable mathematicians, physicists and other scientists to formulate equations from a given nonmathematical situation. In this elegantly written volume, a distinguished theoretical chemist and engineer sets down helpful rules not only for setting up models but also for solving the mathematical problems they pose and for evaluating models.The author begins with a discussion of the term ""model,"" followed by clearly presented examples of the different types of mode

  12. SAS "New" Business Model

    OpenAIRE

    Sörhammar, David; Bengtson, Anna

    2006-01-01

    In September 2005 SAS introduced a new business model. Where did the model come from and what influenced it? This paper’s focus is on the making of the model where we study the making of a business model as a dynamic process through time. In concrete terms, traces of today’s model can be found and examined from the SAS group’s embryonic attempts starting in 1946, through the financially good years during the 1980s, to the market re-regulation in contemporary time. During these years several c...

  13. The interacting boson model

    International Nuclear Information System (INIS)

    Iachello, F.; Arima, A.

    1987-01-01

    The book gives an account of some of the properties of the interacting boson model. The model was introduced in 1974 to describe in a unified way the collective properties of nuclei. The book presents the mathematical techniques used to analyse the structure of the model. The mathematical framework of the model is discussed in detail. The book also contains all the formulae that have been developed throughout the years to account for collective properties of nuclei. These formulae can be used by experimentalists to compare their data with the predictions of the model. (U.K.)

  14. CRAC2 model description

    International Nuclear Information System (INIS)

    Ritchie, L.T.; Alpert, D.J.; Burke, R.P.; Johnson, J.D.; Ostmeyer, R.M.; Aldrich, D.C.; Blond, R.M.

    1984-03-01

    The CRAC2 computer code is a revised version of CRAC (Calculation of Reactor Accident Consequences) which was developed for the Reactor Safety Study. This document provides an overview of the CRAC2 code and a description of each of the models used. Significant improvements incorporated into CRAC2 include an improved weather sequence sampling technique, a new evacuation model, and new output capabilities. In addition, refinements have been made to the atmospheric transport and deposition model. Details of the modeling differences between CRAC2 and CRAC are emphasized in the model descriptions

  15. Model-independent differences

    DEFF Research Database (Denmark)

    Könemann, Patrick

    2009-01-01

    Computing differences (diffs) and merging different versions is well-known for text files, but for models it is a very young field - especially patches for models are still matter of research. Text-based and model-based diffs have different starting points because the semantics of their structure...... is fundamentally different. This paper reports on our ongoing work on model-independent diffs, i.e. a diff that does not directly refer to the models it was created from. Based on that, we present an idea of how the diff could be generalized, e.g. many atomic diffs are merged to a new, generalized diff. One use...

  16. Models of human operators

    International Nuclear Information System (INIS)

    Knee, H.E.; Schryver, J.C.

    1991-01-01

    Models of human behavior and cognition (HB and C) are necessary for understanding the total response of complex systems. Many such models have come available over the past thirty years for various applications. Unfortunately, many potential model users remain skeptical about their practicality, acceptability, and usefulness. Such hesitancy stems in part to disbelief in the ability to model complex cognitive processes, and a belief that relevant human behavior can be adequately accounted for through the use of commonsense heuristics. This paper will highlight several models of HB and C and identify existing and potential applications in attempt to dispel such notions. (author)

  17. Patterns of data modeling

    CERN Document Server

    Blaha, Michael

    2010-01-01

    Best-selling author and database expert with more than 25 years of experience modeling application and enterprise data, Dr. Michael Blaha provides tried and tested data model patterns, to help readers avoid common modeling mistakes and unnecessary frustration on their way to building effective data models. Unlike the typical methodology book, "Patterns of Data Modeling" provides advanced techniques for those who have mastered the basics. Recognizing that database representation sets the path for software, determines its flexibility, affects its quality, and influences whether it succ

  18. UZ Colloid Transport Model

    International Nuclear Information System (INIS)

    McGraw, M.

    2000-01-01

    The UZ Colloid Transport model development plan states that the objective of this Analysis/Model Report (AMR) is to document the development of a model for simulating unsaturated colloid transport. This objective includes the following: (1) use of a process level model to evaluate the potential mechanisms for colloid transport at Yucca Mountain; (2) Provide ranges of parameters for significant colloid transport processes to Performance Assessment (PA) for the unsaturated zone (UZ); (3) Provide a basis for development of an abstracted model for use in PA calculations

  19. A Model for Information

    Directory of Open Access Journals (Sweden)

    Paul Walton

    2014-09-01

    Full Text Available This paper uses an approach drawn from the ideas of computer systems modelling to produce a model for information itself. The model integrates evolutionary, static and dynamic views of information and highlights the relationship between symbolic content and the physical world. The model includes what information technology practitioners call “non-functional” attributes, which, for information, include information quality and information friction. The concepts developed in the model enable a richer understanding of Floridi’s questions “what is information?” and “the informational circle: how can information be assessed?” (which he numbers P1 and P12.

  20. Complex matrix model duality

    Energy Technology Data Exchange (ETDEWEB)

    Brown, T.W.

    2010-11-15

    The same complex matrix model calculates both tachyon scattering for the c=1 non-critical string at the self-dual radius and certain correlation functions of half-BPS operators in N=4 super- Yang-Mills. It is dual to another complex matrix model where the couplings of the first model are encoded in the Kontsevich-like variables of the second. The duality between the theories is mirrored by the duality of their Feynman diagrams. Analogously to the Hermitian Kontsevich- Penner model, the correlation functions of the second model can be written as sums over discrete points in subspaces of the moduli space of punctured Riemann surfaces. (orig.)

  1. Graphical Models with R

    DEFF Research Database (Denmark)

    Højsgaard, Søren; Edwards, David; Lauritzen, Steffen L.

    of these software developments have taken place within the R community, either in the form of new packages or by providing an R ingerface to existing software. This book attempts to give the reader a gentle introduction to graphical modeling using R and the main features of some of these packages. In addition......, the book provides examples of how more advanced aspects of graphical modeling can be represented and handled within R. Topics covered in the seven chapters include graphical models for contingency tables, Gaussian and mixed graphical models, Bayesian networks and modeling high dimensional data...

  2. Mechanics of materials model

    Science.gov (United States)

    Meister, Jeffrey P.

    1987-01-01

    The Mechanics of Materials Model (MOMM) is a three-dimensional inelastic structural analysis code for use as an early design stage tool for hot section components. MOMM is a stiffness method finite element code that uses a network of beams to characterize component behavior. The MOMM contains three material models to account for inelastic material behavior. These include the simplified material model, which assumes a bilinear stress-strain response; the state-of-the-art model, which utilizes the classical elastic-plastic-creep strain decomposition; and Walker's viscoplastic model, which accounts for the interaction between creep and plasticity that occurs under cyclic loading conditions.

  3. Process modeling style

    CERN Document Server

    Long, John

    2014-01-01

    Process Modeling Style focuses on other aspects of process modeling beyond notation that are very important to practitioners. Many people who model processes focus on the specific notation used to create their drawings. While that is important, there are many other aspects to modeling, such as naming, creating identifiers, descriptions, interfaces, patterns, and creating useful process documentation. Experience author John Long focuses on those non-notational aspects of modeling, which practitioners will find invaluable. Gives solid advice for creating roles, work produ

  4. Computer Based Modelling and Simulation

    Indian Academy of Sciences (India)

    leaving students. It is a probabilistic model. In the next part of this article, two more models - 'input/output model' used for production systems or economic studies and a. 'discrete event simulation model' are introduced. Aircraft Performance Model.

  5. Making ecological models adequate

    Science.gov (United States)

    Getz, Wayne M.; Marshall, Charles R.; Carlson, Colin J.; Giuggioli, Luca; Ryan, Sadie J.; Romañach, Stephanie; Boettiger, Carl; Chamberlain, Samuel D.; Larsen, Laurel; D'Odorico, Paolo; O'Sullivan, David

    2018-01-01

    Critical evaluation of the adequacy of ecological models is urgently needed to enhance their utility in developing theory and enabling environmental managers and policymakers to make informed decisions. Poorly supported management can have detrimental, costly or irreversible impacts on the environment and society. Here, we examine common issues in ecological modelling and suggest criteria for improving modelling frameworks. An appropriate level of process description is crucial to constructing the best possible model, given the available data and understanding of ecological structures. Model details unsupported by data typically lead to over parameterisation and poor model performance. Conversely, a lack of mechanistic details may limit a model's ability to predict ecological systems’ responses to management. Ecological studies that employ models should follow a set of model adequacy assessment protocols that include: asking a series of critical questions regarding state and control variable selection, the determinacy of data, and the sensitivity and validity of analyses. We also need to improve model elaboration, refinement and coarse graining procedures to better understand the relevancy and adequacy of our models and the role they play in advancing theory, improving hind and forecasting, and enabling problem solving and management.

  6. Modelling Farm Animal Welfare

    Science.gov (United States)

    Collins, Lisa M.; Part, Chérie E.

    2013-01-01

    Simple Summary In this review paper we discuss the different modeling techniques that have been used in animal welfare research to date. We look at what questions they have been used to answer, the advantages and pitfalls of the methods, and how future research can best use these approaches to answer some of the most important upcoming questions in farm animal welfare. Abstract The use of models in the life sciences has greatly expanded in scope and advanced in technique in recent decades. However, the range, type and complexity of models used in farm animal welfare is comparatively poor, despite the great scope for use of modeling in this field of research. In this paper, we review the different modeling approaches used in farm animal welfare science to date, discussing the types of questions they have been used to answer, the merits and problems associated with the method, and possible future applications of each technique. We find that the most frequently published types of model used in farm animal welfare are conceptual and assessment models; two types of model that are frequently (though not exclusively) based on expert opinion. Simulation, optimization, scenario, and systems modeling approaches are rarer in animal welfare, despite being commonly used in other related fields. Finally, common issues such as a lack of quantitative data to parameterize models, and model selection and validation are discussed throughout the review, with possible solutions and alternative approaches suggested. PMID:26487411

  7. Calibrated Properties Model

    Energy Technology Data Exchange (ETDEWEB)

    T. Ghezzehej

    2004-10-04

    The purpose of this model report is to document the calibrated properties model that provides calibrated property sets for unsaturated zone (UZ) flow and transport process models (UZ models). The calibration of the property sets is performed through inverse modeling. This work followed, and was planned in, ''Technical Work Plan (TWP) for: Unsaturated Zone Flow Analysis and Model Report Integration'' (BSC 2004 [DIRS 169654], Sections 1.2.6 and 2.1.1.6). Direct inputs to this model report were derived from the following upstream analysis and model reports: ''Analysis of Hydrologic Properties Data'' (BSC 2004 [DIRS 170038]); ''Development of Numerical Grids for UZ Flow and Transport Modeling'' (BSC 2004 [DIRS 169855]); ''Simulation of Net Infiltration for Present-Day and Potential Future Climates'' (BSC 2004 [DIRS 170007]); ''Geologic Framework Model'' (GFM2000) (BSC 2004 [DIRS 170029]). Additionally, this model report incorporates errata of the previous version and closure of the Key Technical Issue agreement TSPAI 3.26 (Section 6.2.2 and Appendix B), and it is revised for improved transparency.

  8. Programming Models in HPC

    Energy Technology Data Exchange (ETDEWEB)

    Shipman, Galen M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-06-13

    These are the slides for a presentation on programming models in HPC, at the Los Alamos National Laboratory's Parallel Computing Summer School. The following topics are covered: Flynn's Taxonomy of computer architectures; single instruction single data; single instruction multiple data; multiple instruction multiple data; address space organization; definition of Trinity (Intel Xeon-Phi is a MIMD architecture); single program multiple data; multiple program multiple data; ExMatEx workflow overview; definition of a programming model, programming languages, runtime systems; programming model and environments; MPI (Message Passing Interface); OpenMP; Kokkos (Performance Portable Thread-Parallel Programming Model); Kokkos abstractions, patterns, policies, and spaces; RAJA, a systematic approach to node-level portability and tuning; overview of the Legion Programming Model; mapping tasks and data to hardware resources; interoperability: supporting task-level models; Legion S3D execution and performance details; workflow, integration of external resources into the programming model.

  9. CREDIT RISK. DETERMINATION MODELS

    Directory of Open Access Journals (Sweden)

    MIHAELA GRUIESCU

    2012-01-01

    Full Text Available The internationalization of financial flows and banking and the rapid development of markets have changed the financial sector, causing him to respond with force and imagination. Under these conditions, the concerns of financial and banking institutions, rating institutions are increasingly turning to find the best solutions to hedge risks and maximize profits. This paper aims to present a number of advantages, but also limits the Merton model, the first structural model for modeling credit risk. Also, some are extensions of the model, some empirical research and performance known, others such as state-dependent models (SDM, which together with the liquidation process models (LPM, are two recent efforts in the structural models, show different phenomena in real life.

  10. Modelling of wastewater systems

    DEFF Research Database (Denmark)

    Bechmann, Henrik

    Oxygen Demand) flux and SS flux in the inlet to the WWTP. COD is measured by means of a UV absorption sensor while SS is measured by a turbidity sensor. These models include a description of the deposit of COD and SS amounts, respectively, in the sewer system, and the models can thus be used to quantify......In this thesis, models of pollution fluxes in the inlet to 2 Danish wastewater treatment plants (WWTPs) as well as of suspended solids (SS) concentrations in the aeration tanks of an alternating WWTP and in the effluent from the aeration tanks are developed. The latter model is furthermore used...... to analyze and quantify the effect of the Aeration Tank Settling (ATS) operating mode, which is used during rain events. Furthermore, the model is used to propose a control algorithm for the phase lengths during ATS operation. The models are mainly formulated as state space model in continuous time...

  11. Foam process models.

    Energy Technology Data Exchange (ETDEWEB)

    Moffat, Harry K.; Noble, David R.; Baer, Thomas A. (Procter & Gamble Co., West Chester, OH); Adolf, Douglas Brian; Rao, Rekha Ranjana; Mondy, Lisa Ann

    2008-09-01

    In this report, we summarize our work on developing a production level foam processing computational model suitable for predicting the self-expansion of foam in complex geometries. The model is based on a finite element representation of the equations of motion, with the movement of the free surface represented using the level set method, and has been implemented in SIERRA/ARIA. An empirically based time- and temperature-dependent density model is used to encapsulate the complex physics of foam nucleation and growth in a numerically tractable model. The change in density with time is at the heart of the foam self-expansion as it creates the motion of the foam. This continuum-level model uses an homogenized description of foam, which does not include the gas explicitly. Results from the model are compared to temperature-instrumented flow visualization experiments giving the location of the foam front as a function of time for our EFAR model system.

  12. Hydrological land surface modelling

    DEFF Research Database (Denmark)

    Ridler, Marc-Etienne Francois

    and disaster management. The objective of this study is to develop and investigate methods to reduce hydrological model uncertainty by using supplementary data sources. The data is used either for model calibration or for model updating using data assimilation. Satellite estimates of soil moisture and surface......Recent advances in integrated hydrological and soil-vegetation-atmosphere transfer (SVAT) modelling have led to improved water resource management practices, greater crop production, and better flood forecasting systems. However, uncertainty is inherent in all numerical models ultimately leading...... hydrological and tested by assimilating synthetic hydraulic head observations in a catchment in Denmark. Assimilation led to a substantial reduction of model prediction error, and better model forecasts. Also, a new assimilation scheme is developed to downscale and bias-correct coarse satellite derived soil...

  13. Hydrological land surface modelling

    DEFF Research Database (Denmark)

    Ridler, Marc-Etienne Francois

    Recent advances in integrated hydrological and soil-vegetation-atmosphere transfer (SVAT) modelling have led to improved water resource management practices, greater crop production, and better flood forecasting systems. However, uncertainty is inherent in all numerical models ultimately leading...... and disaster management. The objective of this study is to develop and investigate methods to reduce hydrological model uncertainty by using supplementary data sources. The data is used either for model calibration or for model updating using data assimilation. Satellite estimates of soil moisture and surface...... hydrological and tested by assimilating synthetic hydraulic head observations in a catchment in Denmark. Assimilation led to a substantial reduction of model prediction error, and better model forecasts. Also, a new assimilation scheme is developed to downscale and bias-correct coarse satellite derived soil...

  14. WWTP Process Tank Modelling

    DEFF Research Database (Denmark)

    Laursen, Jesper

    solution of the Navier-Stokes equations in a multiphase scheme. After a general introduction to the activated sludge tank as a system, the activated sludge tank model is gradually setup in separate stages. The individual sub-processes that are often occurring in activated sludge tanks are initially......-process models, the last part of the thesis, where the integrated process tank model is tested on three examples of activated sludge systems, is initiated. The three case studies are introduced with an increasing degree of model complexity. All three cases are take basis in Danish municipal wastewater treatment...... plants. The first case study involves the modeling of an activated sludge tank undergoing a special controlling strategy with the intention minimizing the sludge loading on the subsequent secondary settlers during storm events. The applied model is a two-phase model, where the sedimentation of sludge...

  15. Aware design models

    DEFF Research Database (Denmark)

    Tamke, Martin

    2015-01-01

    and informed feedback. Introducing the term "Aware models", the paper investigates how computational models become an enabler for a better informed architectural design practice, through the embedding of knowledge about constraints, behaviour and processes of formation and making into generative design models......Appearing almost alive, a novel set of computational design models can become an active counterpart for architects in the design process. The ability to loop, sense and query and the integration of near real-time simulation provide these models with a depth and agility that allows for instant....... The inspection of several computational design projects in architectural research highlights three different types of awareness a model can possess and devises strategies to establish and finally design with aware models. This design practice is collaborative in nature and characterized by a bidirectional flow...

  16. MODERN MEDIA EDUCATION MODELS

    Directory of Open Access Journals (Sweden)

    Alexander Fedorov

    2011-03-01

    Full Text Available The author supposed that media education models can be divided into the following groups:- educational-information models (the study of the theory, history, language of media culture, etc., based on the cultural, aesthetic, semiotic, socio-cultural theories of media education;- educational-ethical models (the study of moral, religions, philosophical problems relying on the ethic, religious, ideological, ecological, protectionist theories of media education;- pragmatic models (practical media technology training, based on the uses and gratifications and ‘practical’ theories of media education;- aesthetical models (aimed above all at the development of the artistic taste and enriching the skills of analysis of the best media culture examples. Relies on the aesthetical (art and cultural studies theory; - socio-cultural models (socio-cultural development of a creative personality as to the perception, imagination, visual memory, interpretation analysis, autonomic critical thinking, relying on the cultural studies, semiotic, ethic models of media education.

  17. Untangling RFID Privacy Models

    Directory of Open Access Journals (Sweden)

    Iwen Coisel

    2013-01-01

    Full Text Available The rise of wireless applications based on RFID has brought up major concerns on privacy. Indeed nowadays, when such an application is deployed, informed customers yearn for guarantees that their privacy will not be threatened. One formal way to perform this task is to assess the privacy level of the RFID application with a model. However, if the chosen model does not reflect the assumptions and requirements of the analyzed application, it may misevaluate its privacy level. Therefore, selecting the most appropriate model among all the existing ones is not an easy task. This paper investigates the eight most well-known RFID privacy models and thoroughly examines their advantages and drawbacks in three steps. Firstly, five RFID authentication protocols are analyzed with these models. This discloses a main worry: although these protocols intuitively ensure different privacy levels, no model is able to accurately distinguish them. Secondly, these models are grouped according to their features (e.g., tag corruption ability. This classification reveals the most appropriate candidate model(s to be used for a privacy analysis when one of these features is especially required. Furthermore, it points out that none of the models are comprehensive. Hence, some combinations of features may not match any model. Finally, the privacy properties of the eight models are compared in order to provide an overall view of their relations. This part highlights that no model globally outclasses the other ones. Considering the required properties of an application, the thorough study provided in this paper aims to assist system designers to choose the best suited model.

  18. Constitutive models in LAME.

    Energy Technology Data Exchange (ETDEWEB)

    Hammerand, Daniel Carl; Scherzinger, William Mark

    2007-09-01

    The Library of Advanced Materials for Engineering (LAME) provides a common repository for constitutive models that can be used in computational solid mechanics codes. A number of models including both hypoelastic (rate) and hyperelastic (total strain) constitutive forms have been implemented in LAME. The structure and testing of LAME is described in Scherzinger and Hammerand ([3] and [4]). The purpose of the present report is to describe the material models which have already been implemented into LAME. The descriptions are designed to give useful information to both analysts and code developers. Thus far, 33 non-ITAR/non-CRADA protected material models have been incorporated. These include everything from the simple isotropic linear elastic models to a number of elastic-plastic models for metals to models for honeycomb, foams, potting epoxies and rubber. A complete description of each model is outside the scope of the current report. Rather, the aim here is to delineate the properties, state variables, functions, and methods for each model. However, a brief description of some of the constitutive details is provided for a number of the material models. Where appropriate, the SAND reports available for each model have been cited. Many models have state variable aliases for some or all of their state variables. These alias names can be used for outputting desired quantities. The state variable aliases available for results output have been listed in this report. However, not all models use these aliases. For those models, no state variable names are listed. Nevertheless, the number of state variables employed by each model is always given. Currently, there are four possible functions for a material model. This report lists which of these four methods are employed in each material model. As far as analysts are concerned, this information is included only for the awareness purposes. The analyst can take confidence in the fact that model has been properly implemented

  19. Systemic resilience model

    International Nuclear Information System (INIS)

    Lundberg, Jonas; Johansson, Björn JE

    2015-01-01

    It has been realized that resilience as a concept involves several contradictory definitions, both for instance resilience as agile adjustment and as robust resistance to situations. Our analysis of resilience concepts and models suggest that beyond simplistic definitions, it is possible to draw up a systemic resilience model (SyRes) that maintains these opposing characteristics without contradiction. We outline six functions in a systemic model, drawing primarily on resilience engineering, and disaster response: anticipation, monitoring, response, recovery, learning, and self-monitoring. The model consists of four areas: Event-based constraints, Functional Dependencies, Adaptive Capacity and Strategy. The paper describes dependencies between constraints, functions and strategies. We argue that models such as SyRes should be useful both for envisioning new resilience methods and metrics, as well as for engineering and evaluating resilient systems. - Highlights: • The SyRes model resolves contradictions between previous resilience definitions. • SyRes is a core model for envisioning and evaluating resilience metrics and models. • SyRes describes six functions in a systemic model. • They are anticipation, monitoring, response, recovery, learning, self-monitoring. • The model describes dependencies between constraints, functions and strategies

  20. Modeling Quantum Well Lasers

    Directory of Open Access Journals (Sweden)

    Dan Alexandru Anghel

    2012-01-01

    Full Text Available In semiconductor laser modeling, a good mathematical model gives near-reality results. Three methods of modeling solutions from the rate equations are presented and analyzed. A method based on the rate equations modeled in Simulink to describe quantum well lasers was presented. For different signal types like step function, saw tooth and sinus used as input, a good response of the used equations is obtained. Circuit model resulting from one of the rate equations models is presented and simulated in SPICE. Results show a good modeling behavior. Numerical simulation in MathCad gives satisfactory results for the study of the transitory and dynamic operation at small level of the injection current. The obtained numerical results show the specific limits of each model, according to theoretical analysis. Based on these results, software can be built that integrates circuit simulation and other modeling methods for quantum well lasers to have a tool that model and analysis these devices from all points of view.

  1. Geochemical modeling: a review

    International Nuclear Information System (INIS)

    Jenne, E.A.

    1981-06-01

    Two general families of geochemical models presently exist. The ion speciation-solubility group of geochemical models contain submodels to first calculate a distribution of aqueous species and to secondly test the hypothesis that the water is near equilibrium with particular solid phases. These models may or may not calculate the adsorption of dissolved constituents and simulate the dissolution and precipitation (mass transfer) of solid phases. Another family of geochemical models, the reaction path models, simulates the stepwise precipitation of solid phases as a result of reacting specified amounts of water and rock. Reaction path models first perform an aqueous speciation of the dissolved constituents of the water, test solubility hypotheses, then perform the reaction path modeling. Certain improvements in the present versions of these models would enhance their value and usefulness to applications in nuclear-waste isolation, etc. Mass-transfer calculations of limited extent are certainly within the capabilities of state-of-the-art models. However, the reaction path models require an expansion of their thermodynamic data bases and systematic validation before they are generally accepted

  2. The Tanaka model

    International Nuclear Information System (INIS)

    Tanaka, G.

    1998-01-01

    The data presented here includes male and female models for Asian populations in the age groups: Newborn, 1 year, 5 years, 10 years, 15 years and adult. The model for adult male was presented at the 3rd Research Coordination Meeting held in Tianjin, October 1993. At that time, the CRP participants requested Dr. Tanaka to continue development of a female model. The adult female model was developed together with models for five younger age groups. It is intended to provide useful data for radiation protection, and has been submitted to ICRP for use in developing revised models for internal dosimetry. The model is based on normal organ masses as well as physical measurements obtained primarily from Chinese, Indian and Japanese populations. These are believed to be the most extensive data sets available. The data presented here also takes into account the variations found in the data reported by other CRP participants. It should be stressed that the model is, at the same time, based on the approach used by the ICRP Reference Man Task Group in development of their Reference Man. As noted above, the adult male model was presented at the RCM Meeting in Tianjin and approved by the participants as ''Tanaka Model'' that would be convenient for use in internal dosimetry studies for subjects from Asian populations. It is also the essential part of a publication which is a revised edition of the previous work

  3. Modeling environmental policy

    International Nuclear Information System (INIS)

    Martin, W.E.; McDonald, L.A.

    1997-01-01

    The eight book chapters demonstrate the link between the physical models of the environment and the policy analysis in support of policy making. Each chapter addresses an environmental policy issue using a quantitative modeling approach. The volume addresses three general areas of environmental policy - non-point source pollution in the agricultural sector, pollution generated in the extractive industries, and transboundary pollutants from burning fossil fuels. The book concludes by discussing the modeling efforts and the use of mathematical models in general. Chapters are entitled: modeling environmental policy: an introduction; modeling nonpoint source pollution in an integrated system (agri-ecological); modeling environmental and trade policy linkages: the case of EU and US agriculture; modeling ecosystem constraints in the Clean Water Act: a case study in Clearwater National Forest (subject to discharge from metal mining waste); costs and benefits of coke oven emission controls; modeling equilibria and risk under global environmental constraints (discussing energy and environmental interrelations); relative contribution of the enhanced greenhouse effect on the coastal changes in Louisiana; and the use of mathematical models in policy evaluations: comments. The paper on coke area emission controls has been abstracted separately for the IEA Coal Research CD-ROM

  4. Drought modeling - A review

    Science.gov (United States)

    Mishra, Ashok K.; Singh, Vijay P.

    2011-06-01

    SummaryIn recent years droughts have been occurring frequently, and their impacts are being aggravated by the rise in water demand and the variability in hydro-meteorological variables due to climate change. As a result, drought hydrology has been receiving much attention. A variety of concepts have been applied to modeling droughts, ranging from simplistic approaches to more complex models. It is important to understand different modeling approaches as well as their advantages and limitations. This paper, supplementing the previous paper ( Mishra and Singh, 2010) where different concepts of droughts were highlighted, reviews different methodologies used for drought modeling, which include drought forecasting, probability based modeling, spatio-temporal analysis, use of Global Climate Models (GCMs) for drought scenarios, land data assimilation systems for drought modeling, and drought planning. It is found that there have been significant improvements in modeling droughts over the past three decades. Hybrid models, incorporating large scale climate indices, seem to be promising for long lead-time drought forecasting. Further research is needed to understand the spatio-temporal complexity of droughts under climate change due to changes in spatio-temporal variability of precipitation. Applications of copula based models for multivariate drought characterization seem to be promising for better drought characterization. Research on decision support systems should be advanced for issuing warnings, assessing risk, and taking precautionary measures, and the effective ways for the flow of information from decision makers to users need to be developed. Finally, some remarks are made regarding the future outlook for drought research.

  5. Models as Relational Categories

    Science.gov (United States)

    Kokkonen, Tommi

    2017-11-01

    Model-based learning (MBL) has an established position within science education. It has been found to enhance conceptual understanding and provide a way for engaging students in authentic scientific activity. Despite ample research, few studies have examined the cognitive processes regarding learning scientific concepts within MBL. On the other hand, recent research within cognitive science has examined the learning of so-called relational categories. Relational categories are categories whose membership is determined on the basis of the common relational structure. In this theoretical paper, I argue that viewing models as relational categories provides a well-motivated cognitive basis for MBL. I discuss the different roles of models and modeling within MBL (using ready-made models, constructive modeling, and generative modeling) and discern the related cognitive aspects brought forward by the reinterpretation of models as relational categories. I will argue that relational knowledge is vital in learning novel models and in the transfer of learning. Moreover, relational knowledge underlies the coherent, hierarchical knowledge of experts. Lastly, I will examine how the format of external representations may affect the learning of models and the relevant relations. The nature of the learning mechanisms underlying students' mental representations of models is an interesting open question to be examined. Furthermore, the ways in which the expert-like knowledge develops and how to best support it is in need of more research. The discussion and conceptualization of models as relational categories allows discerning students' mental representations of models in terms of evolving relational structures in greater detail than previously done.

  6. The Protein Model Portal.

    Science.gov (United States)

    Arnold, Konstantin; Kiefer, Florian; Kopp, Jürgen; Battey, James N D; Podvinec, Michael; Westbrook, John D; Berman, Helen M; Bordoli, Lorenza; Schwede, Torsten

    2009-03-01

    Structural Genomics has been successful in determining the structures of many unique proteins in a high throughput manner. Still, the number of known protein sequences is much larger than the number of experimentally solved protein structures. Homology (or comparative) modeling methods make use of experimental protein structures to build models for evolutionary related proteins. Thereby, experimental structure determination efforts and homology modeling complement each other in the exploration of the protein structure space. One of the challenges in using model information effectively has been to access all models available for a specific protein in heterogeneous formats at different sites using various incompatible accession code systems. Often, structure models for hundreds of proteins can be derived from a given experimentally determined structure, using a variety of established methods. This has been done by all of the PSI centers, and by various independent modeling groups. The goal of the Protein Model Portal (PMP) is to provide a single portal which gives access to the various models that can be leveraged from PSI targets and other experimental protein structures. A single interface allows all existing pre-computed models across these various sites to be queried simultaneously, and provides links to interactive services for template selection, target-template alignment, model building, and quality assessment. The current release of the portal consists of 7.6 million model structures provided by different partner resources (CSMP, JCSG, MCSG, NESG, NYSGXRC, JCMM, ModBase, SWISS-MODEL Repository). The PMP is available at http://www.proteinmodelportal.org and from the PSI Structural Genomics Knowledgebase.

  7. Modelling cointegration in the vector autoregressive model

    DEFF Research Database (Denmark)

    Johansen, Søren

    2000-01-01

    A survey is given of some results obtained for the cointegrated VAR. The Granger representation theorem is discussed and the notions of cointegration and common trends are defined. The statistical model for cointegrated I(1) variables is defined, and it is shown how hypotheses on the cointegratin...

  8. Developing mathematical modelling competence

    DEFF Research Database (Denmark)

    Blomhøj, Morten; Jensen, Tomas Højgaard

    2003-01-01

    In this paper we introduce the concept of mathematical modelling competence, by which we mean being able to carry through a whole mathematical modelling process in a certain context. Analysing the structure of this process, six sub-competences are identified. Mathematical modelling competence...... cannot be reduced to these six sub-competences, but they are necessary elements in the development of mathematical modelling competence. Experience from the development of a modelling course is used to illustrate how the different nature of the sub-competences can be used as a tool for finding...... the balance between different kinds of activities in a particular educational setting. Obstacles of social, cognitive and affective nature for the students' development of mathematical modelling competence are reported and discussed in relation to the sub-competences....

  9. Cloud model bat algorithm.

    Science.gov (United States)

    Zhou, Yongquan; Xie, Jian; Li, Liangliang; Ma, Mingzhi

    2014-01-01

    Bat algorithm (BA) is a novel stochastic global optimization algorithm. Cloud model is an effective tool in transforming between qualitative concepts and their quantitative representation. Based on the bat echolocation mechanism and excellent characteristics of cloud model on uncertainty knowledge representation, a new cloud model bat algorithm (CBA) is proposed. This paper focuses on remodeling echolocation model based on living and preying characteristics of bats, utilizing the transformation theory of cloud model to depict the qualitative concept: "bats approach their prey." Furthermore, Lévy flight mode and population information communication mechanism of bats are introduced to balance the advantage between exploration and exploitation. The simulation results show that the cloud model bat algorithm has good performance on functions optimization.

  10. Cloud Model Bat Algorithm

    Directory of Open Access Journals (Sweden)

    Yongquan Zhou

    2014-01-01

    Full Text Available Bat algorithm (BA is a novel stochastic global optimization algorithm. Cloud model is an effective tool in transforming between qualitative concepts and their quantitative representation. Based on the bat echolocation mechanism and excellent characteristics of cloud model on uncertainty knowledge representation, a new cloud model bat algorithm (CBA is proposed. This paper focuses on remodeling echolocation model based on living and preying characteristics of bats, utilizing the transformation theory of cloud model to depict the qualitative concept: “bats approach their prey.” Furthermore, Lévy flight mode and population information communication mechanism of bats are introduced to balance the advantage between exploration and exploitation. The simulation results show that the cloud model bat algorithm has good performance on functions optimization.

  11. Elements of modeling

    International Nuclear Information System (INIS)

    Bozoki, E.

    1987-01-01

    There is burgeoning interest in modeling-based accelerator control. With more and more stringent requirements on the performance, the importance of knowing, controlling, predicting the behavior of the accelerator system is growing. Modeling means two things: (1) the development of programs and data which predict the outcome of a measurement, and (2) devising and performing measurements to find the machine physics parameter and their behavior under different conditions. These two sides should be tied together in an iterative process. With knowledge gained on the real system, the model will be modified, calibrated, and fine-tuned. The model of a system consists of data and the modeling program. The Modeling Based Control Programs (MBC) should in the on-line mode control, optimize, and correct the machine. In the off-line mode, the MBC is used to simulate the machine as well as explore and study its behavior and responses under a wide variety of circumstances. 15 refs., 3 figs

  12. Inverse and Predictive Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Syracuse, Ellen Marie [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-09-27

    The LANL Seismo-Acoustic team has a strong capability in developing data-driven models that accurately predict a variety of observations. These models range from the simple – one-dimensional models that are constrained by a single dataset and can be used for quick and efficient predictions – to the complex – multidimensional models that are constrained by several types of data and result in more accurate predictions. Team members typically build models of geophysical characteristics of Earth and source distributions at scales of 1 to 1000s of km, the techniques used are applicable for other types of physical characteristics at an even greater range of scales. The following cases provide a snapshot of some of the modeling work done by the Seismo- Acoustic team at LANL.

  13. Spatial cluster modelling

    CERN Document Server

    Lawson, Andrew B

    2002-01-01

    Research has generated a number of advances in methods for spatial cluster modelling in recent years, particularly in the area of Bayesian cluster modelling. Along with these advances has come an explosion of interest in the potential applications of this work, especially in epidemiology and genome research. In one integrated volume, this book reviews the state-of-the-art in spatial clustering and spatial cluster modelling, bringing together research and applications previously scattered throughout the literature. It begins with an overview of the field, then presents a series of chapters that illuminate the nature and purpose of cluster modelling within different application areas, including astrophysics, epidemiology, ecology, and imaging. The focus then shifts to methods, with discussions on point and object process modelling, perfect sampling of cluster processes, partitioning in space and space-time, spatial and spatio-temporal process modelling, nonparametric methods for clustering, and spatio-temporal ...

  14. The IIR evaluation model

    DEFF Research Database (Denmark)

    Borlund, Pia

    2003-01-01

    An alternative approach to evaluation of interactive information retrieval (IIR) systems, referred to as the IIR evaluation model, is proposed. The model provides a framework for the collection and analysis of IR interaction data. The aim of the model is two-fold: 1) to facilitate the evaluation...... of IIR systems as realistically as possible with reference to actual information searching and retrieval processes, though still in a relatively controlled evaluation environment; and 2) to calculate the IIR system performance taking into account the non-binary nature of the assigned relevance...... assessments. The IIR evaluation model is presented as an alternative to the system-driven Cranfield model (Cleverdon, Mills & Keen, 1966; Cleverdon & Keen, 1966) which still is the dominant approach to the evaluation of IR and IIR systems. Key elements of the IIR evaluation model are the use of realistic...

  15. Essentials of econophysics modelling

    CERN Document Server

    Slanina, Frantisek

    2014-01-01

    This book is a course in methods and models rooted in physics and used in modelling economic and social phenomena. It covers the discipline of econophysics, which creates an interface between physics and economics. Besides the main theme, it touches on the theory of complex networks and simulations of social phenomena in general. After a brief historical introduction, the book starts with a list of basic empirical data and proceeds to thorough investigation of mathematical and computer models. Many of the models are based on hypotheses of the behaviour of simplified agents. These comprise strategic thinking, imitation, herding, and the gem of econophysics, the so-called minority game. At the same time, many other models view the economic processes as interactions of inanimate particles. Here, the methods of physics are especially useful. Examples of systems modelled in such a way include books of stock-market orders, and redistribution of wealth among individuals. Network effects are investigated in the inter...

  16. Brain Network Modelling

    DEFF Research Database (Denmark)

    Andersen, Kasper Winther

    Three main topics are presented in this thesis. The first and largest topic concerns network modelling of functional Magnetic Resonance Imaging (fMRI) and Diffusion Weighted Imaging (DWI). In particular nonparametric Bayesian methods are used to model brain networks derived from resting state f...... for their ability to reproduce node clustering and predict unseen data. Comparing the models on whole brain networks, BCD and IRM showed better reproducibility and predictability than IDM, suggesting that resting state networks exhibit community structure. This also points to the importance of using models, which...... allow for complex interactions between all pairs of clusters. In addition, it is demonstrated how the IRM can be used for segmenting brain structures into functionally coherent clusters. A new nonparametric Bayesian network model is presented. The model builds upon the IRM and can be used to infer...

  17. Identification of physical models

    DEFF Research Database (Denmark)

    Melgaard, Henrik

    1994-01-01

    The problem of identification of physical models is considered within the frame of stochastic differential equations. Methods for estimation of parameters of these continuous time models based on descrete time measurements are discussed. The important algorithms of a computer program for ML or MAP...... design of experiments, which is for instance the design of an input signal that are optimal according to a criterion based on the information provided by the experiment. Also model validation is discussed. An important verification of a physical model is to compare the physical characteristics...... of the model with the available prior knowledge. The methods for identification of physical models have been applied in two different case studies. One case is the identification of thermal dynamics of building components. The work is related to a CEC research project called PASSYS (Passive Solar Components...

  18. Diaspora Business Model Innovation

    Directory of Open Access Journals (Sweden)

    Aki Harima

    2015-01-01

    Full Text Available This paper explores how diasporans achieve business model innovatin by using their unique resources. The hypothesis underlying the paper is that the unique backgrounds and resources of the diaspora businesses, due to diffrent sources of informatin and experiences as well as multile networks, contributes to business model innovatin in a distictie manner. We investiate the English school market in the Philippines which is established by East Asian diaspora who innovate a business model of conventinal English schools. Two case studies were conducted with Japanese diaspora English schools. Their business is analyzed using a business model canvas (Osterwalder & Pigneur, 2010 and contrasted with the conventinal business model. The empirical cases show that diaspora businesses use knowledge about their country of origin and engage with country of residence and multile networks in diffrent locatins and constellatins to identiy unique opportunitis, leading to a business model innovatin.

  19. Electricity market modeling trends

    International Nuclear Information System (INIS)

    Ventosa, Mariano; Baillo, Alvaro; Ramos, Andres; Rivier, Michel

    2005-01-01

    The trend towards competition in the electricity sector has led to efforts by the research community to develop decision and analysis support models adapted to the new market context. This paper focuses on electricity generation market modeling. Its aim is to help to identify, classify and characterize the somewhat confusing diversity of approaches that can be found in the technical literature on the subject. The paper presents a survey of the most relevant publications regarding electricity market modeling, identifying three major trends: optimization models, equilibrium models and simulation models. It introduces a classification according to their most relevant attributes. Finally, it identifies the most suitable approaches for conducting various types of planning studies or market analysis in this new context

  20. Alternative tsunami models

    Energy Technology Data Exchange (ETDEWEB)

    Tan, A; Lyatskaya, I [Department of Physics, Alabama A and M University, Normal, AL 35762 (United States)], E-mail: arjun.tan@aamu.edu

    2009-01-15

    The interesting papers by Margaritondo (2005 Eur. J. Phys. 26 401) and by Helene and Yamashita (2006 Eur. J. Phys. 27 855) analysed the great Indian Ocean tsunami of 2004 using a simple one-dimensional canal wave model, which was appropriate for undergraduate students in physics and related fields of discipline. In this paper, two additional, easily understandable models, suitable for the same level of readership, are proposed: one, a two-dimensional model in flat space, and two, the same on a spherical surface. The models are used to study the tsunami produced by the central Kuril earthquake of November 2006. It is shown that the two alternative models, especially the latter one, give better representations of the wave amplitude, especially at far-flung locations. The latter model further demonstrates the enhancing effect on the amplitude due to the curvature of the Earth for far-reaching tsunami propagation.

  1. Energy balance climate models

    Science.gov (United States)

    North, G. R.; Cahalan, R. F.; Coakley, J. A., Jr.

    1981-01-01

    An introductory survey of the global energy balance climate models is presented with an emphasis on analytical results. A sequence of increasingly complicated models involving ice cap and radiative feedback processes are solved, and the solutions and parameter sensitivities are studied. The model parameterizations are examined critically in light of many current uncertainties. A simple seasonal model is used to study the effects of changes in orbital elements on the temperature field. A linear stability theorem and a complete nonlinear stability analysis for the models are developed. Analytical solutions are also obtained for the linearized models driven by stochastic forcing elements. In this context the relation between natural fluctuation statistics and climate sensitivity is stressed.

  2. Multiscale Cancer Modeling

    Science.gov (United States)

    Macklin, Paul; Cristini, Vittorio

    2013-01-01

    Simulating cancer behavior across multiple biological scales in space and time, i.e., multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine hypotheses, focus experiments, and enable more accurate predictions. A growing number of examples illustrate the value of this approach in providing quantitative insight on the initiation, progression, and treatment of cancer. In this review, we introduce the most recent and important multiscale cancer modeling works that have successfully established a mechanistic link between different biological scales. Biophysical, biochemical, and biomechanical factors are considered in these models. We also discuss innovative, cutting-edge modeling methods that are moving predictive multiscale cancer modeling toward clinical application. Furthermore, because the development of multiscale cancer models requires a new level of collaboration among scientists from a variety of fields such as biology, medicine, physics, mathematics, engineering, and computer science, an innovative Web-based infrastructure is needed to support this growing community. PMID:21529163

  3. Los Alamos Programming Models

    Energy Technology Data Exchange (ETDEWEB)

    Bergen, Benjamin Karl [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-07-07

    This is the PDF of a powerpoint presentation from a teleconference on Los Alamos programming models. It starts by listing their assumptions for the programming models and then details a hierarchical programming model at the System Level and Node Level. Then it details how to map this to their internal nomenclature. Finally, a list is given of what they are currently doing in this regard.

  4. Modelling Meat Quality Attributes.

    OpenAIRE

    Farrell, Terence C.

    2001-01-01

    Recent meat demand models incorporate demand functions for cuts of meat rather than whole carcasses. However, parameters for “meat quality” are seldom included in such models. Modelling difficulty arises as meat cuts are heterogeneous in their quality attributes. Meat quality may be assessed by measurement of attributes including tenderness, juiciness and flavour. Cooking method and cooking time are the two primary factors that affect meat-eating quality. The purpose of this paper is to show ...

  5. AREST model description

    Energy Technology Data Exchange (ETDEWEB)

    Engel, D.W.; McGrail, B.P.

    1993-11-01

    The Office of Civilian Radioactive Waste Management and the Power Reactor and Nuclear Fuel Development Corporation of Japan (PNC) have supported the development of the Analytical Repository Source-Term (AREST) at Pacific Northwest Laboratory. AREST is a computer model developed to evaluate radionuclide release from an underground geologic repository. The AREST code can be used to calculate/estimate the amount and rate of each radionuclide that is released from the engineered barrier system (EBS) of the repository. The EBS is the man-made or disrupted area of the repository. AREST was designed as a system-level models to simulate the behavior of the total repository by combining process-level models for the release from an individual waste package or container. AREST contains primarily analytical models for calculating the release/transport of radionuclides to the lost rock that surrounds each waste package. Analytical models were used because of the small computational overhead that allows all the input parameters to be derived from a statistical distribution. Recently, a one-dimensional numerical model was also incorporated into AREST, to allow for more detailed modeling of the transport process with arbitrary length decay chains. The next step in modeling the EBS, is to develop a model that couples the probabilistic capabilities of AREST with a more detailed process model. This model will need to look at the reactive coupling of the processes that are involved with the release process. Such coupling would include: (1) the dissolution of the waste form, (2) the geochemical modeling of the groundwater, (3) the corrosion of the container overpacking, and (4) the backfill material, just to name a few. Several of these coupled processes are already incorporated in the current version of AREST.

  6. Conceptual IT model

    Science.gov (United States)

    Arnaoudova, Kristina; Stanchev, Peter

    2015-11-01

    The business processes are the key asset for every organization. The design of the business process models is the foremost concern and target among an organization's functions. Business processes and their proper management are intensely dependent on the performance of software applications and technology solutions. The paper is attempt for definition of new Conceptual model of IT service provider, it could be examined as IT focused Enterprise model, part of Enterprise Architecture (EA) school.

  7. The Protein Model Portal

    OpenAIRE

    Arnold, Konstantin; Kiefer, Florian; Kopp, J?rgen; Battey, James N. D.; Podvinec, Michael; Westbrook, John D.; Berman, Helen M.; Bordoli, Lorenza; Schwede, Torsten

    2008-01-01

    Structural Genomics has been successful in determining the structures of many unique proteins in a high throughput manner. Still, the number of known protein sequences is much larger than the number of experimentally solved protein structures. Homology (or comparative) modeling methods make use of experimental protein structures to build models for evolutionary related proteins. Thereby, experimental structure determination efforts and homology modeling complement each other in the exploratio...

  8. Modeling Frequency Comb Sources

    Directory of Open Access Journals (Sweden)

    Li Feng

    2016-06-01

    Full Text Available Frequency comb sources have revolutionized metrology and spectroscopy and found applications in many fields. Stable, low-cost, high-quality frequency comb sources are important to these applications. Modeling of the frequency comb sources will help the understanding of the operation mechanism and optimization of the design of such sources. In this paper,we review the theoretical models used and recent progress of the modeling of frequency comb sources.

  9. Garch-EVT Model

    OpenAIRE

    Altun, Emrah; Tatlidil, Hüseyin

    2016-01-01

    In this study, wavelet based GARCH-Extreme Value Theory (EVT) is proposed to model financial return series to forecast daily value-at-risk. Wavelets based GARCH-EVT is hybrid model combining the wavelet analysis and EVT. Proposed model contains three stages. In first stage, return series is decomposed into wavelet series and approximation series by applying the maximal overlap discrete wavelet transform. Second stage, detrended return series and approximation series are obtained by using wave...

  10. Liftoff Model for MELCOR.

    Energy Technology Data Exchange (ETDEWEB)

    Young, Michael F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-07-01

    Aerosol particles that deposit on surfaces may be subsequently resuspended by air flowing over the surface. A review of models for this liftoff process is presented and compared to available data. Based on this review, a model that agrees with existing data and is readily computed is presented for incorporation into a system level code such as MELCOR. Liftoff Model for MELCOR July 2015 4 This page is intentionally blank

  11. Beyond the standard model

    International Nuclear Information System (INIS)

    Wilczek, F.

    1993-01-01

    The standard model of particle physics is highly successful, although it is obviously not a complete or final theory. In this presentation the author argues that the structure of the standard model gives some quite concrete, compelling hints regarding what lies beyond. Essentially, this presentation is a record of the author's own judgement of what the central clues for physics beyond the standard model are, and also it is an attempt at some pedagogy. 14 refs., 6 figs

  12. Standard Model processes

    CERN Document Server

    Mangano, M.L.; Aguilar-Saavedra, Juan Antonio; Alekhin, S.; Badger, S.; Bauer, C.W.; Becher, T.; Bertone, V.; Bonvini, M.; Boselli, S.; Bothmann, E.; Boughezal, R.; Cacciari, M.; Carloni Calame, C.M.; Caola, F.; Campbell, J.M.; Carrazza, S.; Chiesa, M.; Cieri, L.; Cimaglia, F.; Febres Cordero, F.; Ferrarese, P.; D'Enterria, D.; Ferrera, G.; Garcia i Tormo, X.; Garzelli, M.V.; Germann, E.; Hirschi, V.; Han, T.; Ita, H.; Jäger, B.; Kallweit, S.; Karlberg, A.; Kuttimalai, S.; Krauss, F.; Larkoski, A.J.; Lindert, J.; Luisoni, G.; Maierhöfer, P.; Mattelaer, O.; Martinez, H.; Moch, S.; Montagna, G.; Moretti, M.; Nason, P.; Nicrosini, O.; Oleari, C.; Pagani, D.; Papaefstathiou, A.; Petriello, F.; Piccinini, F.; Pierini, M.; Pierog, T.; Pozzorini, S.; Re, E.; Robens, T.; Rojo, J.; Ruiz, R.; Sakurai, K.; Salam, G.P.; Salfelder, L.; Schönherr, M.; Schulze, M.; Schumann, S.; Selvaggi, M.; Shivaji, A.; Siodmok, A.; Skands, P.; Torrielli, P.; Tramontano, F.; Tsinikos, I.; Tweedie, B.; Vicini, A.; Westhoff, S.; Zaro, M.; Zeppenfeld, D.; CERN. Geneva. ATS Department

    2017-06-22

    This report summarises the properties of Standard Model processes at the 100 TeV pp collider. We document the production rates and typical distributions for a number of benchmark Standard Model processes, and discuss new dynamical phenomena arising at the highest energies available at this collider. We discuss the intrinsic physics interest in the measurement of these Standard Model processes, as well as their role as backgrounds for New Physics searches.

  13. AREST model description

    International Nuclear Information System (INIS)

    Engel, D.W.; McGrail, B.P.

    1993-11-01

    The Office of Civilian Radioactive Waste Management and the Power Reactor and Nuclear Fuel Development Corporation of Japan (PNC) have supported the development of the Analytical Repository Source-Term (AREST) at Pacific Northwest Laboratory. AREST is a computer model developed to evaluate radionuclide release from an underground geologic repository. The AREST code can be used to calculate/estimate the amount and rate of each radionuclide that is released from the engineered barrier system (EBS) of the repository. The EBS is the man-made or disrupted area of the repository. AREST was designed as a system-level models to simulate the behavior of the total repository by combining process-level models for the release from an individual waste package or container. AREST contains primarily analytical models for calculating the release/transport of radionuclides to the lost rock that surrounds each waste package. Analytical models were used because of the small computational overhead that allows all the input parameters to be derived from a statistical distribution. Recently, a one-dimensional numerical model was also incorporated into AREST, to allow for more detailed modeling of the transport process with arbitrary length decay chains. The next step in modeling the EBS, is to develop a model that couples the probabilistic capabilities of AREST with a more detailed process model. This model will need to look at the reactive coupling of the processes that are involved with the release process. Such coupling would include: (1) the dissolution of the waste form, (2) the geochemical modeling of the groundwater, (3) the corrosion of the container overpacking, and (4) the backfill material, just to name a few. Several of these coupled processes are already incorporated in the current version of AREST

  14. Vacuum inhomogeneous cosmological models

    International Nuclear Information System (INIS)

    Hanquin, J.-L.

    1984-01-01

    The author presents some results concerning the vacuum cosmological models which admit a 2-dimensional Abelian group of isometries: classifications of these space-times based on the topological nature of their space-like hypersurfaces and on their time evolution, analysis of the asymptotical behaviours at spatial infinity for hyperbolical models as well as in the neighbourhood of the singularity for the models possessing a time singularity during their evolution. (Auth.)

  15. Beyond the standard model

    International Nuclear Information System (INIS)

    Pleitez, V.

    1994-01-01

    The search for physics laws beyond the standard model is discussed in a general way, and also some topics on supersymmetry theories. An approach is made on recent possibilities rise in the leptonic sector. Finally, models with SU(3) c X SU(2) L X U(1) Y symmetry are considered as alternatives for the extensions of the elementary particles standard model. 36 refs., 1 fig., 4 tabs

  16. Transgenesis for pig models

    OpenAIRE

    Yum, Soo-Young; Yoon, Ki-Young; Lee, Choong-Il; Lee, Byeong-Chun; Jang, Goo

    2016-01-01

    Animal models, particularly pigs, have come to play an important role in translational biomedical research. There have been many pig models with genetically modifications via somatic cell nuclear transfer (SCNT). However, because most transgenic pigs have been produced by random integration to date, the necessity for more exact gene-mutated models using recombinase based conditional gene expression like mice has been raised. Currently, advanced genome-editing technologies enable us to generat...

  17. Wind power prediction models

    Science.gov (United States)

    Levy, R.; Mcginness, H.

    1976-01-01

    Investigations were performed to predict the power available from the wind at the Goldstone, California, antenna site complex. The background for power prediction was derived from a statistical evaluation of available wind speed data records at this location and at nearby locations similarly situated within the Mojave desert. In addition to a model for power prediction over relatively long periods of time, an interim simulation model that produces sample wind speeds is described. The interim model furnishes uncorrelated sample speeds at hourly intervals that reproduce the statistical wind distribution at Goldstone. A stochastic simulation model to provide speed samples representative of both the statistical speed distributions and correlations is also discussed.

  18. Models of molecular geometry.

    Science.gov (United States)

    Gillespie, Ronald J; Robinson, Edward A

    2005-05-01

    Although the structure of almost any molecule can now be obtained by ab initio calculations chemists still look for simple answers to the question "What determines the geometry of a given molecule?" For this purpose they make use of various models such as the VSEPR model and qualitative quantum mechanical models such as those based on the valence bond theory. The present state of such models, and the support for them provided by recently developed methods for analyzing calculated electron densities, are reviewed and discussed in this tutorial review.

  19. Croatian Cadastre Database Modelling

    Directory of Open Access Journals (Sweden)

    Zvonko Biljecki

    2013-04-01

    Full Text Available The Cadastral Data Model has been developed as a part of a larger programme to improve products and production environment of the Croatian Cadastral Service of the State Geodetic Administration (SGA. The goal of the project was to create a cadastral data model conforming to relevant standards and specifications in the field of geoinformation (GI adapted by international organisations for standardisation under the competence of GI (ISO TC211 and OpenGIS and it implementations.The main guidelines during the project have been object-oriented conceptual modelling of the updated users' requests and a "new" cadastral data model designed by SGA - Faculty of Geodesy - Geofoto LLC project team. The UML of the conceptual model is given per all feature categories and is described only at class level. The next step was the UML technical model, which was developed from the UML conceptual model. The technical model integrates different UML schemas in one united schema.XML (eXtensible Markup Language was applied for XML description of UML models, and then the XML schema was transferred into GML (Geography Markup Language application schema. With this procedure we have completely described the behaviour of each cadastral feature and rules for the transfer and storage of cadastral features into the database.

  20. Graphical Models with R

    CERN Document Server

    Højsgaard, Søren; Lauritzen, Steffen

    2012-01-01

    Graphical models in their modern form have been around since the late 1970s and appear today in many areas of the sciences. Along with the ongoing developments of graphical models, a number of different graphical modeling software programs have been written over the years. In recent years many of these software developments have taken place within the R community, either in the form of new packages or by providing an R interface to existing software. This book attempts to give the reader a gentle introduction to graphical modeling using R and the main features of some of these packages. In add