WorldWideScience

Sample records for models including additional

  1. The Additive Hazard Mixing Models

    Institute of Scientific and Technical Information of China (English)

    Ping LI; Xiao-liang LING

    2012-01-01

    This paper is concerned with the aging and dependence properties in the additive hazard mixing models including some stochastic comparisons.Further,some useful bounds of reliability functions in additive hazard mixing models are obtained.

  2. Constant-Pressure Combustion Charts Including Effects of Diluent Addition

    Science.gov (United States)

    Turner, L Richard; Bogart, Donald

    1949-01-01

    Charts are presented for the calculation of (a) the final temperatures and the temperature changes involved in constant-pressure combustion processes of air and in products of combustion of air and hydrocarbon fuels, and (b) the quantity of hydrocarbon fuels required in order to attain a specified combustion temperature when water, alcohol, water-alcohol mixtures, liquid ammonia, liquid carbon dioxide, liquid nitrogen, liquid oxygen, or their mixtures are added to air as diluents or refrigerants. The ideal combustion process and combustion with incomplete heat release from the primary fuel and from combustible diluents are considered. The effect of preheating the mixture of air and diluents and the effect of an initial water-vapor content in the combustion air on the required fuel quantity are also included. The charts are applicable only to processes in which the final mixture is leaner than stoichiometric and at temperatures where dissociation is unimportant. A chart is also included to permit the calculation of the stoichiometric ratio of hydrocarbon fuel to air with diluent addition. The use of the charts is illustrated by numerical examples.

  3. Mixed additive models

    Science.gov (United States)

    Carvalho, Francisco; Covas, Ricardo

    2016-06-01

    We consider mixed models y =∑i =0 w Xiβi with V (y )=∑i =1 w θiMi Where Mi=XiXi⊤ , i = 1, . . ., w, and µ = X0β0. For these we will estimate the variance components θ1, . . ., θw, aswell estimable vectors through the decomposition of the initial model into sub-models y(h), h ∈ Γ, with V (y (h ))=γ (h )Ig (h )h ∈Γ . Moreover we will consider L extensions of these models, i.e., y˚=Ly+ɛ, where L=D (1n1, . . ., 1nw) and ɛ, independent of y, has null mean vector and variance covariance matrix θw+1Iw, where w =∑i =1 n wi .

  4. Including Magnetostriction in Micromagnetic Models

    Science.gov (United States)

    Conbhuí, Pádraig Ó.; Williams, Wyn; Fabian, Karl; Nagy, Lesleis

    2016-04-01

    The magnetic anomalies that identify crustal spreading are predominantly recorded by basalts formed at the mid-ocean ridges, whose magnetic signals are dominated by iron-titanium-oxides (Fe3-xTixO4), so called "titanomagnetites", of which the Fe2.4Ti0.6O4 (TM60) phase is the most common. With sufficient quantities of titanium present, these minerals exhibit strong magnetostriction. To date, models of these grains in the pseudo-single domain (PSD) range have failed to accurately account for this effect. In particular, a popular analytic treatment provided by Kittel (1949) for describing the magnetostrictive energy as an effective increase of the anisotropy constant can produce unphysical strains for non-uniform magnetizations. I will present a rigorous approach based on work by Brown (1966) and by Kroner (1958) for including magnetostriction in micromagnetic codes which is suitable for modelling hysteresis loops and finding remanent states in the PSD regime. Preliminary results suggest the more rigorously defined micromagnetic models exhibit higher coercivities and extended single domain ranges when compared to more simplistic approaches.

  5. Business models for additive manufacturing

    DEFF Research Database (Denmark)

    Hadar, Ronen; Bilberg, Arne; Bogers, Marcel

    2015-01-01

    Digital fabrication — including additive manufacturing (AM), rapid prototyping and 3D printing — has the potential to revolutionize the way in which products are produced and delivered to the customer. Therefore, it challenges companies to reinvent their business model — describing the logic...... of creating and capturing value. In this paper, we explore the implications that AM technologies have for manufacturing systems in the new business models that they enable. In particular, we consider how a consumer goods manufacturer can organize the operations of a more open business model when moving from...... a manufacturer-centric to a consumer-centric value logic. A major shift includes a move from centralized to decentralized supply chains, where consumer goods manufacturers can implement a “hybrid” approach with a focus on localization and accessibility or develop a fully personalized model where the consumer...

  6. DEVELOPMENT OF WATER CIRCULATION MODEL INCLUDING IRRIGATION

    Science.gov (United States)

    Kotsuki, Shunji; Tanaka, Kenji; Kojiri, Toshiharu; Hamaguchi, Toshio

    It is well known that since agricultural water withdrawal has much affect on water circulation system, accurate analysis of river discharge or water balance are difficult with less regard for it. In this study, water circulation model composed of land surface model and distributed runoff model is proposed at 10km 10km resolution. In this model, irrigation water, which is estimated with land surface model, is introduced to river discharge analysis. The model is applied to the Chao Phraya River in Thailand, and reproduced seasonal water balance. Additionally, the discharge on dry season simulated with the model is improved as a result of including irrigation. Since the model, which is basically developed from global data sets, simulated seasonal change of river discharge, it can be suggested that our model has university to other river basins.

  7. An Integrated Biochemistry Laboratory, Including Molecular Modeling

    Science.gov (United States)

    Hall, Adele J. Wolfson Mona L.; Branham, Thomas R.

    1996-11-01

    ) experience with methods of protein purification; (iii) incorporation of appropriate controls into experiments; (iv) use of basic statistics in data analysis; (v) writing papers and grant proposals in accepted scientific style; (vi) peer review; (vii) oral presentation of results and proposals; and (viii) introduction to molecular modeling. Figure 1 illustrates the modular nature of the lab curriculum. Elements from each of the exercises can be separated and treated as stand-alone exercises, or combined into short or long projects. We have been able to offer the opportunity to use sophisticated molecular modeling in the final module through funding from an NSF-ILI grant. However, many of the benefits of the research proposal can be achieved with other computer programs, or even by literature survey alone. Figure 1.Design of project-based biochemistry laboratory. Modules (projects, or portions of projects) are indicated as boxes. Each of these can be treated independently, or used as part of a larger project. Solid lines indicate some suggested paths from one module to the next. The skills and knowledge required for protein purification and design are developed in three units: (i) an introduction to critical assays needed to monitor degree of purification, including an evaluation of assay parameters; (ii) partial purification by ion-exchange techniques; and (iii) preparation of a grant proposal on protein design by mutagenesis. Brief descriptions of each of these units follow, with experimental details of each project at the end of this paper. Assays for Lysozyme Activity and Protein Concentration (4 weeks) The assays mastered during the first unit are a necessary tool for determining the purity of the enzyme during the second unit on purification by ion exchange. These assays allow an introduction to the concept of specific activity (units of enzyme activity per milligram of total protein) as a measure of purity. In this first sequence, students learn a turbidimetric assay

  8. Models of bovine babesiosis including juvenile cattle.

    Science.gov (United States)

    Saad-Roy, C M; Shuai, Zhisheng; van den Driessche, P

    2015-03-01

    Bovine Babesiosis in cattle is caused by the transmission of protozoa of Babesia spp. by ticks as vectors. Juvenile cattle (Babesiosis, rarely show symptoms, and acquire immunity upon recovery. Susceptibility to the disease varies between breeds of cattle. Models of the dynamics of Bovine Babesiosis transmitted by the cattle tick that include these factors are formulated as systems of ordinary differential equations. Basic reproduction numbers are calculated, and it is proved that if these numbers are below the threshold value of one, then Bovine Babesiosis dies out. However, above the threshold number of one, the disease may approach an endemic state. In this case, control measures are suggested by determining target reproduction numbers. The percentage of a particular population (for example, the adult bovine population) needed to be controlled to eradicate the disease is evaluated numerically using Columbia data from the literature.

  9. Systems and Methods for Fabricating Objects Including Amorphous Metal Using Techniques Akin to Additive Manufacturing

    Science.gov (United States)

    Hofmann, Douglas (Inventor)

    2017-01-01

    Systems and methods in accordance with embodiments of the invention fabricate objects including amorphous metals using techniques akin to additive manufacturing. In one embodiment, a method of fabricating an object that includes an amorphous metal includes: applying a first layer of molten metallic alloy to a surface; cooling the first layer of molten metallic alloy such that it solidifies and thereby forms a first layer including amorphous metal; subsequently applying at least one layer of molten metallic alloy onto a layer including amorphous metal; cooling each subsequently applied layer of molten metallic alloy such that it solidifies and thereby forms a layer including amorphous metal prior to the application of any adjacent layer of molten metallic alloy; where the aggregate of the solidified layers including amorphous metal forms a desired shape in the object to be fabricated; and removing at least the first layer including amorphous metal from the surface.

  10. Expanding the North American Breeding Bird Survey analysis to include additional species and regions

    Science.gov (United States)

    Sauer, John; Niven, Daniel; Pardieck, Keith L.; Ziolkowski, David; Link, William

    2017-01-01

    The North American Breeding Bird Survey (BBS) contains data for >700 bird species, but analyses often focus on a core group of ∼420 species. We analyzed data for 122 species of North American birds for which data exist in the North American Breeding Bird Survey (BBS) database but are not routinely analyzed on the BBS Summary and Analysis Website. Many of these species occur in the northern part of the continent, on routes that fall outside the core survey area presently analyzed in the United States and southern Canada. Other species not historically analyzed occur in the core survey area with very limited data but have large portions of their ranges in Mexico and south. A third group of species not historically analyzed included species thought to be poorly surveyed by the BBS, such as rare, coastal, or nocturnal species. For 56 species found primarily in regions north of the core survey area, we expanded the scope of the analysis, using data from 1993 to 2014 during which ≥3 survey routes had been sampled in 6 northern strata (Bird Conservation regions in Alaska, Yukon, and Newfoundland and Labrador) and fitting log-linear hierarchical models for an augmented BBS survey area that included both the new northern strata and the core survey area. We also applied this model to 168 species historically analyzed in the BBS that had data from these additional northern strata. For both groups of species we calculated survey-wide trends for the both core and augmented survey areas from 1993 to 2014; for species that did not occur in the newly defined strata, we computed trends from 1966 to 2014. We evaluated trend estimates in terms of established credibility criteria for BBS results, screening for imprecise trends, small samples, and low relative abundance. Inclusion of data from the northern strata permitted estimation of trend for 56 species not historically analyzed, but only 4 of these were reasonably monitored and an additional 13 were questionably monitored; 39

  11. A revised list of the mosquitoes of North Dakota, including new additions to the fauna.

    Science.gov (United States)

    Darsie, R F; Anderson, A W

    1985-03-01

    An up-to-date list of the mosquitoes known to occur in North Dakota is given. It includes 38 species in 8 genera. Aedes hendersoni, Ae. melanimon, and Culiseta minnesotae are being reported for the first time. In addition, 6 other species that probably belong to the state's fauna are discussed.

  12. Seepage Model for PA Including Dift Collapse

    Energy Technology Data Exchange (ETDEWEB)

    G. Li; C. Tsang

    2000-12-20

    The purpose of this Analysis/Model Report (AMR) is to document the predictions and analysis performed using the Seepage Model for Performance Assessment (PA) and the Disturbed Drift Seepage Submodel for both the Topopah Spring middle nonlithophysal and lower lithophysal lithostratigraphic units at Yucca Mountain. These results will be used by PA to develop the probability distribution of water seepage into waste-emplacement drifts at Yucca Mountain, Nevada, as part of the evaluation of the long term performance of the potential repository. This AMR is in accordance with the ''Technical Work Plan for Unsaturated Zone (UZ) Flow and Transport Process Model Report'' (CRWMS M&O 2000 [153447]). This purpose is accomplished by performing numerical simulations with stochastic representations of hydrological properties, using the Seepage Model for PA, and evaluating the effects of an alternative drift geometry representing a partially collapsed drift using the Disturbed Drift Seepage Submodel. Seepage of water into waste-emplacement drifts is considered one of the principal factors having the greatest impact of long-term safety of the repository system (CRWMS M&O 2000 [153225], Table 4-1). This AMR supports the analysis and simulation that are used by PA to develop the probability distribution of water seepage into drift, and is therefore a model of primary (Level 1) importance (AP-3.15Q, ''Managing Technical Product Inputs''). The intended purpose of the Seepage Model for PA is to support: (1) PA; (2) Abstraction of Drift-Scale Seepage; and (3) Unsaturated Zone (UZ) Flow and Transport Process Model Report (PMR). Seepage into drifts is evaluated by applying numerical models with stochastic representations of hydrological properties and performing flow simulations with multiple realizations of the permeability field around the drift. The Seepage Model for PA uses the distribution of permeabilities derived from air injection testing in

  13. Enhanced battery model including temperature effects

    NARCIS (Netherlands)

    Rosca, B.; Wilkins, S.

    2013-01-01

    Within electric and hybrid vehicles, batteries are used to provide/buffer the energy required for driving. However, battery performance varies throughout the temperature range specific to automotive applications, and as such, models that describe this behaviour are required. This paper presents a dy

  14. Enhanced battery model including temperature effects

    NARCIS (Netherlands)

    Rosca, B.; Wilkins, S.

    2013-01-01

    Within electric and hybrid vehicles, batteries are used to provide/buffer the energy required for driving. However, battery performance varies throughout the temperature range specific to automotive applications, and as such, models that describe this behaviour are required. This paper presents a dy

  15. Enhanced battery model including temperature effects

    NARCIS (Netherlands)

    Rosca, B.; Wilkins, S.

    2013-01-01

    Within electric and hybrid vehicles, batteries are used to provide/buffer the energy required for driving. However, battery performance varies throughout the temperature range specific to automotive applications, and as such, models that describe this behaviour are required. This paper presents a

  16. The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops.

    Science.gov (United States)

    Pokhilko, Alexandra; Fernández, Aurora Piñas; Edwards, Kieron D; Southern, Megan M; Halliday, Karen J; Millar, Andrew J

    2012-03-06

    Circadian clocks synchronise biological processes with the day/night cycle, using molecular mechanisms that include interlocked, transcriptional feedback loops. Recent experiments identified the evening complex (EC) as a repressor that can be essential for gene expression rhythms in plants. Integrating the EC components in this role significantly alters our mechanistic, mathematical model of the clock gene circuit. Negative autoregulation of the EC genes constitutes the clock's evening loop, replacing the hypothetical component Y. The EC explains our earlier conjecture that the morning gene Pseudo-Response Regulator 9 was repressed by an evening gene, previously identified with Timing Of CAB Expression1 (TOC1). Our computational analysis suggests that TOC1 is a repressor of the morning genes Late Elongated Hypocotyl and Circadian Clock Associated1 rather than an activator as first conceived. This removes the necessity for the unknown component X (or TOC1mod) from previous clock models. As well as matching timeseries and phase-response data, the model provides a new conceptual framework for the plant clock that includes a three-component repressilator circuit in its complex structure.

  17. EVAPORATION: a new vapour pressure estimation methodfor organic molecules including non-additivity and intramolecular interactions

    Directory of Open Access Journals (Sweden)

    S. Compernolle

    2011-09-01

    Full Text Available We present EVAPORATION (Estimation of VApour Pressure of ORganics, Accounting for Temperature, Intramolecular, and Non-additivity effects, a method to predict (subcooled liquid pure compound vapour pressure p0 of organic molecules that requires only molecular structure as input. The method is applicable to zero-, mono- and polyfunctional molecules. A simple formula to describe log10p0(T is employed, that takes into account both a wide temperature dependence and the non-additivity of functional groups. In order to match the recent data on functionalised diacids an empirical modification to the method was introduced. Contributions due to carbon skeleton, functional groups, and intramolecular interaction between groups are included. Molecules typically originating from oxidation of biogenic molecules are within the scope of this method: aldehydes, ketones, alcohols, ethers, esters, nitrates, acids, peroxides, hydroperoxides, peroxy acyl nitrates and peracids. Therefore the method is especially suited to describe compounds forming secondary organic aerosol (SOA.

  18. A model of Barchan dunes including lateral shear stress.

    Science.gov (United States)

    Schwämmle, V; Herrmann, H J

    2005-01-01

    Barchan dunes are found where sand availability is low and wind direction quite constant. The two dimensional shear stress of the wind field and the sand movement by saltation and avalanches over a barchan dune are simulated. The model with one dimensional shear stress is extended including surface diffusion and lateral shear stress. The resulting final shape is compared to the results of the model with a one dimensional shear stress and confirmed by comparison to measurements. We found agreement and improvements with respect to the model with one dimensional shear stress. Additionally, a characteristic edge at the center of the windward side is discovered which is also observed for big barchans. Diffusion effects reduce this effect for small dunes.

  19. Identifying confounders using additive noise models

    CERN Document Server

    Janzing, Dominik; Mooij, Joris; Schoelkopf, Bernhard

    2012-01-01

    We propose a method for inferring the existence of a latent common cause ('confounder') of two observed random variables. The method assumes that the two effects of the confounder are (possibly nonlinear) functions of the confounder plus independent, additive noise. We discuss under which conditions the model is identifiable (up to an arbitrary reparameterization of the confounder) from the joint distribution of the effects. We state and prove a theoretical result that provides evidence for the conjecture that the model is generically identifiable under suitable technical conditions. In addition, we propose a practical method to estimate the confounder from a finite i.i.d. sample of the effects and illustrate that the method works well on both simulated and real-world data.

  20. A generalized additive regression model for survival times

    DEFF Research Database (Denmark)

    Scheike, Thomas H.

    2001-01-01

    Additive Aalen model; counting process; disability model; illness-death model; generalized additive models; multiple time-scales; non-parametric estimation; survival data; varying-coefficient models......Additive Aalen model; counting process; disability model; illness-death model; generalized additive models; multiple time-scales; non-parametric estimation; survival data; varying-coefficient models...

  1. A generalized additive regression model for survival times

    DEFF Research Database (Denmark)

    Scheike, Thomas H.

    2001-01-01

    Additive Aalen model; counting process; disability model; illness-death model; generalized additive models; multiple time-scales; non-parametric estimation; survival data; varying-coefficient models......Additive Aalen model; counting process; disability model; illness-death model; generalized additive models; multiple time-scales; non-parametric estimation; survival data; varying-coefficient models...

  2. Additional records of metazoan parasites from Caribbean marine mammals, including genetically identified anisakid nematodes.

    Science.gov (United States)

    Colón-Llavina, Marlene M; Mignucci-Giannoni, Antonio A; Mattiucci, Simonetta; Paoletti, Michela; Nascetti, Giuseppe; Williams, Ernest H

    2009-10-01

    Studies of marine mammal parasites in the Caribbean are scarce. An assessment for marine mammal endo- and ectoparasites from Puerto Rico and the Virgin Islands, but extending to other areas of the Caribbean, was conducted between 1989 and 1994. The present study complements the latter and enhances identification of anisakid nematodes using molecular markers. Parasites were collected from 59 carcasses of stranded cetaceans and manatees from 1994 to 2006, including Globicephala macrorhynchus, Kogia breviceps, Kogia sima, Lagenodelphis hosei, Mesoplodon densirostris, Peponocephala electra, Stenella longirostris, Steno bredanensis, Trichechus manatus. Tursiops truncatus, and Ziphius cavirostris. Sixteen species of endoparasitic helminthes were morphologically identified, including two species of acanthocephalans (Bolbosoma capitatum, Bolbosoma vasculosum), nine species of nematodes (Anisakis sp., Anisakis brevispiculata, Anisakis paggiae, Anisakis simplex, Anisakis typica, Anisakis ziphidarium, Crassicauda anthonyi, Heterocheilus tunicatus, Pseudoterranova ceticola), two species of cestodes (Monorygma grimaldi, Phyllobothrium delphini), and three species of trematodes (Chiorchis groschafti, Pulmonicola cochleotrema, Monoligerum blairi). The nematodes belonging to the genus Anisakis recovered in some stranded animals were genetically identified to species level based on their sequence analysis of mitochondrial DNA (629 bp of mtDNA cox 2). A total of five new host records and six new geographic records are presented.

  3. Computational Process Modeling for Additive Manufacturing (OSU)

    Science.gov (United States)

    Bagg, Stacey; Zhang, Wei

    2015-01-01

    Powder-Bed Additive Manufacturing (AM) through Direct Metal Laser Sintering (DMLS) or Selective Laser Melting (SLM) is being used by NASA and the Aerospace industry to "print" parts that traditionally are very complex, high cost, or long schedule lead items. The process spreads a thin layer of metal powder over a build platform, then melts the powder in a series of welds in a desired shape. The next layer of powder is applied, and the process is repeated until layer-by-layer, a very complex part can be built. This reduces cost and schedule by eliminating very complex tooling and processes traditionally used in aerospace component manufacturing. To use the process to print end-use items, NASA seeks to understand SLM material well enough to develop a method of qualifying parts for space flight operation. Traditionally, a new material process takes many years and high investment to generate statistical databases and experiential knowledge, but computational modeling can truncate the schedule and cost -many experiments can be run quickly in a model, which would take years and a high material cost to run empirically. This project seeks to optimize material build parameters with reduced time and cost through modeling.

  4. CREATION OF THE MODEL ADDITIONAL PROTOCOL

    Energy Technology Data Exchange (ETDEWEB)

    Houck, F.; Rosenthal, M.; Wulf, N.

    2010-05-25

    In 1991, the international nuclear nonproliferation community was dismayed to discover that the implementation of safeguards by the International Atomic Energy Agency (IAEA) under its NPT INFCIRC/153 safeguards agreement with Iraq had failed to detect Iraq's nuclear weapon program. It was now clear that ensuring that states were fulfilling their obligations under the NPT would require not just detecting diversion but also the ability to detect undeclared materials and activities. To achieve this, the IAEA initiated what would turn out to be a five-year effort to reappraise the NPT safeguards system. The effort engaged the IAEA and its Member States and led to agreement in 1997 on a new safeguards agreement, the Model Protocol Additional to the Agreement(s) between States and the International Atomic Energy Agency for the Application of Safeguards. The Model Protocol makes explicit that one IAEA goal is to provide assurance of the absence of undeclared nuclear material and activities. The Model Protocol requires an expanded declaration that identifies a State's nuclear potential, empowers the IAEA to raise questions about the correctness and completeness of the State's declaration, and, if needed, allows IAEA access to locations. The information required and the locations available for access are much broader than those provided for under INFCIRC/153. The negotiation was completed in quite a short time because it started with a relatively complete draft of an agreement prepared by the IAEA Secretariat. This paper describes how the Model Protocol was constructed and reviews key decisions that were made both during the five-year period and in the actual negotiation.

  5. Numerical Modeling of Electroacoustic Logging Including Joule Heating

    Science.gov (United States)

    Plyushchenkov, Boris D.; Nikitin, Anatoly A.; Turchaninov, Victor I.

    It is well known that electromagnetic field excites acoustic wave in a porous elastic medium saturated with fluid electrolyte due to electrokinetic conversion effect. Pride's equations describing this process are written in isothermal approximation. Update of these equations, which allows to take influence of Joule heating on acoustic waves propagation into account, is proposed here. This update includes terms describing the initiation of additional acoustic waves excited by thermoelastic stresses and the heat conduction equation with right side defined by Joule heating. Results of numerical modeling of several problems of propagation of acoustic waves excited by an electric field source with and without consideration of Joule heating effect in their statements are presented. From these results, it follows that influence of Joule heating should be taken into account at the numerical simulation of electroacoustic logging and at the interpretation of its log data.

  6. Fitting Additive Binomial Regression Models with the R Package blm

    Directory of Open Access Journals (Sweden)

    Stephanie Kovalchik

    2013-09-01

    Full Text Available The R package blm provides functions for fitting a family of additive regression models to binary data. The included models are the binomial linear model, in which all covariates have additive effects, and the linear-expit (lexpit model, which allows some covariates to have additive effects and other covariates to have logisitc effects. Additive binomial regression is a model of event probability, and the coefficients of linear terms estimate covariate-adjusted risk differences. Thus, in contrast to logistic regression, additive binomial regression puts focus on absolute risk and risk differences. In this paper, we give an overview of the methodology we have developed to fit the binomial linear and lexpit models to binary outcomes from cohort and population-based case-control studies. We illustrate the blm packages methods for additive model estimation, diagnostics, and inference with risk association analyses of a bladder cancer nested case-control study in the NIH-AARP Diet and Health Study.

  7. Dynamic hysteresis modeling including skin effect using diffusion equation model

    Science.gov (United States)

    Hamada, Souad; Louai, Fatima Zohra; Nait-Said, Nasreddine; Benabou, Abdelkader

    2016-07-01

    An improved dynamic hysteresis model is proposed for the prediction of hysteresis loop of electrical steel up to mean frequencies, taking into account the skin effect. In previous works, the analytical solution of the diffusion equation for low frequency (DELF) was coupled with the inverse static Jiles-Atherton (JA) model in order to represent the hysteresis behavior for a lamination. In the present paper, this approach is improved to ensure the reproducibility of measured hysteresis loops at mean frequency. The results of simulation are compared with the experimental ones. The selected results for frequencies 50 Hz, 100 Hz, 200 Hz and 400 Hz are presented and discussed.

  8. Dynamic hysteresis modeling including skin effect using diffusion equation model

    Energy Technology Data Exchange (ETDEWEB)

    Hamada, Souad, E-mail: souadhamada@yahoo.fr [LSP-IE: Research Laboratory, Electrical Engineering Department, University of Batna, 05000 Batna (Algeria); Louai, Fatima Zohra, E-mail: fz_louai@yahoo.com [LSP-IE: Research Laboratory, Electrical Engineering Department, University of Batna, 05000 Batna (Algeria); Nait-Said, Nasreddine, E-mail: n_naitsaid@yahoo.com [LSP-IE: Research Laboratory, Electrical Engineering Department, University of Batna, 05000 Batna (Algeria); Benabou, Abdelkader, E-mail: Abdelkader.Benabou@univ-lille1.fr [L2EP, Université de Lille1, 59655 Villeneuve d’Ascq (France)

    2016-07-15

    An improved dynamic hysteresis model is proposed for the prediction of hysteresis loop of electrical steel up to mean frequencies, taking into account the skin effect. In previous works, the analytical solution of the diffusion equation for low frequency (DELF) was coupled with the inverse static Jiles-Atherton (JA) model in order to represent the hysteresis behavior for a lamination. In the present paper, this approach is improved to ensure the reproducibility of measured hysteresis loops at mean frequency. The results of simulation are compared with the experimental ones. The selected results for frequencies 50 Hz, 100 Hz, 200 Hz and 400 Hz are presented and discussed.

  9. Unsteady panel method for complex configurations including wake modeling

    CSIR Research Space (South Africa)

    Van Zyl, Lourens H

    2008-01-01

    Full Text Available implementations of the DLM are however not very versatile in terms of geometries that can be modeled. The ZONA6 code offers a versatile surface panel body model including a separated wake model, but uses a pressure panel method for lifting surfaces. This paper...

  10. Modeling Electric Double-Layers Including Chemical Reaction Effects

    DEFF Research Database (Denmark)

    Paz-Garcia, Juan Manuel; Johannesson, Björn; Ottosen, Lisbeth M.

    2014-01-01

    A physicochemical and numerical model for the transient formation of an electric double-layer between an electrolyte and a chemically-active flat surface is presented, based on a finite elements integration of the nonlinear Nernst-Planck-Poisson model including chemical reactions. The model works...

  11. Circuit Modeling of a MEMS Varactor Including Dielectric Charging Dynamics

    Science.gov (United States)

    Giounanlis, P.; Andrade-Miceli, D.; Gorreta, S.; Pons-Nin, J.; Dominguez-Pumar, M.; Blokhina, E.

    2016-10-01

    Electrical models for MEMS varactors including the effect of dielectric charging dynamics are not available in commercial circuit simulators. In this paper a circuit model using lumped ideal elements available in the Cadence libraries and a basic Verilog-A model, has been implemented. The model has been used to simulate the dielectric charging in function of time and its effects over the MEMS capacitance value.

  12. Including investment risk in large-scale power market models

    DEFF Research Database (Denmark)

    Lemming, Jørgen Kjærgaard; Meibom, P.

    2003-01-01

    can be included in large-scale partial equilibrium models of the power market. The analyses are divided into a part about risk measures appropriate for power market investors and a more technical part about the combination of a risk-adjustment model and a partial-equilibrium model. To illustrate......Long-term energy market models can be used to examine investments in production technologies, however, with market liberalisation it is crucial that such models include investment risks and investor behaviour. This paper analyses how the effect of investment risk on production technology selection...... the analyses quantitatively, a framework based on an iterative interaction between the equilibrium model and a separate risk-adjustment module was constructed. To illustrate the features of the proposed modelling approach we examined how uncertainty in demand and variable costs affects the optimal choice...

  13. 36 CFR 1290.4 - Types of materials included in scope of assassination record and additional records and information.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Types of materials included in scope of assassination record and additional records and information. 1290.4 Section 1290.4 Parks... COLLECTION ACT OF 1992 (JFK ACT) § 1290.4 Types of materials included in scope of assassination record...

  14. Progressive IRP Models for Power Resources Including EPP

    Directory of Open Access Journals (Sweden)

    Yiping Zhu

    2017-01-01

    Full Text Available In the view of optimizing regional power supply and demand, the paper makes effective planning scheduling of supply and demand side resources including energy efficiency power plant (EPP, to achieve the target of benefit, cost, and environmental constraints. In order to highlight the characteristics of different supply and demand resources in economic, environmental, and carbon constraints, three planning models with progressive constraints are constructed. Results of three models by the same example show that the best solutions to different models are different. The planning model including EPP has obvious advantages considering pollutant and carbon emission constraints, which confirms the advantages of low cost and emissions of EPP. The construction of progressive IRP models for power resources considering EPP has a certain reference value for guiding the planning and layout of EPP within other power resources and achieving cost and environmental objectives.

  15. Model averaging for semiparametric additive partial linear models

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    To improve the prediction accuracy of semiparametric additive partial linear models(APLM) and the coverage probability of confidence intervals of the parameters of interest,we explore a focused information criterion for model selection among ALPM after we estimate the nonparametric functions by the polynomial spline smoothing,and introduce a general model average estimator.The major advantage of the proposed procedures is that iterative backfitting implementation is avoided,which thus results in gains in computational simplicity.The resulting estimators are shown to be asymptotically normal.A simulation study and a real data analysis are presented for illustrations.

  16. Modeling heart rate variability including the effect of sleep stages

    Science.gov (United States)

    Soliński, Mateusz; Gierałtowski, Jan; Żebrowski, Jan

    2016-02-01

    We propose a model for heart rate variability (HRV) of a healthy individual during sleep with the assumption that the heart rate variability is predominantly a random process. Autonomic nervous system activity has different properties during different sleep stages, and this affects many physiological systems including the cardiovascular system. Different properties of HRV can be observed during each particular sleep stage. We believe that taking into account the sleep architecture is crucial for modeling the human nighttime HRV. The stochastic model of HRV introduced by Kantelhardt et al. was used as the initial starting point. We studied the statistical properties of sleep in healthy adults, analyzing 30 polysomnographic recordings, which provided realistic information about sleep architecture. Next, we generated synthetic hypnograms and included them in the modeling of nighttime RR interval series. The results of standard HRV linear analysis and of nonlinear analysis (Shannon entropy, Poincaré plots, and multiscale multifractal analysis) show that—in comparison with real data—the HRV signals obtained from our model have very similar properties, in particular including the multifractal characteristics at different time scales. The model described in this paper is discussed in the context of normal sleep. However, its construction is such that it should allow to model heart rate variability in sleep disorders. This possibility is briefly discussed.

  17. A DNA based model for addition computation

    Institute of Scientific and Technical Information of China (English)

    GAO Lin; YANG Xiao; LIU Wenbin; XU Jin

    2004-01-01

    Much effort has been made to solve computing problems by using DNA-an organic simulating method, which in some cases is preferable to the current electronic computer. However, No one at present has proposed an effective and applicable method to solve addition problem with molecular algorithm due to the difficulty in solving the carry problem which can be easily solved by hardware of an electronic computer. In this article, we solved this problem by employing two kinds of DNA strings, one is called result and operation string while the other is named carrier. The result and operation string contains some carry information by its own and denotes the ultimate result while the carrier is just for carrying use. The significance of this algorithm is the original code, the fairly easy steps to follow and the feasibility under current molecular biological technology.

  18. High-dimensional additive hazard models and the Lasso

    CERN Document Server

    Gaïffas, Séphane

    2011-01-01

    We consider a general high-dimensional additive hazard model in a non-asymptotic setting, including regression for censored-data. In this context, we consider a Lasso estimator with a fully data-driven $\\ell_1$ penalization, which is tuned for the estimation problem at hand. We prove sharp oracle inequalities for this estimator. Our analysis involves a new "data-driven" Bernstein's inequality, that is of independent interest, where the predictable variation is replaced by the optional variation.

  19. A hydrodynamic model for granular material flows including segregation effects

    Science.gov (United States)

    Gilberg, Dominik; Klar, Axel; Steiner, Konrad

    2017-06-01

    The simulation of granular flows including segregation effects in large industrial processes using particle methods is accurate, but very time-consuming. To overcome the long computation times a macroscopic model is a natural choice. Therefore, we couple a mixture theory based segregation model to a hydrodynamic model of Navier-Stokes-type, describing the flow behavior of the granular material. The granular flow model is a hybrid model derived from kinetic theory and a soil mechanical approach to cover the regime of fast dilute flow, as well as slow dense flow, where the density of the granular material is close to the maximum packing density. Originally, the segregation model has been formulated by Thornton and Gray for idealized avalanches. It is modified and adapted to be in the preferred form for the coupling. In the final coupled model the segregation process depends on the local state of the granular system. On the other hand, the granular system changes as differently mixed regions of the granular material differ i.e. in the packing density. For the modeling process the focus lies on dry granular material flows of two particle types differing only in size but can be easily extended to arbitrary granular mixtures of different particle size and density. To solve the coupled system a finite volume approach is used. To test the model the rotational mixing of small and large particles in a tumbler is simulated.

  20. Synaptic channel model including effects of spike width variation

    OpenAIRE

    2015-01-01

    Synaptic Channel Model Including Effects of Spike Width Variation Hamideh Ramezani Next-generation and Wireless Communications Laboratory (NWCL) Department of Electrical and Electronics Engineering Koc University, Istanbul, Turkey Ozgur B. Akan Next-generation and Wireless Communications Laboratory (NWCL) Department of Electrical and Electronics Engineering Koc University, Istanbul, Turkey ABSTRACT An accu...

  1. A sonic boom propagation model including mean flow atmospheric effects

    Science.gov (United States)

    Salamone, Joe; Sparrow, Victor W.

    2012-09-01

    This paper presents a time domain formulation of nonlinear lossy propagation in onedimension that also includes the effects of non-collinear mean flow in the acoustic medium. The model equation utilized is an augmented Burgers equation that includes the effects of nonlinearity, geometric spreading, atmospheric stratification, and also absorption and dispersion due to thermoviscous and molecular relaxation effects. All elements of the propagation are implemented in the time domain and the effects of non-collinear mean flow are accounted for in each term of the model equation. Previous authors have presented methods limited to showing the effects of wind on ray tracing and/or using an effective speed of sound in their model equation. The present work includes the effects of mean flow for all terms included in the augmented Burgers equation with all of the calculations performed in the time-domain. The capability to include the effects of mean flow in the acoustic medium allows one to make predictions more representative of real-world atmospheric conditions. Examples are presented for nonlinear propagation of N-waves and shaped sonic booms. [Work supported by Gulfstream Aerospace Corporation.

  2. A Fault Evolution Model Including the Rupture Dynamic Simulation

    Science.gov (United States)

    Wu, Y.; Chen, X.

    2011-12-01

    We perform a preliminary numerical simulation of seismicity and stress evolution along a strike-slip fault in a 3D elastic half space. Following work of Ben-Zion (1996), the fault geometry is devised as a vertical plane which is about 70 km long and 17 km wide, comparable to the size of San Andreas Fault around Parkfield. The loading mechanism is described by "backslip" method. The fault failure is governed by a static/kinetic friction law, and induced stress transfer is calculated with Okada's static solution. In order to track the rupture propagation in detail, we allow induced stress to propagate through the medium at the shear wave velocity by introducing a distance-dependent time delay to responses to stress changes. Current simulation indicates small to moderate earthquakes following the Gutenberg-Richter law and quasi-periodical characteristic large earthquakes, which are consistent with previous work by others. Next we will consider introducing a more realistic friction law, namely, the laboratory-derived rate- and state- dependent law, which can simulate more realistic and complicated sliding behavior such as the stable and unstable slip, the aseismic sliding and the slip nucleation process. In addition, the long duration of aftershocks is expected to be reproduced due to this time-dependent friction law, which is not available in current seismicity simulation. The other difference from previous work is that we are trying to include the dynamic ruptures in this study. Most previous study on seismicity simulation is based on the static solution when dealing with failure induced stress changes. However, studies of numerical simulation of rupture dynamics have revealed lots of important details which are missing in the quasi-static/quasi- dynamic simulation. For example, dynamic simulations indicate that the slip on the ground surface becomes larger if the dynamic rupture process reaches the free surface. The concentration of stress on the propagating crack

  3. Major histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis

    Science.gov (United States)

    Wei, Wen-Hua; Bowes, John; Plant, Darren; Viatte, Sebastien; Yarwood, Annie; Massey, Jonathan; Worthington, Jane; Eyre, Stephen

    2016-01-01

    Genotypic variability based genome-wide association studies (vGWASs) can identify potentially interacting loci without prior knowledge of the interacting factors. We report a two-stage approach to make vGWAS applicable to diseases: firstly using a mixed model approach to partition dichotomous phenotypes into additive risk and non-additive environmental residuals on the liability scale and secondly using the Levene’s (Brown-Forsythe) test to assess equality of the residual variances across genotype groups per marker. We found widespread significant (P < 2.5e-05) vGWAS signals within the major histocompatibility complex (MHC) across all three study cohorts of rheumatoid arthritis. We further identified 10 epistatic interactions between the vGWAS signals independent of the MHC additive effects, each with a weak effect but jointly explained 1.9% of phenotypic variance. PTPN22 was also identified in the discovery cohort but replicated in only one independent cohort. Combining the three cohorts boosted power of vGWAS and additionally identified TYK2 and ANKRD55. Both PTPN22 and TYK2 had evidence of interactions reported elsewhere. We conclude that vGWAS can help discover interacting loci for complex diseases but require large samples to find additional signals. PMID:27109064

  4. Just Another Gibbs Additive Modeler: Interfacing JAGS and mgcv

    Directory of Open Access Journals (Sweden)

    Simon N. Wood

    2016-12-01

    Full Text Available The BUGS language offers a very flexible way of specifying complex statistical models for the purposes of Gibbs sampling, while its JAGS variant offers very convenient R integration via the rjags package. However, including smoothers in JAGS models can involve some quite tedious coding, especially for multivariate or adaptive smoothers. Further, if an additive smooth structure is required then some care is needed, in order to centre smooths appropriately, and to find appropriate starting values. R package mgcv implements a wide range of smoothers, all in a manner appropriate for inclusion in JAGS code, and automates centring and other smooth setup tasks. The purpose of this note is to describe an interface between mgcv and JAGS, based around an R function, jagam, which takes a generalized additive model (GAM as specified in mgcv and automatically generates the JAGS model code and data required for inference about the model via Gibbs sampling. Although the auto-generated JAGS code can be run as is, the expectation is that the user would wish to modify it in order to add complex stochastic model components readily specified in JAGS. A simple interface is also provided for visualisation and further inference about the estimated smooth components using standard mgcv functionality. The methods described here will be un-necessarily inefficient if all that is required is fully Bayesian inference about a standard GAM, rather than the full flexibility of JAGS. In that case the BayesX package would be more efficient.

  5. Goldilocks Models of Higher-Dimensional Inflation (including modulus stabilization)

    CERN Document Server

    Burgess, C P; Hayman, Peter; Patil, Subodh P

    2016-01-01

    We explore the mechanics of inflation in simplified extra-dimensional models involving an inflaton interacting with the Einstein-Maxwell system in two extra dimensions. The models are Goldilocks-like in that they are just complicated enough to include a mechanism to stabilize the extra-dimensional size, yet simple enough to solve the full 6D field equations using basic tools. The solutions are not limited to the effective 4D regime with H m_KK, but when they do standard 4D fluctuation calculations need not apply. When in a 4D regime the solutions predict eta ~ 0 hence n_s ~ 0.96 and r ~ 0.096 and so are ruled out if tensor modes remain unseen. Analysis of general parameters is difficult without a full 6D fluctuation calculation.

  6. Predicting the Probability of Lightning Occurrence with Generalized Additive Models

    Science.gov (United States)

    Fabsic, Peter; Mayr, Georg; Simon, Thorsten; Zeileis, Achim

    2017-04-01

    This study investigates the predictability of lightning in complex terrain. The main objective is to estimate the probability of lightning occurrence in the Alpine region during summertime afternoons (12-18 UTC) at a spatial resolution of 64 × 64 km2. Lightning observations are obtained from the ALDIS lightning detection network. The probability of lightning occurrence is estimated using generalized additive models (GAM). GAMs provide a flexible modelling framework to estimate the relationship between covariates and the observations. The covariates, besides spatial and temporal effects, include numerous meteorological fields from the ECMWF ensemble system. The optimal model is chosen based on a forward selection procedure with out-of-sample mean squared error as a performance criterion. Our investigation shows that convective precipitation and mid-layer stability are the most influential meteorological predictors. Both exhibit intuitive, non-linear trends: higher values of convective precipitation indicate higher probability of lightning, and large values of the mid-layer stability measure imply low lightning potential. The performance of the model was evaluated against a climatology model containing both spatial and temporal effects. Taking the climatology model as a reference forecast, our model attains a Brier Skill Score of approximately 46%. The model's performance can be further enhanced by incorporating the information about lightning activity from the previous time step, which yields a Brier Skill Score of 48%. These scores show that the method is able to extract valuable information from the ensemble to produce reliable spatial forecasts of the lightning potential in the Alps.

  7. Kinetic models of gene expression including non-coding RNAs

    Science.gov (United States)

    Zhdanov, Vladimir P.

    2011-03-01

    In cells, genes are transcribed into mRNAs, and the latter are translated into proteins. Due to the feedbacks between these processes, the kinetics of gene expression may be complex even in the simplest genetic networks. The corresponding models have already been reviewed in the literature. A new avenue in this field is related to the recognition that the conventional scenario of gene expression is fully applicable only to prokaryotes whose genomes consist of tightly packed protein-coding sequences. In eukaryotic cells, in contrast, such sequences are relatively rare, and the rest of the genome includes numerous transcript units representing non-coding RNAs (ncRNAs). During the past decade, it has become clear that such RNAs play a crucial role in gene expression and accordingly influence a multitude of cellular processes both in the normal state and during diseases. The numerous biological functions of ncRNAs are based primarily on their abilities to silence genes via pairing with a target mRNA and subsequently preventing its translation or facilitating degradation of the mRNA-ncRNA complex. Many other abilities of ncRNAs have been discovered as well. Our review is focused on the available kinetic models describing the mRNA, ncRNA and protein interplay. In particular, we systematically present the simplest models without kinetic feedbacks, models containing feedbacks and predicting bistability and oscillations in simple genetic networks, and models describing the effect of ncRNAs on complex genetic networks. Mathematically, the presentation is based primarily on temporal mean-field kinetic equations. The stochastic and spatio-temporal effects are also briefly discussed.

  8. Comparison of Joint Modeling Approaches Including Eulerian Sliding Interfaces

    Energy Technology Data Exchange (ETDEWEB)

    Lomov, I; Antoun, T; Vorobiev, O

    2009-12-16

    Accurate representation of discontinuities such as joints and faults is a key ingredient for high fidelity modeling of shock propagation in geologic media. The following study was done to improve treatment of discontinuities (joints) in the Eulerian hydrocode GEODYN (Lomov and Liu 2005). Lagrangian methods with conforming meshes and explicit inclusion of joints in the geologic model are well suited for such an analysis. Unfortunately, current meshing tools are unable to automatically generate adequate hexahedral meshes for large numbers of irregular polyhedra. Another concern is that joint stiffness in such explicit computations requires significantly reduced time steps, with negative implications for both the efficiency and quality of the numerical solution. An alternative approach is to use non-conforming meshes and embed joint information into regular computational elements. However, once slip displacement on the joints become comparable to the zone size, Lagrangian (even non-conforming) meshes could suffer from tangling and decreased time step problems. The use of non-conforming meshes in an Eulerian solver may alleviate these difficulties and provide a viable numerical approach for modeling the effects of faults on the dynamic response of geologic materials. We studied shock propagation in jointed/faulted media using a Lagrangian and two Eulerian approaches. To investigate the accuracy of this joint treatment the GEODYN calculations have been compared with results from the Lagrangian code GEODYN-L which uses an explicit treatment of joints via common plane contact. We explore two approaches to joint treatment in the code, one for joints with finite thickness and the other for tight joints. In all cases the sliding interfaces are tracked explicitly without homogenization or blending the joint and block response into an average response. In general, rock joints will introduce an increase in normal compliance in addition to a reduction in shear strength. In the

  9. Progress Towards an LES Wall Model Including Unresolved Roughness

    Science.gov (United States)

    Craft, Kyle; Redman, Andrew; Aikens, Kurt

    2015-11-01

    Wall models used in large eddy simulations (LES) are often based on theories for hydraulically smooth walls. While this is reasonable for many applications, there are also many where the impact of surface roughness is important. A previously developed wall model has been used primarily for jet engine aeroacoustics. However, jet simulations have not accurately captured thick initial shear layers found in some experimental data. This may partly be due to nozzle wall roughness used in the experiments to promote turbulent boundary layers. As a result, the wall model is extended to include the effects of unresolved wall roughness through appropriate alterations to the log-law. The methodology is tested for incompressible flat plate boundary layers with different surface roughness. Correct trends are noted for the impact of surface roughness on the velocity profile. However, velocity deficit profiles and the Reynolds stresses do not collapse as well as expected. Possible reasons for the discrepancies as well as future work will be presented. This work used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation grant number ACI-1053575. Computational resources on TACC Stampede were provided under XSEDE allocation ENG150001.

  10. Coordinate descent methods for the penalized semiparametric additive hazards model

    DEFF Research Database (Denmark)

    Gorst-Rasmussen, Anders; Scheike, Thomas

    . The semiparametric additive hazards model is a flexible alternative which is a natural survival analogue of the standard linear regression model. Building on this analogy, we develop a cyclic coordinate descent algorithm for fitting the lasso and elastic net penalized additive hazards model. The algorithm requires...

  11. Coordinate descent methods for the penalized semiprarametric additive hazard model

    DEFF Research Database (Denmark)

    Gorst-Rasmussen, Anders; Scheike, Thomas

    2012-01-01

    . The semiparametric additive hazards model is a flexible alternative which is a natural survival analogue of the standard linear regression model. Building on this analogy, we develop a cyclic coordinate descent algorithm for fitting the lasso and elastic net penalized additive hazards model. The algorithm requires...

  12. Further Results on Dynamic Additive Hazard Rate Model

    Directory of Open Access Journals (Sweden)

    Zhengcheng Zhang

    2014-01-01

    Full Text Available In the past, the proportional and additive hazard rate models have been investigated in the works. Nanda and Das (2011 introduced and studied the dynamic proportional (reversed hazard rate model. In this paper we study the dynamic additive hazard rate model, and investigate its aging properties for different aging classes. The closure of the model under some stochastic orders has also been investigated. Some examples are also given to illustrate different aging properties and stochastic comparisons of the model.

  13. Human sperm chromatin stabilization: a proposed model including zinc bridges.

    Science.gov (United States)

    Björndahl, Lars; Kvist, Ulrik

    2010-01-01

    The primary focus of this review is to challenge the current concepts on sperm chromatin stability. The observations (i) that zinc depletion at ejaculation allows a rapid and total sperm chromatin decondensation without the addition of exogenous disulfide cleaving agents and (ii) that the human sperm chromatin contains one zinc for every protamine for every turn of the DNA helix suggest an alternative model for sperm chromatin structure may be plausible. An alternative model is therefore proposed, that the human spermatozoon could at ejaculation have a rapidly reversible zinc dependent chromatin stability: Zn(2+) stabilizes the structure and prevents the formation of excess disulfide bridges by a single mechanism, the formation of zinc bridges with protamine thiols of cysteine and potentially imidazole groups of histidine. Extraction of zinc enables two biologically totally different outcomes: immediate decondensation if chromatin fibers are concomitantly induced to repel (e.g. by phosphorylation in the ooplasm); otherwise freed thiols become committed into disulfide bridges creating a superstabilized chromatin. Spermatozoa in the zinc rich prostatic fluid (normally the first expelled ejaculate fraction) represent the physiological situation. Extraction of chromatin zinc can be accomplished by the seminal vesicular fluid. Collection of the ejaculate in one single container causes abnormal contact between spermatozoa and seminal vesicular fluid affecting the sperm chromatin stability. There are men in infertile couples with low content of sperm chromatin zinc due to loss of zinc during ejaculation and liquefaction. Tests for sperm DNA integrity may give false negative results due to decreased access for the assay to the DNA in superstabilized chromatin.

  14. WATEQ3 geochemical model: thermodynamic data for several additional solids

    Energy Technology Data Exchange (ETDEWEB)

    Krupka, K.M.; Jenne, E.A.

    1982-09-01

    Geochemical models such as WATEQ3 can be used to model the concentrations of water-soluble pollutants that may result from the disposal of nuclear waste and retorted oil shale. However, for a model to competently deal with these water-soluble pollutants, an adequate thermodynamic data base must be provided that includes elements identified as important in modeling these pollutants. To this end, several minerals and related solid phases were identified that were absent from the thermodynamic data base of WATEQ3. In this study, the thermodynamic data for the identified solids were compiled and selected from several published tabulations of thermodynamic data. For these solids, an accepted Gibbs free energy of formation, ..delta..G/sup 0//sub f,298/, was selected for each solid phase based on the recentness of the tabulated data and on considerations of internal consistency with respect to both the published tabulations and the existing data in WATEQ3. For those solids not included in these published tabulations, Gibbs free energies of formation were calculated from published solubility data (e.g., lepidocrocite), or were estimated (e.g., nontronite) using a free-energy summation method described by Mattigod and Sposito (1978). The accepted or estimated free energies were then combined with internally consistent, ancillary thermodynamic data to calculate equilibrium constants for the hydrolysis reactions of these minerals and related solid phases. Including these values in the WATEQ3 data base increased the competency of this geochemical model in applications associated with the disposal of nuclear waste and retorted oil shale. Additional minerals and related solid phases that need to be added to the solubility submodel will be identified as modeling applications continue in these two programs.

  15. Goldilocks models of higher-dimensional inflation (including modulus stabilization)

    Science.gov (United States)

    Burgess, C. P.; Enns, Jared J. H.; Hayman, Peter; Patil, Subodh P.

    2016-08-01

    We explore the mechanics of inflation within simplified extra-dimensional models involving an inflaton interacting with the Einstein-Maxwell system in two extra dimensions. The models are Goldilocks-like inasmuch as they are just complicated enough to include a mechanism to stabilize the extra-dimensional size (or modulus), yet simple enough to solve explicitly the full extra-dimensional field equations using only simple tools. The solutions are not restricted to the effective 4D regime with H ll mKK (the latter referring to the characteristic mass splitting of the Kaluza-Klein excitations) because the full extra-dimensional Einstein equations are solved. This allows an exploration of inflationary physics in a controlled calculational regime away from the usual four-dimensional lamp-post. The inclusion of modulus stabilization is important because experience with string models teaches that this is usually what makes models fail: stabilization energies easily dominate the shallow potentials required by slow roll and so open up directions to evolve that are steeper than those of the putative inflationary direction. We explore (numerically and analytically) three representative kinds of inflationary scenarios within this simple setup. In one the radion is trapped in an inflaton-dependent local minimum whose non-zero energy drives inflation. Inflation ends as this energy relaxes to zero when the inflaton finds its own minimum. The other two involve power-law scaling solutions during inflation. One of these is a dynamical attractor whose features are relatively insensitive to initial conditions but whose slow-roll parameters cannot be arbitrarily small; the other is not an attractor but can roll much more slowly, until eventually transitioning to the attractor. The scaling solutions can satisfy H > mKK, but when they do standard 4D fluctuation calculations need not apply. When in a 4D regime the solutions predict η simeq 0 and so r simeq 0.11 when ns simeq 0.96 and so

  16. Multiscale and Multiphysics Modeling of Additive Manufacturing of Advanced Materials

    Science.gov (United States)

    Liou, Frank; Newkirk, Joseph; Fan, Zhiqiang; Sparks, Todd; Chen, Xueyang; Fletcher, Kenneth; Zhang, Jingwei; Zhang, Yunlu; Kumar, Kannan Suresh; Karnati, Sreekar

    2015-01-01

    The objective of this proposed project is to research and develop a prediction tool for advanced additive manufacturing (AAM) processes for advanced materials and develop experimental methods to provide fundamental properties and establish validation data. Aircraft structures and engines demand materials that are stronger, useable at much higher temperatures, provide less acoustic transmission, and enable more aeroelastic tailoring than those currently used. Significant improvements in properties can only be achieved by processing the materials under nonequilibrium conditions, such as AAM processes. AAM processes encompass a class of processes that use a focused heat source to create a melt pool on a substrate. Examples include Electron Beam Freeform Fabrication and Direct Metal Deposition. These types of additive processes enable fabrication of parts directly from CAD drawings. To achieve the desired material properties and geometries of the final structure, assessing the impact of process parameters and predicting optimized conditions with numerical modeling as an effective prediction tool is necessary. The targets for the processing are multiple and at different spatial scales, and the physical phenomena associated occur in multiphysics and multiscale. In this project, the research work has been developed to model AAM processes in a multiscale and multiphysics approach. A macroscale model was developed to investigate the residual stresses and distortion in AAM processes. A sequentially coupled, thermomechanical, finite element model was developed and validated experimentally. The results showed the temperature distribution, residual stress, and deformation within the formed deposits and substrates. A mesoscale model was developed to include heat transfer, phase change with mushy zone, incompressible free surface flow, solute redistribution, and surface tension. Because of excessive computing time needed, a parallel computing approach was also tested. In addition

  17. Apology in the criminal justice setting: evidence for including apology as an additional component in the legal system.

    Science.gov (United States)

    Petrucci, Carrie J

    2002-01-01

    The criminal justice system has reached unprecedented scope in the United States, with over 6.4 million people under some type of supervision. Remedies that have the potential to reduce this number are continually being sought. This article analyzes an innovative strategy currently being reconsidered in criminal justice: the apology. Despite a legal system that only sporadically acknowledges it, evidence for the use of apology is supported by social science research, current criminal justice theories, case law, and empirical studies. Social psychological, sociological and socio-legal studies pinpoint the elements and function of apology, what makes apologies effective, and concerns about apology if it were implemented in the criminal justice system. Theoretical evidence is examined (including restorative justice, therapeutic jurisprudence, crime, shame, and reintegration) to explore the process of apology in the criminal justice context. Attribution theory and social conduct theory are used to explain the apology process specifically for victims and offenders. A brief examination of case law reveals that though apology has no formal place in criminal law, it has surfaced recently under the federal sentencing guidelines. Finally, empirical evidence in criminal justice settings reveals that offenders want to apologize and victims desire an apology. Moreover, by directly addressing the harmful act, apology may be the link to reduced recidivism for offenders, as well as empowerment for victims. This evidence combined suggests that apology is worthy of further study as a potentially valuable addition to the criminal justice process. Copyright 2002 John Wiley & Sons, Ltd.

  18. Including spatial data in nutrient balance modelling on dairy farms

    Science.gov (United States)

    van Leeuwen, Maricke; van Middelaar, Corina; Stoof, Cathelijne; Oenema, Jouke; Stoorvogel, Jetse; de Boer, Imke

    2017-04-01

    The Annual Nutrient Cycle Assessment (ANCA) calculates the nitrogen (N) and phosphorus (P) balance at a dairy farm, while taking into account the subsequent nutrient cycles of the herd, manure, soil and crop components. Since January 2016, Dutch dairy farmers are required to use ANCA in order to increase understanding of nutrient flows and to minimize nutrient losses to the environment. A nutrient balance calculates the difference between nutrient inputs and outputs. Nutrients enter the farm via purchased feed, fertilizers, deposition and fixation by legumes (nitrogen), and leave the farm via milk, livestock, manure, and roughages. A positive balance indicates to which extent N and/or P are lost to the environment via gaseous emissions (N), leaching, run-off and accumulation in soil. A negative balance indicates that N and/or P are depleted from soil. ANCA was designed to calculate average nutrient flows on farm level (for the herd, manure, soil and crop components). ANCA was not designed to perform calculations of nutrient flows at the field level, as it uses averaged nutrient inputs and outputs across all fields, and it does not include field specific soil characteristics. Land management decisions, however, such as the level of N and P application, are typically taken at the field level given the specific crop and soil characteristics. Therefore the information that ANCA provides is likely not sufficient to support farmers' decisions on land management to minimize nutrient losses to the environment. This is particularly a problem when land management and soils vary between fields. For an accurate estimate of nutrient flows in a given farming system that can be used to optimize land management, the spatial scale of nutrient inputs and outputs (and thus the effect of land management and soil variation) could be essential. Our aim was to determine the effect of the spatial scale of nutrient inputs and outputs on modelled nutrient flows and nutrient use efficiencies

  19. A Discrete Velocity Traffic Kinetic Model Including Desired Speed

    Directory of Open Access Journals (Sweden)

    Shoufeng Lu

    2013-05-01

    Full Text Available We introduce the desired speed variable into the table of games and formulate a new table of games and the corresponding discrete traffic kinetic model. We use the hybrid programming technique of VB and MATLAB to develop the program. Lastly, we compared the proposed model result and the detector data. The results show that the proposed model can describe the traffic flow evolution.

  20. Semi-holographic model including the radiation component

    CERN Document Server

    del Campo, Sergio; Magaña, Juan; Villanueva, J R

    2014-01-01

    In this letter we study the semi holographic model which corresponds to the radiative version of the model proposed by Zhang et al. (Phys. Lett. B 694 (2010), 177) and revisited by C\\'ardenas et al. (Mon. Not. Roy. Astron. Soc. 438 (2014), 3603). This inclusion makes the model more realistic, so allows us to test it with current observational data and then answer if the inconsistency reported by C\\'ardenas et al. is relaxed.

  1. [Critical of the additive model of the randomized controlled trial].

    Science.gov (United States)

    Boussageon, Rémy; Gueyffier, François; Bejan-Angoulvant, Theodora; Felden-Dominiak, Géraldine

    2008-01-01

    Randomized, double-blind, placebo-controlled clinical trials are currently the best way to demonstrate the clinical effectiveness of drugs. Its methodology relies on the method of difference (John Stuart Mill), through which the observed difference between two groups (drug vs placebo) can be attributed to the pharmacological effect of the drug being tested. However, this additive model can be questioned in the event of statistical interactions between the pharmacological and the placebo effects. Evidence in different domains has shown that the placebo effect can influence the effect of the active principle. This article evaluates the methodological, clinical and epistemological consequences of this phenomenon. Topics treated include extrapolating results, accounting for heterogeneous results, demonstrating the existence of several factors in the placebo effect, the necessity to take these factors into account for given symptoms or pathologies, as well as the problem of the "specific" effect.

  2. Evacuation modeling including traveler information and compliance behavior

    NARCIS (Netherlands)

    Pel, A.J.; Hoogendoorn, S.P.; Bliemer, M.C.J.

    2010-01-01

    Traffic simulation models are often used to support decisions when planning an evacuation. Scenario analyses based on these models then typically focus on traffic dynamics and the effect of traffic control measures in order to locate possible bottlenecks and predict evacuation times. A clear approac

  3. Global atmospheric model for mercury including oxidation by bromine atoms

    Directory of Open Access Journals (Sweden)

    C. D. Holmes

    2010-12-01

    Full Text Available Global models of atmospheric mercury generally assume that gas-phase OH and ozone are the main oxidants converting Hg0 to HgII and thus driving mercury deposition to ecosystems. However, thermodynamic considerations argue against the importance of these reactions. We demonstrate here the viability of atomic bromine (Br as an alternative Hg0 oxidant. We conduct a global 3-D simulation with the GEOS-Chem model assuming gas-phase Br to be the sole Hg0 oxidant (Hg + Br model and compare to the previous version of the model with OH and ozone as the sole oxidants (Hg + OH/O3 model. We specify global 3-D Br concentration fields based on our best understanding of tropospheric and stratospheric Br chemistry. In both the Hg + Br and Hg + OH/O3 models, we add an aqueous photochemical reduction of HgII in cloud to impose a tropospheric lifetime for mercury of 6.5 months against deposition, as needed to reconcile observed total gaseous mercury (TGM concentrations with current estimates of anthropogenic emissions. This added reduction would not be necessary in the Hg + Br model if we adjusted the Br oxidation kinetics downward within their range of uncertainty. We find that the Hg + Br and Hg + OH/O3 models are equally capable of reproducing the spatial distribution of TGM and its seasonal cycle at northern mid-latitudes. The Hg + Br model shows a steeper decline of TGM concentrations from the tropics to southern mid-latitudes. Only the Hg + Br model can reproduce the springtime depletion and summer rebound of TGM observed at polar sites; the snowpack component of GEOS-Chem suggests that 40% of HgII deposited to snow in the Arctic is transferred to the ocean and land reservoirs, amounting to a net deposition flux to the Arctic of 60 Mg a−1. Summertime events of depleted Hg0 at Antarctic sites due to subsidence are much better simulated by

  4. Pilot Wave model that includes creation and annihilation of particles

    CERN Document Server

    Sverdlov, Roman

    2010-01-01

    The purpose of this paper is to come up with a Pilot Wave model of quantum field theory that incorporates particle creation and annihilation without sacrificing determinism. This has been previously attempted in an article by the same author titled "Incorporating particle creation and annihilation in Pilot Wave model", in a much less satisfactory way. In this paper I would like to "clean up" some of the things. In particular, I would like to get rid of a very unnatural concept of "visibility" of particles, which makes the model much simpler. On the other hand, I would like to add a mechanism for decoherence, which was absent in the previous version.

  5. Global atmospheric model for mercury including oxidation by bromine atoms

    Directory of Open Access Journals (Sweden)

    C. D. Holmes

    2010-08-01

    Full Text Available Global models of atmospheric mercury generally assume that OH and ozone are the main oxidants converting Hg0 to HgII and thus driving mercury deposition to ecosystems. However, thermodynamic considerations argue against the importance of these reactions. We demonstrate here the viability of atomic bromine (Br as an alternative Hg0 oxidant. We conduct a global 3-D simulation with the GEOS-Chem model assuming Br to be the sole Hg0 oxidant (Hg + Br model and compare to the previous version of the model with OH and ozone as the sole oxidants (Hg + OH/O3 model. We specify global 3-D Br concentration fields based on our best understanding of tropospheric and stratospheric Br chemistry. In both the Hg + Br and Hg + OH/O3 models, we add an aqueous photochemical reduction of HgII in cloud to impose a tropospheric lifetime for mercury of 6.5 months against deposition, as needed to reconcile observed total gaseous mercury (TGM concentrations with current estimates of anthropogenic emissions. This added reduction would not be necessary in the Hg + Br model if we adjusted the Br oxidation kinetics downward within their range of uncertainty. We find that the Hg + Br and Hg + OH/O3 models are equally capable of reproducing the spatial distribution of TGM and its seasonal cycle at northern mid-latitudes. The Hg + Br model shows a steeper decline of TGM concentrations from the tropics to southern mid-latitudes. Only the Hg + Br model can reproduce the springtime depletion and summer rebound of TGM observed at polar sites; the snowpack component of GEOS-Chem suggests that 40% of HgII deposited to snow in the Arctic is transferred to the ocean and land reservoirs, amounting to a net deposition flux of 60 Mg a−1. Summertime events of depleted Hg0 at Antarctic sites due to subsidence are much better simulated by the Hg + Br model. Model

  6. An Intracellular Calcium Oscillations Model Including Mitochondrial Calcium Cycling

    Institute of Scientific and Technical Information of China (English)

    SHI Xiao-Min; LIU Zeng-Rong

    2005-01-01

    @@ Calcium is a ubiquitous second messenger. Mitochondria contributes significantly to intracellular Ca2+ dynamics.The experiment of Kaftan et al. [J. Biol. Chem. 275(2000) 25465] demonstrated that inhibiting mitochondrial Ca2+ uptake can reduce the frequency of cytosolic Ca2+ concentration oscillations of gonadotropes. By considering the mitochondrial Ca2+ cycling we develop a three-variable model of intracellular Ca2+ oscillations based on the models of Atri et al. [Biophys. J. 65 (1993) 1727] and Falcke et al. [Biophys. J. 77 (1999) 37]. The model reproduces the fact that mitochondrial Ca2+ cycling increases the frequency of cytosolic Ca2+ oscillations, which accords with Kaftan's results. Moreover the model predicts that when the mitochondria overload with Ca2+, the cytosolic Ca2+ oscillations vanish, which may trigger apoptosis.

  7. Coordinate descent methods for the penalized semiprarametric additive hazard model

    DEFF Research Database (Denmark)

    Gorst-Rasmussen, Anders; Scheike, Thomas

    2012-01-01

    For survival data with a large number of explanatory variables, lasso penalized Cox regression is a popular regularization strategy. However, a penalized Cox model may not always provide the best fit to data and can be difficult to estimate in high dimension because of its intrinsic nonlinearity....... The semiparametric additive hazards model is a flexible alternative which is a natural survival analogue of the standard linear regression model. Building on this analogy, we develop a cyclic coordinate descent algorithm for fitting the lasso and elastic net penalized additive hazards model. The algorithm requires...

  8. A general additive-multiplicative rates model for recurrent event data

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    In this article, we propose a general additive-multiplicative rates model for recurrent event data. The proposed model includes the additive rates and multiplicative rates models as special cases. For the inference on the model parameters, estimating equation approaches are developed, and asymptotic properties of the proposed estimators are established through modern empirical process theory. In addition, an illustration with multiple-infection data from a clinic study on chronic granulomatous disease is provided.

  9. Geo-additive modelling of malaria in Burundi

    Directory of Open Access Journals (Sweden)

    Gebhardt Albrecht

    2011-08-01

    Full Text Available Abstract Background Malaria is a major public health issue in Burundi in terms of both morbidity and mortality, with around 2.5 million clinical cases and more than 15,000 deaths each year. It is still the single main cause of mortality in pregnant women and children below five years of age. Because of the severe health and economic burden of malaria, there is still a growing need for methods that will help to understand the influencing factors. Several studies/researches have been done on the subject yielding different results as which factors are most responsible for the increase in malaria transmission. This paper considers the modelling of the dependence of malaria cases on spatial determinants and climatic covariates including rainfall, temperature and humidity in Burundi. Methods The analysis carried out in this work exploits real monthly data collected in the area of Burundi over 12 years (1996-2007. Semi-parametric regression models are used. The spatial analysis is based on a geo-additive model using provinces as the geographic units of study. The spatial effect is split into structured (correlated and unstructured (uncorrelated components. Inference is fully Bayesian and uses Markov chain Monte Carlo techniques. The effects of the continuous covariates are modelled by cubic p-splines with 20 equidistant knots and second order random walk penalty. For the spatially correlated effect, Markov random field prior is chosen. The spatially uncorrelated effects are assumed to be i.i.d. Gaussian. The effects of climatic covariates and the effects of other spatial determinants are estimated simultaneously in a unified regression framework. Results The results obtained from the proposed model suggest that although malaria incidence in a given month is strongly positively associated with the minimum temperature of the previous months, regional patterns of malaria that are related to factors other than climatic variables have been identified

  10. An Additive-Multiplicative Restricted Mean Residual Life Model

    DEFF Research Database (Denmark)

    Mansourvar, Zahra; Martinussen, Torben; Scheike, Thomas H.

    2016-01-01

    mean residual life model to study the association between the restricted mean residual life function and potential regression covariates in the presence of right censoring. This model extends the proportional mean residual life model using an additive model as its covariate dependent baseline....... For the suggested model, some covariate effects are allowed to be time-varying. To estimate the model parameters, martingale estimating equations are developed, and the large sample properties of the resulting estimators are established. In addition, to assess the adequacy of the model, we investigate a goodness...... of fit test that is asymptotically justified. The proposed methodology is evaluated via simulation studies and further applied to a kidney cancer data set collected from a clinical trial....

  11. Cement-aggregate compatibility and structure property relationships including modelling

    Energy Technology Data Exchange (ETDEWEB)

    Jennings, H.M.; Xi, Y.

    1993-07-15

    The role of aggregate, and its interface with cement paste, is discussed with a view toward establishing models that relate structure to properties. Both short (nm) and long (mm) range structure must be considered. The short range structure of the interface depends not only on the physical distribution of the various phases, but also on moisture content and reactivity of aggregate. Changes that occur on drying, i.e. shrinkage, may alter the structure which, in turn, feeds back to alter further drying and shrinkage. The interaction is dynamic, even without further hydration of cement paste, and the dynamic characteristic must be considered in order to fully understand and model its contribution to properties. Microstructure and properties are two subjects which have been pursued somewhat separately. This review discusses both disciplines with a view toward finding common research goals in the future. Finally, comment is made on possible chemical reactions which may occur between aggregate and cement paste.

  12. Comprehensive European dietary exposure model (CEDEM) for food additives.

    Science.gov (United States)

    Tennant, David R

    2016-05-01

    European methods for assessing dietary exposures to nutrients, additives and other substances in food are limited by the availability of detailed food consumption data for all member states. A proposed comprehensive European dietary exposure model (CEDEM) applies summary data published by the European Food Safety Authority (EFSA) in a deterministic model based on an algorithm from the EFSA intake method for food additives. The proposed approach can predict estimates of food additive exposure provided in previous EFSA scientific opinions that were based on the full European food consumption database.

  13. Including lateral interactions into microkinetic models of catalytic reactions

    DEFF Research Database (Denmark)

    Hellman, Anders; Honkala, Johanna Karoliina

    2007-01-01

    In many catalytic reactions lateral interactions between adsorbates are believed to have a strong influence on the reaction rates. We apply a microkinetic model to explore the effect of lateral interactions and how to efficiently take them into account in a simple catalytic reaction. Three differ...... different approximations are investigated: site, mean-field, and quasichemical approximations. The obtained results are compared to accurate Monte Carlo numbers. In the end, we apply the approximations to a real catalytic reaction, namely, ammonia synthesis....

  14. 77 FR 1073 - Privacy Act of 1974; Report of an Altered System of Records, Including Addition of Routine Uses...

    Science.gov (United States)

    2012-01-09

    ... specifics). Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, (refer to http... are: Section 505(i) of the Federal Food, Drug, and Cosmetic Act (FD&C Act) (21 U.S.C. 355(i)(3)), 21... Food Safety and Applied Nutrition (refer to http://www.fda.gov for address specifics). Office...

  15. Controlled Carbon Source Addition to an Alternating Nitrification-Denitrification Wastewater Treatment Process Including Biological P Removal

    DEFF Research Database (Denmark)

    Isaacs, Steven Howard; Henze, Mogens

    1995-01-01

    experiments performed in 5 liter bottles indicated that the denitrification rate can be instantaneously increased through the addition of either carbon source. The amount by which the rate was increased depended on the amount of carbon added. In the main experiments performed in a pilot scale alternating...

  16. Additive Intensity Regression Models in Corporate Default Analysis

    DEFF Research Database (Denmark)

    Lando, David; Medhat, Mamdouh; Nielsen, Mads Stenbo

    2013-01-01

    We consider additive intensity (Aalen) models as an alternative to the multiplicative intensity (Cox) models for analyzing the default risk of a sample of rated, nonfinancial U.S. firms. The setting allows for estimating and testing the significance of time-varying effects. We use a variety of mo...

  17. Neighboring extremal optimal control design including model mismatch errors

    Energy Technology Data Exchange (ETDEWEB)

    Kim, T.J. [Sandia National Labs., Albuquerque, NM (United States); Hull, D.G. [Texas Univ., Austin, TX (United States). Dept. of Aerospace Engineering and Engineering Mechanics

    1994-11-01

    The mismatch control technique that is used to simplify model equations of motion in order to determine analytic optimal control laws is extended using neighboring extremal theory. The first variation optimal control equations are linearized about the extremal path to account for perturbations in the initial state and the final constraint manifold. A numerical example demonstrates that the tuning procedure inherent in the mismatch control method increases the performance of the controls to the level of a numerically-determined piecewise-linear controller.

  18. Double pendulum model for tennis stroke including a collision process

    CERN Document Server

    Youn, Sun-Hyun

    2015-01-01

    By means of adding a collision process between the ball and racket in double pendulum model, we analyzed the tennis stroke. It is possible that the speed of the rebound ball does not simply depend on the angular velocity of the racket, and higher angular velocity sometimes gives lower ball speed. We numerically showed that the proper time lagged racket rotation increases the speed of the rebound ball by 20%. We also showed that the elbow should move in order to add the angular velocity of the racket.

  19. Modelling of Dual-Junction Solar Cells including Tunnel Junction

    Directory of Open Access Journals (Sweden)

    Abdelaziz Amine

    2013-01-01

    Full Text Available Monolithically stacked multijunction solar cells based on III–V semiconductors materials are the state-of-art of approach for high efficiency photovoltaic energy conversion, in particular for space applications. The individual subcells of the multi-junction structure are interconnected via tunnel diodes which must be optically transparent and connect the component cells with a minimum electrical resistance. The quality of these diodes determines the output performance of the solar cell. The purpose of this work is to contribute to the investigation of the tunnel electrical resistance of such a multi-junction cell through the analysis of the current-voltage (J-V characteristics under illumination. Our approach is based on an equivalent circuit model of a diode for each subcell. We examine the effect of tunnel resistance on the performance of a multi-junction cell using minimization of the least squares technique.

  20. Global model including multistep ionizations in helium plasmas

    Science.gov (United States)

    Oh, Seung-Ju; Lee, Hyo-Chang; Chung, Chin-Wook

    2016-12-01

    Particle and power balance equations including stepwise ionizations are derived and solved in helium plasmas. In the balance equations, two metastable states (21S1 in singlet and 23S1 triplet) are considered and the followings are obtained. The plasma density linearly increases and the electron temperature is relatively in a constant value against the absorbed power. It is also found that the contribution to multi-step ionization with respect to the single-step ionization is in the range of 8%-23%, as the gas pressure increases from 10 mTorr to 100 mTorr. Compared to the results in the argon plasma, there is little variation in the collisional energy loss per electron-ion pair created (ɛc) with absorbed power and gas pressure due to the small collision cross section and higher inelastic collision threshold energy.

  1. Modelization of a water tank including a PCM module

    Energy Technology Data Exchange (ETDEWEB)

    Ibanez, Manuel [Dept. de Medi Ambient i Ciencies del Sol, Universitat de Lleida, Rovira Roure 191, 25198 Lleida (Spain); Cabeza, Luisa F.; Sole, Cristian; Roca, Joan; Nogues, Miquel [Dept. d' Informatica i Eng. Industrial, Universitat de Lleida, Jaume II 69, 25001 Lleida (Spain)

    2006-08-15

    The reduction of CO{sub 2} emissions is a key component for today's governments. Therefore, implementation of more and more systems with renewable energies is necessary. Solar systems for single family houses or residential buildings need a big water tank that many times is not easy to locate. This paper studies the modelization of a new technology where PCM modules are implemented in domestic hot water tanks to reduce their size without reducing the energy stored. A new TRNSYS component, based in the already existing TYPE 60, was developed, called TYPE 60PCM. After tuning the new component with experimental results, two more experiences were developed to validate the simulation of a water tank with two cylindrical PCM modules using type 60PCM, the cooldown and reheating experiments. Concordance between experimental and simulated data was very good. Since the new TRNSYS component was developed to simulate full solar systems, comparison of experimental results from a pilot plant solar system with simulations were performed, and they confirmed that the type 60PCM is a powerful tool to evaluate the performance of PCM modules in water tanks. (author)

  2. Method for assessment of stormwater treatment facilities – Synthetic road runoff addition including micro-pollutants and tracer

    DEFF Research Database (Denmark)

    Cederkvist, Karin; Jensen, Marina Bergen; Holm, Peter Engelund

    2017-01-01

    representative of runoff from roads is suggested, as well as relevant concentration ranges. The method was used for adding contaminants to three different STFs including a curbstone extension with filter soil, a dual porosity filter, and six different permeable pavements. Evaluation of the method showed......% in the dual porosity filter, stressing the importance of including a conservative tracer for correction of contaminant retention values. The method is considered useful in future treatment performance testing of STFs. The observed performance of the STFs is presented in coming papers....

  3. 78 FR 67369 - National Vaccine Injury Compensation Program: Addition to the Vaccine Injury Table to Include All...

    Science.gov (United States)

    2013-11-12

    ... by covered childhood vaccines. Prior to this publication, trivalent influenza vaccines were included... the Table specifies that `` ny new vaccine recommended by CDC for routine administration to children... Weekly Report (MMWR) that influenza vaccines be routinely administered to children between 6 and...

  4. Using Set Model for Learning Addition of Integers

    Directory of Open Access Journals (Sweden)

    Umi Puji Lestari

    2015-07-01

    Full Text Available This study aims to investigate how set model can help students' understanding of addition of integers in fourth grade. The study has been carried out to 23 students and a teacher of IVC SD Iba Palembang in January 2015. This study is a design research that also promotes PMRI as the underlying design context and activity. Results showed that the use of set models that is packaged in activity of recording of financial transactions in two color chips and card game can help students to understand the concept of zero pair, addition with the same colored chips, and cancellation strategy.

  5. Process chain modeling and selection in an additive manufacturing context

    DEFF Research Database (Denmark)

    Thompson, Mary Kathryn; Stolfi, Alessandro; Mischkot, Michael

    2016-01-01

    can compete with traditional process chains for small production runs. Combining both types of technology added cost but no benefit in this case. The new process chain model can be used to explain the results and support process selection, but process chain prototyping is still important for rapidly......This paper introduces a new two-dimensional approach to modeling manufacturing process chains. This approach is used to consider the role of additive manufacturing technologies in process chains for a part with micro scale features and no internal geometry. It is shown that additive manufacturing...

  6. Electroacoustics modeling of piezoelectric welders for ultrasonic additive manufacturing processes

    Science.gov (United States)

    Hehr, Adam; Dapino, Marcelo J.

    2016-04-01

    Ultrasonic additive manufacturing (UAM) is a recent 3D metal printing technology which utilizes ultrasonic vibrations from high power piezoelectric transducers to additively weld similar and dissimilar metal foils. CNC machining is used intermittent of welding to create internal channels, embed temperature sensitive components, sensors, and materials, and for net shaping parts. Structural dynamics of the welder and work piece influence the performance of the welder and part quality. To understand the impact of structural dynamics on UAM, a linear time-invariant model is used to relate system shear force and electric current inputs to the system outputs of welder velocity and voltage. Frequency response measurements are combined with in-situ operating measurements of the welder to identify model parameters and to verify model assumptions. The proposed LTI model can enhance process consistency, performance, and guide the development of improved quality monitoring and control strategies.

  7. Uranium hydrogeochemical and stream sediment reconnaissance of the Arminto NTMS quadrangle, Wyoming, including concentrations of forty-three additional elements

    Energy Technology Data Exchange (ETDEWEB)

    Morgan, T.L.

    1979-11-01

    During the summers of 1976 and 1977, 570 water and 1249 sediment samples were collected from 1517 locations within the 18,000-km/sup 2/ area of the Arminto NTMS quadrangle of central Wyoming. Water samples were collected from wells, springs, streams, and artifical ponds; sediment samples were collected from wet and dry streams, springs, and wet and dry ponds. All water samples were analyzed for 13 elements, including uranium, and each sediment sample was analyzed for 43 elements, including uranium and thorium. Uranium concentrations in water samples range from below the detection limit to 84.60 parts per billion (ppb) with a mean of 4.32 ppb. All water sample types except pond water samples were considered as a single population in interpreting the data. Pond water samples were excluded due to possible concentration of uranium by evaporation. Most of the water samples containing greater than 20 ppb uranium grouped into six clusters that indicate possible areas of interest for further investigation. One cluster is associated with the Pumpkin Buttes District, and two others are near the Kaycee and Mayoworth areas of uranium mineralization. The largest cluster is located on the west side of the Powder River Basin. One cluster is located in the central Big Horn Basin and another is in the Wind River Basin; both are in areas underlain by favorable host units. Uranium concentrations in sediment samples range from 0.08 parts per million (ppm) to 115.50 ppm with a mean of 3.50 ppm. Two clusters of sediment samples over 7 ppm were delineated. The first, containing the two highest-concentration samples, corresponds with the Copper Mountain District. Many of the high uranium concentrations in samples in this cluster may be due to contamination from mining or prospecting activity upstream from the sample sites. The second cluster encompasses a wide area in the Wind River Basin along the southern boundary of the quadrangle.

  8. Performance of portland limestone cements: Cements designed to be more sustainable that include up to 15% limestone addition

    Science.gov (United States)

    Barrett, Timothy J.

    In 2009, ASTM and AASHTO permitted the use of up to 5% interground limestone in ordinary portland cement (OPC) as a part of a change to ASTM C150/AASHTO M85. When this work was initiated a new proposal was being discussed that would enable up to 15% interground limestone cement to be considered in ASTM C595/AASHTO M234. This work served to provide rapid feedback to the state department of transportation and concrete industry for use in discussions regarding these specifications. Since the time this work was initiated, ASTM C595/AASHTO M234 was passed (2012c) and PLCs are now able to be specified, however they are still not widely used. The proposal for increasing the volume of limestone that would be permitted to be interground in cement is designed to enable more sustainable construction, which may significantly reduce the CO2 that is embodied in the built infrastructure while also extending the life of cement quarries. Research regarding the performance of cements with interground limestone has been conducted by the cement industry since these cements became widely used in Europe over three decades ago, however this work focuses on North American Portland Limestone Cements (PLCs) which are specifically designed to achieve similar performance as the OPCs they replace.This thesis presents a two-phase study in which the potential for application of cements containing limestone was assessed. The first phase of this study utilized a fundamental approach to determine whether cement with up to 15% of interground or blended limestone can be used as a direct substitute to ordinary portland cement. The second phase of the study assessed the concern of early age shrinkage and cracking potential when using PLCs, as these cements are typically ground finer than their OPC counterparts. For the first phase of the study, three commercially produced PLCs were obtained and compared to three commercially produced OPCs made from the same clinker. An additional cement was tested

  9. Single-Index Additive Vector Autoregressive Time Series Models

    KAUST Repository

    LI, YEHUA

    2009-09-01

    We study a new class of nonlinear autoregressive models for vector time series, where the current vector depends on single-indexes defined on the past lags and the effects of different lags have an additive form. A sufficient condition is provided for stationarity of such models. We also study estimation of the proposed model using P-splines, hypothesis testing, asymptotics, selection of the order of the autoregression and of the smoothing parameters and nonlinear forecasting. We perform simulation experiments to evaluate our model in various settings. We illustrate our methodology on a climate data set and show that our model provides more accurate yearly forecasts of the El Niño phenomenon, the unusual warming of water in the Pacific Ocean. © 2009 Board of the Foundation of the Scandinavian Journal of Statistics.

  10. Validation of transport models using additive flux minimization technique

    Energy Technology Data Exchange (ETDEWEB)

    Pankin, A. Y.; Kruger, S. E. [Tech-X Corporation, 5621 Arapahoe Ave., Boulder, Colorado 80303 (United States); Groebner, R. J. [General Atomics, San Diego, California 92121 (United States); Hakim, A. [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543-0451 (United States); Kritz, A. H.; Rafiq, T. [Department of Physics, Lehigh University, Bethlehem, Pennsylvania 18015 (United States)

    2013-10-15

    A new additive flux minimization technique is proposed for carrying out the verification and validation (V and V) of anomalous transport models. In this approach, the plasma profiles are computed in time dependent predictive simulations in which an additional effective diffusivity is varied. The goal is to obtain an optimal match between the computed and experimental profile. This new technique has several advantages over traditional V and V methods for transport models in tokamaks and takes advantage of uncertainty quantification methods developed by the applied math community. As a demonstration of its efficiency, the technique is applied to the hypothesis that the paleoclassical density transport dominates in the plasma edge region in DIII-D tokamak discharges. A simplified version of the paleoclassical model that utilizes the Spitzer resistivity for the parallel neoclassical resistivity and neglects the trapped particle effects is tested in this paper. It is shown that a contribution to density transport, in addition to the paleoclassical density transport, is needed in order to describe the experimental profiles. It is found that more additional diffusivity is needed at the top of the H-mode pedestal, and almost no additional diffusivity is needed at the pedestal bottom. The implementation of this V and V technique uses the FACETS::Core transport solver and the DAKOTA toolkit for design optimization and uncertainty quantification. The FACETS::Core solver is used for advancing the plasma density profiles. The DAKOTA toolkit is used for the optimization of plasma profiles and the computation of the additional diffusivity that is required for the predicted density profile to match the experimental profile.

  11. A class of additive-accelerated means regression models for recurrent event data

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In this article, we propose a class of additive-accelerated means regression models for analyzing recurrent event data. The class includes the proportional means model, the additive rates model, the accelerated failure time model, the accelerated rates model and the additive-accelerated rate model as special cases. The new model offers great flexibility in formulating the effects of covariates on the mean functions of counting processes while leaving the stochastic structure completely unspecified. For the inference on the model parameters, estimating equation approaches are derived and asymptotic properties of the proposed estimators are established. In addition, a technique is provided for model checking. The finite-sample behavior of the proposed methods is examined through Monte Carlo simulation studies, and an application to a bladder cancer study is illustrated.

  12. Modeling the influence of limestone addition on cement hydration

    Directory of Open Access Journals (Sweden)

    Ashraf Ragab Mohamed

    2015-03-01

    Full Text Available This paper addresses the influence of using Portland limestone cement “PLC” on cement hydration by characterization of its microstructure development. The European Standard EN 197-1:2011 and Egyptian specification ESS 4756-1/2009 permit the cement to contain up to 20% ground limestone. The computational tools assist in better understanding the influence of limestone additions on cement hydration and microstructure development to facilitate the acceptance of these more economical and ecological materials. μic model has been developed to enable the modeling of microstructural evolution of cementitious materials. In this research μic model is used to simulate both the influence of limestone as fine filler, providing additional surfaces for the nucleation and growth of hydration products. Limestone powder also reacts relatively slow with hydrating cement to form monocarboaluminate (AFmc phase, similar to the mono-sulfoaluminate (AFm phase formed in ordinary Portland cement. The model results reveal that limestone cement has accelerated cement hydration rate, previous experimental results and computer model “cemhyd3d” are used to validate this model.

  13. Genomic breeding value estimation using nonparametric additive regression models

    Directory of Open Access Journals (Sweden)

    Solberg Trygve

    2009-01-01

    Full Text Available Abstract Genomic selection refers to the use of genomewide dense markers for breeding value estimation and subsequently for selection. The main challenge of genomic breeding value estimation is the estimation of many effects from a limited number of observations. Bayesian methods have been proposed to successfully cope with these challenges. As an alternative class of models, non- and semiparametric models were recently introduced. The present study investigated the ability of nonparametric additive regression models to predict genomic breeding values. The genotypes were modelled for each marker or pair of flanking markers (i.e. the predictors separately. The nonparametric functions for the predictors were estimated simultaneously using additive model theory, applying a binomial kernel. The optimal degree of smoothing was determined by bootstrapping. A mutation-drift-balance simulation was carried out. The breeding values of the last generation (genotyped was predicted using data from the next last generation (genotyped and phenotyped. The results show moderate to high accuracies of the predicted breeding values. A determination of predictor specific degree of smoothing increased the accuracy.

  14. Estimation of additive and dominance variance for reproductive traits from different models in Duroc purebred

    OpenAIRE

    Talerngsak Angkuraseranee

    2010-01-01

    The additive and dominance genetic variances of 5,801 Duroc reproductive and growth records were estimated usingBULPF90 PC-PACK. Estimates were obtained for number born alive (NBA), birth weight (BW), number weaned (NW), andweaning weight (WW). Data were analyzed using two mixed model equations. The first model included fixed effects andrandom effects identifying inbreeding depression, additive gene effect and permanent environments effects. The secondmodel was similar to the first model, but...

  15. Generalized Additive Models, Cubic Splines and Penalized Likelihood.

    Science.gov (United States)

    1987-05-22

    in case control studies ). All models in the table include dummy variable to account for the matching. The first 3 lines of the table indicate that OA...Ausoc. Breslow, N. and Day, N. (1980). Statistical methods in cancer research, volume 1- the analysis of case - control studies . International agency

  16. Semiparametric Additive Transformation Model under Current Status Data

    CERN Document Server

    Cheng, Guang

    2011-01-01

    We consider the efficient estimation of the semiparametric additive transformation model with current status data. A wide range of survival models and econometric models can be incorporated into this general transformation framework. We apply the B-spline approach to simultaneously estimate the linear regression vector, the nondecreasing transformation function, and a set of nonparametric regression functions. We show that the parametric estimate is semiparametric efficient in the presence of multiple nonparametric nuisance functions. An explicit consistent B-spline estimate of the asymptotic variance is also provided. All nonparametric estimates are smooth, and shown to be uniformly consistent and have faster than cubic rate of convergence. Interestingly, we observe the convergence rate interfere phenomenon, i.e., the convergence rates of B-spline estimators are all slowed down to equal the slowest one. The constrained optimization is not required in our implementation. Numerical results are used to illustra...

  17. Thermal modelling of extrusion based additive manufacturing of composite materials

    DEFF Research Database (Denmark)

    Jensen, Mathias Laustsen; Sonne, Mads Rostgaard; Hattel, Jesper Henri

    2017-01-01

    One of the hottest topics regarding manufacturing these years is additive manufacturing (AM). AM is a young branch of manufacturing techniques, which by nature is disruptive due to its completely different manufacturing approach, wherein material is added instead of removed. By adding material...... process knowledge, and validating the generated toolpaths before the real manufacturing process takes place: Hence removing time consuming and expensive trial-and-error processes for new products. This study applies a 2D restricted finite volume model aimed to describe thermoplastic Acrylonitrille......-butadiene-styrene (ABS) and thermosetting polyurethane (PU) material extrusion processes. During the experimental evaluation of the produced models it is found that some critical material properties needs to be further investigated to increase the precision of the model. It is however also found that even with only...

  18. Transferability of regional permafrost disturbance susceptibility modelling using generalized linear and generalized additive models

    Science.gov (United States)

    Rudy, Ashley C. A.; Lamoureux, Scott F.; Treitz, Paul; van Ewijk, Karin Y.

    2016-07-01

    To effectively assess and mitigate risk of permafrost disturbance, disturbance-prone areas can be predicted through the application of susceptibility models. In this study we developed regional susceptibility models for permafrost disturbances using a field disturbance inventory to test the transferability of the model to a broader region in the Canadian High Arctic. Resulting maps of susceptibility were then used to explore the effect of terrain variables on the occurrence of disturbances within this region. To account for a large range of landscape characteristics, the model was calibrated using two locations: Sabine Peninsula, Melville Island, NU, and Fosheim Peninsula, Ellesmere Island, NU. Spatial patterns of disturbance were predicted with a generalized linear model (GLM) and generalized additive model (GAM), each calibrated using disturbed and randomized undisturbed locations from both locations and GIS-derived terrain predictor variables including slope, potential incoming solar radiation, wetness index, topographic position index, elevation, and distance to water. Each model was validated for the Sabine and Fosheim Peninsulas using independent data sets while the transferability of the model to an independent site was assessed at Cape Bounty, Melville Island, NU. The regional GLM and GAM validated well for both calibration sites (Sabine and Fosheim) with the area under the receiver operating curves (AUROC) > 0.79. Both models were applied directly to Cape Bounty without calibration and validated equally with AUROC's of 0.76; however, each model predicted disturbed and undisturbed samples differently. Additionally, the sensitivity of the transferred model was assessed using data sets with different sample sizes. Results indicated that models based on larger sample sizes transferred more consistently and captured the variability within the terrain attributes in the respective study areas. Terrain attributes associated with the initiation of disturbances were

  19. Testing exclusion restrictions and additive separability in sample selection models

    DEFF Research Database (Denmark)

    Huber, Martin; Mellace, Giovanni

    2014-01-01

    Standard sample selection models with non-randomly censored outcomes assume (i) an exclusion restriction (i.e., a variable affecting selection, but not the outcome) and (ii) additive separability of the errors in the selection process. This paper proposes tests for the joint satisfaction of these......Standard sample selection models with non-randomly censored outcomes assume (i) an exclusion restriction (i.e., a variable affecting selection, but not the outcome) and (ii) additive separability of the errors in the selection process. This paper proposes tests for the joint satisfaction...... of these assumptions by applying the approach of Huber and Mellace (Testing instrument validity for LATE identification based on inequality moment constraints, 2011) (for testing instrument validity under treatment endogeneity) to the sample selection framework. We show that the exclusion restriction and additive...... separability imply two testable inequality constraints that come from both point identifying and bounding the outcome distribution of the subpopulation that is always selected/observed. We apply the tests to two variables for which the exclusion restriction is frequently invoked in female wage regressions: non...

  20. Two-stage local M-estimation of additive models

    Institute of Scientific and Technical Information of China (English)

    JIANG JianCheng; LI JianTao

    2008-01-01

    This paper studies local M-estimation of the nonparametric components of additive models. A two-stage local M-estimation procedure is proposed for estimating the additive components and their derivatives. Under very mild conditions, the proposed estimators of each additive component and its derivative are jointly asymptotically normal and share the same asymptotic distributions as they would be if the other components were known. The established asymptotic results also hold for two particular local M-estimations: the local least squares and least absolute deviation estimations. However,for general two-stage local M-estimation with continuous and nonlinear ψ-functions, its implementation is time-consuming. To reduce the computational burden, one-step approximations to the two-stage local M-estimators are developed. The one-step estimators are shown to achieve the same efficiency as the fully iterative two-stage local M-estimators, which makes the two-stage local M-estimation more feasible in practice. The proposed estimators inherit the advantages and at the same time overcome the disadvantages of the local least-squares based smoothers. In addition, the practical implementation of the proposed estimation is considered in details. Simulations demonstrate the merits of the two-stage local M-estimation, and a real example illustrates the performance of the methodology.

  1. Two-stage local M-estimation of additive models

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    This paper studies local M-estimation of the nonparametric components of additive models.A two-stage local M-estimation procedure is proposed for estimating the additive components and their derivatives.Under very mild conditions,the proposed estimators of each additive component and its derivative are jointly asymptotically normal and share the same asymptotic distributions as they would be if the other components were known.The established asymptotic results also hold for two particular local M-estimations:the local least squares and least absolute deviation estimations.However,for general two-stage local M-estimation with continuous and nonlinear ψ-functions,its implementation is time-consuming.To reduce the computational burden,one-step approximations to the two-stage local M-estimators are developed.The one-step estimators are shown to achieve the same effciency as the fully iterative two-stage local M-estimators,which makes the two-stage local M-estimation more feasible in practice.The proposed estimators inherit the advantages and at the same time overcome the disadvantages of the local least-squares based smoothers.In addition,the practical implementation of the proposed estimation is considered in details.Simulations demonstrate the merits of the two-stage local M-estimation,and a real example illustrates the performance of the methodology.

  2. RELAP5-3D Code Includes Athena Features and Models

    Energy Technology Data Exchange (ETDEWEB)

    Richard A. Riemke; Cliff B. Davis; Richard R. Schultz

    2006-07-01

    Version 2.3 of the RELAP5-3D computer program includes all features and models previously available only in the ATHENA version of the code. These include the addition of new working fluids (i.e., ammonia, blood, carbon dioxide, glycerol, helium, hydrogen, lead-bismuth, lithium, lithium-lead, nitrogen, potassium, sodium, and sodium-potassium) and a magnetohydrodynamic model that expands the capability of the code to model many more thermal-hydraulic systems. In addition to the new working fluids along with the standard working fluid water, one or more noncondensable gases (e.g., air, argon, carbon dioxide, carbon monoxide, helium, hydrogen, krypton, nitrogen, oxygen, sf6, xenon) can be specified as part of the vapor/gas phase of the working fluid. These noncondensable gases were in previous versions of RELAP5- 3D. Recently four molten salts have been added as working fluids to RELAP5-3D Version 2.4, which has had limited release. These molten salts will be in RELAP5-3D Version 2.5, which will have a general release like RELAP5-3D Version 2.3. Applications that use these new features and models are discussed in this paper.

  3. Sensitivity analysis of geometric errors in additive manufacturing medical models.

    Science.gov (United States)

    Pinto, Jose Miguel; Arrieta, Cristobal; Andia, Marcelo E; Uribe, Sergio; Ramos-Grez, Jorge; Vargas, Alex; Irarrazaval, Pablo; Tejos, Cristian

    2015-03-01

    Additive manufacturing (AM) models are used in medical applications for surgical planning, prosthesis design and teaching. For these applications, the accuracy of the AM models is essential. Unfortunately, this accuracy is compromised due to errors introduced by each of the building steps: image acquisition, segmentation, triangulation, printing and infiltration. However, the contribution of each step to the final error remains unclear. We performed a sensitivity analysis comparing errors obtained from a reference with those obtained modifying parameters of each building step. Our analysis considered global indexes to evaluate the overall error, and local indexes to show how this error is distributed along the surface of the AM models. Our results show that the standard building process tends to overestimate the AM models, i.e. models are larger than the original structures. They also show that the triangulation resolution and the segmentation threshold are critical factors, and that the errors are concentrated at regions with high curvatures. Errors could be reduced choosing better triangulation and printing resolutions, but there is an important need for modifying some of the standard building processes, particularly the segmentation algorithms. Copyright © 2015 IPEM. Published by Elsevier Ltd. All rights reserved.

  4. Estimation and variable selection for generalized additive partial linear models

    KAUST Repository

    Wang, Li

    2011-08-01

    We study generalized additive partial linear models, proposing the use of polynomial spline smoothing for estimation of nonparametric functions, and deriving quasi-likelihood based estimators for the linear parameters. We establish asymptotic normality for the estimators of the parametric components. The procedure avoids solving large systems of equations as in kernel-based procedures and thus results in gains in computational simplicity. We further develop a class of variable selection procedures for the linear parameters by employing a nonconcave penalized quasi-likelihood, which is shown to have an asymptotic oracle property. Monte Carlo simulations and an empirical example are presented for illustration. © Institute of Mathematical Statistics, 2011.

  5. Additive Manufacturing of Medical Models--Applications in Rhinology.

    Science.gov (United States)

    Raos, Pero; Klapan, Ivica; Galeta, Tomislav

    2015-09-01

    In the paper we are introducing guidelines and suggestions for use of 3D image processing SW in head pathology diagnostic and procedures for obtaining physical medical model by additive manufacturing/rapid prototyping techniques, bearing in mind the improvement of surgery performance, its maximum security and faster postoperative recovery of patients. This approach has been verified in two case reports. In the treatment we used intelligent classifier-schemes for abnormal patterns using computer-based system for 3D-virtual and endoscopic assistance in rhinology, with appropriate visualization of anatomy and pathology within the nose, paranasal sinuses, and scull base area.

  6. Malliavin's calculus in insider models: Additional utility and free lunches

    OpenAIRE

    2002-01-01

    We consider simple models of financial markets with regular traders and insiders possessing some extra information hidden in a random variable which is accessible to the regular trader only at the end of the trading interval. The problems we focus on are the calculation of the additional utility of the insider and a study of his free lunch possibilities. The information drift, i.e. the drift to eliminate in order to preserve the martingale property in the insider's filtration, turns out to be...

  7. BALANCED SCORECARDS EVALUATION MODEL THAT INCLUDES ELEMENTS OF ENVIRONMENTAL MANAGEMENT SYSTEM USING AHP MODEL

    Directory of Open Access Journals (Sweden)

    Jelena Jovanović

    2010-03-01

    Full Text Available The research is oriented on improvement of environmental management system (EMS using BSC (Balanced Scorecard model that presents strategic model of measurem ents and improvement of organisational performance. The research will present approach of objectives and environmental management me trics involvement (proposed by literature review in conventional BSC in "Ad Barska plovi dba" organisation. Further we will test creation of ECO-BSC model based on business activities of non-profit organisations in order to improve envir onmental management system in parallel with other systems of management. Using this approach we may obtain 4 models of BSC that includ es elements of environmen tal management system for AD "Barska plovidba". Taking into acc ount that implementation and evaluation need long period of time in AD "Barska plovidba", the final choice will be based on 14598 (Information technology - Software product evaluation and ISO 9126 (Software engineering - Product quality using AHP method. Those standards are usually used for evaluation of quality software product and computer programs that serve in organisation as support and factors for development. So, AHP model will be bas ed on evolution criteria based on suggestion of ISO 9126 standards and types of evaluation from two evaluation teams. Members of team & will be experts in BSC and environmental management system that are not em ployed in AD "Barska Plovidba" organisation. The members of team 2 will be managers of AD "Barska Plovidba" organisation (including manage rs from environmental department. Merging results based on previously cr eated two AHP models, one can obtain the most appropriate BSC that includes elements of environmental management system. The chosen model will present at the same time suggestion for approach choice including ecological metrics in conventional BSC model for firm that has at least one ECO strategic orientation.

  8. Cost models of additive manufacturing: A literature review

    Directory of Open Access Journals (Sweden)

    G. Costabile

    2016-11-01

    Full Text Available From the past decades, increasing attention has been paid to the quality level of technological and mechanical properties achieved by the Additive Manufacturing (AM; these two elements have achieved a good performance, and it is possible to compare this with the results achieved by traditional technology. Therefore, the AM maturity is high enough to let industries adopt this technology in a more general production framework as the mechanical manufacturing industrial one is. Since the technological and mechanical properties are also beneficial for the materials produced with AM, the primary objective of this paper is to focus more on managerial facets, such as the cost control of a production environment, where these new technologies are present. This paper aims to analyse the existing literature about the cost models developed specifically for AM from an operations management point of view and discusses the strengths and weaknesses of all models.

  9. Multiscale Modeling of Powder Bed-Based Additive Manufacturing

    Science.gov (United States)

    Markl, Matthias; Körner, Carolin

    2016-07-01

    Powder bed fusion processes are additive manufacturing technologies that are expected to induce the third industrial revolution. Components are built up layer by layer in a powder bed by selectively melting confined areas, according to sliced 3D model data. This technique allows for manufacturing of highly complex geometries hardly machinable with conventional technologies. However, the underlying physical phenomena are sparsely understood and difficult to observe during processing. Therefore, an intensive and expensive trial-and-error principle is applied to produce components with the desired dimensional accuracy, material characteristics, and mechanical properties. This review presents numerical modeling approaches on multiple length scales and timescales to describe different aspects of powder bed fusion processes. In combination with tailored experiments, the numerical results enlarge the process understanding of the underlying physical mechanisms and support the development of suitable process strategies and component topologies.

  10. Kinetics approach to modeling of polymer additive degradation in lubricants

    Institute of Scientific and Technical Information of China (English)

    llyaI.KUDISH; RubenG.AIRAPETYAN; Michael; J.; COVITCH

    2001-01-01

    A kinetics problem for a degrading polymer additive dissolved in a base stock is studied.The polymer degradation may be caused by the combination of such lubricant flow parameters aspressure, elongational strain rate, and temperature as well as lubricant viscosity and the polymercharacteristics (dissociation energy, bead radius, bond length, etc.). A fundamental approach tothe problem of modeling mechanically induced polymer degradation is proposed. The polymerdegradation is modeled on the basis of a kinetic equation for the density of the statistical distribu-tion of polymer molecules as a function of their molecular weight. The integrodifferential kineticequation for polymer degradation is solved numerically. The effects of pressure, elongational strainrate, temperature, and lubricant viscosity on the process of lubricant degradation are considered.The increase of pressure promotes fast degradation while the increase of temperature delaysdegradation. A comparison of a numerically calculated molecular weight distribution with an ex-perimental one obtained in bench tests showed that they are in excellent agreement with eachother.

  11. Safe distance car-following model including backward-looking and its stability analysis

    Science.gov (United States)

    Yang, Da; Jin, Peter Jing; Pu, Yun; Ran, Bin

    2013-03-01

    The focus of this paper is the car-following behavior including backward-looking, simply called the bi-directional looking car-following behavior. This study is motivated by the potential changes of the physical properties of traffic flow caused by the fast developing intelligent transportation system (ITS), especially the new connected vehicle technology. Existing studies on this topic focused on general motors (GM) models and optimal velocity (OV) models. The safe distance car-following model, Gipps' model, which is more widely used in practice have not drawn too much attention in the bi-directional looking context. This paper explores the property of the bi-directional looking extension of Gipps' safe distance model. The stability condition of the proposed model is derived using the linear stability theory and is verified using numerical simulations. The impacts of the driver and vehicle characteristics appeared in the proposed model on the traffic flow stability are also investigated. It is found that taking into account the backward-looking effect in car-following has three types of effect on traffic flow: stabilizing, destabilizing and producing non-physical phenomenon. This conclusion is more sophisticated than the study results based on the OV bi-directional looking car-following models. Moreover, the drivers who have the smaller reaction time or the larger additional delay and think the other vehicles have larger maximum decelerations can stabilize traffic flow.

  12. Model Checking Vector Addition Systems with one zero-test

    CERN Document Server

    Bonet, Rémi; Leroux, Jérôme; Zeitoun, Marc

    2012-01-01

    We design a variation of the Karp-Miller algorithm to compute, in a forward manner, a finite representation of the cover (i.e., the downward closure of the reachability set) of a vector addition system with one zero-test. This algorithm yields decision procedures for several problems for these systems, open until now, such as place-boundedness or LTL model-checking. The proof techniques to handle the zero-test are based on two new notions of cover: the refined and the filtered cover. The refined cover is a hybrid between the reachability set and the classical cover. It inherits properties of the reachability set: equality of two refined covers is undecidable, even for usual Vector Addition Systems (with no zero-test), but the refined cover of a Vector Addition System is a recursive set. The second notion of cover, called the filtered cover, is the central tool of our algorithms. It inherits properties of the classical cover, and in particular, one can effectively compute a finite representation of this set, e...

  13. Primary circuit iodine model addition to IMPAIR-3

    Energy Technology Data Exchange (ETDEWEB)

    Osetek, D.J.; Louie, D.L.Y. [Los Alamos Technical Associates, Inc., Albuquerque, NM (United States); Guntay, S.; Cripps, R. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1996-12-01

    As part of a continuing effort to provide the U.S. Department of Energy (DOE) Advanced Reactor Severe Accident Program (ARSAP) with complete iodine analysis capability, a task was undertaken to expand the modeling of IMPAIR-3, an iodine chemistry code. The expanded code will enable the DOE to include detailed iodine behavior in the assessment of severe accident source terms used in the licensing of U.S. Advanced Light Water Reactors (ALWRs). IMPAIR-3 was developed at the Paul Scherrer Institute (PSI), Switzerland, and has been used by ARSAP for the past two years to analyze containment iodine chemistry for ALWR source term analyses. IMPAIR-3 is primarily a containment code but the iodine chemistry inside the primary circuit (the Reactor Coolant System or RCS) may influence the iodine species released into the the containment; therefore, a RCS iodine chemistry model must be implemented in IMPAIR-3 to ensure thorough source term analysis. The ARSAP source term team and the PSI IMPAIR-3 developers are working together to accomplish this task. This cooperation is divided into two phases. Phase I, taking place in 1996, involves developing a stand-alone RCS iodine chemistry program called IMPRCS (IMPAIR -Reactor Coolant System). This program models a number of the chemical and physical processes of iodine that are thought to be important at conditions of high temperature and pressure in the RCS. In Phase II, which is tentatively scheduled for 1997, IMPRCS will be implemented as a subroutine in IMPAIR-3. To ensure an efficient calculation, an interface/tracking system will be developed to control the use of the RCS model from the containment model. These two models will be interfaced in such a way that once the iodine is released from the RCS, it will no longer be tracked by the RCS model but will be tracked by the containment model. All RCS thermal-hydraulic parameters will be provided by other codes. (author) figs., tabs., refs.

  14. Metal Big Area Additive Manufacturing: Process Modeling and Validation

    Energy Technology Data Exchange (ETDEWEB)

    Simunovic, Srdjan [ORNL; Nycz, Andrzej [ORNL; Noakes, Mark W [ORNL; Chin, Charlie [Dassault Systemes; Oancea, Victor [Dassault Systemes

    2017-01-01

    Metal Big Area Additive Manufacturing (mBAAM) is a new additive manufacturing (AM) technology for printing large-scale 3D objects. mBAAM is based on the gas metal arc welding process and uses a continuous feed of welding wire to manufacture an object. An electric arc forms between the wire and the substrate, which melts the wire and deposits a bead of molten metal along the predetermined path. In general, the welding process parameters and local conditions determine the shape of the deposited bead. The sequence of the bead deposition and the corresponding thermal history of the manufactured object determine the long range effects, such as thermal-induced distortions and residual stresses. Therefore, the resulting performance or final properties of the manufactured object are dependent on its geometry and the deposition path, in addition to depending on the basic welding process parameters. Physical testing is critical for gaining the necessary knowledge for quality prints, but traversing the process parameter space in order to develop an optimized build strategy for each new design is impractical by pure experimental means. Computational modeling and optimization may accelerate development of a build process strategy and saves time and resources. Because computational modeling provides these opportunities, we have developed a physics-based Finite Element Method (FEM) simulation framework and numerical models to support the mBAAM process s development and design. In this paper, we performed a sequentially coupled heat transfer and stress analysis for predicting the final deformation of a small rectangular structure printed using the mild steel welding wire. Using the new simulation technologies, material was progressively added into the FEM simulation as the arc weld traversed the build path. In the sequentially coupled heat transfer and stress analysis, the heat transfer was performed to calculate the temperature evolution, which was used in a stress analysis to

  15. Model for resistance evolution in shape memory alloys including R-phase

    Science.gov (United States)

    Brammajyosula, Ravindra; Buravalla, Vidyashankar; Khandelwal, Ashish

    2011-03-01

    The electrical resistance behavior of a shape memory alloy (SMA) wire can be used for sensing the state of an SMA device. Hence, this study investigates the resistance evolution in SMAs. A lumped parameter model with cosine kinetics to capture the resistance variation during the phase transformation is developed. Several SMA materials show the presence of trigonal or rhombohedral (R) phase as an intermediate phase, apart from the commonly recognized austenite and martensite phases. Most of the SMA models ignore the R-phase effect in their prediction of thermomechanical response. This may be acceptable since the changes in thermomechanical response associated with the R-phase are relatively less. However, the resistivity related effects are pronounced in the presence of the R-phase and its appearance introduces non-monotonicity in the resistivity evolution. This leads to additional complexities in the use of resistance signal for sensing and control. Hence, a lumped model is developed here for resistance evolution including the R-phase effects. A phase-diagram-based model is proposed for predicting electro-thermomechanical response. Both steady state hysteretic response and transient response are modeled. The model predictions are compared with the available test data. Numerical studies have shown that the model is able to capture all the essential features of the resistance evolution in SMAs in the presence of the R-phase.

  16. Kinetic modeling of rhamnolipid production by Pseudomonas aeruginosa PAO1 including cell density-dependent regulation.

    Science.gov (United States)

    Henkel, Marius; Schmidberger, Anke; Vogelbacher, Markus; Kühnert, Christian; Beuker, Janina; Bernard, Thomas; Schwartz, Thomas; Syldatk, Christoph; Hausmann, Rudolf

    2014-08-01

    The production of rhamnolipid biosurfactants by Pseudomonas aeruginosa is under complex control of a quorum sensing-dependent regulatory network. Due to a lack of understanding of the kinetics applicable to the process and relevant interrelations of variables, current processes for rhamnolipid production are based on heuristic approaches. To systematically establish a knowledge-based process for rhamnolipid production, a deeper understanding of the time-course and coupling of process variables is required. By combining reaction kinetics, stoichiometry, and experimental data, a process model for rhamnolipid production with P. aeruginosa PAO1 on sunflower oil was developed as a system of coupled ordinary differential equations (ODEs). In addition, cell density-based quorum sensing dynamics were included in the model. The model comprises a total of 36 parameters, 14 of which are yield coefficients and 7 of which are substrate affinity and inhibition constants. Of all 36 parameters, 30 were derived from dedicated experimental results, literature, and databases and 6 of them were used as fitting parameters. The model is able to describe data on biomass growth, substrates, and products obtained from a reference batch process and other validation scenarios. The model presented describes the time-course and interrelation of biomass, relevant substrates, and products on a process level while including a kinetic representation of cell density-dependent regulatory mechanisms.

  17. Additional Research Needs to Support the GENII Biosphere Models

    Energy Technology Data Exchange (ETDEWEB)

    Napier, Bruce A.; Snyder, Sandra F.; Arimescu, Carmen

    2013-11-30

    In the course of evaluating the current parameter needs for the GENII Version 2 code (Snyder et al. 2013), areas of possible improvement for both the data and the underlying models have been identified. As the data review was implemented, PNNL staff identified areas where the models can be improved both to accommodate the locally significant pathways identified and also to incorporate newer models. The areas are general data needs for the existing models and improved formulations for the pathway models. It is recommended that priorities be set by NRC staff to guide selection of the most useful improvements in a cost-effective manner. Suggestions are made based on relatively easy and inexpensive changes, and longer-term more costly studies. In the short term, there are several improved model formulations that could be applied to the GENII suite of codes to make them more generally useful. • Implementation of the separation of the translocation and weathering processes • Implementation of an improved model for carbon-14 from non-atmospheric sources • Implementation of radon exposure pathways models • Development of a KML processor for the output report generator module data that are calculated on a grid that could be superimposed upon digital maps for easier presentation and display • Implementation of marine mammal models (manatees, seals, walrus, whales, etc.). Data needs in the longer term require extensive (and potentially expensive) research. Before picking any one radionuclide or food type, NRC staff should perform an in-house review of current and anticipated environmental analyses to select “dominant” radionuclides of interest to allow setting of cost-effective priorities for radionuclide- and pathway-specific research. These include • soil-to-plant uptake studies for oranges and other citrus fruits, and • Development of models for evaluation of radionuclide concentration in highly-processed foods such as oils and sugars. Finally, renewed

  18. Modelling Mediterranean agro-ecosystems by including agricultural trees in the LPJmL model

    Science.gov (United States)

    Fader, M.; von Bloh, W.; Shi, S.; Bondeau, A.; Cramer, W.

    2015-11-01

    In the Mediterranean region, climate and land use change are expected to impact on natural and agricultural ecosystems by warming, reduced rainfall, direct degradation of ecosystems and biodiversity loss. Human population growth and socioeconomic changes, notably on the eastern and southern shores, will require increases in food production and put additional pressure on agro-ecosystems and water resources. Coping with these challenges requires informed decisions that, in turn, require assessments by means of a comprehensive agro-ecosystem and hydrological model. This study presents the inclusion of 10 Mediterranean agricultural plants, mainly perennial crops, in an agro-ecosystem model (Lund-Potsdam-Jena managed Land - LPJmL): nut trees, date palms, citrus trees, orchards, olive trees, grapes, cotton, potatoes, vegetables and fodder grasses. The model was successfully tested in three model outputs: agricultural yields, irrigation requirements and soil carbon density. With the development presented in this study, LPJmL is now able to simulate in good detail and mechanistically the functioning of Mediterranean agriculture with a comprehensive representation of ecophysiological processes for all vegetation types (natural and agricultural) and in a consistent framework that produces estimates of carbon, agricultural and hydrological variables for the entire Mediterranean basin. This development paves the way for further model extensions aiming at the representation of alternative agro-ecosystems (e.g. agroforestry), and opens the door for a large number of applications in the Mediterranean region, for example assessments of the consequences of land use transitions, the influence of management practices and climate change impacts.

  19. Modelling Mediterranean agro-ecosystems by including agricultural trees in the LPJmL model

    Directory of Open Access Journals (Sweden)

    M. Fader

    2015-06-01

    Full Text Available Climate and land use change in the Mediterranean region is expected to affect natural and agricultural ecosystems by decreases in precipitation, increases in temperature as well as biodiversity loss and anthropogenic degradation of natural resources. Demographic growth in the Eastern and Southern shores will require increases in food production and put additional pressure on agro-ecosystems and water resources. Coping with these challenges requires informed decisions that, in turn, require assessments by means of a comprehensive agro-ecosystem and hydrological model. This study presents the inclusion of 10 Mediterranean agricultural plants, mainly perennial crops, in an agro-ecosystem model (LPJmL: nut trees, date palms, citrus trees, orchards, olive trees, grapes, cotton, potatoes, vegetables and fodder grasses. The model was successfully tested in three model outputs: agricultural yields, irrigation requirements and soil carbon density. With the development presented in this study, LPJmL is now able to simulate in good detail and mechanistically the functioning of Mediterranean agriculture with a comprehensive representation of ecophysiological processes for all vegetation types (natural and agricultural and in a consistent framework that produces estimates of carbon, agricultural and hydrological variables for the entire Mediterranean basin. This development pave the way for further model extensions aiming at the representation of alternative agro-ecosystems (e.g. agroforestry, and opens the door for a large number of applications in the Mediterranean region, for example assessments on the consequences of land use transitions, the influence of management practices and climate change impacts.

  20. A full model for simulation of electrochemical cells including complex behavior

    Science.gov (United States)

    Esperilla, J. J.; Félez, J.; Romero, G.; Carretero, A.

    This communication presents a model of electrochemical cells developed in order to simulate their electrical, chemical and thermal behavior showing the differences when thermal effects are or not considered in the charge-discharge process. The work presented here has been applied to the particular case of the Pb,PbSO 4|H 2SO 4 (aq)|PbO 2,Pb cell, which forms the basis of the lead-acid batteries so widely used in the automotive industry and as traction batteries in electric or hybrid vehicles. Each half-cell is considered independently in the model. For each half-cell, in addition to the main electrode reaction, a secondary reaction is considered: the hydrogen evolution reaction in the negative electrode and the oxygen evolution reaction in the positive. The equilibrium potential is calculated with the Nernst equation, in which the activity coefficients are fitted to an exponential function using experimental data. On the other hand, the two main mechanisms that produce the overpotential are considered, that is the activation or charge transfer and the diffusion mechanisms. First, an isothermal model has been studied in order to show the behavior of the main phenomena. A more complex model has also been studied including thermal behavior. This model is very useful in the case of traction batteries in electric and hybrid vehicles where high current intensities appear. Some simulation results are also presented in order to show the accuracy of the proposed models.

  1. SPheno 3.1: extensions including flavour, CP-phases and models beyond the MSSM

    Science.gov (United States)

    Porod, W.; Staub, F.

    2012-11-01

    high scale parameters by evaluating the corresponding renormalisation group equations. These parameters must be consistent with the requirement of correct electroweak symmetry breaking. The second issue is to use the obtained masses and couplings for calculating decay widths and branching ratios of supersymmetric particles as well as the cross sections for these particles in electron-positron annihilation. The third issue is to calculate low energy constraints in the B-meson sector such as BR(b s), MB s, rare lepton decays, such as BR(e), the SUSY contributions to anomalous magnetic moments and electric dipole moments of leptons, the SUSY contributions to the ρ parameter as well as lepton flavour violating Z decays. Solution method: The renormalisation connecting a high scale and the electroweak scale is calculated by the Runge-Kutta method. Iteration provides a solution consistent with the multi-boundary conditions. In case of three-body decays and for the calculation of initial state radiation Gaussian quadrature is used for the numerical solution of the integrals. Reasons for new version: Inclusion of new models as well as additional observables. Moreover, a new standard for data transfer had been established, which is now supported. Summary of revisions: The already existing models have been extended to include also CP-violation and flavour mixing. The data transfer is done using the so-called SLHA2 standard. In addition new models have been included: all three types of seesaw models as well as bilinear R-parity violation. Moreover, additional observables are calculated: branching ratios for flavour violating lepton decays, EDMs of leptons and of the neutron, CP-violating mass difference in the B-meson sector and branching ratios for flavour violating b-quark decays. Restrictions: In case of R-parity violation the cross sections are not calculated. Running time: 0.2 seconds on an Intel(R) Core(TM)2 Duo CPU T9900 with 3.06 GHz

  2. Smart Voyage Planning Model Sensitivity Analysis Using Ocean and Atmospheric Models Including Ensemble Methods

    Science.gov (United States)

    2012-09-01

    ATMOSPHERIC MODELS INCLUDING ENSEMBLE METHODS Scott E. Miller Lieutenant Commander, United States Navy B.S., University of South Carolina, 2000 B.S...Typical gas turbine fuel consumption curve and relationship to sea state .......51  Figure 16.  DDG 58 speed reduction curves for bow seas...Day Time Group ECDIS-N Electronic Chart Display and Information System – Navy ECMWF European Center for Medium Range Weather Forecasts EFAS

  3. Versatility of cooperative transcriptional activation: a thermodynamical modeling analysis for greater-than-additive and less-than-additive effects.

    Directory of Open Access Journals (Sweden)

    Till D Frank

    Full Text Available We derive a statistical model of transcriptional activation using equilibrium thermodynamics of chemical reactions. We examine to what extent this statistical model predicts synergy effects of cooperative activation of gene expression. We determine parameter domains in which greater-than-additive and less-than-additive effects are predicted for cooperative regulation by two activators. We show that the statistical approach can be used to identify different causes of synergistic greater-than-additive effects: nonlinearities of the thermostatistical transcriptional machinery and three-body interactions between RNA polymerase and two activators. In particular, our model-based analysis suggests that at low transcription factor concentrations cooperative activation cannot yield synergistic greater-than-additive effects, i.e., DNA transcription can only exhibit less-than-additive effects. Accordingly, transcriptional activity turns from synergistic greater-than-additive responses at relatively high transcription factor concentrations into less-than-additive responses at relatively low concentrations. In addition, two types of re-entrant phenomena are predicted. First, our analysis predicts that under particular circumstances transcriptional activity will feature a sequence of less-than-additive, greater-than-additive, and eventually less-than-additive effects when for fixed activator concentrations the regulatory impact of activators on the binding of RNA polymerase to the promoter increases from weak, to moderate, to strong. Second, for appropriate promoter conditions when activator concentrations are increased then the aforementioned re-entrant sequence of less-than-additive, greater-than-additive, and less-than-additive effects is predicted as well. Finally, our model-based analysis suggests that even for weak activators that individually induce only negligible increases in promoter activity, promoter activity can exhibit greater-than-additive

  4. Including policy and management in socio-hydrology models: initial conceptualizations

    Science.gov (United States)

    Hermans, Leon; Korbee, Dorien

    2017-04-01

    Socio-hydrology studies the interactions in coupled human-water systems. So far, the use of dynamic models that capture the direct feedback between societal and hydrological systems has been dominant. What has not yet been included with any particular emphasis, is the policy or management layer, which is a central element in for instance integrated water resources management (IWRM) or adaptive delta management (ADM). Studying the direct interactions between human-water systems generates knowledges that eventually helps influence these interactions in ways that may ensure better outcomes - for society and for the health and sustainability of water systems. This influence sometimes occurs through spontaneous emergence, uncoordinated by societal agents - private sector, citizens, consumers, water users. However, the term 'management' in IWRM and ADM also implies an additional coordinated attempt through various public actors. This contribution is a call to include the policy and management dimension more prominently into the research focus of the socio-hydrology field, and offers first conceptual variables that should be considered in attempts to include this policy or management layer in socio-hydrology models. This is done by drawing on existing frameworks to study policy processes throughout both planning and implementation phases. These include frameworks such as the advocacy coalition framework, collective learning and policy arrangements, which all emphasis longer-term dynamics and feedbacks between actor coalitions in strategic planning and implementation processes. A case about longter-term dynamics in the management of the Haringvliet in the Netherlands is used to illustrate the paper.

  5. Analysis of electronic models for solar cells including energy resolved defect densities

    Energy Technology Data Exchange (ETDEWEB)

    Glitzky, Annegret

    2010-07-01

    We introduce an electronic model for solar cells including energy resolved defect densities. The resulting drift-diffusion model corresponds to a generalized van Roosbroeck system with additional source terms coupled with ODEs containing space and energy as parameters for all defect densities. The system has to be considered in heterostructures and with mixed boundary conditions from device simulation. We give a weak formulation of the problem. If the boundary data and the sources are compatible with thermodynamic equilibrium the free energy along solutions decays monotonously. In other cases it may be increasing, but we estimate its growth. We establish boundedness and uniqueness results and prove the existence of a weak solution. This is done by considering a regularized problem, showing its solvability and the boundedness of its solutions independent of the regularization level. (orig.)

  6. Degree of multicollinearity and variables involved in linear dependence in additive-dominant models

    Directory of Open Access Journals (Sweden)

    Juliana Petrini

    2012-12-01

    Full Text Available The objective of this work was to assess the degree of multicollinearity and to identify the variables involved in linear dependence relations in additive-dominant models. Data of birth weight (n=141,567, yearling weight (n=58,124, and scrotal circumference (n=20,371 of Montana Tropical composite cattle were used. Diagnosis of multicollinearity was based on the variance inflation factor (VIF and on the evaluation of the condition indexes and eigenvalues from the correlation matrix among explanatory variables. The first model studied (RM included the fixed effect of dam age class at calving and the covariates associated to the direct and maternal additive and non-additive effects. The second model (R included all the effects of the RM model except the maternal additive effects. Multicollinearity was detected in both models for all traits considered, with VIF values of 1.03 - 70.20 for RM and 1.03 - 60.70 for R. Collinearity increased with the increase of variables in the model and the decrease in the number of observations, and it was classified as weak, with condition index values between 10.00 and 26.77. In general, the variables associated with additive and non-additive effects were involved in multicollinearity, partially due to the natural connection between these covariables as fractions of the biological types in breed composition.

  7. A nonparametric dynamic additive regression model for longitudinal data

    DEFF Research Database (Denmark)

    Martinussen, Torben; Scheike, Thomas H.

    2000-01-01

    dynamic linear models, estimating equations, least squares, longitudinal data, nonparametric methods, partly conditional mean models, time-varying-coefficient models......dynamic linear models, estimating equations, least squares, longitudinal data, nonparametric methods, partly conditional mean models, time-varying-coefficient models...

  8. Product versus additive threshold models for analysis of reproduction outcomes in animal genetics.

    Science.gov (United States)

    David, I; Bodin, L; Gianola, D; Legarra, A; Manfredi, E; Robert-Granié, C

    2009-08-01

    The phenotypic observation of some reproduction traits (e.g., insemination success, interval from lambing to insemination) is the result of environmental and genetic factors acting on 2 individuals: the male and female involved in a mating couple. In animal genetics, the main approach (called additive model) proposed for studying such traits assumes that the phenotype is linked to a purely additive combination, either on the observed scale for continuous traits or on some underlying scale for discrete traits, of environmental and genetic effects affecting the 2 individuals. Statistical models proposed for studying human fecundability generally consider reproduction outcomes as the product of hypothetical unobservable variables. Taking inspiration from these works, we propose a model (product threshold model) for studying a binary reproduction trait that supposes that the observed phenotype is the product of 2 unobserved phenotypes, 1 for each individual. We developed a Gibbs sampling algorithm for fitting a Bayesian product threshold model including additive genetic effects and showed by simulation that it is feasible and that it provides good estimates of the parameters. We showed that fitting an additive threshold model to data that are simulated under a product threshold model provides biased estimates, especially for individuals with high breeding values. A main advantage of the product threshold model is that, in contrast to the additive model, it provides distinct estimates of fixed effects affecting each of the 2 unobserved phenotypes.

  9. Improved Subseasonal Prediction with Advanced Coupled Models including the 30km FIM-HYCOM Coupled Model

    Science.gov (United States)

    Benjamin, Stan; Sun, Shan; Grell, Georg; Green, Benjamin; Bleck, Rainer; Li, Haiqin

    2017-04-01

    Extreme events for subseasonal duration have been linked to multi-week processes related to onset, duration, and cessation of blocking events or, more generally, quasi-stationary waves. Results will be shown from different sets of 32-day prediction experiments (3200 runs each) over a 16-year period for earth system processes key for subseasonal prediction for different resolution, numerics, and physics using the FIM-HYCOM coupled model. The coupled atmosphere (FIM) and ocean (HYCOM) modeling system is a relatively new coupled atmosphere-ocean model developed for subseasonal to seasonal prediction (Green et al. 2017 Mon.Wea.Rev. accepted, Bleck et al 2015 Mon. Wea. Rev.). Both component models operate on a common icosahedral horizontal grid and use an adaptive hybrid vertical coordinate (sigma-isentropic in FIM and sigma-isopycnic in HYCOM). FIM-HYCOM has been used to conduct 16 years of subseasonal retrospective forecasts following the NOAA Subseasonal (SubX) NMME protocol (32-day forward integrations), run with 4 ensemble members per week. Results from this multi-year FIM-HYCOM hindcast include successful forecasts out to 14-20 days for stratospheric warming events (from archived 10 hPa fields), improved MJO predictability (Green et al. 2017) using the Grell-Freitas (2014, ACP) scale-aware cumulus scheme instead of the Simplified Arakawa-Schubert scheme, and little sensitivity to resolution for blocking frequency. Forecast skill of metrics from FIM-HYCOM including 500 hPa heights and MJO index is at least comparable to that of the operational Climate Forecast System (CFSv2) used by the National Centers for Environmental Prediction. Subseasonal skill is improved with a limited multi-model (FIM-HYCOM and CFSv2), consistent with previous seasonal multi-model ensemble results. Ongoing work will also be reported on for adding inline aerosol/chemistry treatment to the coupled FIM-HYCOM model and for advanced approaches to subgrid-scale clouds to address regional biases

  10. Fluid-structure interaction including volumetric coupling with homogenised subdomains for modeling respiratory mechanics.

    Science.gov (United States)

    Yoshihara, Lena; Roth, Christian J; Wall, Wolfgang A

    2017-04-01

    In this article, a novel approach is presented for combining standard fluid-structure interaction with additional volumetric constraints to model fluid flow into and from homogenised solid domains. The proposed algorithm is particularly interesting for investigations in the field of respiratory mechanics as it enables the mutual coupling of airflow in the conducting part and local tissue deformation in the respiratory part of the lung by means of a volume constraint. In combination with a classical monolithic fluid-structure interaction approach, a comprehensive model of the human lung can be established that will be useful to gain new insights into respiratory mechanics in health and disease. To illustrate the validity and versatility of the novel approach, three numerical examples including a patient-specific lung model are presented. The proposed algorithm proves its capability of computing clinically relevant airflow distribution and tissue strain data at a level of detail that is not yet achievable, neither with current imaging techniques nor with existing computational models. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  11. Percolation model with an additional source of disorder

    Science.gov (United States)

    Kundu, Sumanta; Manna, S. S.

    2016-06-01

    The ranges of transmission of the mobiles in a mobile ad hoc network are not uniform in reality. They are affected by the temperature fluctuation in air, obstruction due to the solid objects, even the humidity difference in the environment, etc. How the varying range of transmission of the individual active elements affects the global connectivity in the network may be an important practical question to ask. Here a model of percolation phenomena, with an additional source of disorder, is introduced for a theoretical understanding of this problem. As in ordinary percolation, sites of a square lattice are occupied randomly with probability p . Each occupied site is then assigned a circular disk of random value R for its radius. A bond is defined to be occupied if and only if the radii R1 and R2 of the disks centered at the ends satisfy a certain predefined condition. In a very general formulation, one divides the R1-R2 plane into two regions by an arbitrary closed curve. One defines a point within one region as representing an occupied bond; otherwise it is a vacant bond. The study of three different rules under this general formulation indicates that the percolation threshold always varies continuously. This threshold has two limiting values, one is pc(sq) , the percolation threshold for the ordinary site percolation on the square lattice, and the other is unity. The approach of the percolation threshold to its limiting values are characterized by two exponents. In a special case, all lattice sites are occupied by disks of random radii R ∈{0 ,R0} and a percolation transition is observed with R0 as the control variable, similar to the site occupation probability.

  12. DISPLAY-2: a two-dimensional shallow layer model for dense gas dispersion including complex features.

    Science.gov (United States)

    Venetsanos, A G; Bartzis, J G; Würtz, J; Papailiou, D D

    2003-04-25

    A two-dimensional shallow layer model has been developed to predict dense gas dispersion, under realistic conditions, including complex features such as two-phase releases, obstacles and inclined ground. The model attempts to predict the time and space evolution of the cloud formed after a release of a two-phase pollutant into the atmosphere. The air-pollutant mixture is assumed ideal. The cloud evolution is described mathematically through the Cartesian, two-dimensional, shallow layer conservation equations for mixture mass, mixture momentum in two horizontal directions, total pollutant mass fraction (vapor and liquid) and mixture internal energy. Liquid mass fraction is obtained assuming phase equilibrium. Account is taken in the conservation equations for liquid slip and eventual liquid rainout through the ground. Entrainment of ambient air is modeled via an entrainment velocity model, which takes into account the effects of ground friction, ground heat transfer and relative motion between cloud and surrounding atmosphere. The model additionally accounts for thin obstacles effects in three ways. First a stepwise description of the obstacle is generated, following the grid cell faces, taking into account the corresponding area blockage. Then obstacle drag on the passing cloud is modeled by adding flow resistance terms in the momentum equations. Finally the effect of extra vorticity generation and entrainment enhancement behind obstacles is modeled by adding locally into the entrainment formula without obstacles, a characteristic velocity scale defined from the obstacle pressure drop and the local cloud height.The present model predictions have been compared against theoretical results for constant volume and constant flux gravity currents. It was found that deviations of the predicted cloud footprint area change with time from the theoretical were acceptably small, if one models the frictional forces between cloud and ambient air, neglecting the Richardson

  13. Hyperbolic value addition and general models of animal choice.

    Science.gov (United States)

    Mazur, J E

    2001-01-01

    Three mathematical models of choice--the contextual-choice model (R. Grace, 1994), delay-reduction theory (N. Squires & E. Fantino, 1971), and a new model called the hyperbolic value-added model--were compared in their ability to predict the results from a wide variety of experiments with animal subjects. When supplied with 2 or 3 free parameters, all 3 models made fairly accurate predictions for a large set of experiments that used concurrent-chain procedures. One advantage of the hyperbolic value-added model is that it is derived from a simpler model that makes accurate predictions for many experiments using discrete-trial adjusting-delay procedures. Some results favor the hyperbolic value-added model and delay-reduction theory over the contextual-choice model, but more data are needed from choice situations for which the models make distinctly different predictions.

  14. Validation of gyrokinetic modelling of light impurity transport including rotation in ASDEX Upgrade

    CERN Document Server

    Casson, F J; Angioni, C; Camenen, Y; Dux, R; Fable, E; Fischer, R; Geiger, B; Manas, P; Menchero, L; Tardini, G

    2013-01-01

    Upgraded spectroscopic hardware and an improved impurity concentration calculation allow accurate determination of boron density in the ASDEX Upgrade tokamak. A database of boron measurements is compared to quasilinear and nonlinear gyrokinetic simulations including Coriolis and centrifugal rotational effects over a range of H-mode plasma regimes. The peaking of the measured boron profiles shows a strong anti-correlation with the plasma rotation gradient, via a relationship explained and reproduced by the theory. It is demonstrated that the rotodiffusive impurity flux driven by the rotation gradient is required for the modelling to reproduce the hollow boron profiles at higher rotation gradients. The nonlinear simulations validate the quasilinear approach, and, with the addition of perpendicular flow shear, demonstrate that each symmetry breaking mechanism that causes momentum transport also couples to rotodiffusion. At lower rotation gradients, the parallel compressive convection is required to match the mos...

  15. Tardigrada of Ireland: a review of records and an updated checklist of species including a new addition to the Irish fauna

    Directory of Open Access Journals (Sweden)

    Erica DeMilio

    2016-09-01

    Full Text Available The phylum Tardigrada was not recorded in Ireland until the Clare Island Survey of 1909–1911, with only rare subsequent reports on Irish tardigrade species. In recent decades, significant taxonomic revision has occurred within Tardigrada. This has resulted in the need for a review of all known historical records from Ireland and Northern Ireland in order to produce an updated checklist of valid taxa. The new checklist includes fifty-one tardigrade species and subspecies including a new addition to the Irish fauna reported herein, Echiniscus quadrispinosus quadrispinosus Richters, 1902 from Newtown, Ballyvaughan, Co. Clare.

  16. Tardigrada of Ireland: a review of records and an updated checklist of species including a new addition to the Irish fauna.

    Science.gov (United States)

    DeMilio, Erica; Lawton, Colin; Marley, Nigel J

    2016-01-01

    The phylum Tardigrada was not recorded in Ireland until the Clare Island Survey of 1909-1911, with only rare subsequent reports on Irish tardigrade species. In recent decades, significant taxonomic revision has occurred within Tardigrada. This has resulted in the need for a review of all known historical records from Ireland and Northern Ireland in order to produce an updated checklist of valid taxa. The new checklist includes fifty-one tardigrade species and subspecies including a new addition to the Irish fauna reported herein, Echiniscus quadrispinosus quadrispinosus Richters, 1902 from Newtown, Ballyvaughan, Co. Clare.

  17. An original traffic additional emission model and numerical simulation on a signalized road

    Science.gov (United States)

    Zhu, Wen-Xing; Zhang, Jing-Yu

    2017-02-01

    Based on VSP (Vehicle Specific Power) model traffic real emissions were theoretically classified into two parts: basic emission and additional emission. An original additional emission model was presented to calculate the vehicle's emission due to the signal control effects. Car-following model was developed and used to describe the traffic behavior including cruising, accelerating, decelerating and idling at a signalized intersection. Simulations were conducted under two situations: single intersection and two adjacent intersections with their respective control policy. Results are in good agreement with the theoretical analysis. It is also proved that additional emission model may be used to design the signal control policy in our modern traffic system to solve the serious environmental problems.

  18. A phase-field model for incoherent martensitic transformations including plastic accommodation processes in the austenite

    Science.gov (United States)

    Kundin, J.; Raabe, D.; Emmerich, H.

    2011-10-01

    If alloys undergo an incoherent martensitic transformation, then plastic accommodation and relaxation accompany the transformation. To capture these mechanisms we develop an improved 3D microelastic-plastic phase-field model. It is based on the classical concepts of phase-field modeling of microelastic problems (Chen, L.Q., Wang Y., Khachaturyan, A.G., 1992. Philos. Mag. Lett. 65, 15-23). In addition to these it takes into account the incoherent formation of accommodation dislocations in the austenitic matrix, as well as their inheritance into the martensitic plates based on the crystallography of the martensitic transformation. We apply this new phase-field approach to the butterfly-type martensitic transformation in a Fe-30 wt%Ni alloy in direct comparison to recent experimental data (Sato, H., Zaefferer, S., 2009. Acta Mater. 57, 1931-1937). It is shown that the therein proposed mechanisms of plastic accommodation during the transformation can indeed explain the experimentally observed morphology of the martensitic plates as well as the orientation between martensitic plates and the austenitic matrix. The developed phase-field model constitutes a general simulations approach for different kinds of phase transformation phenomena that inherently include dislocation based accommodation processes. The approach does not only predict the final equilibrium topology, misfit, size, crystallography, and aspect ratio of martensite-austenite ensembles resulting from a transformation, but it also resolves the associated dislocation dynamics and the distribution, and the size of the crystals itself.

  19. a New Model for Describing Evolution and Control of Disaster System Including Instantaneous and Continuous Actions

    Science.gov (United States)

    Chen, Chang-Kun; Li, Zhi; Sun, Yun-Feng

    A new model for describing the disaster system including instantaneous and continuous action synchronously has been developed. The model is composed of three primary parts, that is, the impact from its causative disaster events, stochastic noise of disaster node and self-healing function, and every part is modeled concretely in terms of their characteristics in practice. Some key parameters, namely link appearance probability, retardation coefficient, ultimate repair capacity of government, dynamical modes considering different disaster evolving chains, and the positions of link with the specific performance in disaster network system are involved. Combined with a case study, the proposed model is applied to a certain disaster evolution system, and the influence law of different parameters on disaster evolution process, in disaster networks with instantaneous-action and/or continuous-action, is presented and compared. The results indicate that the destructive impact in the networks by link in continuous action is far greater an order of magnitude than that in instantaneous action. If a link in continuous action emerges in the disaster network system, properties of the causative event for the link, link appearance probability and its position in the network all have a notable influence to the severity of the disaster network. In addition, some peculiar phenomena are also commendably observed in the disaster evolution process based on the model, such as the multipeaks emerging in the destroyed rate number curve for some crisis nodes caused by their various inducing paths together with the relevant retardation coefficients, the existence of the critical value for ultimate repair capacity to recover the disaster node, and so on.

  20. A model predicting fluindione dose requirement in elderly inpatients including genotypes, body weight, and amiodarone.

    Science.gov (United States)

    Moreau, Caroline; Pautas, Eric; Duverlie, Charlotte; Berndt, Celia; Andro, Marion; Mahé, Isabelle; Emmerich, Joseph; Lacut, Karine; Le Gal, Grégoire; Peyron, Isabelle; Gouin-Thibault, Isabelle; Golmard, Jean-Louis; Loriot, Marie-Anne; Siguret, Virginie

    2014-04-01

    Indandione VKAs have been widely used for decades, especially in Eastern Europe and France. Contrary to coumarin VKAs, the relative contribution of individual factors to the indandione-VKA response is poorly known. In the present multicentre study, we sought to develop and validate a model including genetic and non-genetic factors to predict the daily fluindione dose requirement in elderly patients in whom VKA dosing is challenging. We prospectively recorded clinical and therapeutic data in 230 Caucasian inpatients mean aged 85 ± 6 years, who had reached international normalized ratio stabilisation (range 2.0-3.0) on fluindione. In the derivation cohort (n=156), we analysed 13 polymorphisms in seven genes potentially involved in the pharmacological effect or vitamin-K cycle (VKORC1, CYP4F2, EPHX1) and fluindione metabolism/transport (CYP2C9, CYP2C19, CYP3A5, ABCB1). We built a regression model incorporating non-genetic and genetic data and evaluated the model performances in a separate cohort (n=74).Body-weight, amiodarone intake, VKORC1, CYP4F2, ABCB1 genotypes were retained in the final model, accounting for 31.5% of dose variability. None influence of CYP2C9 was observed. Our final model showed good performances: in 83.3% of the validation cohort patients, the dose was accurately predicted within 5 mg, i.e.the usual step used for adjusting fluindione dosage. In conclusion, in addition to body-weight and amiodarone-intake, pharmacogenetic factors (VKORC1, CYP4F2, ABCB1) related to the pharmacodynamic effect and transport of fluindione significantly influenced the dose requirement in elderly patients while CYP2C9 did not. Studies are required to know whether fluindione could be an alternative VKA in carriers of polymorphic CYP2C9 alleles, hypersensitive to coumarins.

  1. Additive manufacturing for consumer-centric business models

    DEFF Research Database (Denmark)

    Bogers, Marcel; Hadar, Ronen; Bilberg, Arne

    2016-01-01

    and capturing value. In this paper, we explore the implications that AM technologies have for manufacturing systems in the new business models that they enable. In particular, we consider how a consumer goods manufacturer can organize the operations of a more open business model when moving from a manufacturer...

  2. Hybrid discrete-continuum modeling for transport, biofilm development and solid restructuring including electrostatic effects

    Science.gov (United States)

    Prechtel, Alexander; Ray, Nadja; Rupp, Andreas

    2017-04-01

    We want to present an approach for the mathematical, mechanistic modeling and numerical treatment of processes leading to the formation, stability, and turnover of soil micro-aggregates. This aims at deterministic aggregation models including detailed mechanistic pore-scale descriptions to account for the interplay of geochemistry and microbiology, and the link to soil functions as, e.g., the porosity. We therefore consider processes at the pore scale and the mesoscale (laboratory scale). At the pore scale transport by diffusion, advection, and drift emerging from electric forces can be taken into account, in addition to homogeneous and heterogeneous reactions of species. In the context of soil micro-aggregates the growth of biofilms or other glueing substances as EPS (extracellular polymeric substances) is important and affects the structure of the pore space in space and time. This model is upscaled mathematically in the framework of (periodic) homogenization to transfer it to the mesoscale resulting in effective coefficients/parameters there. This micro-macro model thus couples macroscopic equations that describe the transport and fluid flow at the scale of the porous medium (mesoscale) with averaged time- and space-dependent coefficient functions. These functions may be explicitly computed by means of auxiliary cell problems (microscale). Finally, the pore space in which the cell problems are defined is time and space dependent and its geometry inherits information from the transport equation's solutions. The microscale problems rely on versatile combinations of cellular automata and discontiuous Galerkin methods while on the mesoscale mixed finite elements are used. The numerical simulations allow to study the interplay between these processes.

  3. Additive Manufacturing of Anatomical Models from Computed Tomography Scan Data.

    Science.gov (United States)

    Gür, Y

    2014-12-01

    The purpose of the study presented here was to investigate the manufacturability of human anatomical models from Computed Tomography (CT) scan data via a 3D desktop printer which uses fused deposition modelling (FDM) technology. First, Digital Imaging and Communications in Medicine (DICOM) CT scan data were converted to 3D Standard Triangle Language (STL) format by using In Vaselius digital imaging program. Once this STL file is obtained, a 3D physical version of the anatomical model can be fabricated by a desktop 3D FDM printer. As a case study, a patient's skull CT scan data was considered, and a tangible version of the skull was manufactured by a 3D FDM desktop printer. During the 3D printing process, the skull was built using acrylonitrile-butadiene-styrene (ABS) co-polymer plastic. The printed model showed that the 3D FDM printing technology is able to fabricate anatomical models with high accuracy. As a result, the skull model can be used for preoperative surgical planning, medical training activities, implant design and simulation to show the potential of the FDM technology in medical field. It will also improve communication between medical stuff and patients. Current result indicates that a 3D desktop printer which uses FDM technology can be used to obtain accurate anatomical models.

  4. Quantum Ring-Polymer Contraction Method: Including nuclear quantum effects at no additional computational cost in comparison to ab-initio molecular dynamics

    CERN Document Server

    John, Chris; Habershon, Scott; Kühne, Thomas D

    2015-01-01

    We present a simple and accurate computational method, which facilitates ab-initio path-integral molecular dynamics simulations, where the quantum mechanical nature of the nuclei is explicitly taken into account, at essentially no additional computational cost in comparison to the corresponding calculation using classical nuclei. The predictive power of the proposed quantum ring-polymer contraction method is demonstrated by computing various static and dynamic properties of liquid water at ambient conditions. This development permits to routinely include nuclear quantum effects in ab-initio molecular dynamics simulations.

  5. Estimation of additive and dominance variance for reproductive traits from different models in Duroc purebred

    Directory of Open Access Journals (Sweden)

    Talerngsak Angkuraseranee

    2010-05-01

    Full Text Available The additive and dominance genetic variances of 5,801 Duroc reproductive and growth records were estimated usingBULPF90 PC-PACK. Estimates were obtained for number born alive (NBA, birth weight (BW, number weaned (NW, andweaning weight (WW. Data were analyzed using two mixed model equations. The first model included fixed effects andrandom effects identifying inbreeding depression, additive gene effect and permanent environments effects. The secondmodel was similar to the first model, but included the dominance genotypic effect. Heritability estimates of NBA, BW, NWand WW from the two models were 0.1558/0.1716, 0.1616/0.1737, 0.0372/0.0874 and 0.1584/0.1516 respectively. Proportionsof dominance effect to total phenotypic variance from the dominance model were 0.1024, 0.1625, 0.0470, and 0.1536 for NBA,BW, NW and WW respectively. Dominance effects were found to have sizable influence on the litter size traits analyzed.Therefore, genetic evaluation with the dominance model (Model 2 is found more appropriate than the animal model (Model 1.

  6. Modeling continuous self-report measures of perceived emotion using generalized additive mixed models.

    Science.gov (United States)

    McKeown, Gary J; Sneddon, Ian

    2014-03-01

    Emotion research has long been dominated by the "standard method" of displaying posed or acted static images of facial expressions of emotion. While this method has been useful, it is unable to investigate the dynamic nature of emotion expression. Although continuous self-report traces have enabled the measurement of dynamic expressions of emotion, a consensus has not been reached on the correct statistical techniques that permit inferences to be made with such measures. We propose generalized additive models and generalized additive mixed models as techniques that can account for the dynamic nature of such continuous measures. These models allow us to hold constant shared components of responses that are due to perceived emotion across time, while enabling inference concerning linear differences between groups. The generalized additive mixed model approach is preferred, as it can account for autocorrelation in time series data and allows emotion decoding participants to be modeled as random effects. To increase confidence in linear differences, we assess the methods that address interactions between categorical variables and dynamic changes over time. In addition, we provide comments on the use of generalized additive models to assess the effect size of shared perceived emotion and discuss sample sizes. Finally, we address additional uses, the inference of feature detection, continuous variable interactions, and measurement of ambiguity.

  7. Non-additive model for specific heat of electrons

    Science.gov (United States)

    Anselmo, D. H. A. L.; Vasconcelos, M. S.; Silva, R.; Mello, V. D.

    2016-10-01

    By using non-additive Tsallis entropy we demonstrate numerically that one-dimensional quasicrystals, whose energy spectra are multifractal Cantor sets, are characterized by an entropic parameter, and calculate the electronic specific heat, where we consider a non-additive entropy Sq. In our method we consider an energy spectra calculated using the one-dimensional tight binding Schrödinger equation, and their bands (or levels) are scaled onto the [ 0 , 1 ] interval. The Tsallis' formalism is applied to the energy spectra of Fibonacci and double-period one-dimensional quasiperiodic lattices. We analytically obtain an expression for the specific heat that we consider to be more appropriate to calculate this quantity in those quasiperiodic structures.

  8. Richly parameterized linear models additive, time series, and spatial models using random effects

    CERN Document Server

    Hodges, James S

    2013-01-01

    A First Step toward a Unified Theory of Richly Parameterized Linear ModelsUsing mixed linear models to analyze data often leads to results that are mysterious, inconvenient, or wrong. Further compounding the problem, statisticians lack a cohesive resource to acquire a systematic, theory-based understanding of models with random effects.Richly Parameterized Linear Models: Additive, Time Series, and Spatial Models Using Random Effects takes a first step in developing a full theory of richly parameterized models, which would allow statisticians to better understand their analysis results. The aut

  9. High performance computation of landscape genomic models including local indicators of spatial association.

    Science.gov (United States)

    Stucki, S; Orozco-terWengel, P; Forester, B R; Duruz, S; Colli, L; Masembe, C; Negrini, R; Landguth, E; Jones, M R; Bruford, M W; Taberlet, P; Joost, S

    2016-11-01

    With the increasing availability of both molecular and topo-climatic data, the main challenges facing landscape genomics - that is the combination of landscape ecology with population genomics - include processing large numbers of models and distinguishing between selection and demographic processes (e.g. population structure). Several methods address the latter, either by estimating a null model of population history or by simultaneously inferring environmental and demographic effects. Here we present samβada, an approach designed to study signatures of local adaptation, with special emphasis on high performance computing of large-scale genetic and environmental data sets. samβada identifies candidate loci using genotype-environment associations while also incorporating multivariate analyses to assess the effect of many environmental predictor variables. This enables the inclusion of explanatory variables representing population structure into the models to lower the occurrences of spurious genotype-environment associations. In addition, samβada calculates local indicators of spatial association for candidate loci to provide information on whether similar genotypes tend to cluster in space, which constitutes a useful indication of the possible kinship between individuals. To test the usefulness of this approach, we carried out a simulation study and analysed a data set from Ugandan cattle to detect signatures of local adaptation with samβada, bayenv, lfmm and an FST outlier method (FDIST approach in arlequin) and compare their results. samβada - an open source software for Windows, Linux and Mac OS X available at http://lasig.epfl.ch/sambada - outperforms other approaches and better suits whole-genome sequence data processing.

  10. The additive hazards model with high-dimensional regressors

    DEFF Research Database (Denmark)

    Martinussen, Torben; Scheike, Thomas

    2009-01-01

    model. A standard PLS algorithm can also be constructed, but it turns out that the resulting predictor can only be related to the original covariates via time-dependent coefficients. The methods are applied to a breast cancer data set with gene expression recordings and to the well known primary biliary...

  11. Multiple Imputation of Predictor Variables Using Generalized Additive Models

    NARCIS (Netherlands)

    de Jong, Roel; van Buuren, Stef; Spiess, Martin

    2016-01-01

    The sensitivity of multiple imputation methods to deviations from their distributional assumptions is investigated using simulations, where the parameters of scientific interest are the coefficients of a linear regression model, and values in predictor variables are missing at random. The performanc

  12. ATEFlap aerodynamic model, a dynamic stall model including the effects of trailing edge flap deflection

    Energy Technology Data Exchange (ETDEWEB)

    Bergami, L.; Gaunaa, M.

    2012-02-15

    The report presents the ATEFlap aerodynamic model, which computes the unsteady lift, drag and moment on a 2D airfoil section equipped with Adaptive Trailing Edge Flap. The model captures the unsteady response related to the effects of the vorticity shed into the wake, and the dynamics of flow separation a thin-airfoil potential flow model is merged with a dynamic stall model of the Beddoes-Leishmann type. The inputs required by the model are steady data for lift, drag, and moment coefficients as function of angle of attack and flap deflection. Further steady data used by the Beddoes- Leishmann dynamic stall model are computed in an external preprocessor application, which gives the user the possibility to verify, and eventually correct, the steady data passed to the aerodynamic model. The ATEFlap aerodynamic model is integrated in the aeroelastic simulation tool HAWC2, thus al- lowing to simulate the response of a wind turbine with trailing edge flaps on the rotor. The algorithms used by the preprocessor, and by aerodynamic model are presented, and modifications to previous implementations of the aerodynamic model are briefly discussed. The performance and the validity of the model are verified by comparing the dynamic response computed by the ATEFlap with solutions from CFD simulations. (Author)

  13. A Two-Account Life Insurance Model for Scenario-Based Valuation Including Event Risk

    DEFF Research Database (Denmark)

    Jensen, Ninna Reitzel; Schomacker, Kristian Juul

    2015-01-01

    Using a two-account model with event risk, we model life insurance contracts taking into account both guaranteed and non-guaranteed payments in participating life insurance as well as in unit-linked insurance. Here, event risk is used as a generic term for life insurance events, such as death......, disability, etc. In our treatment of participating life insurance, we have special focus on the bonus schemes “consolidation” and “additional benefits”, and one goal is to formalize how these work and interact. Another goal is to describe similarities and differences between participating life insurance...... model by conducting scenario analysis based on Monte Carlo simulation, but the model applies to scenarios in general and to worst-case and best-estimate scenarios in particular. In addition to easy computations, our model offers a common framework for the valuation of life insurance payments across...

  14. Importance of global aerosol modeling including secondary organic aerosol formed from monoterpene

    OpenAIRE

    Goto, Daisuke; Takemura, Toshihiko; Nakajima, Teruyuki

    2008-01-01

    A global three-dimensional aerosol transport-radiation model, coupled to an atmospheric general circulation model (AGCM), has been extended to improve the model process for organic aerosols, particularly secondary organic aerosols (SOA), and to estimate SOA contributions to direct and indirect radiative effects. Because the SOA formation process is complicated and unknown, the results in different model simulations include large differences. In this work, we simulate SOA production assuming v...

  15. MODEL ANALYSIS AND PARAMETER EXTRACTION FOR MOS CAPACITOR INCLUDING QUANTUM MECHANICAL EFFECTS

    Institute of Scientific and Technical Information of China (English)

    Hai-yan Jiang; Ping-wen Zhang

    2006-01-01

    The high frequency CV curves of MOS capacitor have been studied. It is shown that semiclassical model is a good approximation to quantum model and approaches to classical model when the oxide layer is thick. This conclusion provides us an efficient (semiclassical) model including quantum mechanical effects to do parameter extraction for ultrathi noxide device. Here the effective extracting strategy is designed and numerical experiments demonstrate the validity of the strategy.

  16. Vector generalized linear and additive models with an implementation in R

    CERN Document Server

    Yee, Thomas W

    2015-01-01

    This book presents a statistical framework that expands generalized linear models (GLMs) for regression modelling. The framework shared in this book allows analyses based on many semi-traditional applied statistics models to be performed as a coherent whole. This is possible through the approximately half-a-dozen major classes of statistical models included in the book and the software infrastructure component, which makes the models easily operable.    The book’s methodology and accompanying software (the extensive VGAM R package) are directed at these limitations, and this is the first time the methodology and software are covered comprehensively in one volume. Since their advent in 1972, GLMs have unified important distributions under a single umbrella with enormous implications. The demands of practical data analysis, however, require a flexibility that GLMs do not have. Data-driven GLMs, in the form of generalized additive models (GAMs), are also largely confined to the exponential family. This book ...

  17. Additional interfacial force in lattice Boltzmann models for incompressible multiphase flows

    CERN Document Server

    Li, Q; Gao, Y J

    2011-01-01

    The existing lattice Boltzmann models for incompressible multiphase flows are mostly constructed with two distribution functions, one is the order parameter distribution function, which is used to track the interface between different phases, and the other is the pressure distribution function for solving the velocity field. In this brief report, it is shown that in these models the recovered momentum equation is inconsistent with the target one: an additional interfacial force is included in the recovered momentum equation. The effects of the additional force are investigated by numerical simulations of droplet splashing on a thin liquid film and falling droplet under gravity. In the former test, it is found that the formation and evolution of secondary droplets are greatly affected, while in the latter the additional force is found to increase the falling velocity and limit the stretch of the droplet.

  18. A methodology for including wall roughness effects in k-ε low-Reynolds turbulence models

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosini, W., E-mail: walter.ambrosini@ing.unipi.it; Pucciarelli, A.; Borroni, I.

    2015-05-15

    Highlights: • A model for taking into account wall roughness in low-Reynolds k-ε models is presented. • The model is subjected to a first validation to show its potential in general applications. • The application of the model in predicting heat transfer to supercritical fluids is also discussed. - Abstract: A model accounting for wall roughness effects in k-ε low-Reynolds turbulence models is described in the present paper. In particular, the introduction in the transport equations of k and ε of additional source terms related to roughness, based on simple assumptions and dimensional relationships, is proposed. An objective of the present paper, in addition to obtaining more realistic predictions of wall friction, is the application of the proposed model to the study of heat transfer to supercritical fluids. A first validation of the model is reported. The model shows the capability of predicting, at least qualitatively, some of the most important trends observed when dealing with rough pipes in very different flow conditions. Qualitative comparisons with some DNS data available in literature are also performed. Further analyses provided promising results concerning the ability of the model in reproducing the trend of friction factor when varying the flow conditions, though improvements are necessary for achieving better quantitative accuracy. First applications of the model in simulating heat transfer to supercritical fluids are also described, showing the capability of the model to affect the predictions of these heat transfer phenomena, in particular in the vicinity of the pseudo-critical conditions. A more extended application of the model to relevant deteriorated heat transfer conditions will clarify the usefulness of this modelling methodology in improving predictions of these difficult phenomena. Whatever the possible success in this particular application that motivated its development, this approach suggests a general methodology for accounting

  19. A finite element model of the face including an orthotropic skin model under in vivo tension.

    Science.gov (United States)

    Flynn, Cormac; Stavness, Ian; Lloyd, John; Fels, Sidney

    2015-01-01

    Computer models of the human face have the potential to be used as powerful tools in surgery simulation and animation development applications. While existing models accurately represent various anatomical features of the face, the representation of the skin and soft tissues is very simplified. A computer model of the face is proposed in which the skin is represented by an orthotropic hyperelastic constitutive model. The in vivo tension inherent in skin is also represented in the model. The model was tested by simulating several facial expressions by activating appropriate orofacial and jaw muscles. Previous experiments calculated the change in orientation of the long axis of elliptical wounds on patients' faces for wide opening of the mouth and an open-mouth smile (both 30(o)). These results were compared with the average change of maximum principal stress direction in the skin calculated in the face model for wide opening of the mouth (18(o)) and an open-mouth smile (25(o)). The displacements of landmarks on the face for four facial expressions were compared with experimental measurements in the literature. The corner of the mouth in the model experienced the largest displacement for each facial expression (∼11-14 mm). The simulated landmark displacements were within a standard deviation of the measured displacements. Increasing the skin stiffness and skin tension generally resulted in a reduction in landmark displacements upon facial expression.

  20. Convenient synthesis of energetic polynitro materials including (NO2)3CCH2CH2NH3-salts via Michael addition of trinitromethane.

    Science.gov (United States)

    Axthammer, Quirin J; Klapötke, Thomas M; Krumm, Burkhard; Scharf, Regina; Unger, Cornelia C

    2016-12-21

    The nucleophilic Michael addition of nitroform with acrylamide creates a variety of energetic products. Several interesting compounds with a trinitromethyl group were synthesized, among them salts containing the trinitropropylammonium cation, [(NO2)3CCH2CH2NH3]X. Owing to their positive oxygen balance, the suitability of these compounds as potential high-energy dense oxidizers (HEDOs) in energetic formulations was investigated and discussed. Furthermore, numerous important and reactive compounds for the continuing synthesis of molecules with a high oxygen balance are presented. All compounds were fully characterized, including multinuclear NMR spectroscopy, vibrational analysis (IR, Raman), elemental analysis, as well as single crystal X-ray diffraction. Thermal stabilities were studied using differential scanning calorimetry and sensitivity data against friction, impact and electrostatic discharge were collected. The energies of formation were calculated using Gaussian 09 and energetic properties, such as the specific impulse and detonation velocity, were predicted with the EXPLO5 (V6.02) computer code.

  1. Hot DA white dwarf model atmosphere calculations: Including improved Ni PI cross sections

    CERN Document Server

    Preval, S P; Badnell, N R; Hubeny, I; Holberg, J B

    2016-01-01

    To calculate realistic models of objects with Ni in their atmospheres, accurate atomic data for the relevant ionization stages needs to be included in model atmosphere calculations. In the context of white dwarf stars, we investigate the effect of changing the Ni {\\sc iv}-{\\sc vi} bound-bound and bound-free atomic data has on model atmosphere calculations. Models including PICS calculated with {\\sc autostructure} show significant flux attenuation of up to $\\sim 80$\\% shortward of 180\\AA\\, in the EUV region compared to a model using hydrogenic PICS. Comparatively, models including a larger set of Ni transitions left the EUV, UV, and optical continua unaffected. We use models calculated with permutations of this atomic data to test for potential changes to measured metal abundances of the hot DA white dwarf G191-B2B. Models including {\\sc autostructure} PICS were found to change the abundances of N and O by as much as $\\sim 22$\\% compared to models using hydrogenic PICS, but heavier species were relatively unaf...

  2. Mathematical Model of Thyristor Inverter Including a Series-parallel Resonant Circuit

    Directory of Open Access Journals (Sweden)

    Miroslaw Luft

    2008-01-01

    Full Text Available The article presents a mathematical model of thyristor inverter including a series-parallel resonant circuit with theaid of state variable method. Maple procedures are used to compute current and voltage waveforms in the inverter.

  3. A Verilog-A large signal model for InP DHBT including thermal effects

    Science.gov (United States)

    Yuxia, Shi; Zhi, Jin; Zhijian, Pan; Yongbo, Su; Yuxiong, Cao; Yan, Wang

    2013-06-01

    A large signal model for InP/InGaAs double heterojunction bipolar transistors including thermal effects has been reported, which demonstrated good agreements of simulations with measurements. On the basis of the previous model in which the double heterojunction effect, current blocking effect and high current effect in current expression are considered, the effect of bandgap narrowing with temperature has been considered in transport current while a formula for model parameters as a function of temperature has been developed. This model is implemented by Verilog-A and embedded in ADS. The proposed model is verified with DC and large signal measurements.

  4. Numerical Acoustic Models Including Viscous and Thermal losses: Review of Existing and New Methods

    DEFF Research Database (Denmark)

    Andersen, Peter Risby; Cutanda Henriquez, Vicente; Aage, Niels

    2017-01-01

    This work presents an updated overview of numerical methods including acoustic viscous and thermal losses. Numerical modelling of viscothermal losses has gradually become more important due to the general trend of making acoustic devices smaller. Not including viscothermal acoustic losses in such...

  5. Experimental model and analytic solution for real-time observation of vehicle's additional steer angle

    Science.gov (United States)

    Zhang, Xiaolong; Li, Liang; Pan, Deng; Cao, Chengmao; Song, Jian

    2014-03-01

    The current research of real-time observation for vehicle roll steer angle and compliance steer angle(both of them comprehensively referred as the additional steer angle in this paper) mainly employs the linear vehicle dynamic model, in which only the lateral acceleration of vehicle body is considered. The observation accuracy resorting to this method cannot meet the requirements of vehicle real-time stability control, especially under extreme driving conditions. The paper explores the solution resorting to experimental method. Firstly, a multi-body dynamic model of a passenger car is built based on the ADAMS/Car software, whose dynamic accuracy is verified by the same vehicle's roadway test data of steady static circular test. Based on this simulation platform, several influencing factors of additional steer angle under different driving conditions are quantitatively analyzed. Then ɛ-SVR algorithm is employed to build the additional steer angle prediction model, whose input vectors mainly include the sensor information of standard electronic stability control system(ESC). The method of typical slalom tests and FMVSS 126 tests are adopted to make simulation, train model and test model's generalization performance. The test result shows that the influence of lateral acceleration on additional steer angle is maximal (the magnitude up to 1°), followed by the longitudinal acceleration-deceleration and the road wave amplitude (the magnitude up to 0.3°). Moreover, both the prediction accuracy and the calculation real-time of the model can meet the control requirements of ESC. This research expands the accurate observation methods of the additional steer angle under extreme driving conditions.

  6. Choosing components in the additive main effect and multiplicative interaction (AMMI models

    Directory of Open Access Journals (Sweden)

    Dias Carlos Tadeu dos Santos

    2006-01-01

    Full Text Available The additive main effect and multiplicative interaction (AMMI models allows analysts to detect interactions between rows and columns in a two-way table. However, there are many methods proposed in the literature to determine the number of multiplicative components to include in the AMMI model. These methods typically give different results for any particular data set, so the user needs some guidance as to which methods to use. In this paper we compare four commonly used methods using simulated data based on real experiments, and provide some general recommendations.

  7. Age-period-cohort models using smoothing splines: a generalized additive model approach.

    Science.gov (United States)

    Jiang, Bei; Carriere, Keumhee C

    2014-02-20

    Age-period-cohort (APC) models are used to analyze temporal trends in disease or mortality rates, dealing with linear dependency among associated effects of age, period, and cohort. However, the nature of sparseness in such data has severely limited the use of APC models. To deal with these practical limitations and issues, we advocate cubic smoothing splines. We show that the methods of estimable functions proposed in the framework of generalized linear models can still be considered to solve the non-identifiability problem when the model fitting is within the framework of generalized additive models with cubic smoothing splines. Through simulation studies, we evaluate the performance of the cubic smoothing splines in terms of the mean squared errors of estimable functions. Our results support the use of cubic smoothing splines for APC modeling with sparse but unaggregated data from a Lexis diagram.

  8. Neurologic Outcome After Resection of Parietal Lobe Including Primary Somatosensory Cortex: Implications of Additional Resection of Posterior Parietal Cortex.

    Science.gov (United States)

    Kim, Young-Hoon; Kim, June Sic; Lee, Sang Kun; Chung, Chun Kee

    2017-10-01

    Postoperative neurologic outcomes after primary somatosensory cortex (S1) resection have not been well documented. This study was designed to evaluate the neurologic deterioration that follows resection of the S1 areas and to assess the risk factors associated with these morbidities. We reviewed 48 consecutive patients with medically intractable epilepsy who underwent resection of the S1 and/or the adjacent cortex. The 48 patients were categorized into 4 groups according to the resected area as seen on postoperative magnetic resonance images: group 1 (resection of S1 only; n = 4), 2 (the posterior parietal cortex [PPC] only; n = 24), 3 (S1 and PPC; n = 10), and 4 (S1 and precentral gyrus; n = 10). After the resection of S1 areas, 19 patients (40%) experienced neurologic worsening, including 6 (13%) with permanent and 13 (27%) with transient deficits. Patients with permanent deficits included 2 with motor dysphasia, 1 with dysesthesia, 2 with equilibrium impairments, and 1 with fine movement disturbance of the hand. The overall and permanent neurologic risks were 25% and 0% in group 1, 17% and 4% in group 2, 80% and 20% in group 3, and 60% and 30% in group 4, respectively. Multivariate analysis determined that the resection of both S1 and PPC was the only significant risk factor for neurologic deficits (P = 0.002). The neurologic risk of the resection of S1 and/or its adjacent cortical areas was 40%. The additional resection of the PPC was significantly associated with the development of postoperative neurologic impairments. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Formation and reduction of carcinogenic furan in various model systems containing food additives.

    Science.gov (United States)

    Kim, Jin-Sil; Her, Jae-Young; Lee, Kwang-Geun

    2015-12-15

    The aim of this study was to analyse and reduce furan in various model systems. Furan model systems consisting of monosaccharides (0.5M glucose and ribose), amino acids (0.5M alanine and serine) and/or 1.0M ascorbic acid were heated at 121°C for 25 min. The effects of food additives (each 0.1M) such as metal ions (iron sulphate, magnesium sulphate, zinc sulphate and calcium sulphate), antioxidants (BHT and BHA), and sodium sulphite on the formation of furan were measured. The level of furan formed in the model systems was 6.8-527.3 ng/ml. The level of furan in the model systems of glucose/serine and glucose/alanine increased 7-674% when food additives were added. In contrast, the level of furan decreased by 18-51% in the Maillard reaction model systems that included ribose and alanine/serine with food additives except zinc sulphate.

  10. Catalytic conversion of lignin pyrolysis model compound- guaiacol and its kinetic model including coke formation

    Science.gov (United States)

    Zhang, Huiyan; Wang, Yun; Shao, Shanshan; Xiao, Rui

    2016-11-01

    Lignin is the most difficult to be converted and most easy coking component in biomass catalytic pyrolysis to high-value liquid fuels and chemicals. Catalytic conversion of guaiacol as a lignin model compound was conducted in a fixed-bed reactor over ZSM-5 to investigate its conversion and coking behaviors. The effects of temperature, weight hourly space velocity (WHSV) and partial pressure on product distribution were studied. The results show the maximum aromatic carbon yield of 28.55% was obtained at temperature of 650 °C, WHSV of 8 h‑1 and partial pressure of 2.38 kPa, while the coke carbon yield was 19.55%. The reaction pathway was speculated to be removing methoxy group to form phenols with further aromatization to form aromatics. The amount of coke increased with increasing reaction time. The surface area and acidity of catalysts declined as coke formed on the acid sites and blocked the pore channels, which led to the decrease of aromatic yields. Finally, a kinetic model of guaiacol catalytic conversion considering coke deposition was built based on the above reaction pathway to properly predict product distribution. The experimental and model predicting data agreed well. The correlation coefficient of all equations were all higher than 0.90.

  11. Including operational data in QMRA model: development and impact of model inputs.

    Science.gov (United States)

    Jaidi, Kenza; Barbeau, Benoit; Carrière, Annie; Desjardins, Raymond; Prévost, Michèle

    2009-03-01

    A Monte Carlo model, based on the Quantitative Microbial Risk Analysis approach (QMRA), has been developed to assess the relative risks of infection associated with the presence of Cryptosporidium and Giardia in drinking water. The impact of various approaches for modelling the initial parameters of the model on the final risk assessments is evaluated. The Monte Carlo simulations that we performed showed that the occurrence of parasites in raw water was best described by a mixed distribution: log-Normal for concentrations > detection limit (DL), and a uniform distribution for concentrations risks significantly. The mean annual risks for conventional treatment are: 1.97E-03 (removal credit adjusted by log parasite = log spores), 1.58E-05 (log parasite = 1.7 x log spores) or 9.33E-03 (regulatory credits based on the turbidity measurement in filtered water). Using full scale validated SCADA data, the simplified calculation of CT performed at the plant was shown to largely underestimate the risk relative to a more detailed CT calculation, which takes into consideration the downtime and system failure events identified at the plant (1.46E-03 vs. 3.93E-02 for the mean risk).

  12. Combining an additive and tree-based regression model simultaneously: STIMA

    NARCIS (Netherlands)

    Dusseldorp, E.; Conversano, C.; Os, B.J. van

    2010-01-01

    Additive models and tree-based regression models are two main classes of statistical models used to predict the scores on a continuous response variable. It is known that additive models become very complex in the presence of higher order interaction effects, whereas some tree-based models, such as

  13. Modeling of Ti-W Solidification Microstructures Under Additive Manufacturing Conditions

    Science.gov (United States)

    Rolchigo, Matthew R.; Mendoza, Michael Y.; Samimi, Peyman; Brice, David A.; Martin, Brian; Collins, Peter C.; LeSar, Richard

    2017-07-01

    Additive manufacturing (AM) processes have many benefits for the fabrication of alloy parts, including the potential for greater microstructural control and targeted properties than traditional metallurgy processes. To accelerate utilization of this process to produce such parts, an effective computational modeling approach to identify the relationships between material and process parameters, microstructure, and part properties is essential. Development of such a model requires accounting for the many factors in play during this process, including laser absorption, material addition and melting, fluid flow, various modes of heat transport, and solidification. In this paper, we start with a more modest goal, to create a multiscale model for a specific AM process, Laser Engineered Net Shaping (LENS™), which couples a continuum-level description of a simplified beam melting problem (coupling heat absorption, heat transport, and fluid flow) with a Lattice Boltzmann-cellular automata (LB-CA) microscale model of combined fluid flow, solute transport, and solidification. We apply this model to a binary Ti-5.5 wt pct W alloy and compare calculated quantities, such as dendrite arm spacing, with experimental results reported in a companion paper.

  14. Nonlinear Modeling of a High Precision Servo Injection Molding Machine Including Novel Molding Approach

    Institute of Scientific and Technical Information of China (English)

    何雪松; 王旭永; 冯正进; 章志新; 杨钦廉

    2003-01-01

    A nonlinear mathematical model of the injection molding process for electrohydraulic servo injection molding machine (IMM) is developed.It was found necessary to consider the characteristics of asymmetric cylinder for electrohydraulic servo IMM.The model is based on the dynamics of the machine including servo valve,asymmetric cylinder and screw,and the non-Newtonian flow behavior of polymer melt in injection molding is also considered.The performance of the model was evaluated based on novel approach of molding - injection and compress molding,and the results of simulation and experimental data demonstrate the effectiveness of the model.

  15. a Better Description of Liquid Jet Breakup Using a Spatial Model Including Viscous Effects.

    Science.gov (United States)

    Hammerschlag, William Brian

    Theoretical models describing the operation and disintegration of a liquid jet are often based on an approximate solution of an inviscid jet in the temporal frame of reference. These models provide only a fair first order prediction of growth rate and breakoff length, and are based solely on a surface tension induced instability. A spatial model yielding jet growth rate and including both jet and surrounding atmosphere viscosity and density is now developed. This model is seen to reproduce all the features and limitations of the Weber viscous jet theory. When tested against experiments of water, water and glycerol mixes and binary eutectic tin/lead solder, only fair agreement is observed.

  16. A Two-Account Life Insurance Model for Scenario-Based Valuation Including Event Risk

    Directory of Open Access Journals (Sweden)

    Ninna Reitzel Jensen

    2015-06-01

    Full Text Available Using a two-account model with event risk, we model life insurance contracts taking into account both guaranteed and non-guaranteed payments in participating life insurance as well as in unit-linked insurance. Here, event risk is used as a generic term for life insurance events, such as death, disability, etc. In our treatment of participating life insurance, we have special focus on the bonus schemes “consolidation” and “additional benefits”, and one goal is to formalize how these work and interact. Another goal is to describe similarities and differences between participating life insurance and unit-linked insurance. By use of a two-account model, we are able to illustrate general concepts without making the model too abstract. To allow for complicated financial markets without dramatically increasing the mathematical complexity, we focus on economic scenarios. We illustrate the use of our model by conducting scenario analysis based on Monte Carlo simulation, but the model applies to scenarios in general and to worst-case and best-estimate scenarios in particular. In addition to easy computations, our model offers a common framework for the valuation of life insurance payments across product types. This enables comparison of participating life insurance products and unit-linked insurance products, thus building a bridge between the two different ways of formalizing life insurance products. Finally, our model distinguishes itself from the existing literature by taking into account the Markov model for the state of the policyholder and, hereby, facilitating event risk.

  17. Generalized Additive Mixed-Models for Pharmacology Using Integrated Discrete Multiple Organ Co-Culture

    Science.gov (United States)

    Ingersoll, Thomas; Cole, Stephanie; Madren-Whalley, Janna; Booker, Lamont; Dorsey, Russell; Li, Albert; Salem, Harry

    2016-01-01

    Integrated Discrete Multiple Organ Co-culture (IDMOC) is emerging as an in-vitro alternative to in-vivo animal models for pharmacology studies. IDMOC allows dose-response relationships to be investigated at the tissue and organoid levels, yet, these relationships often exhibit responses that are far more complex than the binary responses often measured in whole animals. To accommodate departure from binary endpoints, IDMOC requires an expansion of analytic techniques beyond simple linear probit and logistic models familiar in toxicology. IDMOC dose-responses may be measured at continuous scales, exhibit significant non-linearity such as local maxima or minima, and may include non-independent measures. Generalized additive mixed-modeling (GAMM) provides an alternative description of dose-response that relaxes assumptions of independence and linearity. We compared GAMMs to traditional linear models for describing dose-response in IDMOC pharmacology studies. PMID:27110941

  18. Generalized Additive Mixed-Models for Pharmacology Using Integrated Discrete Multiple Organ Co-Culture.

    Directory of Open Access Journals (Sweden)

    Thomas Ingersoll

    Full Text Available Integrated Discrete Multiple Organ Co-culture (IDMOC is emerging as an in-vitro alternative to in-vivo animal models for pharmacology studies. IDMOC allows dose-response relationships to be investigated at the tissue and organoid levels, yet, these relationships often exhibit responses that are far more complex than the binary responses often measured in whole animals. To accommodate departure from binary endpoints, IDMOC requires an expansion of analytic techniques beyond simple linear probit and logistic models familiar in toxicology. IDMOC dose-responses may be measured at continuous scales, exhibit significant non-linearity such as local maxima or minima, and may include non-independent measures. Generalized additive mixed-modeling (GAMM provides an alternative description of dose-response that relaxes assumptions of independence and linearity. We compared GAMMs to traditional linear models for describing dose-response in IDMOC pharmacology studies.

  19. Including hydrological self-regulating processes in peatland models: Effects on peatmoss drought projections.

    Science.gov (United States)

    Nijp, Jelmer J; Metselaar, Klaas; Limpens, Juul; Teutschbein, Claudia; Peichl, Matthias; Nilsson, Mats B; Berendse, Frank; van der Zee, Sjoerd E A T M

    2017-02-15

    The water content of the topsoil is one of the key factors controlling biogeochemical processes, greenhouse gas emissions and biosphere - atmosphere interactions in many ecosystems, particularly in northern peatlands. In these wetland ecosystems, the water content of the photosynthetic active peatmoss layer is crucial for ecosystem functioning and carbon sequestration, and is sensitive to future shifts in rainfall and drought characteristics. Current peatland models differ in the degree in which hydrological feedbacks are included, but how this affects peatmoss drought projections is unknown. The aim of this paper was to systematically test whether the level of hydrological detail in models could bias projections of water content and drought stress for peatmoss in northern peatlands using downscaled projections for rainfall and potential evapotranspiration in the current (1991-2020) and future climate (2061-2090). We considered four model variants that either include or exclude moss (rain)water storage and peat volume change, as these are two central processes in the hydrological self-regulation of peatmoss carpets. Model performance was validated using field data of a peatland in northern Sweden. Including moss water storage as well as peat volume change resulted in a significant improvement of model performance, despite the extra parameters added. The best performance was achieved if both processes were included. Including moss water storage and peat volume change consistently reduced projected peatmoss drought frequency with >50%, relative to the model excluding both processes. Projected peatmoss drought frequency in the growing season was 17% smaller under future climate than current climate, but was unaffected by including the hydrological self-regulating processes. Our results suggest that ignoring these two fine-scale processes important in hydrological self-regulation of northern peatlands will have large consequences for projected climate change impact on

  20. Modeling an elastic beam with piezoelectric patches by including magnetic effects

    CERN Document Server

    Ozer, A O

    2014-01-01

    Models for piezoelectric beams using Euler-Bernoulli small displacement theory predict the dynamics of slender beams at the low frequency accurately but are insufficient for beams vibrating at high frequencies or beams with low length-to-width aspect ratios. A more thorough model that includes the effects of rotational inertia and shear strain, Mindlin-Timoshenko small displacement theory, is needed to predict the dynamics more accurately for these cases. Moreover, existing models ignore the magnetic effects since the magnetic effects are relatively small. However, it was shown recently \\cite{O-M1} that these effects can substantially change the controllability and stabilizability properties of even a single piezoelectric beam. In this paper, we use a variational approach to derive models that include magnetic effects for an elastic beam with two piezoelectric patches actuated by different voltage sources. Both Euler-Bernoulli and Mindlin-Timoshenko small displacement theories are considered. Due to the magne...

  1. Stability analysis of the extended ADI-FDTD technique including lumped models

    Institute of Scientific and Technical Information of China (English)

    CHEN ZhiHui; CHU QingXin

    2008-01-01

    The numerical stability of the extended alternating-direction-implicit-finite-difference-time-domain (ADI-FDTD) method including lumped models is analyzed.Three common lumped models are investigated:resistor,capacitor,and inductor,and three different formulations for each model are analyzed:the explicit,semi-implicit and implicit schemes.Analysis results show that the extended ADI-FDTD algorithm is not unconditionally stable in the explicit scheme case,and the stability criterion depends on the value of lumped models,but in the semi-implicit and implicit cases,the algorithm is stable.Finally,two simple microstrip circuits including lumped elements are simulated to demonstrate validity of the theoretical results.

  2. The Dynamic Modeling of Multiple Pairs of Spur Gears in Mesh, Including Friction and Geometrical Errors

    Directory of Open Access Journals (Sweden)

    Shengxiang Jia

    2003-01-01

    Full Text Available This article presents a dynamic model of three shafts and two pair of gears in mesh, with 26 degrees of freedom, including the effects of variable tooth stiffness, pitch and profile errors, friction, and a localized tooth crack on one of the gears. The article also details howgeometrical errors in teeth can be included in a model. The model incorporates the effects of variations in torsional mesh stiffness in gear teeth by using a common formula to describe stiffness that occurs as the gears mesh together. The comparison between the presence and absence of geometrical errors in teeth was made by using Matlab and Simulink models, which were developed from the equations of motion. The effects of pitch and profile errors on the resultant input pinion angular velocity coherent-signal of the input pinion's average are discussed by investigating some of the common diagnostic functions and changes to the frequency spectra results.

  3. SAMI2-PE: A model of the ionosphere including multistream interhemispheric photoelectron transport

    Science.gov (United States)

    Varney, R. H.; Swartz, W. E.; Hysell, D. L.; Huba, J. D.

    2012-06-01

    In order to improve model comparisons with recently improved incoherent scatter radar measurements at the Jicamarca Radio Observatory we have added photoelectron transport and energy redistribution to the two dimensional SAMI2 ionospheric model. The photoelectron model uses multiple pitch angle bins, includes effects associated with curved magnetic field lines, and uses an energy degradation procedure which conserves energy on coarse, non-uniformly spaced energy grids. The photoelectron model generates secondary electron production rates and thermal electron heating rates which are then passed to the fluid equations in SAMI2. We then compare electron and ion temperatures and electron densities of this modified SAMI2 model with measurements of these parameters over a range of altitudes from 90 km to 1650 km (L = 1.26) over a 24 hour period. The new electron heating model is a significant improvement over the semi-empirical model used in SAMI2. The electron temperatures above the F-peak from the modified model qualitatively reproduce the shape of the measurements as functions of time and altitude and quantitatively agree with the measurements to within ˜30% or better during the entire day, including during the rapid temperature increase at dawn.

  4. Modeling the cardiovascular system using a nonlinear additive autoregressive model with exogenous input

    Science.gov (United States)

    Riedl, M.; Suhrbier, A.; Malberg, H.; Penzel, T.; Bretthauer, G.; Kurths, J.; Wessel, N.

    2008-07-01

    The parameters of heart rate variability and blood pressure variability have proved to be useful analytical tools in cardiovascular physics and medicine. Model-based analysis of these variabilities additionally leads to new prognostic information about mechanisms behind regulations in the cardiovascular system. In this paper, we analyze the complex interaction between heart rate, systolic blood pressure, and respiration by nonparametric fitted nonlinear additive autoregressive models with external inputs. Therefore, we consider measurements of healthy persons and patients suffering from obstructive sleep apnea syndrome (OSAS), with and without hypertension. It is shown that the proposed nonlinear models are capable of describing short-term fluctuations in heart rate as well as systolic blood pressure significantly better than similar linear ones, which confirms the assumption of nonlinear controlled heart rate and blood pressure. Furthermore, the comparison of the nonlinear and linear approaches reveals that the heart rate and blood pressure variability in healthy subjects is caused by a higher level of noise as well as nonlinearity than in patients suffering from OSAS. The residue analysis points at a further source of heart rate and blood pressure variability in healthy subjects, in addition to heart rate, systolic blood pressure, and respiration. Comparison of the nonlinear models within and among the different groups of subjects suggests the ability to discriminate the cohorts that could lead to a stratification of hypertension risk in OSAS patients.

  5. General spherical anisotropic Jeans models of stellar kinematics: including proper motions and radial velocities

    CERN Document Server

    Cappellari, Michele

    2015-01-01

    Cappellari (2008) presented a flexible and efficient method to model the stellar kinematics of anisotropic axisymmetric and spherical stellar systems. The spherical formalism could be used to model the line-of-sight velocity second moments allowing for essentially arbitrary radial variation in the anisotropy and general luminous and total density profiles. Here we generalize the spherical formalism by providing the expressions for all three components of the projected second moments, including the two proper motion components. A reference implementation is now included in the public JAM package available at http://purl.org/cappellari/software

  6. Modeling Within-Host Dynamics of Influenza Virus Infection Including Immune Responses

    OpenAIRE

    Pawelek, Kasia A.; Huynh, Giao T; Michelle Quinlivan; Ann Cullinane; Libin Rong; Perelson, Alan S.

    2012-01-01

    Influenza virus infection remains a public health problem worldwide. The mechanisms underlying viral control during an uncomplicated influenza virus infection are not fully understood. Here, we developed a mathematical model including both innate and adaptive immune responses to study the within-host dynamics of equine influenza virus infection in horses. By comparing modeling predictions with both interferon and viral kinetic data, we examined the relative roles of target cell availability, ...

  7. A lumped element transformer model including core losses and winding impedances

    OpenAIRE

    Ribbenfjärd, David

    2007-01-01

    In order to design a power transformer it is important to understand its internal electromagnetic behaviour. That can be obtained by measurements on physical transformers, analytical expressions and computer simulations. One benefit with simulations is that the transformer can be studied before it is built physically and that the consequences of changing dimensions and parameters easily can be tested. In this thesis a time-domain transformer model is presented. The model includes core losses ...

  8. Target echo strength modelling at FOI, including results from the BeTSSi II workshop

    CERN Document Server

    Östberg, Martin

    2016-01-01

    An overview of the target echo strength (TS) modelling capacity at the Swedish Defense Research Agency (FOI) is presented. The modelling methods described range from approximate ones, such as raytracing and Kirchhoff approximation codes, to high accuracy full field codes including boundary integral equation methods and finite elements methods. Illustrations of the applicability of the codes are given for a few simple cases tackled during the BeTTSi II (Benchmark Target Echo Strength Simulation) workshop held in Kiel 2014.

  9. Including leakage in network models: an application to calibrate leak valves in EPANET

    OpenAIRE

    Cobacho Jordán, Ricardo; Arregui de la Cruz, Francisco; Soriano Olivares, Javier; Cabrera Rochera, Enrique

    2015-01-01

    EPANET is one of the most widely used software packages for water network hydraulic modelling, and is especially interesting for educational and research purposes because it is in the public domain. However, EPANET simulations are demand-driven, and the program does not include a specific functionality to model water leakage, which is pressure-driven. Consequently, users are required to deal with this drawback by themselves. As a general solution for this problem, this paper presents a method...

  10. Generalized neurofuzzy network modeling algorithms using Bézier-Bernstein polynomial functions and additive decomposition.

    Science.gov (United States)

    Hong, X; Harris, C J

    2000-01-01

    This paper introduces a new neurofuzzy model construction algorithm for nonlinear dynamic systems based upon basis functions that are Bézier-Bernstein polynomial functions. This paper is generalized in that it copes with n-dimensional inputs by utilising an additive decomposition construction to overcome the curse of dimensionality associated with high n. This new construction algorithm also introduces univariate Bézier-Bernstein polynomial functions for the completeness of the generalized procedure. Like the B-spline expansion based neurofuzzy systems, Bézier-Bernstein polynomial function based neurofuzzy networks hold desirable properties such as nonnegativity of the basis functions, unity of support, and interpretability of basis function as fuzzy membership functions, moreover with the additional advantages of structural parsimony and Delaunay input space partition, essentially overcoming the curse of dimensionality associated with conventional fuzzy and RBF networks. This new modeling network is based on additive decomposition approach together with two separate basis function formation approaches for both univariate and bivariate Bézier-Bernstein polynomial functions used in model construction. The overall network weights are then learnt using conventional least squares methods. Numerical examples are included to demonstrate the effectiveness of this new data based modeling approach.

  11. Key Characteristics of Combined Accident including TLOFW accident for PSA Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bo Gyung; Kang, Hyun Gook [KAIST, Daejeon (Korea, Republic of); Yoon, Ho Joon [Khalifa University of Science, Technology and Research, Abu Dhabi (United Arab Emirates)

    2015-05-15

    The conventional PSA techniques cannot adequately evaluate all events. The conventional PSA models usually focus on single internal events such as DBAs, the external hazards such as fire, seismic. However, the Fukushima accident of Japan in 2011 reveals that very rare event is necessary to be considered in the PSA model to prevent the radioactive release to environment caused by poor treatment based on lack of the information, and to improve the emergency operation procedure. Especially, the results from PSA can be used to decision making for regulators. Moreover, designers can consider the weakness of plant safety based on the quantified results and understand accident sequence based on human actions and system availability. This study is for PSA modeling of combined accidents including total loss of feedwater (TLOFW) accident. The TLOFW accident is a representative accident involving the failure of cooling through secondary side. If the amount of heat transfer is not enough due to the failure of secondary side, the heat will be accumulated to the primary side by continuous core decay heat. Transients with loss of feedwater include total loss of feedwater accident, loss of condenser vacuum accident, and closure of all MSIVs. When residual heat removal by the secondary side is terminated, the safety injection into the RCS with direct primary depressurization would provide alternative heat removal. This operation is called feed and bleed (F and B) operation. Combined accidents including TLOFW accident are very rare event and partially considered in conventional PSA model. Since the necessity of F and B operation is related to plant conditions, the PSA modeling for combined accidents including TLOFW accident is necessary to identify the design and operational vulnerabilities.The PSA is significant to assess the risk of NPPs, and to identify the design and operational vulnerabilities. Even though the combined accident is very rare event, the consequence of combined

  12. Analysis of a generalized model for influenza including differential susceptibility due to immunosuppression

    Science.gov (United States)

    Hincapié, Doracelly; Ospina, Juan

    2014-06-01

    Recently, a mathematical model of pandemic influenza was proposed including typical control strategies such as antivirals, vaccination and school closure; and considering explicitly the effects of immunity acquired from the early outbreaks on the ulterior outbreaks of the disease. In such model the algebraic expression for the basic reproduction number (without control strategies) and the effective reproduction number (with control strategies) were derived and numerically estimated. A drawback of this model of pandemic influenza is that it ignores the effects of the differential susceptibility due to immunosuppression and the effects of the complexity of the actual contact networks between individuals. We have developed a generalized model which includes such effects of heterogeneity. Specifically we consider the influence of the air network connectivity in the spread of pandemic influenza and the influence of the immunosuppresion when the population is divided in two immune classes. We use an algebraic expression, namely the Tutte polynomial, to characterize the complexity of the contact network. Until now, The influence of the air network connectivity in the spread of pandemic influenza has been studied numerically, but not algebraic expressions have been used to summarize the level of network complexity. The generalized model proposed here includes the typical control strategies previously mentioned (antivirals, vaccination and school closure) combined with restrictions on travel. For the generalized model the corresponding reproduction numbers will be algebraically computed and the effect of the contact network will be established in terms of the Tutte polynomial of the network.

  13. The No-Core Gamow Shell Model: Including the continuum in the NCSM

    CERN Document Server

    Barrett, B R; Michel, N; Płoszajczak, M

    2015-01-01

    We are witnessing an era of intense experimental efforts that will provide information about the properties of nuclei far from the line of stability, regarding resonant and scattering states as well as (weakly) bound states. This talk describes our formalism for including these necessary ingredients into the No-Core Shell Model by using the Gamow Shell Model approach. Applications of this new approach, known as the No-Core Gamow Shell Model, both to benchmark cases as well as to unstable nuclei will be given.

  14. The Watts-Strogatz network model developed by including degree distribution: theory and computer simulation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Y W [Surface Physics Laboratory and Department of Physics, Fudan University, Shanghai 200433 (China); Zhang, L F [Surface Physics Laboratory and Department of Physics, Fudan University, Shanghai 200433 (China); Huang, J P [Surface Physics Laboratory and Department of Physics, Fudan University, Shanghai 200433 (China)

    2007-07-20

    By using theoretical analysis and computer simulations, we develop the Watts-Strogatz network model by including degree distribution, in an attempt to improve the comparison between characteristic path lengths and clustering coefficients predicted by the original Watts-Strogatz network model and those of the real networks with the small-world property. Good agreement between the predictions of the theoretical analysis and those of the computer simulations has been shown. It is found that the developed Watts-Strogatz network model can fit the real small-world networks more satisfactorily. Some other interesting results are also reported by adjusting the parameters in a model degree-distribution function. The developed Watts-Strogatz network model is expected to help in the future analysis of various social problems as well as financial markets with the small-world property.

  15. Dynamics Analysis of an HIV Infection Model including Infected Cells in an Eclipse Stage

    Directory of Open Access Journals (Sweden)

    Shengyu Zhou

    2013-01-01

    Full Text Available In this paper, an HIV infection model including an eclipse stage of infected cells is considered. Some quicker cells in this stage become productively infected cells, a portion of these cells are reverted to the uninfected class, and others will be latent down in the body. We consider CTL-response delay in this model and analyze the effect of time delay on stability of equilibrium. It is shown that the uninfected equilibrium and CTL-absent infection equilibrium are globally asymptotically stable for both ODE and DDE model. And we get the global stability of the CTL-present equilibrium for ODE model. For DDE model, we have proved that the CTL-present equilibrium is locally asymptotically stable in a range of delays and also have studied the existence of Hopf bifurcations at the CTL-present equilibrium. Numerical simulations are carried out to support our main results.

  16. Modeling of the dynamics of wind to power conversion including high wind speed behavior

    DEFF Research Database (Denmark)

    Litong-Palima, Marisciel; Bjerge, Martin Huus; Cutululis, Nicolaos Antonio

    2016-01-01

    of power system studies, but the idea of the proposed wind turbine model is to include the main dynamic effects in order to have a better representation of the fluctuations in the output power and of the fast power ramping especially because of high wind speed shutdowns of the wind turbine. The high wind......This paper proposes and validates an efficient, generic and computationally simple dynamic model for the conversion of the wind speed at hub height into the electrical power by a wind turbine. This proposed wind turbine model was developed as a first step to simulate wind power time series...... for power system studies. This paper focuses on describing and validating the single wind turbine model, and is therefore neither describing wind speed modeling nor aggregation of contributions from a whole wind farm or a power system area. The state-of-the-art is to use static power curves for the purpose...

  17. Constraints on gen4eralized Chaplygin gas model including gamma-ray bursts

    Institute of Scientific and Technical Information of China (English)

    Fa-Yin Wang; Zi-Gao Dai; Shi Qi

    2009-01-01

    Generalized Chaplygin gas (whose equation of state is PGCG = -A/PGCGα) was proposed as a candidate for unification of dark energy and dark matter. We inves-tigate constraints on this model with the latest observed data. We test the model with type-Ia supernovae (SNe Ia), cosmic microwave background (CMB) anisotropy, X-ray gas mass fractions in clusters, and gamma-ray bursts (GRBs). We calibrate the GRB lu-minosity relations without assuming any cosmological models using SNe Ia. We show that GRBs can extend the Hubble diagram to higher redshifts (z> 6). The GRB Hubble diagram is well behaved and delineates the shape of the Hubble diagram well. We mea-sure As≡A/PGCG,0α+1=0.68-0.08+0.04 (where PGCG,0 is the energy density today) and α=-0.22-0.13+0.15at the 1σconfidence level using all the datasets. Our results rule out the standard Chaplygin gas model (α = 1) at the 3a confidence level. The ACDM is allowed at the 2or confidence level. We find that acceleration could have started at a redshift of z ~ 0.70. The concordance of the generalized Chaplygin gas model with the age estimate of an old high redshift quasar is found. In addition, we show that GRBs can break the degeneracy between the generalized Chaplygin gas model and the XCDM model.

  18. Accurate and efficient modeling of global seismic wave propagation for an attenuative Earth model including the center

    Science.gov (United States)

    Toyokuni, Genti; Takenaka, Hiroshi

    2012-06-01

    We propose a method for modeling global seismic wave propagation through an attenuative Earth model including the center. This method enables accurate and efficient computations since it is based on the 2.5-D approach, which solves wave equations only on a 2-D cross section of the whole Earth and can correctly model 3-D geometrical spreading. We extend a numerical scheme for the elastic waves in spherical coordinates using the finite-difference method (FDM), to solve the viscoelastodynamic equation. For computation of realistic seismic wave propagation, incorporation of anelastic attenuation is crucial. Since the nature of Earth material is both elastic solid and viscous fluid, we should solve stress-strain relations of viscoelastic material, including attenuative structures. These relations represent the stress as a convolution integral in time, which has had difficulty treating viscoelasticity in time-domain computation such as the FDM. However, we now have a method using so-called memory variables, invented in the 1980s, followed by improvements in Cartesian coordinates. Arbitrary values of the quality factor (Q) can be incorporated into the wave equation via an array of Zener bodies. We also introduce the multi-domain, an FD grid of several layers with different grid spacings, into our FDM scheme. This allows wider lateral grid spacings with depth, so as not to perturb the FD stability criterion around the Earth center. In addition, we propose a technique to avoid the singularity problem of the wave equation in spherical coordinates at the Earth center. We develop a scheme to calculate wavefield variables on this point, based on linear interpolation for the velocity-stress, staggered-grid FDM. This scheme is validated through a comparison of synthetic seismograms with those obtained by the Direct Solution Method for a spherically symmetric Earth model, showing excellent accuracy for our FDM scheme. As a numerical example, we apply the method to simulate seismic

  19. A statistical model including age to predict passenger postures in the rear seats of automobiles.

    Science.gov (United States)

    Park, Jangwoon; Ebert, Sheila M; Reed, Matthew P; Hallman, Jason J

    2016-06-01

    Few statistical models of rear seat passenger posture have been published, and none has taken into account the effects of occupant age. This study developed new statistical models for predicting passenger postures in the rear seats of automobiles. Postures of 89 adults with a wide range of age and body size were measured in a laboratory mock-up in seven seat configurations. Posture-prediction models for female and male passengers were separately developed by stepwise regression using age, body dimensions, seat configurations and two-way interactions as potential predictors. Passenger posture was significantly associated with age and the effects of other two-way interaction variables depended on age. A set of posture-prediction models are presented for women and men, and the prediction results are compared with previously published models. This study is the first study of passenger posture to include a large cohort of older passengers and the first to report a significant effect of age for adults. The presented models can be used to position computational and physical human models for vehicle design and assessment. Practitioner Summary: The significant effects of age, body dimensions and seat configuration on rear seat passenger posture were identified. The models can be used to accurately position computational human models or crash test dummies for older passengers in known rear seat configurations.

  20. Innovative Liner Concepts: Experiments and Impedance Modeling of Liners Including the Effect of Bias Flow

    Science.gov (United States)

    Kelly, Jeff; Betts, Juan Fernando; Fuller, Chris

    2000-01-01

    The study of normal impedance of perforated plate acoustic liners including the effect of bias flow was studied. Two impedance models were developed by modeling the internal flows of perforate orifices as infinite tubes with the inclusion of end corrections to handle finite length effects. These models assumed incompressible and compressible flows, respectively, between the far field and the perforate orifice. The incompressible model was used to predict impedance results for perforated plates with percent open areas ranging from 5% to 15%. The predicted resistance results showed better agreement with experiments for the higher percent open area samples. The agreement also tended to deteriorate as bias flow was increased. For perforated plates with percent open areas ranging from 1% to 5%, the compressible model was used to predict impedance results. The model predictions were closer to the experimental resistance results for the 2% to 3% open area samples. The predictions tended to deteriorate as bias flow was increased. The reactance results were well predicted by the models for the higher percent open area, but deteriorated as the percent open area was lowered (5%) and bias flow was increased. A fit was done on the incompressible model to the experimental database. The fit was performed using an optimization routine that found the optimal set of multiplication coefficients to the non-dimensional groups that minimized the least squares slope error between predictions and experiments. The result of the fit indicated that terms not associated with bias flow required a greater degree of correction than the terms associated with the bias flow. This model improved agreement with experiments by nearly 15% for the low percent open area (5%) samples when compared to the unfitted model. The fitted model and the unfitted model performed equally well for the higher percent open area (10% and 15%).

  1. Introducing COZIGAM: An R Package for Unconstrained and Constrained Zero-Inflated Generalized Additive Model Analysis

    Directory of Open Access Journals (Sweden)

    Hai Liu

    2010-10-01

    Full Text Available Zero-inflation problem is very common in ecological studies as well as other areas. Nonparametric regression with zero-inflated data may be studied via the zero-inflated generalized additive model (ZIGAM, which assumes that the zero-inflated responses come from a probabilistic mixture of zero and a regular component whose distribution belongs to the 1-parameter exponential family. With the further assumption that the probability of non-zero-inflation is some monotonic function of the mean of the regular component, we propose the constrained zero-inflated generalized additive model (COZIGAM for analyzingzero-inflated data. When the hypothesized constraint obtains, the new approach provides a unified framework for modeling zero-inflated data, which is more parsimonious and efficient than the unconstrained ZIGAM. We have developed an R package COZIGAM which contains functions that implement an iterative algorithm for fitting ZIGAMs and COZIGAMs to zero-inflated data basedon the penalized likelihood approach. Other functions included in the package are useful for model prediction and model selection. We demonstrate the use of the COZIGAM package via some simulation studies and a real application.

  2. Fusion rules for the logarithmic $N=1$ superconformal minimal models II: including the Ramond sector

    CERN Document Server

    Canagasabey, Michael

    2015-01-01

    The Virasoro logarithmic minimal models were intensively studied by several groups over the last ten years with much attention paid to the fusion rules and the structures of the indecomposable representations that fusion generates. The analogous study of the fusion rules of the $N=1$ superconformal logarithmic minimal models was initiated in arXiv:1504.03155 as a continuum counterpart to the lattice explorations of arXiv:1312.6763. These works restricted fusion considerations to Neveu-Schwarz representations. Here, this is extended to include the Ramond sector. Technical advances that make this possible include a fermionic Verlinde formula applicable to logarithmic conformal field theories and a twisted version of the fusion algorithm of Nahm and Gaberdiel-Kausch. The results include the first construction and detailed analysis of logarithmic structures in the Ramond sector.

  3. Hybrid Model Representation of a TLP Including Flexible Topsides in Non-Linear Regular Waves

    Directory of Open Access Journals (Sweden)

    Christof Wehmeyer

    2014-08-01

    Full Text Available The rising demand for renewable energy solutions is forcing the established industries to expand and continue evolving. For the wind energy sector, the vast resources in deep sea locations have encouraged research towards the installation of turbines in deeper waters. One of the most promising technologies able to solve this challenge is the floating wind turbine foundation. For the ultimate limit state, where higher order wave loads have a significant influence, a design tool that couples non-linear excitations with structural dynamics is required. To properly describe the behavior of such a structure, a numerical model is proposed and validated by physical test results. The model is applied to a case study of a tension leg platform with a flexible topside mimicking the tower and a lumped mass mimicking the rotor-nacelle assembly. The model is additionally compared to current commercial software, where the need for the coupled higher order dynamics proposed in this paper becomes evident.

  4. MEMLS3&a: Microwave Emission Model of Layered Snowpacks adapted to include backscattering

    Directory of Open Access Journals (Sweden)

    M. Proksch

    2015-08-01

    Full Text Available The Microwave Emission Model of Layered Snowpacks (MEMLS was originally developed for microwave emissions of snowpacks in the frequency range 5–100 GHz. It is based on six-flux theory to describe radiative transfer in snow including absorption, multiple volume scattering, radiation trapping due to internal reflection and a combination of coherent and incoherent superposition of reflections between horizontal layer interfaces. Here we introduce MEMLS3&a, an extension of MEMLS, which includes a backscatter model for active microwave remote sensing of snow. The reflectivity is decomposed into diffuse and specular components. Slight undulations of the snow surface are taken into account. The treatment of like- and cross-polarization is accomplished by an empirical splitting parameter q. MEMLS3&a (as well as MEMLS is set up in a way that snow input parameters can be derived by objective measurement methods which avoid fitting procedures of the scattering efficiency of snow, required by several other models. For the validation of the model we have used a combination of active and passive measurements from the NoSREx (Nordic Snow Radar Experiment campaign in Sodankylä, Finland. We find a reasonable agreement between the measurements and simulations, subject to uncertainties in hitherto unmeasured input parameters of the backscatter model. The model is written in Matlab and the code is publicly available for download through the following website: http://www.iapmw.unibe.ch/research/projects/snowtools/memls.html.

  5. MEMLS3&a: Microwave Emission Model of Layered Snowpacks adapted to include backscattering

    Directory of Open Access Journals (Sweden)

    M. Proksch

    2015-03-01

    Full Text Available The Microwave Emission Model of Layered Snowpacks (MEMLS was originally developed for microwave emissions of snowpacks in the frequency range 5–100 GHz. It is based on six-flux theory to describe radiative transfer in snow including absorption, multiple volume scattering, radiation trapping due to internal reflection and a combination of coherent and incoherent superposition of reflections between horizontal layer interfaces. Here we introduce MEMLS3&a, an extension of MEMLS, which includes a backscatter model for active microwave remote sensing of snow. The reflectivity is decomposed into diffuse and specular components. Slight undulations of the snow surface are taken into account. The treatment of like and cross polarization is accomplished by an empirical splitting parameter q. MEMLS3&a (as well as MEMLS is set up in a way that snow input parameters can be derived by objective measurement methods which avoids fitting procedures of the scattering efficiency of snow, required by several other models. For the validation of the model we have used a combination of active and passive measurements from the NoSREx campaign in Sodankylä, Finland. We find a reasonable agreement between the measurements and simulations, subject to uncertainties in hitherto unmeasured input parameters of the backscatter model. The model is written in MATLAB and the code is publicly available for download through the following website: http://www.iapmw.unibe.ch/research/projects/snowtools/memls.html.

  6. MEMLS3&a: Microwave Emission Model of Layered Snowpacks adapted to include backscattering

    Science.gov (United States)

    Proksch, M.; Mätzler, C.; Wiesmann, A.; Lemmetyinen, J.; Schwank, M.; Löwe, H.; Schneebeli, M.

    2015-08-01

    The Microwave Emission Model of Layered Snowpacks (MEMLS) was originally developed for microwave emissions of snowpacks in the frequency range 5-100 GHz. It is based on six-flux theory to describe radiative transfer in snow including absorption, multiple volume scattering, radiation trapping due to internal reflection and a combination of coherent and incoherent superposition of reflections between horizontal layer interfaces. Here we introduce MEMLS3&a, an extension of MEMLS, which includes a backscatter model for active microwave remote sensing of snow. The reflectivity is decomposed into diffuse and specular components. Slight undulations of the snow surface are taken into account. The treatment of like- and cross-polarization is accomplished by an empirical splitting parameter q. MEMLS3&a (as well as MEMLS) is set up in a way that snow input parameters can be derived by objective measurement methods which avoid fitting procedures of the scattering efficiency of snow, required by several other models. For the validation of the model we have used a combination of active and passive measurements from the NoSREx (Nordic Snow Radar Experiment) campaign in Sodankylä, Finland. We find a reasonable agreement between the measurements and simulations, subject to uncertainties in hitherto unmeasured input parameters of the backscatter model. The model is written in Matlab and the code is publicly available for download through the following website: http://www.iapmw.unibe.ch/research/projects/snowtools/memls.html.

  7. Diagnosing Lee Wave Rotor Onset Using a Linear Model Including a Boundary Layer

    Directory of Open Access Journals (Sweden)

    Miguel A. C. Teixeira

    2017-01-01

    Full Text Available A linear model is used to diagnose the onset of rotors in flow over 2D hills, for atmospheres that are neutrally stratified near the surface and stably stratified aloft, with a sharp temperature inversion in between, where trapped lee waves may propagate. This is achieved by coupling an inviscid two-layer mountain-wave model and a bulk boundary-layer model. The full model shows some ability to diagnose flow stagnation associated with rotors as a function of key input parameters, such as the Froude number and the height of the inversion, in numerical simulations and laboratory experiments carried out by previous authors. While calculations including only the effects of mean flow attenuation and velocity perturbation amplification within the surface layer represent flow stagnation fairly well in the more non-hydrostatic cases, only the full model, taking into account the feedback of the surface layer on the inviscid flow, satisfactorily predicts flow stagnation in the most hydrostatic case, although the corresponding condition is unable to discriminate between rotors and hydraulic jumps. Versions of the model not including this feedback severely underestimate the amplitude of trapped lee waves in that case, where the Fourier transform of the hill has zeros, showing that those waves are not forced directly by the orography.

  8. Steady-state analysis of activated sludge processes with a settler model including sludge compression.

    Science.gov (United States)

    Diehl, S; Zambrano, J; Carlsson, B

    2016-01-01

    A reduced model of a completely stirred-tank bioreactor coupled to a settling tank with recycle is analyzed in its steady states. In the reactor, the concentrations of one dominant particulate biomass and one soluble substrate component are modelled. While the biomass decay rate is assumed to be constant, growth kinetics can depend on both substrate and biomass concentrations, and optionally model substrate inhibition. Compressive and hindered settling phenomena are included using the Bürger-Diehl settler model, which consists of a partial differential equation. Steady-state solutions of this partial differential equation are obtained from an ordinary differential equation, making steady-state analysis of the entire plant difficult. A key result showing that the ordinary differential equation can be replaced with an approximate algebraic equation simplifies model analysis. This algebraic equation takes the location of the sludge-blanket during normal operation into account, allowing for the limiting flux capacity caused by compressive settling to easily be included in the steady-state mass balance equations for the entire plant system. This novel approach grants the possibility of more realistic solutions than other previously published reduced models, comprised of yet simpler settler assumptions. The steady-state concentrations, solids residence time, and the wastage flow ratio are functions of the recycle ratio. Solutions are shown for various growth kinetics; with different values of biomass decay rate, influent volumetric flow, and substrate concentration.

  9. A Coupled MHD and Thermal Model Including Electrostatic Sheath for Magnetoplasmadynamic Thruster Simulation

    Science.gov (United States)

    Kawasaki, Akira; Kubota, Kenichi; Funaki, Ikkoh; Okuno, Yoshihiro

    2016-09-01

    Steady-state and self-field magnetoplasmadynamic (MPD) thruster, which utilizes high-intensity direct-current (DC) discharge, is one of the prospective candidates of future high-power electric propulsion devices. In order to accurately assess the thrust performance and the electrode temperature, input electric power and wall heat flux must correctly be evaluated where electrostatic sheaths formed in close proximity of the electrodes affect these quantities. Conventional model simulates only plasma flows occurring in MPD thrusters with the absence of electrostatic sheath consideration. Therefore, this study extends the conventional model to a coupled magnetohydrodynamic (MHD) and thermal model by incorporating the phenomena relevant to the electrostatic sheaths. The sheaths are implemented as boundary condition of the MHD model on the walls. This model simulated the operation of the 100-kW-class thruster at discharge current ranging from 6 to 10 kA with argon propellant. The extended model reproduced the discharge voltages and wall heat load which are consistent with past experimental results. In addition, the simulation results indicated that cathode sheath voltages account for approximately 5-7 V subject to approximately 20 V of discharge voltages applied between the electrodes. This work was supported by JSPS KAKENHI Grant Numbers 26289328 and 15J10821.

  10. Validation analysis of probabilistic models of dietary exposure to food additives.

    Science.gov (United States)

    Gilsenan, M B; Thompson, R L; Lambe, J; Gibney, M J

    2003-10-01

    The validity of a range of simple conceptual models designed specifically for the estimation of food additive intakes using probabilistic analysis was assessed. Modelled intake estimates that fell below traditional conservative point estimates of intake and above 'true' additive intakes (calculated from a reference database at brand level) were considered to be in a valid region. Models were developed for 10 food additives by combining food intake data, the probability of an additive being present in a food group and additive concentration data. Food intake and additive concentration data were entered as raw data or as a lognormal distribution, and the probability of an additive being present was entered based on the per cent brands or the per cent eating occasions within a food group that contained an additive. Since the three model components assumed two possible modes of input, the validity of eight (2(3)) model combinations was assessed. All model inputs were derived from the reference database. An iterative approach was employed in which the validity of individual model components was assessed first, followed by validation of full conceptual models. While the distribution of intake estimates from models fell below conservative intakes, which assume that the additive is present at maximum permitted levels (MPLs) in all foods in which it is permitted, intake estimates were not consistently above 'true' intakes. These analyses indicate the need for more complex models for the estimation of food additive intakes using probabilistic analysis. Such models should incorporate information on market share and/or brand loyalty.

  11. Latest cosmological constraints on Cardassian expansion models including the updated gamma-ray bursts

    Institute of Scientific and Technical Information of China (English)

    Nan Liang; Pu-Xun Wua; Zong-Hong Zhu

    2011-01-01

    We constrain the Cardassian expansion models from the latest observations,including the updated Gamma-ray bursts (GRBs),which are calibrated using a cosmology independent method from the Union2 compilation of type Ia supernovae (SNe Ia).By combining the GRB data with the joint observations from the Union2SNe Ia set,along with the results from the Cosmic Microwave Background radiation observation from the seven-year Wilkinson Microwave Anisotropy Probe and the baryonic acoustic oscillation observation galaxy sample from the spectroscopic Sloan Digital Sky Survey Data Release,we find significant constraints on the model parameters of the original Cardassian model ΩM0=n 282+0.015-0.014,n=0.03+0.05-0.05;and n = -0.16+0.25-3.26,β=-0.76+0.34-0.58 of the modified polytropic Cardassian model,which are consistent with the ACDM model in a l-σ confidence region.From the reconstruction of the deceleration parameter q(z) in Cardassian models,we obtain the transition redshift ZT = 0.73 ± 0.04 for the original Cardassian model and ZT = 0.68 ± 0.04 for the modified polytropic Cardassian model.

  12. A unified analytical drain current model for Double-Gate Junctionless Field-Effect Transistors including short channel effects

    Science.gov (United States)

    Raksharam; Dutta, Aloke K.

    2017-04-01

    In this paper, a unified analytical model for the drain current of a symmetric Double-Gate Junctionless Field-Effect Transistor (DG-JLFET) is presented. The operation of the device has been classified into four modes: subthreshold, semi-depleted, accumulation, and hybrid; with the main focus of this work being on the accumulation mode, which has not been dealt with in detail so far in the literature. A physics-based model, using a simplified one-dimensional approach, has been developed for this mode, and it has been successfully integrated with the model for the hybrid mode. It also includes the effect of carrier mobility degradation due to the transverse electric field, which was hitherto missing in the earlier models reported in the literature. The piece-wise models have been unified using suitable interpolation functions. In addition, the model includes two most important short-channel effects pertaining to DG-JLFETs, namely the Drain Induced Barrier Lowering (DIBL) and the Subthreshold Swing (SS) degradation. The model is completely analytical, and is thus computationally highly efficient. The results of our model have shown an excellent match with those obtained from TCAD simulations for both long- and short-channel devices, as well as with the experimental data reported in the literature.

  13. A Lumped Thermal Model Including Thermal Coupling and Thermal Boundary Conditions for High Power IGBT Modules

    DEFF Research Database (Denmark)

    Bahman, Amir Sajjad; Ma, Ke; Blaabjerg, Frede

    2017-01-01

    Detailed thermal dynamics of high power IGBT modules are important information for the reliability analysis and thermal design of power electronic systems. However, the existing thermal models have their limits to correctly predict these complicated thermal behavior in the IGBTs: The typically used...... thermal distribution under long-term studies. Meanwhile the boundary conditions for the thermal analysis are modeled and included, which can be adapted to different real field applications of power electronic converters. Finally, the accuracy of the proposed thermal model is verified by FEM simulations...... thermal model based on one-dimensional RC lumps have limits to provide temperature distributions inside the device, moreover some variable factors in the real-field applications like the cooling and heating conditions of the converter cannot be adapted. On the other hand, the more advanced three...

  14. A Lumped Thermal Model Including Thermal Coupling and Thermal Boundary Conditions for High Power IGBT Modules

    DEFF Research Database (Denmark)

    Bahman, Amir Sajjad; Ma, Ke; Blaabjerg, Frede

    2017-01-01

    Detailed thermal dynamics of high power IGBT modules are important information for the reliability analysis and thermal design of power electronic systems. However, the existing thermal models have their limits to correctly predict these complicated thermal behavior in the IGBTs: The typically used...... thermal distribution under long-term studies. Meanwhile the boundary conditions for the thermal analysis are modeled and included, which can be adapted to different real-field applications of power electronic converters. Finally, the accuracy of the proposed thermal model is verified by FEM simulations...... thermal model based on one-dimensional RC lumps have limits to provide temperature distributions inside the device, moreover some variable factors in the real-field applications like the cooling and heating conditions of the converter cannot be adapted. On the other hand, the more advanced three...

  15. Measurement of [Formula: see text] production with additional jet activity, including [Formula: see text] quark jets, in the dilepton decay channel using pp collisions at [Formula: see text].

    Science.gov (United States)

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Eminizer, N; Fehling, D; Feng, L; Gritsan, A V; Maksimovic, P; Martin, C; Osherson, M; Roskes, J; Sady, A; Sarica, U; Swartz, M; Xiao, M; Xin, Y; You, C; Xiao, M; Baringer, P; Bean, A; Benelli, G; Bruner, C; Kenny, R P; Majumder, D; Majumder, D; Malek, M; Murray, M; Sanders, S; Stringer, R; Wang, Q; Ivanov, A; Kaadze, K; Khalil, S; Makouski, M; Maravin, Y; Mohammadi, A; Saini, L K; Skhirtladze, N; Toda, S; Lange, D; Rebassoo, F; Wright, D; Anelli, C; Baden, A; Baron, O; Belloni, A; Calvert, B; Eno, S C; Ferraioli, C; Gomez, J A; Hadley, N J; Jabeen, S; Jabeen, S; Kellogg, R G; Kolberg, T; Kunkle, J; Lu, Y; Mignerey, A C; Shin, Y H; Skuja, A; Tonjes, M B; Tonwar, S C; Apyan, A; Barbieri, R; Baty, A; Bierwagen, K; Brandt, S; Bierwagen, K; Busza, W; Cali, I A; Demiragli, Z; Di Matteo, L; Gomez Ceballos, G; Goncharov, M; Gulhan, D; Iiyama, Y; Innocenti, G M; Klute, M; Kovalskyi, D; Lai, Y S; Lee, Y-J; Levin, A; Luckey, P D; Marini, A C; Mcginn, C; Mironov, C; Narayanan, S; Niu, X; Paus, C; Ralph, D; Roland, C; Roland, G; Salfeld-Nebgen, J; Stephans, G S F; Sumorok, K; Varma, M; Velicanu, D; Veverka, J; Wang, J; Wang, T W; Wyslouch, B; Yang, M; Zhukova, V; Dahmes, B; Evans, A; Finkel, A; Gude, A; Hansen, P; Kalafut, S; Kao, S C; Klapoetke, K; Kubota, Y; Lesko, Z; Mans, J; Nourbakhsh, S; Ruckstuhl, N; Rusack, R; Tambe, N; Turkewitz, J; Acosta, J G; Oliveros, S; Avdeeva, E; Bloom, K; Bose, S; Claes, D R; Dominguez, A; Fangmeier, C; Gonzalez Suarez, R; Kamalieddin, R; Keller, J; Knowlton, D; Kravchenko, I; Meier, F; Monroy, J; Ratnikov, F; Siado, J E; Snow, G R; Alyari, M; Dolen, J; George, J; Godshalk, A; Harrington, C; Iashvili, I; Kaisen, J; Kharchilava, A; Kumar, A; Rappoccio, S; Roozbahani, B; Alverson, G; Barberis, E; Baumgartel, D; Chasco, M; Hortiangtham, A; Massironi, A; Morse, D M; Nash, D; Orimoto, T; Teixeira De Lima, R; Trocino, D; Wang, R-J; Wood, D; Zhang, J; Hahn, K A; Kubik, A; Mucia, N; Odell, N; Pollack, B; Pozdnyakov, A; Schmitt, M; Stoynev, S; Sung, K; Trovato, M; Velasco, M; Brinkerhoff, A; Dev, N; Hildreth, M; Jessop, C; Karmgard, D J; Kellams, N; Lannon, K; Lynch, S; Marinelli, N; Meng, F; Mueller, C; Musienko, Y; Pearson, T; Planer, M; Reinsvold, A; Ruchti, R; Smith, G; Taroni, S; Valls, N; Wayne, M; Wolf, M; Woodard, A; Antonelli, L; Brinson, J; Bylsma, B; Durkin, L S; Flowers, S; Hart, A; Hill, C; Hughes, R; Ji, W; Kotov, K; Ling, T Y; Liu, B; Luo, W; Puigh, D; Rodenburg, M; Winer, B L; Wulsin, H W; Driga, O; Elmer, P; Hardenbrook, J; Hebda, P; Koay, S A; Lujan, P; Marlow, D; Medvedeva, T; Mooney, M; Olsen, J; Palmer, C; Piroué, P; Saka, H; Stickland, D; Tully, C; Zuranski, A; Malik, S; Barnes, V E; Benedetti, D; Bortoletto, D; Gutay, L; Jha, M K; Jones, M; Jung, K; Miller, D H; Neumeister, N; Primavera, F; Radburn-Smith, B C; Shi, X; Shipsey, I; Silvers, D; Sun, J; Svyatkovskiy, A; Wang, F; Xie, W; Xu, L; Parashar, N; Stupak, J; Adair, A; Akgun, B; Chen, Z; Ecklund, K M; Geurts, F J M; Guilbaud, M; Li, W; Michlin, B; Northup, M; Padley, B P; Redjimi, R; Roberts, J; Rorie, J; Tu, Z; Zabel, J; Betchart, B; Bodek, A; de Barbaro, P; Demina, R; Eshaq, Y; Ferbel, T; Galanti, M; Galanti, M; Garcia-Bellido, A; Han, J; Harel, A; Hindrichs, O; Hindrichs, O; Khukhunaishvili, A; Petrillo, G; Tan, P; Verzetti, M; Arora, S; Barker, A; Chou, J P; Contreras-Campana, C; Contreras-Campana, E; Duggan, D; Ferencek, D; Gershtein, Y; Gray, R; Halkiadakis, E; Hidas, D; Hughes, E; Kaplan, S; Kunnawalkam Elayavalli, R; Lath, A; Nash, K; Panwalkar, S; Park, M; Salur, S; Schnetzer, S; Sheffield, D; Somalwar, S; Stone, R; Thomas, S; Thomassen, P; Walker, M; Foerster, M; Riley, G; Rose, K; Spanier, S; York, A; Bouhali, O; Castaneda Hernandez, A; Dalchenko, M; De Mattia, M; Delgado, A; Dildick, S; Dildick, S; Eusebi, R; Gilmore, J; Kamon, T; Krutelyov, V; Krutelyov, V; Mueller, R; Osipenkov, I; Pakhotin, Y; Patel, R; Patel, R; Perloff, A; Rose, A; Safonov, A; Tatarinov, A; Ulmer, K A; Akchurin, N; Cowden, C; Damgov, J; Dragoiu, C; Dudero, P R; Faulkner, J; Kunori, S; Lamichhane, K; Lee, S W; Libeiro, T; Undleeb, S; Volobouev, I; Appelt, E; Delannoy, A G; Greene, S; Gurrola, A; Janjam, R; Johns, W; Maguire, C; Mao, Y; Melo, A; Ni, H; Sheldon, P; Snook, B; Tuo, S; Velkovska, J; Xu, Q; Arenton, M W; Cox, B; Francis, B; Goodell, J; Hirosky, R; Ledovskoy, A; Li, H; Lin, C; Neu, C; Sinthuprasith, T; Sun, X; Wang, Y; Wolfe, E; Wood, J; Xia, F; Clarke, C; Harr, R; Karchin, P E; Kottachchi Kankanamge Don, C; Lamichhane, P; Sturdy, J; Belknap, D A; Carlsmith, D; Cepeda, M; Dasu, S; Dodd, L; Duric, S; Gomber, B; Grothe, M; Hall-Wilton, R; Herndon, M; Hervé, A; Klabbers, P; Lanaro, A; Levine, A; Long, K; Loveless, R; Mohapatra, A; Ojalvo, I; Perry, T; Pierro, G A; Polese, G; Ruggles, T; Sarangi, T; Savin, A; Sharma, A; Smith, N; Smith, W H; Taylor, D; Woods, N; Collaboration, Authorinst The Cms

    2016-01-01

    Jet multiplicity distributions in top quark pair ([Formula: see text]) events are measured in pp collisions at a centre-of-mass energy of 8 TeV with the CMS detector at the LHC using a data set corresponding to an integrated luminosity of 19.7[Formula: see text]. The measurement is performed in the dilepton decay channels ([Formula: see text], [Formula: see text], and [Formula: see text]). The absolute and normalized differential cross sections for [Formula: see text] production are measured as a function of the jet multiplicity in the event for different jet transverse momentum thresholds and the kinematic properties of the leading additional jets. The differential [Formula: see text] and [Formula: see text] cross sections are presented for the first time as a function of the kinematic properties of the leading additional [Formula: see text] jets. Furthermore, the fraction of events without additional jets above a threshold is measured as a function of the transverse momenta of the leading additional jets and the scalar sum of the transverse momenta of all additional jets. The data are compared and found to be consistent with predictions from several perturbative quantum chromodynamics event generators and a next-to-leading order calculation.

  16. Transmission line model for strained quantum well lasers including carrier transport and carrier heating effects.

    Science.gov (United States)

    Xia, Mingjun; Ghafouri-Shiraz, H

    2016-03-01

    This paper reports a new model for strained quantum well lasers, which are based on the quantum well transmission line modeling method where effects of both carrier transport and carrier heating have been included. We have applied this new model and studied the effect of carrier transport on the output waveform of a strained quantum well laser both in time and frequency domains. It has been found that the carrier transport increases the turn-on, turn-off delay times and damping of the quantum well laser transient response. Also, analysis in the frequency domain indicates that the carrier transport causes the output spectrum of the quantum well laser in steady state to exhibit a redshift which has a narrower bandwidth and lower magnitude. The simulation results of turning-on transients obtained by the proposed model are compared with those obtained by the rate equation laser model. The new model has also been used to study the effects of pump current spikes on the laser output waveforms properties, and it was found that the presence of current spikes causes (i) wavelength blueshift, (ii) larger bandwidth, and (iii) reduces the magnitude and decreases the side-lobe suppression ratio of the laser output spectrum. Analysis in both frequency and time domains confirms that the new proposed model can accurately predict the temporal and spectral behaviors of strained quantum well lasers.

  17. A numerical model including PID control of a multizone crystal growth furnace

    Science.gov (United States)

    Panzarella, Charles H.; Kassemi, Mohammad

    This paper presents a 2D axisymmetric combined conduction and radiation model of a multizone crystal growth furnace. The model is based on a programmable multizone furnace (PMZF) designed and built at NASA Lewis Research Center for growing high quality semiconductor crystals. A novel feature of this model is a control algorithm which automatically adjusts the power in any number of independently controlled heaters to establish the desired crystal temperatures in the furnace model. The control algorithm eliminates the need for numerous trial and error runs previously required to obtain the same results. The finite element code, FIDAP, used to develop the furnace model, was modified to directly incorporate the control algorithm. This algorithm, which presently uses PID control, and the associated heat transfer model are briefly discussed. Together, they have been used to predict the heater power distributions for a variety of furnace configurations and desired temperature profiles. Examples are included to demonstrate the effectiveness of the PID controlled model in establishing isothermal, Bridgman, and other complicated temperature profies in the sample. Finally, an example is given to show how the algorithm can be used to change the desired profile with time according to a prescribed temperature-time evolution.

  18. A continuum model of solvation energies including electrostatic, dispersion, and cavity contributions.

    Science.gov (United States)

    Duignan, Timothy T; Parsons, Drew F; Ninham, Barry W

    2013-08-15

    Physically accurate continuum solvent models that can calculate solvation energies are crucial to explain and predict the behavior of solute particles in water. Here, we present such a model applied to small spherical ions and neutral atoms. It improves upon a basic Born electrostatic model by including a standard cavity energy and adding a dispersion component, consistent with the Born electrostatic energy and using the same cavity size parameter. We show that the well-known, puzzling differences between the solvation energies of ions of the same size is attributable to the neglected dispersion contribution. This depends on dynamic polarizability as well as size. Generally, a large cancellation exists between the cavity and dispersion contributions. This explains the surprising success of the Born model. The model accurately reproduces the solvation energies of the alkali halide ions, as well as the silver(I) and copper(I) ions with an error of 12 kJ mol(-1) (±3%). The solvation energy of the noble gases is also reproduced with an error of 2.6 kJ mol(-1) (±30%). No arbitrary fitting parameters are needed to achieve this. This model significantly improves our understanding of ionic solvation and forms a solid basis for the investigation of other ion-specific effects using a continuum solvent model.

  19. A New Circuit Model for Spin-Torque Oscillator Including Perpendicular Torque of Magnetic Tunnel Junction

    Directory of Open Access Journals (Sweden)

    Hyein Lim

    2013-01-01

    Full Text Available Spin-torque oscillator (STO is a promising new technology for the future RF oscillators, which is based on the spin-transfer torque (STT effect in magnetic multilayered nanostructure. It is expected to provide a larger tunability, smaller size, lower power consumption, and higher level of integration than the semiconductor-based oscillators. In our previous work, a circuit-level model of the giant magnetoresistance (GMR STO was proposed. In this paper, we present a physics-based circuit-level model of the magnetic tunnel junction (MTJ-based STO. MTJ-STO model includes the effect of perpendicular torque that has been ignored in the GMR-STO model. The variations of three major characteristics, generation frequency, mean oscillation power, and generation linewidth of an MTJ-STO with respect to the amount of perpendicular torque, are investigated, and the results are applied to our model. The operation of the model was verified by HSPICE simulation, and the results show an excellent agreement with the experimental data. The results also prove that a full circuit-level simulation with MJT-STO devices can be made with our proposed model.

  20. Does including physiology improve species distribution model predictions of responses to recent climate change?

    Science.gov (United States)

    Buckley, Lauren B; Waaser, Stephanie A; MacLean, Heidi J; Fox, Richard

    2011-12-01

    Thermal constraints on development are often invoked to predict insect distributions. These constraints tend to be characterized in species distribution models (SDMs) by calculating development time based on a constant lower development temperature (LDT). Here, we assessed whether species-specific estimates of LDT based on laboratory experiments can improve the ability of SDMs to predict the distribution shifts of six U.K. butterflies in response to recent climate warming. We find that species-specific and constant (5 degrees C) LDT degree-day models perform similarly at predicting distributions during the period of 1970-1982. However, when the models for the 1970-1982 period are projected to predict distributions in 1995-1999 and 2000-2004, species-specific LDT degree-day models modestly outperform constant LDT degree-day models. Our results suggest that, while including species-specific physiology in correlative models may enhance predictions of species' distribution responses to climate change, more detailed models may be needed to adequately account for interspecific physiological differences.

  1. Modeling of single char combustion, including CO oxidation in its boundary layer

    Energy Technology Data Exchange (ETDEWEB)

    Lee, C.H.; Longwell, J.P.; Sarofim, A.F.

    1994-10-25

    The combustion of a char particle can be divided into a transient phase where its temperature increases as it is heated by oxidation, and heat transfer from the surrounding gas to an approximately constant temperature stage where gas phase reaction is important and which consumes most of the carbon and an extinction stage caused by carbon burnout. In this work, separate models were developed for the transient heating where gas phase reactions were unimportant and for the steady temperature stage where gas phase reactions were treated in detail. The transient char combustion model incorporates intrinsic char surface production of CO and CO{sub 2}, internal pore diffusion and external mass and heat transfer. The model provides useful information for particle ignition, burning temperature profile, combustion time, and carbon consumption rate. A gas phase reaction model incorporating the full set of 28 elementary C/H/O reactions was developed. This model calculated the gas phase CO oxidation reaction in the boundary layer at particle temperatures of 1250 K and 2500 K by using the carbon consumption rate and the burning temperature at the pseudo-steady state calculated from the temperature profile model but the transient heating was not included. This gas phase model can predict the gas species, and the temperature distributions in the boundary layer, the CO{sub 2}/CO ratio, and the location of CO oxidation. A mechanistic heat and mass transfer model was added to the temperature profile model to predict combustion behavior in a fluidized bed. These models were applied to data from the fluidized combustion of Newlands coal char particles. 52 refs., 60 figs.

  2. Including source uncertainty and prior information in the analysis of stable isotope mixing models.

    Science.gov (United States)

    Ward, Eric J; Semmens, Brice X; Schindler, Daniel E

    2010-06-15

    Stable isotope mixing models offer a statistical framework for estimating the contribution of multiple sources (such as prey) to a mixture distribution. Recent advances in these models have estimated the source proportions using Bayesian methods, but have not explicitly accounted for uncertainty in the mean and variance of sources. We demonstrate that treating these quantities as unknown parameters can reduce bias in the estimated source contributions, although model complexity is increased (thereby increasing the variance of estimates). The advantages of this fully Bayesian approach are particularly apparent when the source geometry is poor or sample sizes are small. A second benefit to treating source quantities as parameters is that prior source information can be included. We present findings from 9 lake food-webs, where the consumer of interest (fish) has a diet composed of 5 sources: aquatic insects, snails, zooplankton, amphipods, and terrestrial insects. We compared the traditional Bayesian stable isotope mixing model with fixed source parameters to our fully Bayesian model-with and without an informative prior. The informative prior has much less impact than the choice of model-the traditional mixing model with fixed source parameters estimates the diet to be dominated by aquatic insects, while the fully Bayesian model estimates the diet to be more balanced but with greater importance of zooplankton. The findings from this example demonstrate that there can be stark differences in inference between the two model approaches, particularly when the source geometry of the mixing model is poor. These analyses also emphasize the importance of investing substantial effort toward characterizing the variation in the isotopic characteristics of source pools to appropriately quantify uncertainties in their contributions to consumers in food webs.

  3. Kinetic modelling of anaerobic hydrolysis of solid wastes, including disintegration processes

    Energy Technology Data Exchange (ETDEWEB)

    García-Gen, Santiago [Department of Chemical Engineering, Institute of Technology, University of Santiago de Compostela, 15782 Santiago de Compostela (Spain); Sousbie, Philippe; Rangaraj, Ganesh [INRA, UR50, Laboratoire de Biotechnologie de l’Environnement, Avenue des Etangs, Narbonne F-11100 (France); Lema, Juan M. [Department of Chemical Engineering, Institute of Technology, University of Santiago de Compostela, 15782 Santiago de Compostela (Spain); Rodríguez, Jorge, E-mail: jrodriguez@masdar.ac.ae [Department of Chemical Engineering, Institute of Technology, University of Santiago de Compostela, 15782 Santiago de Compostela (Spain); Institute Centre for Water and Environment (iWater), Masdar Institute of Science and Technology, PO Box 54224 Abu Dhabi (United Arab Emirates); Steyer, Jean-Philippe; Torrijos, Michel [INRA, UR50, Laboratoire de Biotechnologie de l’Environnement, Avenue des Etangs, Narbonne F-11100 (France)

    2015-01-15

    Highlights: • Fractionation of solid wastes into readily and slowly biodegradable fractions. • Kinetic coefficients estimation from mono-digestion batch assays. • Validation of kinetic coefficients with a co-digestion continuous experiment. • Simulation of batch and continuous experiments with an ADM1-based model. - Abstract: A methodology to estimate disintegration and hydrolysis kinetic parameters of solid wastes and validate an ADM1-based anaerobic co-digestion model is presented. Kinetic parameters of the model were calibrated from batch reactor experiments treating individually fruit and vegetable wastes (among other residues) following a new protocol for batch tests. In addition, decoupled disintegration kinetics for readily and slowly biodegradable fractions of solid wastes was considered. Calibrated parameters from batch assays of individual substrates were used to validate the model for a semi-continuous co-digestion operation treating simultaneously 5 fruit and vegetable wastes. The semi-continuous experiment was carried out in a lab-scale CSTR reactor for 15 weeks at organic loading rate ranging between 2.0 and 4.7 g VS/L d. The model (built in Matlab/Simulink) fit to a large extent the experimental results in both batch and semi-continuous mode and served as a powerful tool to simulate the digestion or co-digestion of solid wastes.

  4. A void ratio dependent water retention curve model including hydraulic hysteresis

    Directory of Open Access Journals (Sweden)

    Pasha Amin Y.

    2016-01-01

    Full Text Available Past experimental evidence has shown that Water Retention Curve (WRC evolves with mechanical stress and structural changes in soil matrix. Models currently available in the literature for capturing the volume change dependency of WRC are mainly empirical in nature requiring an extensive experimental programme for parameter identification which renders them unsuitable for practical applications. In this paper, an analytical model for the evaluation of the void ratio dependency of WRC in deformable porous media is presented. The approach proposed enables quantification of the dependency of WRC on void ratio solely based on the form of WRC at the reference void ratio and requires no additional parameters. The effect of hydraulic hysteresis on the evolution process is also incorporated in the model, an aspect rarely addressed in the literature. Expressions are presented for the evolution of main and scanning curves due to loading and change in the hydraulic path from scanning to main wetting/drying and vice versa as well as the WRC parameters such as air entry value, air expulsion value, pore size distribution index and slope of the scanning curve. The model is validated using experimental data on compacted and reconstituted soils subjected to various hydro-mechanical paths. Good agreement is obtained between model predictions and experimental data in all the cases considered.

  5. A discrete model for the apparent viscosity of polydisperse suspensions including maximum packing fraction

    CERN Document Server

    Dörr, Aaron; Mehdizadeh, Amirfarhang

    2012-01-01

    Based on the notion of a construction process consisting of the stepwise addition of particles to the pure fluid, a discrete model for the apparent viscosity as well as for the maximum packing fraction of polydisperse suspensions of spherical, non-colloidal particles is derived. The model connects the approaches by Bruggeman and Farris and is valid for large size ratios of consecutive particle classes during the construction process. Furthermore, a new general form of the well-known Krieger equation allowing for the choice of a second-order Taylor coefficient for the volume fraction is proposed and then applied as a monodisperse reference equation in the course of polydisperse modeling. By applying the polydisperse viscosity model to two different particle size distributions (Rosin-Rammler and uniform distribution), the influence of polydispersity on the apparent viscosity is examined. The extension of the model to the case of small size ratios as well as to the inclusion of shear rate effects is left for fut...

  6. Codigestion of solid wastes: a review of its uses and perspectives including modeling.

    Science.gov (United States)

    Mata-Alvarez, Joan; Dosta, Joan; Macé, Sandra; Astals, Sergi

    2011-06-01

    The last two years have witnessed a dramatic increase in the number of papers published on the subject of codigestion, highlighting the relevance of this topic within anaerobic digestion research. Consequently, it seems appropriate to undertake a review of codigestion practices starting from the late 1970s, when the first papers related to this concept were published, and continuing to the present day, demonstrating the exponential growth in the interest shown in this approach in recent years. Following a general analysis of the situation, state-of-the-art codigestion is described, focusing on the two most important areas as regards publication: codigestion involving sewage sludge and the organic fraction of municipal solid waste (including a review of the secondary advantages for wastewater treatment plant related to biological nutrient removal), and codigestion in the agricultural sector, that is, including agricultural - farm wastes, and energy crops. Within these areas, a large number of oversized digesters appear which can be used to codigest other substrates, resulting in economic and environmental advantages. Although the situation may be changing, there is still a need for good examples on an industrial scale, particularly with regard to wastewater treatment plants, in order to extend this beneficial practice. In the last section, a detailed analysis of papers addressing the important aspect of modelisation is included. This analysis includes the first codigestion models to be developed as well as recent applications of the standardised anaerobic digestion model ADM1 to codigestion. (This review includes studies ranging from laboratory to industrial scale.).

  7. Enhanced UWB Radio Channel Model for Short-Range Communication Scenarios Including User Dynamics

    DEFF Research Database (Denmark)

    Kovacs, Istvan Zsolt; Nguyen, Tuan Hung; Eggers, Patrick Claus F.

    2005-01-01

    In this paper we propose a SISO UWB radio channel model for short-range radio link scenarios between a fixed device and a dynamic user hand-held device. The channel model is derived based on novel experimental UWB radio propagation investigations carried out in typical indoor PAN scenarios...... including realistic device and user terminal antenna configurations. The radio channel measurements have been performed in the lower UWB frequency band of 3GHz to 5GHz with a 2x4 MIMO antenna configuration. Several environments, user scenarios and two types of user terminals have been used. The developed...

  8. Fuzzy Control of Yaw and Roll Angles of a Simulated Helicopter Model Includes Articulated Manipulators

    Directory of Open Access Journals (Sweden)

    Hossein Sadegh Lafmejani

    2015-09-01

    Full Text Available Fuzzy logic controller (FLC is a heuristic method by If-Then Rules which resembles human intelligence and it is a good method for designing Non-linear control systems. In this paper, an arbitrary helicopter model includes articulated manipulators has been simulated with Matlab SimMechanics toolbox. Due to the difficulties of modeling this complex system, a fuzzy controller with simple fuzzy rules has been designed for its yaw and roll angles in order to stabilize the helicopter while it is in the presence of disturbances or its manipulators are moving for a task. Results reveal that a simple FLC can appropriately control this system.

  9. Including Finite Surface Span Effects in Empirical Jet-Surface Interaction Noise Models

    Science.gov (United States)

    Brown, Clifford A.

    2016-01-01

    The effect of finite span on the jet-surface interaction noise source and the jet mixing noise shielding and reflection effects is considered using recently acquired experimental data. First, the experimental setup and resulting data are presented with particular attention to the role of surface span on far-field noise. These effects are then included in existing empirical models that have previously assumed that all surfaces are semi-infinite. This extended abstract briefly describes the experimental setup and data leaving the empirical modeling aspects for the final paper.

  10. Analytical model for investigation of interior noise characteristics in aircraft with multiple propellers including synchrophasing

    Science.gov (United States)

    Fuller, C. R.

    1986-01-01

    A simplified analytical model of transmission of noise into the interior of propeller-driven aircraft has been developed. The analysis includes directivity and relative phase effects of the propeller noise sources, and leads to a closed form solution for the coupled motion between the interior and exterior fields via the shell (fuselage) vibrational response. Various situations commonly encountered in considering sound transmission into aircraft fuselages are investigated analytically and the results obtained are compared to measurements in real aircraft. In general the model has proved successful in identifying basic mechanisms behind noise transmission phenomena.

  11. An induction machine model including interbar currents for studying performances during transients and steady state

    Energy Technology Data Exchange (ETDEWEB)

    Razik, H. [Universite Henri Poincare, GREEN, CNRS-UMR 7037, BP 239, F-54506 Vandoeuvre-les-Nancy Cedex (France); Henao, H. [University of Picardie, CREA, 33 rue Saint Leu, F-80039 Amiens Cedex 1 (France); Carlson, R. [GRUCAD/CTC/UFSC, Campus Universitario, C.P. 436, Florianopolis - SC, 88040-900 (Brazil)

    2009-01-15

    This paper presents a mathematical model of a three-phase induction motor taking into consideration the interbar contacts. Several models have been available in the references. However, they consider the rotor of the induction motor as being constituted either a three-phase or a squirrel cage even if it operates under stator and/or rotor faults condition. Nonetheless, the contact between a bar and the iron core for the machine has to be considered, especially when a rotor fault occurs. It is obvious that rotor currents are under the influence of rotor constitution materials. So, the paper aim's concerns a transient model of the induction motors which can consider the rotor broken bars defect. Despite its increasing complexity, it could be able to provide with useful indications for diagnostic purposes. This model is advocated for the simulation of motors behavior under rotor defect which takes into account the interbar currents. The proposed technique is based on the mesh model analysis of the squirrel cage. As low power induction motors are prevalent in industrial plants, we pay a special attention on them. Notwithstanding, additional currents are due to the contact between the non-insulated bar constituting the squirrel cage to the rotor iron core. The monitoring of induction motors is predominantly made through the stator current analysis of the motor when it operates at nominal condition. Moreover, this one is observed in steady state operating system, knowing that the motor is generally fed by a sinusoidal supply. Consequently, simulation results showed in this paper prove the effectiveness of the proposed approach, and the impact of interbar resistance both on the model and the line current spectrum for the diagnostic. An experimental test proves the effectiveness of this model. (author)

  12. Including crystal structure attributes in machine learning models of formation energies via Voronoi tessellations

    Science.gov (United States)

    Ward, Logan; Liu, Ruoqian; Krishna, Amar; Hegde, Vinay I.; Agrawal, Ankit; Choudhary, Alok; Wolverton, Chris

    2017-07-01

    While high-throughput density functional theory (DFT) has become a prevalent tool for materials discovery, it is limited by the relatively large computational cost. In this paper, we explore using DFT data from high-throughput calculations to create faster, surrogate models with machine learning (ML) that can be used to guide new searches. Our method works by using decision tree models to map DFT-calculated formation enthalpies to a set of attributes consisting of two distinct types: (i) composition-dependent attributes of elemental properties (as have been used in previous ML models of DFT formation energies), combined with (ii) attributes derived from the Voronoi tessellation of the compound's crystal structure. The ML models created using this method have half the cross-validation error and similar training and evaluation speeds to models created with the Coulomb matrix and partial radial distribution function methods. For a dataset of 435 000 formation energies taken from the Open Quantum Materials Database (OQMD), our model achieves a mean absolute error of 80 meV/atom in cross validation, which is lower than the approximate error between DFT-computed and experimentally measured formation enthalpies and below 15% of the mean absolute deviation of the training set. We also demonstrate that our method can accurately estimate the formation energy of materials outside of the training set and be used to identify materials with especially large formation enthalpies. We propose that our models can be used to accelerate the discovery of new materials by identifying the most promising materials to study with DFT at little additional computational cost.

  13. An air/sea flux model including the effects of capillary waves

    Science.gov (United States)

    Bourassa, Mark A.

    1993-01-01

    An improved model of the air/sea interface is developed. The improvements consist in including the effect of capillary (surface tension) waves on the tropical surface fluxes and the consideration of the sea state, both of which increase the magnitude of tropical surface fluxes. Changes in surface stress are most significant in the low wind-speed regions, which include the areas where westerly bursts occur. It is shown that the changes, from the regular wind conditions to those of a westerly burst or El-Nino, can double when the effects of capillary waves are considered. This implies a much stronger coupling between the ocean and the atmosphere than is predicted by other boundary layer models.

  14. A complete model of CH+ rotational excitation including radiative and chemical pumping processes

    CERN Document Server

    Godard, Benjamin

    2012-01-01

    Aims. Excitation of far-infrared and submillimetric molecular lines may originate from nonreactive collisions, chemical formation, or far infrared, near-infrared, and optical fluorescences. As a template, we investigate the impact of each of these processes on the excitation of the methylidyne cation CH+ and on the intensities of its rotational transitions recently detected in emission in dense photodissociation regions (PDRs) and in planetary nebulae. Methods. We have developed a nonlocal thermodynamic equilibrium (non-LTE) excitation model that includes the entire energy structure of CH+, i.e. taking into account the pumping of its vibrational and bound and unbound electronic states by near-infrared and optical photons. The model includes the theoretical cross-sections of nonreactive collisions with H, H2, He, and e-, and a Boltzmann distribution is used to describe the probability of populating the excited levels of CH+ during its chemical formation by hydrogenation of C+. To confirm our results we also pe...

  15. Ion-biomolecule collisions studied within the independent atom model including geometric screening corrections

    Science.gov (United States)

    Lüdde, H. J.; Achenbach, A.; Kalkbrenner, T.; Jankowiak, H. C.; Kirchner, T.

    2016-05-01

    A recently introduced model to account for geometric screening corrections in an independent-atom-model description of ion-molecule collisions is applied to proton collisions from amino acids and DNA and RNA nucleobases. The correction coefficients are obtained from using a pixel counting method (PCM) for the exact calculation of the effective cross sectional area that emerges when the molecular cross section is pictured as a structure of (overlapping) atomic cross sections. This structure varies with the relative orientation of the molecule with respect to the projectile beam direction and, accordingly, orientation-independent total cross sections are obtained from averaging the pixel count over many orientations. We present net capture and net ionization cross sections over wide ranges of impact energy and analyze the strength of the screening effect by comparing the PCM results with Bragg additivity rule cross sections and with experimental data where available. Work supported by NSERC, Canada.

  16. A model for thermal oxidation of Si and SiC including material expansion

    Energy Technology Data Exchange (ETDEWEB)

    Christen, T., E-mail: thomas.christen@ch.abb.com; Ioannidis, A. [ABB Corporate Research, Segelhofstrasse 1K, CH-5405 Baden (Switzerland); Winkelmann, C. [ETH Zürich, Seminar for Applied Mathematics, Rämistrasse 101, CH-8092 Zürich (Switzerland)

    2015-02-28

    A model based on drift-diffusion-reaction kinetics for Si and SiC oxidation is discussed, which takes the material expansion into account with an additional convection term. The associated velocity field is determined self-consistently from the local reaction rate. The approach allows a calculation of the densities of volatile species in an nm-resolution at the oxidation front. The model is illustrated with simulation results for the growth and impurity redistribution during Si oxidation and for carbon and silicon emission during SiC oxidation. The approach can be useful for the prediction of Si and/or C interstitial distribution, which is particularly relevant for the quality of metal-oxide-semiconductor electronic devices.

  17. A roller chain drive model including contact with guide-bars

    DEFF Research Database (Denmark)

    Pedersen, Sine Leergaard; Hansen, John Michael; Ambrósio, J. A. C.

    2004-01-01

    and continuous force methods, respectively. In the unilateral constraint methodology the kinematic constraints are introduced in the system anytime a contact between the rollers and the sprockets is detected. The condition for the constraint addition is based on the relative distance between the roller centre...... and the sprocket centre, i.e. a constraint is added when such distance is less than the pitch radius. The unilateral kinematic constraint is removed when its associated constraint reaction force, applied on the roller, is in the direction of the root of the sprocket teeth. In order to improve the numerical...... as continuous force. The model of the roller-chain drive now proposed departs from an earlier model where two contact/impact methods are proposed to describe the contact between the rollers of the chain and the teeth of the sprockets. These different formulations are based on unilateral constraints...

  18. Including Flocculation in a Numerical Sediment Transport Model for a Partially-Mixed Estuary

    Science.gov (United States)

    Tarpley, D.; Harris, C. K.; Friedrichs, C. T.

    2016-12-01

    Particle settling velocity impacts the transport of suspended sediment to the first order but fine-grained material like muds tend to form loosely bound aggregates (flocs) whose settling velocity can vary widely. Properties of flocculated sediment such as settling velocity and particle density are difficult to predict because they change in response to several factors including salinity, suspended sediment concentration, turbulent mixing, and organic content. Knowledge of the mechanisms governing flocculation of cohesive sediment is rapidly expanding; especially in response to recent technical advances. As the understanding of particle dynamics progresses, numerical models describing flocculation and break-up are being developed with varying degrees of complexity. While complex models capture the dynamics of the system, their computational costs may prohibit their incorporation into larger model domains. It is important to determine if the computational costs of intricate floc models are justifiable compared to simpler formulations. For this study, we implement an idealized two-dimensional model designed to represent a longitudinal section of a partially mixed estuary that neglects across-channel variation but exhibits salinity driven estuarine circulation. The idealized domain is designed to mimic the primary features of the York River, VA. Suspended load, erosion and deposition are calculated within the sediment transport routines of the COAWST modeling system. We compare different methods for prescribing settling velocity of fine-grained material. The simplest, standard model neglects flocculation dynamics while the complex treatment is a size-class-based flocculation model (FLOCMOD). Differences in tidal and daily averages of suspended load, bulk settling velocity and bed deposition are compared between the standard and FLOCMOD runs, to examine the relative impact of flocculation on sediment transport patterns. We expect FLOCMOD to have greater variability and

  19. Multistate Statistical Modeling: A Tool to Build a Lung Cancer Microsimulation Model That Includes Parameter Uncertainty and Patient Heterogeneity.

    Science.gov (United States)

    Bongers, Mathilda L; de Ruysscher, Dirk; Oberije, Cary; Lambin, Philippe; Uyl-de Groot, Carin A; Coupé, V M H

    2016-01-01

    With the shift toward individualized treatment, cost-effectiveness models need to incorporate patient and tumor characteristics that may be relevant to treatment planning. In this study, we used multistate statistical modeling to inform a microsimulation model for cost-effectiveness analysis of individualized radiotherapy in lung cancer. The model tracks clinical events over time and takes patient and tumor features into account. Four clinical states were included in the model: alive without progression, local recurrence, metastasis, and death. Individual patients were simulated by repeatedly sampling a patient profile, consisting of patient and tumor characteristics. The transitioning of patients between the health states is governed by personalized time-dependent hazard rates, which were obtained from multistate statistical modeling (MSSM). The model simulations for both the individualized and conventional radiotherapy strategies demonstrated internal and external validity. Therefore, MSSM is a useful technique for obtaining the correlated individualized transition rates that are required for the quantification of a microsimulation model. Moreover, we have used the hazard ratios, their 95% confidence intervals, and their covariance to quantify the parameter uncertainty of the model in a correlated way. The obtained model will be used to evaluate the cost-effectiveness of individualized radiotherapy treatment planning, including the uncertainty of input parameters. We discuss the model-building process and the strengths and weaknesses of using MSSM in a microsimulation model for individualized radiotherapy in lung cancer.

  20. Model for safety reports including descriptive examples; Mall foer saekerhetsrapporter med beskrivande exempel

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    Several safety reports will be produced in the process of planning and constructing the system for disposal of high-level radioactive waste in Sweden. The present report gives a model, with detailed examples, of how these reports should be organized and what steps they should include. In the near future safety reports will deal with the encapsulation plant and the repository. Later reports will treat operation of the handling systems and the repository.

  1. Extending the formal model of a spatial data infrastructure to include volunteered geographical information

    CSIR Research Space (South Africa)

    Cooper, Antony K

    2011-07-01

    Full Text Available an aggregator of VGI, such as Ushahidi, and the provider of the infrastructure for collecting VGI, such as OpenStreetMap. 3) Broker: A stakeholder who brings End Users and Providers together and assists in the negotiation of contracts between them... model of a spatial data infrastructure to include volunteered geographical information Antony K Cooper*, Petr Rapant?, Jan Hjelmager?, Dominique Laurent?, Adam Iwaniak#, Serena Coetzee$, Harold Moellering? and Ulrich D?ren? *Logistics...

  2. A numerical model of the ionosphere, including the E-region above EISCAT

    Directory of Open Access Journals (Sweden)

    P.-Y. Diloy

    Full Text Available It has been previously demonstrated that a two-ion (O+ and H+ 8-moment time-dependent fluid model was able to reproduce correctly the ionospheric structure in the altitude range probed by the EISCAT-VHF radar. In the present study, the model is extended down to the E-region where molecular ion chemistry (NO+ and O+2, essentially prevails over transport; EISCAT-UHF observations confirmed previous theoretical predictions that during events of intense E×B induced convection drifts, molecular ions (mainly NO+ predominate over O+ ions up to altitudes of 300 km. In addition to this extension of the model down to the E-region, the ionization and heating resulting from both solar insolation and particle precipitation is now taken into account in a consistent manner through a complete kinetic transport code. The effects of E×B induced convection drifts on the E- and F-region are presented: the balance between O+ and NO+ ions is drastically affected; the electric field acts to deplete the O+ ion concentration. The [NO+]/[O+] transition altitude varies from 190 km to 320 km as the perpendicular electric field increases from 0 to 100 mV m-1. An interesting additional by-product of the model is that it also predicts the presence of a noticeable fraction of N+ ions in the topside ionosphere in good agreement with Retarding Ion Mass Spectrometer measurements onboard Dynamic Explorer.

  3. QCD Equation of State From a Chiral Hadronic Model Including Quark Degrees of Freedom

    CERN Document Server

    Rau, Philip; Schramm, Stefan; Stöcker, Horst

    2013-01-01

    This work presents an effective model for strongly interacting matter and the QCD equation of state (EoS). The model includes both hadron and quark degrees of freedom and takes into account the transition of chiral symmetry restoration as well as the deconfinement phase transition. At low temperatures $T$ and baryonic densities $\\rho_B$ a hadron resonance gas is described using a SU(3)-flavor sigma-omega model and a quark phase is introduced in analogy to PNJL models for higher $T$ and $\\rho_B$. In this way, the correct asymptotic degrees of freedom are used in a wide range of $T$ and $\\rho_B$. Here, results of this model concerning the chiral and deconfinement phase transitions and thermodynamic model properties are presented. Large hadron resonance multiplicities in the transition region emphasize the importance of heavy-mass resonance states in this region and their impact on the chiral transition behavior. The resulting phase diagram of QCD matter at small chemical potentials is in line with latest lattic...

  4. A High-Rate, Single-Crystal Model including Phase Transformations, Plastic Slip, and Twinning

    Energy Technology Data Exchange (ETDEWEB)

    Addessio, Francis L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Bronkhorst, Curt Allan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Bolme, Cynthia Anne [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Explosive Science and Shock Physics Division; Brown, Donald William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Materials Science and Technology Division; Cerreta, Ellen Kathleen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Materials Science and Technology Division; Lebensohn, Ricardo A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Materials Science and Technology Division; Lookman, Turab [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Luscher, Darby Jon [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Mayeur, Jason Rhea [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Morrow, Benjamin M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Materials Science and Technology Division; Rigg, Paulo A. [Washington State Univ., Pullman, WA (United States). Dept. of Physics. Inst. for Shock Physics

    2016-08-09

    An anisotropic, rate-­dependent, single-­crystal approach for modeling materials under the conditions of high strain rates and pressures is provided. The model includes the effects of large deformations, nonlinear elasticity, phase transformations, and plastic slip and twinning. It is envisioned that the model may be used to examine these coupled effects on the local deformation of materials that are subjected to ballistic impact or explosive loading. The model is formulated using a multiplicative decomposition of the deformation gradient. A plate impact experiment on a multi-­crystal sample of titanium was conducted. The particle velocities at the back surface of three crystal orientations relative to the direction of impact were measured. Molecular dynamics simulations were conducted to investigate the details of the high-­rate deformation and pursue issues related to the phase transformation for titanium. Simulations using the single crystal model were conducted and compared to the high-­rate experimental data for the impact loaded single crystals. The model was found to capture the features of the experiments.

  5. A 3D model of the oculomotor plant including the pulley system

    Energy Technology Data Exchange (ETDEWEB)

    Viegener, A; Armentano, R L [Fundacion Universitaria Dr. Rene G. Favaloro, SolIs 453 (1078) Buenos Aires (Argentina)

    2007-11-15

    Early models of the oculomotor plant only considered the eye globes and the muscles that move them. Recently, connective tissue structures have been found enveloping the extraocular muscles (EOMs) and firmly anchored to the orbital wall. These structures act as pulleys; they determine the functional origin of the EOMs and, in consequence, their effective pulling direction. A three dimensional model of the oculomotor plant, including pulleys, has been developed and simulations in Simulink were performed during saccadic eye movements. Listing's law was implemented based on the supposition that there exists an eye orientation related signal. The inclusion of the pulleys in the model makes this assumption plausible and simplifies the problem of the plant noncommutativity.

  6. A flexible and qualitatively stable model for cell cycle dynamics including DNA damage effects.

    Science.gov (United States)

    Jeffries, Clark D; Johnson, Charles R; Zhou, Tong; Simpson, Dennis A; Kaufmann, William K

    2012-01-01

    This paper includes a conceptual framework for cell cycle modeling into which the experimenter can map observed data and evaluate mechanisms of cell cycle control. The basic model exhibits qualitative stability, meaning that regardless of magnitudes of system parameters its instances are guaranteed to be stable in the sense that all feasible trajectories converge to a certain trajectory. Qualitative stability can also be described by the signs of real parts of eigenvalues of the system matrix. On the biological side, the resulting model can be tuned to approximate experimental data pertaining to human fibroblast cell lines treated with ionizing radiation, with or without disabled DNA damage checkpoints. Together these properties validate a fundamental, first order systems view of cell dynamics. Classification Codes: 15A68.

  7. The island coalescence problem: scaling of reconnection in extended fluid models including higher-order moments

    CERN Document Server

    Ng, Jonathan; Hakim, Ammar; Bhattacharjee, Amitava; Stanier, Adam; Daughton, William; Wang, Liang; Germaschewski, Kai

    2015-01-01

    As modeling of collisionless magnetic reconnection in most space plasmas with realistic parameters is beyond the capability of today's simulations, due to the separation between global and kinetic length scales, it is important to establish scaling relations in model problems so as to extrapolate to realistic scales. Recently, large scale particle-in-cell (PIC) simulations of island coalescence have shown that the time averaged reconnection rate decreases with system size, while fluid systems at such large scales in the Hall regime have not been studied. Here we perform the complementary resistive MHD, Hall MHD and two fluid simulations using a ten-moment model with the same geometry. In contrast to the standard Harris sheet reconnection problem, Hall MHD is insufficient to capture the physics of the reconnection region. Additionally, motivated by the results of a recent set of hybrid simulations which show the importance of ion kinetics in this geometry, we evaluate the efficacy of the ten-moment model in re...

  8. Kinetic modelling of anaerobic hydrolysis of solid wastes, including disintegration processes.

    Science.gov (United States)

    García-Gen, Santiago; Sousbie, Philippe; Rangaraj, Ganesh; Lema, Juan M; Rodríguez, Jorge; Steyer, Jean-Philippe; Torrijos, Michel

    2015-01-01

    A methodology to estimate disintegration and hydrolysis kinetic parameters of solid wastes and validate an ADM1-based anaerobic co-digestion model is presented. Kinetic parameters of the model were calibrated from batch reactor experiments treating individually fruit and vegetable wastes (among other residues) following a new protocol for batch tests. In addition, decoupled disintegration kinetics for readily and slowly biodegradable fractions of solid wastes was considered. Calibrated parameters from batch assays of individual substrates were used to validate the model for a semi-continuous co-digestion operation treating simultaneously 5 fruit and vegetable wastes. The semi-continuous experiment was carried out in a lab-scale CSTR reactor for 15 weeks at organic loading rate ranging between 2.0 and 4.7 gVS/Ld. The model (built in Matlab/Simulink) fit to a large extent the experimental results in both batch and semi-continuous mode and served as a powerful tool to simulate the digestion or co-digestion of solid wastes.

  9. The island coalescence problem: Scaling of reconnection in extended fluid models including higher-order moments

    Energy Technology Data Exchange (ETDEWEB)

    Ng, Jonathan; Huang, Yi-Min; Hakim, Ammar; Bhattacharjee, A. [Center for Heliophysics, Princeton Plasma Physics Laboratory, Princeton, New Jersey 08540 (United States); Stanier, Adam; Daughton, William [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Wang, Liang; Germaschewski, Kai [Space Science Center and Physics Department, University of New Hampshire, Durham, New Hampshire 03824 (United States)

    2015-11-15

    As modeling of collisionless magnetic reconnection in most space plasmas with realistic parameters is beyond the capability of today's simulations, due to the separation between global and kinetic length scales, it is important to establish scaling relations in model problems so as to extrapolate to realistic scales. Recently, large scale particle-in-cell simulations of island coalescence have shown that the time averaged reconnection rate decreases with system size, while fluid systems at such large scales in the Hall regime have not been studied. Here, we perform the complementary resistive magnetohydrodynamic (MHD), Hall MHD, and two fluid simulations using a ten-moment model with the same geometry. In contrast to the standard Harris sheet reconnection problem, Hall MHD is insufficient to capture the physics of the reconnection region. Additionally, motivated by the results of a recent set of hybrid simulations which show the importance of ion kinetics in this geometry, we evaluate the efficacy of the ten-moment model in reproducing such results.

  10. EXACT SOLUTIONS FOR NONLINEAR TRANSIENT FLOW MODEL INCLUDING A QUADRATIC GRADIENT TERM

    Institute of Scientific and Technical Information of China (English)

    曹绪龙; 同登科; 王瑞和

    2004-01-01

    The models of the nonlinear radial flow for the infinite and finite reservoirs including a quadratic gradient term were presented. The exact solution was given in real space for flow equation including quadratic gradiet term for both constant-rate and constant pressure production cases in an infinite system by using generalized Weber transform. Analytical solutions for flow equation including quadratic gradient term were also obtained by using the Hankel transform for a finite circular reservoir case. Both closed and constant pressure outer boundary conditions are considered. Moreover, both constant rate and constant pressure inner boundary conditions are considered. The difference between the nonlinear pressure solution and linear pressure solution is analyzed. The difference may be reached about 8% in the long time. The effect of the quadratic gradient term in the large time well test is considered.

  11. CO{sub 2} separation by carbonate looping including additional power generation with a CO{sub 2}-H{sub 2}O steam turbine

    Energy Technology Data Exchange (ETDEWEB)

    Strelow, M.; Schlitzberger, C.; Roeder, F.; Magda, S.; Leithner, R. [Technische Universitaet Braunschweig, Institut fuer Waerme- und Brennstofftechnik, Braunschweig (Germany)

    2012-03-15

    Usually the separation of CO{sub 2} from the flue gas in power plants is connected with high efficiency losses, independent of separation technology. The reason is that the separation processes of the pre- or post-combustion capture or using an oxy-fuel process as proposed today result in additional energy consumption. But there are also sorbents, e.g., lime, that form carbonates and release heat at a temperature level of about 600 C and will be calcinated at higher temperatures (about 900 C). Integration of these processes in the design of a conventional power plant and production of additional power output by integration of another Rankine cycle using the separated CO{sub 2} and steam minimizes efficiency losses. The simulation and the results of such a CO{sub 2} capture process are described in this paper. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  12. A model for heterogeneous traffic flows including non-motorized vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Oketch, T.G.

    2001-07-01

    This study is concerned with developing a traffic flow and emissions model suitable for heterogeneous traffic streams containing motorised and non-motorised vehicles. Such streams contain vehicle types such as private cars, buses and trucks as well as bicycles, motorcycles and other vehicular forms. The model covers the different vehicle types and allows for peculiar behaviours prevalent in such streams. In addition to an existing deterministic car following rule, the model incorporates detailed lateral movement algorithm with gradual lane change manoeuvres, the decisions of which are governed by fuzzy logic rules. For determination of pollutant emissions, the travel lane was divided into finite elements and total emissions aggregated for each element depending on the vehicle speeds and types. A methodology for estimation of emission rates, based on vehicle maintenance history, for countries without reliable inventories was proposed and used to obtain emission coefficients of CO, HC, NOx and Pb emissions in Kenya. In conclusion, the model has demonstrated that heterogeneous traffic can be effectively analysed by approaches that take their peculiar characteristics into consideration. In addition, it has also provided new insight in the performance and emission patterns of heterogeneous traffic streams which can be used to formulate regulatory directives governing the usage of lanes or provision of auxiliary carriageways for slower vehicles. (orig.) [German] In dieser Arbeit wurde ein Verkehrsfluss- und Emissions-Model fuer heterogene Verkehrsstroeme entwickelt. Solche Verkehrsstroeme enthalten nicht nur motorisierte Fahrzeuge wie Pkw, Lkw, Omnibus, Motorrad usw. sondern auch nicht-motorisierte Fahrzeuge wie Fahrrad und auch besondere Fahrzeugtypen, die auf Motorraedern oder Fahrraedern basieren. Im Modell wurden auch die entsprechenden besonderen Verhaeltnisse dieser Fahrzeugtypen beruecksichtigt. Die Bewegung von Fahrzeugen wurde in zwei Dimensionen modelliert. Auf

  13. Multiple High-Fidelity Modeling Tools for Metal Additive Manufacturing Process Development Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Despite the rapid commercialization of additive manufacturing technology such as selective laser melting, SLM, there are gaps in process modeling and material...

  14. Sensitivity of an atmospheric photochemistry model to chlorine perturbations including consideration of uncertainty propagation

    Science.gov (United States)

    Stolarski, R. S.; Douglass, A. R.

    1986-01-01

    Models of stratospheric photochemistry are generally tested by comparing their predictions for the composition of the present atmosphere with measurements of species concentrations. These models are then used to make predictions of the atmospheric sensitivity to perturbations. Here the problem of the sensitivity of such a model to chlorine perturbations ranging from the present influx of chlorine-containing compounds to several times that influx is addressed. The effects of uncertainties in input parameters, including reaction rate coefficients, cross sections, solar fluxes, and boundary conditions, are evaluated using a Monte Carlo method in which the values of the input parameters are randomly selected. The results are probability distributions for present atmosheric concentrations and for calculated perturbations due to chlorine from fluorocarbons. For more than 300 Monte Carlo runs the calculated ozone perturbation for continued emission of fluorocarbons at today's rates had a mean value of -6.2 percent, with a 1-sigma width of 5.5 percent. Using the same runs but only allowing the cases in which the calculated present atmosphere values of NO, NO2, and ClO at 25 km altitude fell within the range of measurements yielded a mean ozone depletion of -3 percent, with a 1-sigma deviation of 2.2 percent. The model showed a nonlinear behavior as a function of added fluorocarbons. The mean of the Monte Carlo runs was less nonlinear than the model run using mean value of the input parameters.

  15. Health Promotion Behavior of Chinese International Students in Korea Including Acculturation Factors: A Structural Equation Model.

    Science.gov (United States)

    Kim, Sun Jung; Yoo, Il Young

    2016-03-01

    The purpose of this study was to explain the health promotion behavior of Chinese international students in Korea using a structural equation model including acculturation factors. A survey using self-administered questionnaires was employed. Data were collected from 272 Chinese students who have resided in Korea for longer than 6 months. The data were analyzed using structural equation modeling. The p value of final model is .31. The fitness parameters of the final model such as goodness of fit index, adjusted goodness of fit index, normed fit index, non-normed fit index, and comparative fit index were more than .95. Root mean square of residual and root mean square error of approximation also met the criteria. Self-esteem, perceived health status, acculturative stress and acculturation level had direct effects on health promotion behavior of the participants and the model explained 30.0% of variance. The Chinese students in Korea with higher self-esteem, perceived health status, acculturation level, and lower acculturative stress reported higher health promotion behavior. The findings can be applied to develop health promotion strategies for this population. Copyright © 2016. Published by Elsevier B.V.

  16. S5-4: Formal Modeling of Affordance in Human-Included Systems

    Directory of Open Access Journals (Sweden)

    Namhun Kim

    2012-10-01

    Full Text Available In spite of it being necessary for humans to consider modeling, analysis, and control of human-included systems, it has been considered a challenging problem because of the critical role of humans in complex systems and of humans' capability of executing unanticipated actions–both beneficial and detrimental ones. Thus, to provide systematic approaches to modeling human actions as a part of system behaviors, a formal modeling framework for human-involved systems in which humans play a controlling role based on their perceptual information is presented. The theory of affordance provides definitions of human actions and their associated properties; Finite State Automata (FSA based modeling is capable of mapping nondeterministic humans into computable components in the system representation. In this talk, we investigate the role of perception in human actions in the system operation and examine the representation of perceptual elements in affordance-based modeling formalism. The proposed framework is expected to capture the natural ways in which humans participate in the system as part of its operation. A human-machine cooperative manufacturing system control example and a human agent simulation example will be introduced for the illustrative purposes at the end of the presentation.

  17. A two-phase solid/fluid model for dense granular flows including dilatancy effects

    Science.gov (United States)

    Mangeney, Anne; Bouchut, Francois; Fernandez-Nieto, Enrique; Koné, El-Hadj; Narbona-Reina, Gladys

    2016-04-01

    Describing grain/fluid interaction in debris flows models is still an open and challenging issue with key impact on hazard assessment [{Iverson et al.}, 2010]. We present here a two-phase two-thin-layer model for fluidized debris flows that takes into account dilatancy effects. It describes the velocity of both the solid and the fluid phases, the compression/dilatation of the granular media and its interaction with the pore fluid pressure [{Bouchut et al.}, 2016]. The model is derived from a 3D two-phase model proposed by {Jackson} [2000] based on the 4 equations of mass and momentum conservation within the two phases. This system has 5 unknowns: the solid and fluid velocities, the solid and fluid pressures and the solid volume fraction. As a result, an additional equation inside the mixture is necessary to close the system. Surprisingly, this issue is inadequately accounted for in the models that have been developed on the basis of Jackson's work [{Bouchut et al.}, 2015]. In particular, {Pitman and Le} [2005] replaced this closure simply by imposing an extra boundary condition at the surface of the flow. When making a shallow expansion, this condition can be considered as a closure condition. However, the corresponding model cannot account for a dissipative energy balance. We propose here an approach to correctly deal with the thermodynamics of Jackson's model by closing the mixture equations by a weak compressibility relation following {Roux and Radjai} [1998]. This relation implies that the occurrence of dilation or contraction of the granular material in the model depends on whether the solid volume fraction is respectively higher or lower than a critical value. When dilation occurs, the fluid is sucked into the granular material, the pore pressure decreases and the friction force on the granular phase increases. On the contrary, in the case of contraction, the fluid is expelled from the mixture, the pore pressure increases and the friction force diminishes. To

  18. An extended gene protein/products Boolean network model including post-transcriptional regulation.

    Science.gov (United States)

    Benso, Alfredo; Di Carlo, Stefano; Politano, Gianfranco; Savino, Alessandro; Vasciaveo, Alessandro

    2014-05-07

    Networks Biology allows the study of complex interactions between biological systems using formal, well structured, and computationally friendly models. Several different network models can be created, depending on the type of interactions that need to be investigated. Gene Regulatory Networks (GRN) are an effective model commonly used to study the complex regulatory mechanisms of a cell. Unfortunately, given their intrinsic complexity and non discrete nature, the computational study of realistic-sized complex GRNs requires some abstractions. Boolean Networks (BNs), for example, are a reliable model that can be used to represent networks where the possible state of a node is a boolean value (0 or 1). Despite this strong simplification, BNs have been used to study both structural and dynamic properties of real as well as randomly generated GRNs. In this paper we show how it is possible to include the post-transcriptional regulation mechanism (a key process mediated by small non-coding RNA molecules like the miRNAs) into the BN model of a GRN. The enhanced BN model is implemented in a software toolkit (EBNT) that allows to analyze boolean GRNs from both a structural and a dynamic point of view. The open-source toolkit is compatible with available visualization tools like Cytoscape and allows to run detailed analysis of the network topology as well as of its attractors, trajectories, and state-space. In the paper, a small GRN built around the mTOR gene is used to demonstrate the main capabilities of the toolkit. The extended model proposed in this paper opens new opportunities in the study of gene regulation. Several of the successful researches done with the support of BN to understand high-level characteristics of regulatory networks, can now be improved to better understand the role of post-transcriptional regulation for example as a network-wide noise-reduction or stabilization mechanisms.

  19. An extended gene protein/products boolean network model including post-transcriptional regulation

    Science.gov (United States)

    2014-01-01

    Background Networks Biology allows the study of complex interactions between biological systems using formal, well structured, and computationally friendly models. Several different network models can be created, depending on the type of interactions that need to be investigated. Gene Regulatory Networks (GRN) are an effective model commonly used to study the complex regulatory mechanisms of a cell. Unfortunately, given their intrinsic complexity and non discrete nature, the computational study of realistic-sized complex GRNs requires some abstractions. Boolean Networks (BNs), for example, are a reliable model that can be used to represent networks where the possible state of a node is a boolean value (0 or 1). Despite this strong simplification, BNs have been used to study both structural and dynamic properties of real as well as randomly generated GRNs. Results In this paper we show how it is possible to include the post-transcriptional regulation mechanism (a key process mediated by small non-coding RNA molecules like the miRNAs) into the BN model of a GRN. The enhanced BN model is implemented in a software toolkit (EBNT) that allows to analyze boolean GRNs from both a structural and a dynamic point of view. The open-source toolkit is compatible with available visualization tools like Cytoscape and allows to run detailed analysis of the network topology as well as of its attractors, trajectories, and state-space. In the paper, a small GRN built around the mTOR gene is used to demonstrate the main capabilities of the toolkit. Conclusions The extended model proposed in this paper opens new opportunities in the study of gene regulation. Several of the successful researches done with the support of BN to understand high-level characteristics of regulatory networks, can now be improved to better understand the role of post-transcriptional regulation for example as a network-wide noise-reduction or stabilization mechanisms. PMID:25080304

  20. Quantum ring-polymer contraction method: Including nuclear quantum effects at no additional computational cost in comparison to ab initio molecular dynamics

    Science.gov (United States)

    John, Christopher; Spura, Thomas; Habershon, Scott; Kühne, Thomas D.

    2016-04-01

    We present a simple and accurate computational method which facilitates ab initio path-integral molecular dynamics simulations, where the quantum-mechanical nature of the nuclei is explicitly taken into account, at essentially no additional computational cost in comparison to the corresponding calculation using classical nuclei. The predictive power of the proposed quantum ring-polymer contraction method is demonstrated by computing various static and dynamic properties of liquid water at ambient conditions using density functional theory. This development will enable routine inclusion of nuclear quantum effects in ab initio molecular dynamics simulations of condensed-phase systems.

  1. Additive Manufacturing Modeling and Simulation A Literature Review for Electron Beam Free Form Fabrication

    Science.gov (United States)

    Seufzer, William J.

    2014-01-01

    Additive manufacturing is coming into industrial use and has several desirable attributes. Control of the deposition remains a complex challenge, and so this literature review was initiated to capture current modeling efforts in the field of additive manufacturing. This paper summarizes about 10 years of modeling and simulation related to both welding and additive manufacturing. The goals were to learn who is doing what in modeling and simulation, to summarize various approaches taken to create models, and to identify research gaps. Later sections in the report summarize implications for closed-loop-control of the process, implications for local research efforts, and implications for local modeling efforts.

  2. Stiffness Model of a 3-DOF Parallel Manipulator with Two Additional Legs

    Directory of Open Access Journals (Sweden)

    Guang Yu

    2014-10-01

    Full Text Available This paper investigates the stiffness modelling of a 3-DOF parallel manipulator with two additional legs. The stiffness model in six directions of the 3-DOF parallel manipulator with two additional legs is derived by performing condensation of DOFs for the joint connection and treatment of the fixed-end connections. Moreover, this modelling method is used to derive the stiffness model of the manipulator with zero/one additional legs. Two performance indices are given to compare the stiffness of the parallel manipulators with two additional legs with those of the manipulators with zero/one additional legs. The method not only can be used to derive the stiffness model of a redundant parallel manipulator, but also to model the stiffness of non-redundant parallel manipulators.

  3. General hypothesis and shell model for the synthesis of semiconductor nanotubes, including carbon nanotubes

    Science.gov (United States)

    Mohammad, S. Noor

    2010-09-01

    Semiconductor nanotubes, including carbon nanotubes, have vast potential for new technology development. The fundamental physics and growth kinetics of these nanotubes are still obscured. Various models developed to elucidate the growth suffer from limited applicability. An in-depth investigation of the fundamentals of nanotube growth has, therefore, been carried out. For this investigation, various features of nanotube growth, and the role of the foreign element catalytic agent (FECA) in this growth, have been considered. Observed growth anomalies have been analyzed. Based on this analysis, a new shell model and a general hypothesis have been proposed for the growth. The essential element of the shell model is the seed generated from segregation during growth. The seed structure has been defined, and the formation of droplet from this seed has been described. A modified definition of the droplet exhibiting adhesive properties has also been presented. Various characteristics of the droplet, required for alignment and organization of atoms into tubular forms, have been discussed. Employing the shell model, plausible scenarios for the formation of carbon nanotubes, and the variation in the characteristics of these carbon nanotubes have been articulated. The experimental evidences, for example, for the formation of shell around a core, dipole characteristics of the seed, and the existence of nanopores in the seed, have been presented. They appear to justify the validity of the proposed model. The diversities of nanotube characteristics, fundamentals underlying the creation of bamboo-shaped carbon nanotubes, and the impurity generation on the surface of carbon nanotubes have been elucidated. The catalytic action of FECA on growth has been quantified. The applicability of the proposed model to the nanotube growth by a variety of mechanisms has been elaborated. These mechanisms include the vapor-liquid-solid mechanism, the oxide-assisted growth mechanism, the self

  4. Predicting infectivity of Arbuscular Mycorrhizal fungi from soil variables using Generalized Additive Models and Generalized Linear Models

    Directory of Open Access Journals (Sweden)

    IRNANDA AIKO FIFI DJUUNA

    2010-07-01

    Full Text Available Djuuna IAF, Abbott LK, Van Niel K (2010 Predicting infectivity of Arbuscular Mycorrhizal fungi from soil variables using Generalized Additive Models and Generalized Linear Models. Biodiversitas 11: 145-150. The objective of this study was to predict the infectivity of arbuscular mycorrhizal fungi (AM fungi, from field soil based on soil properties and land use history using generalized additive models (GAMs and generalized linear models (GLMs. A total of 291 soil samples from a farm in Western Australia near Wickepin were collected and used in this study. Nine soil properties, including elevation, pH, EC, total C, total N, P, K, microbial biomass carbon, and soil texture, and land use history of the farm were used as independent variables, while the percentage of root length colonized (%RLC was used as the dependent variable. GAMs parameterized for the percent of root length colonized suggested skewed quadratic responses to soil pH and microbial biomass carbon; cubic responses to elevation and soil K; and linear responses to soil P, EC and total C. The strength of the relationship between percent root length colonized by AM fungi and environmental variables showed that only elevation, total C and microbial biomass carbon had strong relationships. In general, GAMs and GLMs models confirmed the strong relationship between infectivity of AM fungi (assessed in a glasshouse bioassay for soil collected in summer prior to the first rain of the season and soil properties.

  5. Nonlinear Acoustics FDTD method including Frequency Power Law Attenuation for Soft Tissue Modeling

    CERN Document Server

    Jiménez, Noé; Sánchez-Morcillo, Víctor; Camarena, Francisco; Hou, Yi; Konofagou, Elisa E

    2014-01-01

    This paper describes a model for nonlinear acoustic wave propagation through absorbing and weakly dispersive media, and its numerical solution by means of finite differences in time domain method (FDTD). The attenuation is based on multiple relaxation processes, and provides frequency dependent absorption and dispersion without using computational expensive convolutional operators. In this way, by using an optimization algorithm the coefficients for the relaxation processes can be obtained in order to fit a frequency power law that agrees the experimentally measured attenuation data for heterogeneous media over the typical frequency range for ultrasound medical applications. Our results show that two relaxation processes are enough to fit attenuation data for most soft tissues in this frequency range including the fundamental and the first ten harmonics. Furthermore, this model can fit experimental attenuation data that do not follow exactly a frequency power law over the frequency range of interest. The main...

  6. Particle-based modeling of heterogeneous chemical kinetics including mass transfer

    Science.gov (United States)

    Sengar, A.; Kuipers, J. A. M.; van Santen, Rutger A.; Padding, J. T.

    2017-08-01

    Connecting the macroscopic world of continuous fields to the microscopic world of discrete molecular events is important for understanding several phenomena occurring at physical boundaries of systems. An important example is heterogeneous catalysis, where reactions take place at active surfaces, but the effective reaction rates are determined by transport limitations in the bulk fluid and reaction limitations on the catalyst surface. In this work we study the macro-micro connection in a model heterogeneous catalytic reactor by means of stochastic rotation dynamics. The model is able to resolve the convective and diffusive interplay between participating species, while including adsorption, desorption, and reaction processes on the catalytic surface. Here we apply the simulation methodology to a simple straight microchannel with a catalytic strip. Dimensionless Damkohler numbers are used to comment on the spatial concentration profiles of reactants and products near the catalyst strip and in the bulk. We end the discussion with an outlook on more complicated geometries and increasingly complex reactions.

  7. Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II {beta} subunit (CSNK2B)

    Energy Technology Data Exchange (ETDEWEB)

    Albertella, M.R.; Jones, H.; Thomson, W. [Oxford Univ. (United Kingdom)] [and others

    1996-09-01

    A wide range of autoimmune and other diseases are known to be associated with the major histocompatibility complex. Many of these diseases are linked to the genes encoding the polymorphic histocompatibility complex. Many of these diseases are linked to the genes encoding the polymorphic histocompatibility antigens in the class I and class II regions, but some appear to be more strongly associated with genes in the central 1100-kb class III region, making it important to characterize this region fully for the presence of novel genes. An {approximately}220-kb segment of DNA in the class III region separating the Hsp70 (HSPA1L) and BAT1 (D6S8IE) genes, which was previously known to contain 14 genes. Genomic DNA fragments spanning the gaps between the known genes were used as probes to isolate cDNAs corresponding to five new genes within this region. Evidence from Northern blot analysis and exon trapping experiments that suggested the presence of at least two more new genes was also obtained. Partial cDNA and complete exonic genomic sequencing of one of the new genes has identified it as the casein kinase II{beta} subunit (CSNK2B). Two of the other novel genes lie within a region syntenic to that implicated in susceptibility to experimental allergic orchitis in the mouse, an autoimmune disease of the testis, and represent additional candidates for the Orch-1 locus associated with this disease. In addition, characterization of the 13-kb intergenic gap separating the RD (D6545) and G11 (D6S60E) genes has revealed the presence of a gene encoding a 1246-amino-acid polypeptide that shows significant sequence similarity to the yeast anti-viral Ski2p gene product. 49 refs., 8 figs.

  8. Models of epidemics: when contact repetition and clustering should be included

    Directory of Open Access Journals (Sweden)

    Scholz Roland W

    2009-06-01

    Full Text Available Abstract Background The spread of infectious disease is determined by biological factors, e.g. the duration of the infectious period, and social factors, e.g. the arrangement of potentially contagious contacts. Repetitiveness and clustering of contacts are known to be relevant factors influencing the transmission of droplet or contact transmitted diseases. However, we do not yet completely know under what conditions repetitiveness and clustering should be included for realistically modelling disease spread. Methods We compare two different types of individual-based models: One assumes random mixing without repetition of contacts, whereas the other assumes that the same contacts repeat day-by-day. The latter exists in two variants, with and without clustering. We systematically test and compare how the total size of an outbreak differs between these model types depending on the key parameters transmission probability, number of contacts per day, duration of the infectious period, different levels of clustering and varying proportions of repetitive contacts. Results The simulation runs under different parameter constellations provide the following results: The difference between both model types is highest for low numbers of contacts per day and low transmission probabilities. The number of contacts and the transmission probability have a higher influence on this difference than the duration of the infectious period. Even when only minor parts of the daily contacts are repetitive and clustered can there be relevant differences compared to a purely random mixing model. Conclusion We show that random mixing models provide acceptable estimates of the total outbreak size if the number of contacts per day is high or if the per-contact transmission probability is high, as seen in typical childhood diseases such as measles. In the case of very short infectious periods, for instance, as in Norovirus, models assuming repeating contacts will also behave

  9. Standardized Competencies for Parenteral Nutrition Order Review and Parenteral Nutrition Preparation, Including Compounding: The ASPEN Model.

    Science.gov (United States)

    Boullata, Joseph I; Holcombe, Beverly; Sacks, Gordon; Gervasio, Jane; Adams, Stephen C; Christensen, Michael; Durfee, Sharon; Ayers, Phil; Marshall, Neil; Guenter, Peggi

    2016-08-01

    Parenteral nutrition (PN) is a high-alert medication with a complex drug use process. Key steps in the process include the review of each PN prescription followed by the preparation of the formulation. The preparation step includes compounding the PN or activating a standardized commercially available PN product. The verification and review, as well as preparation of this complex therapy, require competency that may be determined by using a standardized process for pharmacists and for pharmacy technicians involved with PN. An American Society for Parenteral and Enteral Nutrition (ASPEN) standardized model for PN order review and PN preparation competencies is proposed based on a competency framework, the ASPEN-published interdisciplinary core competencies, safe practice recommendations, and clinical guidelines, and is intended for institutions and agencies to use with their staff.

  10. A generalized model for optimal transport of images including dissipation and density modulation

    KAUST Repository

    Maas, Jan

    2015-11-01

    © EDP Sciences, SMAI 2015. In this paper the optimal transport and the metamorphosis perspectives are combined. For a pair of given input images geodesic paths in the space of images are defined as minimizers of a resulting path energy. To this end, the underlying Riemannian metric measures the rate of transport cost and the rate of viscous dissipation. Furthermore, the model is capable to deal with strongly varying image contrast and explicitly allows for sources and sinks in the transport equations which are incorporated in the metric related to the metamorphosis approach by Trouvé and Younes. In the non-viscous case with source term existence of geodesic paths is proven in the space of measures. The proposed model is explored on the range from merely optimal transport to strongly dissipative dynamics. For this model a robust and effective variational time discretization of geodesic paths is proposed. This requires to minimize a discrete path energy consisting of a sum of consecutive image matching functionals. These functionals are defined on corresponding pairs of intensity functions and on associated pairwise matching deformations. Existence of time discrete geodesics is demonstrated. Furthermore, a finite element implementation is proposed and applied to instructive test cases and to real images. In the non-viscous case this is compared to the algorithm proposed by Benamou and Brenier including a discretization of the source term. Finally, the model is generalized to define discrete weighted barycentres with applications to textures and objects.

  11. Empirical Validation of a Thermal Model of a Complex Roof Including Phase Change Materials

    Directory of Open Access Journals (Sweden)

    Stéphane Guichard

    2015-12-01

    Full Text Available This paper deals with the empirical validation of a building thermal model of a complex roof including a phase change material (PCM. A mathematical model dedicated to PCMs based on the heat apparent capacity method was implemented in a multi-zone building simulation code, the aim being to increase the understanding of the thermal behavior of the whole building with PCM technologies. In order to empirically validate the model, the methodology is based both on numerical and experimental studies. A parametric sensitivity analysis was performed and a set of parameters of the thermal model has been identified for optimization. The use of the generic optimization program called GenOpt® coupled to the building simulation code enabled to determine the set of adequate parameters. We first present the empirical validation methodology and main results of previous work. We then give an overview of GenOpt® and its coupling with the building simulation code. Finally, once the optimization results are obtained, comparisons of the thermal predictions with measurements are found to be acceptable and are presented.

  12. Habitability of super-Earth planets around other suns: models including Red Giant Branch evolution.

    Science.gov (United States)

    von Bloh, W; Cuntz, M; Schröder, K-P; Bounama, C; Franck, S

    2009-01-01

    The unexpected diversity of exoplanets includes a growing number of super-Earth planets, i.e., exoplanets with masses of up to several Earth masses and a similar chemical and mineralogical composition as Earth. We present a thermal evolution model for a 10 Earth-mass planet orbiting a star like the Sun. Our model is based on the integrated system approach, which describes the photosynthetic biomass production and takes into account a variety of climatological, biogeochemical, and geodynamical processes. This allows us to identify a so-called photosynthesis-sustaining habitable zone (pHZ), as determined by the limits of biological productivity on the planetary surface. Our model considers solar evolution during the main-sequence stage and along the Red Giant Branch as described by the most recent solar model. We obtain a large set of solutions consistent with the principal possibility of life. The highest likelihood of habitability is found for "water worlds." Only mass-rich water worlds are able to realize pHZ-type habitability beyond the stellar main sequence on the Red Giant Branch.

  13. A transient energy function for power systems including the induction motor model

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A construction method for power system transient energy function is studied in the paper, which is simple and universal, and can unify the forms of some current energy functions. A transient energy function including the induction motor model is derived using the method. The unintegrable term is dealt with to get an approximate energy function. Simulations in a 3-bus system and in the WSCC 4-generator system verify the validity of the proposed energy function. The function can be applied to direct transient stability analysis of multi-machine large power systems and provides a tool for analysis of the interaction between the generator angle stability and the load voltage stability.

  14. A laboratory model of the aortic root flow including the coronary arteries

    Science.gov (United States)

    Querzoli, Giorgio; Fortini, Stefania; Espa, Stefania; Melchionna, Simone

    2016-08-01

    Cardiovascular flows have been extensively investigated by means of in vitro models to assess the prosthetic valve performances and to provide insight into the fluid dynamics of the heart and proximal aorta. In particular, the models for the study of the flow past the aortic valve have been continuously improved by including, among other things, the compliance of the vessel and more realistic geometries. The flow within the sinuses of Valsalva is known to play a fundamental role in the dynamics of the aortic valve since they host a recirculation region that interacts with the leaflets. The coronary arteries originate from the ostia located within two of the three sinuses, and their presence may significantly affect the fluid dynamics of the aortic root. In spite of their importance, to the extent of the authors' knowledge, coronary arteries were not included so far when modeling in vitro the transvalvular aortic flow. We present a pulse duplicator consisting of a passively pulsing ventricle, a compliant proximal aorta, and coronary arteries connected to the sinuses of Valsalva. The coronary flow is modulated by a self-regulating device mimicking the physiological mechanism, which is based on the contraction and relaxation of the heart muscle during the cardiac cycle. Results show that the model reproduces satisfyingly the coronary flow. The analysis of the time evolution of the velocity and vorticity fields within the aortic root reveals the main characteristics of the backflow generated through the aorta in order to feed the coronaries during the diastole. Experiments without coronary flow have been run for comparison. Interestingly, the lifetime of the vortex forming in the sinus of Valsalva during the systole is reduced by the presence of the coronaries. As a matter of fact, at the end of the systole, that vortex is washed out because of the suction generated by the coronary flow. Correspondingly, the valve closure is delayed and faster compared to the case with

  15. Areal rainfall estimation using moving cars - computer experiments including hydrological modeling

    Science.gov (United States)

    Rabiei, Ehsan; Haberlandt, Uwe; Sester, Monika; Fitzner, Daniel; Wallner, Markus

    2016-09-01

    The need for high temporal and spatial resolution precipitation data for hydrological analyses has been discussed in several studies. Although rain gauges provide valuable information, a very dense rain gauge network is costly. As a result, several new ideas have emerged to help estimating areal rainfall with higher temporal and spatial resolution. Rabiei et al. (2013) observed that moving cars, called RainCars (RCs), can potentially be a new source of data for measuring rain rate. The optical sensors used in that study are designed for operating the windscreen wipers and showed promising results for rainfall measurement purposes. Their measurement accuracy has been quantified in laboratory experiments. Considering explicitly those errors, the main objective of this study is to investigate the benefit of using RCs for estimating areal rainfall. For that, computer experiments are carried out, where radar rainfall is considered as the reference and the other sources of data, i.e., RCs and rain gauges, are extracted from radar data. Comparing the quality of areal rainfall estimation by RCs with rain gauges and reference data helps to investigate the benefit of the RCs. The value of this additional source of data is not only assessed for areal rainfall estimation performance but also for use in hydrological modeling. Considering measurement errors derived from laboratory experiments, the result shows that the RCs provide useful additional information for areal rainfall estimation as well as for hydrological modeling. Moreover, by testing larger uncertainties for RCs, they observed to be useful up to a certain level for areal rainfall estimation and discharge simulation.

  16. Including sugar cane in the agro-ecosystem model ORCHIDEE-STICS

    Science.gov (United States)

    Valade, A.; Vuichard, N.; Ciais, P.; Viovy, N.

    2010-12-01

    With 4 million ha currently grown for ethanol in Brazil only, approximately half the global bioethanol production in 2005 (Smeets 2008), and a devoted land area expected to expand globally in the years to come, sugar cane is at the heart of the biofuel debate. Indeed, ethanol made from biomass is currently the most widespread option for alternative transportation fuels. It was originally promoted as a carbon neutral energy resource that could bring energy independence to countries and local opportunities to farmers, until attention was drawn to its environmental and socio-economical drawbacks. It is still not clear to which extent it is a solution or a contributor to climate change mitigation. Dynamic Global Vegetation models can help address these issues and quantify the potential impacts of biofuels on ecosystems at scales ranging from on-site to global. The global agro-ecosystem model ORCHIDEE describes water, carbon and energy exchanges at the soil-atmosphere interface for a limited number of natural and agricultural vegetation types. In order to integrate agricultural management to the simulations and to capture more accurately the specificity of crops' phenology, ORCHIDEE has been coupled with the agronomical model STICS. The resulting crop-oriented vegetation model ORCHIDEE-STICS has been used so far to simulate temperate crops such as wheat, corn and soybean. As a generic ecosystem model, each grid cell can include several vegetation types with their own phenology and management practices, making it suitable to spatial simulations. Here, ORCHIDEE-STICS is altered to include sugar cane as a new agricultural Plant functional Type, implemented and parametrized using the STICS approach. An on-site calibration and validation is then performed based on biomass and flux chamber measurements in several sites in Australia and variables such as LAI, dry weight, heat fluxes and respiration are used to evaluate the ability of the model to simulate the specific

  17. A range of complex probabilistic models for RNA secondary structure prediction that includes the nearest-neighbor model and more.

    Science.gov (United States)

    Rivas, Elena; Lang, Raymond; Eddy, Sean R

    2012-02-01

    The standard approach for single-sequence RNA secondary structure prediction uses a nearest-neighbor thermodynamic model with several thousand experimentally determined energy parameters. An attractive alternative is to use statistical approaches with parameters estimated from growing databases of structural RNAs. Good results have been reported for discriminative statistical methods using complex nearest-neighbor models, including CONTRAfold, Simfold, and ContextFold. Little work has been reported on generative probabilistic models (stochastic context-free grammars [SCFGs]) of comparable complexity, although probabilistic models are generally easier to train and to use. To explore a range of probabilistic models of increasing complexity, and to directly compare probabilistic, thermodynamic, and discriminative approaches, we created TORNADO, a computational tool that can parse a wide spectrum of RNA grammar architectures (including the standard nearest-neighbor model and more) using a generalized super-grammar that can be parameterized with probabilities, energies, or arbitrary scores. By using TORNADO, we find that probabilistic nearest-neighbor models perform comparably to (but not significantly better than) discriminative methods. We find that complex statistical models are prone to overfitting RNA structure and that evaluations should use structurally nonhomologous training and test data sets. Overfitting has affected at least one published method (ContextFold). The most important barrier to improving statistical approaches for RNA secondary structure prediction is the lack of diversity of well-curated single-sequence RNA secondary structures in current RNA databases.

  18. ISOLATION OF HEPATIC OVAL CELLS FROM DIFFERENT MODEL RATS INCLUDING DIABETIC RATS

    Institute of Scientific and Technical Information of China (English)

    LU Ying-li; YE Ting-ting; XIA Fang-zhen; WANG Ning-jian; YANG Hua; CHEN Yi

    2009-01-01

    Objective To acquire oval cells (progenitor stem cells) from adult rat liver of different models including diabetic rats. Methods Thirty Sprague-Dawley (SD) rats were divided into 5 groups randomly: control, 2-acetylaminofluorene (2-AAF), 2-AAF+partial hepatectomy (PH), 2-AAF+carbon tetrachloride (CCl4), and diabetic groups. As two-step collagenase perfusion protocol of Seglen, oval cells were isolated by Percoll density gradient centrifugation. Thy1.1 positive cells were sorted by flow cytometry, and then cultured in Dulbeccos minimum Eagles medium (DMEM). Immunofluorescence staining was applied to labelling Thy1.1. Results Different rates of Thy1.1 positive oval cells were found in different rat model groups: 0.5% in 2-AAF, 0.3% in 2-hAAF+PH, 0.2% in 2-AAF+CCl4 , 0.1% in diabetic, and 0.0% in control. Isolated cells adhered to plate with fusiform or polygon as epithelial cells. Conclusion Progenitor stem cells exist in injured liver tissue including those from diabetic rats.

  19. On the modelling of semi-insulating GaAs including surface tension and bulk stresses

    Energy Technology Data Exchange (ETDEWEB)

    Dreyer, W.; Duderstadt, F.

    2004-07-01

    Necessary heat treatment of single crystal semi-insulating Gallium Arsenide (GaAs), which is deployed in micro- and opto- electronic devices, generate undesirable liquid precipitates in the solid phase. The appearance of precipitates is influenced by surface tension at the liquid/solid interface and deviatoric stresses in the solid. The central quantity for the description of the various aspects of phase transitions is the chemical potential, which can be additively decomposed into a chemical and a mechanical part. In particular the calculation of the mechanical part of the chemical potential is of crucial importance. We determine the chemical potential in the framework of the St. Venant-Kirchhoff law which gives an appropriate stress/strain relation for many solids in the small strain regime. We establish criteria, which allow the correct replacement of the St. Venant-Kirchhoff law by the simpler Hooke law. The main objectives of this study are: (i) We develop a thermo-mechanical model that describes diffusion and interface motion, which both are strongly influenced by surface tension effects and deviatoric stresses. (ii) We give an overview and outlook on problems that can be posed and solved within the framework of the model. (iii) We calculate non-standard phase diagrams, i.e. those that take into account surface tension and non-deviatoric stresses, for GaAs above 786 C, and we compare the results with classical phase diagrams without these phenomena. (orig.)

  20. Analysis of the R-symmetric supersymmetric models including quantum corrections

    CERN Document Server

    Kotlarski, Wojciech

    2016-01-01

    We study the Minimal R-symmetric Supersymmetric Standard Model (MRSSM) at the quantum level. The thesis consists of two parts. First one treats about the electroweak sector of the model. Among others, it identifies the parameter region allowed by the electroweak precision observables. Since the MRSSM contains an $SU(2)_L$-triplet with a non-zero vacuum expectation value the emphasis is put on the calculation of the $W$ boson mass. To that end, a full one-loop calculation of $m_W$ augmented with the leading two-loop SM result is presented. The region is then checked against the measurement of the Higgs boson mass. For this, the full one-loop and leading two-loop corrections to the Higgs boson mass in the MRSSM are calculated. Devised benchmark points, consistent with both of these observables, are shown to fulfill also a number of additional experimental constraints like properties of the Higgs boson(s), $b$-physics observables and vacuum stability. Correlating all of these observables allows to put bounds on ...

  1. Thermo-mechanical modeling of turbulent heat transfer in gas-solid flows including particle collisions

    Energy Technology Data Exchange (ETDEWEB)

    Mansoori, Zohreh; Saffar-Avval, Majid; Basirat-Tabrizi, Hassan; Ahmadi, Goodarz; Lain, Santiago

    2002-12-01

    A thermo-mechanical turbulence model is developed and used for predicting heat transfer in a gas-solid flow through a vertical pipe with constant wall heat flux. The new four-way interaction model makes use of the thermal k{sub {theta}}-{tau}{sub {theta}} equations, in addition to the hydrodynamic k-{tau} transport, and accounts for the particle-particle and particle-wall collisions through a Eulerian/Lagrangian formulation. The simulation results indicate that the level of thermal turbulence intensity and the heat transfer are strongly affected by the particle collisions. Inter-particle collisions attenuate the thermal turbulence intensity near the wall but somewhat amplify the temperature fluctuations in the pipe core region. The hydrodynamic-to-thermal times-scale ratio and the turbulent Prandtl number in the region near the wall increase due to the inter-particle collisions. The results also show that the use of a constant or the single-phase gas turbulent Prandtl number produces error in the thermal eddy diffusivity and thermal turbulent intensity fields. Simulation results also indicate that the inter-particle contact heat conduction during collision has no significant effect in the range of Reynolds number and particle diameter studied.

  2. Low dose radiation risks for women surviving the a-bombs in Japan: generalized additive model.

    Science.gov (United States)

    Dropkin, Greg

    2016-11-24

    Analyses of cancer mortality and incidence in Japanese A-bomb survivors have been used to estimate radiation risks, which are generally higher for women. Relative Risk (RR) is usually modelled as a linear function of dose. Extrapolation from data including high doses predicts small risks at low doses. Generalized Additive Models (GAMs) are flexible methods for modelling non-linear behaviour. GAMs are applied to cancer incidence in female low dose subcohorts, using anonymous public data for the 1958 - 1998 Life Span Study, to test for linearity, explore interactions, adjust for the skewed dose distribution, examine significance below 100 mGy, and estimate risks at 10 mGy. For all solid cancer incidence, RR estimated from 0 - 100 mGy and 0 - 20 mGy subcohorts is significantly raised. The response tapers above 150 mGy. At low doses, RR increases with age-at-exposure and decreases with time-since-exposure, the preferred covariate. Using the empirical cumulative distribution of dose improves model fit, and capacity to detect non-linear responses. RR is elevated over wide ranges of covariate values. Results are stable under simulation, or when removing exceptional data cells, or adjusting neutron RBE. Estimates of Excess RR at 10 mGy using the cumulative dose distribution are 10 - 45 times higher than extrapolations from a linear model fitted to the full cohort. Below 100 mGy, quasipoisson models find significant effects for all solid, squamous, uterus, corpus, and thyroid cancers, and for respiratory cancers when age-at-exposure > 35 yrs. Results for the thyroid are compatible with studies of children treated for tinea capitis, and Chernobyl survivors. Results for the uterus are compatible with studies of UK nuclear workers and the Techa River cohort. Non-linear models find large, significant cancer risks for Japanese women exposed to low dose radiation from the atomic bombings. The risks should be reflected in protection standards.

  3. Dynamic modelling and analysis of multi-machine power systems including wind farms

    Science.gov (United States)

    Tabesh, Ahmadreza

    2005-11-01

    This thesis introduces a small-signal dynamic model, based on a frequency response approach, for the analysis of a multi-machine power system with special focus on an induction machine based wind farm. The proposed approach is an alternative method to the conventional eigenvalue analysis method which is widely employed for small-signal dynamic analyses of power systems. The proposed modelling approach is successfully applied and evaluated for a power system that (i) includes multiple synchronous generators, and (ii) a wind farm based on either fixed-speed, variable-speed, or doubly-fed induction machine based wind energy conversion units. The salient features of the proposed method, as compared with the conventional eigenvalue analysis method, are: (i) computational efficiency since the proposed method utilizes the open-loop transfer-function matrix of the system, (ii) performance indices that are obtainable based on frequency response data and quantitatively describe the dynamic behavior of the system, and (iii) capability to formulate various wind energy conversion unit, within a wind farm, in a modular form. The developed small-signal dynamic model is applied to a set of multi-machine study systems and the results are validated based on comparison (i) with digital time-domain simulation results obtained from PSCAD/EMTDC software tool, and (ii) where applicable with eigenvalue analysis results.

  4. A Hydrological Concept including Lateral Water Flow Compatible with the Biogeochemical Model ForSAFE

    Directory of Open Access Journals (Sweden)

    Giuliana Zanchi

    2016-03-01

    Full Text Available The study presents a hydrology concept developed to include lateral water flow in the biogeochemical model ForSAFE. The hydrology concept was evaluated against data collected at Svartberget in the Vindeln Research Forest in Northern Sweden. The results show that the new concept allows simulation of a saturated and an unsaturated zone in the soil as well as water flow that reaches the stream comparable to measurements. The most relevant differences compared to streamflow measurements are that the model simulates a higher base flow in winter and lower flow peaks after snowmelt. These differences are mainly caused by the assumptions made to regulate the percolation at the bottom of the simulated soil columns. The capability for simulating lateral flows and a saturated zone in ForSAFE can greatly improve the simulation of chemical exchange in the soil and export of elements from the soil to watercourses. Such a model can help improve the understanding of how environmental changes in the forest landscape will influence chemical loads to surface waters.

  5. Modeling within-host dynamics of influenza virus infection including immune responses.

    Directory of Open Access Journals (Sweden)

    Kasia A Pawelek

    Full Text Available Influenza virus infection remains a public health problem worldwide. The mechanisms underlying viral control during an uncomplicated influenza virus infection are not fully understood. Here, we developed a mathematical model including both innate and adaptive immune responses to study the within-host dynamics of equine influenza virus infection in horses. By comparing modeling predictions with both interferon and viral kinetic data, we examined the relative roles of target cell availability, and innate and adaptive immune responses in controlling the virus. Our results show that the rapid and substantial viral decline (about 2 to 4 logs within 1 day after the peak can be explained by the killing of infected cells mediated by interferon activated cells, such as natural killer cells, during the innate immune response. After the viral load declines to a lower level, the loss of interferon-induced antiviral effect and an increased availability of target cells due to loss of the antiviral state can explain the observed short phase of viral plateau in which the viral level remains unchanged or even experiences a minor second peak in some animals. An adaptive immune response is needed in our model to explain the eventual viral clearance. This study provides a quantitative understanding of the biological factors that can explain the viral and interferon kinetics during a typical influenza virus infection.

  6. An introduction to modeling longitudinal data with generalized additive models: applications to single-case designs.

    Science.gov (United States)

    Sullivan, Kristynn J; Shadish, William R; Steiner, Peter M

    2015-03-01

    Single-case designs (SCDs) are short time series that assess intervention effects by measuring units repeatedly over time in both the presence and absence of treatment. This article introduces a statistical technique for analyzing SCD data that has not been much used in psychological and educational research: generalized additive models (GAMs). In parametric regression, the researcher must choose a functional form to impose on the data, for example, that trend over time is linear. GAMs reverse this process by letting the data inform the choice of functional form. In this article we review the problem that trend poses in SCDs, discuss how current SCD analytic methods approach trend, describe GAMs as a possible solution, suggest a GAM model testing procedure for examining the presence of trend in SCDs, present a small simulation to show the statistical properties of GAMs, and illustrate the procedure on 3 examples of different lengths. Results suggest that GAMs may be very useful both as a form of sensitivity analysis for checking the plausibility of assumptions about trend and as a primary data analysis strategy for testing treatment effects. We conclude with a discussion of some problems with GAMs and some future directions for research on the application of GAMs to SCDs.

  7. A surplus production model including environmental effects: Application to the Senegalese white shrimp stocks

    Science.gov (United States)

    Thiaw, Modou; Gascuel, Didier; Jouffre, Didier; Thiaw, Omar Thiom

    2009-12-01

    In Senegal, two stocks of white shrimp ( Penaeusnotialis) are intensively exploited, one in the north and another in the south. We used surplus production models including environmental effects to analyse their changes in abundance over the past 10 years and to estimate their Maximum Sustainable Yield (MSY) and the related fishing effort ( EMSY). First, yearly abundance indices were estimated from commercial statistics using GLM techniques. Then, two environmental indices were alternatively tested in the model: the coastal upwelling intensity from wind speeds provided by the SeaWifs database and the primary production derived from satellite infrared images of chlorophyll a. Models were fitted, with or without the environmental effect, to the 1996-2005 time series. They express stock abundance and catches as functions of the fishing effort and the environmental index (when considered). For the northern stock, fishing effort and abundance fluctuate over the period without any clear trends. The model based on the upwelling index explains 64.9% of the year-to-year variability. It shows that the stock was slightly overexploited in 2002-2003 and is now close to full exploitation. Stock abundance strongly depends on environmental conditions; consequently, the MSY estimate varies from 300 to 900 tons according to the upwelling intensity. For the southern stock, fishing effort has strongly increased over the past 10 years, while abundance has been reduced 4-fold. The environment has a significant effect on abundance but only explains a small part of the year-to-year variability. The best fit is obtained using the primary production index ( R2 = 0.75), and the stock is now significantly overfished regardless of environmental conditions. MSY varies from 1200 to 1800 tons according to environmental conditions. Finally, in northern Senegal, the upwelling is highly variable from year to year and constitutes the major factor determining productivity. In the south, hydrodynamic

  8. Environmental assessment of biofuel chains based on ecosystem modelling, including land-use change effects

    Science.gov (United States)

    Gabrielle, B.; Gagnaire, N.; Massad, R.; Prieur, V.; Python, Y.

    2012-04-01

    The potential greenhouse gas (GHG) savings resulting from the displacement of fossil energy sources by bioenergy mostly hinges on the uncertainty on the magnitude of nitrous oxide (N2O) emissions from arable soils occuring during feedstock production. These emissions are broadly related to fertilizer nitrogen input rates, but largely controlled by soil and climate factors which makes their estimation highly uncertain. Here, we set out to improve estimates of N2O emissions from bioenergy feedstocks by using ecosystem models and measurements and modeling of atmospheric N2O in the greater Paris (France) area. Ground fluxes were measured in two locations to assess the effect of soil type and management, crop type (including lignocellulosics such as triticale, switchgrass and miscanthus), and climate on N2O emission rates and dynamics. High-resolution maps of N2O emissions were generated over the Ile-de-France region (around Paris) with two ecosystem models using geographical databases on soils, weather data, land-use and crop management. The models were tested against ground flux measurements and the emission maps were fed into the atmospheric chemistry-transport model CHIMERE. The maps were tested by comparing the CHIMERE simulations with time series of N2O concentrations measured at various heights above the ground in two locations in 2007. The emissions of N2O, as integrated over the region, were used in a life-cycle assessment of representative biofuel pathways: bioethanol from wheat and sugar-beet (1st generation), and miscanthus (2nd generation chain); bio-diesel from oilseed rape. Effects related to direct and indirect land-use changes (in particular on soil carbon stocks) were also included in the assessment based on various land-use scenarios and literature references. The potential deployment of miscanthus was simulated by assuming it would be grown on the current sugar-beet growing area in Ile-de-France, or by converting land currently under permanent fallow

  9. Grain-Size Based Additivity Models for Scaling Multi-rate Uranyl Surface Complexation in Subsurface Sediments

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xiaoying; Liu, Chongxuan; Hu, Bill X.; Hu, Qinhong

    2016-07-01

    This study statistically analyzed a grain-size based additivity model that has been proposed to scale reaction rates and parameters from laboratory to field. The additivity model assumed that reaction properties in a sediment including surface area, reactive site concentration, reaction rate, and extent can be predicted from field-scale grain size distribution by linearly adding reaction properties for individual grain size fractions. This study focused on the statistical analysis of the additivity model with respect to reaction rate constants using multi-rate uranyl (U(VI)) surface complexation reactions in a contaminated sediment as an example. Experimental data of rate-limited U(VI) desorption in a stirred flow-cell reactor were used to estimate the statistical properties of multi-rate parameters for individual grain size fractions. The statistical properties of the rate constants for the individual grain size fractions were then used to analyze the statistical properties of the additivity model to predict rate-limited U(VI) desorption in the composite sediment, and to evaluate the relative importance of individual grain size fractions to the overall U(VI) desorption. The result indicated that the additivity model provided a good prediction of the U(VI) desorption in the composite sediment. However, the rate constants were not directly scalable using the additivity model, and U(VI) desorption in individual grain size fractions have to be simulated in order to apply the additivity model. An approximate additivity model for directly scaling rate constants was subsequently proposed and evaluated. The result found that the approximate model provided a good prediction of the experimental results within statistical uncertainty. This study also found that a gravel size fraction (2-8mm), which is often ignored in modeling U(VI) sorption and desorption, is statistically significant to the U(VI) desorption in the sediment.

  10. The summary of FUT1 and FUT2 genotyping analysis in Chinese para-Bombay individuals including additional nine probands from Guangzhou in China.

    Science.gov (United States)

    Luo, Guangping; Wei, Ling; Wang, Zhen; Luo, Hong; Zhao, Yang; Zhang, Runqing; Mo, Chunyan; Ji, Yanli

    2013-12-01

    The para-Bombay phenotype is characterized by the absence or weak expression of ABH antigens on the surface of red blood cells, but normal expression in saliva. The para-Bombay phenotype of the nine Chinese probands was identified by standard serologic techniques. The coding regions of FUT1 and FUT2 genes were amplified by polymerase chain reaction and then directly sequenced. ABO genotyping was performed by polymerase chain reaction with sequence-specific priming method. The FUT1 and FUT2 genotypes and the distribution in all reported Chinese para-Bombay individuals including our study were also summarized. Five FUT1 genotypes, h1h3 (n = 3), h1h2 (n = 3), h1h1 (n = 1), h3h3 (n = 1), and h2h3 (n = 1), and three functional FUT2 genotypes, Se(357) Se(357) (n = 4), Se(357) Se(357, 716) (n = 4), and Se(357) Se(357, 385) (n = 1) described before were identified in nine probands. The review of the literature shows that a total of 17 FUT1 alleles and four FUT2 alleles (Se(357), Se(357,716), Se(357 385), Se) have been identified in Chinese para-Bombay individuals. The four FUT1 alleles, h1 (547delAG), h2 (880delTT), h3 (C658T), and h4 (C35T; A980C) are most prevalent, which account for more than 90% of all allele counts and are essential to be involved when developing para-Bombay genotyping kit for Chinese. © 2013 American Association of Blood Banks.

  11. Additive Hazard Regression Models: An Application to the Natural History of Human Papillomavirus

    Directory of Open Access Journals (Sweden)

    Xianhong Xie

    2013-01-01

    Full Text Available There are several statistical methods for time-to-event analysis, among which is the Cox proportional hazards model that is most commonly used. However, when the absolute change in risk, instead of the risk ratio, is of primary interest or when the proportional hazard assumption for the Cox proportional hazards model is violated, an additive hazard regression model may be more appropriate. In this paper, we give an overview of this approach and then apply a semiparametric as well as a nonparametric additive model to a data set from a study of the natural history of human papillomavirus (HPV in HIV-positive and HIV-negative women. The results from the semiparametric model indicated on average an additional 14 oncogenic HPV infections per 100 woman-years related to CD4 count < 200 relative to HIV-negative women, and those from the nonparametric additive model showed an additional 40 oncogenic HPV infections per 100 women over 5 years of followup, while the estimated hazard ratio in the Cox model was 3.82. Although the Cox model can provide a better understanding of the exposure disease association, the additive model is often more useful for public health planning and intervention.

  12. Models that include supercoiling of topological domains reproduce several known features of interphase chromosomes.

    Science.gov (United States)

    Benedetti, Fabrizio; Dorier, Julien; Burnier, Yannis; Stasiak, Andrzej

    2014-03-01

    Understanding the structure of interphase chromosomes is essential to elucidate regulatory mechanisms of gene expression. During recent years, high-throughput DNA sequencing expanded the power of chromosome conformation capture (3C) methods that provide information about reciprocal spatial proximity of chromosomal loci. Since 2012, it is known that entire chromatin in interphase chromosomes is organized into regions with strongly increased frequency of internal contacts. These regions, with the average size of ∼1 Mb, were named topological domains. More recent studies demonstrated presence of unconstrained supercoiling in interphase chromosomes. Using Brownian dynamics simulations, we show here that by including supercoiling into models of topological domains one can reproduce and thus provide possible explanations of several experimentally observed characteristics of interphase chromosomes, such as their complex contact maps.

  13. Modeling and analysis of overmodulation in erbium-doped fiber amplifiers including amplified spontaneous emission

    Science.gov (United States)

    Sharma, Reena; Raghuwanshi, Sanjeev Kumar

    2017-02-01

    Line surveillance and management information in erbium-doped fiber amplifiers (EDFAs) can be broadcast by modulating the amplitude of the low-frequency lightwave information signal, the process termed as overmodulation in the literature. This paper presents systematic solutions for the overmodulated pump and information signal transfer functions for EDFA. It includes amplified spontaneous emission (ASE) that has an impact on outcomes in the high-gain system. To the extent of our belief, the methodical model simulated with the current approach leads to a distinct perspective of an outcome in the respective field. The test bed described here is realistic. It specifically represents the overmodulation behavior in an EDFA under the influence of ASE.

  14. An MINLP Model that Includes the Effect of Temperature and Composition on Property Balances for Mass Integration Networks

    Directory of Open Access Journals (Sweden)

    Arturo Jiménez-Gutiérrez

    2014-08-01

    Full Text Available The synthesis of water networks based on properties has commonly ignored the effect of temperature on the property balances that are part of the formulation. When wide differences of temperatures are observed within the process, such an effect might yield significant errors in the application of conventional property balances. In this work, a framework for the development of water networks that include temperature effects on property balances is presented. The approach is based on the inclusion of constants in the property operators that are commonly used to carry out the property balances. An additional term to take care of composition effects is also included. The resulting approach is embedded into a formulation based on a mixed-integer nonlinear programming model for the design of water networks. A case study is presented that shows that the proposed approach yields an improvement in the prediction of the resulting properties for the integrated network, thus affecting the optimal solution.

  15. Modeling protein density of states: additive hydrophobic effects are insufficient for calorimetric two-state cooperativity.

    Science.gov (United States)

    Chan, H S

    2000-09-01

    A well-established experimental criterion for two-state thermodynamic cooperativity in protein folding is that the van't Hoff enthalpy DeltaH(vH) around the transition midpoint is equal, or very nearly so, to the calorimetric enthalpy DeltaH(cal) of the entire transition. This condition is satisfied by many small proteins. We use simple lattice models to provide a statistical mechanical framework to elucidate how this calorimetric two-state picture may be reconciled with the hierarchical multistate scenario emerging from recent hydrogen exchange experiments. We investigate the feasibility of using inverse Laplace transforms to recover the underlying density of states (i.e., enthalpy distribution) from calorimetric data. We find that the constraint imposed by DeltaH(vH)/DeltaH(cal) approximately 1 on densities of states of proteins is often more stringent than other "two-state" criteria proposed in recent theoretical studies. In conjunction with reasonable assumptions, the calorimetric two-state condition implies a narrow distribution of denatured-state enthalpies relative to the overall enthalpy difference between the native and the denatured conformations. This requirement does not always correlate with simple definitions of "sharpness" of a transition and has important ramifications for theoretical modeling. We find that protein models that assume capillarity cooperativity can exhibit overall calorimetric two-state-like behaviors. However, common heteropolymer models based on additive hydrophobic-like interactions, including highly specific two-dimensional Gō models, fail to produce proteinlike DeltaH(vH)/DeltaH(cal) approximately 1. A simple model is constructed to illustrate a proposed scenario in which physically plausible local and nonlocal cooperative terms, which mimic helical cooperativity and environment-dependent hydrogen bonding strength, can lead to thermodynamic behaviors closer to experiment. Our results suggest that proteinlike thermodynamic

  16. Exergoeconomic performance optimization for a steady-flow endoreversible refrigeration model including six typical cycles

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Lingen; Kan, Xuxian; Sun, Fengrui; Wu, Feng [College of Naval Architecture and Power, Naval University of Engineering, Wuhan 430033 (China)

    2013-07-01

    The operation of a universal steady flow endoreversible refrigeration cycle model consisting of a constant thermal-capacity heating branch, two constant thermal-capacity cooling branches and two adiabatic branches is viewed as a production process with exergy as its output. The finite time exergoeconomic performance optimization of the refrigeration cycle is investigated by taking profit rate optimization criterion as the objective. The relations between the profit rate and the temperature ratio of working fluid, between the COP (coefficient of performance) and the temperature ratio of working fluid, as well as the optimal relation between profit rate and the COP of the cycle are derived. The focus of this paper is to search the compromised optimization between economics (profit rate) and the utilization factor (COP) for endoreversible refrigeration cycles, by searching the optimum COP at maximum profit, which is termed as the finite-time exergoeconomic performance bound. Moreover, performance analysis and optimization of the model are carried out in order to investigate the effect of cycle process on the performance of the cycles using numerical example. The results obtained herein include the performance characteristics of endoreversible Carnot, Diesel, Otto, Atkinson, Dual and Brayton refrigeration cycles.

  17. Exergoeconomic performance optimization for a steady-flow endoreversible refrigeration model including six typical cycles

    Directory of Open Access Journals (Sweden)

    Lingen Chen, Xuxian Kan, Fengrui Sun, Feng Wu

    2013-01-01

    Full Text Available The operation of a universal steady flow endoreversible refrigeration cycle model consisting of a constant thermal-capacity heating branch, two constant thermal-capacity cooling branches and two adiabatic branches is viewed as a production process with exergy as its output. The finite time exergoeconomic performance optimization of the refrigeration cycle is investigated by taking profit rate optimization criterion as the objective. The relations between the profit rate and the temperature ratio of working fluid, between the COP (coefficient of performance and the temperature ratio of working fluid, as well as the optimal relation between profit rate and the COP of the cycle are derived. The focus of this paper is to search the compromised optimization between economics (profit rate and the utilization factor (COP for endoreversible refrigeration cycles, by searching the optimum COP at maximum profit, which is termed as the finite-time exergoeconomic performance bound. Moreover, performance analysis and optimization of the model are carried out in order to investigate the effect of cycle process on the performance of the cycles using numerical example. The results obtained herein include the performance characteristics of endoreversible Carnot, Diesel, Otto, Atkinson, Dual and Brayton refrigeration cycles.

  18. Challenges of including nitrogen effects on decomposition in earth system models

    Science.gov (United States)

    Hobbie, S. E.

    2011-12-01

    Despite the importance of litter decomposition for ecosystem fertility and carbon balance, key uncertainties remain about how this fundamental process is affected by nitrogen (N) availability. Nevertheless, resolving such uncertainties is critical for mechanistic inclusion of such processes in earth system models, towards predicting the ecosystem consequences of increased anthropogenic reactive N. Towards that end, we have conducted a series of experiments examining nitrogen effects on litter decomposition. We found that both substrate N and externally supplied N (regardless of form) accelerated the initial decomposition rate. Faster initial decomposition rates were linked to the higher activity of carbohydrate-degrading enzymes associated with externally supplied N and the greater relative abundances of Gram negative and Gram positive bacteria associated with green leaves and externally supplied organic N (assessed using phospholipid fatty acid analysis, PLFA). By contrast, later in decomposition, externally supplied N slowed decomposition, increasing the fraction of slowly decomposing litter and reducing lignin-degrading enzyme activity and relative abundances of Gram negative and Gram positive bacteria. Our results suggest that elevated atmospheric N deposition may have contrasting effects on the dynamics of different soil carbon pools, decreasing mean residence times of active fractions comprising very fresh litter, while increasing those of more slowly decomposing fractions including more processed litter. Incorporating these contrasting effects of N on decomposition processes into models is complicated by lingering uncertainties about how these effects generalize across ecosystems and substrates.

  19. A Model for One-Dimensional Coherent Synchrotron Radiation including Short-Range Effects

    CERN Document Server

    Ryne, Robert D; Qiang, Ji; Yampolsky, Nikolai

    2012-01-01

    A new model is presented for simulating coherent synchrotron radiation (CSR) in one dimension. The method is based on convolving an integrated Green function (IGF) with the longitudinal charge density. Since it is based on an IGF, the accuracy of this approach is determined by how well one resolves the charge density and not by resolving the single particle wake function. Since short-range wakefield effects are included analytically, the approach can be much more efficient than ordinary (non-IGF) approaches in situations where the wake function and charge density have disparate spatial scales. Two cases are presented: one derived from the full wake including short-range effects, and one derived from the asymptotic wake. In the latter case the algorithm contains the same physics as others based on the asymptotic approximation, but requires only the line charge density and not its derivative. Examples are presented that illustrate the limitations of the asymptotic-wake approximation, and that illustrate how mic...

  20. INTERIOR MODELS OF SATURN: INCLUDING THE UNCERTAINTIES IN SHAPE AND ROTATION

    Energy Technology Data Exchange (ETDEWEB)

    Helled, Ravit [Department of Geophysics, Atmospheric and Planetary Sciences, Tel-Aviv University, Tel-Aviv (Israel); Guillot, Tristan [Universite de Nice-Sophia Antipolis, Observatoire de la Cote d' Azur, CNRS UMR 7293, BP 4229, F-06304 Nice (France)

    2013-04-20

    The accurate determination of Saturn's gravitational coefficients by Cassini could provide tighter constraints on Saturn's internal structure. Also, occultation measurements provide important information on the planetary shape which is often not considered in structure models. In this paper we explore how wind velocities and internal rotation affect the planetary shape and the constraints on Saturn's interior. We show that within the geodetic approach the derived physical shape is insensitive to the assumed deep rotation. Saturn's re-derived equatorial and polar radii at 100 mbar are found to be 54,445 {+-} 10 km and 60,365 {+-} 10 km, respectively. To determine Saturn's interior, we use one-dimensional three-layer hydrostatic structure models and present two approaches to include the constraints on the shape. These approaches, however, result in only small differences in Saturn's derived composition. The uncertainty in Saturn's rotation period is more significant: with Voyager's 10{sup h}39{sup m} period, the derived mass of heavy elements in the envelope is 0-7 M{sub Circled-Plus }. With a rotation period of 10{sup h}32{sup m}, this value becomes <4 M{sub Circled-Plus }, below the minimum mass inferred from spectroscopic measurements. Saturn's core mass is found to depend strongly on the pressure at which helium phase separation occurs, and is estimated to be 5-20 M{sub Circled-Plus }. Lower core masses are possible if the separation occurs deeper than 4 Mbar. We suggest that the analysis of Cassini's radio occultation measurements is crucial to test shape models and could lead to constraints on Saturn's rotation profile and departures from hydrostatic equilibrium.

  1. Including oxygen enhancement ratio in ion beam treatment planning: model implementation and experimental verification

    Science.gov (United States)

    Scifoni, E.; Tinganelli, W.; Weyrather, W. K.; Durante, M.; Maier, A.; Krämer, M.

    2013-06-01

    We present a method for adapting a biologically optimized treatment planning for particle beams to a spatially inhomogeneous tumor sensitivity due to hypoxia, and detected e.g., by PET functional imaging. The TRiP98 code, established treatment planning system for particles, has been extended for including explicitly the oxygen enhancement ratio (OER) in the biological effect calculation, providing the first set up of a dedicated ion beam treatment planning approach directed to hypoxic tumors, TRiP-OER, here reported together with experimental tests. A simple semi-empirical model for calculating the OER as a function of oxygen concentration and dose averaged linear energy transfer, generating input tables for the program is introduced. The code is then extended in order to import such tables coming from the present or alternative models, accordingly and to perform forward and inverse planning, i.e., predicting the survival response of differently oxygenated areas as well as optimizing the required dose for restoring a uniform survival effect in the whole irradiated target. The multiple field optimization results show how the program selects the best beam components for treating the hypoxic regions. The calculations performed for different ions, provide indications for the possible clinical advantages of a multi-ion treatment. Finally the predictivity of the code is tested through dedicated cell culture experiments on extended targets irradiation using specially designed hypoxic chambers, providing a qualitative agreement, despite some limits in full survival calculations arising from the RBE assessment. The comparison of the predictions resulting by using different model tables are also reported.

  2. A nozzle boundary layer model including the subsonic sublayer usable for determining boundary layer effects on plume flowfields

    Science.gov (United States)

    Cooper, B. P., Jr.

    1979-01-01

    A model for the boundary layer at the exit plane of a rocket nozzle was developed which, unlike most previous models, includes the subsonic sublayer. The equations for the flow near the nozzle exit plane are presented and the method by which the subsonic sublayer transitions to supersonic flow in the plume is described. The resulting model describes the entire boundary layer and can be used to provide a startline for method-of-characteristics calculations of plume flowfields. The model was incorporated into a method of characteristics computer program and comparisons of computed results to experimental data show good agreement. The data used in the comparisons were obtained in tests in which mass fluxes from a 22.2-N (5 lbf) thrust engine were measured at angles off the nozzle centerline of up to 150 deg. Additional comparisons were made with data obtained during tests of a 0.89-N (0.2 lbr) monopropellant thruster and from the OH-64 space shuttle heating tests. The agreement with the data indicates that the model can be used for calculating plume backflow properties.

  3. Modeling the flux of metabolites in the juvenile hormone biosynthesis pathway using generalized additive models and ordinary differential equations.

    Science.gov (United States)

    Martínez-Rincón, Raúl O; Rivera-Pérez, Crisalejandra; Diambra, Luis; Noriega, Fernando G

    2017-01-01

    Juvenile hormone (JH) regulates development and reproductive maturation in insects. The corpora allata (CA) from female adult mosquitoes synthesize fluctuating levels of JH, which have been linked to the ovarian development and are influenced by nutritional signals. The rate of JH biosynthesis is controlled by the rate of flux of isoprenoids in the pathway, which is the outcome of a complex interplay of changes in precursor pools and enzyme levels. A comprehensive study of the changes in enzymatic activities and precursor pool sizes have been previously reported for the mosquito Aedes aegypti JH biosynthesis pathway. In the present studies, we used two different quantitative approaches to describe and predict how changes in the individual metabolic reactions in the pathway affect JH synthesis. First, we constructed generalized additive models (GAMs) that described the association between changes in specific metabolite concentrations with changes in enzymatic activities and substrate concentrations. Changes in substrate concentrations explained 50% or more of the model deviances in 7 of the 13 metabolic steps analyzed. Addition of information on enzymatic activities almost always improved the fitness of GAMs built solely based on substrate concentrations. GAMs were validated using experimental data that were not included when the model was built. In addition, a system of ordinary differential equations (ODE) was developed to describe the instantaneous changes in metabolites as a function of the levels of enzymatic catalytic activities. The results demonstrated the ability of the models to predict changes in the flux of metabolites in the JH pathway, and can be used in the future to design and validate experimental manipulations of JH synthesis.

  4. Modeling the flux of metabolites in the juvenile hormone biosynthesis pathway using generalized additive models and ordinary differential equations

    Science.gov (United States)

    Martínez-Rincón, Raúl O.; Rivera-Pérez, Crisalejandra; Diambra, Luis; Noriega, Fernando G.

    2017-01-01

    Juvenile hormone (JH) regulates development and reproductive maturation in insects. The corpora allata (CA) from female adult mosquitoes synthesize fluctuating levels of JH, which have been linked to the ovarian development and are influenced by nutritional signals. The rate of JH biosynthesis is controlled by the rate of flux of isoprenoids in the pathway, which is the outcome of a complex interplay of changes in precursor pools and enzyme levels. A comprehensive study of the changes in enzymatic activities and precursor pool sizes have been previously reported for the mosquito Aedes aegypti JH biosynthesis pathway. In the present studies, we used two different quantitative approaches to describe and predict how changes in the individual metabolic reactions in the pathway affect JH synthesis. First, we constructed generalized additive models (GAMs) that described the association between changes in specific metabolite concentrations with changes in enzymatic activities and substrate concentrations. Changes in substrate concentrations explained 50% or more of the model deviances in 7 of the 13 metabolic steps analyzed. Addition of information on enzymatic activities almost always improved the fitness of GAMs built solely based on substrate concentrations. GAMs were validated using experimental data that were not included when the model was built. In addition, a system of ordinary differential equations (ODE) was developed to describe the instantaneous changes in metabolites as a function of the levels of enzymatic catalytic activities. The results demonstrated the ability of the models to predict changes in the flux of metabolites in the JH pathway, and can be used in the future to design and validate experimental manipulations of JH synthesis. PMID:28158248

  5. Concentration addition, independent action and generalized concentration addition models for mixture effect prediction of sex hormone synthesis in vitro

    DEFF Research Database (Denmark)

    Hadrup, Niels; Taxvig, Camilla; Pedersen, Mikael;

    2013-01-01

    , antagonism was observed for effects of Mixture 2 on this hormone. The mixtures contained chemicals exerting only limited maximal effects. This hampered prediction by the CA and IA models, whereas the GCA model could be used to predict a full dose response curve. Regarding effects on progesterone...

  6. Grain-Size Based Additivity Models for Scaling Multi-rate Uranyl Surface Complexation in Subsurface Sediments

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xiaoying; Liu, Chongxuan; Hu, Bill X.; Hu, Qinhong

    2016-07-31

    The additivity model assumed that field-scale reaction properties in a sediment including surface area, reactive site concentration, and reaction rate can be predicted from field-scale grain-size distribution by linearly adding reaction properties estimated in laboratory for individual grain-size fractions. This study evaluated the additivity model in scaling mass transfer-limited, multi-rate uranyl (U(VI)) surface complexation reactions in a contaminated sediment. Experimental data of rate-limited U(VI) desorption in a stirred flow-cell reactor were used to estimate the statistical properties of the rate constants for individual grain-size fractions, which were then used to predict rate-limited U(VI) desorption in the composite sediment. The result indicated that the additivity model with respect to the rate of U(VI) desorption provided a good prediction of U(VI) desorption in the composite sediment. However, the rate constants were not directly scalable using the additivity model. An approximate additivity model for directly scaling rate constants was subsequently proposed and evaluated. The result found that the approximate model provided a good prediction of the experimental results within statistical uncertainty. This study also found that a gravel-size fraction (2 to 8 mm), which is often ignored in modeling U(VI) sorption and desorption, is statistically significant to the U(VI) desorption in the sediment.

  7. Regional modelling of future African climate north of 15S including greenhouse warming and land degradation

    Energy Technology Data Exchange (ETDEWEB)

    Paeth, H. [Geographical Institute, University of Wuerzburg, Am Hubland, 97074 Wuerzburg (Germany); Thamm, H.P. [Geographical Institute, University of Bonn, Bonn (Germany)

    2007-08-15

    Previous studies have highlighted the crucial role of land degradation in tropical African climate. This effect urgently has to be taken into account when predicting future African climate under enhanced greenhouse conditions. Here, we present time slice experiments of African climate until 2025, using a high-resolution regional climate model. A supposable scenario of future land use changes, involving vegetation loss and soil degradation, is prescribed simultaneously with increasing greenhouse-gas concentrations in order to detect, where the different forcings counterbalance or reinforce each other. This proceeding allows us to define the regions of highest vulnerability with respect to future freshwater availability and food security in tropical and subtropical Africa and may provide a decision basis for political measures. The model simulates a considerable reduction in precipitation amount until 2025 over most of tropical Africa, amounting to partly more than 500 mm (20-40% of the annual sum), particularly in the Congo Basin and the Sahel Zone. The change is strongest in boreal summer and basically reflects the pattern of maximum vegetation cover during the seasonal cycle. The related change in the surface energy fluxes induces a substantial near-surface warming by up to 7C. According to the modified temperature gradients over tropical Africa, the summer monsoon circulation intensifies and transports more humid air masses into the southern part of West Africa. This humidifying effect is overcompensated by a remarkable decrease in surface evaporation, leading to the overall drying tendency over most of Africa. Extreme daily rainfall events become stronger in autumn but less intense in spring. Summer and autumn appear to be characterized by more severe heat waves over Subsaharan West Africa. In addition, the Tropical Easterly Jet is weakening, leading to enhanced drought conditions in the Sahel Zone. All these results suggest that the local impact of land

  8. Effects of additional food in a delayed predator-prey model.

    Science.gov (United States)

    Sahoo, Banshidhar; Poria, Swarup

    2015-03-01

    We examine the effects of supplying additional food to predator in a gestation delay induced predator-prey system with habitat complexity. Additional food works in favor of predator growth in our model. Presence of additional food reduces the predatory attack rate to prey in the model. Supplying additional food we can control predator population. Taking time delay as bifurcation parameter the stability of the coexisting equilibrium point is analyzed. Hopf bifurcation analysis is done with respect to time delay in presence of additional food. The direction of Hopf bifurcations and the stability of bifurcated periodic solutions are determined by applying the normal form theory and the center manifold theorem. The qualitative dynamical behavior of the model is simulated using experimental parameter values. It is observed that fluctuations of the population size can be controlled either by supplying additional food suitably or by increasing the degree of habitat complexity. It is pointed out that Hopf bifurcation occurs in the system when the delay crosses some critical value. This critical value of delay strongly depends on quality and quantity of supplied additional food. Therefore, the variation of predator population significantly effects the dynamics of the model. Model results are compared with experimental results and biological implications of the analytical findings are discussed in the conclusion section.

  9. Mathematical and numerical model of directional solidification including initial and terminal transients of the process

    Directory of Open Access Journals (Sweden)

    W. Kapturkiewicz

    2008-12-01

    Full Text Available The, developed in this study, simple model and numerical solution of diffusion growth of the solid phase under the conditions of directional solidification allow for the effect of constituent diffusion in both liquid and solid phase and assume the process run in which (like in reality the preset parameter is the velocity of sample (pulling velocity at a preset temperature gradient. The solid/liquid interface velocity is not the process parameter (like it is in numerous other solutions proposed so far but a function of this process. The effect of convection outside the diffusion layer has been included in mass balance under the assumption that in the zone of convection the mixing is complete. The above assumptions enabled solving the kinetics of growth of the solid phase (along with the diffusion field in solid and liquid phase under the conditions of diffusion well reflecting the process run starting with the initial transient state, going through the steady state period in central part of the casting, and ending in a terminal transient state. In the numerical solution obtained by the finite difference method with variable grid dimensions, the error of the mass control balance over the whole process range was 1 - 2 %.

  10. Modelling anaerobic digestion in an industrial biogas digester: Application of lactate-including ADM1 model (Part II).

    Science.gov (United States)

    Satpathy, Preseela; Biernacki, Piotr; Cypionka, Heribert; Steinigeweg, Sven

    2016-12-05

    A modified Anaerobic Digestion Model No. 1 (ADM1xp) including lactate was applied to a full-scale biogas plant. This model considers monosaccharides to degrade through lactic acid, which further degrades majorly into acetate followed by propionate and butyrate. Experimental data were derived from the previous works in the same laboratory, and the proposed parameters were validated against batch experiments. After successful validation, the biogas plant bearing a fermenter size of 7 dam(3) and operated with food waste and cattle manure was simulated. The biogas production and methane content were reliably simulated, and a good fit could be obtained against the experimental data with an average difference of less than 1%. When compared to the original ADM1 model, the performance of the lactate-incorporated model was found to be improved. Inclusion of lactate as a parameter in the ADM1xp model is recommended for an increased sensitivity and enhanced prediction principally for systems dealing with high carbohydrate and lactate loads.

  11. ADDITIVE-MULTIPLICATIVE MODEL FOR RISK ESTIMATION IN THE PRODUCTION OF ROCKET AND SPACE TECHNICS

    Directory of Open Access Journals (Sweden)

    Orlov A. I.

    2014-10-01

    Full Text Available For the first time we have developed a general additive-multiplicative model of the risk estimation (to estimate the probabilities of risk events. In the two-level system in the lower level the risk estimates are combined additively, on the top – in a multiplicative way. Additive-multiplicative model was used for risk estimation for (1 implementation of innovative projects at universities (with external partners, (2 the production of new innovative products, (3 the projects for creation of rocket and space equipmen

  12. Numerical modelling of seawater intrusion in Shenzhen (China) using a 3D densitydependent model including tidal effects

    Indian Academy of Sciences (India)

    Wei Lu; Qingchun Yang; Jordi D Martín; Ricardo Juncosa

    2013-04-01

    During the 1990s, groundwater overexploitation has resulted in seawater intrusion in the coastal aquifer of the Shenzhen city, China. Although water supply facilities have been improved and alleviated seawater intrusion in recent years, groundwater overexploitation is still of great concern in some local areas. In this work we present a three-dimensional density-dependent numerical model developed with the FEFLOW code, which is aimed at simulating the extent of seawater intrusion while including tidal effects and different groundwater pumping scenarios. Model calibration, using waterheads and reported chloride concentration, has been performed based on the data from 14 boreholes, which were monitored from May 2008 to December 2009. A fairly good fitness between the observed and computed values was obtained by a manual trial-and-error method. Model prediction has been carried out forward 3 years with the calibrated model taking into account high, medium and low tide levels and different groundwater exploitation schemes. The model results show that tide-induced seawater intrusion significantly affects the groundwater levels and concentrations near the estuarine of the Dasha river, which implies that an important hydraulic connection exists between this river and groundwater, even considering that some anti-seepage measures were taken in the river bed. Two pumping scenarios were considered in the calibrated model in order to predict the future changes in the water levels and chloride concentration. The numerical results reveal a decreased tendency of seawater intrusion if groundwater exploitation does not reach an upper bound of about 1.32 × 104 m3/d. The model results provide also insights for controlling seawater intrusion in such coastal aquifer systems.

  13. ETM documentation update – including modelling conventions and manual for software tools

    DEFF Research Database (Denmark)

    Grohnheit, Poul Erik

    , it summarises the work done during 2013, and it also contains presentations for promotion of fusion as a future element in the electricity generation mix and presentations for the modelling community concerning model development and model documentation – in particular for TIAM collaboration workshops....

  14. Modelling stress-dependent permeability in fractured rock including effects of propagating and bending fractures

    NARCIS (Netherlands)

    Latham, J.P.; Xiang, J.; Belayneh, M.; Nick, H.M.; Tsang, C.F.; Blunt, M.J.

    2013-01-01

    The influence of in-situ stresses on flow processes in fractured rock is investigated using a novel modelling approach. The combined finite-discrete element method (FEMDEM) is used to model the deformation of a fractured rock mass. The fracture wall displacements and aperture changes are modelled in

  15. A sub-circuit MOSFET model with a wide temperature range including cryogenic temperature*

    Institute of Scientific and Technical Information of China (English)

    Jia Kan; Sun Weifeng; Shi Longxing

    2011-01-01

    A sub-circuit SPICE model ofa MOSFET for low temperature operation is presented. Two resistors are introduced for the freeze-out effect, and the explicit behavioral models are developed for them. The model can be used in a wide temperature range covering both cryogenic temperature and regular temperatures.

  16. Including Overweight or Obese Students in Physical Education: A Social Ecological Constraint Model

    Science.gov (United States)

    Li, Weidong; Rukavina, Paul

    2012-01-01

    In this review, we propose a social ecological constraint model to study inclusion of overweight or obese students in physical education by integrating key concepts and assumptions from ecological constraint theory in motor development and social ecological models in health promotion and behavior. The social ecological constraint model proposes…

  17. Between and beyond additivity and non-additivity; the statistical modelling of genotype by environment interaction in plant breeding.

    NARCIS (Netherlands)

    Eeuwijk, van F.A.

    1996-01-01

    In plant breeding it is a common observation to see genotypes react differently to environmental changes. This phenomenon is called genotype by environment interaction. Many statistical approaches for analysing genotype by environment interaction rely heavily on the analysis of variance model. Genot

  18. Between and beyond additivity and non-additivity : the statistical modelling of genotype by environment interaction in plant breeding

    NARCIS (Netherlands)

    Eeuwijk, van F.A.

    1996-01-01

    In plant breeding it is a common observation to see genotypes react differently to environmental changes. This phenomenon is called genotype by environment interaction. Many statistical approaches for analysing genotype by environment interaction rely heavily on the analysis of variance model.

  19. Adaptive fuzzy neural network control design via a T-S fuzzy model for a robot manipulator including actuator dynamics.

    Science.gov (United States)

    Wai, Rong-Jong; Yang, Zhi-Wei

    2008-10-01

    This paper focuses on the development of adaptive fuzzy neural network control (AFNNC), including indirect and direct frameworks for an n-link robot manipulator, to achieve high-precision position tracking. In general, it is difficult to adopt a model-based design to achieve this control objective due to the uncertainties in practical applications, such as friction forces, external disturbances, and parameter variations. In order to cope with this problem, an indirect AFNNC (IAFNNC) scheme and a direct AFNNC (DAFNNC) strategy are investigated without the requirement of prior system information. In these model-free control topologies, a continuous-time Takagi-Sugeno (T-S) dynamic fuzzy model with online learning ability is constructed to represent the system dynamics of an n-link robot manipulator. In the IAFNNC, an FNN estimator is designed to tune the nonlinear dynamic function vector in fuzzy local models, and then, the estimative vector is used to indirectly develop a stable IAFNNC law. In the DAFNNC, an FNN controller is directly designed to imitate a predetermined model-based stabilizing control law, and then, the stable control performance can be achieved by only using joint position information. All the IAFNNC and DAFNNC laws and the corresponding adaptive tuning algorithms for FNN weights are established in the sense of Lyapunov stability analyses to ensure the stable control performance. Numerical simulations and experimental results of a two-link robot manipulator actuated by dc servomotors are given to verify the effectiveness and robustness of the proposed methodologies. In addition, the superiority of the proposed control schemes is indicated in comparison with proportional-differential control, fuzzy-model-based control, T-S-type FNN control, and robust neural fuzzy network control systems.

  20. An estimating equation for parametric shared frailty models with marginal additive hazards

    DEFF Research Database (Denmark)

    Pipper, Christian Bressen; Martinussen, Torben

    2004-01-01

    Multivariate failure time data arise when data consist of clusters in which the failure times may be dependent. A popular approach to such data is the marginal proportional hazards model with estimation under the working independence assumption. In some contexts, however, it may be more reasonable...... to use the marginal additive hazards model. We derive asymptotic properties of the Lin and Ying estimators for the marginal additive hazards model for multivariate failure time data. Furthermore we suggest estimating equations for the regression parameters and association parameters in parametric shared...

  1. Modeling the significance of including C redistribution when determining changes in net carbon storage along a cultivated toposequence

    Science.gov (United States)

    Chirinda, Ngonidzashe; Olesen, Jørgen E.; Heckrath, Goswin; Paradelo Pérez, Marcos; Taghizadeh-Toosi, Arezoo

    2016-04-01

    Globally, soil carbon (C) reserves are second only to those in the ocean, and accounts for a significant C reservoir. In the case of arable soils, the quantity of stored C is influenced by various factors (e.g. management practices). Currently, the topography related influences on in-field soil C dynamics remain largely unknown. However, topography is known to influence a multiplicity of factors that regulate C input, storage and redistribution. To understand the patterns and untangle the complexity of soil C dynamics in arable landscapes, our study was conducted with soils from shoulderslope and footslope positions on a 7.1 ha winter wheat field in western Denmark. We first collected soil samples from shoulderslope and footslope positions with various depth intervals down to 100 cm and analyzed them for physical and chemical properties including texture and soil organic C contents. In-situ carbon dioxide (CO2) concentrations were measured at different soil profile depths at both positions for a year. Soil moisture content and temperature at 5 and 40 cm depth was measured continuously. Additionally, surface soil CO2 fluxes at shoulderslope and footslope positions were measured. We then used measurement data collected from the two landscape positions to calibrate the one-dimensional mechanistic model SOILCO2 module of the HYDRUS-1D software package and obtained soil CO2 fluxes from soil profile at two landscape positions. Furthermore, we tested whether the inclusion of vertical and lateral soil C movement improved the modeling of C dynamics in cultivated landscapes. For that, soil profile CO2 fluxes were compared with those obtained using a simple process-based soil whole profile C model, C-TOOL, which was modified to include vertical and lateral movement of C on landscape. Our results highlight the need to consider vertical and lateral soil C movement in the modeling of C dynamics in cultivated landscapes, for better qualification of net carbon storage.

  2. Incorporating shape constraints in generalized additive modelling of the height-diameter relationship for Norway spruce

    Directory of Open Access Journals (Sweden)

    Natalya Pya

    2016-02-01

    Full Text Available Background: Measurements of tree heights and diameters are essential in forest assessment and modelling. Tree heights are used for estimating timber volume, site index and other important variables related to forest growth and yield, succession and carbon budget models. However, the diameter at breast height (dbh can be more accurately obtained and at lower cost, than total tree height. Hence, generalized height-diameter (h-d models that predict tree height from dbh, age and other covariates are needed. For a more flexible but biologically plausible estimation of covariate effects we use shape constrained generalized additive models as an extension of existing h-d model approaches. We use causal site parameters such as index of aridity to enhance the generality and causality of the models and to enable predictions under projected changeable climatic conditions. Methods: We develop unconstrained generalized additive models (GAM and shape constrained generalized additive models (SCAM for investigating the possible effects of tree-specific parameters such as tree age, relative diameter at breast height, and site-specific parameters such as index of aridity and sum of daily mean temperature during vegetation period, on the h-d relationship of forests in Lower Saxony, Germany. Results: Some of the derived effects, e.g. effects of age, index of aridity and sum of daily mean temperature have significantly non-linear pattern. The need for using SCAM results from the fact that some of the model effects show partially implausible patterns especially at the boundaries of data ranges. The derived model predicts monotonically increasing levels of tree height with increasing age and temperature sum and decreasing aridity and social rank of a tree within a stand. The definition of constraints leads only to marginal or minor decline in the model statistics like AIC. An observed structured spatial trend in tree height is modelled via 2-dimensional surface

  3. Estimate of influenza cases using generalized linear, additive and mixed models.

    Science.gov (United States)

    Oviedo, Manuel; Domínguez, Ángela; Pilar Muñoz, M

    2015-01-01

    We investigated the relationship between reported cases of influenza in Catalonia (Spain). Covariates analyzed were: population, age, data of report of influenza, and health region during 2010-2014 using data obtained from the SISAP program (Institut Catala de la Salut - Generalitat of Catalonia). Reported cases were related with the study of covariates using a descriptive analysis. Generalized Linear Models, Generalized Additive Models and Generalized Additive Mixed Models were used to estimate the evolution of the transmission of influenza. Additive models can estimate non-linear effects of the covariates by smooth functions; and mixed models can estimate data dependence and variability in factor variables using correlations structures and random effects, respectively. The incidence rate of influenza was calculated as the incidence per 100 000 people. The mean rate was 13.75 (range 0-27.5) in the winter months (December, January, February) and 3.38 (range 0-12.57) in the remaining months. Statistical analysis showed that Generalized Additive Mixed Models were better adapted to the temporal evolution of influenza (serial correlation 0.59) than classical linear models.

  4. The selection and use of essential medicines. Report of the WHO expert committee, 2005 (including the 14th model list of essential medicines).

    Science.gov (United States)

    2006-01-01

    This report presents the recommendations of the WHO Expert Committee responsible for updating the WHO Model List of Essential Medicines. The first part contains a summary of the Committee's considerations and justifications for additions and changes to the Model List, including its recommendations. Annexes to the main report include the revised version of the WHO Model List of Essential Medicines (the 14th) and a list of all items on the Model List sorted according to their 5-level Anatomical Therapeutic Chemical (ATC) classification codes.

  5. Two methods for modeling vibrations of planetary gearboxes including faults: Comparison and validation

    Science.gov (United States)

    Parra, J.; Vicuña, Cristián Molina

    2017-08-01

    Planetary gearboxes are important components of many industrial applications. Vibration analysis can increase their lifetime and prevent expensive repair and safety concerns. However, an effective analysis is only possible if the vibration features of planetary gearboxes are properly understood. In this paper, models are used to study the frequency content of planetary gearbox vibrations under non-fault and different fault conditions. Two different models are considered: phenomenological model, which is an analytical-mathematical formulation based on observation, and lumped-parameter model, which is based on the solution of the equations of motion of the system. Results of both models are not directly comparable, because the phenomenological model provides the vibration on a fixed radial direction, such as the measurements of the vibration sensor mounted on the outer part of the ring gear. On the other hand, the lumped-parameter model provides the vibrations on the basis of a rotating reference frame fixed to the carrier. To overcome this situation, a function to decompose the lumped-parameter model solutions to a fixed reference frame is presented. Finally, comparisons of results from both model perspectives and experimental measurements are presented.

  6. GIS-based models for water quantity and quality assessment in the Júcar River Basin, Spain, including climate change effects.

    Science.gov (United States)

    Ferrer, Javier; Pérez-Martín, Miguel A; Jiménez, Sara; Estrela, Teodoro; Andreu, Joaquín

    2012-12-01

    This paper describes two different GIS models - one stationary (GeoImpress) and the other non-stationary (Patrical) - that assess water quantity and quality in the Júcar River Basin District, a large river basin district (43,000km(2)) located in Spain. It aims to analyze the status of surface water (SW) and groundwater (GW) bodies in relation to the European Water Framework Directive (WFD) and to support measures to achieve the WFD objectives. The non-stationary model is used for quantitative analysis of water resources, including long-term water resource assessment; estimation of available GW resources; and evaluation of climate change impact on water resources. The main results obtained are the following: recent water resources have been reduced by approximately 18% compared to the reference period 1961-1990; the GW environmental volume required to accomplish the WFD objectives is approximately 30% of the GW annual resources; and the climate change impact on water resources for the short-term (2010-2040), based on a dynamic downscaling A1B scenario, implies a reduction in water resources by approximately 19% compared to 1990-2000 and a reduction of approximately 40-50% for the long-term (2070-2100), based on dynamic downscaling A2 and B2 scenarios. The model also assesses the impact of various fertilizer application scenarios on the status of future GW quality (nitrate) and if these future statuses will meet the WFD requirements. The stationary model generates data on the actual and future chemical status of SW bodies in the river basin according to the modeled scenarios and reflects the implementation of different types of measures to accomplish the Urban Waste Water Treatment Directive and the WFD. Finally, the selection and prioritization of additional measures to accomplish the WFD are based on cost-effectiveness analysis.

  7. A two-dimensional simulation model of phosphorus uptake including crop growth and P-response

    NARCIS (Netherlands)

    Mollier, A.; Willigen, de P.; Heinen, M.; Morel, C.; Schneider, A.; Pellerin, S.

    2008-01-01

    Modelling nutrient uptake by crops implies considering and integrating the processes controlling the soil nutrient supply, the uptake by the root system and relationships between the crop growth response and the amount of nutrient absorbed. We developed a model that integrates both dynamics of maize

  8. European column buckling curves and finite element modelling including high strength steels

    DEFF Research Database (Denmark)

    Jönsson, Jeppe; Stan, Tudor-Cristian

    2017-01-01

    Eurocode allows for finite element modelling of plated steel structures, however the information in the code on how to perform the analysis or what assumptions to make is quite sparse. The present paper investigates the deterministic modelling of flexural column buckling using plane shell element...

  9. Dipole model analysis of highest precision HERA data, including very low $Q^2$'s

    CERN Document Server

    Luszczak, Agnieszka

    2016-01-01

    We analyse, within a dipole model, the final, inclusive HERA DIS cross section data in the low $x$ region, using fully correlated errors. We show, that these highest precision data are very well described within the dipole model framework starting from $Q^2$ values of 3.5 GeV$^2$ to the highest values of $Q^2 =$ 250 GeV$^2$.

  10. A Two-Account Life Insurance Model for Scenario-Based Valuation Including Event Risk

    DEFF Research Database (Denmark)

    Jensen, Ninna Reitzel; Schomacker, Kristian Juul

    2015-01-01

    and unit-linked insurance. By use of a two-account model, we are able to illustrate general concepts without making the model too abstract. To allow for complicated financial markets without dramatically increasing the mathematical complexity, we focus on economic scenarios. We illustrate the use of our......Using a two-account model with event risk, we model life insurance contracts taking into account both guaranteed and non-guaranteed payments in participating life insurance as well as in unit-linked insurance. Here, event risk is used as a generic term for life insurance events, such as death...... product types. This enables comparison of participating life insurance products and unit-linked insurance products, thus building a bridge between the two different ways of formalizing life insurance products. Finally, our model distinguishes itself from the existing literature by taking into account...

  11. Gasification of biomass in a fixed bed downdraft gasifier--a realistic model including tar.

    Science.gov (United States)

    Barman, Niladri Sekhar; Ghosh, Sudip; De, Sudipta

    2012-03-01

    This study presents a model for fixed bed downdraft biomass gasifiers considering tar also as one of the gasification products. A representative tar composition along with its mole fractions, as available in the literature was used as an input parameter within the model. The study used an equilibrium approach for the applicable gasification reactions and also considered possible deviations from equilibrium to further upgrade the equilibrium model to validate a range of reported experimental results. Heat balance was applied to predict the gasification temperature and the predicted values were compared with reported results in literature. A comparative study was made with some reference models available in the literature and also with experimental results reported in the literature. Finally a predicted variation of performance of the gasifier by this validated model for different air-fuel ratio and moisture content was also discussed.

  12. Including Tropical Croplands in a Terrestrial Biosphere Model: Application to West Africa

    Science.gov (United States)

    Berg, A.; Sultan, B.; de Noblet, N.

    2008-12-01

    Studying the large-scale relationships between climate and agriculture raises two different issues: the impact of climate on crops, and the potential feedbacks to climate from croplands. A relevant framework to consistently address this twofold issue is to extend existing Dynamic Global Vegetation Models, which can be coupled to climate models, in order to explicitly account for croplands. Here we present the first results of such a strategy applied to tropical croplands over West Africa. We introduce directly into the terrestrial biosphere model ORCHIDEE (IPSL) adequate processes and parametrizations taken from the crop model SARRAH (CIRAD), which is calibrated for millet over this region. The resulting model, ORCH-mil, realistically simulates the growth and yield of millet when tested on an experimental station in Senegal. The model is then applied over West Africa using a 36-year climate reanalysis dataset. First the model is tested in terms of yield simulation, against national millet yields from the FAO database. The ability of the model to reproduce the spatial and temporal variability of millet yields is assessed. Then, the effects on land surface fluxes of explicitly accounting for croplands are examined, by comparison between ORCH-mil and ORCHIDEE. These first simulations show consistent results, but underline the need for some further development and validation of the model if it is to simulate yields accurately. In terms of land surface fluxes, significant differences between ORCH-mil and ORCHIDEE appear, mainly via changes in evaporation and albedo. The potential impact on the west African monsoon system of such differences needs to be investigated by coupling ORCH-mil to a climate model: first results from such an experiment will be presented.

  13. Spatial modelling of marine organisms in Forsmark and Oskarshamn. Including calculation of physical predictor variables

    Energy Technology Data Exchange (ETDEWEB)

    Carlen, Ida; Nikolopoulos, Anna; Isaeus, Martin (AquaBiota Water Research, Stockholm (SE))

    2007-06-15

    GIS grids (maps) of marine parameters were created using point data from previous site investigations in the Forsmark and Oskarshamn areas. The proportion of global radiation reaching the sea bottom in Forsmark and Oskarshamn was calculated in ArcView, using Secchi depth measurements and the digital elevation models for the respective area. The number of days per year when the incoming light exceeds 5 MJ/m2 at the bottom was then calculated using the result of the previous calculations together with measured global radiation. Existing modelled grid-point data on bottom and pelagic temperature for Forsmark were interpolated to create surface covering grids. Bottom and pelagic temperature grids for Oskarshamn were calculated using point measurements to achieve yearly averages for a few points and then using regressions with existing grids to create new maps. Phytoplankton primary production in Forsmark was calculated using point measurements of chlorophyll and irradiance, and a regression with a modelled grid of Secchi depth. Distribution of biomass of macrophyte communities in Forsmark and Oskarshamn was calculated using spatial modelling in GRASP, based on field data from previous surveys. Physical parameters such as those described above were used as predictor variables. Distribution of biomass of different functional groups of fish in Forsmark was calculated using spatial modelling based on previous surveys and with predictor variables such as physical parameters and results from macrophyte modelling. All results are presented as maps in the report. The quality of the modelled predictions varies as a consequence of the quality and amount of the input data, the ecology and knowledge of the predicted phenomena, and by the modelling technique used. A substantial part of the variation is not described by the models, which should be expected for biological modelling. Therefore, the resulting grids should be used with caution and with this uncertainty kept in mind. All

  14. Simple vibration modeling of structural fuzzy with continuous boundary by including two-dimensional spatial memory

    DEFF Research Database (Denmark)

    Friis, Lars; Ohlrich, Mogens

    2008-01-01

    -dimensional continuous boundary. Additionally, a simple method for determining the so-called equivalent coupling factor is presented. The validity of this method is demonstrated by numerical simulations of the vibration response of a master plate structure with fuzzy attachments. It is revealed that the method performs...

  15. Structured Additive Regression Models: An R Interface to BayesX

    Directory of Open Access Journals (Sweden)

    Nikolaus Umlauf

    2015-02-01

    Full Text Available Structured additive regression (STAR models provide a flexible framework for model- ing possible nonlinear effects of covariates: They contain the well established frameworks of generalized linear models and generalized additive models as special cases but also allow a wider class of effects, e.g., for geographical or spatio-temporal data, allowing for specification of complex and realistic models. BayesX is standalone software package providing software for fitting general class of STAR models. Based on a comprehensive open-source regression toolbox written in C++, BayesX uses Bayesian inference for estimating STAR models based on Markov chain Monte Carlo simulation techniques, a mixed model representation of STAR models, or stepwise regression techniques combining penalized least squares estimation with model selection. BayesX not only covers models for responses from univariate exponential families, but also models from less-standard regression situations such as models for multi-categorical responses with either ordered or unordered categories, continuous time survival data, or continuous time multi-state models. This paper presents a new fully interactive R interface to BayesX: the R package R2BayesX. With the new package, STAR models can be conveniently specified using Rs formula language (with some extended terms, fitted using the BayesX binary, represented in R with objects of suitable classes, and finally printed/summarized/plotted. This makes BayesX much more accessible to users familiar with R and adds extensive graphics capabilities for visualizing fitted STAR models. Furthermore, R2BayesX complements the already impressive capabilities for semiparametric regression in R by a comprehensive toolbox comprising in particular more complex response types and alternative inferential procedures such as simulation-based Bayesian inference.

  16. Modeled hydraulic redistribution by Helianthus annuus L. matches observed data only after model modification to include nighttime transpiration

    Science.gov (United States)

    Neumann, R. B.; Cardon, Z. G.; Rockwell, F. E.; Teshera-Levye, J.; Zwieniecki, M.; Holbrook, N. M.

    2013-12-01

    The movement of water from moist to dry soil layers through the root systems of plants, referred to as hydraulic redistribution (HR), occurs throughout the world and is thought to influence carbon and water budgets and ecosystem functioning. The realized hydrologic, biogeochemical, and ecological consequences of HR depend on the amount of redistributed water, while the ability to assess these impacts requires models that correctly capture HR magnitude and timing. Using several soil types and two eco-types of Helianthus annuus L. in split-pot experiments, we examined how well the widely used HR modeling formulation developed by Ryel et al. (2002) could match experimental determination of HR across a range of water potential driving gradients. H. annuus carries out extensive nighttime transpiration, and though over the last decade it has become more widely recognized that nighttime transpiration occurs in multiple species and many ecosystems, the original Ryel et al. (2002) formulation does not include the effect of nighttime transpiration on HR. We developed and added a representation of nighttime transpiration into the formulation, and only then was the model able to capture the dynamics and magnitude of HR we observed as soils dried and nighttime stomatal behavior changed, both influencing HR.

  17. Simulated village locations in Thailand: A multi-scale model including a neural network approach.

    Science.gov (United States)

    Tang, Wenwu; Malanson, George P; Entwisle, Barbara

    2009-04-01

    The simulation of rural land use systems, in general, and rural settlement dynamics in particular has developed with synergies of theory and methods for decades. Three current issues are: linking spatial patterns and processes, representing hierarchical relations across scales, and considering nonlinearity to address complex non-stationary settlement dynamics. We present a hierarchical simulation model to investigate complex rural settlement dynamics in Nang Rong, Thailand. This simulation uses sub-models to allocate new villages at three spatial scales. Regional and sub-regional models, which involve a nonlinear space-time autoregressive model implemented in a neural network approach, determine the number of new villages to be established. A dynamic village niche model, establishing pattern-process link, was designed to enable the allocation of villages into specific locations. Spatiotemporal variability in model performance indicates the pattern of village location changes as a settlement frontier advances from rice-growing lowlands to higher elevations. Experiments results demonstrate this simulation model can enhance our understanding of settlement development in Nang Rong and thus gain insight into complex land use systems in this area.

  18. Potential transformation of trace species including aircraft exhaust in a cloud environment. The `Chedrom model`

    Energy Technology Data Exchange (ETDEWEB)

    Ozolin, Y.E.; Karol, I.L. [Main Geophysical Observatory, St. Petersburg (Russian Federation); Ramaroson, R. [Office National d`Etudes et de Recherches Aerospatiales (ONERA), 92 - Chatillon (France)

    1997-12-31

    Box model for coupled gaseous and aqueous phases is used for sensitivity study of potential transformation of trace gases in a cloud environment. The rate of this transformation decreases with decreasing of pH in droplets, with decreasing of photodissociation rates inside the cloud and with increasing of the droplet size. Model calculations show the potential formation of H{sub 2}O{sub 2} in aqueous phase and transformation of gaseous HNO{sub 3} into NO{sub x} in a cloud. This model is applied for exploration of aircraft exhausts evolution in plume inside a cloud. (author) 10 refs.

  19. A Two-Dimensional Modeling Procedure to Estimate the Loss Equivalent Resistance Including the Saturation Effect

    Directory of Open Access Journals (Sweden)

    Rosa Ana Salas

    2013-11-01

    Full Text Available We propose a modeling procedure specifically designed for a ferrite inductor excited by a waveform in time domain. We estimate the loss resistance in the core (parameter of the electrical model of the inductor by means of a Finite Element Method in 2D which leads to significant computational advantages over the 3D model. The methodology is validated for an RM (rectangular modulus ferrite core working in the linear and the saturation regions. Excellent agreement is found between the experimental data and the computational results.

  20. Recent Advances in Study on Thermodynamic Models for Real Systems Including Electrolytes

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    A comprehensive review of recent advances in study on thermodynamic models for real electrolyte solutions is presented. The differences between primitive and non-primitive electrolyte models are demonstrated. Some new thermodynamic models for electrolyte solutions based on the mean spherical approximation and perturbation theory are introduced. An extended scaled-particle theory and modified CleggPitz er equation are presented for physical and chemical absorption processes with mixed solvents, respectively. A pseudo one-component two-Yukawa equation of state is used for the aqueous two-phase extraction process in charged colloidal systems.

  1. Extension of Lithium Ion Cell Model to Include Transient and Low-Temperature Behaviour

    Science.gov (United States)

    Dudley, G.

    2014-08-01

    Current-interruption resistance measurements have been analysed in detail allowing the ESTEC lithium ion cell electrical/thermal model to be extended to allow modelling of cell voltage in response to imposed current changes at low temperatures and short time scales where activation polarisation becomes important. Whilst an unnecessary complication in most cases, this extension is needed under certain circumstances such as the simulation of Mars rover batteries forced to operate at low temperature and possible effects of battery voltage transients on battery-bus power subsystems. Comparison with test data show that the model is capable of giving a good fit in these circumstances.

  2. An accurate simulation model for single-photon avalanche diodes including important statistical effects

    Science.gov (United States)

    Qiuyang, He; Yue, Xu; Feifei, Zhao

    2013-10-01

    An accurate and complete circuit simulation model for single-photon avalanche diodes (SPADs) is presented. The derived model is not only able to simulate the static DC and dynamic AC behaviors of an SPAD operating in Geiger-mode, but also can emulate the second breakdown and the forward bias behaviors. In particular, it considers important statistical effects, such as dark-counting and after-pulsing phenomena. The developed model is implemented using the Verilog-A description language and can be directly performed in commercial simulators such as Cadence Spectre. The Spectre simulation results give a very good agreement with the experimental results reported in the open literature. This model shows a high simulation accuracy and very fast simulation rate.

  3. Extending the Scope of the Acculturation/Pidginization Model to Include Cognition.

    Science.gov (United States)

    Schumann, John H.

    1990-01-01

    Examines five cognitive models for second-language acquisition (SLA) and assesses how each might account for the Pidginized interlanguage found in the early stages of second-language acquisition. (23 references) (JL)

  4. A model for including Arduino microcontroller programming in the introductory physics lab

    CERN Document Server

    Haugen, Andrew J

    2014-01-01

    The paper describes a curricular framework for introducing microcontroller programming in the University Physics lab. The approach makes use of Modeling Instruction, an effective approach for teaching science at the secondary level in which student learn the standard material by developing and deploying models of the physical world. In our approach, students engage with a context-rich problem that can be solved with one or more sensors and a microcontroller. The solution path we describe then consists of developing a mathematical model for how the sensors' data can be mapped to a meaningful measurement, and further, developing an algorithmic model that will be implemented in the microcontroller. Once the system is developed and implemented, students are given an array of similar problems in which they can deploy their data collection system. Results from the implementation of this idea, in two University Physics sections, using Arduino microcontrollers, are also described.

  5. Global warming in a coupled climate model including oceanic eddy-induced advection

    Science.gov (United States)

    Hirst, Anthony C.; Gordon, Hal B.; O'Farrell, Siobhan P.

    The Gent and McWilliams (GM) parameterization for large-scale water transport caused by mesoscale oceanic eddies is introduced into the oceanic component of a global coupled ocean-atmosphere model. Parallel simulations with and without the GM scheme are performed to examine the effect of this parameterization on model behavior under constant atmospheric CO2 and on the model response to increasing CO2. The control (constant CO2) runs show substantial differences in the oceanic stratification and extent of convection, similar to differences found previously using uncoupled ocean models. The transient (increasing CO2) runs show moderate differences in the rate of oceanic heat sequestration (less in the GM case), as expected based on passive tracer uptake studies. However, the surface warming is weaker in the GM case, especially over the Southern Ocean, which is contrary to some recent supposition. Reasons for the reduced warming in the GM case are discussed.

  6. Empirical Validation of a Thermal Model of a Complex Roof Including Phase Change Materials

    CERN Document Server

    Guichard, Stéphane; Bigot, Dimitri; Malet-Damour, Bruno; Libelle, Teddy; Boyer, Harry

    2015-01-01

    This paper deals with the empirical validation of a building thermal model using a phase change material (PCM) in a complex roof. A mathematical model dedicated to phase change materials based on the heat apparent capacity method was implemented in a multi-zone building simulation code, the aim being to increase understanding of the thermal behavior of the whole building with PCM technologies. To empirically validate the model, the methodology is based both on numerical and experimental studies. A parametric sensitivity analysis was performed and a set of parameters of the thermal model have been identified for optimization. The use of a generic optimization program called GenOpt coupled to the building simulation code enabled to determine the set of adequate parameters. We first present the empirical validation methodology and main results of previous work. We then give an overview of GenOpt and its coupling with the building simulation code. Finally, once the optimization results are obtained, comparisons o...

  7. Including sugar cane in the agro-ecosystem model ORCHIDEE-STICS: calibration and validation

    Science.gov (United States)

    Valade, A.; Vuichard, N.; Ciais, P.; Viovy, N.

    2011-12-01

    Sugarcane is currently the most efficient bioenergy crop with regards to the energy produced per hectare. With approximately half the global bioethanol production in 2005, and a devoted land area expected to expand globally in the years to come, sugar cane is at the heart of the biofuel debate. Dynamic global vegetation models coupled with agronomical models are powerful and novel tools to tackle many of the environmental issues related to biofuels if they are carefully calibrated and validated against field observations. Here we adapt the agro-terrestrial model ORCHIDEE-STICS for sugar cane simulations. Observation data of LAI are used to evaluate the sensitivity of the model to parameters of nitrogen absorption and phenology, which are calibrated in a systematic way for six sites in Australia and La Reunion. We find that the optimal set of parameters is highly dependent on the sites' characteristics and that the model can reproduce satisfactorily the evolution of LAI. This careful calibration of ORCHIDEE-STICS for sugar cane biomass production for different locations and technical itineraries provides a strong basis for further analysis of the impacts of bioenergy-related land use change on carbon cycle budgets. As a next step, a sensitivity analysis is carried out to estimate the uncertainty of the model in biomass and carbon flux simulation due to its parameterization.

  8. A guide to generalized additive models in crop science using SAS and R

    Directory of Open Access Journals (Sweden)

    Josefine Liew

    2015-06-01

    Full Text Available Linear models and generalized linear models are well known and are used extensively in crop science. Generalized additive models (GAMs are less well known. GAMs extend generalized linear models through inclusion of smoothing functions of explanatory variables, e.g., spline functions, allowing the curves to bend to better describe the observed data. This article provides an introduction to GAMs in the context of crop science experiments. This is exemplified using a dataset consisting of four populations of perennial sow-thistle (Sonchus arvensis L., originating from two regions, for which emergence of shoots over time was compared.

  9. Large Eddy simulation of turbulence: A subgrid scale model including shear, vorticity, rotation, and buoyancy

    Science.gov (United States)

    Canuto, V. M.

    1994-01-01

    The Reynolds numbers that characterize geophysical and astrophysical turbulence (Re approximately equals 10(exp 8) for the planetary boundary layer and Re approximately equals 10(exp 14) for the Sun's interior) are too large to allow a direct numerical simulation (DNS) of the fundamental Navier-Stokes and temperature equations. In fact, the spatial number of grid points N approximately Re(exp 9/4) exceeds the computational capability of today's supercomputers. Alternative treatments are the ensemble-time average approach, and/or the volume average approach. Since the first method (Reynolds stress approach) is largely analytical, the resulting turbulence equations entail manageable computational requirements and can thus be linked to a stellar evolutionary code or, in the geophysical case, to general circulation models. In the volume average approach, one carries out a large eddy simulation (LES) which resolves numerically the largest scales, while the unresolved scales must be treated theoretically with a subgrid scale model (SGS). Contrary to the ensemble average approach, the LES+SGS approach has considerable computational requirements. Even if this prevents (for the time being) a LES+SGS model to be linked to stellar or geophysical codes, it is still of the greatest relevance as an 'experimental tool' to be used, inter alia, to improve the parameterizations needed in the ensemble average approach. Such a methodology has been successfully adopted in studies of the convective planetary boundary layer. Experienc e with the LES+SGS approach from different fields has shown that its reliability depends on the healthiness of the SGS model for numerical stability as well as for physical completeness. At present, the most widely used SGS model, the Smagorinsky model, accounts for the effect of the shear induced by the large resolved scales on the unresolved scales but does not account for the effects of buoyancy, anisotropy, rotation, and stable stratification. The

  10. Modal analysis of additive manufactured carbon fiber reinforced polymer composite framework: Experiment and modeling

    Science.gov (United States)

    Dryginin, N. V.; Krasnoveikin, V. A.; Filippov, A. V.; Tarasov, S. Yu.; Rubtsov, V. E.

    2016-11-01

    Additive manufacturing by 3D printing is the most advanced and promising trend for making the multicomponent composites. Polymer-based carbon fiber reinforced composites demonstrate high mechanical properties combined with low weight characteristics of the component. This paper shows the results of 3D modeling and experimental modal analysis on a polymer composite framework obtained using additive manufacturing. By the example of three oscillation modes it was shown the agreement between the results of modeling and experimental modal analysis with the use of laser Doppler vibrometry.

  11. Asymptotics on Semiparametric Analysis of Multivariate Failure Time Data Under the Additive Hazards Model

    Institute of Scientific and Technical Information of China (English)

    Huan-bin Liu; Liu-quan Sun; Li-xing Zhu

    2005-01-01

    Many survival studies record the times to two or more distinct failures on each subject. The failures may be events of different natures or may be repetitions of the same kind of event. In this article, we consider the regression analysis of such multivariate failure time data under the additive hazards model. Simple weighted estimating functions for the regression parameters are proposed, and asymptotic distribution theory of the resulting estimators are derived. In addition, a class of generalized Wald and generalized score statistics for hypothesis testing and model selection are presented, and the asymptotic properties of these statistics are examined.

  12. Influence of the heterogeneous reaction HCl + HOCl on an ozone hole model with hydrocarbon additions

    Science.gov (United States)

    Elliott, Scott; Cicerone, Ralph J.; Turco, Richard P.; Drdla, Katja; Tabazadeh, Azadeh

    1994-02-01

    Injection of ethane or propane has been suggested as a means for reducing ozone loss within the Antarctic vortex because alkanes can convert active chlorine radicals into hydrochloric acid. In kinetic models of vortex chemistry including as heterogeneous processes only the hydrolysis and HCl reactions of ClONO2 and N2O5, parts per billion by volume levels of the light alkanes counteract ozone depletion by sequestering chlorine atoms. Introduction of the surface reaction of HCl with HOCl causes ethane to deepen baseline ozone holes and generally works to impede any mitigation by hydrocarbons. The increased depletion occurs because HCl + HOCl can be driven by HOx radicals released during organic oxidation. Following initial hydrogen abstraction by chlorine, alkane breakdown leads to a net hydrochloric acid activation as the remaining hydrogen atoms enter the photochemical system. Lowering the rate constant for reactions of organic peroxy radicals with ClO to 10-13 cm3 molecule-1 s-1 does not alter results, and the major conclusions are insensitive to the timing of the ethane additions. Ignoring the organic peroxy radical plus ClO reactions entirely restores remediation capabilities by allowing HOx removal independent of HCl. Remediation also returns if early evaporation of polar stratospheric clouds leaves hydrogen atoms trapped in aldehyde intermediates, but real ozone losses are small in such cases.

  13. Discriminative accuracy of genomic profiling comparing multiplicative and additive risk models.

    Science.gov (United States)

    Moonesinghe, Ramal; Khoury, Muin J; Liu, Tiebin; Janssens, A Cecile J W

    2011-02-01

    Genetic prediction of common diseases is based on testing multiple genetic variants with weak effect sizes. Standard logistic regression and Cox Proportional Hazard models that assess the combined effect of multiple variants on disease risk assume multiplicative joint effects of the variants, but this assumption may not be correct. The risk model chosen may affect the predictive accuracy of genomic profiling. We investigated the discriminative accuracy of genomic profiling by comparing additive and multiplicative risk models. We examined genomic profiles of 40 variants with genotype frequencies varying from 0.1 to 0.4 and relative risks varying from 1.1 to 1.5 in separate scenarios assuming a disease risk of 10%. The discriminative accuracy was evaluated by the area under the receiver operating characteristic curve. Predicted risks were more extreme at the lower and higher risks for the multiplicative risk model compared with the additive model. The discriminative accuracy was consistently higher for multiplicative risk models than for additive risk models. The differences in discriminative accuracy were negligible when the effect sizes were small (risk genotypes were common or when they had stronger effects. Unraveling the exact mode of biological interaction is important when effect sizes of genetic variants are moderate at the least, to prevent the incorrect estimation of risks.

  14. Including the effects of debris cover in a distributed glacier energy balance model (Invited)

    Science.gov (United States)

    Pellicciotti, F.; Reid, T.; Carenzo, M.; Brock, B. W.

    2010-12-01

    Distributed models of glacier energy balance, which make use of digital elevation models and extensive spatial data on local meteorology, have become very useful tools for predicting glacial ablation and runoff in recent years. They generally function by running a one-dimensional energy balance model at every point on a grid on the glacier surface - for each point in the grid the ablation is calculated based on the balance of heat fluxes at the ice-air boundary. However, one key component has been missing from distributed models to date, namely the effects of debris cover. Many glacier ablation zones are mantled in near-continuous blankets of rock debris, and debris-covered glaciers are important drivers of the water cycle in the European Alps, Andes and Himalayas. Moreover, debris covers have been seen to expand in recent years, so it is essential to assess exactly how the presence of debris may affect a glacier’s surface energy balance and potential responses to climate changes. The effects of a debris cover are complicated by the varying surface roughness, albedo and thermal properties of the debris in question, but generally a debris cover reduces glacier melt rate by insulating the glacier surface from direct solar radiation. Even on glaciers where the debris cover is not continuous, isolated patches of debris caused by rockfalls can affect the glacier evolution by introducing differential ablation across the glacier surface, thus creating ice-cored moraines that may persist after ‘clean’ parts of the glacier have wasted away. This paper presents the results of incorporating a one-dimensional ‘debris energy balance model’ called DEB-Model (Reid and Brock 2010) into a distributed melt model for Haut Glacier d’Arolla, Switzerland. DEB-Model numerically estimates debris surface temperature by considering the balance of heat fluxes at the air-debris interface, then calculates heat conduction through the debris in order to estimate melt rates at the

  15. GLOBAL APPROACH OF CHANNEL MODELING IN MOBILE AD HOC NETWORKS INCLUDING SECOND ORDER STATISTICS AND SYSTEM PERFORMANCES ANALYSIS

    Directory of Open Access Journals (Sweden)

    Basile L. AGBA

    2008-06-01

    Full Text Available Mobile ad hoc networks (MANET are very difficult to design in terms of scenarios specification and propagation modeling. All these aspects must be taken into account when designing MANET. For cost-effective designing, powerful and accurate simulation tools are needed. Our first contribution in this paper is to provide a global approach process (GAP in channel modeling combining scenarios and propagation in order to have a better analysis of the physical layer, and finally to improve performances of the whole network. The GAP is implemented in an integrated simulation tool, Ad-SMPro. Moreover, channel statistics, throughput and delay are some key points to be considered when studying a mobile wireless networks. A carefully analysis of mobility effects over second order channel statistics and system performances is made based on our optimized simulation tool, Ad-SMProl. The channel is modeled by large scale fading and small scale fading including Doppler spectrum due to the double mobility of the nodes. Level Cross Rate and Average Duration of Fade are simulated as function of double mobility degree, a defined to be the ratio of the nodes' speeds. These results are compared to the theoretical predictions. We demonstrate that, in mobile ad hoc networks, flat fading channels and frequency-selective fading channels are differently affected. In addition, Bit Error rate is analysed as function of the ratio of the average bit energy to thermal noise density. Other performances (such as throughput, delay and routing traffic are analysed and conclusions related to the proposed simulation model and the mobility effects are drawn.

  16. High resolution multi model Climate change scenario over India including first uncertainty assessment

    Science.gov (United States)

    Kumar, P.; Wiltshire, A.; Asharaf, S.; Ahrens, B.; Lucas-Picher, P.; Christensen, J. H.; Gobiet, A.; Saeed, F.; Hagemann, S.; Jacob, D.

    2011-12-01

    This study presents the possible regional climate change over SA with a focus over India as simulated by three very-high-resolution regional climate models. The models are driven by the same lateral boundary conditions from two global models (ECHAM5-MPIOM and HadCM3) under the IPCC AR4 SRES A1B scenario at horizontal resolution of ~25km, except one model which is simulated for only one GCM. The results are presented for two time slices 2021-2050 and 2070-2099. The analysis concentrates along precipitation and temperature over land and focuses mainly on the monsoon season. The circulation parameter is also discussed. In general all models show a clear signal of gradual wide-spread warming throughout the 21st century. The ensemble-mean warming evident at the end of 2050 is 1-2K, whereas it is 3-5K at the end of century. The projected pattern of the precipitation change shows spatial variability. The increase in precipitation is noticed over peninsular and coastal areas and no change or decrease over areas away from the ocean. The influence of the driving GCM on projected precipitation change simulated with each RCM is as strong as the variability among the RCMs driven with one GCM. Some results of the first uncertainties assessment are also presented.

  17. HIV model parameter estimates from interruption trial data including drug efficacy and reservoir dynamics.

    Directory of Open Access Journals (Sweden)

    Rutao Luo

    Full Text Available Mathematical models based on ordinary differential equations (ODE have had significant impact on understanding HIV disease dynamics and optimizing patient treatment. A model that characterizes the essential disease dynamics can be used for prediction only if the model parameters are identifiable from clinical data. Most previous parameter identification studies for HIV have used sparsely sampled data from the decay phase following the introduction of therapy. In this paper, model parameters are identified from frequently sampled viral-load data taken from ten patients enrolled in the previously published AutoVac HAART interruption study, providing between 69 and 114 viral load measurements from 3-5 phases of viral decay and rebound for each patient. This dataset is considerably larger than those used in previously published parameter estimation studies. Furthermore, the measurements come from two separate experimental conditions, which allows for the direct estimation of drug efficacy and reservoir contribution rates, two parameters that cannot be identified from decay-phase data alone. A Markov-Chain Monte-Carlo method is used to estimate the model parameter values, with initial estimates obtained using nonlinear least-squares methods. The posterior distributions of the parameter estimates are reported and compared for all patients.

  18. Integrated reservoir characterization: Improvement in heterogeneities stochastic modelling by integration of additional external constraints

    Energy Technology Data Exchange (ETDEWEB)

    Doligez, B.; Eschard, R. [Institut Francais du Petrole, Rueil Malmaison (France); Geffroy, F. [Centre de Geostatistique, Fontainebleau (France)] [and others

    1997-08-01

    The classical approach to construct reservoir models is to start with a fine scale geological model which is informed with petrophysical properties. Then scaling-up techniques allow to obtain a reservoir model which is compatible with the fluid flow simulators. Geostatistical modelling techniques are widely used to build the geological models before scaling-up. These methods provide equiprobable images of the area under investigation, which honor the well data, and which variability is the same than the variability computed from the data. At an appraisal phase, when few data are available, or when the wells are insufficient to describe all the heterogeneities and the behavior of the field, additional constraints are needed to obtain a more realistic geological model. For example, seismic data or stratigraphic models can provide average reservoir information with an excellent areal coverage, but with a poor vertical resolution. New advances in modelisation techniques allow now to integrate this type of additional external information in order to constrain the simulations. In particular, 2D or 3D seismic derived information grids, or sand-shale ratios maps coming from stratigraphic models can be used as external drifts to compute the geological image of the reservoir at the fine scale. Examples are presented to illustrate the use of these new tools, their impact on the final reservoir model, and their sensitivity to some key parameters.

  19. Assessment of Chinese sturgeon habitat suitability in the Yangtze River (China): Comparison of generalized additive model, data-driven fuzzy logic model, and preference curve model

    Science.gov (United States)

    Yi, Yujun; Sun, Jie; Zhang, Shanghong; Yang, Zhifeng

    2016-05-01

    To date, a wide range of models have been applied to evaluate aquatic habitat suitability. In this study, three models, including the expert knowledge-based preference curve model (PCM), data-driven fuzzy logic model (DDFL), and generalized additive model (GAM), are used on a common data set to compare their effectiveness and accuracy. The true skill statistic (TSS) and the area under the receiver operating characteristics curve (AUC) are used to evaluate the accuracy of the three models. The results indicate that the two data-based methods (DDFL and GAM) yield better accuracy than the expert knowledge-based PCM, and the GAM yields the best accuracy. There are minor differences in the suitable ranges of the physical habitat variables obtained from the three models. The hydraulic habitat suitability index (HHSI) calculated by the PCM is the largest, followed by the DDFL and then the GAM. The results illustrate that data-based models can describe habitat suitability more objectively and accurately when there are sufficient data. When field data are lacking, combining expertise with data-based models is recommended. When field data are difficult to obtain, an expert knowledge-based model can be used as a replacement for the data-based methods.

  20. Complete Loss and Thermal Model of Power Semiconductors Including Device Rating Information

    DEFF Research Database (Denmark)

    Ma, Ke; Bahman, Amir Sajjad; Beczkowski, Szymon;

    2015-01-01

    loading but also the device rating as input variables. The quantified correlation between the power loss, thermal impedance and silicon area of Insulated Gate Bipolar Transistor (IGBT) is mathematically established. By this new modeling approach, all factors that have impacts to the loss and thermal......Thermal loading of power devices are closely related to the reliability performance of the whole converter system. The electrical loading and device rating are both important factors that determine the loss and thermal behaviors of power semiconductor devices. In the existing loss and thermal...... models, only the electrical loadings are focused and treated as design variables, while the device rating is normally pre-defined by experience with limited design flexibility. Consequently, a more complete loss and thermal model is proposed in this paper, which takes into account not only the electrical...

  1. A Simple Model of Fields Including the Strong or Nuclear Force and a Cosmological Speculation

    Directory of Open Access Journals (Sweden)

    David L. Spencer

    2016-10-01

    Full Text Available Reexamining the assumptions underlying the General Theory of Relativity and calling an object's gravitational field its inertia, and acceleration simply resistance to that inertia, yields a simple field model where the potential (kinetic energy of a particle at rest is its capacity to move itself when its inertial field becomes imbalanced. The model then attributes electromagnetic and strong forces to the effects of changes in basic particle shape. Following up on the model's assumption that the relative intensity of a particle's gravitational field is always inversely related to its perceived volume and assuming that all black holes spin, may create the possibility of a cosmic rebound where a final spinning black hole ends with a new Big Bang.

  2. Numerical models of single- and double-negative metamaterials including viscous and thermal losses

    DEFF Research Database (Denmark)

    Cutanda Henriquez, Vicente; Sánchez-Dehesa, José

    2017-01-01

    Negative index acoustic metamaterials are artificial structures made of subwavelength units arranged in a lattice, whose effective acoustic parameters, bulk modulus and mass density, can be negative. In these materials, sound waves propagate inside the periodic structure, assumed rigid, showing...... extraordinary properties. We are interested in two particular cases: a double-negative metamaterial, where both parameters are negative at some frequencies, and a single-negative metamaterial with negative bulk modulus within a broader frequency band. In previous research involving the double......-negative metamaterial, numerical models with viscous and thermal losses were used to explain that the extraordinary behavior, predicted by analytical models and numerical simulations with no losses, disappeared when the metamaterial was measured in physical setups. The improvement of the models is allowing now a more...

  3. Damped structural dynamics models of large wind-turbine blades including material and structural damping

    Energy Technology Data Exchange (ETDEWEB)

    Chortis, D I; Chrysochoidis, N A; Saravanos, D A [Department of Mechanical Engineering and Aeronautics, University of Patras, Patras 26500 (Greece)

    2007-07-15

    The paper presents a brief description of composite damping mechanics for blade sections of arbitrary lamination and geometry. A damped 3-D shear beam element is presented enabling the assembly of damped structural dynamic models of blades with hollow multi-cell tubular laminated sections. Emphasis is placed to the inclusion of composite material coupling effects, first in the blade section stiffness and damping matrices and finally into the stiffness and damping matrices of the finite element. Evaluations of the beam element are presented, to quantify the material coupling effect on composite beams of simple box sections. Correlations between predicted and measured modal frequencies and damping values in small model Glass/Epoxy are also shown. Finally, the damped modal characteristics of a 35m realistic wind-turbine blade model design, are predicted.

  4. A study of a hamiltonian model for martensitic phase transformations including microkinetic energy

    CERN Document Server

    Theil, F

    1998-01-01

    How can a system in a macroscopically stable state explore energetically more favorable states, which are far away from the current equilibrium state? Based on continuum mechanical considerations we derive a Boussinesq-type equation which models the dynamics of martensitic phase transformations. The solutions of the system, which we refer to as microkinetically regularized wave equation exhibit strong oscillations after short times, thermalization can be confirmed. That means that macroscopic fluctuations of the solutions decay at the benefit of microscopic fluctuations. First analytical and numerical results on the propagation of phase boundaries and thermalization effects are presented. Despite the fact that model is conservative, it exhibits the hysteretic behavior. Such a behavior is usually interpreted in macroscopic models in terms of dissipative threshold which the driving force has to overcome to ensure that the phase transformation proceeds. The threshold value depends on the amount of the transforme...

  5. Loss and thermal model for power semiconductors including device rating information

    DEFF Research Database (Denmark)

    Ma, Ke; Bahman, Amir Sajjad; Beczkowski, Szymon;

    2014-01-01

    The electrical loading and device rating are both important factors that determine the loss and thermal behaviors of power semiconductor devices. In the existing loss and thermal models, only the electrical loadings are focused and treated as design variables, while the device rating is normally...... pre-defined by experience with poor design flexibility. Consequently a more complete loss and thermal model is proposed in this paper, which takes into account not only the electrical loading but also the device rating as input variables. The quantified correlation between the power loss, thermal...... impedance and silicon area of Insulated Gate Bipolar Transistor (IGBT) is mathematically established. By this new modeling approach, all factors that have impacts to the loss and thermal profiles of power devices can be accurately mapped, enabling more design freedom to optimize the efficiency and thermal...

  6. Complete Loss and Thermal Model of Power Semiconductors Including Device Rating Information

    DEFF Research Database (Denmark)

    Ma, Ke; Bahman, Amir Sajjad; Beczkowski, Szymon

    2015-01-01

    profiles of the power devices can accurately be mapped, enabling more design freedom to optimize the efficiency and thermal loading of the power converter. The proposed model can be further improved by experimental tests, and it is well agreed by both circuit and Finite Element Method (FEM) simulation......Thermal loading of power devices are closely related to the reliability performance of the whole converter system. The electrical loading and device rating are both important factors that determine the loss and thermal behaviors of power semiconductor devices. In the existing loss and thermal...... models, only the electrical loadings are focused and treated as design variables, while the device rating is normally pre-defined by experience with limited design flexibility. Consequently, a more complete loss and thermal model is proposed in this paper, which takes into account not only the electrical...

  7. Loss and thermal model for power semiconductors including device rating information

    DEFF Research Database (Denmark)

    Ma, Ke; Bahman, Amir Sajjad; Beczkowski, Szymon

    2014-01-01

    impedance and silicon area of Insulated Gate Bipolar Transistor (IGBT) is mathematically established. By this new modeling approach, all factors that have impacts to the loss and thermal profiles of power devices can be accurately mapped, enabling more design freedom to optimize the efficiency and thermal......The electrical loading and device rating are both important factors that determine the loss and thermal behaviors of power semiconductor devices. In the existing loss and thermal models, only the electrical loadings are focused and treated as design variables, while the device rating is normally...... pre-defined by experience with poor design flexibility. Consequently a more complete loss and thermal model is proposed in this paper, which takes into account not only the electrical loading but also the device rating as input variables. The quantified correlation between the power loss, thermal...

  8. New results in RR Lyrae modeling: convective cycles, additional modes and more

    CERN Document Server

    Molnár, L; Szabó, R; Plachy, E

    2012-01-01

    Recent theoretical and observational findings breathed new life into the field of RR Lyrae stars. The ever more precise and complete measurements of the space asteroseismology missions revealed new details, such as the period doubling and the presence of the additional modes in the stars. Theoretical work also flourished: period doubling was explained and an additional mode has been detected in hydrodynamic models as well. Although the most intriguing mystery, the Blazhko-effect has remained unsolved, new findings indicate that the convective cycle model can be effectively ruled out for short- and medium-period modulations. On the other hand, the plausibility of the radial resonance model is increasing, as more and more resonances are detected both in models and stars.

  9. Analysis of error-prone survival data under additive hazards models: measurement error effects and adjustments.

    Science.gov (United States)

    Yan, Ying; Yi, Grace Y

    2016-07-01

    Covariate measurement error occurs commonly in survival analysis. Under the proportional hazards model, measurement error effects have been well studied, and various inference methods have been developed to correct for error effects under such a model. In contrast, error-contaminated survival data under the additive hazards model have received relatively less attention. In this paper, we investigate this problem by exploring measurement error effects on parameter estimation and the change of the hazard function. New insights of measurement error effects are revealed, as opposed to well-documented results for the Cox proportional hazards model. We propose a class of bias correction estimators that embraces certain existing estimators as special cases. In addition, we exploit the regression calibration method to reduce measurement error effects. Theoretical results for the developed methods are established, and numerical assessments are conducted to illustrate the finite sample performance of our methods.

  10. [download] (1035Coordinate Descent Methods for the Penalized Semiparametric Additive Hazards Model

    Directory of Open Access Journals (Sweden)

    Anders Gorst-Rasmussen

    2012-04-01

    Full Text Available For survival data with a large number of explanatory variables, lasso penalized Cox regression is a popular regularization strategy. However, a penalized Cox model may not always provide the best fit to data and can be difficult to estimate in high dimension because of its intrinsic nonlinearity. The semiparametric additive hazards model is a flexible alternative which is a natural survival analogue of the standard linear regression model. Building on this analogy, we develop a cyclic coordinate descent algorithm for fitting the lasso and elastic net penalized additive hazards model. The algorithm requires no nonlinear optimization steps and offers excellent performance and stability. An implementation is available in the R package ahaz. We demonstrate this implementation in a small timing study and in an application to real data.

  11. Nonparametric Independence Screening in Sparse Ultra-High Dimensional Additive Models

    CERN Document Server

    Fan, Jianqing; Song, Rui

    2011-01-01

    A variable screening procedure via correlation learning was proposed Fan and Lv (2008) to reduce dimensionality in sparse ultra-high dimensional models. Even when the true model is linear, the marginal regression can be highly nonlinear. To address this issue, we further extend the correlation learning to marginal nonparametric learning. Our nonparametric independence screening is called NIS, a specific member of the sure independence screening. Several closely related variable screening procedures are proposed. Under the nonparametric additive models, it is shown that under some mild technical conditions, the proposed independence screening methods enjoy a sure screening property. The extent to which the dimensionality can be reduced by independence screening is also explicitly quantified. As a methodological extension, an iterative nonparametric independence screening (INIS) is also proposed to enhance the finite sample performance for fitting sparse additive models. The simulation results and a real data a...

  12. A biomechanical model of the face including muscles for the prediction of deformations during speech production

    CERN Document Server

    Groleau, Julie; Marecaux, Christophe; Payrard, Natacha; Segaud, Brice; Rochette, Michel; Perrier, Pascal; Payan, Yohan

    2008-01-01

    A 3D biomechanical finite element model of the face is presented. Muscles are represented by piece-wise uniaxial tension cable elements linking the insertion points. Such insertion points are specific entities differing from nodes of the finite element mesh, which makes possible to change either the mesh or the muscle implementation totally independently of each other. Lip/teeth and upper lip/lower lip contacts are also modeled. Simulations of smiling and of an Orbicularis Oris activation are presented and interpreted. The importance of a proper account of contacts and of an accurate anatomical description is shown

  13. European air quality modelled by CAMx including the volatility basis set scheme

    Directory of Open Access Journals (Sweden)

    G. Ciarelli

    2015-12-01

    Full Text Available Four periods of EMEP (European Monitoring and Evaluation Programme intensive measurement campaigns (June 2006, January 2007, September–October 2008 and February–March 2009 were modelled using the regional air quality model CAMx with VBS (Volatility Basis Set approach for the first time in Europe within the framework of the EURODELTA-III model intercomparison exercise. More detailed analysis and sensitivity tests were performed for the period of February–March 2009 and June 2006 to investigate the uncertainties in emissions as well as to improve the modelling of organic aerosols (OA. Model performance for selected gas phase species and PM2.5 was evaluated using the European air quality database Airbase. Sulfur dioxide (SO2 and ozone (O3 were found to be overestimated for all the four periods with O3 having the largest mean bias during June 2006 and January–February 2007 periods (8.93 and 12.30 ppb mean biases, respectively. In contrast, nitrogen dioxide (NO2 and carbon monoxide (CO were found to be underestimated for all the four periods. CAMx reproduced both total concentrations and monthly variations of PM2.5 very well for all the four periods with average biases ranging from −2.13 to 1.04 μg m-3. Comparisons with AMS (Aerosol Mass Spectrometer measurements at different sites in Europe during February–March 2009, showed that in general the model over-predicts the inorganic aerosol fraction and under-predicts the organic one, such that the good agreement for PM2.5 is partly due to compensation of errors. The effect of the choice of volatility basis set scheme (VBS on OA was investigated as well. Two sensitivity tests with volatility distributions based on previous chamber and ambient measurements data were performed. For February–March 2009 the chamber-case reduced the total OA concentrations by about 43 % on average. On the other hand, a test based on ambient measurement data increased OA concentrations by about 47 % for the same

  14. Viscoelastic Model of Cross-Linked Polyethylene Including Effects of Temperature and Crystallinity

    Science.gov (United States)

    Olasz, L.; Gudmundson, P.

    2005-12-01

    Characterization of the mechanical behavior of cross-linked polyethylene (XLPE) commonly used in high voltage cable insulation was performed by an extensive set of isothermal uniaxial tensile relaxation tests. Tensile relaxation experiments were complemented by pressure-volume-temperature experiments as well as density and crystallinity measurements. Based on the experimental results, a viscoelastic power law model with four parameters was formulated, incorporating temperature and crystallinity dependence. It was found that a master curve can be developed by both horizontal and vertical shifting of the relaxation curves. The model was evaluated by making comparisons of the predicted stress responses with the measured responses in relaxation tests with transient temperature histories.

  15.  The additive hazards model with high-dimensional regressors

    DEFF Research Database (Denmark)

    Martinussen, Torben

    2009-01-01

    This paper considers estimation and prediction in the Aalen additive hazards model in the case where the covariate vector is high-dimensional such as gene expression measurements. Some form of dimension reduction of the covariate space is needed to obtain useful statistical analyses. We study the...... model. A standard PLS algorithm can also be constructed, but it turns out that the resulting predictor can only be related to the original covariates via time-dependent coefficients...

  16. Situational effects of the school factors included in the dynamic model of educational effectiveness

    NARCIS (Netherlands)

    Creerners, Bert; Kyriakides, Leonidas

    2009-01-01

    We present results of a longitudinal study in which 50 schools, 113 classes and 2,542 Cypriot primary students participated. We tested the validity of the dynamic model of educational effectiveness and especially its assumption that the impact of school factors depends on the current situation of th

  17. Turbulent combustion modelling of a confined premixed jet flame including heat loss effects using tabulated chemistry

    NARCIS (Netherlands)

    Gövert, S.; Mira, D.; Kok, J.B.W.; Vázquez, M.; Houzeaux, G.

    2015-01-01

    The present work addresses the coupling of a flamelet database, to a low-Mach approximation of the Navier–Stokes equations using scalar controlling variables. The model is characterized by the chemistry tabulation based on laminar premixed flamelets in combination with an optimal choice of the react

  18. New phases in an extended Hubbard model explicitly including atomic polarizabilities

    NARCIS (Netherlands)

    Brink, van de J.; Meinders, M.B.J.; Lorenzana, J.; Eder, R.; Sawatzky, G.A.

    1996-01-01

    We consider the influence of a nearest-neighbor Coulomb interaction in an extended Hubbard model and introduce a new interaction term which simulates atomic polarizabilities. This has the effect of screening the on-site Coulomb interaction for charged excitations, unlike a neighbor Coulomb interacti

  19. Modeling of etch profile evolution including wafer charging effects using self consistent ion fluxes

    Energy Technology Data Exchange (ETDEWEB)

    Hoekstra, R.J.; Kushner, M.J. [Univ. of Illinois, Urbana, IL (United States). Dept. of Electrical and Computer Engineering

    1996-12-31

    As high density plasma reactors become more predominate in industry, the need has intensified for computer aided design tools which address both equipment issues such as ion flux uniformity onto the water and process issues such etch feature profile evolution. A hierarchy of models has been developed to address these issues with the goal of producing a comprehensive plasma processing design capability. The Hybrid Plasma Equipment Model (HPEM) produces ion and neutral densities, and electric fields in the reactor. The Plasma Chemistry Monte Carlo Model (PCMC) determines the angular and energy distributions of ion and neutral fluxes to the wafer using species source functions, time dependent bulk electric fields, and sheath potentials from the HPEM. These fluxes are then used by the Monte Carlo Feature Profile Model (MCFP) to determine the time evolution of etch feature profiles. Using this hierarchy, the effects of physical modifications of the reactor, such as changing wafer clamps or electrode structures, on etch profiles can be evaluated. The effects of wafer charging on feature evolution are examined by calculating the fields produced by the charge deposited by ions and electrons within the features. The effect of radial variations and nonuniformity in angular and energy distribution of the reactive fluxes on feature profiles and feature charging will be discussed for p-Si etching in inductively-coupled plasma (ICP) sustained in chlorine gas mixtures. The effects of over- and under-wafer topography on etch profiles will also be discussed.

  20. Surface-wave mode coupling : modelling and inverting waveforms including body-wave phases

    NARCIS (Netherlands)

    Marquering, H.A.

    1996-01-01

    This thesis is concerned with a similar problem as addressed by Li & Tanimoto (1993) in the surfacewave mode approach. In this thesis it is shown that surface-wave mode coupling is required when body-wave phases in laterally heterogeneous media are modelled by surface-wave mode summation. An efficie

  1. Analytical and numerical modelling of thermoviscous shocks in their interactions in nonlinear fluids including dissipation

    DEFF Research Database (Denmark)

    Rasmussen, Anders Rønne; Sørensen, Mads Peter; Gaididei, Yuri Borisovich

    2010-01-01

    A wave equation, that governs finite amplitude acoustic disturbances in a thermoviscous Newtonian fluid, and includes nonlinear terms up to second order, is proposed. The equation preserves the Hamiltonian structure of the fundamental fluid dynamical equations in the non dissipative limit. An exact...

  2. Changing dynamics: Time-varying autoregressive models using generalized additive modeling.

    Science.gov (United States)

    Bringmann, Laura F; Hamaker, Ellen L; Vigo, Daniel E; Aubert, André; Borsboom, Denny; Tuerlinckx, Francis

    2017-09-01

    In psychology, the use of intensive longitudinal data has steeply increased during the past decade. As a result, studying temporal dependencies in such data with autoregressive modeling is becoming common practice. However, standard autoregressive models are often suboptimal as they assume that parameters are time-invariant. This is problematic if changing dynamics (e.g., changes in the temporal dependency of a process) govern the time series. Often a change in the process, such as emotional well-being during therapy, is the very reason why it is interesting and important to study psychological dynamics. As a result, there is a need for an easily applicable method for studying such nonstationary processes that result from changing dynamics. In this article we present such a tool: the semiparametric TV-AR model. We show with a simulation study and an empirical application that the TV-AR model can approximate nonstationary processes well if there are at least 100 time points available and no unknown abrupt changes in the data. Notably, no prior knowledge of the processes that drive change in the dynamic structure is necessary. We conclude that the TV-AR model has significant potential for studying changing dynamics in psychology. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  3. Representational Flexibility and Problem-Solving Ability in Fraction and Decimal Number Addition: A Structural Model

    Science.gov (United States)

    Deliyianni, Eleni; Gagatsis, Athanasios; Elia, Iliada; Panaoura, Areti

    2016-01-01

    The aim of this study was to propose and validate a structural model in fraction and decimal number addition, which is founded primarily on a synthesis of major theoretical approaches in the field of representations in Mathematics and also on previous research on the learning of fractions and decimals. The study was conducted among 1,701 primary…

  4. Modeling the use of sulfate additives for potassium chloride destruction in biomass combustion

    DEFF Research Database (Denmark)

    Wu, Hao; Grell, Morten Nedergaard; Jespersen, Jacob Boll;

    2013-01-01

    was affected by the decomposition temperature. Based on the experimental data, a model was proposed to simulate the sulfation of KCl by different sulfate addition, and the simulation results were compared with pilot-scale experiments conducted in a bubbling fluidized bed reactor. The simulation results...

  5. Parametrically Guided Generalized Additive Models with Application to Mergers and Acquisitions Data.

    Science.gov (United States)

    Fan, Jianqing; Maity, Arnab; Wang, Yihui; Wu, Yichao

    2013-01-01

    Generalized nonparametric additive models present a flexible way to evaluate the effects of several covariates on a general outcome of interest via a link function. In this modeling framework, one assumes that the effect of each of the covariates is nonparametric and additive. However, in practice, often there is prior information available about the shape of the regression functions, possibly from pilot studies or exploratory analysis. In this paper, we consider such situations and propose an estimation procedure where the prior information is used as a parametric guide to fit the additive model. Specifically, we first posit a parametric family for each of the regression functions using the prior information (parametric guides). After removing these parametric trends, we then estimate the remainder of the nonparametric functions using a nonparametric generalized additive model, and form the final estimates by adding back the parametric trend. We investigate the asymptotic properties of the estimates and show that when a good guide is chosen, the asymptotic variance of the estimates can be reduced significantly while keeping the asymptotic variance same as the unguided estimator. We observe the performance of our method via a simulation study and demonstrate our method by applying to a real data set on mergers and acquisitions.

  6. Representational Flexibility and Problem-Solving Ability in Fraction and Decimal Number Addition: A Structural Model

    Science.gov (United States)

    Deliyianni, Eleni; Gagatsis, Athanasios; Elia, Iliada; Panaoura, Areti

    2016-01-01

    The aim of this study was to propose and validate a structural model in fraction and decimal number addition, which is founded primarily on a synthesis of major theoretical approaches in the field of representations in Mathematics and also on previous research on the learning of fractions and decimals. The study was conducted among 1,701 primary…

  7. Midrapidity inclusive densities in high energy pp collisions in additive quark model

    Science.gov (United States)

    Shabelski, Yu. M.; Shuvaev, A. G.

    2016-08-01

    High energy (CERN SPS and LHC) inelastic pp (pbar{p}) scattering is treated in the framework of the additive quark model together with Pomeron exchange theory. We extract the midrapidity inclusive density of the charged secondaries produced in a single quark-quark collision and investigate its energy dependence. Predictions for the π p collisions are presented.

  8. Roughing It Up: Including Jump Components in the Measurement, Modeling and Forecasting of Return Volatility

    DEFF Research Database (Denmark)

    Bollerslev, Tim; Andersen, Torben G.; Diebold, Francis X.

    A rapidly growing literature has documented important improvements in financial return volatility measurement and forecasting via use of realized variation measures constructed from high-frequency returns coupled with simple modeling procedures. Building on recent theoretical results in Barndorff...... bond yield, we find that jumps are both highly prevalent and distinctly less persistent than the continuous sample path variation process. Moreover, many jumps appear directly associated with specific macroeconomic news announcements. Separating jump from non-jump movements in a simple...... but sophisticated volatility forecasting model, we find that almost all of the predictability in daily, weekly, and monthly return volatilities comes from the non-jump component. Our results thus set the stage for a number of interesting future econometric developments and important financial applications...

  9. Mathematical analysis of a two-dimensional population model of metastatic growth including angiogenesis

    CERN Document Server

    Benzekry, Sebastien

    2010-01-01

    Angiogenesis is a key process in the tumoral growth which allows the cancerous tissue to impact on its vasculature in order to improve the nutrient's supply and the metastatic process. In this paper, we introduce a model for the density of metastasis which takes into account for this feature. It is a two dimensional structured equation with a vanishing velocity field and a source term on the boundary. We present here the mathematical analysis of the model, namely the well-posedness of the equation and the asymptotic behavior of the solutions, whose natural regularity led us to investigate some basic properties of the space $\\Wd(\\Om)=\\{V\\in L^1;\\;\\div(GV)\\in L^1\\}$, where $G$ is the velocity field of the equation.

  10. Roughing It Up: Including Jump Components in the Measurement, Modeling and Forecasting of Return Volatility

    DEFF Research Database (Denmark)

    Bollerslev, Tim; Andersen, Torben G.; Diebold, Francis X.

    -Nielsen and Shephard (2004a, 2005) for related bi-power variation measures, the present paper provides a practical and robust framework for non-parametrically measuring the jump component in asset return volatility. In an application to the DM/$ exchange rate, the S&P500 market index, and the 30-year U.S. Treasury......A rapidly growing literature has documented important improvements in financial return volatility measurement and forecasting via use of realized variation measures constructed from high-frequency returns coupled with simple modeling procedures. Building on recent theoretical results in Barndorff...... but sophisticated volatility forecasting model, we find that almost all of the predictability in daily, weekly, and monthly return volatilities comes from the non-jump component. Our results thus set the stage for a number of interesting future econometric developments and important financial applications...

  11. Micromagnetic model for studies on Magnetic Tunnel Junction switching dynamics, including local current density

    Energy Technology Data Exchange (ETDEWEB)

    Frankowski, Marek, E-mail: mfrankow@agh.edu.pl; Czapkiewicz, Maciej; Skowronski, Witold; Stobiecki, Tomasz

    2014-02-15

    We present a model introducing the Landau–Lifshitz–Gilbert equation with a Slonczewski's Spin-Transfer-Torque (STT) component in order to take into account spin polarized current influence on the magnetization dynamics, which was developed as an Object Oriented MicroMagnetic Framework extension. We implement the following computations: magnetoresistance of vertical channels is calculated from the local spin arrangement, local current density is used to calculate the in-plane and perpendicular STT components as well as the Oersted field, which is caused by the vertical current flow. The model allows for an analysis of all listed components separately, therefore, the contribution of each physical phenomenon in dynamic behavior of Magnetic Tunnel Junction (MTJ) magnetization is discussed. The simulated switching voltage is compared with the experimental data measured in MTJ nanopillars.

  12. Solution model of nonlinear integral adjustment including different kinds of observing data with different precisions

    Institute of Scientific and Technical Information of China (English)

    郭金运; 陶华学

    2003-01-01

    In order to process different kinds of observing data with different precisions, a new solution model of nonlinear dynamic integral least squares adjustment was put forward, which is not dependent on their derivatives. The partial derivative of each component in the target function is not computed while iteratively solving the problem. Especially when the nonlinear target function is more complex and very difficult to solve the problem, the method can greatly reduce the computing load.

  13. A Multiscale Progressive Failure Modeling Methodology for Composites that Includes Fiber Strength Stochastics

    Science.gov (United States)

    Ricks, Trenton M.; Lacy, Thomas E., Jr.; Bednarcyk, Brett A.; Arnold, Steven M.; Hutchins, John W.

    2014-01-01

    A multiscale modeling methodology was developed for continuous fiber composites that incorporates a statistical distribution of fiber strengths into coupled multiscale micromechanics/finite element (FE) analyses. A modified two-parameter Weibull cumulative distribution function, which accounts for the effect of fiber length on the probability of failure, was used to characterize the statistical distribution of fiber strengths. A parametric study using the NASA Micromechanics Analysis Code with the Generalized Method of Cells (MAC/GMC) was performed to assess the effect of variable fiber strengths on local composite failure within a repeating unit cell (RUC) and subsequent global failure. The NASA code FEAMAC and the ABAQUS finite element solver were used to analyze the progressive failure of a unidirectional SCS-6/TIMETAL 21S metal matrix composite tensile dogbone specimen at 650 degC. Multiscale progressive failure analyses were performed to quantify the effect of spatially varying fiber strengths on the RUC-averaged and global stress-strain responses and failure. The ultimate composite strengths and distribution of failure locations (predominately within the gage section) reasonably matched the experimentally observed failure behavior. The predicted composite failure behavior suggests that use of macroscale models that exploit global geometric symmetries are inappropriate for cases where the actual distribution of local fiber strengths displays no such symmetries. This issue has not received much attention in the literature. Moreover, the model discretization at a specific length scale can have a profound effect on the computational costs associated with multiscale simulations.models that yield accurate yet tractable results.

  14. A quark model calculation of yy->pipi including final-state interactions

    CERN Document Server

    Blundell, H G; Hay, G; Swanso, E

    2000-01-01

    A quark model calculation of the processes yy->pi+pi- and yy->pipi is performed. At tree level, only charged pions couple to the initial state photons and neutral pions are not exceeded in the final state. However a small but significant cross section is observed. We demonstrate that this may be accounted for by a rotation in isospin space induced by final-state interactions.

  15. Paint Pavement Marking Performance Prediction Model That Includes the Impacts of Snow Removal Operations

    Science.gov (United States)

    2011-03-01

    Hypothesized that snow plows wear down mountain road pavement markings. 2007 Craig et al. -Edge lines degrade slower than center/skip lines 2007...retroreflectivity to create the models. They discovered that paint pavement markings last 80% longer on Portland Cement Concrete than Asphalt Concrete at low AADT...retroreflectivity, while yellow markings lost 21%. Lu and Barter attributed the sizable degradation to snow removal, sand application, and studded

  16. Molten pool-lower head integrity. Heat transfer models including advanced numerical simulations (DNS)

    Energy Technology Data Exchange (ETDEWEB)

    Seiler, J.M.; Bonnet, J.M.; Bernaz, L. [CEA Grenoble (France)

    2001-07-01

    Extensive studies have been performed to investigate the heat transfer within a molten corium pool (homogeneous, stratified and with miscibility gap): Synthesis of heat transfer correlations in molten pool (homogeneous and stratified), Focusing effect in stratified metal layer, DNS analysis of Rayleigh Benard instabilities at the top boundary; interpretation of the different convection regimes and exponents affecting the Rayleigh number in the heat transfer correlations, Molten pool model for corium presenting a miscibility gap. Condition for de-stratification. (authors)

  17. Modeling the Corona and Solar Wind using ADAPT Maps that Include Far-Side Observations

    Science.gov (United States)

    2013-11-01

    document for any purpose other than Government procurement does not in any way obligate the U.S. Government. The fact that the Government formulated...Government’s approval or disapproval of its ideas or findings. Approved for public release; distribution is unlimited. REPORT DOCUMENTATION PAGE...Los Alamos National Laboratory ( LANL ) and the National Solar Observatory (NSO), has developed a model that produces more realistic estimates of the

  18. Numerical modelling of the transport of trace gases including methane in the subsurface of Mars

    Science.gov (United States)

    Stevens, Adam H.; Patel, Manish R.; Lewis, Stephen R.

    2015-04-01

    We model the transport of gas through the martian subsurface in order to quantify the timescales of release of a trace gas with a source at depth using a Fickian model of diffusion through a putative martian regolith column. The model is then applied to the case of methane to determine if diffusive transport of gas can explain previous observations of methane in the martian atmosphere. We investigate which parameters in the model have the greatest effect on transport timescales and show that the calculated diffusivity is very sensitive to the pressure profile of the subsurface, but relatively insensitive to the temperature profile, though diffusive transport may be affected by other temperature dependent properties of the subsurface such as the local vapour pressure. Uncertainties in the structure and physical conditions of the martian subsurface also introduce uncertainties in the timescales calculated. It was found that methane may take several hundred thousand Mars-years to diffuse from a source at depth. Purely diffusive transport cannot explain transient release that varies on timescales of less than one martian year from sources such as serpentinization or methanogenic organisms at depths of more than 2 km. However, diffusion of gas released by the destabilisation of methane clathrate hydrates close to the surface, for example caused by transient mass wasting events or erosion, could produce a rapidly varying flux of methane into the atmosphere of more than 10-3 kg m-2 s-1 over a duration of less than half a martian year, consistent with observations of martian methane variability. Seismic events, magmatic intrusions or impacts could also potentially produce similar patterns of release, but are far more complex to simulate.

  19. Numerical modeling of shallow flows including bottom topography and friction effects

    OpenAIRE

    Lukácová-Medvid'ová, Maria

    2004-01-01

    The aim of the paper is numerical modeling of the shallow water equation with source terms by genuinely multdimensional finite volume evolution Galerkin schemes. The shallow water system, or its one-dimensional analogy the Saint-Venant equation, is used extensively for numerical simulation of natural rivers. Mathematically the shallow water system belongs to the class of balance laws. A special treatment of the source terms describing the bottom topography as well as frictions effects is nece...

  20. Climate change impact modelling needs to include cross-sectoral interactions

    Science.gov (United States)

    Harrison, Paula A.; Dunford, Robert W.; Holman, Ian P.; Rounsevell, Mark D. A.

    2016-09-01

    Climate change impact assessments often apply models of individual sectors such as agriculture, forestry and water use without considering interactions between these sectors. This is likely to lead to misrepresentation of impacts, and consequently to poor decisions about climate adaptation. However, no published research assesses the differences between impacts simulated by single-sector and integrated models. Here we compare 14 indicators derived from a set of impact models run within single-sector and integrated frameworks across a range of climate and socio-economic scenarios in Europe. We show that single-sector studies misrepresent the spatial pattern, direction and magnitude of most impacts because they omit the complex interdependencies within human and environmental systems. The discrepancies are particularly pronounced for indicators such as food production and water exploitation, which are highly influenced by other sectors through changes in demand, land suitability and resource competition. Furthermore, the discrepancies are greater under different socio-economic scenarios than different climate scenarios, and at the sub-regional rather than Europe-wide scale.

  1. Kinetic model of water disinfection using peracetic acid including synergistic effects.

    Science.gov (United States)

    Flores, Marina J; Brandi, Rodolfo J; Cassano, Alberto E; Labas, Marisol D

    2016-01-01

    The disinfection efficiencies of a commercial mixture of peracetic acid against Escherichia coli were studied in laboratory scale experiments. The joint and separate action of two disinfectant agents, hydrogen peroxide and peracetic acid, were evaluated in order to observe synergistic effects. A kinetic model for each component of the mixture and for the commercial mixture was proposed. Through simple mathematical equations, the model describes different stages of attack by disinfectants during the inactivation process. Based on the experiments and the kinetic parameters obtained, it could be established that the efficiency of hydrogen peroxide was much lower than that of peracetic acid alone. However, the contribution of hydrogen peroxide was very important in the commercial mixture. It should be noted that this improvement occurred only after peracetic acid had initiated the attack on the cell. This synergistic effect was successfully explained by the proposed scheme and was verified by experimental results. Besides providing a clearer mechanistic understanding of water disinfection, such models may improve our ability to design reactors.

  2. Including A-Priori Assessment of Actual Evapotranspiration for Green Roof Daily Scale Hydrological Modelling

    Directory of Open Access Journals (Sweden)

    Mirka Mobilia

    2017-01-01

    Full Text Available In the last decades, there has been a widespread implementation of Green Infrastructures worldwide. Among these, green roofs appear to be particularly flexible sustainable drainage facilities. To predict their effectiveness for planning purposes, a tool is required that provides information as a function of local meteorological variables. Thus, a relatively simple daily scale, one-dimensional water balance approach has been proposed. The crucial evapotranspiration process, usually considered as a water balance dependent variable, is replaced here by empirical relationships providing an a-priori assessment of soil water losses through actual evapotranspiration. The modelling scheme, which under some simplification can be used without a calibration process, has been applied to experimental runoff data monitored at a green roof located near Bernkastel (Germany, between April 2005 and December 2006. Two different empirical relationships have been used to model actual evapotranspiration, considering a water availability limited and an energy limited scheme. Model errors quantification, ranging from 2% to 40% on the long-term scale and from 1% to 36% at the event scale, appear strongly related to the particularly considered relationship.

  3. Modelling topical photodynamic therapy treatment including the continuous production of Protoporphyrin IX

    Science.gov (United States)

    Campbell, C. L.; Brown, C. T. A.; Wood, K.; Moseley, H.

    2016-11-01

    Most existing theoretical models of photodynamic therapy (PDT) assume a uniform initial distribution of the photosensitive molecule, Protoporphyrin IX (PpIX). This is an adequate assumption when the prodrug is systematically administered; however for topical PDT this is no longer a valid assumption. Topical application and subsequent diffusion of the prodrug results in an inhomogeneous distribution of PpIX, especially after short incubation times, prior to light illumination. In this work a theoretical simulation of PDT where the PpIX distribution depends on the incubation time and the treatment modality is described. Three steps of the PpIX production are considered. The first is the distribution of the topically applied prodrug, the second in the conversion from the prodrug to PpIX and the third is the light distribution which affects the PpIX distribution through photobleaching. The light distribution is modelled using a Monte Carlo radiation transfer model and indicates treatment depths of around 2 mm during daylight PDT and approximately 3 mm during conventional PDT. The results suggest that treatment depths are not only limited by the light penetration but also by the PpIX distribution.

  4. A stepped leader model for lightning including charge distribution in branched channels

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Wei; Zhang, Li [School of Electrical Engineering, Shandong University, Jinan 250061 (China); Li, Qingmin, E-mail: lqmeee@ncepu.edu.cn [Beijing Key Lab of HV and EMC, North China Electric Power University, Beijing 102206 (China); State Key Lab of Alternate Electrical Power System with Renewable Energy Sources, Beijing 102206 (China)

    2014-09-14

    The stepped leader process in negative cloud-to-ground lightning plays a vital role in lightning protection analysis. As lightning discharge usually presents significant branched or tortuous channels, the charge distribution along the branched channels and the stochastic feature of stepped leader propagation were investigated in this paper. The charge density along the leader channel and the charge in the leader tip for each lightning branch were approximated by introducing branch correlation coefficients. In combination with geometric characteristics of natural lightning discharge, a stochastic stepped leader propagation model was presented based on the fractal theory. By comparing simulation results with the statistics of natural lightning discharges, it was found that the fractal dimension of lightning trajectory in simulation was in the range of that observed in nature and the calculation results of electric field at ground level were in good agreement with the measurements of a negative flash, which shows the validity of this proposed model. Furthermore, a new equation to estimate the lightning striking distance to flat ground was suggested based on the present model. The striking distance obtained by this new equation is smaller than the value estimated by previous equations, which indicates that the traditional equations may somewhat overestimate the attractive effect of the ground.

  5. Numerical Modeling of the Surface Fatigue Crack Propagation Including the Closure Effect

    Science.gov (United States)

    Guchinsky, Ruslan; Petinov, Sergei

    2016-01-01

    Presently modeling of surface fatigue crack growth for residual life assessment of structural elements is almost entirely based on application of the Linear Elastic Fracture Mechanics (LEFM). Generally, it is assumed that the crack front does not essentially change its shape, although it is not always confirmed by experiment. Furthermore, LEFM approach cannot be applied when the stress singularity vanishes due to material plasticity, one of the leading factors associated with the material degradation and fracture. Also, evaluation of stress intensity factors meets difficulties associated with changes in the stress state along the crack front circumference. An approach proposed for simulation the evolution of surface cracks based on application of the Strain-life criterion for fatigue failure and of the finite element modeling of damage accumulation. It takes into account the crack closure effect, the nonlinear behavior of damage accumulation and material compliance increasing due to the damage advance. The damage accumulation technique was applied to model the semi-elliptical crack growth from the initial defect in the steel compact specimen. The results of simulation are in good agreement with the published experimental data.

  6. Developing parameters for multi-mode ambient air models including the nanometer mode

    Science.gov (United States)

    Tronville, Paolo; Rivers, Richard

    2017-06-01

    The particle count, surface and mass in an occupied space can be modeled when the HVAC system airflows are known, along with the particle-size distribution for outdoor air, internal generation rates as a function of particle size, and the efficiency as a function of particle size for filters present. Outdoor air particle-size distribution is rarely available, but measures of particle mass concentration, PM2.5 and PM10, are often available for building locations. Outdoor air aerosol size distributions are well modeled by sums of two or three log-normal distributions, with essentially all mass in two larger modes. Studies have also shown that some mode parameters are, in general, related by simple functions. This paper shows how these relationships can be combined with known characteristics of PM2.5 and PM10 samplers to create reasonable inclusive models of outdoor air aerosol-size distributions. This information plus knowledge of indoor particle generation allows calculation of aerosol mass in occupied spaces. Estimation of parameters of aerosol modes with sizes below100 nm and measurement of filter efficiencies in that range are described.

  7. Galactic habitable zone around M and FGK stars with chemical evolution models that include dust

    Science.gov (United States)

    Spitoni, E.; Gioannini, L.; Matteucci, F.

    2017-09-01

    Context. The Galactic habitable zone is defined as the region with a metallicity that is high enough to form planetary systems in which Earth-like planets could be born and might be capable of sustaining life. Life in this zone needs to survive the destructive effects of nearby supernova explosion events. Aims: Galactic chemical evolution models can be useful tools for studying the galactic habitable zones in different systems. Our aim here is to find the Galactic habitable zone using chemical evolution models for the Milky Way disk, adopting the most recent prescriptions for the evolution of dust and for the probability of finding planetary systems around M and FGK stars. Moreover, for the first time, we express these probabilities in terms of the dust-to-gas ratio of the interstellar medium in the solar neighborhood as computed by detailed chemical evolution models. Methods: At a fixed Galactic time and Galactocentric distance, we determined the number of M and FGK stars that host earths (but no gas giant planets) that survived supernova explosions, using the formalism of our Paper I. Results: The probabilities of finding terrestrial planets but not gas giant planets around M stars deviate substantially from the probabilities around FGK stars for supersolar values of [Fe/H]. For both FGK and M stars, the maximum number of stars hosting habitable planets is at 8 kpc from the Galactic Center when destructive effects by supernova explosions are taken into account. Currently, M stars with habitable planets are ≃10 times more frequent than FGK stars. Moreover, we provide a sixth-order polynomial fit (and a linear fit, but that is more approximated) for the relation found with chemical evolution models in the solar neighborhood between the [Fe/H] abundances and the dust-to-gas ratio. Conclusions: The most likely Galactic zone in which to find terrestrial habitable planets around M and FGK stars is the annular 2 kpc wide region that is centered at 8 kpc from the

  8. Comparison of lead isotopes with source apportionment models, including SOM, for air particulates.

    Science.gov (United States)

    Gulson, Brian; Korsch, Michael; Dickson, Bruce; Cohen, David; Mizon, Karen; Davis, J Michael

    2007-08-01

    We have measured high precision lead isotopes in PM(2.5) particulates from a highly-trafficked site (Mascot) and rural site (Richmond) in the Sydney Basin, New South Wales, Australia to compare with isotopic data from total suspended particulates (TSP) from other sites in the Sydney Basin and evaluate relationships with source fingerprints obtained from multi-element PM(2.5) data. The isotopic data for the period 1998 to 2004 show seasonal peaks and troughs that are more pronounced in the rural site for the PM(2.5).samples but are consistent with the TSP. The Self Organising Map (SOM) method has been applied to the multi-element PM(2.5) data to evaluate its use in obtaining fingerprints for comparison with standard statistical procedures (ANSTO model). As seasonal effects are also significant for the multi-element data, the SOM modelling is reported as site and season dependent. At the Mascot site, the ANSTO model exhibits decreasing (206)Pb/(204)Pb ratios with increasing contributions of fingerprints for "secondary smoke" (industry), "soil", "smoke" and "seaspray". Similar patterns were shown by SOM winter fingerprints for both sites. At the rural site, there are large isotopic variations but for the majority of samples these are not associated with increased contributions from the main sources with the ANSTO model. For two winter sampling times, there are increased contributions from "secondary industry", "smoke", "soil" and seaspray with one time having a source or sources of Pb similar to that of Mascot. The only positive relationship between increasing (206)Pb/(204)Pb ratio and source contributions is found at the rural site using the SOM summer fingerprints, both of which show a significant contribution from sulphur. Several of the fingerprints using either model have significant contributions from black carbon (BC) and/or sulphur (S) that probably derive from diesel fuels and industrial sources. Increased contributions from sources with the SOM summer

  9. Model of Organic Solar Cell Photocurrent Including the Effect of Charge Accumulation at Interfaces and Non-Uniform Carrier Generation

    DEFF Research Database (Denmark)

    Torto, Lorenzo; Cester, Andrea; Rizzo, Antonio

    2017-01-01

    We developed an improved model to fit the photocurrent density versus voltage in organic solar cells. The model has been validated by fitting data from P3HT:PCBM solar cells. Our model quantitatively accounts for the band bending near the electrodes caused by charge accumulation in the active layer....... The model explains the position of the built-in and the zero-field voltage, the value of the internal electric field, the impact of electrode materials, and the appearance of multiple inflections. In addition, the model can be used to monitor the cell condition during accelerated lifetests....

  10. Modeling Longitudinal Data with Generalized Additive Models: Applications to Single-Case Designs

    Science.gov (United States)

    Sullivan, Kristynn J.; Shadish, William R.

    2013-01-01

    Single case designs (SCDs) are short time series that assess intervention effects by measuring units repeatedly over time both in the presence and absence of treatment. For a variety of reasons, interest in the statistical analysis and meta-analysis of these designs has been growing in recent years. This paper proposes modeling SCD data with…

  11. Recent Additions in the Modeling Capabilities of an Open-Source Wave Energy Converter Design Tool: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Tom, N.; Lawson, M.; Yu, Y. H.

    2015-04-20

    WEC-Sim is a midfidelity numerical tool for modeling wave energy conversion devices. The code uses the MATLAB SimMechanics package to solve multibody dynamics and models wave interactions using hydrodynamic coefficients derived from frequency-domain boundary-element methods. This paper presents the new modeling features introduced in the latest release of WEC-Sim. The first feature discussed conversion of the fluid memory kernel to a state-space form. This enhancement offers a substantial computational benefit after the hydrodynamic body-to-body coefficients are introduced and the number of interactions increases exponentially with each additional body. Additional features include the ability to calculate the wave-excitation forces based on the instantaneous incident wave angle, allowing the device to weathervane, as well as import a user-defined wave elevation time series. A review of the hydrodynamic theory for each feature is provided and the successful implementation is verified using test cases.

  12. Able but unintelligent: including positively stereotyped black subgroups in the stereotype content model.

    Science.gov (United States)

    Walzer, Amy S; Czopp, Alexander M

    2011-01-01

    The stereotype content model (SCM) posits that warmth and competence are the key components underlying judgments about social groups. Because competence can encompass different components (e.g., intelligence, talent) different group members may be perceived to be competent for different reasons. Therefore, we believe it may be important to specify the type of competence being assessed when examining perceptions of groups that are positively stereotyped (i.e., Black athletes and musical Blacks). Consistent with the SCM, these subgroups were perceived as high in competence-talent but not in competence-intelligence and low in warmth. Both the intelligence and talent frame of competence fit in the SCM's social structural hypothesis.

  13. Microregion model of a contact line including evaporation, kinetics and slip

    Science.gov (United States)

    Anderson, Daniel; Janecek, Vladislav

    2016-11-01

    We consider the evaporation of a liquid on a uniformly heated solid substrate. In the framework of lubrication theory we consider hydrodynamics, heat conduction, phase change, evaporation kinetics, and slip. Our model focuses only on the contact line 'inner' region which allows us to quantify the impact of evaporation on the apparent contact angle and microregion heat transfer. The linearized problem with respect to the substrate overheating is solved analytically. The analytical solutions are compared with full numerical solutions and to predictions of Hocking.

  14. Mathematical modeling of the hypothalamic–pituitary–adrenal gland (HPA) axis, including hippocampal mechanisms

    DEFF Research Database (Denmark)

    Andersen, Morten; Vinther, Frank; Ottesen, Johnny T.

    2013-01-01

    non-negative and bounded, which can be interpreted as a mathematical formulation of homeostasis. No oscillating solutions are present when using physiologically reasonable parameter values. This indicates that the ultradian rhythm originate from different mechanisms.Using physiologically reasonable......This paper presents a mathematical model of the HPA axis. The HPA axis consists of the hypothalamus, the pituitary and the adrenal glands in which the three hormones CRH, ACTH and cortisol interact through receptor dynamics. Furthermore, it has been suggested that receptors in the hippocampus have...

  15. Nuclear monopole charge form factor calculation for relativistic models including center-of-mass corrections

    Energy Technology Data Exchange (ETDEWEB)

    Avancini, S.S.; Marinelli, J.R. [Universidade Federal de Santa Catarina Florianopolis, Depto de Fisica - CFM, Florianopolis (Brazil); Carlson, B.V. [Instituto Tecnologico de Aeronautica, Sao Jose dos Campos (Brazil)

    2013-06-15

    Relativistic models for finite nuclei contain spurious center-of-mass motion in most applications for the nuclear many-body problem, where the nuclear wave function is taken as a single Slater determinant within a space-fixed frame description. We use the Peierls-Yoccoz projection method, previously developed for relativistic approaches together with a reparametrization of the coupling constants that fits binding energies and charge radius and apply our results to calculate elastic electron scattering monopole charge form factors for light nuclei. (orig.)

  16. Double pendulum model for a tennis stroke including a collision process

    Science.gov (United States)

    Youn, Sun-Hyun

    2015-10-01

    By means of adding a collision process between the ball and racket in the double pendulum model, we analyzed the tennis stroke. The ball and the racket system may be accelerated during the collision time; thus, the speed of the rebound ball does not simply depend on the angular velocity of the racket. A higher angular velocity sometimes gives a lower rebound ball speed. We numerically showed that the proper time-lagged racket rotation increased the speed of the rebound ball by 20%. We also showed that the elbow should move in the proper direction in order to add the angular velocity of the racket.

  17. Modeling the elastic behavior of ductile cast iron including anisotropy in the graphite nodules

    DEFF Research Database (Denmark)

    Andriollo, Tito; Thorborg, Jesper; Hattel, Jesper Henri

    2016-01-01

    This paper presents a micro-mechanical approach to model the intrinsic elastic anisotropy of the graphite particles in ductile iron. Contrary to most of the published works in the field, the constitutive behavior is directly derived on the basis of the nodule characteristic internal structure......, composed of graphite platelets arranged into conical sectors. In this way, the large uncertainty traditionally associated with local mechanical measurements of micro-hardness is eliminated. The proposed anisotropic description is validated by simulating the macroscopic ductile iron elastic response...

  18. NB-PLC channel modelling with cyclostationary noise addition & OFDM implementation for smart grid

    Science.gov (United States)

    Thomas, Togis; Gupta, K. K.

    2016-03-01

    Power line communication (PLC) technology can be a viable solution for the future ubiquitous networks because it provides a cheaper alternative to other wired technology currently being used for communication. In smart grid Power Line Communication (PLC) is used to support communication with low rate on low voltage (LV) distribution network. In this paper, we propose the channel modelling of narrowband (NB) PLC in the frequency range 5 KHz to 500 KHz by using ABCD parameter with cyclostationary noise addition. Behaviour of the channel was studied by the addition of 11KV/230V transformer, by varying load location and load. Bit error rate (BER) Vs signal to noise ratio SNR) was plotted for the proposed model by employing OFDM. Our simulation results based on the proposed channel model show an acceptable performance in terms of bit error rate versus signal to noise ratio, which enables communication required for smart grid applications.

  19. Including Antenna Models in Microwave Imaging for Breast-Cancer Screening

    DEFF Research Database (Denmark)

    Rubæk, Tonny; Meincke, Peter

    2006-01-01

    Microwave imaging is emerging as a tool for screening for breast cancer, but the lack of methods for including the characteristics of the antennas of the imaging systems in the imaging algorithms limits their performance. In this paper, a method for incorporating the full antenna characteristics......, in terms of the transmission-matrix representation, in a frequency-domain imaging algorithm is presented. The algorithm is tested on a simulation of the Physical-Anomaly Tomography (PAT) scanner imaging system developed at the Technical University of Denmark and is shown to have superior performance when...

  20. Pancreatic Response to Gold Nanoparticles Includes Decrease of Oxidative Stress and Inflammation In Autistic Diabetic Model

    Directory of Open Access Journals (Sweden)

    Manar E. Selim

    2015-01-01

    Full Text Available Background: Gold nanoparticles (AuNPs have a wide range of applications in various fields. This study provides an understanding of the modulatory effects of AuNPs on an antioxidant system in male Wistar diabetic rats with autism spectrum disorder (ASD. Normal littermates fed by control mothers were injected with citrate buffer alone and served as normal, untreated controls controlin this study. Diabetes mellitus (DM was induced by administering a single intraperitoneal injection of streptozotocin (STZ (100 mg/kg to the pups of (ND diabetic group, which had been fasted overnight. Autistic pups from mothers that had received a single intraperitoneal injection of 600 mg/kg sodium valproate on day 12.5 after conception were randomly divided into 2 groups (n 2 7/group as follow; administering single intraperitoneal injection of streptozotocin (STZ ( (100 mg/kg to the overnight fasted autistic pups of (AD autistic diabetic group. The treatment was started on the 5th day after STZ injection with the same dose as in group II and it was considered as 1st day of treatment with gold nanoparticles for 7 days to each rat of (group IV treated autistic diabetic group(TAD at a dosage of 2.5 mg/kg. b. wt. Results: At this dose of administration AuNPs, the activities of hepatic superoxide dismutase (SOD, glutathione peroxidase (GPx, and catalase were greater in group TAD compared with the control group (P 0.05 in the liver of autistic diabetic AuNPs -supplemented rats, whereas reduced glutathione was markedly higher than in control rats, especially after administration of AuNPs. Moreover, the kidney functions in addition to the fat profile scoring supported the protective potential of that dose of AuNPs. The beta cells revealed euchromatic nuclei with no evidence of separation of nuclear membrane. Conclusions: Our results showed that AuNPs improved many of the oxidative stress parameters (SOD, GPx and, CAT, plasma antioxidant capacity (ORAC and lipid profile

  1. The evolution of massive stars including mass loss - Presupernova models and explosion

    Science.gov (United States)

    Woosley, S. E.; Langer, Norbert; Weaver, Thomas A.

    1993-01-01

    The evolution of massive stars of 35, 40, 60, and 85 solar masses is followed through all stages of nuclear burning to the point of Fe core collapse. Critical nuclear reaction and mass-loss rates are varied. Efficient mass loss during the Wolf-Rayet (WR) stage is likely to lead to final masses as small as 4 solar masses. For a reasonable parameterization of the mass loss, there may be convergence of all WR stars, both single and in binaries, to a narrow band of small final masses. Our representative model, a 4.25 solar-mass WR presupernova derived from a 60 solar mass star, is followed through a simulated explosion, and its explosive nucleosynthesis and light curve are determined. Its properties are similar to those observed in Type Ib supernovae. The effects of the initial mass and mass loss on the presupernova structure of small mass WR models is also explored. Important properties of the presupernova star and its explosion can only be obtained by following the complete evolution starting on the main sequence.

  2. Model for external influences on cellular signal transduction pathways including cytosolic calcium oscillations

    Energy Technology Data Exchange (ETDEWEB)

    Eichwald, C.; Kaiser, F. [Technical Univ. of Darmstadt (Germany)

    1995-06-01

    Experiments on the effects of extremely-low-frequency (ELF) electric and magnetic fields on cells of the immune system, T-lymphocytes in particular, suggest that the external field interacts with the cell at the level of intracellular signal transduction pathways. These are directly connected with changes in the calcium-signaling processes of the cell. Based on these findings, a theoretical model for receptor-controlled cytosolic calcium oscillations and for external influences on the signal transduction pathway is presented. The authors discuss the possibility that the external field acts on the kinetics of the signal transduction between the activated receptors at the cell membrane and the G-proteins. It is shown that, depending on the specific combination of cell internal biochemical and external physical parameters, entirely different responses of the cell can occur. The authors compare the effects of a coherent (periodic) modulation and of incoherent perturbations (noise). The model and the calculations are based on the theory of self-sustained, nonlinear oscillators. It is argued that these systems form an ideal basis for information-encoding processes in biological systems.

  3. An Improved Heat Budget Estimation Including Bottom Effects for General Ocean Circulation Models

    Science.gov (United States)

    Carder, Kendall; Warrior, Hari; Otis, Daniel; Chen, R. F.

    2001-01-01

    This paper studies the effects of the underwater light field on heat-budget calculations of general ocean circulation models for shallow waters. The presence of a bottom significantly alters the estimated heat budget in shallow waters, which affects the corresponding thermal stratification and hence modifies the circulation. Based on the data collected during the COBOP field experiment near the Bahamas, we have used a one-dimensional turbulence closure model to show the influence of the bottom reflection and absorption on the sea surface temperature field. The water depth has an almost one-to-one correlation with the temperature rise. Effects of varying the bottom albedo by replacing the sea grass bed with a coral sand bottom, also has an appreciable effect on the heat budget of the shallow regions. We believe that the differences in the heat budget for the shallow areas will have an influence on the local circulation processes and especially on the evaporative and long-wave heat losses for these areas. The ultimate effects on humidity and cloudiness of the region are expected to be significant as well.

  4. Grids of stellar models including second harmonic and colours: Solar composition

    CERN Document Server

    Yildiz, Mutlu

    2015-01-01

    Grids of stellar evolution are required in many fields of astronomy/astrophysics, such as planet hosting stars, binaries, clusters, chemically peculiar stars, etc. In this study, a grid of stellar evolution models with updated ingredients and {recently determined solar abundaces} is presented. The solar values for the initial abundances of hydrogen, heavy elements and mixing-length parameter are 0.0172, 0.7024 and 1.98, respectively. The mass step is small enough (0.01 M$_\\odot$) that interpolation for a given star mass is not required. The range of stellar mass is 0.74 to 10.00 M$_\\odot$. We present results in different forms of tables for easy and general application. The second stellar harmonic, required for analysis of apsidal motion of eclipsing binaries, is also listed. We also construct rotating models to determine effect of rotation on stellar structure and derive fitting formula for luminosity, radius and the second stellar harmonic as a function of rotational parameter. We also compute and list colo...

  5. Description and Application of A Model of Seepage under A Weir Including Mechanical Clogging

    Directory of Open Access Journals (Sweden)

    Sroka Zbigniew

    2014-07-01

    Full Text Available The paper discusses seepage flow under a damming structure (a weir in view of mechanical clogging in a thin layer at the upstream site. It was assumed that in this layer flow may be treated as one-dimensional (perpendicular to the layer, while elsewhere flow was modelled as two-dimensional. The solution in both zones was obtained in the discrete form using the finite element method and the Euler method. The effect of the clogging layer on seepage flow was modelled using the third kind boundary condition. Seepage parameters in the clogging layer were estimated based on laboratory tests conducted by Skolasińska [2006]. Typical problem was taken to provide simulation and indicate how clogging affects the seepage rate and other parameters of the flow. Results showed that clogging at the upstream site has a significant effect on the distribution of seepage velocity and hydraulic gradients. The flow underneath the structure decreases with time, but these changes are relatively slow.

  6. Simulation of the contraction of the ventricles in a human heart model including atria and pericardium.

    Science.gov (United States)

    Fritz, Thomas; Wieners, Christian; Seemann, Gunnar; Steen, Henning; Dössel, Olaf

    2014-06-01

    During the contraction of the ventricles, the ventricles interact with the atria as well as with the pericardium and the surrounding tissue in which the heart is embedded. The atria are stretched, and the atrioventricular plane moves toward the apex. The atrioventricular plane displacement (AVPD) is considered to be a major contributor to the ventricular function, and a reduced AVPD is strongly related to heart failure. At the same time, the epicardium slides almost frictionlessly on the pericardium with permanent contact. Although the interaction between the ventricles, the atria and the pericardium plays an important role for the deformation of the heart, this aspect is usually not considered in computational models. In this work, we present an electromechanical model of the heart, which takes into account the interaction between ventricles, pericardium and atria and allows to reproduce the AVPD. To solve the contact problem of epicardium and pericardium, a contact handling algorithm based on penalty formulation was developed, which ensures frictionless and permanent contact. Two simulations of the ventricular contraction were conducted, one with contact handling of pericardium and heart and one without. In the simulation with contact handling, the atria were stretched during the contraction of the ventricles, while, due to the permanent contact with the pericardium, their volume increased. In contrast to that, in the simulations without pericardium, the atria were also stretched, but the change in the atrial volume was much smaller. Furthermore, the pericardium reduced the radial contraction of the ventricles and at the same time increased the AVPD.

  7. Effect of neurosteroids on a model lipid bilayer including cholesterol: An Atomic Force Microscopy study.

    Science.gov (United States)

    Sacchi, Mattia; Balleza, Daniel; Vena, Giulia; Puia, Giulia; Facci, Paolo; Alessandrini, Andrea

    2015-05-01

    Amphiphilic molecules which have a biological effect on specific membrane proteins, could also affect lipid bilayer properties possibly resulting in a modulation of the overall membrane behavior. In light of this consideration, it is important to study the possible effects of amphiphilic molecule of pharmacological interest on model systems which recapitulate some of the main properties of the biological plasma membranes. In this work we studied the effect of a neurosteroid, Allopregnanolone (3α,5α-tetrahydroprogesterone or Allo), on a model bilayer composed by the ternary lipid mixture DOPC/bSM/chol. We chose ternary mixtures which present, at room temperature, a phase coexistence of liquid ordered (Lo) and liquid disordered (Ld) domains and which reside near to a critical point. We found that Allo, which is able to strongly partition in the lipid bilayer, induces a marked increase in the bilayer area and modifies the relative proportion of the two phases favoring the Ld phase. We also found that the neurosteroid shifts the miscibility temperature to higher values in a way similarly to what happens when the cholesterol concentration is decreased. Interestingly, an isoform of Allo, isoAllopregnanolone (3β,5α-tetrahydroprogesterone or isoAllo), known to inhibit the effects of Allo on GABAA receptors, has an opposite effect on the bilayer properties.

  8. The evolution of massive stars including mass loss - Presupernova models and explosion

    Science.gov (United States)

    Woosley, S. E.; Langer, Norbert; Weaver, Thomas A.

    1993-01-01

    The evolution of massive stars of 35, 40, 60, and 85 solar masses is followed through all stages of nuclear burning to the point of Fe core collapse. Critical nuclear reaction and mass-loss rates are varied. Efficient mass loss during the Wolf-Rayet (WR) stage is likely to lead to final masses as small as 4 solar masses. For a reasonable parameterization of the mass loss, there may be convergence of all WR stars, both single and in binaries, to a narrow band of small final masses. Our representative model, a 4.25 solar-mass WR presupernova derived from a 60 solar mass star, is followed through a simulated explosion, and its explosive nucleosynthesis and light curve are determined. Its properties are similar to those observed in Type Ib supernovae. The effects of the initial mass and mass loss on the presupernova structure of small mass WR models is also explored. Important properties of the presupernova star and its explosion can only be obtained by following the complete evolution starting on the main sequence.

  9. Three-Dimensional Magnetohydrodynamic Modeling of the Solar Wind Including Pickup Protons and Turbulence Transport

    Science.gov (United States)

    Usmanov, Arcadi V.; Goldstein, Melvyn L.; Matthaeus, William H.

    2012-01-01

    To study the effects of interstellar pickup protons and turbulence on the structure and dynamics of the solar wind, we have developed a fully three-dimensional magnetohydrodynamic solar wind model that treats interstellar pickup protons as a separate fluid and incorporates the transport of turbulence and turbulent heating. The governing system of equations combines the mean-field equations for the solar wind plasma, magnetic field, and pickup protons and the turbulence transport equations for the turbulent energy, normalized cross-helicity, and correlation length. The model equations account for photoionization of interstellar hydrogen atoms and their charge exchange with solar wind protons, energy transfer from pickup protons to solar wind protons, and plasma heating by turbulent dissipation. Separate mass and energy equations are used for the solar wind and pickup protons, though a single momentum equation is employed under the assumption that the pickup protons are comoving with the solar wind protons.We compute the global structure of the solar wind plasma, magnetic field, and turbulence in the region from 0.3 to 100 AU for a source magnetic dipole on the Sun tilted by 0 deg - .90 deg and compare our results with Voyager 2 observations. The results computed with and without pickup protons are superposed to evaluate quantitatively the deceleration and heating effects of pickup protons, the overall compression of the magnetic field in the outer heliosphere caused by deceleration, and the weakening of corotating interaction regions by the thermal pressure of pickup protons.

  10. Perceptual-center modeling is affected by including acoustic rate-of-change modulations.

    Science.gov (United States)

    Harsin, C A

    1997-02-01

    This study investigated the acoustic correlates of perceptual centers (p-centers) in CV and VC syllables and developed an acoustic p-center model. In Part 1, listeners located syllables' p-centers by a method-of-adjustment procedure. The CV syllables contained the consonants /s/,/r/,/n/,/t/,/d/,/k/, and /g/; the VCs, the consonants /s/,/r/, and /n/. The vowel in all syllables was /a/. The results of this experiment replicated and extended previous findings regarding the effects of phonetic variation on p-centers. In Part 2, a digital signal processing procedure was used to acoustically model p-center perception. Each stimulus was passed through a six-band digital filter, and the outputs were processed to derive low-frequency modulation components. These components were weighted according to a perceived modulation magnitude function and recombined to create six psychoacoustic envelopes containing modulation energies from 3 to 47 Hz. In this analysis, p-centers were found to be highly correlated with the time-weighted function of the rate-of-change in the psychoacoustic envelopes, multiplied by the psychoacoustic envelope magnitude increment. The results were interpreted as suggesting (1) the probable role of low-frequency energy modulations in p-center perception, and (2) the presence of perceptual processes that integrate multiple articulatory events into a single syllabic event.

  11. Modelling the Colour of Strawberry Spread During Storage, Including Effects of Technical Variations

    Directory of Open Access Journals (Sweden)

    Kadivec Mirta

    2016-12-01

    Full Text Available The colour of freshly processed strawberry spread changes relatively rapidly from a bright red to a dull red, which then makes its appearance generally less acceptable for consumers. The colours of strawberry spreads following several processing conditions were measured under different storage conditions. Additional sugar and colorant had only slight effects on the colour decay, while exclusion of oxygen and daylight did not affect this process. The only condition that clearly maintained the freshly processed appearance was storage at 4°C. Hexagonal bottles were filled with the strawberry spreads and their colour was repeatedly measured at the six sides of the bottles, using a Minolta chroma meter. Data were analysed using non-linear indexed regression analysis based on a logistic function for the three colour aspect of a*, b* and L*. This technology allowed the determination of the variation in these data in terms of improved reliability (R2adj, >90%. It also allowed better interpretation of the processes involved. All variations in the data could be attributed to technical variation.

  12. Open Source Software for Mapping Human Impacts on Marine Ecosystems with an Additive Model

    Directory of Open Access Journals (Sweden)

    Andy Stock

    2016-06-01

    Full Text Available This paper describes an easy-to-use open source software tool implementing a commonly used additive model (Halpern et al., 'Science', 2008 for mapping human impacts on marine ecosystems. The tool has been used to map the potential for cumulative human impacts in Arctic marine waters and can support future human impact mapping projects by 1 making the model easier to use; 2 making updates of model results straightforward when better input data become available; 3 storing input data and information about processing steps in a defined format and thus facilitating data sharing and reproduction of modeling results; 4 supporting basic visualization of model inputs and outputs without the need for advanced technical skills. The tool, called EcoImpactMapper, was implemented in Java and is thus platform-independent. A tutorial, example data, the tool and the source code are available online.

  13. Estimation for an additive growth curve model with orthogonal design matrices

    CERN Document Server

    Hu, Jianhua; You, Jinhong; 10.3150/10-BEJ315

    2012-01-01

    An additive growth curve model with orthogonal design matrices is proposed in which observations may have different profile forms. The proposed model allows us to fit data and then estimate parameters in a more parsimonious way than the traditional growth curve model. Two-stage generalized least-squares estimators for the regression coefficients are derived where a quadratic estimator for the covariance of observations is taken as the first-stage estimator. Consistency, asymptotic normality and asymptotic independence of these estimators are investigated. Simulation studies and a numerical example are given to illustrate the efficiency and parsimony of the proposed model for model specifications in the sense of minimizing Akaike's information criterion (AIC).

  14. The additive nonparametric and semiparametric Aalen model as the rate function for a counting process

    DEFF Research Database (Denmark)

    Scheike, Thomas Harder

    2002-01-01

    We use the additive risk model of Aalen (Aalen, 1980) as a model for the rate of a counting process. Rather than specifying the intensity, that is the instantaneous probability of an event conditional on the entire history of the relevant covariates and counting processes, we present a model...... for the rate function, i.e., the instantaneous probability of an event conditional on only a selected set of covariates. When the rate function for the counting process is of Aalen form we show that the usual Aalen estimator can be used and gives almost unbiased estimates. The usual martingale based variance...... estimator is incorrect and an alternative estimator should be used. We also consider the semi-parametric version of the Aalen model as a rate model (McKeague and Sasieni, 1994) and show that the standard errors that are computed based on an assumption of intensities are incorrect and give a different...

  15. Experimental cell transplantation therapy in rat myocardial infarction model including nude rat preparation.

    Science.gov (United States)

    Dai, Wangde; Kloner, Robert A

    2010-01-01

    As a novel potential therapeutic strategy for cardiac disease, cell transplantation therapy has been extensively investigated in experimental studies and clinical trials. Although encouraging results have been demonstrated, a number of critical questions still remain to be answered. For example, what kind of stem cell and how many cells should be used; what is the best time for cell transplantation after acute myocardial infarction; which delivery approach is better, intravenous injection or direct intramyocardial injection? Transplantation of cells derived from human tissues into experimental animals may elicit an immune rejection. Immunodeficient nude rats provide a useful myocardial infarction model for cell transplantation therapy studies. We introduce our detailed methods of direct intramyocardial injection of immature heart cells and stem cells into the myocardial infarction region of rats and nude rats. Careful maintenance under aseptic conditions and proper surgical technique are essential to improve the survival of immunodeficient rats after surgery.

  16. Including ethical considerations in models for first-trimester screening for pre-eclampsia

    DEFF Research Database (Denmark)

    Jørgensen, Jennifer Maureen; Hedley, Paula L.; Gjerris, Mickey;

    2014-01-01

    Recent efforts to develop reliable and efficient early pregnancy screening programmes for pre-eclampsia have focused on com-bining clinical, biochemical and biophysical markers. The same model has been used for first-trimester screening for fetal aneuploidies i.e. prenatal diagnosis (PD), which...... is routinely offered to all pregnant women in many developed countries. Some studies suggest combining PD and pre-eclampsia screening, so women can be offered testing for a number of conditions at the same clinical visit. A combination of these tests may be practical in terms of saving time and resources......; however, the combination raises ethical issues. First-trimester PD and pre-eclampsia screening entail qualitative differences which alter the requirements for disclosure, non-directedness and consent with regard to the informed consent process. This article explores the differences related to the ethical...

  17. Memory of the Vernalized State in Plants including the Model Grass Brachypodium distachyon

    Directory of Open Access Journals (Sweden)

    Daniel P Woods

    2014-03-01

    Full Text Available Plant species that have a vernalization requirement exhibit variation in the ability to remember winter—i.e., variation in the stability of the vernalized state. Studies in Arabidopsis have demonstrated that molecular memory involves changes in the chromatin state and expression of the flowering repressor FLOWERING LOCUS C, and have revealed that single-gene differences can have large effects on the stability of the vernalized state. In the perennial Arabidopsis relative Arabis alpina, the lack of memory of winter is critical for its perennial life history. Our studies of flowering behavior in the model grass Brachypodium distachyon reveal extensive variation in the vernalization requirement, and studies of a particular Brachypodium accession that has a qualitative requirement for both cold exposure and inductive daylength reveals that Brachypodium can exhibit a highly stable vernalized state.

  18. The economic production lot size model extended to include more than one production rate

    DEFF Research Database (Denmark)

    Larsen, Christian

    2001-01-01

    btween the demand rate and the production rate which minimizes unit production costs, and should be used in an increasing order. Then, given the production rates, we derive closed-form expressions for all optimal runtimes as well as the minimum average cost. This analysis reveals that it is the size......We study an extension of the economic production lot size model, where more than one production rate can be used during a cycle. Moreover, the production rates, as well as their corresponding runtimes are decision variables. First, we show that all production rates should be choosen in the interval...... of the setup cost that determines the need for being able to use several production rates. Finally, we show how to derive a near-optimal solution of the general problem....

  19. The economic production lot size model extended to include more than one production rate

    DEFF Research Database (Denmark)

    Larsen, Christian

    2005-01-01

    production rates should be chosen in the interval between the demand rate and the production rate which minimizes unit production costs, and should be used in an increasing order. Then, given the production rates, we derive closed-form expressions for all optimal runtimes as well as the minimum average cost......We study an extension of the economic production lot size model, where more than one production rate can be used during a cycle. Moreover, the production rates, as well as their corresponding runtimes are decision variables. We decompose the problem into two subproblems. First, we show that all....... This analysis reveals that it is the size of the setup cost that determines the need for being able to use several production rates. We also show how to derive a near-optimal solution of the general problem....

  20. Modelling of safety barriers including human and organisational factors to improve process safety

    DEFF Research Database (Denmark)

    Markert, Frank; Duijm, Nijs Jan; Thommesen, Jacob

    2013-01-01

    explosion, and the Mont Blanc Tunnel Fire, such an approach may have helped to maintain the integrity of the designed provisions against major deviations resulting in these disasters. In order to make this paradigm operational, safety management and in particular risk assessment tools need to be refined....... A valuable approach is the inclusion of human and organisational factors into the simulation of the reliability of the technical system using event trees and fault trees and the concept of safety barriers. This has been demonstrated e.g. in the former European research project ARAMIS (Accidental Risk...... Assessment Methodology for IndustrieS, see Salvi et al 2006). ARAMIS employs the bow-tie approach to modelling hazardous scenarios, and it suggests the outcome of auditing safety management to be connected to a semi-quantitative assessment of the quality of safety barriers. ARAMIS discriminates a number...

  1. Non-insect crustacean models in developmental genetics including an encomium to Parhyale hawaiensis.

    Science.gov (United States)

    Stamataki, Evangelia; Pavlopoulos, Anastasios

    2016-08-01

    The impressive diversity of body plans, lifestyles and segmental specializations exhibited by crustaceans (barnacles, copepods, shrimps, crabs, lobsters and their kin) provides great material to address longstanding questions in evolutionary developmental biology. Recent advances in forward and reverse genetics and in imaging approaches applied in the amphipod Parhyale hawaiensis and other emerging crustacean model species have made it possible to probe the molecular and cellular basis of crustacean diversity. A number of biological and technical qualities like the slow tempo and holoblastic cleavage mode, the stereotypy of many cellular processes, the functional and morphological diversity of limbs along the body axis, and the availability of various experimental manipulations, have made Parhyale a powerful system to study normal development and regeneration. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Robust and Adaptive OMR System Including Fuzzy Modeling, Fusion of Musical Rules, and Possible Error Detection

    Directory of Open Access Journals (Sweden)

    Isabelle Bloch

    2007-01-01

    Full Text Available This paper describes a system for optical music recognition (OMR in case of monophonic typeset scores. After clarifying the difficulties specific to this domain, we propose appropriate solutions at both image analysis level and high-level interpretation. Thus, a recognition and segmentation method is designed, that allows dealing with common printing defects and numerous symbol interconnections. Then, musical rules are modeled and integrated, in order to make a consistent decision. This high-level interpretation step relies on the fuzzy sets and possibility framework, since it allows dealing with symbol variability, flexibility, and imprecision of music rules, and merging all these heterogeneous pieces of information. Other innovative features are the indication of potential errors and the possibility of applying learning procedures, in order to gain in robustness. Experiments conducted on a large data base show that the proposed method constitutes an interesting contribution to OMR.

  3. Robust and Adaptive OMR System Including Fuzzy Modeling, Fusion of Musical Rules, and Possible Error Detection

    Science.gov (United States)

    Rossant, Florence; Bloch, Isabelle

    2006-12-01

    This paper describes a system for optical music recognition (OMR) in case of monophonic typeset scores. After clarifying the difficulties specific to this domain, we propose appropriate solutions at both image analysis level and high-level interpretation. Thus, a recognition and segmentation method is designed, that allows dealing with common printing defects and numerous symbol interconnections. Then, musical rules are modeled and integrated, in order to make a consistent decision. This high-level interpretation step relies on the fuzzy sets and possibility framework, since it allows dealing with symbol variability, flexibility, and imprecision of music rules, and merging all these heterogeneous pieces of information. Other innovative features are the indication of potential errors and the possibility of applying learning procedures, in order to gain in robustness. Experiments conducted on a large data base show that the proposed method constitutes an interesting contribution to OMR.

  4. Parsing recursive sentences with a connectionist model including a neural stack and synaptic gating.

    Science.gov (United States)

    Fedor, Anna; Ittzés, Péter; Szathmáry, Eörs

    2011-02-21

    It is supposed that humans are genetically predisposed to be able to recognize sequences of context-free grammars with centre-embedded recursion while other primates are restricted to the recognition of finite state grammars with tail-recursion. Our aim was to construct a minimalist neural network that is able to parse artificial sentences of both grammars in an efficient way without using the biologically unrealistic backpropagation algorithm. The core of this network is a neural stack-like memory where the push and pop operations are regulated by synaptic gating on the connections between the layers of the stack. The network correctly categorizes novel sentences of both grammars after training. We suggest that the introduction of the neural stack memory will turn out to be substantial for any biological 'hierarchical processor' and the minimalist design of the model suggests a quest for similar, realistic neural architectures.

  5. ECO: a generic eutrophication model including comprehensive sediment-water interaction.

    Directory of Open Access Journals (Sweden)

    Johannes G C Smits

    Full Text Available The content and calibration of the comprehensive generic 3D eutrophication model ECO for water and sediment quality is presented. Based on a computational grid for water and sediment, ECO is used as a tool for water quality management to simulate concentrations and mass fluxes of nutrients (N, P, Si, phytoplankton species, detrital organic matter, electron acceptors and related substances. ECO combines integral simulation of water and sediment quality with sediment diagenesis and closed mass balances. Its advanced process formulations for substances in the water column and the bed sediment were developed to allow for a much more dynamic calculation of the sediment-water exchange fluxes of nutrients as resulting from steep concentration gradients across the sediment-water interface than is possible with other eutrophication models. ECO is to more accurately calculate the accumulation of organic matter and nutrients in the sediment, and to allow for more accurate prediction of phytoplankton biomass and water quality in response to mitigative measures such as nutrient load reduction. ECO was calibrated for shallow Lake Veluwe (The Netherlands. Due to restoration measures this lake underwent a transition from hypertrophic conditions to moderately eutrophic conditions, leading to the extensive colonization by submerged macrophytes. ECO reproduces observed water quality well for the transition period of ten years. The values of its process coefficients are in line with ranges derived from literature. ECO's calculation results underline the importance of redox processes and phosphate speciation for the nutrient return fluxes. Among other things, the results suggest that authigenic formation of a stable apatite-like mineral in the sediment can contribute significantly to oligotrophication of a lake after a phosphorus load reduction.

  6. Parameterization of cloud droplet formation for global and regional models: including adsorption activation from insoluble CCN

    Directory of Open Access Journals (Sweden)

    P. Kumar

    2009-04-01

    Full Text Available Dust and black carbon aerosol have long been known to exert potentially important and diverse impacts on cloud droplet formation. Most studies to date focus on the soluble fraction of these particles, and overlook interactions of the insoluble fraction with water vapor (even if known to be hydrophilic. To address this gap, we developed a new parameterization that considers cloud droplet formation within an ascending air parcel containing insoluble (but wettable particles externally mixed with aerosol containing an appreciable soluble fraction. Activation of particles with a soluble fraction is described through well-established Köhler theory, while the activation of hydrophilic insoluble particles is treated by "adsorption-activation" theory. In the latter, water vapor is adsorbed onto insoluble particles, the activity of which is described by a multilayer Frenkel-Halsey-Hill (FHH adsorption isotherm modified to account for particle curvature. We further develop FHH activation theory to i find combinations of the adsorption parameters AFHH, BFHH which yield atmospherically-relevant behavior, and, ii express activation properties (critical supersaturation that follow a simple power law with respect to dry particle diameter.

    The new parameterization is tested by comparing the parameterized cloud droplet number concentration against predictions with a detailed numerical cloud model, considering a wide range of particle populations, cloud updraft conditions, water vapor condensation coefficient and FHH adsorption isotherm characteristics. The agreement between parameterization and parcel model is excellent, with an average error of 10% and R2~0.98. A preliminary sensitivity study suggests that the sublinear response of droplet number to Köhler particle concentration is not as strong for FHH particles.

  7. Parameterization of cloud droplet formation for global and regional models: including adsorption activation from insoluble CCN

    Science.gov (United States)

    Kumar, P.; Sokolik, I. N.; Nenes, A.

    2009-04-01

    Dust and black carbon aerosol have long been known to exert potentially important and diverse impacts on cloud droplet formation. Most studies to date focus on the soluble fraction of these particles, and overlook interactions of the insoluble fraction with water vapor (even if known to be hydrophilic). To address this gap, we developed a new parameterization that considers cloud droplet formation within an ascending air parcel containing insoluble (but wettable) particles externally mixed with aerosol containing an appreciable soluble fraction. Activation of particles with a soluble fraction is described through well-established Köhler theory, while the activation of hydrophilic insoluble particles is treated by "adsorption-activation" theory. In the latter, water vapor is adsorbed onto insoluble particles, the activity of which is described by a multilayer Frenkel-Halsey-Hill (FHH) adsorption isotherm modified to account for particle curvature. We further develop FHH activation theory to i) find combinations of the adsorption parameters AFHH, BFHH which yield atmospherically-relevant behavior, and, ii) express activation properties (critical supersaturation) that follow a simple power law with respect to dry particle diameter. The new parameterization is tested by comparing the parameterized cloud droplet number concentration against predictions with a detailed numerical cloud model, considering a wide range of particle populations, cloud updraft conditions, water vapor condensation coefficient and FHH adsorption isotherm characteristics. The agreement between parameterization and parcel model is excellent, with an average error of 10% and R2~0.98. A preliminary sensitivity study suggests that the sublinear response of droplet number to Köhler particle concentration is not as strong for FHH particles.

  8. ECO: a generic eutrophication model including comprehensive sediment-water interaction.

    Science.gov (United States)

    Smits, Johannes G C; van Beek, Jan K L

    2013-01-01

    The content and calibration of the comprehensive generic 3D eutrophication model ECO for water and sediment quality is presented. Based on a computational grid for water and sediment, ECO is used as a tool for water quality management to simulate concentrations and mass fluxes of nutrients (N, P, Si), phytoplankton species, detrital organic matter, electron acceptors and related substances. ECO combines integral simulation of water and sediment quality with sediment diagenesis and closed mass balances. Its advanced process formulations for substances in the water column and the bed sediment were developed to allow for a much more dynamic calculation of the sediment-water exchange fluxes of nutrients as resulting from steep concentration gradients across the sediment-water interface than is possible with other eutrophication models. ECO is to more accurately calculate the accumulation of organic matter and nutrients in the sediment, and to allow for more accurate prediction of phytoplankton biomass and water quality in response to mitigative measures such as nutrient load reduction. ECO was calibrated for shallow Lake Veluwe (The Netherlands). Due to restoration measures this lake underwent a transition from hypertrophic conditions to moderately eutrophic conditions, leading to the extensive colonization by submerged macrophytes. ECO reproduces observed water quality well for the transition period of ten years. The values of its process coefficients are in line with ranges derived from literature. ECO's calculation results underline the importance of redox processes and phosphate speciation for the nutrient return fluxes. Among other things, the results suggest that authigenic formation of a stable apatite-like mineral in the sediment can contribute significantly to oligotrophication of a lake after a phosphorus load reduction.

  9. Field theory of bicritical and tetracritical points. III. Relaxational dynamics including conservation of magnetization (model C).

    Science.gov (United States)

    Folk, R; Holovatch, Yu; Moser, G

    2009-03-01

    We calculate the relaxational dynamical critical behavior of systems of O(n_{ parallel}) plus sign in circleO(n_{ perpendicular}) symmetry including conservation of magnetization by renormalization group theory within the minimal subtraction scheme in two-loop order. Within the stability region of the Heisenberg fixed point and the biconical fixed point, strong dynamical scaling holds, with the asymptotic dynamical critical exponent z=2varphinu-1 , where varphi is the crossover exponent and nu the exponent of the correlation length. The critical dynamics at n_{ parallel}=1 and n_{ perpendicular}=2 is governed by a small dynamical transient exponent leading to nonuniversal nonasymptotic dynamical behavior. This may be seen, e.g., in the temperature dependence of the magnetic transport coefficients.

  10. EFFECT OF NANOPOWDER ADDITION ON THE FLEXURAL STRENGTH OF ALUMINA CERAMIC - A WEIBULL MODEL ANALYSIS

    Directory of Open Access Journals (Sweden)

    Daidong Guo

    2016-05-01

    Full Text Available Alumina ceramics were prepared either with micrometer-sized alumina powder (MAP or with the addition of nanometer-sized alumina powder (NAP. The density, crystalline phase, flexural strength and the fracture surface of the two ceramics were measured and compared. Emphasis has been put on the influence of nanopowder addition on the flexural strength of Al₂O₃ ceramic. The analysis based on the Weibull distribution model suggests the distribution of the flexural strength of the NAP ceramic is more concentrated than that of the MAP ceramic. Therefore, the NAP ceramics will be more stable and reliable in real applications.

  11. Efficient semiparametric estimation in generalized partially linear additive models for longitudinal/clustered data

    KAUST Repository

    Cheng, Guang

    2014-02-01

    We consider efficient estimation of the Euclidean parameters in a generalized partially linear additive models for longitudinal/clustered data when multiple covariates need to be modeled nonparametrically, and propose an estimation procedure based on a spline approximation of the nonparametric part of the model and the generalized estimating equations (GEE). Although the model in consideration is natural and useful in many practical applications, the literature on this model is very limited because of challenges in dealing with dependent data for nonparametric additive models. We show that the proposed estimators are consistent and asymptotically normal even if the covariance structure is misspecified. An explicit consistent estimate of the asymptotic variance is also provided. Moreover, we derive the semiparametric efficiency score and information bound under general moment conditions. By showing that our estimators achieve the semiparametric information bound, we effectively establish their efficiency in a stronger sense than what is typically considered for GEE. The derivation of our asymptotic results relies heavily on the empirical processes tools that we develop for the longitudinal/clustered data. Numerical results are used to illustrate the finite sample performance of the proposed estimators. © 2014 ISI/BS.

  12. The effect of tailor-made additives on crystal growth of methyl paraben: Experiments and modelling

    Science.gov (United States)

    Cai, Zhihui; Liu, Yong; Song, Yang; Guan, Guoqiang; Jiang, Yanbin

    2017-03-01

    In this study, methyl paraben (MP) was selected as the model component, and acetaminophen (APAP), p-methyl acetanilide (PMAA) and acetanilide (ACET), which share the similar molecular structure as MP, were selected as the three tailor-made additives to study the effect of tailor-made additives on the crystal growth of MP. HPLC results indicated that the MP crystals induced by the three additives contained MP only. Photographs of the single crystals prepared indicated that the morphology of the MP crystals was greatly changed by the additives, but PXRD and single crystal diffraction results illustrated that the MP crystals were the same polymorph only with different crystal habits, and no new crystal form was found compared with other references. To investigate the effect of the additives on the crystal growth, the interaction between additives and facets was discussed in detail using the DFT methods and MD simulations. The results showed that APAP, PMAA and ACET would be selectively adsorbed on the growth surfaces of the crystal facets, which induced the change in MP crystal habits.

  13. A flexible additive inflation scheme for treating model error in ensemble Kalman Filters

    Science.gov (United States)

    Sommer, Matthias; Janjic, Tijana

    2017-04-01

    Data assimilation algorithms require an accurate estimate of the uncertainty of the prior, background, field. However, the background error covariance derived from the ensemble of numerical model simulations does not adequately represent the uncertainty of it. This is partially due to the sampling error that arises from the use of a small number of ensemble members to represent the background error covariance. It is also partially a consequence of the fact that the model does not represent its own error. Several mechanisms have been introduced so far aiming at alleviating the detrimental e ffects of misrepresented ensemble covariances, allowing for the successful implementation of ensemble data assimilation techniques for atmospheric dynamics. One of the established approaches in ensemble data assimilation is additive inflation which perturbs each ensemble member with a sample from a given distribution. This results in a fixed rank of the model error covariance matrix. Here, a more flexible approach is suggested where the model error samples are treated as additional synthetic ensemble members which are used in the update step of data assimilation but are not forecast. In this way, the rank of the model error covariance matrix can be chosen independently of the ensemble. The eff ect of this altered additive inflation method on the performance of the filter is analyzed here in an idealised experiment. It is shown that the additional synthetic ensemble members can make it feasible to achieve convergence in an otherwise divergent setting of data assimilation. The use of this method also allows for a less stringent localization radius.

  14. Nuclear Reactor/Hydrogen Process Interface Including the HyPEP Model

    Energy Technology Data Exchange (ETDEWEB)

    Steven R. Sherman

    2007-05-01

    The Nuclear Reactor/Hydrogen Plant interface is the intermediate heat transport loop that will connect a very high temperature gas-cooled nuclear reactor (VHTR) to a thermochemical, high-temperature electrolysis, or hybrid hydrogen production plant. A prototype plant called the Next Generation Nuclear Plant (NGNP) is planned for construction and operation at the Idaho National Laboratory in the 2018-2021 timeframe, and will involve a VHTR, a high-temperature interface, and a hydrogen production plant. The interface is responsible for transporting high-temperature thermal energy from the nuclear reactor to the hydrogen production plant while protecting the nuclear plant from operational disturbances at the hydrogen plant. Development of the interface is occurring under the DOE Nuclear Hydrogen Initiative (NHI) and involves the study, design, and development of high-temperature heat exchangers, heat transport systems, materials, safety, and integrated system models. Research and development work on the system interface began in 2004 and is expected to continue at least until the start of construction of an engineering-scale demonstration plant.

  15. Landau quantized dynamics and spectra for group-VI dichalcogenides, including a model quantum wire

    Directory of Open Access Journals (Sweden)

    Norman J. M. Horing

    2017-06-01

    Full Text Available This work is concerned with the derivation of the Green’s function for Landau-quantized carriers in the Group-VI dichalcogenides. In the spatially homogeneous case, the Green’s function is separated into a Peierls phase factor and a translationally invariant part which is determined in a closed form integral representation involving only elementary functions. The latter is expanded in an eigenfunction series of Laguerre polynomials. These results for the retarded Green’s function are presented in both position and momentum representations, and yet another closed form representation is derived in circular coordinates in terms of the Bessel wave function of the second kind (not to be confused with the Bessel function. The case of a quantum wire is also addressed, representing the quantum wire in terms of a model one-dimensional δ(x-potential profile. This retarded Green’s function for propagation directly along the wire is determined exactly in terms of the corresponding Green’s function for the system without the δ(x-potential, and the Landau quantized eigenenergy dispersion relation is examined. The thermodynamic Green’s function for the dichalcogenide carriers in a normal magnetic field is formulated here in terms of its spectral weight, and its solution is presented in a momentum/integral representation involving only elementary functions, which is subsequently expanded in Laguerre eigenfunctions and presented in both momentum and position representations.

  16. A fully model-based MPC solution including VSB shot dose assignment and shape correction

    Science.gov (United States)

    Bork, Ingo; Buck, Peter; Reddy, Murali; Durvasula, Bhardwaj

    2015-10-01

    The value of using multiple dose levels for individual shots on VSB (Variable Shaped Beam) mask writers has been demonstrated earlier [1][2]. The main advantage of modulating dose on a per shot basis is the fact that higher dose levels can be used selectively for critical features while other areas of the mask with non-critical feature types can be exposed at lower dose levels. This reduces the amount of backscattering and mask write time penalty compared to a global overdose-undersize approach. While dose assignment to certain polygons or parts of polygons (VSB shots) can easily be accomplished via DRC rules on layers with limited shape variations like contact or VIA layers, it can be challenging to come up with consistent rules for layers consisting of a very broad range of shapes, generally found on metal layers. This work introduces a method for fully model-based modulation of shot dose for VSB machines supporting between two and eight dose levels and demonstrates results achieved with this method.

  17. Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model

    Science.gov (United States)

    Pilgrim, Matthew G.; Lengyel, Imre; Lanzirotti, Antonio; Newville, Matt; Fearn, Sarah; Emri, Eszter; Knowles, Jonathan C.; Messinger, Jeffrey D.; Read, Russell W.; Guidry, Clyde; Curcio, Christine A.

    2017-01-01

    Purpose Extracellular deposits containing hydroxyapatite, lipids, proteins, and trace metals that form between the basal lamina of the RPE and the inner collagenous layer of Bruch's membrane are hallmarks of early AMD. We examined whether cultured RPE cells could produce extracellular deposits containing all of these molecular components. Methods Retinal pigment epithelium cells isolated from freshly enucleated porcine eyes were cultured on Transwell membranes for up to 6 months. Deposit composition and structure were characterized using light, fluorescence, and electron microscopy; synchrotron x-ray diffraction and x-ray fluorescence; secondary ion mass spectroscopy; and immunohistochemistry. Results Apparently functional primary RPE cells, when cultured on 10-μm-thick inserts with 0.4-μm-diameter pores, can produce sub-RPE deposits that contain hydroxyapatite, lipids, proteins, and trace elements, without outer segment supplementation, by 12 weeks. Conclusions The data suggest that sub-RPE deposit formation is initiated, and probably regulated, by the RPE, as well as the loss of permeability of the Bruch's membrane and choriocapillaris complex associated with age and early AMD. This cell culture model of early AMD lesions provides a novel system for testing new therapeutic interventions against sub-RPE deposit formation, an event occurring well in advance of the onset of vision loss. PMID:28146236

  18. Landau quantized dynamics and spectra for group-VI dichalcogenides, including a model quantum wire

    Science.gov (United States)

    Horing, Norman J. M.

    2017-06-01

    This work is concerned with the derivation of the Green's function for Landau-quantized carriers in the Group-VI dichalcogenides. In the spatially homogeneous case, the Green's function is separated into a Peierls phase factor and a translationally invariant part which is determined in a closed form integral representation involving only elementary functions. The latter is expanded in an eigenfunction series of Laguerre polynomials. These results for the retarded Green's function are presented in both position and momentum representations, and yet another closed form representation is derived in circular coordinates in terms of the Bessel wave function of the second kind (not to be confused with the Bessel function). The case of a quantum wire is also addressed, representing the quantum wire in terms of a model one-dimensional δ (x ) -potential profile. This retarded Green's function for propagation directly along the wire is determined exactly in terms of the corresponding Green's function for the system without the δ (x ) -potential, and the Landau quantized eigenenergy dispersion relation is examined. The thermodynamic Green's function for the dichalcogenide carriers in a normal magnetic field is formulated here in terms of its spectral weight, and its solution is presented in a momentum/integral representation involving only elementary functions, which is subsequently expanded in Laguerre eigenfunctions and presented in both momentum and position representations.

  19. Going beyond efficiency: including altruistic motives in behavioral models for sustainability transitions to address sufficiency

    Directory of Open Access Journals (Sweden)

    Niko Schäpke

    2014-07-01

    Full Text Available Sustainability transitions require altered individual behaviors. Policies aimed at changing people’s consumption behavior are designed according to efficiency, consistency, and sufficiency principles. Taking into account shortcomings of the first two principles, this paper specifically addresses the sufficiency principle. Sufficiency policies are not very popular due to the fear that they may impede quality of life. This fear might be eased when highlighting the motivational side of sustainable behavior, such as the wish to care for future generations and the world’s poor. This article uses the capability approach (CA, developed primarily by Nobel-laureate economist Amartya Sen (1987a and philosopher Martha Nussbaum (1993, 2000, to a include the differentiation between self- and other-oriented goals and behavior, b build on its demonstrated success in assessing quality of life, and c assess the sustainability of behavior and policies. These three facets make CA suitable to analyze the effectiveness of sufficiency policies on sustainability and quality of life. To better understand the motivational side of sustainable behavior, CA is here for the first time enriched through approaches from environmental psychology. This enables us to highlight the idea of intrinsic empowerment as a building block for sufficiency policies. We close the article by highlighting further avenues for research.

  20. Test of the Additivity Principle for Current Fluctuations in a Model of Heat Conduction

    Science.gov (United States)

    Hurtado, Pablo I.; Garrido, Pedro L.

    2009-06-01

    The additivity principle allows to compute the current distribution in many one-dimensional (1D) nonequilibrium systems. Using simulations, we confirm this conjecture in the 1D Kipnis-Marchioro-Presutti model of heat conduction for a wide current interval. The current distribution shows both Gaussian and non-Gaussian regimes, and obeys the Gallavotti-Cohen fluctuation theorem. We verify the existence of a well-defined temperature profile associated to a given current fluctuation. This profile is independent of the sign of the current, and this symmetry extends to higher-order profiles and spatial correlations. We also show that finite-time joint fluctuations of the current and the profile are described by the additivity functional. These results suggest the additivity hypothesis as a general and powerful tool to compute current distributions in many nonequilibrium systems.

  1. Use of additive technologies for practical working with complex models for foundry technologies

    Science.gov (United States)

    Olkhovik, E.; Butsanets, A. A.; Ageeva, A. A.

    2016-07-01

    The article presents the results of research of additive technology (3D printing) application for developing a geometrically complex model of castings parts. Investment casting is well known and widely used technology for the production of complex parts. The work proposes the use of a 3D printing technology for manufacturing models parts, which are removed by thermal destruction. Traditional methods of equipment production for investment casting involve the use of manual labor which has problems with dimensional accuracy, and CNC technology which is less used. Such scheme is low productive and demands considerable time. We have offered an alternative method which consists in printing the main knots using a 3D printer (PLA and ABS) with a subsequent production of castings models from them. In this article, the main technological methods are considered and their problems are discussed. The dimensional accuracy of models in comparison with investment casting technology is considered as the main aspect.

  2. Modeling of sulfation of potassium chloride by ferric sulfate addition during grate-firing of biomass

    DEFF Research Database (Denmark)

    Wu, Hao; Jespersen, Jacob Boll; Aho, Martti

    2013-01-01

    Potassium chloride, KCl, formed from critical ash-forming elements released during combustion may lead to severe ash deposition and corrosion problems in biomass-fired boilers. Ferric sulfate, Fe2(SO4)3 is an effective additive, which produces sulfur oxides (SO2 and SO3) to convert KCl to the less...... harmful K2SO4. In the present study the decomposition of ferric sulfate is studied in a fast-heating rate thermogravimetric analyzer (TGA), and a kinetic model is proposed to describe the decomposition process. The yields of SO2 and SO3 from ferric sulfate decomposition are investigated in a laboratory......-scale tube reactor. It is revealed that approximately 40% of the sulfur is released as SO3, the remaining fraction being released as SO2. The proposed decomposition model of ferric sulfate is combined with a detailed gas phase kinetic model of KCl sulfation, and a simplified model of K2SO4 condensation...

  3. Modeling the Use of Sulfate Additives for Potassium Chloride Destruction in Biomass Combustion

    DEFF Research Database (Denmark)

    Wu, Hao; Pedersen, Morten Nedergaard; Jespersen, Jacob Boll;

    2014-01-01

    Potassium chloride, KCl, formed from biomass combustion may lead to ash deposition and corrosion problems in boilers. Sulfates are effective additives for converting KCl to the less harmful K2SO4 and HCl. In the present study, the rate constants for decomposition of ammonium sulfate and aluminum...... sulfate were obtained from experiments in a fast heating rate thermogravimetric analyzer. The yields of SO2 and SO3 from the decomposition were investigated in a tube reactor at 600–900 °C, revealing a constant distribution of about 15% SO2 and 85% SO3 from aluminum sulfate decomposition and a temperature......-dependent distribution of SO2 and SO3 from ammonium sulfate decomposition. On the basis of these data as well as earlier results, a detailed chemical kinetic model for sulfation of KCl by a range of sulfate additives was established. Modeling results were compared to biomass combustion experiments in a bubbling...

  4. Model for Assembly Line Re-Balancing Considering Additional Capacity and Outsourcing to Face Demand Fluctuations

    Science.gov (United States)

    Samadhi, TMAA; Sumihartati, Atin

    2016-02-01

    The most critical stage in a garment industry is sewing process, because generally, it consists of a number of operations and a large number of sewing machines for each operation. Therefore, it requires a balancing method that can assign task to work station with balance workloads. Many studies on assembly line balancing assume a new assembly line, but in reality, due to demand fluctuation and demand increased a re-balancing is needed. To cope with those fluctuating demand changes, additional capacity can be carried out by investing in spare sewing machine and paying for sewing service through outsourcing. This study develops an assembly line balancing (ALB) model on existing line to cope with fluctuating demand change. Capacity redesign is decided if the fluctuation demand exceeds the available capacity through a combination of making investment on new machines and outsourcing while considering for minimizing the cost of idle capacity in the future. The objective of the model is to minimize the total cost of the line assembly that consists of operating costs, machine cost, adding capacity cost, losses cost due to idle capacity and outsourcing costs. The model develop is based on an integer programming model. The model is tested for a set of data of one year demand with the existing number of sewing machines of 41 units. The result shows that additional maximum capacity up to 76 units of machine required when there is an increase of 60% of the average demand, at the equal cost parameters..

  5. Patient-specific in vitro models for hemodynamic analysis of congenital heart disease - Additive manufacturing approach.

    Science.gov (United States)

    Medero, Rafael; García-Rodríguez, Sylvana; François, Christopher J; Roldán-Alzate, Alejandro

    2017-03-21

    Non-invasive hemodynamic assessment of total cavopulmonary connection (TCPC) is challenging due to the complex anatomy. Additive manufacturing (AM) is a suitable alternative for creating patient-specific in vitro models for flow measurements using four-dimensional (4D) Flow MRI. These in vitro systems have the potential to serve as validation for computational fluid dynamics (CFD), simulating different physiological conditions. This study investigated three different AM technologies, stereolithography (SLA), selective laser sintering (SLS) and fused deposition modeling (FDM), to determine differences in hemodynamics when measuring flow using 4D Flow MRI. The models were created using patient-specific MRI data from an extracardiac TCPC. These models were connected to a perfusion pump circulating water at three different flow rates. Data was processed for visualization and quantification of velocity, flow distribution, vorticity and kinetic energy. These results were compared between each model. In addition, the flow distribution obtained in vitro was compared to in vivo. The results showed significant difference in velocities measured at the outlets of the models that required internal support material when printing. Furthermore, an ultrasound flow sensor was used to validate flow measurements at the inlets and outlets of the in vitro models. These results were highly correlated to those measured with 4D Flow MRI. This study showed that commercially available AM technologies can be used to create patient-specific vascular models for in vitro hemodynamic studies at reasonable costs. However, technologies that do not require internal supports during manufacturing allow smoother internal surfaces, which makes them better suited for flow analyses. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Direct radiative effect modeled for regional aerosols in central Europe including the effect of relative humidity

    Science.gov (United States)

    Iorga, G.; Hitzenberger, R.; Kasper-Giebl, A.; Puxbaum, Hans

    2007-01-01

    In view of both the climatic relevance of aerosols and the fact that aerosol burdens in central Europe are heavily impacted by anthropogenic sources, this study is focused on estimating the regional-scale direct radiative effect of aerosols in Austria. The aerosol data (over 80 samples in total) were collected during measurement campaigns at five sampling sites: the urban areas of Vienna, Linz, and Graz and on Mt. Rax (1644 m, regional background aerosol) and Mt. Sonnblick (3106 m, background aerosol). Aerosol mass size distributions were obtained with eight-stage (size range: 0.06-16 μm diameter) and six-stage (size range 0.1-10 μm) low-pressure cascade impactors. The size-segregated samples were analyzed for total carbon (TC), black carbon (BC), and inorganic ions. The aerosol at these five locations is compared in terms of size distributions, optical properties, and direct forcing. Mie calculations are performed for the dry aerosol at 60 wavelengths in the range 0.3-40 μm. Using mass growth factors determined earlier, the optical properties are also estimated for higher relative humidities (60%, 70%, 80%, and 90%). A box model was used to estimate direct radiative forcing (DRF). The presence of absorbing species (BC) was found to reduce the cooling effect of the aerosols. The water-soluble substances dominate radiative forcing at the urban sites, while on Rax and Sonnblick BC plays the most important role. This result can be explained by the effect of the surface albedo, which is much lower in the urban regions (0.16) than at the ice and snow-covered mountain sites. Shortwave (below 4 μm) and longwave surface albedo values for ice were 0.35 and 0.5, while for snow surface albedo, values of 0.8 (shortwave) and 0.5 (longwave) were used. In the case of dry aerosol, especially for urban sites, the unidentified material may contribute a large part to the forcing. Depending on the sampling site the estimated forcing gets more negative with increasing humidity

  7. The Additive Risk Model for Estimation of Effect of Haplotype Match in BMT Studies

    DEFF Research Database (Denmark)

    Scheike, Thomas; Martinussen, T; Zhang, MJ

    2011-01-01

    leads to a missing data problem. We show how Aalen's additive risk model can be applied in this setting with the benefit that the time-varying haplomatch effect can be easily studied. This problem has not been considered before, and the standard approach where one would use the expected-maximization (EM...... be developed using product-integration theory. Small sample properties are investigated using simulations in a setting that mimics the motivating haplomatch problem....

  8. Application of power addition as modelling technique for flow processes: Two case studies

    CSIR Research Space (South Africa)

    de Wet, P

    2010-05-01

    Full Text Available addition as modelling technique for flow processes: Two case studies Pierre de Wet a,�, J. Prieur du Plessis b, Sonia Woudberg b a Council for Scientific & Industrial Research (CSIR), PO Box 320, Stellenbosch 7599, South Africa b Applied Mathematics... research on precise, credible experimental practices is undeniable. The empirical equations derived from these investigations impart understanding of the underlying physics are crucial for the development of computational routines and form an integral...

  9. Development of a QTL-environment-based predictive model for node addition rate in common bean.

    Science.gov (United States)

    Zhang, Li; Gezan, Salvador A; Eduardo Vallejos, C; Jones, James W; Boote, Kenneth J; Clavijo-Michelangeli, Jose A; Bhakta, Mehul; Osorno, Juan M; Rao, Idupulapati; Beebe, Stephen; Roman-Paoli, Elvin; Gonzalez, Abiezer; Beaver, James; Ricaurte, Jaumer; Colbert, Raphael; Correll, Melanie J

    2017-05-01

    This work reports the effects of the genetic makeup, the environment and the genotype by environment interactions for node addition rate in an RIL population of common bean. This information was used to build a predictive model for node addition rate. To select a plant genotype that will thrive in targeted environments it is critical to understand the genotype by environment interaction (GEI). In this study, multi-environment QTL analysis was used to characterize node addition rate (NAR, node day(- 1)) on the main stem of the common bean (Phaseolus vulgaris L). This analysis was carried out with field data of 171 recombinant inbred lines that were grown at five sites (Florida, Puerto Rico, 2 sites in Colombia, and North Dakota). Four QTLs (Nar1, Nar2, Nar3 and Nar4) were identified, one of which had significant QTL by environment interactions (QEI), that is, Nar2 with temperature. Temperature was identified as the main environmental factor affecting NAR while day length and solar radiation played a minor role. Integration of sites as covariates into a QTL mixed site-effect model, and further replacing the site component with explanatory environmental covariates (i.e., temperature, day length and solar radiation) yielded a model that explained 73% of the phenotypic variation for NAR with root mean square error of 16.25% of the mean. The QTL consistency and stability was examined through a tenfold cross validation with different sets of genotypes and these four QTLs were always detected with 50-90% probability. The final model was evaluated using leave-one-site-out method to assess the influence of site on node addition rate. These analyses provided a quantitative measure of the effects on NAR of common beans exerted by the genetic makeup, the environment and their interactions.

  10. Mathematical modeling of polyphenolic additive made from grape stone with for meet products

    Directory of Open Access Journals (Sweden)

    Інна Олександрівна Літвінова

    2015-07-01

    Full Text Available In the article the optimal parameters are defined to obtain polyphenol additive made from grape stone of antioxidant purpose – "Maltovyn" by the method of mathematical planning of multifactor experiments. Research is conducted under the matrix of D-quadratic optimal plan of experiments. The results of microwave extraction process of phenolic compounds with maximum antioxidant activity are obtained. It was established that the selected model provides a set of detection values that minimize divergence of calculated and experimental data

  11. Clarifying the use of aggregated exposures in multilevel models: self-included vs. self-excluded measures.

    Directory of Open Access Journals (Sweden)

    Etsuji Suzuki

    Full Text Available BACKGROUND: Multilevel analyses are ideally suited to assess the effects of ecological (higher level and individual (lower level exposure variables simultaneously. In applying such analyses to measures of ecologies in epidemiological studies, individual variables are usually aggregated into the higher level unit. Typically, the aggregated measure includes responses of every individual belonging to that group (i.e. it constitutes a self-included measure. More recently, researchers have developed an aggregate measure which excludes the response of the individual to whom the aggregate measure is linked (i.e. a self-excluded measure. In this study, we clarify the substantive and technical properties of these two measures when they are used as exposures in multilevel models. METHODS: Although the differences between the two aggregated measures are mathematically subtle, distinguishing between them is important in terms of the specific scientific questions to be addressed. We then show how these measures can be used in two distinct types of multilevel models-self-included model and self-excluded model-and interpret the parameters in each model by imposing hypothetical interventions. The concept is tested on empirical data of workplace social capital and employees' systolic blood pressure. RESULTS: Researchers assume group-level interventions when using a self-included model, and individual-level interventions when using a self-excluded model. Analytical re-parameterizations of these two models highlight their differences in parameter interpretation. Cluster-mean centered self-included models enable researchers to decompose the collective effect into its within- and between-group components. The benefit of cluster-mean centering procedure is further discussed in terms of hypothetical interventions. CONCLUSIONS: When investigating the potential roles of aggregated variables, researchers should carefully explore which type of model-self-included or self

  12. A gamma variate model that includes stretched exponential is a better fit for gastric emptying data from mice.

    Science.gov (United States)

    Bajzer, Željko; Gibbons, Simon J; Coleman, Heidi D; Linden, David R; Farrugia, Gianrico

    2015-08-01

    Noninvasive breath tests for gastric emptying are important techniques for understanding the changes in gastric motility that occur in disease or in response to drugs. Mice are often used as an animal model; however, the gamma variate model currently used for data analysis does not always fit the data appropriately. The aim of this study was to determine appropriate mathematical models to better fit mouse gastric emptying data including when two peaks are present in the gastric emptying curve. We fitted 175 gastric emptying data sets with two standard models (gamma variate and power exponential), with a gamma variate model that includes stretched exponential and with a proposed two-component model. The appropriateness of the fit was assessed by the Akaike Information Criterion. We found that extension of the gamma variate model to include a stretched exponential improves the fit, which allows for a better estimation of T1/2 and Tlag. When two distinct peaks in gastric emptying are present, a two-component model is required for the most appropriate fit. We conclude that use of a stretched exponential gamma variate model and when appropriate a two-component model will result in a better estimate of physiologically relevant parameters when analyzing mouse gastric emptying data.

  13. Rain water transport and storage in a model sandy soil with hydrogel particle additives.

    Science.gov (United States)

    Wei, Y; Durian, D J

    2014-10-01

    We study rain water infiltration and drainage in a dry model sandy soil with superabsorbent hydrogel particle additives by measuring the mass of retained water for non-ponding rainfall using a self-built 3D laboratory set-up. In the pure model sandy soil, the retained water curve measurements indicate that instead of a stable horizontal wetting front that grows downward uniformly, a narrow fingered flow forms under the top layer of water-saturated soil. This rain water channelization phenomenon not only further reduces the available rain water in the plant root zone, but also affects the efficiency of soil additives, such as superabsorbent hydrogel particles. Our studies show that the shape of the retained water curve for a soil packing with hydrogel particle additives strongly depends on the location and the concentration of the hydrogel particles in the model sandy soil. By carefully choosing the particle size and distribution methods, we may use the swollen hydrogel particles to modify the soil pore structure, to clog or extend the water channels in sandy soils, or to build water reservoirs in the plant root zone.

  14. Including the effects of filamentous bulking sludge during the simulation of wastewater treatment plants using a risk assessment model

    DEFF Research Database (Denmark)

    Flores Alsina, Xavier; Comas, J.; Rodriquez-Roda, I.

    2009-01-01

    The main objective of this paper is to demonstrate how including the occurrence of filamentous bulking sludge in a secondary clarifier model will affect the predicted process performance during the simulation of WWTPs. The IWA Benchmark Simulation Model No. 2 (BSM2) is hereby used as a simulation...

  15. The selection and use of essential medicines. Report of the WHO Expert Committee, 2002 (including the 12th Model list of essential medicines).

    Science.gov (United States)

    2003-01-01

    This report presents the recommendations of the WHO Expert Committee responsible for updating the WHO Model List of Essential Medicines. The first part contains a progress report on the new procedures for updating the Model List and the development of the WHO Essential Medicines Library. It continues to present a summary of the Committee's considerations and justifications for additions and changes to the Model List, including its recommendation to add 12 antiretroviral medicines. Annexes to the main report include the revised version of the WHO Model List of Essential Medicines (the 12th) and, for the first time, a list of all items on the Model List sorted according to their 5-level Anatomical Therapeutic Chemical (ATC) classification codes.

  16. Dynamic modeling for rigid rotor bearing systems with a localized defect considering additional deformations at the sharp edges

    Science.gov (United States)

    Liu, Jing; Shao, Yimin

    2017-06-01

    Rotor bearing systems (RBSs) play a very valuable role for wind turbine gearboxes, aero-engines, high speed spindles, and other rotational machinery. An in-depth understanding of vibrations of the RBSs is very useful for condition monitoring and diagnosis applications of these machines. A new twelve-degree-of-freedom dynamic model for rigid RBSs with a localized defect (LOD) is proposed. This model can formulate the housing support stiffness, interfacial frictional moments including load dependent and load independent components, time-varying displacement excitation caused by a LOD, additional deformations at the sharp edges of the LOD, and lubricating oil film. The time-varying displacement model is determined by a half-sine function. A new method for calculating the additional deformations at the sharp edges of the LOD is analytical derived based on an elastic quarter-space method presented in the literature. The proposed dynamic model is utilized to analyze the influences of the housing support stiffness and LOD sizes on the vibration characteristics of the rigid RBS, which cannot be predicted by the previous dynamic models in the literature. The results show that the presented method can give a new dynamic modeling method for vibration formulation for a rigid RBS with and without the LOD on the races.

  17. GenoGAM: genome-wide generalized additive models for ChIP-Seq analysis.

    Science.gov (United States)

    Stricker, Georg; Engelhardt, Alexander; Schulz, Daniel; Schmid, Matthias; Tresch, Achim; Gagneur, Julien

    2017-08-01

    Chromatin immunoprecipitation followed by deep sequencing (ChIP-Seq) is a widely used approach to study protein-DNA interactions. Often, the quantities of interest are the differential occupancies relative to controls, between genetic backgrounds, treatments, or combinations thereof. Current methods for differential occupancy of ChIP-Seq data rely however on binning or sliding window techniques, for which the choice of the window and bin sizes are subjective. Here, we present GenoGAM (Genome-wide Generalized Additive Model), which brings the well-established and flexible generalized additive models framework to genomic applications using a data parallelism strategy. We model ChIP-Seq read count frequencies as products of smooth functions along chromosomes. Smoothing parameters are objectively estimated from the data by cross-validation, eliminating ad hoc binning and windowing needed by current approaches. GenoGAM provides base-level and region-level significance testing for full factorial designs. Application to a ChIP-Seq dataset in yeast showed increased sensitivity over existing differential occupancy methods while controlling for type I error rate. By analyzing a set of DNA methylation data and illustrating an extension to a peak caller, we further demonstrate the potential of GenoGAM as a generic statistical modeling tool for genome-wide assays. Software is available from Bioconductor: https://www.bioconductor.org/packages/release/bioc/html/GenoGAM.html . gagneur@in.tum.de. Supplementary information is available at Bioinformatics online.

  18. IGE Model: An Extension of the Ideal Gas Model to Include Chemical Composition as Part of the Equilibrium State

    Directory of Open Access Journals (Sweden)

    Christopher P. Paolini

    2012-01-01

    Full Text Available The ideal gas (IG model is probably the most well-known gas models in engineering thermodynamics. In this paper, we extend the IG model into an ideal gas equilibrium (IGE model mixture model by incorporating chemical equilibrium calculations as part of the state evaluation. Through a simple graphical interface, users can set the atomic composition of a gas mixture. We have integrated this model into a thermodynamic web portal TEST (http://thermofluids.sdsu.edu/ that contains Java applets for various models for properties of pure substances. In the state panel of the IGE model, the known thermodynamic properties are entered. For a given pressure and temperature, the mixture's Gibbs function is minimized subject to atomic constraints and the equilibrium composition along with thermodynamic properties of the mixture are calculated and displayed. What is unique about this approach is that equilibrium computations are performed in the background, without requiring any major change in the familiar user interface used in other state daemons. Properties calculated by this equilibrium state daemon are compared with results from other established applications such as NASA CEA and STANJAN. Also, two different algorithms, an iterative approach and a direct approach based on minimizing different thermodynamic functions in different situation, are compared.

  19. OBLIMAP 2.0 : A fast climate model-ice sheet model coupler including online embeddable mapping routines

    NARCIS (Netherlands)

    Reerink, Thomas J.; Jan Van De Berg, Willem; Van De Wal, Roderik S W

    2016-01-01

    This paper accompanies the second OBLIMAP open-source release. The package is developed to map climate fields between a general circulation model (GCM) and an ice sheet model (ISM) in both directions by using optimal aligned oblique projections, which minimize distortions. The curvature of the surfa

  20. An Asset Pricing Approach to Testing General Term Structure Models including Heath-Jarrow-Morton Specifications and Affine Subclasses

    DEFF Research Database (Denmark)

    Christensen, Bent Jesper; van der Wel, Michel

    of the risk premium is associated with the slope factor, and individual risk prices depend on own past values, factor realizations, and past values of other risk prices, and are significantly related to the output gap, consumption, and the equity risk price. The absence of arbitrage opportunities is strongly...... is tested, but in addition to the standard bilinear term in factor loadings and market prices of risk, the relevant mean restriction in the term structure case involves an additional nonlinear (quadratic) term in factor loadings. We estimate our general model using likelihood-based dynamic factor model...... techniques for a variety of volatility factors, and implement the relevant likelihood ratio tests. Our factor model estimates are similar across a general state space implementation and an alternative robust two-step principal components approach. The evidence favors time-varying market prices of risk. Most...

  1. Reduction of carcinogenic 4(5)-methylimidazole in a caramel model system: influence of food additives.

    Science.gov (United States)

    Seo, Seulgi; Ka, Mi-Hyun; Lee, Kwang-Geun

    2014-07-09

    The effect of various food additives on the formation of carcinogenic 4(5)-methylimidazole (4-MI) in a caramel model system was investigated. The relationship between the levels of 4-MI and various pyrazines was studied. When glucose and ammonium hydroxide were heated, the amount of 4-MI was 556 ± 1.3 μg/mL, which increased to 583 ± 2.6 μg/mL by the addition of 0.1 M of sodium sulfite. When various food additives, such as 0.1 M of iron sulfate, magnesium sulfate, zinc sulfate, tryptophan, and cysteine were added, the amount of 4-MI was reduced to 110 ± 0.7, 483 ± 2.0, 460 ± 2.0, 409 ± 4.4, and 397 ± 1.7 μg/mL, respectively. The greatest reduction, 80%, occurred with the addition of iron sulfate. Among the 12 pyrazines, 2-ethyl-6-methylpyrazine with 4-MI showed the highest correlation (r = -0.8239).

  2. Addition of devolatilization equations to synthane computerized mathematical model. Quarterly report, September 15--December 15, 1978

    Energy Technology Data Exchange (ETDEWEB)

    Cobb, J.T. Jr.

    1979-01-01

    Six approaches to devolatilization modeling have been reviewed. Two have been selected for further evaluation: the Vand-type model of Anthony and Howard and the diffusion model of Russel et al. The first of these treats particles under kinetic control only. The second includes some mass transfer control along with kinetic control. Behavior of particles in the SYNTHANE process appears to be in the transition region between kinetic and mass transfer control. Work during the next quarter will focus on the temperature history of average particles in the carbonizer of the SYNTHANE process and on the methods by which the two devolatilization models chosen will be used to describe conversion in the SYNTHANE carbonizer.

  3. The Benefits of Including Clinical Factors in Rectal Normal Tissue Complication Probability Modeling After Radiotherapy for Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Defraene, Gilles, E-mail: gilles.defraene@uzleuven.be [Radiation Oncology Department, University Hospitals Leuven, Leuven (Belgium); Van den Bergh, Laura [Radiation Oncology Department, University Hospitals Leuven, Leuven (Belgium); Al-Mamgani, Abrahim [Department of Radiation Oncology, Erasmus Medical Center - Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Haustermans, Karin [Radiation Oncology Department, University Hospitals Leuven, Leuven (Belgium); Heemsbergen, Wilma [Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Van den Heuvel, Frank [Radiation Oncology Department, University Hospitals Leuven, Leuven (Belgium); Lebesque, Joos V. [Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)

    2012-03-01

    Purpose: To study the impact of clinical predisposing factors on rectal normal tissue complication probability modeling using the updated results of the Dutch prostate dose-escalation trial. Methods and Materials: Toxicity data of 512 patients (conformally treated to 68 Gy [n = 284] and 78 Gy [n = 228]) with complete follow-up at 3 years after radiotherapy were studied. Scored end points were rectal bleeding, high stool frequency, and fecal incontinence. Two traditional dose-based models (Lyman-Kutcher-Burman (LKB) and Relative Seriality (RS) and a logistic model were fitted using a maximum likelihood approach. Furthermore, these model fits were improved by including the most significant clinical factors. The area under the receiver operating characteristic curve (AUC) was used to compare the discriminating ability of all fits. Results: Including clinical factors significantly increased the predictive power of the models for all end points. In the optimal LKB, RS, and logistic models for rectal bleeding and fecal incontinence, the first significant (p = 0.011-0.013) clinical factor was 'previous abdominal surgery.' As second significant (p = 0.012-0.016) factor, 'cardiac history' was included in all three rectal bleeding fits, whereas including 'diabetes' was significant (p = 0.039-0.048) in fecal incontinence modeling but only in the LKB and logistic models. High stool frequency fits only benefitted significantly (p = 0.003-0.006) from the inclusion of the baseline toxicity score. For all models rectal bleeding fits had the highest AUC (0.77) where it was 0.63 and 0.68 for high stool frequency and fecal incontinence, respectively. LKB and logistic model fits resulted in similar values for the volume parameter. The steepness parameter was somewhat higher in the logistic model, also resulting in a slightly lower D{sub 50}. Anal wall DVHs were used for fecal incontinence, whereas anorectal wall dose best described the other two endpoints

  4. Minimax-optimal rates for sparse additive models over kernel classes via convex programming

    CERN Document Server

    Raskutti, Garvesh; Yu, Bin

    2010-01-01

    Sparse additive models are families of $d$-variate functions that have the additive decomposition \\mbox{$f^* = \\sum_{j \\in S} f^*_j$,} where $S$ is a unknown subset of cardinality $s \\ll d$. We consider the case where each component function $f^*_j$ lies in a reproducing kernel Hilbert space, and analyze a simple kernel-based convex program for estimating the unknown function $f^*$. Working within a high-dimensional framework that allows both the dimension $d$ and sparsity $s$ to scale, we derive convergence rates in the $L^2(\\mathbb{P})$ and $L^2(\\mathbb{P}_n)$ norms. These rates consist of two terms: a \\emph{subset selection term} of the order $\\frac{s \\log d}{n}$, corresponding to the difficulty of finding the unknown $s$-sized subset, and an \\emph{estimation error} term of the order $s \\, \

  5. Utilization of sulfate additives in biomass combustion: fundamental and modeling aspects

    DEFF Research Database (Denmark)

    Wu, Hao; Jespersen, Jacob Boll; Grell, Morten Nedergaard;

    2013-01-01

    Sulfates, such as ammonium sulfate, aluminum sulfate and ferric sulfate, are effective additives for converting the alkali chlorides released from biomass combustion to the less harmful alkali sulfates. Optimization of the use of these additives requires knowledge on their decomposition rate...... and product distribution under high temperature conditions. In the present work, the decomposition of ammonium sulfate, aluminum sulfate and ferric sulfate was studied respectively in a fast-heating rate thermogravimetric analyzer for deriving a kinetic model to describe the process. The yields of SO2 and SO3...... of different sulfates indicated that ammonium sulfate has clearly strongest sulfation power towards KCl at temperatures below 800oC, whereas the sulfation power of ferric and aluminum sulfates exceeds clearly that of ammonium sulfate between 900 and 1000oC. However, feeding gaseous SO3 was found to be most...

  6. Analysis of time to event outcomes in randomized controlled trials by generalized additive models.

    Directory of Open Access Journals (Sweden)

    Christos Argyropoulos

    Full Text Available Randomized Controlled Trials almost invariably utilize the hazard ratio calculated with a Cox proportional hazard model as a treatment efficacy measure. Despite the widespread adoption of HRs, these provide a limited understanding of the treatment effect and may even provide a biased estimate when the assumption of proportional hazards in the Cox model is not verified by the trial data. Additional treatment effect measures on the survival probability or the time scale may be used to supplement HRs but a framework for the simultaneous generation of these measures is lacking.By splitting follow-up time at the nodes of a Gauss Lobatto numerical quadrature rule, techniques for Poisson Generalized Additive Models (PGAM can be adopted for flexible hazard modeling. Straightforward simulation post-estimation transforms PGAM estimates for the log hazard into estimates of the survival function. These in turn were used to calculate relative and absolute risks or even differences in restricted mean survival time between treatment arms. We illustrate our approach with extensive simulations and in two trials: IPASS (in which the proportionality of hazards was violated and HEMO a long duration study conducted under evolving standards of care on a heterogeneous patient population.PGAM can generate estimates of the survival function and the hazard ratio that are essentially identical to those obtained by Kaplan Meier curve analysis and the Cox model. PGAMs can simultaneously provide multiple measures of treatment efficacy after a single data pass. Furthermore, supported unadjusted (overall treatment effect but also subgroup and adjusted analyses, while incorporating multiple time scales and accounting for non-proportional hazards in survival data.By augmenting the HR conventionally reported, PGAMs have the potential to support the inferential goals of multiple stakeholders involved in the evaluation and appraisal of clinical trial results under proportional and

  7. Topsoil organic carbon content of Europe, a new map based on a generalised additive model

    Science.gov (United States)

    de Brogniez, Delphine; Ballabio, Cristiano; Stevens, Antoine; Jones, Robert J. A.; Montanarella, Luca; van Wesemael, Bas

    2014-05-01

    There is an increasing demand for up-to-date spatially continuous organic carbon (OC) data for global environment and climatic modeling. Whilst the current map of topsoil organic carbon content for Europe (Jones et al., 2005) was produced by applying expert-knowledge based pedo-transfer rules on large soil mapping units, the aim of this study was to replace it by applying digital soil mapping techniques on the first European harmonised geo-referenced topsoil (0-20 cm) database, which arises from the LUCAS (land use/cover area frame statistical survey) survey. A generalized additive model (GAM) was calibrated on 85% of the dataset (ca. 17 000 soil samples) and a backward stepwise approach selected slope, land cover, temperature, net primary productivity, latitude and longitude as environmental covariates (500 m resolution). The validation of the model (applied on 15% of the dataset), gave an R2 of 0.27. We observed that most organic soils were under-predicted by the model and that soils of Scandinavia were also poorly predicted. The model showed an RMSE of 42 g kg-1 for mineral soils and of 287 g kg-1 for organic soils. The map of predicted OC content showed the lowest values in Mediterranean countries and in croplands across Europe, whereas highest OC content were predicted in wetlands, woodlands and in mountainous areas. The map of standard error of the OC model predictions showed high values in northern latitudes, wetlands, moors and heathlands, whereas low uncertainty was mostly found in croplands. A comparison of our results with the map of Jones et al. (2005) showed a general agreement on the prediction of mineral soils' OC content, most probably because the models use some common covariates, namely land cover and temperature. Our model however failed to predict values of OC content greater than 200 g kg-1, which we explain by the imposed unimodal distribution of our model, whose mean is tilted towards the majority of soils, which are mineral. Finally, average

  8. Improving the predictive accuracy of hurricane power outage forecasts using generalized additive models.

    Science.gov (United States)

    Han, Seung-Ryong; Guikema, Seth D; Quiring, Steven M

    2009-10-01

    Electric power is a critical infrastructure service after hurricanes, and rapid restoration of electric power is important in order to minimize losses in the impacted areas. However, rapid restoration of electric power after a hurricane depends on obtaining the necessary resources, primarily repair crews and materials, before the hurricane makes landfall and then appropriately deploying these resources as soon as possible after the hurricane. This, in turn, depends on having sound estimates of both the overall severity of the storm and the relative risk of power outages in different areas. Past studies have developed statistical, regression-based approaches for estimating the number of power outages in advance of an approaching hurricane. However, these approaches have either not been applicable for future events or have had lower predictive accuracy than desired. This article shows that a different type of regression model, a generalized additive model (GAM), can outperform the types of models used previously. This is done by developing and validating a GAM based on power outage data during past hurricanes in the Gulf Coast region and comparing the results from this model to the previously used generalized linear models.

  9. Analysis of two-phase sampling data with semiparametric additive hazards models.

    Science.gov (United States)

    Sun, Yanqing; Qian, Xiyuan; Shou, Qiong; Gilbert, Peter B

    2017-07-01

    Under the case-cohort design introduced by Prentice (Biometrica 73:1-11, 1986), the covariate histories are ascertained only for the subjects who experience the event of interest (i.e., the cases) during the follow-up period and for a relatively small random sample from the original cohort (i.e., the subcohort). The case-cohort design has been widely used in clinical and epidemiological studies to assess the effects of covariates on failure times. Most statistical methods developed for the case-cohort design use the proportional hazards model, and few methods allow for time-varying regression coefficients. In addition, most methods disregard data from subjects outside of the subcohort, which can result in inefficient inference. Addressing these issues, this paper proposes an estimation procedure for the semiparametric additive hazards model with case-cohort/two-phase sampling data, allowing the covariates of interest to be missing for cases as well as for non-cases. A more flexible form of the additive model is considered that allows the effects of some covariates to be time varying while specifying the effects of others to be constant. An augmented inverse probability weighted estimation procedure is proposed. The proposed method allows utilizing the auxiliary information that correlates with the phase-two covariates to improve efficiency. The asymptotic properties of the proposed estimators are established. An extensive simulation study shows that the augmented inverse probability weighted estimation is more efficient than the widely adopted inverse probability weighted complete-case estimation method. The method is applied to analyze data from a preventive HIV vaccine efficacy trial.

  10. Mixed butanols addition to gasoline surrogates: Shock tube ignition delay time measurements and chemical kinetic modeling

    KAUST Repository

    AlRamadan, Abdullah S.

    2015-10-01

    The demand for fuels with high anti-knock quality has historically been rising, and will continue to increase with the development of downsized and turbocharged spark-ignition engines. Butanol isomers, such as 2-butanol and tert-butanol, have high octane ratings (RON of 105 and 107, respectively), and thus mixed butanols (68.8% by volume of 2-butanol and 31.2% by volume of tert-butanol) can be added to the conventional petroleum-derived gasoline fuels to improve octane performance. In the present work, the effect of mixed butanols addition to gasoline surrogates has been investigated in a high-pressure shock tube facility. The ignition delay times of mixed butanols stoichiometric mixtures were measured at 20 and 40bar over a temperature range of 800-1200K. Next, 10vol% and 20vol% of mixed butanols (MB) were blended with two different toluene/n-heptane/iso-octane (TPRF) fuel blends having octane ratings of RON 90/MON 81.7 and RON 84.6/MON 79.3. These MB/TPRF mixtures were investigated in the shock tube conditions similar to those mentioned above. A chemical kinetic model was developed to simulate the low- and high-temperature oxidation of mixed butanols and MB/TPRF blends. The proposed model is in good agreement with the experimental data with some deviations at low temperatures. The effect of mixed butanols addition to TPRFs is marginal when examining the ignition delay times at high temperatures. However, when extended to lower temperatures (T < 850K), the model shows that the mixed butanols addition to TPRFs causes the ignition delay times to increase and hence behaves like an octane booster at engine-like conditions. © 2015 The Combustion Institute.

  11. Micellar Effects on Nucleophilic Addition Reaction and Applicability of Enzyme Catalysis Model

    Directory of Open Access Journals (Sweden)

    R. K. London Singh

    2012-01-01

    Full Text Available This study describes the effect of anionic and cationic micelles on nucleophilic addition reaction of rosaniline hydrochloride (RH with hydroxide under pseudo-first order condition. Strong inhibitory effect is observed due to SDS micelle, whereas CTAB catalysed the reaction. This is explained on the basis of electrostatic and hydrophobic interactions which are simultaneously operating in the reaction system. The kinetic data obtained is quantitatively analysed by applying the positive cooperativity model of enzyme catalysis. Binding constants and influence of counterions on the reaction have also been investigated.

  12. An Empirical Research on the Model of the Right in Additional Allocation of Stocks

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    How to define the value of the Right in Additional Al location of Stocks (RAAS) acts an important role in stock markets whether or not the shareholders execute the right. Moreover, the valuation defining of RAAS an d the exercise price (K) are mutual cause and effect. Based on some literatures on this subject, this paper presents a model valuing the RAAS per-share. With t he opening information in ShenZheng Stock Markets, we make a simulation on the R AAS's value of shenwuye, which is a shareholding corp...

  13. A mechanistic model of infection: why duration and intensity of contacts should be included in models of disease spread

    Directory of Open Access Journals (Sweden)

    Smieszek Timo

    2009-11-01

    Full Text Available Abstract Background Mathematical models and simulations of disease spread often assume a constant per-contact transmission probability. This assumption ignores the heterogeneity in transmission probabilities, e.g. due to the varying intensity and duration of potentially contagious contacts. Ignoring such heterogeneities might lead to erroneous conclusions from simulation results. In this paper, we show how a mechanistic model of disease transmission differs from this commonly used assumption of a constant per-contact transmission probability. Methods We present an exposure-based, mechanistic model of disease transmission that reflects heterogeneities in contact duration and intensity. Based on empirical contact data, we calculate the expected number of secondary cases induced by an infector (i for the mechanistic model and (ii under the classical assumption of a constant per-contact transmission probability. The results of both approaches are compared for different basic reproduction numbers R0. Results The outcomes of the mechanistic model differ significantly from those of the assumption of a constant per-contact transmission probability. In particular, cases with many different contacts have much lower expected numbers of secondary cases when using the mechanistic model instead of the common assumption. This is due to the fact that the proportion of long, intensive contacts decreases in the contact dataset with an increasing total number of contacts. Conclusion The importance of highly connected individuals, so-called super-spreaders, for disease spread seems to be overestimated when a constant per-contact transmission probability is assumed. This holds particularly for diseases with low basic reproduction numbers. Simulations of disease spread should weight contacts by duration and intensity.

  14. Mathematical Model of Two Phase Flow in Natural Draft Wet-Cooling Tower Including Flue Gas Injection

    Directory of Open Access Journals (Sweden)

    Hyhlík Tomáš

    2016-01-01

    Full Text Available The previously developed model of natural draft wet-cooling tower flow, heat and mass transfer is extended to be able to take into account the flow of supersaturated moist air. The two phase flow model is based on void fraction of gas phase which is included in the governing equations. Homogeneous equilibrium model, where the two phases are well mixed and have the same velocity, is used. The effect of flue gas injection is included into the developed mathematical model by using source terms in governing equations and by using momentum flux coefficient and kinetic energy flux coefficient. Heat and mass transfer in the fill zone is described by the system of ordinary differential equations, where the mass transfer is represented by measured fill Merkel number and heat transfer is calculated using prescribed Lewis factor.

  15. Hybrid 2D-3D modelling of GTA welding with filler wire addition

    KAUST Repository

    Traidia, Abderrazak

    2012-07-01

    A hybrid 2D-3D model for the numerical simulation of Gas Tungsten Arc welding is proposed in this paper. It offers the possibility to predict the temperature field as well as the shape of the solidified weld joint for different operating parameters, with relatively good accuracy and reasonable computational cost. Also, an original approach to simulate the effect of immersing a cold filler wire in the weld pool is presented. The simulation results reveal two important observations. First, the weld pool depth is locally decreased in the presence of filler metal, which is due to the energy absorption by the cold feeding wire from the hot molten pool. In addition, the weld shape, maximum temperature and thermal cycles in the workpiece are relatively well predicted even when a 2D model for the arc plasma region is used. © 2012 Elsevier Ltd. All rights reserved.

  16. Generalized additive models and Lucilia sericata growth: assessing confidence intervals and error rates in forensic entomology.

    Science.gov (United States)

    Tarone, Aaron M; Foran, David R

    2008-07-01

    Forensic entomologists use blow fly development to estimate a postmortem interval. Although accurate, fly age estimates can be imprecise for older developmental stages and no standard means of assigning confidence intervals exists. Presented here is a method for modeling growth of the forensically important blow fly Lucilia sericata, using generalized additive models (GAMs). Eighteen GAMs were created to predict the extent of juvenile fly development, encompassing developmental stage, length, weight, strain, and temperature data, collected from 2559 individuals. All measures were informative, explaining up to 92.6% of the deviance in the data, though strain and temperature exerted negligible influences. Predictions made with an independent data set allowed for a subsequent examination of error. Estimates using length and developmental stage were within 5% of true development percent during the feeding portion of the larval life cycle, while predictions for postfeeding third instars were less precise, but within expected error.

  17. On adjustment for auxiliary covariates in additive hazard models for the analysis of randomized experiments

    DEFF Research Database (Denmark)

    Vansteelandt, S.; Martinussen, Torben; Tchetgen, E. J Tchetgen

    2014-01-01

    's dependence on time or on the auxiliary covariates is misspecified, and even away from the null hypothesis of no treatment effect. We furthermore show that adjustment for auxiliary baseline covariates does not change the asymptotic variance of the estimator of the effect of a randomized treatment. We conclude......We consider additive hazard models (Aalen, 1989) for the effect of a randomized treatment on a survival outcome, adjusting for auxiliary baseline covariates. We demonstrate that the Aalen least-squares estimator of the treatment effect parameter is asymptotically unbiased, even when the hazard...... that, in view of its robustness against model misspecification, Aalen least-squares estimation is attractive for evaluating treatment effects on a survival outcome in randomized experiments, and the primary reasons to consider baseline covariate adjustment in such settings could be interest in subgroup...

  18. Dynamic Behavior of Artificial Hodgkin-Huxley Neuron Model Subject to Additive Noise.

    Science.gov (United States)

    Kang, Qi; Huang, BingYao; Zhou, MengChu

    2016-09-01

    Motivated by neuroscience discoveries during the last few years, many studies consider pulse-coupled neural networks with spike-timing as an essential component in information processing by the brain. There also exists some technical challenges while simulating