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Sample records for modeling study evaluated

  1. QUALITY OF AN ACADEMIC STUDY PROGRAMME - EVALUATION MODEL

    Directory of Open Access Journals (Sweden)

    Mirna Macur

    2016-01-01

    Full Text Available Quality of an academic study programme is evaluated by many: employees (internal evaluation and by external evaluators: experts, agencies and organisations. Internal and external evaluation of an academic programme follow written structure that resembles on one of the quality models. We believe the quality models (mostly derived from EFQM excellence model don’t fit very well into non-profit activities, policies and programmes, because they are much more complex than environment, from which quality models derive from (for example assembly line. Quality of an academic study programme is very complex and understood differently by various stakeholders, so we present dimensional evaluation in the article. Dimensional evaluation, as opposed to component and holistic evaluation, is a form of analytical evaluation in which the quality of value of the evaluand is determined by looking at its performance on multiple dimensions of merit or evaluation criteria. First stakeholders of a study programme and their views, expectations and interests are presented, followed by evaluation criteria. They are both joined into the evaluation model revealing which evaluation criteria can and should be evaluated by which stakeholder. Main research questions are posed and research method for each dimension listed.

  2. Study of Purchase Process Modeling and Reengineering Effects Evaluation

    Institute of Scientific and Technical Information of China (English)

    ZhenhuanJiang; LiangQuan; PeiwuDong

    2004-01-01

    Purchase process is an important part in the process of running an enterprise.For reengineering the process of'enterprise, raise business efficiency of enterprise , make enterprise competitive among complicated and changeable market environment. Use the method of planning to evaluate the technology modeling and method to set up evaluation index, based on the basic principle business process reengineering, studied the methods of modeling and evaluating of the reengineering of the purchase process. Given the intact method of modeling process. Give the mathematics express method and figure express method of the process, propose using PT reducing rate to evaluate the effect of the process reengineer, and has analysed three kinds of situations that affect the reducing rate of PT.

  3. Study on Turbulent Modeling in Gas Entrainment Evaluation Method

    Science.gov (United States)

    Ito, Kei; Ohshima, Hiroyuki; Nakamine, Yoshiaki; Imai, Yasutomo

    Suppression of gas entrainment (GE) phenomena caused by free surface vortices are very important to establish an economically superior design of the sodium-cooled fast reactor in Japan (JSFR). However, due to the non-linearity and/or locality of the GE phenomena, it is not easy to evaluate the occurrences of the GE phenomena accurately. In other words, the onset condition of the GE phenomena in the JSFR is not predicted easily based on scaled-model and/or partial-model experiments. Therefore, the authors are developing a CFD-based evaluation method in which the non-linearity and locality of the GE phenomena can be considered. In the evaluation method, macroscopic vortex parameters, e.g. circulation, are determined by three-dimensional CFD and then, GE-related parameters, e.g. gas core (GC) length, are calculated by using the Burgers vortex model. This procedure is efficient to evaluate the GE phenomena in the JSFR. However, it is well known that the Burgers vortex model tends to overestimate the GC length due to the lack of considerations on some physical mechanisms. Therefore, in this study, the authors develop a turbulent vortex model to evaluate the GE phenomena more accurately. Then, the improved GE evaluation method with the turbulent viscosity model is validated by analyzing the GC lengths observed in a simple experiment. The evaluation results show that the GC lengths analyzed by the improved method are shorter in comparison to the original method, and give better agreement with the experimental data.

  4. An updated summary of MATHEW/ADPIC model evaluation studies

    Energy Technology Data Exchange (ETDEWEB)

    Foster, K.T.; Dickerson, M.H.

    1990-05-01

    This paper summarizes the major model evaluation studies conducted for the MATHEW/ADPIC atmospheric transport and diffusion models used by the US Department of Energy's Atmospheric Release Advisory Capability. These studies have taken place over the last 15 years and involve field tracer releases influenced by a variety of meteorological and topographical conditions. Neutrally buoyant tracers released both as surface and elevated point sources, as well as material dispersed by explosive, thermally bouyant release mechanisms have been studied. Results from these studies show that the MATHEW/ADPIC models estimate the tracer air concentrations to within a factor of two of the measured values 20% to 50% of the time, and within a factor of five of the measurements 35% to 85% of the time depending on the complexity of the meteorology and terrain, and the release height of the tracer. Comparisons of model estimates to peak downwind deposition and air concentration measurements from explosive releases are shown to be generally within a factor of two to three. 24 refs., 14 figs., 3 tabs.

  5. Study and Application of Objective Evaluation Model on Fabric Style

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Based on 31 fabric property parameters tested by FAST test system and other test instruments, the principal factors of fabric style are obtained through the principal factor analysis method and computer program. According to the correlation between each parameter and principal factor,the selected positive or negative coefficient, the objective evaluation model of fabric style bas been established based on the percentage of variance. And wool fabrics have been taken for example to show how to use the objective evaluation model for fabric design.

  6. A case study in modeling a nuclear formation evaluation sub

    Energy Technology Data Exchange (ETDEWEB)

    Locke, S. (Teleco Oilfield Services, Inc., Middletown, CT (United States))

    1992-08-01

    This paper reports that constructing an accurate Monte Carlo representation of a complex nuclear formation evaluation tool requires careful matching of computed values to the results of laboratory experiments. The availability of only finite computing resources forces restraint in the step by step addition of complexity to the model. Once confidence in the model has been established, it can be used to predict tool response to many situations not reproducible in a laboratory. High temperatures, high pressures, and pore fluids composed of liquid-gas mixtures are typical of conditions encountered in real oil wells that are difficult to reproduce in a laboratory. Tool design and the effects of design modifications can also be evaluated efficiently using the model.

  7. Evaluating EML Modeling Tools for Insurance Purposes: A Case Study

    Directory of Open Access Journals (Sweden)

    Mikael Gustavsson

    2010-01-01

    Full Text Available As with any situation that involves economical risk refineries may share their risk with insurers. The decision process generally includes modelling to determine to which extent the process area can be damaged. On the extreme end of modelling the so-called Estimated Maximum Loss (EML scenarios are found. These scenarios predict the maximum loss a particular installation can sustain. Unfortunately no standard model for this exists. Thus the insurers reach different results due to applying different models and different assumptions. Therefore, a study has been conducted on a case in a Swedish refinery where several scenarios previously had been modelled by two different insurance brokers using two different softwares, ExTool and SLAM. This study reviews the concept of EML and analyses the used models to see which parameters are most uncertain. Also a third model, EFFECTS, was employed in an attempt to reach a conclusion with higher reliability.

  8. Looking beyond general metrics for model evaluation - lessons from an international model intercomparison study

    Science.gov (United States)

    Bouaziz, Laurène; de Boer-Euser, Tanja; Brauer, Claudia; Drogue, Gilles; Fenicia, Fabrizio; Grelier, Benjamin; de Niel, Jan; Nossent, Jiri; Pereira, Fernando; Savenije, Hubert; Thirel, Guillaume; Willems, Patrick

    2016-04-01

    International collaboration between institutes and universities is a promising way to reach consensus on hydrological model development. Education, experience and expert knowledge of the hydrological community have resulted in the development of a great variety of model concepts, calibration methods and analysis techniques. Although comparison studies are very valuable for international cooperation, they do often not lead to very clear new insights regarding the relevance of the modelled processes. We hypothesise that this is partly caused by model complexity and the used comparison methods, which focus on a good overall performance instead of focusing on specific events. We propose an approach that focuses on the evaluation of specific events. Eight international research groups calibrated their model for the Ourthe catchment in Belgium (1607 km2) and carried out a validation in time for the Ourthe (i.e. on two different periods, one of them on a blind mode for the modellers) and a validation in space for nested and neighbouring catchments of the Meuse in a completely blind mode. For each model, the same protocol was followed and an ensemble of best performing parameter sets was selected. Signatures were first used to assess model performances in the different catchments during validation. Comparison of the models was then followed by evaluation of selected events, which include: low flows, high flows and the transition from low to high flows. While the models show rather similar performances based on general metrics (i.e. Nash-Sutcliffe Efficiency), clear differences can be observed for specific events. While most models are able to simulate high flows well, large differences are observed during low flows and in the ability to capture the first peaks after drier months. The transferability of model parameters to neighbouring and nested catchments is assessed as an additional measure in the model evaluation. This suggested approach helps to select, among competing

  9. Study on Nursing Clinical Teachers' Comprehensive Quality Evaluation Model on the Basis of Fuzzy Mathematics

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    Zhijuan Liu

    2013-04-01

    Full Text Available In this study, we study on the nursing clinical teachers' comprehensive quality evaluation model on the basis of fuzzy mathematics. First, it obtains the nursing clinical teachers' comprehensive quality evaluation index framework by making use of Delphi method. Then, it constructs the comprehensive quality evaluation hierarchy model by applying the analytic hierarchy process, to obtain the weight for each index, based on which to establish fuzzy comprehensive evaluation model, thus acquiring new method for nursing clinical teachers' comprehensive quality evaluation. Examples have proven the feasibility and effectiveness of this method.

  10. Evaluation Model for Experts Social Networks (Based on Case Study

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    Fatemeh Saghafi

    2012-05-01

    Full Text Available Every Social network is considered as a structured Society constitute of individual or organizational group which are associated together within different type of dependency. The most important elements influence the success of such social network is the level of interest for sharing the information. This article addresses the important factors on assessment of Intellectual National Internet Network(ININ. For assessment we propose Enhanced technology acceptance model which we deployed by extending Davis TAM(technology acceptance model.ININ is a web base sites for think thanking of researchers which is acting within a four month at RICT(Research institute of ICT and the number of 214 ICT researchers distribute and delivered their experience. The result shows that in intellectual society, Intelligence has higher values to be disseminated and higher inspiration is needed for its successful sharing in new generation of Information technology.

  11. Basic model study on efficiency evaluation in collaborative design work process

    Institute of Scientific and Technical Information of China (English)

    XIE Qiu; YANG Yu; LI Xiaoli; ZHAO Ningyu

    2007-01-01

    During the efficiency evaluation process of collaborative design work,because of the lack of efficiency evaluation models,a basic analytical model for collaborative design work efficiency evaluation is proposed in this paper.First,the characteristics of the networked collaborative design system work process were studied; then,in accordance with those characteristics,a basic analytical model is created.This model,which is built for centralized collaborative design work,includes an analytical frame,a process view model,a function view model and an information view model.Finally,the application process and steps of this basic analytical model are elaborated when used for efficiency evaluation through an experiment.

  12. Logic models: a useful way to study theories of evaluation practice?

    Science.gov (United States)

    Miller, Robin Lin

    2013-06-01

    This paper comments on the papers in the special volume on logic modeling and evaluation theory. Logic modeling offers a potentially useful approach to learning about the assumptions, activities, and consequences described in an evaluation theory and may facilitate comparative analysis of evaluation theories. However, logic models are imperfect vehicles for depicting the contingent and dynamic nature of evaluation theories. Alternative approaches to studying theories are necessary to capture the essence of theories as they may work in actual practice. Copyright © 2012 Elsevier Ltd. All rights reserved.

  13. Comparison and Evaluation of Three Animal Models for Studying the Pathogenicity of Staphylococcus epidermidis

    Institute of Scientific and Technical Information of China (English)

    李华林; 王勇翔; 陈喆; 齐玲; 瞿涤; 闻玉梅

    2003-01-01

    In order to compare and evaluate three animal models for studying the pathogenicity of Staphylococcus epidermidis strains, three experimental animal models, namely, murine intra-venous LD50, mouse foreign body infection and rat central venous catheter (CVC) infection models were used to assess the relative virulence of two S. epidermidis strains, ATCC 12228 and 97-337. The results from three animal models were comparable, indicating S. epidermidis 97-337 was more virulent than strain ATCC 12228. The rat CVC infection model best mimicked the conditions of clinical patients with intmvenonscatheters, and more information could be obtained from this model. We conclude that different in vivo models serve for dif-ferent purposes, and the rat CVC infection model is most suitable for studying specific characteristics of catheter related infections caused by S. epidermidis stratus.

  14. An Empirical Study of Kirkpatrick's Evaluation Model in the Hospitality Industry

    Science.gov (United States)

    Chang, Ya-Hui Elegance

    2010-01-01

    This study examined Kirkpatrick's training evaluation model (Kirkpatrick & Kirkpatrick, 2006) by assessing a sales training program conducted at an organization in the hospitality industry. The study assessed the employees' training outcomes of knowledge and skills, job performance, and the impact of the training upon the organization. By…

  15. An Empirical Study of Kirkpatrick's Evaluation Model in the Hospitality Industry

    Science.gov (United States)

    Chang, Ya-Hui Elegance

    2010-01-01

    This study examined Kirkpatrick's training evaluation model (Kirkpatrick & Kirkpatrick, 2006) by assessing a sales training program conducted at an organization in the hospitality industry. The study assessed the employees' training outcomes of knowledge and skills, job performance, and the impact of the training upon the organization. By…

  16. A study on the sound quality evaluation model of mechanical air-cleaners

    DEFF Research Database (Denmark)

    Ih, Jeong-Guon; Jang, Su-Won; Jeong, Cheol-Ho;

    2009-01-01

    of an immediate cleaning of pollutants. In this context, it is important to evaluate and design the air-cleaner noise to satisfy such contradictory expectations from the customers. In this study, a model for evaluating the sound quality of air-cleaners of mechanical type was developed based on objective...... perceptive descriptor. Annoyance and performance indices of air-cleaners were modeled from the subjective responses of the juries and the measured sound quality metrics: loudness, sharpness, roughness, and fluctuation strength. The multiple regression method was employed to generate sound quality evaluation...... models. Using the developed indices, sound quality of the measured data was evaluated and compared with the subjective data. The difference between predicted and tested scores was less than 0.5 points. © 2009 by ASME....

  17. Evaluation of a target region capture sequencing platform using monogenic diabetes as a study-model

    DEFF Research Database (Denmark)

    Gao, R.; Liu, Y. X.; Gjesing, A. P.;

    2014-01-01

    diabetes as a study-model. Results: The performance of the assay was evaluated in 70 patients carrying known disease causing mutations previously identified in HNF4A, GCK, HNF1A, HNF1B, INS, or KCNJ11. Target regions with a less than 20-fold sequencing depth were either introns or UTRs. When only...

  18. A Study on Evaluation Model of IT Industry's Innovation Capability Based Variable Weight Theory

    Institute of Scientific and Technical Information of China (English)

    LI Zi-biao; WANG lei; HU Bao-min

    2006-01-01

    In this paper, IT Industry's innovation capability is considered to be the innovation output capability after complex operation of industry input in industry system. In this complex process, R&D personnel input and R&D expense input are un-substitutable, and for evaluation of innovation capability, innovation input and innovation output also are un-substitutable. Based on this theory, an evaluation model of sustaining strength index is put forward. Considering both input scale and output contribution of IT industry's innovation system, this model reflects the un-substitutability of every evaluation aspects. The measurement result not only shows the industry innovation capability, but also reflects the support degree to economy. At last the data of IT industry in China are provided between 1994 and 2004 for empirical study.

  19. A Study of Developing a System Dynamics Model for the Learning Effectiveness Evaluation

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    Tian-Syung Lan

    2013-01-01

    Full Text Available This study used the research method of system dynamics and applied the Vensim software to develop a learning effectiveness evaluation model. This study developed four cause-and-effect chains affecting learning effectiveness, including teachers’ teaching enthusiasm, family involvement, school’s implementation of scientific activities, and creative teaching method, as well as the system dynamics model based on the four cause-and-effect chains. Based on the developed system dynamic model, this study performed simulation to investigate the relationship among family involvement, learning effectiveness, teaching achievement, creative teaching method, and students’ learning interest. The results of this study verified that there are positive correlations between family involvement and students’ learning effectiveness, as well as students’ learning effectiveness and teachers’ teaching achievements. The results also indicated that the use of creative teaching method is able to increase students’ learning interest and learning achievement.

  20. Petrophysical studies of north American carbonate rock samples and evaluation of pore-volume compressibility models

    Science.gov (United States)

    da Silva, Gilberto Peixoto; Franco, Daniel R.; Stael, Giovanni C.; da Costa de Oliveira Lima, Maira; Sant'Anna Martins, Ricardo; de Moraes França, Olívia; Azeredo, Rodrigo B. V.

    2015-12-01

    In this work, we evaluate two pore volume compressibility models that are currently discussed in the literature (Horne, 1990; Jalalh, 2006b). Five groups of carbonate rock samples from the three following sedimentary basins in North America that are known for their association with hydrocarbon deposits were selected for this study: (i) the Guelph Formation of the Michigan Basin (Middle Silurian); (ii) the Edwards Formation of the Central Texas Platform (Middle Cretaceous); and (iii) the Burlington-Keokuk Formation of the Mississippian System (Lower Mississippian). In addition to the evaluation of the compressibility model, a petrophysical evaluation of these rock samples was conducted. Additional characterizations, such as grain density, the effective porosity, absolute grain permeability, thin section petrography, MICP and NMR, were performed to complement constant pore-pressure compressibility tests. Although both models presented an overall good representation of the compressibility behavior of the studied carbonate rocks, even when considering their broad porosity range (~ 2-38%), the model proposed by Jalalh (2006b) performed better with a confidence level of 95% and a prediction interval of 68%.

  1. Evaluation Model for Scientific Quality Based on Rough Sets and Its Empirical Study

    Institute of Scientific and Technical Information of China (English)

    LIU Dun; HU Pei; JIANG Chao-zhe; LIU Li

    2007-01-01

    By analyzing the questionnaires recollected from 74 different government departments in Chengdu, China, an evaluation model for scientific quality of civil servants was developed with the rough set theory. In the empirical study, a series of important rules were given to help to check and forecast the degree of the scientific quality of civil servants by using the reduction algorithm, and the total accuracy of prediction was 93.2%.

  2. Studying the teaching of kindness: A conceptual model for evaluating kindness education programs in schools.

    Science.gov (United States)

    Kaplan, Deanna M; deBlois, Madeleine; Dominguez, Violeta; Walsh, Michele E

    2016-10-01

    Recent research suggests that school-based kindness education programs may benefit the learning and social-emotional development of youth and may improve school climate and school safety outcomes. However, how and to what extent kindness education programming influences positive outcomes in schools is poorly understood, and such programs are difficult to evaluate in the absence of a conceptual model for studying their effectiveness. In partnership with Kind Campus, a widely adopted school-based kindness education program that uses a bottom-up program framework, a methodology called concept mapping was used to develop a conceptual model for evaluating school-based kindness education programs from the input of 123 middle school students and approximately 150 educators, school professionals, and academic scholars. From the basis of this model, recommendations for processes and outcomes that would be useful to assess in evaluations of kindness education programs are made, and areas where additional instrument development may be necessary are highlighted. The utility of the concept mapping method as an initial step in evaluating other grassroots or non-traditional educational programming is also discussed.

  3. Study on quality evaluation model in multi-station assembly processes

    Institute of Scientific and Technical Information of China (English)

    Wen Zejun; Liu Deshun; Yang Shuyi

    2008-01-01

    Based on features of dimension variation propagation in multi-station assembly processes,a new quality evalu-ation model of assembly processes is established.Firstly,the error source of multi-station assembly system is analyzed,the relationship of dimension variation propagation in multi-station assembly processes is studied and the state equation for variation propagation is constructed too.Then,the feature parameters which influence variation propagation and ac-cumulation in multi-station assembly processes are found to evaluate quality characteristic of the assembly system.Through the derivation of equation on dimension variation propagation,station coefficient matrices which axe combined and conversed to determine the max eigenvalue are educed.The max eigenvalue is multiplied by the weight coefficient to establish the quality evaluation model in multi-station assembly processes.Furthermore,assembly variation indexes are proposed to judge of the assembly technology process.Finally,through the practical example,the application of the model and assembly variation indexes are presented.

  4. Potential and limitations of multidecadal satellite soil moisture observations for selected climate model evaluation studies

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    A. Loew

    2013-09-01

    Full Text Available Soil moisture is an essential climate variable (ECV of major importance for land–atmosphere interactions and global hydrology. An appropriate representation of soil moisture dynamics in global climate models is therefore important. Recently, a first multidecadal, observation-based soil moisture dataset has become available that provides information on soil moisture dynamics from satellite observations (ECVSM, essential climate variable soil moisture. The present study investigates the potential and limitations of this new dataset for several applications in climate model evaluation. We compare soil moisture data from satellite observations, reanalysis and simulations from a state-of-the-art land surface model and analyze relationships between soil moisture and precipitation anomalies in the different dataset. Other potential applications like model parameter optimization or model initialization are not investigated in the present study. In a detailed regional study, we show that ECVSM is capable to capture well the interannual and intraannual soil moisture and precipitation dynamics in the Sahelian region. Current deficits of the new dataset are critically discussed and summarized at the end of the paper to provide guidance for an appropriate usage of the ECVSM dataset for climate studies.

  5. Urban climate model MUKLIMO_3 in prediction mode - evaluation of model performance based on the case study of Vienna

    Science.gov (United States)

    Hollosi, Brigitta; Zuvela-Aloise, Maja

    2017-04-01

    To reduce negative health impacts of extreme heat load in urban areas is the application of early warning systems that use weather forecast models to predict forthcoming heat events of utmost importance. In the state-of-the-art operational heat warning systems the meteorological information relies on the weather forecast from the regional numerical models and monitoring stations that do not include details of urban structure. In this study, the dynamical urban climate model MUKLIMO3 (horizontal resolution of 100 - 200 m) is initialized with the vertical profiles from the archived daily forecast data of the ZAMG from the hydrostatic ALARO numerical weather prediction model run at 0600 UTC to simulate the development of the urban heat island in Vienna on a daily basis. The aim is to evaluate the performance of the urban climate model, so far applied only for climatological studies, in a weather prediction mode using the summer period 2011-2015 as a test period. The focus of the investigation is on assessment of the urban heat load during the day-time. The model output has been evaluated against the monitoring data at the weather stations in the area of the city. The model results for daily maximum temperature show good agreement with the observations, especially at the urban and suburban stations where the mean bias is low. The results are highly dependent on the input data from the meso-scale model that leads to larger deviation from observations if the prediction is not representative for the given day. This study can be used to support urban planning strategies and to improve existing practices to alert decision-makers and the public to impending dangers of excessive heat.

  6. Studies of transformational leadership: evaluating two alternative models of trust and satisfaction.

    Science.gov (United States)

    Yang, Yi-Feng

    2014-06-01

    This study evaluates the influence of leadership style and employee trust in their leaders on job satisfaction. 341 personnel (164 men, 177 women; M age = 33.5 yr., SD = 5.1) from four large insurance companies in Taiwan completed the transformational leadership behavior inventory, the leadership trust scale and a short version of the Minnesota (Job) Satisfaction Questionnaire. A bootstrapping mediation and structural equation modeling revealed that the effect of transformational leadership on job satisfaction was mediated by leadership trust. This study highlights the importance of leadership trust in leadership-satisfaction relationships, and provides managers with practical ways to enhance job satisfaction.

  7. Evaluation of the Cost Estimation Models: Case Study of Task Manager Application

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    Mohammed Mugahed Al Qmase

    2013-10-01

    Full Text Available The need to accurately estimate time and cost for effective planning of software projects is becoming crucial driven by the escalating demands of the software market. Several models proposed in the history of Software Engineering discipline to estimate time, costs associated with planning and managing software projects as Line of Code (LOC, Function Point (FP and Constructive Cost Model (COCOMO. This paper focuses upon the COCOMO Model. It is further consisted of its two sub models called COCOMO I and COCOMO II. The primary objective of this research is to use an appropriate case study to evaluate the accuracy of the sub models COCOMO I and II and ascertain the variation of the realistic resource effort, staff and time. The findings to date show that the Application Composition Model of COCOMO II is more accurate in determining time and cost for the successful conclusion of a software project than the other two COCOMO I and II Models for a similar application for example Task Manager.

  8. The IIR evaluation model

    DEFF Research Database (Denmark)

    Borlund, Pia

    2003-01-01

    An alternative approach to evaluation of interactive information retrieval (IIR) systems, referred to as the IIR evaluation model, is proposed. The model provides a framework for the collection and analysis of IR interaction data. The aim of the model is two-fold: 1) to facilitate the evaluation...... assessments. The IIR evaluation model is presented as an alternative to the system-driven Cranfield model (Cleverdon, Mills & Keen, 1966; Cleverdon & Keen, 1966) which still is the dominant approach to the evaluation of IR and IIR systems. Key elements of the IIR evaluation model are the use of realistic...... of IIR systems as realistically as possible with reference to actual information searching and retrieval processes, though still in a relatively controlled evaluation environment; and 2) to calculate the IIR system performance taking into account the non-binary nature of the assigned relevance...

  9. An Evaluation of iMetric Studies through the Scholarly Influence Model

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    Faramarz Soheili

    2016-12-01

    Full Text Available Among the topics studied in the context of scientometrics, the issue of the scholarly influence is of special interest. This study tries to test the components in the scholarly influence model based on iMetrics studies, and also to find potential relations among these components. The study uses a bibliometric methodology. Since the researchers aim to determine the relationship between variables, this research is of correlation type. The initial data of this study, which comprises 5944 records in the field of iMetrics during 1978-2014, have been retrieved from Web of Science. To calculate the most of measures involved in each kind of influence, the researchers used UCINet and BibExcel software moreover, some indices have been calculated manually using Excel. After calculating all measures included in three types of influence, the researchers used the Smart PLS to test both the model and research hypotheses. The results of data analysis using the software Smart PLS confirmed the scholarly influence model and indicated significant correlation between the variables in the model. To be more precise, findings uncovered that social influence is associated with both ideational and venue influence. Moreover, the venue influence is associated with ideational influence. If researchers test the scholarly influence model in some other areas and led to positive outcomes, it is hoped that the policy-makers use a combination of variables involved in the model as a measure to evaluate the scholarly influence of researchers and to decision-makings related to purposes such as promotion, recruitment, and so on.

  10. Evaluation of new secondary organic aerosol models for a case study in Mexico City

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    K. Dzepina

    2009-02-01

    Full Text Available Recent field studies have found large discrepancies in the measured vs. modeled SOA mass loadings in both urban and regional polluted atmospheres. The reasons for these large differences are unclear. Here we revisit a case study of SOA formation in Mexico City described by Volkamer et al. (2006, during a photochemically active period when the impact of regional biomass burning is minor or negligible, and show that the observed increase in OA/ΔCO is consistent with results from several groups during MILAGRO 2006. Then we use the case study to evaluate three new SOA models: 1 the update of aromatic SOA yields from recent chamber experiments (Ng et al., 2007; 2 the formation of SOA from glyoxal (Volkamer et al., 2007a; and 3 the formation of SOA from primary semivolatile and intermediate volatility species (P-S/IVOC (Robinson et al., 2007. We also evaluate the effect of reduced partitioning of SOA into POA (Song et al., 2007. Traditional SOA precursors (mainly aromatics by themselves still fail to produce enough SOA to match the observations by a factor of 7. The new low-NOx aromatic pathways with very high SOA yields make a very small contribution in this high-NOx urban environment as the RO2.+NO reaction dominates the fate of the RO2. radicals. Glyoxal contributes several μg m−3 to SOA formation, with similar timing as the measurements. P-S/IVOC are estimated from equilibrium with emitted POA, and introduce a large amount of gas-phase oxidizable carbon that was not in models before. With the formulation in Robinson et al. (2007 these species have a high SOA yield, and this mechanism can close the gap in SOA mass between measurements and models in our case study. However the volatility of SOA produced in the model is too high and the O/C ratio is lower than observations. Glyoxal SOA helps to bring the O/C ratio of predicted and observed SOA into better agreement. The

  11. Evaluation of phenoxybenzamine in the CFA model of pain following gene expression studies and connectivity mapping.

    Science.gov (United States)

    Chang, Meiping; Smith, Sarah; Thorpe, Andrew; Barratt, Michael J; Karim, Farzana

    2010-09-16

    We have previously used the rat 4 day Complete Freund's Adjuvant (CFA) model to screen compounds with potential to reduce osteoarthritic pain. The aim of this study was to identify genes altered in this model of osteoarthritic pain and use this information to infer analgesic potential of compounds based on their own gene expression profiles using the Connectivity Map approach. Using microarrays, we identified differentially expressed genes in L4 and L5 dorsal root ganglia (DRG) from rats that had received intraplantar CFA for 4 days compared to matched, untreated control animals. Analysis of these data indicated that the two groups were distinguishable by differences in genes important in immune responses, nerve growth and regeneration. This list of differentially expressed genes defined a "CFA signature". We used the Connectivity Map approach to identify pharmacologic agents in the Broad Institute Build02 database that had gene expression signatures that were inversely related ('negatively connected') with our CFA signature. To test the predictive nature of the Connectivity Map methodology, we tested phenoxybenzamine (an alpha adrenergic receptor antagonist) - one of the most negatively connected compounds identified in this database - for analgesic activity in the CFA model. Our results indicate that at 10 mg/kg, phenoxybenzamine demonstrated analgesia comparable to that of Naproxen in this model. Evaluation of phenoxybenzamine-induced analgesia in the current study lends support to the utility of the Connectivity Map approach for identifying compounds with analgesic properties in the CFA model.

  12. Evaluation Study of Pressure-Strain Correlation Models in Compressible Flow

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    Aicha Hanafi

    2016-01-01

    Full Text Available This paper is devoted to the second-order closure for compressible turbulent flows with special attention paid to modeling the pressure-strain correlation appearing in the Reynolds stress equation. This term appears as the main one responsible for the changes of the turbulence structures that arise from structural compressibility effects. The structure of the gradient Mach number is similar to that of turbulence, therefore this parameter may be appropriate to study the changes in turbulence structures that arise from structural compressibility effects. Thus, the incompressible model (LRR of the pressure-strain correlation and its corrected form by using the turbulent Mach number, fail to correctly evaluate the compressibility effects at high shear flow. An extension of the widely used incompressible model (LRR on compressible homogeneous shear flow is the major aim of the present work. From this extension the standard coefficients Ci became a function of the compressibility parameters (the turbulent Mach number and the gradient Mach number. Application of the model on compressible homogeneous shear flow by considering various initial conditions shows reasonable agreement with the DNS results of Sarkar. The ability of the models to predict the equilibrium states for the flow in cases A1 and A4 from DNS results of Sarkar is examined, the results appear to be very encouraging. Thus, both parameters Mt and Mg should be used to model significant structural compressibility effects at high-speed shear flow.

  13. Evaluating the effectiveness of Neuro web design model in business websites (observational study

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    Boshra Sedghi Shamir

    2016-06-01

    Full Text Available By combining Neuromarketing، social psychology and e-commerce، a new area has been added to the world of consumer neuroscience named Nero web design. The practical Neuro business web design model consists of 67 applicable and implementable techniques in business websites and has been gathered in three sequential phases: attraction، message delivery، and reshaping with the aim of negotiating to the visitor’s brain to increase the conversion rate on a business website. Eight websites have been implemented to evaluate the effectiveness of this model: A simple website without using the model، a complete website (using all 67 techniques in the model، and six other websites that differentiate in reshaping groups. The unique and targeted visitors for each websites obtained through internet advertisements. They became 957 new visitors altogether. In the period of two months of observational studying، Website heat maps that track the mouse movements of visitors، showed that visitors attracted to all parts of the complete website homepage particularly order form module but not so for the simple website. This reflects the success of attraction phase of the model. The results showed that the conversion rate of each of the seven model websites as compared to simple website is greatly high and even more than the international average conversion rate.

  14. Evaluation of a target region capture sequencing platform using monogenic diabetes as a study-model

    DEFF Research Database (Denmark)

    Gao, R.; Liu, Y. X.; Gjesing, A. P.;

    2014-01-01

    Background: Monogenic diabetes is a genetic disease often caused by mutations in genes involved in beta-cell function. Correct sub-categorization of the disease is a prerequisite for appropriate treatment and genetic counseling. Target-region capture sequencing is a combination of genomic region...... diabetes as a study-model. Results: The performance of the assay was evaluated in 70 patients carrying known disease causing mutations previously identified in HNF4A, GCK, HNF1A, HNF1B, INS, or KCNJ11. Target regions with a less than 20-fold sequencing depth were either introns or UTRs. When only...... of monogenic diabetes....

  15. 3D evaluation of palatal rugae for human identification using digital study models

    Directory of Open Access Journals (Sweden)

    Emilia D Taneva

    2015-01-01

    Full Text Available Background: While there is literature suggesting that the palatal rugae could be used for human identification, most of these studies use two-dimensional (2D approach. Aim: The aims of this study were to evaluate palatal ruga patterns using three-dimensional (3D digital models; compare the most clinically relevant digital model conversion techniques for identification of the palatal rugae; develop a protocol for overlay registration; determine changes in palatal ruga individual patterns through time; and investigate the efficiency and accuracy of 3D matching processes between different individuals′ patterns. Material and Methods: Five cross sections in the anteroposterior dimension and four cross sections in the transverse dimension were computed which generated 18 2D variables. In addition, 13 3D variables were defined: The posterior point of incisive papilla (IP, and the most medial and lateral end points of the palatal rugae (R1MR, R1ML, R1LR, R1LL, R2MR, R2ML, R2LR, R2LL, R3MR, R3ML, R3LR, and R3LL. The deviation magnitude for each variable was statistically analyzed in this study. Five different data sets with the same 31 landmarks were evaluated in this study. Results: The results demonstrated that 2D images and linear measurements in the anteroposterior and transverse dimensions were not sufficient for comparing different digital model conversion techniques using the palatal rugae. 3D digital models proved to be a highly effective tool in evaluating different palatal ruga patterns. The 3D landmarks showed no statistically significant mean differences over time or as a result of orthodontic treatment. No statistically significant mean differences were found between different digital model conversion techniques, that is, between OrthoCAD™ and Ortho Insight 3D™, and between Ortho Insight 3D™ and the iTero; scans, when using 12 3D palatal rugae landmarks for comparison. Conclusion: Although 12 palatal 3D landmarks could be used for

  16. 3D evaluation of palatal rugae for human identification using digital study models

    Science.gov (United States)

    Taneva, Emilia D.; Johnson, Andrew; Viana, Grace; Evans, Carla A.

    2015-01-01

    Background: While there is literature suggesting that the palatal rugae could be used for human identification, most of these studies use two-dimensional (2D) approach. Aim: The aims of this study were to evaluate palatal ruga patterns using three-dimensional (3D) digital models; compare the most clinically relevant digital model conversion techniques for identification of the palatal rugae; develop a protocol for overlay registration; determine changes in palatal ruga individual patterns through time; and investigate the efficiency and accuracy of 3D matching processes between different individuals’ patterns. Material and Methods: Five cross sections in the anteroposterior dimension and four cross sections in the transverse dimension were computed which generated 18 2D variables. In addition, 13 3D variables were defined: The posterior point of incisive papilla (IP), and the most medial and lateral end points of the palatal rugae (R1MR, R1ML, R1LR, R1LL, R2MR, R2ML, R2LR, R2LL, R3MR, R3ML, R3LR, and R3LL). The deviation magnitude for each variable was statistically analyzed in this study. Five different data sets with the same 31 landmarks were evaluated in this study. Results: The results demonstrated that 2D images and linear measurements in the anteroposterior and transverse dimensions were not sufficient for comparing different digital model conversion techniques using the palatal rugae. 3D digital models proved to be a highly effective tool in evaluating different palatal ruga patterns. The 3D landmarks showed no statistically significant mean differences over time or as a result of orthodontic treatment. No statistically significant mean differences were found between different digital model conversion techniques, that is, between OrthoCAD™ and Ortho Insight 3D™, and between Ortho Insight 3D™ and the iTero® scans, when using 12 3D palatal rugae landmarks for comparison. Conclusion: Although 12 palatal 3D landmarks could be used for human

  17. 3D evaluation of palatal rugae for human identification using digital study models.

    Science.gov (United States)

    Taneva, Emilia D; Johnson, Andrew; Viana, Grace; Evans, Carla A

    2015-01-01

    While there is literature suggesting that the palatal rugae could be used for human identification, most of these studies use two-dimensional (2D) approach. The aims of this study were to evaluate palatal ruga patterns using three-dimensional (3D) digital models; compare the most clinically relevant digital model conversion techniques for identification of the palatal rugae; develop a protocol for overlay registration; determine changes in palatal ruga individual patterns through time; and investigate the efficiency and accuracy of 3D matching processes between different individuals' patterns. Five cross sections in the anteroposterior dimension and four cross sections in the transverse dimension were computed which generated 18 2D variables. In addition, 13 3D variables were defined: The posterior point of incisive papilla (IP), and the most medial and lateral end points of the palatal rugae (R1MR, R1ML, R1LR, R1LL, R2MR, R2ML, R2LR, R2LL, R3MR, R3ML, R3LR, and R3LL). The deviation magnitude for each variable was statistically analyzed in this study. Five different data sets with the same 31 landmarks were evaluated in this study. The results demonstrated that 2D images and linear measurements in the anteroposterior and transverse dimensions were not sufficient for comparing different digital model conversion techniques using the palatal rugae. 3D digital models proved to be a highly effective tool in evaluating different palatal ruga patterns. The 3D landmarks showed no statistically significant mean differences over time or as a result of orthodontic treatment. No statistically significant mean differences were found between different digital model conversion techniques, that is, between OrthoCAD™ and Ortho Insight 3D™, and between Ortho Insight 3D™ and the iTero(®) scans, when using 12 3D palatal rugae landmarks for comparison. Although 12 palatal 3D landmarks could be used for human identification, certain landmarks were especially important in the

  18. Evaluation of MBEC™-HTP biofilm model for studies of implant associated infections.

    Science.gov (United States)

    Coraça-Hubér, Debora C; Fille, Manfred; Hausdorfer, Johann; Pfaller, Kristian; Nogler, Michael

    2012-07-01

    The bacteria in implant-related infections can evade host defenses by forming biofilms. The more we understand biofilm behavior, the better we can fight against then clinically. In vitro models for biofilms allow tests simulating in vivo conditions. In this study we evaluated the Minimum Biofilm Eradication Concentration-High Throughput Plates (MBEC™-HTP) as biofilm in vitro model for studies of implant associated infections. Staphylococcus aureus and Staphylococcus epidermidis biofilms were grown on MBEC™-HTP. To ensure the biofilm formation, antibiotic susceptibility tests and scanning electron microscopy (SEM) was carried out. Susceptibility tests were carried out using gentamicin, vancomycin, rifampicin, fosfomycin, clindamycin, and linezolid. Colony forming units counting were carried out. Minimal inhibitory concentration (MIC) and biofilm inhibitory concentration (BIC) were estimated. The CFU counting showed potency of rifampicin and daptomycin against S. epidermidis biofilms and rifampicin against S. aureus biofilms. SEM images showed proteic material in contact with cells. The differences between BIC and MIC demonstrated the biofilm formation as well as the SEM images. Rifampicin and daptomycin are good choices against biofilm related infections. Moreover, after suggested modifications, the model used in this study is eligible to further studies of implant associated infections. Copyright © 2012 Orthopaedic Research Society.

  19. Evaluating Hub and Spoke models of practice learning in Scotland, UK: a multiple case study approach.

    Science.gov (United States)

    Roxburgh, Michelle; Conlon, Margaret; Banks, Debbie

    2012-10-01

    Most of UK students' practice learning experience is based on a rotational placement model which often leads to students lacking confidence and feeling anxious about the complexities of the care environment. To evaluate the impact of Hub and Spoke model(s) of clinical practice placement across geographically diverse locations, with a particular focus on enhancing the student practice learning experience. Multiple case study design. Comprised undergraduate student nurses from Adult, Learning Disability and Mental Health programmes from 3 Scottish Schools of Nursing. A mixed methods approach which included quantitative and qualitative date tools. All three Hub and Spoke models shared two broad findings: 1) In the three Hub and Spoke models detailed in this paper, there is a continuum of student led learning which supports the process with opportunities for individual students to be positively innovative and creative in their learning approaches. Depth of learning was achieved in two ways; a) the method in which Hub placements are organised, managed and structured and, b) the depth of empathy and sensitivity to the individual at the centre of the care. 2) Placement capacity is increased: The classification of placements is reviewed to produce broader categories, Engagement of mentors/enhanced student/mentor relationship. Practice Learning must be seen as an academic endeavour that promotes deep, meaningful, person-centred learning rather than superficial, compartmentalised placement-centred learning. Copyright © 2012 Elsevier Ltd. All rights reserved.

  20. Comparative approaches from empirical to mechanistic simulation modelling in Land Evaluation studies

    Science.gov (United States)

    Manna, P.; Basile, A.; Bonfante, A.; Terribile, F.

    2009-04-01

    The Land Evaluation (LE) comprise the evaluation procedures to asses the attitudes of the land to a generic or specific use (e.g. biomass production). From local to regional and national scale the approach to the land use planning should requires a deep knowledge of the processes that drive the functioning of the soil-plant-atmosphere system. According to the classical approaches the assessment of attitudes is the result of a qualitative comparison between the land/soil physical properties and the land use requirements. These approaches have a quick and inexpensive applicability; however, they are based on empirical and qualitative models with a basic knowledge structure specifically built for a specific landscape and for the specific object of the evaluation (e.g. crop). The outcome from this situation is the huge difficulties in the spatial extrapolation of the LE results and the rigidity of the system. Modern techniques instead, rely on the application of mechanistic and quantitative simulation modelling that allow a dynamic characterisation of the interrelated physical and chemical processes taking place in the soil landscape. Moreover, the insertion of physical based rules in the LE procedure may make it less difficult in terms of both extending spatially the results and changing the object (e.g. crop species, nitrate dynamics, etc.) of the evaluation. On the other side these modern approaches require high quality and quantity of input data that cause a significant increase in costs. In this scenario nowadays the LE expert is asked to choose the best LE methodology considering costs, complexity of the procedure and benefits in handling a specific land evaluation. In this work we performed a forage maize land suitability study by comparing 9 different methods having increasing complexity and costs. The study area, of about 2000 ha, is located in North Italy in the Lodi plain (Po valley). The range of the 9 employed methods ranged from standard LE approaches to

  1. Improving uncertainty evaluation of process models by using pedigree analysis. A case study on CO2 capture with monoethanolamine

    NARCIS (Netherlands)

    van der Spek, Mijndert; Ramirez, Andrea|info:eu-repo/dai/nl/284852414; Faaij, André

    2016-01-01

    This article aims to improve uncertainty evaluation of process models by combining a quantitative uncertainty evaluation method (data validation) with a qualitative uncertainty evaluation method (pedigree analysis). The approach is tested on a case study of monoethanolamine based postcombustion CO2

  2. Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands.

    Science.gov (United States)

    Peng, Xin; Wang, Qi; Mishra, Yogesh; Xu, Jinbin; Reichert, David E; Malik, Maninder; Taylor, Michelle; Luedtke, Robert R; Mach, Robert H

    2015-02-01

    A series of 2-methoxyphenyl piperazine analogues containing a triazole ring were synthesized and their in vitro binding affinities at human dopamine D2 and D3 receptors were evaluated. Compounds 5b, 5c, 5d, and 4g, demonstrate high affinity for dopamine D3 receptors and moderate selectivity for the dopamine D3 versus D2 receptor subtypes. To further examine their potential as therapeutic agents, their intrinsic efficacy at both D2 and D3 receptors was determined using a forskolin-dependent adenylyl cyclase inhibition assay. Affinity at dopamine D4 and serotonin 5-HT1A receptors was also determined. In addition, information from previous molecular modeling studies of the binding of a panel of 163 structurally-related benzamide analogues at dopamine D2 and D3 receptors was applied to this series of compounds. The results of the modeling studies were consistent with our previous experimental data. More importantly, the modeling study results explained why the replacement of the amide linkage with the hetero-aromatic ring leads to a reduction in the affinity of these compounds at D3 receptors.

  3. Model performance evaluation (validation and calibration) in model-based studies of therapeutic interventions for cardiovascular diseases : a review and suggested reporting framework.

    Science.gov (United States)

    Haji Ali Afzali, Hossein; Gray, Jodi; Karnon, Jonathan

    2013-04-01

    Decision analytic models play an increasingly important role in the economic evaluation of health technologies. Given uncertainties around the assumptions used to develop such models, several guidelines have been published to identify and assess 'best practice' in the model development process, including general modelling approach (e.g., time horizon), model structure, input data and model performance evaluation. This paper focuses on model performance evaluation. In the absence of a sufficient level of detail around model performance evaluation, concerns regarding the accuracy of model outputs, and hence the credibility of such models, are frequently raised. Following presentation of its components, a review of the application and reporting of model performance evaluation is presented. Taking cardiovascular disease as an illustrative example, the review investigates the use of face validity, internal validity, external validity, and cross model validity. As a part of the performance evaluation process, model calibration is also discussed and its use in applied studies investigated. The review found that the application and reporting of model performance evaluation across 81 studies of treatment for cardiovascular disease was variable. Cross-model validation was reported in 55 % of the reviewed studies, though the level of detail provided varied considerably. We found that very few studies documented other types of validity, and only 6 % of the reviewed articles reported a calibration process. Considering the above findings, we propose a comprehensive model performance evaluation framework (checklist), informed by a review of best-practice guidelines. This framework provides a basis for more accurate and consistent documentation of model performance evaluation. This will improve the peer review process and the comparability of modelling studies. Recognising the fundamental role of decision analytic models in informing public funding decisions, the proposed

  4. Evaluation of the Extended CBD Model: A Case Study using IMS Application

    Directory of Open Access Journals (Sweden)

    M. Rizwan Jameel Qureshi

    2013-06-01

    Full Text Available A large number of projects failed because of concentrating on developing new software. The Main drawbacks of new software development are more costly, and need maintenance. Reuse is solution of these problems that caused the widespread usage of object oriented (OO development. Object oriented development is the backbone of component-based development (CBD. CBD facilitates reuse of the existing components (by customizing with the new ones. Main advantages of reusable components are more reliable, saved time and reduced cost. CBD approach is different from traditional/new software development. Several models have been proposed for traditional software development such as Waterfall, Rapid Application Development (RAD, Evolutionary, Rational Unified Process (RUP and agile. Whereas the popular CBD models, for customized development, are V, Y, Umbrella and W. Almost all software development companies, both the new software and customized software have to be developed. Therefore majority of the software development companies face problem to select and implement an appropriate process model for the both kinds of developments. To address this problem, the existing RUP and CBD models do work to some extent but the authors intend to propose an extended CBD model that it equally offers its benefits for new and customized developments. The experimental data is taken from a case study to develop IP Multimedia Sub System (IMS-based examination application using iPhone to evaluate the proposed model. The results provide evidence that the extended CBD model can be equally beneficial for the development of both new and customization components for IMS-based applications.

  5. Pragmatic geometric model evaluation

    Science.gov (United States)

    Pamer, Robert

    2015-04-01

    Quantification of subsurface model reliability is mathematically and technically demanding as there are many different sources of uncertainty and some of the factors can be assessed merely in a subjective way. For many practical applications in industry or risk assessment (e. g. geothermal drilling) a quantitative estimation of possible geometric variations in depth unit is preferred over relative numbers because of cost calculations for different scenarios. The talk gives an overview of several factors that affect the geometry of structural subsurface models that are based upon typical geological survey organization (GSO) data like geological maps, borehole data and conceptually driven construction of subsurface elements (e. g. fault network). Within the context of the trans-European project "GeoMol" uncertainty analysis has to be very pragmatic also because of different data rights, data policies and modelling software between the project partners. In a case study a two-step evaluation methodology for geometric subsurface model uncertainty is being developed. In a first step several models of the same volume of interest have been calculated by omitting successively more and more input data types (seismic constraints, fault network, outcrop data). The positions of the various horizon surfaces are then compared. The procedure is equivalent to comparing data of various levels of detail and therefore structural complexity. This gives a measure of the structural significance of each data set in space and as a consequence areas of geometric complexity are identified. These areas are usually very data sensitive hence geometric variability in between individual data points in these areas is higher than in areas of low structural complexity. Instead of calculating a multitude of different models by varying some input data or parameters as it is done by Monte-Carlo-simulations, the aim of the second step of the evaluation procedure (which is part of the ongoing work) is to

  6. Study on the Manufacturability Evaluation Based on Double-layer Model of Manufacturing Resources

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Virtual organization is a new production patter and a principal part in advanced manufacturing systems such as agile manufacturing. Manufacturability evaluation is the necessary condition to form the virtual organization. A new manufacturability evaluation approach is described in this paper, which is carried out based on every process feature under the double-layer model of manufacturing resources proposed by authors. The manufacturing resources that build up the virtual organization are selected according to the results of manufacturability evaluation.

  7. Evaluation of an experimental rat model for comparative studies of bleaching agents

    Directory of Open Access Journals (Sweden)

    Luciano Tavares Angelo Cintra

    2016-02-01

    Full Text Available ABSTRACT Dental materials, in general, are tested in different animal models prior to their clinical use in humans, except for bleaching agents. Objectives To evaluate an experimental rat model for comparative studies of bleaching agents by investigating the influence of different concentrations and application times of H2O2 gel in the pulp tissue during in-office bleaching of rats’ vital teeth. Material and methods The right and left maxillary molars of 50 Wistar rats were bleached with 20% and 35% H2O2 gels, respectively, for 5, 10, 15, 30, or 45 min (n=10 rats/group. Ten animals (control were untreated. The rats were killed after 2 or 30 days, and the maxillae were examined by light microscopy. Inflammation was evaluated by histomorphometric analysis with inflammatory cell counting in the coronal and radicular thirds of the pulp. The counting of fibroblasts was also performed. Scores were attributed to the odontoblastic layer and to vascular changes. The tertiary dentin area and the pulp chamber central area were histomorphometrically measured. Data were compared by the analysis of variance and the Kruskal-Wallis test (p<0.05. Results After 2 days, the amount of inflammatory cells increased in the occlusal third of the coronal pulp until the time of 15 min for both concentrations of bleaching gels. In 30 and 45 min groups of each concentration, the number of inflammatory cells decreased along with the appearance of necrotic areas. After 30 days, a reduction in the pulp chamber central area and an enlargement of tertiary dentin area were observed without the detection of inflammation areas. Conclusion The rat model of extra coronal bleaching showed to be adequate for bleaching protocols studies, as it was possible to observe alterations in the pulp tissues and in the tooth structure caused by different concentrations and periods of application of bleaching agents.

  8. Evaluation of an experimental rat model for comparative studies of bleaching agents

    Science.gov (United States)

    CINTRA, Luciano Tavares Angelo; BENETTI, Francine; FERREIRA, Luciana Louzada; RAHAL, Vanessa; ERVOLINO, Edilson; JACINTO, Rogério de Castilho; GOMES, João Eduardo; BRISO, André Luiz Fraga

    2016-01-01

    ABSTRACT Dental materials in general are tested in different animal models prior to the clinical use in humans, except for bleaching agents. Objectives To evaluate an experimental rat model for comparative studies of bleaching agents, by investigating the influence of different concentrations and application times of H2O2 gel in the pulp tissue during in-office bleaching of rats’ vital teeth. Material and Methods The right and left maxillary molars of 50 Wistar rats were bleached with 20% and 35% H2O2 gels, respectively, for 5, 10, 15, 30, or 45 min (n=10 rats/group). Ten animals were untreated (control). The rats were killed after 2 or 30 days, and the maxillae were examined by light microscopy. Inflammation was evaluated through histomorphometric analysis with inflammatory cell count in the coronal and radicular thirds of the pulp. Fibroblasts were also counted. Scores were attributed to odontoblastic layer and vascular changes. Tertiary dentin area and pulp chamber central area were measured histomorphometrically. Data were compared by analysis of variance and Kruskal-Wallis test (p<0.05). Results After 2 days, the amount of inflammatory cells increased in the coronal pulp occlusal third up to the 15-min application groups of each bleaching gel. In the groups exposed to each concentration for 30 and 45 min, the number of inflammatory cells decreased along with the appearance of necrotic areas. After 30 days, reduction on the pulp chamber central area and enlargement of the tertiary dentin area were observed, without the detection of inflammation areas. Conclusion The rat model of extracoronal bleaching showed to be adequate for studies of bleaching protocols, as it was possible to observe alterations in the pulp tissues and tooth structure caused by different concentrations and application periods of bleaching agents. PMID:27119766

  9. Mining, modeling, and evaluation of subnetworks from large biomolecular networks and its comparison study.

    Science.gov (United States)

    Hu, Xiaohua; Ng, Michael; Wu, Fang-Xiang; Sokhansanj, Bahrad A

    2009-03-01

    In this paper, we present a novel method to mine, model, and evaluate a regulatory system executing cellular functions that can be represented as a biomolecular network. Our method consists of two steps. First, a novel scale-free network clustering approach is applied to such a biomolecular network to obtain various subnetworks. Second, computational models are generated for the subnetworks and simulated to predict their behavior in the cellular context. We discuss and evaluate some of the advanced computational modeling approaches, in particular, state-space modeling, probabilistic Boolean network modeling, and fuzzy logic modeling. The modeling and simulation results represent hypotheses that are tested against high-throughput biological datasets (microarrays and/or genetic screens) under normal and perturbation conditions. Experimental results on time-series gene expression data for the human cell cycle indicate that our approach is promising for subnetwork mining and simulation from large biomolecular networks.

  10. [Evaluation of Gastric Mucosal Injury Model Animals of Rebamipide Formulation--Study of Therapeutic Equivalence].

    Science.gov (United States)

    Abe, Noriaki; Funato, Hiroki; Hirata, Ayumu; Nakai, Megumi; Iizuka, Michiro; Shiraishi, Hisashi; Jobu, Kohei; Yagi, Yusuke; Kadota, Aki; Ogi, Kyoko; Yokota, Junko; Miyamura, Mitsuhiko

    2016-01-01

    The introduction of generic drugs is promoted from the perspective of medical economics. In this context, we need to understand not only the bioequivalence of generic drugs specified in "the Guidelines for Bioequivalence Studies of Generic Products", but also formulation properties to consider their effect on pharmacological therapy. We evaluated the pharmaceutical characteristics of rebamipide formulations, a brand-name drug and two generic drugs, and their clinical functionality by using rat models of gastric mucosal injury induced by non-steroidal anti-inflammatory drugs (NSAIDs). Pharmaceutical evaluation showed significant differences in hardness. The inter-lot variation was small in all rebamipide formulations. In the clinical functionality study, biochemistry test values 7 d after the administration of rebamipide showed no differences among formulations. Higher levels of mucosal fluid secretion and antioxidative enzymes were observed in the groups administered rebamipide than in the control group. The levels of lipid peroxide were lower in the groups administered rebamipide than the control group. Multivariate analysis showed slight divergence between the brand-name and generic drugs. In future, it will be necessary to select generic drugs after careful consideration of bioequivalence, clinical functionality, and therapeutic equivalence by reviewing scientific evidence such as indication and formulation design, not to mention stable provision.

  11. CREATING AND EVALUATING SUSTAINABLE BUSINESS MODELS – A CROSS-INDUSTRY CASE STUDY

    DEFF Research Database (Denmark)

    Aagaard, Annabeth

    of understanding, creating and evaluating businesses and their business models. The objective of this article is to explore how sustainable business models can be created and evaluated across different companies and industrial contexts. Although many authors have stressed the business potentials of sustainable......Sustainability has become a new premise for doing business - moving it from political discourses into company boardrooms (Dryzek, 2005; Bisgaard, 2009; Aagaard, 2016). However, applying business model innovation as a way to create sustainable value requires several alterations of our ways...

  12. Study on ecological impact evaluation for land consolidation based on cloud model: a case study of Miaotan town

    Science.gov (United States)

    Liu, Yao-lin; Fan, Min; Yang, Xiao-yu; Liu, Hui

    2008-10-01

    Combining the basic theory of cloud model and the process of ecological impact evaluation for land consolidation, the author constructs the rule of ecological impact evaluation and the cloud models of the antecedent and the consequent, by translating the uncertain factor conditions into quantitative values with the uncertain illation based on cloud model, computes the evaluation factor scores and comprehensive scores of MiaoTan, and then, comparing the results with composite index computation method and fuzzy comprehensive assessment, a feasible method used in Ecological Impact Evaluation for Land Consolidation is proposed.

  13. Introducing Program Evaluation Models

    Directory of Open Access Journals (Sweden)

    Raluca GÂRBOAN

    2008-02-01

    Full Text Available Programs and project evaluation models can be extremely useful in project planning and management. The aim is to set the right questions as soon as possible in order to see in time and deal with the unwanted program effects, as well as to encourage the positive elements of the project impact. In short, different evaluation models are used in order to minimize losses and maximize the benefits of the interventions upon small or large social groups. This article introduces some of the most recently used evaluation models.

  14. Aerosol as a player in the Arctic Amplification - an aerosol-climate model evaluation study

    Science.gov (United States)

    Schacht, Jacob; Heinold, Bernd; Tegen, Ina

    2017-04-01

    Climate warming is much more pronounced in the Arctic than in any other region on Earth - a phenomenon referred to as the "Arctic Amplification". This is closely related to a variety of specific feedback mechanisms, which relative importance, however, is not yet sufficiently understood. The local changes in the Arctic climate are far-reaching and affect for example the general atmospheric circulation and global energy transport. Aerosol particles from long-range transport and local sources play an important role in the Arctic system by modulating the energy balance (directly by interaction with solar and thermal infrared radiation and indirectly by changing cloud properties and atmospheric dynamics). The main source regions of anthropogenic aerosol are Europe and East Asia, but also local shipping and oil/gas extraction may contribute significantly. In addition, important sources are widespread, mainly natural boreal forest fires. Most of the European aerosol is transported through the lower atmospheric layers in wintertime. The Asian aerosol is transported through higher altitudes. Because of the usually pristine conditions in the Arctic even small absolute changes in aerosol concentration can have large impacts on the Arctic climate. Using global and Arctic-focused model simulations, we aim at investigating the sources and transport pathways of natural and anthropogenic aerosol to the Arctic region, as well as their impact on radiation and clouds. Here, we present first results from an aerosol-climate model evaluation study. Simulations were performed with the global aerosol-climate model ECHAM6-HAM2, using three different state-of-the-art emission inventories (ACCMIP, ACCMIP + GFAS emissions for wildfires and ECLIPSE). The runs were performed in nudged mode at T63 horizontal resolution (approximately 1.8°) with 47 vertical levels for the 10-year period 2006-2015. Black carbon (BC) and sulphate (SO4) are of particular interest. BC is highly absorbing in the

  15. Study on development of education model and its evaluation system for radiation safety

    CERN Document Server

    Seo, K W; Nam, Y M

    2002-01-01

    As one of the detailed action strategy of multi object preparedness for strengthening of radiation safety management by MOST, this project was performed, in order to promote the safety culture for user and radiation worker through effective education program. For the prevention of radiological accident and effective implementation of radiation safety education and training, this project has been carried out the development of education model and its evaluation system on radiation safety. In the development of new education model, education course was classified; new and old radiation worker, temporary worker, lecturer and manager. The education model includes the contents of expanding the education opportunity and workplace training. In the development of evaluation system, the recognition criteria for commission-education institute and inside-education institute which should establish by law were suggested for evaluation program. The recognition criteria contains classification, student, method, facilities, ...

  16. Evaluating indoor exposure modeling alternatives for LCA: A case study in the vehicle repair industry

    Energy Technology Data Exchange (ETDEWEB)

    Demou, Evangelia; Hellweg, Stefanie; Wilson, Michael P.; Hammond, S. Katharine; McKone, Thomas E.

    2009-05-01

    We evaluated three exposure models with data obtained from measurements among workers who use"aerosol" solvent products in the vehicle repair industry and with field experiments using these products to simulate the same exposure conditions. The three exposure models were the: 1) homogeneously-mixed-one-box model, 2) multi-zone model, and 3) eddy-diffusion model. Temporally differentiated real-time breathing zone volatile organic compound (VOC) concentration measurements, integrated far-field area samples, and simulated experiments were used in estimating parameters, such as emission rates, diffusivity, and near-field dimensions. We assessed differences in model input requirements and their efficacy for predictive modeling. The One-box model was not able to resemble the temporal profile of exposure concentrations, but it performed well concerning time-weighted exposure over extended time periods. However, this model required an adjustment for spatial concentration gradients. Multi-zone models and diffusion-models may solve this problem. However, we found that the reliable use of both these models requires extensive field data to appropriately define pivotal parameters such as diffusivity or near-field dimensions. We conclude that it is difficult to apply these models for predicting VOC exposures in the workplace. However, for comparative exposure scenarios in life-cycle assessment they may be useful.

  17. Blended Learning Analytics Model for Evaluation (BLAME). Et case-studie af universitetsunderviseres brug af Blackboard

    DEFF Research Database (Denmark)

    Musaeus, Peter; Bennedsen, Andreas Brændstrup; Hansen, Janne Saltoft

    2015-01-01

    I denne artikel vil vi præsentere en strategi til inddragelse af læringsanalytik (learning analytics) ved evaluering af universitetsunderviseres brug af et nyt LMS på Aarhus Universitet: Blackboard. Vi diskuterer en model (BLAME: Blended Learning Analytics Model of Evaluation) for, hvordan...... kategorisering af kurser og data om læringsanalytik indsamlet på Blackboard kan integreres. Endvidere belyser vi, hvilke implikationer en sådan læringsanalytik kan have for blended learning ved at analysere to forskellige uddannelses-cases/illustrationer. Dernæst diskuterer vi pædagogisk udvikling i forbindelse...

  18. Blended Learning Analytics Model for Evaluation (BLAME). Et case-studie af universitetsunderviseres brug af Blackboard

    DEFF Research Database (Denmark)

    Musaeus, Peter; Bennedsen, Andreas Brændstrup; Hansen, Janne Saltoft

    2015-01-01

    I denne artikel vil vi præsentere en strategi til inddragelse af læringsanalytik (learning analytics) ved evaluering af universitetsunderviseres brug af et nyt LMS på Aarhus Universitet: Blackboard. Vi diskuterer en model (BLAME: Blended Learning Analytics Model of Evaluation) for, hvordan...... kategorisering af kurser og data om læringsanalytik indsamlet på Blackboard kan integreres. Endvidere belyser vi, hvilke implikationer en sådan læringsanalytik kan have for blended learning ved at analysere to forskellige uddannelses-cases/illustrationer. Dernæst diskuterer vi pædagogisk udvikling i forbindelse...

  19. Evaluation of the ERP dispersion model using Darlington tracer-study data. Report No. 90-200-K

    Energy Technology Data Exchange (ETDEWEB)

    Wright, S.C.

    1990-01-01

    In this study, site-boundary atmospheric dilution factors calculated by the atmospheric dispersion model used in the ERP (Emergency Response Planning) computer code were compared to data collected during the Darlington tracer study. The purpose of this comparison was to obtain estimates of model uncertainty under a variety of conditions. This report provides background on ERP, the ERP dispersion model and the Darlington tracer study. Model evaluation techniques are discussed briefly, and the results of the comparison of model calculations with the field data are presented and reviewed.

  20. Comprehensive benefit of flood resources utilization through dynamic successive fuzzy evaluation model: A case study

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Taking the flood resources utilization in Baicheng, Jilin during 2002–2007 as the research background, and based on the entropy weight and multi-level & multi-objective fuzzy optimization theory, this research established a multi-level & semi-constructive index system and dynamic successive evaluation model for comprehensive benefit evaluation of regional flood resources utilization. With the year 2002 as the base year, the analyzing results showed that there existed a close positive correlation between flood utilization volume and its benefits, comprehensive evaluation value and its comparison increment. Within the six successive evaluation years, the comprehensive benefit of 2003 was the best, in which the benefit evaluation increment reached 82.8% whereas the year of 2004 was the worst, in which the increment was only 18.2%. Thus the sustainability and correctness of the evaluation were verified by six years successive evaluation and increment comparison. The analyzing results showed that the economic benefits, ecological benefits and social benefits of flood utilization were remarkable, and that the comprehensive benefit could be improved by increasing flood utilization capacity, which would promote the regional sustainable development as well. The established dynamic successive evaluation provides a stable theoretical basis and technical support for further flood utilization.

  1. Innovation evaluation model for macro-construction sector companies: A study in Spain.

    Science.gov (United States)

    Zubizarreta, Mikel; Cuadrado, Jesús; Iradi, Jon; García, Harkaitz; Orbe, Aimar

    2017-04-01

    The innovativeness of the traditional construction sector, composed of construction companies or contractors, is not one of its strong points. Likewise, its poor productivity in comparison with other sectors, such as manufacturing, has historically been criticized. Similar features are found in the Spanish traditional construction sector, which it has been described as not very innovative. However, certain characteristics of the sector may explain this behavior; the companies invest in R+D less than in other sectors and release fewer patents, so traditional innovation evaluation indicators do not reflect the true extent of its innovative activity. While previous research has focused on general innovation evaluation models, limited research has been done regarding innovation evaluation in the macro-construction sector, which includes, apart from the traditional construction companies or contractors, all companies related to the infrastructure life-cycle. Therefore, in this research an innovation evaluation model has been developed for macro-construction sector companies and is applied in the Spanish case. The model may be applied to the macro-construction sector companies in other countries, requiring the adaption of the model to the specific characteristics of the sector in that country, in consultation with a panel of experts at a national level.

  2. Empirical Evaluation of the Proposed eXSCRUM Model-Results of a Case Study

    Directory of Open Access Journals (Sweden)

    M Rizwan Jameel Qureshi

    2011-05-01

    Full Text Available Agile models promote fast development. XP and Scrum are the most widely used agile models. This paper investigates the phases of XP and Scrum models in order to identify their potentials and drawbacks. XP model has certain drawbacks, such as not suitable for maintenance projects and poor performance for medium and large-scale development projects. Scrum model has certain limitations, such as lacked in engineering practices. Since, both XP and Scrum models contain good features and strengths but still there are improvement possibilities in these models. Majority of the software development companies are reluctant to switch from traditional methodologies to agile methodologies for development of industrial projects. A fine integration, of software management of the Scrum model and engineering practices of XP model, is very much required to accumulate the strengths and remove the limitations of both models. This is achieved by proposing an eXScrum model. The proposed model is validated by conducting a controlled case study. The results of case study show that the proposed integrated eXScrum model enriches the potentials of both XP and Scrum models and eliminates their drawbacks.

  3. MRI evaluation of infectious and non-infectious synovitis: preliminary studies in a rabbit model

    Energy Technology Data Exchange (ETDEWEB)

    Strouse, P.J.; DiPietro, M.A.; Teo, E.L.H.J. [Section of Pediatric Radiology, University of Michigan Health System, Ann Arbor, MI (United States); Londy, F. [Division of Magnetic Resonance Imaging, Department of Radiology, University of Michigan Health System, Ann Arbor, MI (United States); Chrisp, C.E. [Unit of Laboratory Animal Medicine, University of Michigan Health System, Ann Arbor, MI (United States); Doi, K. [Division of Musculoskeletal Radiology, University of Michigan Health System, Ann Arbor, MI (United States)

    1999-05-01

    Background. Literature on magnetic resonance imaging (MR) evaluation of inflammatory joint effusions is sparse. Objective. To describe an animal model for studying infectious and non-infectious joint effusions with magnetic resonance imaging. Materials and methods. Ten rabbit knees with septic arthritis and four with talc synovitis were imaged with MR. Contralateral knees injected with saline served as controls. Fat saturation T2-weighted and gadolinium-enhanced T1-weighted images were assessed for joint effusion, and periarticular and adjacent intraosseous increased signal or enhancement. Each knee was cultured and underwent pathologic examination. Results. Both Staphylococcus aureus and talc produced effusions in all knees. The degree of periarticular signal and enhancement was greater in infected knees than talc-injected knees. No abnormal enhancement was seen within bone. Pathologic examination showed a greater degree of inflammation and joint destruction in the infected knees, but no evidence of osteomyelitis. Conclusion. A greater degree of abnormal signal and enhancement seen on MR suggests a more vigorous inflammatory process, as seen with septic arthritis. In spite of advanced septic arthritis, no enhancement was evident within bone, suggesting that enhancement within bone is not an expected finding in isolated septic arthritis and should raise concern for osteomyelitis. (orig.) With 3 figs., 15 refs.

  4. A buccal cell model comet assay: Development and evaluation for human biomonitoring and nutritional studies

    Energy Technology Data Exchange (ETDEWEB)

    Szeto, Y.T. [Department of Health Technology and Informatics, Hong Kong Polytechnic University, Kowloon, Hong Kong (China); School of Health Sciences, Macao Polytechnic Institute, Macao (China); Benzie, I.F.F. [Department of Health Technology and Informatics, Hong Kong Polytechnic University, Kowloon, Hong Kong (China)]. E-mail: iris.benzie@inet.polyu.edu.hk; Collins, A.R. [Department of Nutrition, University of Oslo, Oslo (Norway); Choi, S.W. [Department of Health Technology and Informatics, Hong Kong Polytechnic University, Kowloon, Hong Kong (China); Cheng, C.Y. [Department of Health Technology and Informatics, Hong Kong Polytechnic University, Kowloon, Hong Kong (China); Yow, C.M.N. [Department of Health Technology and Informatics, Hong Kong Polytechnic University, Kowloon, Hong Kong (China); Tse, M.M.Y. [School of Nursing, Hong Kong Polytechnic University, Kowloon, Hong Kong (China)

    2005-10-15

    The comet assay is a widely used biomonitoring tool for DNA damage. The most commonly used cells in human studies are lymphocytes. There is an urgent need to find an alternative target human cell that can be collected from normal subjects with minimal invasion. There are some reports of buccal cells, collected easily from the inside of the mouth, being used in studies of DNA damage and repair, and these were of interest. However, our preliminary studies following the published protocol showed that buccal cells sustained massive damage and disintegrated at the high pH [O. Ostling, K.J. Johanson. Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem. Biophys. Res. Commun. 123 (1984) 291-298] used, but that at lower pH were extremely resistant to lysis, an essential step in the comet assay. Therefore, the aims of this study were to develop a protocol than enabled buccal cell lysis and DNA damage testing in the comet assay, and to use the model to evaluate the potential use of the buccal cell model in human biomonitoring and nutritional study. Specifically, we aimed to investigate intra- and inter-individual differences in buccal cell DNA damage (as strand breaks), the effect of in vitro exposure to both a standard oxidant challenge and antioxidant treatment, as well as in situ exposure to an antioxidant-rich beverage and supplementation-related effects using a carotenoid-rich food. Successful lysis was achieved using 0.25% trypsin for 30 min followed by proteinase K (1 mg/ml) treatment for 60 min. When this procedure was performed on cells pre-embedded in agarose on a microscope slide, followed by electrophoresis (in 0.01 M NaOH, 1 mM EDTA, pH 9.1, 18 min at 12 V), a satisfactory comet image was obtained, though inter-individual variation was quite wide. Pre-lysis exposure of cells to a standard oxidant challenge (induced by H{sub 2}O{sub 2}) increased DNA strand breaks in a dose related manner, and incubation of cells in

  5. Blended Learning Analytics Model for Evaluation (BLAME. Et case-studie af universitetsunderviseres brug af Blackboard

    Directory of Open Access Journals (Sweden)

    Peter Musaeus

    2015-02-01

    Full Text Available I denne artikel vil vi præsentere en strategi til inddragelse af læringsanalytik (learning analytics ved evaluering af universitetsunderviseres brug af et nyt LMS på Aarhus Universitet: Blackboard. Vi diskuterer en model (BLAME: Blended Learning Analytics Model of Evaluation for, hvordan kategorisering af kurser og data om læringsanalytik indsamlet på Blackboard kan integreres. Endvidere belyser vi, hvilke implikationer en sådan læringsanalytik kan have for blended learning ved at analysere to forskellige uddannelses-cases/illustrationer. Dernæst diskuterer vi pædagogisk udvikling i forbindelse med evalueringsrapport om underviseres brug af Blackboard som beslutningsstøtte for feedback og pædagogisk intervention. Artiklen slutter med en diskussion af, hvordan data til læringsanalytik bør indsamles i LMS og bruges til afrapportering og undervisningsudvikling.

  6. Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models

    OpenAIRE

    Nguyen, Thu Thuy; Bazzoli, Caroline; Mentré, France

    2012-01-01

    International audience; Bioequivalence or interaction trials are commonly studied in crossover design and can be analysed by nonlinear mixed effects models as an alternative to noncompartmental approach. We propose an extension of the population Fisher information matrix in nonlinear mixed effects models to design crossover pharmacokinetic trials, using a linearisation of the model around the random effect expectation, including within-subject variability and discrete covariates fixed or chan...

  7. A modified rabbit ulna defect model for evaluating periosteal substitutes in bone engineering: a pilot study

    Directory of Open Access Journals (Sweden)

    Rania M El Backly

    2015-01-01

    Full Text Available The present work defines a modified critical size rabbit ulna defect model for bone regeneration in which a non-resorbable barrier membrane was used to separate the radius from the ulna to create a valid model for evaluation of tissue-engineered periosteal substitutes. Eight rabbits divided into two groups were used. Critical defects (15 mm were made in the ulna completely eliminating periosteum. For group I, defects were filled with a nanohydroxyapatite poly(ester urethane scaffold soaked in PBS and left as such (group Ia or wrapped with a tissue-engineered periosteal substitute (group Ib. For group II, an e-PTFE (GORE-TEX® membrane was inserted around the radius then the defects received either scaffold alone (group IIa or scaffold wrapped with periosteal substitute (group IIb. Animals were euthanized after 12-16 weeks, and bone regeneration was evaluated by radiography, computed microtomography (µCT, and histology. In the first group, we observed formation of radio-ulnar synostosis irrespective of the treatment. This was completely eliminated upon placement of the e-PTFE (GORE-TEX® membrane in the second group of animals. In conclusion, modification of the model using a non-resorbable e-PTFE membrane to isolate the ulna from the radius was a valuable addition allowing for objective evaluation of the tissue-engineered periosteal substitute.

  8. Career Development and Older Workers: Study Evaluating Adaptability in Older Workers Using Hall's Model

    Science.gov (United States)

    Strate, Merwyn L.; Torraco, Richard J.

    2005-01-01

    This qualitative case study described the development of adaptive competence in older workers using a Model of Adaptability and Adaptation developed by Dr. Douglas T. Hall (2002). Few studies have focused on the development of adaptability in workers when faced with change and no studies have focused on the development of adaptability in older…

  9. Forecasting DNI and GHI based on the WRF model. An evaluation study in Andalusia (Southern Spain)

    Energy Technology Data Exchange (ETDEWEB)

    Lara Fanego, Vicente; Ruiz Arias, Jose Antonio; Pozo Vazquez, Antonio David; Santos Alamillos, Francisco Javier; Tovar Pescador, Joaquin [Jaen Univ. (Spain). Dept. of Physics; Quesada Ruiz, Samuel [Jaen Univ. (Spain). Dept. of Computer Engineering

    2011-07-01

    In this work, we evaluate the reliability of GHI and DNI forecast based on the WRF mesoscale atmospheric model in Andalusia (Southern Spain). Particularly, the role of the spatial resolution of the model set up and the use of a spatial-averaging post-processing step was analyzed. To this end, a set of two-days-ahead one-year-length integrations, with different spatial resolutions (1, 3, 9 and 27 km) were evaluated. Results showed, firstly, that an increment in the spatial resolution does not enhance the reliability of the model forecasts, except under clear sky conditions. Secondly, that, in general, an spatial averaging of the solar forecasts corresponding to the grid points surrounding the location of interest provides a notable improvement in the forecasting skills. The most significant improvement is found when forecasts corresponding to an area of about 100 by 100 km are averaged. The role of the WRF model cloud representation in the former results is discussed. (orig.)

  10. CMAQ Model Evaluation Framework

    Science.gov (United States)

    CMAQ is tested to establish the modeling system’s credibility in predicting pollutants such as ozone and particulate matter. Evaluation of CMAQ has been designed to assess the model’s performance for specific time periods and for specific uses.

  11. Evaluation of Empirical Data and Modeling Studies to Support Soil Vapor Intrusion Screening Criteria for Petroleum Hydrocarbon Compounds

    Science.gov (United States)

    This study is an evaluation of empirical data and select modeling studies of the behavior of petroleum hydrocarbon (PHC) vapors in subsurface soils and how they can affect subsurface-to-indoor air vapor intrusion (VI), henceforth referred to as petroleum vapor intrusion or “PVI” ...

  12. Evaluation of unsaturated-zone solute-transport models for studies of agricultural chemicals

    Science.gov (United States)

    Nolan, Bernard T.; Bayless, E. Randall; Green, Christopher T.; Garg, Sheena; Voss, Frank D.; Lampe, David C.; Barbash, Jack E.; Capel, Paul D.; Bekins, Barbara A.

    2005-01-01

    Seven unsaturated-zone solute-transport models were tested with two data sets to select models for use by the Agricultural Chemical Team of the U.S. Geological Survey's National Water-Quality Assessment Program. The data sets were from a bromide tracer test near Merced, California, and an atrazine study in the White River Basin, Indiana. In this study the models are designated either as complex or simple based on the water flux algorithm. The complex models, HYDRUS2D, LEACHP, RZWQM, and VS2DT, use Richards' equation to simulate water flux and are well suited to process understanding. The simple models, CALF, GLEAMS, and PRZM, use a tipping-bucket algorithm and are more amenable to extrapolation because they require fewer input parameters. The purpose of this report is not to endorse a particular model, but to describe useful features, potential capabilities, and possible limitations that emerged from working with the model input data sets. More rigorous assessment of model applicability involves proper calibration, which was beyond the scope of this study.

  13. STUDY ON THE PERFORMANCE EVALUATION MODELS OF SMALL AND MEDIUM ENTERPRISES IN ROMANIA

    Directory of Open Access Journals (Sweden)

    Ionela-Carmen, PIRNEA

    2013-10-01

    Full Text Available In the current economic context, market by the globalization of the requirements of the European integration process, there is a growing interest in the business performance, so that they substantially improve their competitiveness in the European requirements. The paper highlights some of the results of a study conducted by the author in the doctoral program. One aim of this study was to determine the usability of business excellence models to assess the performance of small and medium enterprises in Romania. The research was conducted by the author in 2011-2012, in 173 small and medium enterprises in Romania. The research has shown that small and medium enterprises in Romania are concerned with the use of a business excellence model either Romanian or European model. Although uses a model of excellence in business, yet they meet certain criteria of the EFQM European Excellence Model.

  14. VPPA weld model evaluation

    Science.gov (United States)

    McCutcheon, Kimble D.; Gordon, Stephen S.; Thompson, Paul A.

    1992-07-01

    NASA uses the Variable Polarity Plasma Arc Welding (VPPAW) process extensively for fabrication of Space Shuttle External Tanks. This welding process has been in use at NASA since the late 1970's but the physics of the process have never been satisfactorily modeled and understood. In an attempt to advance the level of understanding of VPPAW, Dr. Arthur C. Nunes, Jr., (NASA) has developed a mathematical model of the process. The work described in this report evaluated and used two versions (level-0 and level-1) of Dr. Nunes' model, and a model derived by the University of Alabama at Huntsville (UAH) from Dr. Nunes' level-1 model. Two series of VPPAW experiments were done, using over 400 different combinations of welding parameters. Observations were made of VPPAW process behavior as a function of specific welding parameter changes. Data from these weld experiments was used to evaluate and suggest improvements to Dr. Nunes' model. Experimental data and correlations with the model were used to develop a multi-variable control algorithm for use with a future VPPAW controller. This algorithm is designed to control weld widths (both on the crown and root of the weld) based upon the weld parameters, base metal properties, and real-time observation of the crown width. The algorithm exhibited accuracy comparable to that of the weld width measurements for both aluminum and mild steel welds.

  15. An evaluation of behavior inferences from Bayesian state-space models: A case study with the Pacific walrus

    Science.gov (United States)

    Beatty, William; Jay, Chadwick V.; Fischbach, Anthony S.

    2016-01-01

    State-space models offer researchers an objective approach to modeling complex animal location data sets, and state-space model behavior classifications are often assumed to have a link to animal behavior. In this study, we evaluated the behavioral classification accuracy of a Bayesian state-space model in Pacific walruses using Argos satellite tags with sensors to detect animal behavior in real time. We fit a two-state discrete-time continuous-space Bayesian state-space model to data from 306 Pacific walruses tagged in the Chukchi Sea. We matched predicted locations and behaviors from the state-space model (resident, transient behavior) to true animal behavior (foraging, swimming, hauled out) and evaluated classification accuracy with kappa statistics (κ) and root mean square error (RMSE). In addition, we compared biased random bridge utilization distributions generated with resident behavior locations to true foraging behavior locations to evaluate differences in space use patterns. Results indicated that the two-state model fairly classified true animal behavior (0.06 ≤ κ ≤ 0.26, 0.49 ≤ RMSE ≤ 0.59). Kernel overlap metrics indicated utilization distributions generated with resident behavior locations were generally smaller than utilization distributions generated with true foraging behavior locations. Consequently, we encourage researchers to carefully examine parameters and priors associated with behaviors in state-space models, and reconcile these parameters with the study species and its expected behaviors.

  16. Evaluation and modeling of biochemical methane potential (BMP) of landfilled solid waste: a pilot scale study

    DEFF Research Database (Denmark)

    Bilgili, M Sinan; Demir, Ahmet; Varank, Gamze

    2009-01-01

    The main goal of this study was to present a comparison of landfill performance with respect to solids decomposition. Biochemical methane potential (BMP) test was used to determine the initial and the remaining CH(4) potentials of solid wastes during 27 months of landfilling operation in two pilot...... and R2 reactors were 0.01571 and 0.01195 1/d, respectively. The correlation between the model and the experimental parameters was more than 95%, showing the good fit of the model....

  17. Evaluation and analysis of urban public spaces using TOPSIS model (Case Study: Tabriz

    Directory of Open Access Journals (Sweden)

    M.R. Poormohammadi

    2013-01-01

    Full Text Available Extended abstract 1- IntroductionPublic spaces, which belong to all the individuals of different ages, occupations, cultures, and races with no restriction, are one of the most important parts in a city. Today, the importance of the studies on these spaces, considering the needs of the citizens, is more evident. Study and evaluation of urban public spaces, is an urgent necessity in planning the urban management and improvement, and it is a sign of the reproduction of these spaces which is done to improve the city in cultural, social and structural aspects. The approach to the study of these spaces includes 3 perspectives that are considered problems in literature related to urban society: a Surfaces or areas devoted to public occupancy: the discussion here is the fact that how much of the general net area is devoted to public occupancy. b Distribution of these spaces over the city: In this part, the dispersion and accumulation of each one of the public occupancies in a specific area, is compared to its standard ratio. The purpose of researching and studying urban public spaces (in this case, Tabriz is as follows: a Evaluation of quantitative status of public spaces in Tabriz; b Analyzing the settlement of public spaces in Tabriz and the dispersion of these areas; c Comparing the different public spaces in distinct regions of Tabriz; d Presenting required strategies to improve the general status of public spaces in Tabriz. The following research discusses these two assumptions: a There is a meaningful relationship between the area and per capita public space in Tabriz and the current existing standards of the country; b There is a meaningful difference between different regions of the city in terms of development. The research method in this study is descriptive-analytical. Statistical research population is the city of Tabriz which, based on the general pattern of the city, is divided into 9 urban areas. Evaluation of urban public spaces of the

  18. Evaluation of a Model-Based Hemodynamic Monitoring Method in a Porcine Study of Septic Shock

    Directory of Open Access Journals (Sweden)

    James A. Revie

    2013-01-01

    Full Text Available Introduction. The accuracy and clinical applicability of an improved model-based system for tracking hemodynamic changes is assessed in an animal study on septic shock. Methods. This study used cardiovascular measurements recorded during a porcine trial studying the efficacy of large-pore hemofiltration for treating septic shock. Four Pietrain pigs were instrumented and induced with septic shock. A subset of the measured data, representing clinically available measurements, was used to identify subject-specific cardiovascular models. These models were then validated against the remaining measurements. Results. The system accurately matched independent measures of left and right ventricle end diastolic volumes and maximum left and right ventricular pressures to percentage errors less than 20% (except for the 95th percentile error in maximum right ventricular pressure and all R2>0.76. An average decrease of 42% in systemic resistance, a main cardiovascular consequence of septic shock, was observed 120 minutes after the infusion of the endotoxin, consistent with experimentally measured trends. Moreover, modelled temporal trends in right ventricular end systolic elastance and afterload tracked changes in corresponding experimentally derived metrics. Conclusions. These results demonstrate that this model-based method can monitor disease-dependent changes in preload, afterload, and contractility in porcine study of septic shock.

  19. Quick evaluation of multiple geostatistical models using upscaling with coarse grids: A practical study

    Energy Technology Data Exchange (ETDEWEB)

    Lemouzy, P. [Institut Francais du Petrole and ELF/IFP Helios Group, Pau (France)

    1997-08-01

    In field delineation phase, uncertainty in hydrocarbon reservoir descriptions is large. To quickly examine the impact of this uncertainty on production performance, it is necessary to evaluate a large number of descriptions in relation to possible production methods (well spacing, injection rate, etc.). The method of using coarse upscaled models was first proposed by Ballin. Unlike other methods (connectivity analysis, tracer simulations), it considers parameters such as PVT, well management, etc. After a detailed review of upscaling issues, applications to water-injection cases (either with balance or imbalance of production, with or without aquifer) and to depletion of an oil reservoir with aquifer coning are presented. Much more important than the method of permeability upscaling far from wells, the need of correct upscaling of numerical well representation is pointed out Methods are proposed to accurately represent fluids volumes in coarse models. Simple methods to upscale relative permeabilities, and methods to efficiently correct numerical dispersion are proposed. Good results are obtained for water injection. The coarse upscaling method allows the performance of sensitivity analyses on model parameters at a much lower CPU cost than comprehensive simulations. Models representing extreme behaviors can be easily distinguished. For depletion of an oil reservoir showing aquifer coning, however, the method did not work property. It is our opinion that further research is required for upscaling close to wells. We therefore recombined this method for practical use in the case of water injection.

  20. Evaluation of soil flushing of complex contaminated soil: an experimental and modeling simulation study.

    Science.gov (United States)

    Yun, Sung Mi; Kang, Christina S; Kim, Jonghwa; Kim, Han S

    2015-04-28

    The removal of heavy metals (Zn and Pb) and heavy petroleum oils (HPOs) from a soil with complex contamination was examined by soil flushing. Desorption and transport behaviors of the complex contaminants were assessed by batch and continuous flow reactor experiments and through modeling simulations. Flushing a one-dimensional flow column packed with complex contaminated soil sequentially with citric acid then a surfactant resulted in the removal of 85.6% of Zn, 62% of Pb, and 31.6% of HPO. The desorption distribution coefficients, KUbatch and KLbatch, converged to constant values as Ce increased. An equilibrium model (ADR) and nonequilibrium models (TSNE and TRNE) were used to predict the desorption and transport of complex contaminants. The nonequilibrium models demonstrated better fits with the experimental values obtained from the column test than the equilibrium model. The ranges of KUbatch and KLbatch were very close to those of KUfit and KLfit determined from model simulations. The parameters (R, β, ω, α, and f) determined from model simulations were useful for characterizing the transport of contaminants within the soil matrix. The results of this study provide useful information for the operational parameters of the flushing process for soils with complex contamination.

  1. Model studies for evaluating the acute neurobehavioral effects of complex hydrocarbon solvents. I. Validation of methods with ethanol

    NARCIS (Netherlands)

    McKee, R.H.; Lammers, J.H.C.M.; Hoogendijk, E.M.G.; Emmen, H.H.; Muijser, H.; Barsotti, D.A.; Owen, D.E.; Kulig, B.M.

    2006-01-01

    As a preliminary step to evaluating the acute neurobehavioral effects of hydrocarbon solvents and to establish a working model for extrapolating animal test data to humans, joint neurobehavioral/toxicokinetic studies were conducted which involved administering ethanol to rats and volunteers. The spe

  2. Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models.

    Science.gov (United States)

    Nguyen, Thu Thuy; Bazzoli, Caroline; Mentré, France

    2012-05-20

    Bioequivalence or interaction trials are commonly studied in crossover design and can be analysed by nonlinear mixed effects models as an alternative to noncompartmental approach. We propose an extension of the population Fisher information matrix in nonlinear mixed effects models to design crossover pharmacokinetic trials, using a linearisation of the model around the random effect expectation, including within-subject variability and discrete covariates fixed or changing between periods. We use the expected standard errors of treatment effect to compute the power for the Wald test of comparison or equivalence and the number of subjects needed for a given power. We perform various simulations mimicking crossover two-period trials to show the relevance of these developments. We then apply these developments to design a crossover pharmacokinetic study of amoxicillin in piglets and implement them in the new version 3.2 of the r function PFIM.

  3. Evaluation of soil flushing of complex contaminated soil: An experimental and modeling simulation study

    Energy Technology Data Exchange (ETDEWEB)

    Yun, Sung Mi; Kang, Christina S. [Department of Environmental Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701 (Korea, Republic of); Kim, Jonghwa [Department of Industrial Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701 (Korea, Republic of); Kim, Han S., E-mail: hankim@konkuk.ac.kr [Department of Environmental Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701 (Korea, Republic of)

    2015-04-28

    Highlights: • Remediation of complex contaminated soil achieved by sequential soil flushing. • Removal of Zn, Pb, and heavy petroleum oils using 0.05 M citric acid and 2% SDS. • Unified desorption distribution coefficients modeled and experimentally determined. • Nonequilibrium models for the transport behavior of complex contaminants in soils. - Abstract: The removal of heavy metals (Zn and Pb) and heavy petroleum oils (HPOs) from a soil with complex contamination was examined by soil flushing. Desorption and transport behaviors of the complex contaminants were assessed by batch and continuous flow reactor experiments and through modeling simulations. Flushing a one-dimensional flow column packed with complex contaminated soil sequentially with citric acid then a surfactant resulted in the removal of 85.6% of Zn, 62% of Pb, and 31.6% of HPO. The desorption distribution coefficients, K{sub Ubatch} and K{sub Lbatch}, converged to constant values as C{sub e} increased. An equilibrium model (ADR) and nonequilibrium models (TSNE and TRNE) were used to predict the desorption and transport of complex contaminants. The nonequilibrium models demonstrated better fits with the experimental values obtained from the column test than the equilibrium model. The ranges of K{sub Ubatch} and K{sub Lbatch} were very close to those of K{sub Ufit} and K{sub Lfit} determined from model simulations. The parameters (R, β, ω, α, and f) determined from model simulations were useful for characterizing the transport of contaminants within the soil matrix. The results of this study provide useful information for the operational parameters of the flushing process for soils with complex contamination.

  4. Nondestructive evaluation of surface coating adhesion using model studies and ultrasonic goniometer experiments

    DEFF Research Database (Denmark)

    Hansen, Peder Bent; Jensen, Leif Bjørnø

    1989-01-01

    A general-purpose model for studying the reflection of acoustic plane waves or line-focused beams from a stratified medium is presented. Loss of adhesion between one or more pairs of layers is taken into account by assuming a partial layer tangential-displacement slip between the layers. Measurem...

  5. A Dispersion Model Evaluation Study for Real-Time Application in Complex Terrain.

    Science.gov (United States)

    Desiato, F.

    1991-08-01

    A few tracer experiments were carried out in autumn 1984 and summer 1985 at the Lago Brasimone site, on the Appennini Mountains approximately 50 km south of Bologna with the purpose assessing the atmospheric dispersion of pollutants under drainage flow conditions. The three-dimensional transport and diffusion model MATHEW/ADPIC (M/A) has been applied to selected tracer and meteorological data with the aim of assessing the model performance under complex terrain and meteorological conditions, and its sensitivity to input data available in real-time applications. Boundary layer input parameters were derived through standard algorithms based on tethersonde and pilot balloon measurements. Model simulations of the most significant tracer experiments have been assessed by means of several evaluation criteria, and the sensitivity to some input data has been investigated. The results show that if a limited spatial uncertainty in the computed concentration pattern is taken into account, M/A provides a good agreement with observed concentrations. The quality of the results is very sensitive to the presence of wind measurements where the deviation of the flow due to the shape of the valley is observed.

  6. Assessing the accuracy of tympanometric evaluation of external auditory canal volume: a scientific study using an ear canal model.

    Science.gov (United States)

    Al-Hussaini, A; Owens, D; Tomkinson, A

    2011-12-01

    Tympanometric evaluation is routinely used as part of the complete otological examination. During tympanometric examination, evaluation of middle ear pressure and ear canal volume is undertaken. Little is reported in relation to the accuracy and precision tympanometry evaluates external ear canal volume. This study examines the capability of the tympanometer to accurately evaluate external auditory canal volume in both simple and partially obstructed ear canal models and assesses its capability to be used in studies examining the effectiveness of cerumolytics. An ear canal model was designed using simple laboratory equipment, including a 5 ml calibrated clinical syringe (Becton Dickinson, Spain). The ear canal model was attached to the sensing probe of a Kamplex tympanometer (Interacoustics, Denmark). Three basic trials were undertaken: evaluation of the tympanometer in simple canal volume measurement, evaluation of the tympanometer in assessing canal volume with partial canal occlusion at different positions within the model, and evaluation of the tympanometer in assessing canal volume with varying degrees of canal occlusion. 1,290 individual test scenarios were completed over the three arms of the study. At volumes of 1.4 cm(3) or below, a perfect relationship was noted between the actual and tympanometric volumes in the simple model (Spearman's ρ = 1) with weakening degrees of agreement with increasing volume of the canal. Bland-Altman plotting confirmed the accuracy of this agreement. In the wax substitute models, tympanometry was observed to have a close relationship (Spearman's ρ > 0.99) with the actual volume present with worsening error above a volume of 1.4 cm(3). Bland-Altman plotting and precision calculations provided evidence of accuracy. Size and position of the wax substitute had no statistical effect on results [Wilcoxon rank-sum test (WRST) p > 0.99], nor did degree of partial obstruction (WRST p > 0.99). The Kamplex tympanometer

  7. Adsorption studies of molasse's wastewaters on activated carbon: modelling with a new fractal kinetic equation and evaluation of kinetic models.

    Science.gov (United States)

    Figaro, S; Avril, J P; Brouers, F; Ouensanga, A; Gaspard, S

    2009-01-30

    Adsorption kinetic of molasses wastewaters after anaerobic digestion (MSWD) and melanoidin respectively on activated carbon was studied at different pH. The kinetic parameters could be determined using classical kinetic equations and a recently published fractal kinetic equation. A linear form of this equation can also be used to fit adsorption data. Even with lower correlation coefficients the fractal kinetic equation gives lower normalized standard deviation values than the pseudo-second order model generally used to fit adsorption kinetic data, indicating that the fractal kinetic model is much more accurate for describing the kinetic adsorption data than the pseudo-second order kinetic model.

  8. Evaluation of E-Learners Behaviour using Different Fuzzy Clustering Models: A Comparative Study

    CERN Document Server

    Hogo, Mofreh A

    2010-01-01

    This paper introduces an evaluation methodologies for the e-learners' behaviour that will be a feedback to the decision makers in e-learning system. Learner's profile plays a crucial role in the evaluation process to improve the e-learning process performance. The work focuses on the clustering of the e-learners based on their behaviour into specific categories that represent the learner's profiles. The learners' classes named as regular, workers, casual, bad, and absent. The work may answer the question of how to return bad students to be regular ones. The work presented the use of different fuzzy clustering techniques as fuzzy c-means and kernelized fuzzy c-means to find the learners' categories and predict their profiles. The paper presents the main phases as data description, preparation, features selection, and the experiments design using different fuzzy clustering models. Analysis of the obtained results and comparison with the real world behavior of those learners proved that there is a match with per...

  9. Econometric Model Evaluation: Implications for Program Evaluation.

    Science.gov (United States)

    Ridge, Richard S.; And Others

    1990-01-01

    The problem associated with evaluating an econometric model using values outside those used in the model estimation is illustrated in the evaluations of a residential load management program during each of two successive years. Analysis reveals that attention must be paid to this problem. (Author/TJH)

  10. Fresh Kills leachate treatment and minimization study: Volume 2, Modeling, monitoring and evaluation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Fillos, J.; Khanbilvardi, R.

    1993-09-01

    The New York City Department of Sanitation is developing a comprehensive landfill leachate management plan for the Fresh Kills landfill, located on the western shore of Staten Island, New York. The 3000-acre facility, owned and operated by the City of New York, has been developed into four distinct mounds that correspond to areas designated as Sections 1/9, 2/8, 3/4 and 6/7. In developing a comprehensive leachate management plan, the estimating leachate flow rates is important in designing appropriate treatment alternatives to reduce the offsite migration that pollutes both surface water and groundwater resources.Estimating the leachate flow rates from Sections 1/9 and 6/7 was given priority using an available model, hydrologic evaluation of landfill performance (HELP), and a new model, flow investigation for landfill leachate (FILL). The field-scale analysis for leachate flow included data collection of the leachate mound-level from piezometers and monitoring wells installed on-site, for six months period. From the leachate mound-head contours and flow-gradients, Leachate flow rates were computed using Darcy`s Law.

  11. Modelling tunnel jet emissions with LASAT: evaluation study with two Austrian data sets (Ehrentalerbergtunnel and Kaisermuhlentunnel

    Directory of Open Access Journals (Sweden)

    Marcus Hirtl

    2011-02-01

    Full Text Available Two comprehensive data sets are used to investigate the ability of the Lagrangian particle diffusion model LASAT to simulate the dispersion of plumes emitted from tunnel jets. The data sets differ in traffic volume, tunnel geometry and temporal resolution of the measurement data. In the framework of the measurement campaign at the Ehrentalerbergtunnel in Carinthia, seven trace gas experiments with SF6 were conducted in 2001. Short term averages (30 minutes of concentrations were measured at 25 air quality stations in the vicinity of the tunnel portal during different meteorological conditions. In general the dispersion of the plume depends on the meteorological conditions (wind, stability and the modification of the flow by terrain and buildings in the vicinity of the portal. The influence of the exit velocity of the tunnel jet must also be considered as well as the difference between the exhaust temperature and the ambient air temperature to account for buoyancy effects. The temperature increment cannot be provided directly as input parameter to LASAT as in case of the tunnel jet velocity although it is an important parameter. With LASAT, the model user can adjust two empirical input parameters to the tunnel specifications. Relationships between these model parameters and the tunnel parameters are developed in this study. They are based on the data set Ehrentalerbergtunnel and provide reasonable input values for the model user. The simulations with LASAT show that the model is able to reproduce the location and the height of the observed peak concentrations very well. The second data set was generated from January to October 2001 at the Kaisermühlentunnel in Vienna. Measurements of NOx at four air quality stations near the portal are available. Because of uncertainties in the emission data caused by vehicle counts in only one direction, only long term averages of concentrations are compared for this data set. The functions between tunnel and

  12. Near-Surface Meteorology During the Arctic Summer Cloud Ocean Study (ASCOS): Evaluation of Reanalyses and Global Climate Models.

    Science.gov (United States)

    De Boer, G.; Shupe, M.D.; Caldwell, P.M.; Bauer, Susanne E.; Persson, O.; Boyle, J.S.; Kelley, M.; Klein, S.A.; Tjernstrom, M.

    2014-01-01

    Atmospheric measurements from the Arctic Summer Cloud Ocean Study (ASCOS) are used to evaluate the performance of three atmospheric reanalyses (European Centre for Medium Range Weather Forecasting (ECMWF)- Interim reanalysis, National Center for Environmental Prediction (NCEP)-National Center for Atmospheric Research (NCAR) reanalysis, and NCEP-DOE (Department of Energy) reanalysis) and two global climate models (CAM5 (Community Atmosphere Model 5) and NASA GISS (Goddard Institute for Space Studies) ModelE2) in simulation of the high Arctic environment. Quantities analyzed include near surface meteorological variables such as temperature, pressure, humidity and winds, surface-based estimates of cloud and precipitation properties, the surface energy budget, and lower atmospheric temperature structure. In general, the models perform well in simulating large-scale dynamical quantities such as pressure and winds. Near-surface temperature and lower atmospheric stability, along with surface energy budget terms, are not as well represented due largely to errors in simulation of cloud occurrence, phase and altitude. Additionally, a development version of CAM5, which features improved handling of cloud macro physics, has demonstrated to improve simulation of cloud properties and liquid water amount. The ASCOS period additionally provides an excellent example of the benefits gained by evaluating individual budget terms, rather than simply evaluating the net end product, with large compensating errors between individual surface energy budget terms that result in the best net energy budget.

  13. The evaluation of the diet/disease relation in the EPIC study: considerations for the calibration and the disease models

    DEFF Research Database (Denmark)

    Ferrari, Pietro; Day, Nicholas E; Boshuizen, Hendriek C;

    2008-01-01

    BACKGROUND: International multicentre studies on diet and cancer are relatively new in epidemiological research. They offer a series of challenging methodological issues for the evaluation of the association between dietary exposure and disease outcomes, which can both be quite heterogeneous across...... to the same reference scale. A linear regression calibration model was used to correct the association between diet and disease for measurement errors in dietary exposures. In the present work, we describe an approach for analysing the EPIC data, using as an example the evaluation of the association between...... (CI): 0.95-0.99] and 0.93 (0.88-0.98), before and after calibration, respectively. CONCLUSIONS: In a multicentre study, the diet/disease association can be evaluated by exploiting the whole variability of intake over the entire study. Calibration may reduce between-centre heterogeneity in the diet...

  14. Checklist for the qualitative evaluation of clinical studies with particular focus on external validity and model validity

    Directory of Open Access Journals (Sweden)

    Vollmar Horst C

    2006-12-01

    Full Text Available Abstract Background It is often stated that external validity is not sufficiently considered in the assessment of clinical studies. Although tools for its evaluation have been established, there is a lack of awareness of their significance and application. In this article, a comprehensive checklist is presented addressing these relevant criteria. Methods The checklist was developed by listing the most commonly used assessment criteria for clinical studies. Additionally, specific lists for individual applications were included. The categories of biases of internal validity (selection, performance, attrition and detection bias correspond to structural, treatment-related and observational differences between the test and control groups. Analogously, we have extended these categories to address external validity and model validity, regarding similarity between the study population/conditions and the general population/conditions related to structure, treatment and observation. Results A checklist is presented, in which the evaluation criteria concerning external validity and model validity are systemised and transformed into a questionnaire format. Conclusion The checklist presented in this article can be applied to both planning and evaluating of clinical studies. We encourage the prospective user to modify the checklists according to the respective application and research question. The higher expenditure needed for the evaluation of clinical studies in systematic reviews is justified, particularly in the light of the influential nature of their conclusions on therapeutic decisions and the creation of clinical guidelines.

  15. Fit-for-purpose: species distribution model performance depends on evaluation criteria - Dutch Hoverflies as a case study.

    Science.gov (United States)

    Aguirre-Gutiérrez, Jesús; Carvalheiro, Luísa G; Polce, Chiara; van Loon, E Emiel; Raes, Niels; Reemer, Menno; Biesmeijer, Jacobus C

    2013-01-01

    Understanding species distributions and the factors limiting them is an important topic in ecology and conservation, including in nature reserve selection and predicting climate change impacts. While Species Distribution Models (SDM) are the main tool used for these purposes, choosing the best SDM algorithm is not straightforward as these are plentiful and can be applied in many different ways. SDM are used mainly to gain insight in 1) overall species distributions, 2) their past-present-future probability of occurrence and/or 3) to understand their ecological niche limits (also referred to as ecological niche modelling). The fact that these three aims may require different models and outputs is, however, rarely considered and has not been evaluated consistently. Here we use data from a systematically sampled set of species occurrences to specifically test the performance of Species Distribution Models across several commonly used algorithms. Species range in distribution patterns from rare to common and from local to widespread. We compare overall model fit (representing species distribution), the accuracy of the predictions at multiple spatial scales, and the consistency in selection of environmental correlations all across multiple modelling runs. As expected, the choice of modelling algorithm determines model outcome. However, model quality depends not only on the algorithm, but also on the measure of model fit used and the scale at which it is used. Although model fit was higher for the consensus approach and Maxent, Maxent and GAM models were more consistent in estimating local occurrence, while RF and GBM showed higher consistency in environmental variables selection. Model outcomes diverged more for narrowly distributed species than for widespread species. We suggest that matching study aims with modelling approach is essential in Species Distribution Models, and provide suggestions how to do this for different modelling aims and species' data

  16. Fuzzy Model for Trust Evaluation

    Institute of Scientific and Technical Information of China (English)

    Zhang Shibin; He Dake

    2006-01-01

    Based on fuzzy set theory, a fuzzy trust model is established by using membership function to describe the fuzziness of trust. The trust vectors of subjective trust are obtained based on a mathematical model of fuzzy synthetic evaluation. Considering the complicated and changeable relationships between various subjects, the multi-level mathematical model of fuzzy synthetic evaluation is introduced. An example of a two-level fuzzy synthetic evaluation model confirms the feasibility of the multi-level fuzzy synthesis evaluation model. The proposed fuzzy model for trust evaluation may provide a promising method for research of trust model in open networks.

  17. A grey dynamic model for the evaluation of regional sustainable development and its emoirical study

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Currently,traditional development issues,such as economic stagnation,as well as new challenges like environmental degradation and globalization,need attention.Sustainable development,including economic,environmental,and social elements,is a main goal of decision-makers.The key to sustainable decision-making is to evaluate and forecast the status quo of sustainable development.Policy makers need a tool based on scientific information to forecast the effects of future actions on sustainability and make policies for sustainable development.This paper analyzes the relation of the economy,environment and social welfare by the grey dynamic model.The proposed method use time series and basic indicators of ecological system,including economic,environmental and social sub-systems.It is applied to Heilongfiang Province and Jiangsu Province.The results have proved different status quo of sustainable development in these two regions,and suggestions are proposed,such as optimization of industrial structure and eco-industrial development.The conclusion is that there is no unique sustainable path,and accordingly,policy makers shouM choose different criteria and strategies to make efficient sustainable decisions for each region.

  18. Physiologically based pharmacokinetic toolkit to evaluate environmental exposures: Applications of the dioxin model to study real life exposures.

    Science.gov (United States)

    Emond, Claude; Ruiz, Patricia; Mumtaz, Moiz

    2017-01-15

    Chlorinated dibenzo-p-dioxins (CDDs) are a series of mono- to octa-chlorinated homologous chemicals commonly referred to as polychlorinated dioxins. One of the most potent, well-known, and persistent member of this family is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). As part of translational research to make computerized models accessible to health risk assessors, we present a Berkeley Madonna recoded version of the human physiologically based pharmacokinetic (PBPK) model used by the U.S. Environmental Protection Agency (EPA) in the recent dioxin assessment. This model incorporates CYP1A2 induction, which is an important metabolic vector that drives dioxin distribution in the human body, and it uses a variable elimination half-life that is body burden dependent. To evaluate the model accuracy, the recoded model predictions were compared with those of the original published model. The simulations performed with the recoded model matched well with those of the original model. The recoded model was then applied to available data sets of real life exposure studies. The recoded model can describe acute and chronic exposures and can be useful for interpreting human biomonitoring data as part of an overall dioxin and/or dioxin-like compounds risk assessment. Copyright © 2016. Published by Elsevier Inc.

  19. Empirical Evaluation of the Proposed eXScrum Model: Results of a Case Study

    CERN Document Server

    Qureshi, M Rizwan Jameel

    2012-01-01

    Agile models promote fast development. XP and Scrum are the most widely used agile models. This paper investigates the phases of XP and Scrum models in order to identify their potentials and drawbacks. XP model has certain drawbacks, such as not suitable for maintenance projects and poor performance for medium and large-scale development projects. Scrum model has certain limitations, such as lacked in engineering practices. Since, both XP and Scrum models contain good features and strengths but still there are improvement possibilities in these models. Majority of the software development companies are reluctant to switch from traditional methodologies to agile methodologies for development of industrial projects. A fine integration, of software management of the Scrum model and engineering practices of XP model, is very much required to accumulate the strengths and remove the limitations of both models. This is achieved by proposing an eXScrum model. The proposed model is validated by conducting a controlled...

  20. Evaluation Theory, Models, and Applications

    Science.gov (United States)

    Stufflebeam, Daniel L.; Shinkfield, Anthony J.

    2007-01-01

    "Evaluation Theory, Models, and Applications" is designed for evaluators and students who need to develop a commanding knowledge of the evaluation field: its history, theory and standards, models and approaches, procedures, and inclusion of personnel as well as program evaluation. This important book shows how to choose from a growing…

  1. Evaluating the Framingham hypertension risk prediction model in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study.

    Science.gov (United States)

    Carson, April P; Lewis, Cora E; Jacobs, David R; Peralta, Carmen A; Steffen, Lyn M; Bower, Julie K; Person, Sharina D; Muntner, Paul

    2013-12-01

    A prediction model was developed in the Framingham Heart Study (FHS) to evaluate the short-term risk of hypertension. Our goal was to determine the predictive ability of the FHS hypertension model in a cohort of young adults advancing into middle age and compare it with the predictive ability of prehypertension and individual components of the FHS model. We studied 4388 participants, aged 18 to 30 years without hypertension at baseline, enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) Study, who participated in 2 consecutive examinations occurring 5 years apart between the baseline (1985-1986) and year 25 examination (2010-2011). Weibull regression was used to assess the association of the FHS model overall, individual components of the FHS model, and prehypertension with incident hypertension. During the 25-year follow-up period, 1179 participants developed incident hypertension. The FHS hypertension model (c-index=0.84; 95% confidence interval, 0.83-0.85) performed well in discriminating those who did and did not develop hypertension and was better than prehypertension alone (c-index=0.71; 95% confidence interval, 0.70-0.73). The predicted risk from the FHS hypertension model was systematically lower than the observed hypertension incidence initially (χ(2)=249.4; Padults with a high risk for developing hypertension.

  2. Nitrogen Management Evaluated by Models Combined with GIS-A Case Study of Jiangsu Croplands, China, in 2000

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The objective of this study is to provide scientific guidance for optimizing agricultural field nitrogen management that is based on the evaluation of current nitrogen application practice in Jiangsu Province, China, in 2000. The agricultural nitrogen models, consist of the soil mineralization model, the organic manure nitrogen releasing model, and the nitrogenous fertilizer use efficiency model. These models combined with the geographic information system technique were used to describe the spatial variability of nitrogen released from soil and organic manure and to identify its contributing factors. The comparison of the nitrogen fertilizer amount required by croplands, which was simulated by the models with the actual nitrogen fertilizer applied rate, was used to evaluate the current nitrogen application. The results showed that nitrogen was excessively applied in 71.8% croplands, given that the actual crop yield was desired. The excessive nitrogen amounted to 760 kiloton, accounting for 41.5% of the total nitrogen applied. Given that the actual highest yield was desired, nitrogen was reduced in 64.3% croplands. The total shortage of nitrogen was about 800 kiloton. Low use efficiency of nitrogen fertilizer was found in Taihu Lake area, Nanjing-Zhenjiang hilly area, and Xuzhou area, whereas the east beach area of Jiangsu showed an obvious deficiency of nitrogen fertilizer inputs. A balance of nitrogen fertilizer in Jiangsu croplands between excessive and deficient application areas would greatly benefit economic and environmental advantages.

  3. Parametric Study of Damage Evaluation into Solid Dielectrics Due to PD Activity Using a Kinetic Model

    Directory of Open Access Journals (Sweden)

    Alireza Ganjovi

    2014-09-01

    Full Text Available A kinetic model is used based on Particle in Cell - Monte Carlo Collision (PIC-MCC model, for parametric study of the damage due to partial discharges (PD activity into the surroundings dielectrics of a narrow channel encapsulated within the volume of a dielectric material. The parameters studied are applied electric field, channel dimensions and gas pressure. After employing an electric field across a dielectric material which contains a narrow channel, repeated ionization process starts in the gaseous medium of narrow channel. Charged particles, especially electrons, gain energy from the electric field across narrow channel and cause damage into dielectric surfaces of narrow channel on impact. The dependence of the electron energy distribution function (EEDF on the applied electric field is considered. These estimations are performed based on the number of C-H bond-scissions produced by the impacting electrons of a single PD pulse. Regarding this technique, the consequent damage into the solid dielectric and the time required to increase surface conductivity, is computed. The formation of acid molecules due to interaction of PD pulse with polymer surface in presence of air and humidity causes changes in the surface conductivity of the surrounding dielectrics of the narrow channels. It is observed that the extent of damage caused by a PD is primarily determined by the total number of impacting electrons which are capable of producing bond-scission at the dielectric. Parameters that effectively cause an increase in the number of energetic electrons will increase effective damage as well as surface conductivity of surrounding dielectrics.

  4. Near-surface meteorology during the Arctic Summer Cloud Ocean Study (ASCOS: evaluation of reanalyses and global climate models

    Directory of Open Access Journals (Sweden)

    G. de Boer

    2013-07-01

    Full Text Available Atmospheric measurements from the Arctic Summer Cloud Ocean Study (ASCOS are used to evaluate the performance of three reanalyses (ERA-Interim, NCEP/NCAR and NCEP/DOE and two global climate models (CAM5 and NASA GISS ModelE2 in simulation of the high Arctic environment. Quantities analyzed include near surface meteorological variables such as temperature, pressure, humidity and winds, surface-based estimates of cloud and precipitation properties, the surface energy budget, and lower atmospheric temperature structure. In general, the models perform well in simulating large scale dynamical quantities such as pressure and winds. Near-surface temperature and lower atmospheric stability, along with surface energy budget terms are not as well represented due largely to errors in simulation of cloud occurrence, phase and altitude. Additionally, a development version of CAM5, which features improved handling of cloud macro physics, is demonstrated to improve simulation of cloud properties and liquid water amount. The ASCOS period additionally provides an excellent example of the need to evaluate individual budget terms, rather than simply evaluating the net end product, with large compensating errors between individual surface energy budget terms resulting in the best net energy budget.

  5. Evaluating the governance model of hardware-dependent software ecosystems - a case study of the axis ecosystem

    DEFF Research Database (Denmark)

    Wnuk, Krzysztof; Manikas, Konstantinos; Runeson, Per

    2014-01-01

    specifically, we evaluate the governance model applied by Axis, a network video and surveillance camera producer, that is the platform owner and orchestrator of the Application Development Partner (ADP) software ecosystem. We conduct an exploratory case study collecting data from observations and interviews......Ecosystem governance becomes gradually more relevant for a set of companies or actors characterized by symbiotic relations evolved on the top of a technological platform, i.e. a software ecosystem. In this study, we focus on the governance of a hardware-dependent software ecosystem. More...... and apply the governance model for prevention and improvement of the software ecosystem health proposed by Jansen and Cusumano. Our results reveal that although the governance actions do not address the majority of their governance model, the ADP ecosystem is considered a growing ecosystem providing...

  6. Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Oxadiazole-Stilbene Hybrids against Phytopathogenic Fungi

    Science.gov (United States)

    Jian, Weilin; He, Daohang; Song, Shaoyun

    2016-08-01

    Natural stilbenes (especially resveratrol) play important roles in plant protection by acting as both constitutive and inducible defenses. However, their exogenous applications on crops as fungicidal agents are challenged by their oxidative degradation and limited availability. In this study, a new class of resveratrol-inspired oxadiazole-stilbene hybrids was synthesized via Wittig-Horner reaction. Bioassay results indicated that some of the compounds exhibited potent fungicidal activity against Botrytis cinerea in vitro. Among these stilbene hybrids, compounds 11 showed promising inhibitory activity with the EC50 value of 144.6 μg/mL, which was superior to that of resveratrol (315.6 μg/mL). Remarkably, the considerably abnormal mycelial morphology was observed in the presence of compound 11. The inhibitory profile was further proposed by homology modeling and molecular docking studies, which showed the possible interaction of resveratrol and oxadiazole-stilbene hybrids with the cytochrome P450-dependent sterol 14α-demethylase from B. cinerea (BcCYP51) for the first time. Taken together, these results would provide new insights into the fungicidal mechanism of stilbenes, as well as an important clue for biology-oriented synthesis of stilbene hybrids with improved bioactivity against plant pathogenic fungi in crop protection.

  7. Using Visual Analysis to Evaluate and Refine Multilevel Models of Single-Case Studies

    Science.gov (United States)

    Baek, Eun Kyeng; Petit-Bois, Merlande; Van den Noortgate, Wim; Beretvas, S. Natasha; Ferron, John M.

    2016-01-01

    In special education, multilevel models of single-case research have been used as a method of estimating treatment effects over time and across individuals. Although multilevel models can accurately summarize the effect, it is known that if the model is misspecified, inferences about the effects can be biased. Concern with the potential for model…

  8. Evaluation of half-bridge modular multilevel converter model for VSC-HVDC transient stability studies

    DEFF Research Database (Denmark)

    Irnawan, Roni; Silva, Filipe Miguel Faria da; Bak, Claus Leth

    2017-01-01

    is described. This RMS model is then simplified by neglecting the inner/current controller. Both detailed and simplified RMS models are then validated against an accurate electromagnetic (EMT) transient model in a point-to-point (PtP) transmission system with different AC network strength, power directions...

  9. Prospects of ratio and differential ({\\delta}) ratio based measurement-models: a case study for IRMS evaluation

    CERN Document Server

    Datta, B P

    2015-01-01

    The suitability of a mathematical-model Y = f({Xi}) in serving a purpose whatsoever (should be preset by the function f specific input-to-output variation-rates, i.e.) can be judged beforehand. We thus evaluate here the two apparently similar models: YA = fA(SRi,WRi) = (SRi/WRi) and: YD = fd(SRi,WRi) = ([SRi,WRi] - 1) = (YA - 1), with SRi and WRi representing certain measurable-variables (e.g. the sample S and the working-lab-reference W specific ith-isotopic-abundance-ratios, respectively, for a case as the isotope ratio mass spectrometry (IRMS)). The idea is to ascertain whether fD should represent a better model than fA, specifically, for the well-known IRMS evaluation. The study clarifies that fA and fD should really represent different model-families. For example, the possible variation, eA, of an absolute estimate as the yA (and/ or the risk of running a machine on the basis of the measurement-model fA) should be dictated by the possible Ri-measurement-variations (u_S and u_W) only: eA = (u_S + u_W); i....

  10. Second order closure integrated puff (SCIPUFF) model verification and evaluation study. Technical memo

    Energy Technology Data Exchange (ETDEWEB)

    Nappo, C.J.; Eckman, R.M.; Rao, K.S.; Herwehe, J.A.; Gunter, L.

    1998-06-01

    This report summarizes a verification of the SCIPUFF model as descried in the draft report PC-SCIPUFF Version 0.2 Technical Documentation by Sykes et al. The verification included a scientific review of the model physics and parameterizations described in the report, and checks for their internal usage and consistency with current practices in atmospheric dispersion modeling. This work is intended to examine the scientific basis and defensiblity of the model for the intended application. A related task is an assessment of the model`s general capabilities and limitations. A line-by-line verification of the computer source code was not possible; however, the code was checked with a commercial code analyzer. About 47 potential coding inconsistencies were identified.

  11. Comparison of Fuzzy AHP Buckley and ANP Models in Forestry Capability Evaluation (Case Study: Behbahan City Fringe

    Directory of Open Access Journals (Sweden)

    V. Rahimi

    2015-12-01

    Full Text Available The area of Zagros forests is continuously in danger of destruction. Therefore, the remaining forests should be carefully managed based on ecological capability evaluation. In fact, land evaluation includes prediction or assessment of land quality for a special land use with regard to production, vulnerability and management requirements. In this research, we studied the ecological capability of Behbahan city fringe for forestry land use. After the basic studies were completed and the thematic maps such as soil criteria, climate, physiography, vegetation and bedrock were prepared, the fuzzy multi-criteria decision-making methods of Fuzzy AHP Buckley and ANP were used to standardize and determine the weights of criteria. Finally, the ecological model of the region’s capability was generated to prioritize forestry land use and prepare the final map of evaluation using WLC model in seven classes. The results showed that in ANP method, 55.58% of the area is suitable for forestry land use which is more consistent with the reality, while in the Fuzzy AHP method, 95.23% of the area was found suitable. Finally, it was concluded that the ANP method shows more flexibility and ability to determine suitable areas for forestry land use in the study area.

  12. Bayesian model averaging method for evaluating associations between air pollution and respiratory mortality: a time-series study

    Science.gov (United States)

    Fang, Xin; Li, Runkui; Kan, Haidong; Bottai, Matteo; Fang, Fang

    2016-01-01

    Objective To demonstrate an application of Bayesian model averaging (BMA) with generalised additive mixed models (GAMM) and provide a novel modelling technique to assess the association between inhalable coarse particles (PM10) and respiratory mortality in time-series studies. Design A time-series study using regional death registry between 2009 and 2010. Setting 8 districts in a large metropolitan area in Northern China. Participants 9559 permanent residents of the 8 districts who died of respiratory diseases between 2009 and 2010. Main outcome measures Per cent increase in daily respiratory mortality rate (MR) per interquartile range (IQR) increase of PM10 concentration and corresponding 95% confidence interval (CI) in single-pollutant and multipollutant (including NOx, CO) models. Results The Bayesian model averaged GAMM (GAMM+BMA) and the optimal GAMM of PM10, multipollutants and principal components (PCs) of multipollutants showed comparable results for the effect of PM10 on daily respiratory MR, that is, one IQR increase in PM10 concentration corresponded to 1.38% vs 1.39%, 1.81% vs 1.83% and 0.87% vs 0.88% increase, respectively, in daily respiratory MR. However, GAMM+BMA gave slightly but noticeable wider CIs for the single-pollutant model (−1.09 to 4.28 vs −1.08 to 3.93) and the PCs-based model (−2.23 to 4.07 vs −2.03 vs 3.88). The CIs of the multiple-pollutant model from two methods are similar, that is, −1.12 to 4.85 versus −1.11 versus 4.83. Conclusions The BMA method may represent a useful tool for modelling uncertainty in time-series studies when evaluating the effect of air pollution on fatal health outcomes. PMID:27531727

  13. An economic evaluation for prevention of diabetes mellitus in a developing country: a modelling study.

    Science.gov (United States)

    Liu, Xiaoqian; Li, Changping; Gong, Hui; Cui, Zhuang; Fan, Linlin; Yu, Wenhua; Zhang, Cui; Ma, Jun

    2013-08-07

    The serious consequences of diabetes mellitus, and the subsequent economic burden, call for urgent preventative action in developing countries. This study explores the clinical and economic outcomes of strategies that could potentially prevent diabetes based on Chinese circumstances. It aims to provide indicators for the long-term allocation of healthcare resources for authorities in developing countries. A representative sample of Chinese adults was used to create a simulated population of 20,000 people aged 25 years and above. The hybrid decision tree Markov model was developed to compare the long-term clinical and economic outcomes of four simulated diabetes prevention strategies with a control group, where no prevention applied. These preventive strategies were the following: (i) one-off screening for undiagnosed diabetes and impaired glucose tolerance (IGT), with lifestyle interventions on diet, (ii) on exercise, (iii) on diet combined exercise (duo-intervention) respectively in those with IGT, and (iv) one-off screening alone. Independent age-specific models were simulated based on diverse incidences of diabetes, mortalities and health utilities. The reported outcomes were the following: the remaining survival years, the quality-adjusted life years (QALYs) per diabetes or IGT subjects, societal costs per simulated subject and the comparisons between preventions and control over 40 years. Sensitivity analyses were performed based on variations of all assumptions, in addition to the performance and the compliance of screening. Compared with the control group, all simulated screening programmes prolonged life expectancy at the initiation ages of 25 and 40 years, postponed the onset of diabetes and increased QALYs at every initiation age. Along with an assumption of six years intervention, prevention programmes were associated with cost-saving compared with the control group, especially in the population aged 25 years. The savings were at least US$2017 per

  14. Equivocality in IS/IT Project Evaluation: Model Development and Pilot Study

    NARCIS (Netherlands)

    Arviansyah, A.; Spil, Antonius A.M.; van Hillegersberg, Jos

    2014-01-01

    IS/IT projects are perceived as ventures which are prone to failure and may lead to disruptive conditions. Evaluating the continuation of projects is highly important for stakeholders and decision makers. However, this event is hampered by the problem of equivocality. The main objective of this

  15. Evaluating the effectiveness of Neuro web design model in business websites (observational study)

    National Research Council Canada - National Science Library

    Boshra Sedghi Shamir; Seyyed Ali Akbar Ahmadi

    2016-01-01

    .... The practical Neuro business web design model consists of 67 applicable and implementable techniques in business websites and has been gathered in three sequential phases: attraction، message delivery...

  16. The daytime boundary layer in the Inn Valley - A model evaluation study with high-quality turbulence measurements

    Science.gov (United States)

    Goger, Brigitta; Rotach, Mathias W.; Gohm, Alexander; Fuhrer, Oliver; Stiperski, Ivana

    2016-04-01

    Atmospheric processes associated with complex terrain include various phenomena on the meso- and microscale, which contribute significantly to the local weather in mountainous areas of the Earth. One of the most prominent and well-known boundary-layer phenomena in mountainous terrain is the daytime valley wind circulation, which is very pronounced on clear-sky days with weak synoptic forcing. We use several chosen "valley wind days" in the Inn Valley, Austria, as case studies for the evaluation of the performance of the NWP model COSMO on a horizontal resolution of 1.1 km with a focus on boundary-layer processes and turbulent exchange. The overall goal is to evaluate the model setup and to investigate whether the model's physics schemes (initially developed for horizontally homogeneous and flat surroundings) are suitable for truly complex terrain. We evaluate the model by using measurements from the so-called "i-Box" located in the Inn Valley. The i-Box consists of six core sites that are located at representative locations in the Inn Valley, and two remote sensing systems (wind Lidar and HATPRO passive T/RH profiler) in the city of Innsbruck. The long-term data set provides a data pool of high-resolution velocity variances, turbulence variables, radiation, soil moisture, and vertical profiles of temperature, humidity, and wind in the lower troposphere, which allows a process-oriented analysis. A special focus is laid on the daytime valley boundary layer and its interaction with the developing up-valley wind. Vertical cross-sections show that the valley wind has an asymmetric structure, hence, the i-Box stations show a high spatial variability. While the station on the valley bottom and on the south-facing slope are clearly under the strong influence of the valley wind, the two stations on the north-facing slope are rather dominated by slope flows. We find that the valley wind has a strong (indirect) influence on the development of the local turbulence kinetic

  17. Performance Evaluation of Linear (ARMA and Threshold Nonlinear (TAR Time Series Models in Daily River Flow Modeling (Case Study: Upstream Basin Rivers of Zarrineh Roud Dam

    Directory of Open Access Journals (Sweden)

    Farshad Fathian

    2017-01-01

    (2 years were chosen for validation, subjectively. As data have seasonal cycles, statistical indices (such as mean and standard deviation of daily discharge were estimated using Fourier series. Then ARMA and two- and three-regime SETAR models applied to the standardized daily river flow time series. Some performance criteria were used to evaluate the models accuracy. In other words, in this paper, linear and non-linear models such as ARMA and two- and three-regime SETAR models were fitted to observed river flows. The parameters associated to the models, e.g. the threshold value for the SETAR model was estimated. Finally, the fitted linear and non-linear models were selected using the Akaike Information Criterion (AIC, Root Mean Square (RMSE and Sum of Squared Residuals (SSR criteria. In order to check the adequacy of the fitted models the Ljung-Box test was used. Results and Discussion: To a certain degree the result of the river flow data of study area indicates that the threshold models may be appropriate for modeling and forecasting the streamflows of rivers located in the upstream part of Zarrineh Roud dam. According to the obtained evaluation criteria of fitted models, it can be concluded the performance of two- and three- regime SETAR models are slightly better than the ARMA model in all selected stations. As well as, modeling and comparison of SETAR models showed that the three-regime SETAR model have evaluation criteria better than two-regime SETAR model in all stations except Ghabghablou station. Conclusion: In the present study, we attempted to model daily streamflows of Zarrineh Rood Basin Rivers located in the south of Urmia Lake by applying ARMA and two- and three-regime SETAR models. This is mainly because very few efforts and rather less attention have been paid to this non-linear approach in hydrology and water resources engineering generally. Therefore, two types of data-driven models were used for modeling and forecasting daily streamflow: (i

  18. Evaluation Model of System Survivability

    Institute of Scientific and Technical Information of China (English)

    LIU Yuling; PAN Shiying; TIAN Junfeng

    2006-01-01

    This paper puts forward a survivability evaluation model, SQEM(Survivability Quantitative Evaluation Model), based on lucubrating the main method existed. Then it defines the measurement factors and parses the survivability mathematically, introduces state change probability and the idea of setting the weights of survivability factors dynamically into the evaluating process of SQEM, which improved the accuracy of evaluation. An example is presented to illustrate the way SQEM works, which demonstrated the validity and feasibility of the method.

  19. A general framework for the evaluation of genetic association studies using multiple marginal models

    DEFF Research Database (Denmark)

    Kitsche, Andreas; Ritz, Christian; Hothorn, Ludwig A.

    2016-01-01

    is that no explicit formulation of the correlation between the test statistics is required. Moreover, the genotype scores are considered as a quantitative explanatory variable, i.e., regression models are used. RESULTS: The proposed approach covers a wide variety of endpoints (binary, count, quantitative, and time-to-event...

  20. Evaluation of Mouse Wound Models for Probiotics-Based Wound Infection Prevention Study

    Science.gov (United States)

    2016-06-01

    beneficial effect in limiting Streptococcus pyogenes infection. 15. SUBJECT TERMS Infection, antibiotics , probiotics, wounds, murine wound model...AND METHODS ......................................................................................... 2 3.1 Animals ...release. Distribution is unlimited. Cleared, 88PA, Case # 2016-4002, 16 Aug 2016. 1.0 SUMMARY Despite the wide use of antibiotics in trauma care

  1. Combining dendrochronology and matrix modelling in demographic studies: An evaluation for Juniperus procera in Ethiopia

    NARCIS (Netherlands)

    Couralet, C.; Sass, U.G.W.; Sterck, F.J.; Zuidema, P.A.

    2005-01-01

    Tree demography was analysed by applying dendrochronological techniques and matrix modelling on a static data set of Juniperus procera populations of Ethiopian dry highland forests. Six permanent sample plots were established for an inventory of diameters and 11 stem discs were collected for

  2. Study of Interdigitated Electrode Arrays Using Experiments and Finite Element Models for the Evaluation of Sterilization Processes

    Directory of Open Access Journals (Sweden)

    Jan Oberländer

    2015-10-01

    Full Text Available In this work, a sensor to evaluate sterilization processes with hydrogen peroxide vapor has been characterized. Experimental, analytical and numerical methods were applied to evaluate and study the sensor behavior. The sensor set-up is based on planar interdigitated electrodes. The interdigitated electrode structure consists of 614 electrode fingers spanning over a total sensing area of 20 mm2. Sensor measurements were conducted with and without microbiological spores as well as after an industrial sterilization protocol. The measurements were verified using an analytical expression based on a first-order elliptical integral. A model based on the finite element method with periodic boundary conditions in two dimensions was developed and utilized to validate the experimental findings.

  3. Study of interdigitated electrode arrays using experiments and finite element models for the evaluation of sterilization processes.

    Science.gov (United States)

    Oberländer, Jan; Jildeh, Zaid B; Kirchner, Patrick; Wendeler, Luisa; Bromm, Alexander; Iken, Heiko; Wagner, Patrick; Keusgen, Michael; Schöning, Michael J

    2015-10-14

    In this work, a sensor to evaluate sterilization processes with hydrogen peroxide vapor has been characterized. Experimental, analytical and numerical methods were applied to evaluate and study the sensor behavior. The sensor set-up is based on planar interdigitated electrodes. The interdigitated electrode structure consists of 614 electrode fingers spanning over a total sensing area of 20 mm². Sensor measurements were conducted with and without microbiological spores as well as after an industrial sterilization protocol. The measurements were verified using an analytical expression based on a first-order elliptical integral. A model based on the finite element method with periodic boundary conditions in two dimensions was developed and utilized to validate the experimental findings.

  4. Evaluating cloud processes in large-scale models: Of idealized case studies, parameterization testbeds and single-column modelling on climate time-scales

    Science.gov (United States)

    Neggers, Roel

    2016-04-01

    Boundary-layer schemes have always formed an integral part of General Circulation Models (GCMs) used for numerical weather and climate prediction. The spatial and temporal scales associated with boundary-layer processes and clouds are typically much smaller than those at which GCMs are discretized, which makes their representation through parameterization a necessity. The need for generally applicable boundary-layer parameterizations has motivated many scientific studies, which in effect has created its own active research field in the atmospheric sciences. Of particular interest has been the evaluation of boundary-layer schemes at "process-level". This means that parameterized physics are studied in isolated mode from the larger-scale circulation, using prescribed forcings and excluding any upscale interaction. Although feedbacks are thus prevented, the benefit is an enhanced model transparency, which might aid an investigator in identifying model errors and understanding model behavior. The popularity and success of the process-level approach is demonstrated by the many past and ongoing model inter-comparison studies that have been organized by initiatives such as GCSS/GASS. A red line in the results of these studies is that although most schemes somehow manage to capture first-order aspects of boundary layer cloud fields, there certainly remains room for improvement in many areas. Only too often are boundary layer parameterizations still found to be at the heart of problems in large-scale models, negatively affecting forecast skills of NWP models or causing uncertainty in numerical predictions of future climate. How to break this parameterization "deadlock" remains an open problem. This presentation attempts to give an overview of the various existing methods for the process-level evaluation of boundary-layer physics in large-scale models. This includes i) idealized case studies, ii) longer-term evaluation at permanent meteorological sites (the testbed approach

  5. A study on the minimum number of loci required for genetic evaluation using a finite locus model

    Directory of Open Access Journals (Sweden)

    Fernando Rohan L

    2004-07-01

    Full Text Available Abstract For a finite locus model, Markov chain Monte Carlo (MCMC methods can be used to estimate the conditional mean of genotypic values given phenotypes, which is also known as the best predictor (BP. When computationally feasible, this type of genetic prediction provides an elegant solution to the problem of genetic evaluation under non-additive inheritance, especially for crossbred data. Successful application of MCMC methods for genetic evaluation using finite locus models depends, among other factors, on the number of loci assumed in the model. The effect of the assumed number of loci on evaluations obtained by BP was investigated using data simulated with about 100 loci. For several small pedigrees, genetic evaluations obtained by best linear prediction (BLP were compared to genetic evaluations obtained by BP. For BLP evaluation, used here as the standard of comparison, only the first and second moments of the joint distribution of the genotypic and phenotypic values must be known. These moments were calculated from the gene frequencies and genotypic effects used in the simulation model. BP evaluation requires the complete distribution to be known. For each model used for BP evaluation, the gene frequencies and genotypic effects, which completely specify the required distribution, were derived such that the genotypic mean, the additive variance, and the dominance variance were the same as in the simulation model. For lowly heritable traits, evaluations obtained by BP under models with up to three loci closely matched the evaluations obtained by BLP for both purebred and crossbred data. For highly heritable traits, models with up to six loci were needed to match the evaluations obtained by BLP.

  6. Differential program evaluation model in child protection.

    Science.gov (United States)

    Lalayants, Marina

    2012-01-01

    Increasingly attention has been focused to the degree to which social programs have effectively and efficiently delivered services. Using the differential program evaluation model by Tripodi, Fellin, and Epstein (1978) and by Bielawski and Epstein (1984), this paper described the application of this model to evaluating a multidisciplinary clinical consultation practice in child protection. This paper discussed the uses of the model by demonstrating them through the four stages of program initiation, contact, implementation, and stabilization. This organizational case study made a contribution to the model by introducing essential and interrelated elements of a "practical evaluation" methodology in evaluating social programs, such as a participatory evaluation approach; learning, empowerment and sustainability; and a flexible individualized approach to evaluation. The study results demonstrated that by applying the program development model, child-protective administrators and practitioners were able to evaluate the existing practices and recognize areas for program improvement.

  7. Evaluation of nutrition models to estimate performance of young dairy calves: a meta-analytical study under tropical conditions.

    Science.gov (United States)

    Souza, V L; Drackley, J K; Almeida, R; Bittar, C M M; Albertini, T Z; Morrison, S Y; Lanna, D P D

    2016-12-01

    Mathematical models are important tools to estimate nutritional requirements and animal growth. Very few calf models generated from other countries with different feeding programs, environment and production systems have been evaluated. The objective of this paper is to evaluate two calf models: (i) the National Research Council (NRC) in 2001 and (ii) the updates published by Van Amburgh and Drackley in 2005 and inputted into Agricultural Modeling and Training Systems (AMTS, version 3.5.8). Data from 16 previous studies involving 51 diets for dairy calves under tropical conditions (n=485 calves, initial BW 37.5±4.35 kg and weaning weight of 62.0±10.16 kg) were used. The calves were fed with whole milk, milk replacer or fermented colostrum, plus starter (20.9±1.78% of CP). The accuracy of the average daily gain (ADG) prediction was evaluated by mean bias, mean square prediction error (MSPE), concordance correlation coefficient, bias correction factor (Cb), and regression between the observed and predicted values. The ADG observed from birth to weaning was 0.452±0.121 kg/day. Calves fed with whole milk had greater ADG compared with calves fed milk replacer (0.477 v. 0.379 kg/day) during the milk-feeding period. When all data were pooled (n=51 diets), predictions had a mean bias of -0.019 and 0.068 kg/day for energy-allowable gain using NRC and AMTS models, respectively. The regression equation between observed and predicted values obtained from energy of diets showed an intercept different from zero (P0.05) indicate that the AMTS growth model resulted in accurate predictions for calves fed with milk replacer. However, within these latter two approaches, the goodness of fit (R 2) was low, representing low precision. The weight gain estimated by the energy available from the diet was overestimated by 19 g/day when calculated by the NRC and underestimated by 68 g/day when calculated by AMTS. The reasons for this discrepancy need to be understood, for only then new

  8. Doppler echo evaluation of pulmonary venous-left atrial pressure gradients: human and numerical model studies

    Science.gov (United States)

    Firstenberg, M. S.; Greenberg, N. L.; Smedira, N. G.; Prior, D. L.; Scalia, G. M.; Thomas, J. D.; Garcia, M. J.

    2000-01-01

    The simplified Bernoulli equation relates fluid convective energy derived from flow velocities to a pressure gradient and is commonly used in clinical echocardiography to determine pressure differences across stenotic orifices. Its application to pulmonary venous flow has not been described in humans. Twelve patients undergoing cardiac surgery had simultaneous high-fidelity pulmonary venous and left atrial pressure measurements and pulmonary venous pulsed Doppler echocardiography performed. Convective gradients for the systolic (S), diastolic (D), and atrial reversal (AR) phases of pulmonary venous flow were determined using the simplified Bernoulli equation and correlated with measured actual pressure differences. A linear relationship was observed between the convective (y) and actual (x) pressure differences for the S (y = 0.23x + 0.0074, r = 0.82) and D (y = 0.22x + 0.092, r = 0.81) waves, but not for the AR wave (y = 0. 030x + 0.13, r = 0.10). Numerical modeling resulted in similar slopes for the S (y = 0.200x - 0.127, r = 0.97), D (y = 0.247x - 0. 354, r = 0.99), and AR (y = 0.087x - 0.083, r = 0.96) waves. Consistent with numerical modeling, the convective term strongly correlates with but significantly underestimates actual gradient because of large inertial forces.

  9. Tools for Model Evaluation

    DEFF Research Database (Denmark)

    Olesen, H. R.

    1998-01-01

    Proceedings of the Twenty-Second NATO/CCMS International Technical Meeting on Air Pollution Modeling and Its Application, held June 6-10, 1997, in Clermont-Ferrand, France.......Proceedings of the Twenty-Second NATO/CCMS International Technical Meeting on Air Pollution Modeling and Its Application, held June 6-10, 1997, in Clermont-Ferrand, France....

  10. Evaluating the mindfulness-based coping program: an effectiveness study using a mixed model approach

    Directory of Open Access Journals (Sweden)

    Edvin Bru

    2012-01-01

    Full Text Available Since more than 450 million people worldwide suffer from mental disorders, interventions that promote mental health have been called for. Mindfulness-based coping (MBC is an intervention based on coping skills from cognitive behavioral therapy integrating mindfulness practices. The aim of this study was to examine the effectiveness of the MBC program for psychiatric outpatients. The study employed a mixed research method with a qualitative approach using semi-structured patient interviews and clinical assessments from patients’ therapists and a quantitative approach using instruments measuring mindful coping, mental ill health, and life satisfaction. The study sample included 38 psychiatric outpatients from a district psychiatric outpatient service in Norway. Results suggested that although use of the different skills varied, participants had a positive experience with the program and positive changes in psychological functioning were observed. Findings provide knowledge regarding the design of interventions integrating mindfulness to promote more adequate psychological coping.

  11. Evaluating Teleworkers' Acceptance of Mobile Technology: A Study Based on the Utaut Model

    Science.gov (United States)

    Mills, Jamia Sharie

    2016-01-01

    Mobile technology has provided flexible methods for employees to complete work-related tasks without being tied to an office. Research has predicted the level of training on mobile technology may impact a user's ability to complete work responsibilities accurately. This study intended to examine what behavior factors from the unified theory of…

  12. Combating unmeasured confounding in cross-sectional studies: evaluating instrumental-variable and Heckman selection models.

    Science.gov (United States)

    DeMaris, Alfred

    2014-09-01

    Unmeasured confounding is the principal threat to unbiased estimation of treatment "effects" (i.e., regression parameters for binary regressors) in nonexperimental research. It refers to unmeasured characteristics of individuals that lead them both to be in a particular "treatment" category and to register higher or lower values than others on a response variable. In this article, I introduce readers to 2 econometric techniques designed to control the problem, with a particular emphasis on the Heckman selection model (HSM). Both techniques can be used with only cross-sectional data. Using a Monte Carlo experiment, I compare the performance of instrumental-variable regression (IVR) and HSM to that of ordinary least squares (OLS) under conditions with treatment and unmeasured confounding both present and absent. I find HSM generally to outperform IVR with respect to mean-square-error of treatment estimates, as well as power for detecting either a treatment effect or unobserved confounding. However, both HSM and IVR require a large sample to be fully effective. The use of HSM and IVR in tandem with OLS to untangle unobserved confounding bias in cross-sectional data is further demonstrated with an empirical application. Using data from the 2006-2010 General Social Survey (National Opinion Research Center, 2014), I examine the association between being married and subjective well-being.

  13. Maritime Platform Sleep and Performance Study: Evaluating the SAFTE Model for Maritime Workplace Application

    Science.gov (United States)

    2012-06-01

    Finally, 60% of the participants reported requiring one or more caffeinated beverages a day ( coffee , soda, or energy drink). Figure 16 shows the...stress on cognitive perofrmance and mood during U.S. Navy SEAL training. Sea-Air-Land. Psychopharmacology, 164(3), 250–61. Lumley, M., Roehrs, T...T. D., French, J., & Mitcha, J. L. (1997). A study of USAF air traffic controller shiftwork: sleep, fatigue, activity, and mood analyses. Aviation

  14. Evaluating the improvements of the BOLAM meteorological model operational at ISPRA: A case study approach - preliminary results

    Science.gov (United States)

    Mariani, S.; Casaioli, M.; Lastoria, B.; Accadia, C.; Flavoni, S.

    2009-04-01

    Fritsch. A fully updated serial version of the BOLAM code has been recently acquired. Code improvements include a more precise advection scheme (Weighted Average Flux); explicit advection of five hydrometeors, and state-of-the-art parameterization schemes for radiation, convection, boundary layer turbulence and soil processes (also with possible choice among different available schemes). The operational implementation of the new code into the SIMM model chain, which requires the development of a parallel version, will be achieved during 2009. In view of this goal, the comparative verification of the different model versions' skill represents a fundamental task. On this purpose, it has been decided to evaluate the performance improvement of the new BOLAM code (in the available serial version, hereinafter BOLAM 2007) with respect to the version with the Kain-Fritsch scheme (hereinafter KF version) and to the older one employing the Kuo scheme (hereinafter Kuo version). In the present work, verification of precipitation forecasts from the three BOLAM versions is carried on in a case study approach. The intense rainfall episode occurred on 10th - 17th December 2008 over Italy has been considered. This event produced indeed severe damages in Rome and its surrounding areas. Objective and subjective verification methods have been employed in order to evaluate model performance against an observational dataset including rain gauge observations and satellite imagery. Subjective comparison of observed and forecast precipitation fields is suitable to give an overall description of the forecast quality. Spatial errors (e.g., shifting and pattern errors) and rainfall volume error can be assessed quantitatively by means of object-oriented methods. By comparing satellite images with model forecast fields, it is possible to investigate the differences between the evolution of the observed weather system and the predicted ones, and its sensitivity to the improvements in the model code

  15. Modeling and Analyzing IMA Architectures with AADL, From Modeling to Safety Evaluation and Code Generation: A Case-Study

    OpenAIRE

    Hugues, Jérôme; Delange, Julien

    2015-01-01

    Safety-Critical Systems for the aerospace domain are becoming extremely software-reliant, with tight coupling with hardware and network elements. At the same time, these have to demonstrate conformance with stringent standards so as to ensure a sufficient level of safety. In this presentation, we report on recent advances in the SAE Architecture Analysis and Design Language -- AADL -- standard and supporting tools for the modeling of avionics system and software. SAE AS2-C committee pushed fo...

  16. Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors.

    Science.gov (United States)

    Lawson, Marie; Rodrigo, Jordi; Baratte, Blandine; Robert, Thomas; Delehouzé, Claire; Lozach, Olivier; Ruchaud, Sandrine; Bach, Stéphane; Brion, Jean-Daniel; Alami, Mouad; Hamze, Abdallah

    2016-11-10

    We report here the synthesis, the biological evaluation and the molecular modeling studies of new imidazo[1,2-a]pyridines derivatives designed as potent kinase inhibitors. This collection was obtained from 2-aminopyridines and 2-bromoacetophenone which afforded final compound in only one step. The bioactivity of this family of new compounds was tested using protein kinase and ATP competition assays. The structure-activity relationship (SAR) revealed that six compounds inhibit DYRK1A and CLK1 at a micromolar range. Docking studies provided possible explanations that correlate with the SAR data. The most active compound 4c inhibits CLK1 (IC50 of 0.7 μM) and DYRK1A (IC50 of 2.6 μM).

  17. Evaluation of the interaction of coumarins with biomembrane models studied by differential scanning calorimetry and Langmuir-Blodgett techniques.

    Science.gov (United States)

    Sarpietro, Maria Grazia; Giuffrida, Maria Chiara; Ottimo, Sara; Micieli, Dorotea; Castelli, Francesco

    2011-04-25

    Three coumarins, scopoletin (1), esculetin (2), and esculin (3), were investigated by differential scanning calorimetry and Langmuir-Blodgett techniques to gain information about the interaction of these compounds with cellular membranes. Phospholipids assembled as multilamellar vesicles or monolayers (at the air-water interface) were used as biomembrane models. Differential scanning calorimetry was employed to study the interaction of these coumarins with multilamellar vesicles and to evaluate their absorption by multilamellar vesicles. These experiments indicated that 1-3 interact in this manner to different extents. The Langmuir-Blodgett technique was used to study the effect of these coumarins on the organization of phospholipids assembled as a monolayer. The data obtained were in agreement with those obtained in the calorimetric experiments.

  18. Molecular Dynamics Simulation Study of Parallel Telomeric DNA Quadruplexes at Different Ionic Strengths: Evaluation of Water and Ion Models.

    Science.gov (United States)

    Rebič, Matúš; Laaksonen, Aatto; Šponer, Jiří; Uličný, Jozef; Mocci, Francesca

    2016-08-04

    Most molecular dynamics (MD) simulations of DNA quadruplexes have been performed under minimal salt conditions using the Åqvist potential parameters for the cation with the TIP3P water model. Recently, this combination of parameters has been reported to be problematic for the stability of quadruplex DNA, especially caused by the ion interactions inside or near the quadruplex channel. Here, we verify how the choice of ion parameters and water model can affect the quadruplex structural stability and the interactions with the ions outside the channel. We have performed a series of MD simulations of the human full-parallel telomeric quadruplex by neutralizing its negative charge with K(+) ions. Three combinations of different cation potential parameters and water models have been used: (a) Åqvist ion parameters, TIP3P water model; (b) Joung and Cheatham ion parameters, TIP3P water model; and (c) Joung and Cheatham ion parameters, TIP4Pew water model. For the combinations (b) and (c), the effect of the ionic strength has been evaluated by adding increasing amounts of KCl salt (50, 100, and 200 mM). Two independent simulations using the Åqvist parameters with the TIP3P model show that this combination is clearly less suited for the studied quadruplex with K(+) as counterions. In both simulations, one ion escapes from the channel, followed by significant deformation of the structure, leading to deviating conformation compared to that in the reference crystallographic data. For the other combinations of ion and water potentials, no tendency is observed for the channel ions to escape from the quadruplex channel. In addition, the internal mobility of the three loops, torsion angles, and counterion affinity have been investigated at varied salt concentrations. In summary, the selection of ion and water models is crucial as it can affect both the structure and dynamics as well as the interactions of the quadruplex with its counterions. The results obtained with the TIP4Pew

  19. Evaluation of suspended load transport rate using transport formulas and artificial neural network models (Case study: Chelchay Catchment)

    Institute of Scientific and Technical Information of China (English)

    HADDADCHI Arman; MOVAHEDI Neshat; VAHIDI Elham; OMID Mohammad Hossein; DEHGHANI Amir Ahmad

    2013-01-01

    Accurate estimation of sediment load or transport rate is very important to a wide range of water resources projects.This study was undertaken to determine the most appropriate model to predict suspended load in the Chelchay Watershed,northeast of Iran.In total,59 data series were collected from four gravel bed-rivers and a sand bed river and two depth integrating suspended load samplers to evaluate nine suspended load formulas and feed forward backpropagation Artificial Neural Network (ANN) structures.Although the Chang formula with higher correlation coefficient (r =0.69) and lower Root Mean Square Error (RMSE =0.013) is the best suspended load predictor among the nine studied formulas,the ANN models significantly outperform traditional suspended load formulas and show their superior performance for all statistical parameters.Among different ANN structures two models including 4 inputs,4 hidden and one output neurons,and 4 inputs,4 and one hidden and one output neurons provide the best simulation with the RMSE values of 0.0009 and 0.001,respectively.

  20. Seeking for Non-Zinc-Binding MMP-2 Inhibitors: Synthesis, Biological Evaluation and Molecular Modelling Studies

    Science.gov (United States)

    Ammazzalorso, Alessandra; De Filippis, Barbara; Campestre, Cristina; Laghezza, Antonio; Marrone, Alessandro; Amoroso, Rosa; Tortorella, Paolo; Agamennone, Mariangela

    2016-01-01

    Matrix metalloproteinases (MMPs) are an important family of zinc-containing enzymes with a central role in many physiological and pathological processes. Although several MMP inhibitors have been synthesized over the years, none reached the market because of off-target effects, due to the presence of a zinc binding group in the inhibitor structure. To overcome this problem non-zinc-binding inhibitors (NZIs) have been recently designed. In a previous article, a virtual screening campaign identified some hydroxynaphtyridine and hydroxyquinoline as MMP-2 non-zinc-binding inhibitors. In the present work, simplified analogues of previously-identified hits have been synthesized and tested in enzyme inhibition assays. Docking and molecular dynamics studies were carried out to rationalize the activity data. PMID:27782083

  1. Seeking for Non-Zinc-Binding MMP-2 Inhibitors: Synthesis, Biological Evaluation and Molecular Modelling Studies

    Directory of Open Access Journals (Sweden)

    Alessandra Ammazzalorso

    2016-10-01

    Full Text Available Matrix metalloproteinases (MMPs are an important family of zinc-containing enzymes with a central role in many physiological and pathological processes. Although several MMP inhibitors have been synthesized over the years, none reached the market because of off-target effects, due to the presence of a zinc binding group in the inhibitor structure. To overcome this problem non-zinc-binding inhibitors (NZIs have been recently designed. In a previous article, a virtual screening campaign identified some hydroxynaphtyridine and hydroxyquinoline as MMP-2 non-zinc-binding inhibitors. In the present work, simplified analogues of previously-identified hits have been synthesized and tested in enzyme inhibition assays. Docking and molecular dynamics studies were carried out to rationalize the activity data.

  2. Evaluation of articular disc loading in the temporomandibular joints after prosthetic and pharmacological treatment in model studies.

    Science.gov (United States)

    Pihut, Małgorzata E; Margielewicz, Jerzy; Kijak, Edward; Wiśniewska, Grażyna

    2017-01-01

    Temporomandibular joint dysfunction is often related to excessive load in the stomatognathic system. The objective of the model tests, using numeric calculations, was to assess the articular disc loads in the temporomandibular joints after prosthetic and pharmacological treatment of functional disorders of the masticatory organ. The study involved 10 patients, aged 21-48 years, of both sexes, randomly selected from a group of 120 patients treated with relaxation occlusal splints (60 patients, group I) and intramuscular injection of botulinum toxin type A (60 patients, group II), suffering from temporomandibular joint dysfunction with the dominant muscle component. In all subjects, a specialized functional examination was carried out. Treatment groups: occlusal splint therapy (group I) and intramuscular injection of botulinum toxin type A (group II). An assessment of the loads of 4 disc zones of the temporomandibular joints was carried out based on the results of clinical studies (phase I of the study), and numeric model tests (phase II). In the representatives of the study groups (5 patients in each group), measurements of occlusal forces and an evaluation of tension of the masseter and temporalis muscle were performed. The results of the average load values for all evaluated zones of the right and left articular disc differ in a statistically significant way in favor of group II, with the exception of the external mid part of the discs. In the case of the anterior of the right disc, the load was lower in patients belonging to group I than in those obtained in group II. Botulinum toxin type A significantly reduces the loads within the temporomandibular joints, generated by masseter muscle hypertonia.

  3. Urban pluvial flood prediction: a case study evaluating radar rainfall nowcasts and numerical weather prediction models as model inputs.

    Science.gov (United States)

    Thorndahl, Søren; Nielsen, Jesper Ellerbæk; Jensen, David Getreuer

    2016-12-01

    Flooding produced by high-intensive local rainfall and drainage system capacity exceedance can have severe impacts in cities. In order to prepare cities for these types of flood events - especially in the future climate - it is valuable to be able to simulate these events numerically, both historically and in real-time. There is a rather untested potential in real-time prediction of urban floods. In this paper, radar data observations with different spatial and temporal resolution, radar nowcasts of 0-2 h leadtime, and numerical weather models with leadtimes up to 24 h are used as inputs to an integrated flood and drainage systems model in order to investigate the relative difference between different inputs in predicting future floods. The system is tested on the small town of Lystrup in Denmark, which was flooded in 2012 and 2014. Results show it is possible to generate detailed flood maps in real-time with high resolution radar rainfall data, but rather limited forecast performance in predicting floods with leadtimes more than half an hour.

  4. Development of a convenient ex vivo model for the study of the transcorneal permeation of drugs: histological and permeability evaluation.

    Science.gov (United States)

    Pescina, Silvia; Govoni, Paolo; Potenza, Arianna; Padula, Cristina; Santi, Patrizia; Nicoli, Sara

    2015-01-01

    In this paper, an ex vivo model for the study of the transcorneal permeation of drugs, based on porcine tissues, was evaluated. The setup is characterized by ease of realization, absence of O₂ and CO₂ bubbling and low cost; additionally, the large availability of porcine tissue permits a high throughput. Histological images showed the comparability between porcine and human corneas and confirmed the effectiveness of the isolation procedure. A new de-epithelization procedure based on a thermal approach was also set up to simulate cornea permeability in pathological conditions. The procedure did not affect the integrity of the underlying layers and allowed the characterization of the barrier properties of epithelium and stroma. Six compounds with different physicochemical properties were tested: fluorescein, atenolol, propranolol, diclofenac, ganciclovir and lidocaine. The model highlighted the barrier function played by epithelium toward the diffusion of hydrophilic compounds and the permselectivity with regard to more lipophilic molecules. In particular, positively charged compounds showed a significantly higher transcorneal permeability than negatively charged compounds. The comparability of results with literature data supports the goodness and the robustness of the model, especially taking into account the behavior of fluorescein, which is generally considered a marker of tissue integrity.

  5. An evaluation of a model for the systematic documentation of hospital based health promotion activities: results from a multicentre study

    DEFF Research Database (Denmark)

    Tønnesen, Hanne; Christensen, Mette E; Groene, Oliver;

    2007-01-01

    The first step of handling health promotion (HP) in Diagnosis Related Groups (DRGs) is a systematic documentation and registration of the activities in the medical records. So far the possibility and tradition for systematic registration of clinical HP activities in the medical records and in pat......The first step of handling health promotion (HP) in Diagnosis Related Groups (DRGs) is a systematic documentation and registration of the activities in the medical records. So far the possibility and tradition for systematic registration of clinical HP activities in the medical records...... of two parts; first part includes motivational counselling (7 codes) and the second part comprehends intervention, rehabilitation and after treatment (8 codes).The objective was to evaluate in an international study the usefulness, applicability and sufficiency of a simple model for the systematic...

  6. A probability model for evaluating the bias and precision of influenza vaccine effectiveness estimates from case-control studies.

    Science.gov (United States)

    Haber, M; An, Q; Foppa, I M; Shay, D K; Ferdinands, J M; Orenstein, W A

    2015-05-01

    As influenza vaccination is now widely recommended, randomized clinical trials are no longer ethical in many populations. Therefore, observational studies on patients seeking medical care for acute respiratory illnesses (ARIs) are a popular option for estimating influenza vaccine effectiveness (VE). We developed a probability model for evaluating and comparing bias and precision of estimates of VE against symptomatic influenza from two commonly used case-control study designs: the test-negative design and the traditional case-control design. We show that when vaccination does not affect the probability of developing non-influenza ARI then VE estimates from test-negative design studies are unbiased even if vaccinees and non-vaccinees have different probabilities of seeking medical care against ARI, as long as the ratio of these probabilities is the same for illnesses resulting from influenza and non-influenza infections. Our numerical results suggest that in general, estimates from the test-negative design have smaller bias compared to estimates from the traditional case-control design as long as the probability of non-influenza ARI is similar among vaccinated and unvaccinated individuals. We did not find consistent differences between the standard errors of the estimates from the two study designs.

  7. DUE PERMAFROST: A Circumpolar Remote Sensing Service for Permafrost - Evaluation Case Studies and Intercomparison with Regional Climate Model Simulations

    Science.gov (United States)

    Heim, B.; Bartsch, A.; Elger, K. K.; Rinke, A.; Matthes, H.; Zhou, X.; Klehmet, K.; Buchhorn, M.; Soliman, A. S.; Duguay, C. R.

    2013-12-01

    stakeholders and the IPA, and the ongoing evaluation of the remote sensing derived products make the DUE Permafrost products accepted by the scientific community. The Helmholtz Climate Initiative REKLIM (Regionale KlimaAnderungen/Regional climate change) is a climate research program where regional observations and process studies are coupled with model simulations (http://www.reklim.de/en/home/). The ESA DUE Permafrost User workshops initiated the use of the DUE time series within the REKLIM framework for inter-comparison experiments in order to assist the evaluation of calculated parameter fields of models. Within the REKLIM framework we spatio-temporally compare the geophysical surface parameters simulated by regional climate models with the spatio-temporal variability of Earth Observational remote sensing products. Earth Observational remote sensing products are: DUE Permafrost, DUE GlobSnow (http://www.globsnow.info) and the MODIS albedo product (MOD 43). We show intercomparison substudies on simulated fields of surface temperature and ground frozen, non-frozen state simulated by the regional climate models HIRHAM for the circumpolar domain and COSMO-CLM for Central Siberia.

  8. Evaluation of groundwater vulnerability in El-Bahariya Oasis, Western Desert, Egypt, using modelling and GIS techniques: A case study

    Science.gov (United States)

    Masoud, M. H.; El Osta, M. M.

    2016-08-01

    The Nubian Sandstone Aquifer (NSSA) is the main groundwater resource of the El-Bahariya Oasis, which is located in the middle of the Western Desert of Egypt. This aquifer is composed mainly of continental clastic sediments of sandstone with shale and clay intercalations of saturated thickness ranging between 100 and 1500 m. Vulnerability assessment to delineate areas that are more susceptible to contamination from anthropogenic sources has become an important element for sustainable resources management and land use planning. Accordingly, this research aims to estimate the vulnerability of NSSA by applying the DRASTIC model as well as utilising sensitivity analyses to evaluate the relative importance of the model parameters for aquifer vulnerability in the study area. The main objective is to demonstrate the combined use of the DRASTIC and the GIS techniques as an effective method for groundwater pollution risk assessment, and mapping the areas that are prone to deterioration of groundwater quality and quantity. Based on DRASTIC index (DI) values, a groundwater vulnerability map was produced using the GIS. The aquifer analysis in the study area highlighted the following key points: the northeastern and western parts of the NSSA were dominated by `High' vulnerability classes while the northwestern and southeastern parts were characterised by `Medium' vulnerability classes. The elevated central part of the study area displayed `Low' aquifer vulnerability. The vulnerability map shows a relatively greater risk imposed on the northeastern part of the NSSA due to the larger pollution potential of intensive vegetable cultivation. Depth-to-water, topography and hydraulic conductivity parameters were found to be more effective in assessing aquifer vulnerability.

  9. Evaluation of groundwater vulnerability in El-Bahariya Oasis, Western Desert, Egypt, using modelling and GIS techniques: A case study

    Indian Academy of Sciences (India)

    M H Masoud; M M El Osta

    2016-08-01

    The Nubian Sandstone Aquifer (NSSA) is the main groundwater resource of the El-Bahariya Oasis, which is located in the middle of the Western Desert of Egypt. This aquifer is composed mainly of continental clastic sediments of sandstone with shale and clay intercalations of saturated thickness ranging between 100 and 1500 m. Vulnerability assessment to delineate areas that are more susceptible to contamination from anthropogenic sources has become an important element for sustainable resources management and land use planning. Accordingly, this research aims to estimate the vulnerability of NSSA by applying the DRASTIC model as well as utilising sensitivity analyses to evaluate the relative importance of the model parameters for aquifer vulnerability in the study area. The main objective is to demonstrate the combined use of the DRASTIC and the GIS techniques as an effective method for groundwater pollution risk assessment, and mapping the areas that are prone to deterioration of groundwater quality and quantity. Based on DRASTIC index (DI) values, a groundwater vulnerability map was produced usingthe GIS. The aquifer analysis in the study area highlighted the following key points: the northeastern and western parts of the NSSA were dominated by ‘High’ vulnerability classes while the northwestern and southeastern parts were characterised by ‘Medium’ vulnerability classes. The elevated central partof the study area displayed ‘Low’ aquifer vulnerability. The vulnerability map shows a relatively greater risk imposed on the northeastern part of the NSSA due to the larger pollution potential of intensive vegetable cultivation. Depth-to-water, topography and hydraulic conductivity parameters were found to be more effective in assessing aquifer vulnerability.

  10. Application of Water Evaluation and Planning Model for Integrated Water Resources Management: Case Study of Langat River Basin, Malaysia

    Science.gov (United States)

    Leong, W. K.; Lai, S. H.

    2017-06-01

    Due to the effects of climate change and the increasing demand on water, sustainable development in term of water resources management has become a major challenge. In this context, the application of simulation models is useful to duel with the uncertainty and complexity of water system by providing stakeholders with the best solution. This paper outlines an integrated management planning network is developed based on Water Evaluation and Planning (WEAP) to evaluate current and future water management system of Langat River Basin, Malaysia under various scenarios. The WEAP model is known as an integrated decision support system investigate major stresses on demand and supply in terms of water availability in catchment scale. In fact, WEAP is applicable to simulate complex systems including various sectors within a single catchment or transboundary river system. To construct the model, by taking account of the Langat catchment and the corresponding demand points, we defined the hydrological model into 10 sub-hydrological catchments and 17 demand points included the export of treated water to the major cities outside the catchment. The model is calibrated and verified by several quantitative statistics (coefficient of determination, R2; Nash-Sutcliffe efficiency, NSE and Percent bias, PBIAS). The trend of supply and demand in the catchment is evaluated under three scenarios to 2050, 1: Population growth rate, 2: Demand side management (DSM) and 3: Combination of DSM and reduce non-revenue water (NRW). Results show that by reducing NRW and proper DSM, unmet demand able to reduce significantly.

  11. Social media and internet driven study recruitment: evaluating a new model for promoting collaborator engagement and participation.

    Science.gov (United States)

    Khatri, Chetan; Chapman, Stephen J; Glasbey, James; Kelly, Michael; Nepogodiev, Dmitri; Bhangu, Aneel; Fitzgerald, J Edward

    2015-01-01

    A substantial challenge facing multicentre audit and research projects is timely recruitment of collaborators and their study centres. Cost-effective strategies are required and fee-free social media has previously been identified as a potential conduit. We investigated and evaluated the effectiveness of a novel multi-format social media and Internet strategy for targeted recruitment to a national multicentre cohort study. Interventions involved a new Twitter account, including weekly live question-and-answer sessions, a new Facebook group page, online YouTube presentations and an information page on a national association website. Link tracking analysis was undertaken using Google Analytics, which was then related to subsequent registration. Social influence was calculated using the proprietary Klout score. Internet traffic analysis identified a total of 1562 unique registration site views, of which 285 originated from social media (18.2%). Some 528 unique registrations were received, with 96 via social media platforms (18.2%). Traffic source analysis identified a separate national association webpage as resulting in the majority of registration page views (15.8%), followed by Facebook (11.9%), Twitter (4.8%) and YouTube (1.5%). A combination of publicity through Facebook, Twitter and the dedicated national association webpage contributed to the greatest rise in registration traffic and accounted for 312 (48%) of the total registrations within a 2-week period. A Twitter 'social influence' (Klout) score of 42/100 was obtained during this period. Targeted social media substantially aided study dissemination and collaborator recruitment. It acted as an adjunct to traditional methods, accounting for 18.2% of collaborator registration in a short time period with no associated financial costs. We provide a practical model for designing future recruitment campaigns, and recommend Facebook, Twitter and targeted websites as the most effective adjuncts for maximising cost

  12. Social media and internet driven study recruitment: evaluating a new model for promoting collaborator engagement and participation.

    Directory of Open Access Journals (Sweden)

    Chetan Khatri

    Full Text Available A substantial challenge facing multicentre audit and research projects is timely recruitment of collaborators and their study centres. Cost-effective strategies are required and fee-free social media has previously been identified as a potential conduit. We investigated and evaluated the effectiveness of a novel multi-format social media and Internet strategy for targeted recruitment to a national multicentre cohort study.Interventions involved a new Twitter account, including weekly live question-and-answer sessions, a new Facebook group page, online YouTube presentations and an information page on a national association website. Link tracking analysis was undertaken using Google Analytics, which was then related to subsequent registration. Social influence was calculated using the proprietary Klout score.Internet traffic analysis identified a total of 1562 unique registration site views, of which 285 originated from social media (18.2%. Some 528 unique registrations were received, with 96 via social media platforms (18.2%. Traffic source analysis identified a separate national association webpage as resulting in the majority of registration page views (15.8%, followed by Facebook (11.9%, Twitter (4.8% and YouTube (1.5%. A combination of publicity through Facebook, Twitter and the dedicated national association webpage contributed to the greatest rise in registration traffic and accounted for 312 (48% of the total registrations within a 2-week period. A Twitter 'social influence' (Klout score of 42/100 was obtained during this period.Targeted social media substantially aided study dissemination and collaborator recruitment. It acted as an adjunct to traditional methods, accounting for 18.2% of collaborator registration in a short time period with no associated financial costs. We provide a practical model for designing future recruitment campaigns, and recommend Facebook, Twitter and targeted websites as the most effective adjuncts for

  13. Evaluation and clinical significance of the stomach age model for evaluating aging of the stomach-a multicenter study in China

    Science.gov (United States)

    2014-01-01

    Background A higher prevalence of chronic atrophic gastritis (CAG) occurs in younger adults in Asia. We used Stomach Age to examine the different mechanisms of CAG between younger adults and elderly individuals, and established a simple model of cancer risk that can be applied to CAG surveillance. Methods Stomach Age was determined by FISH examination of telomere length in stomach biopsies. Δψm was also determined by flow cytometry. Sixty volunteers were used to confirm the linear relationship between telomere length and age while 120 subjects were used to build a mathematical model by a multivariate analysis. Overall, 146 subjects were used to evaluate the validity of the model, and 1,007 subjects were used to evaluate the relationship between prognosis and Δage (calculated from the mathematical model). ROC curves were used to evaluate the relationship between prognosis and Δage and to determine the cut-off point for Δage. Results We established that a tight linear relationship between the telomere length and the age. The telomere length was obvious different between patients with and without CAG even in the same age. Δψm decreased in individuals whose Stomach Age was greater than real age, especially in younger adults. A mathematical model of Stomach Age (real age + Δage) was successfully constructed which was easy to apply in clinical work. A higher Δage was correlated with a worse outcome. The criterion of Δage >3.11 should be considered as the cut-off to select the subgroup of patients who require endoscopic surveillance. Conclusion Variation in Stomach Age between individuals of the same biological age was confirmed. Attention should be paid to those with a greater Stomach Age, especially in younger adults. The Δage in the Simple Model can be used as a criterion to select CAG patients for gastric cancer surveillance. PMID:25057261

  14. Photovoltaic evaluation study

    Science.gov (United States)

    Johnson, G.; Heikkilae, M.; Melasuo, T.; Spanner, S.

    Realizing the value and potential of PV-power as well as the growing need for increased cooperation and sharing of knowledge in the field of photovoltaics, FINNIDA and UNICEF decided to undertake a study of selected PV-projects. There were two main objectives for the study: To gather, compile, evaluate and share information on the photovoltaic technology appropriate to developing countries, and to promote the interest and competence of Finnish research institutes, consultants and manufacturers in photovoltaic development. For this purpose a joint evaluation of significant, primarily UN-supported projects providing for the basic needs of rural communities was undertaken. The Gambia and Kenya offered a variety of such projects, and were chosen as target countries for the study. The projects were chosen to be both comparable and complimentary. In the Gambia, the main subject was a partially integrated health and telecommunications project, but a long-operating drinking water pumping system was also studied. In Kenya, a health project in the Turkana area was examined, and also a large scale water pumping installation for fish farming. Field visits were made in order to verify and supplement the data gathered through document research and earlier investigations. Individual data gathering sheets for the project form the core of this study and are intended to give the necessary information in an organized and accessible format. The findings could practically be condensed into one sentence: PV-systems work very well, if properly designed and installed, but the resources and requirements of the recipients must be considered to a higher degree.

  15. Biomechanical evaluation of predictive parameters of progression in adolescent isthmic spondylolisthesis: a computer modeling and simulation study

    Directory of Open Access Journals (Sweden)

    Sevrain Amandine

    2012-01-01

    Full Text Available Abstract Background Pelvic incidence, sacral slope and slip percentage have been shown to be important predicting factors for assessing the risk of progression of low- and high-grade spondylolisthesis. Biomechanical factors, which affect the stress distribution and the mechanisms involved in the vertebral slippage, may also influence the risk of progression, but they are still not well known. The objective was to biomechanically evaluate how geometric sacral parameters influence shear and normal stress at the lumbosacral junction in spondylolisthesis. Methods A finite element model of a low-grade L5-S1 spondylolisthesis was constructed, including the morphology of the spine, pelvis and rib cage based on measurements from biplanar radiographs of a patient. Variations provided on this model aimed to study the effects on low grade spondylolisthesis as well as reproduce high grade spondylolisthesis. Normal and shear stresses at the lumbosacral junction were analyzed under various pelvic incidences, sacral slopes and slip percentages. Their influence on progression risk was statistically analyzed using a one-way analysis of variance. Results Stresses were mainly concentrated on the growth plate of S1, on the intervertebral disc of L5-S1, and ahead the sacral dome for low grade spondylolisthesis. For high grade spondylolisthesis, more important compression and shear stresses were seen in the anterior part of the growth plate and disc as compared to the lateral and posterior areas. Stress magnitudes over this area increased with slip percentage, sacral slope and pelvic incidence. Strong correlations were found between pelvic incidence and the resulting compression and shear stresses in the growth plate and intervertebral disc at the L5-S1 junction. Conclusions Progression of the slippage is mostly affected by a movement and an increase of stresses at the lumbosacral junction in accordance with spino-pelvic parameters. The statistical results provide

  16. An economic evaluation of salt reduction policies to reduce coronary heart disease in England: a policy modeling study.

    Science.gov (United States)

    Collins, Marissa; Mason, Helen; O'Flaherty, Martin; Guzman-Castillo, Maria; Critchley, Julia; Capewell, Simon

    2014-07-01

    Dietary salt intake has been causally linked to high blood pressure and increased risk of cardiovascular events. Cardiovascular disease causes approximately 35% of total UK deaths, at an estimated annual cost of £30 billion. The World Health Organization and the National Institute for Health and Care Excellence have recommended a reduction in the intake of salt in people's diets. This study evaluated the cost-effectiveness of four population health policies to reduce dietary salt intake on an English population to prevent coronary heart disease (CHD). The validated IMPACT CHD model was used to quantify and compare four policies: 1) Change4Life health promotion campaign, 2) front-of-pack traffic light labeling to display salt content, 3) Food Standards Agency working with the food industry to reduce salt (voluntary), and 4) mandatory reformulation to reduce salt in processed foods. The effectiveness of these policies in reducing salt intake, and hence blood pressure, was determined by systematic literature review. The model calculated the reduction in mortality associated with each policy, quantified as life-years gained over 10 years. Policy costs were calculated using evidence from published sources. Health care costs for specific CHD patient groups were estimated. Costs were compared against a "do nothing" baseline. All policies resulted in a life-year gain over the baseline. Change4life and labeling each gained approximately 1960 life-years, voluntary reformulation 14,560 life-years, and mandatory reformulation 19,320 life-years. Each policy appeared cost saving, with mandatory reformulation offering the largest cost saving, more than £660 million. All policies to reduce dietary salt intake could gain life-years and reduce health care expenditure on coronary heart disease. Copyright © 2014 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  17. A long-term evaluation of treated Class II division 2 malocclusions: a retrospective study model analysis.

    Science.gov (United States)

    Canut, J A; Arias, S

    1999-08-01

    Pre-treatment, end of treatment, and post-retention study models of 30 subjects with a Class II division 2 malocclusion were assessed, after a period of at least 3 years, in order to evaluate the long-term changes in occlusion, alignment, and arch dimensions. Molar relationship correction was found to be stable after retention. There were no variables which could be used to establish a prognosis of vertical stability. Over-correction of overbite was seen to relapse. Ten per cent of the cases showed unacceptable anterior maxillary irregularities after retention. Mandibular arch width and length usually showed a decrease after retention. An increase in lower intercanine width and arch length achieved by orthodontic treatment always relapsed. This relapse was associated with post-retention mandibular irregularity and crowding. Nine cases (30 per cent) showed an unacceptable degree of mandibular irregularity after retention. Pre-treatment crowding in the mandible showed a relationship with post-retention lower irregularity and crowding. There was a correlation between the number of years which had elapsed after retention, overbite relapse and post-retention mandibular irregularity.

  18. A multi-model multi-objective study to evaluate the role of metric choice on sensitivity assessment

    Science.gov (United States)

    Haghnegahdar, Amin; Razavi, Saman; Wheater, Howard; Gupta, Hoshin

    2016-04-01

    Sensitivity analysis (SA) is an essential tool for providing insight into model behavior, calibration, and uncertainty assessment. It is often overlooked that the metric choice can significantly change the assessment of model sensitivity. In order to identify important hydrological processes across various case studies, we conducted a multi-model multi-criteria sensitivity analysis using a novel and efficient technique, Variogram Analysis of Response Surfaces (VARS). The analysis was conducted using three physically-based hydrological models, applied at various scales ranging from small (hillslope) to large (watershed) scale. In each case, the sensitivity of simulated streamflow to model processes (represented through parameters) were measured using different metrics selected based on various hydrograph characteristics including high flows, low flows, and volume. It is demonstrated that metric choice has a significant influence on SA results and must be aligned with study objectives. Guidelines for identifying important model parameters from a multi-objective SA perspective is discussed as part of this study.

  19. Evaluation of model fit in nonlinear multilevel structural equation modeling

    Directory of Open Access Journals (Sweden)

    Karin eSchermelleh-Engel

    2014-03-01

    Full Text Available Evaluating model fit in nonlinear multilevel structural equation models (MSEM presents a challenge as no adequate test statistic is available. Nevertheless, using a product indicator approach a likelihood ratio test for linear models is provided which may also be useful for nonlinear MSEM. The main problem with nonlinear models is that product variables are nonnormally distributed. Although robust test statistics have been developed for linear SEM to ensure valid results under the condition of nonnormality, they were not yet investigated for nonlinear MSEM. In a Monte Carlo study, the performance of the robust likelihood ratio test was investigated for models with single-level latent interaction effects using the unconstrained product indicator approach. As overall model fit evaluation has a potential limitation in detecting the lack of fit at a single level even for linear models, level-specific model fit evaluation was also investigated using partially saturated models. Four population models were considered: a model with interaction effects at both levels, an interaction effect at the within-group level, an interaction effect at the between-group level, and a model with no interaction effects at both levels. For these models the number of groups, predictor correlation, and model misspecification was varied. The results indicate that the robust test statistic performed sufficiently well. Advantages of level-specific model fit evaluation for the detection of model misfit are demonstrated.

  20. Evaluation of model fit in nonlinear multilevel structural equation modeling.

    Science.gov (United States)

    Schermelleh-Engel, Karin; Kerwer, Martin; Klein, Andreas G

    2014-01-01

    Evaluating model fit in nonlinear multilevel structural equation models (MSEM) presents a challenge as no adequate test statistic is available. Nevertheless, using a product indicator approach a likelihood ratio test for linear models is provided which may also be useful for nonlinear MSEM. The main problem with nonlinear models is that product variables are non-normally distributed. Although robust test statistics have been developed for linear SEM to ensure valid results under the condition of non-normality, they have not yet been investigated for nonlinear MSEM. In a Monte Carlo study, the performance of the robust likelihood ratio test was investigated for models with single-level latent interaction effects using the unconstrained product indicator approach. As overall model fit evaluation has a potential limitation in detecting the lack of fit at a single level even for linear models, level-specific model fit evaluation was also investigated using partially saturated models. Four population models were considered: a model with interaction effects at both levels, an interaction effect at the within-group level, an interaction effect at the between-group level, and a model with no interaction effects at both levels. For these models the number of groups, predictor correlation, and model misspecification was varied. The results indicate that the robust test statistic performed sufficiently well. Advantages of level-specific model fit evaluation for the detection of model misfit are demonstrated.

  1. [Evaluation model for municipal health planning management].

    Science.gov (United States)

    Berretta, Isabel Quint; Lacerda, Josimari Telino de; Calvo, Maria Cristina Marino

    2011-11-01

    This article presents an evaluation model for municipal health planning management. The basis was a methodological study using the health planning theoretical framework to construct the evaluation matrix, in addition to an understanding of the organization and functioning designed by the Planning System of the Unified National Health System (PlanejaSUS) and definition of responsibilities for the municipal level under the Health Management Pact. The indicators and measures were validated using the consensus technique with specialists in planning and evaluation. The applicability was tested in 271 municipalities (counties) in the State of Santa Catarina, Brazil, based on population size. The proposed model features two evaluative dimensions which reflect the municipal health administrator's commitment to planning: the guarantee of resources and the internal and external relations needed for developing the activities. The data were analyzed using indicators, sub-dimensions, and dimensions. The study concludes that the model is feasible and appropriate for evaluating municipal performance in health planning management.

  2. Modeling for Green Supply Chain Evaluation

    Directory of Open Access Journals (Sweden)

    Elham Falatoonitoosi

    2013-01-01

    Full Text Available Green supply chain management (GSCM has become a practical approach to develop environmental performance. Under strict regulations and stakeholder pressures, enterprises need to enhance and improve GSCM practices, which are influenced by both traditional and green factors. This study developed a causal evaluation model to guide selection of qualified suppliers by prioritizing various criteria and mapping causal relationships to find effective criteria to improve green supply chain. The aim of the case study was to model and examine the influential and important main GSCM practices, namely, green logistics, organizational performance, green organizational activities, environmental protection, and green supplier evaluation. In the case study, decision-making trial and evaluation laboratory technique is applied to test the developed model. The result of the case study shows only “green supplier evaluation” and “green organizational activities” criteria of the model are in the cause group and the other criteria are in the effect group.

  3. Histological evaluation of the biocompatibility of polyurea crosslinked silica aerogel implants in a rat model: a pilot study.

    Directory of Open Access Journals (Sweden)

    Firouzeh Sabri

    Full Text Available BACKGROUND: Aerogels are a versatile group of nanostructured/nanoporous materials with physical and chemical properties that can be adjusted to suit the application of interest. In terms of biomedical applications, aerogels are particularly suitable for implants such as membranes, tissue growth scaffolds, and nerve regeneration and guidance inserts. The mesoporous nature of aerogels can also be used for diffusion based release of drugs that are loaded during the drying stage of the material. From the variety of aerogels polyurea crosslinked silica aerogels have the most potential for future biomedical applications and are explored here. METHODOLOGY: This study assessed the short and long term biocompatibility of polyurea crosslinked silica aerogel implants in a Sprague-Dawley rat model. Implants were inserted at two different locations a subcutaneously (SC, at the dorsum and b intramuscularly (IM, between the gluteus maximus and biceps femoris of the left hind extremity. Nearby muscle and other internal organs were evaluated histologically for inflammation, tissue damage, fibrosis and movement (travel of implant. CONCLUSION/SIGNIFICANCE: In general polyurea crosslinked silica aerogel (PCSA was well tolerated as a subcutaneous and an intramuscular implant in the Sprague-Dawley rat with a maximum incubation time of twenty months. In some cases a thin fibrous capsule surrounded the aerogel implant and was interpreted as a normal response to foreign material. No noticeable toxicity was found in the tissues surrounding the implants nor in distant organs. Comparison was made with control rats without any implants inserted, and animals with suture material present. No obvious or noticeable changes were sustained by the implants at either location. Careful necropsy and tissue histology showed age-related changes only. An effective sterilization technique for PCSA implants as well as staining and sectioning protocol has been established. These studies

  4. Program evaluation and case study

    OpenAIRE

    Kushner, S

    2009-01-01

    This entry looks at the convergence of case study methodology and program evaluation. An early insight of some educational evaluation theorists was of the convergence of case study and program evaluation – the fusion of method with purpose. Program evaluation and case study came to be mutually-bracketed. In the educational evaluation field 'Responsive', 'Democratic', 'Illuminative' methodologies were developed in parallel with case study methods - the same authors contributing freely to both ...

  5. Modeling and Evaluating Pilot Performance in NextGen: Review of and Recommendations Regarding Pilot Modeling Efforts, Architectures, and Validation Studies

    Science.gov (United States)

    Wickens, Christopher; Sebok, Angelia; Keller, John; Peters, Steve; Small, Ronald; Hutchins, Shaun; Algarin, Liana; Gore, Brian Francis; Hooey, Becky Lee; Foyle, David C.

    2013-01-01

    NextGen operations are associated with a variety of changes to the national airspace system (NAS) including changes to the allocation of roles and responsibilities among operators and automation, the use of new technologies and automation, additional information presented on the flight deck, and the entire concept of operations (ConOps). In the transition to NextGen airspace, aviation and air operations designers need to consider the implications of design or system changes on human performance and the potential for error. To ensure continued safety of the NAS, it will be necessary for researchers to evaluate design concepts and potential NextGen scenarios well before implementation. One approach for such evaluations is through human performance modeling. Human performance models (HPMs) provide effective tools for predicting and evaluating operator performance in systems. HPMs offer significant advantages over empirical, human-in-the-loop testing in that (1) they allow detailed analyses of systems that have not yet been built, (2) they offer great flexibility for extensive data collection, (3) they do not require experimental participants, and thus can offer cost and time savings. HPMs differ in their ability to predict performance and safety with NextGen procedures, equipment and ConOps. Models also vary in terms of how they approach human performance (e.g., some focus on cognitive processing, others focus on discrete tasks performed by a human, while others consider perceptual processes), and in terms of their associated validation efforts. The objectives of this research effort were to support the Federal Aviation Administration (FAA) in identifying HPMs that are appropriate for predicting pilot performance in NextGen operations, to provide guidance on how to evaluate the quality of different models, and to identify gaps in pilot performance modeling research, that could guide future research opportunities. This research effort is intended to help the FAA

  6. Evaluation of black carbon emission inventories using a Lagrangian dispersion model – a case study over Southern India

    Directory of Open Access Journals (Sweden)

    H. S. Gadhavi

    2014-10-01

    Full Text Available We evaluated three emission inventories of black carbon (BC using Lagrangian particle dispersion model simulations and BC observations from a rural site in Southern India (Gadanki; 13.48° N, 79.18° E from 2008 to 2012. We found that 93 to 95% of the BC load at the observation site originated from emissions in India and the rest from the neighbouring countries and shipping. A substantial fraction (33 to 43% of the BC was transported from Northern India. Wet deposition is found to play a minor role in reducing BC mass at the site because of its proximity to BC sources during rainy season and relatively short rainy season over western and northern parts of India. Seasonally, the highest BC concentration (approx. 3.3 μg m−3 is observed during winter, followed by spring (approx. 2.8 μg m−3. While the model reproduced well the seasonal cycle, the modelled BC concentrations are significantly lower than observed values, especially in spring. The model bias is correlated to fire radiative power – a proxy of open biomass burning activity. Using potential emission sensitivity maps derived using the model, we suggest that underestimation of BC mass in the model during spring is due to the underestimation of BC fluxes over Southern India (possibly from open-biomass-burning/forest-fires. The overall performance of the model simulations using three different emission inventories (SAFAR-India, ECLIPSE and RETRO is similar, with ECLIPSE and SAFAR-India performing marginally better as both have about 30% higher emissions for India than RETRO. The ratio of observed to modelled annual mean BC concentration was estimated as 1.5 for SAFAR, 1.7 for ECLIPSE and 2.4 for RETRO.

  7. Evaluation criteria for AIS 1 neck injuries in frontal impacts--a parameter study combining field data and Madymo modeling.

    Science.gov (United States)

    Jakobsson, Lotta; Lundgren, Kristina; Norin, Hans; Svensson, Mats

    2004-12-01

    Two situations with an expected higher AIS 1 neck injury rate in frontal impact were compared to a reference situation using a Madymo human body model in three different sitting postures and four different crash pulses. The two situations were reduced occupant weight and occupant with initial forward arm resistance, respectively. Occupant neck motion phases were identified and corresponding possible evaluation criteria were evaluated within the phases. Typical neck kinematics was seen for the two different situations. Occupants of lower weight had a more extended neck in the initial protraction phase and also a generally more pronounced upper neck link angle. Occupants with initial arm resistance had generally greater lower neck link angle at the time when the upper neck link angle was straight. No evaluation criteria reflected the anticipated AIS 1 neck injury rate consistently. In the initial protraction phase, NICmin correlated to expected injury outcome in almost half of the cases. In the protraction-flexion shift phase, Nkm, Nij, upper neck shear force and neck tension force reflected anticipated severity outcome to some extent. In the flexion phase, upper and lower neck extension correlated to anticipated AIS 1 neck injury rate only to a minor extent. The different sitting postures were more influential than the different crash pulses, emphasizing the importance of not only considering the spectra of impact severity but also differences in sitting postures in safety system development and evaluation.

  8. Evaluating and Refining the Conceptual Model Used in the Study of Health and Activity in Preschool Environments (SHAPES) Intervention.

    Science.gov (United States)

    Saunders, Ruth P; Pfeiffer, Karin; Brown, William H; Howie, Erin K; Dowda, Marsha; O'Neill, Jennifer R; McIver, Kerry; Pate, Russell R

    2017-01-01

    This study investigated the utility of the Study of Health and Activity in Preschool Environments (SHAPES) conceptual model, which targeted physical activity (PA) behavior in preschool children, by examining the relationship between implementation monitoring data and child PA during the school day. We monitored implementation completeness and fidelity based on multiple elements identified in the conceptual model. Comparing high-implementing, low-implementing, and control groups revealed no association between implementation and outcomes. We performed post hoc analyses, using process data, to refine our conceptual model's depiction of an effective preschool PA-promoting environment. Results suggest that a single component of the original four-component conceptual model, providing opportunities for moderate-to-vigorous physical activity through recess for 4-year-old children in preschool settings, may be a good starting place for increasing moderate-to-vigorous physical activity. Interventions that are implemented with optimal levels of completeness and fidelity are more likely to achieve behavior change if they are based on accurate conceptual models. Examining the mechanisms through which an intervention produces its effects, as articulated in the conceptual model that guides it, is particularly important for environmentally focused interventions because they are guided by emerging frameworks. The results of this study underscore the utility of using implementation monitoring data to examine the conceptual model on which the intervention is based.

  9. Nicaraguan and US nursing collaborative evaluation study: Identifying similarities and differences between US and Nicaraguan curricula and teaching modalities using the community engagement model.

    Science.gov (United States)

    Lake, Donna; Engelke, Martha K; Kosko, Debra A; Roberson, Donna W; Jaime, Joba Fany; López, Feliciana Rojas; Rivas, Fidelia Mercedes Poveda; Salazar, Yolanda Matute; Salmeron, Juana Julia

    2017-04-01

    Curricula evaluation is an essential phase of curriculum development. Study describes the implementation of a formative evaluation used by faculty members between Universidad Nacional Autonóma de Nicaragua (UNAN-Leon) Escuela de Enfermeriá, Nicaragua and East Carolina University College of Nursing (ECU CON) in North Carolina, US. Program evaluation study to conduct an assessment, comparison of a medical-surgical adult curriculum and teaching modalities. Also, explore the Community Engagement (CE) Model to build a Central American-US faculty partnership. Methodological evaluation study utilizing a newly developed International Nursing Education Curriculum Evaluation Tool related to adult medical and surgical nursing standards. Also, the CE Model was tested as a facilitation tool in building partnerships between nurse educators. Nicaragua and US nursing faculty teams constructed the curriculum evaluation by utilizing the International Nursing Education Curriculum Evaluation Tool (INECET) by reviewing 57 elements covering 6 Domains related to adult medical and surgical nursing standards. Developed, explored the utilization of the INECET based on a standard of practice framework. The Community Engagement Model, a fivephase cycle, Inform, Consult, Involve, Collaborate, and Empower was utilized to facilitate the collaborative process. Similarities between the US and Nicaraguan curricula and teaching modalities were reflective based on the 57 elements covering 6 Domain assessment tool. Case studies, lecture, and clinical hospital rotations were utilized as teaching modalities. Both schools lacked sufficient time for clinical practicum time. The differences, included UNAN-Leon had a lack of simulation skill lab, equipment, and space, whereas ECU CON had sufficient resources. The ECU school lacked applied case studies from a rural health medical-surgical adult nursing perspective and less time in rural health clinics. The UNAN-Leon nursing standards generalized based on

  10. A model compound study: the ecotoxicological evaluation of five organic contaminants employing a battery of marine bioassays.

    Science.gov (United States)

    Macken, Ailbhe; Giltrap, Michelle; Foley, Barry; McGovern, Evin; McHugh, Brendan; Davoren, Maria

    2008-06-01

    This paper describes the ecotoxicological evaluation of five organic contaminants frequently detected in marine sediments (tributyltin, triphenyltin, benzo[a]pyrene, fluoranthene, and PCB 153) using three marine species (Vibrio fischeri, Tetraselmis suecica, and Tisbe battagliai). The sensitivity of each species varied for all compounds. The triorganotins were consistently the most toxic to all species. The applicability of each test system to assess the acute toxicity of environmental contaminants and their use in Toxicity Identification Evaluation (TIE) is discussed. Suitability of the Microtox and T. battagliai tests for employment in TIE studies were further assessed through spiking experiments with tributyltin. Results demonstrated that the most effective treatment to remove organotin toxicity from the sample was the C18 resin. The results of this study have important implications for risk assessment in estuarine and coastal waters in Ireland, where, at present the monitoring of sediment and water quality is predominantly reliant on chemical analysis alone.

  11. [Follow-up studies and clinical evaluation of model cast dentures with periodontal and periodonto-gingival support].

    Science.gov (United States)

    Ebersbach, W; Lesche, M

    1977-11-01

    The authors examined 746 cast denture constructions with an average wearing time of 6 years to study the influence of cast denture constructions on caries increment. The mode of wear of the cast denture constructions had no influence on caries incidence, whereas effects exerted by the duration of wear and the presence of soft deposits could be detected. The evaluation of the functional performance of cast denture constructions showed that the clinical serviceability amounts to more than 8 years.

  12. A bivariate measurement error model for nitrogen and potassium intakes to evaluate the performance of regression calibration in the European Prospective Investigation into Cancer and Nutrition study

    NARCIS (Netherlands)

    Ferrari, P.; Roddam, A.; Fahey, M. T.; Jenab, M.; Bamia, C.; Ocke, M.; Amiano, P.; Hjartaker, A.; Biessy, C.; Rinaldi, S.; Huybrechts, I.; Tjonneland, A.; Dethlefsen, C.; Niravong, M.; Clavel-Chapelon, F.; Linseisen, J.; Boeing, H.; Oikonomou, E.; Orfanos, P.; Palli, D.; de Magistris, M. Santucci; Bueno-de-Mesquita, H. B.; Peeters, P. H. M.; Parr, C. L.; Braaten, T.; Dorronsoro, M.; Berenguer, T.; Gullberg, B.; Johansson, I.; Welch, A. A.; Riboli, E.; Bingham, S.; Slimani, N.

    2009-01-01

    Objectives: Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, the performance of 24-h dietary recall (24-HDR) measurements as reference measurements in a linear regression calibration model is evaluated critically at the individual (within-centre) and aggregate

  13. WWC Review of the Report "Longitudinal Evaluation of a Scale-up Model for Teaching Mathematics with Trajectories and Technologies." What Works Clearinghouse Single Study Review

    Science.gov (United States)

    What Works Clearinghouse, 2014

    2014-01-01

    The 2012 study, "Longitudinal Evaluation of a Scale-Up Model for Teaching Mathematics with Trajectories and Technologies," examined the effects of "Technology-enhanced, Research-based, Instruction, Assessment, and professional Development (TRIAD)," a math intervention for preschoolers that combines a curriculum, a…

  14. A bivariate measurement error model for nitrogen and potassium intakes to evaluate the performance of regression calibration in the European Prospective Investigation into Cancer and Nutrition study

    NARCIS (Netherlands)

    Ferrari, P.; Roddam, A.; Fahey, M. T.; Jenab, M.; Bamia, C.; Ocke, M.; Amiano, P.; Hjartaker, A.; Biessy, C.; Rinaldi, S.; Huybrechts, I.; Tjonneland, A.; Dethlefsen, C.; Niravong, M.; Clavel-Chapelon, F.; Linseisen, J.; Boeing, H.; Oikonomou, E.; Orfanos, P.; Palli, D.; de Magistris, M. Santucci; Bueno-de-Mesquita, H. B.; Peeters, P. H. M.; Parr, C. L.; Braaten, T.; Dorronsoro, M.; Berenguer, T.; Gullberg, B.; Johansson, I.; Welch, A. A.; Riboli, E.; Bingham, S.; Slimani, N.

    2009-01-01

    Objectives: Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, the performance of 24-h dietary recall (24-HDR) measurements as reference measurements in a linear regression calibration model is evaluated critically at the individual (within-centre) and aggregate (b

  15. Performability Modelling Tools, Evaluation Techniques and Applications

    NARCIS (Netherlands)

    Haverkort, Boudewijn R.H.M.

    1990-01-01

    This thesis deals with three aspects of quantitative evaluation of fault-tolerant and distributed computer and communication systems: performability evaluation techniques, performability modelling tools, and performability modelling applications. Performability modelling is a relatively new

  16. Evaluation of mechanical load in the musculoskeletal system : development of experimental and modeling methodologies for the study of the effect of exercise in human models

    OpenAIRE

    João, Filipa Oliveira da Silva

    2013-01-01

    Doutoramento em Motricidade Humana, na especialidade de Biomecânica A major concern of Biomechanics research is the evaluation of the mechanical load and power that the human body develops and endorses when performing high to moderate sport activities. With the purpose of increasing performance and reducing the risk of injury, substantial advances were accomplished to pursuit this goal, either on the laboratory techniques as well as modelling and simulation. Traditionally, the main focus w...

  17. A Study on Theoretical Model and Applied Evaluation of Land Use Performance of High-tech Zone in Urban Fringe: A Case Study in Haidian District, Beijing

    Institute of Scientific and Technical Information of China (English)

    Ban Maosheng; Fang Chuanglin; Liu Xiaoli

    2008-01-01

    High-tech industrial zone is an important carrier for constructing innovative cities.It also plays an important role in implementing the national independent innovative strategy.However,most of the high-tech industrial zones have many problems in their development process,such as efficiency of land use,weakness of oriented function and lack of land intensive.To solve these problems,the authors of this paper introduced the concept of land use performance and established the theoretical model to assess the land use performance of high-tech industrial zones.The model consists of the following three-dimensional parts:land use benefit,land use efficiency and innovative function.Based on this theory model,an index system which was composed of three secondary indictors,eight tertiary indictors and 37 fottrth-grade indictors was set up to evaluate the land use performance of high-teeh zone.To avoid the defects of plus model and function model,the authors brought out a three-dimensional evaluation model to examine the index of the land use performance of the high-tech industrial parks,which equals to the evaluation indicator system of land use performance of high-tech zone based on the above research.The authors examined the land use performance of five different high-tech industrial parks in Haidian District,Beijing City.The results indicated that the indicator system performs better in the aspect of evaluating land use benefit,land use efficiency and function of the high-teeh industrial zone compared with other models.

  18. Evaluation of a nurse practitioner disease management model for chronic heart failure: a multi-site implementation study.

    Science.gov (United States)

    Lowery, Julie; Hopp, Faith; Subramanian, Usha; Wiitala, Wyndy; Welsh, Deborah E; Larkin, Angela; Stemmer, Karen; Zak, Cassandra; Vaitkevicius, Peter

    2012-01-01

    While disease management appears to be effective in selected, small groups of CHF patients from randomized controlled trials, its effectiveness in a broader CHF patient population is not known. This prospective, quasi-experimental study compared patient outcomes under a nurse practitioner-led disease management model (intervention group) with outcomes under usual care (control group) in both primary and tertiary medical centers. The study included 969 veterans (458 intervention, 511 control) treated for CHF at six VA medical centers. Intervention patients had significantly fewer (pmanagement models for CHF can be translated into clinical practice, even without the benefits of a selected patient population and dedicated resources often found in RCTs. © 2011 Wiley Periodicals, Inc.

  19. Radon as a tool for characterising atmospheric stability effects on air pollution concentrations in model evaluation studies

    Science.gov (United States)

    Chambers, Scott; Williams, Alastair; Crawford, Jagoda; Griffiths, Alan

    2015-04-01

    A clearer understanding of the variability in near-surface concentrations of pollutants in urban regions is essential for improving the predictive abilities of chemical transport models as well as identifying the need for (and assessing the efficacy of) emission mitigation strategies. Pollutant concentrations in the atmospheric boundary layer (ABL) are a complex function of many factors, including: source strengths and distribution, local meteorology and air chemistry. On short (sub-diurnal) timescales, the extent of the vertical column within which emissions mix usually has the largest influence on measured concentrations, and the depth of this mixing volume is in turn closely related to wind speed and the thermal stability of the ABL. Continuous hourly observations of the ubiquitous, surface-emitted, passive tracer radon-222 provide a powerful alternative to contemporary meteorological techniques for assessing stability effects on urban pollutants, because radon's concentration is closely matched with pollution transport processes at the surface. Here we outline a technique by which single-height, near-surface (pollution monitoring to provide benchmarking tools for local- to regional- chemical transport model evaluations. Efficacy of the radon-based classification scheme is compared to that based on conventional Pasquil-Gifford "turbulence" and "radiation" schemes. Lastly, we apply the radon-based classification scheme to nocturnal mixing height estimates calculated from the diurnal radon accumulation time series, and provide insight to the range of nocturnal mixing depths expected for each of the stability classes.

  20. Evaluation of urban surface parameterizations in the WRF model using measurements during the Texas Air Quality Study 2006 field campaign

    Directory of Open Access Journals (Sweden)

    S.-H. Lee

    2010-10-01

    Full Text Available The impact of urban surface parameterizations in the WRF (Weather Research and Forecasting model on the simulation of local meteorological fields is investigated. The Noah land surface model (LSM, a modified LSM, and a single-layer urban canopy model (UCM have been compared, focusing on urban patches. The model simulations were performed for 6 days from 12 August to 17 August during the Texas Air Quality Study 2006 field campaign. Analysis was focused on the Houston-Galveston metropolitan area. The model simulated temperature, wind, and atmospheric boundary layer (ABL height were compared with observations from surface meteorological stations (Continuous Ambient Monitoring Stations, CAMS, wind profilers, the NOAA Twin Otter aircraft, and the NOAA Research Vessel Ronald H. Brown. The UCM simulation showed better results in the comparison of ABL height and surface temperature than the LSM simulations, whereas the original LSM overestimated both the surface temperature and ABL height significantly in urban areas. The modified LSM, which activates hydrological processes associated with urban vegetation mainly through transpiration, slightly reduced warm and high biases in surface temperature and ABL height. A comparison of surface energy balance fluxes in an urban area indicated the UCM reproduces a realistic partitioning of sensible heat and latent heat fluxes, consequently improving the simulation of urban boundary layer. However, the LSMs have a higher Bowen ratio than the observation due to significant suppression of latent heat flux. The comparison results suggest that the subgrid heterogeneity by urban vegetation and urban morphological characteristics should be taken into account along with the associated physical parameterizations for accurate simulation of urban boundary layer if the region of interest has a large fraction of vegetation within the urban patch. Model showed significant discrepancies in the specific meteorological

  1. Evaluation of Usability Utilizing Markov Models

    Science.gov (United States)

    Penedo, Janaina Rodrigues; Diniz, Morganna; Ferreira, Simone Bacellar Leal; Silveira, Denis S.; Capra, Eliane

    2012-01-01

    Purpose: The purpose of this paper is to analyze the usability of a remote learning system in its initial development phase, using a quantitative usability evaluation method through Markov models. Design/methodology/approach: The paper opted for an exploratory study. The data of interest of the research correspond to the possible accesses of users…

  2. Evaluation Model for Sentient Cities

    Directory of Open Access Journals (Sweden)

    Mª Florencia Fergnani Brion

    2016-11-01

    Full Text Available In this article we made a research about the Sentient Cities and produced an assessment model to analyse if a city is or could be potentially considered one. It can be used to evaluate the current situation of a city before introducing urban policies based on citizen participation in hybrid environments (physical and digital. To that effect, we've developed evaluation grids with the main elements that form a Sentient City and their measurement values. The Sentient City is a variation of the Smart City, also based on technology progress and innovation, but where the citizens are the principal agent. In this model, governments aim to have a participatory and sustainable system for achieving the Knowledge Society and Collective Intelligence development, as well as the city’s efficiency. Also, they increase communication channels between the Administration and citizens. In this new context, citizens are empowered because they have the opportunity to create a Local Identity and transform their surroundings through open and horizontal initiatives.

  3. Evaluating models of vowel perception

    Science.gov (United States)

    Molis, Michelle R.

    2005-08-01

    There is a long-standing debate concerning the efficacy of formant-based versus whole spectrum models of vowel perception. Categorization data for a set of synthetic steady-state vowels were used to evaluate both types of models. The models tested included various combinations of formant frequencies and amplitudes, principal components derived from excitation patterns, and perceptually scaled LPC cepstral coefficients. The stimuli were 54 five-formant synthesized vowels that had a common F1 frequency and varied orthogonally in F2 and F3 frequency. Twelve speakers of American English categorized the stimuli as the vowels /smcapi/, /capomega/, or /hkbkeh/. Results indicate that formant frequencies provided the best account of the data only if nonlinear terms, in the form of squares and cross products of the formant values, were also included in the analysis. The excitation pattern principal components also produced reasonably accurate fits to the data. Although a wish to use the lowest-dimensional representation would dictate that formant frequencies are the most appropriate vowel description, the relative success of richer, more flexible, and more neurophysiologically plausible whole spectrum representations suggests that they may be preferred for understanding human vowel perception.

  4. Proposal for a Conceptual Model for Evaluating Lean Product Development Performance: A Study of LPD Enablers in Manufacturing Companies

    Science.gov (United States)

    Osezua Aikhuele, Daniel; Mohd Turan, Faiz

    2016-02-01

    The instability in today's market and the emerging demands for mass customized products by customers, are driving companies to seek for cost effective and time efficient improvements in their production system and this have led to real pressure for the adaptation of new developmental architecture and operational parameters to remain competitive in the market. Among such developmental architecture adopted, is the integration of lean thinking in the product development process. However, due to lack of clear understanding of the lean performance and its measurements, many companies are unable to implement and fully integrate the lean principle into their product development process and without a proper performance measurement, the performance level of the organizational value stream will be unknown and the specific area of improvement as it relates to the LPD program cannot be tracked. Hence, it will result in poor decision making in the LPD implementation. This paper therefore seeks to present a conceptual model for evaluation of LPD performances by identifying and analysing the core existing LPD enabler (Chief Engineer, Cross-functional teams, Set-based engineering, Poka-yoke (mistakeproofing), Knowledge-based environment, Value-focused planning and development, Top management support, Technology, Supplier integration, Workforce commitment and Continuous improvement culture) for assessing the LPD performance.

  5. Case Study of the Chaq-Chaq Dam Failure: Parameter Estimation and Evaluation of Dam Breach Prediction Models

    Directory of Open Access Journals (Sweden)

    Dr. KawaZedanAbdulrahman

    2014-05-01

    Full Text Available On 4th of February, 2006 at about 10:00 pm.Chaq-Chaq dam failed due to overtopping. The fall of 131.2 mm of rain over a 24-hour period was recorded at Sulaimani metrological gage station, which is located about 7.5Kmsouth-east of the dam. As a result, the reservoir level rose, the dam has been overtopped and finally breached near the spillway at the right abutment. Fortunately no human lives loss nor important structure destruction were reporteddue to the dam failure. The aim of this paper is to estimate the flood hydrograph passing through Chaq-Chaq dam breach using measured breach geometry as input to unsteady option of HEC RAS 4.1.0 and calibrating the breach formation time to obtain the measured maximum water surface at Chaq-Chaq Bridge (1.36 km downstream of dam axis. In addition the recent breach prediction models were evaluated to check their accuracy in predicting the breach geometry, breach formation time and peak breach discharge.

  6. Evaluation Strategy Michael Porter's five forces model of the competitive environment on the dairy industry (Case Study: Amoll Haraz Dvshh dairy company)

    OpenAIRE

    Mohammad Bolorian Tehrani; Faezeh Rahmani

    2016-01-01

    State of competition in an industry depends on five basic forces. Porter's five forces model including bargaining power of customers, bargaining power of suppliers, threat of newcomers to the industry, threat of substitute products is the intensity of rivalry between competitors. Joint strength of these forces determines the ultimate benefit of potentially any industry. The purpose of this study was to evaluate the competitive environment of the dairy industry based on Michael Por...

  7. Risk Quantification and Evaluation Modelling

    Directory of Open Access Journals (Sweden)

    Manmohan Singh

    2014-07-01

    Full Text Available In this paper authors have discussed risk quantification methods and evaluation of risks and decision parameter to be used for deciding on ranking of the critical items, for prioritization of condition monitoring based risk and reliability centered maintenance (CBRRCM. As time passes any equipment or any product degrades into lower effectiveness and the rate of failure or malfunctioning increases, thereby lowering the reliability. Thus with the passage of time or a number of active tests or periods of work, the reliability of the product or the system, may fall down to a low value known as a threshold value, below which the reliability should not be allowed to dip. Hence, it is necessary to fix up the normal basis for determining the appropriate points in the product life cycle where predictive preventive maintenance may be applied in the programme so that the reliability (the probability of successful functioning can be enhanced, preferably to its original value, by reducing the failure rate and increasing the mean time between failure. It is very important for defence application where reliability is a prime work. An attempt is made to develop mathematical model for risk assessment and ranking them. Based on likeliness coefficient β1 and risk coefficient β2 ranking of the sub-systems can be modelled and used for CBRRCM.Defence Science Journal, Vol. 64, No. 4, July 2014, pp. 378-384, DOI:http://dx.doi.org/10.14429/dsj.64.6366 

  8. Study on an Air Quality Evaluation Model for Beijing City Under Haze-Fog Pollution Based on New Ambient Air Quality Standards

    Science.gov (United States)

    Li, Li; Liu, Dong-Jun

    2014-01-01

    Since 2012, China has been facing haze-fog weather conditions, and haze-fog pollution and PM2.5 have become hot topics. It is very necessary to evaluate and analyze the ecological status of the air environment of China, which is of great significance for environmental protection measures. In this study the current situation of haze-fog pollution in China was analyzed first, and the new Ambient Air Quality Standards were introduced. For the issue of air quality evaluation, a comprehensive evaluation model based on an entropy weighting method and nearest neighbor method was developed. The entropy weighting method was used to determine the weights of indicators, and the nearest neighbor method was utilized to evaluate the air quality levels. Then the comprehensive evaluation model was applied into the practical evaluation problems of air quality in Beijing to analyze the haze-fog pollution. Two simulation experiments were implemented in this study. One experiment included the indicator of PM2.5 and was carried out based on the new Ambient Air Quality Standards (GB 3095-2012); the other experiment excluded PM2.5 and was carried out based on the old Ambient Air Quality Standards (GB 3095-1996). Their results were compared, and the simulation results showed that PM2.5 was an important indicator for air quality and the evaluation results of the new Air Quality Standards were more scientific than the old ones. The haze-fog pollution situation in Beijing City was also analyzed based on these results, and the corresponding management measures were suggested. PMID:25170682

  9. Study on an air quality evaluation model for Beijing City under haze-fog pollution based on new ambient air quality standards.

    Science.gov (United States)

    Li, Li; Liu, Dong-Jun

    2014-08-28

    Since 2012, China has been facing haze-fog weather conditions, and haze-fog pollution and PM2.5 have become hot topics. It is very necessary to evaluate and analyze the ecological status of the air environment of China, which is of great significance for environmental protection measures. In this study the current situation of haze-fog pollution in China was analyzed first, and the new Ambient Air Quality Standards were introduced. For the issue of air quality evaluation, a comprehensive evaluation model based on an entropy weighting method and nearest neighbor method was developed. The entropy weighting method was used to determine the weights of indicators, and the nearest neighbor method was utilized to evaluate the air quality levels. Then the comprehensive evaluation model was applied into the practical evaluation problems of air quality in Beijing to analyze the haze-fog pollution. Two simulation experiments were implemented in this study. One experiment included the indicator of PM2.5 and was carried out based on the new Ambient Air Quality Standards (GB 3095-2012); the other experiment excluded PM2.5 and was carried out based on the old Ambient Air Quality Standards (GB 3095-1996). Their results were compared, and the simulation results showed that PM2.5 was an important indicator for air quality and the evaluation results of the new Air Quality Standards were more scientific than the old ones. The haze-fog pollution situation in Beijing City was also analyzed based on these results, and the corresponding management measures were suggested.

  10. Evaluating computational models of cholesterol metabolism.

    Science.gov (United States)

    Paalvast, Yared; Kuivenhoven, Jan Albert; Groen, Albert K

    2015-10-01

    Regulation of cholesterol homeostasis has been studied extensively during the last decades. Many of the metabolic pathways involved have been discovered. Yet important gaps in our knowledge remain. For example, knowledge on intracellular cholesterol traffic and its relation to the regulation of cholesterol synthesis and plasma cholesterol levels is incomplete. One way of addressing the remaining questions is by making use of computational models. Here, we critically evaluate existing computational models of cholesterol metabolism making use of ordinary differential equations and addressed whether they used assumptions and make predictions in line with current knowledge on cholesterol homeostasis. Having studied the results described by the authors, we have also tested their models. This was done primarily by testing the effect of statin treatment in each model. Ten out of eleven models tested have made assumptions in line with current knowledge of cholesterol metabolism. Three out of the ten remaining models made correct predictions, i.e. predicting a decrease in plasma total and LDL cholesterol or increased uptake of LDL upon treatment upon the use of statins. In conclusion, few models on cholesterol metabolism are able to pass a functional test. Apparently most models have not undergone the critical iterative systems biology cycle of validation. We expect modeling of cholesterol metabolism to go through many more model topologies and iterative cycles and welcome the increased understanding of cholesterol metabolism these are likely to bring.

  11. Evaluation of a Mysis bioenergetics model

    Science.gov (United States)

    Chipps, S.R.; Bennett, D.H.

    2002-01-01

    Direct approaches for estimating the feeding rate of the opossum shrimp Mysis relicta can be hampered by variable gut residence time (evacuation rate models) and non-linear functional responses (clearance rate models). Bioenergetics modeling provides an alternative method, but the reliability of this approach needs to be evaluated using independent measures of growth and food consumption. In this study, we measured growth and food consumption for M. relicta and compared experimental results with those predicted from a Mysis bioenergetics model. For Mysis reared at 10??C, model predictions were not significantly different from observed values. Moreover, decomposition of mean square error indicated that 70% of the variation between model predictions and observed values was attributable to random error. On average, model predictions were within 12% of observed values. A sensitivity analysis revealed that Mysis respiration and prey energy density were the most sensitive parameters affecting model output. By accounting for uncertainty (95% CLs) in Mysis respiration, we observed a significant improvement in the accuracy of model output (within 5% of observed values), illustrating the importance of sensitive input parameters for model performance. These findings help corroborate the Mysis bioenergetics model and demonstrate the usefulness of this approach for estimating Mysis feeding rate.

  12. Model evaluation methodology applicable to environmental assessment models

    Energy Technology Data Exchange (ETDEWEB)

    Shaeffer, D.L.

    1979-08-01

    A model evaluation methodology is presented to provide a systematic framework within which the adequacy of environmental assessment models might be examined. The necessity for such a tool is motivated by the widespread use of models for predicting the environmental consequences of various human activities and by the reliance on these model predictions for deciding whether a particular activity requires the deployment of costly control measures. Consequently, the uncertainty associated with prediction must be established for the use of such models. The methodology presented here consists of six major tasks: model examination, algorithm examination, data evaluation, sensitivity analyses, validation studies, and code comparison. This methodology is presented in the form of a flowchart to show the logical interrelatedness of the various tasks. Emphasis has been placed on identifying those parameters which are most important in determining the predictive outputs of a model. Importance has been attached to the process of collecting quality data. A method has been developed for analyzing multiplicative chain models when the input parameters are statistically independent and lognormally distributed. Latin hypercube sampling has been offered as a promising candidate for doing sensitivity analyses. Several different ways of viewing the validity of a model have been presented. Criteria are presented for selecting models for environmental assessment purposes.

  13. Evaluation of the Effective Factors on Customers' Satisfaction Using INDSAT Model; Case Study: Household Appliances' Customers of Mobarakeh Steel Company

    Directory of Open Access Journals (Sweden)

    Ali Kazemi

    2012-12-01

    Full Text Available Customers and consumers are always looking for suppliers who offer better products or services to their clients. Lots of documents show that in today's competitive world, exploring and meeting customers' needs and and requirements before other competitors, is the essential condition for companies to be successful. vices provided by organizations is the assessment of customer satisfaction. this study deals with identification and investigation of factors affecting industrial customer's satisfaction at Mobarake Steel Company of Esfahan. Statistical population included 125 company of the Household Appliances' Customers of Mobarakeh Steel Company. Field methods and questionnaire were used to gather essential information. In this study, 161 questionnaires were randomly distributed to Customers. Eventually 117 questionnaires were returned. SPSS and Amos were used to analyze data descriptively, assess the credibility of the model and test hypotheses. Results indicated that all satisfaction factors (product- sales people- product-related information- order handling- technical services- interaction with supplier's internal staff- complaint handling as the aspects of have positive effects on overall customer satisfaction. Also, all of these factors are not of the same preference to the customers; sales staff and product satisfactions the scored highest and complaint handling the lowest.

  14. Evaluating the Scenic Beauty of Individual Trees: A Case Study Using a Nonlinear Model for a Pinus Tabulaeformis Scenic Forest in Beijing, China

    Directory of Open Access Journals (Sweden)

    Bin Mao

    2015-06-01

    Full Text Available The relationship between scenic beauty grade and measured tree indicators was studied through evaluation of 427 photos of individual Pinus tabulaeformis trees by using the scenic beauty estimation (SBE method. Thirteen indices to reflect trunk, crown and stem-to-canopy ratios of individual trees were evaluated by invited students. Results showed that students preferred large diameters at breast height, full canopies and straight stems or some trees with minor crook stems. Tree height had a minor contribution to individual tree quality. Correlation analysis and factor analysis were employed to select indices and to integrate them into a comprehensive index. The stepwise method of nonlinear model incorporation of four comprehensive indices—tree crown form, stem-crown coordination, tree growth and stem for—were proven valuable in order to evaluate the scenic beauty of individual trees.

  15. A comparison of the soil loss evaluation index and the RUSLE Model: a case study in the Loess Plateau of China

    Science.gov (United States)

    Zhao, W. W.; Fu, B. J.; Chen, L. D.

    2012-02-01

    The development of new methods to examine the influence of land use on soil erosion is currently a popular research topic in contemporary research. The multiscale Soil Loss Evaluation Index is a new, simple soil erosion model that can be used to evaluate the relationship between land use and soil erosion; however, applications of this model have been limited, and a comparison with other soil erosion models is needed. In this study, we used the Yanhe watershed in China's Loess Plateau as a case study to calculate the Soil Loss Evaluation Index at the small watershed scale (SLsw), to identify the similarities and differences between results from the Soil Loss Evaluation Index and the Revised Universal Soil Loss Equation (RUSLE), and to determine the key location where land use patterns need to be optimized in the study area. The procedure for calculating the SLsw, namely, using the delineation of the drainage network and the sub-watersheds as starting points, includes the calculation of soil loss horizontal distance index, the soil loss vertical distance index, slope steepness factor, rainfall-runoff erosivity factor, soil erodibility factor, and cover and management practices factor. During the calculation procedure, several functions within geographic information system (GIS), especially the spatial analyst function, are used to calculate these factors layers, and many of the data are expressed in grid format. Moreover, The AVSWAT2000 hydrological model and upscaling methods were used to calculate some of the factors in this study. When comparing the SLsw with the RUSLE, some similarities and differences were discovered. The similarities of the two models include the following: (1) both use GIS techniques at the watershed scale, (2) the same factors appear in both models, (3) and the resolution of the basic data is closely related to the evaluation results. The differences between the SLsw and the RUSLE are as follows: (1) they have different outcomes, namely, the

  16. A comparison of the soil loss evaluation index and the RUSLE Model: a case study in the Loess Plateau of China

    Directory of Open Access Journals (Sweden)

    W. W. Zhao

    2012-02-01

    Full Text Available The development of new methods to examine the influence of land use on soil erosion is currently a popular research topic in contemporary research. The multiscale Soil Loss Evaluation Index is a new, simple soil erosion model that can be used to evaluate the relationship between land use and soil erosion; however, applications of this model have been limited, and a comparison with other soil erosion models is needed.

    In this study, we used the Yanhe watershed in China's Loess Plateau as a case study to calculate the Soil Loss Evaluation Index at the small watershed scale (SLsw, to identify the similarities and differences between results from the Soil Loss Evaluation Index and the Revised Universal Soil Loss Equation (RUSLE, and to determine the key location where land use patterns need to be optimized in the study area.

    The procedure for calculating the SLsw, namely, using the delineation of the drainage network and the sub-watersheds as starting points, includes the calculation of soil loss horizontal distance index, the soil loss vertical distance index, slope steepness factor, rainfall-runoff erosivity factor, soil erodibility factor, and cover and management practices factor. During the calculation procedure, several functions within geographic information system (GIS, especially the spatial analyst function, are used to calculate these factors layers, and many of the data are expressed in grid format. Moreover, The AVSWAT2000 hydrological model and upscaling methods were used to calculate some of the factors in this study.

    When comparing the SLsw with the RUSLE, some similarities and differences were discovered. The similarities of the two models include the following: (1 both use GIS techniques at the watershed scale, (2 the same factors appear in both models, (3 and the resolution of the basic data is closely related to the evaluation results. The differences between the SL

  17. Chapter three--Syrian hamster as an animal model to study oncolytic adenoviruses and to evaluate the efficacy of antiviral compounds.

    Science.gov (United States)

    Wold, William S M; Toth, Karoly

    2012-01-01

    The Syrian (golden) hamster (Mesocricetus auratus) has served as a useful model for different aspects of biology for at least 50 years, and its use has been expanding recently. In earlier years, among other things, it was a model for cancer development. More recently, it has become a model for many different infectious diseases. It has also become an alternative model for the study of oncolytic adenovirus vectors for cancer gene therapy. Among several other human pathogens, the hamster is permissive for the replication of human species C adenoviruses, which are the parental virus for the majority of adenovirus vectors in use today. These vectors replicate in some of the established hamster tumor cell lines that can be used to generate tumors in vivo, that is, one can study oncolytic (replication competent) adenoviruses in a permissive, immunocompetent model. This has afforded the opportunity to study the effect of the host immune system on the vector-infected tumor and has allowed the use of a more relevant animal model to determine the safety and biodistribution of replication-competent adenoviruses. The hamster has also been used to evaluate antiviral compounds and vaccines against many viruses, including adenoviruses, flaviviruses, alphaviruses, arenaviruses, bunyaviruses, and paramyxoviruses.

  18. Evaluation of habitat suitability index models by global sensitivity and uncertainty analyses: a case study for submerged aquatic vegetation.

    Science.gov (United States)

    Zajac, Zuzanna; Stith, Bradley; Bowling, Andrea C; Langtimm, Catherine A; Swain, Eric D

    2015-07-01

    Habitat suitability index (HSI) models are commonly used to predict habitat quality and species distributions and are used to develop biological surveys, assess reserve and management priorities, and anticipate possible change under different management or climate change scenarios. Important management decisions may be based on model results, often without a clear understanding of the level of uncertainty associated with model outputs. We present an integrated methodology to assess the propagation of uncertainty from both inputs and structure of the HSI models on model outputs (uncertainty analysis: UA) and relative importance of uncertain model inputs and their interactions on the model output uncertainty (global sensitivity analysis: GSA). We illustrate the GSA/UA framework using simulated hydrology input data from a hydrodynamic model representing sea level changes and HSI models for two species of submerged aquatic vegetation (SAV) in southwest Everglades National Park: Vallisneria americana (tape grass) and Halodule wrightii (shoal grass). We found considerable spatial variation in uncertainty for both species, but distributions of HSI scores still allowed discrimination of sites with good versus poor conditions. Ranking of input parameter sensitivities also varied spatially for both species, with high habitat quality sites showing higher sensitivity to different parameters than low-quality sites. HSI models may be especially useful when species distribution data are unavailable, providing means of exploiting widely available environmental datasets to model past, current, and future habitat conditions. The GSA/UA approach provides a general method for better understanding HSI model dynamics, the spatial and temporal variation in uncertainties, and the parameters that contribute most to model uncertainty. Including an uncertainty and sensitivity analysis in modeling efforts as part of the decision-making framework will result in better-informed, more robust

  19. Evaluation of habitat suitability index models by global sensitivity and uncertainty analyses: a case study for submerged aquatic vegetation

    Science.gov (United States)

    Zajac, Zuzanna; Stith, Bradley M.; Bowling, Andrea C.; Langtimm, Catherine A.; Swain, Eric D.

    2015-01-01

    Habitat suitability index (HSI) models are commonly used to predict habitat quality and species distributions and are used to develop biological surveys, assess reserve and management priorities, and anticipate possible change under different management or climate change scenarios. Important management decisions may be based on model results, often without a clear understanding of the level of uncertainty associated with model outputs. We present an integrated methodology to assess the propagation of uncertainty from both inputs and structure of the HSI models on model outputs (uncertainty analysis: UA) and relative importance of uncertain model inputs and their interactions on the model output uncertainty (global sensitivity analysis: GSA). We illustrate the GSA/UA framework using simulated hydrology input data from a hydrodynamic model representing sea level changes and HSI models for two species of submerged aquatic vegetation (SAV) in southwest Everglades National Park: Vallisneria americana (tape grass) and Halodule wrightii (shoal grass). We found considerable spatial variation in uncertainty for both species, but distributions of HSI scores still allowed discrimination of sites with good versus poor conditions. Ranking of input parameter sensitivities also varied spatially for both species, with high habitat quality sites showing higher sensitivity to different parameters than low-quality sites. HSI models may be especially useful when species distribution data are unavailable, providing means of exploiting widely available environmental datasets to model past, current, and future habitat conditions. The GSA/UA approach provides a general method for better understanding HSI model dynamics, the spatial and temporal variation in uncertainties, and the parameters that contribute most to model uncertainty. Including an uncertainty and sensitivity analysis in modeling efforts as part of the decision-making framework will result in better-informed, more robust

  20. Evaluation of ASTER and SRTM DEM data for lahar modeling: A case study on lahars from Popocatépetl Volcano, Mexico

    Science.gov (United States)

    Huggel, C.; Schneider, D.; Miranda, P. Julio; Delgado Granados, H.; Kääb, A.

    2008-02-01

    Lahars are among the most serious and far-reaching volcanic hazards. In regions with potential interactions of lahars with populated areas and human structures the assessment of the related hazards is crucial for undertaking appropriate mitigating actions and reduce the associated risks. Modeling of lahars has become an important tool in such assessments, in particular where the geologic record of past events is insufficient. Mass-flow modeling strongly relies on digital terrain data. Availability of digital elevation models (DEMs), however, is often limited and thus an obstacle to lahar modeling. Remote-sensing technology has now opened new perspectives in generating DEMs. In this study, we evaluate the feasibility of DEMs derived from the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) and the Shuttle Radar Topography Mission (SRTM) for lahar modeling on Popocatépetl Volcano, Mexico. Two GIS-based models are used for lahar modeling, LAHARZ and a flow-routing-based debris-flow model (modified single-flow direction model, MSF), both predicting areas potentially affected by lahars. Results of the lahar modeling show that both the ASTER and SRTM DEMs are basically suitable for use with LAHARZ and MSF. Flow-path prediction is found to be more reliable with SRTM data, though with a coarser spatial resolution. Errors of the ASTER DEM affecting the prediction of flow paths due to the sensor geometry are associated with deeply incised gorges with north-facing slopes. LAHARZ is more sensitive to errors of the ASTER DEM than the MSF model. Lahar modeling with the ASTER DEM results in a more finely spaced predicted inundation area but does not add any significant information in comparison with the SRTM DEM. Lahars at Popocatépetl are modeled with volumes of 1 × 10 5 to 8 × 10 6 m 3 based on ice-melt scenarios of the glaciers on top of the volcano and data on recent and historical lahar events. As regards recently observed lahars, the travel

  1. Digital Library Evaluation, User Studies

    OpenAIRE

    Wildemuth, Barbara M.; Pomerantz, Jeffrey P.

    2009-01-01

    While a number of kinds of evaluation/research studies may be conducted during the design and development of a digital library (e.g., usability testing), this module is concerned with methods for evaluating the outcomes, impacts, or benefits of a digital library, including cost/benefit analyses. It also includes methods that are useful for general user studies (i.e., studies that intend to more fully understand people's interactions with digital libraries). While some methods covered here are...

  2. Reporting guidelines for modelling studies

    Directory of Open Access Journals (Sweden)

    Bennett Carol

    2012-11-01

    Full Text Available Abstract Background Modelling studies are used widely to help inform decisions about health care and policy and their use is increasing. However, in order for modelling to gain strength as a tool for health policy, it is critical that key model factors are transparent so that users of models can have a clear understanding of the model and its limitations.Reporting guidelines are evidence-based tools that specify minimum criteria for authors to report their research such that readers can both critically appraise and interpret study findings. This study was conducted to determine whether there is an unmet need for population modelling reporting guidelines. Methods We conducted a review of the literature to identify: 1 guidance for reporting population modelling studies; and, 2 evidence on the quality of reporting of population modelling studies. Guidance for reporting was analysed using a thematic approach and the data was summarised as frequencies. Evidence on the quality of reporting was reviewed and summarized descriptively. Results There were no guidelines that specifically addressed the reporting of population modelling studies. We identified a number of reporting guidelines for economic evaluation studies, some of which had sections that were relevant population modelling studies. Amongst seven relevant records, we identified 69 quality criteria that have distinct reporting characteristics. We identified two papers that addressed reporting practices of modelling studies. Overall, with the exception of describing the data used for calibration, there was little consistency in reporting. Conclusions While numerous guidelines exist for developing and evaluating health technology assessment and economic evaluation models, which by extension could be applicable to population modelling studies, there is variation in their comprehensiveness and in the consistency of reporting these methods. Population modelling studies may be an area which would

  3. Swedish student nurses' perception of peer learning as an educational model during clinical practice in a hospital setting-an evaluation study.

    Science.gov (United States)

    Stenberg, Marie; Carlson, Elisabeth

    2015-01-01

    Peer learning, a collaborative learning model has no tradition in clinical education for undergraduate student nurses in Sweden, and little is reported of the student experience. An increasing number of students have led to a pressing need for preceptors and clinical placements thus, highlighting the need for a supportive educational model. The objectives for the current study were to explore how student nurses' evaluated peer learning as an educational model during clinical practice in a hospital setting, and to compare perceptions among student nurses from year one and three. A questionnaire developed for the purpose of this study was developed and responded to by 62 (year one) and 73 (year three) student nurses. Data were collected between 2011 and 2013. The questionnaire contained six open- ended and eight closed questions on a four point Likert-scale. Written responses were analysed by content analysis and the closed questions by using descriptive statistics. Mann-Whitney U-test was used to examine differences in relation to students from year one and three. The peer learning experience was evaluated in a positive way. Statistical significance differences were shown for two out of eight closed questions. The peer learning activities were evaluated as supportive and relevant for learning. Three categories emerged from the content analysis: "a feeling of safety", "a sense of competition" and "the learning experience". A feeling of safety seems to be connected to students' perception of increased learning and independence. However, the sense of negative competition needs to be addressed when students are prepared for the teaching and learning activities in the peer learning model. Finally, what needs to be further investigated is what challenges and opportunities the peer learning model presents to preceptors.

  4. Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics.

    Science.gov (United States)

    Nguyen, Tht; Mouksassi, M-S; Holford, N; Al-Huniti, N; Freedman, I; Hooker, A C; John, J; Karlsson, M O; Mould, D R; Pérez Ruixo, J J; Plan, E L; Savic, R; van Hasselt, Jgc; Weber, B; Zhou, C; Comets, E; Mentré, F

    2017-02-01

    This article represents the first in a series of tutorials on model evaluation in nonlinear mixed effect models (NLMEMs), from the International Society of Pharmacometrics (ISoP) Model Evaluation Group. Numerous tools are available for evaluation of NLMEM, with a particular emphasis on visual assessment. This first basic tutorial focuses on presenting graphical evaluation tools of NLMEM for continuous data. It illustrates graphs for correct or misspecified models, discusses their pros and cons, and recalls the definition of metrics used.

  5. Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics

    Science.gov (United States)

    Nguyen, THT; Mouksassi, M‐S; Holford, N; Al‐Huniti, N; Freedman, I; Hooker, AC; John, J; Karlsson, MO; Mould, DR; Pérez Ruixo, JJ; Plan, EL; Savic, R; van Hasselt, JGC; Weber, B; Zhou, C; Comets, E

    2017-01-01

    This article represents the first in a series of tutorials on model evaluation in nonlinear mixed effect models (NLMEMs), from the International Society of Pharmacometrics (ISoP) Model Evaluation Group. Numerous tools are available for evaluation of NLMEM, with a particular emphasis on visual assessment. This first basic tutorial focuses on presenting graphical evaluation tools of NLMEM for continuous data. It illustrates graphs for correct or misspecified models, discusses their pros and cons, and recalls the definition of metrics used. PMID:27884052

  6. Complex Evaluation Model of Corporate Energy Management

    OpenAIRE

    Ágnes Kádár Horváth

    2014-01-01

    With the ever increasing energy problems at the doorstep alongside with political, economic, social and environmental challenges, conscious energy management has become of increasing importance in corporate resource management. Rising energy costs, stricter environmental and climate regulations as well as considerable changes in the energy market require companies to rationalise their energy consumption and cut energy costs. This study presents a complex evaluation model of corporate energy m...

  7. Evaluation of a large-scale forest scenario model in heterogeneous forests: a case study for Switzerland

    NARCIS (Netherlands)

    Thürig, E.; Schelhaas, M.J.

    2006-01-01

    Large-scale forest scenario models are widely used to simulate the development of forests and to compare the carbon balance estimates of different countries. However, as site variability in the application area often exceeds the variability in the calibration area, model validation is important. The

  8. Training evaluation models: Theory and applications

    OpenAIRE

    Carbone, V.; MORVILLO, A

    2002-01-01

    This chapter has the following aims: 1. Compare the various conceptual models for evaluation, identifying their strengths and weaknesses; 2. Define an evaluation model consistent with the aims and constraints of the fit project; 3. Describe, in critical fashion, operative tools for evaluating training which are reliable, flexible and analytical.

  9. 园林美学评价的心理结构模型研究%Study on the Psychological Structure Model for Gardens Landscape Aesthetics Evaluation

    Institute of Scientific and Technical Information of China (English)

    吴余青; 熊兴耀

    2015-01-01

    Landscape aesthetic evaluation is of vital significance for the development of landscape design and engineering.Research on aesthetic evaluation system is an interdisciplinary study, including the discipline of aes-thetic psychology as a significant part.This paper focused on the psychological structure model for landscape aes-thetic comprehensive evaluation using the structural equation model, and the results showed that the structural mod-el composed of the four aspects of index system, i.e., the fitting degree of theme, ecological suitability, sense of visual beauty and sense of comprehensive beauty, performed well in the landscape aesthetic comprehensive evalua-tion for the landscape aesthetic psychological.An empirical research based on the sampling survey of Humble Administrator's Garden verified that the model has a good reliability.%园林美学评价对园林设计与工程发展具有重要的意义,而美学评价体系是一个多学科相互渗透融合的领域,其中心理学的感受至关重要.本文以结构方程模型为工具,对园林美学综合评价的心理结构模型进行研究.结果表明,以主题符合度、生态适宜度、视觉美感度及综合美感度4个指标体系构成的园林美学评价心理结构模型可以较好地对园林美学进行综合评价.以拙政园为实例,证实了该模型具有较好的可靠性.

  10. Implementing an interprofessional model of self-management support across a community workforce: A mixed-methods evaluation study.

    Science.gov (United States)

    Kulnik, Stefan Tino; Pöstges, Heide; Brimicombe, Lucinda; Hammond, John; Jones, Fiona

    2017-01-01

    The importance of implementing self-management support (SMS) is now widely accepted, but questions remain as to how. In 2015, we facilitated the implementation of an interprofessional model of SMS (Bridges Self-Management) for people with complex multiple long-term conditions through community rehabilitation and social care services in one Southeast England locality. Over 90 professionals and support workers from this workforce received interprofessional training to integrate SMS into their care and rehabilitation interactions. This gave an opportunity to explore how SMS can be implemented in practice. We conducted a mixed-methods study with unequal weighting (qualitative emphasis), concurrent timing, and embedded design. Staff provided written feedback and case reflections, participated in group discussions, and completed a survey of self-management beliefs and attitudes. We recruited a convenience sample of 10 service users and conducted qualitative interviews and standardised questionnaires. Findings showed that staff appreciated and benefited from the interprofessional learning environment. Staff reported changes in their interactions with service users and colleagues and had gained knowledge and confidence to support individuals to self-manage. Data also highlighted the need to facilitate SMS practice at the level of service organisation. Service user data illustrated the impact of interactions with staff, and how SMS had increased service users' confidence and encouraged different skills to manage life with their conditions. This project has shown how multi-agency community teams can benefit from interprofessional training to enhance SMS for people living with long-term conditions, build a shared understanding of SMS, and integrate effective SMS strategies into everyday practices.

  11. A single-center study evaluating the effect of the controlled adverse environment (CAEsm model on tear film stability

    Directory of Open Access Journals (Sweden)

    Abelson R

    2012-11-01

    Full Text Available Richard Abelson,1,2 Keith J Lane,3 John Rodriguez,3 Patrick Johnston,3 Endri Angjeli,3 George Ousler,3 Douglas Montgomery11School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, 2Statistics and Data Corporation, Tempe, AZ; 3Ora, Inc, Andover, MA, USAPurpose: To investigate use of an improved ocular tear film analysis protocol (OPI 2.0 in the Controlled Adverse Environment (CAESM model of dry eye disease, and to examine the utility of new metrics in the identification of subpopulations of dry eye patients.Methods: Thirty-three dry eye subjects completed a single-center, single-visit, pilot CAE study. The primary endpoint was mean break-up area (MBA as assessed by the OPI 2.0 system. Secondary endpoints included corneal fluorescein staining, tear film break-up time, and OPI 2.0 system measurements. Subjects were also asked to rate their ocular discomfort throughout the CAE. Dry eye endpoints were measured at baseline, immediately following a 90-minute CAE exposure, and again 30 minutes after exposure.Results: The post-CAE measurements of MBA showed a statistically significant decrease from the baseline measurements. The decrease was relatively specific to those patients with moderate to severe dry eye, as measured by baseline MBA. Secondary endpoints including palpebral fissure size, corneal staining, and redness, also showed significant changes when pre- and post-CAE measurements were compared. A correlation analysis identified specific associations between MBA, blink rate, and palpebral fissure size. Comparison of MBA responses allowed us to identify subpopulations of subjects who exhibited different compensatory mechanisms in response to CAE challenge. Of note, none of the measures of tear film break-up time showed statistically significant changes or correlations in pre-, versus post-CAE measures.Conclusion: This pilot study confirms that the tear film metric MBA can detect changes in the ocular surface

  12. Evaluating land cover influences on model uncertainties—A case study of cropland carbon dynamics in the Mid-Continent Intensive Campaign region

    Science.gov (United States)

    Li, Zhengpeng; Liu, Shuguang; Zhang, Xuesong; West, Tristram O.; Ogle, Stephen M.; Zhou, Naijun

    2016-01-01

    Quantifying spatial and temporal patterns of carbon sources and sinks and their uncertainties across agriculture-dominated areas remains challenging for understanding regional carbon cycles. Characteristics of local land cover inputs could impact the regional carbon estimates but the effect has not been fully evaluated in the past. Within the North American Carbon Program Mid-Continent Intensive (MCI) Campaign, three models were developed to estimate carbon fluxes on croplands: an inventory-based model, the Environmental Policy Integrated Climate (EPIC) model, and the General Ensemble biogeochemical Modeling System (GEMS) model. They all provided estimates of three major carbon fluxes on cropland: net primary production (NPP), net ecosystem production (NEP), and soil organic carbon (SOC) change. Using data mining and spatial statistics, we studied the spatial distribution of the carbon fluxes uncertainties and the relationships between the uncertainties and the land cover characteristics. Results indicated that uncertainties for all three carbon fluxes were not randomly distributed, but instead formed multiple clusters within the MCI region. We investigated the impacts of three land cover characteristics on the fluxes uncertainties: cropland percentage, cropland richness and cropland diversity. The results indicated that cropland percentage significantly influenced the uncertainties of NPP and NEP, but not on the uncertainties of SOC change. Greater uncertainties of NPP and NEP were found in counties with small cropland percentage than the counties with large cropland percentage. Cropland species richness and diversity also showed negative correlations with the model uncertainties. Our study demonstrated that the land cover characteristics contributed to the uncertainties of regional carbon fluxes estimates. The approaches we used in this study can be applied to other ecosystem models to identify the areas with high uncertainties and where models can be improved to

  13. Initial study of biexponential model of intravoxel incoherent motion magnetic resonance imaging in evaluation of the liver fibrosis

    Institute of Scientific and Technical Information of China (English)

    Chen Cuiyun; Wang Bin; Shi Dapeng; Fu Fangfang; Zhang Jiliang; Wen Zejun; Zhu Shaocheng

    2014-01-01

    Background The diagnosis of liver fibrosis is a difficult task at any time using conventional clinical imaging.Intravoxel incoherent motion (IVIM) can be used to investigate both diffusion and perfusion changes in tissues.This study was designed to determine the value of IVIM in the diagnosis and staging of liver fibrosis.Methods IVIM examinations were performed on a GE 3.0T MR scanner in 25 patients with liver fibrosis and 25 healthy volunteers as the control group.Patients with liver fibrosis diagnosis were confirmed by pathology and staged on a scale of F0-4.The standard ADC values and the values of a biexponential model (slow ADC (Dslow),fast ADC (Dfast) and fraction of fast ADC (FF)) were measured in three liver regions per person.The mean standard ADC values,Dslow values,Dfast values and FF values from the study group were compared among the right posterior hepatic lobe,right anterior hepatic lobe and medial segment of the left lobe.Receiver Operating Characteristic (ROC) curves and independent-samples t-tests were used to calculate the mean standard ADC values,Dslow values,Dfast values and FF values from the study group and the control group.Spearman rho correlation analysis was used for the stage of liver fibrosis.The liver fibrosis stages between the groups F0-1 and F2-4,the groups F0-2 and F3-4 were compared.Results Among the liver fibrosis,there was no significant difference in the mean standard ADC values,Dslow values,Dfast values,and FF values obtained from the right posterior hepatic lobe,right anterior hepatic lobe and medial segment of the left lobe.Using ROC analysis,the Area Under the Curve (AUC) values of standard ADC,Dslow,Dfast,FF were all between 0.7 to 0.9.The mean standard ADC values,Dslow values,Dfast values and FF values of the liver in the study group were significantly lower than the values in the control group (P <0.05).As the stage of the fibrosis increased,the values decreased by Spearman rho correlation analysis.The mean values

  14. Evaluation of a technology-enhanced integrated care model for frail older persons: protocol of the SPEC study, a stepped-wedge cluster randomized trial in nursing homes.

    Science.gov (United States)

    Kim, Hongsoo; Park, Yeon-Hwan; Jung, Young-Il; Choi, Hyoungshim; Lee, Seyune; Kim, Gi-Soo; Yang, Dong-Wook; Paik, Myunghee Cho; Lee, Tae-Jin

    2017-04-18

    Limited evidence exists on the effectiveness of the chronic care model for people with multimorbidity. This study aims to evaluate the effectiveness of an information and communication technology- (ICT-)enhanced integrated care model, called Systems for Person-centered Elder Care (SPEC), for frail older adults at nursing homes. SPEC is a prospective stepped-wedge cluster randomized trial conducted at 10 nursing homes in South Korea. Residents aged 65 or older meeting the inclusion/exclusion criteria in all the homes are eligible to participate. The multifaceted SPEC intervention, a geriatric care model guided by the chronic care model, consists of five components: comprehensive geriatric assessment for need/risk profiling, individual need-based care planning, interdisciplinary case conferences, person-centered care coordination, and a cloud-based information and communications technology (ICT) tool supporting the intervention process. The primary outcome is quality of care for older residents using a composite measure of quality indicators from the interRAI LTCF assessment system. Outcome assessors and data analysts will be blinded to group assignment. Secondary outcomes include quality of life, healthcare utilization, and cost. Process evaluation will be also conducted. This study is expected to provide important new evidence on the effectiveness, cost-effectiveness, and implementation process of an ICT-supported chronic care model for older persons with multiple chronic illnesses. The SPEC intervention is also unique as the first registered trial implementing an integrated care model using technology to promote person-centered care for frail older nursing home residents in South Korea, where formal LTC was recently introduced. ISRCTN11972147.

  15. Light absorption by pollution, dust, and biomass burning aerosols. A global model study and evaluation with AERONET measurements

    Energy Technology Data Exchange (ETDEWEB)

    Chin, Mian; Holben, B.N. [NASA Goddard Space Flight Center, Greenbelt, MD (United States). Lab. for Atmospheres; Diehl, T.; Eck, T.F. [NASA Goddard Space Flight Center, Greenbelt, MD (United States). Lab. for Atmospheres; Maryland Univ., Baltimore County, MD (United States); Dubovik, O. [Univ. de Lille 1/CNRS, Villeneuve d' Ascq (France). Lab. d' Optique Atmospherique; Sinyuk, A. [NASA Goddard Space Flight Center, Greenbelt, MD (United States). Lab. for Atmospheres; Science Systems and Applications, Inc., Lanham, MD (United States); Streets, D.G. [Argonne National Lab., Argonne, IL (United States)

    2009-07-01

    Atmospheric aerosol distributions from 2000 to 2007 are simulated with the Goddard Chemistry Aerosol Radiation and Transport (GOCART) model to attribute light absorption by aerosol to its composition and sources from pollution, dust, and biomass burning. The 8-year, global averaged total aerosol optical depth ({tau}), absorption optical depth ({tau}{sub a}), and single scattering albedo ({omega}) at 550 nm are estimated at 0.14, 0.0086, and 0.95, respectively, with sulfate making the largest fraction of {tau} (37%), followed by dust (30%), sea salt (16%), organic matter (OM) (13%), and black carbon (BC) (4%). BC and dust account for 43% and 53% of {tau}{sub a}, respectively. From a model experiment with ''tagged'' sources, natural aerosols are estimated to be 58% of {tau} and 53% of {tau}{sub a}, with pollution and biomass burning aerosols to share the rest. Comparing with data from the surface sunphotometer network AERONET, the model tends to reproduce much better the AERONET direct measured data of {tau} and the Aangstroem exponent ({alpha}) than its retrieved quantities of {omega} and {tau}{sub a}. Relatively small in its systematic bias of {tau} for pollution and dust regions, the model tends to underestimate {tau} for biomass burning aerosols by 30-40%. The modeled {alpha} is 0.2-0.3 too low (particle too large) for pollution and dust aerosols but 0.2-0.3 too high (particle too small) for the biomass burning aerosols, indicating errors in particle size distributions in the model. Still, the model estimated {omega} is lower in dust regions and shows a much stronger wavelength dependence for biomass burning aerosols but a weaker one for pollution aerosols than those quantities from AERONET. These comparisons necessitate model improvements on aerosol size distributions, the refractive indices of dust and black carbon aerosols, and biomass burning emissions in order to better quantify the aerosol absorption in the atmosphere. (orig.)

  16. Evaluating uncertainty in simulation models

    Energy Technology Data Exchange (ETDEWEB)

    McKay, M.D.; Beckman, R.J.; Morrison, J.D.; Upton, S.C.

    1998-12-01

    The authors discussed some directions for research and development of methods for assessing simulation variability, input uncertainty, and structural model uncertainty. Variance-based measures of importance for input and simulation variables arise naturally when using the quadratic loss function of the difference between the full model prediction y and the restricted prediction {tilde y}. The concluded that generic methods for assessing structural model uncertainty do not now exist. However, methods to analyze structural uncertainty for particular classes of models, like discrete event simulation models, may be attainable.

  17. Fit-for-purpose: species distribution model performance depends on evaluation criteria -Dutch hoverflies as a case study

    NARCIS (Netherlands)

    Aguirre-Gutiérrez, J.; Carvalheiro, L.G.; Polce, C.; van Loon, E.E.; Raes, N.; Reemer, M.; Biesmeijer, J.C.

    2013-01-01

    Understanding species distributions and the factors limiting them is an important topic in ecology and conservation, including in nature reserve selection and predicting climate change impacts. While Species Distribution Models (SDM) are the main tool used for these purposes, choosing the best SDM a

  18. Fit-for-purpose: species distribution model performance depends on evaluation criteria -Dutch hoverflies as a case study

    NARCIS (Netherlands)

    Aguirre-Gutiérrez, J.; Carvalheiro, L.G.; Polce, C.; van Loon, E.E.; Raes, N.; Reemer, M.; Biesmeijer, J.C.

    2013-01-01

    Understanding species distributions and the factors limiting them is an important topic in ecology and conservation, including in nature reserve selection and predicting climate change impacts. While Species Distribution Models (SDM) are the main tool used for these purposes, choosing the best SDM

  19. Safety evaluation of sous vide-processed products with respect to nonproteolytic Clostridium botulinum by use of challenge studies and predictive microbiological models.

    Science.gov (United States)

    Hyytiä-Trees, E; Skyttä, E; Mokkila, M; Kinnunen, A; Lindström, M; Lähteenmäki, L; Ahvenainen, R; Korkeala, H

    2000-01-01

    Sixteen different types of sous vide-processed products were evaluated for safety with respect to nonproteolytic group II Clostridium botulinum by using challenge tests with low (2. 0-log-CFU/kg) and high (5.3-log-CFU/kg) inocula and two currently available predictive microbiological models, Food MicroModel (FMM) and Pathogen Modeling Program (PMP). After thermal processing, the products were stored at 4 and 8 degrees C and examined for the presence of botulinal spores and neurotoxin on the sell-by date and 7 days after the sell-by date. Most of the thermal processes were found to be inadequate for eliminating spores, even in low-inoculum samples. Only 2 of the 16 products were found to be negative for botulinal spores and neurotoxin at both sampling times. Two products at the high inoculum level showed toxigenesis during storage at 8 degrees C, one of them at the sell-by date. The predictions generated by both the FMM thermal death model and the FMM and PMP growth models were found to be inconsistent with the observed results in a majority of the challenges. The inaccurate predictions were caused by the limited number and range of the controlling factors in the models. Based on this study, it was concluded that the safety of sous vide products needs to be carefully evaluated product by product. Time-temperature combinations used in thermal treatments should be reevaluated to increase the efficiency of processing, and the use of additional antibotulinal hurdles, such as biopreservatives, should be assessed.

  20. Systems Evaluation Methods, Models, and Applications

    CERN Document Server

    Liu, Siefeng; Xie, Naiming; Yuan, Chaoqing

    2011-01-01

    A book in the Systems Evaluation, Prediction, and Decision-Making Series, Systems Evaluation: Methods, Models, and Applications covers the evolutionary course of systems evaluation methods, clearly and concisely. Outlining a wide range of methods and models, it begins by examining the method of qualitative assessment. Next, it describes the process and methods for building an index system of evaluation and considers the compared evaluation and the logical framework approach, analytic hierarchy process (AHP), and the data envelopment analysis (DEA) relative efficiency evaluation method. Unique

  1. Using multifractals to evaluate oceanographic model skill

    Science.gov (United States)

    Skákala, Jozef; Cazenave, Pierre W.; Smyth, Timothy J.; Torres, Ricardo

    2016-08-01

    We are in an era of unprecedented data volumes generated from observations and model simulations. This is particularly true from satellite Earth Observations (EO) and global scale oceanographic models. This presents us with an opportunity to evaluate large-scale oceanographic model outputs using EO data. Previous work on model skill evaluation has led to a plethora of metrics. The paper defines two new model skill evaluation metrics. The metrics are based on the theory of universal multifractals and their purpose is to measure the structural similarity between the model predictions and the EO data. The two metrics have the following advantages over the standard techniques: (a) they are scale-free and (b) they carry important part of information about how model represents different oceanographic drivers. Those two metrics are then used in the paper to evaluate the performance of the FVCOM model in the shelf seas around the south-west coast of the UK.

  2. A randomized, double blind, placebo controlled, cross over study to evaluate the analgesic activity of Boswellia serrata in healthy volunteers using mechanical pain model

    Directory of Open Access Journals (Sweden)

    K Prabhavathi

    2014-01-01

    Full Text Available Objective: Experimental pain models in human healthy volunteers are advantageous for early evaluation of analgesics. All efforts to develop nonsteroidal anti-inflammatory drugs (NSAIDs which are devoid of gastrointestinal and cardiovascular system effects are still far from achieving a breakthrough. Hence we evaluated the analgesic activity of an ayurvedic drug, Boswellia serrata by using validated human pain models which has shown its analgesic activity both in-vitro and preclinical studies to evaluate the analgesic activity of single oral dose (125 mg, 2 capsules of Boswellia serrata compared to placebo using mechanical pain model in healthy human subjects. Materials and Methods: After taking written informed consent, twelve healthy subjects were randomized (1:1 to receive single oral dose of Boswellia serrata (Shallaki® 125 mg, 2 capsules or identical placebo in a crossover design. Mechanical pain was assessed using Ugo basile analgesymeter (by Randall Selitto test at baseline and at 1 hr, 2 hrs and 3 hrs after test drug administration. Pain Threshold force and time and Pain Tolerance force and time were evaluated. Statistical analysis was done by paired t-test. Results : Twelve healthy volunteers have completed the study. Mean percentage change from baseline in Pain Threshold force and time with Boswellia serrata when compared to placebo had significantly increased [Force: 9.7 ± 11.0 vs 2.9 ± 3.4 (P = 0.05 and time: 9.7 ± 10.7 vs 2.8 ± 3.4 (P = 0.04] at third hr. Mean Percentage change from baseline in Pain Tolerance force and time with Boswellia serrata when compared to placebo had significantly (P ≤ 0.01 increased at 1 hr, 2 hrs and 3 hrs. Conclusion : In the present study, Boswellia serrata significantly increased the Pain Threshold and Pain Tolerance force and time compared to placebo. Both study medications were well tolerated. Further multiple dose studies may be needed to establish the analgesic efficacy of the drug.

  3. Evaluating a Training Using the "Four Levels Model"

    Science.gov (United States)

    Steensma, Herman; Groeneveld, Karin

    2010-01-01

    Purpose: The aims of this study are: to present a training evaluation based on the "four levels model"; to demonstrate the value of experimental designs in evaluation studies; and to take a first step in the development of an evidence-based training program. Design/methodology/approach: The Kirkpatrick four levels model was used to…

  4. Evaluating face trustworthiness: a model based approach.

    Science.gov (United States)

    Todorov, Alexander; Baron, Sean G; Oosterhof, Nikolaas N

    2008-06-01

    Judgments of trustworthiness from faces determine basic approach/avoidance responses and approximate the valence evaluation of faces that runs across multiple person judgments. Here, based on trustworthiness judgments and using a computer model for face representation, we built a model for representing face trustworthiness (study 1). Using this model, we generated novel faces with an increased range of trustworthiness and used these faces as stimuli in a functional Magnetic Resonance Imaging study (study 2). Although participants did not engage in explicit evaluation of the faces, the amygdala response changed as a function of face trustworthiness. An area in the right amygdala showed a negative linear response-as the untrustworthiness of faces increased so did the amygdala response. Areas in the left and right putamen, the latter area extended into the anterior insula, showed a similar negative linear response. The response in the left amygdala was quadratic--strongest for faces on both extremes of the trustworthiness dimension. The medial prefrontal cortex and precuneus also showed a quadratic response, but their response was strongest to faces in the middle range of the trustworthiness dimension.

  5. Identification and evaluation of reference genes for expression studies by RT-qPCR during embryonic development of the emerging model organism, Macrobrachium olfersii.

    Science.gov (United States)

    Jaramillo, Michael L; Ammar, Dib; Quispe, Ruth L; Guzman, Frank; Margis, Rogerio; Nazari, Evelise M; Müller, Yara M R

    2017-01-20

    RT-qPCR is a sensitive and highly efficient technique that is widely used in gene expression analysis and to provide insight into the molecular mechanisms underlying embryonic development. The freshwater prawn, Macrobrachium olfersii is an emerging model organism, but, the stable reference genes of this species need to be identified and validated for RT-qPCR analysis. Thus, the aim of this study was to evaluate the expression stability of six genes (β-act, GAPDH, EF-1α, RpL8, RpS6, AK) in embryos and in adult tissues (cerebral ganglia, muscle and hepatopancreas) of M. olfersii. The expression stabilities of these genes were evaluated using geNorm, NormFinder, BestKeeper, ΔCt method and integrated tool RefFinder. In the general ranking, RpL8 and RpS6 were the most stable genes in embryos, while RpS6 and RpL8 were the most stable in a combined adult tissue analysis. Analysis of the adult tissues revealed that β-act and AK were the most stable genes in cerebral ganglia, RpL8 and AK in muscle, and RpS6 and β-act in hepatopancreas. EF-1α and GAPDH were the least stable genes and as normalizer genes in RT-qPCR affected expression of the Distal-less gene during M. olfersii development. This study provides suitable reference genes for RT-qPCR analysis and allows future studies of the gene expression in M. olfersii for understanding the molecular mechanisms of their development. To our knowledge, this is the first published study that identifies and evaluates reference genes for RT-qPCR analysis in M. olfersii and could be useful as basis for evaluations of reference genes in other prawns.

  6. GROUT HOPPER MODELING STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S.

    2011-08-30

    The Saltstone facility has a grout hopper tank to provide agitator stirring of the Saltstone feed materials. The tank has about 300 gallon capacity to provide a larger working volume for the grout slurry to be held in case of a process upset, and it is equipped with a mechanical agitator, which is intended to keep the grout in motion and agitated so that it won't start to set up. The dry feeds and the salt solution are already mixed in the mixer prior to being transferred to the hopper tank. The hopper modeling study through this work will focus on fluid stirring and agitation, instead of traditional mixing in the literature, in order to keep the tank contents in motion during their residence time so that they will not be upset or solidified prior to transferring the grout to the Saltstone disposal facility. The primary objective of the work is to evaluate the flow performance for mechanical agitators to prevent vortex pull-through for an adequate stirring of the feed materials and to estimate an agitator speed which provides acceptable flow performance with a 45{sup o} pitched four-blade agitator. In addition, the power consumption required for the agitator operation was estimated. The modeling calculations were performed by taking two steps of the Computational Fluid Dynamics (CFD) modeling approach. As a first step, a simple single-stage agitator model with 45{sup o} pitched propeller blades was developed for the initial scoping analysis of the flow pattern behaviors for a range of different operating conditions. Based on the initial phase-1 results, the phase-2 model with a two-stage agitator was developed for the final performance evaluations. A series of sensitivity calculations for different designs of agitators and operating conditions have been performed to investigate the impact of key parameters on the grout hydraulic performance in a 300-gallon hopper tank. For the analysis, viscous shear was modeled by using the Bingham plastic approximation

  7. GROUT HOPPER MODELING STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S.

    2011-08-30

    The Saltstone facility has a grout hopper tank to provide agitator stirring of the Saltstone feed materials. The tank has about 300 gallon capacity to provide a larger working volume for the grout slurry to be held in case of a process upset, and it is equipped with a mechanical agitator, which is intended to keep the grout in motion and agitated so that it won't start to set up. The dry feeds and the salt solution are already mixed in the mixer prior to being transferred to the hopper tank. The hopper modeling study through this work will focus on fluid stirring and agitation, instead of traditional mixing in the literature, in order to keep the tank contents in motion during their residence time so that they will not be upset or solidified prior to transferring the grout to the Saltstone disposal facility. The primary objective of the work is to evaluate the flow performance for mechanical agitators to prevent vortex pull-through for an adequate stirring of the feed materials and to estimate an agitator speed which provides acceptable flow performance with a 45{sup o} pitched four-blade agitator. In addition, the power consumption required for the agitator operation was estimated. The modeling calculations were performed by taking two steps of the Computational Fluid Dynamics (CFD) modeling approach. As a first step, a simple single-stage agitator model with 45{sup o} pitched propeller blades was developed for the initial scoping analysis of the flow pattern behaviors for a range of different operating conditions. Based on the initial phase-1 results, the phase-2 model with a two-stage agitator was developed for the final performance evaluations. A series of sensitivity calculations for different designs of agitators and operating conditions have been performed to investigate the impact of key parameters on the grout hydraulic performance in a 300-gallon hopper tank. For the analysis, viscous shear was modeled by using the Bingham plastic approximation

  8. Evaluation Strategy Michael Porter's five forces model of the competitive environment on the dairy industry (Case Study: Amoll Haraz Dvshh dairy company

    Directory of Open Access Journals (Sweden)

    Mohammad Bolorian Tehrani

    2016-08-01

    Full Text Available State of competition in an industry depends on five basic forces. Porter's five forces model including bargaining power of customers, bargaining power of suppliers, threat of newcomers to the industry, threat of substitute products is the intensity of rivalry between competitors. Joint strength of these forces determines the ultimate benefit of potentially any industry. The purpose of this study was to evaluate the competitive environment of the dairy industry based on Michael Porter's five forces model is a dairy company.Survey, 20 of whom are chosen by simple random sampling. After collecting data through questionnaires, analyzed using SPSS software was based on the results, between each of Porter's forces, a significant relationship was found with the company's sales and market share more than other forces also affect the bargain

  9. Evaluation of periodontal risk assessment model among adults aged 30-60 years attending KLE Dental College, Belgaum: A hospital-based study

    Directory of Open Access Journals (Sweden)

    Eshwar Shruthi

    2010-01-01

    Full Text Available Aim : The aim of the present study was to evaluate the periodontal risk of individuals using the modified periodontal risk assessment model. Materials and Methods: Adult subjects aged 30-60 years attending the out patient department of Institute of Dental Sciences, Belgaum in a week′s period were screened and 30 among those who met the criteria were included in the study. Complete history and examination of the oral cavity was done using mouth mirror and community periodontal index probes. Periodontal status was recorded using community periodontal index. Systemic conditions like hypertension and diabetes was assessed by suitable investigations. All the risk factors were plotted on a model using Microsoft excel and periodontal risk was assessed based on the findings and categorized as low, moderate and high risk. Results: Among 30 patients 13 were in low risk group, 10 in moderate risk group, and 7 in high risk group identified by proposed model given by Vishwa Chandra whereas 20 patients were in low risk group, 5 in moderate risk group and 5 in high risk group when identified Lang and Tonetti model (2003. Conclusion: In conclusion the use of risk assessment tool would result in reduction of complex therapies and would prevent the future effects of periodontal disease such as bone and tooth loss.

  10. Integrating distributional, spatial prioritization, and individual-based models to evaluate potential critical habitat networks: A case study using the Northern Spotted Owl

    Science.gov (United States)

    As part of the northern spotted owl recovery planning effort, we evaluated a series of alternative critical habitat scenarios using a species-distribution model (MaxEnt), a conservation-planning model (Zonation), and an individual-based population model (HexSim). With this suite ...

  11. A Bayesian approach for evaluation of the effect of water quality model parameter uncertainty on TMDLs: A case study of Miyun Reservoir

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Shidong, E-mail: emblembl@sina.com [School of Environment, Tsinghua University, 1 Qinghuayuan, Haidian District, Beijing 100084 (China); Jia, Haifeng, E-mail: jhf@tsinghua.edu.cn [School of Environment, Tsinghua University, 1 Qinghuayuan, Haidian District, Beijing 100084 (China); Xu, Changqing, E-mail: 2008changqing@163.com [School of Environment, Tsinghua University, 1 Qinghuayuan, Haidian District, Beijing 100084 (China); Xu, Te, E-mail: xt_lichking@qq.com [School of Environment, Tsinghua University, 1 Qinghuayuan, Haidian District, Beijing 100084 (China); Melching, Charles, E-mail: steve.melching17@gmail.com [Melching Water Solutions, 4030 W. Edgerton Avenue, Greenfield, WI 53221 (United States)

    2016-08-01

    ) determination. The sources of uncertainty are discussed and ways to reduce the uncertainties are proposed. - Highlights: • Effect of water quality model parameter uncertainty on TMDLs was evaluated. • A Bayesian approach was used for the model parameter uncertainty analysis. • DREAM algorithm, a multi-chain MCMC, was used as the Bayesian approach. • Miyun Reservoir, the most important drinking water source for Beijing, was studied. • Wide ranges of allowable loads were obtained through uncertainty propagation.

  12. Industrial laser welding evaluation study

    Science.gov (United States)

    Hella, R.; Locke, E.; Ream, S.

    1974-01-01

    High power laser welding was evaluated for fabricating space vehicle boosters. This evaluation was made for 1/4 in. and 1/2 in. aluminum (2219) and 1/4 in. and 1/2 in. D6AC steel. The Avco HPL 10 kW industrial laser was used to perform the evaluation. The objective has been achieved through the completion of the following technical tasks: (1) parameter study to optimize welding and material parameters; (2) preparation of welded panels for MSFC evaluation; and (3) demonstration of the repeatability of laser welding equipment. In addition, the design concept for a laser welding system capable of welding large space vehicle boosters has been developed.

  13. Evaluating and Quantifying the Climate-Driven Interannual Variability in Global Inventory Modeling and Mapping Studies (GIMMS Normalized Difference Vegetation Index (NDVI3g at Global Scales

    Directory of Open Access Journals (Sweden)

    Alvaro Ivanoff

    2013-08-01

    Full Text Available Satellite observations of surface reflected solar radiation contain information about variability in the absorption of solar radiation by vegetation. Understanding the causes of variability is important for models that use these data to drive land surface fluxes or for benchmarking prognostic vegetation models. Here we evaluated the interannual variability in the new 30.5-year long global satellite-derived surface reflectance index data, Global Inventory Modeling and Mapping Studies normalized difference vegetation index (GIMMS NDVI3g. Pearson’s correlation and multiple linear stepwise regression analyses were applied to quantify the NDVI interannual variability driven by climate anomalies, and to evaluate the effects of potential interference (snow, aerosols and clouds on the NDVI signal. We found ecologically plausible strong controls on NDVI variability by antecedent precipitation and current monthly temperature with distinct spatial patterns. Precipitation correlations were strongest for temperate to tropical water limited herbaceous systems where in some regions and seasons > 40% of the NDVI variance could be explained by precipitation anomalies. Temperature correlations were strongest in northern mid- to high-latitudes in the spring and early summer where up to 70% of the NDVI variance was explained by temperature anomalies. We find that, in western and central North America, winter-spring precipitation determines early summer growth while more recent precipitation controls NDVI variability in late summer. In contrast, current or prior wet season precipitation anomalies were correlated with all months of NDVI in sub-tropical herbaceous vegetation. Snow, aerosols and clouds as well as unexplained phenomena still account for part of the NDVI variance despite corrections. Nevertheless, this study demonstrates that GIMMS NDVI3g represents real responses of vegetation to climate variability that are useful for global models.

  14. Evaluating and Quantifying the Climate-Driven Interannual Variability in Global Inventory Modeling and Mapping Studies (GIMMS) Normalized Difference Vegetation Index (NDVI3g) at Global Scales

    Science.gov (United States)

    Zeng, Fanwei; Collatz, George James; Pinzon, Jorge E.; Ivanoff, Alvaro

    2013-01-01

    Satellite observations of surface reflected solar radiation contain informationabout variability in the absorption of solar radiation by vegetation. Understanding thecauses of variability is important for models that use these data to drive land surface fluxesor for benchmarking prognostic vegetation models. Here we evaluated the interannualvariability in the new 30.5-year long global satellite-derived surface reflectance index data,Global Inventory Modeling and Mapping Studies normalized difference vegetation index(GIMMS NDVI3g). Pearsons correlation and multiple linear stepwise regression analyseswere applied to quantify the NDVI interannual variability driven by climate anomalies, andto evaluate the effects of potential interference (snow, aerosols and clouds) on the NDVIsignal. We found ecologically plausible strong controls on NDVI variability by antecedent precipitation and current monthly temperature with distinct spatial patterns. Precipitation correlations were strongest for temperate to tropical water limited herbaceous systemswhere in some regions and seasons 40 of the NDVI variance could be explained byprecipitation anomalies. Temperature correlations were strongest in northern mid- to-high-latitudes in the spring and early summer where up to 70 of the NDVI variance was explained by temperature anomalies. We find that, in western and central North America,winter-spring precipitation determines early summer growth while more recent precipitation controls NDVI variability in late summer. In contrast, current or prior wetseason precipitation anomalies were correlated with all months of NDVI in sub-tropical herbaceous vegetation. Snow, aerosols and clouds as well as unexplained phenomena still account for part of the NDVI variance despite corrections. Nevertheless, this study demonstrates that GIMMS NDVI3g represents real responses of vegetation to climate variability that are useful for global models.

  15. Use of an operational model evaluation system for model intercomparison

    Energy Technology Data Exchange (ETDEWEB)

    Foster, K. T., LLNL

    1998-03-01

    The Atmospheric Release Advisory Capability (ARAC) is a centralized emergency response system used to assess the impact from atmospheric releases of hazardous materials. As part of an on- going development program, new three-dimensional diagnostic windfield and Lagrangian particle dispersion models will soon replace ARAC`s current operational windfield and dispersion codes. A prototype model performance evaluation system has been implemented to facilitate the study of the capabilities and performance of early development versions of these new models relative to ARAC`s current operational codes. This system provides tools for both objective statistical analysis using common performance measures and for more subjective visualization of the temporal and spatial relationships of model results relative to field measurements. Supporting this system is a database of processed field experiment data (source terms and meteorological and tracer measurements) from over 100 individual tracer releases.

  16. Transport studies of ions across polystyrene based composite membrane: Evaluation of fixed charge density using theoretical models

    Science.gov (United States)

    Imteyaz, Shahla; Rafiuddin

    2016-11-01

    Polystyrene (PS) dispersed tin molybdate (TM) composite was prepared by sol-gel method. The membrane was characterized for its thermal stability by TG-DTA. SEM reveals the formation of composite material with uniform surface morphology. Crystallinity and phosphorylation of the membrane was confirmed by X-RD and FT-IR. Membrane potential of different monovalent electrolytes with varying concentration followed the order LiCl > NaCl > NH4Cl > KCl. Membrane potential increases with dilution of electrolytes confirming it to be cation selective in nature. The theoretical value of fixed charge density for the membrane was also evaluated from membrane potential using different approaches proposed by (a) Teorell-Meyer-Sievers (b) Kobatake and (c) Nagasawa, which are comparable with the experimental values. Fixed charge density examined for the electrolytes follows the order LiCl > NaCl > NH4Cl > KCl. Li+ ion shows highest value of fixed charge density in all the methods as the Donnan exclusion is highest for the electrolyte of smaller cation size. Transport number and mobility ratio for ion selectivity also increases with dilution. Membrane shows the lowest permselectivity for K+ while highest for Li+. The strong binding affinity of K+ counter-ion with fixed charge groups on the polymer decreases the membrane charge density and permselectivity. Thus, the membrane shows its applicability in various electro-membrane processes.

  17. Intracerebral hemorrhage (ICH) evaluation with a novel magnetic induction sensor: a preliminary study using the Chinese head model.

    Science.gov (United States)

    Zhang, Ziyi; Liu, Peiguo; Zhou, Dongming; Zhang, Liang; Lei, Hengdong

    2014-01-01

    Biomedical magnetic induction measurement is a promising method for the detection of intracerebral hemorrhage (ICH), especially in China. Aiming at overcoming the problem of low sensitivity, a magnetic induction sensor is chosen to replace the conventional sensors. It uses a two-arm Archimedean spiral coil as the exciter and a circular coil as the receiver. In order to carry out high-fidelity simulations, the Chinese head model with real anatomical structure is introduced into this novel sensor for the first time. Simulations have been carried out upon early stage ICH measurements. By calculating the state sensitivity and time sensitivity of the perturbation phase of two types of sensors using the electromagnetic software, we conclude that the primary signal received can be largely reduced using the novel sensor, which could effectively increase the time and state sensitivity simultaneously.

  18. RPF151, a novel capsaicin-like analogue: in vitro studies and in vivo preclinical antitumor evaluation in a breast cancer model.

    Science.gov (United States)

    Ferreira, Adilson Kleber; Tavares, Maurício Temotheo; Pasqualoto, Kerly Fernanda Mesquita; de Azevedo, Ricardo Alexandre; Teixeira, Sarah Fernandes; Ferreira-Junior, Wilson Alves; Bertin, Ariane Matiello; de-Sá-Junior, Paulo Luiz; Barbuto, José Alexandre Marzagão; Figueiredo, Carlos Rogério; Cury, Yara; Damião, Mariana Celestina Frojuello Costa Bernstorff; Parise-Filho, Roberto

    2015-09-01

    Capsaicin, the primary pungent component of the chili pepper, has antitumor activity. Herein, we describe the activity of RPF151, an alkyl sulfonamide analogue of capsaicin, against MDA-MB-231 breast cancer cells. RPF151 was synthetized, and molecular modeling was used to compare capsaicin and RPF151. Cytotoxicity of RPF151 on MDA-MB-231 was also evaluated by the 3-[4,5-dimethylthiazol-2-yl]-2,5diphenyltetrazolium bromide (MTT) assay. Cell cycle analysis, by flow cytometry, and Western blot analysis of cycle-related proteins were used to evaluate the antiproliferative mechanisms. Apoptosis was evaluated by phosphatidyl-serine externalization, cleavage of Ac-YVAD-AMC, and Bcl-2 expression. The production of reactive oxygen species was evaluated by flow cytometry. RPF151 in vivo antitumor effects were investigated in murine MDA-MB-231 model. This study shows that RPF151 downregulated p21 and cyclins A, D1, and D3, leading to S-phase arrest and apoptosis. Although RPF151 has induced the activation of TRPV-1 and TRAIL-R1/DR4 and TRAIL-2/DR5 on the surface of MDA-MB-231 cells, its in vivo antitumor activity was TRPV-1-independent, thus suggesting that RPF151 should not have the same pungency-based limitation of capsaicin. In silico analysis corroborated the biological findings, showing that RPF151 has physicochemical improvements over capsaicin. Overall, the activity of RPF151 against MDA-MB-231 and its lower pungency suggest that it may have a relevant role in cancer therapy.

  19. Evaluation of ketamine, nimodipine, gabapentin and imipramine in partial sciatic nerve transection model of neuropathic pain in rat: an experimental study.

    Science.gov (United States)

    Hota, D; Bansal, V; Pattanaik, S

    2007-09-01

    The aim of this research is to study the effects of nimodipine, gabapentin, ketamine and imipramine in the partial sciatic nerve transection (PST) model of neuropathic pain in rats. PST was produced in young Wistar rats of either sex by partial destruction of the sciatic nerve. A decrease in the latency to paw withdrawal reaction on the hot plate was considered as development of neuropathy. The drugs were given daily from the third day of the procedure, and evaluation was done on days 7, 14, 21 and 28. There was a significant decrease (p withdrawal response in the nimodipine group from day 14 onward when compared with the control group. In the ketamine and imipramine group, this response was seen from day 21 onward. The effect persisted till the end of the study. There was no improvement in the gabapentin group. The results of our study show that nimodipine (dihydropyridine calcium channel blocker), ketamine (NMDA antagonist) and imipramine (tricyclic antidepressant) modulated hyperalgesia and allodynia in the PST model of neuropathy. Gabapentin (an alpha-2 delta calcium subunit blocker) did not show any effect in this model of neuropathy. The widespread use of gabapentin in various types of neuropathic pain thus needs to be reevaluated.

  20. Data Assimilation and Model Evaluation Experiment Datasets.

    Science.gov (United States)

    Lai, Chung-Chieng A.; Qian, Wen; Glenn, Scott M.

    1994-05-01

    The Institute for Naval Oceanography, in cooperation with Naval Research Laboratories and universities, executed the Data Assimilation and Model Evaluation Experiment (DAMÉE) for the Gulf Stream region during fiscal years 1991-1993. Enormous effort has gone into the preparation of several high-quality and consistent datasets for model initialization and verification. This paper describes the preparation process, the temporal and spatial scopes, the contents, the structure, etc., of these datasets.The goal of DAMEE and the need of data for the four phases of experiment are briefly stated. The preparation of DAMEE datasets consisted of a series of processes: 1)collection of observational data; 2) analysis and interpretation; 3) interpolation using the Optimum Thermal Interpolation System package; 4) quality control and re-analysis; and 5) data archiving and software documentation.The data products from these processes included a time series of 3D fields of temperature and salinity, 2D fields of surface dynamic height and mixed-layer depth, analysis of the Gulf Stream and rings system, and bathythermograph profiles. To date, these are the most detailed and high-quality data for mesoscale ocean modeling, data assimilation, and forecasting research. Feedback from ocean modeling groups who tested this data was incorporated into its refinement.Suggestions for DAMEE data usages include 1) ocean modeling and data assimilation studies, 2) diagnosis and theorectical studies, and 3) comparisons with locally detailed observations.

  1. Use of an innovative model to evaluate mobility in seniors with lower-limb amputations of vascular origin: a pilot study

    Directory of Open Access Journals (Sweden)

    Corriveau Hélène

    2010-09-01

    Full Text Available Abstract Background The mobility of older individuals has often been only partially assessed, without considering all important aspects such as potential (available versus effective (used mobilities and the physical and psychosocial factors that modulate them. This study proposes a new model for evaluating mobility that considers all important aspects, applied here to lower-limb amputees with vascular origin. This model integrates the concepts of potential mobility (e.g. balance, speed of movement, effective mobility (e.g. life habits, movements in living areas and factors that modulate these two types of mobility (e.g. strength, sensitivity, social support, depression. The main objective was to characterize potential and effective mobility as well as mobility modulators in a small sample of people with lower-limb amputations of vascular origin with different characteristics. The second objective of this pilot study was to assess the feasibility of measuring all variables in the model in a residential context. Methods An observational and transversal design was used with a heterogeneous sample of 10 participants with a lower-limb amputation of vascular origin, aged 51 to 83, assessed between eight and 18 months after discharge from an acute care hospital. A questionnaire of participant characteristics and 16 reliable and valid measurements were used. Results The results show that the potential mobility indicators do not accurately predict effective mobility, i.e., participants who perform well on traditional measures done in the laboratory or clinic are not always those who perform well in the real world. The model generated 4 different profiles (categories of participants ranging from reduced to excellent potential mobility and low to excellent effective mobility, and characterized the modulating factors. The evaluations were acceptable in terms of the time taken (three hours and the overall measurements, with a few exceptions, which were

  2. Evaluating the Performance Improvement Preferences of Disability Service Managers: An Exploratory Study Using Gilbert's Behavior Engineering Model

    Science.gov (United States)

    Wooderson, John R.; Cuskelly, Monica; Meyer, Kim A.

    2017-01-01

    Background: Front-line managers play an important role in managing the performance of staff working in services for people with intellectual disability, but little is known about the practices they prefer to use to improve staff performance and whether these align with what research has shown to be effective. Method: This study comprised two…

  3. Comparative accuracy evaluation of fine-scale global and local digital surface models: The Tshwane Case Study I

    CSIR Research Space (South Africa)

    Breytenbach, Andre

    2016-10-01

    Full Text Available Conducted in the City of Tshwane, South Africa, this study set about to test the accuracy of DSMs derived from different remotely sensed data locally. VHR digital mapping camera stereo-pairs, tri-stereo imagery collected by a Pléiades satellite...

  4. Model quality and safety studies

    DEFF Research Database (Denmark)

    Petersen, K.E.

    1997-01-01

    The paper describes the EC initiative on model quality assessment and emphasizes some of the problems encountered in the selection of data from field tests used in the evaluation process. Further, it discusses the impact of model uncertainties in safety studies of industrial plants. The model...... that most of these have never been through a procedure of evaluation, but nonetheless are used to assist in making decisions that may directly affect the safety of the public and the environment. As a major funder of European research on major industrial hazards, DGXII is conscious of the importance......-tain model is appropriate for use in solving a given problem. Further, the findings from the REDIPHEM project related to dense gas dispersion will be highlighted. Finally, the paper will discuss the need for model quality assessment in safety studies....

  5. Flat-detector computed tomography evaluation in an experimental animal aneurysm model after endovascular treatment: A pilot study

    Science.gov (United States)

    Gölitz, Philipp; Adamek, Edyta; Royalty, Kevin; Doerfler, Arnd; Struffert, Tobias

    2015-01-01

    We compared flat-detector computed tomography angiography (FD-CTA) to multislice computed tomography (MS-CTA) and digital subtracted angiography (DSA) for the visualization of experimental aneurysms treated with stents, coils or a combination of both. In 20 rabbits, aneurysms were created using the rabbit elastase aneurysm model. Seven aneurysms were treated with coils, seven with coils and stents, and six with self-expandable stents alone. Imaging was performed by DSA, MS-CTA and FD-CTA immediately after treatment. Multiplanar reconstruction (MPR) was performed and two experienced reviewers compared aneurysm/coil package size, aneurysm occlusion, stent diameters and artifacts for each modality. In aneurysms treated with stents alone, the visualization of the aneurysms was identical in all three imaging modalities. Residual aneurysm perfusion was present in two cases and visible in DSA and FD-CTA but not in MS-CTA. The diameter of coil-packages was overestimated in MS-CT by 56% and only by 16% in FD-CTA compared to DSA (p < 0.05). The diameter of stents was identical for DSA and FD-CTA and was significantly overestimated in MS-CTA (p < 0.05). Beam/metal hardening artifacts impaired image quality more severely in MS-CTA compared to FD-CTA. MS-CTA is impaired by blooming and beam/metal hardening artifacts in the visualization of implanted devices. There was no significant difference between measurements made with noninvasive FD-CTA compared to gold standard of DSA after stenting and after coiling/stent-assisted coiling of aneurysms. FD-CTA may be considered as a non-invasive alternative to the gold standard 2D DSA in selected patients that require follow up imaging after stenting. PMID:26111985

  6. European Cohesion Policy: A Proposed Evaluation Model

    Directory of Open Access Journals (Sweden)

    Alina Bouroşu (Costăchescu

    2012-06-01

    Full Text Available The current approach of European Cohesion Policy (ECP is intended to be a bridge between different fields of study, emphasizing the intersection between "the public policy cycle, theories of new institutionalism and the new public management”. ECP can be viewed as a focal point between putting into practice the principles of the new governance theory, theories of economic convergence and divergence and the governance of common goods. After a short introduction of defining the concepts used, the author discussed on the created image of ECP by applying three different theories, focusing on the structural funds implementation system (SFIS, directing the discussion on the evaluation part of this policy, by proposing a model of performance evaluation of the system, in order to outline key principles for creating effective management mechanisms of ECP.

  7. Does Implementation Follow Design? A Case Study of a Workplace Health Promotion Program Using the 4-S Program Design and the PIPE Impact Metric Evaluation Models.

    Science.gov (United States)

    Äikäs, Antti Hermanni; Pronk, Nicolaas P; Hirvensalo, Mirja Hannele; Absetz, Pilvikki

    2017-08-01

    The aim of this study was to describe the content of a multiyear market-based workplace health promotion (WHP) program and to evaluate design and implementation processes in a real-world setting. Data was collected from the databases of the employer and the service provider. It was classified using the 4-S (Size, Scope, Scalability, and Sustainability) and PIPE Impact Metric (Penetration, Implementation) models. Data analysis utilized both qualitative and quantitative methods. Program design covered well the evidence-informed best practices except for clear path toward sustainability, cooperation with occupational health care, and support from middle-management supervisors. The penetration rate among participants was high (99%) and majority (81%) of services were implemented as designed. Study findings indicate that WHP market would benefit the use of evidence-based design principles and tendentious decisions to anticipate a long-term implementation process already during the planning phase.

  8. Synthesis, spectral characterization, molecular modeling, thermal study and biological evaluation of transition metal complexes of a bidentate Schiff base ligand.

    Science.gov (United States)

    Chandra, Sulekh; Bargujar, Savita; Nirwal, Rita; Qanungo, Kushal; Sharma, Saroj K

    2013-09-01

    Complexes of copper(II) and nickel(II) of general composition M(L)2X2, have been synthesized [where L=3-Bromoacetophenone thiosemicarbazone and X=CH3COO(-), Cl(-) and NO3(-)]. All the complexes were characterized by elemental analysis, magnetic moments, IR, electronic and EPR spectral studies. The ligand behaved as bidentate and coordinated through sulfur of -C=S group and nitrogen atoms of -C=N group. The copper(II) and nickel(II) complexes were found to have magnetic moments 1.94-2.02 BM, 2.96-3.02 BM respectively which was corresponding to one and two unpaired electrons respectively. The molar conductance of the complexes in solution of DMSO lies in the range of 10-20 Ω(-1) cm(2) mol(-1) indicating their non-electrolytic behavior. On the basis of EPR, electronic and infrared spectral studies, tetragonal geometry has been assigned for copper(II) complexes and an octahedral geometry for nickel(II) complexes. The values of Nephelauxetic parameter β lie in the range 0.19-0.37 which indicated the covalent character in metal ligand 'σ' bond. Synthesized ligand and its copper(II) and nickel(II) complexes have also been screened against different bacterial and fungal species which suggested that complexes are more active than the ligands in antimicrobial activities.

  9. Modelling the hydrologic role of glaciers within a Water Evaluation and Planning System (WEAP: a case study in the Rio Santa watershed (Peru

    Directory of Open Access Journals (Sweden)

    T. Condom

    2011-01-01

    Full Text Available For the past 30 years, a process of glacier retreat has been observed in the Andes, raising alarm among regional water resources managers. The purpose of this paper is to develop a model of the role of Andean glaciers in the hydrology of their associated watersheds, which is appropriate for application at a river basin scale, with an eye towards creating an analytical tool that can be used to assess the water management implications of possible future glacier retreat. While the paper delves deeply into our formulation of a glacier module within a water resources management modelling system, the widely subscribed Water Evaluation and Planning System (WEAP, the originality of our work lies less in the domain of glaciology and more in how we apply an existing reduced form representation of glacier evolution within a model of the climate-glacier-hydrology-water management continuum. Key insights gained pertain to appropriate ways to deploy these reduced form representations in a relatively data poor environment and to effectively integrate them into a modelling framework that places glaciers within a wider water management context. The study area is the Rio Santa watershed in Peru which contains many of the expansive glaciers of the singular Cordillera Blanca. The specific objectives of this study included: (i adequately simulating both monitored glacier retreat and observed river flows from the last forty years using historical climate time series as model input; (ii quantifying the proportion of river flow in the Rio Santa produced from melting glaciers during this period; (iii estimating the historical contribution of groundwater accretions to river flows; and (vi reproducing a reasonable simulation of recent hydropower operations in the Rio Santa system. In pursuit objective (i, a split sample calibration-validation of the model was conducted by comparing the simulated glacier area to Landsat images taken in 1987 and 1998 and observed and

  10. Radioecological Study in Natural Grasslands of Argentina. Modeling and Evaluation of the Impact on Humans and the Environment

    Energy Technology Data Exchange (ETDEWEB)

    Juri Ayub, Jimena; Velasco, Hugo; Rizzotto, Marcos G. [Grupo de Estudios Ambientales - Instituto de Matematica Aplicada San Luis (GEA-IMASL), Universidad Nacional de San Luis/CONICET, Ejercito de los Andes 950 D5700HHW, San Luis (Argentina)

    2014-07-01

    The concentration of gamma emitting radionuclides was measured in two natural grasslands (SA and SB), where soils have been undisturbed since the atmospheric {sup 137}Cs global fallout. Site SA is characterized by a small slope (<0.8 deg.) and only the grass Eragrostis curvula grows. Site SB shows a more marked slope (1.7 deg. - 2.0 deg.) where a mixture of grasses grows. Following standard procedures soil and vegetation samples were obtained. Soil profiles were collected up to 25 cm depth (slices 5 cm thickness) and 10 cm depth (0-2, 2-5 and 5-10 cm). In plants, radionuclides uptake by roots and resuspension were distinguished. In soil, {sup 40}K, {sup 226}Ra and {sup 228}Ac activity concentration ranged from 706±71 Bq kg{sup -1} to 743±74 Bq kg{sup -1}, 26±2.6 Bq kg{sup -1} to 20±2.0 Bq kg{sup -1} and 31.0±3.1 Bq kg{sup -1} to 35.2±3.6 Bq kg{sup -1}, respectively; showing a uniform vertical distribution and no differences between sites. Instead, for {sup 137}Cs, the vertical distribution is not uniform and differences between sites were found. The {sup 137}Cs activity concentration ranged from 0.37±0.04 Bq kg{sup -1} to 6.2±0.06 Bq kg{sup -1}, reaching the maximum value??in the intermediate soil layer (10-15 cm). The {sup 137}Cs deposition on soil was 0.56±0.10 kBq m{sup -2} in SA and 0.51±0.15 kBq m{sup -2} in SB. The {sup 137}Cs vertical transport in soil was described using a convection-dispersion model. The diffusion coefficients (0.43-0.96 cm{sup 2} y{sup -1} for SA and 0.67-2.27 cm{sup 2} y{sup -1} for SB) are in the range of values reported in the literature, instead the convection velocities (0.29-0.64 cm y{sup -1} for SA and 0.33-0.73 cm y{sup -1} for SB) are one order of magnitude higher. This could be due to the high sand and low fine materials content in these soils (sand > 60%, clay <8 %). In plants, {sup 137}Cs was not detected. We have not found differences in {sup 40}K content in plants between sites but differences between sampling

  11. Evaluation of how a curriculum change in nurse education was managed through the application of a business change management model: A qualitative case study.

    Science.gov (United States)

    Chowthi-Williams, Annette; Curzio, Joan; Lerman, Stephen

    2016-01-01

    Curriculum changes are a regular feature of nurse education, yet little is known about how such changes are managed. Research in this arena is yet to emerge. Evaluation of how a curriculum change in nurse education was managed through the application of a business change management model. A qualitative case study: the single case was the new curriculum, the Primary Care Pathway. One executive, three senior managers, two academics and nineteen students participated in this study in one faculty of health and social care in a higher education institution. The findings suggest that leadership was pivotal to the inception of the programme and guiding teams managed the change and did not take on a leadership role. The vision for the change and efforts to communicate it did not reach the frontline. Whilst empowerment was high amongst stakeholders and students, academics felt dis-empowered. Short-term wins were not significant in keeping up the momentum of change. The credibility of the change was under challenge and the concept of the new programme was not yet embedded in academia. Differences between the strategic and operational part of the organisation surfaced with many challenges occurring at the implementation stage. The business change model used was valuable, but was found to not be applicable during curriculum changes in nurse education. A new change model emerged, and a tool was developed alongside to aid future curriculum changes. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Evaluation of image reconstruction algorithms encompassing Time-Of-Flight and Point Spread Function modelling for quantitative cardiac PET: phantom studies.

    Science.gov (United States)

    Presotto, L; Gianolli, L; Gilardi, M C; Bettinardi, V

    2015-04-01

    To perform kinetic modelling quantification, PET dynamic data must be acquired in short frames, where different critical conditions are met. The accuracy of reconstructed images influences quantification. The added value of Time-Of-Flight (TOF) and Point Spread Function (PSF) in cardiac image reconstruction was assessed. A static phantom was used to simulate two extreme conditions: (i) the bolus passage and (ii) the steady uptake. Various count statistics and independent noise realisations were considered. A moving phantom filled with two different radionuclides was used to simulate: (i) a great range of contrasts and (ii) the cardio/respiratory motion. Analytical and iterative reconstruction (IR) algorithms also encompassing TOF and PSF modelling were evaluated. Both analytic and IR algorithms provided good results in all the evaluated conditions. The amount of bias introduced by IR was found to be limited. TOF allowed faster convergence and lower noise levels. PSF achieved near full myocardial activity recovery in static conditions. Motion degraded performances, but the addition of both TOF and PSF maintained the best overall behaviour. IR accounting for TOF and PSF can be recommended for the quantification of dynamic cardiac PET studies as they improve the results compared to analytic and standard IR.

  13. Evaluating topic models with stability

    CSIR Research Space (South Africa)

    De Waal, A

    2008-11-01

    Full Text Available on unlabelled data, so that a ground truth does not exist and (b) "soft" (probabilistic) document clusters are created by state-of-the-art topic models, which complicates comparisons even when ground truth labels are available. Perplexity has often been used...

  14. Evaluating Energy Efficiency Policies with Energy-Economy Models

    Energy Technology Data Exchange (ETDEWEB)

    Mundaca, Luis; Neij, Lena; Worrell, Ernst; McNeil, Michael A.

    2010-08-01

    The growing complexities of energy systems, environmental problems and technology markets are driving and testing most energy-economy models to their limits. To further advance bottom-up models from a multidisciplinary energy efficiency policy evaluation perspective, we review and critically analyse bottom-up energy-economy models and corresponding evaluation studies on energy efficiency policies to induce technological change. We use the household sector as a case study. Our analysis focuses on decision frameworks for technology choice, type of evaluation being carried out, treatment of market and behavioural failures, evaluated policy instruments, and key determinants used to mimic policy instruments. Although the review confirms criticism related to energy-economy models (e.g. unrealistic representation of decision-making by consumers when choosing technologies), they provide valuable guidance for policy evaluation related to energy efficiency. Different areas to further advance models remain open, particularly related to modelling issues, techno-economic and environmental aspects, behavioural determinants, and policy considerations.

  15. Design, synthesis, antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives

    Institute of Scientific and Technical Information of China (English)

    Hai-hong LI; Jian DING; Hua-liang JIANG; Xiu-hua ZHANG; Jin-zhi TAN; Li-li CHEN; Hong LIU; Xiao-min LUO; Xu SHEN; Li-ping LIN; Kai-xian CHEN

    2007-01-01

    Aim: To design and synthesize a novel class of antitumor agents, featuring the 3,5-substituted indolin-2-one framework. Methods: Based on enzyme binding fea-tures of (Z)-SU5402, introducing a β-pyrrole group at the 3-position of the indolin-2-one core, a series of novel 3,5-substituted indolin-2-ones were designed and synthesized. Four human Carcinoma cell lines of A-431, A-549, MDA-MB-468,and Autosomal Dominant Polycystic Kidney disease were chosen for the cell proliferation assay. Results: Twenty new compounds (la-t) with E configuration have been designed, synthesized and bioassayed. Their structural features were determined by nuclear magnetic resonance (NMR) spectra, low- and high-resolu-tion mass spectra, and confirmed by X-ray crystallography. Although the enzyme assay showed a weak inhibition effect against the epidermal growth factor receptor, vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet-derived growth factor receptor tyrosine kinases, the cell-based antitumor activity was promising. Compounds 1g and 1h showed higher inhibitory activity toward the A-549 and MDA-MB-468 cell lines with IC50 of 0.065-9.4 μmol/L. Conclusion: This study provides a new template for further development of potent antitumor drugs.

  16. COMPARATIVE ACCURACY EVALUATION OF FINE-SCALE GLOBAL AND LOCAL DIGITAL SURFACE MODELS: THE TSHWANE CASE STUDY I

    Directory of Open Access Journals (Sweden)

    A. Breytenbach

    2016-10-01

    Full Text Available Conducted in the City of Tshwane, South Africa, this study set about to test the accuracy of DSMs derived from different remotely sensed data locally. VHR digital mapping camera stereo-pairs, tri-stereo imagery collected by a Pléiades satellite and data detected from the Tandem-X InSAR satellite configuration were fundamental in the construction of seamless DSM products at different postings, namely 2 m, 4 m and 12 m. The three DSMs were sampled against independent control points originating from validated airborne LiDAR data. The reference surfaces were derived from the same dense point cloud at grid resolutions corresponding to those of the samples. The absolute and relative positional accuracies were computed using well-known DEM error metrics and accuracy statistics. Overall vertical accuracies were also assessed and compared across seven slope classes and nine primary land cover classes. Although all three DSMs displayed significantly more vertical errors where solid waterbodies, dense natural and/or alien woody vegetation and, in a lesser degree, urban residential areas with significant canopy cover were encountered, all three surpassed their expected positional accuracies overall.

  17. Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study.

    Science.gov (United States)

    El-Sayed, Sherihan; Metwally, Kamel; El-Shanawani, Abdalla A; Abdel-Aziz, Lobna M; El-Rashedy, Ahmed A; Soliman, Mahmoud E S; Quattrini, Luca; Coviello, Vito; la Motta, Concettina

    2017-10-15

    A series of quinazolinone-based rhodanine-3-acetic acids was synthesized and tested for in vitro aldose reductase inhibitory activity. All the target compounds displayed nanomolar activity against the target enzyme. Compounds 3a, 3b, and 3e exhibited almost 3-fold higher activity as compared to the only marketed reference drug epalrestat. Structure-activity relationship studies indicated that bulky substituents at the 3-phenyl ring of the quinazolinone moiety are generally not tolerated in the active site of the enzyme. Insertion of a methoxy group on the central benzylidene ring was found to have a variable effect on ALR-2 activity depending on the nature of peripheral quinazolinone ring substituents. Removal of the acetic acid moiety led to inactive or weakly active target compounds. Docking and molecular dynamic simulations of the most active rhodanine-3-acetic acid derivatives were also carried out, to provide the basis for further structure-guided design of novel inhibitors. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Comparative Accuracy Evaluation of Fine-Scale Global and Local Digital Surface Models: The Tshwane Case Study I

    Science.gov (United States)

    Breytenbach, A.

    2016-10-01

    Conducted in the City of Tshwane, South Africa, this study set about to test the accuracy of DSMs derived from different remotely sensed data locally. VHR digital mapping camera stereo-pairs, tri-stereo imagery collected by a Pléiades satellite and data detected from the Tandem-X InSAR satellite configuration were fundamental in the construction of seamless DSM products at different postings, namely 2 m, 4 m and 12 m. The three DSMs were sampled against independent control points originating from validated airborne LiDAR data. The reference surfaces were derived from the same dense point cloud at grid resolutions corresponding to those of the samples. The absolute and relative positional accuracies were computed using well-known DEM error metrics and accuracy statistics. Overall vertical accuracies were also assessed and compared across seven slope classes and nine primary land cover classes. Although all three DSMs displayed significantly more vertical errors where solid waterbodies, dense natural and/or alien woody vegetation and, in a lesser degree, urban residential areas with significant canopy cover were encountered, all three surpassed their expected positional accuracies overall.

  19. Teachers' Development Model to Authentic Assessment by Empowerment Evaluation Approach

    Science.gov (United States)

    Charoenchai, Charin; Phuseeorn, Songsak; Phengsawat, Waro

    2015-01-01

    The purposes of this study were 1) Study teachers authentic assessment, teachers comprehension of authentic assessment and teachers needs for authentic assessment development. 2) To create teachers development model. 3) Experiment of teachers development model. 4) Evaluate effectiveness of teachers development model. The research is divided into 4…

  20. Evaluation of animal models of neurobehavioral disorders

    Directory of Open Access Journals (Sweden)

    Nordquist Rebecca E

    2009-02-01

    Full Text Available Abstract Animal models play a central role in all areas of biomedical research. The process of animal model building, development and evaluation has rarely been addressed systematically, despite the long history of using animal models in the investigation of neuropsychiatric disorders and behavioral dysfunctions. An iterative, multi-stage trajectory for developing animal models and assessing their quality is proposed. The process starts with defining the purpose(s of the model, preferentially based on hypotheses about brain-behavior relationships. Then, the model is developed and tested. The evaluation of the model takes scientific and ethical criteria into consideration. Model development requires a multidisciplinary approach. Preclinical and clinical experts should establish a set of scientific criteria, which a model must meet. The scientific evaluation consists of assessing the replicability/reliability, predictive, construct and external validity/generalizability, and relevance of the model. We emphasize the role of (systematic and extended replications in the course of the validation process. One may apply a multiple-tiered 'replication battery' to estimate the reliability/replicability, validity, and generalizability of result. Compromised welfare is inherent in many deficiency models in animals. Unfortunately, 'animal welfare' is a vaguely defined concept, making it difficult to establish exact evaluation criteria. Weighing the animal's welfare and considerations as to whether action is indicated to reduce the discomfort must accompany the scientific evaluation at any stage of the model building and evaluation process. Animal model building should be discontinued if the model does not meet the preset scientific criteria, or when animal welfare is severely compromised. The application of the evaluation procedure is exemplified using the rat with neonatal hippocampal lesion as a proposed model of schizophrenia. In a manner congruent to

  1. Stretch-induced nerve injury: a proposed technique for the study of nerve regeneration and evaluation of the influence of gabapentin on this model

    Directory of Open Access Journals (Sweden)

    J.A. Machado

    2013-11-01

    Full Text Available The rat models currently employed for studies of nerve regeneration present distinct disadvantages. We propose a new technique of stretch-induced nerve injury, used here to evaluate the influence of gabapentin (GBP on nerve regeneration. Male Wistar rats (300 g; n=36 underwent surgery and exposure of the median nerve in the right forelimbs, either with or without nerve injury. The technique was performed using distal and proximal clamps separated by a distance of 2 cm and a sliding distance of 3 mm. The nerve was compressed and stretched for 5 s until the bands of Fontana disappeared. The animals were evaluated in relation to functional, biochemical and histological parameters. Stretching of the median nerve led to complete loss of motor function up to 12 days after the lesion (P<0.001, compared to non-injured nerves, as assessed in the grasping test. Grasping force in the nerve-injured animals did not return to control values up to 30 days after surgery (P<0.05. Nerve injury also caused an increase in the time of sensory recovery, as well as in the electrical and mechanical stimulation tests. Treatment of the animals with GBP promoted an improvement in the morphometric analysis of median nerve cross-sections compared with the operated vehicle group, as observed in the area of myelinated fibers or connective tissue (P<0.001, in the density of myelinated fibers/mm2 (P<0.05 and in the degeneration fragments (P<0.01. Stretch-induced nerve injury seems to be a simple and relevant model for evaluating nerve regeneration.

  2. Study on the effect of porous fence on air quality and traffic noise level around a double-decked road structure. Evaluation by numerical model.

    Science.gov (United States)

    Tokairin, Takayuki; Kitada, Toshihiro

    2005-06-01

    Fence for traffic noise control sometimes causes adverse effect on air pollution. Thus in this study, performance of porous fence as a tool for control of both air pollution and noise pollution was evaluated. A two-dimensional numerical model for flow and pollutant concentration and an analytical model for traffic noise were utilized in the analysis of a double-decked road structure with fences only at ground (Case 1) and at both ground and upper deck (Case 2). Porous fences were assumed only at the ground level since the solid fences at the upper deck usually leads to desirable result on air pollution. Effects of the variable porosity on air quality and noise level near road were evaluated. Obtained results showed: (1) flow pattern in leeward of fence was drastically changed at 40-50% porosity in Case 1 and 50% in Case 2. The porosity larger than 40% excluded presence of a circulation behind the fence. (2) Effect of porous fence on air pollution was different in Cases 1 and 2. In Case 1, the porous fence generally resulted in the reduction of air pollution at the ground level; on the other hand, in Case 2, it rather led to increase of the concentration. (3) Traffic noise level was also largely changed by the porosity of the fence; an example of simultaneous evaluation of the effects of porous fence on both air and noise pollution in Case 1 showed that the fence of 60% porosity leads to reduction of air pollution by 20% compared with solid fence case, and reduction of noise pollution by 4-6% in dB compared with no fence case, at 1 m high and 10 m from the road.

  3. Integrating species distributional, conservation planning, and individual based population models: A case study in critical habitat evaluation for the Northern Spotted Owl

    Science.gov (United States)

    Background / Question / Methods As part of the ongoing northern spotted owl recovery planning effort, we evaluated a series of alternative potential critical habitat scenarios using a species-distribution model (MaxEnt), a conservation-planning model (Zonation), and an individua...

  4. Model Performance Evaluation and Scenario Analysis (MPESA) Tutorial

    Science.gov (United States)

    This tool consists of two parts: model performance evaluation and scenario analysis (MPESA). The model performance evaluation consists of two components: model performance evaluation metrics and model diagnostics. These metrics provides modelers with statistical goodness-of-fit m...

  5. Sperm Oxidative Stress Is Detrimental to Embryo Development: A Dose-Dependent Study Model and a New and More Sensitive Oxidative Status Evaluation

    Directory of Open Access Journals (Sweden)

    Letícia S. de Castro

    2016-01-01

    Full Text Available Our study aimed to assess the impact of sperm oxidative stress on embryo development by means of a dose-dependent model. In experiment 1, straws from five bulls were subjected to incubation with increasing H2O2 doses (0, 12.5, 25, and 50 μM. Motility parameters were evaluated by Computed Assisted System Analysis (CASA. Experiment 2 was designed to study a high (50 μM and low dose (12.5 μM of H2O2 compared to a control (0 μM. Samples were incubated and further used for in vitro fertilization. Analyses of motility (CASA, oxidative status (CellROX green and 2’-7’ dichlorofluorescein diacetate, mitochondrial potential (JC-1, chromatin integrity (AO, and sperm capacitation status (chlortetracycline were performed. Embryos were evaluated based on fast cleavage (30 h.p.i., cleavage (D=3, development (D=5, and blastocyst rates (D=8. We observed a dose-dependent deleterious effect of H2O2 on motility and increase on the percentages of positive cells for CellROX green, capacitated sperm, and AO. A decrease on cleavage and blastocyst rates was observed as H2O2 increased. Also, we detected a blockage on embryo development. We concluded that sperm when exposed to oxidative environment presents impaired motility traits, prooxidative status, and premature capacitation; such alterations resulting in embryo development fail.

  6. Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.

    Science.gov (United States)

    Sarigol, Deniz; Uzgoren-Baran, Ayse; Tel, Banu Cahide; Somuncuoglu, Elif Inci; Kazkayasi, Inci; Ozadali-Sari, Keriman; Unsal-Tan, Oya; Okay, Gurol; Ertan, Mevlut; Tozkoparan, Birsen

    2015-05-15

    3-Substituted-1,2,4-triazole-5-thiones are versatile synthetic intermediates for the preparation of several biologically active N-bridged heterocyclic compounds, given that they have two reactive sites, thiocarbonyl and an amine nitrogen (N1/N4). For several years, our interest has focused on the synthesis of novel heterocyclic systems derived from 3-substituted-1,2,4-triazole-5-thiones having analgesic/anti-inflammatory activity. In this study, a series of novel thiazolo[3,2-b]-1,2,4-triazole-6(5H)-one derivatives bearing naproxen was synthesized and evaluated for their in vivo analgesic and anti-inflammatory properties in acute experimental pain and inflammation models. The compounds were also tested for their ulcerogenic potential. Our findings showed that all the newly synthesized derivatives attenuate nociception and inflammation compared with a control. All the synthesized compounds exhibited much lower ulcerogenic risk than the standard drugs indomethacin and naproxen. Some compounds with significant analgesic and/or anti-inflammatory activities as well as low ulcer scores were further evaluated for in vitro COX-1 and COX-2 inhibitory potential in a COX-catalyzed prostaglandin biosynthesis assay. Among the tested compounds, compound 1q showed the highest selectivity index (SI) of 4.87. The binding mode for some of the tested compounds to the cyclooxygenase (COX) enzymes was predicted using docking studies.

  7. Evaluation of the HSE COSHH Essentials exposure predictive model on the basis of BAuA field studies and existing substances exposure data.

    Science.gov (United States)

    Tischer, M; Bredendiek-Kämper, S; Poppek, U

    2003-10-01

    This paper presents an in-house BAuA study on the evaluation of the COSHH Essentials exposure predictive model. External validation is based on measurement data obtained in BAuA field studies performed in various industries, e.g. printing industry and textile industry. In addition, measurement data and information on industrial hygiene provided by the chemical industry within the framework of the Existing Substances Risk Assessment programme are used. Although the evaluated exposure data cover a wide variety of activities and workplace scenarios, there is still a considerable lack of appropriate exposure data, especially for the more stringent control strategies. It was found that the level of agreement between the measurements for solid substances (powders, dusts) and the predicted ranges is reasonably good. The situation is in part different for liquids. In workplaces where organic solvents are used in litre quantities, exposure levels are within the predicted ranges or are often lower. For small-scale uses of liquids (millilitre scale), e.g. in carpenters' workshops, there were indications that the exposure levels can exceed the predicted ranges. However, it must be noted that the database is rather small.

  8. Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates.

    Science.gov (United States)

    El-Messery, Shahenda M; Hassan, Ghada S; Nagi, Mahmoud N; Habib, El-Sayed E; Al-Rashood, Sarah T; El-Subbagh, Hussein I

    2016-10-01

    A new series of 2,3,6-substituted-quinazolin-4-ones was designed, synthesized, and evaluated for their in vitro DHFR inhibition, antimicrobial, and antitumor activities. Compounds 28 and 61 proved to be active DHFR inhibitors with IC50 0.02 and 0.01μM, respectively. Molecular modeling studies concluded that recognition with the key amino acid Phe34 is essential for binding and hence DHFR inhibition. Compounds 34, 56 and 66 showed broad spectrum antimicrobial activity comparable to Gentamicin and Ciprofloxacin. Compounds 40 and 64 showed broad spectrum antitumor activity toward several tumor cell lines and proved to be 10 fold more active than 5-FU, with GI50 MG-MID values of 2.2 and 2.4μM, respectively.

  9. Two criteria for evaluating risk prediction models.

    Science.gov (United States)

    Pfeiffer, R M; Gail, M H

    2011-09-01

    We propose and study two criteria to assess the usefulness of models that predict risk of disease incidence for screening and prevention, or the usefulness of prognostic models for management following disease diagnosis. The first criterion, the proportion of cases followed PCF (q), is the proportion of individuals who will develop disease who are included in the proportion q of individuals in the population at highest risk. The second criterion is the proportion needed to follow-up, PNF (p), namely the proportion of the general population at highest risk that one needs to follow in order that a proportion p of those destined to become cases will be followed. PCF (q) assesses the effectiveness of a program that follows 100q% of the population at highest risk. PNF (p) assess the feasibility of covering 100p% of cases by indicating how much of the population at highest risk must be followed. We show the relationship of those two criteria to the Lorenz curve and its inverse, and present distribution theory for estimates of PCF and PNF. We develop new methods, based on influence functions, for inference for a single risk model, and also for comparing the PCFs and PNFs of two risk models, both of which were evaluated in the same validation data.

  10. Quality Evaluation Model for Map Labeling

    Institute of Scientific and Technical Information of China (English)

    FAN Hong; ZHANG Zuxun; DU Daosheng

    2005-01-01

    This paper discusses and sums up the basic criterions of guaranteeing the labeling quality and abstracts the four basic factors including the conflict for a label with a label, overlay for label with the features, position's priority and the association for a label with its feature. By establishing the scoring system, a formalized four-factors quality evaluation model is constructed. Last, this paper introduces the experimental result of the quality evaluation model applied to the automatic map labeling system-MapLabel.

  11. The Information Service Evaluation (ISE Model

    Directory of Open Access Journals (Sweden)

    Laura Schumann

    2014-06-01

    Full Text Available Information services are an inherent part of our everyday life. Especially since ubiquitous cities are being developed all over the world their number is increasing even faster. They aim at facilitating the production of information and the access to the needed information and are supposed to make life easier. Until today many different evaluation models (among others, TAM, TAM 2, TAM 3, UTAUT and MATH have been developed to measure the quality and acceptance of these services. Still, they only consider subareas of the whole concept that represents an information service. As a holistic and comprehensive approach, the ISE Model studies five dimensions that influence adoption, use, impact and diffusion of the information service: information service quality, information user, information acceptance, information environment and time. All these aspects have a great impact on the final grading and of the success (or failure of the service. Our model combines approaches, which study subjective impressions of users (e.g., the perceived service quality, and user-independent, more objective approaches (e.g., the degree of gamification of a system. Furthermore, we adopt results of network economics, especially the "Success breeds success"-principle.

  12. Metrics for Evaluation of Student Models

    Science.gov (United States)

    Pelanek, Radek

    2015-01-01

    Researchers use many different metrics for evaluation of performance of student models. The aim of this paper is to provide an overview of commonly used metrics, to discuss properties, advantages, and disadvantages of different metrics, to summarize current practice in educational data mining, and to provide guidance for evaluation of student…

  13. 工程项目群的AHP-NET风险评价模型%Study on AHP-NET Risk Evaluation Model of Construction Programme

    Institute of Scientific and Technical Information of China (English)

    江新; 赵静

    2012-01-01

    In order to cope effectively with the risks involved with a construction programme, modeling of risk evaluation was studied based on the analysis of risk propagation. Firstly, the reason and result that risks were spreaded among the projects were analyzed. Then, on the assumption that risks were independent of each other, and based on the risk net formed due to risk propagation, an AHP-NET risk evaluation model was built by application of AHP, quantitative calculation of the maximum loss of risk in the risk net and the consideration of the manager' s risk preferences. Finally, the validity of the risk evaluation model was verified using a certain construction programme as an example. The result shows that the risk involved with the construction programme is relatively high and the projects needed to be focused in risk control were found.%在分析工程项目群风险传播的基础上,研究工程项目群风险评价建模问题.首先,分析工程项目群风险在各项目之间的传播原因及传播结果.然后,在假设各个风险相互独立的条件下,基于风险传播形成的工程项目群风险网络,应用层次分析法(AHP),定量计算风险网络中的最大风险损失,并考虑管理者的风险偏好,建立AHP-NET风险评价模型.最后,用某一工程项目群作为算例验证了该风险评价模型的可行性.算例结果表明,该工程项目群的风险较高,并且找到了该例项目群中应被重点关注的项目.

  14. SAPHIRE models and software for ASP evaluations

    Energy Technology Data Exchange (ETDEWEB)

    Sattison, M.B.; Schroeder, J.A.; Russell, K.D. [Idaho National Engineering Lab., Idaho Falls, ID (United States)] [and others

    1995-04-01

    The Idaho National Engineering Laboratory (INEL) over the past year has created 75 plant-specific Accident Sequence Precursor (ASP) models using the SAPHIRE suite of PRA codes. Along with the new models, the INEL has also developed a new module for SAPHIRE which is tailored specifically to the unique needs of conditional core damage probability (CCDP) evaluations. These models and software will be the next generation of risk tools for the evaluation of accident precursors by both NRR and AEOD. This paper presents an overview of the models and software. Key characteristics include: (1) classification of the plant models according to plant response with a unique set of event trees for each plant class, (2) plant-specific fault trees using supercomponents, (3) generation and retention of all system and sequence cutsets, (4) full flexibility in modifying logic, regenerating cutsets, and requantifying results, and (5) user interface for streamlined evaluation of ASP events.

  15. Performance Evaluation of FAO Model for Prediction of Yield Production, Soil Water and Solute Balance under Environmental Stresses (Case Study Winter Wheat

    Directory of Open Access Journals (Sweden)

    V. Rezaverdinejad

    2014-11-01

    Full Text Available In this study, the FAO agro-hydrological model was investigated and evaluated to predict of yield production, soil water and solute balance by winter wheat field data under water and salt stresses. For this purpose, a field experimental was conducted with three salinity levels of irrigation water include: S1, S2 and S3 corresponding to 1.4, 4.5 and 9.6 dS/m, respectively, and four irrigation depth levels include: I1, I2, I3 and I4 corresponding to 50, 75, 100 and 125% of crop water requirement, respectively, for two varieties of winter wheat: Roshan and Ghods, with three replications in an experimental farm of Birjand University for 1384-85 period. Based on results, the mean relative error of the model in yield prediction for Roshan and Ghods were obtained 9.2 and 26.1%, respectively. The maximum error of yield prediction in both of the Roshan and Ghods varieties, were obtained for S1I1, S2I1 and S3I1 treatments. The relative error of Roshan yield prediction for S1I1, S2I1 and S3I1 were calculated 20.0, 28.1 and 26.6%, respectively and for Ghods variety were calculated 61, 94.5 and 99.9%, respectively, that indicated a significant over estimate error under higher water stress. The mean relative error of model for all treatments, in prediction of soil water depletion and electrical conductivity of soil saturation extract, were calculated 7.1 and 5.8%, respectively, that indicated proper accuracy of model in prediction of soil water content and soil salinity.

  16. Numerical models for the evaluation of geothermal systems

    Energy Technology Data Exchange (ETDEWEB)

    Bodvarsson, G.S.; Pruess, K.; Lippmann, M.J.

    1986-08-01

    We have carried out detailed simulations of various fields in the USA (Bada, New Mexico; Heber, California); Mexico (Cerro Prieto); Iceland (Krafla); and Kenya (Olkaria). These simulation studies have illustrated the usefulness of numerical models for the overall evaluation of geothermal systems. The methodology for modeling the behavior of geothermal systems, different approaches to geothermal reservoir modeling and how they can be applied in comprehensive evaluation work are discussed.

  17. Evaluation Case Studies and Intercomparison with Regional Climate Model Simulations based on the DUE PERMAFROST Circumpolar Remote Sensing Service for Permafrost

    Science.gov (United States)

    Heim, Birgit; Bartsch, Annett; Elger, Kirsten; Rinke, Annette; Matthes, Heidrun; Zhou, Xu; Klehmet, Katharina; Buchhorn, Marcel; Duguay, Claude

    2014-05-01

    Permafrost is a subsurface phenomenon. However, monitoring from Earth Observation (EO) platforms can provide spatio-temporal data sets on permafrost-related indicators and geophysical parameters used in modelling and monitoring. The ESA Data User Element (DUE) Permafrost project (2009-2012) developed a suite of EO satellite-derived products: Land Surface Temperature (LST), Surface Soil Moisture (SSM), Surface Frozen and Thawed State (Freeze/Thaw), Terrain, Land Cover, and Surface Water. The satellite-derived products are weekly and monthly averages of the bio- and geophysical terrestrial parameters and static circum-Arctic maps. The final DUE Permafrost products cover the years 2007 to 2011 with a circum-Arctic coverage (north of 50°N). The products were released in 2012, and updated in 2013. Further information is available at geo.tuwien.ac.at/permafrost/. The remote sensing service also supports the EU-FP7 funded project PAGE21 - Changing Permafrost in the Arctic and its Global Effects in the 21st Century (www.page21.eu). The Global Terrestrial Network for Permafrost (GTN-P), initiated by the International Permafrost Association (IPA), is the prime program concerned with monitoring of permafrost. It provides an important database for the evaluation of EO-derived products and climate and permafrost models. GTN-P ground data ranges from air-, ground-, and borehole temperature data to active layer monitoring, soil moisture measurements, and the description of landform and vegetation. The involvement of scientific stakeholders and the IPA, and the ongoing evaluation of the satellite-derived products make the DUE Permafrost products relevant to the scientific community. The Helmholtz Climate Initiative REKLIM (Regionale KlimaAnderungen/Regional Climate Change) is a climate research program where regional observations and process studies are coupled with model simulations (http://www.reklim.de/en/home/). ESA DUE Permafrost User workshops initiated the use of EO

  18. ESA Data User Element DUE PERMAFROST Circumpolar Remote Sensing Service for Permafrost - Evaluation Case Studies and Intercomparison with Regional Climate Model Simulations

    Science.gov (United States)

    Heim, Birgit; Bartsch, Annett; Elger, Kirsten; Rinke, Annette; Matthes, Heidrun; Zhou, Xu; Klehmet, Katharina; Rockel, Burkhardt; Lantuit, Hugues; Duguay, Claude

    2015-04-01

    Permafrost is a subsurface phenomenon. However, monitoring from Earth Observation (EO) platforms can provide spatio-temporal data sets on permafrost-related indicators and quantities used in modelling and monitoring. The ESA Data User Element (DUE) Permafrost project (2009-2012) developed a suite of EO satellite-derived products: Land Surface Temperature (LST), Surface Soil Moisture (SSM), Surface Frozen and Thawed State (Freeze/Thaw), Terrain, Land Cover, and Surface Water. The satellite-derived products are weekly and monthly averages of the bio- and geophysical terrestrial parameters and static circum-Arctic maps. The final DUE Permafrost products cover the years 2007 to 2011, some products up to 2013, with a circum-Arctic coverage (north of 50°N). The products were released in 2012, and updated in 2013 and 2014. Further information is available at geo.tuwien.ac.at/permafrost/. The remote sensing service also supports the EU-FP7 funded project PAGE21 - Changing Permafrost in the Arctic and its Global Effects in the 21st Century (www.page21.eu). The Global Terrestrial Network for Permafrost (GTN-P), initiated by the International Permafrost Association (IPA), is the prime program concerned with monitoring of permafrost. It provides an important database for the evaluation of EO-derived products and climate and permafrost models. GTN-P ground data ranges from air-, ground-, and borehole temperature data to active layer monitoring, soil moisture measurements, and the description of landform and vegetation. The involvement of scientific stakeholders and the IPA, and the ongoing evaluation of the satellite-derived products make the DUE Permafrost products relevant to the scientific community. The Helmholtz Climate Initiative REKLIM (Regionale KlimaAnderungen/Regional Climate Change) is a climate research program where regional observations and process studies are coupled with model simulations (http://www.reklim.de/en/home/). ESA DUE Permafrost User workshops

  19. Recommendations concerning energy information model documentation, public access, and evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Wood, D.O.; Mason, M.J.

    1979-10-01

    A review is presented of the Energy Information Administration (EIA) response to Congressional and management concerns, relating specifically to energy information system documentation, public access to EIA systems, and scientific/peer evaluation. The relevant organizational and policy responses of EIA are discussed. An analysis of the model development process and approaches to, and organization of, model evaluation is presented. Included is a survey of model evaluation studies. A more detailed analysis of the origins of the legislated documentation and public access requirements is presented in Appendix A, and the results of an informal survey of other agency approaches to public access and evaluation is presented in Appendix B. Appendix C provides a survey of non-EIA activities relating to model documentation and evaluation. Twelve recommendations to improve EIA's procedures for energy information system documentation, evaluation activities, and public access are determined. These are discussed in detail. (MCW)

  20. Evaluating the urate-lowering effects of different microbial fermented extracts in hyperuricemic models accompanied with a safety study

    Directory of Open Access Journals (Sweden)

    Rong-Jane Chen

    2017-07-01

    Full Text Available Uric acid (UA is an end product of purine metabolism by the enzyme xanthine oxidase (XOD. Hyperuricemia is characterized by the accumulation of serum UA and is an important risk factor for gout and many chronic disorders. XOD inhibitors or uricase (catalyzes UA to the more soluble end product can prevent these chronic diseases. However, currently available hypouricemic agents induce severe side effects. Therefore, we developed new microbial fermented extracts (MFEs with substantial XOD inhibition activity from Lactobacillus (MFE-21 and Acetobacter (MFE-25, and MFE-120 with high uricase activity from Aspergillus. The urate-lowering effects and safety of these MFEs were evaluated. Our results showed that MFE-25 exerts superior urate-lowering effects in the therapeutic model. In the preventive model, both MFE-120 and MFE-25 significantly reduced UA. The results of the safety study showed that no organ toxicity and no treatment-related adverse effects were observed in mice treated with high doses of MFEs. Taken together, the results showed the effectiveness of MFEs in reducing hyperuricemia without systemic toxicity in mice at high doses, suggesting that they are safe for use in the treatment and prevention of hyperuricemia.

  1. Statistical modeling for visualization evaluation through data fusion.

    Science.gov (United States)

    Chen, Xiaoyu; Jin, Ran

    2017-11-01

    There is a high demand of data visualization providing insights to users in various applications. However, a consistent, online visualization evaluation method to quantify mental workload or user preference is lacking, which leads to an inefficient visualization and user interface design process. Recently, the advancement of interactive and sensing technologies makes the electroencephalogram (EEG) signals, eye movements as well as visualization logs available in user-centered evaluation. This paper proposes a data fusion model and the application procedure for quantitative and online visualization evaluation. 15 participants joined the study based on three different visualization designs. The results provide a regularized regression model which can accurately predict the user's evaluation of task complexity, and indicate the significance of all three types of sensing data sets for visualization evaluation. This model can be widely applied to data visualization evaluation, and other user-centered designs evaluation and data analysis in human factors and ergonomics. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Analysis and evaluation of collaborative modeling processes

    NARCIS (Netherlands)

    Ssebuggwawo, D.

    2012-01-01

    Analysis and evaluation of collaborative modeling processes is confronted with many challenges. On the one hand, many systems design and re-engineering projects require collaborative modeling approaches that can enhance their productivity. But, such collaborative efforts, which often consist of the

  3. A method to evaluate response models

    NARCIS (Netherlands)

    Bruijnes, Merijn; Wapperom, Sjoerd; op den Akker, Hendrikus J.A.; Heylen, Dirk K.J.; Bickmore, Timothy; Marcella, Stacy; Sidner, Candace

    We are working towards computational models of mind of virtual characters that act as suspects in interview (interrogation) training of police officers. We implemented a model that calculates the responses of the virtual suspect based on theory and observation. We evaluated it by means of our test,

  4. Museum: Multidimensional web page segment evaluation model

    CERN Document Server

    Kuppusamy, K S

    2012-01-01

    The evaluation of a web page with respect to a query is a vital task in the web information retrieval domain. This paper proposes the evaluation of a web page as a bottom-up process from the segment level to the page level. A model for evaluating the relevancy is proposed incorporating six different dimensions. An algorithm for evaluating the segments of a web page, using the above mentioned six dimensions is proposed. The benefits of fine-granining the evaluation process to the segment level instead of the page level are explored. The proposed model can be incorporated for various tasks like web page personalization, result re-ranking, mobile device page rendering etc.

  5. Evaluation of the Xpa-Deficient Transgenic Mouse Model for Short-Term Carcinogenicity Testing: 9-Month Studies with Haloperidol, Reserpine, Phenacetin, and D-Mannitol

    NARCIS (Netherlands)

    Lina, B.A.R.; Woutersen, R.A.; Bruijntjes, J.P.; Benthem, J. van; Berg, J.A.H. van den; Monbaliu, J.; Thoolen, B.J.J.M.; Beems, R.B.; Kreijl, C.F. van

    2004-01-01

    As part of the international evaluation program coordinated by ILSI/HESI, the potential of DNA repair deficient Xpa-/- mice and the double knockout Xpa-/-.p53+/- mice for short term carcinogenicity assays was evaluated. For comparison also wild-type C57BL/6 mice (WT) were included in these studies.

  6. Development of a program model to evaluate the potential for reuse of single-use medical devices: results of a pilot test study.

    Science.gov (United States)

    Abreu, Eduardo L; Haire, Donna M; Malchesky, Paul S; Wolf-Bloom, David F; Cornhill, J Fredrick

    2002-01-01

    Single-use medical devices (SUDs, or disposables) have become a major expense in hospital budgets. The need for cost reduction and the availability of sterilization technologies other than the autoclave have prompted hospitals worldwide to begin reusing disposables, in many cases without proper assessment of the true costs (time, personnel, etc) and ease/difficulty of implementation of an institutional reuse program. Our group has developed a rigorous program model to evaluate SUDs for reuse. The program comprises 3 sequential protocols: (1) device audit, (2) laboratory evaluation, and (3) clinical evaluation. Use of this model can produce scientific and financial data sufficient for any institution interested in reuse to reach an initial decision about its feasibility. In addition to the testing outcomes, regulatory requirements, the position of manufacturers and third-party reprocessors, and legal and ethical concerns must be considered. A successful reuse program must include ongoing evaluations to ensure that the safety levels and cost savings established during the initial audit and evaluation phases continue. Herein, we give the rationale and details of our program model and discuss results of our pilot application of the "ideal" protocol in a real-world context.

  7. A COMPARISON OF SEMANTIC SIMILARITY MODELS IN EVALUATING CONCEPT SIMILARITY

    Directory of Open Access Journals (Sweden)

    Q. X. Xu

    2012-08-01

    Full Text Available The semantic similarities are important in concept definition, recognition, categorization, interpretation, and integration. Many semantic similarity models have been established to evaluate semantic similarities of objects or/and concepts. To find out the suitability and performance of different models in evaluating concept similarities, we make a comparison of four main types of models in this paper: the geometric model, the feature model, the network model, and the transformational model. Fundamental principles and main characteristics of these models are introduced and compared firstly. Land use and land cover concepts of NLCD92 are employed as examples in the case study. The results demonstrate that correlations between these models are very high for a possible reason that all these models are designed to simulate the similarity judgement of human mind.

  8. a Comparison of Semantic Similarity Models in Evaluating Concept Similarity

    Science.gov (United States)

    Xu, Q. X.; Shi, W. Z.

    2012-08-01

    The semantic similarities are important in concept definition, recognition, categorization, interpretation, and integration. Many semantic similarity models have been established to evaluate semantic similarities of objects or/and concepts. To find out the suitability and performance of different models in evaluating concept similarities, we make a comparison of four main types of models in this paper: the geometric model, the feature model, the network model, and the transformational model. Fundamental principles and main characteristics of these models are introduced and compared firstly. Land use and land cover concepts of NLCD92 are employed as examples in the case study. The results demonstrate that correlations between these models are very high for a possible reason that all these models are designed to simulate the similarity judgement of human mind.

  9. Selection and evaluation of reference genes for expression studies with quantitative PCR in the model fungus Neurospora crassa under different environmental conditions in continuous culture.

    Directory of Open Access Journals (Sweden)

    Kathleen D Cusick

    Full Text Available Neurospora crassa has served as a model organism for studying circadian pathways and more recently has gained attention in the biofuel industry due to its enhanced capacity for cellulase production. However, in order to optimize N. crassa for biotechnological applications, metabolic pathways during growth under different environmental conditions must be addressed. Reverse-transcription quantitative PCR (RT-qPCR is a technique that provides a high-throughput platform from which to measure the expression of a large set of genes over time. The selection of a suitable reference gene is critical for gene expression studies using relative quantification, as this strategy is based on normalization of target gene expression to a reference gene whose expression is stable under the experimental conditions. This study evaluated twelve candidate reference genes for use with N. crassa when grown in continuous culture bioreactors under different light and temperature conditions. Based on combined stability values from NormFinder and Best Keeper software packages, the following are the most appropriate reference genes under conditions of: (1 light/dark cycling: btl, asl, and vma1; (2 all-dark growth: btl, tbp, vma1, and vma2; (3 temperature flux: btl, vma1, act, and asl; (4 all conditions combined: vma1, vma2, tbp, and btl. Since N. crassa exists as different cell types (uni- or multi-nucleated, expression changes in a subset of the candidate genes was further assessed using absolute quantification. A strong negative correlation was found to exist between ratio and threshold cycle (CT values, demonstrating that CT changes serve as a reliable reflection of transcript, and not gene copy number, fluctuations. The results of this study identified genes that are appropriate for use as reference genes in RT-qPCR studies with N. crassa and demonstrated that even with the presence of different cell types, relative quantification is an acceptable method for measuring

  10. Selection and evaluation of reference genes for expression studies with quantitative PCR in the model fungus Neurospora crassa under different environmental conditions in continuous culture.

    Science.gov (United States)

    Cusick, Kathleen D; Fitzgerald, Lisa A; Pirlo, Russell K; Cockrell, Allison L; Petersen, Emily R; Biffinger, Justin C

    2014-01-01

    Neurospora crassa has served as a model organism for studying circadian pathways and more recently has gained attention in the biofuel industry due to its enhanced capacity for cellulase production. However, in order to optimize N. crassa for biotechnological applications, metabolic pathways during growth under different environmental conditions must be addressed. Reverse-transcription quantitative PCR (RT-qPCR) is a technique that provides a high-throughput platform from which to measure the expression of a large set of genes over time. The selection of a suitable reference gene is critical for gene expression studies using relative quantification, as this strategy is based on normalization of target gene expression to a reference gene whose expression is stable under the experimental conditions. This study evaluated twelve candidate reference genes for use with N. crassa when grown in continuous culture bioreactors under different light and temperature conditions. Based on combined stability values from NormFinder and Best Keeper software packages, the following are the most appropriate reference genes under conditions of: (1) light/dark cycling: btl, asl, and vma1; (2) all-dark growth: btl, tbp, vma1, and vma2; (3) temperature flux: btl, vma1, act, and asl; (4) all conditions combined: vma1, vma2, tbp, and btl. Since N. crassa exists as different cell types (uni- or multi-nucleated), expression changes in a subset of the candidate genes was further assessed using absolute quantification. A strong negative correlation was found to exist between ratio and threshold cycle (CT) values, demonstrating that CT changes serve as a reliable reflection of transcript, and not gene copy number, fluctuations. The results of this study identified genes that are appropriate for use as reference genes in RT-qPCR studies with N. crassa and demonstrated that even with the presence of different cell types, relative quantification is an acceptable method for measuring gene

  11. Modeling and testing maternal and newborn care mHealth interventions: a pilot impact evaluation and follow-up qualitative study in Guatemala.

    Science.gov (United States)

    Prieto, José Tomás; Zuleta, Clara; Rodríguez, Jorge Tulio

    2017-03-01

    To develop a descriptive model of structural characteristics of mHealth in the context of newborn nutrition, and to assess the effects of illustrative interventions through a mixed-methods study consisting of an impact evaluation and a qualitative assessment. We conducted a 23-week intervention with 100 mothers in rural Guatemala in 2013 and 2014. In group 1 ( n  = 24), participants received health-promoting text messages. In group 2 ( n  = 32), peer-to-peer groups were formed. In group 3 ( n  = 30), peer-to-peer groups were formed, a health professional participated in the discussions, and participants received health-promoting messages. In the control group ( n  = 14), participants were simply given a mobile phone. We measured changes in knowledge and self-reported behavior. Four focus groups in 2015 showed the perceptions of 44 additional women and the potential of the previously tested interventions in other marginalized areas. Significant relationships were found between group membership and changes in knowledge ( P  mHealth interventions can play an important role in helping to encourage recommended breastfeeding attitudes along with providing rich information about challenges in rural areas. A mixed-methods study was appropriate to compare the effects and assess the potential of mHealth strategies in a complex rural setting.

  12. Transcutaneous in vivo Raman spectroscopic studies in a mouse model: evaluation of changes in the breast associated with pregnancy and lactation

    Science.gov (United States)

    Bhattacharjee, Tanmoy; Maru, Girish; Ingle, Arvind; Krishna, C. Murali

    2013-04-01

    Raman spectroscopy (RS) has been extensively explored as an alternative diagnostic tool for breast cancer. This can be attributed to its sensitivity to malignancy-associated biochemical changes. However, biochemical changes due to nonmalignant conditions like benign lesions, inflammatory diseases, aging, menstrual cycle, pregnancy, and lactation may act as confounding factors in diagnosis of breast cancer. Therefore, in this study, the efficacy of RS to classify pregnancy and lactation-associated changes as well as its effect on breast tumor diagnosis was evaluated. Since such studies are difficult in human subjects, a mouse model was used. Spectra were recorded transcutaneously from the breast region of six Swiss bare mice postmating, during pregnancy, and during lactation. Data were analyzed using multivariate statistical tool Principal Component-Linear Discriminant Analysis. Results suggest that RS can differentiate breasts of pregnant/lactating mice from those of normal mice, the classification efficiencies being 100%, 60%, and 88% for normal, pregnant, and lactating mice, respectively. Frank breast tumors could be classified with 97.5% efficiency, suggesting that these physiological changes do not affect the ability of RS to detect breast tumors.

  13. Evaluation of a lake whitefish bioenergetics model

    Science.gov (United States)

    Madenjian, Charles P.; O'Connor, Daniel V.; Pothoven, Steven A.; Schneeberger, Philip J.; Rediske, Richard R.; O'Keefe, James P.; Bergstedt, Roger A.; Argyle, Ray L.; Brandt, Stephen B.

    2006-01-01

    We evaluated the Wisconsin bioenergetics model for lake whitefish Coregonus clupeaformis in the laboratory and in the field. For the laboratory evaluation, lake whitefish were fed rainbow smelt Osmerus mordax in four laboratory tanks during a 133-d experiment. Based on a comparison of bioenergetics model predictions of lake whitefish food consumption and growth with observed consumption and growth, we concluded that the bioenergetics model furnished significantly biased estimates of both food consumption and growth. On average, the model overestimated consumption by 61% and underestimated growth by 16%. The source of the bias was probably an overestimation of the respiration rate. We therefore adjusted the respiration component of the bioenergetics model to obtain a good fit of the model to the observed consumption and growth in our laboratory tanks. Based on the adjusted model, predictions of food consumption over the 133-d period fell within 5% of observed consumption in three of the four tanks and within 9% of observed consumption in the remaining tank. We used polychlorinated biphenyls (PCBs) as a tracer to evaluate model performance in the field. Based on our laboratory experiment, the efficiency with which lake whitefish retained PCBs from their food (I?) was estimated at 0.45. We applied the bioenergetics model to Lake Michigan lake whitefish and then used PCB determinations of both lake whitefish and their prey from Lake Michigan to estimate p in the field. Application of the original model to Lake Michigan lake whitefish yielded a field estimate of 0.28, implying that the original formulation of the model overestimated consumption in Lake Michigan by 61%. Application of the bioenergetics model with the adjusted respiration component resulted in a field I? estimate of 0.56, implying that this revised model underestimated consumption by 20%.

  14. Saphire models and software for ASP evaluations

    Energy Technology Data Exchange (ETDEWEB)

    Sattison, M.B. [Idaho National Engineering Lab., Idaho Falls, ID (United States)

    1997-02-01

    The Idaho National Engineering Laboratory (INEL) over the three years has created 75 plant-specific Accident Sequence Precursor (ASP) models using the SAPHIRE suite of PRA codes. Along with the new models, the INEL has also developed a new module for SAPHIRE which is tailored specifically to the unique needs of ASP evaluations. These models and software will be the next generation of risk tools for the evaluation of accident precursors by both the U.S. Nuclear Regulatory Commission`s (NRC`s) Office of Nuclear Reactor Regulation (NRR) and the Office for Analysis and Evaluation of Operational Data (AEOD). This paper presents an overview of the models and software. Key characteristics include: (1) classification of the plant models according to plant response with a unique set of event trees for each plant class, (2) plant-specific fault trees using supercomponents, (3) generation and retention of all system and sequence cutsets, (4) full flexibility in modifying logic, regenerating cutsets, and requantifying results, and (5) user interface for streamlined evaluation of ASP events. Future plans for the ASP models is also presented.

  15. A Comprehensive Model for Evaluating Coalbed Methane Reservoirs in China

    Institute of Scientific and Technical Information of China (English)

    YAO Yanbin; LIU Dameng; TANG Dazhen; HUANG Wenhui; TANG Shuheng; CHE Yao

    2008-01-01

    Coalbed methane reservoir (CBMR) evaluation is important for choosing the prospective target area for coalbed methane exploration and production. This study aims at identifying the characteristic parameters and methods to evaluate CBMR. Based on the geological surveys, laboratory measurements and field works, a four-level analytic hierarchy process (AHP) model for CBMR evaluation is proposed. In this model, different weights are prioritized and assigned on the basis of three main criteria (including reservoir physical property, storage capacity and geological characteristics), 15 sub-criteria, and 18 technical alternatives; the later of which are discussed in detail. The model was applied to evaluate the CBMR of the Permo-Carboniferous coals in the Qinshui Basin, North China. This GIS-based fuzzy AHP comprehensive model can be used for the evaluation of CBMR of medium-high rank (mean maximum vitrinite reflectance >0.5%) coal districts in China.

  16. Evaluation of trends in wheat yield models

    Science.gov (United States)

    Ferguson, M. C.

    1982-01-01

    Trend terms in models for wheat yield in the U.S. Great Plains for the years 1932 to 1976 are evaluated. The subset of meteorological variables yielding the largest adjusted R(2) is selected using the method of leaps and bounds. Latent root regression is used to eliminate multicollinearities, and generalized ridge regression is used to introduce bias to provide stability in the data matrix. The regression model used provides for two trends in each of two models: a dependent model in which the trend line is piece-wise continuous, and an independent model in which the trend line is discontinuous at the year of the slope change. It was found that the trend lines best describing the wheat yields consisted of combinations of increasing, decreasing, and constant trend: four combinations for the dependent model and seven for the independent model.

  17. CRITICAL ANALYSIS OF EVALUATION MODEL LOMCE

    Directory of Open Access Journals (Sweden)

    José Luis Bernal Agudo

    2015-06-01

    Full Text Available The evaluation model that the LOMCE projects sinks its roots into the neoliberal beliefs, reflecting a specific way of understanding the world. What matters is not the process but the results, being the evaluation the center of the education-learning processes. It presents an evil planning, since the theory that justifies the model doesn’t specify upon coherent proposals, where there is an excessive worry for excellence and diversity is left out. A comprehensive way of understanding education should be recovered.

  18. A model-based evaluation system of enterprise

    Institute of Scientific and Technical Information of China (English)

    Yan Junwei; Ye Yang; Wang Jian

    2005-01-01

    This paper analyses the architecture of enterprise modeling, proposesindicator selection principles and indicator decomposition methods, examines the approaches to the evaluation of enterprise modeling and designs an evaluation model of AHP. Then a model-based evaluation system of enterprise is presented toeffectively evaluate the business model in the framework of enterprise modeling.

  19. Information and complexity measures for hydrologic model evaluation

    Science.gov (United States)

    Hydrological models are commonly evaluated through the residual-based performance measures such as the root-mean square error or efficiency criteria. Such measures, however, do not evaluate the degree of similarity of patterns in simulated and measured time series. The objective of this study was to...

  20. Evaluating Interventions with Multimethod Data: A Structural Equation Modeling Approach

    Science.gov (United States)

    Crayen, Claudia; Geiser, Christian; Scheithauer, Herbert; Eid, Michael

    2011-01-01

    In many intervention and evaluation studies, outcome variables are assessed using a multimethod approach comparing multiple groups over time. In this article, we show how evaluation data obtained from a complex multitrait-multimethod-multioccasion-multigroup design can be analyzed with structural equation models. In particular, we show how the…

  1. Modeling Energy and Development : An Evaluation of Models and Concepts

    NARCIS (Netherlands)

    Ruijven, Bas van; Urban, Frauke; Benders, René M.J.; Moll, Henri C.; Sluijs, Jeroen P. van der; Vries, Bert de; Vuuren, Detlef P. van

    2008-01-01

    Most global energy models are developed by institutes from developed countries focusing primarily oil issues that are important in industrialized countries. Evaluation of the results for Asia of the IPCC/SRES models shows that broad concepts of energy and development. the energy ladder and the envir

  2. Triazole linked mono carbonyl curcumin-isatin bifunctional hybrids as novel anti tubulin agents: Design, synthesis, biological evaluation and molecular modeling studies.

    Science.gov (United States)

    Sharma, Sahil; Gupta, Manish K; Saxena, Ajit K; Bedi, Preet Mohinder S

    2015-11-15

    Keeping in view the limitations associated with currently available anticancer drugs, molecular hybrids of mono carbonyl curcumin and isatin tethered by triazole ring have been synthesized and evaluated for in vitro cytotoxicity against THP-1, COLO-205, HCT-116, A549, HeLa, CAKI-I, PC-3, MiaPaca-2 human cancer cell lines. The results revealed that the compounds SA-1 to SA-9, SB-2, SB-3, SB-4, SB-7 and SC-2 showed a good range of IC50 values against THP-1, COLO-205, HCT-116 and PC-3 cell lines, while the other four cell lines among these were found to be almost resistant. Structure activity relationship revealed that the nature of Ring X and substitution at position R influences the activity. Methoxy substituted phenyl ring as Ring X and H as R were found to be the ideal structural features. The most potent compounds (SA-2, SA-3, SA-4, SA-7) were further tested for tubulin inhibition. Compound SA-2 was found to significantly inhibit the tubulin polymerization (IC50=1.2 μM against HCT-116). Compound SA-2, moreover, lead to the disruption of microtubules as confirmed by immunofluorescence technique. The significant cytotoxicity and tubulin inhibition by SA-2 was streamlined by molecular modeling studies where it was docked at the curcumin binding site of tubulin.

  3. Effect of the ω-acylceramides on the lipid organization of stratum corneum model membranes evaluated by X-ray diffraction and FTIR studies (Part I).

    Science.gov (United States)

    de Sousa Neto, Diogenes; Gooris, Gert; Bouwstra, Joke

    2011-03-01

    The lipid organization in the outermost layer of the skin, the stratum corneum, is important for the skin barrier function. The stratum corneum lipids are composed of ceramides (CER), free fatty acids (FFA) and cholesterol (CHOL). In the present study Fourier transform infrared (FTIR) and small-angle X-ray scattering (SAXS) techniques were utilized to evaluate the effect of three C18 fatty acid esterified ω-acylceramides (CER EOS) on the lipid organization of stratum corneum model membranes. FTIR spectra (scissoring and rocking bands) showed as a function of temperature significant line-shape changes for both components assigned to the orthorhombic phase. Second-derivative analyzes revealed a significant decrease in the interchain coupling strength (Δν values) for the samples formed by CER EOS with the linoleate (CER EOS-L) and oleate (CER EOS-O) moiety around 28.5°C. However, only a gradual decrease in the Δν values was noticed for the mixture formed with CER EOS with the stearate moiety (CER EOS-S) over the whole temperature range. In the absence of CER EOS the decrease started already at 25.5°C, demonstrating that CER EOS stabilized the orthorhombic lattice. This stabilization was most pronounced for the CER EOS-S. Spectral fittings allowed to evaluate the orientation changes of the skeletal plane within the orthorhombic unit cell (θ values) for a given temperature range. From the best-fit parameters (peak area values), a decrease in the orthorhombic phase contribution to the scissoring band was also monitored as a function of the temperature. SAXS studies showed the coexistence of two lamellar phases with a periodicity of ∼5.5 nm (short periodicity phase, SPP) and ∼12 nm (LPP) in the presence of the CER EOS-L and CER EOS-O. However, no diffraction peaks associated to the LPP were detected for CER EOS-S. While CER EOS-S most efficiently stabilized the orthorhombic phase, CER EOS-L and CER EOS-O promoted the presence of the LPP. Therefore, the

  4. Study on Corporate Social Responsibility of Evaluation Model and Standard%企业社会责任评价模型及标准研究

    Institute of Scientific and Technical Information of China (English)

    蔡月祥

    2011-01-01

    分析了当前国外公司制定的生产守则、政府组织制定的社会责任评价体系、非政府组织或研究机构制定的社会责任评价体系等三类企业社会责任评价标准的优势和不足,以卡罗尔金字塔模型为基础,建立了比较科学的企业社会责任评价模型,并就如何实施企业社会责任的评价提出了若干建议.%This article analyzes strengths and weaknesses of evaluation standard of CSR that the current overseas business drafted codes of conduct, the government organizations and non-governmental organizations & research institutions formulated the evaluation system of CSR. Based on Carol pyramid model, author sets up a more scientific evaluation model of CSR and how to implement the evaluation of a number of recommendations.

  5. [Applying multilevel models in evaluation of bioequivalence (I)].

    Science.gov (United States)

    Liu, Qiao-lan; Shen, Zhuo-zhi; Chen, Feng; Li, Xiao-song; Yang, Min

    2009-12-01

    This study aims to explore the application value of multilevel models for bioequivalence evaluation. Using a real example of 2 x 4 cross-over experimental design in evaluating bioequivalence of antihypertensive drug, this paper explores complex variance components corresponding to criteria statistics in existing methods recommended by FDA but obtained in multilevel models analysis. Results are compared with those from FDA standard Method of Moments, specifically on the feasibility and applicability of multilevel models in directly assessing the bioequivalence (ABE), the population bioequivalence (PBE) and the individual bioequivalence (IBE). When measuring ln (AUC), results from all variance components of the test and reference groups such as total variance (sigma(TT)(2) and sigma(TR)(2)), between-subject variance (sigma(BT)(2) and sigma(BR)(2)) and within-subject variance (sigma(WT)(2) and sigma(WR)(2)) estimated by simple 2-level models are very close to those that using the FDA Method of Moments. In practice, bioequivalence evaluation can be carried out directly by multilevel models, or by FDA criteria, based on variance components estimated from multilevel models. Both approaches produce consistent results. Multilevel models can be used to evaluate bioequivalence in cross-over test design. Compared to FDA methods, this one is more flexible in decomposing total variance into sub components in order to evaluate the ABE, PBE and IBE. Multilevel model provides a new way into the practice of bioequivalence evaluation.

  6. Evaluating spatial patterns in hydrological modelling

    DEFF Research Database (Denmark)

    Koch, Julian

    of spatial information in a holistic assessment. Opposed, statistical measures typically only address a limited amount of spatial information. A web-based survey and a citizen science project are employed to quantify the collective perceptive skills of humans aiming at benchmarking spatial metrics...... of environmental science, such as meteorology, geostatistics or geography. In total, seven metrics are evaluated with respect to their capability to quantitatively compare spatial patterns. The human visual perception is often considered superior to computer based measures, because it integrates various dimensions...... with respect to their capability to mimic human evaluations. This PhD thesis aims at expanding the standard toolbox of spatial model evaluation with innovative metrics that adequately compare spatial patterns. Driven by the rise of more complex model structures and the increase of suitable remote sensing...

  7. Evaluation of help model replacement codes

    Energy Technology Data Exchange (ETDEWEB)

    Whiteside, Tad [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Hang, Thong [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Flach, Gregory [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2009-07-01

    This work evaluates the computer codes that are proposed to be used to predict percolation of water through the closure-cap and into the waste containment zone at the Department of Energy closure sites. This work compares the currently used water-balance code (HELP) with newly developed computer codes that use unsaturated flow (Richards’ equation). It provides a literature review of the HELP model and the proposed codes, which result in two recommended codes for further evaluation: HYDRUS-2D3D and VADOSE/W. This further evaluation involved performing actual simulations on a simple model and comparing the results of those simulations to those obtained with the HELP code and the field data. From the results of this work, we conclude that the new codes perform nearly the same, although moving forward, we recommend HYDRUS-2D3D.

  8. A comparative study evaluating the clinical efficacy of skin tapes versus silicone gel for the treatment of posttrauma scar in the rabbit model

    Directory of Open Access Journals (Sweden)

    Chih-Chien Wang

    2014-01-01

    Full Text Available Background: Skin tape and silicone gel are two common over-the-counter preparations used to enhance the cosmesis of keloids and hypertrophic scars of posttrauma wounds. This animal study was performed to determine the clinical efficacy of skin tape versus silicone gel in subjects with scars. Materials and Methods: Three New Zealand rabbits that received total 12 incision wounds which two incision wounds on one ear side and subsequent primary suturing were studied. Stitches were removed after 1 week. Silicone gel was applied right upper side of the rabbit′s ear directly on surgical incision wounds, and skin tapes were also applied left upper side of the rabbit′s ear directly on another surgical incision wounds after 1 week of surgery. The lower incisions in both ears were covered with sterilized gauze and served as controls. We compared two experimental groups at binaural with using Vancouver Scar Scale, Manchester Scar Scale, and The Stony Brook Scar Evaluation Scale. These are widely used in clinical practice and research to document change in scar appearance. Results: We describe a rabbit model for incisional wounds and scarring outcome measures. The results of scar measuring devices demonstrated that skin tape reduced scar formation as well as silicone gel. Conclusions: The results of cosmetic demonstrated that skin tape reduced scar formation as well as silicone gel. However, the economical and effective materials were the important subject that suffices for clinical requirement. The application of these scar prevention devices to reduce scar formation after surgical incision is worthy of future investigation. Moreover, skin tape may represent a low-cost alternative and low scar formation for closure of surgical incisions.

  9. An Evaluation of Unsaturated Flow Models in an Arid Climate

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, J. [Univ. of Nevada, Las Vegas, NV (United States)

    1999-12-01

    The objective of this study was to evaluate the effectiveness of two unsaturated flow models in arid regions. The area selected for the study was the Area 5 Radioactive Waste Management Site (RWMS) at the Nevada Test Site in Nye County, Nevada. The two models selected for this evaluation were HYDRUS-1D [Simunek et al., 1998] and the SHAW model [Flerchinger and Saxton, 1989]. Approximately 5 years of soil-water and atmospheric data collected from an instrumented weighing lysimeter site near the RWMS were used for building the models with actual initial and boundary conditions representative of the site. Physical processes affecting the site and model performance were explored. Model performance was based on a detailed sensitivity analysis and ultimately on storage comparisons. During the process of developing descriptive model input, procedures for converting hydraulic parameters for each model were explored. In addition, the compilation of atmospheric data collected at the site became a useful tool for developing predictive functions for future studies. The final model results were used to evaluate the capacities of the HYDRUS and SHAW models for predicting soil-moisture movement and variable surface phenomena for bare soil conditions in the arid vadose zone. The development of calibrated models along with the atmospheric and soil data collected at the site provide useful information for predicting future site performance at the RWMS.

  10. Evaluation of preformance of Predictive Models for Deoxynivalenol in Wheat

    NARCIS (Netherlands)

    Fels, van der H.J.

    2014-01-01

    The aim of this study was to evaluate the performance of two predictive models for deoxynivalenol contamination of wheat at harvest in the Netherlands, including the use of weather forecast data and external model validation. Data were collected in a different year and from different wheat fields th

  11. Outline and Preliminary Evaluation of the Classical Digital Library Model.

    Science.gov (United States)

    MacCall, Steven L.; Cleveland, Ana D.; Gibson, Ian E.

    1999-01-01

    Outlines the classical digital library model, which is derived from traditional practices of library and information science professionals, as an alternative to the database retrieval model. Reports preliminary results from an evaluation study of library and information professionals and endusers involved with primary care medicine. (AEF)

  12. Evaluation of preformance of Predictive Models for Deoxynivalenol in Wheat

    NARCIS (Netherlands)

    Fels, van der H.J.

    2014-01-01

    The aim of this study was to evaluate the performance of two predictive models for deoxynivalenol contamination of wheat at harvest in the Netherlands, including the use of weather forecast data and external model validation. Data were collected in a different year and from different wheat fields

  13. Evaluating the TD model of classical conditioning.

    Science.gov (United States)

    Ludvig, Elliot A; Sutton, Richard S; Kehoe, E James

    2012-09-01

    The temporal-difference (TD) algorithm from reinforcement learning provides a simple method for incrementally learning predictions of upcoming events. Applied to classical conditioning, TD models suppose that animals learn a real-time prediction of the unconditioned stimulus (US) on the basis of all available conditioned stimuli (CSs). In the TD model, similar to other error-correction models, learning is driven by prediction errors--the difference between the change in US prediction and the actual US. With the TD model, however, learning occurs continuously from moment to moment and is not artificially constrained to occur in trials. Accordingly, a key feature of any TD model is the assumption about the representation of a CS on a moment-to-moment basis. Here, we evaluate the performance of the TD model with a heretofore unexplored range of classical conditioning tasks. To do so, we consider three stimulus representations that vary in their degree of temporal generalization and evaluate how the representation influences the performance of the TD model on these conditioning tasks.

  14. An Expedient Study on Back-Propagation (BPN) Neural Networks for Modeling Automated Evaluation of the Answers and Progress of Deaf Students' That Possess Basic Knowledge of the English Language and Computer Skills

    Science.gov (United States)

    Vrettaros, John; Vouros, George; Drigas, Athanasios S.

    This article studies the expediency of using neural networks technology and the development of back-propagation networks (BPN) models for modeling automated evaluation of the answers and progress of deaf students' that possess basic knowledge of the English language and computer skills, within a virtual e-learning environment. The performance of the developed neural models is evaluated with the correlation factor between the neural networks' response values and the real value data as well as the percentage measurement of the error between the neural networks' estimate values and the real value data during its training process and afterwards with unknown data that weren't used in the training process.

  15. Evaluation of Turbulence Models in Gas Dispersion

    OpenAIRE

    Moen, Alexander

    2016-01-01

    Several earlier model validation studies for predicting gas dispersion scenarios have been conducted for the three RANS two-equation eddy viscosity turbulence models, the standard k-ε (SKE), Re- Normalisation group k-ε (RNG) and Realizable k-ε (Realizable). However, these studies have mainly validated one or two of the models, and have mostly used one simulation case as a basis for determining which model is the best suited for predicting such scenarios. In addition, the studies have shown co...

  16. [Development of human embryonic stem cell model for toxicity evaluation].

    Science.gov (United States)

    Yu, Guang-yan; Cao, Tong; Ouyang, Hong-wei; Peng, Shuang-qing; Deng, Xu-liang; Li, Sheng-lin; Liu, He; Zou, Xiao-hui; Fu, Xin; Peng, Hui; Wang, Xiao-ying; Zhan, Yuan

    2013-02-18

    The current international standard for toxicity screening of biomedical devices and materials recommend the use of immortalized cell lines because of their homogeneous morphologies and infinite proliferation which provide good reproducibility for in vitro cytotoxicity screening. However, most of the widely used immortalized cell lines are derived from animals and may not be representative of normal human cell behavior in vivo, in particular in terms of the cytotoxic and genotoxic response. Therefore, It is vital to develop a model for toxicity evaluation. In our studies, two Chinese human embryonic stem cell (hESC) lines as toxicity model were established. hESC derived tissue/organ cell model for tissue/organ specific toxicity evaluation were developed. The efficiency and accuracy of using hESC model for cytoxicity, embryotoxicity and genotoxicity evaluation were confirmed. The results indicated that hESCs might be good tools for toxicity testing and biosafety evaluation in vitro.

  17. Developing a Model for Evaluation and Accreditation of Hospitals

    Directory of Open Access Journals (Sweden)

    AM Mosadegh Rad

    2005-10-01

    Full Text Available Background: Evaluation and accreditation of Health Care organizations has an important role in increasing the effectiveness and efficiency of these organizations and developing the quality of services provided. The current system of evaluation and accreditation of hospitals in Iran is based on structure only with out considering the context, process and output and this cause many problems for both health care providers and customers. Therefore, there is a pressing need for developing a model for health care systems’ evaluation and accreditation, which help these organizations to improve the quality of services. Method: The aim of this article is therefore: “To identify the strengths and weakness of the current system of evaluation and accreditation of hospitals in Iran, determining the ideal system of evaluation and accreditation to develop a model so that health care organizations aiming at achieving effectiveness and efficiency”. A descriptive study using a cross-sectional survey for data collection performed. All of hospital managers and hospital evaluators in Isfahan province were studied via a self administrated questionnaire (53 managers and 30 evaluators. This questionnaire specifies the respondents’ opinions about the current and ideal system of evaluation and accreditation of hospitals. Data was analyzed via SPSS11 software. Findings: The mean score of current system of evaluation and accreditation of hospitals was 3.12 0.83 and 4.41 0.34 (in a 5 scale.The mean score of structure, process and outcome were 3.10.73, 3.120.91and 3.091 in the current system of hospital evaluation respectively. From the view points of hospital managers and evaluators the differences between values of current and ideal scores of evaluation and accreditation system were statistically significant (P< 0.05. Therefore, there is a need for developing a model for hospital evaluation and accreditation. Based on these results an empirical model

  18. Evaluation of EOR Processes Using Network Models

    DEFF Research Database (Denmark)

    Larsen, Jens Kjell; Krogsbøll, Anette

    1998-01-01

    The report consists of the following parts: 1) Studies of wetting properties of model fluids and fluid mixtures aimed at an optimal selection of candidates for micromodel experiments. 2) Experimental studies of multiphase transport properties using physical models of porous networks (micromodels)...

  19. Toward a general evaluation model for soil respiration (GEMSR)

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Soil respiration is an important component of terrestrial carbon budget. Its accurate evaluation is es- sential to the study of terrestrial carbon source/sink. Studies on soil respiration at present mostly focus on the temporal variations and the controlling factors of soil respiration, but its spatial variations and controlling factors draw less attention. Moreover, the evaluation models for soil respiration at present include only the effects of water and heat factors, while the biological and soil factors controlling soil respiration and their interactions with water and heat factors have not been considered yet. These models are not able to accurately evaluate soil respiration in different vegetation/terrestrial ecosystems at different temporal and spatial scales. Thus, a general evaluation model for soil respiration (GEMSR) including the interacting meteorological (water and heat factors), soil nutrient and biological factors is suggested in this paper, and the basic procedure developing GEMSR and the research tasks of soil respiration in the future are also discussed.

  20. Toward a general evaluation model for soil respiration (GEMSR)

    Institute of Scientific and Technical Information of China (English)

    ZHOU GuangSheng; JIA BingRui; HAN GuangXuan; ZHOU Li

    2008-01-01

    Soil respiration is an important component of terrestrial carbon budget. Its accurate evaluation is essential to the study of terrestrial carbon source/sink. Studies on soil respiration at present mostly focus on the temporal variations and the controlling factors of soil respiration, but its spatial variations and controlling factors draw less attention. Moreover, the evaluation models for soil respiration at present include only the effects of water and heat factors, while the biological and soil factors controlling soil respiration and their interactions with water and heat factors have not been considered yet. These models are not able to accurately evaluate soil respiration in different vegetation/terrestrial ecosystems at different temporal and spatial scales. Thus, a general evaluation model for soil respiration (GEMSR)including the interacting meteorological (water and heat factors), soil nutrient and biological factors is suggested in this paper, and the basic procedure developing GEMSR and the research tasks of soil respiration in the future are also discussed.

  1. Evaluation of the effect of consuming an energy drink on the concentration of glucose and triacylglycerols and on fatty tissue deposition. A model study

    Directory of Open Access Journals (Sweden)

    Joanna Sadowska

    2012-09-01

    Full Text Available   Background. The animal model study was aimed at evaluating the effect of diet composition and energy drink intake on body weight, accumulation and distribution of deposited fatty tissue, and concentrations of glucose and triacylglycerols in blood plasma. Material and methods. The experiment was carried out on 30 male rats. The animals were sorted into three groups, fed on group I – standard feed, groups II and III – modified feed, in which part of whole wheat and corn grains were isocalorically substituted with wheat flour and saccharose. Animals from groups I and II were receiving settled tap water for drinking, whereas these from group III were administered 3 ml of an energy drink, and then were provided drinking water. Results. In analysing the results obtained it was stated that the addition of the energy drink to diet affected diminished body weight gains of the animals (per energy unit in the diet as compared to the group of animals fed modified diet. The animals receiving the energy drink were additionally characterised by a lower content of peri-intestinal and intramuscular fatty tissue, whereas were found to deposit significantly higher amounts of peri-cardiac fatty tissue. Samples of blood plasma of these animals were found to contain a significantly higher concentration of glucose, compared to those of the animals fed modified diet. In turn, the concentration of triacylglycerols was comparable in all groups of animals. Conclusions. The analysis of results achieved enabled concluding that the addition of energy drink to diet was significantly modifying the rate and tendency of metabolic changes, which was manifested in: increased glucose concentration in blood plasma, diminished body weight gains of the animals and deposition of peri-cardial fat.  

  2. Evaluation of the effect of consuming an energy drink on the concentration of glucose and triacylglycerols and on fatty tissue deposition. A model study.

    Science.gov (United States)

    Sadowska, Joanna

    2012-01-01

    BACKGROUND. The animal model study was aimed at evaluating the effect of diet composition and energy drink intake on body weight, accumulation and distribution of deposited fatty tissue, and concentrations of glucose and triacylglycerols in blood plasma. The experiment was carried out on 30 male rats. The animals were sorted into three groups, fed on group I - standard feed, groups II and III - modified feed, in which part of whole wheat and corn grains were isocalorically substituted with wheat flour and saccharose. Animals from groups I and II were receiving settled tap water for drinking, whereas these from group III were administered 3 ml of an energy drink, and then were provided drinking water. In analysing the results obtained it was stated that the addition of the energy drink to diet affected diminished body weight gains of the animals (per energy unit in the diet) as compared to the group of animals fed modified diet. The animals receiving the energy drink were additionally characterised by a lower content of peri-intestinal and intramuscular fatty tissue, whereas were found to deposit significantly higher amounts of peri-cardiac fatty tissue. Samples of blood plasma of these animals were found to contain a significantly higher concentration of glucose, compared to those of the animals fed modified diet. In turn, the concentration of triacylglycerols was comparable in all groups of animals. The analysis of results achieved enabled concluding that the addition of energy drink to diet was significantly modifying the rate and tendency of metabolic changes, which was manifested in: increased glucose concentration in blood plasma, diminished body weight gains of the animals and deposition of peri-cardial fat.

  3. Testing and Treating Women after Unsuccessful Conservative Treatments for Overactive Bladder or Mixed Urinary Incontinence: A Model-Based Economic Evaluation Based on the BUS Study

    Science.gov (United States)

    Barton, Pelham; Middleton, Lee J.; Deeks, Jonathan J.; Daniels, Jane P.; Latthe, Pallavi; Coomarasamy, Arri; Rachaneni, Suneetha; McCooty, Shanteela; Verghese, Tina S.; Roberts, Tracy E.

    2016-01-01

    Objective To compare the cost-effectiveness of bladder ultrasonography, clinical history, and urodynamic testing in guiding treatment decisions in a secondary care setting for women failing first line conservative treatment for overactive bladder or urgency-predominant mixed urinary incontinence. Design Model-based economic evaluation from a UK National Health Service (NHS) perspective using data from the Bladder Ultrasound Study (BUS) and secondary sources. Methods Cost-effectiveness analysis using a decision tree and a 5-year time horizon based on the outcomes of cost per woman successfully treated and cost per Quality-Adjusted Life-Year (QALY). Deterministic and probabilistic sensitivity analyses, and a value of information analysis are also undertaken. Results Bladder ultrasonography is more costly and less effective test-treat strategy than clinical history and urodynamics. Treatment on the basis of clinical history alone has an incremental cost-effectiveness ratio (ICER) of £491,100 per woman successfully treated and an ICER of £60,200 per QALY compared with the treatment of all women on the basis of urodynamics. Restricting the use of urodynamics to women with a clinical history of mixed urinary incontinence only is the optimal test-treat strategy on cost-effectiveness grounds with ICERs of £19,500 per woman successfully treated and £12,700 per QALY compared with the treatment of all women based upon urodynamics. Conclusions remained robust to sensitivity analyses, but subject to large uncertainties. Conclusions Treatment based upon urodynamics can be seen as a cost-effective strategy, and particularly when targeted at women with clinical history of mixed urinary incontinence only. Further research is needed to resolve current decision uncertainty. PMID:27513926

  4. Improvement of procedures for evaluating photochemical models. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Tesche, T.W.; Lurmann, F.R.; Roth, P.M.; Georgopoulos, P.; Seinfeld, J.H.

    1990-08-01

    The study establishes a set of procedures that should be used by all groups evaluating the performance of a photochemical model application. A set of ten numerical measures are recommended for evaluating a photochemical model's accuracy in predicting ozone concentrations. Nine graphical methods and six investigative simulations are also recommended to give additional insight into model performance. Standards are presented that each modeling study should try to meet. To complement the operational model evaluation procedures, several diagnostic procedures are suggested. The sensitivity of the model to uncertainties in hydrocarbon emission rates and speciation, and other parameters should be assessed. Uncertainty bounds of key input variables and parameters can be propagated through the model to provide estimated uncertainties in the ozone predictions. Comparisons between measurements and predictions of species other than ozone will help ensure that the model is predicting the right ozone for the right reasons. Plotting concentrations residuals (differences) against a variety of variables may give insight into the reasons for poor model performance. Mass flux and balance calculations can identify the relative importance of emissions and transport. The study also identifies testing a model's response to emission changes as the most important research need. Another important area is testing the emissions inventory.

  5. Two models for evaluating landslide hazards

    Science.gov (United States)

    Davis, J.C.; Chung, C.-J.; Ohlmacher, G.C.

    2006-01-01

    Two alternative procedures for estimating landslide hazards were evaluated using data on topographic digital elevation models (DEMs) and bedrock lithologies in an area adjacent to the Missouri River in Atchison County, Kansas, USA. The two procedures are based on the likelihood ratio model but utilize different assumptions. The empirical likelihood ratio model is based on non-parametric empirical univariate frequency distribution functions under an assumption of conditional independence while the multivariate logistic discriminant model assumes that likelihood ratios can be expressed in terms of logistic functions. The relative hazards of occurrence of landslides were estimated by an empirical likelihood ratio model and by multivariate logistic discriminant analysis. Predictor variables consisted of grids containing topographic elevations, slope angles, and slope aspects calculated from a 30-m DEM. An integer grid of coded bedrock lithologies taken from digitized geologic maps was also used as a predictor variable. Both statistical models yield relative estimates in the form of the proportion of total map area predicted to already contain or to be the site of future landslides. The stabilities of estimates were checked by cross-validation of results from random subsamples, using each of the two procedures. Cell-by-cell comparisons of hazard maps made by the two models show that the two sets of estimates are virtually identical. This suggests that the empirical likelihood ratio and the logistic discriminant analysis models are robust with respect to the conditional independent assumption and the logistic function assumption, respectively, and that either model can be used successfully to evaluate landslide hazards. ?? 2006.

  6. 基于BSC的企业知识管理绩效评价模型及评价方法研究%Study on Performance Evaluation Model and Evaluation Method of Enterprise Knowledge Management Based on Balanced Score Card

    Institute of Scientific and Technical Information of China (English)

    张瑞红

    2011-01-01

    This article analyzes the relationship between balanced score card and knowledge management performance evaluation , and constructs the fuzzy comprehensive evaluation model of the performance evaluation indicators system based on balanced score card by analytic hierarchy process. Finally, the paper uses the model to evaluate the knowledge management performance by AHP - FCE. A quantifiable scientific evaluation method is provided.%分析出平衡计分卡和知识管理绩效评价的关系,应用层次分析法从平衡计分卡角度构建了知识管理绩效评价指标体系的三层模糊综合评价模型,结合该模型运用AHP-FCE方法对知识管理绩效进行评价,为知识管理绩效评价提供了可量化的科学评价方法.

  7. Research on Maintainability Evaluation Model Based on Fuzzy Theory

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Maintainability influencing attributes are analyzed, their weight and value calculating methods are given, and the maintainability fuzzy evaluation method is proposed based on the relative closeness. According to the maintenance task simulation operated in virtual environment, the maintainability virtual evaluation model is built by analyzing the maintenance task for each replaceable unit of product.At last, a case study is given based upon the main landing gear system of a certain type civil aircraft, and the result indicates that the model is suitable for maintainability qualitative evaluation and can support maintainability concurrent design.

  8. Evaluating smooth muscle cells from CaCl2-induced rat aortal expansions as a surrogate culture model for study of elastogenic induction of human aneurysmal cells.

    Science.gov (United States)

    Gacchina, Carmen; Brothers, Thomas; Ramamurthi, Anand

    2011-08-01

    Regression of abdominal aortic aneurysms (AAAs) via regeneration of new elastic matrix is constrained by poor elastin synthesis by adult vascular cells and absence of methods to stimulate the same. We recently showed hyaluronan oligomers (HA-o) and TGF-β1 (termed elastogenic factors) to enhance elastin synthesis and matrix formation by healthy rat aortic smooth muscle cells (RASMCs). We also determined that these factors could likewise elastogenically induce aneurysmal RASMCs isolated from periadventitial CaCl(2)-injury induced rat AAAs (aRASMCs). However, the factor doses should be increased for these diseased cell types, as even when induced, elastic matrix amounts are roughly one order of magnitude lower than those produced by healthy RASMCs. We presently investigate the dose-specific elastogenic effects of HA-o (0-20  μg/mL) and TGF-β1 (0-10  ng/mL) factors on aRASMCs and compare their phenotype and elastogenic responses to those of human AAA-derived SMCs (aHASMCs); we seek to determine whether aRASMCs are appropriate surrogate cell types to study in the context of inducing elastic matrix regeneration within human AAAs. The periadventitial CaCl(2)-injury model of AAAs exhibits many of the pathological characteristics of human AAAs, including similarities in terms of decreased SMC contractile activity, enhanced proliferation, and reduced elastogenic capacity of aneurysmal SMCs (relative to healthy SMCs) when isolated and expanded in culture. Both aRASMCs and aHASMCs can be elastogenically stimulated by HA-o and TGF-β1 and show broadly similar trends in their dose-specific responses to these factors. However, compared with aHASMCs, aRASMCs appear to be far less elastogenically inducible. This may be due to differences in maturity of the AAAs studied, with the CaCl(2)-injury induced aortal expansion barely qualifying as an aneurysm and the human AAA representing a more well-developed condition. Further study of SMCs from stage-matched CaCl(2)-injury

  9. Global daily reference evapotranspiration modeling and evaluation

    Science.gov (United States)

    Senay, G.B.; Verdin, J.P.; Lietzow, R.; Melesse, Assefa M.

    2008-01-01

    Accurate and reliable evapotranspiration (ET) datasets are crucial in regional water and energy balance studies. Due to the complex instrumentation requirements, actual ET values are generally estimated from reference ET values by adjustment factors using coefficients for water stress and vegetation conditions, commonly referred to as crop coefficients. Until recently, the modeling of reference ET has been solely based on important weather variables collected from weather stations that are generally located in selected agro-climatic locations. Since 2001, the National Oceanic and Atmospheric Administration's Global Data Assimilation System (GDAS) has been producing six-hourly climate parameter datasets that are used to calculate daily reference ET for the whole globe at 1-degree spatial resolution. The U.S. Geological Survey Center for Earth Resources Observation and Science has been producing daily reference ET (ETo) since 2001, and it has been used on a variety of operational hydrological models for drought and streamflow monitoring all over the world. With the increasing availability of local station-based reference ET estimates, we evaluated the GDAS-based reference ET estimates using data from the California Irrigation Management Information System (CIMIS). Daily CIMIS reference ET estimates from 85 stations were compared with GDAS-based reference ET at different spatial and temporal scales using five-year daily data from 2002 through 2006. Despite the large difference in spatial scale (point vs. ???100 km grid cell) between the two datasets, the correlations between station-based ET and GDAS-ET were very high, exceeding 0.97 on a daily basis to more than 0.99 on time scales of more than 10 days. Both the temporal and spatial correspondences in trend/pattern and magnitudes between the two datasets were satisfactory, suggesting the reliability of using GDAS parameter-based reference ET for regional water and energy balance studies in many parts of the world

  10. CTBT integrated verification system evaluation model supplement

    Energy Technology Data Exchange (ETDEWEB)

    EDENBURN,MICHAEL W.; BUNTING,MARCUS; PAYNE JR.,ARTHUR C.; TROST,LAWRENCE C.

    2000-03-02

    Sandia National Laboratories has developed a computer based model called IVSEM (Integrated Verification System Evaluation Model) to estimate the performance of a nuclear detonation monitoring system. The IVSEM project was initiated in June 1994, by Sandia's Monitoring Systems and Technology Center and has been funded by the U.S. Department of Energy's Office of Nonproliferation and National Security (DOE/NN). IVSEM is a simple, ''top-level,'' modeling tool which estimates the performance of a Comprehensive Nuclear Test Ban Treaty (CTBT) monitoring system and can help explore the impact of various sensor system concepts and technology advancements on CTBT monitoring. One of IVSEM's unique features is that it integrates results from the various CTBT sensor technologies (seismic, in sound, radionuclide, and hydroacoustic) and allows the user to investigate synergy among the technologies. Specifically, IVSEM estimates the detection effectiveness (probability of detection), location accuracy, and identification capability of the integrated system and of each technology subsystem individually. The model attempts to accurately estimate the monitoring system's performance at medium interfaces (air-land, air-water) and for some evasive testing methods such as seismic decoupling. The original IVSEM report, CTBT Integrated Verification System Evaluation Model, SAND97-25 18, described version 1.2 of IVSEM. This report describes the changes made to IVSEM version 1.2 and the addition of identification capability estimates that have been incorporated into IVSEM version 2.0.

  11. CTBT integrated verification system evaluation model supplement

    Energy Technology Data Exchange (ETDEWEB)

    EDENBURN,MICHAEL W.; BUNTING,MARCUS; PAYNE JR.,ARTHUR C.; TROST,LAWRENCE C.

    2000-03-02

    Sandia National Laboratories has developed a computer based model called IVSEM (Integrated Verification System Evaluation Model) to estimate the performance of a nuclear detonation monitoring system. The IVSEM project was initiated in June 1994, by Sandia's Monitoring Systems and Technology Center and has been funded by the U.S. Department of Energy's Office of Nonproliferation and National Security (DOE/NN). IVSEM is a simple, ''top-level,'' modeling tool which estimates the performance of a Comprehensive Nuclear Test Ban Treaty (CTBT) monitoring system and can help explore the impact of various sensor system concepts and technology advancements on CTBT monitoring. One of IVSEM's unique features is that it integrates results from the various CTBT sensor technologies (seismic, in sound, radionuclide, and hydroacoustic) and allows the user to investigate synergy among the technologies. Specifically, IVSEM estimates the detection effectiveness (probability of detection), location accuracy, and identification capability of the integrated system and of each technology subsystem individually. The model attempts to accurately estimate the monitoring system's performance at medium interfaces (air-land, air-water) and for some evasive testing methods such as seismic decoupling. The original IVSEM report, CTBT Integrated Verification System Evaluation Model, SAND97-25 18, described version 1.2 of IVSEM. This report describes the changes made to IVSEM version 1.2 and the addition of identification capability estimates that have been incorporated into IVSEM version 2.0.

  12. Evaluating spatial patterns in hydrological modelling

    DEFF Research Database (Denmark)

    Koch, Julian

    is not fully exploited by current modelling frameworks due to the lack of suitable spatial performance metrics. Furthermore, the traditional model evaluation using discharge is found unsuitable to lay confidence on the predicted catchment inherent spatial variability of hydrological processes in a fully...... the contiguous United Sates (10^6 km2). To this end, the thesis at hand applies a set of spatial performance metrics on various hydrological variables, namely land-surface-temperature (LST), evapotranspiration (ET) and soil moisture. The inspiration for the applied metrics is found in related fields...

  13. Metrics and Evaluation Models for Accessible Television

    DEFF Research Database (Denmark)

    Li, Dongxiao; Looms, Peter Olaf

    2014-01-01

    The adoption of the UN Convention on the Rights of Persons with Disabilities (UN CRPD) in 2006 has provided a global framework for work on accessibility, including information and communication technologies and audiovisual content. One of the challenges facing the application of the UN CRPD is te...... and evaluation models for access service provision, the paper identifies options that could facilitate the evaluation of UN CRPD outcomes and suggests priorities for future research in this area....... number of platforms on which audiovisual content needs to be distributed, requiring very clear multiplatform architectures to facilitate interworking and assure interoperability. As a consequence, the regular evaluations of progress being made by signatories to the UN CRPD protocol are difficult...

  14. Evaluation of CNN as anthropomorphic model observer

    Science.gov (United States)

    Massanes, Francesc; Brankov, Jovan G.

    2017-03-01

    Model observers (MO) are widely used in medical imaging to act as surrogates of human observers in task-based image quality evaluation, frequently towards optimization of reconstruction algorithms. In this paper, we explore the use of convolutional neural networks (CNN) to be used as MO. We will compare CNN MO to alternative MO currently being proposed and used such as the relevance vector machine based MO and channelized Hotelling observer (CHO). As the success of the CNN, and other deep learning approaches, is rooted in large data sets availability, which is rarely the case in medical imaging systems task-performance evaluation, we will evaluate CNN performance on both large and small training data sets.

  15. Phoenix Metropolitan Model Deployment Initiative Evaluation Report

    OpenAIRE

    Zimmerman, C; Marks, J.; Jenq, J.; Cluett, Chris; DeBlasio, Allan; Lappin, Jane; Rakha, Hesham A.; Wunderlich, K

    2000-01-01

    This report presents the evaluation results of the Phoenix, Arizona Metropolitan Model Deployment Initiative (MMDI). The MMDI was a three-year program of the Intelligent Transportation Systems (ITS) Joint Program Office of the U.S. Department of Transportation. It focused on aggressive deployment of ITS at four sites across the United States, including the metropolitan areas of San Antonio, Seattle, NY/NJ/Connecticut as well as Phoenix. The focus of the deployments was on integration of exist...

  16. Implicit moral evaluations: A multinomial modeling approach.

    Science.gov (United States)

    Cameron, C Daryl; Payne, B Keith; Sinnott-Armstrong, Walter; Scheffer, Julian A; Inzlicht, Michael

    2017-01-01

    Implicit moral evaluations-i.e., immediate, unintentional assessments of the wrongness of actions or persons-play a central role in supporting moral behavior in everyday life. Yet little research has employed methods that rigorously measure individual differences in implicit moral evaluations. In five experiments, we develop a new sequential priming measure-the Moral Categorization Task-and a multinomial model that decomposes judgment on this task into multiple component processes. These include implicit moral evaluations of moral transgression primes (Unintentional Judgment), accurate moral judgments about target actions (Intentional Judgment), and a directional tendency to judge actions as morally wrong (Response Bias). Speeded response deadlines reduced Intentional Judgment but not Unintentional Judgment (Experiment 1). Unintentional Judgment was stronger toward moral transgression primes than non-moral negative primes (Experiments 2-4). Intentional Judgment was associated with increased error-related negativity, a neurophysiological indicator of behavioral control (Experiment 4). Finally, people who voted for an anti-gay marriage amendment had stronger Unintentional Judgment toward gay marriage primes (Experiment 5). Across Experiments 1-4, implicit moral evaluations converged with moral personality: Unintentional Judgment about wrong primes, but not negative primes, was negatively associated with psychopathic tendencies and positively associated with moral identity and guilt proneness. Theoretical and practical applications of formal modeling for moral psychology are discussed. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Are ultrasound-guided ophthalmic blocks injurious to the eye? A comparative rabbit model study of two ultrasound devices evaluating intraorbital thermal and structural changes.

    Science.gov (United States)

    Palte, Howard D; Gayer, Steven; Arrieta, Esdras; Scot Shaw, Eric; Nose, Izuru; Lee, Elizabete; Arheart, Kristopher L; Dubovy, Sander; Birnbach, David J; Parel, Jean-Marie

    2012-07-01

    Since Atkinson's original description of retrobulbar block in 1936, needle-based anesthetic techniques have become integral to ophthalmic anesthesia. These techniques are unfortunately associated with rare, grave complications such as globe perforation. Ultrasound has gained widespread acceptance for peripheral nerve blockade, but its translation to ocular anesthesia has been hampered because sonic energy, in the guise of thermal or biomechanical insult, is potentially injurious to vulnerable eye tissue. The US Food and Drug Administration (FDA) has defined guidelines for safe use of ultrasound for ophthalmic examination, but most ultrasound devices used by anesthesiologists are not FDA-approved for ocular application because they generate excessive energy. Regulating agencies state that ultrasound examinations can be safely undertaken as long as tissue temperatures do not increase >1.5°C above physiological levels. Using a rabbit model, we investigated the thermal and mechanical ocular effects after prolonged ultrasonic exposure to single orbital- and nonorbital-rated devices. In a dual-phase study, aimed at detecting ocular injury, the eyes of 8 rabbits were exposed to continuous 10-minute ultrasound examinations from 2 devices: (1) the Sonosite Micromaxx (nonorbital rated) and (2) the Sonomed VuMax (orbital rated) machines. In phase I, temperatures were continuously monitored via thermocouples implanted within specific eye structures (n = 4). In phase II the eyes were subjected to ultrasonic exposure without surgical intervention (n = 4). All eyes underwent light microscopy examinations, followed at different intervals by histology evaluations conducted by an ophthalmic pathologist. Temperature changes were monitored in the eyes of 4 rabbits. The nonorbital-rated transducer produced increases in ocular tissue temperature that surpassed the safe limit (increases >1.5°C) in the lens of 3 rabbits (at 5.0, 5.5, and 1.5 minutes) and cornea of 2 rabbits (both at 1

  18. Evaluation of adenosine preconditioning with {sup 99m}Tc-His{sub 10}-annexin V in a porcine model of myocardium ischemia and reperfusion injury: preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Ye Fei [Department of Cardiology, Nanjing First Hospital Affiliated to Nanjing Medical University, 68 Changle Road, Nanjing 210006 (China); Fang Wei [Cardiovascular Institute and Fuwai Hospital, No. 167 Bei-Li-Shi-Lu, Beijing 100037 (China); Wang Feng, E-mail: fengwang1972cn@gmail.co [Department of Nuclear Medicine, Nanjing First Hospital Affiliated to Nanjing Medical University, 68 Changle Road, Nanjing 210006 (China); State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, College of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China); Hua Zichun [State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, College of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China); Wang Zizheng [Department of Nuclear Medicine, Nanjing First Hospital Affiliated to Nanjing Medical University, 68 Changle Road, Nanjing 210006 (China); Yang Xiang [State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, College of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)

    2011-05-15

    Purpose: The goal of this study was to evaluate the feasibility of {sup 99m}Tc-His{sub 10}-annexin V for the detection of acute myocardial cell death and to assess the effect of adenosine preconditioning in a porcine model of myocardium ischemia and reperfusion injury (RI). Materials and Methods: {sup 99m}Tc-His{sub 10}-annexin V was prepared by one-step direct labeling, and RCP and radiostability were tested. The binding of {sup 99m}Tc-His{sub 10}-annexin V to apoptosis was validated in vitro using camptothecin-induced Jurkat cells. In vivo biodistribution was determined in mice by the dissection method. Ischemia of 20-30 min was induced by balloon occlusion of the epicardial coronary artery of the porcine model (n=14). Adenosine was infused intravenously in six pigs before coronary occlusion. {sup 99m}Tc-His{sub 10}-annexin V (n=12) was injected intravenously at 1 h after reperfusion. SPECT/CT was acquired at 3 h postinjection. Myocardial perfusion imaging (MPI) with {sup 99m}Tc-MIBI was also performed 1 day after His{sub 10}-annexin V imaging. Cardiac tissues were analyzed postmortem using hematoxylin-and-eosin and TUNEL staining. Caspase-3 activity was measured to confirm the presence of apoptosis. Results: {sup 99m}Tc-His{sub 10}-annexin V had a RCP >98% and high stability 2 h after radiolabeling; it could bind to apoptotic cells with high affinity. Biodistribution of {sup 99m}Tc-His{sub 10}-annexin V showed a predominant uptake in the kidney and relatively low uptake in the myocardium, liver and gastrointestinal tract; rapid clearance from blood and kidney was observed. In the untreated group, intense uptake of His{sub 10}-annexin V was visualized in the defect which was shown in MPI, whereas in the adenosine group a mild uptake of {sup 99m}Tc-His{sub 10}-annexin was found in the risk area which showed no defects in the {sup 99m}Tc-MIBI image. TUNEL staining and activated caspase-3 confirmed the ongoing apoptosis in RI. Adenosine preconditioning significantly

  19. Early evaluation of the therapeutic effectiveness in children with epilepsy by quantitative EEG: a model of Mozart K.448 listening--a preliminary study.

    Science.gov (United States)

    Lin, Lung-Chang; Ouyang, Chen-Sen; Chiang, Ching-Tai; Wu, Hui-Chuan; Yang, Rei-Cheng

    2014-10-01

    There are many treatments being developed for patients with epilepsy, including anti-epileptic drugs, ketogenic diet and vagus nerve stimulation. To date, there is a lack of valid methods to predict at an early stage the therapeutic effects on patients with epilepsy who receive one of these treatments. Our previous studies revealed that epileptiform discharges which were observed in patients with epilepsy were significantly decreased while listening to Mozart K.448. In this study, we attempted to develop a useful marker by utilizing a quantitative electroencephalogram (qEEG) method in analyzing the features of EEG to early evaluate the effect of the music on children with epilepsy, even without epileptiform discharges. EEG segments from 19 Taiwanese children who were selected from a large screen study of music effect (eight boys and 11 girls) diagnosed with epilepsy were analyzed. EEG examinations were performed in two parallel periods in each patient; before, and while listening to Mozart K.448's first movement (8 min 22s) and EEG data were compared by qEEG. EEG segments were classified into music effective/ineffective group. The term "effective" was defined as patient exposure to music resulting in over a 25% reduction in epileptiform discharges. On the contrary, the term "ineffective" was defined as patient exposure to music resulting in less than a 5% reduction in epileptiform discharges. There were four global feature descriptors selected for the music effective/ineffective classification. Two descriptors, DecorrTime_avg_AVG and DecorrTime_std_AVG, were related to the EEG feature "decorrelation" whereas the other two descriptors, RelPowGamma_avg_SNR and RelPowGamma_std_SNR, were related to "relative power of gamma." There were significantly higher RelPowGamma_std_SNR (0.190±0.133 vs. -0.026±0.119, p=0.0029), DecorrTime_std_AVG (0.005±0.004 vs. 0.0003±0.0016, p=0.0055), DecorrTime_avg_AVG (0.005±0.005 vs. -0.002±0.008, p=0.0179), and Rel

  20. Can legal research benefit from evaluation studies?

    Directory of Open Access Journals (Sweden)

    Frans L. Leeuw

    2011-01-01

    Full Text Available The article describes what evaluation studies have to offer to legal research. Several cases and types of evaluations are presented, in relation to legal or semi-legal questions. Also, a short overview of the contemporary history of evaluation studies is presented. Finally, it will address the question of how to ensure that in legal research and in legal training attention is paid to theories, designs and methods of evaluation studies.

  1. Acceptance criteria for urban dispersion model evaluation

    Science.gov (United States)

    Hanna, Steven; Chang, Joseph

    2012-05-01

    The authors suggested acceptance criteria for rural dispersion models' performance measures in this journal in 2004. The current paper suggests modified values of acceptance criteria for urban applications and tests them with tracer data from four urban field experiments. For the arc-maximum concentrations, the fractional bias should have a magnitude 0.3. For all data paired in space, for which a threshold concentration must always be defined, the normalized absolute difference should be SCIPUFF dispersion model with the urban canopy option and the urban dispersion model (UDM) option. In each set of evaluations, three or four likely options are tested for meteorological inputs (e.g., a local building top wind speed, the closest National Weather Service airport observations, or outputs from numerical weather prediction models). It is found that, due to large natural variability in the urban data, there is not a large difference between the performance measures for the two model options and the three or four meteorological input options. The more detailed UDM and the state-of-the-art numerical weather models do provide a slight improvement over the other options. The proposed urban dispersion model acceptance criteria are satisfied at over half of the field experiments.

  2. Turbulence Model Evaluation Study for a Secondary Flow and a Flow Pulsation in the Sub-Channels of an 18-Finned Rod Bundle by Using Computational Fluid Dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jong Hark; Chae, Hee Taek; Park, Cheol; Kim, Heon Il

    2008-09-15

    Since the heat flux of the rod type fuel used in the HANARO, a research reactor being operated in the KAERI, is substantially higher than the heat flux of power reactors, the HANARO fuel has 8 longitudinal fins for enhancing the heat release from the fuel rod surface. This unique shape of a nuclear fuel led us to study the flows and thermal hydraulic characteristics of it. Especially because the flows through the narrow channels built up by these finned rod fuels would be different from the flow characteristics in the coolant channels formed by bare rod fuels, some experimental studies to investigate the flow behaviors and structures in a finned rod bundle were done by other researchers. But because of the very complex geometries of the flow channels in the finned rod bundle only allowed us to obtain limited information about the flow characteristics, a numerical study by a computational fluid dynamics technique has been adopted to elucidate more about such a complicated flow in a finned rod bundle. In this study, for the development of an adequate computational model to simulate such a complex geometry, a mesh sensitivity study and the effects of various turbulence models were examined. The CFD analysis results were compared with the experimental results. Some of them have a good agreement with the experimental results. All linear eddy viscosity turbulence models could hardly predict the secondary flows near the fuel surfaces and in the sub-channel, but the RSM (Reynolds Stress Model) revealed very different results from the eddy viscosity turbulence models. In the transient analysis all turbulence model predicted flow pulsation at the center of a subchannel as well as at the gap between rods in spite of large P/D. The flow pulsation showed different results with turbulence models and the location in the sub-channels.

  3. Evaluation of Model Fit in Cognitive Diagnosis Models

    Science.gov (United States)

    Hu, Jinxiang; Miller, M. David; Huggins-Manley, Anne Corinne; Chen, Yi-Hsin

    2016-01-01

    Cognitive diagnosis models (CDMs) estimate student ability profiles using latent attributes. Model fit to the data needs to be ascertained in order to determine whether inferences from CDMs are valid. This study investigated the usefulness of some popular model fit statistics to detect CDM fit including relative fit indices (AIC, BIC, and CAIC),…

  4. Evaluation of Artificial Intelligence Based Models for Chemical Biodegradability Prediction

    Directory of Open Access Journals (Sweden)

    Aleksandar Sabljic

    2004-12-01

    Full Text Available This study presents a review of biodegradability modeling efforts including a detailed assessment of two models developed using an artificial intelligence based methodology. Validation results for these models using an independent, quality reviewed database, demonstrate that the models perform well when compared to another commonly used biodegradability model, against the same data. The ability of models induced by an artificial intelligence methodology to accommodate complex interactions in detailed systems, and the demonstrated reliability of the approach evaluated by this study, indicate that the methodology may have application in broadening the scope of biodegradability models. Given adequate data for biodegradability of chemicals under environmental conditions, this may allow for the development of future models that include such things as surface interface impacts on biodegradability for example.

  5. Evaluation of spinal cord injury animal models

    Institute of Scientific and Technical Information of China (English)

    Ning Zhang; Marong Fang; Haohao Chen; Fangming Gou; Mingxing Ding

    2014-01-01

    Because there is no curative treatment for spinal cord injury, establishing an ideal animal model is important to identify injury mechanisms and develop therapies for individuals suffering from spinal cord injuries. In this article, we systematically review and analyze various kinds of animal models of spinal cord injury and assess their advantages and disadvantages for further studies.

  6. Transport properties site descriptive model. Guidelines for evaluation and modelling

    Energy Technology Data Exchange (ETDEWEB)

    Berglund, Sten [WSP Environmental, Stockholm (Sweden); Selroos, Jan-Olof [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)

    2004-04-01

    This report describes a strategy for the development of Transport Properties Site Descriptive Models within the SKB Site Investigation programme. Similar reports have been produced for the other disciplines in the site descriptive modelling (Geology, Hydrogeology, Hydrogeochemistry, Rock mechanics, Thermal properties, and Surface ecosystems). These reports are intended to guide the site descriptive modelling, but also to provide the authorities with an overview of modelling work that will be performed. The site descriptive modelling of transport properties is presented in this report and in the associated 'Strategy for the use of laboratory methods in the site investigations programme for the transport properties of the rock', which describes laboratory measurements and data evaluations. Specifically, the objectives of the present report are to: Present a description that gives an overview of the strategy for developing Site Descriptive Models, and which sets the transport modelling into this general context. Provide a structure for developing Transport Properties Site Descriptive Models that facilitates efficient modelling and comparisons between different sites. Provide guidelines on specific modelling issues where methodological consistency is judged to be of special importance, or where there is no general consensus on the modelling approach. The objectives of the site descriptive modelling process and the resulting Transport Properties Site Descriptive Models are to: Provide transport parameters for Safety Assessment. Describe the geoscientific basis for the transport model, including the qualitative and quantitative data that are of importance for the assessment of uncertainties and confidence in the transport description, and for the understanding of the processes at the sites. Provide transport parameters for use within other discipline-specific programmes. Contribute to the integrated evaluation of the investigated sites. The site descriptive

  7. A Qualitative and Quantitative Evaluation of 8 Clear Sky Models.

    Science.gov (United States)

    Bruneton, Eric

    2016-10-27

    We provide a qualitative and quantitative evaluation of 8 clear sky models used in Computer Graphics. We compare the models with each other as well as with measurements and with a reference model from the physics community. After a short summary of the physics of the problem, we present the measurements and the reference model, and how we "invert" it to get the model parameters. We then give an overview of each CG model, and detail its scope, its algorithmic complexity, and its results using the same parameters as in the reference model. We also compare the models with a perceptual study. Our quantitative results confirm that the less simplifications and approximations are used to solve the physical equations, the more accurate are the results. We conclude with a discussion of the advantages and drawbacks of each model, and how to further improve their accuracy.

  8. Study of construction of entrepreneurial competency model and evaluation%创业者胜任力模型构建及综合测评研究

    Institute of Scientific and Technical Information of China (English)

    毛翠云; 王世坤

    2012-01-01

    创业者胜任力对创业企业有着至关重要的作用.文章在以往创业者和创业者胜任素质理论的基础上,构建创业者胜任力模型,并在其基础上确定相应的测评指标体系,利用层次分析法确定各个指标权重,建立创业者胜任力测评规范指标体系,通过对创业者胜任力的综合测评并利用spss17.0对测评结果进行分析,为创业者以及创业者胜任力的开发与培养提供相应参考.%Entrepreneurial Competence plays a very important role on entrepreneurial enterprises. The paper constructs the entrepreneurial competency model and set up corresponding evaluate system based on previous theory of entrepreneurial competency. I use the analytic hierarchy process to determine the weight of each target and build the system of entrepreneur competency evaluation. I evaluate entrepreneurial competency and provide corresponding reference to entrepreneur, entrepreneurial competency development and training.

  9. Evaluation Statistics Computed for the Wave Information Studies (WIS)

    Science.gov (United States)

    2016-07-01

    wave models , including those of WIS, are influenced by meteorological forcing parameters, representation of the geographic area (e.g., bathymetry...statistical metrics to wave model evaluation are found in Zambresky (1989) and Cardone et al. (1996). These statistics were calculated in the...describes the statistical metrics used by the Wave Information Studies (WIS) and produced as part of the model evaluation process. INTRODUCTION: The

  10. NORTHERN OHIO AEROSOL STUDY: STAPHYLOCOCCUS AUREUS EVALUATION

    Science.gov (United States)

    A consortium of Universities, located in northwest Ohio have received funds to conduct a comprehensive evaluation of land applied biosolids in that state. This USDA funded study includes observing land application practices and evaluating biosolids, soils, runoff water and bioaer...

  11. NORTHERN OHIO AEROSOL STUDY: STAPHYLOCOCCUS AUREUS EVALUATION

    Science.gov (United States)

    A consortium of Universities, located in northwest Ohio have received funds to conduct a comprehensive evaluation of land applied biosolids in that state. This USDA funded study includes observing land application practices and evaluating biosolids, soils, runoff water and bioaer...

  12. A Bayesian approach for evaluation of the effect of water quality model parameter uncertainty on TMDLs: A case study of Miyun Reservoir.

    Science.gov (United States)

    Liang, Shidong; Jia, Haifeng; Xu, Changqing; Xu, Te; Melching, Charles

    2016-08-01

    Facing increasingly serious water pollution, the Chinese government is changing the environmental management strategy from solely pollutant concentration control to a Total Maximum Daily Load (TMDL) program, and water quality models are increasingly being applied to determine the allowable pollutant load in the TMDL. Despite the frequent use of models, few studies have focused on how parameter uncertainty in water quality models affect the allowable pollutant loads in the TMDL program, particularly for complicated and high-dimension water quality models. Uncertainty analysis for such models is limited by time-consuming simulation and high-dimensionality and nonlinearity in parameter spaces. In this study, an allowable pollutant load calculation platform was established using the Environmental Fluid Dynamics Code (EFDC), which is a widely applied hydrodynamic-water quality model. A Bayesian approach, i.e. the DiffeRential Evolution Adaptive Metropolis (DREAM) algorithm, which is a high-efficiency, multi-chain Markov Chain Monte Carlo (MCMC) method, was applied to assess the effects of parameter uncertainty on the water quality model simulations and its influence on the allowable pollutant load calculation in the TMDL program. Miyun Reservoir, which is the most important surface drinking water source for Beijing, suffers from eutrophication and was selected as a case study. The relations between pollutant loads and water quality indicators are obtained through a graphical method in the simulation platform. Ranges of allowable pollutant loads were obtained according to the results of parameter uncertainty analysis, i.e. Total Organic Carbon (TOC): 581.5-1030.6t·yr(-1); Total Phosphorus (TP): 23.3-31.0t·yr(-1); and Total Nitrogen (TN): 480-1918.0t·yr(-1). The wide ranges of allowable pollutant loads reveal the importance of parameter uncertainty analysis in a TMDL program for allowable pollutant load calculation and margin of safety (MOS) determination. The sources

  13. A preliminary study on a new model system to evaluate tumour-detection and tumour-purging protocols in ovarian cortex tissue intended for fertility preservation

    NARCIS (Netherlands)

    Peek, R.; Bastings, L.; Westphal, J.R.; Massuger, L.F.A.G.; Braat, D.D.M.; Beerendonk, C.C.M.

    2015-01-01

    STUDY QUESTION: Is it possible to create a model system that mimics ovarian metastatic disease in order to devise new strategies to detect cancer cells and prevent cancer cell transmission via ovarian tissue autotransplantation in cancer survivors? SUMMARY ANSWER: Injection of bovine or human

  14. Evaluating a novel resident role-modelling programme.

    Science.gov (United States)

    Sternszus, Robert; Steinert, Yvonne; Bhanji, Farhan; Andonian, Sero; Snell, Linda S

    2017-05-09

    Role modelling is a fundamental method by which students learn from residents. To our knowledge, however, resident-as-teacher curricula have not explicitly addressed resident role modelling. The purpose of this project was to design, implement and evaluate an innovative programme to teach residents about role modelling. The authors designed a resident role-modelling programme and incorporated it into the 2015 and 2016 McGill University resident-as-teacher curriculum. Influenced by experiential and social learning theories, the programme incorporated flipped-classroom and simulation approaches to teach residents to be aware and deliberate role models. Outcomes were assessed through a pre- and immediate post-programme questionnaire evaluating reaction and learning, a delayed post-programme questionnaire evaluating learning, and a retrospective pre-post questionnaire (1 month following the programme) evaluating self-reported behaviour changes. Thirty-three of 38 (87%) residents who participated in the programme completed the evaluation, with 25 residents (66%) completing all questionnaires. Participants rated the programme highly on a five-point Likert scale (where 1 = not helpful and 5 = very helpful; mean score, M = 4.57; standard deviation, SD = 0.50), and showed significant improvement in their perceptions of their importance as role models and their knowledge of deliberate role modelling. Residents also reported an increased use of deliberate role-modelling strategies 1 month after completing the programme. Resident-as-teacher curricula have not explicitly addressed resident role modelling DISCUSSION: The incorporation of resident role modelling into our resident-as-teacher curriculum positively influenced the participants' perceptions of their role-modelling abilities. This programme responds to a gap in resident training and has the potential to guide further programme development in this important and often overlooked area. © 2017 John Wiley & Sons

  15. Study on evaluation model of earthquake damage to clean water tank%清水池震害评估模型研究

    Institute of Scientific and Technical Information of China (English)

    高霖; 郭恩栋; 刘智; 洪广磊

    2013-01-01

    In order to assess the seismic damage of clean water tanks, based on the detailed earthquake damage data of clean water tanks from Haicheng earthquake and Tangshan earthquake, the phenomena and characteristics of clean water tanks subjected to earthquake damage are analyzed and the main influence factors are found. The least square method is used in the regression analysis of the earthquake damage data to obtained the regression coefficients of influence factors of earthquake damage under different conditions and to establish an empirical model to evaluate the earthquake damage of clean water tanks. The correlation coefficient of the model is 0. 661 and the standard deiation is 0.447. The model has an accuracy of 91. 2% by the regression discriminant analysis. According to the earthquake experience, the adjustment coefficients for new influence factors that are not considered in the model are given. Evaluation results are consistent with the actual damage to the clean water tanks in Wenchuan earthquake and Yushu earthquake, and etc. Thus, the model is preliminarily proved to be reliable.%为了评估清水池的地震破坏状态,基于海城地震、唐山地震中较详细的水池震害资料,分析了水池的主要震害现象、特征,并找出了影响水池震害的主要因素.采用最小二乘法对震害数据进行回归分析,得到了各震害影响因素不同情况下的回归系数取值,从而建立了清水池震害经验统计回归模型.经计算该模型的相关系数为0.661,标准差为0.447.经回判分析,模型回判成功率为91.2%.对于模型中未考虑到的震害影响因素,根据实际震害经验,给出新增影响因素的建议系数.对汶川、玉树等地震中遭到破坏的清水池进行评估,结果与实际震害基本相符,初步验证了该评估模型的可靠性.

  16. The Analysis of Several Models of Investment Value of Logistics Project Evaluation

    Directory of Open Access Journals (Sweden)

    Ke Qiu Cheng Zhou

    2013-01-01

    Full Text Available The study of the logistics project evaluation model features reviews the traditional value evaluation model. On the basis of this, using the fuzzy theory, we establish several logistics project evaluation models under fuzzy environment. The analysis of the respective characteristics and the comparison of the calculated results of the three models show that these models are important methods of investment value of logistics evaluation.

  17. Evaluation of onset of nucleate boiling models

    Energy Technology Data Exchange (ETDEWEB)

    Huang, LiDong [Heat Transfer Research, Inc., College Station, TX (United States)], e-mail: lh@htri.net

    2009-07-01

    This article discusses available models and correlations for predicting the required heat flux or wall superheat for the Onset of Nucleate Boiling (ONB) on plain surfaces. It reviews ONB data in the open literature and discusses the continuing efforts of Heat Transfer Research, Inc. in this area. Our ONB database contains ten individual sources for ten test fluids and a wide range of operating conditions for different geometries, e.g., tube side and shell side flow boiling and falling film evaporation. The article also evaluates literature models and correlations based on the data: no single model in the open literature predicts all data well. The prediction uncertainty is especially higher in vacuum conditions. Surface roughness is another critical criterion in determining which model should be used. However, most models do not directly account for surface roughness, and most investigators do not provide surface roughness information in their published findings. Additional experimental research is needed to improve confidence in predicting the required wall superheats for nucleation boiling for engineering design purposes. (author)

  18. Evaluation of CASP8 model quality predictions

    KAUST Repository

    Cozzetto, Domenico

    2009-01-01

    The model quality assessment problem consists in the a priori estimation of the overall and per-residue accuracy of protein structure predictions. Over the past years, a number of methods have been developed to address this issue and CASP established a prediction category to evaluate their performance in 2006. In 2008 the experiment was repeated and its results are reported here. Participants were invited to infer the correctness of the protein models submitted by the registered automatic servers. Estimates could apply to both whole models and individual amino acids. Groups involved in the tertiary structure prediction categories were also asked to assign local error estimates to each predicted residue in their own models and their results are also discussed here. The correlation between the predicted and observed correctness measures was the basis of the assessment of the results. We observe that consensus-based methods still perform significantly better than those accepting single models, similarly to what was concluded in the previous edition of the experiment. © 2009 WILEY-LISS, INC.

  19. Human Thermal Model Evaluation Using the JSC Human Thermal Database

    Science.gov (United States)

    Bue, Grant; Makinen, Janice; Cognata, Thomas

    2012-01-01

    Human thermal modeling has considerable long term utility to human space flight. Such models provide a tool to predict crew survivability in support of vehicle design and to evaluate crew response in untested space environments. It is to the benefit of any such model not only to collect relevant experimental data to correlate it against, but also to maintain an experimental standard or benchmark for future development in a readily and rapidly searchable and software accessible format. The Human thermal database project is intended to do just so; to collect relevant data from literature and experimentation and to store the data in a database structure for immediate and future use as a benchmark to judge human thermal models against, in identifying model strengths and weakness, to support model development and improve correlation, and to statistically quantify a model s predictive quality. The human thermal database developed at the Johnson Space Center (JSC) is intended to evaluate a set of widely used human thermal models. This set includes the Wissler human thermal model, a model that has been widely used to predict the human thermoregulatory response to a variety of cold and hot environments. These models are statistically compared to the current database, which contains experiments of human subjects primarily in air from a literature survey ranging between 1953 and 2004 and from a suited experiment recently performed by the authors, for a quantitative study of relative strength and predictive quality of the models.

  20. Advances in Application of Models in Soil Quality Evaluation

    Institute of Scientific and Technical Information of China (English)

    SI Zhi-guo; WANG Ji-jie; YU Yuan-chun; LIANG Guan-feng; CHEN Chang-ren; SHU Hong-lan

    2012-01-01

    Soil quality is a comprehensive reflection of soil properties.Since the soil quality concept was put forward in the 1970s,the quality of different type soils in different regions have been evaluated through a variety of evaluation methods,but it still lacks universal soil quantity evaluation models and methods.In this paper,the applications and prospects of grey relevancy comprehensive evaluation model,attribute hierarchical model,fuzzy comprehensive evaluation model,matter-element model,RAGA-based PPC /PPE model and GIS model in soil quality evaluation are reviewed.

  1. Study on Rough - ANN Model of Audit Indicators Evaluation%审计指标评价识别的Rough-ANN模型

    Institute of Scientific and Technical Information of China (English)

    徐向真

    2012-01-01

    由于审计指标体系的开放性,当需要甄别的指标结构相对简单的时候,比较容易处理,但是当面对更加复杂的的财务报表以及其他相关数据时,需要完善和建立的审许指标系统也会更加复杂.本文首先介绍了Rough集(粗糙集)和ANN(人工神经网络)理论的出现为审计指标识别带来的机会,分析了这种识别模型的确立的可能性,将Rough集和ANN相结合,构造了审计对象识别的Rough-ANN模型,并结合一个实例来验证此模型的可行性和有效性.%Audit indicator is an open system, so when the structure is relatively stmple, it is relatively easy to handle, but when the structure is more complex with financial statements and other relevant data, the need to improve the system of indicators will be more complex. This paper introduces the Rough set and ANN (artificial neural network) theory and the opportunities they bring to the audit indicator model. And the model will combine Rough sets and ANN to structure the evaluation audit Rough-ANN model, and then the paper explains an example to verify the feasibility and effectiveness of this model.

  2. 供应链风险的系统识别与评价模型研究%Study on Supply Chain Risk System Identification and Evaluation Model

    Institute of Scientific and Technical Information of China (English)

    耿殿明; 刘佳翔

    2011-01-01

    In this paper, we systematically identify and classify supply chain risks, as well as its controllability and harmfnl influence. A supply chain risk evaluation index system is formulated for the identification and classification of supply chain risks, and then through improved set-valued statistical accelerated iteration method, the weight of each index is determined. On the basis of expert risk probability interval estimation, a comprehensive evaluation model for supply chain risk is constructed and an empirical analysis is carried out at the last.%对供应链风险进行了系统识别和分类,分析了供应链风险的可控性和危害性.构建了供应链风险评估指标体系,利用改进的集值统计加速迭代法确定各指标权重,建立了基于专家风险概率区间估计的供应链风险综合评价模型,并进行了实证分析.

  3. Software Platform Evaluation - Verifiable Fuel Cycle Simulation (VISION) Model

    Energy Technology Data Exchange (ETDEWEB)

    J. J. Jacobson; D. E. Shropshire; W. B. West

    2005-11-01

    The purpose of this Software Platform Evaluation (SPE) is to document the top-level evaluation of potential software platforms on which to construct a simulation model that satisfies the requirements for a Verifiable Fuel Cycle Simulation Model (VISION) of the Advanced Fuel Cycle (AFC). See the Software Requirements Specification for Verifiable Fuel Cycle Simulation (VISION) Model (INEEL/EXT-05-02643, Rev. 0) for a discussion of the objective and scope of the VISION model. VISION is intended to serve as a broad systems analysis and study tool applicable to work conducted as part of the AFCI (including costs estimates) and Generation IV reactor development studies. This document will serve as a guide for selecting the most appropriate software platform for VISION. This is a “living document” that will be modified over the course of the execution of this work.

  4. Structural equation modeling: building and evaluating causal models: Chapter 8

    Science.gov (United States)

    Grace, James B.; Scheiner, Samuel M.; Schoolmaster, Donald R.

    2015-01-01

    Scientists frequently wish to study hypotheses about causal relationships, rather than just statistical associations. This chapter addresses the question of how scientists might approach this ambitious task. Here we describe structural equation modeling (SEM), a general modeling framework for the study of causal hypotheses. Our goals are to (a) concisely describe the methodology, (b) illustrate its utility for investigating ecological systems, and (c) provide guidance for its application. Throughout our presentation, we rely on a study of the effects of human activities on wetland ecosystems to make our description of methodology more tangible. We begin by presenting the fundamental principles of SEM, including both its distinguishing characteristics and the requirements for modeling hypotheses about causal networks. We then illustrate SEM procedures and offer guidelines for conducting SEM analyses. Our focus in this presentation is on basic modeling objectives and core techniques. Pointers to additional modeling options are also given.

  5. Finds in Testing Experiments for Model Evaluation

    Institute of Scientific and Technical Information of China (English)

    WU Ji; JIA Xiaoxia; LIU Chang; YANG Haiyan; LIU Chao

    2005-01-01

    To evaluate the fault location and the failure prediction models, simulation-based and code-based experiments were conducted to collect the required failure data. The PIE model was applied to simulate failures in the simulation-based experiment. Based on syntax and semantic level fault injections, a hybrid fault injection model is presented. To analyze the injected faults, the difficulty to inject (DTI) and difficulty to detect (DTD) are introduced and are measured from the programs used in the code-based experiment. Three interesting results were obtained from the experiments: 1) Failures simulated by the PIE model without consideration of the program and testing features are unreliably predicted; 2) There is no obvious correlation between the DTI and DTD parameters; 3) The DTD for syntax level faults changes in a different pattern to that for semantic level faults when the DTI increases. The results show that the parameters have a strong effect on the failures simulated, and the measurement of DTD is not strict.

  6. CTBT Integrated Verification System Evaluation Model

    Energy Technology Data Exchange (ETDEWEB)

    Edenburn, M.W.; Bunting, M.L.; Payne, A.C. Jr.

    1997-10-01

    Sandia National Laboratories has developed a computer based model called IVSEM (Integrated Verification System Evaluation Model) to estimate the performance of a nuclear detonation monitoring system. The IVSEM project was initiated in June 1994, by Sandia`s Monitoring Systems and Technology Center and has been funded by the US Department of Energy`s Office of Nonproliferation and National Security (DOE/NN). IVSEM is a simple, top-level, modeling tool which estimates the performance of a Comprehensive Nuclear Test Ban Treaty (CTBT) monitoring system and can help explore the impact of various sensor system concepts and technology advancements on CTBT monitoring. One of IVSEM`s unique features is that it integrates results from the various CTBT sensor technologies (seismic, infrasound, radionuclide, and hydroacoustic) and allows the user to investigate synergy among the technologies. Specifically, IVSEM estimates the detection effectiveness (probability of detection) and location accuracy of the integrated system and of each technology subsystem individually. The model attempts to accurately estimate the monitoring system`s performance at medium interfaces (air-land, air-water) and for some evasive testing methods such as seismic decoupling. This report describes version 1.2 of IVSEM.

  7. Single-dose safety and pharmacokinetic evaluation of fluorocoxib A: pilot study of novel cyclooxygenase-2-targeted optical imaging agent in a canine model

    OpenAIRE

    Cekanova, Maria; Uddin, Md. Jashim; Legendre, Alfred M.; Galyon, Gina; Bartges, Joseph W.; Callens, Amanda; Martin-Jimenez, Tomas; Marnett, Lawrence J.

    2012-01-01

    We evaluated preclinical single-dose safety, pharmacokinetic properties, and specific uptake of the new optical imaging agent fluorocoxib A in dogs. Fluorocoxib A, N-[(5-carboxy-X-rhodaminyl)but-4-yl]-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamide, selectively binds and inhibits the cyclooxygenase-2 (COX-2) enzyme, which is overexpressed in many cancers. Safety pilot studies were performed in research dogs following intravenous (i.v.) administration of 0.1 and 1  mg/kg fluo...

  8. Developing a Performance Evaluation Model of Trustees Boards in Iranian Universities of Medical Sciences

    Directory of Open Access Journals (Sweden)

    Haniye Sadat Sajadi

    2015-05-01

    Full Text Available The critical role of the boards of trustee in the governance of universities clarifies the necessity of evaluating its performance. Despite the importance of such evaluation, evidence demonstrated few studies have been done on the model of board performance evaluation especially in Iran. Aim: This study was aimed to develop a model to evaluate the board performance in Iranian Universities of Medical Sciences. Methodology: The present study was a mix qualitative-quantitative study. The participants were all stakeholders of board performance evaluation. The study, firstly, focused on the world experiences about the models of the board performance evaluation in the universities. Then, this study tried to investigate the current and proposed model of the board performance evaluation in the Iranian Universities of Medical Sciences. Hence, data were collected through interviews, observation and relevant document analysis and analyzed using framework approach. After that, the clustering and rating of the proposed dimensions and indicators of the board performance evaluation was done using the concept mapping method. Finally, the study concentrated on the expert consensus about the initial proposed model of the board performance evaluation. A model was proposed to evaluate the board performance in Iranian Universities of Medical Sciences, which had eight parts and sixty-four indicators proposing for the board performance evaluation. This study helped to develop a valid model to evaluate the board performance evaluation in a special kind of university. Such model can be used to produce useful tool for evaluating the performance of the board.

  9. An evaluation framework for participatory modelling

    Science.gov (United States)

    Krueger, T.; Inman, A.; Chilvers, J.

    2012-04-01

    Strong arguments for participatory modelling in hydrology can be made on substantive, instrumental and normative grounds. These arguments have led to increasingly diverse groups of stakeholders (here anyone affecting or affected by an issue) getting involved in hydrological research and the management of water resources. In fact, participation has become a requirement of many research grants, programs, plans and policies. However, evidence of beneficial outcomes of participation as suggested by the arguments is difficult to generate and therefore rare. This is because outcomes are diverse, distributed, often tacit, and take time to emerge. In this paper we develop an evaluation framework for participatory modelling focussed on learning outcomes. Learning encompasses many of the potential benefits of participation, such as better models through diversity of knowledge and scrutiny, stakeholder empowerment, greater trust in models and ownership of subsequent decisions, individual moral development, reflexivity, relationships, social capital, institutional change, resilience and sustainability. Based on the theories of experiential, transformative and social learning, complemented by practitioner experience our framework examines if, when and how learning has occurred. Special emphasis is placed on the role of models as learning catalysts. We map the distribution of learning between stakeholders, scientists (as a subgroup of stakeholders) and models. And we analyse what type of learning has occurred: instrumental learning (broadly cognitive enhancement) and/or communicative learning (change in interpreting meanings, intentions and values associated with actions and activities; group dynamics). We demonstrate how our framework can be translated into a questionnaire-based survey conducted with stakeholders and scientists at key stages of the participatory process, and show preliminary insights from applying the framework within a rural pollution management situation in

  10. A standard telemental health evaluation model: the time is now.

    Science.gov (United States)

    Kramer, Greg M; Shore, Jay H; Mishkind, Matt C; Friedl, Karl E; Poropatich, Ronald K; Gahm, Gregory A

    2012-05-01

    The telehealth field has advanced historic promises to improve access, cost, and quality of care. However, the extent to which it is delivering on its promises is unclear as the scientific evidence needed to justify success is still emerging. Many have identified the need to advance the scientific knowledge base to better quantify success. One method for advancing that knowledge base is a standard telemental health evaluation model. Telemental health is defined here as the provision of mental health services using live, interactive video-teleconferencing technology. Evaluation in the telemental health field largely consists of descriptive and small pilot studies, is often defined by the individual goals of the specific programs, and is typically focused on only one outcome. The field should adopt new evaluation methods that consider the co-adaptive interaction between users (patients and providers), healthcare costs and savings, and the rapid evolution in communication technologies. Acceptance of a standard evaluation model will improve perceptions of telemental health as an established field, promote development of a sounder empirical base, promote interagency collaboration, and provide a framework for more multidisciplinary research that integrates measuring the impact of the technology and the overall healthcare aspect. We suggest that consideration of a standard model is timely given where telemental health is at in terms of its stage of scientific progress. We will broadly recommend some elements of what such a standard evaluation model might include for telemental health and suggest a way forward for adopting such a model.

  11. Further Evaluation of a Brief, Intensive Teacher-Training Model

    Science.gov (United States)

    Lerman, Dorothea C.; Tetreault, Allison; Hovanetz, Alyson; Strobel, Margaret; Garro, Joanie

    2008-01-01

    The purpose of this study was to further evaluate the outcomes of a model program that was designed to train current teachers of children with autism. Nine certified special education teachers participating in an intensive 5-day summer training program were taught a relatively large number of specific skills in two areas (preference assessment and…

  12. Designing and evaluating representations to model pedagogy

    Directory of Open Access Journals (Sweden)

    Elizabeth Masterman

    2013-08-01

    Full Text Available This article presents the case for a theory-informed approach to designing and evaluating representations for implementation in digital tools to support Learning Design, using the framework of epistemic efficacy as an example. This framework, which is rooted in the literature of cognitive psychology, is operationalised through dimensions of fit that attend to: (1 the underlying ontology of the domain, (2 the purpose of the task that the representation is intended to facilitate, (3 how best to support the cognitive processes of the users of the representations, (4 users’ differing needs and preferences, and (5 the tool and environment in which the representations are constructed and manipulated.Through showing how epistemic efficacy can be applied to the design and evaluation of representations, the article presents the Learning Designer, a constructionist microworld in which teachers can both assemble their learning designs and model their pedagogy in terms of students’ potential learning experience. Although the activity of modelling may add to the cognitive task of design, the article suggests that the insights thereby gained can additionally help a lecturer who wishes to reuse a particular learning design to make informed decisions about its value to their practice.

  13. Popularity Evaluation Model for Microbloggers Online Social Network

    Directory of Open Access Journals (Sweden)

    Xia Zhang

    2014-01-01

    Full Text Available Recently, microblogging is widely studied by the researchers in the domain of the online social network (OSN. How to evaluate the popularities of microblogging users is an important research field, which can be applied to commercial advertising, user behavior analysis and information dissemination, and so forth. Previous studies on the evaluation methods cannot effectively solve and accurately evaluate the popularities of the microbloggers. In this paper, we proposed an electromagnetic field theory based model to analyze the popularities of microbloggers. The concept of the source in microblogging field is first put forward, which is based on the concept of source in the electromagnetic field; then, one’s microblogging flux is calculated according to his/her behaviors (send or receive feedbacks on the microblogging platform; finally, we used three methods to calculate one’s microblogging flux density, which can represent one’s popularity on the microblogging platform. In the experimental work, we evaluated our model using real microblogging data and selected the best one from the three popularity measure methods. We also compared our model with the classic PageRank algorithm; and the results show that our model is more effective and accurate to evaluate the popularities of the microbloggers.

  14. Efficacy and tolerability studies evaluating a sleep aid and analgesic combination of naproxen sodium and diphenhydramine in the dental impaction pain model in subjects with induced transient insomnia.

    Science.gov (United States)

    Cooper, S; Laurora, I; Wang, Y; Venkataraman, P; An, R; Roth, T

    2015-10-01

    The aim of this study was to evaluate the efficacy and tolerability of novel combination naproxen sodium (NS) and diphenhydramine (DPH) in subjects with postoperative dental pain along with transient insomnia induced by 5 h sleep phase advance. The present studies aimed to demonstrate the added benefit and optimal dosages of the combination product over individual ingredients alone in improving sleep and pain. Each of the two studies was a two-centre, randomised, double-blind and double-dummy trial. In the first study, subjects were randomised into one of the following treatment arms: NS 440 mg/DPH 50 mg, NS 220 mg/DPH 50 mg, NS 440 mg or DPH 50 mg. In the second study, subjects received either NS 440 mg/DPH 25 mg, NS 440 mg or DPH 50 mg. The co-primary end-points in both studies were wake time after sleep onset (WASO) and sleep latency (SL) measured by actigraphy. Other secondary sleep and pain end-points were also assessed. The intent-to-treat population included 712 and 267 subjects from studies one and two, respectively. In the first study, only the NS 440 mg/DPH 50 mg combination showed significant improvements in both WASO vs. NS alone (-70.3 min p = 0.0002) and SL vs. DPH alone (25.50 and 41.50 min respectively, p sleep latency vs. DPH 50 mg and sleep maintenance (WASO) vs. NS 440 mg. There were no serious or unexpected adverse events reported in either study. NCT01280591 (study 1); NCT01495858 (study 2). © 2015 The Authors. International Journal of Clinical Practice Published by John Wiley & Sons Ltd.

  15. Comprehensive Evaluation Cloud Model for Ship Navigation Adaptability

    OpenAIRE

    Man Zhu; Y.Q. Wen; Zhou, C. H.; C.S. Xiao

    2014-01-01

    In this paper, using cloud model and Delphi, we build a comprehensive evaluation cloud model to solve the problems of qualitative description and quantitative transformation in ship navigation adaptability comprehensive evaluation. In the model, the normal cloud generator is used to find optimal cloud models of reviews and evaluation factors. The weight of each evaluation factor is determined by cloud model and Delphi. The floating cloud algorithm is applied to aggregate the bottom level’s ev...

  16. Vestibular models for design and evaluation of flight simulator motion

    Science.gov (United States)

    Bussolari, S. R.; Sullivan, R. B.; Young, L. R.

    1986-01-01

    The use of spatial orientation models in the design and evaluation of control systems for motion-base flight simulators is investigated experimentally. The development of a high-fidelity motion drive controller using an optimal control approach based on human vestibular models is described. The formulation and implementation of the optimal washout system are discussed. The effectiveness of the motion washout system was evaluated by studying the response of six motion washout systems to the NASA/AMES Vertical Motion Simulator for a single dash-quick-stop maneuver. The effects of the motion washout system on pilot performance and simulator acceptability are examined. The data reveal that human spatial orientation models are useful for the design and evaluation of flight simulator motion fidelity.

  17. MODELLING AND EVALUATION OF OPERATIONAL COMPETITIVENESS OF MANUFACTURING ENTERPRISES

    Directory of Open Access Journals (Sweden)

    YANG LIU

    2009-12-01

    Full Text Available This paper is aiming to connect previous research in global competitiveness analysis. Research is based on doing numerous case studies and creating analytical models to evaluate the overall competitiveness, which is a novel concept by integrating the evaluation of manufacturing strategy and transformational leadership including technology level together. The empirical studies are focused to case companies in China especially Chinese State-Owned Manufacturing Enterprise (CSOME. The main emphasises of this research are manufacturing strategy and transformational leadership for CSOME. We have brought the influence of “China effect” to study how it will impact the operational competitiveness of CSOME on top of their manufacturing strategy and transformational leadership.

  18. Evaluation of Rainfall-Runoff Models for Mediterranean Subcatchments

    Science.gov (United States)

    Cilek, A.; Berberoglu, S.; Donmez, C.

    2016-06-01

    The development and the application of rainfall-runoff models have been a corner-stone of hydrological research for many decades. The amount of rainfall and its intensity and variability control the generation of runoff and the erosional processes operating at different scales. These interactions can be greatly variable in Mediterranean catchments with marked hydrological fluctuations. The aim of the study was to evaluate the performance of rainfall-runoff model, for rainfall-runoff simulation in a Mediterranean subcatchment. The Pan-European Soil Erosion Risk Assessment (PESERA), a simplified hydrological process-based approach, was used in this study to combine hydrological surface runoff factors. In total 128 input layers derived from data set includes; climate, topography, land use, crop type, planting date, and soil characteristics, are required to run the model. Initial ground cover was estimated from the Landsat ETM data provided by ESA. This hydrological model was evaluated in terms of their performance in Goksu River Watershed, Turkey. It is located at the Central Eastern Mediterranean Basin of Turkey. The area is approximately 2000 km2. The landscape is dominated by bare ground, agricultural and forests. The average annual rainfall is 636.4mm. This study has a significant importance to evaluate different model performances in a complex Mediterranean basin. The results provided comprehensive insight including advantages and limitations of modelling approaches in the Mediterranean environment.

  19. EVALUATION OF RAINFALL-RUNOFF MODELS FOR MEDITERRANEAN SUBCATCHMENTS

    Directory of Open Access Journals (Sweden)

    A. Cilek

    2016-06-01

    Full Text Available The development and the application of rainfall-runoff models have been a corner-stone of hydrological research for many decades. The amount of rainfall and its intensity and variability control the generation of runoff and the erosional processes operating at different scales. These interactions can be greatly variable in Mediterranean catchments with marked hydrological fluctuations. The aim of the study was to evaluate the performance of rainfall-runoff model, for rainfall-runoff simulation in a Mediterranean subcatchment. The Pan-European Soil Erosion Risk Assessment (PESERA, a simplified hydrological process-based approach, was used in this study to combine hydrological surface runoff factors. In total 128 input layers derived from data set includes; climate, topography, land use, crop type, planting date, and soil characteristics, are required to run the model. Initial ground cover was estimated from the Landsat ETM data provided by ESA. This hydrological model was evaluated in terms of their performance in Goksu River Watershed, Turkey. It is located at the Central Eastern Mediterranean Basin of Turkey. The area is approximately 2000 km2. The landscape is dominated by bare ground, agricultural and forests. The average annual rainfall is 636.4mm. This study has a significant importance to evaluate different model performances in a complex Mediterranean basin. The results provided comprehensive insight including advantages and limitations of modelling approaches in the Mediterranean environment.

  20. Evaluating Evaluation Systems: Policy Levers and Strategies for Studying Implementation of Educator Evaluation. Policy Snapshot

    Science.gov (United States)

    Matlach, Lauren

    2015-01-01

    Evaluation studies can provide feedback on implementation, support continuous improvement, and increase understanding of evaluation systems' impact on teaching and learning. Despite the importance of educator evaluation studies, states often need support to prioritize and fund them. Successful studies require expertise, time, and a shared…

  1. Evaluation of multivariate calibration models transferred between spectroscopic instruments

    DEFF Research Database (Denmark)

    Eskildsen, Carl Emil Aae; Hansen, Per W.; Skov, Thomas

    2016-01-01

    In a setting where multiple spectroscopic instruments are used for the same measurements it may be convenient to develop the calibration model on a single instrument and then transfer this model to the other instruments. In the ideal scenario, all instruments provide the same predictions for the ......In a setting where multiple spectroscopic instruments are used for the same measurements it may be convenient to develop the calibration model on a single instrument and then transfer this model to the other instruments. In the ideal scenario, all instruments provide the same predictions...... for the same samples using the transferred model. However, sometimes the success of a model transfer is evaluated by comparing the transferred model predictions with the reference values. This is not optimal, as uncertainties in the reference method will impact the evaluation. This paper proposes a new method...... for calibration model transfer evaluation. The new method is based on comparing predictions from different instruments, rather than comparing predictions and reference values. A total of 75 flour samples were available for the study. All samples were measured on ten near infrared (NIR) instruments from two...

  2. Research and application of a hybrid model based on dynamic fuzzy synthetic evaluation for establishing air quality forecasting and early warning system: A case study in China.

    Science.gov (United States)

    Xu, Yunzhen; Du, Pei; Wang, Jianzhou

    2017-04-01

    As the atmospheric environment pollution has been becoming more and more serious in China, it is highly desirable to develop a scientific and effective early warning system that plays a great significant role in analyzing and monitoring air quality. However, establishing a robust early warning system for warning the public in advance and ameliorating air quality is not only an extremely challenging task but also a public concerned problem for human health. Most previous studies are focused on improving the prediction accuracy, which usually ignore the significance of uncertainty information and comprehensive evaluation concerning air pollutants. Therefore, in this paper a novel robust early warning system was successfully developed, which consists of three modules: evaluation module, forecasting module and characteristics estimating module. In this system, a new dynamic fuzzy synthetic evaluation is proposed and applied to determine air quality levels and primary pollutants, which can be regarded as the research objectives; Moreover, to further mine and analyze the characteristics of air pollutants, four different distribution functions and interval forecasting method are also employed that can not only provide predictive range, confidence level and the other uncertain information of the pollutants future values, but also assist decision-makers in reducing and controlling the emissions of atmospheric pollutants. Case studies utilizing hourly PM2.5, PM10 and SO2 data collected from Tianjin and Shanghai in China are applied as illustrative examples to estimate the effectiveness and efficiency of the proposed system. Experimental results obviously indicated that the developed novel early warning system is much suitable for analyzing and monitoring air pollution, which can also add a novel viable option for decision-makers. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. A Systematic Evaluation Model for Solar Cell Technologies

    Directory of Open Access Journals (Sweden)

    Chang-Fu Hsu

    2014-01-01

    Full Text Available Fossil fuels, including coal, petroleum, natural gas, and nuclear energy, are the primary electricity sources currently. However, with depletion of fossil fuels, global warming, nuclear crisis, and increasing environmental consciousness, the demand for renewable energy resources has skyrocketed. Solar energy is one of the most popular renewable energy resources for meeting global energy demands. Even though there are abundant studies on various solar technology developments, there is a lack of studies on solar technology evaluation and selection. Therefore, this research develops a model using interpretive structural modeling (ISM, benefits, opportunities, costs, and risks concept (BOCR, and fuzzy analytic network process (FANP to aggregate experts' opinions in evaluating current available solar cell technology. A case study in a photovoltaics (PV firm is used to examine the practicality of the proposed model in selecting the most suitable technology for the firm in manufacturing new products.

  4. Evaluation of some infiltration models and hydraulic parameters

    Energy Technology Data Exchange (ETDEWEB)

    Haghighi, F.; Gorji, M.; Shorafa, M.; Sarmadian, F.; Mohammadi, M. H.

    2010-07-01

    The evaluation of infiltration characteristics and some parameters of infiltration models such as sorptivity and final steady infiltration rate in soils are important in agriculture. The aim of this study was to evaluate some of the most common models used to estimate final soil infiltration rate. The equality of final infiltration rate with saturated hydraulic conductivity (Ks) was also tested. Moreover, values of the estimated sorptivity from the Philips model were compared to estimates by selected pedotransfer functions (PTFs). The infiltration experiments used the doublering method on soils with two different land uses in the Taleghan watershed of Tehran province, Iran, from September to October, 2007. The infiltration models of Kostiakov-Lewis, Philip two-term and Horton were fitted to observed infiltration data. Some parameters of the models and the coefficient of determination goodness of fit were estimated using MATLAB software. The results showed that, based on comparing measured and model-estimated infiltration rate using root mean squared error (RMSE), Hortons model gave the best prediction of final infiltration rate in the experimental area. Laboratory measured Ks values gave significant differences and higher values than estimated final infiltration rates from the selected models. The estimated final infiltration rate was not equal to laboratory measured Ks values in the study area. Moreover, the estimated sorptivity factor by Philips model was significantly different to those estimated by selected PTFs. It is suggested that the applicability of PTFs is limited to specific, similar conditions. (Author) 37 refs.

  5. Bioadhesive agents in addition to oral contrast media - evaluation in an animal model; Evaluierung der Wirkung bioadhaesiver Substanzen als Zugabe zu oralen Kontrastmitteln - eine experimentelle Studie

    Energy Technology Data Exchange (ETDEWEB)

    Conrad, R.; Schneider, G.; Textor, J.; Schild, H.H. [Radiologische Universitaetsklinik Bonn (Germany); Fimmers, R. [Universitaetsklinik Bonn (Germany). Inst. fuer Medizinische Statistik und Datenverarbeitung; Sachse, A. [Schering AG, Berlin (Germany)

    1998-06-01

    Purpose: To evaluate the additional effect of bioadhesives in combination with iotrolan and barium as oral contrast media in an animal model. Method: The bioadhesives Noveon, CMC, Tylose and Carbopol 934 were added to iotrolan and barium. The solutions were administered to rabbits by a feeding tube. The animals were investigated by computed tomography (CT) and radiography after 0,5, 4, 12, 24 and in part after 48 hours. Mucosal coating and contrast filling of the bowel were evaluated. Results: Addition of bioadhesives to oral contrast media effected long-term contrast in the small intestine and colon, but no improvement in continuous filling and coating of the gastrointestinal tract was detected. Mucosal coating was seen only in short regions of the caecum and small intestine. In CT the best results for coating were observed with tylose and CMC, in radiography additionally with carbopol and noveon. All contrast medium solutions were well tolerated. Conclusion: The evaluated contrast medium solutions with bioadhesives have shown long-term contrast but no improvement in coating in comparison to conventional oral contrast media. (orig.) [Deutsch] Ziel: Pruefung der Wirkung von bioadhaesiven Substanzen als Zugabe zu den oralen Kontrastmitteln (KM) Iotrolan und Barium im Tierexperiment. Methode: Die bioadhaesiven Substanzen Noveon, Carboxymethylcellulose (CMC), Tylose und Carbopol 934 wurden Iotrolan-Loesungen und Bariumsulfatsuspensionen beigemischt und anschliessend 30 Kaninchen ueber Magensonde verabreicht. In der Spiral-CT und Radiographie wurden die Tiere nach 0,5, 4, 12, 24 und teilweise nach 48 Stunden untersucht und hinsichtlich Schleimhautbeschlag und kontinuierlicher KM-Fuellung bewertet. Ergebnisse: Die Zugabe adhaesiver Stubstanzen beguenstigte eine langanhaltende Kontrastierung von Duenn- und Dickdarm. Es konnte jedoch weder eine vollstaendige Kontrastierung noch ein durchgehender Beschlag des gesamten Gastrointestinaltraktes bewirkt werden. Ein

  6. Evaluation of the usefulness of 2 prediction models of clinical prediction models in physical therapy: a qualitative process evaluation.

    NARCIS (Netherlands)

    Oort, L. van; Verhagen, A.F.; Koes, B.; Vet, R. de; Anema, H.; Heymans, M.

    2014-01-01

    OBJECTIVE: The purposes of this study were to (1) evaluate the usefulness of 2 prediction models by assessing the actual use and advantages/disadvantages of application in daily clinical practice and (2) propose recommendations to enhance their implementation. METHODS: Physical therapists working in

  7. Evaluating the Predictive Impact of an Emergent Literacy Model on Dyslexia in Italian Children: A Four-Year Prospective Cohort Study.

    Science.gov (United States)

    Bigozzi, Lucia; Tarchi, Christian; Pezzica, Sara; Pinto, Giuliana

    2016-01-01

    The strong differences in manifestation, prevalence, and incidence in dyslexia across languages invite studies in specific writing systems. In particular, the question of the role played by emergent literacy in opaque and transparent writing systems remains a fraught one. This research project tested, through a 4-year prospective cohort study, an emergent literacy model for the analysis of the characteristics of future dyslexic children and normally reading peers in Italian, a transparent writing system. A cohort of 450 children was followed from the last year of kindergarten to the third grade in their reading acquisition process. Dyslexic children were individuated (Grade 3), and their performances in kindergarten in textual competence, phonological awareness, and conceptual knowledge of the writing system were compared with a matched group of normally reading peers. Results showed the predictive relevance of the conceptual knowledge of the writing system. The study's implications are discussed.

  8. An Evaluation of the Preceptor Model versus the Formal Teaching Model.

    Science.gov (United States)

    Shamian, Judith; Lemieux, Suzanne

    1984-01-01

    This study evaluated the effectiveness of two teaching methods to determine which is more effective in enhancing the knowledge base of participating nurses: the preceptor model embodies decentralized instruction by a member of the nursing staff, and the formal teaching model uses centralized teaching by the inservice education department. (JOW)

  9. An Evaluation of the Preceptor Model versus the Formal Teaching Model.

    Science.gov (United States)

    Shamian, Judith; Lemieux, Suzanne

    1984-01-01

    This study evaluated the effectiveness of two teaching methods to determine which is more effective in enhancing the knowledge base of participating nurses: the preceptor model embodies decentralized instruction by a member of the nursing staff, and the formal teaching model uses centralized teaching by the inservice education department. (JOW)

  10. 联合后勤保障效能评价模型研究%Study on Efficacy Evaluation Model of Joint Logistical Support Operations

    Institute of Scientific and Technical Information of China (English)

    周庆忠; 田野; 熊彪

    2016-01-01

    为了解决分布动态联合后勤保障环境中多个保障决策者和保障实体处于“多对多”设定下协同交互,致使后勤保障受众多因素制约,调运计划生成难度加大这一问题,提出了基于Agent的联合后勤保障效能评价模型。从后勤保障军事和经济广义效能视角,对请领任务的保障实体,计算其保障调运效能,以便优化配置保障资源,为优化后勤保障调运计划提供量化决策依据。以联合作战后勤保障为仿真实例来验证模型的有效性,仿真结果表明该模型的研究对于快速实现联合后勤保障总体目标具有实际意义。%In this paper, in view of the problems existing in the dynamic joint logistical support environment, we proposed an agent-based joint logistical support efficacy evaluation model, from the perspective of military logistical support and general military utility, calculated the support scheduling efficacy of the task-demand support entities so as to optimize their resource allocation, and at the end, through a simulated example, demonstrated the practical significance of the model.

  11. Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies

    Energy Technology Data Exchange (ETDEWEB)

    Fujimoto, T., E-mail: fujitaku@hp.pref.hyogo.jp [Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-0021 (Japan); Andoh, T. [Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586 (Japan); Sudo, T. [Section of Translational Research, Hyogo Cancer Center, Akashi 673-0021 (Japan); Fujita, I.; Imabori, M. [Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-0021 (Japan); Moritake, H. [Division of Pediatrics, University of Miyazaki, Miyazaki 889-1692 (Japan); Sugimoto, T. [Department of Pediatrics, Saiseikai Shigaken Hospital, Ritto 520-3046 (Japan); Sakuma, Y. [Department of Pathology, Hyogo Cancer Center, Akashi 673-0021 (Japan); Takeuchi, T. [Department of Pathology, Kochi Medical School, Nangoku 783-8505 (Japan); Sonobe, H. [Department of Pathology, Chugoku Central Hospital, Fukuyama 720-0001 (Japan); Epstein, Alan L. [Department of Pathology, Keck School of Medicine,University of Southern California, Los Angeles,CA 90033 (United States); Akisue, T. [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Kirihata, M. [Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai 599-8531 (Japan); Kurosaka, M. [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Fukumori, Y.; Ichikawa, H. [Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586 (Japan)

    2011-12-15

    Clear cell sarcoma (CCS), a rare malignant tumor with a predilection for young adults, is of poor prognosis. Recently however, boron neutron capture therapy (BNCT) with the use of p-borono-L-phenylalanine (BPA) for malignant melanoma has provided good results. CCS also produces melanin; therefore, the uptake of BPA is the key to the application of BNCT to CCS. We describe, for the first time, the high accumulation of boron in CCS and the CCS tumor-bearing animal model generated for BNCT studies.

  12. Moisture evaluation by dynamic thermography data modeling

    Science.gov (United States)

    Bison, Paolo G.; Grinzato, Ermanno G.; Marinetti, Sergio

    1994-03-01

    This paper discusses the design of a nondestructive method for in situ detection of moistened areas in buildings and the evaluation of the water content in porous materials by thermographic analysis. The use of heat transfer model to interpret data allows to improve the measurement accuracy taking into account the actual boundary conditions. The relative increase of computation time is balanced by the additional advantage to optimize the testing procedure of different objects simulating the heat transfer. Experimental results on bricks used in building for restoration activities, are discussed. The water content measured in different hygrometric conditions is compared with known values. A correction on the absorptivity coefficient dependent on water content is introduced.

  13. Fuzzy Based Evaluation of Software Quality Using Quality Models and Goal Models

    Directory of Open Access Journals (Sweden)

    Arfan Mansoor

    2015-09-01

    Full Text Available Software quality requirements are essential part for the success of software development. Defined and guaranteed quality in software development requires identifying, refining, and predicting quality properties by appropriate means. Goal models of goal oriented requirements engineering (GORE and quality models are useful for modelling of functional goals as well as for quality goals. Once the goal models are obtained representing the functional requirements and integrated quality goals, there is need to evaluate each functional requirement arising from functional goals and quality requirement arising from quality goals. The process consist of two main parts. In first part, the goal models are used to evaluate functional goals. The leaf level goals are used to establish the evaluation criteria. Stakeholders are also involved to contribute their opinions about the importance of each goal (functional and/or quality goal. Stakeholder opinions are then converted into quantifiable numbers using triangle fuzzy numbers (TFN. After applying the defuzzification process on TFN, the scores (weights are obtained for each goal. In second part specific quality goals are identified, refined/tailored based on existing quality models and their evaluation is performed similarly using TFN and by applying defuzzification process. The two step process helps to evaluate each goal based on stakeholder opinions and to evaluate the impact of quality requirements. It also helps to evaluate the relationships among functional goals and quality goals. The process is described and applied on ’cyclecomputer’ case study.

  14. DNA barcodes and species distribution models evaluate threats of global climate changes to genetic diversity: a case study from Nanorana parkeri (Anura: Dicroglossidae).

    Science.gov (United States)

    Zhou, Wei-wei; Zhang, Bao-lin; Chen, Hong-man; Jin, Jie-qiong; Yang, Jun-xiao; Wang, Yun-yu; Jiang, Ke; Murphy, Robert W; Zhang, Ya-ping; Che, Jing

    2014-01-01

    Anthropogenic global climate changes are one of the greatest threats to biodiversity. Distribution modeling can predict the effects of climate changes and potentially their effects on genetic diversity. DNA barcoding quickly identifies patterns of genetic diversity. As a case study, we use DNA barcodes and distribution models to predict threats under climate changes in the frog Nanorana parkeri, which is endemic to the Qinghai-Tibetan Plateau. Barcoding identifies major lineages W and E. Lineage W has a single origin in a refugium and Lineage E derives from three refugia. All refugia locate in river valleys and each greatly contributes to the current level of intraspecific genetic diversity. Species distribution models suggest that global climate changes will greatly influence N. parkeri, especially in the level of genetic diversity, because two former refugia will fail to provide suitable habitat. Our pipeline provides a novel application of DNA barcoding and has important implications for the conservation of biodiversity in southern areas of the Qinghai-Tibetan Plateau.

  15. Assessment of the skin irritation potential of chemicals by using the SkinEthic reconstructed human epidermal model and the common skin irritation protocol evaluated in the ECVAM skin irritation validation study.

    Science.gov (United States)

    Kandárová, Helena; Liebsch, Manfred; Schmidt, Elisabeth; Genschow, Elke; Traue, Dieter; Spielmann, Horst; Meyer, Kirstin; Steinhoff, Claudia; Tornier, Carine; De Wever, Bart; Rosdy, Martin

    2006-08-01

    Currently, two reconstructed human skin models, EpiDerm and EPISKIN are being evaluated in an ECVAM skin irritation validation study. A common skin irritation protocol has been developed, differing only in minor technical details for the two models. A small-scale study, applying this common skin irritation protocol to the SkinEthic reconstructed human epidermis (RHE), was performed at ZEBET at the BfR, Berlin, Germany, to consider whether this protocol could be successfully transferred to another epidermal model. Twenty substances from Phase III of the ECVAM prevalidation study on skin irritation were tested with the SkinEthic RHE. After minor, model-specific adaptations for the SkinEthic RHE, almost identical results to those obtained with the EpiDerm and EPISKIN models were achieved. The overall accuracy of the method was more than 80%, indicating a reliable prediction of the skin irritation potential of the tested chemicals when compared to in vivo rabbit data. As a next step, inter laboratory reproducibility was assessed in a study conducted between ZEBET and the Department of Experimental Toxicology, Schering AG, Berlin, Germany. Six coded substances were tested in both laboratories, with three different batches of the SkinEthic model. The assay results showed good reproducibility and correct predictions of the skin irritation potential for all six test chemicals. The results obtained with the SkinEthic RHE and the common protocol were reproducible in both phases, and the overall outcome is very similar to that of earlier studies with the EPISKIN and EpiDerm models. Therefore, the SkinEthic skin irritation assay test protocol can now be evaluated in a formal "catch-up" validation study.

  16. ZATPAC: a model consortium evaluates teen programs.

    Science.gov (United States)

    Owen, Kathryn; Murphy, Dana; Parsons, Chris

    2009-09-01

    How do we advance the environmental literacy of young people, support the next generation of environmental stewards and increase the diversity of the leadership of zoos and aquariums? We believe it is through ongoing evaluation of zoo and aquarium teen programming and have founded a consortium to pursue those goals. The Zoo and Aquarium Teen Program Assessment Consortium (ZATPAC) is an initiative by six of the nation's leading zoos and aquariums to strengthen institutional evaluation capacity, model a collaborative approach toward assessing the impact of youth programs, and bring additional rigor to evaluation efforts within the field of informal science education. Since its beginning in 2004, ZATPAC has researched, developed, pilot-tested and implemented a pre-post program survey instrument designed to assess teens' knowledge of environmental issues, skills and abilities to take conservation actions, self-efficacy in environmental actions, and engagement in environmentally responsible behaviors. Findings from this survey indicate that teens who join zoo/aquarium programs are already actively engaged in many conservation behaviors. After participating in the programs, teens showed a statistically significant increase in their reported knowledge of conservation and environmental issues and their abilities to research, explain, and find resources to take action on conservation issues of personal concern. Teens also showed statistically significant increases pre-program to post-program for various conservation behaviors, including "I talk with my family and/or friends about things they can do to help the animals or the environment," "I save water...," "I save energy...," "When I am shopping I look for recycled products," and "I help with projects that restore wildlife habitat."

  17. Application of Multiple Evaluation Models in Brazil

    Directory of Open Access Journals (Sweden)

    Rafael Victal Saliba

    2008-07-01

    Full Text Available Based on two different samples, this article tests the performance of a number of Value Drivers commonly used for evaluating companies by finance practitioners, through simple regression models of cross-section type which estimate the parameters associated to each Value Driver, denominated Market Multiples. We are able to diagnose the behavior of several multiples in the period 1994-2004, with an outlook also on the particularities of the economic activities performed by the sample companies (and their impacts on the performance through a subsequent analysis with segregation of companies in the sample by sectors. Extrapolating simple multiples evaluation standards from analysts of the main financial institutions in Brazil, we find that adjusting the ratio formulation to allow for an intercept does not provide satisfactory results in terms of pricing errors reduction. Results found, in spite of evidencing certain relative and absolute superiority among the multiples, may not be generically representative, given samples limitation.

  18. RTMOD: Real-Time MODel evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Graziani, G; Galmarini, S. [Joint Research centre, Ispra (Italy); Mikkelsen, T. [Risoe National Lab., Wind Energy and Atmospheric Physics Dept. (Denmark)

    2000-01-01

    The 1998 - 1999 RTMOD project is a system based on an automated statistical evaluation for the inter-comparison of real-time forecasts produced by long-range atmospheric dispersion models for national nuclear emergency predictions of cross-boundary consequences. The background of RTMOD was the 1994 ETEX project that involved about 50 models run in several Institutes around the world to simulate two real tracer releases involving a large part of the European territory. In the preliminary phase of ETEX, three dry runs (i.e. simulations in real-time of fictitious releases) were carried out. At that time, the World Wide Web was not available to all the exercise participants, and plume predictions were therefore submitted to JRC-Ispra by fax and regular mail for subsequent processing. The rapid development of the World Wide Web in the second half of the nineties, together with the experience gained during the ETEX exercises suggested the development of this project. RTMOD featured a web-based user-friendly interface for data submission and an interactive program module for displaying, intercomparison and analysis of the forecasts. RTMOD has focussed on model intercomparison of concentration predictions at the nodes of a regular grid with 0.5 degrees of resolution both in latitude and in longitude, the domain grid extending from 5W to 40E and 40N to 65N. Hypothetical releases were notified around the world to the 28 model forecasters via the web on a one-day warning in advance. They then accessed the RTMOD web page for detailed information on the actual release, and as soon as possible they then uploaded their predictions to the RTMOD server and could soon after start their inter-comparison analysis with other modelers. When additional forecast data arrived, already existing statistical results would be recalculated to include the influence by all available predictions. The new web-based RTMOD concept has proven useful as a practical decision-making tool for realtime

  19. [Establishment and evaluation of animal model with methamphetamine poisoning].

    Science.gov (United States)

    Xu, Jing; Zhou, Xiao-Li; Zhang, Hao; Deng, Chong; Zhang, Yan; Li, Zhen

    2009-08-01

    Amphetamine-type stimulants (ATS) is the most widespread narcotics in the 21st century. The methamphetamine's intoxication mechanism, psychological dependence, drug resistance and therapeutic drug development are the hot spots in current research. Establishment of animal model with methamphetamine poisoning is the basic for the relative studies, the normalization and standardization of the animal model settles the foundation for methamphetamine's further research. This article reviews the animal model of methamphetamine poisoning in China and abroad, the brief history of the acute, subacute and chronic animal model of methamphetamine poisoning, as well as the principles and methods of the animal model establishment and its evaluation criteria. The necessity, significance and its scientific expansion of performing experimental research on the methamphetamine poisoning animal model are also discussed.

  20. Road network safety evaluation using Bayesian hierarchical joint model.

    Science.gov (United States)

    Wang, Jie; Huang, Helai

    2016-05-01

    Safety and efficiency are commonly regarded as two significant performance indicators of transportation systems. In practice, road network planning has focused on road capacity and transport efficiency whereas the safety level of a road network has received little attention in the planning stage. This study develops a Bayesian hierarchical joint model for road network safety evaluation to help planners take traffic safety into account when planning a road network. The proposed model establishes relationships between road network risk and micro-level variables related to road entities and traffic volume, as well as socioeconomic, trip generation and network density variables at macro level which are generally used for long term transportation plans. In addition, network spatial correlation between intersections and their connected road segments is also considered in the model. A road network is elaborately selected in order to compare the proposed hierarchical joint model with a previous joint model and a negative binomial model. According to the results of the model comparison, the hierarchical joint model outperforms the joint model and negative binomial model in terms of the goodness-of-fit and predictive performance, which indicates the reasonableness of considering the hierarchical data structure in crash prediction and analysis. Moreover, both random effects at the TAZ level and the spatial correlation between intersections and their adjacent segments are found to be significant, supporting the employment of the hierarchical joint model as an alternative in road-network-level safety modeling as well.

  1. Rainwater harvesting: model-based design evaluation.

    Science.gov (United States)

    Ward, S; Memon, F A; Butler, D

    2010-01-01

    The rate of uptake of rainwater harvesting (RWH) in the UK has been slow to date, but is expected to gain momentum in the near future. The designs of two different new-build rainwater harvesting systems, based on simple methods, are evaluated using three different design methods, including a continuous simulation modelling approach. The RWH systems are shown to fulfill 36% and 46% of WC demand. Financial analyses reveal that RWH systems within large commercial buildings maybe more financially viable than smaller domestic systems. It is identified that design methods based on simple approaches generate tank sizes substantially larger than the continuous simulation. Comparison of the actual tank sizes and those calculated using continuous simulation established that the tanks installed are oversized for their associated demand level and catchment size. Oversizing tanks can lead to excessive system capital costs, which currently hinders the uptake of systems. Furthermore, it is demonstrated that the catchment area size is often overlooked when designing UK-based RWH systems. With respect to these findings, a recommendation for a transition from the use of simple tools to continuous simulation models is made.

  2. Evaluation of clinical information modeling tools.

    Science.gov (United States)

    Moreno-Conde, Alberto; Austin, Tony; Moreno-Conde, Jesús; Parra-Calderón, Carlos L; Kalra, Dipak

    2016-11-01

    Clinical information models are formal specifications for representing the structure and semantics of the clinical content within electronic health record systems. This research aims to define, test, and validate evaluation metrics for software tools designed to support the processes associated with the definition, management, and implementation of these models. The proposed framework builds on previous research that focused on obtaining agreement on the essential requirements in this area. A set of 50 conformance criteria were defined based on the 20 functional requirements agreed by that consensus and applied to evaluate the currently available tools. Of the 11 initiative developing tools for clinical information modeling identified, 9 were evaluated according to their performance on the evaluation metrics. Results show that functionalities related to management of data types, specifications, metadata, and terminology or ontology bindings have a good level of adoption. Improvements can be made in other areas focused on information modeling and associated processes. Other criteria related to displaying semantic relationships between concepts and communication with terminology servers had low levels of adoption. The proposed evaluation metrics were successfully tested and validated against a representative sample of existing tools. The results identify the need to improve tool support for information modeling and software development processes, especially in those areas related to governance, clinician involvement, and optimizing the technical validation of testing processes. This research confirmed the potential of these evaluation metrics to support decision makers in identifying the most appropriate tool for their organization. Los Modelos de Información Clínica son especificaciones para representar la estructura y características semánticas del contenido clínico en los sistemas de Historia Clínica Electrónica. Esta investigación define, prueba y valida

  3. COMPUTER MODEL FOR ORGANIC FERTILIZER EVALUATION

    Directory of Open Access Journals (Sweden)

    Zdenko Lončarić

    2009-12-01

    Full Text Available Evaluation of manures, composts and growing media quality should include enough properties to enable an optimal use from productivity and environmental points of view. The aim of this paper is to describe basic structure of organic fertilizer (and growing media evaluation model to present the model example by comparison of different manures as well as example of using plant growth experiment for calculating impact of pH and EC of growing media on lettuce plant growth. The basic structure of the model includes selection of quality indicators, interpretations of indicators value, and integration of interpreted values into new indexes. The first step includes data input and selection of available data as a basic or additional indicators depending on possible use as fertilizer or growing media. The second part of the model uses inputs for calculation of derived quality indicators. The third step integrates values into three new indexes: fertilizer, growing media, and environmental index. All three indexes are calculated on the basis of three different groups of indicators: basic value indicators, additional value indicators and limiting factors. The possible range of indexes values is 0-10, where range 0-3 means low, 3-7 medium and 7-10 high quality. Comparing fresh and composted manures, higher fertilizer and environmental indexes were determined for composted manures, and the highest fertilizer index was determined for composted pig manure (9.6 whereas the lowest for fresh cattle manure (3.2. Composted manures had high environmental index (6.0-10 for conventional agriculture, but some had no value (environmental index = 0 for organic agriculture because of too high zinc, copper or cadmium concentrations. Growing media indexes were determined according to their impact on lettuce growth. Growing media with different pH and EC resulted in very significant impacts on height, dry matter mass and leaf area of lettuce seedlings. The highest lettuce

  4. Study on segmented distribution for reliability evaluation

    Directory of Open Access Journals (Sweden)

    Huaiyuan Li

    2017-02-01

    Full Text Available In practice, the failure rate of most equipment exhibits different tendencies at different stages and even its failure rate curve behaves a multimodal trace during its life cycle. As a result, traditionally evaluating the reliability of equipment with a single model may lead to severer errors. However, if lifetime is divided into several different intervals according to the characteristics of its failure rate, piecewise fitting can more accurately approximate the failure rate of equipment. Therefore, in this paper, failure rate is regarded as a piecewise function, and two kinds of segmented distribution are put forward to evaluate reliability. In order to estimate parameters in the segmented reliability function, Bayesian estimation and maximum likelihood estimation (MLE of the segmented distribution are discussed in this paper. Since traditional information criterion is not suitable for the segmented distribution, an improved information criterion is proposed to test and evaluate the segmented reliability model in this paper. After a great deal of testing and verification, the segmented reliability model and its estimation methods presented in this paper are proven more efficient and accurate than the traditional non-segmented single model, especially when the change of the failure rate is time-phased or multimodal. The significant performance of the segmented reliability model in evaluating reliability of proximity sensors of leading-edge flap in civil aircraft indicates that the segmented distribution and its estimation method in this paper could be useful and accurate.

  5. A Comparative Study on Evaluating the Service Quality Attributes based on Kano Model: A Case of Low-cost Carrier and Full-service Carrier

    Directory of Open Access Journals (Sweden)

    Byun Hyojeong

    2014-01-01

    Full Text Available The emergence and development of low-cost carriers(LCC with competitive price is heating up the competition in the aviation market more, especially between low-cost carriers(LCC and full-service carriers(FSC. Therefore, it became more important than ever to implement service differentiation strategies of each airline for securing customers and competitiveness. In this sense, the purpose of this study is to compare and assess the different expectations of the customers for airline service attributes pursued by FSCs and LCCs. Three main dimensions of airline service quality attributes (physical, human, and system service, were selected and this study clarified the service quality attributes of each airline carrier using Kano Model. Data were collected from Korean passengers who experienced both LCCs and FSCs for international or domestic flights. As results, this study demonstrated several differences in airline service quality attributes between FSCs and LCCs, which imply that each airline needs to adopt differential strategies to be more competitive. In particular, most physical-related attributes for FSCs were a ‘must-be’ dimension while the majority of attributes for LCCs was clarified ‘one-dimensional’ attribute. The current study also presented implications to be helpful in developing the quality of service and establishing marketing strategies for improvement in customer satisfaction.

  6. Evaluation of Mining Titles Based on Option-Pricing Model

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Limitations exist in applying discounted cash flow and analogy sales methods to evaluate mining titles. In order to find a more appropriate way of evaluating mining titles, the Black-Scholes model is discussed in this paper. The authors pay particular attention to the determination of the time to maturity of the option on the basis of characteristics of the mining industry, pointing out that a reasonable time to maturity of the option should be the remaining time after deducting the essential time, needed by exploitation of the mineral resources within the mining property, from the life of the mining title. Several conclusions, related to the exercise of mineral resource management, are drawn from a case study analysis; extending the life of a mining title within a certain range could increase the revenue to the seller of the mining title. Application of the Black-Scholes model to evaluate mining titles would encourage an expansion of the scale of production.

  7. Single-dose safety and pharmacokinetic evaluation of fluorocoxib A: pilot study of novel cyclooxygenase-2-targeted optical imaging agent in a canine model

    Science.gov (United States)

    Cekanova, Maria; Uddin, Md. Jashim; Legendre, Alfred M.; Galyon, Gina; Bartges, Joseph W.; Callens, Amanda; Martin-Jimenez, Tomas; Marnett, Lawrence J.

    2012-11-01

    We evaluated preclinical single-dose safety, pharmacokinetic properties, and specific uptake of the new optical imaging agent fluorocoxib A in dogs. Fluorocoxib A, N-[(5-carboxy-X-rhodaminyl)but-4-yl]-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamide, selectively binds and inhibits the cyclooxygenase-2 (COX-2) enzyme, which is overexpressed in many cancers. Safety pilot studies were performed in research dogs following intravenous (i.v.) administration of 0.1 and 1 mg/kg fluorocoxib A. Blood and urine samples collected three days after administration of each dose of fluorocoxib A revealed no evidence of toxicity, and no clinically relevant adverse events were noted on physical examination of exposed dogs over that time period. Pharmacokinetic parameters were assessed in additional research dogs from plasma collected at several time points after i.v. administration of fluorocoxib A using high-performance liquid chromatography analysis. The pharmacokinetic studies using 1 mg/kg showed a peak of fluorocoxib A (92±28 ng/ml) in plasma collected at 0.5 h. Tumor specific uptake of fluorocoxib A was demonstrated using a dog diagnosed with colorectal cancer expressing COX-2. Our data support the safe single-dose administration and in vivo efficacy of fluorocoxib A, suggesting a high potential for successful translation to clinical use as an imaging agent for improved tumor detection in humans.

  8. Automated expert modeling for automated student evaluation.

    Energy Technology Data Exchange (ETDEWEB)

    Abbott, Robert G.

    2006-01-01

    The 8th International Conference on Intelligent Tutoring Systems provides a leading international forum for the dissemination of original results in the design, implementation, and evaluation of intelligent tutoring systems and related areas. The conference draws researchers from a broad spectrum of disciplines ranging from artificial intelligence and cognitive science to pedagogy and educational psychology. The conference explores intelligent tutoring systems increasing real world impact on an increasingly global scale. Improved authoring tools and learning object standards enable fielding systems and curricula in real world settings on an unprecedented scale. Researchers deploy ITS's in ever larger studies and increasingly use data from real students, tasks, and settings to guide new research. With high volumes of student interaction data, data mining, and machine learning, tutoring systems can learn from experience and improve their teaching performance. The increasing number of realistic evaluation studies also broaden researchers knowledge about the educational contexts for which ITS's are best suited. At the same time, researchers explore how to expand and improve ITS/student communications, for example, how to achieve more flexible and responsive discourse with students, help students integrate Web resources into learning, use mobile technologies and games to enhance student motivation and learning, and address multicultural perspectives.

  9. Comparative analysis of used car price evaluation models

    Science.gov (United States)

    Chen, Chuancan; Hao, Lulu; Xu, Cong

    2017-05-01

    An accurate used car price evaluation is a catalyst for the healthy development of used car market. Data mining has been applied to predict used car price in several articles. However, little is studied on the comparison of using different algorithms in used car price estimation. This paper collects more than 100,000 used car dealing records throughout China to do empirical analysis on a thorough comparison of two algorithms: linear regression and random forest. These two algorithms are used to predict used car price in three different models: model for a certain car make, model for a certain car series and universal model. Results show that random forest has a stable but not ideal effect in price evaluation model for a certain car make, but it shows great advantage in the universal model compared with linear regression. This indicates that random forest is an optimal algorithm when handling complex models with a large number of variables and samples, yet it shows no obvious advantage when coping with simple models with less variables.

  10. Evaluation of modelled methane emissions over northern peatland sites

    Science.gov (United States)

    Gao, Yao; Burke, Eleanor; Chadburn, Sarah; Raivonen, Maarit; Susiluoto, Jouni; Vesala, Timo; Aurela, Mika; Lohila, Annalea; Aalto, Tuula

    2017-04-01

    Methane (CH4) is a powerful greenhouse gas, with approximately 34 times the global warming potential of carbon dioxide (CO2) over a century time horizon (IPCC, 2013). The strong sensitivity of methane emissions to environmental factors has led to concerns about potential positive feedbacks to climate change. Evaluation of the ability of the process-based land surface models of earth system models (ESMs) in simulating CH4 emission over peatland is needed for more precise future predictions. In this study, two peatland sites of poor and rich soil nutrient conditions, in southern and northern Finland respectively, are adopted. The measured CH4 fluxes at the two sites are used to evaluate the CH4 emissions simulated by the land surface model (JULES) of the UK Earth System model and by the Helsinki peatland methane emission model (HIMMELI), which is developed at Finnish Meteorological Institute and Helsinki University. In JULES, CH4 flux is simply related to soil temperature, wetland fraction and effective substrate availability. However, HIMMELI has detailed descriptions of microbial and transport processes for simulating CH4 flux. The seasonal dynamics of CH4 fluxes at the two sites are relatively well captured by both models, but model biases exist. Simulated CH4 flux is sensitive to water table depth (WTD) at both models. However, the simulated WTD is limited to be below ground in JULES. It is also important to have the annual cycle of LAI correct when coupling JULES with HIMMELI.

  11. [FREE CONSUMPTION OF GLUCOSE SOLUTION BY RATS AS A CRITERION FOR EVALUATION ITS ABSORPTION IN THE SMALL INTESTINE (Experimental study and mathematical modeling)].

    Science.gov (United States)

    Gruzdkov, A A; Gromova, L V; Dmitrieva, Yu V; Alekseeva, A S

    2015-06-01

    The aim of the work is to analyze the relationship between consumption of glucose solution by rats and its absorption, and to use this fact for assessment of the absorptive capacity of the small intestine in non anesthetized animals in vivo. Consumption of glucose solution (200 g/l) by fasted rats was recorded in the control, and after administration of phloridzin--inhibitor of glucose active transport- or 3 hours after the restriction stress. On the mathematical model we studied the relative role of factors that can influence the temporal dynamics of glucose consumption by rats. The rate of glucose consumption was observed being decreased in the presence of phloridzin (1 mM), and be increased after the stress. The results of modeling are consistent with the experimental data and show that the rate of consumption of glucose solutions considerably more depends on the transport activity of the small intestine than on glucose concentration in the solution, or on the substrate regulation of the stomach emptying. Analysis of dynamics of consumption of glucose solution by intact rats may be considered as one of promising approaches to assessing the absorptive capacity of the small intestine under natural conditions.

  12. SHEEP AS AN EXPERIMENTAL MODEL FOR BIOMATERIAL IMPLANT EVALUATION

    Science.gov (United States)

    SARTORETTO, SUELEN CRISTINA; UZEDA, MARCELO JOSÉ; MIGUEL, FÚLVIO BORGES; NASCIMENTO, JHONATHAN RAPHAELL; ASCOLI, FABIO; CALASANS-MAIA, MÔNICA DIUANA

    2016-01-01

    ABSTRACT Objective: Based on a literature review and on our own experience, this study proposes sheep as an experimental model to evaluate the bioactive capacity of bone substitute biomaterials, dental implant systems and orthopedics devices. The literature review covered relevant databases available on the Internet from 1990 until to date, and was supplemented by our own experience. Methods: For its resemblance in size and weight to humans, sheep are quite suitable for use as an experimental model. However, information about their utility as an experimental model is limited. The different stages involving sheep experiments were discussed, including the care during breeding and maintenance of the animals obtaining specimens for laboratory processing, and highlighting the unnecessary euthanasia of animals at the end of study, in accordance to the guidelines of the 3Rs Program. Results: All experiments have been completed without any complications regarding the animals and allowed us to evaluate hypotheses and explain their mechanisms. Conclusion: The sheep is an excellent animal model for evaluation of biomaterial for bone regeneration and dental implant osseointegration. From an ethical point of view, one sheep allows for up to 12 implants per animal, permitting to keep them alive at the end of the experiments. Level of Evidence II, Retrospective Study. PMID:28149193

  13. Evaluation of silicon nitride as a substrate for culture of PC12 cells: an interfacial model for functional studies in neurons.

    Directory of Open Access Journals (Sweden)

    Johan Jaime Medina Benavente

    Full Text Available Silicon nitride is a biocompatible material that is currently used as an interfacial surface between cells and large-scale integration devices incorporating ion-sensitive field-effect transistor technology. Here, we investigated whether a poly-L-lysine coated silicon nitride surface is suitable for the culture of PC12 cells, which are widely used as a model for neural differentiation, and we characterized their interaction based on cell behavior when seeded on the tested material. The coated surface was first examined in terms of wettability and topography using contact angle measurements and atomic force microscopy and then, conditioned silicon nitride surface was used as the substrate for the study of PC12 cell culture properties. We found that coating silicon nitride with poly-L-lysine increased surface hydrophilicity and that exposing this coated surface to an extracellular aqueous environment gradually decreased its roughness. When PC12 cells were cultured on a coated silicon nitride surface, adhesion and spreading were facilitated, and the cells showed enhanced morphological differentiation compared to those cultured on a plastic culture dish. A bromodeoxyuridine assay demonstrated that, on the coated silicon nitride surface, higher proportions of cells left the cell cycle, remained in a quiescent state and had longer survival times. Therefore, our study of the interaction of the silicon nitride surface with PC12 cells provides important information for the production of devices that need to have optimal cell culture-supporting properties in order to be used in the study of neuronal functions.

  14. Model-based Type B uncertainty evaluations of measurement towards more objective evaluation strategies

    NARCIS (Netherlands)

    M. Boumans

    2013-01-01

    This article proposes a more objective Type B evaluation. This can be achieved when Type B uncertainty evaluations are model-based. This implies, however, grey-box modelling and validation instead of white-box modelling and validation which are appropriate for Type A evaluation.

  15. A Logic Model for Evaluating the Academic Health Department.

    Science.gov (United States)

    Erwin, Paul Campbell; McNeely, Clea S; Grubaugh, Julie H; Valentine, Jennifer; Miller, Mark D; Buchanan, Martha

    2016-01-01

    Academic Health Departments (AHDs) are collaborative partnerships between academic programs and practice settings. While case studies have informed our understanding of the development and activities of AHDs, there has been no formal published evaluation of AHDs, either singularly or collectively. Developing a framework for evaluating AHDs has potential to further aid our understanding of how these relationships may matter. In this article, we present a general theory of change, in the form of a logic model, for how AHDs impact public health at the community level. We then present a specific example of how the logic model has been customized for a specific AHD. Finally, we end with potential research questions on the AHD based on these concepts. We conclude that logic models are valuable tools, which can be used to assess the value and ultimate impact of the AHD.

  16. Lifetime-Aware Cloud Data Centers: Models and Performance Evaluation

    Directory of Open Access Journals (Sweden)

    Luca Chiaraviglio

    2016-06-01

    Full Text Available We present a model to evaluate the server lifetime in cloud data centers (DCs. In particular, when the server power level is decreased, the failure rate tends to be reduced as a consequence of the limited number of components powered on. However, the variation between the different power states triggers a failure rate increase. We therefore consider these two effects in a server lifetime model, subject to an energy-aware management policy. We then evaluate our model in a realistic case study. Our results show that the impact on the server lifetime is far from negligible. As a consequence, we argue that a lifetime-aware approach should be pursued to decide how and when to apply a power state change to a server.

  17. WMC Database Evaluation. Case Study Report

    Energy Technology Data Exchange (ETDEWEB)

    Palounek, Andrea P. T [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-29

    The WMC Database is ultimately envisioned to hold a collection of experimental data, design information, and information from computational models. This project was a first attempt at using the Database to access experimental data and extract information from it. This evaluation shows that the Database concept is sound and robust, and that the Database, once fully populated, should remain eminently usable for future researchers.

  18. Performance evaluation of four directional emissivity analytical models with thermal SAIL model and airborne images.

    Science.gov (United States)

    Ren, Huazhong; Liu, Rongyuan; Yan, Guangjian; Li, Zhao-Liang; Qin, Qiming; Liu, Qiang; Nerry, Françoise

    2015-04-01

    Land surface emissivity is a crucial parameter in the surface status monitoring. This study aims at the evaluation of four directional emissivity models, including two bi-directional reflectance distribution function (BRDF) models and two gap-frequency-based models. Results showed that the kernel-driven BRDF model could well represent directional emissivity with an error less than 0.002, and was consequently used to retrieve emissivity with an accuracy of about 0.012 from an airborne multi-angular thermal infrared data set. Furthermore, we updated the cavity effect factor relating to multiple scattering inside canopy, which improved the performance of the gap-frequency-based models.

  19. Phototumorigenesis studies of 5-methoxypsoralen in bergamot oil: evaluation and modification of risk of human use in an albino mouse skin model.

    Science.gov (United States)

    Young, A R; Walker, S L; Kinley, J S; Plastow, S R; Averbeck, D; Morlière, P; Dubertret, L

    1990-11-01

    The skin of the female hairless albino mouse (Skh 1) was used to study the enhancement of solar simulated radiation (SSR) tumorigenesis by 5-methoxypsoralen (5-MOP) in model perfumes that contain bergamot oil. This work was done in association with yeast mutagenicity studies and human skin phototoxicity studies. Analyses of time-to-onset of tumour observation with 5-MOP at 0, 5, 15 and 50 ppm show a highly significant 5-MOP dose effect and the data indicate that 5-MOP has phototumorigenic potential even at 5 ppm. The addition of 0.5% UVB and 0.5% UVA sunscreens significantly reduces the tumorigenicity associated with the vehicle (i.e. 5-MOP at 0 ppm) and 5-MOP at all concentrations. Pairwise comparisons of 5-MOP (at 5 or 15 ppm) plus sunscreens with vehicle plus sunscreens show that the sunscreens afford total protection at the lower 5-MOP concentrations. Additional studies show that a 5-6 h delay between 5-MOP application and SSR exposure defers the time-to-onset of tumours as does intermittent 5-MOP and SSR treatment. A comparison of 5-MOP at 50 ppm in bergamot oil with 5-MOP at 50 ppm prepared from pure 5-MOP crystals shows identical results, indicating that the active phototumorigenic agent in bergamot oil is 5-MOP and not other related compounds, which may be present at greater concentrations. Analyses of tumour histology at death show, in general, similar patterns of malignancy for all groups. Thus although it is possible to delay tumorigenesis by various strategies, the tumours that eventually develop are just as likely to be malignant, if not more so, when compared with non-delayed groups.

  20. Application of a theoretical model to evaluate COPD disease management.

    Science.gov (United States)

    Lemmens, Karin M M; Nieboer, Anna P; Rutten-Van Mölken, Maureen P M H; van Schayck, Constant P; Asin, Javier D; Dirven, Jos A M; Huijsman, Robbert

    2010-03-26

    Disease management programmes are heterogeneous in nature and often lack a theoretical basis. An evaluation model has been developed in which theoretically driven inquiries link disease management interventions to outcomes. The aim of this study is to methodically evaluate the impact of a disease management programme for patients with chronic obstructive pulmonary disease (COPD) on process, intermediate and final outcomes of care in a general practice setting. A quasi-experimental research was performed with 12-months follow-up of 189 COPD patients in primary care in the Netherlands. The programme included patient education, protocolised assessment and treatment of COPD, structural follow-up and coordination by practice nurses at 3, 6 and 12 months. Data on intermediate outcomes (knowledge, psychosocial mediators, self-efficacy and behaviour) and final outcomes (dyspnoea, quality of life, measured by the CRQ and CCQ, and patient experiences) were obtained from questionnaires and electronic registries. Implementation of the programme was associated with significant improvements in dyspnoea (p model showed associations between significantly improved intermediate outcomes and improvements in quality of life and dyspnoea. The application of a theory-driven model enhances the design and evaluation of disease management programmes aimed at improving health outcomes. This study supports the notion that a theoretical approach strengthens the evaluation designs of complex interventions. Moreover, it provides prudent evidence that the implementation of COPD disease management programmes can positively influence outcomes of care.

  1. STUDY AND PRACTICE OF JSBSIM MODEL-BASED PRELIMINARY FLIGHT ABILITY EVALUATION SYSTEM%基于JSBSim模型飞行能力初步评估系统的研究与实践

    Institute of Scientific and Technical Information of China (English)

    岳显; 吉华; 王强; 樊刚; 王佳

    2015-01-01

    A preliminary flight ability evaluation system based on JSBSim model is developed to meet the requirement of the flight ability evaluation in pilot student recruitment and teaching.Firstly,the framework and main modules of this system are analysed.Then the data input and output of the system are depicted,and the JSBSim model and the method of using JSBSim model in the system are introduced as well.Finally,the evaluation rules and the algorithm of flight ability evaluation are detailed.The system realises the preliminary training and preliminary evaluation on the flight ability of the pilot student.It also has the reference value for flight dynamics model study and flight simulator development.%针对飞行学员招收、教学中对飞行学员飞行能力评估的需求,研发基于JSBSim模型的飞行能力初步评估系统。首先分析系统框架和主要模块,然后阐述系统的数据输入输出,介绍JSBSim模型以及调用方法,最后论述飞行能力的评估规则和算法。系统实现了对飞行学员飞行能力的初步锻炼和初步评估,对飞行动力学模型的研究和飞行模拟器的研发也具有参考价值。

  2. Evaluation of medical education virtual program: P3 model

    Directory of Open Access Journals (Sweden)

    RITA REZAEE

    2016-10-01

    Full Text Available Introduction: In e-learning, people get involved in a process and create the content (product and make it available for virtual learners. The present study was carried out in order to evaluate the first virtual master program in medical education at Shiraz University of Medical Sciences according to P3 Model. Methods: This is an evaluation research study with post single group design used to determine how effective this program was. All students 60 who participated more than one year in this virtual program and 21 experts including teachers and directors participated in this evaluation project. Based on the P3 e-learning model, an evaluation tool with 5-point Likert rating scale was designed and applied to collect the descriptive data. Results: Students reported storyboard and course design as the most desirable element of learning environment (2.30±0.76, but they declared technical support as the less desirable part (1.17±1.23. Conclusion: Presence of such framework in this regard and using it within the format of appropriate tools for evaluation of e-learning in universities and higher education institutes, which present e-learning curricula in the country, may contribute to implementation of the present and future e-learning curricula efficiently and guarantee its implementation in an appropriate way.

  3. Evaluation of Medical Education virtual Program: P3 model

    Science.gov (United States)

    REZAEE, RITA; SHOKRPOUR, NASRIN; BOROUMAND, MARYAM

    2016-01-01

    Introduction: In e-learning, people get involved in a process and create the content (product) and make it available for virtual learners. The present study was carried out in order to evaluate the first virtual master program in medical education at Shiraz University of Medical Sciences according to P3 Model. Methods: This is an evaluation research study with post single group design used to determine how effective this program was. All students 60 who participated more than one year in this virtual program and 21 experts including teachers and directors participated in this evaluation project. Based on the P3 e-learning model, an evaluation tool with 5-point Likert rating scale was designed and applied to collect the descriptive data. Results: Students reported storyboard and course design as the most desirable element of learning environment (2.30±0.76), but they declared technical support as the less desirable part (1.17±1.23). Conclusion: Presence of such framework in this regard and using it within the format of appropriate tools for evaluation of e-learning in universities and higher education institutes, which present e-learning curricula in the country, may contribute to implementation of the present and future e-learning curricula efficiently and guarantee its implementation in an appropriate way. PMID:27795971

  4. A Study of Single- and Double-Averaged Second-Order Models to Evaluate Third-Body Perturbation Considering Elliptic Orbits for the Perturbing Body

    Directory of Open Access Journals (Sweden)

    R. C. Domingos

    2013-01-01

    Full Text Available The equations for the variations of the Keplerian elements of the orbit of a spacecraft perturbed by a third body are developed using a single average over the motion of the spacecraft, considering an elliptic orbit for the disturbing body. A comparison is made between this approach and the more used double averaged technique, as well as with the full elliptic restricted three-body problem. The disturbing function is expanded in Legendre polynomials up to the second order in both cases. The equations of motion are obtained from the planetary equations, and several numerical simulations are made to show the evolution of the orbit of the spacecraft. Some characteristics known from the circular perturbing body are studied: circular, elliptic equatorial, and frozen orbits. Different initial eccentricities for the perturbed body are considered, since the effect of this variable is one of the goals of the present study. The results show the impact of this parameter as well as the differences between both models compared to the full elliptic restricted three-body problem. Regions below, near, and above the critical angle of the third-body perturbation are considered, as well as different altitudes for the orbit of the spacecraft.

  5. Organizational evaluation of an interprofessional study unit

    DEFF Research Database (Denmark)

    Jensen, Didde Cramer; Nørgaard, Birgitte; Draborg, Eva;

    2012-01-01

    This article presents results from an organizational evaluation of an interprofessional clinical study unit (ICS) in Denmark. The aim of this study was to test whether the ICS was based on a durable organizational concept and to identify the prerequisites for the unit to be successful....... The evaluation framework was "theory-based evaluation". A program theory was developed based on the concepts and expectations of the steering committee which initiated and designed the ICS. The program theory was tested for conflicts of interest among the stakeholders related to the ICS regarding prerequisites...

  6. A Model for Telestrok Network Evaluation

    DEFF Research Database (Denmark)

    Storm, Anna; Günzel, Franziska; Theiss, Stephan

    2011-01-01

    Different telestroke network concepts have been implemented worldwide to enable fast and efficient treatment of stroke patients in underserved rural areas. Networks could demonstrate the improvement in clinical outcome, but have so far excluded a cost-effectiveness analysis. With health economic...... was developed from the third-party payer perspective. In principle, it enables telestroke networks to conduct cost-effectiveness studies, because the majority of the required data can be extracted from health insurance companies’ databases and the telestroke network itself. The model presents a basis...

  7. Evaluation of video quality models for multimedia

    Science.gov (United States)

    Brunnström, Kjell; Hands, David; Speranza, Filippo; Webster, Arthur

    2008-02-01

    The Video Quality Experts Group (VQEG) is a group of experts from industry, academia, government and standards organizations working in the field of video quality assessment. Over the last 10 years, VQEG has focused its efforts on the evaluation of objective video quality metrics for digital video. Objective video metrics are mathematical models that predict the picture quality as perceived by an average observer. VQEG has completed validation tests for full reference objective metrics for the Standard Definition Television (SDTV) format. From this testing, two ITU Recommendations were produced. This standardization effort is of great relevance to the video industries because objective metrics can be used for quality control of the video at various stages of the delivery chain. Currently, VQEG is undertaking several projects in parallel. The most mature project is concerned with objective measurement of multimedia content. This project is probably the largest coordinated set of video quality testing ever embarked upon. The project will involve the collection of a very large database of subjective quality data. About 40 subjective assessment experiments and more than 160,000 opinion scores will be collected. These will be used to validate the proposed objective metrics. This paper describes the test plan for the project, its current status, and one of the multimedia subjective tests.

  8. Aerosol transport and wet scavenging in deep convective clouds: a case study and model evaluation using a multiple passive tracer analysis approach

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Qing; Easter, Richard C.; Campuzano-Jost, Pedro; Jimenez, Jose L.; Fast, Jerome D.; Ghan, Steven J.; Wang, Hailong; Berg, Larry K.; Barth, Mary; Liu, Ying; Shrivastava, ManishKumar B.; Singh, Balwinder; Morrison, H.; Fan, Jiwen; Ziegler, Conrad L.; Bela, Megan; Apel, Eric; Diskin, G. S.; Mikoviny, Tomas; Wisthaler, Armin

    2015-08-20

    The effect of wet scavenging on ambient aerosols in deep, continental convective clouds in the mid-latitudes is studied for a severe storm case in Oklahoma during the Deep Convective Clouds and Chemistry (DC3) field campaign. A new passive-tracer based transport analysis framework is developed to characterize the convective transport based on the vertical distribution of several slowly reacting and nearly insoluble trace gases. The passive gas concentration in the upper troposphere convective outflow results from a mixture of 47% from the lower level (0-3 km), 21% entrained from the upper troposphere, and 32% from mid-atmosphere based on observations. The transport analysis framework is applied to aerosols to estimate aerosol transport and wet-scavenging efficiency. Observations yield high overall scavenging efficiencies of 81% and 68% for aerosol mass (Dp < 1μm) and aerosol number (0.03< Dp < 2.5μm), respectively. Little chemical selectivity to wet scavenging is seen among observed submicron sulfate (84%), organic (82%), and ammonium (80%) aerosols, while nitrate has a much lower scavenging efficiency of 57% likely due to the uptake of nitric acid. Observed larger size particles (0.15 - 2.5μm) are scavenged more efficiently (84%) than smaller particles (64%; 0.03 - 0.15μm). The storm is simulated using the chemistry version of the WRF model. Compared to the observation based analysis, the standard model underestimates the wet scavenging efficiency for both mass and number concentrations with low biases of 31% and 40%, respectively. Adding a new treatment of secondary activation significantly improves simulation results, so that the bias in scavenging efficiency in mass and number concentrations is reduced to <10%. This supports the hypothesis that secondary activation is an important process for wet removal of aerosols in deep convective storms.

  9. Modeling and evaluating user behavior in exploratory visual analysis

    Energy Technology Data Exchange (ETDEWEB)

    Reda, Khairi; Johnson, Andrew E.; Papka, Michael E.; Leigh, Jason

    2016-10-01

    Empirical evaluation methods for visualizations have traditionally focused on assessing the outcome of the visual analytic process as opposed to characterizing how that process unfolds. There are only a handful of methods that can be used to systematically study how people use visualizations, making it difficult for researchers to capture and characterize the subtlety of cognitive and interaction behaviors users exhibit during visual analysis. To validate and improve visualization design, however, it is important for researchers to be able to assess and understand how users interact with visualization systems under realistic scenarios. This paper presents a methodology for modeling and evaluating the behavior of users in exploratory visual analysis. We model visual exploration using a Markov chain process comprising transitions between mental, interaction, and computational states. These states and the transitions between them can be deduced from a variety of sources, including verbal transcripts, videos and audio recordings, and log files. This model enables the evaluator to characterize the cognitive and computational processes that are essential to insight acquisition in exploratory visual analysis, and reconstruct the dynamics of interaction between the user and the visualization system. We illustrate this model with two exemplar user studies, and demonstrate the qualitative and quantitative analytical tools it affords.

  10. Case Study Evaluations: A Decade of Progress?

    Science.gov (United States)

    Yin, Robert K.

    1997-01-01

    In the last 10 years, there has been increased use of case study methodology, with accompanying refinement and improvement of the methods. Case studies have become legitimate research methods in evaluation, but it is too soon to say whether improvements in methodology are really resulting in improvements in the case studies conducted. (SLD)

  11. Case Study Evaluations: A Decade of Progress?

    Science.gov (United States)

    Yin, Robert K.

    1997-01-01

    In the last 10 years, there has been increased use of case study methodology, with accompanying refinement and improvement of the methods. Case studies have become legitimate research methods in evaluation, but it is too soon to say whether improvements in methodology are really resulting in improvements in the case studies conducted. (SLD)

  12. Evaluations of an Experiential Gaming Model

    Directory of Open Access Journals (Sweden)

    Kristian Kiili

    2006-01-01

    Full Text Available This paper examines the experiences of players of a problem-solving game. The main purpose of the paper is to validate the flow antecedents included in an experiential gaming model and to study their influence on the flow experience. Additionally, the study aims to operationalize the flow construct in a game context and to start a scale development process for assessing the experience of flow in game settings. Results indicated that the flow antecedents studied—challenges matched to a player’s skill level, clear goals, unambiguous feedback, a sense of control, and playability—should be considered in game design because they contribute to the flow experience. Furthermore, the indicators of the actual flow experience were distinguished.

  13. Mechanistic Evaluation for Mixed-field Agglutination in the K562 Cell Study Model with Exon 3 Deletion of A1 Gene.

    Science.gov (United States)

    Chen, Ding-Ping; Tseng, Ching-Ping; Lin, Chi-Jui; Wang, Wei-Ting; Sun, Chien-Feng

    2015-01-01

    In the case of blood type B3 with typical mixed-field agglutination of RBCs in the presence of anti-B or anti-AB antibody, a number of genetic alternations have been reported. It is well known that the IVS3+5G→A mutation in the B gene destroys the consensus of the splice donor site leading to exon 3 skipping during mRNA splicing. The lack of exon 3 likely causes a short stem region, producing an unstable B3 protein, and is concomitant with a decrease in B3 protein expression. Whether the phenomenon also appears in the type A blood group is of question. In this study, we evaluate whether exon 3 deletion in the blood type A gene also results in mixed-field phenotype. Site-directed mutagenesis was used to generate cDNA encoding A1 gene with exon 3 deletion. The cDNA was stably expressed in K562 cells. The expression of A antigen was compared with expression in parental K562 cells that did not express A antigen and in the stable K562 cell line expressing A(1) cDNA by flow cytometry analyses. The expression of A antigen in A1 stable cells and parental K562 cells was set as 100% and 0%, respectively. The mean relative percentage of A antigen expression for the cells of A1 with exon 3 deletion was 59.9% of A1 stable cells. Consistent with the observations of B3, which is B gene with exon 3 deletion, mixed field agglutination was observed for the cells expressing A1 with exon 3 deletion. Exon 3 deletion results in mixed field phenotype in both type A and B RBCs. However, the degree of antigen expression change for exon 3 deletion in A gene was less severe when compared with the deletion occurred in B gene.

  14. Imidazolidine-4-one derivatives in the search for novel chemosensitizers of Staphylococcus aureus MRSA: synthesis, biological evaluation and molecular modeling studies.

    Science.gov (United States)

    Matys, Anna; Podlewska, Sabina; Witek, Karolina; Witek, Jagna; Bojarski, Andrzej J; Schabikowski, Jakub; Otrębska-Machaj, Ewa; Latacz, Gniewomir; Szymańska, Ewa; Kieć-Kononowicz, Katarzyna; Molnar, Joseph; Amaral, Leonard; Handzlik, Jadwiga

    2015-08-28

    A series of amine derivatives of 5-aromatic imidazolidine-4-ones (7-19), representing three subgroups: piperazine derivatives of 5-arylideneimidazolones (7-13), piperazine derivatives of 5-arylideneimidazolidine-2,4-dione (14-16) and primary amines of 5-naphthyl-5-methylimidazolidine-2,4-diones (17-19), was evaluated for their ability to improve antibiotics effectiveness in two strains of Gram-positive Staphylococcus aureus: ATCC 25923 (a reference strain) and MRSA (methicillin resistant S. aureus) HEMSA 5 (a resistant clinical isolate). The latter compounds (17-19) were obtained by 4-step synthesis using Bucherer-Bergs condensation, two-phase bromoalkylation and Gabriel reactions. The naphthalen derivative: (Z)-5-(naphthalen-2-ylmethylene)-2-(piperazin-1-yl)-3H-imidazol-4(5H)-one (10) was the most potent in combination with β-lactam antibiotics and ciprofloxacin against the resistant strain. The high potency to increase efficacy of oxacillin was noted for (Z)-5-(anthracen-10-ylmethylene)-2-(piperazin-1-yl)-3H-imidazol-4(5H)one (12) too. In order to explain the mechanism of action of the compounds 10 and 12, docking studies with the use of crystal structures of a penicillin binding protein (PBP2a) and MecR1 were carried out. Their outcomes suggested that the most probable mechanism of action of the active compounds is the interaction with MecR1. Molecular dynamic experiments performed for the active compounds and compound 13 (structurally similar to 12) supported this hypothesis and provided possible explanation of activity dependencies of the tested compounds in terms of the restoration of antibiotic efficacy in S. aureus MRSA HEMSA 5.

  15. Performance evaluation of quality monitor models in spot welding

    Institute of Scientific and Technical Information of China (English)

    Zhang Zhongdian; Li Dongqing; Wang Kai

    2005-01-01

    Performance of quality monitor models in spot welding determines the monitor precision directly, so it's crucial to evaluate it. Previously, mean square error ( MSE ) is often used to evaluate performances of models, but it can only show the total errors of finite specimens of models, and cannot show whether the quality information inferred from models are accurate and reliable enough or not. For this reason, by means of measure error theory, a new way to evaluate the performances of models according to the error distributions is developed as follows: Only if correct and precise enough the error distribution of model is, the quality information inferred from model is accurate and reliable.

  16. Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.

    Science.gov (United States)

    Thiratmatrakul, Supatra; Yenjai, Chavi; Waiwut, Pornthip; Vajragupta, Opa; Reubroycharoen, Prasert; Tohda, Michihisa; Boonyarat, Chantana

    2014-03-21

    New tacrine-carbazole hybrids were developed as potential multifunctional anti-Alzheimer agents for their cholinesterase inhibitory and radical scavenging activities. The developed compounds showed high inhibitory activity on acetylcholinesterase (AChE) with IC50 values ranging from 0.48 to 1.03 μM and exhibited good inhibition selectivity against AChE over butyrylcholinesterase (BuChE). Molecular modeling studies revealed that these tacrine-carbazole hybrids interacted simultaneously with the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. The derivatives containing methoxy group showed potent ABTS radical scavenging activity. Considering their neuroprotection, our results indicate that these derivatives can reduce neuronal death induced by oxidative stress and β-amyloid (Aβ). Moreover, S1, the highest potency for both radical scavenging and AChE inhibitory activity, exhibited an ability to improve both short-term and long-term memory deficit in mice induced by scopolamine. Overall, tacrine-carbazole derivatives can be considered as a candidate with potential impact for further pharmacological development in Alzheimer's therapy.

  17. EVALUATION OF CIRRHOTIC LIVER WITH PERFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING: A PRELIMINARY EXPERIMENTAL STUDY IN ANIMAL MODELS WITH HALF-LIVER CIRRHOSIS

    Institute of Scientific and Technical Information of China (English)

    Zheng-han Yang; Xiao-hua Ye; Ye Tan; Min Zhang; Ming-zhu Zhou; Jing-xia Xie; Min Chen; Cheng Zhou

    2006-01-01

    Objective To investigate the role of perfusion-weighted magnetic resonance imaging (MRI) in evaluation of cirrhotic liver.Methods With a 4F catheter,1% diluted carbon tetrachloride (1 ml/kg) was selectively injected into right or left hepatic artery of 12 dogs fortnightly.The half liver into which carbon tetrachloride was injected was called as study side (SS),while the other half liver without carbon tetrachloride injection was called as study control side (SCS).Conventional and perfusion-weighted MRI were performed in every 4 weeks.Via a 4F catheter,5ml gadolinium diethylentriamine pentaaceti acid (Gd-DTPA) dilution was injected into superior mesenteric artery at the 5th scan.The signal intensity-time curves of SS,SCS,and portal vein were completed in MR workstation.The maximal relative signal increase (MRSI),peak time (tp),and slope of the curves were measured.Results On conventional MR images,no abnormalities of externality and signal intensity were observed in both SS and SCS of liver at each stage.The mean tp,MRSI,and slope of intensity-time curves in normal liver were 10.56 seconds,1.01,and 10.23 arbitrary unit (au)/s,respectively.Three parameters of curves didn't show obvious change in SCS of liver at every stage.Abnormal perfusion curves occurred in SS of liver at the 12th week after the 1st injection.The abnormality of perfusion curve in SS was more and more serious as the times of injection increased.The mean tp,MRSI,and slope intensity-time curves in SS of liver were 19.45 seconds,0.43,and 3.60 au/s respectively at the 24th week.Conclusion Perfusion-weighted imaging can potentially provide information about portal perfusion of hepatic parenchyma,and to some degree,reflect the severity of cirrhosis.

  18. Regional landslide hazard assessment based on Distance Evaluation Model

    Institute of Scientific and Technical Information of China (English)

    Jiacun LI; Yan QIN; Jing LI

    2008-01-01

    There are many factors influencing landslide occurrence. The key for landslide control is to confirm the regional landslide hazard factors. The Cameron Highlands of Malaysia was selected as the study area. By bivariate statistical analysis method with GIS software the authors analyzed the relationships among landslides and environmental factors such as lithology, geomorphy, elevation, road and land use. Distance Evaluation Model was developed with Landslide Density(LD). And the assessment of landslide hazard of Cameron Highlands was performed. The result shows that the model has higher prediction precision.

  19. Modeling Healthcare Processes Using Commitments: An Empirical Evaluation

    Science.gov (United States)

    2015-01-01

    The two primary objectives of this paper are: (a) to demonstrate how Comma, a business modeling methodology based on commitments, can be applied in healthcare process modeling, and (b) to evaluate the effectiveness of such an approach in producing healthcare process models. We apply the Comma approach on a breast cancer diagnosis process adapted from an HHS committee report, and presents the results of an empirical study that compares Comma with a traditional approach based on the HL7 Messaging Standard (Traditional-HL7). Our empirical study involved 47 subjects, and two phases. In the first phase, we partitioned the subjects into two approximately equal groups. We gave each group the same requirements based on a process scenario for breast cancer diagnosis. Members of one group first applied Traditional-HL7 and then Comma whereas members of the second group first applied Comma and then Traditional-HL7—each on the above-mentioned requirements. Thus, each subject produced two models, each model being a set of UML Sequence Diagrams. In the second phase, we repartitioned the subjects into two groups with approximately equal distributions from both original groups. We developed exemplar Traditional-HL7 and Comma models; we gave one repartitioned group our Traditional-HL7 model and the other repartitioned group our Comma model. We provided the same changed set of requirements to all subjects and asked them to modify the provided exemplar model to satisfy the new requirements. We assessed solutions produced by subjects in both phases with respect to measures of flexibility, time, difficulty, objective quality, and subjective quality. Our study found that Comma is superior to Traditional-HL7 in flexibility and objective quality as validated via Student’s t-test to the 10% level of significance. Comma is a promising new approach for modeling healthcare processes. Further gains could be made through improved tooling and enhanced training of modeling personnel. PMID

  20. Developing a Kano-Based Evaluation Model for Innovation Design

    Directory of Open Access Journals (Sweden)

    Chang-Tzuoh Wu

    2015-01-01

    Full Text Available This research focuses on developing a psychology-based evaluation procedure for innovative design. The divergent thinking part of the main innovative design procedure which discussed in this paper is the extensive QFD developed by the author (Wu. The major performance of QFD is to identify the customers’ requirements and their priorities. Then, the proposed extensive QFD helps transform the high priority requirements into appropriate technical characteristics. According to the priorities of product characteristics, the prior engineering parameters will be identified to be the key performances to redesign. For identifying the requirements and achieving the attractive design, we introduce the Kano model to construct the evaluation model. The proposed Kano-based evaluation procedure is mainly used in two stages of the innovative design. First, the evaluation process was used in QFD stage to help identify attractive customers’ requirements, and the other was used in the extension stage to help assess concepts. The flowchart of proposed innovative design procedure with psychology-based evaluation has also been developed. A case study, exercise equipment design, is adopted to explain and verify feasibility of the proposed approach.

  1. A merged model of quality improvement and evaluation: maximizing return on investment.

    Science.gov (United States)

    Woodhouse, Lynn D; Toal, Russ; Nguyen, Trang; Keene, DeAnna; Gunn, Laura; Kellum, Andrea; Nelson, Gary; Charles, Simone; Tedders, Stuart; Williams, Natalie; Livingood, William C

    2013-11-01

    Quality improvement (QI) and evaluation are frequently considered to be alternative approaches for monitoring and assessing program implementation and impact. The emphasis on third-party evaluation, particularly associated with summative evaluation, and the grounding of evaluation in the social and behavioral science contrast with an emphasis on the integration of QI process within programs or organizations and its origins in management science and industrial engineering. Working with a major philanthropic organization in Georgia, we illustrate how a QI model is integrated with evaluation for five asthma prevention and control sites serving poor and underserved communities in rural and urban Georgia. A primary foundation of this merged model of QI and evaluation is a refocusing of the evaluation from an intimidating report card summative evaluation by external evaluators to an internally engaged program focus on developmental evaluation. The benefits of the merged model to both QI and evaluation are discussed. The use of evaluation based logic models can help anchor a QI program in evidence-based practice and provide linkage between process and outputs with the longer term distal outcomes. Merging the QI approach with evaluation has major advantages, particularly related to enhancing the funder's return on investment. We illustrate how a Plan-Do-Study-Act model of QI can (a) be integrated with evaluation based logic models, (b) help refocus emphasis from summative to developmental evaluation, (c) enhance program ownership and engagement in evaluation activities, and (d) increase the role of evaluators in providing technical assistance and support.

  2. Constructing a Travel Risks’ Evaluation Model for Tour Freelancers Based on the ANP Approach

    Directory of Open Access Journals (Sweden)

    Chin-Tsai Lin

    2016-01-01

    Full Text Available This study constructs a new travel risks’ evaluation model for freelancers to evaluate and select tour groups by considering the interdependencies of the evaluation criteria used. First of all, the proposed model adopts the Nominal Group Technique (NGT to identify suitable evaluation criteria for evaluating travel risks. Six evaluation criteria and 18 subcriteria are obtained. The six evaluation criteria are financial risk, transportation risk, social risk, hygiene risk, sightseeing spot risk, and general risk for freelancer tour groups. Secondly, the model uses the analytic network process (ANP to determine the relative weight of the criteria. Finally, examples of group package tours (GPTs are used to demonstrate the travel risk evaluation process for this model. The results show that the Tokyo GPT is the best group tour. The proposed model helps freelancers to effectively evaluate travel risks and decision-making, making it highly applicable to academia and tour groups.

  3. Curriculum evaluation and revision in a nascent field: the utility of the retrospective pretest--posttest model in a homeland security program of study.

    Science.gov (United States)

    Pelfrey, William V; Pelfrey, William V

    2009-02-01

    Although most academic disciplines evolve at a measured pace, the emerging field of homeland security must, for reasons of safety and security, evolve rapidly. The Department of Homeland Security sponsored the establishment of a graduate educational program for key officials holding homeland security roles. Because homeland security is a nascent field, the establishment of a program curriculum was forced to draw from a variety of disciplines. Curriculum evaluation was complicated by the rapid changes occurring in the emerging discipline, producing response shift bias, and interfering with the pre-post assessments. To compensate for the validity threat associated with response shift bias, a retrospective pretest-posttest evaluative methodology was used. Data indicate the program has evolved in a significant and orderly fashion and these data support the use of this innovative evaluation approach in the development of any discipline.

  4. Nutritional evaluation of senior: a bibliographical study

    OpenAIRE

    Nara Carneiro Lacerda; Silvana Sidney Costa Santos

    2012-01-01

    The aim of this study was to research about the senior’s nutritional evaluation using bibliographical rising in the base of the bibliographical data LILACS. 24 references were found, being 11 scientific articles: 5 bibliographical and 6 of prevalence. Of the investigated material, 9 were accomplished in the Brazilian Southeast. As for the nutritional evaluation it was verified that the seniors have presented larger overweight prevalence and obesity, most of them were of women. It was noticed ...

  5. Evaluating Office Environments: A Case Study

    Science.gov (United States)

    1994-05-01

    The importance of a follow-up, post occupancy evaluation that challenges the redesigned product also is illustrated. The study shows the information...of Age, memo (Architecture Team, USACERL, February 13, 1992), pp 1-6. Weidemann, S., and J.R. Anderson, "Issues in the Analysis of Post - Occupancy Studies

  6. Help-seeking in relation to signs of dementia: a pilot study to evaluate the utility of the common-sense model of illness representations.

    Science.gov (United States)

    Hamilton-West, Kate E; Milne, Alisoun J; Chenery, Alison; Tilbrook, Carolyn

    2010-10-01

    Despite the importance of early diagnosis of dementia, little is known about the factors underlying help-seeking in relation to signs of the condition. In this pilot study, we aimed to examine the potential utility of the common sense model (CSM) of illness representations for understanding lay perceptions of dementia and predicting intentions to seek help in relation to possible signs and symptoms. A secondary aim was to develop a measure of (dementia-related) illness representations as a tool for future research. After reading a vignette describing a "relative" with mild or moderate dementia, participants (N = 118) completed measures of illness representations and help-seeking intentions. Analyses compared perceptions of the mild and moderate vignettes and determined the extent to which illness perceptions differentiated between alternative forms of help-seeking (e.g. seeking professional help vs. help from family members). Results indicated that cognitive deficits were more readily identified as dementia than non-cognitive symptoms; these were commonly attributed to stress or depression. Participants were more likely to indicate an intention to seek professional help if they identified the problem in the vignette as dementia, perceived symptoms as severe, as having serious consequences and as likely to be permanent, but less likely to do so if they identified the problem as stress or attributed symptoms to psychological causes. Our preliminary data suggests that help-seeking may be prevented by inaccurate illness representations or misattribution of symptoms. The CSM may provide a useful framework for understanding perceptions of dementia symptoms and for informing help-seeking pathways.

  7. Covalent modification of a melanoma-derived antigenic peptide with a natural quinone methide. Preliminary chemical, molecular modelling and immunological evaluation studies.

    Science.gov (United States)

    Douat-Casassus, Céline; Marchand-Geneste, Nathalie; Diez, Elisabeth; Aznar, Céline; Picard, Philippe; Geoffre, Serge; Huet, Aline; Bourguet-Kondracki, Marie-Lise; Gervois, Nadine; Jotereau, Francine; Quideau, Stéphane

    2006-05-01

    A LigandFit shape-directed docking methodology was used to identify the best position at which the melanoma-derived MHC class-I HLA-A2-binding antigenic peptide ELAGIGILTV could be modified by attaching a small molecule capable of fitting at the interface of complementary determining regional (CDR) loops of a T-cell receptor (TCR) while triggering T-cell responses. The small molecule selected here for determining the feasibility of this alternative track to chemical alteration of antigenic peptides was the electrophilic quinone methide (+)-puupehenone (), a natural product that belongs to a family of marine metabolites capable of expressing immunomodulatory activities. A preliminary chemical reactivity model study revealed the efficacy of the thiol group of a cysteine (C) side-chain in its nucleophilic addition reaction with in a regio- and diastereoselective manner. The best TCR/HLA-A2 ligand [i.e., ELAGCGILTV-S-puupehenol ()] then identified by the LigandFit docking procedure was synthesized and used to pulse HLA-A2(+) T2 cells for T-cell stimulation. Among the ELAGIGILTV-specific T-cell clones we tested, five of them recognized the conjugate in spite of its low binding affinity for the HLA-A2 molecules. The resulting T-cell stimulation was determined through the intracytoplasmic secretion of IFN-gamma and the percentage of T-cells thus activated. These highly encouraging results indicate that small non-peptidic natural product-derived molecules attached onto the central part of an antigenic peptide can fit at the TCR/HLA-A2 interface with induction of T-cell responses.

  8. Distributed multi-criteria model evaluation and spatial association analysis

    Science.gov (United States)

    Scherer, Laura; Pfister, Stephan

    2015-04-01

    Model performance, if evaluated, is often communicated by a single indicator and at an aggregated level; however, it does not embrace the trade-offs between different indicators and the inherent spatial heterogeneity of model efficiency. In this study, we simulated the water balance of the Mississippi watershed using the Soil and Water Assessment Tool (SWAT). The model was calibrated against monthly river discharge at 131 measurement stations. Its time series were bisected to allow for subsequent validation at the same gauges. Furthermore, the model was validated against evapotranspiration which was available as a continuous raster based on remote sensing. The model performance was evaluated for each of the 451 sub-watersheds using four different criteria: 1) Nash-Sutcliffe efficiency (NSE), 2) percent bias (PBIAS), 3) root mean square error (RMSE) normalized to standard deviation (RSR), as well as 4) a combined indicator of the squared correlation coefficient and the linear regression slope (bR2). Conditions that might lead to a poor model performance include aridity, a very flat and steep relief, snowfall and dams, as indicated by previous research. In an attempt to explain spatial differences in model efficiency, the goodness of the model was spatially compared to these four phenomena by means of a bivariate spatial association measure which combines Pearson's correlation coefficient and Moran's index for spatial autocorrelation. In order to assess the model performance of the Mississippi watershed as a whole, three different averages of the sub-watershed results were computed by 1) applying equal weights, 2) weighting by the mean observed river discharge, 3) weighting by the upstream catchment area and the square root of the time series length. Ratings of model performance differed significantly in space and according to efficiency criterion. The model performed much better in the humid Eastern region than in the arid Western region which was confirmed by the

  9. Rhode Island Model Evaluation & Support System: Teacher. Edition III

    Science.gov (United States)

    Rhode Island Department of Education, 2015

    2015-01-01

    Rhode Island educators believe that implementing a fair, accurate, and meaningful educator evaluation and support system will help improve teaching and learning. The primary purpose of the Rhode Island Model Teacher Evaluation and Support System (Rhode Island Model) is to help all teachers improve. Through the Model, the goal is to help create a…

  10. Evaluation of Fabric Hand with Grey Element Model

    Institute of Scientific and Technical Information of China (English)

    CHEN Dong-sheng; GAN Ying-jin; BAI Yue

    2004-01-01

    A premium composite grey element model is established and used for objective evaluation of fabric hand. Fabric hand is regarded as a grey system and the model is composed of fabric mechanical properties, which are primary hand attributes. Based on comparison with a standard model, fabric hand can be objectively evaluated.

  11. Saltstone SDU6 Modeling Study

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Si Y. [Savannah River Site (SRS), Aiken, SC (United States); Hyun, Sinjae [Mercer University, Macon, GA (United States)

    2013-01-10

    A new disposal unit, designated as Saltstone Disposal Unit 6 (SDU6), is being designed for support of site accelerated closure goals and salt waste projections identified in the new Liquid Waste System Plan. The unit is a cylindrical disposal cell of 375 ft in diameter and 43 ft in height, and it has a minimum 30 million gallons of capacity. SRNL was requested to evaluate the impact of an increased grout placement height on the flow patterns radially spread on the floor and to determine whether grout quality is impacted by the height. The primary goals of the work are to develop the baseline Computational Fluid Dynamics (CFD) model and to perform the evaluations for the flow patterns of grout material in SDU6 as a function of elevation of grout discharge port and grout rheology. Two transient grout models have been developed by taking a three-dimensional multiphase CFD approach to estimate the domain size of the grout materials radially spread on the facility floor and to perform the sensitivity analysis with respect to the baseline design and operating conditions such as elevation height of the discharge port and fresh grout properties. For the CFD modeling calculations, air-grout Volume of Fluid (VOF) method combined with Bingham plastic and time-dependent grout models were used for examining the impact of fluid spread performance for the initial baseline configurations and to evaluate the impact of grout pouring height on grout quality. The grout quality was estimated in terms of the air volume fraction for the grout layer formed on the SDU6 floor, resulting in the change of grout density. The study results should be considered as preliminary scoping analyses since benchmarking analysis is not included in this task scope. Transient analyses with the Bingham plastic model were performed with the FLUENTTM code on the high performance parallel computing platform in SRNL. The analysis coupled with a transient grout aging model was performed by using ANSYS-CFX code

  12. Saltstone SDU6 Modeling Study

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Si Y. [Savannah River Site (SRS), Aiken, SC (United States); Hyun, Sinjae [Mercer University, Macon, GA (United States)

    2013-01-10

    A new disposal unit, designated as Saltstone Disposal Unit 6 (SDU6), is being designed for support of site accelerated closure goals and salt waste projections identified in the new Liquid Waste System Plan. The unit is a cylindrical disposal cell of 375 ft in diameter and 43 ft in height, and it has a minimum 30 million gallons of capacity. SRNL was requested to evaluate the impact of an increased grout placement height on the flow patterns radially spread on the floor and to determine whether grout quality is impacted by the height. The primary goals of the work are to develop the baseline Computational Fluid Dynamics (CFD) model and to perform the evaluations for the flow patterns of grout material in SDU6 as a function of elevation of grout discharge port and grout rheology. Two transient grout models have been developed by taking a three-dimensional multiphase CFD approach to estimate the domain size of the grout materials radially spread on the facility floor and to perform the sensitivity analysis with respect to the baseline design and operating conditions such as elevation height of the discharge port and fresh grout properties. For the CFD modeling calculations, air-grout Volume of Fluid (VOF) method combined with Bingham plastic and time-dependent grout models were used for examining the impact of fluid spread performance for the initial baseline configurations and to evaluate the impact of grout pouring height on grout quality. The grout quality was estimated in terms of the air volume fraction for the grout layer formed on the SDU6 floor, resulting in the change of grout density. The study results should be considered as preliminary scoping analyses since benchmarking analysis is not included in this task scope. Transient analyses with the Bingham plastic model were performed with the FLUENTTM code on the high performance parallel computing platform in SRNL. The analysis coupled with a transient grout aging model was performed by using ANSYS-CFX code

  13. Application of a theoretical model to evaluate COPD disease management

    Directory of Open Access Journals (Sweden)

    Asin Javier D

    2010-03-01

    Full Text Available Abstract Background Disease management programmes are heterogeneous in nature and often lack a theoretical basis. An evaluation model has been developed in which theoretically driven inquiries link disease management interventions to outcomes. The aim of this study is to methodically evaluate the impact of a disease management programme for patients with chronic obstructive pulmonary disease (COPD on process, intermediate and final outcomes of care in a general practice setting. Methods A quasi-experimental research was performed with 12-months follow-up of 189 COPD patients in primary care in the Netherlands. The programme included patient education, protocolised assessment and treatment of COPD, structural follow-up and coordination by practice nurses at 3, 6 and 12 months. Data on intermediate outcomes (knowledge, psychosocial mediators, self-efficacy and behaviour and final outcomes (dyspnoea, quality of life, measured by the CRQ and CCQ, and patient experiences were obtained from questionnaires and electronic registries. Results Implementation of the programme was associated with significant improvements in dyspnoea (p Conclusions The application of a theory-driven model enhances the design and evaluation of disease management programmes aimed at improving health outcomes. This study supports the notion that a theoretical approach strengthens the evaluation designs of complex interventions. Moreover, it provides prudent evidence that the implementation of COPD disease management programmes can positively influence outcomes of care.

  14. Comprehensive evaluation of Shahid Motahari Educational Festival during 2008-2013 based on CIPP Evaluation Model

    Directory of Open Access Journals (Sweden)

    SN Hosseini

    2014-09-01

    Full Text Available Introduction: Education quality improvement is one of the main goals of higher education. In this regard, has been provided various solutions such as holding educational Shahid Motahari annual festivals, in order to appreciate of educational process, development and innovation educational processes and procedures, preparation of calibration standards and processes of accrediting educational. The aim of this study was to comprehensive evaluating of educational Shahid Motahari festival during six periods (2008-2013 based on CIPP evaluation model. Method : This cross-sectional study was conducted among the 473 faculty members include deputies and administrators educational, administrators and faculty members of medical education development centers, members of the scientific committee and faculty member’s participants in Shahid Motahari festival from 42 universities medical sciences of Iran. Data collection based on self-report writing questionnaires. Data were analyzed by SPSS version 20 at α=0.05 significant level. Results: The subjects reported 75.13%, 65.33%, 64.5%, and 59.21 % of receivable scores of process, context, input and product, respectively. In addition, there was a direct and significant correlation between all domains . Conclusion : According to the study findings, in the evaluation and correlation of domains models, we can explicitly how to holding festivals was appropriate and the main reason for the poor evaluation in product domain is related to the problems in input and product domains.

  15. An evaluation study of WRF-ARW model with observations during a usual low pressure system over eastern Mediterranean area (Greece) and comparison of the results with an extreme weather event

    Science.gov (United States)

    Emmanouil, George; Vlachogiannis, Diamanto; Sfetsos, Athanasios; Karozis, Stelios; Tasopoulou, Antonia

    2016-04-01

    The accurate simulation of weather conditions is becoming more and more an issue of increased research interest and public demand. Because of the uncertainty in forecasting such phenomena, the investigation of the choice of a proper model configuration to simulate in a satisfactory way usual weather conditions, as well as extreme events is of crucial importance. In the framework of providing reliable weather forecasting, the WRF atmospheric model was employed to simulate the weather conditions during a usual for the area low pressure system that passed over the Greek peninsula during 2015 (September, 18-24). NCEP FNL analysis data were used for model input. The model configuration was setup to include three nested domains with increasing horizontal resolution inwards (11km, 2km and 0.5km respectively), centered in Attica area. The model parameterization was concluded following a number of sensitivity tests, previously carried out for other weather events including extremes in the same area, such as the Cleopatra cyclone. The main meteorological variables were analyzed and evaluation of the results was performed against in-situ measurements by the network of the Hellenic National Meteorological Service stations. The comparison of the September low-pressure event and the Cleopatra case study model results in temperature showed good agreement with the observations in both cases. Study of the precipitation fields yielded significant improvement compared to the analysis data of the NCEP FNL and the comparison between the model results and observed values was found to be good locally at some stations. The overall conclusion was that the model parameterization and applied methodology proved to be an efficient and useful tool for studying and forecasting such events.

  16. ¿Evaluating or patchworking? An Evaluand-oriented Responsive Evaluation Model

    Directory of Open Access Journals (Sweden)

    Iván Jorrín Abellán

    2009-12-01

    Full Text Available This article presents the CSCL Evaluand-Oriented Responsive Evaluation Model, an evolving evaluation model, conceived as a “boundary object”, to be used in the evaluation of a wide range of CSCL systems. The model relies on a responsive evaluation approach and tries to provide potential evaluators with a practical tool to evaluate CSCL systems. The article is driven by a needlework metaphor that tries to illustrate the complexity of the traditions, perspectives and practical issues that converge in this proposal.

  17. Evaluation of black carbon estimations in global aerosol models

    NARCIS (Netherlands)

    Koch, D.; Schulz, M.; McNaughton, C.; Spackman, J.R.; Balkanski, Y.; Bauer, S.; Krol, M.C.

    2009-01-01

    We evaluate black carbon (BC) model predictions from the AeroCom model intercomparison project by considering the diversity among year 2000 model simulations and comparing model predictions with available measurements. These model-measurement intercomparisons include BC surface and aircraft concentr

  18. Principal component and factor analytic models in international sire evaluation

    Directory of Open Access Journals (Sweden)

    Jakobsen Jette

    2011-09-01

    Full Text Available Abstract Background Interbull is a non-profit organization that provides internationally comparable breeding values for globalized dairy cattle breeding programmes. Due to different trait definitions and models for genetic evaluation between countries, each biological trait is treated as a different trait in each of the participating countries. This yields a genetic covariance matrix of dimension equal to the number of countries which typically involves high genetic correlations between countries. This gives rise to several problems such as over-parameterized models and increased sampling variances, if genetic (covariance matrices are considered to be unstructured. Methods Principal component (PC and factor analytic (FA models allow highly parsimonious representations of the (covariance matrix compared to the standard multi-trait model and have, therefore, attracted considerable interest for their potential to ease the burden of the estimation process for multiple-trait across country evaluation (MACE. This study evaluated the utility of PC and FA models to estimate variance components and to predict breeding values for MACE for protein yield. This was tested using a dataset comprising Holstein bull evaluations obtained in 2007 from 25 countries. Results In total, 19 principal components or nine factors were needed to explain the genetic variation in the test dataset. Estimates of the genetic parameters under the optimal fit were almost identical for the two approaches. Furthermore, the results were in a good agreement with those obtained from the full rank model and with those provided by Interbull. The estimation time was shortest for models fitting the optimal number of parameters and prolonged when under- or over-parameterized models were applied. Correlations between estimated breeding values (EBV from the PC19 and PC25 were unity. With few exceptions, correlations between EBV obtained using FA and PC approaches under the optimal fit were

  19. Issues in Value-at-Risk Modeling and Evaluation

    NARCIS (Netherlands)

    J. Danielsson; C.G. de Vries (Casper); B.N. Jorgensen (Bjørn); P.F. Christoffersen (Peter); F.X. Diebold (Francis); T. Schuermann (Til); J.A. Lopez (Jose); B. Hirtle (Beverly)

    1998-01-01

    textabstractDiscusses the issues in value-at-risk modeling and evaluation. Value of value at risk; Horizon problems and extreme events in financial risk management; Methods of evaluating value-at-risk estimates.

  20. Comparison of multiplicative heterogeneous variance adjustment models for genetic evaluations.

    Science.gov (United States)

    Márkus, Sz; Mäntysaari, E A; Strandén, I; Eriksson, J-Å; Lidauer, M H

    2014-06-01

    Two heterogeneous variance adjustment methods and two variance models were compared in a simulation study. The method used for heterogeneous variance adjustment in the Nordic test-day model, which is a multiplicative method based on Meuwissen (J. Dairy Sci., 79, 1996, 310), was compared with a restricted multiplicative method where the fixed effects were not scaled. Both methods were tested with two different variance models, one with a herd-year and the other with a herd-year-month random effect. The simulation study was built on two field data sets from Swedish Red dairy cattle herds. For both data sets, 200 herds with test-day observations over a 12-year period were sampled. For one data set, herds were sampled randomly, while for the other, each herd was required to have at least 10 first-calving cows per year. The simulations supported the applicability of both methods and models, but the multiplicative mixed model was more sensitive in the case of small strata sizes. Estimation of variance components for the variance models resulted in different parameter estimates, depending on the applied heterogeneous variance adjustment method and variance model combination. Our analyses showed that the assumption of a first-order autoregressive correlation structure between random-effect levels is reasonable when within-herd heterogeneity is modelled by year classes, but less appropriate for within-herd heterogeneity by month classes. Of the studied alternatives, the multiplicative method and a variance model with a random herd-year effect were found most suitable for the Nordic test-day model for dairy cattle evaluation.

  1. The establishment of the evaluation model for pupil's lunch suppliers

    Science.gov (United States)

    Lo, Chih-Yao; Hou, Cheng-I.; Ma, Rosa

    2011-10-01

    The aim of this study is the establishment of the evaluation model for the government-controlled private suppliers for school lunches in the public middle and primary schools in Miao-Li County. After finishing the literature search and the integration of the opinions from anonymous experts by Modified Delphi Method, the grade forms from relevant schools in and outside the Miao-Li County will firstly be collected and the delaminated structures for evaluation be constructed. Then, the data analysis will be performed on those retrieved questionnaires designed in accordance with the Analytic Hierarchy Process (AHP). Finally, the evaluation form for the government-controlled private suppliers can be constructed and presented in the hope of benefiting the personnel in charge of school meal purchasing.

  2. FUZZY COMPREHENSIVE EVALUATION MODEL OF ECOLOGICAL DEMONSTRATION AREA

    Institute of Scientific and Technical Information of China (English)

    YU Ya-juan; GUO Huai-cheng; LIU Yong; WANG Shu-tong; WANG Jin-feng

    2005-01-01

    Ecological demonstration area (EDA) is an authorized nomination, which should be assessed from several aspects, including ecological, social, environmental, economic ones and so on. It is difficult to advance an exact developing level index of EDA due to its indicator system's complexity and disequilibrium. In this paper, a framework of indicators was set to evaluate, monitor and examine the comprehensive level of ecological demonstration area (EDA). Fuzzy logic method was used to develop the fuzzy comprehensive evaluation model (FCEM), which could quantitatively reveal the developing degree of EDA. Huiji District of Zhengzhou, Henan Province, one of the 9th group of national EDAs, was taken as a study case. The framework of FCEM for the integrated system included six subsystems, which were social, economic, ecological, rural, urban and accessorial description ones. The research would be valuable in the comprehensive quantitative evaluation of EDA and would work as a guide in the construction practices of Huiji ecological demonstration area.

  3. Evaluating Vocational Programs: A Three Dimensional Model.

    Science.gov (United States)

    Rehman, Sharaf N.; Nejad, Mahmoud

    The traditional methods of assessing the academic programs in the liberal arts are inappropriate for evaluating vocational and technical programs. In traditional academic disciplines, assessment of instruction is conducted in two fashions: student evaluation at the end of a course and institutional assessment of its goals and mission. Because of…

  4. Doctoral Dissertation Supervision: Identification and Evaluation of Models

    Directory of Open Access Journals (Sweden)

    Ngozi Agu

    2014-01-01

    Full Text Available Doctoral research supervision is one of the major avenues for sustaining students’ satisfaction with the programme, preparing students to be independent researchers and effectively initiating students into the academic community. This work reports doctoral students’ evaluation of their various supervision models, their satisfaction with these supervision models, and development of research-related skills. The study used a descriptive research design and was guided by three research questions and two hypotheses. A sample of 310 Ph.D. candidates drawn from a federal university in Eastern part of Nigeria was used for this study. The data generated through the questionnaire was analyzed using descriptive statistics and t-tests. Results show that face-to-face interactive model was not only the most frequently used, but also the most widely adopted in doctoral thesis supervision while ICT-based models were rarely used. Students supervised under face-to-face interactive model reported being more satisfied with dissertation supervision than those operating under face-to-face noninteractive model. However, students supervised under these two models did not differ significantly in their perceived development in research-related skills.

  5. Evaluation of ASTER and SRTM DEM data for lahar modeling: A case study on lahars from Popocatépetl Volcano, Mexico

    OpenAIRE

    2008-01-01

    Lahars are among themost serious and far-reaching volcanic hazards. In regions with potential interactions of lahars with populated areas and human structures the assessment of the related hazards is crucial for undertaking appropriate mitigating actions and reduce the associated risks. Modeling of lahars has become an important tool in such assessments, in particular where the geologic record of past events is insufficient. Mass-flow modeling strongly relies on digital terrain data. Availabi...

  6. Modeling and Evaluating Emotions Impact on Cognition

    Science.gov (United States)

    2013-07-01

    International Conference on Automatic Face and Gesture Recognition . Shanghai, China, April 2013 • Wenji Mao and Jonathan Gratch. Modeling Social...Modeling, Lorentz Center, Leiden. August 2011 • Keynote speaker, IEEE International Conference on Automatic Face and Gesture Recognition , Santa

  7. Statistical models of shape optimisation and evaluation

    CERN Document Server

    Davies, Rhodri; Taylor, Chris

    2014-01-01

    Deformable shape models have wide application in computer vision and biomedical image analysis. This book addresses a key issue in shape modelling: establishment of a meaningful correspondence between a set of shapes. Full implementation details are provided.

  8. SIMPLEBOX: a generic multimedia fate evaluation model

    NARCIS (Netherlands)

    Meent D van de

    1993-01-01

    This document describes the technical details of the multimedia fate model SimpleBox, version 1.0 (930801). SimpleBox is a multimedia box model of what is commonly referred to as a "Mackay-type" model ; it assumes spatially homogeneous environmental compartments (air, water, suspended matter, aquati

  9. SIMPLEBOX: a generic multimedia fate evaluation model

    NARCIS (Netherlands)

    van de Meent D

    1993-01-01

    This document describes the technical details of the multimedia fate model SimpleBox, version 1.0 (930801). SimpleBox is a multimedia box model of what is commonly referred to as a "Mackay-type" model ; it assumes spatially homogeneous environmental compartments (air, water, suspended m

  10. Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study

    Directory of Open Access Journals (Sweden)

    Kang Yoon-Jung

    2011-06-01

    Full Text Available Abstract Background A new lower-cost rapid-throughput human papillomavirus (HPV test (careHPV, Qiagen, Gaithersburg, USA has been shown to have high sensitivity for the detection of high grade cervical intraepithelial neoplasia. Methods We assessed the outcomes and cost-effectiveness of careHPV screening in rural China, compared to visual inspection with acetic acid, when used alone (VIA or in combination with Lugol's iodine (VIA/VILI. Using data on sexual behaviour, test accuracy, diagnostic practices and costs from studies performed in rural China, we estimated the cost-effectiveness ratio (CER and associated lifetime outcomes for once-lifetime and twice-lifetime screening strategies, and for routine screening at 5-yearly, 10-yearly and IARC-recommended intervals. The optimal age range for once-lifetime screening was also assessed. Results For all strategies, the relative ordering of test technologies in reducing cervical cancer incidence and mortality was VIA (least effective; VIA/VILI; careHPV@1.0 pg/ml and careHPV@0.5 pg/ml (most effective. For once-lifetime strategies, maximum effectiveness was achieved if screening occurred between 35-50 years. Assuming a participation rate of ~70%, once-lifetime screening at age 35 years would reduce cancer mortality by 8% (for VIA to 12% (for careHPV@0.5 over the long term, with a CER of US$557 (for VIA to $959 (for careHPV@1.0 per life year saved (LYS compared to no intervention; referenced to a 2008 GDP per capita in Shanxi Province of $2,975. Correspondingly, regular screening with an age-standardised participation rate of 62% (which has been shown to be achievable in this setting would reduce cervical cancer mortality by 19-28% (for 10-yearly screening to 43-54% (using IARC-recommended intervals, with corresponding CERs ranging from $665 (for 10-yearly VIA to $2,269 (for IARC-recommended intervals using careHPV@1.0 per LYS. Conclusions This modelled analysis suggests that primary careHPV screening

  11. Evaluation of the Titan2D two-phase flow model using an actual event: Case study of the 2005 Vazcún Valley Lahar

    Science.gov (United States)

    Williams, R.; Stinton, A. J.; Sheridan, M. F.

    2008-11-01

    Titan2D is a depth-averaged, thin-layer computational fluid dynamics (CFD) code, suitable for simulating a variety of geophysical mass flows. Titan2D output data include flow thickness and flow momentum at each time step for all cells traversed by the flow during the simulation. From this information the flow limit, run-out path, flow velocity, deposit thickness, and travel time can be calculated. Results can be visualized in the open-source GRASS GIS software or with the built-in Titan2D viewer. A new two-phase Titan2D version allows simulation of flows containing various mixtures of water and solids. The purpose of this study is to compare simulations by the two-phase flow version of Titan2D with an actual event. The chosen natural flow is a small ash-rich lahar (volume 50,000 m 3-70,000 m 3) that occurred on 12 February 2005 in the Vazcún Valley, located on the north-east flank of Volcán Tungurahua, Ecuador. Lahars and pyroclastic flows along this valley could potentially threaten the 20,000 inhabitants living in and near the city of Baños. A variety of data sources exist for this lahar, including: post-event meter-scale topography, and photographic, video, seismic and acoustic flow monitoring (AFM) records from during the event. These data permit detailed comparisons between the dynamics of the actual lahar and those of the Titan2D simulated flow. In particular, detailed comparisons are made between run-up heights, flow velocity, inundation area, and flow thickness. Simulations utilize a variety of data derived from field observations such as lahar volume, solid to pore-fluid ratio and pre-event topography. Titan2D is important in modeling lahars because it allows assessment of the impact of the flows on buildings and infrastructure lifelines located near drainages that descend from volcanoes.

  12. MODEL-BASED PERFORMANCE EVALUATION APPROACH FOR MOBILE AGENT SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    Li Xin; Mi Zhengkun; Meng Xudong

    2004-01-01

    Claimed as the next generation programming paradigm, mobile agent technology has attracted extensive interests in recent years. However, up to now, limited research efforts have been devoted to the performance study of mobile agent system and most of these researches focus on agent behavior analysis resulting in that models are hard to apply to mobile agent systems. To bridge the gap, a new performance evaluation model derived from operation mechanisms of mobile agent platforms is proposed. Details are discussed for the design of companion simulation software, which can provide the system performance such as response time of platform to mobile agent. Further investigation is followed on the determination of model parameters. Finally comparison is made between the model-based simulation results and measurement-based real performance of mobile agent systems. The results show that the proposed model and designed software are effective in evaluating performance characteristics of mobile agent systems. The proposed approach can also be considered as the basis of performance analysis for large systems composed of multiple mobile agent platforms.

  13. Integrating fire with hydrological projections: model evaluation to identify uncertainties and tradeoffs in model complexity

    Science.gov (United States)

    Kennedy, M.; McKenzie, D.

    2013-12-01

    It is imperative for resource managers to understand how a changing climate might modify future watershed and hydrological processes, and such an understanding is incomplete if disturbances such as fire are not integrated with hydrological projections. Can a robust fire spread model be developed that approximates patterns of fire spread in response to varying topography wind patterns, and fuel loads and moistures, without requiring intensive calibration to each new study area or time frame? We assessed the performance of a stochastic model of fire spread (WMFire), integrated with the Regional Hydro-Ecological Simulation System (RHESSys), for projecting the effects of climatic change on mountain watersheds. We first use Monte Carlo inference to determine that the fire spread model is able to replicate the spatial pattern of fire spread for a contemporary wildfire in Washington State (the Tripod fire), measured by the lacunarity and fractal dimension of the fire. We then integrate a version of WMFire able to replicate the contemporary wildfire with RHESSys and simulate a New Mexico watershed over the calibration period of RHESSys (1941-1997). In comparing the fire spread model to a single contemporary wildfire we found issues in parameter identifiability for several of the nine parameters, due to model input uncertainty and insensitivity of the mathematical function to certain ranges of the parameter values. Model input uncertainty is caused by the inherent difficulty in reconstructing fuel loads and fuel moistures for a fire event after the fire has occurred, as well as by issues in translating variables relevant to hydrological processes produced by the hydrological model to those known to affect fire spread and fire severity. The first stage in the model evaluation aided the improvement of the model in both of these regards. In transporting the model to a new landscape in order to evaluate fire regimes in addition to patterns of fire spread, we find reasonable

  14. Study on Rational Irrigation for Wheat Production in Fengqiu Region:Ⅱ.A Model of Rational Irrigation for Wheat and Its Evaluation

    Institute of Scientific and Technical Information of China (English)

    ZHOULINGYUN; CHENZHIXIONG

    1997-01-01

    A 5-year experiment on water balance was conducted in a flat rainfed wheat field with area of 66 m×100m in Fengqiu,Henan Province,China,Based on the results of the 5-consecutive-year experiments,a reasonable irrigation model for wheat cultivation is suggested according to the principle of maintaining balance of the water resources.The irrigation program was designed by simulting the ideal soil moisure regimes during a wheat season.As far as the actual soil moisture was concered,its deviation from the ideal soil moisture was kept within ±50 nm ,If this model was put into practice,a grain yield of 5 250kg ha-1 could be expected under optimal fertiliztion.Compared with the traditonal irrigation scheme,the suggested model saved irrigation water by 18%.

  15. Probability distribution analysis of observational extreme events and model evaluation

    Science.gov (United States)

    Yu, Q.; Lau, A. K. H.; Fung, J. C. H.; Tsang, K. T.

    2016-12-01

    Earth's surface temperatures were the warmest in 2015 since modern record-keeping began in 1880, according to the latest study. In contrast, a cold weather occurred in many regions of China in January 2016, and brought the first snowfall to Guangzhou, the capital city of Guangdong province in 67 years. To understand the changes of extreme weather events as well as project its future scenarios, this study use statistical models to analyze on multiple climate data. We first use Granger-causality test to identify the attribution of global mean temperature rise and extreme temperature events with CO2 concentration. The four statistical moments (mean, variance, skewness, kurtosis) of daily maximum temperature distribution is investigated on global climate observational, reanalysis (1961-2010) and model data (1961-2100). Furthermore, we introduce a new tail index based on the four moments, which is a more robust index to measure extreme temperatures. Our results show that the CO2 concentration can provide information to the time series of mean and extreme temperature, but not vice versa. Based on our new tail index, we find that other than mean and variance, skewness is an important indicator should be considered to estimate extreme temperature changes and model evaluation. Among the 12 climate model data we investigate, the fourth version of Community Climate System Model (CCSM4) from National Center for Atmospheric Research performs well on the new index we introduce, which indicate the model have a substantial capability to project the future changes of extreme temperature in the 21st century. The method also shows its ability to measure extreme precipitation/ drought events. In the future we will introduce a new diagram to systematically evaluate the performance of the four statistical moments in climate model output, moreover, the human and economic impacts of extreme weather events will also be conducted.

  16. Methodology using a portable X-ray fluorescence device for on-site and rapid evaluation of heavy-atom contamination in wounds: a model study for application to pluton