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Sample records for modeling studies related

  1. The Social Relations Model in Family Studies: A Systematic Review

    Science.gov (United States)

    Eichelsheim, Veroni I.; Dekovic, Maja; Buist, Kirsten L.; Cook, William L.

    2009-01-01

    The Social Relations Model (SRM) allows for examination of family relations on three different levels: the individual level (actor and partner effects), the dyadic level (relationship effects), and the family level (family effect). The aim of this study was to present a systematic review of SRM family studies and identify general patterns in the…

  2. Models as Relational Categories

    Science.gov (United States)

    Kokkonen, Tommi

    2017-11-01

    Model-based learning (MBL) has an established position within science education. It has been found to enhance conceptual understanding and provide a way for engaging students in authentic scientific activity. Despite ample research, few studies have examined the cognitive processes regarding learning scientific concepts within MBL. On the other hand, recent research within cognitive science has examined the learning of so-called relational categories. Relational categories are categories whose membership is determined on the basis of the common relational structure. In this theoretical paper, I argue that viewing models as relational categories provides a well-motivated cognitive basis for MBL. I discuss the different roles of models and modeling within MBL (using ready-made models, constructive modeling, and generative modeling) and discern the related cognitive aspects brought forward by the reinterpretation of models as relational categories. I will argue that relational knowledge is vital in learning novel models and in the transfer of learning. Moreover, relational knowledge underlies the coherent, hierarchical knowledge of experts. Lastly, I will examine how the format of external representations may affect the learning of models and the relevant relations. The nature of the learning mechanisms underlying students' mental representations of models is an interesting open question to be examined. Furthermore, the ways in which the expert-like knowledge develops and how to best support it is in need of more research. The discussion and conceptualization of models as relational categories allows discerning students' mental representations of models in terms of evolving relational structures in greater detail than previously done.

  3. Developmental Relations between Vocabulary Knowledge and Reading Comprehension: A Latent Change Score Modeling Study

    Science.gov (United States)

    Quinn, Jamie M.; Wagner, Richard K.; Petscher, Yaacov; Lopez, Danielle

    2015-01-01

    The present study followed a sample of first-grade (N = 316, M[subscript age] = 7.05 at first test) through fourth-grade students to evaluate dynamic developmental relations between vocabulary knowledge and reading comprehension. Using latent change score modeling, competing models were fit to the repeated measurements of vocabulary knowledge and…

  4. Relational Understanding of the Derivative Concept through Mathematical Modeling: A Case Study

    Science.gov (United States)

    Sahin, Zulal; Aydogan Yenmez, Arzu; Erbas, Ayhan Kursat

    2015-01-01

    The purpose of this study was to investigate three second-year graduate students' awareness and understanding of the relationships among the "big ideas" that underlie the concept of derivative through modeling tasks and Skemp's distinction between relational and instrumental understanding. The modeling tasks consisting of warm-up,…

  5. Animal models for the study of hepatitis C virus infection and related liver disease

    DEFF Research Database (Denmark)

    Bukh, Jens

    2012-01-01

    Hepatitis C virus (HCV) causes liver-related death in more than 300,000 people annually. Treatments for patients with chronic HCV are suboptimal, despite the introduction of directly acting antiviral agents. There is no vaccine that prevents HCV infection. Relevant animal models are important...... for HCV research and development of drugs and vaccines. Chimpanzees are the best model for studies of HCV infection and related innate and adaptive host immune responses. They can be used in immunogenicity and efficacy studies of HCV vaccines. The only small animal models of robust HCV infection are T...

  6. Developmental relations between vocabulary knowledge and reading comprehension: a latent change score modeling study.

    Science.gov (United States)

    Quinn, Jamie M; Wagner, Richard K; Petscher, Yaacov; Lopez, Danielle

    2015-01-01

    The present study followed a sample of first-grade (N = 316, Mage = 7.05 at first test) through fourth-grade students to evaluate dynamic developmental relations between vocabulary knowledge and reading comprehension. Using latent change score modeling, competing models were fit to the repeated measurements of vocabulary knowledge and reading comprehension to test for the presence of leading and lagging influences. Univariate models indicated growth in vocabulary knowledge, and reading comprehension was determined by two parts: constant yearly change and change proportional to the previous level of the variable. Bivariate models indicated previous levels of vocabulary knowledge acted as leading indicators of reading comprehension growth, but the reverse relation was not found. Implications for theories of developmental relations between vocabulary and reading comprehension are discussed. © 2014 The Authors. Child Development © 2014 Society for Research in Child Development, Inc.

  7. Establishing a common ground for the use of structural equation modelling for construction related research studies

    Directory of Open Access Journals (Sweden)

    Ayodeji Emmanuel Oke

    2012-09-01

    Full Text Available The use of structural equation modelling (SEM for research studies in construction related field has been on the increase over the years. The essence of this study is not to compare the level of usage of SEM with other modelling methods, neither is it to examine its extent of adoption in construction management - as this has been researched in previous works - but to arrive at a common ground for future construction related research works, based on the findings and recommendations from existing studies on the subject of SEM. Research materials within and outside the field of construction management were reviewed and it was discovered that SEM using AMOS (covariance approach is the most appropriate method for construction research studies. This is not just because it is the most available of the software programs, but because of the numerous benefits and advantages highlighted from previous studies. The study also recommended appropriate sample size as well as cut-off value for various required goodness-of-fit tests of SEM model.

  8. A Bigraph Relational Model

    DEFF Research Database (Denmark)

    Beauquier, Maxime; Schürmann, Carsten

    2011-01-01

    In this paper, we present a model based on relations for bigraphical reactive system [Milner09]. Its defining characteristics are that validity and reaction relations are captured as traces in a multi-set rewriting system. The relational model is derived from Milner's graphical definition...

  9. PET studies in nonhuman primate models of cocaine abuse: translational research related to vulnerability and neuroadaptations.

    Science.gov (United States)

    Gould, Robert W; Duke, Angela N; Nader, Michael A

    2014-09-01

    The current review highlights the utility of positron emission tomography (PET) imaging to study the neurobiological substrates underlying vulnerability to cocaine addiction and subsequent adaptations following chronic cocaine self-administration in nonhuman primate models of cocaine abuse. Environmental (e.g., social rank) and sex-specific influences on dopaminergic function and sensitivity to the reinforcing effects of cocaine are discussed. Cocaine-related cognitive deficits have been hypothesized to contribute to high rates of relapse and are described in nonhuman primate models. Lastly, the long-term consequences of cocaine on neurobiology are discussed. PET imaging and longitudinal, within-subject behavioral studies in nonhuman primates have provided a strong framework for designing pharmacological and behavioral treatment strategies to aid drug-dependent treatment seekers. Non-invasive PET imaging will allow for individualized treatment strategies. Recent advances in radiochemistry of novel PET ligands and other imaging modalities can further advance our understanding of stimulant use on the brain. This article is part of the Special Issue Section entitled 'Neuroimaging in Neuropharmacology'. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. Modelling dense relational data

    DEFF Research Database (Denmark)

    Herlau, Tue; Mørup, Morten; Schmidt, Mikkel Nørgaard

    2012-01-01

    Relational modelling classically consider sparse and discrete data. Measures of influence computed pairwise between temporal sources naturally give rise to dense continuous-valued matrices, for instance p-values from Granger causality. Due to asymmetry or lack of positive definiteness they are no......Relational modelling classically consider sparse and discrete data. Measures of influence computed pairwise between temporal sources naturally give rise to dense continuous-valued matrices, for instance p-values from Granger causality. Due to asymmetry or lack of positive definiteness...... they are not naturally suited for kernel K-means. We propose a generative Bayesian model for dense matrices which generalize kernel K-means to consider off-diagonal interactions in matrices of interactions, and demonstrate its ability to detect structure on both artificial data and two real data sets....

  11. Use of Invasion Percolation Models To Study the Secondary Migration of Oil and Related Problems

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, G.

    1997-12-31

    This thesis studies simulations of the slow displacement of a wetting fluid by a non-wetting fluid in porous media and in a single fracture. The simulations are based on the invasion percolation model. New modified versions of the model are presented that simulate migration, fragmentation and coalescence processes of the clusters of non-wetting fluid. The resulting displacement patterns are characterized by scaling laws. In particular, simulations of the secondary migration of oil through porous homogeneous rock are discussed. Fractured rocks are extreme cases of inhomogeneous porous media. Simulations of the slow displacement of a wetting fluid by a non-wetting fluid in a single fracture using the standard invasion model are presented. There is a discussion of a scenario in which a cluster of non-wetting fluid migrates through a porous medium that was saturated with a wetting fluid. The migration is driven by continuously driven buoyancy forces. Both experiments and simulations are described. The same scenario is also studied theoretically and by simulations using a simplified percolation model of fluid migration in one dimension. The migration model in two dimensions, with constant buoyancy forces, is also discussed. Simulations of fluid migration, such as the secondary migration of oil, in two- and three-dimensional media are examined, the media having multi-affine properties rather than being homogeneous. Slow immiscible displacement processes in single fractures are studied using fractal geometries to model single fractures. 167 refs., 123 figs.

  12. Studying Sex Differences in Animal Models of Addiction: An Emphasis on Alcohol-Related Behaviors.

    Science.gov (United States)

    Hilderbrand, Elisa R; Lasek, Amy W

    2017-12-26

    Animal models are essential for understanding the biological factors that contribute to drug and alcohol addiction and discovering new pharmacotherapies to treat these disorders. Alcohol (ethanol) is the most commonly abused drug in the world, and as the prevalence of alcohol use disorder (AUD) increases, so does the need for effective pharmacotherapies. In particular, treatments with high efficacy in the growing number of female AUD sufferers are needed. Female animals remain underrepresented in biomedical research and sex differences in the brain's response to alcohol are poorly understood. To help bridge the gender gap in addiction research, this Review discusses strategies that researchers can use to examine sex differences in the context of several common animal models of AUD. Self-administration, two-bottle choice, drinking in the dark, and conditioned place preference are discussed, with a focus on the role of estrogen as a mediator of sex differences in alcohol-related behaviors.

  13. How the formation of amyloid plaques and neurofibrillary tangles may be related: a mathematical modelling study

    Science.gov (United States)

    Kuznetsov, I. A.; Kuznetsov, A. V.

    2018-02-01

    We develop a mathematical model that enables us to investigate possible mechanisms by which two primary markers of Alzheimer's disease (AD), extracellular amyloid plaques and intracellular tangles, may be related. Our model investigates the possibility that the decay of anterograde axonal transport of amyloid precursor protein (APP), caused by toxic tau aggregates, leads to decreased APP transport towards the synapse and APP accumulation in the soma. The developed model thus couples three processes: (i) slow axonal transport of tau, (ii) tau misfolding and agglomeration, which we simulated by using the Finke-Watzky model and (iii) fast axonal transport of APP. Because the timescale for tau agglomeration is much larger than that for tau transport, we suggest using the quasi-steady-state approximation for formulating and solving the governing equations for these three processes. Our results suggest that misfolded tau most likely accumulates in the beginning of the axon. The analysis of APP transport suggests that APP will also likely accumulate in the beginning of the axon, causing an increased APP concentration in this region, which could be interpreted as a `traffic jam'. The APP flux towards the synapse is significantly reduced by tau misfolding, but not due to the APP traffic jam, which can be viewed as a symptom, but rather due to the reduced affinity of kinesin-1 motors to APP-transporting vesicles.

  14. Culture-related service expectations: a comparative study using the Kano model.

    Science.gov (United States)

    Hejaili, Fayez F; Assad, Lina; Shaheen, Faissal A; Moussa, Dujana H; Karkar, Ayman; AlRukhaimi, Mona; Barhamein, Majdah; Al Suwida, Abdulkareem; Al Alhejaili, Faris F; Al Harbi, Ali S; Al Homrany, Mohamed; Attar, Bisher; Al-Sayyari, Abdulla A

    2009-01-01

    To compare service expectations between Arab and Austrian patients. We used a Kano model-based questionnaire with 20 service attributes of relevance to the dialysis patient. We analyzed 530, 172, 60, and 68 responses from Saudi, Austrian, Syrian, and UAE patients, respectively. We compared the customer satisfaction coefficient and the frequencies of response categories ("must be," "attractive," "one-dimensional," and "indifferent") for each of the 20 service attributes and in each of the 3 national groups of patients. We also investigated whether any differences seen were related to sex, age, literacy rate, or duration on dialysis. We observed higher satisfaction coefficients and "one-directional" responses among Arab patients and higher dissatisfaction coefficients and "must be" and "attractive" responses among Austrian patients. These were not related to age or duration on dialysis but were related to literacy rate. We speculate that these discrepancies between Austrian and Arab patients might be related to underdeveloped sophistication in market competitive forces and to cultural influences.

  15. A model study on color and related structural properties of cured porcine batters

    NARCIS (Netherlands)

    Palombo, R.

    1990-01-01

    Color, determined by tristimulus colorimeters, and related structural properties, i.e., microstructure, surface rheology, and bulk rheology, of cured porcine meat batters were studied.

    Effects of various processing factors (such as, temperature, air pressure during chopping, and

  16. Stress-Related Alterations of Visceral Sensation: Animal Models for Irritable Bowel Syndrome Study

    Science.gov (United States)

    Mulak, Agata; Taché, Yvette

    2011-01-01

    Stressors of different psychological, physical or immune origin play a critical role in the pathophysiology of irritable bowel syndrome participating in symptoms onset, clinical presentation as well as treatment outcome. Experimental stress models applying a variety of acute and chronic exteroceptive or interoceptive stressors have been developed to target different periods throughout the lifespan of animals to assess the vulnerability, the trigger and perpetuating factors determining stress influence on visceral sensitivity and interactions within the brain-gut axis. Recent evidence points towards adequate construct and face validity of experimental models developed with respect to animals' age, sex, strain differences and specific methodological aspects such as non-invasive monitoring of visceromotor response to colorectal distension as being essential in successful identification and evaluation of novel therapeutic targets aimed at reducing stress-related alterations in visceral sensitivity. Underlying mechanisms of stress-induced modulation of visceral pain involve a combination of peripheral, spinal and supraspinal sensitization based on the nature of the stressors and dysregulation of descending pathways that modulate nociceptive transmission or stress-related analgesic response. PMID:21860814

  17. Model Management Intergovernmental Relations Case Study Program Free Education In South Sulawesi

    Directory of Open Access Journals (Sweden)

    Suhardiman Syamsu

    2015-01-01

    Full Text Available Abstract Looking for intergovernmental relations management model is a consequence of the decentralization of government from local to central government provincial and district city. Delivery of affairs to the position of actors in the region more involved than ever before. The actor was instrumental in determining the center of attention authority patterns and methods of conflict resolution when to initiate and conduct a free educational program cooperation. Intergovernmental relations management effectiveness is determined by the role of actors in determining the center of attention establish a pattern of authority and choose a method of conflict resolution. Affairs of primary and secondary education is the authority of the district city. If the provincial government to initiate treatment in the free education program the pattern of intergovernmental relations management authority selected cooperation may or may be of assistance subsidy. For matters of primary and secondary education the choice of co-administration is not appropriate. Choices made during this cooperation needs to be reviewed with due regard to equality work together mutual benefit of all parties cooperate. When cooperation to lead to conflicts preferably selected pattern of relationships is the only province to provide subsidies allow the district city alone is conducting the affairs of a free education. Options cooperation dominated by actors and actors governor regent mayor refused to put forward its own program is an option for power from the owner of the sovereignty of the people as a constituent in the local elections in both provinces and districts cities.

  18. Wind farm related mortality among avian migrants - a remote sensing study and model analysis

    DEFF Research Database (Denmark)

    Desholm, M.

    -2006) of migrating birds at the Nysted offshore wind farm in the Baltic Sea, Denmark. This thesis poses and answers the following questions: a) what hazard factors do offshore wind farming pose to wild birds, b) how should one choose the key focal species to study, c) how can remote sensing techniques be applied......This thesis is the result of a PhD study on bird-wind farm collisions and consists of a synopsis, five published papers, one submitted manuscript and another ready for submission. The papers describe the fi ndings from pre- and post-construction visual, radar and thermal imaging studies (1999...... to the study of bird wind farm interactions, and d) specifi cally, how do waterbirds react when approaching an offshore wind farm? The main aim of the study was the development of a predictive bird-wind farm collision model that incorporates the avoidance rate of birds at multiple scales. Out of 235...

  19. Wind farm related mortality among avian migrants - a remote sensing study and model analysis

    Energy Technology Data Exchange (ETDEWEB)

    Desholm, M.

    2006-11-15

    This thesis is the result of a PhD study on bird-wind farm collisions and consists of a synopsis, five published papers, one submitted manuscript and another ready for submission. The papers describe the findings from pre- and post-construction visual, radar and thermal imaging studies (1999-2006) of migrating birds at the Nysted offshore wind farm in the Baltic Sea, Denmark. This thesis poses and answers the following questions: a) what hazard factors do offshore wind farming pose to wild birds, b) how should one choose the key focal species to study, c) how can remote sensing techniques be applied to the study of bird wind farm interactions, and d) specifically, how do water birds react when approaching an offshore wind farm? The main aim of the study was the development of a predictive bird-wind farm collision model that incorporates the avoidance rate of birds at multiple scales. Out of 235,136 migrating sea ducks only 47 individuals were predicted to collide with the wind turbine rotor-blades, equivalent to an overall mean collision risk of c. 0.02%. This thesis shows the added value of modelling in supplementing sound empirical studies in accessing the effects of major human development pressures on migratory bird populations. (au)

  20. Personal Influence Model of Public Relations: A Case Study in Indonesia’s Mining Industry

    Directory of Open Access Journals (Sweden)

    Gregoria Arum Yudarwati

    2013-11-01

    Full Text Available Abstract: Studi kasus di industri pertambangan Indonesia dipilih sebagai jendela untuk memahami fungsi public relations (PR di era paska Suharto. Partisipan memandang era reformasi yang memungkinkan kebebasan berpendapat dan sistem desentralisasi sebagai pemicu untuk menyusun strategi public relations (PR yang baru dalam menjalin hubungan dengan publik. Personal relationship model of PR ditemukan sebagai model PR yang dominan di industri pertambangan Indonesia. Model ini dipilih sebagai strategi untuk membangun hubungan baik dengan orangorang kunci di komunitas yang dipahami sebagai masyarakat kolektif. Temuan ini mendukung proposisi yang menyatakan adanya pengaruh budaya setempat dan nilai-nilai lokal terhadap paktekPR.

  1. Use of Invasion Percolation Models To Study the Secondary Migration of Oil and Related Problems

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, G.

    1997-09-01

    In oil reservoir engineering, multi-phase displacement processes are important. This doctoral thesis describes simulations of the slow displacement of a wetting fluid by a non-wetting fluid in a complex, random porous medium and in a single fracture. The study is restricted to two-phase flow in the quasi-static limit in which viscous forces can be neglected. The secondary migration of oil takes place in this regime, however, the discussion is broader in scope. The thesis connects the problem of slow two-phase flow to percolation theory and discusses the mechanisms that control immiscible displacements. A new, modified version of the invasion percolation model is used to simulate an imbibition process in a porous medium and the migration of a cluster of non-wetting fluid through a porous medium saturated with a wetting fluid. The simulations include the secondary migration of oil through porous homogeneous rock. Fluid migration through heterogeneous porous media is simulated qualitatively. Slow displacement of a wetting fluid by a non-wetting fluid in a single rock fracture is simulated by using the standard invasion percolation model. Experiments and simulations are performed to study the fragmentation of invasion percolation-like structures of non-wetting fluid in a porous medium saturated with a wetting fluid. A scenario is studied in which a cluster of non-wettable fluid migrates through a porous medium that is saturated with a wetting fluid, the migration being driven by continuously increasing buoyancy forces. There is a simulation of the secondary migration of oil in both two- and three-dimensional media. 361 refs., 115 figs.

  2. Strengths and Limitations of Model Systems for the Study of Urinary Tract Infections and Related Pathologies

    Science.gov (United States)

    Barber, Amelia E.; Norton, J. Paul; Wiles, Travis J.

    2016-01-01

    SUMMARY Urinary tract infections (UTIs) are some of the most common bacterial infections worldwide and are a source of substantial morbidity among otherwise healthy women. UTIs can be caused by a variety of microbes, but the predominant etiologic agent of these infections is uropathogenic Escherichia coli (UPEC). An especially troubling feature of UPEC-associated UTIs is their high rate of recurrence. This problem is compounded by the drastic increase in the global incidence of antibiotic-resistant UPEC strains over the past 15 years. The need for more-effective treatments for UTIs is driving research aimed at bettering our understanding of the virulence mechanisms and host-pathogen interactions that occur during the course of these infections. Surrogate models of human infection, including cell culture systems and the use of murine, porcine, avian, teleost (zebrafish), and nematode hosts, are being employed to define host and bacterial factors that modulate the pathogenesis of UTIs. These model systems are revealing how UPEC strains can avoid or overcome host defenses and acquire scarce nutrients while also providing insight into the virulence mechanisms used by UPEC within compromised individuals, such as catheterized patients. Here, we summarize our current understanding of UTI pathogenesis while also giving an overview of the model systems used to study the initiation, persistence, and recurrence of UTIs and life-threatening sequelae like urosepsis. Although we focus on UPEC, the experimental systems described here can also provide valuable insight into the disease processes associated with other bacterial pathogens both within the urinary tract and elsewhere within the host. PMID:26935136

  3. Radionuclide migration experiments related to an underground nuclear test: II. modeling studies

    International Nuclear Information System (INIS)

    Tompson, A.; Carle, S.F.; Smith, D.K.; Hudson, G.B.; Bruton, C.J.

    2001-01-01

    Full text: The goal of this project is to improve our understanding of water and radionuclide migration in both saturated and unsaturated geologic media by coupling advanced simulation techniques, available characterization data, and radioanalytical measurements in the context of a remarkable field experiment. Between 1975 and 1991, groundwater was steadily pumped from a well adjacent to a 1965 underground test conducted in alluvium at the Nevada Test Site. The experiment was primarily conducted in order to elicit information on radionuclide migration through the saturated zone between the test and the well. The effluent was monitored. discharged to an unlined ditch, and allowed to infiltrate into the ground during flow towards a dry lake, about a kilometer away. The 16 years of pumping and infiltration created an unexpected second experiment in which the migration of the ditch effluent through the 200 meters of unsaturated media, back to the water table, could be studied. Pumping and effluent data are being utilized in conjunction with chemical measurements made in groundwater and a series of numerical models to better understand the movement of radionuclides in the system, both between the test and the well, and between the ditch and the water table. The release of radionuclides away from a testing area will be controlled by local groundwater flow rates, by their dissolution from solidified melt glass produced by the test, and by chemical sorption processes that retard their migration rates in chemically reactive geologic media. Only the more mobile and less reactive radionuclides (e.g.. tritium, 14 C, 36 Cl, 85 Kr, and 129 I) were measured in the well effluent. The movement of these radionuclides through the unsaturated media beneath the ditch will be affected additionally by the capillary nature of moisture movement under unsaturated conditions and by their interaction with and potential mass exchange with the gas (air) phase. Results of numerical simulations

  4. Investigating the role of transportation models in epidemiologic studies of traffic related air pollution and health effects.

    Science.gov (United States)

    Shekarrizfard, Maryam; Valois, Marie-France; Goldberg, Mark S; Crouse, Dan; Ross, Nancy; Parent, Marie-Elise; Yasmin, Shamsunnahar; Hatzopoulou, Marianne

    2015-07-01

    In two earlier case-control studies conducted in Montreal, nitrogen dioxide (NO2), a marker for traffic-related air pollution was found to be associated with the incidence of postmenopausal breast cancer and prostate cancer. These studies relied on a land use regression model (LUR) for NO2 that is commonly used in epidemiologic studies for deriving estimates of traffic-related air pollution. Here, we investigate the use of a transportation model developed during the summer season to generate a measure of traffic emissions as an alternative to the LUR model. Our traffic model provides estimates of emissions of nitrogen oxides (NOx) at the level of individual roads, as does the LUR model. Our main objective was to compare the distribution of the spatial estimates of NOx computed from our transportation model to the distribution obtained from the LUR model. A secondary objective was to compare estimates of risk using these two exposure estimates. We observed that the correlation (spearman) between our two measures of exposure (NO2 and NOx) ranged from less than 0.3 to more than 0.9 across Montreal neighborhoods. The most important factor affecting the "agreement" between the two measures in a specific area was found to be the length of roads. Areas affected by a high level of traffic-related air pollution had a far better agreement between the two exposure measures. A comparison of odds ratios (ORs) obtained from NO2 and NOx used in two case-control studies of breast and prostate cancer, showed that the differences between the ORs associated with NO2 exposure vs NOx exposure differed by 5.2-8.8%. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Comparison of robustness to outliers between robust poisson models and log-binomial models when estimating relative risks for common binary outcomes: a simulation study.

    Science.gov (United States)

    Chen, Wansu; Shi, Jiaxiao; Qian, Lei; Azen, Stanley P

    2014-06-26

    To estimate relative risks or risk ratios for common binary outcomes, the most popular model-based methods are the robust (also known as modified) Poisson and the log-binomial regression. Of the two methods, it is believed that the log-binomial regression yields more efficient estimators because it is maximum likelihood based, while the robust Poisson model may be less affected by outliers. Evidence to support the robustness of robust Poisson models in comparison with log-binomial models is very limited. In this study a simulation was conducted to evaluate the performance of the two methods in several scenarios where outliers existed. The findings indicate that for data coming from a population where the relationship between the outcome and the covariate was in a simple form (e.g. log-linear), the two models yielded comparable biases and mean square errors. However, if the true relationship contained a higher order term, the robust Poisson models consistently outperformed the log-binomial models even when the level of contamination is low. The robust Poisson models are more robust (or less sensitive) to outliers compared to the log-binomial models when estimating relative risks or risk ratios for common binary outcomes. Users should be aware of the limitations when choosing appropriate models to estimate relative risks or risk ratios.

  6. How Studies of the Serotonin System in Macaque Models of Menopause Relate to Alzheimer’s

    OpenAIRE

    Bethea, Cynthia L; Reddy, Arubala P; Christian, Fernanda Lima

    2017-01-01

    Serotonin plays a key role in mood or affect, and dysfunction of the serotonin system has been linked to depression in humans and animal models. Depression appears prior to or coincident with overt symptoms of Alzheimer’s (ALZ) disease in about 50% of patients, and some experts consider it a risk factor for the development of ALZ. In addition, ALZ is more prevalent in women, who also show increased incidence of depression. Indeed, it has been proposed that mechanisms underlying depression ove...

  7. Study on the Development of Quality Measurements Models for Steering Business Services in Relation to Customer Satisfaction

    Directory of Open Access Journals (Sweden)

    Katrin Marquardt

    2017-02-01

    Full Text Available The growing competition in the market, higher customer demands and globalisation forces the business service providers to improve their services much faster. Nowadays, it is not enough to provide good quality it is more important to delight the customers and to deliver more than they expect. Likewise, renowned research companies predicted that customer satisfaction will become the competitive differentiator within the next years. Thus, the main reasons of the present study are at first, establishing a common understanding on the term “quality” and presenting the relationship between customer satisfaction and service quality. Secondly, the study summarizes the identified factors, which mostly influence the customer satisfaction, as well as the common methods used to measure service quality in relation to these factors. Thirdly, the authors introduce and explain the newly developed six step model for establishing an effective measurement method for service quality and the proposed three level service quality model with the related measurements and outcomes. Both models will assist business service providers to protect and improve their service quality and with that their customer satisfaction. The methodology used for this research is a systematic literature review focused on subjects of quality, customer satisfaction and best-practice metrics for service quality. In addition, surveys and studies from well-known research companies were evaluated. The outcome of the study is always focused on the business service area.

  8. Dyadic conflict, drinking to cope, and alcohol-related problems: A psychometric study and longitudinal actor-partner interdependence model.

    Science.gov (United States)

    Lambe, Laura; Mackinnon, Sean P; Stewart, Sherry H

    2015-10-01

    The motivational model of alcohol use posits that individuals may consume alcohol to cope with negative affect. Conflict with others is a strong predictor of coping motives, which in turn predict alcohol-related problems. Two studies examined links between conflict, coping motives, and alcohol-related problems in emerging adult romantic dyads. It was hypothesized that the association between conflict and alcohol-related problems would be mediated by coping-depression and coping-anxiety motives. It was also hypothesized that this would be true for actor (i.e., how individual factors influence individual behaviors) and partner effects (i.e., how partner factors influence individual behaviors) and at the between- (i.e., does not vary over the study period) and within-subjects (i.e., varies over the study period) levels. Both studies examined participants currently in a romantic relationship who consumed ≥12 alcoholic drinks in the past year. Study 1 was cross-sectional using university students (N = 130 students; 86.9% female; M = 21.02 years old, SD = 3.43). Study 2 used a 4-wave, 4-week longitudinal design with romantic dyads (N = 100 dyads; 89% heterosexual; M = 22.13 years old, SD = 5.67). In Study 2, coping-depression motives emerged as the strongest mediator of the conflict-alcohol-related problems association, and findings held for actor effects but not partner effects. Supplemental analyses revealed that this mediational pathway only held among women. Within any given week, alcohol-related problems changed systematically in the same direction between romantic partners. Interventions may wish to target coping-depression drinking motives within couples in response to conflict to reduce alcohol-related problems. (c) 2015 APA, all rights reserved).

  9. Case studies of community relations on DOE's Formerly Utilized Sites Remedial Action Program as models for Superfund sites

    International Nuclear Information System (INIS)

    Plant, S.W.; Adler, D.G.

    1995-01-01

    Ever since the US Department of Energy (DOE) created its Formerly Utilized Sites Remedial Action Program (FUSRAP) in 1974, there has been a community relations program. The community relations effort has grown as FUSRAP has grown. With 20 of 46 sites now cleaned up, considerable experience in working with FUSRAP stakeholders has been gained. Why not share that experience with others who labor on the Superfund sites? Many similarities exist between the Superfund sites and FUSRAP. FUSRAP is a large, multiple-site environmental restoration program. The challenges range from small sites requiring remedial actions measurable in weeks to major sites requiring the full remedial investigation/feasibility study process. The numerous Superfund sites throughout the United States offer the same diversity, both geographically and technically. But before DOE offers FUSRAP's community relations experience as a model, it needs to make clear that this will be a realistic model. As experiences are shared, DOE will certainly speak of the efforts that achieved its goals. But many of the problems that DOE encountered along the way will also be related. FUSRAP relies on a variety of one- and two-way communication techniques for involving stakeholders in the DOE decision-making process. Some of the techniques and experiences from the case studies are presented

  10. Anterior cingulate cortico-hippocampal dysconnectivity in unaffected relatives of schizophrenia patients: a stochastic dynamic causal modeling study

    Directory of Open Access Journals (Sweden)

    Yi-Bin Xi

    2016-07-01

    Full Text Available Familial risk plays a significant role in the etiology of schizophrenia (SZ. Many studies using neuroimaging have demonstrated structural and functional alterations in relatives of SZ patients, with significant results found in diverse brain regions involving the anterior cingulate cortex (ACC, caudate, dorsolateral prefrontal cortex (DLPFC, and hippocampus. This study investigated whether unaffected relatives of first episode SZ differ from healthy controls (HCs in effective connectivity measures among these regions. Forty-six unaffected first-degree relatives of first episode SZ patients — according to the DSM-IV — were studied. Fifty HCs were included for comparison. All subjects underwent resting state functional magnetic resonance imaging (fMRI. We used stochastic dynamic causal modeling (sDCM to estimate the directed connections between the left ACC, right ACC, left caudate, right caudate, left DLPFC, left hippocampus, and right hippocampus. We used Bayesian parameter averaging (BPA to characterize the differences. The BPA results showed hyperconnectivity from the left ACC to right hippocampus and hypoconnectivity from the right ACC to right hippocampus in SZ relatives compared to HCs. The pattern of anterior cingulate cortico-hippocampal connectivity in SZ relatives may be a familial feature of SZ risk, appearing to reflect familial susceptibility for SZ.

  11. Expression study of GLUT4 translocation-related genes in a porcine pre-diabetic model

    DEFF Research Database (Denmark)

    Kristensen, Thea; Fredholm, Merete; Cirera Salicio, Susanna

    2015-01-01

    Obesity is a world-wide exponentially growing health problem that increases the risk of co-morbidities including metabolic syndrome, pre-diabetes, Type 2 Diabetes Mellitus (T2DM), and cancer. These co-morbidities are all complex conditions constituting a big challenge when searching...... this phenotype might provide knowledge on relevant genes implicated in molecular mechanisms underlying pre-diabetes, and contributing to the development of T2DM. In the present study, two groups of pigs with high (HGG, N = 6) and low (NGG, N = 6) fasting plasma glucose level respectively were selected from...

  12. Study on uncertainty evaluation methodology related to hydrological parameter of regional groundwater flow analysis model

    International Nuclear Information System (INIS)

    Sakai, Ryutaro; Munakata, Masahiro; Ohoka, Masao; Kameya, Hiroshi

    2009-11-01

    In the safety assessment for a geological disposal of radioactive waste, it is important to develop a methodology for long-term estimation of regional groundwater flow from data acquisition to numerical analyses. In the uncertainties associated with estimation of regional groundwater flow, there are the one that concerns parameters and the one that concerns the hydrologeological evolution. The uncertainties of parameters include measurement errors and their heterogeneity. The authors discussed the uncertainties of hydraulic conductivity as a significant parameter for regional groundwater flow analysis. This study suggests that hydraulic conductivities of rock mass are controlled by rock characteristics such as fractures, porosity and test conditions such as hydraulic gradient, water quality, water temperature and that there exists variations more than ten times in hydraulic conductivity by difference due to test conditions such as hydraulic gradient or due to rock type variations such as rock fractures, porosity. In addition this study demonstrated that confining pressure change caused by uplift and subsidence and change of hydraulic gradient under the long-term evolution of hydrogeological environment could possibly produce variations more than ten times of magnitude in hydraulic conductivity. It was also shown that the effect of water quality change on hydraulic conductivity was not negligible and that the replacement of fresh water and saline water caused by sea level change could induce 0.6 times in current hydraulic conductivities in case of Horonobe site. (author)

  13. Effects of Health-Related Food Taxes and Subsidies on Mortality from Diet-Related Disease in New Zealand: An Econometric-Epidemiologic Modelling Study.

    Science.gov (United States)

    Ni Mhurchu, Cliona; Eyles, Helen; Genc, Murat; Scarborough, Peter; Rayner, Mike; Mizdrak, Anja; Nnoaham, Kelechi; Blakely, Tony

    2015-01-01

    Health-related food taxes and subsidies may promote healthier diets and reduce mortality. Our aim was to estimate the effects of health-related food taxes and subsidies on deaths prevented or postponed (DPP) in New Zealand. A macrosimulation model based on household expenditure data, demand elasticities and population impact fractions for 18 diet-related diseases was used to estimate effects of five tax and subsidy regimens. We used price elasticity values for 24 major commonly consumed food groups in New Zealand, and food expenditure data from national Household Economic Surveys. Changes in mortality from cardiovascular disease, cancer, diabetes and other diet-related diseases were estimated. A 20% subsidy on fruit and vegetables would result in 560 (95% uncertainty interval, 400 to 700) DPP each year (1.9% annual all-cause mortality). A 20% tax on major dietary sources of saturated fat would result in 1,500 (950 to 2,100) DPP (5.0%), and a 20% tax on major dietary sources of sodium would result in 2,000 (1300 to 2,700) DPP (6.8%). Combining taxes on saturated fat and sodium with a fruit and vegetable subsidy would result in 2,400 (1,800 to 3,000) DPP (8.1% mortality annually). A tax on major dietary sources of greenhouse gas emissions would generate 1,200 (750 to 1,700) DPP annually (4.0%). Effects were similar or greater for Maori and low-income households in relative terms. Health-related food taxes and subsidies could improve diets and reduce mortality from diet-related disease in New Zealand. Our study adds to the growing evidence base suggesting food pricing policies should improve population health and reduce inequalities, but there is still much work to be done to improve estimation of health impacts.

  14. Effects of Health-Related Food Taxes and Subsidies on Mortality from Diet-Related Disease in New Zealand: An Econometric-Epidemiologic Modelling Study

    Science.gov (United States)

    Ni Mhurchu, Cliona; Eyles, Helen; Genc, Murat; Scarborough, Peter; Rayner, Mike; Mizdrak, Anja; Nnoaham, Kelechi; Blakely, Tony

    2015-01-01

    Background Health-related food taxes and subsidies may promote healthier diets and reduce mortality. Our aim was to estimate the effects of health-related food taxes and subsidies on deaths prevented or postponed (DPP) in New Zealand. Methods A macrosimulation model based on household expenditure data, demand elasticities and population impact fractions for 18 diet-related diseases was used to estimate effects of five tax and subsidy regimens. We used price elasticity values for 24 major commonly consumed food groups in New Zealand, and food expenditure data from national Household Economic Surveys. Changes in mortality from cardiovascular disease, cancer, diabetes and other diet-related diseases were estimated. Findings A 20% subsidy on fruit and vegetables would result in 560 (95% uncertainty interval, 400 to 700) DPP each year (1.9% annual all-cause mortality). A 20% tax on major dietary sources of saturated fat would result in 1,500 (950 to 2,100) DPP (5.0%), and a 20% tax on major dietary sources of sodium would result in 2,000 (1300 to 2,700) DPP (6.8%). Combining taxes on saturated fat and sodium with a fruit and vegetable subsidy would result in 2,400 (1,800 to 3,000) DPP (8.1% mortality annually). A tax on major dietary sources of greenhouse gas emissions would generate 1,200 (750 to 1,700) DPP annually (4.0%). Effects were similar or greater for Maori and low-income households in relative terms. Conclusions Health-related food taxes and subsidies could improve diets and reduce mortality from diet-related disease in New Zealand. Our study adds to the growing evidence base suggesting food pricing policies should improve population health and reduce inequalities, but there is still much work to be done to improve estimation of health impacts. PMID:26154289

  15. Studying psychosocial adaptation to end-stage renal disease: the proximal-distal model of health-related outcomes as a base model.

    Science.gov (United States)

    Chan, Ramony; Brooks, Robert; Erlich, Jonathan; Gallagher, Martin; Snelling, Paul; Chow, Josephine; Suranyi, Michael

    2011-05-01

    Studying psychosocial adaptation in end-stage renal disease (ESRD) is increasingly important, as it may explain the variability in health outcomes unaccounted for by clinical factors. The Brenner et al. proximal-distal model of health-related outcomes provides a theoretical foundation for understanding psychosocial adaptation and integrating health outcomes, clinical, and psychosocial factors (Brenner MH, Curbow B, Legro MW. The proximal-distal continuum of multiple health outcome measures: the case of cataract surgery. Med Care. 1995;33(4 Suppl):AS236-44). This study aims to empirically validate the proximal-distal model in the dialysis population and examine the impact of psychosocial factors on the model. A cross-sectional observational study was conducted with a sample of long-term dialysis patients (n=201). Eleven factors: quality of life (QoL), depression, positive affect, comorbidity, symptoms, physical functioning, disease accommodation, loss, self-efficacy, illness acceptance, and social support were measured by standardized psychometric scales. A three-month average of hemoglobin was used. Latent composite structural equation modeling was used to examine the models. The proximal-distal model with slight modification was supported by fit statistics [χ(2)=16.04, df=13, P=.25, root mean square error of approximation (RMSEA)=0.024], indicating that the impact of clinical factors on QoL is mediated through a range of functional and psychological factors, except for hemoglobin which impacts directly on QoL. The model with additional psychosocial factors was also supported by fit statistics (χ(2)=43.59, df=41, P=.36, RMSEA=0.018). These additional factors mainly impact on symptom status, psychological states, and QoL components of the model. The present study supported the proximal-distal model in the dialysis population and demonstrated the considerable impact of psychosocial factors on the model. The proximal-distal model plus psychosocial factors as a

  16. Development of relative risk model for regional groundwater risk assessment: a case study in the lower Liaohe River Plain, China.

    Science.gov (United States)

    Li, Xianbo; Zuo, Rui; Teng, Yanguo; Wang, Jinsheng; Wang, Bin

    2015-01-01

    Increasing pressure on water supply worldwide, especially in arid areas, has resulted in groundwater overexploitation and contamination, and subsequent deterioration of the groundwater quality and threats to public health. Environmental risk assessment of regional groundwater is an important tool for groundwater protection. This study presents a new approach for assessing the environmental risk assessment of regional groundwater. It was carried out with a relative risk model (RRM) coupled with a series of indices, such as a groundwater vulnerability index, which includes receptor analysis, risk source analysis, risk exposure and hazard analysis, risk characterization, and management of groundwater. The risk map is a product of the probability of environmental contamination and impact. The reliability of the RRM was verified using Monte Carlo analysis. This approach was applied to the lower Liaohe River Plain (LLRP), northeastern China, which covers 23604 km2. A spatial analysis tool within GIS which was used to interpolate and manipulate the data to develop environmental risk maps of regional groundwater, divided the level of risk from high to low into five ranks (V, IV, III, II, I). The results indicate that areas of relative risk rank (RRR) V cover 2324 km2, covering 9.8% of the area; RRR IV covers 3986 km2, accounting for 16.9% of the area. It is a new and appropriate method for regional groundwater resource management and land use planning, and is a rapid and effective tool for improving strategic decision making to protect groundwater and reduce environmental risk.

  17. A vegetation-focused soil-plant-atmospheric continuum model to study hydrodynamic soil-plant water relations

    Science.gov (United States)

    Deng, Zijuan; Guan, Huade; Hutson, John; Forster, Michael A.; Wang, Yunquan; Simmons, Craig T.

    2017-06-01

    A novel simple soil-plant-atmospheric continuum model that emphasizes the vegetation's role in controlling water transfer (v-SPAC) has been developed in this study. The v-SPAC model aims to incorporate both plant and soil hydrological measurements into plant water transfer modeling. The model is different from previous SPAC models in which v-SPAC uses (1) a dynamic plant resistance system in the form of a vulnerability curve that can be easily obtained from sap flow and stem xylem water potential time series and (2) a plant capacitance parameter to buffer the effects of transpiration on root water uptake. The unique representation of root resistance and capacitance allows the model to embrace SPAC hydraulic pathway from bulk soil, to soil-root interface, to root xylem, and finally to stem xylem where the xylem water potential is measured. The v-SPAC model was tested on a native tree species in Australia, Eucalyptus crenulata saplings, with controlled drought treatment. To further validate the robustness of the v-SPAC model, it was compared against a soil-focused SPAC model, LEACHM. The v-SPAC model simulation results closely matched the observed sap flow and stem water potential time series, as well as the soil moisture variation of the experiment. The v-SPAC model was found to be more accurate in predicting measured data than the LEACHM model, underscoring the importance of incorporating root resistance into SPAC models and the benefit of integrating plant measurements to constrain SPAC modeling.

  18. Studies Relating to EVA

    Science.gov (United States)

    1997-01-01

    In this session, Session JA1, the discussion focuses on the following topics: The Staged Decompression to the Hypobaric Atmosphere as a Prophylactic Measure Against Decompression Sickness During Repetitive EVA; A New Preoxygenation Procedure for Extravehicular Activity (EVA); Metabolic Assessments During Extra-Vehicular Activity; Evaluation of Safety of Hypobaric Decompressions and EVA From Positions of Probabilistic Theory; Fatty Acid Composition of Plasma Lipids and Erythrocyte Membranes During Simulation of Extravehicular Activity; Biomedical Studies Relating to Decompression Stress with Simulated EVA, Overview; The Joint Angle and Muscle Signature (JAMS) System - Current Uses and Future Applications; and Experimental Investigation of Cooperative Human-Robotic Roles in an EVA Work Site.

  19. Japanese medaka: a non-mammalian vertebrate model for studying sex and age-related bone metabolism in vivo.

    Directory of Open Access Journals (Sweden)

    Admane H Shanthanagouda

    Full Text Available BACKGROUND: In human, a reduction in estrogen has been proposed as one of the key contributing factors for postmenopausal osteoporosis. Rodents are conventional models for studying postmenopausal osteoporosis, but the major limitation is that ovariectomy is needed to mimic the estrogen decline after menopause. Interestingly, in medaka fish (Oryzias latipes, we observed a natural drop in plasma estrogen profile in females during aging and abnormal spinal curvature was apparent in old fish, which are similar to postmenopausal women. It is hypothesized that estrogen associated disorders in bone metabolism might be predicted and prevented by estrogen supplement in aging O. latipes, which could be corresponding to postmenopausal osteoporosis in women. PRINCIPAL FINDINGS: In O. latipes, plasma estrogen was peaked at 8 months old and significantly declined after 10, 11 and 22 months in females. Spinal bone mineral density (BMD and micro-architecture by microCT measurement progressively decreased and deteriorated from 8 to 10, 12 and 14 months old, which was more apparent in females than the male counterparts. After 10 months old, O. latipes were supplemented with 17α-ethinylestradiol (EE2, a potent estrogen mimic at 6 and 60 ng/mg fish weight/day for 4 weeks, both reduction in spinal BMD and deterioration in bone micro-architecture were significantly prevented. The estrogenic effect of EE2 in O. latipes was confirmed by significant up-regulation of four key estrogen responsive genes in the liver. In general, bone histomorphometric analyses indicated significantly lowered osteoblasts and osteoclasts numbers and surfaces on vertebrae of EE2-fed medaka. SIGNIFICANCE: We demonstrate osteoporosis development associated with natural drop in estrogen level during aging in female medaka, which could be attenuated by estrogen treatment. This small size fish is a unique alternative non-mammalian vertebrate model for studying estrogen-related molecular

  20. Japanese Medaka: A Non-Mammalian Vertebrate Model for Studying Sex and Age-Related Bone Metabolism In Vivo

    Science.gov (United States)

    Ye, Rui R.; Chao, Liang; Chiang, Michael W. L.; Singaram, Gopalakrishnan; Cheung, Napo K. M.; Zhang, Ge; Au, Doris W. T.

    2014-01-01

    Background In human, a reduction in estrogen has been proposed as one of the key contributing factors for postmenopausal osteoporosis. Rodents are conventional models for studying postmenopausal osteoporosis, but the major limitation is that ovariectomy is needed to mimic the estrogen decline after menopause. Interestingly, in medaka fish (Oryzias latipes), we observed a natural drop in plasma estrogen profile in females during aging and abnormal spinal curvature was apparent in old fish, which are similar to postmenopausal women. It is hypothesized that estrogen associated disorders in bone metabolism might be predicted and prevented by estrogen supplement in aging O. latipes, which could be corresponding to postmenopausal osteoporosis in women. Principal findings In O. latipes, plasma estrogen was peaked at 8 months old and significantly declined after 10, 11 and 22 months in females. Spinal bone mineral density (BMD) and micro-architecture by microCT measurement progressively decreased and deteriorated from 8 to 10, 12 and 14 months old, which was more apparent in females than the male counterparts. After 10 months old, O. latipes were supplemented with 17α-ethinylestradiol (EE2, a potent estrogen mimic) at 6 and 60 ng/mg fish weight/day for 4 weeks, both reduction in spinal BMD and deterioration in bone micro-architecture were significantly prevented. The estrogenic effect of EE2 in O. latipes was confirmed by significant up-regulation of four key estrogen responsive genes in the liver. In general, bone histomorphometric analyses indicated significantly lowered osteoblasts and osteoclasts numbers and surfaces on vertebrae of EE2-fed medaka. Significance We demonstrate osteoporosis development associated with natural drop in estrogen level during aging in female medaka, which could be attenuated by estrogen treatment. This small size fish is a unique alternative non-mammalian vertebrate model for studying estrogen-related molecular regulation in postmenopausal

  1. Integrating autism-related symptoms into the dimensional internalizing and externalizing model of psychopathology. The TRAILS Study.

    Science.gov (United States)

    Noordhof, Arjen; Krueger, Robert F; Ormel, Johan; Oldehinkel, Albertine J; Hartman, Catharina A

    2015-04-01

    Problems associated with Autism Spectrum Disorder (ASD) occur frequently in the general population and often co-occur with problems in other domains of psychopathology. In the research presented here these co-occurrence patterns were investigated by integrating a dimensional approach to ASDs into the more general dimensional framework of internalizing and externalizing psychopathology. Factor Analysis was used to develop hierarchical and bi-factor models covering multiple domains of psychopathology in three measurement waves of a longitudinal general population sample (N = 2,230, ages 10-17, 50.8% female). In all adequately fitting models, autism related problems were part of a specific domain of psychopathology that could be distinguished from the internalizing and externalizing domains. Optimal model fit was found for a bi-factor model with one non-specific factor and four specific factors related to internalizing, externalizing, autism spectrum problems and problems related to attention and orientation. Autism-related problems constitute a specific domain of psychopathology that can be distinguished from the internalizing and externalizing domains. In addition, the co-occurrence patterns in the data indicate the presence of a strong general factor.

  2. Cosmological models in general relativity

    Indian Academy of Sciences (India)

    Cosmological models in general relativity. B B PAUL. Department of Physics, Nowgong College, Nagaon, Assam, India. MS received 4 October 2002; revised 6 March 2003; accepted 21 May 2003. Abstract. LRS Bianchi type-I space-time filled with perfect fluid is considered here with deceler- ation parameter as variable.

  3. Adverse events related to gastrointestinal endoscopic procedures in pediatric patients under anesthesia care and a predictive risk model (AEGEP Study).

    Science.gov (United States)

    Ariza, F; Montilla-Coral, D; Franco, O; González, L F; Lozano, L C; Torres, A M; Jordán, J; Blanco, L F; Suárez, L; Cruz, G; Cepeda, M

    2014-01-01

    Multiple studies have analyzed perioperative factors related to adverse events (AEs) in children who require gastrointestinal endoscopic procedures (GEP) in settings where deep sedation is the preferred anesthetic technique over general anesthesia (GA) but not for the opposite case. We reviewed our anesthesia institutional database, seeking children less than 12 years who underwent GEP over a 5-year period. A logistic regression was used to determine significant associations between preoperative conditions, characteristics of the procedure, airway management, anesthetic approaches and the presence of serious and non-serious AEs. GA was preferred over deep sedation [77.8% vs. 22.2% in 2178 GEP under anesthesia care (n=1742)]. We found 96 AEs reported in 77 patients, including hypoxemia (1.82%), bronchospasm (1.14%) and laryngospasm (0.91%) as the most frequent. There were 2 cases of severe bradycardia related to laryngospasm/hypoxemia and a case of aspiration resulting in unplanned hospitalization, but there were no cases of intra- or postoperative deaths. Final predictive model for perioperative AEs included age <1 year, upper respiratory tract infections (URTI) <1 week prior to the procedure and low weight for the age (LWA) as independent risk factors and ventilation by facial mask as a protector against these events (p<0.05). AEs are infrequent and severe ones are remote in a setting where AG is preferred over deep sedation. Ventilatory AEs are the most frequent and depend on biometrical and comorbid conditions more than anesthetic drugs chosen. Age <1 year, history of URTI in the week prior to the procedure and LWA work as independent risk factors for AEs in these patients. Copyright © 2013 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España. All rights reserved.

  4. A shared frailty model for case-cohort samples: parent and offspring relations in an adoption study

    DEFF Research Database (Denmark)

    Petersen, Liselotte; Sørensen, Thorkild I A; Andersen, Per Kragh

    2010-01-01

    probability weighting to account for the sampling in a conditional, shared frailty Poisson model and to use the robust variance estimator proposed by Moger et al. (Statist. Med. 2008; 27:1062-1074).To explore the performance of the estimation procedure, a simulation study was conducted. We studied situations...... of their biological and adoptive parents were collected with the purpose of studying the association of survival between the adoptee and his/her biological or adoptive parents. Motivated by this study, we explored how to make inference in a shared frailty model for case-cohort data. Our approach was to use inverse...

  5. Epistemology and Rosen's Modeling Relation

    International Nuclear Information System (INIS)

    Dress, W.B.

    1999-01-01

    Rosen's modeling relation is embedded in Popper's three worlds to provide an heuristic tool for model building and a guide for thinking about complex systems. The utility of this construct is demonstrated by suggesting a solution to the problem of pseudo science and a resolution of the famous Bohr-Einstein debates. A theory of bizarre systems is presented by an analogy with entangled particles of quantum mechanics. This theory underscores the poverty of present-day computational systems (e.g., computers) for creating complex and bizarre entities by distinguishing between mechanism and organism

  6. Drosophila, a genetic model system to study cocaine-related behaviors: A review with focus on LIM-only proteins

    OpenAIRE

    Heberlein, Ulrike; Tsai, Linus T.–Y.; Kapfhamer, David; Lasek, Amy W.

    2008-01-01

    In the last decade, the fruit fly Drosophila melanogaster, highly accessible to genetic, behavioral and molecular analyses, has been introduced as a novel model organism to help decipher the complex genetic, neurochemical, and neuroanatomical underpinnings of behaviors induced by drugs of abuse. Here we review these data, focusing specifically on cocaine-related behaviors. Several of cocaine's most characteristic properties have been recapitulated in Drosophila. First, cocaine induces motor b...

  7. Persuasion, Politeness and Relational Models

    Directory of Open Access Journals (Sweden)

    Jerzy Świątek

    2017-06-01

    Full Text Available Politeness Theory, just like Grice’s Cooperative Principle, points out that pragmatic analysis of language behaviour has to be grounded in extra-linguistic facts of social (or even biological nature. Additionally, despite the slightly misleading label, Politeness Theory provides a sound methodology to explain some persuasive as well as politeness phenomena. In the same vein, the so called Relational Model Theory provides another theoretical framework for the explanation of persuasive phenomena and persuasive language. Both Relational Model Theory and Politeness Theory show that persuasion is also to be understood as a rational response to not-so-rational social and biological needs. In the article an attempt is made to compare the two theories focusing on their explanatory power in reference to language choices aiming at enhancing the persuasive potential of a language message.

  8. The SF-8 Spanish Version for Health-Related Quality of Life Assessment: Psychometric Study with IRT and CFA Models.

    Science.gov (United States)

    Tomás, José M; Galiana, Laura; Fernández, Irene

    2018-03-22

    The aim of current research is to analyze the psychometric properties of the Spanish version of the SF-8, overcoming previous shortcomings. A double line of analyses was used: competitive structural equations models to establish factorial validity, and Item Response theory to analyze item psychometric characteristics and information. 593 people aged 60 years or older, attending long life learning programs at the University were surveyed. Their age ranged from 60 to 92 years old. 67.6% were women. The survey included scales on personality dimensions, attitudes, perceptions, and behaviors related to aging. Competitive confirmatory models pointed out two-factors (physical and mental health) as the best representation of the data: χ2(13) = 72.37 (p < .01); CFI = .99; TLI = .98; RMSEA = .08 (.06, .10). Item 5 was removed because of unreliability and cross-loading. Graded response models showed appropriate fit for two-parameter logistic model both the physical and the mental dimensions. Item Information Curves and Test Information Functions pointed out that the SF-8 was more informative for low levels of health. The Spanish SF-8 has adequate psychometric properties, being better represented by two dimensions, once Item 5 is removed. Gathering evidence on patient-reported outcome measures is of crucial importance, as this type of measurement instruments are increasingly used in clinical arena.

  9. A psycho-economic model of ecstasy consumption and related consequences: a multi-site study with community samples.

    Science.gov (United States)

    Abdallah, Arbi Ben; Scheier, Lawrence M; Inciardi, James A; Copeland, Jan; Cottler, Linda B

    2007-01-01

    Becker and Murphy's (1988) theory of rational behavior suggests that economic factors play an influential role in the decision leading to drug consumption and possibly dependence. Psychological models, on the other hand, emphasize internal regulatory cues that motivate drug use and play a contributory role in dependence. Until now, the confluence of both economic and psychological models has not been tested empirically. The present study used latent-variable structural equation modeling (SEM) to examine the influence of both economic (social anomie, unit price, and time spent acquiring drugs) and psychological risk factors (motivation, depression, and sexual risk behaviors) on self-reported ecstasy use. Data were obtained from 612 recreational ecstasy users in the United States and Australia participating in a NIDA-funded epidemiological study examining trends in ecstasy use. The sample was mainly white (61%), male (58%), and young (mean age = 23 yrs [5.25]). All of the hypothesized latent constructs were statistically reliable and correlated in the expected direction. A saturated SEM indicated that monetary and opportunity cost, but not income, significantly predicted ecstasy use. Among the psychological measures, motivational cues were the strongest predictor of both use and dependence. Inclusion of gender, age, race, education, and site variables did not appreciably alter the final model parameters. The implications of incorporating the role of economic factors in shaping a more refined understanding of addiction are discussed. Suggestions for future research and study limitations are also noted.

  10. Analysis of the Relation between Academic Procrastination, Academic Rational/Irrational Beliefs, Time Preferences to Study for Exams, and Academic Achievement: A Structural Model

    Science.gov (United States)

    Balkis, Murat; Duru, Erdinc; Bulus, Mustafa

    2013-01-01

    The purpose of this study was to investigate the relations between academic rational/irrational beliefs, academic procrastination, and time preferences to study for exams and academic achievement by using the structural equation model. The sample consisted of 281 undergraduate students who filled in questionnaires at the 7-week-long summer course.…

  11. Management of resources at major incidents and disasters in relation to patient outcome: a pilot study of an educational model.

    Science.gov (United States)

    Nilsson, Heléne; Rüter, Anders

    2008-06-01

    Organizations involved in disaster response often have a defined operative level of management (command and control) that can take the overall decisions regarding the mobilization and distribution of resources and distribution of casualties. This level of management can be referred to as strategic management. The aim of this pilot study was to show the possibility, in simulation exercises, to relate decisions made regarding resources to patient outcome. The simulation system used measures to determine if lifesaving interventions are performed in time or not in relation to patient outcome. Evaluation was made with sets of performance indicators as templates and all management groups were evaluated not only as to how the decisions were made (management skills), but also how staff work was performed (staff procedure skills). Owing to inadequate response and insufficient distribution of patients to hospitals, 11 'patients' died in the simulated incident, a fire at a football stand with subsequent collapse. The strategic level of management received 16 points out of a possible 22 according to a predesigned template of performance indicators. The pilot study demonstrated the possibility to, in simulation exercises, relate decisions made regarding resources to patient outcome. This training technique could possibly lead to increased knowledge in what decisions are crucial to make in an early phase to minimize mortality and morbidity.

  12. Relating Derived Relations as a Model of Analogical Reasoning: Reaction Times and Event-Related Potentials

    Science.gov (United States)

    Barnes-Holmes, Dermot; Regan, Donal; Barnes-Holmes, Yvonne; Commins, Sean; Walsh, Derek; Stewart, Ian; Smeets, Paul M.; Whelan, Robert; Dymond, Simon

    2005-01-01

    The current study aimed to test a Relational Frame Theory (RFT) model of analogical reasoning based on the relating of derived same and derived difference relations. Experiment 1 recorded reaction time measures of similar-similar (e.g., "apple is to orange as dog is to cat") versus different-different (e.g., "he is to his brother as…

  13. Survival probability of Baltic larval cod in relation to spatial overlap patterns with their prey obtained from drift model studies

    DEFF Research Database (Denmark)

    Hinrichsen, H.H.; Schmidt, J.O.; Petereit, C.

    2005-01-01

    Temporal mismatch between the occurrence of larvae and their prey potentially affects the spatial overlap and thus the contact rates between predator and prey. This might have important consequences for growth and survival. We performed a case study investigating the influence of circulation......-prey overlap, dependent on the hatching time of cod larvae. By performing model runs for the years 1979-1998 investigated the intra- and interannual variability of potential spatial overlap between predator and prey. Assuming uniform prey distributions, we generally found the overlap to have decreased since...

  14. Establishing quantitative relations between mammalian communities, climate regimes, and vegetation density - A diversity-based reference model and case study

    Science.gov (United States)

    Hertler, Christine; Wolf, Dominik; Bruch, Angela; Märker, Michael

    2013-04-01

    A considerable diversity of hominin taxa is described from the Pleistocene of sub-Saharan Africa. Inner-African range expansions of these taxa are primarily addressed by morphological comparisons of the hominin specimens and systematic interpretation of the results. Considering hominin expansion patterns as being at least co-determined by ecology and environment requires an assessment of respective features of paleo-communities as well as features of the environments with which they are associated. Challenges in validation and integration of reconstructions of hominin environments and ecologies can be met with well-organized recent reference models. Modelling the present day situation permits to assess relevant variables and to establish interactions among them on a quantitative basis. In a next step such a model can be applied to classify hominin paleoenvironments, for which not all data sources are available. An example for this approach is introduced here. In order to characterize hominin environments in sub-Saharan Africa, we assessed sets of variables for composition, structure and diversity of the large mammal communities, climate (temperature and precipitation), and vegetation in African national parks. These data are applied to analyse correlations between faunal communities and their environments on a quantitative basis. While information on large mammal communities is frequently available for hominin localities and regional climate features are addressed on the basis of abiotic proxies, information on paleoflora and vegetation is mostly lacking for the Plio-Pleistocene in sub-Saharan Africa. A quantitative reference model therefore offers new options for reconstructions. A recent reference model moreover permits to quantify descriptive terms like 'savanna'. We will introduce a reference model for sub-Saharan Africa and demonstrate its application in the reconstruction of hominin paleoenvironments. The corresponding quantitative characterization of

  15. Local infusion of Staphylococcus aureus into the porcine internal carotid artery as a model of sepsis-related brain abscesses - A pilot study

    DEFF Research Database (Denmark)

    Astrup, Lærke B.; Iburg, Tine M.; Agerholm, Jørgen S.

    2017-01-01

    Brain pathology is an important aspect of human sepsis but is difficult to study in human patients. Th erefore, animal models of sepsis-related brain pathology are needed. As pigs mirror multiple aspects of sepsis-related brain pathology in humans, this makes the pig a potentially suitable model....... Unfortunately, models of sepsis in pigs are difficult to manage due to the accompanying massive systemic inflammatory response. To overcome these difficulties we designed a model in pigs of brain bacteremia established by local brain infusion in order to evaluate if this approach could reduce the systemic...... responses but still reflect the brain pathology of sepsis in humans. As a pilot study to obtain basic knowledge, we evaluated two methods of local infusion: long term infusion (60 minutes) of Staphylococcus aureus suspended in saline and, short-term infusion (10 minutes) of S. aureus embedded in autologous...

  16. The evaluation of the diet/disease relation in the EPIC study: considerations for the calibration and the disease models

    DEFF Research Database (Denmark)

    Ferrari, Pietro; Day, Nicholas E; Boshuizen, Hendriek C

    2008-01-01

    BACKGROUND: International multicentre studies on diet and cancer are relatively new in epidemiological research. They offer a series of challenging methodological issues for the evaluation of the association between dietary exposure and disease outcomes, which can both be quite heterogeneous across...... different geographical regions. This requires considerable work to standardize dietary measurements at the food and the nutrient levels. METHODS: Within the European Prospective Investigation into Cancer and Nutrition (EPIC), a calibration study was set up to express individual dietary intakes according...... fish intake and colorectal cancer incidence. RESULTS: Sex- and country-specific attenuation factors ranged from 0.083 to 0.784, with values overall higher for men compared with women. Hazard ratio estimates of colorectal cancer for a 10 g/day increase in fish intake were 0.97 [95% confidence interval...

  17. Modeling a Longitudinal Relational Research Data Systems

    Science.gov (United States)

    Olsen, Michelle D. Hunt

    2010-01-01

    A study was conducted to propose a research-based model for a longitudinal data research system that addressed recommendations from a synthesis of literature related to: (1) needs reported by the U.S. Department of Education, (2) the twelve mandatory elements that define federally approved state longitudinal data systems (SLDS), (3) the…

  18. Relative Contribution of Greenhouse Gases and Ozone Change to Temperature Trends in the Stratosphere: A Chemistry/Climate Model Study

    Science.gov (United States)

    Stolarski, Richard S.; Douglass, A. R.; Newman, P. A.; Pawson, S.; Schoeberl, M. R.

    2006-01-01

    Long-term changes in greenhouse gases, primarily carbon dioxide, are expected to lead to a warming of the troposphere and a cooling of the stratosphere. We examine the cooling of the stratosphere and compare the contributions greenhouse gases and ozone change for the decades between 1980 and 2000. We use 150 years of simulation done with our coupled chemistry/climate model (GEOS 4 GCM with GSFC CTM chemistry) to calculate temperatures and constituents fiom,1950 through 2100. The contributions of greenhouse gases and ozone to temperature change are separated by a time-series analysis using a linear trend term throughout the period to represent the effects of greenhouse gases and an equivalent effective stratospheric chlorine (EESC) term to represent the effects of ozone change. The temperature changes over the 150 years of the simulation are dominated by the changes in greenhouse gases. Over the relatively short period (approx. 20 years) of ozone decline between 1980 and 2000 changes in ozone are competitive with changes in greenhouse gases. The changes in temperature induced by the ozone change are comparable to, but smaller than, those of greenhouse gases in the upper stratosphere (1-3 hPa) at mid latitudes. The ozone term dominates the temperature change near both poles with a negative temperature change below about 3-5 hPa and a positive change above. At mid latitudes in the upper stratosphere and mesosphere (above about 1 hPa) and in the middle stratosphere (3 to 70 ma), the greenhouse has term dominates. From about 70 hPa down to the tropopause at mid latitudes, cooling due to ozone changes is the largest influence on temperature. Over the 150 years of the simulation, the change in greenhouse gases is the most important contributor to temperature change. Ozone caused a perturbation that is expected to reverse over the coming decades. We show a model simulation of the expected temperature change over the next two decades (2006-2026). The simulation shows a

  19. Mechanical Models of Fault-Related Folding

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, A. M.

    2003-01-09

    The subject of the proposed research is fault-related folding and ground deformation. The results are relevant to oil-producing structures throughout the world, to understanding of damage that has been observed along and near earthquake ruptures, and to earthquake-producing structures in California and other tectonically-active areas. The objectives of the proposed research were to provide both a unified, mechanical infrastructure for studies of fault-related foldings and to present the results in computer programs that have graphical users interfaces (GUIs) so that structural geologists and geophysicists can model a wide variety of fault-related folds (FaRFs).

  20. Virtual Screening of M3 Protein Antagonists for Finding a Model to Study the Gammaherpesvirus Damaged Immune System and Chemokine Related Diseases

    Directory of Open Access Journals (Sweden)

    Ibrahim Torktaz

    2013-12-01

    Full Text Available Introduction: M3 protein is a chemokine decoy receptor involved in pathogenesis of persistent infection with gammaherpesvirus and complications related to the latency of this pathogen. We proposed that antagonists of the M3 would provide a unique opportunity for studying new therapeutic strategies in disordered immune system, immune-deficient states and role of chemokines in pathogenesis development. Methods: Comparative modeling and fold recognition algorithms have been used for prediction of M3 protein 3-D model. Evaluation of the models using Q-mean and ProSA-web score, has led to choosing predicted model by fold recognition algorithm as the best model which was minimized regarding energy level using Molegro Virtual Docker 2011.4.3.0 (MVD software. Pockets and active sites of model were recognized using MVD cavity detection, and MetaPocket algorithms. Ten thousand compounds accessible on KEGG database were screened; MVD was used for computer simulated docking study; MolDock SE was selected as docking scoring function and final results were evaluated based on MolDock and Re-rank score. Results: Docking data suggested that prilocaine, which is generally applied as a topical anesthetic, binds strongly to 3-D model of M3 protein. Conclusion: This study proposes that prilocaine is a potential inhibitor of M3 protein and possibly has immune enhancing properties.

  1. Emotional and temporal aspects of situation model processing during text comprehension: An event-related fMRI study

    NARCIS (Netherlands)

    Ferstl, E.C.; Rinck, M.; Cramon, D.Y. von

    2005-01-01

    Language comprehension in everyday life requires the continuous integration of prior discourse context and general world knowledge with the current utterance or sentence. In the neurolinguistic literature, these so-called situation model building processes have been ascribed to the prefrontal cortex

  2. Model Related Estimates of time dependent quantiles of peak flows - case study for selected catchments in Poland

    Science.gov (United States)

    Strupczewski, Witold G.; Bogdanowich, Ewa; Debele, Sisay

    2016-04-01

    Under Polish climate conditions the series of Annual Maxima (AM) flows are usually a mixture of peak flows of thaw- and rainfall- originated floods. The northern, lowland regions are dominated by snowmelt floods whilst in mountainous regions the proportion of rainfall floods is predominant. In many stations the majority of AM can be of snowmelt origin, but the greatest peak flows come from rainfall floods or vice versa. In a warming climate, precipitation is less likely to occur as snowfall. A shift from a snow- towards a rain-dominated regime results in a decreasing trend in mean and standard deviations of winter peak flows whilst rainfall floods do not exhibit any trace of non-stationarity. That is why a simple form of trends (i.e. linear trends) are more difficult to identify in AM time-series than in Seasonal Maxima (SM), usually winter season time-series. Hence it is recommended to analyse trends in SM, where a trend in standard deviation strongly influences the time -dependent upper quantiles. The uncertainty associated with the extrapolation of the trend makes it necessary to apply a relationship for trend which has time derivative tending to zero, e.g. we can assume a new climate equilibrium epoch approaching, or a time horizon is limited by the validity of the trend model. For both winter and summer SM time series, at least three distributions functions with trend model in the location, scale and shape parameters are estimated by means of the GAMLSS package using the ML-techniques. The resulting trend estimates in mean and standard deviation are mutually compared to the observed trends. Then, using AIC measures as weights, a multi-model distribution is constructed for each of two seasons separately. Further, assuming a mutual independence of the seasonal maxima, an AM model with time-dependent parameters can be obtained. The use of a multi-model approach can alleviate the effects of different and often contradictory trends obtained by using and identifying

  3. Development of an Anatomically Accurate Finite Element Human Ocular Globe Model for Blast-Related Fluid-Structure Interaction Studies

    Science.gov (United States)

    2017-02-01

    primary blast wave loading on the eye. Watson et al.16 evaluated primary blast wave insult through a combined experimental-computational approach...analysis model of orbital biomechanics. Vision Res. 2006;46(11):1724–1731. 16. Watson R, Gray W, Sponsel WE, Lund BJ, Glickman RD, Groth SL, Reilly MA...ISRN Ophthalmology; 2011. Article ID No.: 146813. doi:10.5402/2011/146813. 39. Roberts KF, Artes PH, OLeary N, Reis AS, Sharpe GP, Hutchison DM

  4. An F2 pig resource population as a model for genetic studies of obesity and obesity-related diseases in humans

    DEFF Research Database (Denmark)

    Kogelman, Lisette; Kadarmideen, Haja; Mark, Thomas

    2013-01-01

    Obesity is a rising worldwide public health problem. Difficulties to precisely measure various obesity traits and the genetic heterogeneity in human have been major impediments to completely disentangle genetic factors causing obesity. The pig is a relevant model for studying human obesity...... and obesity-related (OOR) traits. Using founder breeds divergent with respect to obesity traits we have created an F2 pig resource population (454 pigs), which has been intensively phenotyped for 36 OOR traits. The main rationale for our study is to characterize the genetic architecture of OOR traits in the F...

  5. Examining a comprehensive model of disaster-related posttraumatic stress disorder in systematically studied survivors of 10 disasters.

    Science.gov (United States)

    North, Carol S; Oliver, Julianne; Pandya, Anand

    2012-10-01

    Using a comprehensive disaster model, we examined predictors of posttraumatic stress disorder (PTSD) in combined data from 10 different disasters. The combined sample included data from 811 directly exposed survivors of 10 disasters between 1987 and 1995. We used consistent methods across all 10 disaster samples, including full diagnostic assessment. In multivariate analyses, predictors of PTSD were female gender, younger age, Hispanic ethnicity, less education, ever-married status, predisaster psychopathology, disaster injury, and witnessing injury or death; exposure through death or injury to friends or family members and witnessing the disaster aftermath did not confer additional PTSD risk. Intentionally caused disasters associated with PTSD in bivariate analysis did not independently predict PTSD in multivariate analysis. Avoidance and numbing symptoms represented a PTSD marker. Despite confirming some previous research findings, we found no associations between PTSD and disaster typology. Prospective research is needed to determine whether early avoidance and numbing symptoms identify individuals likely to develop PTSD later. Our findings may help identify at-risk populations for treatment research.

  6. A Transgenic Mouse Model for Studying the Role of the Parathyroid Hormone-Related Protein System in Renal Injury

    Directory of Open Access Journals (Sweden)

    Ricardo J. Bosch

    2011-01-01

    Full Text Available Parathyroid hormone- (PTH- related protein (PTHrP and its receptor, the PTH1 receptor (PTH1R, are widely expressed in the kidney, where PTHrP exerts a modulatory action on renal function. PTHrP is known to be upregulated in several experimental nephropathies such as acute renal failure (ARF, obstructive nephropathy (ON as well as diabetic nephropathy (DN. In this paper, we will discuss the functional consequences of chronic PTHrP overexpression in the damaged kidney using a transgenic mouse strain overexpressing PTHrP in the renal proximal tubule. In both ARF and ON, PTHrP displays proinflammatory and profibrogenic actions including the induction of epithelia to mesenquima transition. Moreover, PTHrP participates in the mechanisms of renal hypertrophy as well as proteinuria in experimental DN. Angiotensin II (Ang II, a critical factor in the progression of renal injury, appears to be, at least in part, responsible for endogenous PTHrP upregulation in these pathophysiological settings. These findings provide novel insights into the well-known protective effects of Ang II antagonists in renal diseases, paving the way for new therapeutic approaches.

  7. A transgenic mouse model for studying the role of the parathyroid hormone-related protein system in renal injury.

    Science.gov (United States)

    Bosch, Ricardo J; Ortega, Arantxa; Izquierdo, Adriana; Arribas, Ignacio; Bover, Jordi; Esbrit, Pedro

    2011-01-01

    Parathyroid hormone- (PTH-) related protein (PTHrP) and its receptor, the PTH1 receptor (PTH1R), are widely expressed in the kidney, where PTHrP exerts a modulatory action on renal function. PTHrP is known to be upregulated in several experimental nephropathies such as acute renal failure (ARF), obstructive nephropathy (ON) as well as diabetic nephropathy (DN). In this paper, we will discuss the functional consequences of chronic PTHrP overexpression in the damaged kidney using a transgenic mouse strain overexpressing PTHrP in the renal proximal tubule. In both ARF and ON, PTHrP displays proinflammatory and profibrogenic actions including the induction of epithelia to mesenquima transition. Moreover, PTHrP participates in the mechanisms of renal hypertrophy as well as proteinuria in experimental DN. Angiotensin II (Ang II), a critical factor in the progression of renal injury, appears to be, at least in part, responsible for endogenous PTHrP upregulation in these pathophysiological settings. These findings provide novel insights into the well-known protective effects of Ang II antagonists in renal diseases, paving the way for new therapeutic approaches.

  8. The Figure 8 Model of International Relations

    National Research Council Canada - National Science Library

    Sibayan, Jerome T

    2008-01-01

    .... The Figure 8 Model is presented first in a Cartesian format and then in geometrical form. This model is an intuitive idea based on a particular reading of history rather than a new international relations theory...

  9. Existing Model Metrics and Relations to Model Quality

    OpenAIRE

    Mohagheghi, Parastoo; Dehlen, Vegard

    2009-01-01

    This paper presents quality goals for models and provides a state-of-the-art analysis regarding model metrics. While model-based software development often requires assessing the quality of models at different abstraction and precision levels and developed for multiple purposes, existing work on model metrics do not reflect this need. Model size metrics are descriptive and may be used for comparing models but their relation to model quality is not welldefined. Code metrics are proposed to be ...

  10. Thinking Relationally about Studying "Up"

    Science.gov (United States)

    Stich, Amy E.; Colyar, Julia E.

    2015-01-01

    In this paper, the authors argue that despite a resurgence of elite studies, the majority of existing scholarship works to reify and legitimize social inequality through its language and method. In particular, the authors utilize Pierre Bourdieu's concept of relational thinking to review and critique contemporary research on elite education and…

  11. Relating derived relations as a model of analogical reasoning: reaction times and event-related potentials.

    Science.gov (United States)

    Barnes-Holmes, Dermot; Regan, Donal; Barnes-Holmes, Yvonne; Commins, Sean; Walsh, Derek; Stewart, Ian; Smeets, Paul M; Whelan, Robert; Dymond, Simon

    2005-11-01

    The current study aimed to test a Relational Frame Theory (RFT) model of analogical reasoning based on the relating of derived same and derived difference relations. Experiment 1 recorded reaction time measures of similar-similar (e.g., "apple is to orange as dog is to cat") versus different-different (e.g., "he is to his brother as chalk is to cheese") derived relational responding, in both speed-contingent and speed-noncontingent conditions. Experiment 2 examined the event-related potentials (ERPs) associated with these two response patterns. Both experiments showed similar-similar responding to be significantly faster than different-different responding. Experiment 2 revealed significant differences between the waveforms of the two response patterns in the left-hemispheric prefrontal regions; different-different waveforms were significantly more negative than similar-similar waveforms. The behavioral and neurophysiological data support the RFT prediction that, all things being equal, similar-similar responding is relationally "simpler" than, and functionally distinct from, different-different analogical responding. The ERP data were fully consistent with findings in the neurocognitive literature on analogy. These findings strengthen the validity of the RFT model of analogical reasoning and supplement the behavior-analytic approach to analogy based on the relating of derived relations.

  12. Studies in coal liquefaction with application to the SRC and related processes. Quarterly report, August 1981-October 1981. [Using model compounds

    Energy Technology Data Exchange (ETDEWEB)

    Tarrer, A. R.; Guin, J. A.; Curtis, C. W.

    1981-01-01

    Model compound reactions were studied to evaluate the effects of mass transfer, solvent type, solvent blending, hydrogen partial pressure, temperature, reactant concentration, additive loading and its preparation, etc. Naphthalene hydrogenation and benzothiophene hydrodesulfurization were investigated under the conditions comparable to commercial coal liquefaction and related processes. Both of these reaction systems were observed to be surface reaction controlled under the reaction conditions used in this work. Certain aromatic compounds were observed to cause a reduction in the reaction rates of naphthalene and benzothiophene. Single stage coal dissolution was investigated using tetralin as a hydrogen donor solvent and a commercial cobalt-molybdate catalyst. A spinning basket system was developed to allow injection of the catalyst at a desired time in the reaction cycle. This catalyst injection technique proved to be reliable for the exploratory work done here. The degree of catalyst deactivation was rated by comparing the activities of the spent catalyst for model compound (naphthalene and cumene) reactivities relative to those of the fresh catalyst. No substantial reduction in deactivation was observed to result with delayed contacting of the catalyst with the coal-tetralin reaction mixture. The effect of reaction temperature on the initial rate of catalyst deactivation was also studied.

  13. Personality, relationship conflict, and teamwork-related mental models

    NARCIS (Netherlands)

    Vîrgă, D.; Curseu, P.L.; Maricuţoiu, L.; Sava, S.A.; Macsinga, I.; Măgurean, S.

    2014-01-01

    This study seeks to explore whether neuroticism, agreeableness, and conscientiousness moderate the influence of relationship conflict experienced in groups on changes in group members' evaluative cognitions related to teamwork quality (teamwork-related mental models). Data from 216 students, nested

  14. Predictive modeling of groundwater nitrate pollution using Random Forest and multisource variables related to intrinsic and specific vulnerability: a case study in an agricultural setting (Southern Spain).

    Science.gov (United States)

    Rodriguez-Galiano, Victor; Mendes, Maria Paula; Garcia-Soldado, Maria Jose; Chica-Olmo, Mario; Ribeiro, Luis

    2014-04-01

    Watershed management decisions need robust methods, which allow an accurate predictive modeling of pollutant occurrences. Random Forest (RF) is a powerful machine learning data driven method that is rarely used in water resources studies, and thus has not been evaluated thoroughly in this field, when compared to more conventional pattern recognition techniques key advantages of RF include: its non-parametric nature; high predictive accuracy; and capability to determine variable importance. This last characteristic can be used to better understand the individual role and the combined effect of explanatory variables in both protecting and exposing groundwater from and to a pollutant. In this paper, the performance of the RF regression for predictive modeling of nitrate pollution is explored, based on intrinsic and specific vulnerability assessment of the Vega de Granada aquifer. The applicability of this new machine learning technique is demonstrated in an agriculture-dominated area where nitrate concentrations in groundwater can exceed the trigger value of 50 mg/L, at many locations. A comprehensive GIS database of twenty-four parameters related to intrinsic hydrogeologic proprieties, driving forces, remotely sensed variables and physical-chemical variables measured in "situ", were used as inputs to build different predictive models of nitrate pollution. RF measures of importance were also used to define the most significant predictors of nitrate pollution in groundwater, allowing the establishment of the pollution sources (pressures). The potential of RF for generating a vulnerability map to nitrate pollution is assessed considering multiple criteria related to variations in the algorithm parameters and the accuracy of the maps. The performance of the RF is also evaluated in comparison to the logistic regression (LR) method using different efficiency measures to ensure their generalization ability. Prediction results show the ability of RF to build accurate models

  15. Lyophilized kits of diamino dithiol compounds for labelling with 99m-technetium. Pharmacokinetics studies and distribution compartmental models of the related complexes

    International Nuclear Information System (INIS)

    Araujo, Elaine Bortoleti de

    1995-01-01

    The present work reflects the clinical interest for labelling diamino dithiol compounds with technetium-99m. Both chosen compounds, L,L-Ethylene dicysteine (L,L-EC) and L,L-Ethylene dicysteine diethyl esther (L,L-ECD) were obtained with relative good yield and characterized by IR and NMR. The study of labelling conditions with technetium-99m showed the influence of the type and mass of reducing agent as well as the pH on the formation of complexes with desired biological characteristics. Radiochemical purity was determined by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC). Lyophilised kits of L,L-EC and L,L-ECD for labelling with 99m Tc were obtained, with stability superior to 120 days, when stored under refrigeration, enabling the kits marketing. The ideal formulation of the kits as well as the use of liquid nitrogen in the freezing process, determined the lyophilization success. Distribution biological studies of the 99m Tc complexes were performed on mice by invasive method and on bigger animals by scintigraphic evaluation. Biological distribution studies of the complex 99m Tc-L,L-EC showed fast blood clearance, with the elimination of about 90% of the administered dose after 60 minutes, almost exclusively by the urinary system. The biological distribution results were adjusted to a three compartmental distribution model, as expected for a radiopharmaceutical designed to renal dynamic studies, with tubular elimination. The complex interaction with renal tubular receptors is related with structural characteristics of the compound, more specifically with the presence and location of polar groups. In comparison with 99m Tc-L,L-EC, biological studies of the complex 99m Tc -L,L-ECD showed different distribution aspects, despite some structural similarities. The presence of ethyl groups confers to the complex neutrality and lipophilicity. It cross the intact blood brain barrier and is retained in the brain for enough period

  16. Maximum field emission current density of CuO nanowires: theoretical study using a defect-related semiconductor field emission model and in situ measurements.

    Science.gov (United States)

    Lin, Zufang; Zhao, Peng; Ye, Peng; Chen, Yicong; Gan, Haibo; She, Juncong; Deng, Shaozhi; Xu, Ningsheng; Chen, Jun

    2018-02-01

    In this study, we proposed a theoretical model for one-dimensional semiconductor nanowires (NWs), taking account of the defect-related electrical transport process. The maximum emission current density was calculated by considering the influence of Joule heating, using a one-dimensional heat equation. The field emission properties of individual CuO NWs with different electrical properties were studied using an in situ experimental technique. The experimental results for maximum emission current density agreed well with the theoretical predictions and suggested that multiple conduction mechanisms were active. These may be induced by the concentration of defects in the CuO NW. The concentration of defects and the transport mechanisms were found to be key factors influencing the maximum field emission current density of the semiconductor NW. As is limited by the change of resistivity with temperature, only thermal runaway can trigger breakdown in CuO NWs.

  17. The transtheoretical model and strategies of European fitness professionals to support clients in changing health-related behaviour: A survey study

    NARCIS (Netherlands)

    Middelkamp, P.J.C.; Wolfhagen, P.; Steenbergen, B.

    2015-01-01

    Introduction: The transtheoretical model of behaviour change (TTM) is often used to understand and predict changes in health related behaviour, for example exercise behaviour and eating behaviour. Fitness professionals like personal trainers typically service and support clients in improving

  18. Relating structure and dynamics in organisation models

    NARCIS (Netherlands)

    Jonkers, C.M.; Treur, J.

    2002-01-01

    To understand how an organisational structure relates to dynamics is an interesting fundamental challenge in the area of social modelling. Specifications of organisational structure usually have a diagrammatic form that abstracts from more detailed dynamics. Dynamic properties of agent systems,

  19. Pertanggungjawaban Sosial Universitas: Implementasi Model Cycle Relations

    Directory of Open Access Journals (Sweden)

    Lina Sinatra Wijaya

    2016-10-01

    Full Text Available The competition among Higher Education is getting tougher. They need to do their best in order to maintain their existence and getting more students coming to their institutions. One way to achieve that goal is through carrying out Corporate Social Responsibility (CSR programs or University Social Responsibility (USR for university. This study tries to investigate the implementation of ‘Cycle Relations’ model in CSR to increase the intake of Higher Education. This study involved seven Higher Educations and nineteen High schools in Central Java. In collecting the data, it used a depth-interview method with all the related parties in this study. The result showed that most of the Higher Education institutions have implemented Corporate Social Responsibility program in various ways. Their target audience included the high schools, society, and parents.  From the model implementation, it showed that the CSR program did have an impact towards the intake in their institution. However, one important thing to consider is that the role of the teachers at schools was quite significant in influencing the students to choose which university to go.  This reflects that although the Higher Education institution have planned and carried out CSR programs according to what the target audiences’ need, it does not guarantee that it will have direct impact towards their intake because the influence of teacher is quite significant. It may have a bigger impact in long term as the target audiences know the quality and contribution of the Higher Education institutions.

  20. Models and relations in economics and econometrics

    DEFF Research Database (Denmark)

    Juselius, Katarina

    1999-01-01

    Based on a money market analysis using the cointegrated VAR model the paper demonstrates some possible pitfalls in macroeconomic inference as a direct consequence of inadequate stochastic model formulation. A number of questions related to concepts such as empirical and theoretical steady-states,...

  1. Models and relations in economics and econometrics

    DEFF Research Database (Denmark)

    Juselius, Katarina

    1999-01-01

    Based on a money market analysis using the cointegrated VAR model the paper demonstrates some possible pitfalls in macroeconomic inference as a direct consequence of inadequate stochastic model formulation. A number of questions related to concepts such as empirical and theoretical steady...

  2. Relating business modelling and enterprise architecture

    NARCIS (Netherlands)

    Meertens, Lucas Onno

    2013-01-01

    This thesis proposes a methodology for creating business models, evaluating them, and relating them to enterprise architecture. The methodology consists of several steps, leading from an organization’s current situation to a target situation, via business models and enterprise architecture.

  3. Do objective neighbourhood characteristics relate to residents' preferences for certain sports locations? A cross-sectional study using a discrete choice modelling approach.

    Science.gov (United States)

    Deelen, Ineke; Jansen, Marijke; Dogterom, Nico J; Kamphuis, Carlijn B M; Ettema, Dick

    2017-12-11

    The number of sports facilities, sports clubs, or city parks in a residential neighbourhood may affect the likelihood that people participate in sports and their preferences for a certain sports location. This study aimed to assess whether objective physical and socio-spatial neighbourhood characteristics relate to sports participation and preferences for sports locations. Data from Dutch adults (N = 1201) on sports participation, their most-used sports location, and socio-demographic characteristics were collected using an online survey. Objective land-use data and the number of sports facilities were gathered for each participant using a 2000-m buffer around their home locations, whereas socio-spatial neighbourhood characteristics (i.e., density, socio-economic status, and safety) were determined at the neighbourhood level. A discrete choice-modelling framework (multinomial probit model) was used to model the associations between neighbourhood characteristics and sports participation and location. Higher proportions of green space, blue space, and the number of sports facilities were positively associated with sports participation in public space, at sports clubs, and at other sports facilities. Higher degrees of urbanization were negatively associated with sports participation at public spaces, sports clubs, and other sports facilities. Those with more green space, blue space or sports facilities in their residential neighbourhood were more likely to participate in sports, but these factors did not affect their preference for a certain sports location. Longitudinal study designs are necessary to assess causality: do active people choose to live in sports-facilitating neighbourhoods, or do neighbourhood characteristics affect sports participation?

  4. The Study of Pap Smear Conduction and its Related Factors Based on Health Belief Model in Women Referring to Health Care Centers in Qom During 2014

    Directory of Open Access Journals (Sweden)

    Siamak Mohebi*

    2016-03-01

    Full Text Available Background and Objectives: Pap smear is a screening test for diagnosing cervical cancer in females. It is considered a health-promotion exam, and it has been shown that this test can prevent up to %60 of all deaths resulting from cervical cancer. The present study aimed to determine the prevalence of this test and its related factors based on the health belief model in females referring to health centers in Qom. Materials and Methods: In this cross-sectional study, 320 females, who had health records and had referred to health centers in Qom in 2014 were selected using the multistage random sampling method and through following inclusion and exclusion criteria. A valid and reliable researcher-made questionnaire consisting of demographic characteristics, awareness questions, and questions based on the health belief model was used for data collection. The data were finally analyzed by SPSS software with 0.05 significance level. Results: Overall, %11.25 of the subjects regularly underwent Pap smear screening, %51.87 irregularly participated in cervical cancer screening programs, and %36.88 did not undergo the tests. Analysis of Variance (ANOVA results showed that the mean scores of the health belief model constructs were significantly different in terms of Pap smear screening (P<0.05. Conclusion: The participants did not consider cervical cancer a serious disease. Even women who felt vulnerable tried to hide it. Therefore, while perceived vulnerability and perceived severity of the disease risk was low in them, they perceived more barriers and, for this reason, the level of utilization of Pap smear was undesirable.

  5. Personality-related factors as predictors of help-seeking for depression: a population-based study applying the Behavioral Model of Health Services Use.

    Science.gov (United States)

    Schomerus, Georg; Appel, Katja; Meffert, Peter J; Luppa, Melanie; Andersen, Ronald M; Grabe, Hans J; Baumeister, Sebastian E

    2013-11-01

    Although the prevalence of mental disorders and the demand for mental health services are increasing, little is known about the impact of personality-related factors on help-seeking among depressive individuals. We, therefore, investigated the relationship between the "Big Five" personality traits, resilience, alexithymia, childhood neglect or abuse, and help-seeking among depressive individuals. We used data from 354 persons with a diagnosis of major depression from the population-based cohort study of health in Pomerania within the theoretical framework of the Andersen Behavioral Model of Health Services Use. Using stepwise regression techniques, we found that older age, higher education, more perceived social support, presence of childhood abuse, higher levels of conscientiousness, lower levels of resilience, and more severe depression were associated with help-seeking for depression. In contrast, gender, extraversion, openness, agreeableness, neuroticism, and alexithymia did not significantly predict help-seeking. In addition, no evidence for gender-specific effects was observed. Personality-related predisposing factors are important predictors of help-seeking. The influence of resilience on help-seeking among depressed individuals merits further exploration.

  6. Anterior cingulate cortex-related connectivity in first-episode schizophrenia: a spectral dynamic causal modeling study with functional magnetic resonance imaging

    Directory of Open Access Journals (Sweden)

    Long-Biao eCui

    2015-11-01

    Full Text Available Understanding the neural basis of schizophrenia (SZ is important for shedding light on the neurobiological mechanisms underlying this mental disorder. Structural and functional alterations in the anterior cingulate cortex (ACC, dorsolateral prefrontal cortex (DLPFC, hippocampus, and medial prefrontal cortex (MPFC have been implicated in the neurobiology of SZ. However, the effective connectivity among them in SZ remains unclear. The current study investigated how neuronal pathways involving these regions were affected in first-episode SZ using functional magnetic resonance imaging (fMRI. Forty-nine patients with a first-episode of psychosis and diagnosis of SZ—according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision—were studied. Fifty healthy controls (HCs were included for comparison. All subjects underwent resting state fMRI. We used spectral dynamic causal modeling (DCM to estimate directed connections among the bilateral ACC, DLPFC, hippocampus, and MPFC. We characterized the differences using Bayesian parameter averaging (BPA in addition to classical inference (t-test. In addition to common effective connectivity in these two groups, HCs displayed widespread significant connections predominantly involved in ACC not detected in SZ patients, but SZ showed few connections. Based on BPA results, SZ patients exhibited anterior cingulate cortico-prefrontal-hippocampal hyperconnectivity, as well as ACC-related and hippocampal-dorsolateral prefrontal-medial prefrontal hypoconnectivity. In summary, sDCM revealed the pattern of effective connectivity involving ACC in patients with first-episode SZ. This study provides a potential link between SZ and dysfunction of ACC, creating an ideal situation to associate mechanisms behind SZ with aberrant connectivity among these cognition and emotion-related regions.

  7. Cross-lagged structural equation models for the relationship between health-related state and behaviours and body bullying in adolescence: findings from longitudinal study ELANA.

    Directory of Open Access Journals (Sweden)

    Viviane S Straatmann

    Full Text Available We investigated the stability and the directionality of being body bullied and a set of four variables- 1 Body Mass Index (BMI, 2 moderate and vigorous physical activity (MVPA, 3 television time (TV and 4 video game/computer time (VG-, termed in the present study as 'health-related state and behaviours (HRSB'-across adolescence. The Adolescent Nutritional Assessment Longitudinal Study (ELANA is a cohort study conducted among middle school students from two public and four private schools in Rio de Janeiro-Brazil. We analysed data from 2010 (T1 and 2012 (T2 among 810 adolescents (aged 9-15 at T1. Gender-specific structural equation models (SEM were estimated, including autoregressive paths for the HRSB and being body bullied over time, correlations at T1 and T2, respectively, and cross-lagged effects. The results presented significant stability coefficients for almost all variables over time in both genders (except for MVPA in boys and girls and TV time among girls. There were positive correlations between BMI and being body bullied, as well as between TV and VG for boys (0.32, p<0.001 and 0.24, p<0.001, respectively and girls (0.30, p<0.001 and 0.30, p<0.001, respectively at T1. It remained significant at T2 (boys: 0.18, p<0.05 and 0.16, p<0.01; girls: 0.21, p<0.01 and 0.22, p<0.01, respectively. Examining the cross-lagged paths between being body bullied and HRSB, we observed that the reciprocal model provided the best fit for boys, indicating that BMI at T1 had a significant effect in being body bullied at T2 (0.12, p<0.05 and being body bullied at T1 had an effect on VG at T2 (0.14, p<0.01. Among girls the forward causation model showed the best fit, demonstrating a significant effect of being body bullied at T1 on VG at T2 (0.16, p<0.01. Apart from MVPA, both being body bullying and HRSB were largely stable across adolescence. For boys and girls alike, exposure to being body bullied seemed to increase their time spent on VG, while for boys

  8. Collagen osteoid-like model allows kinetic gene expression studies of non-collagenous proteins in relation with mineral development to understand bone biomineralization.

    Directory of Open Access Journals (Sweden)

    Jérémie Silvent

    Full Text Available Among persisting questions on bone calcification, a major one is the link between protein expression and mineral deposition. A cell culture system is here proposed opening new integrative studies on biomineralization, improving our knowledge on the role played by non-collagenous proteins in bone. This experimental in vitro model consisted in human primary osteoblasts cultured for 60 days at the surface of a 3D collagen scaffold mimicking an osteoid matrix. Various techniques were used to analyze the results at the cellular and molecular level (adhesion and viability tests, histology and electron microscopy, RT- and qPCR and to characterize the mineral phase (histological staining, EDX, ATG, SAED and RMN. On long term cultures human bone cells seeded on the osteoid-like matrix displayed a clear osteoblast phenotype as revealed by the osteoblast-like morphology, expression of specific protein such as alkaline phosphatase and expression of eight genes classically considered as osteoblast markers, including BGLAP, COL1A1, and BMP2. Von Kossa and alizarine red allowed us to identify divalent calcium ions at the surface of the matrix, EDX revealed the correct Ca/P ratio, and SAED showed the apatite crystal diffraction pattern. In addition RMN led to the conclusion that contaminant phases were absent and that the hydration state of the mineral was similar to fresh bone. A temporal correlation was established between quantified gene expression of DMP1 and IBSP, and the presence of hydroxyapatite, confirming the contribution of these proteins to the mineralization process. In parallel a difference was observed in the expression pattern of SPP1 and BGLAP, which questioned their attributed role in the literature. The present model opens new experimental possibilities to study spatio-temporal relations between bone cells, dense collagen scaffolds, NCPs and hydroxyapatite mineral deposition. It also emphasizes the importance of high collagen density

  9. Gratitude depends on the relational model of communal sharing.

    Science.gov (United States)

    Simão, Cláudia; Seibt, Beate

    2014-01-01

    We studied the relation between benefits, perception of social relationships and gratitude. Across three studies, we provide evidence that benefits increase gratitude to the extent to which one applies a mental model of a communal relationship. In Study 1, the communal sharing relational model, and no other relational models, predicted the amount of gratitude participants felt after imagining receiving a benefit from a new acquaintance. In Study 2, participants recalled a large benefit they had received. Applying a communal sharing relational model increased feelings of gratitude for the benefit. In Study 3, we manipulated whether the participant or another person received a benefit from an unknown other. Again, we found that the extent of communal sharing perceived in the relationship with the stranger predicted gratitude. An additional finding of Study 2 was that communal sharing predicted future gratitude regarding the relational partner in a longitudinal design. To conclude, applying a communal sharing model predicts gratitude regarding concrete benefits and regarding the relational partner, presumably because one perceives the communal partner as motivated to meet one's needs. Finally, in Study 3, we found in addition that being the recipient of a benefit without opportunity to repay directly increased communal sharing, and indirectly increased gratitude. These circumstances thus seem to favor the attribution of communal norms, leading to a communal sharing representation and in turn to gratitude. We discuss the importance of relational models as mental representations of relationships for feelings of gratitude.

  10. Cross-lagged structural equation models for the relationship between health-related state and behaviours and body bullying in adolescence: findings from longitudinal study ELANA.

    Science.gov (United States)

    Straatmann, Viviane S; Almquist, Ylva B; Oliveira, Aldair J; Rostila, Mikael; Lopes, Claudia S

    2018-01-01

    We investigated the stability and the directionality of being body bullied and a set of four variables- 1) Body Mass Index (BMI), 2) moderate and vigorous physical activity (MVPA), 3) television time (TV) and 4) video game/computer time (VG)-, termed in the present study as 'health-related state and behaviours (HRSB)'-across adolescence. The Adolescent Nutritional Assessment Longitudinal Study (ELANA) is a cohort study conducted among middle school students from two public and four private schools in Rio de Janeiro-Brazil. We analysed data from 2010 (T1) and 2012 (T2) among 810 adolescents (aged 9-15 at T1). Gender-specific structural equation models (SEM) were estimated, including autoregressive paths for the HRSB and being body bullied over time, correlations at T1 and T2, respectively, and cross-lagged effects. The results presented significant stability coefficients for almost all variables over time in both genders (except for MVPA in boys and girls and TV time among girls). There were positive correlations between BMI and being body bullied, as well as between TV and VG for boys (0.32, peffect in being body bullied at T2 (0.12, peffect on VG at T2 (0.14, peffect of being body bullied at T1 on VG at T2 (0.16, p<0.01). Apart from MVPA, both being body bullying and HRSB were largely stable across adolescence. For boys and girls alike, exposure to being body bullied seemed to increase their time spent on VG, while for boys BMI also predicted being body bullied. This study highlighted the complex interplay between being body bullied and HRSB and the importance of acknowledging gender differences in this context.

  11. RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.

    Science.gov (United States)

    Fang, Bingliang

    2016-01-01

    Activating mutations of oncogenic RAS genes are frequently detected in human cancers. The studies in genetically engineered mouse models (GEMMs) reveal that Kras-activating mutations predispose mice to early onset tumors in the lung, pancreas, and gastrointestinal tract. Nevertheless, most of these tumors do not have metastatic phenotypes. Metastasis occurs when tumors acquire additional genetic changes in other cancer driver genes. Studies on clinical specimens also demonstrated that KRAS mutations are present in premalignant tissues and that most of KRAS mutant human cancers have co-mutations in other cancer driver genes, including TP53, STK11, CDKN2A, and KMT2C in lung cancer; APC, TP53, and PIK3CA in colon cancer; and TP53, CDKN2A, SMAD4, and MED12 in pancreatic cancer. Extensive efforts have been devoted to develop therapeutic agents that target enzymes involved in RAS posttranslational modifications, that inhibit downstream effectors of RAS signaling pathways, and that kill RAS mutant cancer cells through synthetic lethality. Recent clinical studies have revealed that sorafenib, a pan-RAF and VEGFR inhibitor, has impressive benefits for KRAS mutant lung cancer patients. Combination therapy of MEK inhibitors with either docetaxel, AKT inhibitors, or PI3K inhibitors also led to improved clinical responses in some KRAS mutant cancer patients. This review discusses knowledge gained from GEMMs, human cancer cells, and patient-related studies on RAS-mediated tumorigenesis and anti-RAS therapy. Emerging evidence demonstrates that RAS mutant cancers are heterogeneous because of the presence of different mutant alleles and/or co-mutations in other cancer driver genes. Effective subclassifications of RAS mutant cancers may be necessary to improve patients' outcomes through personalized precision medicine. © The Author 2015. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology

  12. Models of Man in Industrial Relations Research.

    Science.gov (United States)

    Kaufman, Bruce E.; And Others

    1989-01-01

    Kaufman attempts to identify essential characteristics that distinguish behavioral from nonbehavioral research in industrial relations. He argues that they are distinguished by the psychological model of man that is contained in the theoretical framework used to deduce or test hypotheses. Comments from Lewin, Mincer, and Cummings with Kaufman's…

  13. Relating structure and dynamics in organisation models

    NARCIS (Netherlands)

    Jonker, C.M.; Treur, J.

    2003-01-01

    To understand how an organisational structure relates to dynamics is an interesting fundamental challenge in the area of social modelling. Specifications of organisational structure usually have a diagrammatic form that abstracts from more detailed dynamics. Dynamic properties of agent systems, on

  14. Modeling behavioral considerations related to information security.

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Moyano, I. J.; Conrad, S. H.; Andersen, D. F. (Decision and Information Sciences); (SNL); (Univ. at Albany)

    2011-01-01

    The authors present experimental and simulation results of an outcome-based learning model for the identification of threats to security systems. This model integrates judgment, decision-making, and learning theories to provide a unified framework for the behavioral study of upcoming threats.

  15. Relative effectiveness of assertive training, modelling and their ...

    African Journals Online (AJOL)

    The study investigated the Relative Effectiveness of Assertive Training (AT), modelling (M) and a combination of Assertive Training and Modelling (AT & M) techniques in improving the social skills of primary school isolates and consequently reduce their isolate behaviour. The study is a quasi experimental research that ...

  16. Rationale and approaches to the prevention of smoking-related diseases: overview of recent studies on chemoprevention of smoking-induced tumors in rodent models.

    Science.gov (United States)

    De Flora, Silvio; Izzotti, Alberto; D'Agostini, Francesco; La Maestra, Sebastiano; Micale, Rosanna T; Ceccaroli, Chiara; Steele, Vernon E; Balansky, Roumen

    2014-01-01

    Tobacco smoke plays a dominant role in the epidemiology of lung cancer, cancer at other sites, and a variety of other chronic diseases. It is the leading cause of death in developed countries, and the global burden of cancer is escalating in less developed regions. For a rational implementation of strategies exploitable for the prevention smoking-related diseases, it is crucial to elucidate both the mechanisms of action of cigarette smoke and the protective mechanisms of the host organism. The imperative primary prevention goal is to avoid any type of exposure to smoke. Epidemiological studies have shown that a decrease in the consumption of cigarettes can be successful in attenuating the epidemic of lung cancer in several countries. Chemoprevention by means of dietary and/or pharmacological agents provides a complementary strategy aimed at decreasing the risk of developing smoking-associated diseases in addicted current smokers, who are unable to quit smoking, and especially in involuntary smokers and ex-smokers. The availability of new animal models that are suitable to detect the carcinogenicity of cigarette smoke and to assess the underlying molecular mechanisms provides new tools for evaluating both safety and efficacy of putative chemopreventive agents.

  17. Relative Motion Modeling and Autonomous Navigation Accuracy

    Science.gov (United States)

    2016-11-15

    the use of nonsingular elements, this version of relative motion STM has singularities for reference orbits that lie in the equatorial plane ...improved by including the lunar orbit’s eccentricity and inclination in the studies presented in References [17-19]. Since the perturbed relative motion ...satellites are equipped with solar flaps or aerodynamic flaps. By appropriate rotation of these flaps, it is possible to influence the relative motion

  18. Parkinson Symptoms and Health Related Quality of Life as Predictors of Costs: A Longitudinal Observational Study with Linear Mixed Model Analysis.

    Directory of Open Access Journals (Sweden)

    Pablo Martinez-Martín

    Full Text Available To estimate the magnitude in which Parkinson's disease (PD symptoms and health- related quality of life (HRQoL determined PD costs over a 4-year period.Data collected during 3-month, each year, for 4 years, from the ELEP study, included sociodemographic, clinical and use of resources information. Costs were calculated yearly, as mean 3-month costs/patient and updated to Spanish €, 2012. Mixed linear models were performed to analyze total, direct and indirect costs based on symptoms and HRQoL.One-hundred and seventy four patients were included. Mean (SD age: 63 (11 years, mean (SD disease duration: 8 (6 years. Ninety-three percent were HY I, II or III (mild or moderate disease. Forty-nine percent remained in the same stage during the study period. Clinical evaluation and HRQoL scales showed relatively slight changes over time, demonstrating a stable group overall. Mean (SD PD total costs augmented 92.5%, from € 2,082.17 (€ 2,889.86 in year 1 to € 4,008.6 (€ 7,757.35 in year 4. Total, direct and indirect cost incremented 45.96%, 35.63%, and 69.69% for mild disease, respectively, whereas increased 166.52% for total, 55.68% for direct and 347.85% for indirect cost in patients with moderate PD. For severe patients, cost remained almost the same throughout the study. For each additional point in the SCOPA-Motor scale total costs increased € 75.72 (p = 0.0174; for each additional point on SCOPA-Motor and the SCOPA-COG, direct costs incremented € 49.21 (p = 0.0094 and € 44.81 (p = 0.0404, respectively; and for each extra point on the pain scale, indirect costs increased € 16.31 (p = 0.0228.PD is an expensive disease in Spain. Disease progression and severity as well as motor and cognitive dysfunctions are major drivers of costs increments. Therapeutic measures aimed at controlling progression and symptoms could help contain disease expenses.

  19. Validation of risk prediction models for the development of HBV-related HCC: a retrospective multi-center 10-year follow-up cohort study.

    Science.gov (United States)

    Seo, Yeon Seok; Jang, Byoung Kuk; Um, Soon Ho; Hwang, Jae Seok; Han, Kwang-Hyub; Kim, Sang Gyune; Lee, Kwan Sik; Kim, Seung Up; Kim, Young Seok; Lee, Jung Il

    2017-12-22

    Recently, modified REACH-B (mREACH-B) risk prediction model for hepatocellular carcinoma (HCC) development was proposed. We validated the accuracy of the mREACH-B model and compared its accuracy with those of other prediction models. Between 2006 and 2012, 1,241 patients with chronic hepatitis B (CHB) were recruited. All patients underwent transient elastography at enrollment. The median age of the study population (840 males, 401 females) was 49 years. The median PAGE-B, LSM-HCC, and mREACH-B values were 10, 10, and 8, respectively. Among patients without cirrhosis ( n = 940, 75.7%), the median REACH-B value was 9. During the follow-up period (median 77.4 months), 66 (5.3%) and 83 (6.7%) patients developed HCC and liver-related events (LRE), respectively. Higher liver stiffness (LS) independently predicted HCC (hazard ratio [HR] = 1.047) and LRE development (HR = 1.047) (all P HCC (AUC = 0.824 at 3-year and 0.750 at 5-year) and LRE development (AUC = 0.782 at 3-year and 0.739 at 5-year) (all P HCC (AUC = 0.715-0.809 at 3-year and 0.719-0.742 at 5-year for HCC; AUC = 0.704-0.777 at 3-year and 0.721-0.735 at 5-year for LRE). Among patients without cirrhosis, mREACH-B predicted HCC (AUC = 0.803 vs. 0.654-0.816 at 3-year and 0.684 vs. 0.639-0.738 at 5-year) and LRE development (AUC = 0.734 vs. 0.619-0.789 at 3-year and 0.674 vs. 0.626-0.729 at 5-year) similarly to PAGE-B, REACH-B, and LSM-HCC. mREACH-B appropriately predicted HCC and LRE development in patients with CHB and showed similar or superior accuracy to those of PAGE-B, REACH-B, and LSM-HCC.

  20. Animal models of age related macular degeneration

    Science.gov (United States)

    Pennesi, Mark E.; Neuringer, Martha; Courtney, Robert J.

    2013-01-01

    Age related macular degeneration (AMD) is the leading cause of vision loss of those over the age of 65 in the industrialized world. The prevalence and need to develop effective treatments for AMD has lead to the development of multiple animal models. AMD is a complex and heterogeneous disease that involves the interaction of both genetic and environmental factors with the unique anatomy of the human macula. Models in mice, rats, rabbits, pigs and non-human primates have recreated many of the histological features of AMD and provided much insight into the underlying pathological mechanisms of this disease. In spite of the large number of models developed, no one model yet recapitulates all of the features of human AMD. However, these models have helped reveal the roles of chronic oxidative damage, inflammation and immune dysregulation, and lipid metabolism in the development of AMD. Models for induced choroidal neovascularization have served as the backbone for testing new therapies. This article will review the diversity of animal models that exist for AMD as well as their strengths and limitations. PMID:22705444

  1. A Ninth Grade Student Transition Model: A Study of Student Perceptions Related to Rigor, Relevancy, and Relationships within a Ninth Grade Transitional Program

    Science.gov (United States)

    Shimp, Timothy M.

    2017-01-01

    This descriptive case study is a qualitative investigation into the perceptions of tenth grade students who experienced a ninth-grade transitional model high school academy within a large PreK-12 suburban school district. Specifically, this study provided the opportunity to examine the success of one Ninth Grade Academy, identify areas of concern…

  2. Study of the association of atmospheric temperature and relative humidity with bulk tank milk somatic cell count in dairy herds using Generalized additive mixed models.

    Science.gov (United States)

    Testa, Francesco; Marano, Giuseppe; Ambrogi, Federico; Boracchi, Patrizia; Casula, Antonio; Biganzoli, Elia; Moroni, Paolo

    2017-10-01

    Elevated bulk tank milk somatic cell count (BMSCC) has a negative impact on milk production, milk quality, and animal health. Seasonal increases in herd level somatic cell count (SCC) are commonly associated with elevated environmental temperature and humidity. The Temperature Humidity Index (THI) has been developed to measure general environmental stress in dairy cattle; however, additional work is needed to determine a specific effect of the heat stress index on herd-level SCC. Generalized Additive Model methods were used for a flexible exploration of the relationships between daily temperature, relative humidity, and bulk milk somatic cell count. The data consist of BMSCC and meteorological recordings collected between March 2009 and October 2011 of 10 dairy farms. The results indicate that, an average increase of 0.16% of BMSCC is expected for an increase of 1°C degree of temperature. A complex relationship was found for relative humidity. For example, increase of 0.099%, 0.037% and 0.020% are expected in correspondence to an increase of relative humidity from 50% to 51%, 80% to 81%; and 90% to 91%, respectively. Using this model, it will be possible to provide evidence-based advice to dairy farmers for the use of THI control charts created on the basis of our statistical model. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Constitutive relations for multiphase flow modeling

    Energy Technology Data Exchange (ETDEWEB)

    Jacobs, H.; Vaeth, L.; Thurnay, K. [Forschungszentrum Karlsruhe GmbH Technik und Umwelt (Germany). Inst. fuer Neutronenphysik und Reaktortechnik

    1998-01-01

    The constitutive relations that are used in the three-field fluid dynamics code IVA-KA for determining the drag in three-phase mixtures and the heat transferred by radiation are described together with some comparisons of calculational results with experiments. In these experiments (QUEOS), large quantities of solid particles are injected into water. Potential deficiencies of the present drag model are discussed. (author)

  4. Studying Intergroup Relations in Organizations.

    Science.gov (United States)

    1980-01-10

    Psychology and Intergroup Relations. London; Academic Press, 1976. Bion , Wilfred R.: Experiences in Groups. New York; Basic Books, 1961. Blake... Bion , 1961; Bradford, Gibb and Benne, 1964; Rice, 1965; Gibhard, Hartman, and Mann, 1974; Cooper and Alderfer, 1978; Alderfer and Cooper, 1980

  5. Learning Statistical Patterns in Relational Data Using Probabilistic Relational Models

    National Research Council Canada - National Science Library

    Koller, Daphne

    2005-01-01

    .... This effort focused on developing undirected probabilistic models for representing and learning graph patterns, learning patterns involving links between objects, learning discriminative models...

  6. Note on off-shell relations in nonlinear sigma model

    International Nuclear Information System (INIS)

    Chen, Gang; Du, Yi-Jian; Li, Shuyi; Liu, Hanqing

    2015-01-01

    In this note, we investigate relations between tree-level off-shell currents in nonlinear sigma model. Under Cayley parametrization, all odd-point currents vanish. We propose and prove a generalized U(1) identity for even-point currents. The off-shell U(1) identity given in http://dx.doi.org/10.1007/JHEP01(2014)061 is a special case of the generalized identity studied in this note. The on-shell limit of this identity is equivalent with the on-shell KK relation. Thus this relation provides the full off-shell correspondence of tree-level KK relation in nonlinear sigma model.

  7. relative effectiveness of assertive training, modelling and their

    African Journals Online (AJOL)

    Elizabeth Egbochuku

    Imo State University. Owerri e-mail: timasy.ikenegbu@yahoo.com. Abstract. The study investigated the Relative Effectiveness of Assertive Training (AT), modelling (M) and ... conversation skills; assertiveness skills, play interaction skills; self-related ... possession of poor, inefficient or inadequate social skills, low self-esteem,.

  8. The internal model: A study of the relative contribution of proprioception and visual information to failure detection in dynamic systems. [sensitivity of operators versus monitors to failures

    Science.gov (United States)

    Kessel, C.; Wickens, C. D.

    1978-01-01

    The development of the internal model as it pertains to the detection of step changes in the order of control dynamics is investigated for two modes of participation: whether the subjects are actively controlling those dynamics or are monitoring an autopilot controlling them. A transfer of training design was used to evaluate the relative contribution of proprioception and visual information to the overall accuracy of the internal model. Sixteen subjects either tracked or monitored the system dynamics as a 2-dimensional pursuit display under single task conditions and concurrently with a sub-critical tracking task at two difficulty levels. Detection performance was faster and more accurate in the manual as opposed to the autopilot mode. The concurrent tracking task produced a decrement in detection performance for all conditions though this was more marked for the manual mode. The development of an internal model in the manual mode transferred positively to the automatic mode producing enhanced detection performance. There was no transfer from the internal model developed in the automatic mode to the manual mode.

  9. Study of the serum levels of polyunsaturated fatty acids and the expression of related liver metabolic enzymes in a rat valproate-induced autism model.

    Science.gov (United States)

    Zhao, Gang; Gao, Jingquan; Liang, Shuang; Wang, Xuelai; Sun, Caihong; Xia, Wei; Hao, Yanqiu; Li, Xiang; Cao, Yonggang; Wu, Lijie

    2015-08-01

    To investigate whether the decreased level of serum polyunsaturated fatty acids (PUFAs) in patients with autism is associated with the expression of related liver metabolic enzymes, we selected rats that were exposed to valproic acid (VPA) on embryonic day 12.5 (E12.5) as a model of autism. We observed the serum levels of PUFAs and the expression of related liver metabolic enzymes, including Δ5-desaturase, Δ6-desaturase and elongase (Elovl2), in VPA-exposed and control rats on postnatal day 35 (PND35) and conducted sex dimorphic analysis. We found that the levels of serum PUFAs and related liver metabolic enzymes in the VPA rats were significantly reduced, in association with autism-like behavioral changes, the abnormal expression of apoptosis-related proteins and hippocampal neuronal injury, compared to the control rats and showed sex difference in VPA group. This finding indicated that rats exposed to VPA at the embryonic stage may exhibit reduced synthesis of serum PUFAs due to the down-regulation of liver metabolic enzymes, thereby inducing nervous system injury and behavioral changes, which is affected by sex in the meantime. Copyright © 2015 ISDN. Published by Elsevier Ltd. All rights reserved.

  10. INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY: Mechanochemical Coupling of Kinesin Studied with a Neck-Linker Swing Model

    Science.gov (United States)

    Li, Ming; Shu, Yao-Gen; Ou-Yang, Zhong-Can

    2009-06-01

    A neck-linker swing model has been proposed in this work to investigate the mechanochemical coupling of kinesin. The difference between force-velocity curves given by force clamp and fixed trap respectively has been satisfactorily interpreted by this model. The study implies that ADP releasing and ATP hydrolysis are much less force-dependent in force clamp experiments than that in fixed trap experiments in the regime of moderate loading force, which might be a consequence of the delayed response of servo system in force clamp experiments.

  11. Lattice Boltzmann model for numerical relativity.

    Science.gov (United States)

    Ilseven, E; Mendoza, M

    2016-02-01

    In the Z4 formulation, Einstein equations are written as a set of flux conservative first-order hyperbolic equations that resemble fluid dynamics equations. Based on this formulation, we construct a lattice Boltzmann model for numerical relativity and validate it with well-established tests, also known as "apples with apples." Furthermore, we find that by increasing the relaxation time, we gain stability at the cost of losing accuracy, and by decreasing the lattice spacings while keeping a constant numerical diffusivity, the accuracy and stability of our simulations improve. Finally, in order to show the potential of our approach, a linear scaling law for parallelization with respect to number of CPU cores is demonstrated. Our model represents the first step in using lattice kinetic theory to solve gravitational problems.

  12. STOCHASTIC CHARACTERISTICS AND MODELING OF RELATIVE ...

    African Journals Online (AJOL)

    Test

    deterministic in nature, and this has been a major constraint in achieving agricultural sustainability in most developing countries.To facilitate this study, 29 years information of the observed relative humidity of Ogun basin was obtained from the Federal ...

  13. Occupancy models to study wildlife

    Science.gov (United States)

    Bailey, Larissa; Adams, Michael John

    2005-01-01

    Many wildlife studies seek to understand changes or differences in the proportion of sites occupied by a species of interest. These studies are hampered by imperfect detection of these species, which can result in some sites appearing to be unoccupied that are actually occupied. Occupancy models solve this problem and produce unbiased estimates of occupancy and related parameters. Required data (detection/non-detection information) are relatively simple and inexpensive to collect. Software is available free of charge to aid investigators in occupancy estimation.

  14. Transitions across cognitive states and death among older adults in relation to education: A multistate survival model using data from six longitudinal studies.

    Science.gov (United States)

    Robitaille, Annie; van den Hout, Ardo; Machado, Robson J M; Bennett, David A; Čukić, Iva; Deary, Ian J; Hofer, Scott M; Hoogendijk, Emiel O; Huisman, Martijn; Johansson, Boo; Koval, Andriy V; van der Noordt, Maaike; Piccinin, Andrea M; Rijnhart, Judith J M; Singh-Manoux, Archana; Skoog, Johan; Skoog, Ingmar; Starr, John; Vermunt, Lisa; Clouston, Sean; Muniz Terrera, Graciela

    2018-04-01

    This study examines the role of educational attainment, an indicator of cognitive reserve, on transitions in later life between cognitive states (normal Mini-Mental State Examination (MMSE), mild MMSE impairment, and severe MMSE impairment) and death. Analysis of six international longitudinal studies was performed using a coordinated approach. Multistate survival models were used to estimate the transition patterns via different cognitive states. Life expectancies were estimated. Across most studies, a higher level of education was associated with a lower risk of transitioning from normal MMSE to mild MMSE impairment but was not associated with other transitions. Those with higher levels of education and socioeconomic status had longer nonimpaired life expectancies. This study highlights the importance of education in later life and that early life experiences can delay later compromised cognitive health. This study also demonstrates the feasibility and benefit in conducting coordinated analysis across multiple studies to validate findings. Copyright © 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

  15. Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study

    Directory of Open Access Journals (Sweden)

    Kang Yoon-Jung

    2011-06-01

    Full Text Available Abstract Background A new lower-cost rapid-throughput human papillomavirus (HPV test (careHPV, Qiagen, Gaithersburg, USA has been shown to have high sensitivity for the detection of high grade cervical intraepithelial neoplasia. Methods We assessed the outcomes and cost-effectiveness of careHPV screening in rural China, compared to visual inspection with acetic acid, when used alone (VIA or in combination with Lugol's iodine (VIA/VILI. Using data on sexual behaviour, test accuracy, diagnostic practices and costs from studies performed in rural China, we estimated the cost-effectiveness ratio (CER and associated lifetime outcomes for once-lifetime and twice-lifetime screening strategies, and for routine screening at 5-yearly, 10-yearly and IARC-recommended intervals. The optimal age range for once-lifetime screening was also assessed. Results For all strategies, the relative ordering of test technologies in reducing cervical cancer incidence and mortality was VIA (least effective; VIA/VILI; careHPV@1.0 pg/ml and careHPV@0.5 pg/ml (most effective. For once-lifetime strategies, maximum effectiveness was achieved if screening occurred between 35-50 years. Assuming a participation rate of ~70%, once-lifetime screening at age 35 years would reduce cancer mortality by 8% (for VIA to 12% (for careHPV@0.5 over the long term, with a CER of US$557 (for VIA to $959 (for careHPV@1.0 per life year saved (LYS compared to no intervention; referenced to a 2008 GDP per capita in Shanxi Province of $2,975. Correspondingly, regular screening with an age-standardised participation rate of 62% (which has been shown to be achievable in this setting would reduce cervical cancer mortality by 19-28% (for 10-yearly screening to 43-54% (using IARC-recommended intervals, with corresponding CERs ranging from $665 (for 10-yearly VIA to $2,269 (for IARC-recommended intervals using careHPV@1.0 per LYS. Conclusions This modelled analysis suggests that primary careHPV screening

  16. Gut-related radionuclide studies

    International Nuclear Information System (INIS)

    Sullivan, M.F.

    1982-01-01

    This project is concerned with the behavior of radioactive materials that may be ingested as a consequence of a reactor accident, unavoidable occupational exposure, or after release to the environment and incorporation into the food chain. Current emphasis is directed toward evaluating hazards from ingested actinides as a function of animal age, species, nutrition, and diet, or chemicophysical state of the actinide. Recent observations indicate that the influence of chemical form on plutonium absorption observed at high mass levels does not occur at low mass concentrations. For example, at doses of 0.6 μg/kg there was no difference between absorption of the carbonate, citrate or nitrate forms of plutonium. However, at 1.5 mg/kg, the citrate was absorbed in quantities 30 times higher than the nitrate. The opposite effect occurred for neptunium GI absorption. Furthermore, it was demonstrated that materials such as citrus fruit juices and calcium, as well as drugs that affect GI function (such as aspirin and DTPA), markedly influence GI absorption of plutonium. Such studies provide evidence that diet and nutritional state should be considered in establishing safe limits for radionuclides that may be ingested

  17. Mapping Relational Operations onto Hypergraph Model

    Directory of Open Access Journals (Sweden)

    2010-10-01

    . However, the hypergraph model is non-tabular; thus, loses the simplicity of the relational model. In this study, we consider the means to convert a relational model into a hypergraph model in two layers. At the bottom layer, each relational tuple can be considered as a star graph centered where the primary key node is surrounded by non-primary key attributes. At the top layer, each tuple is a hypernode, and a relation is a set of hypernodes. We presented a reference implementation of relational operators (project, rename, select, inner join, natural join, left join, right join, outer join and Cartesian join on a hypergraph model. Using a simple example, we demonstrate that a relation and relational operators can be implemented on this hypergraph model.

  18. How Is Building Lego Models Related to Math Skills?

    OpenAIRE

    Murti, Swiya; Szucs, Denes

    2017-01-01

    Math is usually taught using a lot of words. But, is this the way the human brain learns math? We studied how math is related to memory, intelligence, and reading in 7-year-old children. We found that memory for visual information (things you can see) and spatial information (where things are located in relationship to each other) is related to math skills more than memory for words and verbal information. Interestingly, previous studies have found that building Lego models (construction play...

  19. Personality, Relationship Conflict, and Teamwork-Related Mental Models

    Science.gov (United States)

    Vîrgă, Delia; CurŞeu, Petru Lucian; Maricuţoiu, Laurenţiu; Sava, Florin A.; Macsinga, Irina; Măgurean, Silvia

    2014-01-01

    This study seeks to explore whether neuroticism, agreeableness, and conscientiousness moderate the influence of relationship conflict experienced in groups on changes in group members' evaluative cognitions related to teamwork quality (teamwork-related mental models). Data from 216 students, nested in 48 groups were analyzed using a multilevel modeling approach. Our results show that the experience of relationship conflict leads to a negative shift from the pre-task to the post-task teamwork-related mental models. Moreover, the results indicate that conscientiousness buffered the negative association between relationship conflict and the change in teamwork-related mental models. Our results did not support the hypothesized moderating effect of agreeableness and show that the detrimental effect of relationship conflict on the shift in teamwork-related mental models is accentuated for group members scoring low rather than high on neuroticism. These findings open new research venues for exploring the association between personality, coping styles and change in teamwork-related mental models. PMID:25372143

  20. Personality, relationship conflict, and teamwork-related mental models.

    Science.gov (United States)

    Vîrgă, Delia; Curşeu, Petru Lucian; CurŞeu, Petru Lucian; Maricuţoiu, Laurenţiu; Sava, Florin A; Macsinga, Irina; Măgurean, Silvia

    2014-01-01

    This study seeks to explore whether neuroticism, agreeableness, and conscientiousness moderate the influence of relationship conflict experienced in groups on changes in group members' evaluative cognitions related to teamwork quality (teamwork-related mental models). Data from 216 students, nested in 48 groups were analyzed using a multilevel modeling approach. Our results show that the experience of relationship conflict leads to a negative shift from the pre-task to the post-task teamwork-related mental models. Moreover, the results indicate that conscientiousness buffered the negative association between relationship conflict and the change in teamwork-related mental models. Our results did not support the hypothesized moderating effect of agreeableness and show that the detrimental effect of relationship conflict on the shift in teamwork-related mental models is accentuated for group members scoring low rather than high on neuroticism. These findings open new research venues for exploring the association between personality, coping styles and change in teamwork-related mental models.

  1. Assessment of Industry-Induced Urban Human Health Risks Related to Benzo[a]pyrenebased on a Multimedia Fugacity Model: Case Study of Nanjing, China.

    Science.gov (United States)

    Xu, Linyu; Song, Huimin; Wang, Yan; Yin, Hao

    2015-05-29

    Large amounts of organic pollutants emitted from industries have accumulated and caused serious human health risks, especially in urban areas with rapid industrialization. This paper focused on the carcinogen benzo[a]pyrene (BaP) from industrial effluent and gaseous emissions, and established a multi-pathway exposure model based on a Level IV multimedia fugacity model to analyze the human health risks in a city that has undergone rapid industrialization. In this study, GIS tools combined with land-use data was introduced to analyze smaller spatial scales so as to enhance the spatial resolution of the results. An uncertainty analysis using a Monte Carlo simulation was also conducted to illustrate the rationale of the probabilistic assessment mode rather than deterministic assessment. Finally, the results of the case study in Nanjing, China indicated the annual average human cancer risk induced by local industrial emissions during 2002-2008 (lowest at 1.99x10(-6) in 2008 and highest at 3.34x10(-6) in 2004), which was lower than the USEPA prescriptive level (1x10(-6)-1x10(-4)) but cannot be neglected in the long term. The study results could not only instruct the BaP health risk management but also help future health risk prediction and control.

  2. Assessment of Industry-Induced Urban Human Health Risks Related to Benzo[a]pyrene based on a Multimedia Fugacity Model: Case Study of Nanjing, China

    Directory of Open Access Journals (Sweden)

    Linyu Xu

    2015-05-01

    Full Text Available Large amounts of organic pollutants emitted from industries have accumulated and caused serious human health risks, especially in urban areas with rapid industrialization. This paper focused on the carcinogen benzo[a]pyrene (BaP from industrial effluent and gaseous emissions, and established a multi-pathway exposure model based on a Level IV multimedia fugacity model to analyze the human health risks in a city that has undergone rapid industrialization. In this study, GIS tools combined with land-use data was introduced to analyze smaller spatial scales so as to enhance the spatial resolution of the results. An uncertainty analysis using a Monte Carlo simulation was also conducted to illustrate the rationale of the probabilistic assessment mode rather than deterministic assessment. Finally, the results of the case study in Nanjing, China indicated the annual average human cancer risk induced by local industrial emissions during 2002–2008 (lowest at 1.99´10–6 in 2008 and highest at 3.34´10–6 in 2004, which was lower than the USEPA prescriptive level (1´10–6–1´10–4 but cannot be neglected in the long term. The study results could not only instruct the BaP health risk management but also help future health risk prediction and control.

  3. Risk considerations related to lung modeling

    International Nuclear Information System (INIS)

    Masse, R.; Cross, F.T.

    1989-01-01

    Improved lung models provide a more accurate assessment of dose from inhalation exposures and, therefore, more accurate dose-response relationships for risk evaluation and exposure limitation. Epidemiological data for externally irradiated persons indicate that the numbers of excess respiratory tract carcinomas differ in the upper airways, bronchi, and distal lung. Neither their histogenesis and anatomical location nor their progenitor cells are known with sufficient accuracy for accurate assessment of the microdosimetry. The nuclei of sensitive cells generally can be assumed to be distributed at random in the epithelium, beneath the mucus and tips of the beating cilia and cells. In stratified epithelia, basal cells may be considered the only cells at risk. Upper-airway tumors have been observed in both therapeutically irradiated patients and in Hiroshima-Nagasaki survivors. The current International Commission on Radiological Protection Lung-Model Task Group proposes that the upper airways and lung have a similar relative risk coefficient for cancer induction. The partition of the risk weighting factor, therefore, will be proportional to the spontaneous death rate from tumors, and 80% of the weighting factor for the respiratory tract should be attributed to the lung. For Weibel lung-model branching generations 0 to 16 and 17 to 23, the Task Group proposes an 80/20 partition of the risk, i.e., 64% and 16%, respectively, of the total risk. Regarding risk in animals, recent data in rats indicate a significantly lower effectiveness for lung-cancer induction at low doses from insoluble long-lived alpha-emitters than from Rn daughters. These findings are due, in part, to the fact that different regions of the lung are irradiated. Tumors in the lymph nodes are rare in people and animals exposed to radiation.44 references

  4. Advancing engagement methods for trials: the CORE study relational model of engagement for a stepped wedge cluster randomised controlled trial of experience-based co-design for people living with severe mental illnesses.

    Science.gov (United States)

    Richard, Lauralie; Piper, Donella; Weavell, Wayne; Callander, Rosemary; Iedema, Rick; Furler, John; Pierce, David; Godbee, Kali; Gunn, Jane; Palmer, Victoria J

    2017-04-08

    Engagement is essential in trials research but is rarely embedded across all stages of the research continuum. The development, use, effectiveness and value of engagement in trials research is poorly researched and understood, and models of engagement are rarely informed by theory. This article describes an innovative methodological approach for the development and application of a relational model of engagement in a stepped wedge designed cluster randomised controlled trial (RCT), the CORE study. The purpose of the model is to embed engagement across the continuum of the trial which will test if an experience-based co-design intervention improves psychosocial recovery for people affected by severe mental illness. The model was developed in three stages and used a structured iterative approach. A context mapping assessment of trial sites was followed by a literature review on recruitment and retention of hard-to-reach groups in complex interventions and RCTs. Relevant theoretical and philosophical underpinnings were identified by an additional review of literature to inform model development and enactment of engagement activities. Policy, organisational and service user data combined with evidence from the literature on barriers to recruitment provided contextual information. Four perspectives support the theoretical framework of the relational model of engagement and this is organised around two facets: the relational and continuous. The relational facet is underpinned by relational ethical theories and participatory action research principles. The continuous facet is supported by systems thinking and translation theories. These combine to enact an ethics of engagement and evoke knowledge mobilisation to reach the higher order goals of the model. Engagement models are invaluable for trials research, but there are opportunities to advance their theoretical development and application, particularly within stepped wedge designed studies where there may be a

  5. Model studies of the influence of O2 photodissociation parameterizations in the Schumann-Runge bands on ozone related photolysis in the upper atmosphere

    Directory of Open Access Journals (Sweden)

    Gijs A. A. Koppers

    Full Text Available A new parameterization for atmospheric transmission and O2 photodissociation in the Schumann-Runge band region has been developed and tested with a 1D radiative-photochemical model. The parameterization is based on the O2-column along the line of sight to the Sun and the local temperature. Line-by-line calculations have served as a benchmark for testing this method and several other, commonly used, parameterizations. The comparisons suggest that differences between the line-by-line calculations and currently accepted parameterizations can be reduced significantly by using the new method, particularly at large solar zenith angles. The production rate of O-atoms computed with this method shows less than 6% deviation compared to the line-by-line calculations at any altitude, all solar zenith angles and in all seasons. The largest errors are found toward the shorter wavelengths in the Schumann-Runge region at low altitudes. Transmittance is approximated to better than 4% at any altitude and/or solar zenith angle. The total O-production rate above 20 km is approximated to better than 2%. The new parameterization is easily implemented in existing photochemical models and in many cases it may simply replace the existing algorithm. The computational effort exceeds that of other parameterizations but in view of the total computation time needed for the actual calculation of the parameterized Schumann-Runge bands this should not lead to significant performance degeneration. The first 14 coefficients of the parameterization are included in this study. Both the complete sets of coefficients and a simple algorithm can be obtained by contacting the authors. A photochemical model study shows the largest effect of the parameterization method is on odd hydrogen concentrations. Subsequent interaction with an odd oxygen family causes differences in the ozone concentrations between the different parameterizations of more than 10% at selected

  6. A rat model of central venous catheter to study establishment of long-term bacterial biofilm and related acute and chronic infections.

    Directory of Open Access Journals (Sweden)

    Ashwini Chauhan

    Full Text Available Formation of resilient biofilms on medical devices colonized by pathogenic microorganisms is a major cause of health-care associated infection. While in vitro biofilm analyses led to promising anti-biofilm approaches, little is known about their translation to in vivo situations and on host contribution to the in vivo dynamics of infections on medical devices. Here we have developed an in vivo model of long-term bacterial biofilm infections in a pediatric totally implantable venous access port (TIVAP surgically placed in adult rats. Using non-invasive and quantitative bioluminescence, we studied TIVAP contamination by clinically relevant pathogens, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Staphylococcus epidermidis, and we demonstrated that TIVAP bacterial populations display typical biofilm phenotypes. In our study, we showed that immunocompetent rats were able to control the colonization and clear the bloodstream infection except for up to 30% that suffered systemic infection and death whereas none of the immunosuppressed rats survived the infection. Besides, we mimicked some clinically relevant TIVAP associated complications such as port-pocket infection and hematogenous route of colonization. Finally, by assessing an optimized antibiotic lock therapy, we established that our in vivo model enables to assess innovative therapeutic strategies against bacterial biofilm infections.

  7. Risk patterns in drug safety study using relative times by accelerated failure time models when proportional hazards assumption is questionable: an illustrative case study of cancer risk of patients on glucose-lowering therapies.

    Science.gov (United States)

    Ng, Edmond S-W; Klungel, Olaf H; Groenwold, Rolf H H; van Staa, Tjeerd-Pieter

    2015-01-01

    Observational drug safety studies may be susceptible to confounding or protopathic bias. This bias may cause a spurious relationship between drug exposure and adverse side effect when none exists and may lead to unwarranted safety alerts. The spurious relationship may manifest itself through substantially different risk levels between exposure groups at the start of follow-up when exposure is deemed too short to have any plausible biological effect of the drug. The restrictive proportional hazards assumption with its arbitrary choice of baseline hazard function renders the commonly used Cox proportional hazards model of limited use for revealing such potential bias. We demonstrate a fully parametric approach using accelerated failure time models with an illustrative safety study of glucose-lowering therapies and show that its results are comparable against other methods that allow time-varying exposure effects. Our approach includes a wide variety of models that are based on the flexible generalized gamma distribution and allows direct comparisons of estimated hazard functions following different exposure-specific distributions of survival times. This approach lends itself to two alternative metrics, namely relative times and difference in times to event, allowing physicians more ways to communicate patient's prognosis without invoking the concept of risks, which some may find hard to grasp. In our illustrative case study, substantial differences in cancer risks at drug initiation followed by a gradual reduction towards null were found. This evidence is compatible with the presence of protopathic bias, in which undiagnosed symptoms of cancer lead to switches in diabetes medication. Copyright © 2015 John Wiley & Sons, Ltd.

  8. Experimental Models of Transfusion-Related Acute Lung Injury (TRALI)

    OpenAIRE

    Gilliss, Brian M.; Looney, Mark R.

    2011-01-01

    Transfusion-related acute lung injury (TRALI) is defined clinically as acute lung injury occurring within six hours of the transfusion of any blood product. It is the leading cause of transfusion-related death in the United States, but under-recognition and diagnostic uncertainty have limited clinical research to smaller case control studies. In this review we will discuss the contribution of experimental models to the understanding of TRALI pathophysiology and potential therapeutic approache...

  9. [Study on the spatial distribution and related risks of Rhombomys opimus, based on the ecological niche modeling in Junggar Basin, Xinjiang].

    Science.gov (United States)

    Wang, Mei; Luo, Tao; Zhao, Jian; Wang, Qiguo; Li, Bo; Azha, Ti; Zhang, Yujiang; Li, Qun

    2014-09-01

    In order to understand the distribution of the host animals in Junggar Basin, this study intended to map the spatial distribution and identifying the risk of Rhombomys opimus in the framework of ecological niche theory based on the "3S" technology. Data on Rhombomys opimus was obtained through a series of field surveys. Environmental variables were achieved through data from Remote Sensing. Maxent modeling was built to map the potential distribution of Rhombomys opimus, with its risks identified. The prediction model showed ideal accuracy, with the AUC value as 0.968. Probability of Maximum Youden Index was defined as the threshold being used. The sensitivity and specificity showed as 91.4% and 63.3%, respectively. The accuracy was 73.8%, and the Kappa coefficient was 0.495. The positive predictive value was 59.7%. The negative predictive value was 92.6%. The predicted high risk area was 37 304 km2, with 6.2% in the whole area, distributed in 18 counties, including Changji Hui Autonomous Prefecture, Urumqi, Karamay and so on. The number of people under high risk would come about 120 000, scattering in the areas of 261 square kilometers. It was feasible to predict the potential distribution of Rhombomys opimus based on the ecological niche theory as well as environmental variables derived from data through remote sensing. More specific high-risk areas could be identified under this technique so as to guide the monitoring programs.

  10. Handbook of latent variable and related models

    CERN Document Server

    Lee, Sik-Yum

    2011-01-01

    This Handbook covers latent variable models, which are a flexible class of models for modeling multivariate data to explore relationships among observed and latent variables.- Covers a wide class of important models- Models and statistical methods described provide tools for analyzing a wide spectrum of complicated data- Includes illustrative examples with real data sets from business, education, medicine, public health and sociology.- Demonstrates the use of a wide variety of statistical, computational, and mathematical techniques.

  11. Model, Materialism, and Immanent Utopia in Relational Aesthetics

    DEFF Research Database (Denmark)

    Degn Johansson, Troels

    is tied up with a principle of immanence which is crucial for the understanding of Bourriaud's and many of his related artists' sense of utopia and avant-garde. Setting off from an analysis of the concept of model in RA, I would like to demonstrate the relationship between relational form, model......, and utopia, and how this surprisingly lead to an ideal yet immanent conception of art. To contextualise and exemplify my analysis, I shall draw on my collaboration-based study of art collective Superflex as well as Bourriaud's later writings on post-production and alter-modernism....

  12. A multistate additive relative survival semi-Markov model.

    Science.gov (United States)

    Gillaizeau, Florence; Dantan, Etienne; Giral, Magali; Foucher, Yohann

    2017-08-01

    Medical researchers are often interested to investigate the relationship between explicative variables and times-to-events such as disease progression or death. Such multiple times-to-events can be studied using multistate models. For chronic diseases, it may be relevant to consider semi-Markov multistate models because the transition intensities between two clinical states more likely depend on the time already spent in the current state than on the chronological time. When the cause of death for a patient is unavailable or not totally attributable to the disease, it is not possible to specifically study the associations with the excess mortality related to the disease. Relative survival analysis allows an estimate of the net survival in the hypothetical situation where the disease would be the only possible cause of death. In this paper, we propose a semi-Markov additive relative survival (SMRS) model that combines the multistate and the relative survival approaches. The usefulness of the SMRS model is illustrated by two applications with data from a French cohort of kidney transplant recipients. Using simulated data, we also highlight the effectiveness of the SMRS model: the results tend to those obtained if the different causes of death are known.

  13. Fault-related-folding structures and reflection seismic sections. Study by seismic modeling and balanced cross section; Danso ga kaizaisuru shukyoku kozo no keitai to jishin tansa danmen. 2. Seismic modeling oyobi balanced cross section ni yoru study

    Energy Technology Data Exchange (ETDEWEB)

    Tamagawa, T.; Matsuoka, T. [Japan Petroleum Exploration Corp., Tokyo (Japan); Tsukui, R. [Japan National Oil Corp., Tokyo (Japan). Technology Research Center

    1997-05-27

    It occasionally happens that there exists a part where reflection near the thrust is not clearly observed in a thrust zone seismic survey cross section. For the effective interpretation of such an occurrence, the use of geological structures as well as the reflected pattern is effective. When the velocity structures for a fold structure having a listric fault caused anticline (unidirectionally inclined with a backlimb, without a forelimb) and for a fault propagation fold are involved, a wrong interpretation may be made since they look alike in reflection wave pattern despite their difference in geological structure. In the concept of balanced cross section, a check is performed, when the stratum after deformation is recovered to the time of deposition, as to whether the geologic stratum area is conserved without excess or shortage. An excess or shortage occurs if there is an error in the model, and this shows that the fault surface or fold structure is not correctly reflected. Positive application of geological knowledge is required in the processing and interpreting of data from a seismic survey. 6 refs., 6 figs.

  14. Pain-Related Brain Activity Evoked by Active and Dynamic Arm Movement: Delayed-Onset Muscle Soreness as a Promising Model for Studying Movement-Related Pain in Humans.

    Science.gov (United States)

    Matsuda, Yoichi; Kan, Shigeyuki; Uematsu, Hironobu; Shibata, Masahiko; Fujino, Yuji

    2015-08-01

    To demonstrate delayed-onset muscle soreness (DOMS) is a suitable model for the study of movement-evoked pain, we attempted to identify brain regions specifically involved in pain evoked by active and dynamic movement under DOMS condition. Twelve healthy volunteers DOMS was induced in the left upper-arm flexor muscles by an eccentric elbow contraction exercise. Movement-evoked pain in the affected muscles was evaluated just before (day 0) and after (days 1-7 and 30) the exercise using a visual analog scale. Subjects underwent functional magnetic resonance imaging scans while performing repeated elbow flexion on day 2 (DOMS condition) and day 30 (painless condition). We compared brain activity between the DOMS and painless conditions. Movement-evoked pain reached peak intensity on day 2 and disappeared by day 30 in all subjects. No subject felt pain at rest on either of these days. Contralateral primary motor cortex (M1), parietal operculum and bilateral presupplementary motor area (pre-SMA) showed greater activity during active and dynamic arm movement with DOMS than during the same movement without pain. There was no difference in activation of brain regions known collectively as the "pain matrix," except for the parietal operculum, between the two conditions. Active and dynamic movement with pain selectively evoked activation of M1, pre-SMA, and parietal operculum, as assessed using DOMS. Our results demonstrate that DOMS is a promising experimental model for the study of movement-evoked pain in humans. 2015 The Authors Pain Medicine published by Wiley Periodicals, Inc. on behalf of American Academy of Pain Medicine.

  15. Maneuver Estimation Model for Relative Orbit Determination

    National Research Council Canada - National Science Library

    Storch, Tara R

    2005-01-01

    While the use of relative orbit determination has reduced the difficulties inherent in tracking geosynchronous satellites that are in close proximity, the problem is often compounded by stationkeeping...

  16. Rodent models for studying empathy.

    Science.gov (United States)

    Keum, Sehoon; Shin, Hee-Sup

    2016-11-01

    Empathy is the important capacity to recognize and share emotions with others. Recent evidence shows that rodents possess a remarkable affective sensitivity to the emotional state of others and that primitive forms of empathy exist in social lives of rodents. However, due to the ambiguous definitional boundaries between empathy, emotional contagion and other related terms, distinct components of empathic behaviors in rodents need to be clarified. Hence, we review recent experimental studies demonstrating that rodents are able to share emotions with others. Specifically, we highlight several behavioral models that examine different aspects of rodent empathic behaviors in response to the various distress of conspecifics. Experimental approaches using rodent behavioral models will help elucidate the neural circuitry of empathy and its neurochemical association. Integrating these findings with corresponding experiments in humans will ultimately provide novel insights into therapeutic interventions for mental disorders associated with empathy. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Multi-disciplinary data organization and visualization models for clinical and pre-clinical studies: A case study in the application of proton beam radiosurgery for treating spinal cord injury related pain

    Science.gov (United States)

    Verma, Sneha K.; Liu, Brent J.

    2016-03-01

    An increasing adoption of electronic medical records has made information more accessible to clinicians and researchers through dedicated systems such as HIS, RIS and PACS. The speed and the amount at which information are generated in a multi-institutional clinical study make the problem complicated compared to day-to-day hospital workflow. Often, increased access to the information does not translate into the efficient use of that information. Therefore, it becomes crucial to establish models which can be used to organize and visualize multi-disciplinary data. Good visualization in turn makes it easy for clinical decision-makers to reach a conclusion within a small span of time. In a clinical study involving multi-disciplinary data and multiple user groups who need access to the same data and presentation states based on the stage of the clinical trial or the task are crucial within the workflow. Therefore, in order to demonstrate the conceptual system design and system workflow, we will be presenting a clinical trial based on application of proton beam for radiosurgery which will utilize our proposed system. For demonstrating user role and visualization design purposes, we will be focusing on three different user groups which are researchers involved in patient enrollment and recruitment, clinicians involved in treatment and imaging review and lastly the principle investigators involved in monitoring progress of clinical study. Also datasets for each phase of the clinical study including preclinical and clinical data as it related to subject enrollment, subject recruitment (classifier), treatment (DICOM), imaging, and pathological analysis (protein staining) of outcomes.

  18. Studies on DANESS Code Modeling

    International Nuclear Information System (INIS)

    Jeong, Chang Joon

    2009-09-01

    The DANESS code modeling study has been performed. DANESS code is widely used in a dynamic fuel cycle analysis. Korea Atomic Energy Research Institute (KAERI) has used the DANESS code for the Korean national nuclear fuel cycle scenario analysis. In this report, the important models such as Energy-demand scenario model, New Reactor Capacity Decision Model, Reactor and Fuel Cycle Facility History Model, and Fuel Cycle Model are investigated. And, some models in the interface module are refined and inserted for Korean nuclear fuel cycle model. Some application studies have also been performed for GNEP cases and for US fast reactor scenarios with various conversion ratios

  19. Early Port-Related Structure Studies

    Science.gov (United States)

    McCarthy, Michael

    2013-12-01

    This paper examines three of Australia's earliest port-related structure studies. Excavations conducted in 1984 and 1994 in vastly different circumstances, with markedly different oceanographic conditions, progressing through quite different substrates, were joined with 1993-1994 overview of all the port structures along the coast of Western Australia. Providing a better appreciation of submerged port-related structure studies as a bona fide part of maritime archaeology, these three studies and have ramifications for future work both in Australia and overseas.

  20. Experimental models of transfusion-related acute lung injury.

    Science.gov (United States)

    Gilliss, Brian M; Looney, Mark R

    2011-01-01

    Transfusion-related acute lung injury (TRALI) is defined clinically as acute lung injury occurring within six hours of the transfusion of any blood product. It is the leading cause of transfusion-related death in the United States, but under-recognition and diagnostic uncertainty have limited clinical research to smaller case control studies. In this review we discuss the contribution of experimental models to the understanding of TRALI pathophysiology and potential therapeutic approaches. Experimental models suggest that TRALI occurs when a host, with a primed immune system, is exposed to an activating agent such as anti-leukocyte antibody or a biologic response modifier such as lysophosphatidylcholines. Recent work has suggested a critical role for platelets in antibody-based experimental models and identified potential therapeutic strategies for TRALI. Copyright © 2011 Elsevier Inc. All rights reserved.

  1. Experimental Models of Transfusion-Related Acute Lung Injury (TRALI)

    Science.gov (United States)

    Gilliss, Brian M.; Looney, Mark R.

    2010-01-01

    Transfusion-related acute lung injury (TRALI) is defined clinically as acute lung injury occurring within six hours of the transfusion of any blood product. It is the leading cause of transfusion-related death in the United States, but under-recognition and diagnostic uncertainty have limited clinical research to smaller case control studies. In this review we will discuss the contribution of experimental models to the understanding of TRALI pathophysiology and potential therapeutic approaches. Experimental models suggest that TRALI occurs when a host, with a primed immune system, is exposed to an activating agent such as anti-leukocyte antibody or a biologic response modifier such as lysophosphatidylcholines. Recent work has suggested a critical role for platelets in antibody-based experimental models and identified potential therapeutic strategies for TRALI. PMID:21134622

  2. RBE and related modeling in carbon-ion therapy

    Science.gov (United States)

    Karger, Christian P.; Peschke, Peter

    2018-01-01

    Carbon ion therapy is a promising evolving modality in radiotherapy to treat tumors that are radioresistant against photon treatments. As carbon ions are more effective in normal and tumor tissue, the relative biological effectiveness (RBE) has to be calculated by bio-mathematical models and has to be considered in the dose prescription. This review (i) introduces the concept of the RBE and its most important determinants, (ii) describes the physical and biological causes of the increased RBE for carbon ions, (iii) summarizes available RBE measurements in vitro and in vivo, and (iv) describes the concepts of the clinically applied RBE models (mixed beam model, local effect model, and microdosimetric-kinetic model), and (v) the way they are introduced into clinical application as well as (vi) their status of experimental and clinical validation, and finally (vii) summarizes the current status of the use of the RBE concept in carbon ion therapy and points out clinically relevant conclusions as well as open questions. The RBE concept has proven to be a valuable concept for dose prescription in carbon ion radiotherapy, however, different centers use different RBE models and therefore care has to be taken when transferring results from one center to another. Experimental studies significantly improve the understanding of the dependencies and limitations of RBE models in clinical application. For the future, further studies investigating quantitatively the differential effects between normal tissues and tumors are needed accompanied by clinical studies on effectiveness and toxicity.

  3. Modeling vulnerability of groundwater to pollution under future scenarios of climate change and biofuels-related land use change: a case study in North Dakota, USA.

    Science.gov (United States)

    Li, Ruopu; Merchant, James W

    2013-03-01

    Modeling groundwater vulnerability to pollution is critical for implementing programs to protect groundwater quality. Most groundwater vulnerability modeling has been based on current hydrogeology and land use conditions. However, groundwater vulnerability is strongly dependent on factors such as depth-to-water, recharge and land use conditions that may change in response to future changes in climate and/or socio-economic conditions. In this research, a modeling framework, which employs three sets of models linked within a geographic information system (GIS) environment, was used to evaluate groundwater pollution risks under future climate and land use changes in North Dakota. The results showed that areas with high vulnerability will expand northward and/or northwestward in Eastern North Dakota under different scenarios. GIS-based models that account for future changes in climate and land use can help decision-makers identify potential future threats to groundwater quality and take early steps to protect this critical resource. Copyright © 2013 Elsevier B.V. All rights reserved.

  4. Scoping study of salt domes, basalts and crystalline rock as related to long term risk modeling for deep geologic disposal of nuclear waste

    International Nuclear Information System (INIS)

    1978-11-01

    Purpose is to provide a preliminary geotechnical data base sufficient to initiate the development of Long-Term Risk Models for salt domes, basalt, and crystalline rock. Geology, hydrology, specific sites, and potential release pathways are considered for each type. A summary table of site suitability characteristics is presented

  5. Animal Models of Hemophilia and Related Bleeding Disorders

    Science.gov (United States)

    Lozier, Jay N.; Nichols, Timothy C.

    2013-01-01

    Animal models of hemophilia and related diseases are important for development of novel treatments and to understand the pathophysiology of bleeding disorders in humans. Testing in animals with the equivalent human disorder provides informed estimates of doses and measures of efficacy, which aids in design of human trials. Many models of hemophilia A, hemophilia B, and von Willebrand disease have been developed from animals with spontaneous mutations (hemophilia A dogs, rats, sheep; hemophilia B dogs; and von Willebrand disease pigs and dogs), or by targeted gene disruption in mice to create hemophilia A, B, or VWD models. Animal models have been used to generate new insights into the pathophysiology of each bleeding disorder and also to perform pre-clinical assessments of standard protein replacement therapies as well as novel gene transfer technology. Both the differences between species and differences in underlying causative mutations must be considered in choosing the best animal for a specific scientific study PMID:23956467

  6. Precision-cut mouse liver slices as an ex vivo model to study the mechanism of inflammatory stress-related idiosyncratic drug-induced liver injury

    NARCIS (Netherlands)

    Hadi, Mackenzie; Chen, Y.; Starokozhko, Viktoriia; Merema, Maja; Groothuis, Genoveva

    2012-01-01

    Idiosyncratic drug reactions (IDRs) can be defined as adverse drug reactions that occur in a small minority of the patients taking clinically-relevant doses and do not involve the known pharmacological effects of the drug. IDR related to hepatotoxicity or idiosyncratic drug-induced liver injury

  7. Relational Model Conflicts in Knowledge Sharing Behavior

    NARCIS (Netherlands)

    P.J. van Baalen (Peter); J. van Dalen (Jan); J. van Malsen (Jorina)

    2013-01-01

    textabstractThe distributed nature of organizational knowledge makes that knowledge sharing an important factor for unlocking its potential value. In practice, however, people may have different motivations for not sharing knowledge with colleagues, which in part may be due to the relational

  8. An Exploratory study of compliance with dietary recommendations among college students majoring in health-related disciplines: application of the transtheoretical model

    OpenAIRE

    McArthur, Laura H.; Pawlak, Roman

    2011-01-01

    Compliance with food group and nutrient recommendations, and self-efficacy, stage of change, perceived barriers and benefits for healthy eating were assessed among a convenience sample of college students majoring in health-related disciplines. Dietary and psychosocial data were collected using three-day food records and scales, respectively. Means (SD), frequencies, and percents were calculated on all data, and logistic regressions were used to determine whether any of the psychosocial corre...

  9. Battlescale Forecast Model Sensitivity Study

    National Research Council Canada - National Science Library

    Sauter, Barbara

    2003-01-01

    .... Changes to the surface observations used in the Battlescale Forecast Model initialization led to no significant changes in the resulting forecast values of temperature, relative humidity, wind speed, or wind direction...

  10. NURE uranium deposit model studies

    International Nuclear Information System (INIS)

    Crew, M.E.

    1981-01-01

    The National Uranium Resource Evaluation (NURE) Program has sponsored uranium deposit model studies by Bendix Field Engineering Corporation (Bendix), the US Geological Survey (USGS), and numerous subcontractors. This paper deals only with models from the following six reports prepared by Samuel S. Adams and Associates: GJBX-1(81) - Geology and Recognition Criteria for Roll-Type Uranium Deposits in Continental Sandstones; GJBX-2(81) - Geology and Recognition Criteria for Uraniferous Humate Deposits, Grants Uranium Region, New Mexico; GJBX-3(81) - Geology and Recognition Criteria for Uranium Deposits of the Quartz-Pebble Conglomerate Type; GJBX-4(81) - Geology and Recognition Criteria for Sandstone Uranium Deposits in Mixed Fluvial-Shallow Marine Sedimentary Sequences, South Texas; GJBX-5(81) - Geology and Recognition Criteria for Veinlike Uranium Deposits of the Lower to Middle Proterozoic Unconformity and Strata-Related Types; GJBX-6(81) - Geology and Recognition Criteria for Sandstone Uranium Deposits of the Salt Wash Type, Colorado Plateau Province. A unique feature of these models is the development of recognition criteria in a systematic fashion, with a method for quantifying the various items. The recognition-criteria networks are used in this paper to illustrate the various types of deposits

  11. Recovery of immune competence following sublethal X irradiation of young and old mice: a model for studying age-related loss of immunologic homeostasis

    International Nuclear Information System (INIS)

    Peterson, W.J.; Perkins, E.H.; Makinodan, T.

    1982-01-01

    Age-related alteration in lymphohematopoietic homeostasis was assessed kinetically by determining immunologic and stem-cell regenerating capacities of young (5-7 months), middle-aged (13 months), and old (23-24 months) C3H and C57BL/6 mice following their exposure to 500 R. Immunologic activities were based on the ability of spleen cells to respond to sheep erythrocytes, phytohemagglutinin, and bacterial lipopolysaccharide. Stem-cell activity was based on the ability of splenic and bone marrow cells to form colonies in vivo. Reflective of age-related homeostatic imbalance was alteration in the (a) time of recovery, (b) rate of regeneration, and (c) capacity of the regenerating system to overshoot the preirradition steady-state level. Most of the immunologic parameters showed a delay in the time of recovery in old mice. In contrast, the time of recovery of stem cells in old mice was equal to or faster than that in young mice. Furthermore, the magnitude of regeneration of stem cells was greater in old than young mice. These results suggest that recovery of immunologic activities in old mice is delayed partly because of the inability of their stem cells to rapidly generate immunocompetent progenies

  12. Modeling patterns in count data using loglinear and related models

    International Nuclear Information System (INIS)

    Atwood, C.L.

    1995-12-01

    This report explains the use of loglinear and logit models, for analyzing Poisson and binomial counts in the presence of explanatory variables. The explanatory variables may be unordered categorical variables or numerical variables, or both. The report shows how to construct models to fit data, and how to test whether a model is too simple or too complex. The appropriateness of the methods with small data sets is discussed. Several example analyses, using the SAS computer package, illustrate the methods

  13. Study of inhaled radio-active pollutants: 1. Current data; II. Pathology; III. Validity of animal model. Dose-effect relations

    International Nuclear Information System (INIS)

    Lafuma, J.; Masse, R.; Metivier, H.; Nolibe, D.; Fritsch, P.; Nenot, J.C.; Morin, M.

    1974-01-01

    An attempt has been made to develop an animal for human industrial exposure to airradiation. That will give results applicable to man both qualitatively and quantitavely. Using over 2000 animals. The following studies were made. Radon, rat and occupationally exposed man; 239 plutonium oxide, rat and monkey; 12 different α and emitters, rat with different exposure media (aerosols particles) and exposure shcedules (acute chronic). Scrupulous pathological, microscopic, autoradiographic and ultrastructural analysis of animals followed their deaths. Acute changes are characterized by alveolaroedema, capillary and arteriolar thrombisus, and desquamation of type 1 pneumatocytes. There is interstitial pneumonia, hyaline membrane formation, and extensive bronchiolar and alveolar metaplasia. In a study of long-term effects a wide variety of both benign and malignant tumours was discovered. There are variations in species lateney and radiation sensitivity. The pathological changes, found in these studies are qualitatively very similar to changes found in man [fr

  14. The Need for Integrative Communication within a Multicultural Communication Model: A Case Study of Public Relations Functions and Leadership in Community Development.

    Science.gov (United States)

    Neff, Bonita Dostal; And Others

    A case study analyzed a special event, AmeriFlora '92, held from April 1992 to October 1992 in Columbus, Ohio. AmeriFlora '92 was established as a temporary organization covering nearly 8 years of planning, operations, and dismantling. The lack of attendance and the resulting financial impact inspired a major effort to examine the role of public…

  15. Transitions across cognitive states and death among older adults in relation to education : A multistate survival model using data from six longitudinal studies

    NARCIS (Netherlands)

    Robitaille, Annie; van den Hout, Ardo; Machado, Robson J M; Bennett, David A; Čukić, Iva; Deary, Ian J; Hofer, Scott M; Hoogendijk, Emiel O; Huisman, Martijn; Johansson, Boo; Koval, Andriy V; van der Noordt, Maaike; Piccinin, Andrea M; Rijnhart, Judith J M; Singh-Manoux, Archana; Skoog, Johan; Skoog, Ingmar; Starr, John; Vermunt, Lisa; Clouston, Sean; Muniz Terrera, Graciela

    2018-01-01

    INTRODUCTION: This study examines the role of educational attainment, an indicator of cognitive reserve, on transitions in later life between cognitive states (normal Mini-Mental State Examination (MMSE), mild MMSE impairment, and severe MMSE impairment) and death. METHODS: Analysis of six

  16. Do objective neighbourhood characteristics relate to residents' preferences for certain sports locations? A cross-sectional study using a discrete choice modelling approach

    NARCIS (Netherlands)

    Deelen, Ineke; Jansen, Marijke; Dogterom, Nico J.; Kamphuis, Carlijn B.M.; Ettema, Dick

    2017-01-01

    Background: The number of sports facilities, sports clubs, or city parks in a residential neighbourhood may affect the likelihood that people participate in sports and their preferences for a certain sports location. This study aimed to assess whether objective physical and socio-spatial

  17. Col6a1 Null Mice as a Model to Study Skin Phenotypes in Patients with Collagen VI Related Myopathies: Expression of Classical and Novel Collagen VI Variants during Wound Healing

    Science.gov (United States)

    Lettmann, Sandra; Bloch, Wilhelm; Maaß, Tobias; Niehoff, Anja; Schulz, Jan-Niklas; Eckes, Beate; Eming, Sabine A.; Bonaldo, Paolo; Paulsson, Mats; Wagener, Raimund

    2014-01-01

    Patients suffering from collagen VI related myopathies caused by mutations in COL6A1, COL6A2 and COL6A3 often also display skin abnormalities, like formation of keloids or “cigarette paper” scars, dry skin, striae rubrae and keratosis pilaris (follicular keratosis). Here we evaluated if Col6a1 null mice, an established animal model for the muscle changes in collagen VI related myopathies, are also suitable for the study of mechanisms leading to the skin pathology. We performed a comprehensive study of the expression of all six collagen VI chains in unwounded and challenged skin of wild type and Col6a1 null mice. Expression of collagen VI chains is regulated in both skin wounds and bleomycin-induced fibrosis and the collagen VI α3 chain is proteolytically processed in both wild type and Col6a1 null mice. Interestingly, we detected a decreased tensile strength of the skin and an altered collagen fibril and basement membrane architecture in Col6a1 null mice, the latter being features that are also found in collagen VI myopathy patients. Although Col6a1 null mice do not display an overt wound healing defect, these mice are a relevant animal model to study the skin pathology in collagen VI related disease. PMID:25158062

  18. Col6a1 null mice as a model to study skin phenotypes in patients with collagen VI related myopathies: expression of classical and novel collagen VI variants during wound healing.

    Directory of Open Access Journals (Sweden)

    Sandra Lettmann

    Full Text Available Patients suffering from collagen VI related myopathies caused by mutations in COL6A1, COL6A2 and COL6A3 often also display skin abnormalities, like formation of keloids or "cigarette paper" scars, dry skin, striae rubrae and keratosis pilaris (follicular keratosis. Here we evaluated if Col6a1 null mice, an established animal model for the muscle changes in collagen VI related myopathies, are also suitable for the study of mechanisms leading to the skin pathology. We performed a comprehensive study of the expression of all six collagen VI chains in unwounded and challenged skin of wild type and Col6a1 null mice. Expression of collagen VI chains is regulated in both skin wounds and bleomycin-induced fibrosis and the collagen VI α3 chain is proteolytically processed in both wild type and Col6a1 null mice. Interestingly, we detected a decreased tensile strength of the skin and an altered collagen fibril and basement membrane architecture in Col6a1 null mice, the latter being features that are also found in collagen VI myopathy patients. Although Col6a1 null mice do not display an overt wound healing defect, these mice are a relevant animal model to study the skin pathology in collagen VI related disease.

  19. Model quality and safety studies

    DEFF Research Database (Denmark)

    Petersen, K.E.

    1997-01-01

    evaluation group (MEG) is a European initiative on evaluation of technical models used within the major industrial hazard area and is supported by the EC DGXII, Directorate-General for Science, Research and Development. Closely related to MEG is REDIPHEM, which is the acronym of a research project supported...... by the EC Environment Research Programme focusing on assessment of the quality of experimental data and models for dense gas dispersion created within the EC funded research programmes. Technical models are used in a number of areas of industrial hazards assessment. It is becoming more and more apparent...... of ensuring that model development is of a standard that is commensurate with the importance of model use. The aim of MEG is to improve the culture in which models are developed and used and so ensure that technical models used in all aspects of major hazard evaluation are up to date with technical...

  20. The semiotics of control and modeling relations in complex systems.

    Science.gov (United States)

    Joslyn, C

    2001-01-01

    We provide a conceptual analysis of ideas and principles from the systems theory discourse which underlie Pattee's semantic or semiotic closure, which is itself foundational for a school of theoretical biology derived from systems theory and cybernetics, and is now being related to biological semiotics and explicated in the relational biological school of Rashevsky and Rosen. Atomic control systems and models are described as the canonical forms of semiotic organization, sharing measurement relations, but differing topologically in that control systems are circularly and models linearly related to their environments. Computation in control systems is introduced, motivating hierarchical decomposition, hybrid modeling and control systems, and anticipatory or model-based control. The semiotic relations in complex control systems are described in terms of relational constraints, and rules and laws are distinguished as contingent and necessary functional entailments, respectively. Finally, selection as a meta-level of constraint is introduced as the necessary condition for semantic relations in control systems and models.

  1. An Exploratory study of compliance with dietary recommendations among college students majoring in health-related disciplines: application of the transtheoretical model.

    Science.gov (United States)

    McArthur, Laura H; Pawlak, Roman

    2011-12-01

    Compliance with food group and nutrient recommendations, and self-efficacy, stage of change, perceived barriers and benefits for healthy eating were assessed among a convenience sample of college students majoring in health-related disciplines. Dietary and psychosocial data were collected using three-day food records and scales, respectively. Means (SD), frequencies, and percents were calculated on all data, and logistic regressions were used to determine whether any of the psychosocial correlates predicted the stage of change for healthy eating. Noncompliance with food group recommendations ranged from 53% for the meat/meat alternates group to 93% for the vegetables/juice group, whereas noncompliance with nutrient recommendations ranged from 26% for cholesterol to 99% for potassium. A majority of students (57%) self-classified in the preaction and 40% in the action stages of change for eating healthy. The students' self-efficacy to eat healthy was highest in positive/social situations and lowest when experiencing emotional upset. The most important perceived barrier to healthy eating was that friends/roommates do not like to eat healthy foods, and the most important perceived benefit was that eating healthy foods provides the body with adequate nutrients. The difficult/inconvenient self-efficacy subscale predicted the stage of change for healthy eating. These students would benefit from interactive learning opportunities that teach how to purchase and prepare more whole grain foods, fruits, and vegetables, enhance their self-efficacy for making healthy food choices when experiencing negative emotions, and overcome perceived barriers to healthy eating.

  2. Applying the social relations model to self and peer evaluations

    NARCIS (Netherlands)

    Greguras, G.J.; Robie, C.; Born, M.Ph.

    2001-01-01

    Peer evaluations of performance increasingly are being used to make organizational decisions and to provide individuals with performance related feedback. Using Kenny's social relations model (SRM), data from 14 teams of undergraduate students who completed performance ratings of themselves and

  3. Women's experiences of infertility - towards a relational model of care.

    Science.gov (United States)

    Cunningham, Nicola; Cunningham, Tom

    2013-12-01

    To consider the effectiveness of current models of patient-centred infertility care. Patient centredness is defined as one of six key dimensions of quality of care. In the field of infertility, a new interaction model of patient-centred infertility care is proposed. Despite positive moves, this model reveals shortcomings in knowledge about the lived experience of infertility and lacks the shift in attitudes and approach that effective patient-centred care requires. The study has a qualitative research design. Nine women living with and through infertility participated in online life-story interviews. Data were analysed using a layered strategy influenced by the voice-centred relational method, emphasising narrative content, form and function. Women reveal a complex experience. Three key themes were found: Approaching the clinic narratives are infused with personal expectations while deeply reflective of cultural expectations and social norms. Relatedness recognises women's experiences cannot be neatly separated into distinct domains. Liminality and infertility describes women's experiences lost in transition through and beyond infertility treatment. The current model of patient-centred infertility care requires further development. Women in this study found themselves lost in transition and irrespective of treatment failure or success. Conceptual development must embrace a relational understanding of patient's experience to ensure that patient-centred infertility care is realistic and relevant to patients, clinical staff and the system as a whole. Psychosocial skills are recognised as core competences for fertility nurses. A relational conceptualisation of patient's experiences, living with and through infertility, provides further information for the development of staff and enhanced knowledge and practice skills. © 2013 John Wiley & Sons Ltd.

  4. Modeling Approaches and Systems Related to Structured Modeling.

    Science.gov (United States)

    1987-02-01

    Lasdon 򒾂> and Maturana 򒾃> for surveys of several modern systems. A -6- N NN- %0 CAMPS (Lucas and Mitra 򒾁>) -- Computer Assisted Mathe- %l...583-589. MATURANA , S. 򒾃>. "Comparative Analysis of Mathematical Modeling Systems," informal note, Graduate School of Manage- ment, UCLA, February

  5. Experimental study of relative, turbulent diffusion

    DEFF Research Database (Denmark)

    Mann, J.; Ott, Søren; Andersen, J.S.

    1999-01-01

    The purpose is to study relative turbulent diffusion under controlled, reproducible conditions in the laboratory in order to estimate the constant C in Richardson-Obukhov's law. We get C #approx# 0.4 -- 0.6. We furthermore measure the distance-neighbourfunction, which is the probability density...... system with two computers each equipped with a frame grabber card. In the search for the best experimentalmethods we have revised the concept of local homogeneity and derived a law for the velocity--acceleration structure function. A second by-product of this effort is a relatively simple derivation...

  6. Negotiation as a Model for Teaching Public Relations Professionalism.

    Science.gov (United States)

    Saunders, Martha Dunagin; Perrigo, Eileen

    1998-01-01

    Shows that negotiation provides an effective model for teaching public relations professionalism. Describes how two professors in a public relations class used a negotiation model to teach students to simultaneously balance the two components of professionalism: ethical considerations and pragmatic, problem-solving measures. (SR)

  7. Longitudinal models in the behavioral and related sciences

    NARCIS (Netherlands)

    Montfort, van K.; Satorra, A.; Oud, H.

    2007-01-01

    Longitudinal Models in the Behavioral and Related Sciences opens with the latest theoretical developments. In particular, the book addresses situations that arise due to the categorical nature of the data, issues related to state space modeling, and potential problems that may arise from network

  8. Integrating Health Belief Model and Technology Acceptance Model: An Investigation of Health-Related Internet Use

    Science.gov (United States)

    2015-01-01

    Background Today, people use the Internet to satisfy health-related information and communication needs. In Malaysia, Internet use for health management has become increasingly significant due to the increase in the incidence of chronic diseases, in particular among urban women and their desire to stay healthy. Past studies adopted the Technology Acceptance Model (TAM) and Health Belief Model (HBM) independently to explain Internet use for health-related purposes. Although both the TAM and HBM have their own merits, independently they lack the ability to explain the cognition and the related mechanism in which individuals use the Internet for health purposes. Objective This study aimed to examine the influence of perceived health risk and health consciousness on health-related Internet use based on the HBM. Drawing on the TAM, it also tested the mediating effects of perceived usefulness of the Internet for health information and attitude toward Internet use for health purposes for the relationship between health-related factors, namely perceived health risk and health consciousness on health-related Internet use. Methods Data obtained for the current study were collected using purposive sampling; the sample consisted of women in Malaysia who had Internet access. The partial least squares structural equation modeling method was used to test the research hypotheses developed. Results Perceived health risk (β=.135, t 1999=2.676) and health consciousness (β=.447, t 1999=9.168) had a positive influence on health-related Internet use. Moreover, perceived usefulness of the Internet and attitude toward Internet use for health-related purposes partially mediated the influence of health consciousness on health-related Internet use (β=.025, t 1999=3.234), whereas the effect of perceived health risk on health-related Internet use was fully mediated by perceived usefulness of the Internet and attitude (β=.029, t 1999=3.609). These results suggest the central role of

  9. A dynamic study of correlation between the MR diffusion weighted imaging findings and the expression of proliferation-related and metastasis-related genes in rabbit models of liver VX2 tumor before and after chemoembolization

    International Nuclear Information System (INIS)

    Yuan Youhong; Liu Jianbin; Xiao Enhua; He Zhong; Ma Cong; Xiang Jun; Jin Ke; Chen Wenjian; Xiao Jiehua

    2007-01-01

    Objective: To investigate the correlation between the apparent diffusion coefficient (ADC) values and the expression of proliferating cell nuclear antigen (PCNA), Bax, non-metastasis 23(nm23) and E-cadherin (E-cad) genes in rabbit models of liver VX 2 tumor before and after chemoembolization. Methods: Forty rabbit models of liver VX 2 tumor were divided into four groups with 10 rabbits in each group. The first group was the control group which didn't undergo chemoembolization. The second, third and fourth groups underwent chemoembolization, and diffusion weighted imaging (DWI) was performed at 16 h, 32 h and 48 h after chemoembolization respectively. The pathological and immunohistological examinations were carried out right after DWI. The sampling areas included the normal liver parenchyma around the tumor, the outer- layer area, the peripheral area, and the central area. The expression indices of PCNA, Bax, nm23, E-cad in all the samples were recorded and their correlation with corresponding ADC value were analyzed. Results: (1) PCNA expression indices in the outer layer area, the peripheral area and central area of VX 2 tumors(65.1%, 74.7%, and 59.0% respectively) were higher than that in the area of normal parenchyma around tumor (8.3%) (X 2 =19.08, P 2 tumors (nm 23: 1.7%, 0.4% , and 6.2% respectively; Bax: 2. 0%, 1.2% , and 2. 2% respectively; E-cad:6.2%, 2.0%, and 1.6% respectively) were lower than that in the area of normal parenchyma around tumor (nm23 16.5%; Bax 40.0%; E-cad 78.0%. χ 2 =12.86, 20.17, and 22.20 respectively; P 2 tumor periphery were 83.0%, 92.6% and 85.7% in 16 h group, 32 h group and 48 h group respectively after chemoembolization and those of nm23 expression indices were 2.3%, 7.4%, 4.2% and those of Bax expression index were 0.8%, 0.5%, 0.9% and those of E-cad expression indices were 2.8%, 1.0%, 1.1%. The PCNA and nm23 expression in the area of VX 2 tumor periphery increased at the beginning and then decreased (χ 2 =14.37, 8.94; P 2

  10. Evaluating the relative effectiveness of high-intensity and low-intensity models of behaviour change communication interventions for abortion care-seeking in Bihar and Jharkhand, India: a cross-sectional study.

    Science.gov (United States)

    Banerjee, Sushanta K; Andersen, Kathryn; Pearson, Erin; Warvadekar, Janardan; Khan, Danish U; Batra, Sangeeta

    2017-02-24

    This study aimed to compare the effectiveness of a high-intensity model (HIM) and a low-intensity model (LIM) of behaviour change communication interventions in Bihar and Jharkhand states of India designed to improve women's knowledge and usage of safe abortion services, as well as the dose effect of intervention exposure. We conducted two cross-sectional household surveys among married women aged 15-49 years in intervention and comparison districts. Difference-in-difference models were used to assess the efficacy of the intervention, adjusting for sociodemographic characteristics. Although both intervention types improved abortion knowledge, the HIM intervention was more effective in improving comprehensive knowledge about abortion. In particular, there were improvements in knowledge on legality of abortion (AOR=2.2; 95% CI 1.6 to 2.9) and nearby sources of safe abortion care (AOR=1.7; 95% CI 1.2 to 1.3). Higher level of exposure to abortion-related messages was related to more accurate knowledge about abortion within both intervention groups. Evidence was mixed on changes in abortion care-seeking behaviour. More work is needed to ensure that women seek safe abortion services in lieu of informal services that may be more likely to lead to postabortion complications. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  11. Relating backprojection images to kinematics and dynamic source models

    Science.gov (United States)

    Yin, J.; Denolle, M.

    2017-12-01

    Backprojection (BP) of teleseismic P waves is a method widely used to study the evolution of earthquake radiation and is particularly effective for large earthquakes. We can harness details on the spatiotemporal evolution of the rupture process from waveform similarity or coherency. A direct relation between these kinematic observations to earthquake physics is critical. Theoretical analysis indicates that high-frequency bursts can be related to abrupt changes in rupture velocity (e.g. stopping of the rupture or kinks on the fault, e.g. Madariaga, 1976; Madariaga et al., 2006). Moreover, the BP images are thought to be equivalent to either slip or slip rate on the fault, provided that the Green's functions from the sources to the receivers are incoherent delta functions (Fukuhata et al., 2014). Furthermore, recent studies propose that the frequency dependent features of BP results can reflect the stress status, frictional and/or geometrical heterogeneity on the fault surface (e.g. Huang et al., 2012; Lay et al., 2012; Yao et al., 2013; Yin et al., 2016, etc.). With this promising background, we attempt to relate the BP results and earthquake source process through kinematic and dynamic source models. We build synthetic seismic waveforms and trace them back to the fault surface using synthetic backprojection. We carry the 3D kinematic source models using Crempien and Archuleta (2014) and the 2D kinematic models using FDMap (Dunham et al., 2011). By varying the source models such as the friction laws and fault geometries, we directly compare the BP results with the ground truth earthquake sources and further explore the possible relation to the source properties. To simplify our problem and exclude the potential effects from complex earth structure, our tests are carried out in a purely elastic whole space, allowing us to solve analytically for the far-field body waves. From these systematical tests and comparisons, we aim at building a comprehensive relation between

  12. Saltstone SDU6 Modeling Study

    International Nuclear Information System (INIS)

    Lee, Si Y.; Hyun, Sinjae

    2013-01-01

    A new disposal unit, designated as Saltstone Disposal Unit 6 (SDU6), is being designed for support of site accelerated closure goals and salt waste projections identified in the new Liquid Waste System Plan. The unit is a cylindrical disposal cell of 375 ft in diameter and 43 ft in height, and it has a minimum 30 million gallons of capacity. SRNL was requested to evaluate the impact of an increased grout placement height on the flow patterns radially spread on the floor and to determine whether grout quality is impacted by the height. The primary goals of the work are to develop the baseline Computational Fluid Dynamics (CFD) model and to perform the evaluations for the flow patterns of grout material in SDU6 as a function of elevation of grout discharge port and grout rheology. Two transient grout models have been developed by taking a three-dimensional multiphase CFD approach to estimate the domain size of the grout materials radially spread on the facility floor and to perform the sensitivity analysis with respect to the baseline design and operating conditions such as elevation height of the discharge port and fresh grout properties. For the CFD modeling calculations, air-grout Volume of Fluid (VOF) method combined with Bingham plastic and time-dependent grout models were used for examining the impact of fluid spread performance for the initial baseline configurations and to evaluate the impact of grout pouring height on grout quality. The grout quality was estimated in terms of the air volume fraction for the grout layer formed on the SDU6 floor, resulting in the change of grout density. The study results should be considered as preliminary scoping analyses since benchmarking analysis is not included in this task scope. Transient analyses with the Bingham plastic model were performed with the FLUENTTM code on the high performance parallel computing platform in SRNL. The analysis coupled with a transient grout aging model was performed by using ANSYS-CFX code

  13. Discussion of various models related to cloud performance

    OpenAIRE

    Kande, Chaitanya Krishna

    2015-01-01

    This paper discusses the various models related to cloud computing. Knowing the metrics related to infrastructure is very critical to enhance the performance of cloud services. Various metrics related to clouds such as pageview response time, admission control and enforcing elasticity to cloud infrastructure are very crucial in analyzing the characteristics of the cloud to enhance the cloud performance.

  14. Relative contributions of secondary organic aerosol formation from toluene, xylenes, isoprene, and monoterpenes in Hong Kong and Guangzhou in the Pearl River Delta, China: an emission-based box modeling study

    Science.gov (United States)

    Wang, Siyuan; Wu, Dongwei; Wang, Xin-Ming; Fung, Jimmy Chi-Hung; Yu, Jian Zhen

    2013-01-01

    Secondary organic aerosols (SOA) formed from common anthropogenic and biogenic volatile organic compounds (VOCs) account for a significant portion of organic particulate matter in the ambient atmosphere. The Pearl River Delta (PRD) in southern China, located in the subtropics and as a region with intensive manufacturing industries, has significant emissions of both anthropogenic and biogenic VOCs. Two recent SOA tracer-based measurement studies, one in Hong Kong (located at the mouth of the PRD) and the other at a site 20 to 50 km downwind of urban Guangzhou districts in the middle of the PRD, show a rather considerable difference in the relative SOA contributions from one group of two biogenic VOCs (isoprene and monoterpenes) and one group of anthropogenic VOCs, namely, toluene + xylenes. In Hong Kong, more SOA was formed from isoprene and monoterpenes than from toluene and xylenes, although the relative contributions of the two groups of VOCs were reversed at the site downwind of Guangzhou. An emission-based 0-D box model has been developed to investigate this issue. The emission inputs of major inorganic pollutants and VOCs are generated using the programs Sparse Matrix Operator Kernel Emissions and Model of Emissions of Gases and Aerosols from Nature for this region. Toluene/xylene emissions in Guangzhou are more than twice that in Hong Kong whereas isoprene and monoterpenes emissions were similar at the two locations. The model incorporates a CB05 chemical mechanism and gas-particle partitioning of condensable VOC oxidation products to simulate SOA formation from major VOCs including isoprene, monoterpenes, toluene, and xylenes. The model-simulated VOCs fall within the range of ambient observations, demonstrating reasonable representation of emissions and oxidation of VOCs. The model simulates the sum of the SOA formation from isoprene, monoterpenes, and toluene + xylenes. In Hong Kong, monoterpenes are the major contributor (up to 70%), followed by isoprene

  15. Formation of algae growth constitutive relations for improved algae modeling.

    Energy Technology Data Exchange (ETDEWEB)

    Gharagozloo, Patricia E.; Drewry, Jessica Louise.

    2013-01-01

    This SAND report summarizes research conducted as a part of a two year Laboratory Directed Research and Development (LDRD) project to improve our abilities to model algal cultivation. Algae-based biofuels have generated much excitement due to their potentially large oil yield from relatively small land use and without interfering with the food or water supply. Algae mitigate atmospheric CO2 through metabolism. Efficient production of algal biofuels could reduce dependence on foreign oil by providing a domestic renewable energy source. Important factors controlling algal productivity include temperature, nutrient concentrations, salinity, pH, and the light-to-biomass conversion rate. Computational models allow for inexpensive predictions of algae growth kinetics in these non-ideal conditions for various bioreactor sizes and geometries without the need for multiple expensive measurement setups. However, these models need to be calibrated for each algal strain. In this work, we conduct a parametric study of key marine algae strains and apply the findings to a computational model.

  16. Application distribution model and related security attacks in VANET

    Science.gov (United States)

    Nikaein, Navid; Kanti Datta, Soumya; Marecar, Irshad; Bonnet, Christian

    2013-03-01

    In this paper, we present a model for application distribution and related security attacks in dense vehicular ad hoc networks (VANET) and sparse VANET which forms a delay tolerant network (DTN). We study the vulnerabilities of VANET to evaluate the attack scenarios and introduce a new attacker`s model as an extension to the work done in [6]. Then a VANET model has been proposed that supports the application distribution through proxy app stores on top of mobile platforms installed in vehicles. The steps of application distribution have been studied in detail. We have identified key attacks (e.g. malware, spamming and phishing, software attack and threat to location privacy) for dense VANET and two attack scenarios for sparse VANET. It has been shown that attacks can be launched by distributing malicious applications and injecting malicious codes to On Board Unit (OBU) by exploiting OBU software security holes. Consequences of such security attacks have been described. Finally, countermeasures including the concepts of sandbox have also been presented in depth.

  17. Relational grounding facilitates development of scientifically useful multiscale models

    Directory of Open Access Journals (Sweden)

    Lam Tai

    2011-09-01

    Full Text Available Abstract We review grounding issues that influence the scientific usefulness of any biomedical multiscale model (MSM. Groundings are the collection of units, dimensions, and/or objects to which a variable or model constituent refers. To date, models that primarily use continuous mathematics rely heavily on absolute grounding, whereas those that primarily use discrete software paradigms (e.g., object-oriented, agent-based, actor typically employ relational grounding. We review grounding issues and identify strategies to address them. We maintain that grounding issues should be addressed at the start of any MSM project and should be reevaluated throughout the model development process. We make the following points. Grounding decisions influence model flexibility, adaptability, and thus reusability. Grounding choices should be influenced by measures, uncertainty, system information, and the nature of available validation data. Absolute grounding complicates the process of combining models to form larger models unless all are grounded absolutely. Relational grounding facilitates referent knowledge embodiment within computational mechanisms but requires separate model-to-referent mappings. Absolute grounding can simplify integration by forcing common units and, hence, a common integration target, but context change may require model reengineering. Relational grounding enables synthesis of large, composite (multi-module models that can be robust to context changes. Because biological components have varying degrees of autonomy, corresponding components in MSMs need to do the same. Relational grounding facilitates achieving such autonomy. Biomimetic analogues designed to facilitate translational research and development must have long lifecycles. Exploring mechanisms of normal-to-disease transition requires model components that are grounded relationally. Multi-paradigm modeling requires both hyperspatial and relational grounding.

  18. Relational grounding facilitates development of scientifically useful multiscale models.

    Science.gov (United States)

    Hunt, C Anthony; Ropella, Glen E P; Lam, Tai ning; Gewitz, Andrew D

    2011-09-27

    We review grounding issues that influence the scientific usefulness of any biomedical multiscale model (MSM). Groundings are the collection of units, dimensions, and/or objects to which a variable or model constituent refers. To date, models that primarily use continuous mathematics rely heavily on absolute grounding, whereas those that primarily use discrete software paradigms (e.g., object-oriented, agent-based, actor) typically employ relational grounding. We review grounding issues and identify strategies to address them. We maintain that grounding issues should be addressed at the start of any MSM project and should be reevaluated throughout the model development process. We make the following points. Grounding decisions influence model flexibility, adaptability, and thus reusability. Grounding choices should be influenced by measures, uncertainty, system information, and the nature of available validation data. Absolute grounding complicates the process of combining models to form larger models unless all are grounded absolutely. Relational grounding facilitates referent knowledge embodiment within computational mechanisms but requires separate model-to-referent mappings. Absolute grounding can simplify integration by forcing common units and, hence, a common integration target, but context change may require model reengineering. Relational grounding enables synthesis of large, composite (multi-module) models that can be robust to context changes. Because biological components have varying degrees of autonomy, corresponding components in MSMs need to do the same. Relational grounding facilitates achieving such autonomy. Biomimetic analogues designed to facilitate translational research and development must have long lifecycles. Exploring mechanisms of normal-to-disease transition requires model components that are grounded relationally. Multi-paradigm modeling requires both hyperspatial and relational grounding.

  19. Modelling drug-related morbidity in Sweden using an expert panel of physicians

    OpenAIRE

    Hakkarainen, Katja M; Alström, Daniel; Hägg, Staffan; Carlsten, Anders; Gyllensten, Hanna

    2012-01-01

    PURPOSE: In modelling studies using pharmacists' opinions, drug-related morbidity (DRM) and preventable DRM have been more common than in observational studies, and the resulting costs are extensive. Modelling studies' estimates may vary depending on informants' profession. The purpose of this modelling study was to estimate the proportion of patients with DRM and preventable DRM and the cost of illness (COI) of DRM in Sweden based on physicians' expert opinions. METHOD: A conceptual model of...

  20. Computational Model for Internal Relative Humidity Distributions in Concrete

    Directory of Open Access Journals (Sweden)

    Wondwosen Ali

    2014-01-01

    Full Text Available A computational model is developed for predicting nonuniform internal relative humidity distribution in concrete. Internal relative humidity distribution is known to have a direct effect on the nonuniform drying shrinkage strains. These nonuniform drying shrinkage strains result in the buildup of internal stresses, which may lead to cracking of concrete. This may be particularly true at early ages of concrete since the concrete is relatively weak while the difference in internal relative humidity is probably high. The results obtained from this model can be used by structural and construction engineers to predict critical drying shrinkage stresses induced due to differential internal humidity distribution. The model uses finite elment-finite difference numerical methods. The finite element is used to space discretization while the finite difference is used to obtain transient solutions of the model. The numerical formulations are then programmed in Matlab. The numerical results were compared with experimental results found in the literature and demonstrated very good agreement.

  1. A Semi-Tychonic Model in General relativity

    Science.gov (United States)

    Murphy, George L.

    1998-10-01

    In the sixteenth century Tycho Brahe proposed a geocentric model of the solar system kinematically equivalent to the heliocentric Copernican model. There has been disagreement even among prominent relativists over whether or not relativity validates use of a geocentric model. Tycho's desire for a non-rotating earth cannot be satisfied, but we demonstrate here dynamical equivalence between a Copernican and a "semi-Tychonic" model by using an appropriate accelerated reference frame in general relativity. (The idea of absolute space in Newtonian mechanics makes use of Einstein's theory desirable even in the Newtonian approximation.) Optical questions are easily dealt with. Our treatment provides a satisfactory answer for the important historical question concerning geocentric and heliocentric models, and is also of pedagogic value. In addition, it gives insights into the real generality of general relativity, the nature of the relativistic equations of motion, and the analogy between coordinate and gauge transformations.

  2. Experimental study and thermodynamic modeling of the phase relation in the Fe-S-Si system with implications for the distribution of S and Si in a partially solidified core

    Science.gov (United States)

    Tao, R.; Fei, Y.

    2017-12-01

    Planetary cooling leads to solidification of any initially molten metallic core. Some terrestrial cores (e.g. Mercury) are formed and differentiated under relatively reduced conditions, and they are thought to be composed of Fe-S-Si. However, there are limited understanding of the phase relations in the Fe-S-Si system at high pressure and temperature. In this study, we conducted high-pressure experiments to investigate the phase relations in the Fe-S-Si system up to 25 GPa. Experimental results show that the liquidus and solidus in this study are slightly lower than those in the Fe-S binary system for the same S concentration in liquid at same pressure. The Fe3S, which is supposed to be the stable sub-solidus S-bearing phase in the Fe-S binary system above 17 GPa, is not observed in the Fe-S-Si system at 21 GPa. Almost all S prefers to partition into liquid, while the distribution of Si between solid and liquid depends on experimental P and T conditions. We obtained the partition coefficient log(KDSi) by fitting the experimental data as a function of P, T and S concentration in liquid. At a constant pressure, the log(KDSi) linearly decreases with 1/T(K). With increase of pressure, the slopes of linear correlation between log(KDSi) and 1/T(K) decreases, indicating that more Si partitions into solid at higher pressure. In order to interpolate and extrapolate the phase relations over a wide pressure and temperature range, we established a comprehensive thermodynamic model in the Fe-S-Si system. The results will be used to constrain the distribution of S and Si between solid inner core and liquid outer core for a range of planet sizes. A Si-rich solid inner core and a S-rich liquid outer core are suggested for an iron-rich core.

  3. Androgyny and Attachment Security: Two Related Models of Optimal Personality.

    Science.gov (United States)

    Shaver, Phillip R.; And Others

    1996-01-01

    Three studies explore similarities between attachment style typologies and sex role typologies. Both are defined by pairs of dimensions: self model and other model (attachment styles); masculinity, or agency, and femininity, or communion (sex role orientations). Discusses results. (KW)

  4. Model experiments related to outdoor propagation over an earth berm

    DEFF Research Database (Denmark)

    Rasmussen, Karsten Bo

    1994-01-01

    A series of scale model experiments related to outdoor propagation over an earth berm is described. The measurements are performed with a triggered spark source. The results are compared with data from an existing calculation model based upon uniform diffraction theory. Comparisons are made...

  5. Bianchi type IX string cosmological model in general relativity

    Indian Academy of Sciences (India)

    Abstract. We have investigated Bianchi type IX string cosmological models in general relativity. To get a determinate solution, we have assumed a condition p = λ i.e. rest energy density for a cloud of strings is equal to the string tension density. The various physical and geometrical aspects of the models are also discussed.

  6. Bianchi type IX string cosmological model in general relativity

    Indian Academy of Sciences (India)

    We have investigated Bianchi type IX string cosmological models in general relativity. To get a determinate solution, we have assumed a condition ρ= i.e. rest energy density for a cloud of strings is equal to the string tension density. The various physical and geometrical aspects of the models are also discussed.

  7. Applying the social relations model to self and peer evaluations

    NARCIS (Netherlands)

    G.J. Greguras; C. Robie; M.Ph. Born (Marise)

    2001-01-01

    textabstractPeer evaluations of performance increasingly are being used to make organizational decisions and to provide individuals with performance related feedback. Using Kenny’s social relations model (SRM), data from 14 teams of undergraduate students who completed performance ratings of

  8. Latent Stochastic Actor Oriented Models for Relational Event Data

    Science.gov (United States)

    2012-03-15

    L-SAOMs for Relational Events Latent Stochastic Actor Oriented Models for Relational Event Data J.A. Lospinoso12 J.H. Koskinen2 T.A.B. Snijders2......PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) US

  9. Undergraduate female science-related career choices: A phenomenological study

    Science.gov (United States)

    Curry, Kathy S.

    This qualitative phenomenological study used a modified Groenewald's five steps method with semi-structured, recorded, and transcribed interviews to focus on the underrepresentation of females in science-related careers. The study explored the lived experiences of a purposive sample of 25 senior female college students attending a college in Macon, Georgia. Ten major themes emerged from the research study that included (a) journey to a science-related career; (b) realization of career interest; (c) family support (d) society's role; (e) professors' treatment of students; (f) lack of mentors and models; (g) gender and career success; (h) females and other disadvantages in science-related careers; (i) rewards of the journey; and (j) advice for the journey. The three minor themes identified were (a) decision-making; (b) career awareness; and (c) guidance. The key findings revealed that females pursuing a science degree or subsequent science-related career, shared their experience with other females interested in science as a career choice, dealt with barriers standing in the way of their personal goals, lack role models, and received little or no support from family and friends. The study findings may offer information to female college students interested in pursuing science-related careers and further foundational research on gender disparities in career choice.

  10. The effect of an online video intervention 'Movie Models' on specific parenting practices and parental self-efficacy related to children's physical activity, screen-time and healthy diet: a quasi experimental study.

    Science.gov (United States)

    De Lepeleere, Sara; De Bourdeaudhuij, Ilse; Cardon, Greet; Verloigne, Maïté

    2017-04-27

    younger children (6-9 years old). 'Movie Models' was effective in increasing some important parenting practices and parental self-efficacy related to PA, screen-time and healthy diet in children. Therefore, the current study is an important first step in promoting effective parenting-related factors, and possibly increasing children's healthy diet and PA, and decreasing screen-time. NCT02278809 in ClinicalTrials.gov on October 28, 2014 (retrospectively registered).

  11. PROBABILISTIC RELATIONAL MODELS OF COMPLETE IL-SEMIRINGS

    OpenAIRE

    Tsumagari, Norihiro

    2012-01-01

    This paper studies basic properties of probabilistic multirelations which are generalized the semantic domain of probabilistic systems and then provides two probabilistic models of complete IL-semirings using probabilistic multirelations. Also it is shown that these models need not be models of complete idempotentsemirings.

  12. Campus network security model study

    Science.gov (United States)

    Zhang, Yong-ku; Song, Li-ren

    2011-12-01

    Campus network security is growing importance, Design a very effective defense hacker attacks, viruses, data theft, and internal defense system, is the focus of the study in this paper. This paper compared the firewall; IDS based on the integrated, then design of a campus network security model, and detail the specific implementation principle.

  13. Urban Studies: A Learning Model.

    Science.gov (United States)

    Cooper, Terry L.; Sundeen, Richard

    1979-01-01

    The urban studies learning model described in this article was found to increase students' self-esteem, imbue a more flexible and open perspective, contribute to the capacity for self-direction, produce increases on the feeling reactivity, spontaneity, and acceptance of aggression scales, and expand interpersonal competence. (Author/WI)

  14. Infinite Multiple Membership Relational Modeling for Complex Networks

    DEFF Research Database (Denmark)

    Mørup, Morten; Schmidt, Mikkel Nørgaard; Hansen, Lars Kai

    Learning latent structure in complex networks has become an important problem fueled by many types of networked data originating from practically all fields of science. In this paper, we propose a new non-parametric Bayesian multiplemembership latent feature model for networks. Contrary to existing...... multiplemembership models that scale quadratically in the number of vertices the proposedmodel scales linearly in the number of links admittingmultiple-membership analysis in large scale networks. We demonstrate a connection between the single membership relational model and multiple membership models and show...

  15. Obesidade induzida por consumo de dieta: modelo em roedores para o estudo dos distúrbios relacionados com a obesidade Diet-induced obesity: rodent model for the study of obesity-related disorders

    Directory of Open Access Journals (Sweden)

    Tiago Campos Rosini

    2012-06-01

    mostly to genetic mutations, but this model is far from that found in humans. The use of hypercaloric or hyperlipidemic diets has been used as a model of obesity induction in animals, because of its similarity to the genesis and metabolic responses caused by obesity in humans. The objective of this review is to show the different types of diets used to induce obesity in rodents, the induced metabolic alterations, and to identify some points that should be taken into account so that the model can be effective for the study of obesity-related complications. A search was performed in the PubMed database using the following keywords: 1- "hypercaloric diet" AND "rodent", 2- "hyperlipidic diet" AND "rodent", selecting those considered the most relevant according to the following criteria: date of publication (1995-2011; the use of wild-type animals; detailed description of the diet used and analysis of biochemical and vascular parameters of interest. References were included to introduce subjects such as the increased prevalence of obesity and questions related to the genesis of obesity in humans. The model of diet-induced obesity in rodents can be considered effective when the objective is the study of the physiopathology of metabolic and vascular complications associated with obesity.

  16. Gut-related studies of radionuclide toxicity

    International Nuclear Information System (INIS)

    Sullivan, M.F.

    1983-01-01

    This project is concerned with the behavior of radioactive materials that mayu be ingested as a consequence of a reactor accident, unavoidable occupational exposure, or after release to the environment and incorporation into the food chain. Current emphasis is on evaluating hazards from ingested actinides as a function of animal age, species, nutrition, and diet, or chemicophysical state of the actinide. We are also concerned with the behavior of actinides that are inhaled and pass through the gastrointestinal (GI) tract after clearance from the lungs. Recent experiments showed that adult swine absorbed more 238 Pu nitrate than had previously been indicated in studies with 239 Pu nitrate, three times more than is absorbed by rats. Absorption of 238 Pu by rats on a vitamin-D-deficient diet was about 10 times higher than absorption by rats on a balanced diet. Studies on the effect of chemical form on actinide absorption showed that the citrate forms of 238 Pu, 241 Am and 244 Cm were transported in higher quantities than the nitrate forms across the intestine. Citrate had no effect on the 237 Np transport, but the mass of isotope administered was found to be important. Absorption by neonates was inversely related to the mass of neptunium gavaged, in contrast to the effect of mass on neptunium absorption by adult rats. Organic binding of 238 Pu in liver tissue, in situ, resulted in decreased absorption by adult or neonatal rats. These results demonstrate that animal age, species and nutritional state are important factors in determining GI absorption of actinide compounds. Chemical form and oxidation state also influence transport. These effects vary with animal age and with the actinide in question

  17. Present status of the VMI and related models

    International Nuclear Information System (INIS)

    Scharff-Goldhaber, G.

    1980-05-01

    This article traces the evolution of the Variable Moment of Inertia model in its relation to the shell model, the Bohr-Mottelson model and the Interacting Boson Model. The discovery of a new type of spectrum, that of pseudomagic nuclei (isobars of doubly magic nuclei) is reported, and an explanation for their dynamics is suggested. The type of rotational motion underlying the ground state band of an e-e nucleus is shown to depend on whether the minimum number of valence nucleon pairs of one kind (neutrons or protons) is less than or equal to 2 or > 2. In the former case the alpha-dumbbell model holds; in the latter the two-fluid model

  18. Regenerative-Relational Tritangtu: Sundanese Triadic Transformation Model

    Directory of Open Access Journals (Sweden)

    Wanda Listiani

    2013-06-01

    Full Text Available ABSTRACT   Tritangtu or Trinity mindset is a Sundanese and Minang community cosmology that consists of three entities (three patterns. Tritangtu as the local wisdom is also underlying the creative actors mental structure on making their works either in the form of performance, artifacts philosophy value, or in other cultural products in Indonesian community. This study used ethnographic method with data collection techniques were participant observation in-depth interviews and documentation. The object of study is the creative actors practice at the design field in Bandung. The result of study pointed out the Sundanese Tritangtu transformation from the permanent struc- ture to dynamic structure. The change in the structure is determined by the relation between the de- sign elements forming structure with the global market segmentation. Lending Sundanese identity markers, especially the folk culture or the past traditions is regenerative efforts to harmonize the three patterns in encountering and winning the free-market competition in Indonesia.   Keyword:  Tritangtu, Sundanese Triadic Transformation ModelAbstrak   Tritangtu atau pola pikir tritunggal merupakan kosmologi masyarakat Sunda dan Minang yang terdiri dari tiga entitas (pola tiga. Tritangtu sebagai kearifan lokal juga melatarbelakangi struktur mental pelaku kreatif dalam membuat karya baik berupa pertunjukan, nilai filosofi artefak mau- pun produk budaya lainnya di masyarakat Indonesia. Penelitian ini menggunakan metode etnografi dengan teknik pengumpulan data observasi partisipasi, wawancara mendalam dan dokumentasi. Obyek penelitian ini adalah praktik pelaku kreatif di bidang desain di Bandung. Hasil penelitian ini menunjukkan adanya transformasi tritangtu Sunda dari struktur yang tetap menjadi struktur dinamis. Perubahan struktur ini ditentukan oleh relasi antar struktur pembentuk unsur desain de- ngan segmentasi pasar global. Peminjaman penanda identitas Sunda khususnya budaya

  19. Thermodynamics of Paint Related Systems with Engineering Models

    DEFF Research Database (Denmark)

    Lindvig, Thomas; Michelsen, Michael Locht; Kontogeorgis, Georgios

    2001-01-01

    to solid surfaces and drying. Many engineering models have been applied over the last decades for solutions with commoditity polymers. In this work the performance of some of these models is investigated for paint-related systems, focusing on those drying by the so-called " lacquer mechanism " (evaporation......Paints are complex materials composed of polymers (binders) dissolved in one or more solvents, pigments, and other additives. The thermodynamics of such systems is essential, for example, for selecting improved solvents and understanding a number of phenomena related especially! to adhesion...... that, despite the uncertainties involved, several models yield reasonably accurate activity coefficients, even at infinite dilution. Thus, engineering models may be useful for solvent selection via semiempirical rules of thumb, which are based on thermodynamic considerations....

  20. Amplitudes, recursion relations and unitarity in the Abelian Higgs model

    Science.gov (United States)

    Kleiss, Ronald; Luna, Oscar Boher

    2017-12-01

    The Abelian Higgs model forms an essential part of the electroweak standard model: it is the sector containing only Z0 and Higgs bosons. We present a diagram-based proof of the tree-level unitarity of this model inside the unitary gauge, where only physical degrees of freedom occur. We derive combinatorial recursion relations for off-shell amplitudes in the massless approximation, which allows us to prove the cancellation of the first two orders in energy of unitarity-violating high-energy behaviour for any tree-level amplitude in this model. We describe a deformation of the amplitudes by extending the physical phase space to at least 7 spacetime dimensions, which leads to on-shell recursion relations à la BCFW. These lead to a simple proof that all on-shell tree amplitudes obey partial-wave unitarity.

  1. Relating mesocarnivore relative abundance to anthropogenic land-use with a hierarchical spatial count model

    Science.gov (United States)

    Crimmins, Shawn M.; Walleser, Liza R.; Hertel, Dan R.; McKann, Patrick C.; Rohweder, Jason J.; Thogmartin, Wayne E.

    2016-01-01

    There is growing need to develop models of spatial patterns in animal abundance, yet comparatively few examples of such models exist. This is especially true in situations where the abundance of one species may inhibit that of another, such as the intensively-farmed landscape of the Prairie Pothole Region (PPR) of the central United States, where waterfowl production is largely constrained by mesocarnivore nest predation. We used a hierarchical Bayesian approach to relate the distribution of various land-cover types to the relative abundances of four mesocarnivores in the PPR: coyote Canis latrans, raccoon Procyon lotor, red fox Vulpes vulpes, and striped skunk Mephitis mephitis. We developed models for each species at multiple spatial resolutions (41.4 km2, 10.4 km2, and 2.6 km2) to address different ecological and management-related questions. Model results for each species were similar irrespective of resolution. We found that the amount of row-crop agriculture was nearly ubiquitous in our best models, exhibiting a positive relationship with relative abundance for each species. The amount of native grassland land-cover was positively associated with coyote and raccoon relative abundance, but generally absent from models for red fox and skunk. Red fox and skunk were positively associated with each other, suggesting potential niche overlap. We found no evidence that coyote abundance limited that of other mesocarnivore species, as might be expected under a hypothesis of mesopredator release. The relationships between relative abundance and land-cover types were similar across spatial resolutions. Our results indicated that mesocarnivores in the PPR are most likely to occur in portions of the landscape with large amounts of agricultural land-cover. Further, our results indicated that track-survey data can be used in a hierarchical framework to gain inferences regarding spatial patterns in animal relative abundance.

  2. Probing culture in the head: the neural correlates of relational models.

    Science.gov (United States)

    Dien, Joseph; Karuzis, Valerie; Haarmann, Henk J

    2018-04-03

    Relational Models Theory or RMT proposes that there are four universal ways in which socio-economic relations can be organized. According to the RMT, each of its four relational models (Communal Sharing, Authority Ranking, Equality Matching, and Market Pricing) is associated with a distinct cognitive representation, with a cumulative pattern in which each relational model is a superset of the next lower model. This report for the first time uses a combination of cognitive and the social neuroscience to put this model to the test. RMT proposes that members of every culture use all four relational models, just in different proportions. It should therefore be possible to study their neural correlates in a mono-cultural sample. In this study, thirty-nine European-American students were imaged in a 3T Siemens Trio with a 24-channel head coil while rating the extent to which each relational model organized relationships with each of thirty-two acquaintances/friend/relatives in a boxcar design. FreeSurfer Functional Analysis Stream (FS-FAST) analyses revealed distinct patterns of activation for each of the relational models. The activations did not follow a cumulative hierarchical pattern, suggestive that this aspect of the RMT model should be revised.

  3. Kuala Kemaman hydraulic model study

    International Nuclear Information System (INIS)

    Abdul Kadir Ishak

    2005-01-01

    There The problems facing the area of Kuala Kemaman are siltation and erosion at shoreline. The objectives of study are to assess the best alignment of the groyne alignment, to ascertain the most stable shoreline regime and to investigate structural measures to overcome the erosion. The scope of study are data collection, wave analysis, hydrodynamic simulation and sediment transport simulation. Numerical models MIKE 21 are used - MIKE 21 NSW, for wind-wave model, which describes the growth, decay and transformation of wind-generated waves and swell in nearshore areas. The study takes into account effects of refraction and shoaling due to varying depth, energy dissipation due to bottom friction and wave breaking, MIKE 21 HD - modelling system for 2D free-surface flow which to stimulate the hydraulics phenomena in estuaries, coastal areas and seas. Predicted tidal elevation and waves (radiation stresses) are considered into study while wind is not considered. MIKE 21 ST - the system that calculates the rates of non-cohesive (sand) sediment transport for both pure content and combined waves and current situation

  4. A STUDY OF SYMBOLIC RELATIONS IN PUBLIC TRANSPORT

    Directory of Open Access Journals (Sweden)

    ANDREI BALAN

    2011-04-01

    Full Text Available This paper presents an anthropological, exploratory study of the microsocial world of public transport. Our research focuses on the symbolic relations that are being established (verbally or nonverbally between urban transport travellers that do not know each other and the consequences these relations create. Modern urban configuration forces large numbers of individuals to share public space every day. When this space becomes restrictive, symbolic relations and interpersonal behaviors such as territoriality and personal space management become clearer. Due to overcrowding, public transport is the scene of one of the most restrictive public spaces in a city. The challenge was to observe and interpret daily, casual behaviors through a sociological and psychological scheme, following the methodological tradition established by Erving Goffman and the other symbolic interactionists. Finally, our study generates a number of hypotheses and explanatory models for common practices and behaviors in trams and metros regarded from a symbolic perspective.

  5. Dataflow-Driven Crowdsourcing: Relational Models and Algorithms

    OpenAIRE

    D. A. Ustalov

    2016-01-01

    Recently, microtask crowdsourcing has become a popular approach for addressing various data mining problems. Crowdsourcing workflows for approaching such problems are composed of several data processing stages which require consistent representation for making the work reproducible. This paper is devoted to the problem of reproducibility and formalization of the microtask crowdsourcing process. A computational model for microtask crowdsourcing based on an extended relational model and a dataf...

  6. Salt marsh stability modelled in relation to sea level rise

    DEFF Research Database (Denmark)

    Bartholdy, Jesper; Bartholdy, Anders; Kroon, Aart

    2010-01-01

    Accretion on a natural backbarrier salt marsh was modeled as a function of high tide level, initial salt marsh level and distance to the source. Calibration of the model was based on up to ca 80 year old marker horizons, supplemented by 210Pb/137Cs datings and subsequent measurements of clay...... that mass depth down core can be directly related to the bulk dry density of the surface layer by means of a logarithmic function. The results allow for an evaluation of the use of marker horizons in the topmost layers and show that it is important to know the level of the marker in relation to the salt...

  7. The HEXACO and Five-Factor Models of Personality in Relation to RIASEC Vocational Interests

    Science.gov (United States)

    McKay, Derek A.; Tokar, David M.

    2012-01-01

    The current study extended the empirical research on the overlap of vocational interests and personality by (a) testing hypothesized relations between RIASEC interests and the personality dimensions of the HEXACO model, and (b) exploring the HEXACO personality model's predictive advantage over the five-factor model (FFM) in capturing RIASEC…

  8. Mathematical model II. Basic particle and special relativity

    OpenAIRE

    Nitin Ramchandra Gadre

    2011-01-01

    The basic particle electron obeys various theories like electrodynamics, quantum mechanics and special relativity. Particle under different experimental conditions behaves differently, allowing us to observe different characteristics which become basis for these theories. In this paper, we try to find out the requirements of the special relativity and suggest a mathematical particle model which can satisfy these requirements. The basic presumption is that the particle should have some structu...

  9. A Relational Model for Simulation Data to Promote Interdisciplinary Collaboration

    Science.gov (United States)

    Castronova, A. M.; Jones, A. S.; Horsburgh, J. S.

    2014-12-01

    Hydrologic modeling is an essential component to understanding the physical processes that govern water resources systems. The process representation, approach, and scale used in each model can vary greatly among scientific domains. In addition, many models use proprietary data input and output file formats making it difficult to share results among scientists. These factors limit the extent to which cross disciplinary models can grow, and as a result, restricts collaboration across academic disciplines. The heterogeneity of data formats among models also inhibits archival due to the lack of consistent metadata and the inability to quickly inspect file contents. This work investigates a method for archiving model simulation input and output time series data in an easily accessible manner. We present a relational data model for representing simulation-based data that extends the functionality of the Observations Data Model (version 2). We demonstrate its use by implementing a PostgreSQL database with geospatial support via PostGIS, and illustrate how it is used to store and retrieve data to facilitate sharing among models and scientists.

  10. Online traffic flow model applying dynamic flow-density relation

    International Nuclear Information System (INIS)

    Kim, Y.

    2002-01-01

    This dissertation describes a new approach of the online traffic flow modelling based on the hydrodynamic traffic flow model and an online process to adapt the flow-density relation dynamically. The new modelling approach was tested based on the real traffic situations in various homogeneous motorway sections and a motorway section with ramps and gave encouraging simulation results. This work is composed of two parts: first the analysis of traffic flow characteristics and second the development of a new online traffic flow model applying these characteristics. For homogeneous motorway sections traffic flow is classified into six different traffic states with different characteristics. Delimitation criteria were developed to separate these states. The hysteresis phenomena were analysed during the transitions between these traffic states. The traffic states and the transitions are represented on a states diagram with the flow axis and the density axis. For motorway sections with ramps the complicated traffic flow is simplified and classified into three traffic states depending on the propagation of congestion. The traffic states are represented on a phase diagram with the upstream demand axis and the interaction strength axis which was defined in this research. The states diagram and the phase diagram provide a basis for the development of the dynamic flow-density relation. The first-order hydrodynamic traffic flow model was programmed according to the cell-transmission scheme extended by the modification of flow dependent sending/receiving functions, the classification of cells and the determination strategy for the flow-density relation in the cells. The unreasonable results of macroscopic traffic flow models, which may occur in the first and last cells in certain conditions are alleviated by applying buffer cells between the traffic data and the model. The sending/receiving functions of the cells are determined dynamically based on the classification of the

  11. Global assemblages and structural models of International Relations

    DEFF Research Database (Denmark)

    Corry, Olaf

    2014-01-01

    Rather than consigning assemblages to the micro-politics of international relations, the chapter argues that assemblages can also be seen to play a role in the ‘grand’ structures of international relations. Structural IR theory normally only considers how subjects are ordered – hierarchically......, anarchically, in core-periphery relations or in terms of networks. However, not only subjects but also assemblages – the bringing together of previously unconnected elements into novel constellations – play a critical role in structuring international relations. More specifically, one sub......-category of assemblages – those constructed as malleable and governable which I call ‘governance-objects’ – is central to structure in international relations. The chapter begins with standard definitions of what structures are – patterns of interaction between elements – and briefly covers the range of models currently...

  12. Metabolism related toxicity of diclofenac in yeast as model system

    NARCIS (Netherlands)

    van Leeuwen, J.S.; Vredenburg, G.; Dragovic, S.; Tjong, T.F.; Vos, J.C.; Vermeulen, N.P.E.

    2010-01-01

    Diclofenac is a widely used drug that can cause serious hepatotoxicity, which has been linked to metabolism by cytochrome P450s (P450). To investigate the role of oxidative metabolites in diclofenac toxicity, a model for P450-related toxicity was set up in Saccharomyces cerevisiae. We expressed a

  13. Bianchi type-V string cosmological models in general relativity

    Indian Academy of Sciences (India)

    Abstract. Bianchi type-V string cosmological models in general relativity are investigated. To get the exact solution of Einstein's field equations, we have taken some scale transformations used by Camci et al [Astrophys. Space Sci. 275, 391 (2001)]. It is shown that Einstein's field equations are solvable for any arbitrary ...

  14. Bianchi type-V string cosmological models in general relativity

    Indian Academy of Sciences (India)

    Bianchi type-V string cosmological models in general relativity are investigated. To get the exact solution of Einstein's field equations, we have taken some scale transformations used by Camci et al [Astrophys. Space Sci. 275, 391 (2001)]. It is shown that Einstein's field equations are solvable for any arbitrary cosmic scale ...

  15. Reciprocal Relations between Work-Related Authenticity and Intrinsic Motivation, Work Ability and Depressivity: A Two-Wave Study

    OpenAIRE

    Emmerich, Astrid I.; Rigotti, Thomas

    2017-01-01

    This study investigates the role of context-specific authenticity at work for work-related outcomes (intrinsic motivation, work ability) and depressivity. Furthermore reciprocal relations between work-related authenticity and healthy psychological functioning are investigated. Longitudinal data from 1,243 employees from 63 subsidiaries of a non-profit organization in the social sector were analyzed using multilevel structural equation modeling. Work-related authenticity at T1 predicted work a...

  16. Dataflow-Driven Crowdsourcing: Relational Models and Algorithms

    Directory of Open Access Journals (Sweden)

    D. A. Ustalov

    2016-01-01

    Full Text Available Recently, microtask crowdsourcing has become a popular approach for addressing various data mining problems. Crowdsourcing workflows for approaching such problems are composed of several data processing stages which require consistent representation for making the work reproducible. This paper is devoted to the problem of reproducibility and formalization of the microtask crowdsourcing process. A computational model for microtask crowdsourcing based on an extended relational model and a dataflow computational model has been proposed. The proposed collaborative dataflow computational model is designed for processing the input data sources by executing annotation stages and automatic synchronization stages simultaneously. Data processing stages and connections between them are expressed by using collaborative computation workflows represented as loosely connected directed acyclic graphs. A synchronous algorithm for executing such workflows has been described. The computational model has been evaluated by applying it to two tasks from the computational linguistics field: concept lexicalization refining in electronic thesauri and establishing hierarchical relations between such concepts. The “Add–Remove–Confirm” procedure is designed for adding the missing lexemes to the concepts while removing the odd ones. The “Genus–Species–Match” procedure is designed for establishing “is-a” relations between the concepts provided with the corresponding word pairs. The experiments involving both volunteers from popular online social networks and paid workers from crowdsourcing marketplaces confirm applicability of these procedures for enhancing lexical resources. 

  17. Adolescent Girls' Self-Concept and Its Related Factors Based on Roy Adaptation Model

    OpenAIRE

    M. Basiri Moghadam; SH. Khosravan; L. Sadeghmoghadam; N. Ebrahimi Senoo

    2017-01-01

    Aims: One of the most important factors of individual health in the adolescents is the self-concept. As a nursing model, the Roy adaptation model mainly investigates the factor. The aim of the study was to investigate the self-concept and its related factors in the adolescent girls in Gonabad Township, based on the Roy adaptation model. Instrument & Methods: In the descriptive cross-sectional study, 270 adolescent girls were studied in Gonabad Township, Iran, in 2015. The subjects were s...

  18. Experimental study of chemotherapy related leukocytopenia treated ...

    African Journals Online (AJOL)

    ... the positive control drug is G-CSF, respectively fill five kinds of peroal Leucocyte increasing drugs (Qijiao Shengbai Capsule, Weixuening Granule, Compound Zaofan Pill, Berbamine and Leucogen Tablets) in the stomach, the experimental group was divided into normal control group (group A), model group (group B), ...

  19. Cardinal Direction Relations Query Modeling Based on Geo-Ontology

    Science.gov (United States)

    Zhu, X.; Chen, D.; Zhou, C.; Li, M.; Xiao, W.

    2012-08-01

    Direction relations, as an important spatial relationship, is simply expressed as object prosperity in traditional geo-ontology. The lacking of explicit specifications and reasoning rules of direction relations in geo-ontology result in the difficult or inflexible of spatial reasoning. Also, digital gazetteers provide information on named features, linking the feature's name with its location and its type. Although the location information is incomplete and not exact, the implicit spatial information, for example spatial relationships and spatial scale, can be extract using the appropriate models based on geo-ontology. In this paper, we proposed a novel conceptual framework of direction relations in order to formalize the semantics and implicit information of direction relations, and present an extraction algorithm of implicit information based on previous researches, which will produce a complete query instance of direction relations. At last, the most suitable direction physical model is recommended to calculation module according to relevant rules. And the experimental results show that this direction query model not only extracted the implicit information effectively, but also made a reasonable interpretation for the user's intention.

  20. Parametric study of a thorium model

    International Nuclear Information System (INIS)

    Lourenco, M.C.; Lipsztein, J.L.; Szwarcwald, C.L.

    2002-01-01

    Models for radionuclides distribution in the human body and dosimetry involve assumptions on the biokinetic behavior of the material among compartments representing organs and tissues in the body. One of the most important problem in biokinetic modeling is the assignment of transfer coefficients and biological half-lives to body compartments. In Brazil there are many areas of high natural radioactivity, where the population is chronically exposed to radionuclides of the thorium series. The uncertainties of the thorium biokinetic model are a major cause of uncertainty in the estimates of the committed dose equivalent of the population living in high background areas. The purpose of this study is to discuss the variability in the thorium activities accumulated in the body compartments in relation to the variations in the transfer coefficients and compartments biological half-lives of a thorium-recycling model for continuous exposure. Multiple regression analysis methods were applied to analyze the results. (author)

  1. Dispersion Relations for Electroweak Observables in Composite Higgs Models

    CERN Document Server

    Contino, Roberto

    2015-12-14

    We derive dispersion relations for the electroweak oblique observables measured at LEP in the context of $SO(5)/SO(4)$ composite Higgs models. It is shown how these relations can be used and must be modified when modeling the spectral functions through a low-energy effective description of the strong dynamics. The dispersion relation for the parameter $\\epsilon_3$ is then used to estimate the contribution from spin-1 resonances at the 1-loop level. Finally, it is shown that the sign of the contribution to the $\\hat S$ parameter from the lowest-lying spin-1 states is not necessarily positive definite, but depends on the energy scale at which the asymptotic behavior of current correlators is attained.

  2. Coevolution of variability models and related software artifacts

    DEFF Research Database (Denmark)

    Passos, Leonardo; Teixeira, Leopoldo; Dinztner, Nicolas

    2015-01-01

    models coevolve with other artifact types, we study a large and complex real-world variant-rich software system: the Linux kernel. Specifically, we extract variability-coevolution patterns capturing changes in the variability model of the Linux kernel with subsequent changes in Makefiles and C source...

  3. Organisation Development & Industrial Relations: A Case Study.

    Science.gov (United States)

    Edmonstone, John

    1982-01-01

    In this article an account is given of work undertaken by an internal organization development (OD) unit within the United Kingdom's National Health Service, in the area of joint consultation within a health authority. Some thoughts are also presented on the relationship between OD practice and the field of industrial relations. (SSH)

  4. Inventory of environmental impact models related to energy technologies

    International Nuclear Information System (INIS)

    Owen, P.T.; Dailey, N.S.; Johnson, C.A.; Martin, F.M.

    1979-02-01

    The purpose of this inventory is to identify and collect data on computer simulations and computational models related to the environmental effects of energy source development, energy conversion, or energy utilization. Information for 33 data fields was sought for each model reported. All of the information which could be obtained within the time alloted for completion of the project is presented for each model listed. Efforts will be continued toward acquiring the needed information. Readers who are interested in these particular models are invited to contact ESIC for assistance in locating them. In addition to the standard bibliographic information, other data fields of interest to modelers, such as computer hardware and software requirements, algorithms, applications, and existing model validation information, are included. Indexes are provided for contact person, acronym, keyword, and title. The models are grouped into the following categories: atmospheric transport, air quality, aquatic transport, terrestrial food chains, soil transport, aquatic food chains, water quality, dosimetry, and human effects, animal effects, plant effects, and generalized environmental transport. Within these categories, the models are arranged alphabetically by last name of the contact person

  5. Inventory of environmental impact models related to energy technologies

    Energy Technology Data Exchange (ETDEWEB)

    Owen, P.T.; Dailey, N.S.; Johnson, C.A.; Martin, F.M. (eds.)

    1979-02-01

    The purpose of this inventory is to identify and collect data on computer simulations and computational models related to the environmental effects of energy source development, energy conversion, or energy utilization. Information for 33 data fields was sought for each model reported. All of the information which could be obtained within the time alloted for completion of the project is presented for each model listed. Efforts will be continued toward acquiring the needed information. Readers who are interested in these particular models are invited to contact ESIC for assistance in locating them. In addition to the standard bibliographic information, other data fields of interest to modelers, such as computer hardware and software requirements, algorithms, applications, and existing model validation information, are included. Indexes are provided for contact person, acronym, keyword, and title. The models are grouped into the following categories: atmospheric transport, air quality, aquatic transport, terrestrial food chains, soil transport, aquatic food chains, water quality, dosimetry, and human effects, animal effects, plant effects, and generalized environmental transport. Within these categories, the models are arranged alphabetically by last name of the contact person.

  6. Catalog of NASA-Related Case Studies

    Data.gov (United States)

    National Aeronautics and Space Administration — The OCKO has developed over 50 case studies to enhance learning at workshops, training, retreats and conferences. Case studies make mission knowledge attractive and...

  7. Relating soil geochemical properties to arsenic bioaccessibility through hierarchical modeling.

    Science.gov (United States)

    Interest in improved understanding of relationships among soil properties and arsenic (As) bioaccessibility has motivated the use of regression models for As bioaccessibility prediction. However, limits in the numbers and types of soils included in previous studies restrict the u...

  8. Soil-related Input Parameters for the Biosphere Model

    International Nuclear Information System (INIS)

    A. J. Smith

    2003-01-01

    This analysis is one of the technical reports containing documentation of the Environmental Radiation Model for Yucca Mountain Nevada (ERMYN), a biosphere model supporting the Total System Performance Assessment (TSPA) for the geologic repository at Yucca Mountain. The biosphere model is one of a series of process models supporting the Total System Performance Assessment (TSPA) for the Yucca Mountain repository. A graphical representation of the documentation hierarchy for the ERMYN biosphere model is presented in Figure 1-1. This figure shows the interrelationships among the products (i.e., analysis and model reports) developed for biosphere modeling, and the plan for development of the biosphere abstraction products for TSPA, as identified in the ''Technical Work Plan: for Biosphere Modeling and Expert Support'' (BSC 2003 [163602]). It should be noted that some documents identified in Figure 1-1 may be under development at the time this report is issued and therefore not available. This figure is included to provide an understanding of how this analysis report contributes to biosphere modeling in support of the license application, and is not intended to imply that access to the listed documents is required to understand the contents of this report. This report, ''Soil Related Input Parameters for the Biosphere Model'', is one of the five analysis reports that develop input parameters for use in the ERMYN model. This report is the source documentation for the six biosphere parameters identified in Table 1-1. ''The Biosphere Model Report'' (BSC 2003 [160699]) describes in detail the conceptual model as well as the mathematical model and its input parameters. The purpose of this analysis was to develop the biosphere model parameters needed to evaluate doses from pathways associated with the accumulation and depletion of radionuclides in the soil. These parameters support the calculation of radionuclide concentrations in soil from on-going irrigation and ash

  9. Modeling personal exposure to traffic related air pollutants

    NARCIS (Netherlands)

    Montagne, D.R.

    2015-01-01

    The first part of this thesis is about the VE3SPA project. Land use regression (LUR) models are often used to predict the outdoor air pollution at the home address of study participants, to study long-term effects of air pollution. While several studies have documented that PM2.5 mass measured at a

  10. Modeling of charged anisotropic compact stars in general relativity

    Energy Technology Data Exchange (ETDEWEB)

    Dayanandan, Baiju; Maurya, S.K.; T, Smitha T. [University of Nizwa, Department of Mathematical and Physical Sciences, College of Arts and Science, Nizwa (Oman)

    2017-06-15

    A charged compact star model has been determined for anisotropic fluid distribution. We have solved the Einstein-Maxwell field equations to construct the charged compact star model by using the radial pressure, the metric function e{sup λ} and the electric charge function. The generic charged anisotropic solution is verified by exploring different physical conditions like causality condition, mass-radius relation and stability of the solution (via the adiabatic index, TOV equations and the Herrera cracking concept). It is observed that the present charged anisotropic compact star model is compatible with the star PSR 1937+21. Moreover, we also presented the EOS ρ = f(p) for the present charged compact star model. (orig.)

  11. Studies of Catalytic Model Systems

    DEFF Research Database (Denmark)

    Holse, Christian

    of the Cu/ZnO nanoparticles is highly relevant to industrial methanol synthesis for which the direct interaction of Cu and ZnO nanocrystals synergistically boost the catalytic activity. The dynamical behavior of the nanoparticles under reducing and oxidizing environments were studied by means of ex situ X...... as the nanoparticles are reduced. The Cu/ZnO nanoparticles are tested on a  µ-reactor platform and prove to be active towards methanol synthesis, making it an excellent model system for further investigations into activity depended morphology changes....

  12. MeCP2-Related Diseases and Animal Models

    Directory of Open Access Journals (Sweden)

    Chinelo D. Ezeonwuka

    2014-01-01

    Full Text Available The role of epigenetics in human disease has become an area of increased research interest. Collaborative efforts from scientists and clinicians have led to a better understanding of the molecular mechanisms by which epigenetic regulation is involved in the pathogenesis of many human diseases. Several neurological and non-neurological disorders are associated with mutations in genes that encode for epigenetic factors. One of the most studied proteins that impacts human disease and is associated with deregulation of epigenetic processes is Methyl CpG binding protein 2 (MeCP2. MeCP2 is an epigenetic regulator that modulates gene expression by translating epigenetic DNA methylation marks into appropriate cellular responses. In order to highlight the importance of epigenetics to development and disease, we will discuss how MeCP2 emerges as a key epigenetic player in human neurodevelopmental, neurological, and non-neurological disorders. We will review our current knowledge on MeCP2-related diseases, including Rett Syndrome, Angelman Syndrome, Fetal Alcohol Spectrum Disorder, Hirschsprung disease, and Cancer. Additionally, we will briefly discuss about the existing MeCP2 animal models that have been generated for a better understanding of how MeCP2 impacts certain human diseases.

  13. How is weight stigma related to children's health-related quality of life? A model comparison approach.

    Science.gov (United States)

    Guardabassi, Veronica; Mirisola, Alberto; Tomasetto, Carlo

    2018-01-01

    Obesity is a highly stigmatizing condition for both adults and children, and both obesity and stigma experiences are negatively related with health-related quality of life (HRQoL). However, the relations among these constructs have been modeled in different and sometimes inconsistent terms in past research, and have been the object of surprisingly few studies in pediatric populations. The present study addresses this gap by comparing, in a sample of preadolescent children, four competing models (i.e., additive, mediation, moderation, and moderated mediation models) accounting for the role of stigma experiences in the concurrent relation between body weight and HRQoL. A community sample of 600 children aged 8-11 years completed the Perception of Teasing Scale to assess weight-based teasing experiences and the PedsQL 4.0 to assess HRQoL. Parent-reported height and weight were used to calculate age- and gender-adjusted zBMI. Log-likelihood test, BIC difference, and Wald test were used for model comparisons. The mediation model outperformed both additive and moderation models and was found to be equally informative (but more parsimonious) as compared to the moderated mediation account. The same pattern of results was replicated for both global HRQoL and domain-specific quality of life domains (i.e., physical, emotional, social, and scholastic). The mediation model provided the best fitting and more parsimonious representation of the relations between body weight, stigma experiences, and HRQoL, meaning that an increased likelihood of experiencing weight-based teasing episodes, rather than excess weight per se, is associated with reduced quality of life in middle childhood.

  14. Power-plant-related estuarine zooplankton studies

    International Nuclear Information System (INIS)

    Sage, L.E.; Olson, M.M.

    1981-01-01

    In-plant studies examining the effects of entrainment on zooplankton and field studies examining zooplankton abundance, composition, and distribution in the Chesapeake Bay in the vicinity of Calvert Cliffs Nuclear Power Plant have been conducted from 1974 to the present. The evolution of these studies, with particular emphasis on design and statistical treatment, is discussed. Entrainment study designs evolved from discrete sampling episodes at 4-h intervals over 24 h to a time-series sampling design in which sampling took place every 30 min over 24 and 48-h periods. The near-field study design and samping methods have included replicated net tows, using 0.5-m nets, and replicated and nonreplicated pumped sampling, using a high-speed centrifugal pump. 16 refs

  15. Epistemology and Rosen's Modeling Relation

    Energy Technology Data Exchange (ETDEWEB)

    Dress, W.B.

    1999-11-07

    Rosen's modeling relation is embedded in Popper's three worlds to provide an heuristic tool for model building and a guide for thinking about complex systems. The utility of this construct is demonstrated by suggesting a solution to the problem of pseudo science and a resolution of the famous Bohr-Einstein debates. A theory of bizarre systems is presented by an analogy with entangled particles of quantum mechanics. This theory underscores the poverty of present-day computational systems (e.g., computers) for creating complex and bizarre entities by distinguishing between mechanism and organism.

  16. On autostability of almost prime models relative to strong constructivizations

    International Nuclear Information System (INIS)

    Goncharov, Sergey S

    2011-01-01

    Questions of autostability and algorithmic dimension of models go back to papers by A.I. Malcev and by A. Froehlich and J.C. Shepherdson in which the effect of the existence of computable presentations which are non-equivalent from the viewpoint of their algorithmic properties was first discovered. Today there are many papers by various authors devoted to investigations of such questions. The present paper deals with the question of inheritance of the properties of autostability and non-autostability relative to strong constructivizations under elementary extensions for almost prime models. Bibliography: 37 titles.

  17. Social relations and PTSD symptoms: a prospective study on earthquake-impacted adolescents in Taiwan.

    Science.gov (United States)

    Wu, Chih-Hsun; Chen, Sue-Huei; Weng, Li-Jen; Wu, Yin-Chang

    2009-10-01

    This prospective longitudinal study examined two competing models, a traditional social support model and a supportive and detrimental social relations model, to clarify the association of PTSD symptoms with supportive and detrimental social relations. Seven-hundred five adolescents living near the epicenter of the Taiwan Chi-Chi Earthquake participated in the study. The models were evaluated and cross-validated using structural equation modeling. The supportive and detrimental social relations model appeared to be a better fit. After further evaluation of three nested versions of the supportive and detrimental social relations model, detrimental social relations was found to partially mediate the relationship between PTSD symptoms 1 and 2 years following the earthquake. The findings suggest that helping adolescents deal with detrimental social relations can contribute to postdisaster adjustment.

  18. Congenital Rubella: Clinical and Related Studies

    Science.gov (United States)

    Menser, Margaret A.

    1977-01-01

    Briefly described are four studies currently being undertaken in Australia to determine the effectiveness of vaccination in the prevention of rubella and to examine the relationship between rubella and diabetes. (CL)

  19. Mathematical model II. Basic particle and special relativity

    Directory of Open Access Journals (Sweden)

    Nitin Ramchandra Gadre

    2011-03-01

    Full Text Available The basic particle electron obeys various theories like electrodynamics, quantum mechanics and special relativity. Particle under different experimental conditions behaves differently, allowing us to observe different characteristics which become basis for these theories. In this paper, we try to find out the requirements of the special relativity and suggest a mathematical particle model which can satisfy these requirements. The basic presumption is that the particle should have some structural characteristics which make the particle obey the postulates of these theories. As it is experimentally ‘difficult’ to find the structure of basic particle electron we make a mathematical attempt. We call this model as logically and mathematically probable structure of the basic particle, electron.

  20. INTERGROUP RELATIONS IN SOCIAL-STUDIES TEXTBOOKS.

    Science.gov (United States)

    HARRIS, JUDAH J.

    RESULTS OF SURVEYS OF SOCIAL STUDIES TEXTBOOKS USED IN PUBLIC ELEMENTARY AND SECONDARY SCHOOLS AND PAROCHIAL SCHOOLS ARE PRESENTED. IN SECONDARY TEXTBOOKS, FOCUS WAS ON THE ATTENTION GIVEN TO THE TREATMENT OF JOBS, OF AMERICAN NEGROES, OF IMMIGRANTS, AND OF MINORITIES UNDER NAZISM. IT WAS FOUND THAT (1) ANCIENT HEBREW HISTORY, TO THE EXCLUSION OF…

  1. Analytical study of anisotropic compact star models

    Science.gov (United States)

    Ivanov, B. V.

    2017-11-01

    A simple classification is given of the anisotropic relativistic star models, resembling the one of charged isotropic solutions. On the ground of this database, and taking into account the conditions for physically realistic star models, a method is proposed for generating all such solutions. It is based on the energy density and the radial pressure as seeding functions. Numerous relations between the realistic conditions are found and the need for a graphic proof is reduced just to one pair of inequalities. This general formalism is illustrated with an example of a class of solutions with linear equation of state and simple energy density. It is found that the solutions depend on three free constants and concrete examples are given. Some other popular models are studied with the same method.

  2. Analytical study of anisotropic compact star models

    Energy Technology Data Exchange (ETDEWEB)

    Ivanov, B.V. [Bulgarian Academy of Science, Institute for Nuclear Research and Nuclear Energy, Sofia (Bulgaria)

    2017-11-15

    A simple classification is given of the anisotropic relativistic star models, resembling the one of charged isotropic solutions. On the ground of this database, and taking into account the conditions for physically realistic star models, a method is proposed for generating all such solutions. It is based on the energy density and the radial pressure as seeding functions. Numerous relations between the realistic conditions are found and the need for a graphic proof is reduced just to one pair of inequalities. This general formalism is illustrated with an example of a class of solutions with linear equation of state and simple energy density. It is found that the solutions depend on three free constants and concrete examples are given. Some other popular models are studied with the same method. (orig.)

  3. Parameters-related uncertainty in modeling sugar cane yield with an agro-Land Surface Model

    Science.gov (United States)

    Valade, A.; Ciais, P.; Vuichard, N.; Viovy, N.; Ruget, F.; Gabrielle, B.

    2012-12-01

    Agro-Land Surface Models (agro-LSM) have been developed from the coupling of specific crop models and large-scale generic vegetation models. They aim at accounting for the spatial distribution and variability of energy, water and carbon fluxes within soil-vegetation-atmosphere continuum with a particular emphasis on how crop phenology and agricultural management practice influence the turbulent fluxes exchanged with the atmosphere, and the underlying water and carbon pools. A part of the uncertainty in these models is related to the many parameters included in the models' equations. In this study, we quantify the parameter-based uncertainty in the simulation of sugar cane biomass production with the agro-LSM ORCHIDEE-STICS on a multi-regional approach with data from sites in Australia, La Reunion and Brazil. First, the main source of uncertainty for the output variables NPP, GPP, and sensible heat flux (SH) is determined through a screening of the main parameters of the model on a multi-site basis leading to the selection of a subset of most sensitive parameters causing most of the uncertainty. In a second step, a sensitivity analysis is carried out on the parameters selected from the screening analysis at a regional scale. For this, a Monte-Carlo sampling method associated with the calculation of Partial Ranked Correlation Coefficients is used. First, we quantify the sensitivity of the output variables to individual input parameters on a regional scale for two regions of intensive sugar cane cultivation in Australia and Brazil. Then, we quantify the overall uncertainty in the simulation's outputs propagated from the uncertainty in the input parameters. Seven parameters are identified by the screening procedure as driving most of the uncertainty in the agro-LSM ORCHIDEE-STICS model output at all sites. These parameters control photosynthesis (optimal temperature of photosynthesis, optimal carboxylation rate), radiation interception (extinction coefficient), root

  4. Semiotic aspects of control and modeling relations in complex systems

    Energy Technology Data Exchange (ETDEWEB)

    Joslyn, C.

    1996-08-01

    A conceptual analysis of the semiotic nature of control is provided with the goal of elucidating its nature in complex systems. Control is identified as a canonical form of semiotic relation of a system to its environment. As a form of constraint between a system and its environment, its necessary and sufficient conditions are established, and the stabilities resulting from control are distinguished from other forms of stability. These result from the presence of semantic coding relations, and thus the class of control systems is hypothesized to be equivalent to that of semiotic systems. Control systems are contrasted with models, which, while they have the same measurement functions as control systems, do not necessarily require semantic relations because of the lack of the requirement of an interpreter. A hybrid construction of models in control systems is detailed. Towards the goal of considering the nature of control in complex systems, the possible relations among collections of control systems are considered. Powers arguments on conflict among control systems and the possible nature of control in social systems are reviewed, and reconsidered based on our observations about hierarchical control. Finally, we discuss the necessary semantic functions which must be present in complex systems for control in this sense to be present at all.

  5. LHC related projects and studies - Part (I)

    International Nuclear Information System (INIS)

    Garoby, R.; Ponce, L.

    2012-01-01

    This session was the first of the two sessions dealing with future projects and the associated studies. Starting with descriptions of the plans and needs of the LHCb and ALICE experiments which are less extensively documented than those of ATLAS and CMS, it addressed the plans for the High Luminosity LHC and for the upgrade of the injectors, both for protons and other ions. (authors)

  6. Testing a Relational Model for Health Communication Competence among Caregivers for Individuals with Alzheimer's Disease.

    Science.gov (United States)

    Query, J L; Kreps, G L

    1996-07-01

    The Relational Model of Health Communication Competence suggests that health-care participants' level of communication competence is positively related to their achieving desired physiological and psychological health outcomes. This article provides a partial test of the model by examining the relationships between communication competence, social support and cognitive depression among lay caregivers of patients with Alzheimer's disease. The study provides validation for the model by demonstrating that the communication competence of the caregivers is positively related to important psychological health outcomes, such as high levels of social support, and decreases in cognitive depression. Implications of these findings and directions for future inquiry are examined.

  7. Mathematical model for research and analyze relations and functions between enterprises, members of cluster

    Science.gov (United States)

    Angelov, Kiril; Kaynakchieva, Vesela

    2017-12-01

    The aim of the current study is to research and analyze Mathematical model for research and analyze of relations and functions between enterprises, members of cluster, and its approbation in given cluster. Subject of the study are theoretical mechanisms for the definition of mathematical models for research and analyze of relations and functions between enterprises, members of cluster. Object of the study are production enterprises, members of cluster. Results of this study show that described theoretical mathematical model is applicable for research and analyze of functions and relations between enterprises, members of cluster from different industrial sectors. This circumstance creates alternatives for election of cluster, where is experimented this model for interaction improvement between enterprises, members of cluster.

  8. Relational event models for longitudinal network data with an application to interhospital patient transfers.

    Science.gov (United States)

    Vu, Duy; Lomi, Alessandro; Mascia, Daniele; Pallotti, Francesca

    2017-06-30

    The main objective of this paper is to introduce and illustrate relational event models, a new class of statistical models for the analysis of time-stamped data with complex temporal and relational dependencies. We outline the main differences between recently proposed relational event models and more conventional network models based on the graph-theoretic formalism typically adopted in empirical studies of social networks. Our main contribution involves the definition and implementation of a marked point process extension of currently available models. According to this approach, the sequence of events of interest is decomposed into two components: (a) event time and (b) event destination. This decomposition transforms the problem of selection of event destination in relational event models into a conditional multinomial logistic regression problem. The main advantages of this formulation are the possibility of controlling for the effect of event-specific data and a significant reduction in the estimation time of currently available relational event models. We demonstrate the empirical value of the model in an analysis of interhospital patient transfers within a regional community of health care organizations. We conclude with a discussion of how the models we presented help to overcome some the limitations of statistical models for networks that are currently available. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  9. A modified microdosimetric kinetic model for relative biological effectiveness calculation

    Science.gov (United States)

    Chen, Yizheng; Li, Junli; Li, Chunyan; Qiu, Rui; Wu, Zhen

    2018-01-01

    In the heavy ion therapy, not only the distribution of physical absorbed dose, but also the relative biological effectiveness (RBE) weighted dose needs to be taken into account. The microdosimetric kinetic model (MKM) can predict the RBE value of heavy ions with saturation-corrected dose-mean specific energy, which has been used in clinical treatment planning at the National Institute of Radiological Sciences. In the theoretical assumption of the MKM, the yield of the primary lesion is independent of the radiation quality, while the experimental data shows that DNA double strand break (DSB) yield, considered as the main primary lesion, depends on the LET of the particle. Besides, the β parameter of the MKM is constant with LET resulting from this assumption, which also differs from the experimental conclusion. In this study, a modified MKM was developed, named MMKM. Based on the experimental DSB yield of mammalian cells under the irradiation of ions with different LETs, a RBEDSB (RBE for the induction of DSB)-LET curve was fitted as the correction factor to modify the primary lesion yield in the MKM, and the variation of the primary lesion yield with LET is considered in the MMKM. Compared with the present the MKM, not only the α parameter of the MMKM for mono-energetic ions agree with the experimental data, but also the β parameter varies with LET and the variation trend of the experimental result can be reproduced on the whole. Then a spread-out Bragg peaks (SOBP) distribution of physical dose was simulated with Geant4 Monte Carlo code, and the biological and clinical dose distributions were calculated, under the irradiation of carbon ions. The results show that the distribution of clinical dose calculated with the MMKM is closed to the distribution with the MKM in the SOBP, while the discrepancy before and after the SOBP are both within 10%. Moreover, the MKM might overestimate the clinical dose at the distal end of the SOBP more than 5% because of its

  10. Shapes related to longitudinal studies of disease

    DEFF Research Database (Denmark)

    Erleben, Lene Lillemark

    investigated four different proximity markers which lead to significantly improved marker values between NC and AD after correction for whole brain and hippocampus volume. Based on the different proximity markers we have chosen the surface connectivity marker that gave the best separation to investigate......This dissertation investigates novel markers for cardiovascular diseases (CVD) and Alzheimer's disease (AD). Both CVD and AD are among the large diseases counted in morbidity and mortality in the western world, which makes them huge and increasing problems. By investigating and learning....... The first part of this dissertation studies the growth patterns of atherosclerotic calcified deposits in the lumbar aorta based on x-ray images over an 8-year time period. We have been able to find simple growth patterns that explain how the calcifications evolve. The calcifications grew on average 41 % (p...

  11. School Board Improvement Plans in Relation to the AIP Model of Educational Accountability: A Content Analysis

    Science.gov (United States)

    van Barneveld, Christina; Stienstra, Wendy; Stewart, Sandra

    2006-01-01

    For this study we analyzed the content of school board improvement plans in relation to the Achievement-Indicators-Policy (AIP) model of educational accountability (Nagy, Demeris, & van Barneveld, 2000). We identified areas of congruence and incongruence between the plans and the model. Results suggested that the content of the improvement…

  12. Teriparatide and the treatment of bisphosphonate-related osteonecrosis of the jaw: a rat model

    NARCIS (Netherlands)

    Ersan, N.; van Ruijven, L.J.; Bronckers, A.L.J.J.; Olgaç, V.; Ìlgüy, D.; Everts, V.

    2014-01-01

    Objectives: The objectives of this study were to establish a bisphosphonate-related osteonecrosis of the jaw (BRONJ) rat model and to analyse the effects of teriparatide (TP) on this model. Methods: Sprague-Dawley rats were divided into three groups: I—zoledronic acid (ZA, n = 10); II—ZA and

  13. Relating soil geochemical properties to arsenic bioaccessibility through hierarchical modeling.

    Science.gov (United States)

    Nelson, Clay M; Li, Kevin; Obenour, Daniel R; Miller, Jonathan; Misenheimer, John C; Scheckel, Kirk; Betts, Aaron; Juhasz, Albert; Thomas, David J; Bradham, Karen D

    2018-01-01

    Interest in improved understanding of relationships among soil properties and arsenic (As) bioaccessibility has motivated the use of regression models for As bioaccessibility prediction. However, limits in the numbers and types of soils included in previous studies restrict the usefulness of these models beyond the range of soil conditions evaluated, as evidenced by reduced predictive performance when applied to new data. In response, hierarchical models that consider variability in relationships among soil properties and As bioaccessibility across geographic locations and contaminant sources were developed to predict As bioaccessibility in 139 soils on both a mass fraction (mg/kg) and % basis. The hierarchical approach improved the estimation of As bioaccessibility in studied soils. In addition, the number of soil elements identified as statistically significant explanatory variables increased when compared to previous investigations. Specifically, total soil Fe, P, Ca, Co, and V were significant explanatory variables in both models, while total As, Cd, Cu, Ni, and Zn were also significant in the mass fraction model and Mg was significant in the % model. This developed hierarchical approach provides a novel tool to (1) explore relationships between soil properties and As bioaccessibility across a broad range of soil types and As contaminant sources encountered in the environment and (2) identify areas of future mechanistic research to better understand the complexity of interactions between soil properties and As bioaccessibility.

  14. Translational Models of Gambling-Related Decision-Making.

    Science.gov (United States)

    Winstanley, Catharine A; Clark, Luke

    Gambling is a harmless, recreational pastime that is ubiquitous across cultures. However, for some, gambling becomes a maladaptive and compulsive, and this syndrome is conceptualized as a behavioural addiction. Laboratory models that capture the key cognitive processes involved in gambling behaviour, and that can be translated across species, have the potential to make an important contribution to both decision neuroscience and the study of addictive disorders. The Iowa gambling task has been widely used to assess human decision-making under uncertainty, and this paradigm can be successfully modelled in rodents. Similar neurobiological processes underpin choice behaviour in humans and rats, and thus, a preference for the disadvantageous "high-risk, high-reward" options may reflect meaningful vulnerability for mental health problems. However, the choice behaviour operationalized by these tasks does not necessarily approximate the vulnerability to gambling disorder (GD) per se. We consider a number of psychological challenges that apply to modelling gambling in a translational way, and evaluate the success of the existing models. Heterogeneity in the structure of gambling games, as well as in the motivations of individuals with GD, is highlighted. The potential issues with extrapolating too directly from established animal models of drug dependency are discussed, as are the inherent difficulties in validating animal models of GD in the absence of any approved treatments for GD. Further advances in modelling the cognitive biases endemic in human decision-making, which appear to be exacerbated in GD, may be a promising line of research.

  15. A CONSOLIDATED MODEL OF ANALYSIS OF THE RELATIONS BETWEEN POLITICS AND MANAGEMENT WITHIN PUBLIC ORGANIZATIONS

    OpenAIRE

    Catalina Maria GEORGESCU; Tudor NISTORESCU

    2011-01-01

    An interdisciplinary approach which combines the theoretical, empirical and conceptual dimensions, the present study tries to offer a new work perspective on the assessment and modeling of the relation between the management of public organizations and the political environment. The theoretical research was centered on reviewing the literature on the relation between the management of public organizations and the political environment. The empirical research was materialized by modeling with ...

  16. Crystal study and econometric model

    Science.gov (United States)

    1975-01-01

    An econometric model was developed that can be used to predict demand and supply figures for crystals over a time horizon roughly concurrent with that of NASA's Space Shuttle Program - that is, 1975 through 1990. The model includes an equation to predict the impact on investment in the crystal-growing industry. Actually, two models are presented. The first is a theoretical model which follows rather strictly the standard theoretical economic concepts involved in supply and demand analysis, and a modified version of the model was developed which, though not quite as theoretically sound, was testable utilizing existing data sources.

  17. Reciprocal Relations Between Cognitive Neuroscience and Cognitive Models: Opposites Attract?

    Science.gov (United States)

    Forstmann, Birte U.; Wagenmakers, Eric-Jan; Eichele, Tom; Brown, Scott; Serences, John T.

    2012-01-01

    Cognitive neuroscientists study how the brain implements particular cognitive processes such as perception, learning, and decision-making. Traditional approaches in which experiments are designed to target a specific cognitive process have been supplemented by two recent innovations. First, formal models of cognition can decompose observed behavioral data into multiple latent cognitive processes, allowing brain measurements to be associated with a particular cognitive process more precisely and more confidently. Second, cognitive neuroscience can provide additional data to inform the development of cognitive models, providing greater constraint than behavioral data alone. We argue that these fields are mutually dependent: not only can models guide neuroscientific endeavors, but understanding neural mechanisms can provide critical insights into formal models of cognition. PMID:21612972

  18. Immunological studies relating to the climate

    International Nuclear Information System (INIS)

    Ballester, J.M.; Cruz, C.; Inclan, G.; Maclas, C.; Suarez, L.; Rivero, R.; Borres, I.M.; Ustariz, C.; Del Valle, L.; Villegas, R.; Martinez, E.; Rorrajero, I.; Guevara, V.; Leon, A.; Paz, L.; Pelaez, J.C.; Roque, M.C.

    1993-01-01

    In order to know the effects of ultra-violet radiations on the integrity of their immunological system, a hematologic and immunological study was carried out in 30 clinically healthy children aged between 10 and 15; 15 of each sex, who come from a region in Bielorussia that was affected by the Chernobyl nuclear accident, and who received medical and recreational services at the 'Jose Marti' Pioneers'City, located Tarara Beach (Havana, Cuba) from July 9,1990 to August 27,1990. Data from the initial evaluations upon their arrival in Cuba were compared whit the final results before their return to Bielorussia, in the following variables: haemoglobin, leucocytes, platelets, absolute counts of lymphocytes and neutrophylous polymorphonuclears, levels of sericeus of Igs G, A, M, and E sericas and (CH50), as well as the presence of circulating immuno complexes; besides spot-forming cellular clusters (spontaneous, active, and medial by the receptor Fc in neutrophylous) and the cells identified with monoclonal antibodies against CD2, CD3, CD8 and CD4/CD8 quotient. Cutaneous response to antigen and lymphoblastic transformation in the presence of PHA and PwN were also assessed. Results of this research allow to infer that the adequate and monitored position against ultra-violet rays from the solar radiation in children exposed to low doses of ionizing irradiation does not deteriorate the human immunological system, and do favor its regulation and normal performance

  19. Models of political public relations: Testing the situation in Catalonia

    Directory of Open Access Journals (Sweden)

    Dr. Jordi Xifra Triadú

    2008-01-01

    Full Text Available The idea that political communication strategies are an application of marketing strategies to political field is today commonly shared by specialists. For them public relations is viewed like a set of techniques that serves political parties and other actors of the political scene, concentrated on media relations. This instrumental perspective is not in keeping with structural dimension of public relations in political activity and communication of his actors: political parties, pressure groups and political leaders. In this point of view, during managing periods of governance or opposition and during electoral campaigns, the most applied communication form by political parties is structured in accordance with the major public relations models: press agent model, public information model, two way asymmetrical model, and two way symmetrical model. This research prove hypothesis in Catalonia according the results of a quantitative survey focused on inside professionals who provide services for the seven main political parties in this Spanish Autonomous Community.RESUMEN:La idea de que las estrategias de comunicación política constituyen una aplicación de las estrategias del marketing al ámbito político es hoy comúnmente compartida por los analistas. Para éstos, las relaciones públicas son percibidas como un conjunto de técnicas al servicio de los partidos políticos y de otros actores de la escena política concentradas en las relaciones con la prensa. Esta perspectiva instrumental no concuerda con la dimensión estructural de las relaciones públicas en la actividad política y comunicativa de sus actores: partidos políticos, grupos de presión y líderes. Desde este punto de vista, tanto en los periodos de gestión u oposición como en los electorales, la forma comunicativa más aplicada por los partidos políticos se estructura de acuerdo con los modelos tradicionales de las relaciones públicas: agente de prensa, información p

  20. Relational Aggression in Women during Emerging Adulthood: A Social Process Model.

    Science.gov (United States)

    Ostrov, Jamie M; Hart, Emily J; Kamper, Kimberly E; Godleski, Stephanie A

    2011-01-01

    Two studies investigated potential mediators of the association between relational victimization and relational aggression. Self-report measures of aggressive behavior among peers, exclusivity, hostile attribution biases, and borderline personality disorder (BPD) symptoms were collected. In study 1, participants were 180 female emerging adults (M = 18.82, SD = 1.18). Both exclusivity and hostile attribution biases for relational provocations were found to partially mediate the association between relational victimization and relational aggression. In study 2, participants were 54 female emerging adults (M = 19.16, SD = 1.11). Symptoms of BPD were not found to mediate the association between relational victimization and relational aggression, yet unique associations with relational aggression were observed. The results add to recent research guided by a social process model in which links between victimization and aggression are more clearly understood. Copyright © 2011 John Wiley & Sons, Ltd.

  1. Additive gamma frailty models with applications to competing risks in related individuals

    DEFF Research Database (Denmark)

    Eriksson, Frank; Scheike, Thomas

    2015-01-01

    Epidemiological studies of related individuals are often complicated by the fact that follow-up on the event type of interest is incomplete due to the occurrence of other events. We suggest a class of frailty models with cause-specific hazards for correlated competing events in related individual...

  2. Soil-Related Input Parameters for the Biosphere Model

    International Nuclear Information System (INIS)

    Smith, A. J.

    2004-01-01

    This report presents one of the analyses that support the Environmental Radiation Model for Yucca Mountain Nevada (ERMYN). The ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) describes the details of the conceptual model as well as the mathematical model and the required input parameters. The biosphere model is one of a series of process models supporting the postclosure Total System Performance Assessment (TSPA) for the Yucca Mountain repository. A schematic representation of the documentation flow for the Biosphere input to TSPA is presented in Figure 1-1. This figure shows the evolutionary relationships among the products (i.e., analysis and model reports) developed for biosphere modeling, and the biosphere abstraction products for TSPA, as identified in the ''Technical Work Plan for Biosphere Modeling and Expert Support'' (TWP) (BSC 2004 [DIRS 169573]). This figure is included to provide an understanding of how this analysis report contributes to biosphere modeling in support of the license application, and is not intended to imply that access to the listed documents is required to understand the contents of this report. This report, ''Soil-Related Input Parameters for the Biosphere Model'', is one of the five analysis reports that develop input parameters for use in the ERMYN model. This report is the source documentation for the six biosphere parameters identified in Table 1-1. The purpose of this analysis was to develop the biosphere model parameters associated with the accumulation and depletion of radionuclides in the soil. These parameters support the calculation of radionuclide concentrations in soil from on-going irrigation or ash deposition and, as a direct consequence, radionuclide concentration in other environmental media that are affected by radionuclide concentrations in soil. The analysis was performed in accordance with the TWP (BSC 2004 [DIRS 169573]) where the governing procedure was defined as AP-SIII.9Q, ''Scientific Analyses''. This

  3. Soil-Related Input Parameters for the Biosphere Model

    Energy Technology Data Exchange (ETDEWEB)

    A. J. Smith

    2004-09-09

    This report presents one of the analyses that support the Environmental Radiation Model for Yucca Mountain Nevada (ERMYN). The ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) describes the details of the conceptual model as well as the mathematical model and the required input parameters. The biosphere model is one of a series of process models supporting the postclosure Total System Performance Assessment (TSPA) for the Yucca Mountain repository. A schematic representation of the documentation flow for the Biosphere input to TSPA is presented in Figure 1-1. This figure shows the evolutionary relationships among the products (i.e., analysis and model reports) developed for biosphere modeling, and the biosphere abstraction products for TSPA, as identified in the ''Technical Work Plan for Biosphere Modeling and Expert Support'' (TWP) (BSC 2004 [DIRS 169573]). This figure is included to provide an understanding of how this analysis report contributes to biosphere modeling in support of the license application, and is not intended to imply that access to the listed documents is required to understand the contents of this report. This report, ''Soil-Related Input Parameters for the Biosphere Model'', is one of the five analysis reports that develop input parameters for use in the ERMYN model. This report is the source documentation for the six biosphere parameters identified in Table 1-1. The purpose of this analysis was to develop the biosphere model parameters associated with the accumulation and depletion of radionuclides in the soil. These parameters support the calculation of radionuclide concentrations in soil from on-going irrigation or ash deposition and, as a direct consequence, radionuclide concentration in other environmental media that are affected by radionuclide concentrations in soil. The analysis was performed in accordance with the TWP (BSC 2004 [DIRS 169573]) where the governing procedure

  4. Surface studies of titania related nanostructures

    Science.gov (United States)

    Papageorgiou, Anthoula Chrysa

    In this thesis, surface sensitive techniques have been employed to investigate the surface chemistry of TiC>2. A bottom-up approach was used to grow ultra-thin films of rutile TiO2(110) on Ni(110). The surface structure of this system was probed using scanning tunnelling microscopy (STM) and low energy electron diffraction (LEED), whereas the electronic structure was characterised with soft X-ray photoelectron spectroscopy (SXPS). SXPS was also used to investigate the reactivity of this system towards water. While optimising the conditions for the growth of the desired titania phase, the growth of other structures commonly found in reduced native TiC>2 crystals were apparent from STM and LEED observations. The formation of 1x2 reconstructed TiO2(110) and crystallographic shear planes are reported. These phases are assigned by comparison with previous studies of analogous phases on the native rutile TiC>2(110) surface. STM was also used to monitor chemical reactions on native TiO2(110) surfaces. The reaction of surface bridging hydroxyl groups with molecular oxygen at room temperature was imaged directly. After exposure to O2, nearly all bridging hydroxyl groups are consumed, and new, mobile adsorbates appear with a range of apparent heights. With the support of calculations performed by Hofer's group in the University of Liverpool and Fisher's group in UCL, the adsorbates left on the surface after the reaction are assigned to neutral and charged oxygen adatoms as well as terminal hydroxyls. Finally, the surface local density of states of TiO2(110) were measured using scanning tunnelling spectroscopy. Energetically localised states are found at sample biases of +0.2 V, 0.7 V and 1.9 V. Additionally, a surface state at 1.9 V is localised spatially at two adjacent titanium five-fold atoms near to the positions of surface oxygen vacancies.

  5. Pharmacodynamic Modelling of Placebo and Buprenorphine Effects on Event-Related Potentials in Experimental Pain

    DEFF Research Database (Denmark)

    Juul, Rasmus V; Foster, David J R; Upton, Richard N

    2014-01-01

    The purpose of the study was to investigate placebo and buprenorphine effects on event-related potentials (ERPs) in experimental pain and the potential benefit of population pharmacodynamic modelling in data analysis. Nineteen healthy volunteers received transdermal placebo and buprenorphine...... in a cross-over study. Drug plasma concentrations and ERPs after electrical stimulation at the median nerve with intensity adjusted to pain detection threshold were recorded until 144 hrs after administration. Placebo and concentration-effect models were fitted to data using non-linear mixed-effects...... modelling implemented in NONMEM (V7.2.0.). Pharmacodynamic models were developed to adequately describe both placebo and buprenorphine ERP data. Models predicted significant placebo effects, but did not predict significant effects related to buprenorphine concentration. Models revealed that ERPs varied both...

  6. Systemic Modelling for Relating Labour Market to Vocational Education

    Science.gov (United States)

    Papakitsos, Evangelos C.

    2016-01-01

    The present study introduces a systemic model that demonstrates a description of the relationship between the labour-market and vocational education from the perspective of systemic theory. Based on the application of the relevant methodology, the two open social systems are identified and analyzed. Their key-features are presented and the points…

  7. Relations among stress, coping strategies, coping motives, alcohol consumption and related problems: a mediated moderation model.

    Science.gov (United States)

    Corbin, William R; Farmer, Nicole M; Nolen-Hoekesma, Susan

    2013-04-01

    Although prominent models of alcohol use and abuse implicate stress as an important motivator of alcohol consumption, research has not consistently identified a relationship between stress and drinking outcomes. Presumably stress leads to heavier alcohol consumption and related problems primarily for individuals who lack other adaptive methods for coping effectively with stressful experiences. To test this hypothesis, we examined four adaptive coping approaches (active coping, planning, suppression of competing activities, and restraint), as predictors of alcohol use and related problems as well as moderators of relations between stress and drinking outcomes in an undergraduate population (N=225). Further, we examined coping motives for drinking as potential mediators of the effects of coping strategies as well as stress by coping strategy interactions. Analyses supported both restraint and suppression of competing activities as moderators of the influence of stress on alcohol use but not problems. The stress by restraint interaction was also evident in the prediction of coping motives, and coping motives were related to higher levels of both weekly drinking and alcohol-related problems. Finally, coping motives for drinking served to mediate the stress by restraint interaction on weekly drinking. Overall, these results suggest that efforts to suppress competing activities and restrain impulsive responses in the face of stress may reduce the risk for heavy drinking during the transition from high school to college. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Relative sensitivity analysis of the predictive properties of sloppy models.

    Science.gov (United States)

    Myasnikova, Ekaterina; Spirov, Alexander

    2018-01-25

    Commonly among the model parameters characterizing complex biological systems are those that do not significantly influence the quality of the fit to experimental data, so-called "sloppy" parameters. The sloppiness can be mathematically expressed through saturating response functions (Hill's, sigmoid) thereby embodying biological mechanisms responsible for the system robustness to external perturbations. However, if a sloppy model is used for the prediction of the system behavior at the altered input (e.g. knock out mutations, natural expression variability), it may demonstrate the poor predictive power due to the ambiguity in the parameter estimates. We introduce a method of the predictive power evaluation under the parameter estimation uncertainty, Relative Sensitivity Analysis. The prediction problem is addressed in the context of gene circuit models describing the dynamics of segmentation gene expression in Drosophila embryo. Gene regulation in these models is introduced by a saturating sigmoid function of the concentrations of the regulatory gene products. We show how our approach can be applied to characterize the essential difference between the sensitivity properties of robust and non-robust solutions and select among the existing solutions those providing the correct system behavior at any reasonable input. In general, the method allows to uncover the sources of incorrect predictions and proposes the way to overcome the estimation uncertainties.

  9. Analytical model of stemwood growth in relation to nitrogen supply

    Energy Technology Data Exchange (ETDEWEB)

    Dewar, R. C.; McMurtrie, R. E. [New South Wales Univ., Sydney, NSW (Australia)

    1996-01-01

    A process-based model of tree stand growth that simulates the effect of nitrogen supply on forest productivity has been recently combined with a soil-carbon-nitrogen model. The combined model, called G`DAY has been used to examine the long-term response of unmanaged forest ecosystems to increasing CO{sub 2} concentration. In this study an attempt was made to derive a simplified, analytically tractable version of the plant production part of G`DAY, and use it to gain insight into the general relationship between stemwood growth and nitrogen supply in managed forests. The particular focus of the study was on using the model to predict how the maximum annual stemwood growth and optimal rotation length can be expected to vary in response to changes in nitrogen supply from net mineralization, fertilizer addition, fixation and atmospheric deposition. Overall, the model was considered to be a useful tool in examining the effects of changes in climate and nutrient supply on sustainable forest productivity. 20 refs., 2 tabs., 5 figs.

  10. A linearized dispersion relation for orthorhombic pseudo-acoustic modeling

    KAUST Repository

    Song, Xiaolei

    2012-11-04

    Wavefield extrapolation in acoustic orthorhombic anisotropic media suffers from wave-mode coupling and stability limitations in the parameter range. We introduce a linearized form of the dispersion relation for acoustic orthorhombic media to model acoustic wavefields. We apply the lowrank approximation approach to handle the corresponding space-wavenumber mixed-domain operator. Numerical experiments show that the proposed wavefield extrapolator is accurate and practically free of dispersions. Further, there is no coupling of qSv and qP waves, because we use the analytical dispersion relation. No constraints on Thomsen\\'s parameters are required for stability. The linearized expression may provide useful application for parameter estimation in orthorhombic media.

  11. Morphometric relations of fractal-skeletal based channel network model

    Directory of Open Access Journals (Sweden)

    B. S. Daya Sagar

    1998-01-01

    Full Text Available A fractal-skeletal based channel network (F-SCN model is proposed. Four regular sided initiator-basins are transformed as second order fractal basins by following a specific generating mechanism with non-random rule. The morphological skeletons, hereafter referred to as channel networks, are extracted from these fractal basins. The morphometric and fractal relationships of these F-SCNs are shown. The fractal dimensions of these fractal basins, channel networks, and main channel lengths (computed through box counting method are compared with those of estimated length–area measures. Certain morphometric order ratios to show fractal relations are also highlighted.

  12. What a public-relations-model regarding radioactive waste implicates

    Energy Technology Data Exchange (ETDEWEB)

    Ohnishi, Teruaki [CRC Research Institute, Inc., Tokyo (Japan)]|[Energy Research Center Wakasa Bay, Fukui (Japan)

    1996-12-31

    The behavior of public attitude to radioactive waste with time was investigated by using a mathematical model which was developed for estimating the extent of attitude change, being based on the assumption that the change of public attitude to a certain subject is caused by the information environment mainly formed by the newsmedia. Investigations were also made on the extent the public relations activity can contribute to the change of public opinion for the radioactive waste, and on the method of assortment and execution of various types of activity which brings the maximum change of attitude under a given condition of budget.

  13. Stochastic characteristics and modeling of relative humidity of Ogun ...

    African Journals Online (AJOL)

    Extreme events of atmospheric phenomena are often non deterministic in nature, and this has been a major constraint in achieving agricultural sustainability in most developing countries.To facilitate this study, 29 years information of the observed relative humidity of Ogun basin was obtained from the Federal Ministry of ...

  14. STUDY OF THE SEMI-THEORETICAL RELATION OF THE ...

    African Journals Online (AJOL)

    ABSTRACT. This study has for objective to study the theoretical relation of the hydraulic jump by sill, evolving in an U-shaped channel, with a rough bed. Functional relations, in non- dimensional form, relating the jump characteristics, seeming the effect of the bed's roughness, are obtained. A comparative study with the ...

  15. Relations between Effects and Structure of Small Bicyclic Molecules on the Complex Model System Saccharomyces cerevisiae

    OpenAIRE

    Brilli, Matteo; Trabocchi, Andrea; Weil, Tobias; Cavalieri, Duccio; Stefanini, Irene

    2017-01-01

    The development of compounds able to modify biological functions largely took advantage of parallel synthesis to generate a broad chemical variance of compounds to be tested for the desired effect(s). The budding yeast Saccharomyces cerevisiae is a model for pharmacological studies since a long time as it represents a relatively simple system to explore the relations among chemical variance and bioactivity. To identify relations between the chemical features of the molecules and their activit...

  16. Novel swine model of transfusion-related acute lung injury.

    Science.gov (United States)

    Okazaki, Hitoshi; Ishikawa, Osamu; Iijima, Takehiko; Kohira, Takahiro; Teranishi, Mai; Kawasaki, Shin; Saito, Akira; Mikami, Yu; Sugiura, Asuka; Hashimoto, Shiho; Shimada, Eiko; Uchikawa, Makoto; Matsuhashi, Mika; Tsuno, Nelson H; Tanaka, Minoru; Kiyokawa, Nobutaka; Fujimoto, Junichiro; Nagase, Takahide; Tadokoro, Kenji; Takahashi, Koki

    2014-12-01

    Transfusion-related acute lung injury (TRALI) is a life-threatening complication of blood transfusion. Antibodies against human leukocyte antigens in donors' plasma are the major causes of TRALI. Several animal models of TRALI have been developed, and the mechanism underlying TRALI development has been extensively investigated using rodent models. Although sheep models of nonimmune TRALI have been developed, large-animal models of antibody-mediated TRALI are not yet available. To develop a swine model of TRALI, male Clawn strain miniature pigs were used. A monoclonal antibody (MoAb) against swine leukocyte antigens (SLAs) Class I (4G8, 0.3 or 1.0 mg/kg body weight [BW]) and a control antibody (1.0 mg/kg BW) were injected into the peripheral vein after priming with or without 1 μg/kg BW lipopolysaccharide (LPS; n = 3 each). Lung injury was assessed using PaO2 /FiO2 (P/F) ratio and by chest X-ray imaging. Histopathologic analysis was also conducted. Lung injury could be induced by injecting 4G8 at an amount of 1.0 mg/kg BW, after LPS. The P/F ratio 90 minutes after the administration of 4G8 significantly decreased (p Lung injury was confirmed by histopathologic analysis. Lung injury in pigs was successfully induced by anti-SLA MoAb. Priming with LPS is a prerequisite for inducing lung injury and the amount of the antibody is a critical condition. © 2014 AABB.

  17. Is the demand-control model still a usefull tool to assess work-related psychosocial risk for ischemic heart disease? Results from 14 year follow up in the Copenhagen City Heart study.

    Science.gov (United States)

    Netterstrøm, Bo; Kristensen, Tage S; Jensen, Gorm; Schnor, Peter

    2010-01-01

    To test the usefulness of the Demand-Control Model as predictor for ischemic heart disease (IHD). One thousand one hundred forty six actively employed men and women from the general population of Copenhagen participated at baseline in 1993-1994. They filled in questionnaires on the Demand-Control Model, job title, work place, civil status, family income, leisure time activity, smoking, medication, social support, social relations, conflicts, job responsibility, satisfaction, and insecurity and went through a medical examination, including measurements of coronary risk factors. All deaths and hospital admissions due to IHD, including first myocardial infarction (MI) in the cohort were traced in the Danish registries of deaths and hospital admissions to June 2007. 104 cases of first time hospitalisation or death due to IHD including 49 cases of MI occurred during 14 years follow up. Odds ratio (OR) compared to the relaxed group was 1.1 (0.1-3.1) among women and 1.6 (0.4-4.9) among men after confounder adjustment. Neither demands nor control were significantly associated with IHD. Among men 50 years of age or more, the risk for IHD was, however, elevated in the job strain group and the active group (OR = 3.5 and 3.2 respectively). Job insecurity was, however, strongly associated with IHD in men (OR = 2.7 (1.1-5.6)) after all adjustments. The risk was increased for MI too (OR = 2.7 (1.2-6.1)). Among women, the only significant association with IHD was for job dissatisfaction (OR = 3.0 (1.2-7.6)). In this population and in a period and society characterized by relative wealth and increasing employment rates, the Demand-control Model did not predict IHD. However, the feeling of job insecurity predicted both IHD and MI among men and job dissatisfaction predicted IHD among women.

  18. Experimental and modelling studies of infiltration

    International Nuclear Information System (INIS)

    Giudici, M.

    2004-01-01

    This presentation describes a study of infiltration in the unsaturated soil with the objective of estimating the recharge to a phreatic aquifer. The study area is at the border of the city of Milan (Northern Italy), which draws water for both domestic and industrial purposes from ground water resources located beneath the urban area. The rate of water pumping from the aquifer system has been varying during the XX century, depending upon the number of inhabitants and the development of industrial activities. This caused variations with time of the depth of the water table below the ground surface and in turn some emergencies: the two most prominent episodes correspond to the middle '70s, when the water table in the city centre was about 30 m below the undisturbed natural conditions, and to the last decade, when the water table has raised at a rate of approximately 1 m/year and caused infiltrations in deep constructions (garages and building foundations, the underground railways, etc.). We have developed four ground water flow models at different scales, which share some characteristics: they are based on quasi-3D approximation (horizontal flow in the aquifers and vertical flow in the aquitards), conservative finite-differences schemes for regular grid with square cells in the horizontal plane and are implemented with proprietary computer codes. Among the problems that were studied for the development of these models, I recall some numerical problems, related to the behaviour of the phreatic aquifer under conditions of strong exploitation. Model calibration and validation for ModMil has been performed with a two-stage process, i.e., using some of the available data for model calibration and the remaining data for model validation. The application of geophysical exploration techniques, in particular seismic and geo-electrical prospecting, has been very useful to complete the data and information on the hydro-geological structure obtained from stratigraphic logs

  19. Variables relacionadas con la satisfacción laboral: un estudio transversal a partir del modelo EFQM Variables related to job satisfaction: Cross-sectional study using the European Foundation for Quality Management (EFQM model

    Directory of Open Access Journals (Sweden)

    Mónica Robles-García

    2005-04-01

    hospital. Methods: We performed a cross-sectional study in November 2003. The questionnaire used was the personal satisfaction survey of the Basque Country (Spain. The outcome measure was a high degree of satisfaction (75th percentile or higher. Independent variables were sociodemographic and organizational characteristics. The association among variables was assessed using odds ratios (OR and their 95% confidence interval (CI. Adjustment for confounders was performed by unconditional logistic regression. Results: On a scale from 0 to 10, the mean general satisfaction score was 5.95 (standard deviation, 2. Twenty-five percent of workers gave their general satisfaction with the organizational climate a score of 8 or more points. The most positively considered features were the environmental policy, hierarchical relations, promotion, and professional development. The most negatively viewed items were salary, knowledge and identification of objectives, and training. The variables most closely related to outcome were a favorable perception of training (adjusted OR = 5.04; 95% CI, 2.16-11.77 and recognition of the work performed (adjusted OR = 4.68; 95% CI, 2.20-10.08. Sociodemographic factors had less influence on satisfaction. Conclusions: Almost half of the staff surveyed in our hospital were satisfied or highly satisfied with the organizational climate. Satisfaction was strongly associated with positive evaluation of organizational characteristics.

  20. Resource Tracking Model Updates and Trade Studies

    Science.gov (United States)

    Chambliss, Joe; Stambaugh, Imelda; Moore, Michael

    2016-01-01

    The Resource Tracking Model has been updated to capture system manager and project manager inputs. Both the Trick/General Use Nodal Network Solver Resource Tracking Model (RTM) simulator and the RTM mass balance spreadsheet have been revised to address inputs from system managers and to refine the way mass balance is illustrated. The revisions to the RTM included the addition of a Plasma Pyrolysis Assembly (PPA) to recover hydrogen from Sabatier Reactor methane, which was vented in the prior version of the RTM. The effect of the PPA on the overall balance of resources in an exploration vehicle is illustrated in the increased recycle of vehicle oxygen. Case studies have been run to show the relative effect of performance changes on vehicle resources.

  1. General relativity cosmological models without the big bang

    International Nuclear Information System (INIS)

    Rosen, N.

    1985-01-01

    Attention is given to the so-called standard model of the universe in the framework of the general theory of relativity. This model is taken to be homogeneous and isotropic and filled with an ideal fluid characterized by a density and a pressure. Taking into consideration, however, the assumption that the universe began in a singular state, it is found hard to understand why the universe is so nearly homogeneous and isotropic at present for a singularity represents a breakdown of physical laws, and the initial singularity cannot, therefore, predetermine the subsequent symmetries of the universe. The present investigation has the objective to find a way of avoiding this initial singularity, i.e., to look for a cosmological model without the big bang. The idea is proposed that there exists a limiting density of matter of the order of magnitude of the Planck density, and that this was the density of matter at the moment at which the universe began to expand

  2. Cellular models and therapies for age-related macular degeneration

    Directory of Open Access Journals (Sweden)

    David L. Forest

    2015-05-01

    Full Text Available Age-related macular degeneration (AMD is a complex neurodegenerative visual disorder that causes profound physical and psychosocial effects. Visual impairment in AMD is caused by the loss of retinal pigmented epithelium (RPE cells and the light-sensitive photoreceptor cells that they support. There is currently no effective treatment for the most common form of this disease (dry AMD. A new approach to treating AMD involves the transplantation of RPE cells derived from either human embryonic or induced pluripotent stem cells. Multiple clinical trials are being initiated using a variety of cell therapies. Although many animal models are available for AMD research, most do not recapitulate all aspects of the disease, hampering progress. However, the use of cultured RPE cells in AMD research is well established and, indeed, some of the more recently described RPE-based models show promise for investigating the molecular mechanisms of AMD and for screening drug candidates. Here, we discuss innovative cell-culture models of AMD and emerging stem-cell-based therapies for the treatment of this vision-robbing disease.

  3. New extended standard model, dark matters and relativity theory

    Science.gov (United States)

    Hwang, Jae-Kwang

    2016-03-01

    Three-dimensional quantized space model is newly introduced as the extended standard model. Four three-dimensional quantized spaces with total 12 dimensions are used to explain the universes including ours. Electric (EC), lepton (LC) and color (CC) charges are defined to be the charges of the x1x2x3, x4x5x6 and x7x8x9 warped spaces, respectively. Then, the lepton is the xi(EC) - xj(LC) correlated state which makes 3x3 = 9 leptons and the quark is the xi(EC) - xj(LC) - xk(CC) correlated state which makes 3x3x3 = 27 quarks. The new three bastons with the xi(EC) state are proposed as the dark matters seen in the x1x2x3 space, too. The matter universe question, three generations of the leptons and quarks, dark matter and dark energy, hadronization, the big bang, quantum entanglement, quantum mechanics and general relativity are briefly discussed in terms of this new model. The details can be found in the article titled as ``journey into the universe; three-dimensional quantized spaces, elementary particles and quantum mechanics at https://www.researchgate.net/profile/J_Hwang2''.

  4. The Relational Health Indices: A Study of Women's Relationships

    Science.gov (United States)

    Liang, Belle; Tracy, Allison; Taylor, Catherine A.; Williams, Linda M.; Jordan, Judith V.; Miller, Jean Baker

    2002-01-01

    A new measure of women's relationships, the Relational Health Indices (RHI), comprises three scales that assess growth-fostering connections with peers, mentors, and communities. The RHI was developed using the Relational Model (Jordan, Kaplan, Miller, Stiver, Surrey, 1991; Miller & Stiver, 1997), a theory of women's psychological development.…

  5. The Lancet Countdown on PM2·5 pollution-related health impacts of China's projected carbon dioxide mitigation in the electric power generation sector under the Paris Agreement: a modelling study

    Directory of Open Access Journals (Sweden)

    Wenjia Cai, PhD

    2018-04-01

    Full Text Available Summary: Background: Except for comparing the implementation costs of the Paris Agreement with potential health benefits at the national levels, previous studies have not explored the health impacts of the nationally determined contributions (NDCs by countries and in regional details. In this Lancet Countdown study, we aimed to estimate and monetise the health benefits of China's NDCs in the electric power generation sector, and then compare them with the implementation costs, both at the national and regional levels. Methods: In this modelling study, we linked the Multi-regional model for Energy Supply system and their Environmental ImpaCts, the Multi-resolution Emission Inventory for China model, the offline-coupled Weather Research and Forecasting model, the Community Multiscale Air Quality model, and the Integrated Health Impact Assessment model with a time scope from 2010 to 2050. We calculated the PM2·5 concentrations and compared the health impacts and implementation costs between two scenarios that reflect CO2 and air pollutant emissions—the reference (REF scenario (no climate policy and the NDC scenario (100% realisation of NDC targets: CO2 emission intensity needs to be about 40% below 2010 emissions by 2030 [roughly 35% below 2030 emissions in REF], and about 90% below 2010 emissions by 2050 [roughly 96% below 2050 emissions in REF]. Findings: Under a comparatively optimistic health benefits valuation condition, at the national level, 18–62% of implementation costs could be covered by the health benefits in 2030. In 2050, the overall health benefits would substantially increase to 3–9 times of the implementation costs. However, northwest China would require the highest implementation costs and will also have more premature deaths because of a more carbon-intensive energy structure than business as usual. By 2030, people in northwest China (especially in Gansu, Shaanxi, and Xinjiang provinces would need to bear worse air quality

  6. Radionuclides in fruit systems: Model-model intercomparison study

    Energy Technology Data Exchange (ETDEWEB)

    Linkov, I. [Cambridge Environmental, 58 Charles Street, Cambridge, MA 02141 (United States)]. E-mail: linkov@cambridgeenvironmental.com; Carini, F. [Universita Cattolica del Sacro Cuore, Faculty of Agricultural Sciences, Institute of Agricultural and Environmental Chemistry, Via Emilia Parmense, 84, I-29100 Piacenza (Italy); Collins, C. [T.H. Huxley School of Environment, Earth Sciences and Engineering (United Kingdom); Eged, K. [Department of Radiochemistry, University of Veszprem, P.O. Box 158 H-8201, H-8200 Veszprem (Hungary); Mitchell, N.G. [Mouchel Consulting Ltd., West Hall, Parvis Road, West Byfleet, Surrey, KT14 6EZ (United Kingdom); Mourlon, C. [Institute of Protection and Nuclear Safety (IPSN)/Division of Environmental Protection (DPRE), Laboratory of Environmental Modelling - LMODE, CE/Cadarache, 13 108 St Paul-lez-Durance Cedex (France); Ould-Dada, Z. [Food Standards Agency, Radiological Protection and Research Management Division, Aviation House, 125 Kingsway, Room 715B, London WC2B 6NH (United Kingdom); Robles, B. [CIEMAT, Dept. de Impacto Ambiental (DIAE), Edif. 3A, Avenida Complutense 22, E-28040 Madrid (Spain); Sweeck, L. [SCK.CEN, Boeretang 200, 2400 Mol (Belgium); Venter, A. [Enviros Consulting Ltd., Telegraphic House, Waterfront Quay, Salford Quays, Greater Manchester, M50 3XW (United Kingdom)

    2006-07-01

    Modeling is widely used to predict radionuclide distribution following accidental radionuclide releases. Modeling is crucial in emergency response planning and risk communication, and understanding model uncertainty is important not only in conducting analysis consistent with current regulatory guidance, but also in gaining stakeholder and decision-maker trust in the process and confidence in the results. However, while methods for dealing with parameter uncertainty are fairly well developed, an adequate representation of uncertainties associated with models remains rare. This paper addresses uncertainty about a model's structure (i.e., the relevance of simplifying assumptions and mathematical equations) that is seldom addressed in practical applications of environmental modeling. The use of several alternative models to derive a range of model outputs or risks is probably the only available technique to assess consistency in model prediction. Since each independent model requires significant resources for development and calibration, multiple models are not generally applied to the same problem. This study uses results from one such model intercomparison conducted by the Fruits Working Group, which was created under the International Atomic Energy Agency (IAEA) BIOMASS (BIOsphere Modelling and ASSessment) Program. Model-model intercomparisons presented in this study were conducted by the working group for two different scenarios (acute or continuous deposition), one radionuclide ({sup 137}Cs), and three fruit-bearing crops (strawberries, apples, and blackcurrants). The differences between models were as great as five orders of magnitude for short-term predictions following acute radionuclide deposition. For long-term predictions and for the continuous deposition scenario, the differences between models were about two orders of magnitude. The difference between strawberry, apple, and blackcurrant contamination predicted by one model is far less than the

  7. Radionuclides in fruit systems. Model-model intercomparison study

    Energy Technology Data Exchange (ETDEWEB)

    Linkov, I. [Cambridge Environmental, 58 Charles Street, Cambridge, MA 02141 (United States); Carini, F. [Universita Cattolica del Sacro Cuore, Faculty of Agricultural Sciences, Institute of Agricultural and Environmental Chemistry, Via Emilia Parmense, 84, I-29100 Piacenza (Italy); Collins, C. [T.H. Huxley School of Environment, Earth Sciences and Engineering (United Kingdom); Eged, K. [Department of Radiochemistry, University of Veszprem, P.O. Box 158 H-8201, H-8200 Veszprem (Hungary); Mitchell, N.G. [Mouchel Consulting Ltd., West Hall, Parvis Road, West Byfleet, Surrey, KT14 6EZ (United Kingdom); Mourlon, C. [Institute of Protection and Nuclear Safety IPSN, Division of Environmental Protection (DPRE), Laboratory of Environmental Modelling LMODE, CE/Cadarache, 13 108 St Paul-lez-Durance (France); Ould-Dada, Z. [Food Standards Agency, Radiological Protection and Research Management Division, Aviation House, 125 Kingsway, Room 715B, London WC2B 6NH (United Kingdom); Robles, B. [CIEMAT, Dept. de Impacto Ambiental (DIAE), Edif. 3A, Avenida Complutense 22, E-28040 Madrid (Spain); Sweeck, L. [SCK-CEN, Boeretang 200, 2400 Mol (Belgium); Venter, A. [Enviros Consulting Ltd., Telegraphic House, Waterfront Quay, Salford Quays, Greater Manchester, M50 3XW (United Kingdom)

    2006-07-01

    Modeling is widely used to predict radionuclide distribution following accidental radionuclide releases. Modeling is crucial in emergency response planning and risk communication, and understanding model uncertainty is important not only in conducting analysis consistent with current regulatory guidance, but also in gaining stakeholder and decision-maker trust in the process and confidence in the results. However, while methods for dealing with parameter uncertainty are fairly well developed, an adequate representation of uncertainties associated with models remains rare. This paper addresses uncertainty about a model's structure (i.e., the relevance of simplifying assumptions and mathematical equations) that is seldom addressed in practical applications of environmental modeling. The use of several alternative models to derive a range of model outputs or risks is probably the only available technique to assess consistency in model prediction. Since each independent model requires significant resources for development and calibration, multiple models are not generally applied to the same problem. This study uses results from one such model intercomparison conducted by the Fruits Working Group, which was created under the International Atomic Energy Agency (IAEA) BIOMASS (BIOsphere Modelling and ASSessment) Program. Model-model intercomparisons presented in this study were conducted by the working group for two different scenarios (acute or continuous deposition), one radionuclide ({sup 137}Cs), and three fruit-bearing crops (strawberries, apples, and blackcurrants). The differences between models were as great as five orders of magnitude for short-term predictions following acute radionuclide deposition. For long-term predictions and for the continuous deposition scenario, the differences between models were about two orders of magnitude. The difference between strawberry, apple, and blackcurrant contamination predicted by one model is far less than the

  8. Related work on reference modeling for collaborative networks

    NARCIS (Netherlands)

    Afsarmanesh, H.; Camarinha-Matos, L.M.; Camarinha-Matos, L.M.; Afsarmanesh, H.

    2008-01-01

    Several international research and development initiatives have led to development of models for organizations and organization interactions. These models and their approaches constitute a background for development of reference models for collaborative networks. A brief survey of work on modeling

  9. Some computer simulations based on the linear relative risk model

    International Nuclear Information System (INIS)

    Gilbert, E.S.

    1991-10-01

    This report presents the results of computer simulations designed to evaluate and compare the performance of the likelihood ratio statistic and the score statistic for making inferences about the linear relative risk mode. The work was motivated by data on workers exposed to low doses of radiation, and the report includes illustration of several procedures for obtaining confidence limits for the excess relative risk coefficient based on data from three studies of nuclear workers. The computer simulations indicate that with small sample sizes and highly skewed dose distributions, asymptotic approximations to the score statistic or to the likelihood ratio statistic may not be adequate. For testing the null hypothesis that the excess relative risk is equal to zero, the asymptotic approximation to the likelihood ratio statistic was adequate, but use of the asymptotic approximation to the score statistic rejected the null hypothesis too often. Frequently the likelihood was maximized at the lower constraint, and when this occurred, the asymptotic approximations for the likelihood ratio and score statistics did not perform well in obtaining upper confidence limits. The score statistic and likelihood ratio statistics were found to perform comparably in terms of power and width of the confidence limits. It is recommended that with modest sample sizes, confidence limits be obtained using computer simulations based on the score statistic. Although nuclear worker studies are emphasized in this report, its results are relevant for any study investigating linear dose-response functions with highly skewed exposure distributions. 22 refs., 14 tabs

  10. Parameterizing Dose-Response Models to Estimate Relative Potency Functions Directly

    Science.gov (United States)

    Dinse, Gregg E.

    2012-01-01

    Many comparative analyses of toxicity assume that the potency of a test chemical relative to a reference chemical is constant, but employing such a restrictive assumption uncritically may generate misleading conclusions. Recent efforts to characterize non-constant relative potency rely on relative potency functions and estimate them secondarily after fitting dose-response models for the test and reference chemicals. We study an alternative approach of specifying a relative potency model a priori and estimating it directly using the dose-response data from both chemicals. We consider a power function in dose as a relative potency model and find that it keeps the two chemicals’ dose-response functions within the same family of models for families typically used in toxicology. When differences in the response limits for the test and reference chemicals are attributable to the chemicals themselves, the older two-stage approach is the more convenient. When differences in response limits are attributable to other features of the experimental protocol or when response limits do not differ, the direct approach is straightforward to apply with nonlinear regression methods and simplifies calculation of simultaneous confidence bands. We illustrate the proposed approach using Hill models with dose-response data from U.S. National Toxicology Program bioassays. Though not universally applicable, this method of estimating relative potency functions directly can be profitably applied to a broad family of dose-response models commonly used in toxicology. PMID:22700543

  11. Gender-related model for mobile-based learning

    Science.gov (United States)

    Simanjuntak, R. R.; Dewi, U. P.; Rifai, I.

    2018-03-01

    The study investigates gender influence on mobile-based learning. This case study of university students in Jakarta involved 235 students (128 male, 97 female). Results of this qualitative study showed 96% preference for mobile-based learning. A further 94% showed the needs for collaboration and authenticity for 92%. Hofstede’s cultural dimensions were used to identify the gender aspects of MALL. Preference for Masculinity (65%) was showed rather than Femininity (35%), even among the female respondents (70% of the population). Professions and professionalism received strongest preference (70%) while Individuality and Collectivism had equal preferences among students. Both female and male respondents requested Indulgence (84%) for mobile-based learning with more male respondents opted for Indulgence. The study provided a model for this gender sensitive mobile-based learning. Implications of implementing mobile-based learning as an ideal alternative for well-accommodated education are is also discussed.

  12. Screening design for model sensitivity studies

    Science.gov (United States)

    Welsh, James P.; Koenig, George G.; Bruce, Dorothy

    1997-07-01

    This paper describes a different approach to sensitivity studies for environmental, including atmospheric, physics models. The sensitivity studies were performed on a multispectral environmental data and scene generation capability. The capability includes environmental physics models that are used to generate data and scenes for simulation of environmental materials, features, and conditions, such as trees, clouds, soils, and snow. These studies were performed because it is difficult to obtain input data for many of the environmental variables. The problem to solve is to determine which of the 100 or so input variables, used by the generation capability, are the most important. These sensitivity studies focused on the generation capabilities needed to predict and evaluate the performance of sensor systems operating in the infrared portions of the electromagnetic spectrum. The sensitivity study approach described uses a screening design. Screening designs are analytical techniques that use a fraction of all of the combinations of the potential input variables and conditions to determine which are the most important. Specifically a 20-run Plackett-Burman screening design was used to study the sensitivity of eight data and scene generation capability computed response variables to 11 selected input variables. This is a two-level design, meaning that the range of conditions is represented by two different values for each of the 11 selected variables. The eight response variables used were maximum, minimum, range, and mode of the model-generated temperature and radiance values. The result is that six of the 11 input variables (soil moisture, solar loading, roughness length, relative humidity, surface albedo, and surface emissivity) had a statistically significant effect on the response variables.

  13. Adaptation to Climate Change: A Comparative Analysis of Modeling Methods for Heat-Related Mortality.

    Science.gov (United States)

    Gosling, Simon N; Hondula, David M; Bunker, Aditi; Ibarreta, Dolores; Liu, Junguo; Zhang, Xinxin; Sauerborn, Rainer

    2017-08-16

    Multiple methods are employed for modeling adaptation when projecting the impact of climate change on heat-related mortality. The sensitivity of impacts to each is unknown because they have never been systematically compared. In addition, little is known about the relative sensitivity of impacts to "adaptation uncertainty" (i.e., the inclusion/exclusion of adaptation modeling) relative to using multiple climate models and emissions scenarios. This study had three aims: a ) Compare the range in projected impacts that arises from using different adaptation modeling methods; b ) compare the range in impacts that arises from adaptation uncertainty with ranges from using multiple climate models and emissions scenarios; c ) recommend modeling method(s) to use in future impact assessments. We estimated impacts for 2070-2099 for 14 European cities, applying six different methods for modeling adaptation; we also estimated impacts with five climate models run under two emissions scenarios to explore the relative effects of climate modeling and emissions uncertainty. The range of the difference (percent) in impacts between including and excluding adaptation, irrespective of climate modeling and emissions uncertainty, can be as low as 28% with one method and up to 103% with another (mean across 14 cities). In 13 of 14 cities, the ranges in projected impacts due to adaptation uncertainty are larger than those associated with climate modeling and emissions uncertainty. Researchers should carefully consider how to model adaptation because it is a source of uncertainty that can be greater than the uncertainty in emissions and climate modeling. We recommend absolute threshold shifts and reductions in slope. https://doi.org/10.1289/EHP634.

  14. Implementation of a fuzzy relational database. Case study: academic tutoring

    Directory of Open Access Journals (Sweden)

    Ciro Saguay

    2017-02-01

    Full Text Available This paper describes the process of implementation of a diffused relational database in the practical case of the academic tutorials of the Faculty of Engineering Sciences of the Equinoctial Technological University (UTE. For the implementation, the ANSI-SPARC database architecture was used as the methodology, which abstracts the information into levels, at the external level the functional requirements were obtained, at the conceptual level, the diffused relational model was obtained. To achieve this model, we performed the transformation of the diffuse data through mathematical models using the Fuzzy-Lookup tool and at the physical level the diffused relational database was implemented. In addition, an user interface was developed using Java through which data is entered and queries are made to the diffused relational database to verify its operation.

  15. Modelling the genetic risk in age-related macular degeneration.

    Directory of Open Access Journals (Sweden)

    Felix Grassmann

    Full Text Available Late-stage age-related macular degeneration (AMD is a common sight-threatening disease of the central retina affecting approximately 1 in 30 Caucasians. Besides age and smoking, genetic variants from several gene loci have reproducibly been associated with this condition and likely explain a large proportion of disease. Here, we developed a genetic risk score (GRS for AMD based on 13 risk variants from eight gene loci. The model exhibited good discriminative accuracy, area-under-curve (AUC of the receiver-operating characteristic of 0.820, which was confirmed in a cross-validation approach. Noteworthy, younger AMD patients aged below 75 had a significantly higher mean GRS (1.87, 95% CI: 1.69-2.05 than patients aged 75 and above (1.45, 95% CI: 1.36-1.54. Based on five equally sized GRS intervals, we present a risk classification with a relative AMD risk of 64.0 (95% CI: 14.11-1131.96 for individuals in the highest category (GRS 3.44-5.18, 0.5% of the general population compared to subjects with the most common genetic background (GRS -0.05-1.70, 40.2% of general population. The highest GRS category identifies AMD patients with a sensitivity of 7.9% and a specificity of 99.9% when compared to the four lower categories. Modeling a general population around 85 years of age, 87.4% of individuals in the highest GRS category would be expected to develop AMD by that age. In contrast, only 2.2% of individuals in the two lowest GRS categories which represent almost 50% of the general population are expected to manifest AMD. Our findings underscore the large proportion of AMD cases explained by genetics particularly for younger AMD patients. The five-category risk classification could be useful for therapeutic stratification or for diagnostic testing purposes once preventive treatment is available.

  16. Hildegard E. Peplau in model medosebnih odnosov: Hildegard E. Peplau and the model interpersonal relations:

    OpenAIRE

    Ramšak-Pajk, Jožica

    2000-01-01

    The first part of the article shortly introduces Hildegard Peplau and defines her theory of interpersonal relations between nurse and patient. The four phases of the theory and the different roles, which the nurse takes through them, are described. In conclusion the article discusses the possibility of the application of the model of interpersonal relations to the nursing process. The conclusion emphasizes the value of the use of the mentioned modeland effective communication between nurse an...

  17. Relating Cohesive Zone Model to Linear Elastic Fracture Mechanics

    Science.gov (United States)

    Wang, John T.

    2010-01-01

    The conditions required for a cohesive zone model (CZM) to predict a failure load of a cracked structure similar to that obtained by a linear elastic fracture mechanics (LEFM) analysis are investigated in this paper. This study clarifies why many different phenomenological cohesive laws can produce similar fracture predictions. Analytical results for five cohesive zone models are obtained, using five different cohesive laws that have the same cohesive work rate (CWR-area under the traction-separation curve) but different maximum tractions. The effect of the maximum traction on the predicted cohesive zone length and the remote applied load at fracture is presented. Similar to the small scale yielding condition for an LEFM analysis to be valid. the cohesive zone length also needs to be much smaller than the crack length. This is a necessary condition for a CZM to obtain a fracture prediction equivalent to an LEFM result.

  18. BIOMOVS: an international model validation study

    International Nuclear Information System (INIS)

    Haegg, C.; Johansson, G.

    1988-01-01

    BIOMOVS (BIOspheric MOdel Validation Study) is an international study where models used for describing the distribution of radioactive and nonradioactive trace substances in terrestrial and aquatic environments are compared and tested. The main objectives of the study are to compare and test the accuracy of predictions between such models, explain differences in these predictions, recommend priorities for future research concerning the improvement of the accuracy of model predictions and act as a forum for the exchange of ideas, experience and information. (author)

  19. BIOMOVS: An international model validation study

    International Nuclear Information System (INIS)

    Haegg, C.; Johansson, G.

    1987-01-01

    BIOMOVS (BIOspheric MOdel Validation Study) is an international study where models used for describing the distribution of radioactive and nonradioactive trace substances in terrestrial and aquatic environments are compared and tested. The main objectives of the study are to compare and test the accuracy of predictions between such models, explain differences in these predictions, recommend priorities for future research concerning the improvement of the accuracy of model predictions and act as a forum for the exchange of ideas, experience and information. (orig.)

  20. On quark model relations for hypercharge-exchange reactions

    International Nuclear Information System (INIS)

    Kluyver, J.C.; Blokzijl, R.; Massaro, G.G.G.; Wolters, G.F.; Grossmann, P.; Lamb, P.R.; Wells, J.

    1978-01-01

    Peripheral two-body reactions of the type K - p → M 0 + Λ, Σ 0 or Σ 0 (1385) are considered. Predictions based on the additive quark model and SU(6) baryon wave functions are tested against data on cross sections and polarisations for given momentum transfer. Data obtained in a high statistics experiment at 4.2 GeV/c K - momentum, as well as data from a large variety of other experiments are used. Highly significant violations of these predictions are observed in the data. These violations are shown to occur in a systematic fashion, according to which SU(6) must be relaxed, but the amplitude structure implied by additivity would remain valid. As an application an amplitude analysis for natural parity exchange reactions with M 0 = π, phi and rho respectively is performed, which determines a relative phase, which cannot be obtained in model-independent analysis. Also reactions with M 0 = delta or B are considered, and some implications for coupling constants are discussed. (Auth.)

  1. Modelling lifestyle effects on energy demand and related emissions

    International Nuclear Information System (INIS)

    Weber, C.

    2000-01-01

    An approach to analyse and quantify the impact of lifestyle factors on current and future energy demand is developed. Thereby not only directly environmentally relevant consumer activities such as car use or heating have been analysed, but also expenditure patterns which induce environmental damage through the production of the consumed goods. The use of household survey data from the national statistical offices offers the possibility to cover this wide range of activities. For the available social-economic household characteristics a variety of different behavioural patterns have been observed. For evaluating the energy and emission consequences of the consumed goods enhanced input-output models are used. The additions implemented - a mixed monetary-energetic approach for inter-industry flows and a separate treatment of transport -related emissions - improve the reliability of the obtained results. The developed approach has been used for analysing current emissions profiles and distributions in West Germany, France and the Netherlands as well as scenarios for future energy demand and related emissions. It therefore provides a comprehensive methodology to analyse environmental effects in a consumer and citizen perspective and thus contributes to an increase transparency of complex economic and ecological interconnections. (author)

  2. Zebrafish as a Model to Investigate Dynamin 2-Related Diseases.

    Science.gov (United States)

    Bragato, Cinzia; Gaudenzi, Germano; Blasevich, Flavia; Pavesi, Giulio; Maggi, Lorenzo; Giunta, Michele; Cotelli, Franco; Mora, Marina

    2016-02-04

    Mutations in the dynamin-2 gene (DNM2) cause autosomal dominant centronuclear myopathy (CNM) and dominant intermediate Charcot-Marie-Tooth (CMT) neuropathy type B (CMTDIB). As the relation between these DNM2-related diseases is poorly understood, we used zebrafish to investigate the effects of two different DNM2 mutations. First we identified a new alternatively spliced zebrafish dynamin-2a mRNA (dnm2a-v2) with greater similarity to human DNM2 than the deposited sequence. Then we knocked-down the zebrafish dnm2a, producing defects in muscle morphology. Finally, we expressed two mutated DNM2 mRNA by injecting zebrafish embryos with human mRNAs carrying the R522H mutation, causing CNM, or the G537C mutation, causing CMT. Defects arose especially in secondary motor neuron formation, with incorrect branching in embryos injected with CNM-mutated mRNA, and total absence of branching in those injected with CMT-mutated mRNA. Muscle morphology in embryos injected with CMT-mutated mRNA appeared less regularly organized than in those injected with CNM-mutated mRNA. Our results showing, a continuum between CNM and CMTDIB phenotypes in zebrafish, similarly to the human conditions, confirm this animal model to be a powerful tool to investigate mutations of DNM2 in vivo.

  3. A conceptual model for work-related neck and upper-limb musculoskeletal disorders.

    Science.gov (United States)

    Armstrong, T J; Buckle, P; Fine, L J; Hagberg, M; Jonsson, B; Kilbom, A; Kuorinka, I A; Silverstein, B A; Sjogaard, G; Viikari-Juntura, E R

    1993-04-01

    This paper presents a conceptual model for the pathogenesis of work-related musculoskeletal disorders. The model contains sets of cascading exposure, dose, capacity, and response variables, such that response at one level can act as dose at the next. Response to one or more doses can diminish or increase the capacity for responding to successive doses. The model is used as a framework for discussing the development of work-related muscle, tendon, and nerve disorders. It is intended as a beginning, to be modified to explain new findings as they become available. In research, it can help to identify areas needing additional data for the development and expression of work-related musculoskeletal disorders. Researchers can use it to design laboratory and field studies. In practice, it demonstrates the relationship between common exposure factors and different responses. This information can be used to evaluate and design jobs for the prevention of work-related musculoskeletal disorders.

  4. Imitation Modeling and Institutional Studies

    Directory of Open Access Journals (Sweden)

    Maksim Y. Barbashin

    2017-09-01

    Full Text Available This article discusses the use of imitation modeling in the conduct of institutional research. The institutional approach is based on the observation of social behavior. To understand a social process means to determine the key rules that individuals use, undertaking social actions associated with this process or phenomenon. This does not mean that institutions determine behavioral reactions, although there are a number of social situations where the majority of individuals follow the dominant rules. If the main laws of development of the institutional patterns are known, one can describe most of the social processes accurately. The author believes that the main difficulty with the analysis of institutional processes is their recursive nature: from the standards of behavior one may find the proposed actions of social agents who follow, obey or violate institutions, but the possibility of reconstructive analysis is not obvious. The author demonstrates how the institutional approach is applied to the analysis of social behavior. The article describes the basic principles and methodology of imitation modeling. Imitation modeling reveals the importance of institutions in structuring social transactions. The article concludes that in the long term institutional processes are not determined by initial conditions.

  5. Contributions towards uncertainty related to hydrostratigraphic modelling using Multiple-Point Statistics

    DEFF Research Database (Denmark)

    Barfod, Adrian; Vilhelmsen, Troels Norvin; Jørgensen, Flemming

    2017-01-01

    Accurately predicting the flow of groundwater requires a hydrostratigraphic model, which describes the structural architecture. State-of-the-art Multiple-Point Statistical (MPS) tools are readily available for creating models depicting subsurface geology. We present a study of the impact of key...... focuses on the error related to the geophysical soft data, borehole lithology logs, and the Training Image (TI). The modeling approach used in this paper utilizes the Kasted cognitive geological model as a TI to simulate ensemble hydrostratigraphic models. The target model contains three overall...... hydrostratigraphic categories, and the MPS realizations are compared visually, as well as quantitatively using mathematical measures of similarity between categorical 3D models. The quantitative similarity analysis is carried out exhaustively, and realizations are compared each other as well as the cognitive...

  6. Relations between a micro-mechanical model and a damage model for ductile failure in shear

    DEFF Research Database (Denmark)

    Tvergaard, Viggo; Nielsen, Kim Lau

    2010-01-01

    Gurson type constitutive models that account for void growth to coalescence are not able to describe ductile fracture in simple shear, where there is no hydrostatic tension in the material. But recent micro-mechanical studies have shown that in shear the voids are flattened out to micro......-cracks, which rotate and elongate until interaction with neighbouring micro-cracks gives coalescence. Thus, the failure mechanism is very different from that under tensile loading. Also, the Gurson model has recently been extended to describe failure in shear, by adding a damage term to the expression...... for the growth of the void volume fraction, and it has been shown that this extended model can represent experimental observations. Here, numerical studies are carried out to compare predictions of the shear-extended Gurson model with the shear failures predicted by the micro-mechanical cell model. Both models...

  7. Relating the new language models of information retrieval to the traditional retrieval models

    NARCIS (Netherlands)

    Hiemstra, Djoerd; de Vries, A.P.

    During the last two years, exciting new approaches to information retrieval were introduced by a number of different research groups that use statistical language models for retrieval. This paper relates the retrieval algorithms suggested by these approaches to widely accepted retrieval algorithms

  8. The Role of Human Relations and Interactions in Designing Memory-Related Models for Sensor Networks

    Directory of Open Access Journals (Sweden)

    Basim MAHMOOD

    2016-04-01

    Full Text Available Recently, the use of Wireless Sensor Networks has become substantial in most of our life aspects. These networks have many issues and challenges at the design phase (e.g., memory and power consumption. There exists a huge amount of works and studies that offer and provide solutions for many of these challenges. However, the issues of predicting memory requirements and memory management have not received enough attention in sensor networks literature. Yet, most of the studies in this field focus on issues related to power consumption and connectivity of sensor nodes. This paper has two main purposes: first, we propose a metric for measuring the strength of a relation between two sensors. In the proposed metric, we involve three important characteristics of human relations and interactions: encounter frequencies, duration of encounters, and regularities of encounters. We then exploit this metric in predicting memory requirements in a sensor network. Second, based on the estimated memory size, we propose an approach for memory management in a sensor network. The proposed approach is based on two concepts: social capital in sociology and preferential return in human mobility. The results show that our approach is effective in managing sensor memories comparing to other approaches in the literature.

  9. Building spatio-temporal database model based on ontological approach using relational database environment

    International Nuclear Information System (INIS)

    Mahmood, N.; Burney, S.M.A.

    2017-01-01

    Everything in this world is encapsulated by space and time fence. Our daily life activities are utterly linked and related with other objects in vicinity. Therefore, a strong relationship exist with our current location, time (including past, present and future) and event through with we are moving as an object also affect our activities in life. Ontology development and its integration with database are vital for the true understanding of the complex systems involving both spatial and temporal dimensions. In this paper we propose a conceptual framework for building spatio-temporal database model based on ontological approach. We have used relational data model for modelling spatio-temporal data content and present our methodology with spatio-temporal ontological accepts and its transformation into spatio-temporal database model. We illustrate the implementation of our conceptual model through a case study related to cultivated land parcel used for agriculture to exhibit the spatio-temporal behaviour of agricultural land and related entities. Moreover, it provides a generic approach for designing spatiotemporal databases based on ontology. The proposed model is capable to understand the ontological and somehow epistemological commitments and to build spatio-temporal ontology and transform it into a spatio-temporal data model. Finally, we highlight the existing and future research challenges. (author)

  10. Adjustment problems and maladaptive relational style: a mediational model of sexual coercion in intimate relationships.

    Science.gov (United States)

    Salwen, Jessica K; O'Leary, K Daniel

    2013-07-01

    Four hundred and fifty-three married or cohabitating couples participated in the current study. A meditational model of men's perpetration of sexual coercion within an intimate relationship was examined based on past theories and known correlates of rape and sexual coercion. The latent constructs of adjustment problems and maladaptive relational style were examined. Adjustment problem variables included perceived stress, perceived low social support, and marital discord. Maladaptive relational style variables included psychological aggression, dominance, and jealousy. Sexual coercion was a combined measure of men's reported perpetration and women's reported victimization. As hypothesized, adjustment problems significantly predicted sexual coercion. Within the meditational model, adjustment problems were significantly correlated with maladaptive relational style, and maladaptive relational style significantly predicted sexual coercion. Once maladaptive relational style was introduced as a mediator, adjustment problems no longer significantly predicted sexual coercion. Implications for treatment, limitations, and future research are discussed.

  11. The Lancet Countdown on PM2·5 pollution-related health impacts of China's projected carbon dioxide mitigation in the electric power generation sector under the Paris Agreement: a modelling study.

    Science.gov (United States)

    Cai, Wenjia; Hui, Jingxuan; Wang, Can; Zheng, Yixuan; Zhang, Xin; Zhang, Qiang; Gong, Peng

    2018-04-01

    Except for comparing the implementation costs of the Paris Agreement with potential health benefits at the national levels, previous studies have not explored the health impacts of the nationally determined contributions (NDCs) by countries and in regional details. In this Lancet Countdown study, we aimed to estimate and monetise the health benefits of China's NDCs in the electric power generation sector, and then compare them with the implementation costs, both at the national and regional levels. In this modelling study, we linked the Multi-regional model for Energy Supply system and their Environmental ImpaCts, the Multi-resolution Emission Inventory for China model, the offline-coupled Weather Research and Forecasting model, the Community Multiscale Air Quality model, and the Integrated Health Impact Assessment model with a time scope from 2010 to 2050. We calculated the PM 2·5 concentrations and compared the health impacts and implementation costs between two scenarios that reflect CO 2 and air pollutant emissions-the reference (REF) scenario (no climate policy) and the NDC scenario (100% realisation of NDC targets: CO 2 emission intensity needs to be about 40% below 2010 emissions by 2030 [roughly 35% below 2030 emissions in REF], and about 90% below 2010 emissions by 2050 [roughly 96% below 2050 emissions in REF]). Under a comparatively optimistic health benefits valuation condition, at the national level, 18-62% of implementation costs could be covered by the health benefits in 2030. In 2050, the overall health benefits would substantially increase to 3-9 times of the implementation costs. However, northwest China would require the highest implementation costs and will also have more premature deaths because of a more carbon-intensive energy structure than business as usual. By 2030, people in northwest China (especially in Gansu, Shaanxi, and Xinjiang provinces) would need to bear worse air quality, and 10 083 (95% CI 3419-16 138) more premature

  12. Estimating the relative position of risperidone primary binding site in Sera Albumins. Modeling from spectrofluorimetric data

    Science.gov (United States)

    Cortez, Celia Martins; Fragoso, Viviane Muniz S.; Silva, Dilson

    2014-10-01

    In this work, we used a mathematical model to study the interaction of risperidone with human and bovine serum albumins estimating the relative position of the primary binding site, based on the fluorescence quenching theory. Results have shown that the model was able to demonstrate that primary binding site for risperidone in HSA and BSA is very close to the position where is tryptophan 134 of BSA, possibly in domain 1B.

  13. Significance of predictive models/risk calculators for HBV-related hepatocellular carcinoma

    OpenAIRE

    DONG Jing

    2015-01-01

    Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is a major public health problem in Southeast Asia. In recent years, researchers from Hong Kong and Taiwan have reported predictive models or risk calculators for HBV-associated HCC by studying its natural history, which, to some extent, predicts the possibility of HCC development. Generally, risk factors of each model involve age, sex, HBV DNA level, and liver cirrhosis. This article discusses the evolution and clinical significa...

  14. The psychological influences on participation in Wheelchair Rugby: a social relational model of disability

    OpenAIRE

    Damian Haslett; Ben Fitzpatrick; Gavin Breslin

    2017-01-01

    Sport and exercise psychology research in disability sport seldom engages with social models of disability. As a result, the socio-historical landscape of disability is underrepresented in sport psychology research. The aim of this study is to interpret influences on participation in disability sport through the conceptual lens of the social relational model (SRM) of disability (Thomas, 1999, 2004, 2007). Ten Irish adult male athletes with physical disabilities participated in semi-structured...

  15. A Model for Relating Advertising Media Exposures to Purchase Incidence Behavior Patterns

    OpenAIRE

    Fred S. Zufryden

    1987-01-01

    A stochastic model is proposed to study the effect of advertising on consumer purchase dynamics by specifically relating the distribution of exposures, from a brand's media schedule, to brand purchase incidence behavior patterns over time. The approach is based on underlying individual consumer behavior assumptions that reflect the dynamics of exposures to advertising and brand purchase behavior, conditional on the level of advertising exposure received. Moreover, a population-based model is ...

  16. Modeling of ITER related vacuum gas pumping distribution systems

    Energy Technology Data Exchange (ETDEWEB)

    Misdanitis, Serafeim [University of Thessaly, Department of Mechanical Engineering, Pedion Areos, 38334 Volos (Greece); Association EURATOM - Hellenic Republic (Greece); Valougeorgis, Dimitris, E-mail: diva@mie.uth.gr [University of Thessaly, Department of Mechanical Engineering, Pedion Areos, 38334 Volos (Greece); Association EURATOM - Hellenic Republic (Greece)

    2013-10-15

    Highlights: • An algorithm to simulate vacuum gas flows through pipe networks consisting of long channels and channels of moderate length has been developed. • Analysis and results are based on kinetic theory as described by the BGK kinetic model equation. • The algorithm is capable of computing the mass flow rates (or the conductance) through the pipes and the pressure at the nodes of the network. • Since a kinetic approach is implemented, the algorithm is valid in the whole range of the Knudsen number. • The developed algorithm will be useful for simulating the vacuum distribution systems of ITER and future fusion reactors. -- Abstract: A novel algorithm recently developed to solve steady-state isothermal vacuum gas dynamics flows through pipe networks consisting of long tubes is extended to include, in addition to long channels, channels of moderate length 10 < L/D < 50. This is achieved by implementing the so-called end effect treatment/correction. Analysis and results are based on kinetic theory as described by the Boltzmann equation or associated reliable kinetic model equations. For a pipe network of known geometry the algorithm is capable of computing the mass flow rates (or the conductance) through the pipes as well as the pressure heads at the nodes of the network. The feasibility of the approach is demonstrated by simulating two ITER related vacuum distribution systems, one in the viscous regime and a second one in a wide range of Knudsen numbers. Since a kinetic approach is implemented, the algorithm is valid and the results are accurate in the whole range of the Knudsen number, while the involved computational effort remains small.

  17. Physical Model Method for Seismic Study of Concrete Dams

    Directory of Open Access Journals (Sweden)

    Bogdan Roşca

    2008-01-01

    Full Text Available The study of the dynamic behaviour of concrete dams by means of the physical model method is very useful to understand the failure mechanism of these structures to action of the strong earthquakes. Physical model method consists in two main processes. Firstly, a study model must be designed by a physical modeling process using the dynamic modeling theory. The result is a equations system of dimensioning the physical model. After the construction and instrumentation of the scale physical model a structural analysis based on experimental means is performed. The experimental results are gathered and are available to be analysed. Depending on the aim of the research may be designed an elastic or a failure physical model. The requirements for the elastic model construction are easier to accomplish in contrast with those required for a failure model, but the obtained results provide narrow information. In order to study the behaviour of concrete dams to strong seismic action is required the employment of failure physical models able to simulate accurately the possible opening of joint, sliding between concrete blocks and the cracking of concrete. The design relations for both elastic and failure physical models are based on dimensional analysis and consist of similitude relations among the physical quantities involved in the phenomenon. The using of physical models of great or medium dimensions as well as its instrumentation creates great advantages, but this operation involves a large amount of financial, logistic and time resources.

  18. An Exploratory Study: Assessment of Modeled Dioxin ...

    Science.gov (United States)

    EPA has released an external review draft entitled, An Exploratory Study: Assessment of Modeled Dioxin Exposure in Ceramic Art Studios(External Review Draft). The public comment period and the external peer-review workshop are separate processes that provide opportunities for all interested parties to comment on the document. In addition to consideration by EPA, all public comments submitted in accordance with this notice will also be forwarded to EPA’s contractor for the external peer-review panel prior to the workshop. EPA has realeased this draft document solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. This document has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency policy or determination. The purpose of this report is to describe an exploratory investigation of potential dioxin exposures to artists/hobbyists who use ball clay to make pottery and related products.

  19. Drying characteristics and modeling of yam slices under different relative humidity conditions

    Science.gov (United States)

    The drying characteristics of yam slices under different 23 constant relative humidity (RH) and step-down RH levels were studied. A mass transfer model was developed based on Bi-Di correlations containing a drying coefficient and a lag factor to describe the drying process. It was validated using ex...

  20. The Relations between Implicit Intelligence Beliefs, Autonomous Academic Motivation, and School Persistence Intentions: A Mediation Model

    Science.gov (United States)

    Renaud-Dubé, Andréanne; Guay, Frédéric; Talbot, Denis; Taylor, Geneviève; Koestner, Richard

    2015-01-01

    This study attempts to test a model in which the relation between implicit theories of intelligence and students' school persistence intentions are mediated by intrinsic, identified, introjected, and external regulations. Six hundred and fifty students from a high school were surveyed. Contrary to expectations, results from ESEM analyses indicated…

  1. Relations of Transtheoretical Model Stage, Self-Efficacy, and Voluntary Physical Activity in African American Preadolescents

    Science.gov (United States)

    Annesi, James J.; Faigenbaum, Avery D.; Westcott, Wayne L.

    2010-01-01

    The transtheoretical model (TTM; Prochaska, DiClemente, & Norcross, 1992) suggests that, at any point, an individual is in one of five stages-of-change related to adopting a behavior. People sequentially advance in stage but may also maintain or even regress, based on personal and environmental factors (Nigg, 2005). A classic study published in…

  2. Models of Academic Governance and Institutional Power in Southern Baptist Related Liberal Arts Colleges and Universities

    Science.gov (United States)

    Garrison, Michael Shane

    2010-01-01

    The purpose of this descriptive-quantitative study was to examine which models of academic governance are utilized by Southern Baptist related liberal arts colleges and universities. Special attention was given to the distribution of institutional power among seventeen campus leadership groups or power holders. Using J. Victor Baldridge's models…

  3. A CONSOLIDATED MODEL OF ANALYSIS OF THE RELATIONS BETWEEN POLITICS AND MANAGEMENT WITHIN PUBLIC ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    Catalina Maria GEORGESCU

    2011-01-01

    Full Text Available An interdisciplinary approach which combines the theoretical, empirical andconceptual dimensions, the present study tries to offer a new workperspective on the assessment and modeling of the relation between themanagement of public organizations and the political environment. Thetheoretical research was centered on reviewing the literature on the relationbetween the management of public organizations and the politicalenvironment. The empirical research was materialized by modeling with theregression technique of several aspects integrated to the relations betweenthe management of human resources within public organizations in theeducation field and the external political environment.

  4. Significance of predictive models/risk calculators for HBV-related hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    DONG Jing

    2015-06-01

    Full Text Available Hepatitis B virus (HBV-related hepatocellular carcinoma (HCC is a major public health problem in Southeast Asia. In recent years, researchers from Hong Kong and Taiwan have reported predictive models or risk calculators for HBV-associated HCC by studying its natural history, which, to some extent, predicts the possibility of HCC development. Generally, risk factors of each model involve age, sex, HBV DNA level, and liver cirrhosis. This article discusses the evolution and clinical significance of currently used predictive models for HBV-associated HCC and assesses the advantages and limits of risk calculators. Updated REACH-B model and LSM-HCC model show better negative predictive values and have better performance in predicting the outcomes of patients with chronic hepatitis B (CHB. These models can be applied to stratified screening of HCC and, meanwhile, become an assessment tool for the management of CHB patients.

  5. HARMONIC LOAD MODELING: A CASE STUDY OF 33 KV ABUJA ...

    African Journals Online (AJOL)

    HOD

    model spectrum of the feeder under study revealed that the 11th and 13thharmonic orders have the highest percentage of amplitude relative to the ... model spectrum showed that the 14th, 15th, 16th, 17th, 32nd, 33rd and 34thharmonic orders have higher percentage of .... Design/Electromagnetic Transients including DC.

  6. Studying cancer metastasis : Existing models, challenges and future perspectives

    NARCIS (Netherlands)

    van Marion, Denise M. S.; Domanska, Urszula M.; Timmer-Bosscha, Hetty; Walenkamp, Annemiek M. E.

    Cancer metastasis causes most cancer-related deaths. Several model systems to study the complex and multi step process of metastasis exist, including in vitro systems, ex-vivo organ slices, Drosophila Melanogaster and zebrafish models and the use of the chorio allantoic membrane (CAM) of fertilized

  7. Is the demand-control model still a usefull tool to assess work-related psychosocial risk for ischemic heart disease? Results from 14 year follow up in the Copenhagen City Heart study

    DEFF Research Database (Denmark)

    Netterstrøm, Bo; Kristensen, Tage S; Jensen, Gorm

    2010-01-01

    To test the usefulness of the Demand-Control Model as predictor for ischemic heart disease (IHD).......To test the usefulness of the Demand-Control Model as predictor for ischemic heart disease (IHD)....

  8. Animal models for HCV and HBV studies

    Directory of Open Access Journals (Sweden)

    Isabelle Chemin

    2007-02-01

    the infectivity of infectious clones of HCV without chimpanzees. Chimpanzees became infected when RNA transcripts from molecular clones were inoculated directly into the liver. The infection generated by such transfection did not differ significantly from that observed in animals infected intravenously with wild-type HCV. It furthermore permits true homologous challenge in studies of protective immunity and in testing the efficacy of vaccine candidates.

    Finally, this in vivo transfection system has made it possible to test for the first time the importance of genetic elements for HCV infectivity.

    Although chimpanzees are the only animals fully permissive for HBV infection, their use for research purpose is severely limited by the high costs and strong ethical constrains. The only alternative source of HBV-permissive hepatocytes is the Asian tree shrew Tupaia belangeri. Though experimental infection of these squirrel-like mammals, phylogenetically related to primates, results only in a mild, transient replication, primary hepatocytes isolated from T. belangeri turned out to be a reliable tool for in vitro HBV infection experiments.

    Along with invaluable infection studies in chimpanzees, avian and mammalian HBV-related viruses continue to offer ample opportunities for studies in naturally occurring hosts. In general, most of our progresses in hepatitis B virus research are based on infection studies with two HBV-related animal viruses: the woodchuck HBV (WHV, which infects the Eastern American woodchuck (Marmota monax, and the duck HBV (DHBV, which infects Peking ducks. Both animal models have been essential for understanding various steps of viral life-cycle and factors involved in establishment of virus

  9. Models for cooperative games with fuzzy relations among the agents fuzzy communication, proximity relation and fuzzy permission

    CERN Document Server

    Jiménez-Losada, Andrés

    2017-01-01

    This book offers a comprehensive introduction to cooperative game theory and a practice-oriented reference guide to new models and tools for studying bilateral fuzzy relations among several agents or players. It introduces the reader to several fuzzy models, each of which is first analyzed in the context of classical games (crisp games) and subsequently in the context of fuzzy games. Special emphasis is given to the value of Shapley, which is presented for the first time in the context of fuzzy games. Students and researchers will find here a self-contained reference guide to cooperative fuzzy games, characterized by a wealth of examples, descriptions of a wide range of possible situations, step-by-step explanations of the basic mathematical concepts involved, and easy-to-follow information on axioms and properties.

  10. Rumor Propagation Model: An Equilibrium Study

    Directory of Open Access Journals (Sweden)

    José Roberto C. Piqueira

    2010-01-01

    information is analogous phenomena. Here, in an analogy with the SIR (Susceptible-Infected-Removed epidemiological model, the ISS (Ignorant-Spreader-Stifler rumor spreading model is studied. By using concepts from the Dynamical Systems Theory, stability of equilibrium points is established, according to propagation parameters and initial conditions. Some numerical experiments are conducted in order to validate the model.

  11. Geological model of supercritical geothermal reservoir related to subduction system

    Science.gov (United States)

    Tsuchiya, Noriyoshi

    2017-04-01

    C under lithostatic pressures, and then pressures dropped drastically. The solubility of silica also dropped, resulting in formation of quartz veins under a hydrostatic pressure regime. Connections between the lithostatic and hydrostatic pressure regimes were key to the formation of the hydrothermal breccia veins, and the granite-porphyry system provides useful information for creation of fracture clouds in supercritical geothermal reservoirs. A granite-porphyry system, associated with hydrothermal activity and mineralization, provides a suitable natural analog for studying a deep-seated geothermal reservoir where stockwork fracture systems are created in the presence of supercritical geothermal fluids. I describe fracture networks and their formation mechanisms using petrology and fluid inclusion studies in order to understand this "beyond brittle" supercritical geothermal reservoir, and a geological model for "Beyond Brittle" and "Supercritical" geothermal reservoir in the subduction zone were was revealed.

  12. Specific count model for investing the related factors of cost of GERD and functional dyspepsia

    Science.gov (United States)

    Abadi, Alireza; Chaibakhsh, Samira; Safaee, Azadeh; Moghimi-Dehkordi, Bijan

    2013-01-01

    Aim The purpose of this study is to analyze the cost of GERD and functional dyspepsia for investing its related factors. Background Gastro-oesophageal reflux disease GERD and dyspepsia are the most common symptoms of gastrointestinal disorders. Recent studies showed high prevalence and variety of clinical presentation of these two symptoms imposed enormous economic burden to the society. Cost data that related to economics burden have specific characteristics. So this kind of data needs to specific models. Poisson regression (PR) and negative binomial regression (NB) are the models that were used for analyzing cost data in this paper. Patients and methods This study designed as a cross-sectional household survey from May 2006 to December 2007 on a random sample of individual in the Tehran province, Iran to find the prevalence of gastrointestinal symptoms and disorders and its related factors. The Cost in each item was counted. PR and NB were carried out to the data respectively. Likelihood ratio test was performed for comparison between models. Also Log likelihood, Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC) were used to compare performance of the models. Results According to Likelihood ratio test and all three criterions that we used to compare performance of the models, NB was the best model for analyzing this cost data. Sex, age and insurance statues were being significant. Conclusion PR and NB models were carried out for this data and according the results improved fit of the NB model over PR, it clearly indicates that over-dispersion is involved due to unobserved heterogeneity and/or clustering. NB model in cost data more appropriate fit than PR. PMID:24834282

  13. Differential Equations Related to the Williams-Bjerknes Tumour Model

    Indian Academy of Sciences (India)

    Bjerknes tumour model for a cancer which spreads through an epithelial basal layer modeled on ⊂ 2. The solution of this problem is a family =(()), where each () could be considered as an approximation to the probability that the ...

  14. Assessing time-by-covariate interactions in relative survival models using restrictive cubic spline functions.

    Science.gov (United States)

    Bolard, P; Quantin, C; Abrahamowicz, M; Esteve, J; Giorgi, R; Chadha-Boreham, H; Binquet, C; Faivre, J

    2002-01-01

    The Cox model is widely used in the evaluation of prognostic factors in clinical research. However, in population-based studies, which assess long-term survival of unselected populations, relative-survival models are often considered more appropriate. In both approaches, the validity of proportional hazards hypothesis should be evaluated. We propose a new method in which restricted cubic spline functions are employed to model time-by-covariate interactions in relative survival analyses. The method allows investigation of the shape of possible dependence of the covariate effect on time without having to specify a particular functional form. Restricted cubic spline functions allow graphing of such time-by-covariate interactions, to test formally the proportional hazards assumption, and also to test the linearity of the time-by-covariate interaction. Application of our new method to assess mortality in colon cancer provides strong evidence against the proportional hazards hypothesis, which is rejected for all prognostic factors. The results corroborate previous analyses of similar data-sets, suggesting the importance of both modelling of non-proportional hazards and relative survival approach. We also demonstrate the advantages of using restricted cubic spline functions for modelling non-proportional hazards in relative-survival analysis. The results provide new insights in the estimated impact of older age and of period of diagnosis. Using restricted cubic splines in a relative survival model allows the representation of both simple and complex patterns of changes in relative risks over time, with a single parsimonious model without a priori assumptions about the functional form of these changes.

  15. Study of Mothers' Anxieties Related to Their Children's Future

    Science.gov (United States)

    Ilgar, Sengul

    2015-01-01

    The purpose of this study is to study anxieties of mothers related to their children's future. Qualitative method was used in order to study anxieties of mothers from different socio-economic levels. Sample of the study participants are 129 mothers living in Istanbul. 32 of those mothers are from upper socio-economic level, 57, from middle…

  16. QCD and Standard Model Studies

    Energy Technology Data Exchange (ETDEWEB)

    Gagliardi, Carl A [Texas A & M Univ., College Station, TX (United States)

    2017-02-28

    Our group has focused on using jets in STAR to investigate the longitudinal and transverse spin structure of the proton. We performed measurements of the longitudinal double-spin asymmetry for inclusive jet production that provide the strongest evidence to date that the gluons in the proton with x>0.05 are polarized. We also made the first observation of the Collins effect in pp collisions, thereby providing an important test of the universality of the Collins fragmentation function and opening a new tool to probe quark transversity in the proton. Our studies of forward rapidity electromagnetic jet-like events raise serious question whether the large transverse spin asymmetries that have been seen for forward inclusive hadron production arise from conventional 2 → 2 parton scattering. This is the final technical report for DOE Grant DE-FG02-93ER40765. It covers activities during the period January 1, 2015 through November 30, 2016.

  17. Adjusting a cancer mortality-prediction model for disease status-related eligibility criteria

    Directory of Open Access Journals (Sweden)

    Kimmel Marek

    2011-05-01

    Full Text Available Abstract Background Volunteering participants in disease studies tend to be healthier than the general population partially due to specific enrollment criteria. Using modeling to accurately predict outcomes of cohort studies enrolling volunteers requires adjusting for the bias introduced in this way. Here we propose a new method to account for the effect of a specific form of healthy volunteer bias resulting from imposing disease status-related eligibility criteria, on disease-specific mortality, by explicitly modeling the length of the time interval between the moment when the subject becomes ineligible for the study, and the outcome. Methods Using survival time data from 1190 newly diagnosed lung cancer patients at MD Anderson Cancer Center, we model the time from clinical lung cancer diagnosis to death using an exponential distribution to approximate the length of this interval for a study where lung cancer death serves as the outcome. Incorporating this interval into our previously developed lung cancer risk model, we adjust for the effect of disease status-related eligibility criteria in predicting the number of lung cancer deaths in the control arm of CARET. The effect of the adjustment using the MD Anderson-derived approximation is compared to that based on SEER data. Results Using the adjustment developed in conjunction with our existing lung cancer model, we are able to accurately predict the number of lung cancer deaths observed in the control arm of CARET. Conclusions The resulting adjustment was accurate in predicting the lower rates of disease observed in the early years while still maintaining reasonable prediction ability in the later years of the trial. This method could be used to adjust for, or predict the duration and relative effect of any possible biases related to disease-specific eligibility criteria in modeling studies of volunteer-based cohorts.

  18. Studying cancer metastasis: Existing models, challenges and future perspectives.

    Science.gov (United States)

    van Marion, Denise M S; Domanska, Urszula M; Timmer-Bosscha, Hetty; Walenkamp, Annemiek M E

    2016-01-01

    Cancer metastasis causes most cancer-related deaths. Several model systems to study the complex and multi step process of metastasis exist, including in vitro systems, ex-vivo organ slices, Drosophila Melanogaster and zebrafish models and the use of the chorio allantoic membrane (CAM) of fertilized chicken eggs. These models are relatively easy and cheap but often lack the opportunity to study the complete metastasis cascade. More complex but also more expensive is the use of animal models including the more recently developed patient derived tumor xenografts (PDTX). In this review, we give an overview of the existing metastatic models, discuss the challenges of improving current models to enhance translation from the preclinical to the clinical setting and consider future perspectives. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  19. Relating electrophotographic printing model and ISO13660 standard attributes

    Science.gov (United States)

    Barney Smith, Elisa H.

    2010-01-01

    A mathematical model of the electrophotographic printing process has been developed. This model can be used for analysis. From this a print simulation process has been developed to simulate the effects of the model components on toner particle placement. A wide variety of simulated prints are produced from the model's three main inputs, laser spread, charge to toner proportionality factor and toner particle size. While the exact placement of toner particles is a random process, the total effect is not. The effect of each model parameter on the ISO 13660 print quality attributes line width, fill, raggedness and blurriness is described.

  20. An animal model to study regenerative endodontics.

    Science.gov (United States)

    Torabinejad, Mahmoud; Corr, Robert; Buhrley, Matthew; Wright, Kenneth; Shabahang, Shahrokh

    2011-02-01

    A growing body of evidence is demonstrating the possibility for regeneration of tissues within the pulp space and continued root development in teeth with necrotic pulps and open apices. There are areas of research related to regenerative endodontics that need to be investigated in an animal model. The purpose of this study was to investigate ferret cuspid teeth as a model to investigate factors involved in regenerative endodontics. Six young male ferrets between the ages of 36-133 days were used in this investigation. Each animal was anesthetized and perfused with 10% buffered formalin. Block sections including the mandibular and maxillary cuspid teeth and their surrounding periapical tissues were obtained, radiographed, decalcified, sectioned, and stained with hematoxylin-eosin to determine various stages of apical closure in these teeth. The permanent mandibular and maxillary cuspid teeth with open apices erupted approximately 50 days after birth. Initial signs of closure of the apical foramen in these teeth were observed between 90-110 days. Complete apical closure was observed in the cuspid teeth when the animals were 133 days old. Based on the experiment, ferret cuspid teeth can be used to investigate various factors involved in regenerative endodontics that cannot be tested in human subjects. The most appropriate time to conduct the experiments would be when the ferrets are between the ages of 50 and 90 days. Copyright © 2011. Published by Elsevier Inc.

  1. Modeling and Performing Relational Theories in the Classroom

    Science.gov (United States)

    Suter, Elizabeth A.; West, Carrie L.

    2011-01-01

    Although directly related to students' everyday lives, the abstract and even intimidating nature of relational theories often bars students from recognizing the immediate relevance to their relationships. The theories of symbolic interactionism, social exchange, relational dialectics, social penetration, and uncertainty reduction offer students…

  2. Biologically-based mechanistic models of radiation-related carcinogenesis applied to epidemiological data.

    Science.gov (United States)

    Rühm, Werner; Eidemüller, Markus; Kaiser, Jan Christian

    2017-10-01

    Biologically-based mechanistic models that are used in combining current understanding of human carcinogenesis with epidemiological studies were reviewed. Assessment was made of how well they fit the data, whether they account for non-linear radiobiological low-dose effects, and whether they suggest any implications for the dose response at low doses and dose rates. However, the present paper does not make an attempt to provide a complete review of the existing literature on biologically-based models and their application to epidemiological data. In most studies the two-stage clonal expansion (TSCE) model of carcinogenesis was used. The model provided robust estimates of identifiable parameters and radiation risk. While relatively simple, it is flexible, so that more stages can easily be added, and tests made of various types of radiation action. In general, the model performed similarly or better than descriptive excess absolute and excess relative risk models, in terms of quality of fit and number of parameters. Only very rarely the shape of dose-response predicted by the models was investigated. For some tumors, when more detailed biological information was known, additional pathways were included in the model. The future development of these models will benefit from growing knowledge on carcinogenesis processes, and in particular from use of biobank tissue samples and advances in omics technologies. Their use appears a promising approach to investigate the radiation risk at low doses and low dose rates. However, the uncertainties involved are still considerable, and the models provide only a simplified description of the underlying complexity of carcinogenesis. Current assumptions in radiation protection including the linear-non-threshold (LNT) model are not in contradiction to what is presently known on the process of cancer development.

  3. Geospatial Modeling of Asthma Population in Relation to Air Pollution

    Science.gov (United States)

    Kethireddy, Swatantra R.; Tchounwou, Paul B.; Young, John H.; Luvall, Jeffrey C.; Alhamdan, Mohammad

    2013-01-01

    Current observations indicate that asthma is growing every year in the United States, specific reasons for this are not well understood. This study stems from an ongoing research effort to investigate the spatio-temporal behavior of asthma and its relatedness to air pollution. The association between environmental variables such as air quality and asthma related health issues over Mississippi State are investigated using Geographic Information Systems (GIS) tools and applications. Health data concerning asthma obtained from Mississippi State Department of Health (MSDH) for 9-year period of 2003-2011, and data of air pollutant concentrations (PM2.5) collected from USEPA web resources, and are analyzed geospatially to establish the impacts of air quality on human health specifically related to asthma. Disease mapping using geospatial techniques provides valuable insights into the spatial nature, variability, and association of asthma to air pollution. Asthma patient hospitalization data of Mississippi has been analyzed and mapped using quantitative Choropleth techniques in ArcGIS. Patients have been geocoded to their respective zip codes. Potential air pollutant sources of Interstate highways, Industries, and other land use data have been integrated in common geospatial platform to understand their adverse contribution on human health. Existing hospitals and emergency clinics are being injected into analysis to further understand their proximity and easy access to patient locations. At the current level of analysis and understanding, spatial distribution of Asthma is observed in the populations of Zip code regions in gulf coast, along the interstates of south, and in counties of Northeast Mississippi. It is also found that asthma is prevalent in most of the urban population. This GIS based project would be useful to make health risk assessment and provide information support to the administrators and decision makers for establishing satellite clinics in future.

  4. Simultaneous modeling of habitat suitability, occupancy, and relative abundance: African elephants in Zimbabwe

    Science.gov (United States)

    Martin, Julien; Chamaille-Jammes, Simon; Nichols, James D.; Fritz, Herve; Hines, James E.; Fonnesbeck, Christopher J.; MacKenzie, Darryl I.; Bailey, Larissa L.

    2010-01-01

    The recent development of statistical models such as dynamic site occupancy models provides the opportunity to address fairly complex management and conservation problems with relatively simple models. However, surprisingly few empirical studies have simultaneously modeled habitat suitability and occupancy status of organisms over large landscapes for management purposes. Joint modeling of these components is particularly important in the context of management of wild populations, as it provides a more coherent framework to investigate the population dynamics of organisms in space and time for the application of management decision tools. We applied such an approach to the study of water hole use by African elephants in Hwange National Park, Zimbabwe. Here we show how such methodology may be implemented and derive estimates of annual transition probabilities among three dry-season states for water holes: (1) unsuitable state (dry water holes with no elephants); (2) suitable state (water hole with water) with low abundance of elephants; and (3) suitable state with high abundance of elephants. We found that annual rainfall and the number of neighboring water holes influenced the transition probabilities among these three states. Because of an increase in elephant densities in the park during the study period, we also found that transition probabilities from low abundance to high abundance states increased over time. The application of the joint habitat–occupancy models provides a coherent framework to examine how habitat suitability and factors that affect habitat suitability influence the distribution and abundance of organisms. We discuss how these simple models can further be used to apply structured decision-making tools in order to derive decisions that are optimal relative to specified management objectives. The modeling framework presented in this paper should be applicable to a wide range of existing data sets and should help to address important ecological

  5. Simultaneous modeling of habitat suitability, occupancy, and relative abundance: African elephants in Zimbabwe.

    Science.gov (United States)

    Martin, Julien; Chamaillé-Jammes, Simon; Nichols, James D; Fritz, Hervé; Hines, James E; Fonnesbeck, Christopher J; MacKenzie, Darryl I; Bailey, Larissa L

    2010-06-01

    The recent development of statistical models such as dynamic site occupancy models provides the opportunity to address fairly complex management and conservation problems with relatively simple models. However, surprisingly few empirical studies have simultaneously modeled habitat suitability and occupancy status of organisms over large landscapes for management purposes. Joint modeling of these components is particularly important in the context of management of wild populations, as it provides a more coherent framework to investigate the population dynamics of organisms in space and time for the application of management decision tools. We applied such an approach to the study of water hole use by African elephants in Hwange National Park, Zimbabwe. Here we show how such methodology may be implemented and derive estimates of annual transition probabilities among three dry-season states for water holes: (1) unsuitable state (dry water holes with no elephants); (2) suitable state (water hole with water) with low abundance of elephants; and (3) suitable state with high abundance of elephants. We found that annual rainfall and the number of neighboring water holes influenced the transition probabilities among these three states. Because of an increase in elephant densities in the park during the study period, we also found that transition probabilities from low abundance to high abundance states increased over time. The application of the joint habitat-occupancy models provides a coherent framework to examine how habitat suitability and factors that affect habitat suitability influence the distribution and abundance of organisms. We discuss how these simple models can further be used to apply structured decision-making tools in order to derive decisions that are optimal relative to specified management objectives. The modeling framework presented in this paper should be applicable to a wide range of existing data sets and should help to address important ecological

  6. Theory, modeling, and integrated studies in the Arase (ERG) project

    Science.gov (United States)

    Seki, Kanako; Miyoshi, Yoshizumi; Ebihara, Yusuke; Katoh, Yuto; Amano, Takanobu; Saito, Shinji; Shoji, Masafumi; Nakamizo, Aoi; Keika, Kunihiro; Hori, Tomoaki; Nakano, Shin'ya; Watanabe, Shigeto; Kamiya, Kei; Takahashi, Naoko; Omura, Yoshiharu; Nose, Masahito; Fok, Mei-Ching; Tanaka, Takashi; Ieda, Akimasa; Yoshikawa, Akimasa

    2018-02-01

    Understanding of underlying mechanisms of drastic variations of the near-Earth space (geospace) is one of the current focuses of the magnetospheric physics. The science target of the geospace research project Exploration of energization and Radiation in Geospace (ERG) is to understand the geospace variations with a focus on the relativistic electron acceleration and loss processes. In order to achieve the goal, the ERG project consists of the three parts: the Arase (ERG) satellite, ground-based observations, and theory/modeling/integrated studies. The role of theory/modeling/integrated studies part is to promote relevant theoretical and simulation studies as well as integrated data analysis to combine different kinds of observations and modeling. Here we provide technical reports on simulation and empirical models related to the ERG project together with their roles in the integrated studies of dynamic geospace variations. The simulation and empirical models covered include the radial diffusion model of the radiation belt electrons, GEMSIS-RB and RBW models, CIMI model with global MHD simulation REPPU, GEMSIS-RC model, plasmasphere thermosphere model, self-consistent wave-particle interaction simulations (electron hybrid code and ion hybrid code), the ionospheric electric potential (GEMSIS-POT) model, and SuperDARN electric field models with data assimilation. ERG (Arase) science center tools to support integrated studies with various kinds of data are also briefly introduced.[Figure not available: see fulltext.

  7. A Relational Approach to the Study of Religious Survival Units

    DEFF Research Database (Denmark)

    Reeh, Niels

    2012-01-01

    , a religion can be defined and studied as the result of complex set of dynamic relations, where a central tenet of a religion is that it relates to the significant religious other. As such religion is not a stable phenomenon but embedded in a dynamic historical process, which can explain the difficulties...

  8. A Longitudinal Study of Relational and Physical Aggression in Preschool

    Science.gov (United States)

    Crick, Nicki R.; Ostrov, Jamie M.; Burr, Jean E.; Cullerton-Sen, Crystal; Jansen-Yeh, Elizabeth; Ralston, Peter

    2006-01-01

    To understand the development of relational aggression during early childhood, 91 girls and boys ("M" age=39.0; "SD"=7.6 months) and their teachers participated in an 18-month longitudinal study. Children were observed for relational and physical aggression during free play in four time periods. Individually administered interviews were conducted…

  9. Ventriculostomy-related infections--an epidemiological study

    DEFF Research Database (Denmark)

    Stenager, E; Gerner-Smidt, P; Kock-Jensen, C

    1986-01-01

    In a prospective study involving a total of 87 ventriculostomies, ventriculostomy-related infections (based upon a bacteriological definition) developed in 15 patients (17.2 per cent). Intraventricular haemorrhage was related to a higher infection rate. Infection was most frequent within the first...

  10. Graduate Distance Education in Family Relations: A Case Study

    Science.gov (United States)

    Piercy, Kathleen W.; Lee, Thomas R.

    2006-01-01

    This paper discusses graduate distance education in family relations and related disciplines, using a case study approach. Challenges that occur in distance graduate programs are outlined and illustrated by examination of a new master's degree program in Family and Human Development. The program delivers courses by satellite broadcast and…

  11. Modeling spray drift and runoff-related inputs of pesticides to receiving water.

    Science.gov (United States)

    Zhang, Xuyang; Luo, Yuzhou; Goh, Kean S

    2018-03-01

    Pesticides move to surface water via various pathways including surface runoff, spray drift and subsurface flow. Little is known about the relative contributions of surface runoff and spray drift in agricultural watersheds. This study develops a modeling framework to address the contribution of spray drift to the total loadings of pesticides in receiving water bodies. The modeling framework consists of a GIS module for identifying drift potential, the AgDRIFT model for simulating spray drift, and the Soil and Water Assessment Tool (SWAT) for simulating various hydrological and landscape processes including surface runoff and transport of pesticides. The modeling framework was applied on the Orestimba Creek Watershed, California. Monitoring data collected from daily samples were used for model evaluation. Pesticide mass deposition on the Orestimba Creek ranged from 0.08 to 6.09% of applied mass. Monitoring data suggests that surface runoff was the major pathway for pesticide entering water bodies, accounting for 76% of the annual loading; the rest 24% from spray drift. The results from the modeling framework showed 81 and 19%, respectively, for runoff and spray drift. Spray drift contributed over half of the mass loading during summer months. The slightly lower spray drift contribution as predicted by the modeling framework was mainly due to SWAT's under-prediction of pesticide mass loading during summer and over-prediction of the loading during winter. Although model simulations were associated with various sources of uncertainties, the overall performance of the modeling framework was satisfactory as evaluated by multiple statistics: for simulation of daily flow, the Nash-Sutcliffe Efficiency Coefficient (NSE) ranged from 0.61 to 0.74 and the percent bias (PBIAS) modeling framework will be useful for assessing the relative exposure from pesticides related to spray drift and runoff in receiving waters and the design of management practices for mitigating pesticide

  12. Abrasive slurry jet cutting model based on fuzzy relations

    Science.gov (United States)

    Qiang, C. H.; Guo, C. W.

    2017-12-01

    The cutting process of pre-mixed abrasive slurry or suspension jet (ASJ) is a complex process affected by many factors, and there is a highly nonlinear relationship between the cutting parameters and cutting quality. In this paper, guided by fuzzy theory, the fuzzy cutting model of ASJ was developed. In the modeling of surface roughness, the upper surface roughness prediction model and the lower surface roughness prediction model were established respectively. The adaptive fuzzy inference system combines the learning mechanism of neural networks and the linguistic reasoning ability of the fuzzy system, membership functions, and fuzzy rules are obtained by adaptive adjustment. Therefore, the modeling process is fast and effective. In this paper, the ANFIS module of MATLAB fuzzy logic toolbox was used to establish the fuzzy cutting model of ASJ, which is found to be quite instrumental to ASJ cutting applications.

  13. Trend of environmental radiation protection and its current related studies

    International Nuclear Information System (INIS)

    Yoshida, Satoshi

    2011-01-01

    Reviewed are the international trend of environmental radiation protection (ERP), Japanese studies of radiation effects on environmental livings from aspects of ecosystem to molecular level, and the future view. ERP is particularly closed up toward promotion after its first involvement in the general global conference, UN Conference on Environment and Development (1992). International Commission of Radiological Protection (ICRP) has conducted such actions for the environment as establishing protection essentials for non-human species (2003), organizing Committee 5 (2005), and defining Reference Animals and Plants (2008) where Derived Consideration Reference Levels of 0.1-100 mGy/d are proposed, together with cooperative actions by United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), International Atomic Energy Agency (IAEA), The Organization for Economic Co-operation and Development (OECD)/Nuclear Energy Agency (NEA) and European projects. Japanese NIRS is now enrolled in the project of Environmental Modeling for Radiation Safety-II (IAEA). Major Japanese studies of radiation effects on environmental livings have utilized killifish (medaka: Oryzias latipes), springtail, earthworm, nematode, cultured plant cell (cedar), poplar, etc. Studies of the radiation effect on microcosm consisting of 3 livings have led to establishing a model for mathematical analysis and of 8 livings, have defined 50% affect dose of 5600 Gy gamma-ray. Irradiation of gamma-ray at 1 Gy/d for 5-10 days to the soil has been shown to result in alteration of the composition of natural earth bacterial population by denaturant gradient gel electrophoresis, which being a promising tool for evaluating the alteration of soil composition and function. At molecular levels, transcriptome analysis of various cells from yeast to man, is performed after irradiation of gamma-ray, neutron, heavy particles and others to reveal radiation-induced gene expression; and Hi-CEP (high

  14. Study finds increases in risk of leukemias related to treatment

    Science.gov (United States)

    A new study describes the pattern of risk for chemotherapy-related acute myeloid leukemia among adult cancer survivors over the past three decades who have previously been treated with chemotherapy for other cancers. These patterns coincide with major shi

  15. Chemical equilibrium relations used in the fireball model of relativistic heavy ion reactions

    International Nuclear Information System (INIS)

    Gupta, S.D.

    1978-01-01

    The fireball model of relativistic heavy-ion collision uses chemical equilibrium relations to predict cross sections for particle and composite productions. These relations are examined in a canonical ensemble model where chemical equilibrium is not explicitly invoked

  16. Developmental Relational Counseling: A Model for Self-Understanding in Relation to Others

    Science.gov (United States)

    Duffey, Thelma; Haberstroh, Shane

    2012-01-01

    Developmental relational counseling (DRC) is an integrative framework designed to help clients develop personal awareness and relational functioning and conceptualize personal growth. DRC emerged from both authors' clinical work and was significantly influenced by relational-cultural theory and guided by the Enneagram personality typology and…

  17. Are study strategies related to medical licensing exam performance?

    Science.gov (United States)

    West, Courtney; Kurz, Terri; Smith, Sherry; Graham, Lori

    2014-11-02

    To examine the relationship between study strategies and performance on a high stakes medical licensing exam entitled the United States Medical Licensing Examination Step 1. The action research project included seventy nine student participants at the Texas A & M Health Science Center College of Medicine during their pre-clinical education. Data collection included pre-matriculation and matriculation academic performance data, standardized exam data, and the Learning and Study Strategies Instrument. Multiple regression analyses were conducted. For both models, the dependent variable was the Step 1 score, and the independent variables included Medical College Admission Test, Undergraduate Grade Point Average, Year 1 Average, Year 2 Average, Customized National Board of Medical Examiners Average, Comprehensive Basic Science Exam score, and Learning and Study Strategy Instrument sub-scores. Model 2 added Comprehensive Basic Science Self-Assessment average. Concentration (Model 1 - β = .264; Model 2 - β = .254) was the only study strategy correlated with Step 1 performance. The other statistically significant predictors were Customized National Board of Medical Examiners Average (β = .315) and Year 2 Average (β = .280) in Model 1 and Comprehensive Basic Science Self-Assessment Average (β = .338) in Model 2. There does appear to be a relationship between the study strategy concentration and Step 1 licensing exam performance. Teaching students to practice and utilize certain techniques to improve concentration skills when preparing for and taking exams may help improve licensing exam scores.

  18. IRI related data and model services at NSSDC

    Science.gov (United States)

    Bilitza, D.; Papitashvili, N.; King, J.

    NASA's National Space Science Data Center (NSSDC) provides internet access to a large number of space physics data sets and models. We will review and explain the different products and services that might be of interest to the IRI community. Data can be obtained directly through anonymous ftp or through the SPyCAT WWW interface to a large volume of space physics data on juke-box type mass storage devices. A newly developed WWW system, the ATMOWeb, provides browse and sub-setting capabilities for selected atmospheric and thermospheric data. NSSDC maintains an archive of space physics models that includes a subset of ionospheric models. The model software can be retrieved via anonymous ftp. A selection of the most frequently requested models can be run on-line through special WWW interfaces. Currently supported models include the International Reference Ionosphere (IRI), the Mass Spectrometer and Incoherent Scatter (MSIS) atmospheric model, the International Geomagnetic Reference Field (IGRF) and the AE-8/AP-8 radiation belt models. In this article special emphasis will be given to the IRI interface and its various input/output options. Several new options and a Java-based plotting capability were recently added to the Web interface.

  19. Design and validation of a relative trust model

    NARCIS (Netherlands)

    Hoogendoorn, M.; Jaffry, S.W.; Maanen, P.P. van; Treur, J.

    2014-01-01

    When considering intelligent agents that interact with humans, having an idea of the trust levels of the human, for example in other agents or services, can be of great importance. Most models of human trust that exist assume trust in one trustee is independent of trust in another trustee. The model

  20. Modelling situation awareness relations in a multiagent system

    NARCIS (Netherlands)

    Blom, H.A.P.; Sharpanskykh, A.

    2015-01-01

    There is broad consensus that situation awareness (SA) plays a key role in agent-based modelling of complex sociotechnical systems. However in the social sciences and human factors literature there are different views on what SA is and how it could be modelled. More specifically, one school of

  1. How to: understanding SWAT model uncertainty relative to measured results

    Science.gov (United States)

    Watershed models are being relied upon to contribute to most policy-making decisions of watershed management, and the demand for an accurate accounting of complete model uncertainty is rising. Generalized likelihood uncertainty estimation (GLUE) is a widely used method for quantifying uncertainty i...

  2. A SYSTEMATIC STUDY OF SOFTWARE QUALITY MODELS

    OpenAIRE

    Dr.Vilas. M. Thakare; Ashwin B. Tomar

    2011-01-01

    This paper aims to provide a basis for software quality model research, through a systematic study ofpapers. It identifies nearly seventy software quality research papers from journals and classifies paper asper research topic, estimation approach, study context and data set. The paper results combined withother knowledge provides support for recommendations in future software quality model research, toincrease the area of search for relevant studies, carefully select the papers within a set ...

  3. Longitudinal beta regression models for analyzing health-related quality of life scores over time

    Directory of Open Access Journals (Sweden)

    Hunger Matthias

    2012-09-01

    Full Text Available Abstract Background Health-related quality of life (HRQL has become an increasingly important outcome parameter in clinical trials and epidemiological research. HRQL scores are typically bounded at both ends of the scale and often highly skewed. Several regression techniques have been proposed to model such data in cross-sectional studies, however, methods applicable in longitudinal research are less well researched. This study examined the use of beta regression models for analyzing longitudinal HRQL data using two empirical examples with distributional features typically encountered in practice. Methods We used SF-6D utility data from a German older age cohort study and stroke-specific HRQL data from a randomized controlled trial. We described the conceptual differences between mixed and marginal beta regression models and compared both models to the commonly used linear mixed model in terms of overall fit and predictive accuracy. Results At any measurement time, the beta distribution fitted the SF-6D utility data and stroke-specific HRQL data better than the normal distribution. The mixed beta model showed better likelihood-based fit statistics than the linear mixed model and respected the boundedness of the outcome variable. However, it tended to underestimate the true mean at the upper part of the distribution. Adjusted group means from marginal beta model and linear mixed model were nearly identical but differences could be observed with respect to standard errors. Conclusions Understanding the conceptual differences between mixed and marginal beta regression models is important for their proper use in the analysis of longitudinal HRQL data. Beta regression fits the typical distribution of HRQL data better than linear mixed models, however, if focus is on estimating group mean scores rather than making individual predictions, the two methods might not differ substantially.

  4. Modified Dugdale crack models - some easy crack relations

    DEFF Research Database (Denmark)

    Nielsen, Lauge Fuglsang

    1997-01-01

    The Dugdale crack model is widely used in materials science to predict strength of defective (cracked) materials. A stable Dugdale crack in an elasto-plastic material is prevented from spreading by uniformly distributed cohesive stresses acting in narrow areas at the crack tips. These stresses...... are assumed to be self created by local materials flow. The strength sigma_CR predictid by the Dugdale model is sigma_CR =(E Gamma_CR/phi1)^½ where E and 1 are Young’s modulus and crack half-length respectively of the material considered. The so-called critical strain energy rate is Gamma_CR = sigma......) by a constant flow stress (sigma_L). A number of materials, however, do not at all exhibit this kind of flow. Such materials are considered in this paper by Modified Dugdale crack models which apply for any cohesive stress distribution in crack front areas. Formally modified Dugdale crack models exhibit...

  5. Corruption model of loss propagation for relative prioritized packet video

    Science.gov (United States)

    Kim, Jin-Gyeong; Kim, JongWon; Kuo, C.-C. Jay

    2000-12-01

    Several analytical models have been recently introduced to estimate the impact of the error propagation effect on the source video caused by lossy transmission channels. However, previous work focused either on the statistical aspects for the whole sequence or had a high computational complexity. In this work, we concentrate on estimating the distortion caused by the loss of a packet with a moderate computational complexity. The proposed model considers both the spatial filtering effect and the temporal dependency that affect the error propagation behavior. To verify this model, a real loss propagation effect is measured and compared with that of the expected distortion level derived by the model. Also, its applicability to the quality of service (QoS) of transmitted video is demonstrated through the packet video evaluation over the simulated differentiated service (DiffServ) forwarding mechanism.

  6. Integration of hydrothermal-energy economics: related quantitative studies

    Energy Technology Data Exchange (ETDEWEB)

    1982-08-01

    A comparison of ten models for computing the cost of hydrothermal energy is presented. This comparison involved a detailed examination of a number of technical and economic parameters of the various quantitative models with the objective of identifying the most important parameters in the context of accurate estimates of cost of hydrothermal energy. Important features of various models, such as focus of study, applications, marked sectors covered, methodology, input data requirements, and output are compared in the document. A detailed sensitivity analysis of all the important engineering and economic parameters is carried out to determine the effect of non-consideration of individual parameters.

  7. Boundary layer studies related to fusion theory. Final report

    International Nuclear Information System (INIS)

    1981-01-01

    The described work studied the boundary between closed and open field lines in EBT geometry, with emphasis on the microstability properties. These properties were established primarily for drift waves in the lower hybrid range of frequencies. The transport due to these modes was evaluated by a self-consistent treatment, using quasilinear models in a plasma diffusion code. The model was benchmarked against the EDT experimental results from ORNL and the sensitivity to transport model established. Viscosity was estimated to be negligible compared with anomalous transport. Drift wave turbulence gave a boundary layer size much more consistent with experiment than either collisional transport or Bohm diffusion

  8. A Study of Simple Diffraction Models

    DEFF Research Database (Denmark)

    Agerkvist, Finn

    In this paper two simple methods for cabinet edge diffraction are examined. Calculations with both models are compared with more sophisticated theoretical models and with measured data. The parameters involved are studied and their importance for normal loudspeaker box designs is examined....

  9. Using mixture models to characterize disease-related traits

    OpenAIRE

    Ye Kenny Q; Chase Gary A; Finch Stephen J; Duan Tao; Mendell Nancy R

    2005-01-01

    Abstract We consider 12 event-related potentials and one electroencephalogram measure as disease-related traits to compare alcohol-dependent individuals (cases) to unaffected individuals (controls). We use two approaches: 1) two-way analysis of variance (with sex and alcohol dependency as the factors), and 2) likelihood ratio tests comparing sex adjusted values of cases to controls assuming that within each group the trait has a 2 (or 3) component normal mixture distribution. In the second ap...

  10. Synthetic event-related potentials: a computational bridge between neurolinguistic models and experiments.

    Science.gov (United States)

    Barrès, Victor; Simons, Arthur; Arbib, Michael

    2013-01-01

    Our previous work developed Synthetic Brain Imaging to link neural and schema network models of cognition and behavior to PET and fMRI studies of brain function. We here extend this approach to Synthetic Event-Related Potentials (Synthetic ERP). Although the method is of general applicability, we focus on ERP correlates of language processing in the human brain. The method has two components: Phase 1: To generate cortical electro-magnetic source activity from neural or schema network models; and Phase 2: To generate known neurolinguistic ERP data (ERP scalp voltage topographies and waveforms) from putative cortical source distributions and activities within a realistic anatomical model of the human brain and head. To illustrate the challenges of Phase 2 of the methodology, spatiotemporal information from Friederici's 2002 model of auditory language comprehension was used to define cortical regions and time courses of activation for implementation within a forward model of ERP data. The cortical regions from the 2002 model were modeled using atlas-based masks overlaid on the MNI high definition single subject cortical mesh. The electromagnetic contribution of each region was modeled using current dipoles whose position and orientation were constrained by the cortical geometry. In linking neural network computation via EEG forward modeling to empirical results in neurolinguistics, we emphasize the need for neural network models to link their architecture to geometrically sound models of the cortical surface, and the need for conceptual models to refine and adopt brain-atlas based approaches to allow precise brain anchoring of their modules. The detailed analysis of Phase 2 sets the stage for a brief introduction to Phase 1 of the program, including the case for a schema-theoretic approach to language production and perception presented in detail elsewhere. Unlike Dynamic Causal Modeling (DCM) and Bojak's mean field model, Synthetic ERP builds on models of networks

  11. Multivariate analysis of the population representativeness of related clinical studies.

    Science.gov (United States)

    He, Zhe; Ryan, Patrick; Hoxha, Julia; Wang, Shuang; Carini, Simona; Sim, Ida; Weng, Chunhua

    2016-04-01

    To develop a multivariate method for quantifying the population representativeness across related clinical studies and a computational method for identifying and characterizing underrepresented subgroups in clinical studies. We extended a published metric named Generalizability Index for Study Traits (GIST) to include multiple study traits for quantifying the population representativeness of a set of related studies by assuming the independence and equal importance among all study traits. On this basis, we compared the effectiveness of GIST and multivariate GIST (mGIST) qualitatively. We further developed an algorithm called "Multivariate Underrepresented Subgroup Identification" (MAGIC) for constructing optimal combinations of distinct value intervals of multiple traits to define underrepresented subgroups in a set of related studies. Using Type 2 diabetes mellitus (T2DM) as an example, we identified and extracted frequently used quantitative eligibility criteria variables in a set of clinical studies. We profiled the T2DM target population using the National Health and Nutrition Examination Survey (NHANES) data. According to the mGIST scores for four example variables, i.e., age, HbA1c, BMI, and gender, the included observational T2DM studies had superior population representativeness than the interventional T2DM studies. For the interventional T2DM studies, Phase I trials had better population representativeness than Phase III trials. People at least 65years old with HbA1c value between 5.7% and 7.2% were particularly underrepresented in the included T2DM trials. These results confirmed well-known knowledge and demonstrated the effectiveness of our methods in population representativeness assessment. mGIST is effective at quantifying population representativeness of related clinical studies using multiple numeric study traits. MAGIC identifies underrepresented subgroups in clinical studies. Both data-driven methods can be used to improve the transparency of

  12. Pediatric health-related quality of life: a structural equation modeling approach.

    Directory of Open Access Journals (Sweden)

    Ester Villalonga-Olives

    Full Text Available OBJECTIVES: One of the most referenced theoretical frameworks to measure Health Related Quality of Life (HRQoL is the Wilson and Cleary framework. With some adaptions this framework has been validated in the adult population, but has not been tested in pediatric populations. Our goal was to empirically investigate it in children. METHODS: The contributory factors to Health Related Quality of Life that we included were symptom status (presence of chronic disease or hospitalizations, functional status (developmental status, developmental aspects of the individual (social-emotional behavior, and characteristics of the social environment (socioeconomic status and area of education. Structural equation modeling was used to assess the measurement structure of the model in 214 German children (3-5 years old participating in a follow-up study that investigates pediatric health outcomes. RESULTS: Model fit was χ2 = 5.5; df = 6; p = 0.48; SRMR  = 0.01. The variance explained of Health Related Quality of Life was 15%. Health Related Quality of Life was affected by the area education (i.e. where kindergartens were located and development status. Developmental status was affected by the area of education, socioeconomic status and individual behavior. Symptoms did not affect the model. CONCLUSIONS: The goodness of fit and the overall variance explained were good. However, the results between children' and adults' tests differed and denote a conceptual gap between adult and children measures. Indeed, there is a lot of variety in pediatric Health Related Quality of Life measures, which represents a lack of a common definition of pediatric Health Related Quality of Life. We recommend that researchers invest time in the development of pediatric Health Related Quality of Life theory and theory based evaluations.

  13. Pediatric health-related quality of life: a structural equation modeling approach.

    Science.gov (United States)

    Villalonga-Olives, Ester; Kawachi, Ichiro; Almansa, Josué; Witte, Claudia; Lange, Benjamin; Kiese-Himmel, Christiane; von Steinbüchel, Nicole

    2014-01-01

    One of the most referenced theoretical frameworks to measure Health Related Quality of Life (HRQoL) is the Wilson and Cleary framework. With some adaptions this framework has been validated in the adult population, but has not been tested in pediatric populations. Our goal was to empirically investigate it in children. The contributory factors to Health Related Quality of Life that we included were symptom status (presence of chronic disease or hospitalizations), functional status (developmental status), developmental aspects of the individual (social-emotional) behavior, and characteristics of the social environment (socioeconomic status and area of education). Structural equation modeling was used to assess the measurement structure of the model in 214 German children (3-5 years old) participating in a follow-up study that investigates pediatric health outcomes. Model fit was χ2 = 5.5; df = 6; p = 0.48; SRMR  = 0.01. The variance explained of Health Related Quality of Life was 15%. Health Related Quality of Life was affected by the area education (i.e. where kindergartens were located) and development status. Developmental status was affected by the area of education, socioeconomic status and individual behavior. Symptoms did not affect the model. The goodness of fit and the overall variance explained were good. However, the results between children' and adults' tests differed and denote a conceptual gap between adult and children measures. Indeed, there is a lot of variety in pediatric Health Related Quality of Life measures, which represents a lack of a common definition of pediatric Health Related Quality of Life. We recommend that researchers invest time in the development of pediatric Health Related Quality of Life theory and theory based evaluations.

  14. Study on sociological approach to resolve maintenance related social problems

    International Nuclear Information System (INIS)

    Aoki, Takayuki

    2007-01-01

    This study proposes a sociological approach to resolve maintenance related social problems. As a result of consideration, the followings were found. (1) In general, solutions to some kinds of questions can be deduced from basic laws using some theories or methodologies in the field of the natural science or engineering. The approach to resolve maintenance related social problems is similar to the approach in the natural science or engineering. (2) The points of view based on fundamental human rights, market principles and community principles, and so on, are very important in resolving maintenance related social problems and can be placed as theories or tools for resolution. (3) If such theories or tools for resolving maintenance related social problems as described above are systematically prepared, it is estimated that it becomes very much easier to resolve maintenance related social problems. (author)

  15. An Ionospheric Metric Study Using Operational Models

    Science.gov (United States)

    Sojka, J. J.; Schunk, R. W.; Thompson, D. C.; Scherliess, L.; Harris, T. J.

    2006-12-01

    One of the outstanding challenges in upgrading ionospheric operational models is quantifying their improvement. This challenge is not necessarily an absolute accuracy one, but rather answering the question, "Is the newest operational model an improvement over its predecessor under operational scenarios?" There are few documented cases where ionospheric models are compared either with each other or against "ground truth". For example a CEDAR workshop team, PRIMO, spent almost a decade carrying out a models comparison with ionosonde and incoherent scatter radar measurements from the Millstone Hill, Massachusetts location [Anderson et al.,1998]. The result of this study was that all models were different and specific conditions could be found when each was the "best" model. Similarly, a National Space Weather Metrics ionospheric challenge was held and results were presented at a National Space Weather meeting. The results were again found to be open to interpretation, and issues with the value of the specific metrics were raised (Fuller-Rowell, private communication, 2003). Hence, unlike the tropospheric weather community, who have established metrics and exercised them on new models over many decades to quantify improvement, the ionospheric community has not yet settled on a metric of both scientific and operational value. We report on a study in which metrics were used to compare various forms of the International Reference Ionosphere (IRI), the Ionospheric Forecast Model (IFM), and the Utah State University Global Assimilation of Ionospheric Measurements Model (USU-GAIM) models. The ground truth for this study was a group of 11 ionosonde data sets taken between 20 March and 19 April 2004. The metric parameter was the ionosphere's critical frequency. The metric was referenced to the IRI. Hence, the study addressed the specific question what improvement does IFM and USU-GAIM have over IRI. Both strengths (improvements) and weaknesses of these models are discussed

  16. Extended Nambu models: Their relation to gauge theories

    Science.gov (United States)

    Escobar, C. A.; Urrutia, L. F.

    2017-05-01

    Yang-Mills theories supplemented by an additional coordinate constraint, which is solved and substituted in the original Lagrangian, provide examples of the so-called Nambu models, in the case where such constraints arise from spontaneous Lorentz symmetry breaking. Some explicit calculations have shown that, after additional conditions are imposed, Nambu models are capable of reproducing the original gauge theories, thus making Lorentz violation unobservable and allowing the interpretation of the corresponding massless gauge bosons as the Goldstone bosons arising from the spontaneous symmetry breaking. A natural question posed by this approach in the realm of gauge theories is to determine under which conditions the recovery of an arbitrary gauge theory from the corresponding Nambu model, defined by a general constraint over the coordinates, becomes possible. We refer to these theories as extended Nambu models (ENM) and emphasize the fact that the defining coordinate constraint is not treated as a standard gauge fixing term. At this level, the mechanism for generating the constraint is irrelevant and the case of spontaneous Lorentz symmetry breaking is taken only as a motivation, which naturally bring this problem under consideration. Using a nonperturbative Hamiltonian analysis we prove that the ENM yields the original gauge theory after we demand current conservation for all time, together with the imposition of the Gauss laws constraints as initial conditions upon the dynamics of the ENM. The Nambu models yielding electrodynamics, Yang-Mills theories and linearized gravity are particular examples of our general approach.

  17. Modelling aerosol processes related to the atmospheric dispersion of sarin.

    Science.gov (United States)

    Kukkonen, J; Riikonen, K; Nikmo, J; Jäppinen, A; Nieminen, K

    2001-08-17

    We have developed mathematical models for evaluating the atmospheric dispersion of selected chemical warfare agents (CWA), including the evaporation and settling of contaminant liquid droplets. The models and numerical results presented may be utilised for designing protection and control measures against the conceivable use of CWA's. The model AERCLOUD (AERosol CLOUD) was extended to treat two nerve agents, sarin and VX, and the mustard agent. This model evaluates the thermodynamical evolution of a five-component aerosol mixture, consisting of two-component droplets together with the surrounding three-component gas. We have performed numerical computations with this model on the evaporation and settling of airborne sarin droplets in characteristic dispersal and atmospheric conditions. In particular, we have evaluated the maximum radii (r(M)) of a totally evaporating droplet, in terms of the ambient temperature and contaminant vapour concentration. The radii r(M) range from approximately 15-80 microm for sarin droplets for the selected ambient conditions and initial heights. We have also evaluated deposition fractions in terms of the initial droplet size.

  18. Statistical Modelling of Temperature and Moisture Uptake of Biochars Exposed to Selected Relative Humidity of Air.

    Science.gov (United States)

    Bastistella, Luciane; Rousset, Patrick; Aviz, Antonio; Caldeira-Pires, Armando; Humbert, Gilles; Nogueira, Manoel

    2018-02-09

    New experimental techniques, as well as modern variants on known methods, have recently been employed to investigate the fundamental reactions underlying the oxidation of biochar. The purpose of this paper was to experimentally and statistically study how the relative humidity of air, mass, and particle size of four biochars influenced the adsorption of water and the increase in temperature. A random factorial design was employed using the intuitive statistical software Xlstat. A simple linear regression model and an analysis of variance with a pairwise comparison were performed. The experimental study was carried out on the wood of Quercus pubescens , Cyclobalanopsis glauca , Trigonostemon huangmosun , and Bambusa vulgaris , and involved five relative humidity conditions (22, 43, 75, 84, and 90%), two mass samples (0.1 and 1 g), and two particle sizes (powder and piece). Two response variables including water adsorption and temperature increase were analyzed and discussed. The temperature did not increase linearly with the adsorption of water. Temperature was modeled by nine explanatory variables, while water adsorption was modeled by eight. Five variables, including factors and their interactions, were found to be common to the two models. Sample mass and relative humidity influenced the two qualitative variables, while particle size and biochar type only influenced the temperature.

  19. Statistical Modelling of Temperature and Moisture Uptake of Biochars Exposed to Selected Relative Humidity of Air

    Directory of Open Access Journals (Sweden)

    Luciane Bastistella

    2018-02-01

    Full Text Available New experimental techniques, as well as modern variants on known methods, have recently been employed to investigate the fundamental reactions underlying the oxidation of biochar. The purpose of this paper was to experimentally and statistically study how the relative humidity of air, mass, and particle size of four biochars influenced the adsorption of water and the increase in temperature. A random factorial design was employed using the intuitive statistical software Xlstat. A simple linear regression model and an analysis of variance with a pairwise comparison were performed. The experimental study was carried out on the wood of Quercus pubescens, Cyclobalanopsis glauca, Trigonostemon huangmosun, and Bambusa vulgaris, and involved five relative humidity conditions (22, 43, 75, 84, and 90%, two mass samples (0.1 and 1 g, and two particle sizes (powder and piece. Two response variables including water adsorption and temperature increase were analyzed and discussed. The temperature did not increase linearly with the adsorption of water. Temperature was modeled by nine explanatory variables, while water adsorption was modeled by eight. Five variables, including factors and their interactions, were found to be common to the two models. Sample mass and relative humidity influenced the two qualitative variables, while particle size and biochar type only influenced the temperature.

  20. Analysis of air temperature and relative humidity: study of microclimates

    OpenAIRE

    Elis Dener Lima Alves; Marcelo Sacardi Biudes

    2012-01-01

    Understanding the variability of climate elements in time and space is fundamental to the knowledge of the dynamics of microclimate. Thus, the objective was to analyze the variability of air temperature and relative humidity on the Cuiabá campus of the Federal University of Mato Grosso, and, through the clustering technique, to analyze the formation of groups to propose a zoning microclimate in the area study. To this end, collection data of air temperature and relative humidity at 15 points ...

  1. Central Venous Catheter (CVC) related infections: a local retrospective study

    OpenAIRE

    Manuela Fresu; Agostina Ronca; Carla Pruzzo; Simona Roveta

    2008-01-01

    Background. Central venous catheter (CVC) related infection is associated with significant increases in morbidity, mortality, and health care cost.This local surveillance study was carry out to monitor the frequency of occurrence of CVC-related blood stream infections. Materials and methods. During the period January – December 2005, 226 CVC specimens were analyzed (quantitative method) and microrganism identification from positive samples was performed by Vitek II. In 53 patients it was poss...

  2. REELIN-RELATED DISTURBANCES IN DEPRESSION: IMPLICATIONS FOR TRANSLATIONAL STUDIES

    Directory of Open Access Journals (Sweden)

    Hector J eCaruncho

    2016-02-01

    Full Text Available The finding that reelin expression is significantly decreased in mood and psychotic disorders, together with evidence that reelin can regulate key aspects of hippocampal plasticity in the adult brain, brought our research group and others to study the possible role of reelin in the pathogenesis of depression. This review describes recent progress on this topic using an animal model of depression that makes use of repeated corticosterone injections. This methodology produces depression-like symptoms in both rats and mice that are reversed by antidepressant treatment. We have reported that corticosterone causes a decrease in the number of reelin-immunopositive cells in the dentate gyrus subgranular zone, where adult hippocampal neurogenesis takes place; that down-regulation of the number of reelin-positive cells closely parallels the development of a depression-like phenotype during repeated corticosterone treatment; that reelin downregulation alters the co-expression of reelin with neuronal nitric oxide synthase; that deficits in reelin might also create imbalances in glutamatergic and GABAergic circuits within the hippocampus and other limbic structures; and that co-treatment with antidepressant drugs prevents both reelin deficits and the development of a depression-like phenotype. We also observed alterations in the pattern of membrane protein clustering in peripheral lymphocytes in animals with low levels of reelin. Importantly, we found parallel changes in membrane protein clustering in depression patients, which differentiated two subpopulations of naïve depression patients that showed a different therapeutic response to antidepressant treatment. Here we review these findings and develop the hypothesis that restoring reelin-related function could represent a novel approach for antidepressant therapies.

  3. Thymoma related myasthenia gravis in humans and potential animal models.

    Science.gov (United States)

    Marx, Alexander; Porubsky, Stefan; Belharazem, Djeda; Saruhan-Direskeneli, Güher; Schalke, Berthold; Ströbel, Philipp; Weis, Cleo-Aron

    2015-08-01

    Thymoma-associated Myasthenia gravis (TAMG) is one of the anti-acetylcholine receptor MG (AChR-MG) subtypes. The clinico-pathological features of TAMG and its pathogenesis are described here in comparison with pathogenetic models suggested for the more common non-thymoma AChR-MG subtypes, early onset MG and late onset MG. Emphasis is put on the role of abnormal intratumorous T cell selection and activation, lack of intratumorous myoid cells and regulatory T cells as well as deficient expression of the autoimmune regulator (AIRE) by neoplastic thymic epithelial cells. We review spontaneous and genetically engineered thymoma models in a spectrum of animals and the extensive clinical and immunological overlap between canine, feline and human TAMG. Finally, limitations and perspectives of the transplantation of human and murine thymoma tissue into nude mice, as potential models for TAMG, are addressed. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Molecular genetic models related to schizophrenia and psychotic illness: heuristics and challenges.

    Science.gov (United States)

    O'Tuathaigh, Colm M P; Desbonnet, Lieve; Moran, Paula M; Kirby, Brian P; Waddington, John L

    2011-01-01

    Schizophrenia is a heritable disorder that may involve several common genes of small effect and/or rare copy number variation, with phenotypic heterogeneity across patients. Furthermore, any boundaries vis-à-vis other psychotic disorders are far from clear. Consequently, identification of informative animal models for this disorder, which typically relate to pharmacological and putative pathophysiological processes of uncertain validity, faces considerable challenges. In juxtaposition, the majority of mutant models for schizophrenia relate to the functional roles of a diverse set of genes associated with risk for the disorder or with such putative pathophysiological processes. This chapter seeks to outline the evidence from phenotypic studies in mutant models related to schizophrenia. These have commonly assessed the degree to which mutation of a schizophrenia-related gene is associated with the expression of several aspects of the schizophrenia phenotype or more circumscribed, schizophrenia-related endophenotypes; typically, they place specific emphasis on positive and negative symptoms and cognitive deficits, and extend to structural and other pathological features. We first consider the primary technological approaches to the generation of such mutants, to include their relative merits and demerits, and then highlight the diverse phenotypic approaches that have been developed for their assessment. The chapter then considers the application of mutant phenotypes to study pathobiological and pharmacological mechanisms thought to be relevant for schizophrenia, particularly in terms of dopaminergic and glutamatergic dysfunction, and to an increasing range of candidate susceptibility genes and copy number variants. Finally, we discuss several pertinent issues and challenges within the field which relate to both phenotypic evaluation and a growing appreciation of the functional genomics of schizophrenia and the involvement of gene × environment interactions.

  5. Bacteriophage therapy in implant-related infections: an experimental study.

    Science.gov (United States)

    Yilmaz, Cengiz; Colak, Mehmet; Yilmaz, Banu Coskun; Ersoz, Gulden; Kutateladze, Mzia; Gozlugol, Mehmet

    2013-01-16

    Implant-related infections with bacteria resistant to multiple antibiotics represent one of the major problems in orthopaedic surgery. It was our hypothesis that local application of bacteriophages, which are bacteria-destroying viruses, would be effective against biofilm-forming bacteria. An implant-related infection model was created using methicillin-resistant Staphylococcus aureus (MRSA) in forty-eight rats and Pseudomonas aeruginosa in another forty-eight rats. Each group was divided into four subgroups; one subgroup received a bacterium-specific bacteriophage (Sb-1 in the MRSA group and PAT14 in the Pseudomonas aeruginosa group), one received antibiotic for fourteen days (20 mg/kg/day teicoplanin in the MRSA group, and 120 mg/kg/day imipenem + cilastatin and 25 mg/kg/day amikacin in the Pseudomonas group), one received antibiotic and bacteriophage, and one received no treatment. Animals receiving bacteriophage therapy were injected locally with 107 bacteriophages in a 0.1-mL suspension on three consecutive days. All animals were killed on the fifteenth day after initiation of treatment, and the tibia was excised. Results were assessed with use of microbiology, light microscopy, and electron microscopy. In the MRSA group, the antibiotic administration significantly decreased the number of colony-forming units per subject in quantitative cultures (control subgroup, 50,586; bacteriophage, 30,788; antibiotic, 17,165; antibiotic + bacteriophage, 5000; p = 0.004 for the comparison of the latter group with the control). Biofilm was absent only in the antibiotic + bacteriophage subgroup. In the Pseudomonas group, the number of colony-forming units per subject in quantitative cultures was significantly lower in each treatment subgroup compared with the control subgroup (control subgroup, 14,749; bacteriophage, 6484 [p = 0.016]; antibiotic, 2619 [p = 0.01]; antibiotic + bacteriophage, 1705 [p bacteriophage subgroup was also significantly lower than the values in the

  6. Modelling the relation between income and commuting distance

    DEFF Research Database (Denmark)

    Carra, Giulia; Mulalic, Ismir; Fosgerau, Mogens

    2016-01-01

    slowly as a power law with an exponent less than one that depends on the country considered. The classical theory for job search is based on the idea that workers evaluate the wage of potential jobs as they arrive sequentially through time, and extending this model with space, we obtain predictions...... that are strongly contradicted by our empirical findings. We propose an alternative model that is based on the idea that workers evaluate potential jobs based on a quality aspect and that workers search for jobs sequentially across space. We also assume that the density of potential jobs depends on the skills...

  7. Animal models for the study of hepatitis B virus infection

    Directory of Open Access Journals (Sweden)

    Wei-Na Guo

    2018-01-01

    Full Text Available Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus (HBV worldwide. Current antiviral therapies, including interferon and nucleot(side analogues, rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathogenesis of chronic hepatitis B and developing new therapeutic drugs or strategies. HBV can only infect humans and chimpanzees, with the use of chimpanzees in HBV research strongly restricted. Thus, most advances in HBV research have been gained using mouse models with HBV replication or infection or models with HBV-related hepadnaviral infection. This review summarizes the animal models currently available for the study of HBV infection.

  8. Limits on decaying dark energy density models from the CMB temperature-redshift relation

    International Nuclear Information System (INIS)

    Jetzer, Philippe; Tortora, Crescenzo

    2012-01-01

    We discuss the thermodynamic and dynamical properties of a variable dark energy model with density scaling as ρx ∝ (1 + z) m , z being the redshift. These models lead to the creation/disruption of matter and radiation, which affect the cosmic evolution of both matter and radiation components in the Universe. In particular, we have studied the temperature-redshift relation of radiation, which has been constrained using a recent collection of cosmic microwave background (CMB) temperature measurements up to z ∼ 3. We find that, within the uncertainties, the model is indistinguishable from a cosmological constant which does not exchange any particles with other components. Future observations, in particular measurements of CMB temperature at large redshift, will allow to give firmer bounds on the effective equation of state parameter w eff for such types of dark energy models.

  9. Hydra, a model system for environmental studies.

    Science.gov (United States)

    Quinn, Brian; Gagné, François; Blaise, Christian

    2012-01-01

    Hydra have been extensively used for studying the teratogenic and toxic potential of numerous toxins throughout the years and are more recently growing in popularity to assess the impacts of environmental pollutants. Hydra are an appropriate bioindicator species for use in environmental assessment owing to their easily measurable physical (morphology), biochemical (xenobiotic biotransformation; oxidative stress), behavioural (feeding) and reproductive (sexual and asexual) endpoints. Hydra also possess an unparalleled ability to regenerate, allowing the assessment of teratogenic compounds and the impact of contaminants on stem cells. Importantly, Hydra are ubiquitous throughout freshwater environments and relatively easy to culture making them appropriate for use in small scale bioassay systems. Hydra have been used to assess the environmental impacts of numerous environmental pollutants including metals, organic toxicants (including pharmaceuticals and endocrine disrupting compounds), nanomaterials and industrial and municipal effluents. They have been found to be among the most sensitive animals tested for metals and certain effluents, comparing favourably with more standardised toxicity tests. Despite their lack of use in formalised monitoring programmes, Hydra have been extensively used and are regarded as a model organism in aquatic toxicology.

  10. Relational Rurals: Some Thoughts on Relating Things and Theory in Rural Studies

    Science.gov (United States)

    Heley, Jesse; Jones, Laura

    2012-01-01

    This paper considers how shifts within the social sciences towards conceptualising spatiality in relational terms have unfolded in rural studies in particular ways over the past decade or so. A period in which networks, connections, flows and mobility have all established themselves as compelling conceptual frames for research, the rural has…

  11. Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models.

    Science.gov (United States)

    Martínez-Cerdeño, Verónica

    2017-04-01

    Dendrites and spines are the main neuronal structures receiving input from other neurons and glial cells. Dendritic and spine number, size, and morphology are some of the crucial factors determining how signals coming from individual synapses are integrated. Much remains to be understood about the characteristics of neuronal dendrites and dendritic spines in autism and related disorders. Although there have been many studies conducted using autism mouse models, few have been carried out using postmortem human tissue from patients. Available animal models of autism include those generated through genetic modifications and those non-genetic models of the disease. Here, we review how dendrite and spine morphology and number is affected in autism and related neurodevelopmental diseases, both in human, and genetic and non-genetic animal models of autism. Overall, data obtained from human and animal models point to a generalized reduction in the size and number, as well as an alteration of the morphology of dendrites; and an increase in spine densities with immature morphology, indicating a general spine immaturity state in autism. Additional human studies on dendrite and spine number and morphology in postmortem tissue are needed to understand the properties of these structures in the cerebral cortex of patients with autism. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 419-437, 2017. © 2016 Wiley Periodicals, Inc.

  12. Review of family relational stress and pediatric asthma: the value of biopsychosocial systemic models.

    Science.gov (United States)

    Wood, Beatrice L; Miller, Bruce D; Lehman, Heather K

    2015-06-01

    Asthma is the most common chronic disease in children. Despite dramatic advances in pharmacological treatments, asthma remains a leading public health problem, especially in socially disadvantaged minority populations. Some experts believe that this health gap is due to the failure to address the impact of stress on the disease. Asthma is a complex disease that is influenced by multilevel factors, but the nature of these factors and their interrelations are not well understood. This paper aims to integrate social, psychological, and biological literatures on relations between family/parental stress and pediatric asthma, and to illustrate the utility of multilevel systemic models for guiding treatment and stimulating future research. We used electronic database searches and conducted an integrated analysis of selected epidemiological, longitudinal, and empirical studies. Evidence is substantial for the effects of family/parental stress on asthma mediated by both disease management and psychobiological stress pathways. However, integrative models containing specific pathways are scarce. We present two multilevel models, with supporting data, as potential prototypes for other such models. We conclude that these multilevel systems models may be of substantial heuristic value in organizing investigations of, and clinical approaches to, the complex social-biological aspects of family stress in pediatric asthma. However, additional systemic models are needed, and the models presented herein could serve as prototypes for model development. © 2015 Family Process Institute.

  13. Model, Materialism, and Immanent Utopia in Relational Aesthetics

    DEFF Research Database (Denmark)

    Degn Johansson, Troels

    ) metaphor where social reality is staged and facilitated in order to document and present its development. At the same time however, the notion of model is difficult to dissociate from Bourriaud's materialism which draws on such different figures as the late Althusser, Lucretius, and Deleuze and which...

  14. Control mechanisms for a nonlinear model of international relations

    Energy Technology Data Exchange (ETDEWEB)

    Pentek, A.; Kadtke, J. [Univ. of California, San Diego, La Jolla, CA (United States). Inst. for Pure and Applied Physical Sciences; Lenhart, S. [Univ. of Tennessee, Knoxville, TN (United States). Mathematics Dept.; Protopopescu, V. [Oak Ridge National Lab., TN (United States). Computer Science and Mathematics Div.

    1997-07-15

    Some issues of control in complex dynamical systems are considered. The authors discuss two control mechanisms, namely: a short range, reactive control based on the chaos control idea and a long-term strategic control based on an optimal control algorithm. They apply these control ideas to simple examples in a discrete nonlinear model of a multi-nation arms race.

  15. On some asymptotic relations in the Boltzmann-Enskog model

    International Nuclear Information System (INIS)

    Sadovnikov, B.I.; Inozemtseva, N.G.

    1977-04-01

    The coefficients in the tsup(-3/2) asymptotics of the time autocorrelation functions are successively determined in the framework of the non-linear Boltzmann-Enskog model. The left and right eigenfunction systems are constructed for the Boltzmann-Enskog operator

  16. Reciprocal Relations between Work-Related Authenticity and Intrinsic Motivation, Work Ability and Depressivity: A Two-Wave Study.

    Science.gov (United States)

    Emmerich, Astrid I; Rigotti, Thomas

    2017-01-01

    This study investigates the role of context-specific authenticity at work for work-related outcomes (intrinsic motivation, work ability) and depressivity. Furthermore reciprocal relations between work-related authenticity and healthy psychological functioning are investigated. Longitudinal data from 1,243 employees from 63 subsidiaries of a non-profit organization in the social sector were analyzed using multilevel structural equation modeling. Work-related authenticity at T1 predicted work ability and depressivity, but not intrinsic motivation at T2, about 6 months later. Work-related authenticity at T2 was predicted by intrinsic motivation and depressivity, but not by work ability at T1. We conclude that work-related authenticity and healthy psychological functioning are positively reinforcing each other. Thus, enabling employees to be authentic supposedly increases their well-being and is a pivotal opportunity for organizations to foster health and performance-related indicators like work ability and prevent negative health indicators like depressivity. At the same time, authenticity of employees can be fostered through workplace health promotion.

  17. Applications of relative motion models using curvilinear coordinate frames

    Science.gov (United States)

    Perez, Alex C.

    An angles-only initial relative orbit determination aglorithm is derived using three line-of-sight observations or six angle measurements. This is accomplished by taking a Singular Value Decomposition of a 6x6 matrix to get a right singular vector approximately in the direction of the initial line-of-sight vector. Then an approximate initial relative orbit determination algorithm is derived that computes the range from the chief to the deputy vehicle. This involves the approximate solution of 6 poylnomial equations in 6 unknowns. An iterative improvement is also derived that provides the exact solution, to numerical precision, of the 6 polynomial equations in 6 unknowns. The initial relative orbit algorithm is also expanded for more than three line-of-sight observations with an iterative improvement algorithm for more than three line-of-sight observations. The algorithm is tested for a range of relative motion cases in low earth orbit and geosynchronous orbit, with and without the inclusion of J2 perturbations and with camera measurement errors.

  18. Health-Related Fitness Models in Physical Education

    Science.gov (United States)

    Houston, Jennifer; Kulinna, Pamela

    2014-01-01

    Physical education has been an integral part of the school curriculum for more than a century. Although the focus has changed over time, the major objective has remained relatively constant: to provide students with the knowledge, skills, abilities, behaviors, and confidence to be physically active throughout their lifetime. As more physical…

  19. Action Relations. Basic Design Concepts for Behaviour Modelling and Refinement.

    NARCIS (Netherlands)

    Quartel, Dick

    This thesis presents basic design concepts, design methods and a basic design language for distributed system behaviours. This language is based on two basic concepts: the action concept and the causality relation concept. Our methods focus on behaviour refinement, which consists of replacing an

  20. A Model-Based Exploration and Policy Analysis Related to Prostitution and Human Trafficking

    OpenAIRE

    András Kővári; Erik Pruyt

    2014-01-01

    This paper presents a model-based exploration and policy analysis related to prostitution and prostitution-related human trafficking. After a brief introduction to prostitution and prostitution-related human trafficking, the paper zooms in on the Dutch situation. A System Dynamics simulation model related to the Dutch situation developed to explore and provide policy insights is subsequently presented. Using the simulation model, policies are first of all tested, and preliminary conclusions a...

  1. Testing a social ecological model for relations between political violence and child adjustment in Northern Ireland.

    Science.gov (United States)

    Cummings, E Mark; Merrilees, Christine E; Schermerhorn, Alice C; Goeke-Morey, Marcie C; Shirlow, Peter; Cairns, Ed

    2010-05-01

    Relations between political violence and child adjustment are matters of international concern. Past research demonstrates the significance of community, family, and child psychological processes in child adjustment, supporting study of interrelations between multiple social ecological factors and child adjustment in contexts of political violence. Testing a social ecological model, 300 mothers and their children (M = 12.28 years, SD = 1.77) from Catholic and Protestant working class neighborhoods in Belfast, Northern Ireland, completed measures of community discord, family relations, and children's regulatory processes (i.e., emotional security) and outcomes. Historical political violence in neighborhoods based on objective records (i.e., politically motivated deaths) were related to family members' reports of current sectarian antisocial behavior and nonsectarian antisocial behavior. Interparental conflict and parental monitoring and children's emotional security about both the community and family contributed to explanatory pathways for relations between sectarian antisocial behavior in communities and children's adjustment problems. The discussion evaluates support for social ecological models for relations between political violence and child adjustment and its implications for understanding relations in other parts of the world.

  2. The neuromechanism underlying verbal analogical reasoning of metaphorical relations: an event-related potentials study.

    Science.gov (United States)

    Zhao, Ming; Meng, Huishan; Xu, Zhiyuan; Du, Fenglei; Liu, Tao; Li, Yongxin; Chen, Feiyan

    2011-11-24

    Using event-related potentials (ERPs), this study investigated the neuromechanism underlying verbal analogical reasoning of two different metaphorical relations: attributive metaphor and relational metaphor. The analogical reasoning of attributive metaphor (AM-AR) involves a superficial similarity between analogues, while the analogical reasoning of relational metaphor (RM-AR) requires a structural similarity. Subjects were asked to judge whether one word pair was semantically analogous to another word pair. Results showed that the schema induction stage elicited a greater N400 component at the right anterior scalp for the AM-AR and RM-AR tasks, possibly attributable to semantic processing of metaphorical word pairs. The N400 was then followed by a widely distributed P300 and a late negative component (LNC1) at the left anterior scalp. The P300 was possibly related to the formation of a relational category, while the LNC1 was possibly related to the maintenance of a reasoning cue in working memory. The analogy mapping stage elicited broadly distributed N400 and LNC2, which might indicate the presence of semantic retrieval and analogical transfer. In the answer production stage, all conditions elicited the P2 component due to early stimulus encoding. The largest P2 amplitude was in the RM-AR task. The RM-AR elicited a larger LPC than did the AM-AR, even though the baseline correction was taken as a control for the differential P2 effect. The LPC effect might suggest that relational metaphors involved more integration processing than attributive metaphors. Copyright © 2011 Elsevier B.V. All rights reserved.

  3. Age-related spontaneous lumbar intervertebral disc degeneration in a mouse model.

    Science.gov (United States)

    Ohnishi, Takashi; Sudo, Hideki; Tsujimoto, Takeru; Iwasaki, Norimasa

    2018-01-01

    The pathogenesis of intervertebral disc degeneration is unclear, but it is a major cause of several spinal diseases. Animal models have historically provided an appropriate benchmark for understanding the human spine. However, there is little information about when intervertebral disc degeneration begins in the mouse or regarding the relationship between magnetic resonance imaging and histological findings. The aim for this study was to obtain information about age-related spontaneous intervertebral disc degeneration in the mouse lumbar spine using magnetic resonance imaging and a histological score regarding when the intervertebral disc degeneration started and how rapidly it progressed, as well as how our histological score detected the degeneration. The magnetic resonance imaging index yielded a moderate correlation with our Age-related model score. The Pfirrmann grade and magnetic resonance imaging index had moderate correlations with age. However, our Age-related model score had a high correlation with age. Intervertebral disc level was not a significant variable for the severity of disc degeneration. Both Pfirrmann grade and the Age-related model score were higher in the ≥14-month-old group than in the 6-month-old group. The present results indicated that mild but significant intervertebral disc degeneration occurred in 14-month-old mice, and the degree of degeneration progressed slowly, reaching a moderate to severe condition for 22-month-old mice. At least a 14-month follow-up is mandatory for evaluating spontaneous age-related mouse intervertebral disc degeneration. The histological classification score can precisely detect the gradual progression of age-related spontaneous intervertebral disc degeneration in the mouse lumbar spine, and is appropriate for evaluating it. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:224-232, 2018. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  4. Winter precipitation characteristics in western US related to atmospheric river landfalls: observations and model evaluations

    Science.gov (United States)

    Kim, J.; Guan, B.; Waliser, D. E.; Ferraro, R. D.; Case, J. L.; Iguchi, T.; Kemp, E.; Putman, W.; Wang, W.; Wu, D.; Tian, B.

    2018-01-01

    Winter precipitation (PR) characteristics in western United States (WUS) related to atmospheric river (AR) landfalls are examined using the observation-based PRISM data. The observed AR-related precipitation characteristics are in turn used to evaluate model precipitation data from the NASA MERRA2 reanalysis and from seven dynamical downscaling simulations driven by the MERRA2. Multiple metrics including mean bias, Taylor diagram, and two skill scores are used to measure model performance for three climatological sub-regions in WUS, Pacific Northwest (PNW), Pacific Southwest (PSW) and Great Basin (GB). All model data well represent the winter-mean PR with spatial pattern correlations of 0.8 or higher with PRISM for the three sub-regions. Higher spatial resolutions and/or the use of spectral nudging generally yield higher skill scores in simulating the geographical distribution of PR for the entire winter. The PRISM data shows that the AR-related fraction of winter PR and associated daily PR PDFs in each region vary strongly for landfall locations; AR landfalls in the northern WUS coast (NC) affect mostly PNW while those in the southern WUS coast (SC) affect both PSW and GB. NC (SC) landfalls increase the frequency of heavy PR in PNW (PSW and GB) but reduce it in PSW (PNW). All model data reasonably represent these observed variations in the AR-related winter PR fractions and the daily PR PDFs according to AR landfall locations. However, unlike for the entire winter period, no systematic effects of resolution and/or spectral nudging are identified in these AR-related PR characteristics. Dynamical downscaling in this study generally yield positive added values to the MERRA2 PR in the AR-related PR fraction for most sub-regions and landfall locations, most noticeably for PSW by NU-WRF. The downscaling also generate positive added value in p95 for PNW, but negative values for PSW and GB due to overestimation of heavy precipitation events.

  5. Cancer-related fatigue in breast cancer patients after surgery: a multicomponent model using partial least squares-path modeling.

    Science.gov (United States)

    Bortolon, Catherine; Krikorian, Alicia; Carayol, Marion; Brouillet, Denis; Romieu, Gilles; Ninot, Gregory

    2014-04-01

    The aim of this study is to examine factors contributing to cancer-related fatigue (CRF) in breast cancer patients who have undergone surgery. Sixty women (mean age: 50.0) completed self-rated questionnaires assessing components of CRF, muscular and cognitive functions. Also, physiological and subjective data were gathered. Data were analyzed using partial least squares variance-based structural equation modeling in order to examine factors contributing to CRF after breast surgery. The tested model was robust in terms of its measurement quality (reliability and validity). According to the structural model results, emotional distress (β = 0.59; p accounting for 61% of the explained variance. Also, emotional distress (β = 0.41; p accounted for 41% of the explained variance. However, the relationship between low physical function and CRF was weak and nonsignificant (β = 0.01; p > 0.05). Emotional distress, altered vigilance capacity, and pain are associated with CRF in postsurgical breast cancer. In addition, emotional distress and pain are related to diminished physical function, which, in turn, has no significant impact on CRF. The current model should be examined in subsequent phases of the treatment (chemotherapy and/or radiotherapy) when side effects are more pronounced and may lead to increased intensity of CRF and low physical function. Copyright © 2013 John Wiley & Sons, Ltd.

  6. Using computational models to relate structural and functional brain connectivity

    Czech Academy of Sciences Publication Activity Database

    Hlinka, Jaroslav; Coombes, S.

    2012-01-01

    Roč. 36, č. 2 (2012), s. 2137-2145 ISSN 0953-816X R&D Projects: GA MŠk 7E08027 EU Projects: European Commission(XE) 200728 - BRAINSYNC Institutional research plan: CEZ:AV0Z10300504 Keywords : brain disease * computational modelling * functional connectivity * graph theory * structural connectivity Subject RIV: FH - Neurology Impact factor: 3.753, year: 2012

  7. A Study of Some Rostrofacial Indices Related to Regional ...

    African Journals Online (AJOL)

    With increasing use of the porcine species as experimental models for improvement of human dental implants, this work will further aid the knowledge of the regional anaesthesia of this species in dental implant studies and could be of value in the surgical intervention of priced animals. Keywords: Rostrofacial, Regional ...

  8. A Study of Some Rostrofacial Indices Related to Regional ...

    African Journals Online (AJOL)

    Chigo Okwuosa

    porcine species as experimental models for improvement of human dental implants, this work will further aid the knowledge of the regional anaesthesia of this species in dental implant studies and could be of value in the surgical intervention of priced animals. Keywords: Rostrofacial, Regional anaesthesia, Nerve block, ...

  9. Strengths only or strengths and relative weaknesses? A preliminary study.

    Science.gov (United States)

    Rust, Teri; Diessner, Rhett; Reade, Lindsay

    2009-10-01

    Does working on developing character strengths and relative character weaknesses cause lower life satisfaction than working on developing character strengths only? The present study provides a preliminary answer. After 76 college students completed the Values in Action Inventory of Strengths (C. Peterson & M. E. P. Seligman, 2004), the authors randomly assigned them to work on 2 character strengths or on 1 character strength and 1 relative weakness. Combined, these groups showed significant gains on the Satisfaction With Life Scale (E. Diener, R. A. Emmons, R. J. Larsen, & S. Griffin, 1985), compared with a 32-student no-treatment group. However, there was no significant difference in gain scores between the 2-strengths group and the 1-character-strength-and-1-relative-character-weakness group. The authors discuss how focusing on relative character weaknesses (along with strengths) does not diminish-and may assist in increasing-life satisfaction.

  10. Bayesian graphical models for genomewide association studies.

    Science.gov (United States)

    Verzilli, Claudio J; Stallard, Nigel; Whittaker, John C

    2006-07-01

    As the extent of human genetic variation becomes more fully characterized, the research community is faced with the challenging task of using this information to dissect the heritable components of complex traits. Genomewide association studies offer great promise in this respect, but their analysis poses formidable difficulties. In this article, we describe a computationally efficient approach to mining genotype-phenotype associations that scales to the size of the data sets currently being collected in such studies. We use discrete graphical models as a data-mining tool, searching for single- or multilocus patterns of association around a causative site. The approach is fully Bayesian, allowing us to incorporate prior knowledge on the spatial dependencies around each marker due to linkage disequilibrium, which reduces considerably the number of possible graphical structures. A Markov chain-Monte Carlo scheme is developed that yields samples from the posterior distribution of graphs conditional on the data from which probabilistic statements about the strength of any genotype-phenotype association can be made. Using data simulated under scenarios that vary in marker density, genotype relative risk of a causative allele, and mode of inheritance, we show that the proposed approach has better localization properties and leads to lower false-positive rates than do single-locus analyses. Finally, we present an application of our method to a quasi-synthetic data set in which data from the CYP2D6 region are embedded within simulated data on 100K single-nucleotide polymorphisms. Analysis is quick (<5 min), and we are able to localize the causative site to a very short interval.

  11. Structural studies of human glioma pathogenesis-related protein 1

    Energy Technology Data Exchange (ETDEWEB)

    Asojo, Oluwatoyin A., E-mail: oasojo@unmc.edu [College of Medicine, Nebraska Medical Center, Omaha, NE 68198-6495 (United States); Koski, Raymond A.; Bonafé, Nathalie [L2 Diagnostics LLC, 300 George Street, New Haven, CT 06511 (United States); College of Medicine, Nebraska Medical Center, Omaha, NE 68198-6495 (United States)

    2011-10-01

    Structural analysis of a truncated soluble domain of human glioma pathogenesis-related protein 1, a membrane protein implicated in the proliferation of aggressive brain cancer, is presented. Human glioma pathogenesis-related protein 1 (GLIPR1) is a membrane protein that is highly upregulated in brain cancers but is barely detectable in normal brain tissue. GLIPR1 is composed of a signal peptide that directs its secretion, a conserved cysteine-rich CAP (cysteine-rich secretory proteins, antigen 5 and pathogenesis-related 1 proteins) domain and a transmembrane domain. GLIPR1 is currently being investigated as a candidate for prostate cancer gene therapy and for glioblastoma targeted therapy. Crystal structures of a truncated soluble domain of the human GLIPR1 protein (sGLIPR1) solved by molecular replacement using a truncated polyalanine search model of the CAP domain of stecrisp, a snake-venom cysteine-rich secretory protein (CRISP), are presented. The correct molecular-replacement solution could only be obtained by removing all loops from the search model. The native structure was refined to 1.85 Å resolution and that of a Zn{sup 2+} complex was refined to 2.2 Å resolution. The latter structure revealed that the putative binding cavity coordinates Zn{sup 2+} similarly to snake-venom CRISPs, which are involved in Zn{sup 2+}-dependent mechanisms of inflammatory modulation. Both sGLIPR1 structures have extensive flexible loop/turn regions and unique charge distributions that were not observed in any of the previously reported CAP protein structures. A model is also proposed for the structure of full-length membrane-bound GLIPR1.

  12. Prognostic immune-related gene models for breast cancer: a pooled analysis

    Directory of Open Access Journals (Sweden)

    Zhao J

    2017-09-01

    Full Text Available Jianli Zhao,1,2,* Ying Wang,1,2,* Zengding Lao,3,* Siting Liang,3 Jingyi Hou,4 Yunfang Yu,1,2 Herui Yao,1,2 Na You,3 Kai Chen1,2 1Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; 2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; 3School of Mathematics, Sun Yat-Sen University, Guangzhou, China; 4Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China *These authors contributed equally to this work Abstract: Breast cancer, the most common cancer among women, is a clinically and biologically heterogeneous disease. Numerous prognostic tools have been proposed, including gene signatures. Unlike proliferation-related prognostic gene signatures, many immune-related gene signatures have emerged as principal biology-driven predictors of breast cancer. Diverse statistical methods and data sets were used for building these immune-related prognostic models, making it difficult to compare or use them in clinically meaningful ways. This study evaluated successfully published immune-related prognostic gene signatures through systematic validations of publicly available data sets. Eight prognostic models that were built upon immune-related gene signatures were evaluated. The performances of these models were compared and ranked in ten publicly available data sets, comprising a total of 2,449 breast cancer cases. Predictive accuracies were measured as concordance indices (C-indices. All tests of statistical significance were two-sided. Immune-related gene models performed better in estrogen receptor-negative (ER- and lymph node-positive (LN+ breast cancer subtypes. The three top-ranked ER- breast cancer models achieved overall C-indices of 0.62–0.63. Two models predicted better than chance for ER+ breast cancer, with C-indices of 0.53 and 0.59, respectively. For

  13. A Comparison of a Relational and Nested-Relational IDEF0 Data Model

    Science.gov (United States)

    1990-03-01

    model represents the actual graphical constructs, e.g., boxes, line segments, etc., used to represent the particular IDEF0 anal - As with the essential...screen location represented in (x,y). select se.a, sa.ys. sexo , seye from segment so where se.sheet-id in select s.sheet-id from activity a, sheet s

  14. Action Relations. Basic Design Concepts for Behaviour Modelling and Refinement.

    OpenAIRE

    Quartel, Dick

    1998-01-01

    This thesis presents basic design concepts, design methods and a basic design language for distributed system behaviours. This language is based on two basic concepts: the action concept and the causality relation concept. Our methods focus on behaviour refinement, which consists of replacing an abstract behaviour by a more concrete behaviour, such that the concrete behaviour conforms to the abstract behaviour. An important idea underlying this thesis is that an effective design methodology s...

  15. The psychological influences on participation in Wheelchair Rugby: a social relational model of disability

    Directory of Open Access Journals (Sweden)

    Damian Haslett

    2017-06-01

    Full Text Available Sport and exercise psychology research in disability sport seldom engages with social models of disability. As a result, the socio-historical landscape of disability is underrepresented in sport psychology research. The aim of this study is to interpret influences on participation in disability sport through the conceptual lens of the social relational model (SRM of disability (Thomas, 1999, 2004, 2007. Ten Irish adult male athletes with physical disabilities participated in semi-structured interviews exploring the barriers and facilitators that influence participation in Wheelchair Rugby. Deductive thematic analysis produced four themes influenced by the social relational model: impairment effects; societal attitudes and discourse; opportunities and access; and psychological well-being. Links were made to the experience of embodied impairment, classification, oppression, inequality, media, independence, and self-efficacy. The analysis illustrates how cultural constructions of disability are inextricably linked to individual influences on participation in Wheelchair Rugby. The results indicate that in disability sport participation, the experience of social oppression, inequality and cultural stereotypes of disability can be synonymous with the personal experience of physical impairment. The implication of this research is that there is a value in sport and exercise psychology practitioners utilising the social relational model as a tool to conceptualise the lived experience of physical disability.

  16. Ethical issues related to biomonitoring studies on children

    DEFF Research Database (Denmark)

    Pedersen, Marie; Merlo, Domenico Franco; Knudsen, Lisbeth E.

    2007-01-01

    -off and the recruitments. In the initial phase of planning a biomonitoring study consideration of communication of results including risk and means of risk prevention should be made. Ethical considerations regarding the study protocol should take into account (a) justification of biological sampling related...... to the expected outcome(s), (b) causing no harm to the child, (c) appropriate and comprehensive communication to the participating child as well as the parents and tutors, (d) informed assent or consent including the right to withdraw (e) communication of results to research participants and (f) access to own...... biomonitoring studies should be communicated and study persons notified for further use of data and samples....

  17. LEARNING MODEL IN SCHOOL OF VOCATIONAL STUDIES

    OpenAIRE

    Bal, Pervin; Yıldırım, Osman

    2008-01-01

    In this research, it is aimed to determine which individual and environmental characteristics affecting training. Instead of both types of evaluation models, to be proactive, the evaluation of training mentioned in this research is focused on how training affects individuals. To this end, in this thesis the factors affecting to the training effectiveness were examined in regard of trainee perspectives. According to the research results, it is revealed that mostly related to the training effec...

  18. How valuable are model organisms for transposable element studies?

    Science.gov (United States)

    Kidwell, M G; Evgen'ev, M B

    1999-01-01

    Model organisms have proved to be highly informative for many types of genetic studies involving 'conventional' genes. The results have often been successfully generalized to other closely related organisms and also, perhaps surprisingly frequently, to more distantly related organisms. Because of the wealth of previous knowledge and their availability and convenience, model organisms were often the species of choice for many of the earlier studies of transposable elements. The question arises whether the results of genetic studies of transposable elements in model organisms can be extrapolated in the same ways as those of conventional genes? A number of observations suggest that special care needs to be taken in generalizing the results from model organisms to other species. A hallmark of many transposable elements is their ability to amplify rapidly in species genomes. Rapid spread of a newly invaded element throughout a species range has also been demonstrated. The types and genomic copy numbers of transposable elements have been shown to differ greatly between some closely related species. Horizontal transfer of transposable elements appears to be more frequent than for nonmobile genes. Furthermore, the population structure of some model organisms has been subject to drastic recent changes that may have some bearing on their transposable element genomic complements. In order to initiate discussion of this question, several case studies of transposable elements in well-studied Drosophila species are presented.

  19. Consumer Health-Related Activities on Social Media: Exploratory Study.

    Science.gov (United States)

    Benetoli, Arcelio; Chen, Timothy F; Aslani, Parisa

    2017-10-13

    Although a number of studies have investigated how consumers use social media for health-related purposes, there is a paucity of studies in the Australian context. This study aimed to explore how Australian consumers used social media for health-related purposes, specifically how they identified social media platforms, which were used, and which health-related activities commonly took place. A total of 5 focus groups (n=36 participants), each lasting 60 to 90 minutes, were conducted in the Sydney metropolitan area. The group discussions were audiorecorded and transcribed verbatim. The transcripts were coded line-by-line and thematically analyzed. Participants used general search engines to locate health-related social media platforms. They accessed a wide range of social media on a daily basis, using several electronic devices (in particular, mobile phones). Although privacy was a concern, it did not prevent consumers from fully engaging in social media for health-related purposes. Blogs were used to learn from other people's experiences with the same condition. Facebook allowed consumers to follow health-related pages and to participate in disease-specific group discussions. Wikipedia was used for factual information about diseases and treatments. YouTube was accessed to learn about medical procedures such as surgery. No participant reported editing or contributing to Wikipedia or posting YouTube videos related to health topics. Twitter was rarely used for health-related purposes. Social media allowed consumers to obtain and provide disease and treatment-related information and social and emotional support for those living with the same condition. Most considered their participation as observational, but some also contributed (eg, responded to people's questions). Participants used a wide range of social media for health-related purposes. Medical information exchange (eg, disease and treatment) and social and emotional support were the cornerstones of their online

  20. A climatological study of the relations among solar activity, galactic ...

    Indian Academy of Sciences (India)

    Though correlation study between precipitation and other parameters do not hint any linear relation, still the Fourier and wavelet analyses give an idea of common periodicities. The 9–11 year periodicity of sunspot numbers calculated by Fourier transform is also confirmed by wavelet transform in annual scale. Similarly ...

  1. Gambling-Related Distortions and Problem Gambling in Adolescents: A Model to Explain Mechanisms and Develop Interventions

    OpenAIRE

    Donati, Maria Anna; Chiesi, Francesca; Iozzi, Adriana; Manfredi, Antonella; Fagni, Fabrizio; Primi, Caterina

    2018-01-01

    Although a number of gambling preventive initiatives have been realized with adolescents, many of them have been developed in absence of a clear and explicitly described theoretical model. The present work was aimed to analyze the adequacy of a model to explain gambling behavior referring to gambling-related cognitive distortions (Study 1), and to verify the effectiveness of a preventive intervention developed on the basis of this model (Study 2). Following dual-process theories on cognitive ...

  2. Woodworking injuries: a comparative study of work-related and hobby-related accidents.

    Science.gov (United States)

    Loisel, F; Bonin, S; Jeunet, L; Pauchot, J; Tropet, Y; Obert, L

    2014-10-01

    The primary objective of this study was to describe the injury characteristics and demographics of patients injured during woodworking activities, upon their arrival to the emergency department in a regional of France where this industry is prevalent. The secondary objective was to compare patient and injury characteristics for work-related and hobby-related accidents. A cohort of 87 patients who had suffered a woodworking accident over a two-year period was evaluated; 79 were available for follow-up. The context and circumstances of the accident, nature and location of the injuries and patient demographics were recorded. Hobby-related accidents accounted for two-thirds of the accidents (51/79). Most of the injured workers were either loggers (35%) or carpenters (46%). The hand was injured in 53 cases (67%). Work-related accidents resulted in significantly more serious consequences in terms of hospital stay, work stoppage, resumption of work or retraining than hobby-related accidents. For the workplace accidents, 86% occurred on new machines; more than 25% of the machines involved in accidents at home were over 15 years. Sixty-eight per cent of workers were wearing their safety gear, while only 31% of those injured during recreational woodworking wore the appropriate gear. Several elements of prevention should be improved: information about the need to maintain the equipment, protect the worker with suitable clothing, and learn which maneuvers are considered hazardous. Safety gear should be regularly inspected in the workplace. Copyright © 2014. Published by Elsevier SAS.

  3. Analytical model of stemwood growth in relation to nitrogen supply.

    Science.gov (United States)

    Dewar, Roderick C.; McMurtrie, Ross E.

    1996-01-01

    We derived a simplified version of a previously published process-based model of forest productivity and used it to gain information about the dependence of stemwood growth on nitrogen supply. The simplifications we made led to the following general expression for stemwood carbon (c(w)) as a function of stand age (t), which shows explicitly the main factors involved: c(w)(t) = eta(w)G*/ micro (w)(1 - lambdae(- micro (w)t) - micro (w)e(-lambdat)/lambda - micro (w)), where eta(w) is the fraction of total carbon production (G) allocated to stemwood, G* is the equilibrium value of G at canopy closure, lambda describes the rate at which G approaches G*, and micro (w) is the combined specific rate of stemwood maintenance respiration and senescence. According to this equation, which describes a sigmoidal growth curve, c(w) is zero initially and asymptotically approaches eta(w)G*/ micro (w) with the rate of approach dependent on lambda and micro (w). We used this result to derive corresponding expressions for the maximum mean annual stem-wood volume increment (Y) and optimal rotation length (T). By calculating the quantities G* and lambda (which characterize the variation of carbon production with stand age) as functions of the supply rate of plant-available nitrogen (U(o)), we estimated the responses of Y and T to changes in U(o). For a plausible set of parameter values, as U(o) increased from 50 to 150 kg N ha(-1) year(-1), Y increased approximately linearly from 8 to 25 m(3) ha(-1) year(-1) (mainly as a result of increasing G*), whereas T decreased from 21 to 18 years (due to increasing lambda). The sensitivity of Y and T to other model parameters was also investigated. The analytical model provides a useful basis for examining the effects of changes in climate and nutrient supply on sustainable forest productivity, and may also help in interpreting the behavior of more complex process-based models of forest growth.

  4. Comparative Study of Bancruptcy Prediction Models

    Directory of Open Access Journals (Sweden)

    Isye Arieshanti

    2013-09-01

    Full Text Available Early indication of bancruptcy is important for a company. If companies aware of  potency of their bancruptcy, they can take a preventive action to anticipate the bancruptcy. In order to detect the potency of a bancruptcy, a company can utilize a a model of bancruptcy prediction. The prediction model can be built using a machine learning methods. However, the choice of machine learning methods should be performed carefully. Because the suitability of a model depends on the problem specifically. Therefore, in this paper we perform a comparative study of several machine leaning methods for bancruptcy prediction. According to the comparative study, the performance of several models that based on machine learning methods (k-NN, fuzzy k-NN, SVM, Bagging Nearest Neighbour SVM, Multilayer Perceptron(MLP, Hybrid of MLP + Multiple Linear Regression, it can be showed that fuzzy k-NN method achieve the best performance with accuracy 77.5%

  5. Towards a Definition of Role-related Concepts for Business Modeling

    NARCIS (Netherlands)

    Meertens, Lucas Onno; Iacob, Maria Eugenia; Nieuwenhuis, Lambertus Johannes Maria

    2010-01-01

    Abstract—While several role-related concepts play an important role in business modeling, their definitions, relations, and use differ greatly between languages, papers, and reports. Due to this, the knowledge captured by models is not transferred correctly, and models are incomparable. In this

  6. Unsupervised knowledge structuring Application of Infinite Relational Models to the FCA visualization

    DEFF Research Database (Denmark)

    Glückstad, Fumiko Kano; Herlau, Tue; Schmidt, Mikkel Nørgaard

    2013-01-01

    This work presents a conceptual framework for learning an ontological structure of domain knowledge, which combines Jaccard similarity coefficient with the Infinite Relational Model (IRM) by (Kemp et al. 2006) and its extended model, i.e. the normal-Infinite Relational Model (n-IRM) by (Herlau et...

  7. [The epidemiological study of work-related musculoskeletal disorders and related factors among automobile assembly workers].

    Science.gov (United States)

    Wang, Zhong-Xu; Qin, Ru-Li; Li, Yu-Zhen; Zhang, Xue-Yan; Jia, Ning; Zhang, Qiu-Ling; Li, Gang; Zhao, Jie; Li, Huan-Huan; Jiang, Hai-Qiang

    2011-08-01

    To investigate the work-related musculoskeletal disorders among automobile assembly workers, to discusses the related risk factors and their relationship. The selected 1508 automobile assembly workers from a north car manufacturing company were regarded as the study object. The hazard zone jobs checklist, Nordic musculoskeletal symptom questionnaire (NMQ) and pain questionnaire were used to perform the epidemiological cross-sectional and retrospective survey and study for the General status, awkward ergonomics factors and related influencing factors, and musculoskeletal disorders of workers. The predominant body sites of occurring WMSDs among automobile assembly workers were mainly low back, wrist, neck and shoulders, the predominant workshop section of occurring WMSDs were mostly concentrated in engine compartment, interior ornament, door cover, chassis and debugging section. The predominant body site of WMSDs among engine compartment and chassis section workers was low back, interior ornament workers were low back and wrist, door cover workers was wrist, chassis workers was low back, debugging workers were neck and low back. Neck musculoskeletal disorders had the trend with the increase of a body height; Smoking may increase the occurrence of musculoskeletal disorders. The WMSDs appears to be a serious ergonomic proble assem among automobile assembly workers, predominant occurring site of WMSDs is with different workshop section, its characteristics is quite obvious, probably related to its existing awkward work position or activities. The worker height and smoking habits may be important factors which affect musculoskeletal disorders happen.

  8. Atopic Dermatitis Studies through In Vitro Models

    Directory of Open Access Journals (Sweden)

    Evelyne De Vuyst

    2017-07-01

    Full Text Available Atopic dermatitis (AD is a complex inflammatory skin condition that is not fully understood. Epidermal barrier defects and Th2 immune response dysregulations are thought to play crucial roles in the pathogenesis of the disease. A vicious circle takes place between these alterations, and it can further be complicated by additional genetic and environmental factors. Studies investigating in more depth the etiology of the disease are thus needed in order to develop functional treatments. In recent years, there have been significant advances regarding in vitro models reproducing important features of AD. However, since a lot of models have been developed, finding the appropriate experimental setting can be difficult. Therefore, herein, we review the different types of in vitro models mimicking features of AD. The simplest models are two-dimensional culture systems composed of immune cells or keratinocytes, whereas three-dimensional skin or epidermal equivalents reconstitute more complex stratified tissues exhibiting barrier properties. In those models, hallmarks of AD are obtained, either by challenging tissues with interleukin cocktails overexpressed in AD epidermis or by silencing expression of pivotal genes encoding epidermal barrier proteins. Tissue equivalents cocultured with lymphocytes or containing AD patient cells are also described. Furthermore, each model is placed in its study context with a brief summary of the main results obtained. In conclusion, the described in vitro models are useful tools to better understand AD pathogenesis, but also to screen new compounds in the field of AD, which probably will open the way to new preventive or therapeutic strategies.

  9. Modeling and Study of the Cerenkov Effect

    CERN Document Server

    Angelov, I; Makovicka, L; Mishev, A; Stamenov, J N

    2003-01-01

    The studies realized in INRNE (Institute for Nuclear Research and Nuclear Energy) particulary in cosmic rays detection and construction of Muonic Cerenkov Telescope in University of Blagoevgrad [1] shows the need to develop a theoretical model based on observed phenomenon and to refine it for the detection system optimisation. The effect was introduced in EGS4 code system. The first simulations were consecrated to different geometry of water tank in total reflection. The model was compared with experimental data realised with gamma source using the telescope. A simple atmospheric model is introduced in EGS4. The comparison between CORSIKA and EGS4 codes was realised.

  10. Modeling Spatial Data within Object Relational-Databases

    Directory of Open Access Journals (Sweden)

    Iuliana BOTHA

    2011-03-01

    Full Text Available Spatial data can refer to elements that help place a certain object in a certain area. These elements are latitude, longitude, points, geometric figures represented by points, etc. However, when translating these elements into data that can be stored in a computer, it all comes down to numbers. The interesting part that requires attention is how to memorize them in order to obtain fast and various spatial queries. This part is where the DBMS (Data Base Management System that contains the database acts in. In this paper, we analyzed and compared two object-relational DBMS that work with spatial data: Oracle and PostgreSQL.

  11. Content-Related Interactions in Self-initiated Study Groups

    Science.gov (United States)

    Christian, Karen; Talanquer, Vicente

    2012-09-01

    The central goal of the present exploratory study was to investigate the nature of the content-related interactions in study groups independently organized by college organic chemistry students. We were particularly interested in the identification of the different factors that affected the emergence of opportunities for students to co-construct understanding and engage in higher levels of cognitive processing. Our results are based on the analysis of in situ observations of 34 self-initiated study sessions involving over a 100 students in three academic semesters. The investigation revealed three major types of social regulation processes, teaching, tutoring, and co-construction in the observed study sessions. However, the extent to which students engaged in each of them varied widely from one session to another. This variability was mostly determined by the specific composition of the study groups and the nature of the study tasks in which they were engaged. Decisions about how to organize the study session, the relative content knowledge and conceptual understanding expressed by the participants, as well as the cognitive level of the problems that guided group work had a strong impact on the nature of student interactions. Nevertheless, group talk in the observed study groups was mostly focused on low-level cognitive processes. The results of our work provide insights on how to better support students' productive engagement in study groups.

  12. Differential Equations Models to Study Quorum Sensing.

    Science.gov (United States)

    Pérez-Velázquez, Judith; Hense, Burkhard A

    2018-01-01

    Mathematical models to study quorum sensing (QS) have become an important tool to explore all aspects of this type of bacterial communication. A wide spectrum of mathematical tools and methods such as dynamical systems, stochastics, and spatial models can be employed. In this chapter, we focus on giving an overview of models consisting of differential equations (DE), which can be used to describe changing quantities, for example, the dynamics of one or more signaling molecule in time and space, often in conjunction with bacterial growth dynamics. The chapter is divided into two sections: ordinary differential equations (ODE) and partial differential equations (PDE) models of QS. Rates of change are represented mathematically by derivatives, i.e., in terms of DE. ODE models allow describing changes in one independent variable, for example, time. PDE models can be used to follow changes in more than one independent variable, for example, time and space. Both types of models often consist of systems (i.e., more than one equation) of equations, such as equations for bacterial growth and autoinducer concentration dynamics. Almost from the onset, mathematical modeling of QS using differential equations has been an interdisciplinary endeavor and many of the works we revised here will be placed into their biological context.

  13. Outcome study of brief relational-cultural therapy in a women's mental health center.

    Science.gov (United States)

    Oakley, M Anne; Addison, Shirley C; Piran, Niva; Johnston, Gary J; Damianakis, Mary; Curry, Joyce; Dunbar, Christine; Weigeldt, Almuth

    2013-01-01

    The current study is the first to evaluate the effectiveness of a brief relational-cultural model of therapy in a community-based mental health center for women. The study was distinctive in its use of a hybrid model that employed elements of randomized control and naturalistic design. Results showed that the entire treatment group of 91 women improved significantly on all eight outcome measures. Therapeutic gains were maintained at 3- and 6-month follow-ups. The results lend support to the importance of including relational-cultural factors in the treatment of women. An adherence scale/manual was developed and implemented and will allow for replication.

  14. PUBLIC RELATION BASED MODEL OF INTEGRATED MARKETING COMMUNICATIONS

    Directory of Open Access Journals (Sweden)

    Ljupka Naumovska

    2016-12-01

    Full Text Available The marketing communications industry and theory are facing rapid changes in accordance with global business and society fluctuations. Global and local market conditions are constantly varying and thus creating hardly predictable environment. The most implemented tool for marketing communications – advertising, is losing its power for effective communications; customers are becoming over-advertised and resistant to traditional advertising stimuli. Advertising, as one-way communication mass media tool is no longer effective as previously, hence can no longer fulfill the role of leading marketing mix tool. Therefore, the necessity for altering the structure of the traditional marketing communication mix elements, emphasizing the role of other elements but advertising, with more personalized and interactive functions. One method for improvement of marketing communication’s mix efficiency is by reallocation the leading role of advertising with public relations. The practice of public relations tools can ensure higher level of transparency in internal and external organizational communications and thus can certify more effective marketing communication. The theoretical research is supported with qualitative research of business segment by conducting a detailed interview for the marketing communication practice.

  15. Diabetic mouse model of orthopaedic implant-related Staphylococcus aureus infection.

    Science.gov (United States)

    Lovati, Arianna B; Drago, Lorenzo; Monti, Lorenzo; De Vecchi, Elena; Previdi, Sara; Banfi, Giuseppe; Romanò, Carlo L

    2013-01-01

    Periprosthetic bacterial infections represent one of the most challenging orthopaedic complications that often require implant removal and surgical debridement and carry high social and economical costs. Diabetes is one of the most relevant risk factors of implant-related infection and its clinical occurrence is growing worldwide. The aim of the present study was to test a model of implant-related infection in the diabetic mouse, with a view to allow further investigation on the relative efficacy of prevention and treatment options in diabetic and non-diabetic individuals. A cohort of diabetic NOD/ShiLtJ mice was compared with non-diabetic CD1 mice as an in vivo model of S. aureus orthopaedic infection of bone and soft tissues after femur intramedullary pin implantation. We tested control and infected groups with 1×10(3) colony-forming units of S. aureus ATCC 25923 strain injected in the implant site. At 4 weeks post-inoculation, host response to infection, microbial biofilm formation, and bone damage were assessed by traditional diagnostic parameters (bacterial culture, C-reactive protein and white blood cell count), histological analysis and imaging techniques (micro computed tomography and scanning electron microscopy). Unlike the controls and the CD1 mice, all the diabetic mice challenged with a single inoculum of S. aureus displayed severe osteomyelitic changes around the implant. Our findings demonstrate for the first time that the diabetic mouse can be successfully used in a model of orthopaedic implant-related infection. Furthermore, the same bacteria inoculum induced periprosthetic infection in all the diabetic mice but not in the controls. This animal model of implant-related infection in diabetes may be a useful tool to test in vivo treatments in diabetic and non-diabetic individuals.

  16. Diabetic mouse model of orthopaedic implant-related Staphylococcus aureus infection.

    Directory of Open Access Journals (Sweden)

    Arianna B Lovati

    Full Text Available BACKGROUND: Periprosthetic bacterial infections represent one of the most challenging orthopaedic complications that often require implant removal and surgical debridement and carry high social and economical costs. Diabetes is one of the most relevant risk factors of implant-related infection and its clinical occurrence is growing worldwide. The aim of the present study was to test a model of implant-related infection in the diabetic mouse, with a view to allow further investigation on the relative efficacy of prevention and treatment options in diabetic and non-diabetic individuals. METHODOLOGY: A cohort of diabetic NOD/ShiLtJ mice was compared with non-diabetic CD1 mice as an in vivo model of S. aureus orthopaedic infection of bone and soft tissues after femur intramedullary pin implantation. We tested control and infected groups with 1×10(3 colony-forming units of S. aureus ATCC 25923 strain injected in the implant site. At 4 weeks post-inoculation, host response to infection, microbial biofilm formation, and bone damage were assessed by traditional diagnostic parameters (bacterial culture, C-reactive protein and white blood cell count, histological analysis and imaging techniques (micro computed tomography and scanning electron microscopy. RESULTS: Unlike the controls and the CD1 mice, all the diabetic mice challenged with a single inoculum of S. aureus displayed severe osteomyelitic changes around the implant. CONCLUSIONS: Our findings demonstrate for the first time that the diabetic mouse can be successfully used in a model of orthopaedic implant-related infection. Furthermore, the same bacteria inoculum induced periprosthetic infection in all the diabetic mice but not in the controls. This animal model of implant-related infection in diabetes may be a useful tool to test in vivo treatments in diabetic and non-diabetic individuals.

  17. Characterizing two-phase flow relative permeabilities in chemicalflooding using a pore-scale network model

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Qingjie; Shen, Pingping; Wu, Yu-Shu

    2004-03-15

    A dynamic pore-scale network model is presented for investigating the effects of interfacial tension and oil-water viscosity on relative permeability during chemical flooding. This model takes into account both viscous and capillary forces in analyzing the impact of chemical properties on flow behavior or displacement configuration, as opposed to the conventional or invasion percolation algorithm which incorporates capillary pressure only. The study results indicate that both water and oil relative-permeability curves are dependent strongly on interfacial tension as well as an oil-water viscosity ratio. In particular, water and oil relative-permeability curves are both found to shift upward as interfacial tension is reduced, and they both tend to become linear versus saturation once interfacial tension is at low values. In addition, the oil-water viscosity ratio appears to have only a small effect under conditions of high interfacial tension. When the interfacial tension is low, however, water relative permeability decreases more rapidly (with the increase in the aqueous-phase viscosity) than oil relative permeability. The breakthrough saturation of the aqueous phase during chemical flooding tends to decrease with the reduction of interfacial tension and may also be affected by the oil-water viscosity ratio.

  18. A Novel Study: A Situation Model Analysis of Reading Times

    Science.gov (United States)

    McNerney, M. Windy; Goodwin, Kerri A.; Radvansky, Gabriel A.

    2011-01-01

    One of the basic findings on situation models and language comprehension is that reading times are affected by the changing event structure in a text. However, many studies have traditionally used multiple, relatively short texts, in which there is little event consistency across the texts. It is unclear to what extent such changes will be…

  19. Study of primitive universe in the Bianchi IX model

    International Nuclear Information System (INIS)

    Matsas, G.E.A.

    1988-03-01

    The theory of general relativity is used to study the homogeneous cosmological model Bianch IX with isometry group SO(3) near the cosmological singularity. The Bogoyavlenskii-Novikov formalism to explain the anusual behaviour of the Liapunov exponent associated with this chaotic system, is introduced. (author) [pt

  20. The Human-Computer Domain Relation in UX Models

    DEFF Research Database (Denmark)

    Clemmensen, Torkil

    This paper argues that the conceptualization of the human, the computer and the domain of use in competing lines of UX research have problematic similarities and superficial differences. The paper qualitatively analyses concepts and models in five research papers that together represent two...... influential lines of UX research: aesthetics and temporal UX, and two use situations: using a website and starting to use a smartphone. The results suggest that the two lines of UX research share a focus on users’ evaluative judgments of technology, both focuses on product qualities rather than activity...... domains, give little details about users, and treat human-computer interaction as perception. The conclusion gives similarities and differences between the approaches to UX. The implications for theory building are indicated....

  1. Renal Transplant Recipients: The Factors Related to Immunosuppressive Medication Adherence Based on the Health Belief Model.

    Science.gov (United States)

    Kung, Pen-Chen; Yeh, Mei Chang; Lai, Ming-Kuen; Liu, Hsueh-Erh

    2017-10-01

    Kidney transplant failures are caused primarily by lack of adherence to immunosuppressive medication regimens by patients after transplantation. A number of studies have indicated that health-related beliefs are an effective predictor of health-related behavior. The aim of this study is to understand the influence of the personal characteristics and health-related beliefs of patients on adherence to treatment with immunosuppressive medication based on the Health Belief Model. This cross-sectional study distributed questionnaires to patients who had been recruited via purposive sampling at one medical center in Taipei. All of the potential participants had undergone kidney transplantation at least 6 months previously. The self-developed questionnaire collected data in three areas: personal characteristics, health-related beliefs regarding transplant rejection, and adherence to the immunosuppressive medication regimen. One hundred twenty-two valid questionnaires were received. The collected data were analyzed using descriptive statistics, independent t test, one-way analysis of variance, Pearson's correlation, and multiple regression. Participants who had received dialysis treatment or had experienced rejection perceived susceptibility to rejection more strongly than those who had not. Participants who had undergone transplantation in Taiwan, had experienced more drug-related symptoms, or had contracted severe to extremely severe infections in the past showed lower rates of adherence to treatment with immunosuppressive medication. Adherence to medication regimens correlated negatively with length of time since transplantation. Length of time since transplantation, drug-related symptoms, perceived susceptibility to rejection, and perceived benefits of treatment were identified as major predictors of adherence to immunosuppressive medication regimens. The results partially conformed to the concepts of the Health Belief Model. Perceived susceptibility to rejection and

  2. Components in models of learning: Different operationalisations and relations between components

    Directory of Open Access Journals (Sweden)

    Mirkov Snežana

    2013-01-01

    Full Text Available This paper provides the presentation of different operationalisations of components in different models of learning. Special emphasis is on the empirical verifications of relations between components. Starting from the research of congruence between learning motives and strategies, underlying the general model of school learning that comprises different approaches to learning, we have analyzed the empirical verifications of factor structure of instruments containing the scales of motives and learning strategies corresponding to these motives. Considering the problems in the conceptualization of the achievement approach to learning, we have discussed the ways of operational sing the goal orientations and exploring their role in using learning strategies, especially within the model of the regulation of constructive learning processes. This model has served as the basis for researching learning styles that are the combination of a large number of components. Complex relations between the components point to the need for further investigation of the constructs involved in various models. We have discussed the findings and implications of the studies of relations between the components involved in different models, especially between learning motives/goals and learning strategies. We have analyzed the role of regulation in the learning process, whose elaboration, as indicated by empirical findings, can contribute to a more precise operationalisation of certain learning components. [Projekat Ministarstva nauke Republike Srbije, br. 47008: Unapređivanje kvaliteta i dostupnosti obrazovanja u procesima modernizacije Srbije i br. 179034: Od podsticanja inicijative, saradnje i stvaralaštva u obrazovanju do novih uloga i identiteta u društvu

  3. A methodology for modelling energy-related human behaviour: Application to window opening behaviour in residential buildings

    DEFF Research Database (Denmark)

    Fabi, Valentina; Andersen, Rune Korsholm; Corgnati, Stefano P.

    2013-01-01

    . The occupant behaviour related to the building control potentialities is a very complex process that has been studied only in the last years with some focuses related to natural ventilation (window opening behaviour), space heating energy demand (in particular the adjustments in the temperature set...... for modelling the human behaviour related to the control of indoor environment. The procedure is applied at models of occupants’ interactions with windows (opening and closing behaviour). Models of occupants’ window opening behaviour were inferred based on measurements and implemented in a simulation program...

  4. Quality Systems. A Thermodynamics-Related Interpretive Model

    Directory of Open Access Journals (Sweden)

    Stefano A. Lollai

    2017-08-01

    Full Text Available In the present paper, a Quality Systems Theory is presented. Certifiable Quality Systems are treated and interpreted in accordance with a Thermodynamics-based approach. Analysis is also conducted on the relationship between Quality Management Systems (QMSs and systems theories. A measure of entropy is proposed for QMSs, including a virtual document entropy and an entropy linked to processes and organisation. QMSs are also interpreted in light of Cybernetics, and interrelations between Information Theory and quality are also highlighted. A measure for the information content of quality documents is proposed. Such parameters can be used as adequacy indices for QMSs. From the discussed approach, suggestions for organising QMSs are also derived. Further interpretive thermodynamic-based criteria for QMSs are also proposed. The work represents the first attempt to treat quality organisational systems according to a thermodynamics-related approach. At this stage, no data are available to compare statements in the paper.

  5. Studi Model Penerimaan Tehnologi (Technology Acceptance Model) Novice Accountant

    OpenAIRE

    Rustiana, Rustiana

    2006-01-01

    This study investigates adoption or application of behavior information technologyacceptance. Davis' Technology Acceptance Model is employed to explain perceived usefulness, perceived ease of use, and intention to use in information systems. The respondents were 228 accounting students in management information system. Data was collected by questionnaire and then analyzed by using linear regression analysis and independent t-test. The results are in line with most of the hypotheses, only hypo...

  6. The importance of statistical modelling in clinical research : Comparing multidimensional Rasch-, structural equation and linear regression models for analyzing the depression of relatives of psychiatric patients.

    Science.gov (United States)

    Alexandrowicz, Rainer W; Jahn, Rebecca; Friedrich, Fabian; Unger, Anne

    2016-06-01

    Various studies have shown that caregiving relatives of schizophrenic patients are at risk of suffering from depression. These studies differ with respect to the applied statistical methods, which could influence the findings. Therefore, the present study analyzes to which extent different methods may cause differing results. The present study contrasts by means of one data set the results of three different modelling approaches, Rasch Modelling (RM), Structural Equation Modelling (SEM), and Linear Regression Modelling (LRM). The results of the three models varied considerably, reflecting the different assumptions of the respective models. Latent trait models (i. e., RM and SEM) generally provide more convincing results by correcting for measurement error and the RM specifically proves superior for it treats ordered categorical data most adequately.

  7. Person perception as a function of interpersonal relations: The role of the Relation-Pattern Model (RPM)

    OpenAIRE

    Peeters, Guido

    1981-01-01

    The "Relation Pattern Model" (RPM) maps information that configurations of interpersonal relations imply about individuals within the configuration. This "implied information" varies according as individuals are conceived of either in self-other terms or in terms of singular persons (e.g.: proper names). Illustrative examples as well as research data show that the RPM accounts for a good deal of the variability among impressions perceivers form of people on the basis of information about inte...

  8. A twin study of perfume-related respiratory symptoms

    DEFF Research Database (Denmark)

    Elberling, J; Lerbaek, A; Kyvik, K O

    2009-01-01

    Respiratory symptoms from environmental perfume exposure are main complaints in patients with multiple chemical sensitivities and often coincide with asthma and or eczema. In this population-based twin study we estimate the heritability of respiratory symptoms related to perfume and if co......-occurrences of the symptoms in asthma, atopic dermatitis, hand eczema or contact allergy are influenced by environmental or genetic factors common with these diseases. In total 4,128 twin individuals (82%) responded to a questionnaire. The heritability of respiratory symptoms related to perfume is 0.35, 95%CI 0.......14-0.54. Significant associations (pperfume-related respiratory symptoms and asthma, atopic dermatitis, hand eczema or contact allergy are not attributable to shared genetic or shared environmental/familial factors, except possibly for atopic dermatitis where genetic pleiotropy with respiratory symptoms...

  9. A twin study of perfume-related respiratory symptoms.

    Science.gov (United States)

    Elberling, J; Lerbaek, A; Kyvik, K O; Hjelmborg, J

    2009-11-01

    Respiratory symptoms from environmental perfume exposure are main complaints in patients with multiple chemical sensitivities and often coincide with asthma and or eczema. In this population-based twin study we estimate the heritability of respiratory symptoms related to perfume and if co-occurrences of the symptoms in asthma, atopic dermatitis, hand eczema or contact allergy are influenced by environmental or genetic factors common with these diseases. In total 4,128 twin individuals (82%) responded to a questionnaire. The heritability of respiratory symptoms related to perfume is 0.35, 95%CI 0.14-0.54. Significant associations (pperfume-related respiratory symptoms and asthma, atopic dermatitis, hand eczema or contact allergy are not attributable to shared genetic or shared environmental/familial factors, except possibly for atopic dermatitis where genetic pleiotropy with respiratory symptoms to perfume is suggested by an estimated genetic correlation of 0.39, 95%CI 0.09-0.72.

  10. Relative mass distributions of neutron-rich thermally fissile nuclei within a statistical model

    Science.gov (United States)

    Kumar, Bharat; Kannan, M. T. Senthil; Balasubramaniam, M.; Agrawal, B. K.; Patra, S. K.

    2017-09-01

    We study the binary mass distribution for the recently predicted thermally fissile neutron-rich uranium and thorium nuclei using a statistical model. The level density parameters needed for the study are evaluated from the excitation energies of the temperature-dependent relativistic mean field formalism. The excitation energy and the level density parameter for a given temperature are employed in the convolution integral method to obtain the probability of the particular fragmentation. As representative cases, we present the results for the binary yields of 250U and 254Th. The relative yields are presented for three different temperatures: T =1 , 2, and 3 MeV.

  11. Three Norwegian Varieties of a Nordic Model — A Historical Perspective on Working Life Relations

    Directory of Open Access Journals (Sweden)

    Jan Heiret

    2012-11-01

    Full Text Available Through the use of a historical perspective, the aim of this article is to discuss and clarify the concurrent and conflicting interests and norms that have characterized the establishment and development of important institutions in Norwegian working life. The article concentrates on collective bargaining systems, the arrangements for codetermination, and the working environment regulations in both the public and private sector, which are regarded as the main institutions in the Norwegian and Nordic models of working life relations. The article is structured by an analytical distinction between three different historical periods that have constituted three distinct versions of the Norwegian model. By presenting a historical synthesis of Norwegian experiences, the article is a contribution to the ongoing debate on the varieties in the Nordic model, as to further comparisons and broader transnational studies.

  12. Description and evaluation of the Model for Ozone and Related chemical Tracers, version 4 (MOZART-4

    Directory of Open Access Journals (Sweden)

    L. K. Emmons

    2010-01-01

    Full Text Available The Model for Ozone and Related chemical Tracers, version 4 (MOZART-4 is an offline global chemical transport model particularly suited for studies of the troposphere. The updates of the model from its previous version MOZART-2 are described, including an expansion of the chemical mechanism to include more detailed hydrocarbon chemistry and bulk aerosols. Online calculations of a number of processes, such as dry deposition, emissions of isoprene and monoterpenes and photolysis frequencies, are now included. Results from an eight-year simulation (2000–2007 are presented and evaluated. The MOZART-4 source code and standard input files are available for download from the NCAR Community Data Portal (http://cdp.ucar.edu.

  13. Mixed models in cerebral ischemia study

    Directory of Open Access Journals (Sweden)

    Matheus Henrique Dal Molin Ribeiro

    2016-06-01

    Full Text Available The data modeling from longitudinal studies stands out in the current scientific scenario, especially in the areas of health and biological sciences, which induces a correlation between measurements for the same observed unit. Thus, the modeling of the intra-individual dependency is required through the choice of a covariance structure that is able to receive and accommodate the sample variability. However, the lack of methodology for correlated data analysis may result in an increased occurrence of type I or type II errors and underestimate/overestimate the standard errors of the model estimates. In the present study, a Gaussian mixed model was adopted for the variable response latency of an experiment investigating the memory deficits in animals subjected to cerebral ischemia when treated with fish oil (FO. The model parameters estimation was based on maximum likelihood methods. Based on the restricted likelihood ratio test and information criteria, the autoregressive covariance matrix was adopted for errors. The diagnostic analyses for the model were satisfactory, since basic assumptions and results obtained corroborate with biological evidence; that is, the effectiveness of the FO treatment to alleviate the cognitive effects caused by cerebral ischemia was found.

  14. Investment Frictions and the Relative Price of Investment Goods in an Open Economy Model

    OpenAIRE

    Parantap Basu; Christoph Thoenissen

    2007-01-01

    Is the relative price of investment goods a good proxy for investment frictions? We analyze investment frictions in an open economy, flexible price, two-country model and show that when the relative price of investment goods is endogenously determined in such a model, the relative price of investment can actually rise in response to a reduction in investment frictions. Only when the model is driven by TFP shocks do we observe a data congruent negative correlation between investment and the re...

  15. Process modeling study of the CIF incinerator

    International Nuclear Information System (INIS)

    Hang, T.

    1995-01-01

    The Savannah River Site (SRS) plans to begin operating the Consolidated Incineration Facility (CIF) in 1996. The CIF will treat liquid and solid low-level radioactive, mixed and RCRA hazardous wastes generated at SRS. In addition to experimental test programs, process modeling was applied to provide guidance in areas of safety, environmental regulation compliances, process improvement and optimization. A steady-state flowsheet model was used to calculate material/energy balances and to track key chemical constituents throughout the process units. Dynamic models were developed to predict the CIF transient characteristics in normal and abnormal operation scenarios. Predictions include the rotary kiln heat transfer, dynamic responses of the CIF to fluctuations in the solid waste feed or upsets in the system equipments, performance of the control system, air inleakage in the kiln, etc. This paper reviews the modeling study performed to assist in the deflagration risk assessment

  16. Loop Corrections in Very Special Relativity Standard Model

    Science.gov (United States)

    Alfaro, Jorge

    2018-01-01

    In this talk we want to study one-loop corrections in VSRSM. In particular, we use the new Sim(2)-invariant dimensional regularization to compute one-loop corrections to the Effective Action in the subsector of the VSRSM that describe the interaction of photons with charged leptons. New stringent bounds for the masses of ve and vµ are obtained.

  17. A Note on the Relation between Factor Analytic and Item Response Theory Models

    Science.gov (United States)

    Kamata, Akihito; Bauer, Daniel J.

    2008-01-01

    The relations among several alternative parameterizations of the binary factor analysis model and the 2-parameter item response theory model are discussed. It is pointed out that different parameterizations of factor analysis model parameters can be transformed into item response model theory parameters, and general formulas are provided.…

  18. Study on the mortality in Ecuador related to dietary factors.

    Science.gov (United States)

    Neira-Mosquera, Juan Alejandro; Pérez-Rodríguez, Fernando; Sánchez-Llaguno, Sungey; Moreno Rojas, Rafael

    2013-01-01

    Diet is an important factor related to the development of numerous diseases. In developing countries like Ecuador, this aspect is not considered as priority however, the study of the incidence of certain diet-related diseases could help to assess consumption habits of a country from a Public Health perspective and support national nutrition policies and programs. The objective the present study is to investigate the mortality rate of certain diet-related diseases in Ecuador and its possible relationship with Ecuadorian consumption habits. For that, mortality rates (2001-2008) associated with five different disease groups related to dietary factors (cancer of colon, cerebrovascular diseases, cardiovascular diseases, diabetes mellitus and liver diseases) were collected, analyzed and compared to consumption patterns in Ecuador. According to results, Ecuador has a low level of cancer of colon in comparison with developed countries (e.g. Spain). The group with the highest number of deaths corresponded to cardiovascular diseases followed by cerebrovascular diseases. The mortality study per province revealed that Amazonian provinces showed few deaths in relation to other provinces in Ecuador. This could be due to different factors including fails in the disease surveillance information systems, environmental factors and consumption patterns. In this sense, further investigation on native products consumption such as "chontaduro" might help to find valuable foods contributing to healthier Ecuadorian diet. These results, though preliminary, evidence that a major effort should be made by national and international organisations to collect data on consumption patterns and nutritional aspects of the Ecuadorian population in order to better support the development of effective food security and nutrition policies. Copyright © AULA MEDICA EDICIONES 2013. Published by AULA MEDICA. All rights reserved.

  19. A Case Study Application Of Time Study Model In Paint ...

    African Journals Online (AJOL)

    This paper presents a case study in the development and application of a time study model in a paint manufacturing company. The organization specializes in the production of different grades of paint and paint containers. The paint production activities include; weighing of raw materials, drying of raw materials, dissolving ...

  20. Does Distraction Reduce the Alcohol-Aggression Relation? A Cognitive and Behavioral Test of the Attention-Allocation Model

    Science.gov (United States)

    Gallagher, Kathryn E.; Parrott, Dominic J.

    2011-01-01

    Objective: This study provided the first direct test of the cognitive underpinnings of the attention-allocation model and attempted to replicate and extend past behavioral findings for this model as an explanation for alcohol-related aggression. Method: A diverse community sample (55% African American) of men (N = 159) between 21 and 35 years of…

  1. The Role of the Fear-avoidance Model in Female Workers With Neck-shoulder Pain related to Computer Work

    NARCIS (Netherlands)

    Huis in 't Veld, M.H.A.; Vollenbroek-Hutten, Miriam Marie Rosé; Groothuis-Oudshoorn, Catharina Gerarda Maria; Hermens, Hermanus J.

    Objective: This study explores the fear-avoidance model in a sample of women with neck-shoulder pain related to computer work who were still functioning at the workplace. Exploring this model in this population could produce starting points for new treatment approaches in occupational health.

  2. Towards a quality-controlled and accessible Pitzer model for seawater and related systems

    Directory of Open Access Journals (Sweden)

    David Turner

    2016-09-01

    Full Text Available We elaborate the need for a quality-controlled chemical speciation model for seawater and related natural waters, work which forms the major focus of SCOR Working Group 145. Model development is based on Pitzer equations for the seawater electrolyte and trace components. These equations can be used to calculate activities of dissolved ions and molecules and, in combination with thermodynamic equilibrium constants, chemical speciation. The major tasks to be addressed are ensuring internal consistency of the Pitzer model parameters (expressing the interactions between pairs and triplets of species, which ultimately determines the calculated activities, assessing uncertainties, and identifying important data gaps that should be addressed by new measurements. It is recognised that natural organic matter plays an important role in many aquatic ecosystems, and options for including this material in a Pitzer-based model are discussed. The process of model development begins with the core components which include the seawater electrolyte and the weak acids controlling pH. This core model can then be expanded by incorporating additional chemical components, changing the standard seawater composition and/or broadening the range of temperature and pressure, without compromising its validity. Seven important areas of application are identified: open ocean acidification; micro-nutrient biogeochemistry and geochemical tracers; micro-nutrient behaviour in laboratory studies; water quality in coastal and estuarine waters; cycling of nutrients and trace metals in pore waters; chemical equilibria in hydrothermal systems; brines and salt lakes.

  3. Evaluating social influence relations: an item-response-modeling approach:

    OpenAIRE

    Schwenk, Gero

    2009-01-01

    Subject of this paper is the measurement of social influence in social networks. The theoretical point of departure is twofold. First, focus is on cognitive processing of perceived influence. Second, three distinct dimensions of social influence are considered: persuasion, authority and coercion. Combining these considerations with Item Response Theory methods, questionnaire-type measurement instruments are proposed. These instruments are employed in a closed network case study where applicab...

  4. A study of the drift function and relative scale factors based on two juxtaposed CG5 relative gravimeters.

    Science.gov (United States)

    Nielsen, Jens Emil; Strykowski, Gabriel

    2014-05-01

    A time-wise drift of one standard relative gravimeter can be modelled by linking the measurements of a gravity survey to high accuracy gravity stations with known gravity values. Alternatively, the measurements can be performed in one station with not necessarily known, but a constant gravity value. In both cases, and prior to drift function estimation, the gravity measurements should be corrected for systematics caused by the tidal accelerations. Typically the time-wise drift is modelled by a linear function. For Scintrex CG5 this linear drift is particularly strong and significant. We have performed long time series measurements (weeks and months) using two juxtaposed CG5 instruments on our new absolute gravity station at the Technical University of Denmark. The instruments are only few decimetres apart, so it is reasonable to assume that the true tidal acceleration on both gravimeters is the same. However, the signature of the tidal components is in principle scaled by a scaling factor for each gravimeter relating the differences in the counter reading values to the gravity differences in mGals. For Scintrex CG5 this scaling factor is close to one. Knowing the position of our gravimeters the available tidal model yields a time-wise signature of the tidal accelerations on both gravimeters. The above setup can be used to decompose the gravity measurements into the following constituencies: • The tidal signal • The relative scale factor between the two gravimeters • The individual drift function for each gravimeter • The noise Concerning the individual drift function for each gravimeter it is only for short time windows that it can be regarded linear. For wider time windows there is a significant 2nd order component of the drift function. In our poster we will discuss the above decomposition and study the appropriate drift model for different widths of the time-window and its stability in time.

  5. Suprathreshold heat pain response predicts activity-related pain, but not rest-related pain, in an exercise-induced injury model.

    Directory of Open Access Journals (Sweden)

    Rogelio A Coronado

    Full Text Available Exercise-induced injury models are advantageous for studying pain since the onset of pain is controlled and both pre-injury and post-injury factors can be utilized as explanatory variables or predictors. In these studies, rest-related pain is often considered the primary dependent variable or outcome, as opposed to a measure of activity-related pain. Additionally, few studies include pain sensitivity measures as predictors. In this study, we examined the influence of pre-injury and post-injury factors, including pain sensitivity, for induced rest and activity-related pain following exercise induced muscle injury. The overall goal of this investigation was to determine if there were convergent or divergent predictors of rest and activity-related pain. One hundred forty-three participants provided demographic, psychological, and pain sensitivity information and underwent a standard fatigue trial of resistance exercise to induce injury of the dominant shoulder. Pain at rest and during active and resisted shoulder motion were measured at 48- and 96-hours post-injury. Separate hierarchical models were generated for assessing the influence of pre-injury and post-injury factors on 48- and 96-hour rest-related and activity-related pain. Overall, we did not find a universal predictor of pain across all models. However, pre-injury and post-injury suprathreshold heat pain response (SHPR, a pain sensitivity measure, was a consistent predictor of activity-related pain, even after controlling for known psychological factors. These results suggest there is differential prediction of pain. A measure of pain sensitivity such as SHPR appears more influential for activity-related pain, but not rest-related pain, and may reflect different underlying processes involved during pain appraisal.

  6. Quantitative Structure-Activity Relationships and Docking Studies of Calcitonin Gene-Related Peptide Antagonists

    DEFF Research Database (Denmark)

    Jenssen, Håvard; Mehrabian, Mohadeseh; Kyani, Anahita

    2012-01-01

    of calcitonin gene-related peptide antagonists was performed using a panel of physicochemical descriptors. The computational studies evaluated different variable selection techniques and demonstrated shuffling stepwise multiple linear regression to be superior over genetic algorithm-multiple linear regression....... The linear quantitative structure-activity relationship model revealed better statistical parameters of cross-validation in comparison with the non-linear support vector regression technique. Implementing only five peptide descriptors into this linear quantitative structure-activity relationship model...

  7. A predictive model of health-related quality of life in young adult survivors of childhood cancer

    NARCIS (Netherlands)

    Maurice-Stam, H.; Oort, F.J.; Last, B.F.; Grootenhuis, M.A.

    2009-01-01

    MAURICE-STAM H., OORT F.J., LAST B.F. & GROOTENHUIS M.A. (2009) European Journal of Cancer Care 18, 339-349A predictive model of health-related quality of life in young adult survivors of childhood cancer This study aimed to examine factors that affect survivors' health-related quality of life

  8. The Relation between Metacognition and Depressive Symptoms in Preadolescents with Learning Disabilities: Data in Support of Borkowski's Model.

    Science.gov (United States)

    Palladino, Paola; Poli, Paola; Masi, Gabriele; Marcheschi, Mara

    2000-01-01

    This study compared 28 preadolescents, either with or without learning disabilities (LD). Students with LD had less effective monitoring skills, lower attributions to effort, and a wider range of depressive symptoms. Results are discussed in relation to Borkowski's model that relates behavioral patterns of children facing school tasks with…

  9. On a relation between massive Yang-Mills theories and dual string models

    International Nuclear Information System (INIS)

    Mickelsson, J.

    1983-01-01

    The relations between mass terms in Yang-Mills theories, projective representations of the group of gauge transformations, boundary conditions on vector potentials and Schwinger terms in local charge algebra commutation relations are discussed. The commutation relations (with Schwinger terms) are similar to the current algebra commutation relations of the SU(N) extended dual string model. (orig.)

  10. Study of Relation between Physical Activity and Preterm Birth

    Directory of Open Access Journals (Sweden)

    Mehran N.

    2012-04-01

    Full Text Available Background and Objectives: Preterm birth is the main cause of neonatal mortality and morbidity and the importance of knowing its causes is clear. Since the effect of physical activity on preterm birth is unknown and its prevention is the priority in health care, we decided to do this study with the aim of determining the relation between physical activity and preterm birth. Methods: In this case-control study, 300 pregnant women delivering in Izadi Hospital in Qom, Iran in the second half of 2008, selected through simple sampling. The data were collected using standard pregnancy physical activity questionnaire that categorizes the physical activity into 4 groups: work activities, home activities, transport activities and fun/exercise activities. The physical activity severity was calculated as MET (Metabolic Equivalence Test. Finally, the data were analyzed using descriptive and analytic (x2 and t test statistics. A p<0.05 was considered as significant.Results: The findings didn't show any significant relation between physical activity and preterm birth. In addition, in view of activity type, fun/exercise and work activities (respectively and in view of activity severity, sedentary and moderate activities (respectively were associated with higher, but insignificant rate of preterm birth. Among demographic factors, only gravidity of women was significantly associated with preterm birth.Conclusion: Although, in this study the significant relation between physical activity and preterm delivery wasn't observed, the same research with further sample is recommended.

  11. Cunqueiro in Catalonia: A Model of Intersystemic Relations

    Directory of Open Access Journals (Sweden)

    María Xesús Lama López

    2012-12-01

    Full Text Available Abstract: Panoramic study on Álvaro Cunqueiro and cunqueirian studies’ contact and exchanges with Catalan culture as a presentation of the context of intercultural relationships in which this monograph falls. The three areas dealt with, in a diverse criticism, are considered to be: personal relationships with Catalan cultural agents, allowing different collaborations and exchanges; professional relationships with the editorial and journalistic world, launching his work on the Spanish market; and repertorial relationships, shown in translations or in literary criticisms, made by the author of his own readings.

  12. Human-centred automation programme: review of experiment related studies

    International Nuclear Information System (INIS)

    Grimstad, Tone; Andresen, Gisle; Skjerve, Ann Britt Miberg

    2000-04-01

    Twenty-three empirical studies concerning automation and performance have been reviewed. The purposes of the review are to support experimental studies in the Human-Centred Automation (HCA) programme and to develop a general theory on HCA. Each study was reviewed with regard to twelve study characteristics: domain, type of study, purpose, definition of automation, variables, theoretical basis, models of operator performance, methods applied, experimental design, outcome, stated scope of results, strengths and limitations. Seven of the studies involved domain experts, the rest used students as participants. The majority of the articles originated from the aviation domain: only the study conducted in HAMMLAB considered process control in power plants. In the experimental studies, the independent variable was level of automation, or reliability of automation, while the most common dependent variables were workload, situation awareness, complacency, trust, and criteria of performance, e.g., number of correct responses or response time. Although the studies highlight important aspects of human-automation interaction, it is still unclear how system performance is affected. Nevertheless, the fact that many factors seem to be involved is taken as support for the system-oriented approach of the HCA programme. In conclusion, the review provides valuable input both to the design of experiments and to the development of a general theory. (Author). refs

  13. preliminary multidomain modelling and simulation study

    African Journals Online (AJOL)

    user

    PRELIMINARY MULTIDOMAIN MODELLING AND SIMULATION STUDY OF A. HORIZONTAL AXIS WIND TURBINE (HAWT) TOWER VIBRATION. I. lliyasu1, I. Iliyasu2, I. K. Tanimu3 and D. O Obada4. 1,4 DEPARTMENT OF MECHANICAL ENGINEERING, AHMADU BELLO UNIVERSITY, ZARIA, KADUNA STATE. NIGERIA.

  14. Parametric study for horizontal steam generator modelling

    Energy Technology Data Exchange (ETDEWEB)

    Ovtcharova, I. [Energoproekt, Sofia (Bulgaria)

    1995-12-31

    In the presentation some of the calculated results of horizontal steam generator PGV - 440 modelling with RELAP5/Mod3 are described. Two nodalization schemes have been used with different components in the steam dome. A study of parameters variation on the steam generator work and calculated results is made in cases with separator and branch.

  15. Nutritional variables and work-related accidents: a case-control study.

    Science.gov (United States)

    de Medeiros, M A T; Zangirolani, Lia Thieme Oikawa; Cordeiro, Ricardo Carlos; da Costa, Proença Rossana Pacheco; Diez-Garcia, Rosa Wanda

    2014-01-01

    Nutritional aspects are important for the prevention of diseases and disorders, and few studies have focused on the relationship between risk of work injury and nutritional variables. This study aimed to verify whether nutritional variables constitute risk factors for work-related accidents. 1,422 industrial workers (600 cases plus 822 controls). A case-control study was carried out in an industrial city in south-east Brazil. A multiple logistic regression model was adjusted using work-related accidents as the response variable and nutritional variables as predictors. The associations were assessed by Odds Ratio (OR), with a p-value work-related accidents were (a) attending formal education for an above average number of years (OR=0.91, pwork-related accidents. This indicates the need, during the formulation of policies for these kinds of government benefits, to include nutrition aspects in order to minimize work-related accidents risks.

  16. Dexpramipexole is ineffective in two models of ALS related neurodegeneration.

    Directory of Open Access Journals (Sweden)

    Fernando G Vieira

    Full Text Available Treatment options for people living with amyotrophic lateral sclerosis (ALS are limited and ineffective. Recently, dexpramipexole (RPPX was advanced into human ALS clinical trials. In the current studies, we investigated RPPX in two parallel screening systems: 1 appropriately powered, sibling-matched, gender-balanced survival efficacy screening in high-copy B6-SJL-SOD1G93A/Gur1 mice, and 2 high-content neuronal survival screening in primary rat cortical neurons transfected with wild-type human TDP43 or mutant human TDP43. In both cases, we exposed the test systems to RPPX levels approximating those achieved in human Phase II clinical investigations. In SOD1G93A mice, no effect was observed on neuromotor disease progression or survival. In primary cortical neurons transfected with either mutant or wild-type human TDP43, a marginally significant improvement in a single indicator of neuronal survival was observed, and only at the 10 µM RPPX treatment. These systems reflect both mutant SOD1- and TDP43-mediated forms of neurodegeneration. The systems also reflect both complex non-cell autonomous and neuronal cell autonomous disease mechanisms. The results of these experiments, taken in context with results produced by other molecules tested in both screening systems, do not argue positively for further study of RPPX in ALS.

  17. Dexpramipexole is ineffective in two models of ALS related neurodegeneration.

    Science.gov (United States)

    Vieira, Fernando G; LaDow, Eva; Moreno, Andy; Kidd, Joshua D; Levine, Beth; Thompson, Kenneth; Gill, Alan; Finkbeiner, Steven; Perrin, Steven

    2014-01-01

    Treatment options for people living with amyotrophic lateral sclerosis (ALS) are limited and ineffective. Recently, dexpramipexole (RPPX) was advanced into human ALS clinical trials. In the current studies, we investigated RPPX in two parallel screening systems: 1) appropriately powered, sibling-matched, gender-balanced survival efficacy screening in high-copy B6-SJL-SOD1G93A/Gur1 mice, and 2) high-content neuronal survival screening in primary rat cortical neurons transfected with wild-type human TDP43 or mutant human TDP43. In both cases, we exposed the test systems to RPPX levels approximating those achieved in human Phase II clinical investigations. In SOD1G93A mice, no effect was observed on neuromotor disease progression or survival. In primary cortical neurons transfected with either mutant or wild-type human TDP43, a marginally significant improvement in a single indicator of neuronal survival was observed, and only at the 10 µM RPPX treatment. These systems reflect both mutant SOD1- and TDP43-mediated forms of neurodegeneration. The systems also reflect both complex non-cell autonomous and neuronal cell autonomous disease mechanisms. The results of these experiments, taken in context with results produced by other molecules tested in both screening systems, do not argue positively for further study of RPPX in ALS.

  18. Drug-related celebrity deaths: A cross-sectional study.

    Science.gov (United States)

    Just, Johannes M; Bleckwenn, Markus; Schnakenberg, Rieke; Skatulla, Philipp; Weckbecker, Klaus

    2016-12-09

    Celebrities are at risk for premature mortality as well as drug-related death. Despite being a vulnerable patient group, celebrities influence people's health behaviours through biological, psychological and social processes. Therefore, celebrity endorsement of the topic could be one way to challenge the current "opioid endemic". Our aim was to better understand the factors surrounding drug-related celebrity deaths by investigating the incidence as well as substances used between 1970 and 2015 using a cross-sectional study design. We searched public databases for drug-related celebrity deaths between 1970 and 2015. They were categorized for sex, profession, age at death, year of death and substances involved. The main outcome measures are descriptive values including number of drug deaths per year and substances involved. Secondary outcome measures are analytical questions to examine whether and which factors influence age at death and year of death (e.g. type of substance use disorder). We identified 220 celebrities who died a drug-related death with a clear indication of involved substances between 1970 and 2015. The average age at death was 38.6 years; 75% were male. Most celebrities died between the age of 25 and 40. The number of drug-related deaths increased in the 21st century, with a significant increase in the use of prescription opioids. Deaths involving prescription opioids and heroin were associated with a significantly lower mean age at death compared to deaths where these substances were not involved. Compared to the 20th century, the total number of celebrities who died from a drug-related death in the 21st century increased, possibly due to an increased involvement of prescription opioids. Negative effects on individual health decisions of celebrity's followers could be the result.

  19. A Privacy Preservation Model for Health-Related Social Networking Sites

    Science.gov (United States)

    2015-01-01

    The increasing use of social networking sites (SNS) in health care has resulted in a growing number of individuals posting personal health information online. These sites may disclose users' health information to many different individuals and organizations and mine it for a variety of commercial and research purposes, yet the revelation of personal health information to unauthorized individuals or entities brings a concomitant concern of greater risk for loss of privacy among users. Many users join multiple social networks for different purposes and enter personal and other specific information covering social, professional, and health domains into other websites. Integration of multiple online and real social networks makes the users vulnerable to unintentional and intentional security threats and misuse. This paper analyzes the privacy and security characteristics of leading health-related SNS. It presents a threat model and identifies the most important threats to users and SNS providers. Building on threat analysis and modeling, this paper presents a privacy preservation model that incorporates individual self-protection and privacy-by-design approaches and uses the model to develop principles and countermeasures to protect user privacy. This study paves the way for analysis and design of privacy-preserving mechanisms on health-related SNS. PMID:26155953

  20. A Privacy Preservation Model for Health-Related Social Networking Sites.

    Science.gov (United States)

    Li, Jingquan

    2015-07-08

    The increasing use of social networking sites (SNS) in health care has resulted in a growing number of individuals posting personal health information online. These sites may disclose users' health information to many different individuals and organizations and mine it for a variety of commercial and research purposes, yet the revelation of personal health information to unauthorized individuals or entities brings a concomitant concern of greater risk for loss of privacy among users. Many users join multiple social networks for different purposes and enter personal and other specific information covering social, professional, and health domains into other websites. Integration of multiple online and real social networks makes the users vulnerable to unintentional and intentional security threats and misuse. This paper analyzes the privacy and security characteristics of leading health-related SNS. It presents a threat model and identifies the most important threats to users and SNS providers. Building on threat analysis and modeling, this paper presents a privacy preservation model that incorporates individual self-protection and privacy-by-design approaches and uses the model to develop principles and countermeasures to protect user privacy. This study paves the way for analysis and design of privacy-preserving mechanisms on health-related SNS.

  1. [Structural Equation Model of Health-Related Quality of Life in School Age Children with Asthma].

    Science.gov (United States)

    Kim, Yunsoo; Park, Ho Ran

    2018-02-01

    This study aimed to construct and test a hypothetical model of the quality of life of school-age children with asthma based on the health-related quality of life model by Wilson and Cleary. Data were collected from 205 pairs of pediatric outpatients diagnosed with asthma and their parents in Seoul and Gyeonggi-do from July 2016 to April 2017. The exogenous variables were asthma knowledge, number of accompanying allergic diseases, and social support. The endogenous variables were asthma self-efficacy, asthma symptom control, perceived health status, parental quality of life, and children's quality of life. For data analysis, descriptive statistics, factor analysis, and structural equation modeling were performed. Eighteen of the twenty-four hypotheses selected for the hypothetical model were attentive and supported statistically. Quality of life was explained by asthma self-efficacy, asthma symptom control, perceived health, parental quality of life, and asthma knowledge with 83.5%. Strategies for promoting self-efficacy and enforcing asthma knowledge will be helpful for the improvement of health-related quality of life with school-aged asthmatic children. © 2018 Korean Society of Nursing Science.

  2. Neural Network Inverse Model Control Strategy: Discrete-Time Stability Analysis for Relative Order Two Systems

    Directory of Open Access Journals (Sweden)

    M. A. Hussain

    2014-01-01

    Full Text Available This paper discusses the discrete-time stability analysis of a neural network inverse model control strategy for a relative order two nonlinear system. The analysis is done by representing the closed loop system in state space format and then analyzing the time derivative of the state trajectory using Lyapunov’s direct method. The analysis shows that the tracking output error of the states is confined to a ball in the neighborhood of the equilibrium point where the size of the ball is partly dependent on the accuracy of the neural network model acting as the controller. Simulation studies on the two-tank-in-series system were done to complement the stability analysis and to demonstrate some salient results of the study.

  3. Modelling approach for photochemical pollution studies

    International Nuclear Information System (INIS)

    Silibello, C.; Catenacci, G.; Calori, G.; Crapanzano, G.; Pirovano, G.

    1996-01-01

    The comprehension of the relationships between primary pollutants emissions and secondary pollutants concentration and deposition is necessary to design policies and strategies for the maintenance of a healthy environment. The use of mathematical models is a powerful tool to assess the effect of the emissions and of physical and chemical transformations of pollutants on air quality. A photochemical model, Calgrid, developed by CARB (California Air Resources Board), has been used to test the effect of different meteorological and air quality, scenarios on the ozone concentration levels. This way we can evaluate the influence of these conditions to determine the most important chemical species and reactions in atmosphere. The ozone levels are strongly related to the reactive hydrocarbons concentrations and to the solar radiation flux

  4. Prospective study related to the evolution of energy distribution networks. Needs of evolution of technical and organisational models of energy distribution networks with respect to energy transition scenarios in the Provence-Alpes-Cote d'Azur region. Part 1 - Hypotheses and perspectives, Part 2 - Needs of network evolution. Study related to the impact of the electric vehicle and of photovoltaic production on electric distribution networks - Case study for Provence-Alpes-Cote d'Azur

    International Nuclear Information System (INIS)

    Dauphin, Francois; Fontaine, Frederick

    2013-02-01

    The first part of this document aims at presenting perspectives of emergence of new energy production, consumption and storage sources, and their impacts on energy (electricity, gas, heat) distribution and transport networks. It is based on two scenarios: the regional climate-air-energy scheme, and the regional Negawatt scenario. The objective was to select a limited number of aspects: solutions enabling an optimal injection of biogas produced in the concerned region, development of photovoltaic energy and electric vehicles and their impact on the balance of medium-voltage and low-voltage networks, and smart grid technologies and their possible impact on the optimisation of electric network management. The second part reports the detailed study of these issues. It more particularly addresses technical impacts of different sectors on electric and gas networks in Provence-Alpes-Cote d'Azur, technical, economic and organisational assets of smart grid technologies, investments policies and implementation planning, and resulting evolutions for energy markets. Related documents published by ERDF and GrDF are provided

  5. Analysis of a mathematical model related to Czochralski crystal growth

    Directory of Open Access Journals (Sweden)

    Petr Knobloch

    1998-01-01

    Full Text Available This paper is devoted to the study of a stationary problem consisting of the Boussinesq approximation of the Navier–Stokes equations and two convection–diffusion equations for the temperature and concentration, respectively. The equations are considered in 3D and a velocity–pressure formulation of the Navier–Stokes equations is used. The problem is complicated by nonstandard boundary conditions for velocity on the liquid–gas interface where tangential surface forces proportional to surface gradients of temperature and concentration (Marangoni effect and zero normal component of the velocity are assumed. The velocity field is coupled through this boundary condition and through the buoyancy term in the Navier–Stokes equations with both the temperature and concentration fields. In this paper a weak formulation of the problem is stated and the existence of a weak solution is proved. For small data, the uniqueness of the solution is established.

  6. Investigating a New Model of Time-Related Academic Behavior: Procrastination and Timely Engagement by Motivational Orientation

    Science.gov (United States)

    Strunk, Kamden K.

    2012-01-01

    Scope and Method of Study: The purpose of this study was to examine the nature of time-related academic behavior (i.e., procrastination and timely engagement) in the academic context. Specifically, this study aimed to build a new model for understanding these behaviors in a motivational framework by using motivational orientation to frame these…

  7. Modeling residential water and related energy, carbon footprint and costs in California

    International Nuclear Information System (INIS)

    Escriva-Bou, Alvar; Lund, Jay R.; Pulido-Velazquez, Manuel

    2015-01-01

    Graphical abstract: - Highlights: • We model residential water use and related energy and GHG emissions in California. • Heterogeneity in use, spatial variability and water and energy rates are accounted. • Outdoor is more than 50% of water use but 80% of energy is used by faucet + shower. • Variability in water and energy prices affects willingness to adopt conservation. • Targeting high-use hoses and joint conservation policies are effective strategies. - Abstract: Starting from single-family household water end-use data, this study develops an end-use model for water-use and related energy and carbon footprint using probability distributions for parameters affecting water consumption in 10 local water utilities in California. Monte Carlo simulations are used to develop a large representative sample of households to describe variability in use, with water bills for each house for different utility rate structures. The water-related energy consumption for each household realization was obtained using an energy model based on the different water end-uses, assuming probability distributions for hot-water-use for each appliance and water heater characteristics. Spatial variability is incorporated to account for average air and household water inlet temperatures and price structures for each utility. Water-related energy costs are calculated using averaged energy price for each location. CO 2 emissions were derived from energy use using emission factors. Overall simulation runs assess the impact of several common conservation strategies on household water and energy use. Results show that single-family water-related CO 2 emissions are 2% of overall per capita emissions, and that managing water and energy jointly can significantly reduce state greenhouse gas emissions

  8. Studying and Modeling Vibration Transducers and Accelerometers

    Directory of Open Access Journals (Sweden)

    Katalin Ágoston

    2010-12-01

    Full Text Available This paper presents types and operating mode of vibration sensors. Piezoelectric sensing elements are often used in accelerometers. It will be investigate the structure and transfer function of the seismic mass type sensing element. The article presents how the piezoelectric sensing element works and how can be modeled with an electronic circuit. The transfer functions of the electronic circuit models are studied in Matlab and the results are presented. It will be presented the influence of the seismic mass on the accelerometer’s working frequency domain.

  9. Predictors and Health-Related Outcomes of Positive Body Image in Adolescent Girls: A Prospective Study

    Science.gov (United States)

    Andrew, Rachel; Tiggemann, Marika; Clark, Levina

    2016-01-01

    This study aimed to investigate prospective predictors and health-related outcomes of positive body image in adolescent girls. In so doing, the modified acceptance model of intuitive eating was also examined longitudinally. A sample of 298 girls aged 12 to 16 years completed a questionnaire containing measures of body appreciation, potential…

  10. The Earth's Shape and Movements: Teachers' Perception of the Relations Between Daily Observation and Scientific Models

    Science.gov (United States)

    Ferreira, Flávia Polati; Leite, Cristina

    2015-07-01

    The Earth’s shape and movements are some of the most common issues in official documents and research studies of astronomy education. Many didactic proposals suggest these issues within observational astronomy. Therefore, we present in this paper some of the main results of a research study of the teachers’ perception of the relations between the knowledge from daily observation and scientific models currently accepted about the “earth’s shape and movements”. Data were obtained in application of the didactic proposal during a teacher training course for teachers from São Paulo, have been constructed with the dynamics “Three Pedagogical Moments” and guided by some of the central ideas of the educator Paulo Freire. The results indicate that a small proportion of teachers seem to understand some of the relations of “apparent contradictions” and “limitations” with the concepts of spatiality, and many of them argued based only on vague phrases or "buzzwords", unconnected to the problem explored. The difficulties of teachers to relate elements of daily observation with scientific models seem to indicate a necessity to approach some these aspects with the astronomical knowledge in the teacher training courses.

  11. Relations of power in public schools: a case study

    Directory of Open Access Journals (Sweden)

    Maria Custódia Jorge Rocha

    2014-04-01

    Full Text Available In this paper, based on a few authors who see power as a substantive element – instituted power – and others who consider it as an action verb – instituting power (ROCHA, 2007 –, highlighting some types of power relevant in sociological and organizational research on schools, we present empirical data and institutional discourses, enabled by a case study of qualitative nature. Thus, we can say that relations of power in schools both allow the strengthening of hierarchical and asymmetrical relations of power that exist between institutional players and enable the creation of new “circles of power” that can be promptly activated or can be object of a modernization process held in a more or less generalized manner. This may be reinforced and introduced to players/students, our main target of study, as the most legitimate object, superseding all others but not canceling them. The key objective is to present school organization as a highly complex environment, especially when considered in the light of the multiple and cumulative relations of power that emerge and are materialized.

  12. The ARM-GCSS Intercomparison Study of Single-Column Models and Cloud System Models

    International Nuclear Information System (INIS)

    Cederwall, R.T.; Rodriques, D.J.; Krueger, S.K.; Randall, D.A.

    1999-01-01

    The Single-Column Model (SCM) Working Group (WC) and the Cloud Working Group (CWG) in the Atmospheric Radiation Measurement (ARM) Program have begun a collaboration with the GEWEX Cloud System Study (GCSS) WGs. The forcing data sets derived from the special ARM radiosonde measurements made during the SCM Intensive Observation Periods (IOPs), the wealth of cloud and related data sets collected by the ARM Program, and the ARM infrastructure support of the SCM WG are of great value to GCSS. In return, GCSS brings the efforts of an international group of cloud system modelers to bear on ARM data sets and ARM-related scientific questions. The first major activity of the ARM-GCSS collaboration is a model intercomparison study involving SCMs and cloud system models (CSMs), also known as cloud-resolving or cloud-ensemble models. The SCM methodologies developed in the ARM Program have matured to the point where an intercomparison will help identify the strengths and weaknesses of various approaches. CSM simulations will bring much additional information about clouds to evaluate cloud parameterizations used in the SCMs. CSMs and SCMs have been compared successfully in previous GCSS intercomparison studies for tropical conditions. The ARM Southern Great Plains (SGP) site offers an opportunity for GCSS to test their models in continental, mid-latitude conditions. The Summer 1997 SCM IOP has been chosen since it provides a wide range of summertime weather events that will be a challenging test of these models

  13. Studies on osteoporosis in Chile using isotope-related techniques

    International Nuclear Information System (INIS)

    Lobo, G.

    1998-01-01

    The relationship found between BMD of the lumbar spine with the anthropomorphic parameters (age, sex, body size and bone area) in the normal Chilean population studied, was different from the relationship found between BMD of both hips with the same parameters. To determine peak bone mass it is necessary to increase the number of individuals studied. This is specially true for BMD of the lumbar spine. It seems important for the correct interpretation of BMD studies to determine local values for normals, specially for the analysis of BMD in the lumbar spine, which is related to body and bone size. It is necessary to normalize the data base for anthropomorphic parameters specially in epidemiological studies. Knowledge of these parameters for the normal data base used in the different densitometers is highly desirable. There are some differences between this data base and that provided by Hologic, specially for spine in both sexes. This difference could be explained by size related factors. There is a correlation between osteocalcin levels and BMD in lumbar spine and both femoral necks only in women

  14. Characterizing poliovirus transmission and evolution: insights from modeling experiences with wild and vaccine-related polioviruses.

    Science.gov (United States)

    Duintjer Tebbens, Radboud J; Pallansch, Mark A; Kalkowska, Dominika A; Wassilak, Steven G F; Cochi, Stephen L; Thompson, Kimberly M

    2013-04-01

    With national and global health policymakers facing numerous complex decisions related to achieving and maintaining polio eradication, we expanded our previously developed dynamic poliovirus transmission model using information from an expert literature review process and including additional immunity states and the evolution of oral poliovirus vaccine (OPV). The model explicitly considers serotype differences and distinguishes fecal-oral and oropharyngeal transmission. We evaluated the model by simulating diverse historical experiences with polioviruses, including one country that eliminated wild poliovirus using both OPV and inactivated poliovirus vaccine (IPV) (USA), three importation outbreaks of wild poliovirus (Albania, the Netherlands, Tajikistan), one situation in which no circulating vaccine-derived polioviruses (cVDPVs) emerge despite annual OPV use and cessation (Cuba), three cVDPV outbreaks (Haiti, Madura Island in Indonesia, northern Nigeria), one area of current endemic circulation of all three serotypes (northern Nigeria), and one area with recent endemic circulation and subsequent elimination of multiple serotypes (northern India). We find that when sufficient information about the conditions exists, the model can reproduce the general behavior of poliovirus transmission and outbreaks while maintaining consistency in the generic model inputs. The assumption of spatially homogeneous mixing remains a significant limitation that affects the performance of the differential equation-based model when significant heterogeneities in immunity and mixing may exist. Further studies on OPV virus evolution and improved understanding of the mechanisms of mixing and transmission may help to better characterize poliovirus transmission in populations. Broad application of the model promises to offer insights in the context of global and national policy and economic models. © 2013 Society for Risk Analysis.

  15. Modelling drug-related morbidity in Sweden using an expert panel of physicians.

    Science.gov (United States)

    Hakkarainen, Katja M; Alström, Daniel; Hägg, Staffan; Carlsten, Anders; Gyllensten, Hanna

    2012-09-01

    In modelling studies using pharmacists' opinions, drug-related morbidity (DRM) and preventable DRM have been more common than in observational studies, and the resulting costs are extensive. Modelling studies' estimates may vary depending on informants' profession. The purpose of this modelling study was to estimate the proportion of patients with DRM and preventable DRM and the cost of illness (COI) of DRM in Sweden based on physicians' expert opinions. A conceptual model of DRM was modified from previous studies. Using a modified Delphi technique, a panel of physicians (n = 19) estimated the probabilities of DRM, preventable DRM, and clinical outcomes of DRM separately for outpatients and inpatients. DRM included new medical problems (adverse drug reactions, drug dependence, and intoxications by overdose) and therapeutic failure (insufficient effects of medicines, and morbidity due to untreated indication). A COI analysis included the direct costs of DRM. Physicians estimated that 51 ± 22% [mean ± standard deviation (SD)] of outpatients experience DRM and 12 ± 8% preventable DRM. Of inpatients, 54 ± 17% was estimated to experience DRM and 16 ± 7% preventable DRM. Of outpatients with DRM, 24 ± 11% was estimated to experience preventable DRM, whereas this proportion for inpatients was 31 ± 15%. The estimated COI was 376 euros per outpatient and 838 euros per inpatient. Swedish physicians estimated that every other outpatient and inpatient experiences DRM, which is often preventable and costly. As physicians' estimates on the proportion of patients with DRM were higher than in observational studies in restricted subpopulations, DRM may be more common in the general population than observational studies suggest.

  16. Born Global Firms: A Foreign Trade Related Study on Turkey

    Directory of Open Access Journals (Sweden)

    Aytaç GÖKMEN

    2013-11-01

    Full Text Available With the comprehensive advent in information and communication technologies and worldwide ease of transportation, the volume of international trade and business increased profoundly. Within this process, a Born Global Firm (BGF, right from its initiation, aims at creating competitive advantage by marketing a large volume of its products in various international markets by utilizing technological advances. Therefore, the rational behind the idea of BGF is to become an international firm in a short period of time and making international business affairs core of its business activities. Thus, the aim of this study is to review the concept of BGF theoretically and relate the issue to foreign trade affairs resting on significant sources related to the Turkish case mainly focusing on trade statistics as to review the potential development of BGFs in Turkey.

  17. A study on laws related to women's welfare.

    Science.gov (United States)

    Kim, E

    1991-01-01

    Since 1980, the domestic policy of every Korean government has focused on the construction of a welfare society, yet real change remains elusive, leaving women particularly neglected. This study examines social security legislation, especially the laws that define the status and welfare of women with the goal of advancing women's welfare and eliminating sexual discrimination against them. Welfare laws and literature were collected and examined from Korea and aboard, and facilities were visited. This paper reviews: 1) the theoretical background of women's welfare including the feminist critique and strategies for the welfare state and social welfare, and the significance and necessity of women's welfare; 2) women's welfare: international treaties and trends, including the World Declaration of Human Rights, international agreements on human rights, the International Labor Organization Treaty, the UN Convention on the Elimination of Sexual Discrimination Against Women, and the women's development strategies toward the year 2000; 3) the analysis of the laws and regulations related to women's welfare, including the systematic organization of women's welfare law (judicial, and systematic organization by applicable clients), the constitutional basis of the women's welfare related legislation and legal principles, the main feature and problems of the women's welfare related legislation, e.g. the Social Security Act: the National Pensions Act, Medical Insurance Act, the Livelihood Protection Act, Mother-child Welfare Act, Child Welfare Act, the Anti-prostitution Act, and the Gender Equal Employment Act, and 4) the direction of revision of the women's welfare related legislation including the revision and legislation of women's welfare related laws, restructuring of the delivery system, and the formation of proper environment conducive to the realization of women's welfare.

  18. A matrix model for valuing anesthesia service with the resource-based relative value system.

    Science.gov (United States)

    Sinclair, David R; Lubarsky, David A; Vigoda, Michael M; Birnbach, David J; Harris, Eric A; Behrens, Vicente; Bazan, Richard E; Williams, Steve M; Arheart, Kristopher; Candiotti, Keith A

    2014-01-01

    The purpose of this study was to propose a new crosswalk using the resource-based relative value system (RBRVS) that preserves the time unit component of the anesthesia service and disaggregates anesthesia billing into component parts (preoperative evaluation, intraoperative management, and postoperative evaluation). The study was designed as an observational chart and billing data review of current and proposed payments, in the setting of a preoperative holing area, intraoperative suite, and post anesthesia care unit. In total, 1,195 charts of American Society of Anesthesiology (ASA) physical status 1 through 5 patients were reviewed. No direct patient interventions were undertaken. Spearman correlations between the proposed RBRVS billing matrix payments and the current ASA relative value guide methodology payments were strong (r=0.94-0.96, Pbilling matrix yielded payments that were 3.0%±1.34% less than would have been expected from commercial insurers, using standard rates for commercial ASA relative value units and RBRVS relative value units. Compared with current Medicare reimbursement under the ASA relative value guide, reimbursement would almost double when converting to an RBRVS billing model. The greatest increases in Medicare reimbursement between the current system and proposed billing model occurred as anesthetic management complexity increased. The new crosswalk correlates with existing evaluation and management and intensive care medicine codes in an essentially revenue neutral manner when applied to the market-based rates of commercial insurers. The new system more highly values delivery of care to more complex patients undergoing more complex surgery and better represents the true value of anesthetic case management.

  19. A matrix model for valuing anesthesia service with the resource-based relative value system

    Science.gov (United States)

    Sinclair, David R; Lubarsky, David A; Vigoda, Michael M; Birnbach, David J; Harris, Eric A; Behrens, Vicente; Bazan, Richard E; Williams, Steve M; Arheart, Kristopher; Candiotti, Keith A

    2014-01-01

    Background The purpose of this study was to propose a new crosswalk using the resource-based relative value system (RBRVS) that preserves the time unit component of the anesthesia service and disaggregates anesthesia billing into component parts (preoperative evaluation, intraoperative management, and postoperative evaluation). The study was designed as an observational chart and billing data review of current and proposed payments, in the setting of a preoperative holing area, intraoperative suite, and post anesthesia care unit. In total, 1,195 charts of American Society of Anesthesiology (ASA) physical status 1 through 5 patients were reviewed. No direct patient interventions were undertaken. Results Spearman correlations between the proposed RBRVS billing matrix payments and the current ASA relative value guide methodology payments were strong (r=0.94–0.96, P<0.001 for training, test, and overall). The proposed RBRVS-based billing matrix yielded payments that were 3.0%±1.34% less than would have been expected from commercial insurers, using standard rates for commercial ASA relative value units and RBRVS relative value units. Compared with current Medicare reimbursement under the ASA relative value guide, reimbursement would almost double when converting to an RBRVS billing model. The greatest increases in Medicare reimbursement between the current system and proposed billing model occurred as anesthetic management complexity increased. Conclusion The new crosswalk correlates with existing evaluation and management and intensive care medicine codes in an essentially revenue neutral manner when applied to the market-based rates of commercial insurers. The new system more highly values delivery of care to more complex patients undergoing more complex surgery and better represents the true value of anesthetic case management. PMID:25336964

  20. Computational wing design studies relating to natural laminar flow

    Science.gov (United States)

    Waggoner, Edgar G.

    1986-01-01

    Two research studies are described which directly relate to the application of natural laminar flow (NLF) technology to transonic transport-type wing planforms. Each involved using state-of-the-art computational methods to design three-dimensional wing contours which generate significant runs of favorable pressure gradients. The first study supported the Variable Sweep Transition Flight Experiment and involves design of a full-span glove which extends from the leading edge to the spoiler hinge line on the upper surface of an F-14 outer wing panel. A wing was designed computationally for a corporate transport aircraft in the second study. The resulting wing design generated favorable pressure gradients from the leading edge aft to the mid-chord on both upper and lower surfaces at the cruise design point. Detailed descriptions of the computational design approach are presented along with the various constraints imposed on each of the designs.